WEBVTT 00:00:01.000 --> 00:00:03.000 Well, welcome to this month's Ask Your Herb Doctor. 00:00:03.000 --> 00:00:04.000 My name's Andrew Murray. 00:00:04.000 --> 00:00:06.000 My name's Sarah Johanneson Murray. 00:00:06.000 --> 00:00:09.000 For those of you who perhaps have never listened to the shows, 00:00:09.000 --> 00:00:13.000 they run every third Friday of the month from 7 to late p.m. 00:00:13.000 --> 00:00:16.000 We're both licensed medical herbalists who trained in England, 00:00:16.000 --> 00:00:19.000 graduating there with a degree in herbal medicine, 00:00:19.000 --> 00:00:22.000 and we run a clinic in Garboville where we consult with clients 00:00:22.000 --> 00:00:27.000 about a wide range of conditions and recommend supplements and nutritional counselling. 00:00:27.000 --> 00:00:31.000 You're listening to Ask Your Herb Doctor on KMED Garboville, 91.1 FM, 00:00:31.000 --> 00:00:34.000 and from 7.30 until the end of the show at 8 o'clock, 00:00:34.000 --> 00:00:38.000 you're invited to call in with any questions, either related or unrelated, 00:00:38.000 --> 00:00:45.000 to this month's subject of antioxidant theory and the continued war on cancer. 00:00:45.000 --> 00:00:50.000 The number here, if you live in the area, is 923 3911, 00:00:50.000 --> 00:00:57.000 and there's an 800 number, which is 1-800-568-3723 for those outside the area 00:00:57.000 --> 00:01:00.000 and also for those people listening on the web. 00:01:00.000 --> 00:01:06.000 So www.kmed.org, and this show is streaming live, 00:01:06.000 --> 00:01:10.000 so I think many of our people that come from the Midwest and the East Coast 00:01:10.000 --> 00:01:13.000 are probably listening to this on the web. 00:01:13.000 --> 00:01:18.000 We can be reached, incidentally, toll-free on 1-888-WBM-HERB 00:01:18.000 --> 00:01:23.000 for consultations or any further information at the end of the show 00:01:23.000 --> 00:01:28.000 and/or Monday through Friday, 9-5. 00:01:28.000 --> 00:01:34.000 So I wanted to open up with a little repeat or a paraphrase 00:01:34.000 --> 00:01:42.000 of some of our previous discussions with Dr. Peat, both in July and in May. 00:01:42.000 --> 00:01:50.000 So U.S. Vice President Joe Biden addresses the session "Cancer Moonshot, a Call to Action" 00:01:50.000 --> 00:01:55.000 during the annual meeting of the World Economic Forum in Davos, Switzerland, 00:01:55.000 --> 00:01:58.000 January 19, 2016. 00:01:58.000 --> 00:02:03.000 Biden, whose son Beau died last year at the age of 46 from brain cancer, 00:02:03.000 --> 00:02:06.000 has helped fuel Biden's sense of urgency about the project, 00:02:06.000 --> 00:02:13.000 which was first announced by President Barack Obama in his State of the Union address in January. 00:02:13.000 --> 00:02:17.000 In July's program we discussed your newsletter, Dr. Peat, 00:02:17.000 --> 00:02:20.000 entitled "100 Years of Cancer Metabolism," 00:02:20.000 --> 00:02:27.000 which outlined the stark contrast between the objective and scientific inquiry-based approach to disease 00:02:27.000 --> 00:02:35.000 exemplified by early 20th century biologists like Otto Warburg, Albert Szent-Györgyi, William F. Koch, 00:02:35.000 --> 00:02:41.000 and the mechanistic, cancercidal approaches of the multibillion-dollar cancer industry, 00:02:41.000 --> 00:02:44.000 which has failed spectacularly to find a cure for cancer, 00:02:44.000 --> 00:02:49.000 and whose funding continues to grow disproportionate to any other industry, 00:02:49.000 --> 00:02:56.000 whose ability to prove "good" on their research funding would normally cause their exit from the marketplace. 00:02:56.000 --> 00:03:02.000 It is more a matter of continuing the war and the money generated in cancer's feared diagnosis, 00:03:02.000 --> 00:03:04.000 which perpetuates the industry. 00:03:04.000 --> 00:03:08.000 Cures are really not very profitable, nor self-perpetuating. 00:03:08.000 --> 00:03:15.000 Thus, misled strategies to conquer cancer prevail against the truly objective and scientific discourses of yesteryear, 00:03:15.000 --> 00:03:20.000 with the emergence of globalistic monopolies with different objectives to truly curing anything, 00:03:20.000 --> 00:03:23.000 but continuing to play both sides of the war, 00:03:23.000 --> 00:03:28.000 not unlike real wars, so waged by corrupt governments and corrupt politicians alike. 00:03:28.000 --> 00:03:33.000 The free radical theory of aging was conceived by Denham Harmon in the 50s, 00:03:33.000 --> 00:03:40.000 when a prevailing scientific opinion held that free radicals were too unstable to exist in biological systems. 00:03:40.000 --> 00:03:43.000 Two sources inspired Harmon. 00:03:43.000 --> 00:03:48.000 One was the rate-of-living theory, which holds that the lifespan is an inverse function of metabolic rate, 00:03:48.000 --> 00:03:52.000 which in turn is proportional to oxygen consumption, 00:03:52.000 --> 00:03:58.000 and to Rebecca Gershman's observation that hyperbaric oxygen toxicity and radiation toxicity 00:03:58.000 --> 00:04:03.000 could be explained by the same underlying phenomena, i.e. oxygen-free radicals. 00:04:03.000 --> 00:04:09.000 Now, Harmon's hypothesis has been seriously challenged by recent studies showing that reactive oxygen species 00:04:09.000 --> 00:04:15.000 actually evoke metabolic health and longevity, and as for Rebecca Gershman's observation, 00:04:15.000 --> 00:04:20.000 it's interesting that Joseph Priestley, the English chemist who discovered oxygen in 1774, 00:04:20.000 --> 00:04:26.000 had questioned whether the gas, which is so essential to life, might also in some way be harmful. 00:04:26.000 --> 00:04:30.000 Modern research has revealed that oxygen is actually a very toxic material, 00:04:30.000 --> 00:04:34.000 and that the body has a number of antioxidant defense systems that act continuously 00:04:34.000 --> 00:04:37.000 to keep tissue oxygen levels from getting too high. 00:04:37.000 --> 00:04:44.000 One of the built-in systems that accomplishes this is the enzyme superoxide dismutase 00:04:44.000 --> 00:04:49.000 discovered by Erwin Fridowicz and Joe McCord in '67. 00:04:49.000 --> 00:04:54.000 It begets the question why the neurosis in the ICU of most hospitals, 00:04:54.000 --> 00:04:57.000 if your oxygen saturation is lower than 97%, 00:04:57.000 --> 00:05:02.000 they poison you with pure oxygen when it's common knowledge that increased CO2 is protective. 00:05:02.000 --> 00:05:06.000 Like the previous show in May, where Dr. Peake's newsletter explained 00:05:06.000 --> 00:05:10.000 and explored the societal paranoia versus trust-annoyer, 00:05:10.000 --> 00:05:15.000 referring to the government's working for our benefit to keep us safe from disease, etc., 00:05:15.000 --> 00:05:21.000 Dr. Peake displayed evidence contrary to this related to cancer therapies ignoring objective science, 00:05:21.000 --> 00:05:25.000 but rather a creasing to rank order within academia. 00:05:25.000 --> 00:05:29.000 And now, Dr. Peake, you've uncovered research which shows a different perspective 00:05:29.000 --> 00:05:35.000 to our previous understanding of antioxidants and how they should actually be referred to as pro-oxidants 00:05:35.000 --> 00:05:37.000 and how that affects the organism. 00:05:37.000 --> 00:05:40.000 So thank you so much for joining us again, Dr. Peake. 00:05:40.000 --> 00:05:41.000 You're welcome. 00:05:41.000 --> 00:05:45.000 For those people, as always, who may have not listened to our show, 00:05:45.000 --> 00:05:50.000 would you outline your academic and professional background for those people listening? 00:05:50.000 --> 00:05:52.000 I appreciate that. 00:05:52.000 --> 00:06:00.000 My biology study was at the University of Oregon, 1968 to '72, 00:06:00.000 --> 00:06:07.000 where I worked on my thesis on reproductive aging 00:06:07.000 --> 00:06:13.000 and the oxidative metabolic changes that are involved in aging. 00:06:13.000 --> 00:06:24.000 And at that time, I was really just bringing together information on oxidative metabolism 00:06:24.000 --> 00:06:28.000 that had been developed over the preceding 50 years. 00:06:28.000 --> 00:06:38.000 And I thought the situation was ripe for sort of a conclusion. 00:06:38.000 --> 00:06:44.000 I, at the time, couldn't have imagined that 45 years later, 00:06:44.000 --> 00:06:51.000 it would have gone backward to the 1890s situation of the government 00:06:51.000 --> 00:06:59.000 pushing a purely genetic causation of cancer and other diseases. 00:06:59.000 --> 00:07:02.000 Now, Harmon's hypothesis would have been relevant at that time. 00:07:02.000 --> 00:07:09.000 You said in the '50s, the early or mid '50s, you were doing this kind of post-grad work? 00:07:09.000 --> 00:07:19.000 Yeah, in the 1950s, there were lots of new discoveries. 00:07:19.000 --> 00:07:27.000 Daniel Mazia and his collaborator Katsuma Dan 00:07:27.000 --> 00:07:34.000 discovered how the mitotic apparatus works, the controlled cell division, 00:07:34.000 --> 00:07:41.000 and they found that the reduction of the sulfur groups, sulfhydryls, 00:07:41.000 --> 00:07:45.000 increased at the time of cell division. 00:07:45.000 --> 00:07:53.000 And if you look at those as the interface between metabolic energy production 00:07:53.000 --> 00:07:57.000 and cell growth and differentiation, 00:07:57.000 --> 00:08:07.000 it suggests a very direct course to curing the tumor-producing diseases at least 00:08:07.000 --> 00:08:13.000 and the inflammatory diseases by working on metabolism. 00:08:13.000 --> 00:08:21.000 The genes are only in the background, don't have any role in therapy actually, 00:08:21.000 --> 00:08:25.000 except everyone has to have genes. 00:08:25.000 --> 00:08:28.000 We have to produce proteins and everything else. 00:08:28.000 --> 00:08:32.000 Okay, we'll get into a little bit later how the gene theory has been totally discredited 00:08:32.000 --> 00:08:38.000 in a lot of ways in terms of the evidence that we'll bring out in some of these abstracts. 00:08:38.000 --> 00:08:44.000 But in terms of what interested me when I started reading these abstracts and articles 00:08:44.000 --> 00:08:50.000 was that I think a lot of people recognize the term "oxidant" and "antioxidant" 00:08:50.000 --> 00:08:55.000 probably erroneously and we've always looked at antioxidants as being the things 00:08:55.000 --> 00:09:01.000 we were necessarily looking for when in fact when they've done autopsies in the brain, 00:09:01.000 --> 00:09:05.000 they find things like glutathione, which is one of the main antioxidants in the system, 00:09:05.000 --> 00:09:12.000 is actually not that depleted and so they're looking at other reasons for aging and cell death, etc. 00:09:12.000 --> 00:09:19.000 How is your current understanding of antioxidants different? 00:09:19.000 --> 00:09:25.000 Because essentially what I think you're trying to say was that antioxidants really should be termed, 00:09:25.000 --> 00:09:29.000 sorry, antioxidants should really be termed "proxidants." 00:09:29.000 --> 00:09:38.000 Yeah, the ones that are therapeutically useful, such as vitamin E and vitamin C, 00:09:38.000 --> 00:09:42.000 actually shift the balance inside the cell. 00:09:42.000 --> 00:09:50.000 Vitamin C is known to be in a very highly oxidized condition, so it isn't really the vitamin C we know. 00:09:50.000 --> 00:09:55.000 It's a dehydroascorbate when it is inside the healthy cell. 00:09:55.000 --> 00:10:04.000 And these are maintaining, it's actually a constant flow of electrons, 00:10:04.000 --> 00:10:15.000 but the balance at every moment is pushed in the direction closer to oxygen and farther from the reducing electrons. 00:10:15.000 --> 00:10:20.000 And so if you're deficient in vitamin E and vitamin C and so on, 00:10:20.000 --> 00:10:32.000 the electrons predominate and shift over to reducing the sulfur groups all through the cell 00:10:32.000 --> 00:10:37.000 into the sulfhydryl form, promoting inflammation. 00:10:37.000 --> 00:10:42.000 And if you think about what happens when any kind of injury happens, 00:10:42.000 --> 00:10:49.000 whether it's a microbe or getting stuck with a thorn or whatever, 00:10:49.000 --> 00:11:01.000 you disrupt the ability of the organized tissue to deliver oxygen and sugar and other nutrients to the cell. 00:11:01.000 --> 00:11:07.000 And so the cell in that area is starved, can't oxidize, 00:11:07.000 --> 00:11:16.000 and it has an immediate shift over to basically the antioxidant side. 00:11:16.000 --> 00:11:32.000 The cell has a variety of enzymes that function as antioxidants, but they are only activated during injury or stress. 00:11:32.000 --> 00:11:39.000 And what happens to the cells in that condition is the sulfhydryls are reduced, 00:11:39.000 --> 00:11:49.000 the mitotic apparatus is activated, the cells de-differentiate, lose their functions except to grow and divide and move. 00:11:49.000 --> 00:11:57.000 So they creep into the injured area and multiply to repair the area. 00:11:57.000 --> 00:12:07.000 And then if the surrounding organism is able to deliver oxygen and sugar and other nutrients, 00:12:07.000 --> 00:12:13.000 then they are able to differentiate and finish the healing process. 00:12:13.000 --> 00:12:19.000 So this whole theory of antioxidant, that we don't want to oxidize things, 00:12:19.000 --> 00:12:27.000 is really we want the cell to be oxidizing and an injured cell is not using the oxygen. 00:12:27.000 --> 00:12:30.000 It's actually in an anti-oxygen state. 00:12:30.000 --> 00:12:39.000 Yeah, and if you get stuck in the antioxidant state, that keeps the healing process from being completed. 00:12:39.000 --> 00:12:42.000 And that's where cancer is. 00:12:42.000 --> 00:12:53.000 It's stuck in the inflamed antioxidant state, only able to divide without knowing exactly what it should be doing. 00:12:53.000 --> 00:13:03.000 So how can we understand how CoQ10 and naringenin and apigenin are actually working on the inside of the cell? 00:13:03.000 --> 00:13:08.000 The apigenin and naringenin from like orange peel, marmalade and celery seeds. 00:13:08.000 --> 00:13:10.000 And apigenin from celery seeds. 00:13:10.000 --> 00:13:16.000 Those potent antioxidants, as we're told, they're antioxidants, but how are they actually working in the cell? 00:13:16.000 --> 00:13:28.000 Well, the coenzyme Q10 is now known to fit very specifically in certain places in the mitochondria 00:13:28.000 --> 00:13:35.000 that deliver electrons to the electron transport system, 00:13:35.000 --> 00:13:46.000 delivering it ultimately to oxygen to complete the production of ATP and carbon dioxide. 00:13:46.000 --> 00:13:50.000 So it plugs right into the oxidative system. 00:13:50.000 --> 00:13:52.000 So it's actually oxidizing. 00:13:52.000 --> 00:14:02.000 It's oxidizing everything upstream to deliver those electrons into the oxidizing pigments, 00:14:02.000 --> 00:14:05.000 which deliver the electrons to oxygen. 00:14:05.000 --> 00:14:14.000 So it's a necessary link between oxygen and all of the reducing factors. 00:14:14.000 --> 00:14:28.000 So if you don't have that link, that's one of the essential links that you need to prevent the electrons from going into the growth cell division system. 00:14:28.000 --> 00:14:32.000 Right, because if they don't have, if the cells don't have enough oxygen, 00:14:32.000 --> 00:14:39.000 then they'll start dividing and potentially becoming cancerous if they don't get that oxygen and the oxidizing process happening. 00:14:39.000 --> 00:14:54.000 Yeah, and where the actual antioxidant function comes in is when you have an oversupply of polyunsaturated fats, for example. 00:14:54.000 --> 00:15:03.000 When you don't have enough oxygen and go into that inflamed cell division state, 00:15:03.000 --> 00:15:15.000 the electrons that can't be taken up by oxygen are free to locate on iron atoms, for example. 00:15:15.000 --> 00:15:23.000 And the iron, when it's reduced, there's always some potential iron. 00:15:23.000 --> 00:15:29.000 But the older you are, the more free iron there is likely to be in your cells. 00:15:29.000 --> 00:15:37.000 The electrons activate the iron, which then attacks any of the polyunsaturated fats in the environment. 00:15:37.000 --> 00:15:47.000 And that sets up an oxygen-consuming system, which produces nothing of value. 00:15:47.000 --> 00:15:58.000 The electrons have no place proper to go, so they go to iron, which then gives its electron to the polyunsaturated fat, 00:15:58.000 --> 00:16:10.000 which becomes a free radical and consumes, reacts directly, then sometimes with oxygen or with more iron. 00:16:10.000 --> 00:16:16.000 And you get cycles of oxidation without purpose. 00:16:16.000 --> 00:16:21.000 Right, okay, so you want the oxidation to be in the cell producing carbon dioxide using sugar and oxygen 00:16:21.000 --> 00:16:27.000 and the whole proper cellular respiration to be going on, not to where you're in this reduced state 00:16:27.000 --> 00:16:33.000 where your body, the PUFA, the polyunsaturated fats are so hungry for oxygen and so is the iron, 00:16:33.000 --> 00:16:37.000 and so those things are oxidizing and not producing. Is that a good way to understand it? 00:16:37.000 --> 00:16:46.000 Yeah, and in the process of consuming oxygen, they are creating oxygen starvation. 00:16:46.000 --> 00:16:52.000 And so they're setting up the situation to spread. 00:16:52.000 --> 00:16:55.000 So it's a very energy-wasteful situation. 00:16:55.000 --> 00:16:57.000 Yeah, an oxygen-wasting system. 00:16:57.000 --> 00:17:03.000 Is that because the polyunsaturates will attract the oxygens more strongly than the respiring cell? 00:17:03.000 --> 00:17:08.000 Yeah, they become a trap for oxygen. 00:17:08.000 --> 00:17:20.000 And as they deteriorate, they interact with the iron and proteins and create imitation oxidative enzymes, 00:17:20.000 --> 00:17:27.000 except as a short circuit directly between NADH and oxygen, 00:17:27.000 --> 00:17:37.000 by way of the iron and proteins that are condensed in the form of age pigment or lipoflaskin, 00:17:37.000 --> 00:17:44.000 made up of polyunsaturated fats and parts of the cell which have been destroyed. 00:17:44.000 --> 00:17:49.000 And so those function as a very powerful oxygen sink, 00:17:49.000 --> 00:17:54.000 keeping the mitochondria from getting the oxygen they need. 00:17:54.000 --> 00:17:59.000 So that's why you don't want to eat fried foods that are fried in liquid vegetable oils, 00:17:59.000 --> 00:18:05.000 because you're going to create oxygen starvation for your cells that need the oxygen, 00:18:05.000 --> 00:18:08.000 because the vegetable oil is going to soak it all up. 00:18:08.000 --> 00:18:16.000 Yeah, and with time, as that process accumulates, for example, 00:18:16.000 --> 00:18:23.000 small amounts of practically invisible of the age pigment begin accumulating 00:18:23.000 --> 00:18:32.000 and keeping those cells in a state in which they take up preferentially more of the polyunsaturated fats, 00:18:32.000 --> 00:18:34.000 if they're available. 00:18:34.000 --> 00:18:42.000 And so with age, organs like the brain, which are normally very high energy users, 00:18:42.000 --> 00:18:54.000 become slowed down and reduced and preferentially concentrate more and more of the highly unsaturated fats, 00:18:54.000 --> 00:19:02.000 especially DHA, the predominant fat in fish oil, 00:19:02.000 --> 00:19:06.000 concentrates more and more in the brain with age 00:19:06.000 --> 00:19:13.000 and makes the brain more and more susceptible to the lipid peroxidation 00:19:13.000 --> 00:19:20.000 and losing function because the oxygen is being diverted. 00:19:20.000 --> 00:19:25.000 Yeah, and it's the byproducts of that lipid peroxidation which are themselves very damaging. 00:19:25.000 --> 00:19:31.000 Yeah, and tends to produce more of the age pigment. 00:19:31.000 --> 00:19:43.000 So what is cumulative is the catalytic products of the degenerating polyunsaturates 00:19:43.000 --> 00:19:48.000 and not specifically mutations in the mitochondria, 00:19:48.000 --> 00:19:54.000 which the Harmon free radical theory of aging insisted on. 00:19:54.000 --> 00:19:56.000 Right. Okay, good. 00:19:56.000 --> 00:20:02.000 Let me hold you there. You're listening to Ask Your Doctor, KMED, Gallivaville, 91.1 FM. 00:20:02.000 --> 00:20:11.000 We're very pleased to have Dr. Raymond Peat with us exploring the latest concepts in oxidants, antioxidants, cancer theory. 00:20:11.000 --> 00:20:16.000 The lines will be open from 7.30 to 8 o'clock if callers would like to call in with any questions 00:20:16.000 --> 00:20:21.000 either related to this month's subject or to other relevant subjects surrounding health. 00:20:21.000 --> 00:20:25.000 The number here for in the area is 923 3911. 00:20:25.000 --> 00:20:32.000 Well, there's an 800 number for those out of state, perhaps 800 568 3723. 00:20:32.000 --> 00:20:36.000 Dr. Peat, you brought up an interesting point here, Lipofruskin. 00:20:36.000 --> 00:20:42.000 So I know we've mentioned it many times in the past in reference to fish oils, 00:20:42.000 --> 00:20:45.000 which unfortunately are still portrayed as being very healthful 00:20:45.000 --> 00:20:50.000 and is still a very multi-billion dollar industry for certain corporations. 00:20:50.000 --> 00:20:53.000 Obviously, these things take a long time before they reach the mainstream 00:20:53.000 --> 00:20:58.000 and people understand that what they're doing for themselves is actually very harmful. 00:20:58.000 --> 00:21:03.000 So I was thinking about the link and it's a little bit of a kind of curveball, 00:21:03.000 --> 00:21:10.000 but the outbreak of Zika, let's just explore. 00:21:10.000 --> 00:21:13.000 I haven't really prepared. I know you haven't prepared for it, 00:21:13.000 --> 00:21:19.000 but I know you've normally got a very different perspective at which to approach a problem. 00:21:19.000 --> 00:21:24.000 So in terms of Zika and the prevalence of microcaffeine, 00:21:24.000 --> 00:21:35.000 if that indeed is a manifestation of Zika only, I was looking earlier on just at Lipofruskin in general. 00:21:35.000 --> 00:21:41.000 I came across the term neuronal steroid Lipofruskinosis. 00:21:41.000 --> 00:21:49.000 Now, steroid apparently is a product that's produced as a result of the inability to remove Lipofruskin. 00:21:49.000 --> 00:21:54.000 And there were apparently there are eight types or so they've recognized these types or subtypes, 00:21:54.000 --> 00:21:58.000 genetically separate neurodegenerative disorders that result, 00:21:58.000 --> 00:22:02.000 as I said, from the excessive accumulation of the pigment Lipofruskin. 00:22:02.000 --> 00:22:05.000 Now, with reference, like I said, to steroid, 00:22:05.000 --> 00:22:10.000 it apparently is formed when a disposal system for Lipofruskin is overloaded. 00:22:10.000 --> 00:22:19.000 But what caught my attention was that they had eight types and types one, two and three were associated with microcaffeine. 00:22:19.000 --> 00:22:27.000 And I know that without bringing up this or changing the subject of this month's show to Zika and the, you know, 00:22:27.000 --> 00:22:31.000 the political ramifications and or the conspiracy theories about Zika. 00:22:31.000 --> 00:22:39.000 In terms of microcaffeine in the infantile brain developing in utero with reference to polyunsaturates 00:22:39.000 --> 00:22:46.000 and the production of Lipofruskin and or the inability to remove the waste producing Lipofruskinosis. 00:22:46.000 --> 00:22:59.000 How do you how do you see microcaffeine in the kind of in the overall picture for the explanation of what Zika does to infantile children? 00:22:59.000 --> 00:23:08.000 Well, it could be a virus like that, or it could be the insecticide that people absorb when they're spraying the mosquitoes that carry the virus. 00:23:08.000 --> 00:23:16.000 The insecticides are known to damage brain development. 00:23:16.000 --> 00:23:23.000 But 50 years ago with experiments in mice and then a little later in dogs, 00:23:23.000 --> 00:23:34.000 they found that in proportion to the unsaturation of the fat in the mother's diet, the brain development was retarded. 00:23:34.000 --> 00:23:47.000 The animal, the baby animals had smaller brains and were less able to learn in proportion to the amount of prenatal polyunsaturated fat they absorbed. 00:23:47.000 --> 00:23:55.000 Because isn't it true that the placenta will try and filter out all of the polyunsaturated fat from the mother's diet? 00:23:55.000 --> 00:24:01.000 Yeah, the placenta preferentially absorbs glucose and fructose. 00:24:01.000 --> 00:24:09.000 But if the diet if the mother happens to have low blood glucose, 00:24:09.000 --> 00:24:22.000 then more of the mother's circulating fats as your blood sugar goes down, you liberate into the bloodstream free fatty acids. 00:24:22.000 --> 00:24:33.000 So when the mother has hypoglycemia, the placenta loses the ability to screen out the fats to some extent, 00:24:33.000 --> 00:24:39.000 where the baby should make its own brain fats purely from glucose. 00:24:39.000 --> 00:24:44.000 And those would be saturated fats. Those wouldn't be polyunsaturated fats, correct? 00:24:44.000 --> 00:24:57.000 Primarily saturated, but then we intrinsically are able to make a series of polyunsaturated fats called the omega minus nine series. 00:24:57.000 --> 00:25:08.000 And those are present in any healthy baby's brain, whether it's a human or a cow or a bird or rodent. 00:25:08.000 --> 00:25:18.000 The developing brain turns sugar into saturated fats and the omega minus nine series. 00:25:18.000 --> 00:25:24.000 And the brain is predominantly lipid in its structure? 00:25:24.000 --> 00:25:31.000 About 50% fat, very high fat content compared to other tissues. 00:25:31.000 --> 00:25:39.000 OK, so another thing that came out looking at the breakdown of the different subtypes of lipofuscinosis, 00:25:39.000 --> 00:25:49.000 were those that were associated positively with epilepsy, either childhood epilepsy, midlife or late life epilepsy. 00:25:49.000 --> 00:25:55.000 How do you how do you see epilepsy in relation to polyunsaturates in the diet? 00:25:55.000 --> 00:26:07.000 Vitamin E has been proven to reduce the incidence of seizures in lots of animal experiments. 00:26:07.000 --> 00:26:20.000 And the process of stress in a brain cell lowers the oxygen availability, 00:26:20.000 --> 00:26:27.000 triggers that reductive process causing lipid peroxidation. 00:26:27.000 --> 00:26:36.000 And if your tissues are well saturated with vitamin E, that's much less likely to happen. 00:26:36.000 --> 00:26:46.000 OK, so let's let's move on to a couple of other examples of the evidence that's been disproven 00:26:46.000 --> 00:26:53.000 in terms of mitochondrial energy production, mitochondrial health, the theory of aging. 00:26:53.000 --> 00:27:04.000 There are instances, well not instances, it's very well documented knowledge that parrots are very long lived compared to quail, for example. 00:27:04.000 --> 00:27:13.000 And there's a naked mole rat which lives for 32 years compared to regular mice that live for three years. 00:27:13.000 --> 00:27:26.000 In terms of the metabolic energy of an organism to deal with insults, essentially, by having the energy to overcome that in the system. 00:27:26.000 --> 00:27:37.000 What do you what do you have to say about the longevity of different species that exist even within the same species? 00:27:37.000 --> 00:27:42.000 So the parrots and the quail and the mole rat and the regular mouse? 00:27:42.000 --> 00:27:46.000 Well, flamingos also long live, yeah. 00:27:46.000 --> 00:28:03.000 There are a few researchers who have surveyed a lot of different animals and found that the highly unsaturated animals in the given species 00:28:03.000 --> 00:28:09.000 don't live as long as those less highly unsaturated. 00:28:09.000 --> 00:28:14.000 Hulbert and Pamplona are two of the people who have done the most research. 00:28:14.000 --> 00:28:24.000 And they find that birds in general are much less unsaturated in all their tissues than mammals. 00:28:24.000 --> 00:28:37.000 And part of that is that they don't activate enzymes that extend, for example, linoleic acid in a mammal. 00:28:37.000 --> 00:28:54.000 It's processed to remove electrons until it can, with the addition of more carbons, can become EPA or DHA, the highly unstable polyunsaturated. 00:28:54.000 --> 00:28:59.000 The birds simply don't use those enzymes to the extent that mammals do. 00:28:59.000 --> 00:29:03.000 So they can eat a polyunsaturated and it just doesn't turn into the EPA or the DHA. 00:29:03.000 --> 00:29:15.000 Yeah, so they have more of the unprocessed linoleic acid than the highly unstable longer ones. 00:29:15.000 --> 00:29:23.000 And part of that, I think, is because they live at a much higher body temperature than mammals. 00:29:23.000 --> 00:29:37.000 Mammals are usually somewhere between 90 and 100 degrees Fahrenheit, and the birds generally are well over 100 degrees Fahrenheit, up to as much as 110 degrees. 00:29:37.000 --> 00:30:00.000 And that means that they will very quickly oxidize any of the most unstable fats. If they eat something with a highly unsaturated fat, it's more likely that the fat will be used for energy rather than circulating to cause trouble. 00:30:00.000 --> 00:30:09.000 So how about the decreased problems with PUFA in the presence of higher temperature? 00:30:09.000 --> 00:30:22.000 You're saying that just purely the higher temperature could cause PUFA to be oxidized more rapidly and therefore not within the cell but actually within a GI tract or elsewhere? 00:30:22.000 --> 00:30:28.000 He's just saying it's not going to get stored and it will get used up for fuel right away because their metabolism is so fast. 00:30:28.000 --> 00:30:43.000 Yeah, even in a mammal at say 98 degrees, it turns out that a very high proportion of the DHA breaks down even by the time it gets into the bloodstream. 00:30:43.000 --> 00:30:57.000 And it's the breakdown products that act on the immune system to suppress inflammation by temporarily stopping the production of prostaglandins. 00:30:57.000 --> 00:31:05.000 Okay, we actually have a couple of callers, so let's start in with our first caller. Caller, you're on the air. Where are you from? 00:31:05.000 --> 00:31:09.000 Okay, me already? 00:31:09.000 --> 00:31:11.000 Yeah, I can hear you now. Where are you from, caller? 00:31:11.000 --> 00:31:18.000 Okay, hi. Well, I'm calling you from way, way far away. I'm calling you from Finland in Europe. 00:31:18.000 --> 00:31:21.000 Finland, excellent. 00:31:21.000 --> 00:31:26.000 The sun hasn't risen yet and it will not rise for another couple of hours. 00:31:26.000 --> 00:31:31.000 Good to hear your voice from Finland. All the best. What's your question for Dr. Peat? 00:31:31.000 --> 00:31:40.000 Well, I'd like to first thank you for the show and I'd like your opinion about two very different types of devices. 00:31:40.000 --> 00:31:49.000 The first one are the so-called PEMF devices like Earth Pulse, Delta Sleep. 00:31:49.000 --> 00:31:56.000 The goal would be to induce Delta Sleep in a 46-year-old male as myself. 00:31:56.000 --> 00:32:05.000 And the second type of device I'd like your opinion on is CO2 breathing machines and CO2 bath devices. 00:32:05.000 --> 00:32:13.000 Okay, well, the CO2 question, no problem. The first one, Dr. Peat, have you heard of this device, a PEMF? 00:32:13.000 --> 00:32:15.000 No, I don't know what it means. 00:32:15.000 --> 00:32:21.000 Can you, caller, can you just elaborate a little bit on the fundamentals of this? 00:32:21.000 --> 00:32:30.000 Sure. So those are, I think, in the PEMF there must be EM, must be electromagnetic field. 00:32:30.000 --> 00:32:31.000 So it's EMF, right. 00:32:31.000 --> 00:32:45.000 They are devices that you wear on your upper chest and they're supposed to deliver some light pulsing electromagnetic signal to induce deep sleep like Delta Sleep. 00:32:45.000 --> 00:32:51.000 Okay, interesting. Dr. Peat, what do you think about that EMF generator? 00:32:51.000 --> 00:33:03.000 About 40 years ago, there was research on stimulating the brain across from one temple to the other with gentle, 00:33:03.000 --> 00:33:18.000 just one or two volts and very few microamps of current would be enough to induce those slower rhythms of the brain and improve sleep. 00:33:18.000 --> 00:33:23.000 But I don't know what the present apparatus is. 00:33:23.000 --> 00:33:29.000 Do you know, sir, do you know what the volts are of the machine you're dispensing? 00:33:29.000 --> 00:33:33.000 I think that we're in a 10. 00:33:33.000 --> 00:33:39.000 Now, I'm not sure about the hertz and the micro and mega, but something around 10. 00:33:39.000 --> 00:33:43.000 Let me check. 00:33:43.000 --> 00:33:59.000 So basically, the latest devices seem to be, have to be worn on some artery between the heart and one of the sides, like the arm. 00:33:59.000 --> 00:34:11.000 And I think it's something like 10 hertz or something like that, but I'm not sure about the, yeah, 00:34:11.000 --> 00:34:17.000 you can vary them from 1 to 14 hertz, but they recommend mostly around 10, 8 or 10 hertz. 00:34:17.000 --> 00:34:20.000 10 is a natural frequency for humans. 00:34:20.000 --> 00:34:27.000 Okay, well, I don't know if we can expand too much on that, but definitely can with the CO2 question. 00:34:27.000 --> 00:34:32.000 So your main question about the CO2 was? 00:34:32.000 --> 00:34:39.000 Yeah, so now I can see, for example, on the Ray Peat Forum, there are people doing all kinds of experiments. 00:34:39.000 --> 00:34:49.000 And one of them being to basically bathe, well, there are breathing machines where you can regulate how much CO2 you're getting. 00:34:49.000 --> 00:34:55.000 And then one gentleman even invented some kind of bath device. 00:34:55.000 --> 00:35:00.000 So it's like a huge plastic balloon that you wrap around yourself. 00:35:00.000 --> 00:35:10.000 And there's something for access to or for infusing yourself basically with CO2, and this can be worn for hours. 00:35:10.000 --> 00:35:19.000 Yeah, we've used that with our clients with injury that they wrap their injured limb in a plastic bag that they filled up with pure carbon dioxide. 00:35:19.000 --> 00:35:31.000 It certainly increases the vasodilation and gives you that sense of warmth that you'd either get from CO2 gas or being in these soda waters that liberate CO2. 00:35:31.000 --> 00:35:34.000 I know Dr. Peat's got a lot to say about carbon dioxide. 00:35:34.000 --> 00:35:39.000 Let me let you say what you want to say about CO2, Dr. Peat, though you're always more eloquent. 00:35:39.000 --> 00:35:52.000 I think it was in 1908 that someone wrote an article about the medical uses of both treating colon inflammation, 00:35:52.000 --> 00:35:59.000 vaginal inflammation and such with the actual application of the gas or filling a bathtub. 00:35:59.000 --> 00:36:09.000 Since CO2 is heavier than air, if you seal the drains on a bathtub, you can just fill the bathtub with it and get in. 00:36:09.000 --> 00:36:14.000 And the person said an hour in the bathtub was like a day at the beach. 00:36:14.000 --> 00:36:17.000 You could probably leave your clothes on as well, couldn't you? 00:36:17.000 --> 00:36:21.000 Yeah, you don't have to take your clothes off because it instantly goes right through the clothing. 00:36:21.000 --> 00:36:28.000 You can feel it as a warm sensation because it relaxes blood vessels in the skin. 00:36:28.000 --> 00:36:35.000 And we have used huge plastic bags that come up to the shoulders. 00:36:35.000 --> 00:36:45.000 And you fill the bag and then get on a chair or something so you can step in it without spilling the CO2 00:36:45.000 --> 00:36:54.000 and pull it up around your body without spilling it and then tighten it around the top. 00:36:54.000 --> 00:37:07.000 And that will usually stay put for at least an hour and your skin gets pink and warm from the relaxing effect. 00:37:07.000 --> 00:37:10.000 And it has a systemic effect. 00:37:10.000 --> 00:37:17.000 It absorbs very quickly into your bloodstream and affects your blood pressure, 00:37:17.000 --> 00:37:25.000 improves pumping efficiency of your heart, reducing peripheral resistance in the arteries. 00:37:25.000 --> 00:37:29.000 Yeah, positively associated with good health. 00:37:29.000 --> 00:37:39.000 Yeah, and the increasing your CO2 lowers all of the transmitters of inflammation 00:37:39.000 --> 00:37:45.000 by shifting you out of the over-reduced electronic state. 00:37:45.000 --> 00:37:50.000 It suppresses lactic acid production, for example. 00:37:50.000 --> 00:37:55.000 It helps your mitochondria to use the oxygen quickly. 00:37:55.000 --> 00:37:58.000 Yeah, in many different ways. 00:37:58.000 --> 00:38:11.000 It activates the Krebs cycle and reduces meaningless excitation, lets you produce the energy in the right way 00:38:11.000 --> 00:38:15.000 rather than an inflamed, pointless way. 00:38:15.000 --> 00:38:21.000 Out of curiosity, can you drink sparkling water and would that help? 00:38:21.000 --> 00:38:26.000 Like internally as opposed to externally? 00:38:26.000 --> 00:38:34.000 You tend to burp it out and lose much of it, but the little bit you absorb is very helpful. 00:38:34.000 --> 00:38:39.000 I think that's one of the reasons why it's so calming on an upset stomach, right? Soda water or? 00:38:39.000 --> 00:38:48.000 Yeah, I think Priestley was really working on carbon dioxide when he accidentally discovered oxygen. 00:38:48.000 --> 00:38:53.000 Okay, good. Well, thank you for your call, Carla. We do have another caller on the air, so let's take this next caller. 00:38:53.000 --> 00:38:54.000 Where are you from, Carla? 00:38:54.000 --> 00:38:55.000 Hello? 00:38:55.000 --> 00:38:56.000 Hi, where are you from? 00:38:56.000 --> 00:38:57.000 Hi, near Philipsville. 00:38:57.000 --> 00:38:58.000 Okay, hi. What's your question? 00:38:58.000 --> 00:39:01.000 I have a couple of questions. 00:39:01.000 --> 00:39:05.000 Hello? Uh-oh. I think you've cut her off. Can you get her back? 00:39:05.000 --> 00:39:06.000 We've lost her. 00:39:06.000 --> 00:39:07.000 Can you hear me? 00:39:07.000 --> 00:39:08.000 Yeah, I can hear you now. 00:39:08.000 --> 00:39:14.000 Okay. Yeah, I've got two basic questions about the antioxidants. 00:39:14.000 --> 00:39:18.000 Number one, I want to get clear about what's good and what's bad. 00:39:18.000 --> 00:39:24.000 CoQ10, is that good or not? I've always heard that that was very good for your heart. 00:39:24.000 --> 00:39:26.000 Is that good or is that not good? 00:39:26.000 --> 00:39:27.000 It's very good. 00:39:27.000 --> 00:39:30.000 It is good. So it's good to take CoQ10. 00:39:30.000 --> 00:39:37.000 How much do you think -- I've been taking 100 milligrams a day. Is that a good amount? 00:39:37.000 --> 00:39:40.000 I don't think anyone really knows what the best amount is. 00:39:40.000 --> 00:39:43.000 You don't know the amount. Okay. Now, what about EPA? 00:39:43.000 --> 00:39:52.000 I've heard that EPA, as the vitamin -- not vitamin E, but the -- you know what I'm talking about. 00:39:52.000 --> 00:39:53.000 Fish oil. 00:39:53.000 --> 00:39:54.000 Yeah, probably unsaturated oil, yeah. 00:39:54.000 --> 00:40:00.000 Yeah. Is that good or bad? I heard that EPA was really good to support the heart function. 00:40:00.000 --> 00:40:04.000 Yeah, that's exactly the wrong kind of antioxidant. 00:40:04.000 --> 00:40:12.000 It's the reductive kind that imitates stress and promotes degenerative processes. 00:40:12.000 --> 00:40:16.000 So it's okay to have CoQ10 but not to have EPA? 00:40:16.000 --> 00:40:18.000 That's correct. 00:40:18.000 --> 00:40:23.000 And it also says that it supports your mood and is better for your brain function. 00:40:23.000 --> 00:40:24.000 Definitely. 00:40:24.000 --> 00:40:25.000 And you don't think that is it? 00:40:25.000 --> 00:40:27.000 No, definitely not better for your brain function. 00:40:27.000 --> 00:40:33.000 No, that was what we were discussing earlier and how an aging brain will have more and more of this EPA, 00:40:33.000 --> 00:40:37.000 which means that your brain actually gets less oxygen and it becomes more demented and more senile. 00:40:37.000 --> 00:40:39.000 And what about vitamin E? Is that good or not? 00:40:39.000 --> 00:40:43.000 Yeah, that's one of the main antioxidants Dr. Peat was outlining at the beginning of the show. 00:40:43.000 --> 00:40:44.000 It is a good one. 00:40:44.000 --> 00:40:45.000 Yeah, along with vitamin C. 00:40:45.000 --> 00:40:52.000 And vitamin K2 functions with coenzyme Q10 to deliver energy. 00:40:52.000 --> 00:40:55.000 And do you think glucosamine is good for the joints? 00:40:55.000 --> 00:40:56.000 Which? 00:40:56.000 --> 00:40:58.000 Glucosamine. 00:40:58.000 --> 00:41:01.000 Oh, I'm doubtful about that. 00:41:01.000 --> 00:41:09.000 It's been associated with changes in the pancreas like diabetes. 00:41:09.000 --> 00:41:12.000 Okay, so you're not sure about that one. 00:41:12.000 --> 00:41:14.000 All right, well, thank you very much. 00:41:14.000 --> 00:41:15.000 Thank you for your questions. 00:41:15.000 --> 00:41:28.000 Just last month an article came out by Sue and Yin identifying EPA and DHA as brain toxic fats. 00:41:28.000 --> 00:41:30.000 There you go. Good. 00:41:30.000 --> 00:41:32.000 I mean, the evidence is just so overwhelming. 00:41:32.000 --> 00:41:36.000 I don't know how people that listen to this show can possibly continue eating or taking this stuff. 00:41:36.000 --> 00:41:44.000 Anyway, it takes a long time sometimes for people to come to finally fully accept it. 00:41:44.000 --> 00:41:45.000 Well, there's so much mainstream media. 00:41:45.000 --> 00:41:46.000 It's just like with everything else. 00:41:46.000 --> 00:41:50.000 There's so much mainstream media telling you that EPA and DHA are good for your brain. 00:41:50.000 --> 00:41:51.000 Okay, we have another caller on the air. 00:41:51.000 --> 00:41:52.000 So let's take this next caller. 00:41:52.000 --> 00:41:53.000 Caller, where are you from? 00:41:53.000 --> 00:41:55.000 Hi, I'm from the San Francisco Bay Area. 00:41:55.000 --> 00:41:57.000 Hi, what's your question? 00:41:57.000 --> 00:42:03.000 Dr. Peat, I've noticed tremendous results by being on your nutrition program. 00:42:03.000 --> 00:42:09.000 I consult with Andrew Murray and things have been wonderful and even better now that I'm on thyroid hormones. 00:42:09.000 --> 00:42:12.000 My question is why are my eyes changing colors? 00:42:12.000 --> 00:42:16.000 I noticed they were brown and now they're getting lighter and lighter. 00:42:16.000 --> 00:42:24.000 My guess is they might become a hazel, but online a lot of people like raw vegan people on YouTube are saying that their eyes change from brown to blue, 00:42:24.000 --> 00:42:28.000 and I guess the lighter your eyes' color is, the healthier you are. 00:42:28.000 --> 00:42:32.000 So my question is why is this happening and is it true that the lighter color your eyes are, 00:42:32.000 --> 00:42:35.000 the healthier you are? 00:42:35.000 --> 00:42:45.000 I don't know about that, but I know that people who use prostaglandins, eye drops to treat glaucoma, 00:42:45.000 --> 00:42:50.000 very often have a darkening of the iris, 00:42:50.000 --> 00:43:01.000 and that I think is a directly toxic effect where the -- like ultraviolet light darkens your skin 00:43:01.000 --> 00:43:09.000 because it's injuring it and the pigment is a defensive reaction to protect you against ultraviolet light. 00:43:09.000 --> 00:43:15.000 I think the prostaglandin, which is made from polyunsaturated fats, 00:43:15.000 --> 00:43:21.000 is activating a defensive formation of pigment in the iris. 00:43:21.000 --> 00:43:31.000 So I suspect that it's good if you reduce your polyunsaturated fat intake and have lightening of your iris. 00:43:31.000 --> 00:43:35.000 I suspect it's a corrective process. 00:43:35.000 --> 00:43:37.000 Thank you very much. 00:43:37.000 --> 00:43:38.000 All right. 00:43:38.000 --> 00:43:39.000 Thank you for your call. 00:43:39.000 --> 00:43:40.000 Okay. 00:43:40.000 --> 00:43:42.000 We have another caller on the line, so let's take this next caller. 00:43:42.000 --> 00:43:44.000 Caller, where are you from? 00:43:44.000 --> 00:43:46.000 Yes, this is the first caller again. 00:43:46.000 --> 00:43:48.000 Thank you for letting me jump in line again. 00:43:48.000 --> 00:43:49.000 No problem. 00:43:49.000 --> 00:43:52.000 I had another question that came to mind. 00:43:52.000 --> 00:43:58.000 Does MCT oil do everything, every good thing that you recommend 00:43:58.000 --> 00:44:03.000 or that you say coconut oil can do from a health and metabolism point of view? 00:44:03.000 --> 00:44:08.000 So, Dr. Peat, medium-chain triglycerides, do they do the same thing as coconut oil? 00:44:08.000 --> 00:44:18.000 Yes, essentially they're doing the same thing of bypassing your stored polyunsaturated fats 00:44:18.000 --> 00:44:23.000 and letting you oxidize more safely the saturated fats. 00:44:23.000 --> 00:44:31.000 But one of the problems is that they are so mobile relative to the longer chains 00:44:31.000 --> 00:44:35.000 that they can be irritating to your stomach and intestines. 00:44:35.000 --> 00:44:40.000 You have to take it in a good balance with other foods. 00:44:40.000 --> 00:44:46.000 And that's why a lot of times these supplements like the vitamin D is in it, MCT oil, 00:44:46.000 --> 00:44:51.000 or the vitamin K, they can be irritating on people's digestion, 00:44:51.000 --> 00:44:55.000 and therefore then they can use those vitamins topically 00:44:55.000 --> 00:44:59.000 if they experience intestinal irritation from the MCTs. 00:44:59.000 --> 00:45:02.000 And that was another question, Dr. Peat, I wanted to ask you. 00:45:02.000 --> 00:45:07.000 Can you please describe the relation between vitamin K and cocutin? 00:45:07.000 --> 00:45:10.000 Is it a precursor for cocutin? 00:45:10.000 --> 00:45:15.000 It works at the same site in the mitochondrion, 00:45:15.000 --> 00:45:24.000 and it seems to just act as a stabilizer or amplifier of the effect of coenzyme Q10. 00:45:24.000 --> 00:45:26.000 So it's almost like if you take vitamin K, 00:45:26.000 --> 00:45:31.000 you're helping protect the cocutin that you have in your system? 00:45:31.000 --> 00:45:39.000 Yes, I think vitamin E and K both have that function of working at the cocutin site. 00:45:39.000 --> 00:45:44.000 So do you think it's necessary for someone to supplement with cocutin if they're using vitamin K? 00:45:44.000 --> 00:45:49.000 Well, I wouldn't mix them even in your stomach. 00:45:49.000 --> 00:45:58.000 I think it's good to take them at a different time because I've seen a reaction which, 00:45:58.000 --> 00:46:05.000 at least in the presence of light, I think it might cause other reactions to happen 00:46:05.000 --> 00:46:12.000 when the vitamin E reacts with vitamin K. 00:46:12.000 --> 00:46:15.000 Okay, we have another caller. So let's take this next caller. 00:46:15.000 --> 00:46:17.000 You're on the air. Where are you from? 00:46:17.000 --> 00:46:21.000 Hi, this is Sue. I'm in Albion. 00:46:21.000 --> 00:46:23.000 Albion, okay. Hi, what's your question? 00:46:23.000 --> 00:46:28.000 I got some thyroid levels drawn because I do have Hashimoto's. 00:46:28.000 --> 00:46:36.000 It inflamed quite a bit, and I just wanted to read them out and see 00:46:36.000 --> 00:46:45.000 if there's a T3 level, T4, TSH. TSH was 0.48. 00:46:45.000 --> 00:46:54.000 Free T4, 0.97. And the T3 was 110 nanograms per deciliter. 00:46:54.000 --> 00:47:03.000 And the endocrinologist was saying to increase a thyroid medication 00:47:03.000 --> 00:47:08.000 to kind of make that thyroid go to sleep so that the inflammation would go down. 00:47:08.000 --> 00:47:15.000 And I wanted to get Dr. Peat's thoughts, and I'd like to hang up unless he has a question for me. 00:47:15.000 --> 00:47:17.000 Sure. Dr. Peat? 00:47:17.000 --> 00:47:23.000 Yeah, keeping the TSH, that's probably a safe level, 00:47:23.000 --> 00:47:33.000 but I know lots of people who keep it at 0.01 and less and feel fine. 00:47:33.000 --> 00:47:40.000 But the TSH is a promoter of inflammation, not only in the thyroid gland, 00:47:40.000 --> 00:47:47.000 but in blood vessels, bone marrow, every place it's been studied, it promotes inflammation. 00:47:47.000 --> 00:47:58.000 And it happens to be activated by the stress, oxygen-deprived condition of the cells. 00:47:58.000 --> 00:48:08.000 So it's one of the mediators of the oxygen-deficient stress condition, 00:48:08.000 --> 00:48:15.000 along with estrogen, prostaglandins, cortisol, and nitric oxide. 00:48:15.000 --> 00:48:20.000 TSH itself is an inflammation promoter. 00:48:20.000 --> 00:48:29.000 So if you govern your dose by things like heart rate, temperature, 00:48:29.000 --> 00:48:35.000 and especially your middle of the day temperature and resting heart rate, 00:48:35.000 --> 00:48:42.000 and your appetite and thirst and quality of sleep, 00:48:42.000 --> 00:48:54.000 a doctor can do the Achilles reflex relaxation test to find out how your nerves and muscles are acting. 00:48:54.000 --> 00:49:02.000 People have different sensitivities to the T3 and T4, 00:49:02.000 --> 00:49:15.000 and the tissue-specific effect of either of those is affected by how inflamed you are generally. 00:49:15.000 --> 00:49:21.000 So if you have a lot of polyunsaturated fat and prostaglandins circulating, 00:49:21.000 --> 00:49:29.000 then a given amount of T3 isn't going to have the same local effect on any of your tissues. 00:49:29.000 --> 00:49:41.000 So really this persistence of an inflamed thyroid where I'm feeling like I'm being strangled 00:49:41.000 --> 00:49:46.000 may have more to do with my generalized inflammatory response. 00:49:46.000 --> 00:49:48.000 Yeah, I think so. 00:49:48.000 --> 00:49:51.000 Okay, thank you so much. Bye-bye. 00:49:51.000 --> 00:49:57.000 Also, when you're low thyroid, you produce a lot of antibodies to lots of things, 00:49:57.000 --> 00:50:00.000 and you can also produce antibodies to your own thyroid. 00:50:00.000 --> 00:50:05.000 So part of the low thyroid condition is producing extra antibodies. 00:50:05.000 --> 00:50:09.000 And those antibodies are part of a cleanup process. 00:50:09.000 --> 00:50:16.000 So when you stop the inflammation, the antibody production will stop, 00:50:16.000 --> 00:50:23.000 and then it will take several months for the circulating level of the antibodies to disappear. 00:50:23.000 --> 00:50:28.000 So basically to summarize, to try to keep your TSH as close to zero as possible, 00:50:28.000 --> 00:50:34.000 and the blood levels of free T3 and free T4 are not as indicative of a-- 00:50:34.000 --> 00:50:39.000 well, not a good measurement or not a good guideline to assess your thyroid function, 00:50:39.000 --> 00:50:44.000 all those things Dr. Feet mentioned, like your heart rate, your temperature, and your appetite. 00:50:44.000 --> 00:50:49.000 Those things are much more accurate at diagnosing yourself. 00:50:49.000 --> 00:51:01.000 And George Kreil at the Cleveland Clinic in the 1970s found that even for most types of thyroid cancer, 00:51:01.000 --> 00:51:09.000 if you keep your TSH near zero, it keeps down almost all of the recurrences of thyroid cancer. 00:51:09.000 --> 00:51:12.000 Okay, we have another caller, so let's take this next caller. 00:51:12.000 --> 00:51:14.000 Caller, where are you from? 00:51:14.000 --> 00:51:16.000 Miranda. 00:51:16.000 --> 00:51:17.000 Miranda, what's your question? 00:51:17.000 --> 00:51:21.000 Okay, it's regarding magnesium supplementation. 00:51:21.000 --> 00:51:27.000 I take a magnesium glycinate one in the morning, and I take one in the evening, 00:51:27.000 --> 00:51:32.000 and I find that it helps my nervous system in general. 00:51:32.000 --> 00:51:40.000 But my one complaint is that whenever I do it, whenever I start supplementing with magnesium, 00:51:40.000 --> 00:51:45.000 I find that my belly fat gets worse. 00:51:45.000 --> 00:51:53.000 And, I mean, people that see me with my clothes on would say I'm just this tall, gawky guy, 00:51:53.000 --> 00:51:58.000 but underneath my belly fat is very pronounced. 00:51:58.000 --> 00:52:03.000 And if I drop the magnesium, it doesn't seem to be quite as pronounced. 00:52:03.000 --> 00:52:14.000 But I had read from another source many years ago that magnesium chloride didn't stoke that problem, 00:52:14.000 --> 00:52:18.000 and that most others, especially magnesium oxide, would really provoke it. 00:52:18.000 --> 00:52:22.000 But I was just wondering if you have any thoughts on that. 00:52:22.000 --> 00:52:26.000 Dr. Peat, what do you think about magnesium glycinate as a substance that might be good? 00:52:26.000 --> 00:52:34.000 I've never used that one myself, but all of the forms that I've experimented with, 00:52:34.000 --> 00:52:45.000 and for quite a few other people, magnesium supplements can cause intestinal inflammation or irritation. 00:52:45.000 --> 00:52:56.000 And I would guess that that's happening with an increase of histamine, nitric oxide, and absorbing endotoxin and such. 00:52:56.000 --> 00:52:59.000 Yeah, so it's not actually an increase in belly fat and chlorine. 00:52:59.000 --> 00:53:09.000 It's probably more due to an increased bogginess or a water retention within the tissues that this magnesium may be causing 00:53:09.000 --> 00:53:14.000 that would then push your stomach further out and might make you feel like you'd actually increase more fat. 00:53:14.000 --> 00:53:15.000 Is that what you're suggesting, Dr. Peat? 00:53:15.000 --> 00:53:19.000 Are you suggesting that that increased inflammation could actually lay down more fat? 00:53:19.000 --> 00:53:29.000 Well, the fat would increase over a period of many months or years, but the water can increase overnight. 00:53:29.000 --> 00:53:34.000 Okay, well, I'm taking a prostate medication because I have an enlarged prostate, 00:53:34.000 --> 00:53:43.000 but PSA had no indication that it was out of an abnormal range. 00:53:43.000 --> 00:53:46.000 So I am playing with my water a bit. 00:53:46.000 --> 00:53:54.000 I have to go to the bathroom quite a bit because I'm taking this herbal from New Chapter for the prostate. 00:53:54.000 --> 00:53:57.000 Okay, so you're finding benefit from it? 00:53:57.000 --> 00:54:02.000 That's probably based on pumpkin seed extract and saw palmetto. 00:54:02.000 --> 00:54:05.000 Right, right, yes, it does have those for sure. 00:54:05.000 --> 00:54:07.000 I don't know. 00:54:07.000 --> 00:54:17.000 You know, it's almost from not passing enough urine to passing too much, getting up too many times during the night. 00:54:17.000 --> 00:54:24.000 But it feels healthier than insufficient urine flow. 00:54:24.000 --> 00:54:28.000 Dr. Peat, a quick -- we've only got a few minutes left here at the end of the show, 00:54:28.000 --> 00:54:34.000 but a quick word on prostatic hypertrophy, benign prostatic hypertrophy, 00:54:34.000 --> 00:54:38.000 and urination difficulties and what your approach to that would be? 00:54:38.000 --> 00:54:49.000 Well, the thyroid is the basic thing because it helps you make the anti-inflammatory pro-oxygen steroids, 00:54:49.000 --> 00:54:56.000 pregnenolone, progesterone, DHEA, and testosterone, and keeps down the estrogen. 00:54:56.000 --> 00:55:09.000 When anything is irritating your intestine, increasing histamine and other anti-oxidative mediators, 00:55:09.000 --> 00:55:17.000 the inflammation spreads from your intestine through your whole pelvis in particular, 00:55:17.000 --> 00:55:27.000 and it will cause the smooth muscle of the bladder wall to become hyperactive and oversensitive, 00:55:27.000 --> 00:55:30.000 and that causes frequent urination. 00:55:30.000 --> 00:55:36.000 And lots of people assume that there's something wrong with their prostate 00:55:36.000 --> 00:55:43.000 when it's really the intestine inflaming the whole urinary system. 00:55:43.000 --> 00:55:50.000 I see. And so, as you were saying, if the magnesium is inflaming the irritation, 00:55:50.000 --> 00:55:55.000 then the magnesium might be possibly indicated? 00:55:55.000 --> 00:55:59.000 I think so. You can get adequate magnesium. 00:55:59.000 --> 00:56:03.000 If your thyroid lets your cells retain magnesium, 00:56:03.000 --> 00:56:17.000 then 400 milligrams per day is easy to get from foods, fruit, fruit juice, milk, cheese, eggs, meat, seafood. 00:56:17.000 --> 00:56:22.000 All of those things are very good sources of magnesium. Coffee? 00:56:22.000 --> 00:56:29.000 Yeah, unfortunately, a lot of those are-- I'm definitely a committed vegetarian, so I don't have eggs. 00:56:29.000 --> 00:56:34.000 Okay, I don't want to butt in there, but let's put it like this. It's three minutes to eight o'clock, 00:56:34.000 --> 00:56:36.000 and we're going to wrap up with the show here. 00:56:36.000 --> 00:56:39.000 So thank you very much for your call, caller, and all the calls we received. 00:56:39.000 --> 00:56:41.000 Yeah, thank you very much. 00:56:41.000 --> 00:56:43.000 And I just want to say one more thing about magnesium and thyroid. 00:56:43.000 --> 00:56:49.000 Dr. Peat, you've said that when you have a thyroid deficiency, you're not able to store magnesium properly, 00:56:49.000 --> 00:56:53.000 and so it almost is like you have a magnesium deficiency as well. 00:56:53.000 --> 00:57:02.000 Yeah, and you can correct a magnesium deficiency if you go at your thyroid dosing carefully. 00:57:02.000 --> 00:57:07.000 Over a few days, it helps you extract it from your ordinary diet. 00:57:07.000 --> 00:57:10.000 Right, so you don't need to supplement such large doses. 00:57:10.000 --> 00:57:15.000 Yeah, in the first two or three days, if you're going to start a thyroid supplement, 00:57:15.000 --> 00:57:19.000 sometimes magnesium helps you adapt more quickly to the thyroid. 00:57:19.000 --> 00:57:26.000 But usually, for a vegetarian, you can boil any kind of green leaves. 00:57:26.000 --> 00:57:31.000 It doesn't matter what kind, but the magnesium comes out very quickly when you boil it. 00:57:31.000 --> 00:57:33.000 Just make sure to drink the water you boiled in. 00:57:33.000 --> 00:57:34.000 Yeah. 00:57:34.000 --> 00:57:36.000 Okay, well, thank you so much for your time. 00:57:36.000 --> 00:57:39.000 I don't want to cut you off, Dr. Peat. I just want to make sure people know how to reach you. 00:57:39.000 --> 00:57:43.000 So once again, thanks so much for giving your time. 00:57:43.000 --> 00:57:46.000 You were so very generous, and we really do appreciate it. 00:57:46.000 --> 00:57:54.000 For those people who have heard Dr. Peat or want to find out more about him, www.rayPeat.com. 00:57:54.000 --> 00:57:59.000 Lots of articles, scientifically referenced. He really does know what he's talking about. 00:57:59.000 --> 00:58:05.000 For those of you who've listened to the show, we can also be reached toll-free on 1-888-WBMERB, 00:58:05.000 --> 00:58:08.000 Monday through Friday, for consultations or further information. 00:58:08.000 --> 00:58:09.000 My name's Andrew Murray. 00:58:09.000 --> 00:58:12.000 My name's Sarah Johanneson Murray. Thank you for tuning in tonight. 00:58:12.000 --> 00:58:13.000 We've enjoyed your calls. 00:58:13.000 --> 00:58:14.000 Good night. 00:58:14.000 --> 00:58:15.000 time.