WEBVTT 00:00:00.000 --> 00:00:06.280 and organic produce, natural groceries, nutritional supplements and body care products. 00:00:06.280 --> 00:00:12.480 Chautauqua Natural Foods is open Monday through Saturday 9 to 7, Sunday 10 to 5, just off the town square in Garberville. 00:00:12.480 --> 00:00:17.620 More information online, facebook.com/chautauquanaturals. 00:00:17.620 --> 00:00:20.560 Alright, Ask Your Herb Doctor coming up, stay tuned. 00:00:20.560 --> 00:00:21.360 My name's Andrew Murray. 00:00:21.360 --> 00:00:22.960 My name's Sarah Johannison Murray. 00:00:22.960 --> 00:00:28.460 Now for those of you who perhaps have never listened to the shows which run every third Friday of the month from 7 to 8 p.m., 00:00:28.460 --> 00:00:33.200 we're both licensed medical herbalists who trained in England and graduated there with a degree in herbal medicine. 00:00:33.200 --> 00:00:39.640 We run a clinic in Garberville where we consult with clients about a wide range of conditions and recommend herbal medicine and dietary advice. 00:00:39.640 --> 00:00:43.480 So you're listening to Ask Your Herb Doctor on KMED Garberville 91.1 FM. 00:00:43.480 --> 00:00:52.920 And from 7.30 until the end of the show at 8 o'clock, you're invited to call in with any questions related or unrelated to this month's subject of the continuing research on urea. 00:00:52.920 --> 00:01:04.260 The number if you live in the area is 923 3911, or if you live outside the area, there's a toll-free number which is 1-800-KMUD-RAD, which is 1-800-568-3723. 00:01:04.260 --> 00:01:11.200 And we can also be reached toll-free on 1-888-WBM-HERB for consultations or further information Monday through Friday. 00:01:11.200 --> 00:01:17.340 Okay, so once again, we're very pleased to have Dr. Raymond Peat joining us on the show to share in his latest research. 00:01:17.340 --> 00:01:18.480 Dr. Peat, are you there? 00:01:18.480 --> 00:01:18.980 Yes. 00:01:18.980 --> 00:01:20.780 Okay, thanks so much for joining us again. 00:01:20.780 --> 00:01:30.320 As always, just like to start the show by giving you the opportunity here to let people know your academic and scientific background, what you do and who you are. 00:01:30.320 --> 00:01:42.200 I got my PhD in biology, specializing in physiology and biochemistry, especially reproductive physiology at University of Oregon 1972. 00:01:42.200 --> 00:01:56.820 And before that, I had been interested in language, philosophy, and psychology and planned to study brain biology, but I found that the reproductive physiology seemed more scientific and more interesting. 00:01:56.820 --> 00:02:02.060 So I specialized in that but continued to be interested in the rest of the organism. 00:02:02.060 --> 00:02:13.400 So the first thing I did after graduating was to write a book on the brain, reviewing Russian science, 19th century through the 20th century on brain biology. 00:02:13.400 --> 00:02:24.880 And so I've continued interest in how the basic energy physiology relates to things such as reproduction, aging, and brain functions. 00:02:24.880 --> 00:02:47.380 All right, well, I know that your most recent newsletter, you were continuing your discourse and your thoughts on urea and its use in pathology and how you see the function of urea as benefiting people in light of perhaps it being dismissed, if you like, by mainstream medical science. 00:02:47.380 --> 00:02:59.180 I know that you mentioned Danopoulos, the Greek physician who's been successfully using urea as a therapy, injecting it into tumors and its use in cancer. 00:02:59.180 --> 00:03:13.500 But this newsletter that you've most recently written more explores some other physiological effects of urea that perhaps people might not have been aware of, or if in fact the research has been done some time ago, it may now be buried and forgotten. 00:03:13.500 --> 00:03:18.460 So just wanted to pick up on quite a few of the things that you mentioned in your newsletter. 00:03:18.460 --> 00:03:18.820 Go ahead. 00:03:18.820 --> 00:03:21.660 So, Daphne, can you tell us what urea is? 00:03:21.660 --> 00:03:25.300 Its name chemically is carbamide. 00:03:25.300 --> 00:03:29.660 It's just a combination of ammonia with carbon dioxide. 00:03:29.660 --> 00:03:33.740 And so it's the body's way of detoxifying ammonia. 00:03:33.740 --> 00:03:40.180 And it requires oxidative production of carbon dioxide to combine with the ammonia to get rid of it. 00:03:40.180 --> 00:03:47.300 And so it regulates cell pH, which regulates water metabolism and everything else in cell function. 00:03:47.300 --> 00:03:49.340 So it's something that our bodies produce. 00:03:49.340 --> 00:03:49.660 Yeah. 00:03:49.660 --> 00:03:49.940 All right. 00:03:49.940 --> 00:04:00.260 So given that we now understand that excess water in the cell is a central feature of the major degenerative diseases that you outline, things like heart failure, dementia and cancer. 00:04:00.260 --> 00:04:12.220 How do you explain how this happens and what is the best strategy to prevent this if water accumulation in the cell is implied in such an inflammatory situation as these things that we've mentioned? 00:04:12.220 --> 00:04:23.100 One of the dimensions of thinking about water in cells is that it comes up against some of the basic dogmas of what life is and how cells work and so on. 00:04:23.100 --> 00:04:32.180 And I think the reason that adenopolis amazing results in curing cancer with simply injecting or giving intravenous urea, 00:04:32.180 --> 00:04:43.420 I think the reason it's been ignored and dismissed is that it involves some ideas that don't fit with these mechanical dogmas of 20th century biology, 00:04:43.420 --> 00:04:58.900 such as the membrane theory, the idea that there are pumps in the cell surface membranes that regulate the amount of water and minerals in cells by somehow grabbing the molecules and pushing them in or out of the cell. 00:04:58.900 --> 00:05:05.700 It's really a silly, impossible concept, but it's what everything officially is based on. 00:05:05.700 --> 00:05:18.620 So when you actually look at the facts of what's happening with water, if you think in terms of things such as what happens when gelatin gets wet and swells up, 00:05:18.620 --> 00:05:27.460 and if you put acid or alkali on what happens to its relation to water and so on, acid makes it shrink, alkali makes it swell up. 00:05:27.460 --> 00:05:35.420 And simple physical ideas like that are very useful for thinking about what happens in all of the diseases. 00:05:35.420 --> 00:05:39.340 Okay, so acid makes it shrink and alkaline situations make it swell. 00:05:39.340 --> 00:05:56.020 Yeah, and swelling has an anabolic effect and turns on cell division and uncontrollable cell division and produce everything from cancer to various skin diseases of dandruff, for example, 00:05:56.020 --> 00:06:16.020 psoriasis, overgrowth of fibrous tissue, the control of cell growth is very deeply controlled by water and pH and the membrane pump people blame everything in life on this magical pump that regulates the water and the pH. 00:06:16.020 --> 00:06:34.020 If you just think about the basic metabolic processes in which you turn sugar or fat or protein into energy and carbon dioxide, this constant streaming of substance, carbon dioxide is an acid and you're making it inside cells. 00:06:34.020 --> 00:06:47.020 And so when you're alive, you're making cells acidic and as it leaves, it takes minerals out of the cell with it in the form of carbonic acid and the alkaline minerals associated with it. 00:06:47.020 --> 00:06:50.020 This is the better state than the alkaline state, though, right? 00:06:50.020 --> 00:07:12.020 Yeah, the alkaline acidic state produced by carbon dioxide causes a shift in the whole balance electrons in the protein, fat, nucleic acid system and that shift of electrons accounts for the preference of the cell for potassium normally over sodium. 00:07:12.020 --> 00:07:20.020 If the cell is disturbed, then it shifts and loses potassium and takes up calcium and sodium. 00:07:20.020 --> 00:07:25.020 This is what Gilbert Ling has devoted his life to for the last 60 some years. 00:07:25.020 --> 00:07:45.020 Sorry, I just wanted to say that this, I guess, for people that are listening, I think a lot of people in the lay people associate this kind of, what we're talking about acid versus alkali, they're always thinking about an acid situation is more cancer promoting and to be alkaline is a better situation in terms of health benefits. 00:07:45.020 --> 00:07:51.020 And that's true when you apply it to the blood and the fluid outside of cell. 00:07:51.020 --> 00:08:08.020 Right. But the reason the fluid outside of cells is alkaline is that the protons, the electrons are being retracted into an acidic state inside the cell and that shift of the balance and makes it alkaline outside. 00:08:08.020 --> 00:08:20.020 So what you're saying is when the cell inside and then when the inside of the cell becomes alkaline, that's when it becomes swollen and boggy and that's what can contribute to heart disease, cancer, psoriasis, all these degenerative diseases we've mentioned. 00:08:20.020 --> 00:08:26.020 And that goes with a shift towards acidity in the blood and the outside fluid. 00:08:26.020 --> 00:08:29.020 So that's where people are thinking about. 00:08:29.020 --> 00:08:32.020 You don't want to be acidic metabolically. 00:08:32.020 --> 00:08:48.020 That refers to the fluids outside of cells and it's only since the nuclear magnetic resonance apparatuses have been used the last 40 years, mostly, that people have started to recognize that inside cells should be slightly acidic. 00:08:48.020 --> 00:08:55.020 So how do we make the inside of ourselves more acidic and keep the outside of ourselves extra cellular and the blood alkaline? 00:08:55.020 --> 00:09:02.020 Keeping the energy flowing, producing carbon dioxide constantly by consuming oxygen. 00:09:02.020 --> 00:09:05.020 So we need our cells to be consuming oxygen properly. 00:09:05.020 --> 00:09:12.020 Yeah. And just suffocating, just turning off the oxygen supply so you stop making any supply of carbon dioxide. 00:09:12.020 --> 00:09:26.020 The metabolism shifts over to making lactic acid and the lactic acid takes acid out of the cell as it's leaving and acidifies the environment but leaves the cell more alkaline. 00:09:26.020 --> 00:09:34.020 Right. And that's a negative acidic situation that most people commonly refer to when they talk about acid versus alkaline blood. 00:09:34.020 --> 00:09:38.020 Yeah. It's a local inflammatory situation. 00:09:38.020 --> 00:09:44.020 Anytime a tissue is injured, it tends to produce excess lactic acid and become inflamed and inefficient. 00:09:44.020 --> 00:09:48.020 So how does urea help our cells use oxygen better? 00:09:48.020 --> 00:09:49.020 The... 00:09:49.020 --> 00:09:51.020 Or to keep the cell more acidic? 00:09:51.020 --> 00:10:05.020 The cell holds its structure by the way proteins are folded, which requires an interaction with the... everything in the cell has to participate in that slightly acidic state. 00:10:05.020 --> 00:10:20.020 Making carbon dioxide, keeping the ATP level at a high energy state, keeping the water participating in the way proteins are folded so that there's a lot of internal surface area exposed in the cell. 00:10:20.020 --> 00:10:30.020 Now the surface of a glass of water has a sort of rubbery film on the top that you can float a piece of steel or touch on the surface tension. 00:10:30.020 --> 00:10:43.020 Inside the cell when the proteins are energized, the ATP is holding them in this state exposing their surface, keeping the cell's water in that energized tough state that helps to hold the cell together. 00:10:43.020 --> 00:11:02.020 When de-energized, the structure collapses in various ways. For example, spherical proteins that were exposing all of their surface polymerize into dock-like proteins that have less surface exposure and the water becomes more like plain bulk water under the tough surface. 00:11:02.020 --> 00:11:12.020 This water then behaves very differently and that's the kind of water that is involved in cell swelling, growth, uncontrolled cell division and so on. 00:11:12.020 --> 00:11:24.020 It's also the pH inside the cell also regulates the protein's folding ability to a large degree that proteins don't conformationally fold properly in the wrong pH. 00:11:24.020 --> 00:11:38.020 Yeah, and it's in the case of any protein jelly, even some synthetic plastics, the alkalinity has the same effect making the jelly swell up and watery and soft. 00:11:38.020 --> 00:11:44.020 So again, another reason why the alkaline internal environment would not be helpful. 00:11:44.020 --> 00:11:46.020 Inside the cell. 00:11:46.020 --> 00:11:47.020 Inside the cell, yeah, yeah. 00:11:47.020 --> 00:12:01.020 Urea happens to be a strange kind of solvent that is pretty much equally at home inside and outside the cell, but it's slightly more at home in a healthy stable cell. 00:12:01.020 --> 00:12:12.020 So that just by solubility, if you immerse cells in a solution with a certain amount of urea, the urea is going to come to rest at a higher concentration in cells. 00:12:12.020 --> 00:12:19.020 No pumping is involved, it's simply that it's soluble in the cell at a slightly higher degree than in plain water. 00:12:19.020 --> 00:12:27.020 And inside the cell participates with the relaxed or energized state of the cell in which surfaces is exposed. 00:12:27.020 --> 00:12:35.020 So the urea helps proteins to expose the energized surface that keeps cells in the functioning high energy state. 00:12:35.020 --> 00:12:43.020 And that's how Denopolis helped with cancer was by injecting the urea into the cells and that helped them maintain their shape and function to a better degree? 00:12:43.020 --> 00:12:52.020 And to keep it towards the slightly acidic metabolizing state in which it doesn't tend to proliferate. 00:12:52.020 --> 00:12:55.020 A relatively slightly dehydrated effect. 00:12:55.020 --> 00:13:06.020 So it's like you have now a new solvent solute substance when it has the right amount of urea mixed in with the proteins and fat and water. 00:13:06.020 --> 00:13:18.020 It creates a new state of matter that has its own solubility properties for other things, including the preference for potassium over sodium and for magnesium over calcium and so on. 00:13:18.020 --> 00:13:22.020 Right. So it's helping the mineral balance of the cell be more balanced. 00:13:22.020 --> 00:13:28.020 Now, I think you also stated that urea itself is not an osmolite and it does not affect pH. Is that right? 00:13:28.020 --> 00:13:32.020 Yeah, that's been known for over 100 years. 00:13:32.020 --> 00:13:49.020 People simply use the semi-permeable membrane setup found that doesn't behave like sodium or potassium or other things that are known to be osmolites and to pull water across a semi-permeable membrane and so on. 00:13:49.020 --> 00:14:03.020 In 1914, I think it was the first one, but around the First World War, someone was demonstrating that you could make it five or six times more concentrated than it should be osmotically. 00:14:03.020 --> 00:14:07.020 And it would be in balance and not cause cells to lose water. 00:14:07.020 --> 00:14:16.020 Hold the cell in the proper state where if you add five or six times the concentration of sugar or salt, you would dry up. 00:14:16.020 --> 00:14:17.020 You'd be in trouble. 00:14:17.020 --> 00:14:20.020 When you put salt on the slug, it drinks it. 00:14:20.020 --> 00:14:21.020 Takes all the water out of it. 00:14:21.020 --> 00:14:25.020 Presumably, a slug wouldn't find concentrated urea. 00:14:25.020 --> 00:14:36.020 Interesting. And I think you've also mentioned that that concentration, five to six times, is nothing as much as, say, a hundred times, which is still compatible with life. 00:14:36.020 --> 00:14:40.020 It has a very, very low toxicity. It's not at all toxic, is it? 00:14:40.020 --> 00:14:47.020 No. And sea organisms, sharks, for example, have a very, very high level of urea imbalance. 00:14:47.020 --> 00:14:56.020 And experiments have shown that even more than a hundred times what we normally have doesn't cause any damage that can be seen in cells. 00:14:56.020 --> 00:15:11.020 And therapeutically, Danopoulos and others have found that maybe a hundred times our normal urea level in the serum is actually therapeutic for certain things, cancer and brain function, for example. 00:15:11.020 --> 00:15:23.020 Because I think there's quite a lot of references to urea from a "scientific community" that are not really interested in it or just trying to play it down as being irrelevant. 00:15:23.020 --> 00:15:31.020 And they have urea analogs, I think, which are far more problematic that they would want to suggest or not even mention urea. 00:15:31.020 --> 00:15:37.020 Sickle cell anemia, for example, was being treated successfully with urea. 00:15:37.020 --> 00:15:45.020 And normal cells under stress tend to be hardened the way sickle cells become stiff and won't go through capillaries. 00:15:45.020 --> 00:15:55.020 Just during heart surgery, the stress causes ordinary round blood cells to become stiffened and malfunction, tending to kill the patient. 00:15:55.020 --> 00:16:00.020 And with a supplement of urea, that hardening of the red cells by stress is prevented. 00:16:00.020 --> 00:16:05.020 And it was therapeutic for the sickle cell patients. 00:16:05.020 --> 00:16:22.020 But because of the myth of urea being an osmolite, someone used plain urea at a certain concentration without the normal sodium and other minerals in the solution and found that it broke, immediately caused red blood cells to break down. 00:16:22.020 --> 00:16:24.020 So they said that can't be good. 00:16:24.020 --> 00:16:31.020 They stopped using it and shifted over to very toxic carcinogenic hydroxyurea, which is still in use. 00:16:31.020 --> 00:16:35.020 But you do know doctors that use this current day, right? 00:16:35.020 --> 00:16:39.020 There are publications currently recommending us to use hydroxyurea. 00:16:39.020 --> 00:16:41.020 Did you mean using real urea? 00:16:41.020 --> 00:16:44.020 Yeah, I was meaning the real urea. 00:16:44.020 --> 00:16:50.020 A few people are using it, for example, to prevent killing patients in heart surgery. 00:16:50.020 --> 00:16:53.020 But it definitely isn't a well-recognized treatment. 00:16:53.020 --> 00:17:02.020 Did you say, did I understand you correctly when you said that urea in the absence of the other electrolytes would have a negative effect? 00:17:02.020 --> 00:17:07.020 Yeah, it acts like distilled water as far as the osmotic property goes. 00:17:07.020 --> 00:17:13.020 So it has to be osmotically balanced with the regular concentration of solutes that you'd normally find in blood. 00:17:13.020 --> 00:17:19.020 It would take about six times as much urea as normal to not break down the red cells. 00:17:19.020 --> 00:17:28.020 Interesting. So if you, whatever they, I'm not too sure what it is, but for example, just for people that are listening to understand the concept that I'm trying to describe to you and that you're describing to me, 00:17:28.020 --> 00:17:34.020 is that if you have, for example, a one millimolar concentration of urea in your blood normally, 00:17:34.020 --> 00:17:43.020 then if you were to inject a five or six millimolar concentration of urea into the capillary or into the artery or whatever, it wouldn't have a negative effect. 00:17:43.020 --> 00:17:44.020 It would be acceptable. 00:17:44.020 --> 00:17:49.020 But if it was injected as a one millimolar solution, which you'd find naturally in the blood, it would have a problem. 00:17:49.020 --> 00:17:57.020 You'd have a problem with that. Yeah. Assuming the other things like sodium and calcium and potassium aren't compensating for the difference in urea. 00:17:57.020 --> 00:17:59.020 So what about taking it orally? 00:17:59.020 --> 00:18:04.020 That's been done also for over 100 years of treating heart failure. 00:18:04.020 --> 00:18:13.020 And one person reported on, I think he said he had had heart failure patients doing well on oral urea for as long as nine years. 00:18:13.020 --> 00:18:16.020 And this is because it's a diuretic and it's. 00:18:16.020 --> 00:18:26.020 Yeah, that was the argument that they were using it because it did relieve the swollen legs and such that occur in heart failure. 00:18:26.020 --> 00:18:34.020 But I think since you also see it bringing people back from brain damage and traumatic head injury and strokes and such, 00:18:34.020 --> 00:18:42.020 I think has much deeper therapeutic effects, stabilizing cells in many ways, reducing the swelling by causing diuresis. 00:18:42.020 --> 00:18:47.020 OK, well, you're listening to AskUrEUp, Dr. KMED 91.1 FM Garbovill. 00:18:47.020 --> 00:18:54.020 This month, Dr. Peat is being questioned about his latest newsletter on urea. 00:18:54.020 --> 00:19:01.020 I know we've mentioned urea and Greek physician Dr. Danopoulos several months back in his treatment of cancer. 00:19:01.020 --> 00:19:10.020 But this month, we're going to be talking more about the other beneficial aspects of urea and certain other inflammatory conditions, 00:19:10.020 --> 00:19:12.020 dementia, cancer, etc. 00:19:12.020 --> 00:19:16.020 We'll be bringing out some of the reasons how urea could actually be very helpful for this. 00:19:16.020 --> 00:19:20.020 The number, if you live in the area, is 923-2513. 00:19:20.020 --> 00:19:23.020 923, sorry, beg your pardon, 923-3911. 00:19:23.020 --> 00:19:26.020 Or there is a toll free number, which is 1-800-KMED-RAD. 00:19:26.020 --> 00:19:30.020 So from 730 till the end of the show, people are invited to call in with any questions. 00:19:30.020 --> 00:19:34.020 It would be good if people could keep to the subject matter. 00:19:34.020 --> 00:19:39.020 OK, so anyway, the other question I wanted to ask you about the diuretic activity of urea, 00:19:39.020 --> 00:19:46.020 and you've mentioned it being useful in congestive heart failure and other edema type water swelling situations 00:19:46.020 --> 00:19:48.020 because of its ability to mobilize water. 00:19:48.020 --> 00:19:55.020 Do you have any comparisons, if you like, for traditional diuretics? 00:19:55.020 --> 00:19:58.020 I know that there used to be non-potassium sparing, 00:19:58.020 --> 00:20:02.020 and then they brought out these kind of loop diuretics that were potassium sparing. 00:20:02.020 --> 00:20:06.020 Well, I mean, the common furosemide that's still used is not potassium sparing. 00:20:06.020 --> 00:20:08.020 You have to take a potassium supplement with that. 00:20:08.020 --> 00:20:18.020 How do you--are you able to answer that, whether you have any opinion about diuretics and use versus something like urea? 00:20:18.020 --> 00:20:22.020 Yeah, I have opinions, but I finished thinking about the subject. 00:20:22.020 --> 00:20:25.020 You remember, mercury was a traditional diuretic, 00:20:25.020 --> 00:20:31.020 and it apparently worked just by sort of killing the tubes of the kidney 00:20:31.020 --> 00:20:33.020 and letting the water kind of fall out of the body. 00:20:33.020 --> 00:20:35.020 Not to be recommended. 00:20:35.020 --> 00:20:39.020 So unlike, you know, radiation was useful for treating psoriasis, 00:20:39.020 --> 00:20:43.020 x-rays were useful for treating psoriasis and arthritis, right? 00:20:43.020 --> 00:20:51.020 Yeah, and I think some of the chemical diuretics are about as well-founded as mercury diuretics. 00:20:51.020 --> 00:20:58.020 The chemicals that made the kidneys give up more water don't necessarily really improve the person's health. 00:20:58.020 --> 00:21:00.020 The cells could be still holding onto the water and not-- 00:21:00.020 --> 00:21:08.020 Yeah, and besides stress, for example, in heart surgery, it involves water retention, 00:21:08.020 --> 00:21:14.020 failure of the kidney function leading to things like hardening of the red blood cells 00:21:14.020 --> 00:21:16.020 and stiffening of the capillaries and so on. 00:21:16.020 --> 00:21:23.020 Any stress involves a series of reactions, all of which relate to the way cells handle water. 00:21:23.020 --> 00:21:28.020 Nitric oxide is a universally produced thing by injury and stress, 00:21:28.020 --> 00:21:32.020 and it causes de-energizing and swelling of cells. 00:21:32.020 --> 00:21:38.020 And estrogen is a physiological producer of swelling, imitating a stress reaction 00:21:38.020 --> 00:21:40.020 and being produced by stress. 00:21:40.020 --> 00:21:45.020 And one of the brain or pituitary hormones, antidiuretic hormone, 00:21:45.020 --> 00:21:50.020 is another stress-induced producer of water retention and edema. 00:21:50.020 --> 00:21:55.020 And old people as well as traumatized people who are hospitalized 00:21:55.020 --> 00:22:00.020 fairly often develop a state of water retention with sodium loss. 00:22:00.020 --> 00:22:06.020 They call it hyponatremia or the syndrome of inappropriate antidiuretic hormone. 00:22:06.020 --> 00:22:10.020 Estrogen happens to produce the same effect, 00:22:10.020 --> 00:22:16.020 and so they say estrogen activates receptors of the antidiuretic hormone. 00:22:16.020 --> 00:22:20.020 When you can't find the actual hormone at the same conditions, 00:22:20.020 --> 00:22:23.020 they say it's because the receptors are acting independent. 00:22:23.020 --> 00:22:30.020 Nitric oxide, estrogen, and antidiuretic hormone produce the state of getting waterlogged 00:22:30.020 --> 00:22:35.020 while losing sodium into the urine and producing fairly concentrated urine 00:22:35.020 --> 00:22:40.020 but keeping overhydrated cells and blood supply. 00:22:40.020 --> 00:22:46.020 And the normal basic thing that regulates the ability to release water through the kidneys 00:22:46.020 --> 00:22:52.020 while retaining sodium is the particular energized electronic state of the cells 00:22:52.020 --> 00:22:58.020 governing the way the tube of the kidney electrically relates to its surroundings. 00:22:58.020 --> 00:23:05.020 The production of carbon dioxide and carbonic acid, the carbonic anhydrase enzyme, 00:23:05.020 --> 00:23:09.020 is one of the targets of some of the diuretics such as acetazolamide 00:23:09.020 --> 00:23:14.020 so that the body retains more carbon dioxide and thus doesn't lose so much sodium. 00:23:14.020 --> 00:23:21.020 And the normal regulator of carbon dioxide and so of sodium water balance 00:23:21.020 --> 00:23:27.020 is the thyroid hormone, and hypothyroid people always tend towards this syndrome 00:23:27.020 --> 00:23:32.020 of inappropriate antidiuretic hormone secretion or the appearance, 00:23:32.020 --> 00:23:37.020 simply hyponatremia, of being waterlogged, having enough water, enough sodium. 00:23:37.020 --> 00:23:42.020 So the sodium itself, sodium chloride or sodium bicarbonate, 00:23:42.020 --> 00:23:45.020 can cure a lot of these stress conditions. 00:23:45.020 --> 00:23:51.020 And the same waterlogging could be borne out in things like a boggy intestine or a swollen intestine 00:23:51.020 --> 00:23:57.020 that fails to move food along properly and contributes to endotoxin reabsorption 00:23:57.020 --> 00:23:59.020 because of the inefficient movement? 00:23:59.020 --> 00:24:04.020 Yeah, the intestine is especially exposed to things such as endotoxin, 00:24:04.020 --> 00:24:11.020 which release nitric oxide, which has this de-energizing cell swelling effect, waterlogging effect. 00:24:11.020 --> 00:24:14.020 And the bicarbonate of soda you mentioned just before I interrupted there 00:24:14.020 --> 00:24:18.020 would be another good way of liberating CO2, 00:24:18.020 --> 00:24:22.020 and taken internally would have a local topical activity too? 00:24:22.020 --> 00:24:28.020 Yeah, and surprisingly, even sodium chloride has a diuretic effect, most people. 00:24:28.020 --> 00:24:35.020 When you use the baking soda, the kidneys are able to retain as much sodium as they want, 00:24:35.020 --> 00:24:39.020 but the bicarbonate can be changed back into carbon dioxide 00:24:39.020 --> 00:24:46.020 and it can actually help to acidify cells on the inside while maintaining the sodium on the outside. 00:24:46.020 --> 00:24:51.020 So that's something people can just swallow by a quarter teaspoon or half teaspoon mixed with water? 00:24:51.020 --> 00:24:57.020 Yeah, I know people who have taken a teaspoon two or three times a day with water many years. 00:24:57.020 --> 00:25:02.020 Athletes sometimes take a tablespoon with water before an endurance race. 00:25:02.020 --> 00:25:09.020 I think part of the effect on endurance is more basic than just preventing getting waterlogged. 00:25:09.020 --> 00:25:14.020 I think it's actually helping to prevent excess nitric oxide production. 00:25:14.020 --> 00:25:18.020 Am I not right in thinking that the endurance runners, marathon runners, 00:25:18.020 --> 00:25:27.020 some of these people collapsing from cardiac arrest are hyponatremic, so they suddenly get low sodium? 00:25:27.020 --> 00:25:33.020 Yeah, I think that's probably the most common reason for endurance runners collapsing and dying. 00:25:33.020 --> 00:25:39.020 Okay, well you're listening to Ask Your Ob-Doctor, KMED Galvapour 91.1 FM, and from now until 8 o'clock. 00:25:39.020 --> 00:25:44.020 You're invited to call in with any questions surrounding this month's continuing topic of urea 00:25:44.020 --> 00:25:49.020 and its treatment in such things as cardiac illnesses, dementia, cancer, 00:25:49.020 --> 00:25:52.020 and we'll get into a few others here later on. 00:25:52.020 --> 00:26:00.020 The number is, like I said, 93391 or 3911, or if you live outside the area, there's a 1800 number, which is 1800 KMED Rad. 00:26:00.020 --> 00:26:05.020 So going on to aging seems a little bit indistinct perhaps from this month's subject, 00:26:05.020 --> 00:26:13.020 but in terms of the concept of hydration and skin and the appearance of skin and the water content of cells, 00:26:13.020 --> 00:26:19.020 not necessarily being helpful but being more detrimental and in a lower energy state, 00:26:19.020 --> 00:26:28.020 I wanted you to just discuss the idea of young babies and newborns and young teenagers and young adults 00:26:28.020 --> 00:26:32.020 having a kind of a fairly plump, healthy skin that's fairly thick. 00:26:32.020 --> 00:26:39.020 I don't want to confuse that with the skin being boggy because that would seem to imply that there's too much water in the cells, 00:26:39.020 --> 00:26:44.020 but in terms of the aging and youth and the skin's appearance and the production of keratin, 00:26:44.020 --> 00:26:48.020 which is that kind of flaky layer, maybe more associated with older people, 00:26:48.020 --> 00:26:56.020 is there anything perhaps that can be done to improve the quality of the skin that would be related to water? 00:26:56.020 --> 00:27:00.020 The plumpness is largely the water content. 00:27:00.020 --> 00:27:06.020 Any cell, all the way from fertilized ovum all the way to a 100-year-old person, 00:27:06.020 --> 00:27:15.020 the cell water content decreases pretty steadily with aging until an old cell, which is still very functional. 00:27:15.020 --> 00:27:22.020 There's no disease evident. It's pretty dried up relative to the 92% water of fertilized ovum. 00:27:22.020 --> 00:27:31.020 It gets down to something like 65% water in old cells as a steady progression without any particular disease happening. 00:27:31.020 --> 00:27:40.020 As that happens, cell division is slowed so that in your skin, over time, you see fewer cells in the skin, 00:27:40.020 --> 00:27:46.020 meaning that it's thinner. There just isn't as much living skin there in old people. 00:27:46.020 --> 00:27:54.020 The column of growing cells in the surface layer, the squamous epithelium of skin and the mucous membranes, 00:27:54.020 --> 00:27:58.020 there's a column of eight or 10 growing cells in the young skin, 00:27:58.020 --> 00:28:04.020 and only maybe two or three cells that are still actively growing in old skin. 00:28:04.020 --> 00:28:10.020 That's partly just because they're slowing down, but they're also the piling up, 00:28:10.020 --> 00:28:16.020 collapsed, cornified or keratinized cells accumulate in the old skin. 00:28:16.020 --> 00:28:24.020 The maturing process comes on prematurely with aging or with some type of stress. 00:28:24.020 --> 00:28:32.020 For example, a vitamin A deficiency will cause premature keratinizing or hardening of the skin 00:28:32.020 --> 00:28:37.020 and will become thinner and tougher, lower water content. 00:28:37.020 --> 00:28:44.020 Estrogen does this normally cyclically in the mucous membranes, causing at first a faster growth 00:28:44.020 --> 00:28:51.020 because there's a greater water uptake under the influence of estrogen, rapid thickening and growing, 00:28:51.020 --> 00:28:56.020 but then an increased formation of keratin fibers and hardening surface. 00:28:56.020 --> 00:29:01.020 So some of the effects of estrogen are just like vitamin A deficiency, 00:29:01.020 --> 00:29:05.020 and you can offset some of the effects both of aging and estrogen 00:29:05.020 --> 00:29:10.020 by simply supplementing some vitamin A and vitamin E directly into the skin. 00:29:10.020 --> 00:29:15.020 And urea, old skin has much less urea in it than young skin, 00:29:15.020 --> 00:29:21.020 and that's probably both the cause and effect of the lower water content with aging. 00:29:21.020 --> 00:29:24.020 We do have another call, not another, we have the first call on the line, 00:29:24.020 --> 00:29:28.020 so let me hold you there Dr. Peat if you don't mind, and let's take this next call and see where we're going. 00:29:28.020 --> 00:29:30.020 Hi, caller, you're on there, and where are you from? 00:29:30.020 --> 00:29:31.020 I'm from White Thorn. 00:29:31.020 --> 00:29:32.020 Okay, hi. 00:29:32.020 --> 00:29:37.020 Hi, my dad is in the hospital right now with CHF and dementia, 00:29:37.020 --> 00:29:45.020 and also interactions between his medicine for the most of my for the diuretic and gabapentin 00:29:45.020 --> 00:29:49.020 and one for his heart too, but his lactic acid was normal, 00:29:49.020 --> 00:29:52.020 but the creatinine was not normal, 00:29:52.020 --> 00:30:00.020 and I'm wondering if the oral urea would be better for him to take and not take the fluorosamide. 00:30:00.020 --> 00:30:07.020 Dr. Peat, you can find articles about the use of urea in heart failure, 00:30:07.020 --> 00:30:10.020 comparing it to other diuretics on PubMed, for example. 00:30:10.020 --> 00:30:15.020 If you put in urea heart failure, you can find the articles on PubMed. 00:30:15.020 --> 00:30:16.020 Okay, thank you. 00:30:16.020 --> 00:30:19.020 Would that be something he could use orally? 00:30:19.020 --> 00:30:24.020 It's very tasteless, a little maybe on the salty side, 00:30:24.020 --> 00:30:30.020 so it's usually taken with orange juice or grapefruit juice just so you don't taste it, 00:30:30.020 --> 00:30:35.020 a small amount, anywhere from a fourth of a teaspoon to a glass, up to maybe a teaspoon per glass. 00:30:35.020 --> 00:30:36.020 Okay, good. 00:30:36.020 --> 00:30:41.020 Would it be okay to take that with his diuretic he has already prescribed? 00:30:41.020 --> 00:30:46.020 I don't think it interferes with diuretics, but it just makes them unnecessary. 00:30:46.020 --> 00:30:48.020 Okay, well, that's good to hear. 00:30:48.020 --> 00:30:50.020 I thank you for helping me. 00:30:50.020 --> 00:30:51.020 All right, thanks for your call. 00:30:51.020 --> 00:30:54.020 We've got two more callers on the air, so let's take the next caller. 00:30:54.020 --> 00:30:56.020 Caller, you're on the air, and where are you from? 00:30:56.020 --> 00:30:57.020 Yes, hello, Philipsville. 00:30:57.020 --> 00:30:58.020 Oh, hi. 00:30:58.020 --> 00:31:07.020 Yes, I would like to know what one should ingest to make the cells more acidic on the inside 00:31:07.020 --> 00:31:12.020 and the blood better, you know, more alkaline on the outside, like you're saying is good for you. 00:31:12.020 --> 00:31:13.020 Protein. 00:31:13.020 --> 00:31:16.020 You say that ingesting this urea is good. 00:31:16.020 --> 00:31:23.020 Getting adequate protein in your diet is probably the thing that most people could make the biggest difference with. 00:31:23.020 --> 00:31:25.020 Oh, that increases urea, you're saying, Dr. Peat? 00:31:25.020 --> 00:31:34.020 Yes, you can measure the increased output of urea in the urine in proportion to the amount of protein you're eating 00:31:34.020 --> 00:31:38.020 if your digestion is good and if your thyroid function is good. 00:31:38.020 --> 00:31:40.020 So eating red meat is good for that? 00:31:40.020 --> 00:31:43.020 It shouldn't be too high in phosphate. 00:31:43.020 --> 00:31:48.020 Meat is very high in phosphate, and so gelatin is good as a supplement. 00:31:48.020 --> 00:31:55.020 If you make soup with the collagenous joint tissue, for example. 00:31:55.020 --> 00:31:57.020 Like oxtail or shank. 00:31:57.020 --> 00:31:58.020 Oxtail, yes. 00:31:58.020 --> 00:32:02.020 Do you recommend then just eating a little bit of meat and not too much? 00:32:02.020 --> 00:32:09.020 Yeah, I think it's better to get a big part of your protein from other foods such as eggs, milk, and cheese. 00:32:09.020 --> 00:32:10.020 Eggs? 00:32:10.020 --> 00:32:14.020 And some high-quality vegetables like potatoes and mushrooms. 00:32:14.020 --> 00:32:17.020 Eggs, milk, and cheese, potatoes, mushrooms, those are some high-protein. 00:32:17.020 --> 00:32:18.020 Are eggs good? 00:32:18.020 --> 00:32:19.020 Yes. 00:32:19.020 --> 00:32:20.020 Eggs are very good. 00:32:20.020 --> 00:32:22.020 Okay, and you mentioned sodium chloride. 00:32:22.020 --> 00:32:23.020 That's salt. 00:32:23.020 --> 00:32:28.020 Is salt good for your heart or for your blood? 00:32:28.020 --> 00:32:32.020 I'm sorry, what were you talking about? 00:32:32.020 --> 00:32:33.020 Is putting salt in your food good? 00:32:33.020 --> 00:32:36.020 There are some articles on my website about salt. 00:32:36.020 --> 00:32:39.020 You can use the little search device on the website to find-- 00:32:39.020 --> 00:32:42.020 I don't have a computer. 00:32:42.020 --> 00:32:45.020 Yeah, salting your food to taste is the best way to tell. 00:32:45.020 --> 00:32:48.020 And that will keep your kidneys functioning better? 00:32:48.020 --> 00:32:51.020 Yeah, in people who are under stress. 00:32:51.020 --> 00:32:54.020 For example, women with toxemia of pregnancy. 00:32:54.020 --> 00:33:02.020 Well, what about just in general, just normal, you know, aging and wanting to keep as healthy as you can when you're getting older? 00:33:02.020 --> 00:33:12.020 Yeah, I've known many young women and a few old people who have been put on a low-sodium diet because of various problems. 00:33:12.020 --> 00:33:19.020 And using the studies on pregnant toxemia people, I suggested that they try the same thing. 00:33:19.020 --> 00:33:20.020 Now, what about potassium? 00:33:20.020 --> 00:33:22.020 What does that do for you? 00:33:22.020 --> 00:33:24.020 I know low potassium isn't good. 00:33:24.020 --> 00:33:32.020 Too much potassium can slow your heart rate, but the right amount, such as having lots of fruit and vegetables, 00:33:32.020 --> 00:33:37.020 potassium tends to protect against high blood pressure, relaxing blood vessels. 00:33:37.020 --> 00:33:41.020 So as you were saying, Dr. Peat, you were saying that using the studies they did on the pregnant women, 00:33:41.020 --> 00:33:44.020 you can apply the same principle to aging? 00:33:44.020 --> 00:33:53.020 I saw the same problems existing in women in their 20s and 30s and men in their 60s, 70s, and 80s, 00:33:53.020 --> 00:33:59.020 having a variety of inflammatory high blood pressure symptoms and such. 00:33:59.020 --> 00:34:04.020 I suggested that they salt their food to taste instead of a low-sodium diet. 00:34:04.020 --> 00:34:09.020 Yes, I know there's a lot of controversy about salt, and we've been taught a lot that salt is bad, 00:34:09.020 --> 00:34:13.020 it causes high blood pressure, it causes water retention, so you don't think that's true? 00:34:13.020 --> 00:34:18.020 Well, they've disproven that, and they only started saying you shouldn't eat salt when they wanted to sell their diuretics, 00:34:18.020 --> 00:34:21.020 so it's just been all one big scam. 00:34:21.020 --> 00:34:27.020 Okay, well, I've had one cardiologist tell me not to eat salt, although she didn't want to give me a diuretic, 00:34:27.020 --> 00:34:32.020 and the other one said, "Yes, eat salt because it'll keep up your blood volume, and that's probably good for you." 00:34:32.020 --> 00:34:37.020 Yeah, the blood volume, oxygen and nutrients to the kidneys, and keeps them working. 00:34:37.020 --> 00:34:39.020 So hydration is very important. 00:34:39.020 --> 00:34:45.020 But what about the first question I asked about the cells, to make sure that the inner cells are acidic enough? 00:34:45.020 --> 00:34:48.020 Well, that was the protein. That's why he suggested the protein, because that will keep the urea up. 00:34:48.020 --> 00:34:52.020 Okay, so eat protein, eat salt, but not too much meat. 00:34:52.020 --> 00:34:57.020 I know that there was a--gout is supposed to be caused by eating too much meat. 00:34:57.020 --> 00:34:59.020 I'm not sure what gout is. 00:34:59.020 --> 00:35:02.020 Well, doctors aren't too sure what it is either, but the essential thing, 00:35:02.020 --> 00:35:08.020 people can have a lot of uric acid crystals in their body without having any symptoms at all. 00:35:08.020 --> 00:35:18.020 It seems to be endotoxin from an inflamed intestine getting deposited on the crystals of uric acid, causing the symptoms. 00:35:18.020 --> 00:35:22.020 So we want to have urea, but not uric crystals? 00:35:22.020 --> 00:35:26.020 Yeah, urea is protective uric acid. 00:35:26.020 --> 00:35:31.020 Okay, so that's--by eating a proper amount of protein, the good thing to do for that, you're saying. 00:35:31.020 --> 00:35:33.020 Okay, all right, thank you very much. 00:35:33.020 --> 00:35:34.020 Thank you very much. 00:35:34.020 --> 00:35:38.020 Okay, we do have another caller on the line, so let's take this next caller. Caller, where are you from? 00:35:38.020 --> 00:35:39.020 Willow Creek. 00:35:39.020 --> 00:35:40.020 Hi, what's your question? 00:35:40.020 --> 00:35:47.020 Okay, I've been--I've had water retention problems ever since I was pregnant with my first child. 00:35:47.020 --> 00:35:48.020 Okay. 00:35:48.020 --> 00:35:52.020 And I do have an underactive thyroid, and they always tell me not to eat any salt. 00:35:52.020 --> 00:36:01.020 And then I went to a healer a few months ago, and he told me that I should use--oh, it's salt from France. 00:36:01.020 --> 00:36:02.020 I forget what it's called. 00:36:02.020 --> 00:36:08.020 But anyway, so I did, but I was still swelling up, and I'm on diuretic. 00:36:08.020 --> 00:36:10.020 How much thyroid are you using? 00:36:10.020 --> 00:36:11.020 How much what? 00:36:11.020 --> 00:36:14.020 How much thyroid. Did you say you were using thyroid? 00:36:14.020 --> 00:36:21.020 Oh, yeah, thyroid pills, yeah. I think, like, I don't know, 100 milligrams or something, 1 gram. 00:36:21.020 --> 00:36:22.020 Of synthroid or-- 00:36:22.020 --> 00:36:23.020 And you said that you were-- 00:36:23.020 --> 00:36:24.020 Levothroxine. 00:36:24.020 --> 00:36:27.020 You said that you had water retention since your first child. 00:36:27.020 --> 00:36:28.020 Yes. 00:36:28.020 --> 00:36:29.020 How many years since? 00:36:29.020 --> 00:36:32.020 Since pregnancy. That was 45 years ago. 00:36:32.020 --> 00:36:33.020 45 years ago. Dr. Peat? 00:36:33.020 --> 00:36:37.020 Yeah, so I've had it all these years, and my mom had it instead of my grandmother. 00:36:37.020 --> 00:36:46.020 For quite a while, it's been known that estrogen interferes with the conversion of levothyroxine into the active hormone, 00:36:46.020 --> 00:36:55.020 and that accounts for why women have about five times as much thyroid problems as men do because of the interference of estrogen with activating it. 00:36:55.020 --> 00:37:06.020 And so, illogically, doctors prescribe thyroxine to women without measuring the liver function of producing the active hormone T3. 00:37:06.020 --> 00:37:09.020 Yeah, I don't think I've ever had it for that. 00:37:09.020 --> 00:37:16.020 It sounds like you're not using the right kind of hormone, so the levothyroxine that you're on-- 00:37:16.020 --> 00:37:17.020 It's just T4. 00:37:17.020 --> 00:37:19.020 --is probably being blocked. 00:37:19.020 --> 00:37:23.020 The conversion of it to the active hormone is more than likely getting blocked because of high estrogen, 00:37:23.020 --> 00:37:28.020 so you'd be better off using a T3 supplement, which does not need you to perform a conversion. 00:37:28.020 --> 00:37:34.020 So you're probably still a low thyroid, even though you're taking thyroid hormone, because you're not converting it. 00:37:34.020 --> 00:37:39.020 Yeah, well, according to their tests, I'm normal now on the levothyroxine. 00:37:39.020 --> 00:37:42.020 Yeah, there's a lot of controversy about the thyroid test. 00:37:42.020 --> 00:37:46.020 The TSH that's used as a measurement is very poor science. 00:37:46.020 --> 00:37:51.020 And whilst the TSH may be in the range, you probably find it's on the higher end, 00:37:51.020 --> 00:37:55.020 and naturally your temperature and pulses would be much more indicative of your thyroid performance. 00:37:55.020 --> 00:37:58.020 Oh, what do you mean by temperature, high or low? 00:37:58.020 --> 00:38:01.020 Probably low temperature and falling temperatures. 00:38:01.020 --> 00:38:03.020 I tend to have a low temperature. 00:38:03.020 --> 00:38:07.020 And then obviously things like stubborn weight gain, lack of energy, insomnia. 00:38:07.020 --> 00:38:09.020 Very lack of energy. 00:38:09.020 --> 00:38:11.020 It's gotten worse this year. 00:38:11.020 --> 00:38:12.020 Yeah. 00:38:12.020 --> 00:38:13.020 Low pulse. 00:38:13.020 --> 00:38:14.020 It's really bad. 00:38:14.020 --> 00:38:17.020 And I went to the doctors for it, and they said they can't find any problem. 00:38:17.020 --> 00:38:23.020 Well, it's probably just that you're not turning the thyroid you're taking into an active form that your body can use. 00:38:23.020 --> 00:38:27.020 So that's probably the base problem, and that's very common to occur after pregnancy. 00:38:27.020 --> 00:38:31.020 So if I wanted to get that test, do I have to ask my doctor to do it for me? 00:38:31.020 --> 00:38:32.020 Do I have to request it? 00:38:32.020 --> 00:38:38.020 Yeah, you could, but like you said, you're probably falling within the reference range for supposedly normal, 00:38:38.020 --> 00:38:41.020 but actually your physiology and your symptoms are far from. 00:38:41.020 --> 00:38:45.020 So I'm not too sure how relevant getting another blood test would be. 00:38:45.020 --> 00:38:49.020 I think more relevantly would be if you were to take your temperature and pulses. 00:38:49.020 --> 00:38:53.020 It's a little bit outside the scope of the radio show because we do have other callers calling. 00:38:53.020 --> 00:38:58.020 But if you wanted to, you can always contact us outside of business hours, 00:38:58.020 --> 00:39:03.020 and I can discuss with you how you would take this, and you can see for yourself whether or not you're metabolizing. 00:39:03.020 --> 00:39:06.020 Okay, so I would go on the website then for that? 00:39:06.020 --> 00:39:08.020 No, you can call us Monday through Friday. 00:39:08.020 --> 00:39:10.020 I'll give a number out at the end of the show. 00:39:10.020 --> 00:39:11.020 Okay, thank you. 00:39:11.020 --> 00:39:12.020 Okay, you're welcome. 00:39:12.020 --> 00:39:15.020 Okay, we have another caller on the air, so let's take this next caller. 00:39:15.020 --> 00:39:16.020 Thank you for your call. 00:39:16.020 --> 00:39:17.020 Hi, you're on the air. Where are you from? 00:39:17.020 --> 00:39:18.020 Yes, hello? 00:39:18.020 --> 00:39:19.020 Yeah, you're on the air. Where are you from? 00:39:19.020 --> 00:39:27.020 Yes, hello. I'm from Bellevue, Idaho, and my question is, is drinking your own urine a good way to get urea? 00:39:27.020 --> 00:39:28.020 Dr. Peat. 00:39:28.020 --> 00:39:33.020 I know quite a few people who have done it and seem to be very healthy, 00:39:33.020 --> 00:39:37.020 and it's been practiced for about 3,000 or 4,000 years, 00:39:37.020 --> 00:39:45.020 but I don't know, I think most people would prefer to use the purified chemical rather than their own urine. 00:39:45.020 --> 00:39:53.020 There's a funny video of a man in India who is preparing products from cow urine. 00:39:53.020 --> 00:39:57.020 It's a very common folk remedy around the world. 00:39:57.020 --> 00:39:58.020 So there you go. 00:39:58.020 --> 00:40:04.020 If you don't fancy the idea of consuming your own urine, you can use urea as a purified form. 00:40:04.020 --> 00:40:07.020 Did you, okay, I'm not too sure if the call is still there. 00:40:07.020 --> 00:40:08.020 Anyway, that was the answer. 00:40:08.020 --> 00:40:09.020 Thank you for your question, caller. 00:40:09.020 --> 00:40:12.020 I don't know if you can hear us still, but I appreciate you calling in. 00:40:12.020 --> 00:40:16.020 So, yeah, it's six minutes to, if anybody wants to get a quick question in, 00:40:16.020 --> 00:40:23.020 either welcome, 923 3911 if you're in the area, or the 1-800 number is 1-800-KMUD-RAD. 00:40:23.020 --> 00:40:30.020 So, Dr. Peat, let's just quickly talk about psoriasis and urea and inflammatory bowel disease, 00:40:30.020 --> 00:40:34.020 given that there is a kind of parallel between psoriasis and inflammatory bowel disease 00:40:34.020 --> 00:40:42.020 in terms of the inflammation aspect of degenerative conditions and urea's use in both psoriasis 00:40:42.020 --> 00:40:45.020 and possibly with inflammatory bowel disorder. 00:40:45.020 --> 00:40:47.020 And eczema, it's used in eczema. 00:40:47.020 --> 00:40:53.020 And eczema, right, because the science shows that urea actually blocks, sorry, 00:40:53.020 --> 00:40:57.020 I was thinking about tumor necrosis factor, that was it, and curcuma. 00:40:57.020 --> 00:41:03.020 So, in turmeric, it blocks the active compound curcumin, blocks tumor necrosis factor, 00:41:03.020 --> 00:41:07.020 and that is implicated in a lot of inflammatory conditions of which skin disorders 00:41:07.020 --> 00:41:11.020 and inflammatory bowel disease could be exacerbated or even caused by. 00:41:11.020 --> 00:41:12.020 Do you have any-- 00:41:12.020 --> 00:41:18.020 Well, one thing to consider when you have both bowel and skin symptoms 00:41:18.020 --> 00:41:25.020 is that the bowel is actually causing or contributing to the skin problem 00:41:25.020 --> 00:41:31.020 and eliminating gluten, for example, sometimes clears up both the bowel and skin problem 00:41:31.020 --> 00:41:35.020 because some of the same enzymes are activated by inflammation 00:41:35.020 --> 00:41:41.020 that cause the premature hardening and flakiness of the skin in psoriasis. 00:41:41.020 --> 00:41:48.020 That same process is activated by gluten and other inflammation-producing agents in the intestine. 00:41:48.020 --> 00:41:57.020 The process of psoriasis is an accelerated cell division which is probably caused by the overhydration 00:41:57.020 --> 00:42:02.020 and possibly lack of the right balance of estrogen, progesterone, and thyroid 00:42:02.020 --> 00:42:07.020 and maybe a deficiency of vitamin A which is a restraining influence. 00:42:07.020 --> 00:42:08.020 Or vitamin D, right? 00:42:08.020 --> 00:42:13.020 Yes, both vitamin D and A can restrain the rate of multiplication. 00:42:13.020 --> 00:42:20.020 And besides having a very fast cell division in psoriasis, it divides quickly a few times 00:42:20.020 --> 00:42:26.020 and then prematurely ages and collapses into the flaky, horny, dry condition. 00:42:26.020 --> 00:42:32.020 And urea has been demonstrated to delay or prevent premature hardening process 00:42:32.020 --> 00:42:41.020 by governing the expression of the genes so that the denility-producing proteins aren't produced so early 00:42:41.020 --> 00:42:49.020 and keeping the cell in a vital state longer and delaying both the replication and the premature aging. 00:42:49.020 --> 00:42:53.020 So it sounds like urea can be injected or doctors are injecting it into cancer cells. 00:42:53.020 --> 00:42:59.020 It can be injected into the bloodstream, can be rubbed on topically for skin conditions, 00:42:59.020 --> 00:43:01.020 and it can be taken orally. 00:43:01.020 --> 00:43:05.020 Yes, there are creams available on the Internet at drugstores and so on 00:43:05.020 --> 00:43:09.020 containing anything from 5% to 40% urea. 00:43:09.020 --> 00:43:12.020 Forty percent is almost a concentrated solution, 00:43:12.020 --> 00:43:21.020 and it's very effective for treating several ichthyosis and psoriasis, various skin conditions. 00:43:21.020 --> 00:43:27.020 And some doctors and pharmacists might tell you that it's used to remove toenails 00:43:27.020 --> 00:43:31.020 or to remove dead tissue and so on, and so they all scare you 00:43:31.020 --> 00:43:37.020 and say that because you can remove calluses with it, it must be dangerous to good skin. 00:43:37.020 --> 00:43:41.020 But 40% solutions are very soothing and therapeutic. 00:43:41.020 --> 00:43:47.020 It is now widely used for treating the skin inflammation, breast cancer patients 00:43:47.020 --> 00:43:52.020 who have been exposed to so much x-ray, the skin has been damaged, 00:43:52.020 --> 00:43:57.020 and it prevents the inflammation and fibrosis produced by x-rays. 00:43:57.020 --> 00:44:02.020 And it's also the topical skin creams of urea are also very similar in action 00:44:02.020 --> 00:44:04.020 to how Comfrey works with the allantoin. 00:44:04.020 --> 00:44:09.020 We've got about a minute left, so I really need to hold it right there so we don't get too overextended. 00:44:09.020 --> 00:44:11.020 Dr. Peat, thanks so much for your time. 00:44:11.020 --> 00:44:15.020 I really appreciate you giving your time the way you do as freely as you do, 00:44:15.020 --> 00:44:18.020 and let me just tell people how they can find more out about you. 00:44:18.020 --> 00:44:19.020 Okay, thank you. 00:44:19.020 --> 00:44:20.020 Okay, good night. 00:44:20.020 --> 00:44:22.020 Okay, for those people who've listened, thanks so much for listening, 00:44:22.020 --> 00:44:26.020 and for those callers that called in, thanks for putting your questions in. 00:44:26.020 --> 00:44:28.020 We always appreciate questions. 00:44:28.020 --> 00:44:32.020 It lets us know that people are out there listening, apart from anything else. 00:44:32.020 --> 00:44:40.020 Okay, so for people that want to find out more about Dr. Peat, www.raypeat.com, R-A-Y, P-E-A-T, 00:44:40.020 --> 00:44:45.020 has a wide list, reading list of published material that's fully referenced.