WEBVTT 00:00:00.000 --> 00:00:06.280 Well welcome to this month's Ask Your Ob Doctor. My name is Andrew Murray. From 7 till 8pm 00:00:06.280 --> 00:00:12.280 this is a live show. We have callers calling in from 7.30 to 8pm to ask questions about 00:00:12.280 --> 00:00:16.860 the topic that we are going to go through. This month's topic is going to be a round 00:00:16.860 --> 00:00:25.280 up of the point that we left off in March discussing progesterone and estrogen. And 00:00:25.280 --> 00:00:31.840 this month I want to dissect that a little more with some of the facts and some of the 00:00:31.840 --> 00:00:39.240 arguments against and in fact plain refuting of those "facts" about how positive estrogen 00:00:39.240 --> 00:00:46.920 was and how negative progesterone was in a paper that was written by Inger Sundström 00:00:46.920 --> 00:00:52.120 Promona at the University of Uppsala in Sweden, apparently one of the leading experts on brain 00:00:52.120 --> 00:01:00.560 metabolism and sex hormones. I mentioned in March that the PROTECT and SYNAPSE which are 00:01:00.560 --> 00:01:06.720 acronyms, PROTECT and SYNAPSE trials of progesterone's anti-inflammatory effects used in the treatment 00:01:06.720 --> 00:01:14.000 of traumatic brain injury were published and reviewed and apparently were relatively unsuccessful. 00:01:14.000 --> 00:01:23.520 Now Dr. Stein, a 30 year PhD brain injury expert at Emory University was part of the 00:01:23.520 --> 00:01:29.480 team which published the paper in the Journal of Neurotrauma and he outlined some very obvious 00:01:29.480 --> 00:01:36.420 mistakes in the studies and basically said that the criteria with which the study was 00:01:36.420 --> 00:01:43.400 done did not produce valid results and he was strongly opposed to the findings which 00:01:43.400 --> 00:01:50.440 showed there was no positive benefit for progesterone citing some very good facts and evidence to 00:01:50.440 --> 00:02:00.620 the contrary. So in terms of the ongoing lies if you like about how positive estrogen is 00:02:00.620 --> 00:02:07.520 for you and/or how dangerous progesterone is for you, we have had for many years now 00:02:07.520 --> 00:02:14.320 Dr. Raymond Peat joining us to discuss his findings and cover a lot of evidence that 00:02:14.320 --> 00:02:20.240 he has unearthed himself and I am very pleased to have him on the show. So I wanted just 00:02:20.240 --> 00:02:24.840 to quickly welcome Dr. Peat and then give people a little more information about how 00:02:24.840 --> 00:02:30.720 to contact the studio for call-ins from 7.30 on. So Dr. Peat are you with us? Yes I am 00:02:30.720 --> 00:02:36.120 here. Ok thanks so much for joining us. For people that are in the area there is a 707 00:02:36.120 --> 00:02:43.720 number which is 707 923 3911 and I wanted to quickly ask, I just noticed as I came into 00:02:43.720 --> 00:02:48.960 the studio that the 800 numbers have been scratched out. I was just about to correct 00:02:48.960 --> 00:02:52.320 you in case you started saying that. Yeah apparently there is a problem with the 800 00:02:52.320 --> 00:02:58.480 numbers so anybody can call from anywhere. The country code is 01 I believe. Yeah because 00:02:58.480 --> 00:03:04.360 we have people from Finland, we have people from Australia and other places in the world. 00:03:04.360 --> 00:03:15.520 So ok yeah 707 923 3911. So I also wanted just to point out that after business hours 00:03:15.520 --> 00:03:21.440 or during business hours rather 9 to 5 Monday through Friday people can either call in and 00:03:21.440 --> 00:03:30.960 either or write to me at my address Andrew@westernbotanicalmedicine.com or call if they have any questions or if 00:03:30.960 --> 00:03:37.120 they want to follow up any consultations, nutritional consultations or related subjects 00:03:37.120 --> 00:03:41.760 around health and the things that we are purporting to be things that are very beneficial for 00:03:41.760 --> 00:03:47.200 you which you won't normally hear in the mainstream. Dr. Peat has been a big advocate of things 00:03:47.200 --> 00:03:52.720 like thyroid and sugar and progesterone and the mainstream medicine and science would 00:03:52.720 --> 00:03:58.760 argue that sugar is not good for you or that pregnenolone or progesterone for example are 00:03:58.760 --> 00:04:03.920 not good for you when there is plenty of evidence to show that there is. I think this is probably 00:04:03.920 --> 00:04:10.880 never so clear as in the trials of HRT and some of the withdrawing of those HRT programs 00:04:10.880 --> 00:04:18.920 and hormone replacement therapy up quote unquote that women with estrogen dominance is probably 00:04:18.920 --> 00:04:23.040 the last thing that they want is estrogen replacement but yet the industry and doctors 00:04:23.040 --> 00:04:31.680 still continue to say that the bone health benefits of estrogen are to be advised and 00:04:31.680 --> 00:04:37.480 that women with hot flashes and other mood disorders that estrogen is a lacking substance 00:04:37.480 --> 00:04:42.240 that they actually need and will help them. So during the course of the next hour and 00:04:42.240 --> 00:04:48.720 30 minutes or so I am going to be discussing some of the arguments for progesterone and 00:04:48.720 --> 00:04:54.880 the arguments against estrogen and Dr. Peat with his background is probably never so qualified 00:04:54.880 --> 00:05:00.600 to speak on the subject given that his PhD was in reproductive hormones. So Dr. Peat 00:05:00.600 --> 00:05:04.640 would you just give an outline of your professional and academic background so people that are 00:05:04.640 --> 00:05:12.880 listening can hear where you have come from? Before I studied biology I was a literature, 00:05:12.880 --> 00:05:25.720 linguistics and art major and teacher and I decided to study biology initially to get 00:05:25.720 --> 00:05:33.400 more understanding of how language and intelligence and consciousness work and what I found was 00:05:33.400 --> 00:05:42.200 that brain biology, cognitive science so called was pure dogmatism, very little science in 00:05:42.200 --> 00:05:50.040 it so I shifted over to reproductive physiology to basically study how the organism works 00:05:50.040 --> 00:05:59.120 all the way from the germ cell to the brain and the brain science really is not distinct 00:05:59.120 --> 00:06:11.520 from reproductive physiology. The brain is really the motor for the whole life process 00:06:11.520 --> 00:06:26.640 and I did my dissertation in 1972 on the oxidative changes in the uterus in particular as it 00:06:26.640 --> 00:06:32.280 changes with aging. Okay good so I guess let's just jump straight 00:06:32.280 --> 00:06:40.120 into some of the questions that I had that we got left off from March and these are basic 00:06:40.120 --> 00:06:47.000 inquiries into the mechanism by which estrogen has its negative effects and then we'll get 00:06:47.000 --> 00:06:54.400 into an article that was written by Inger Sundström who is a professor at the University 00:06:54.400 --> 00:06:59.600 of Uppsala and an apparent leading expert on brain metabolism and sex hormones who said 00:06:59.600 --> 00:07:07.160 some very strange things that I'd like you just to hear and give your take on it. 00:07:07.160 --> 00:07:14.120 Susceptible epilepsy and the estrogens like estrone, estriol and estradiol how do you 00:07:14.120 --> 00:07:19.800 understand the triggering of the epilepsy in these certain susceptible females? It's 00:07:19.800 --> 00:07:25.240 estrogen related isn't it? Yeah in my research I looked through everything 00:07:25.240 --> 00:07:32.960 that had been done on physiology especially as it relates to the brain and uterus up until 00:07:32.960 --> 00:07:43.080 1970 and I couldn't find any evidence that would clearly distinguish the physiology of 00:07:43.080 --> 00:07:53.400 estrogen stimulation from x-ray stimulation or oxygen deprivation or vitamin E deficiency 00:07:53.400 --> 00:08:02.080 which interferes with oxygen use. All of those things deplete the energy production of the 00:08:02.080 --> 00:08:15.160 cell which is based on oxidation and when the brain is oversupplied with estrogen or 00:08:15.160 --> 00:08:23.080 lacks its antagonist especially progesterone the whole system but everything in the brain 00:08:23.080 --> 00:08:32.800 included wastes oxygen and is unable to keep the energy level up to the point that the 00:08:32.800 --> 00:08:43.400 cells are stable and one of the strange things that has been overlooked or seen upside down 00:08:43.400 --> 00:08:52.240 in both biology and medicine for most of the century is that high energy state of a cell 00:08:52.240 --> 00:09:00.680 is the state in which it's ready to work and function but it is not acting all the time 00:09:00.680 --> 00:09:08.920 it's sitting there ready to work and when it is forced to work more than it is ready 00:09:08.920 --> 00:09:19.520 for the energy level falls and it gets into a state trying to restore the energy but it 00:09:19.520 --> 00:09:30.960 is in a constantly active state. If you cause hypoglycemia by interfering with the liver 00:09:30.960 --> 00:09:40.120 for example it works the same as a lack of oxygen and estrogen happens to interfere with 00:09:40.120 --> 00:09:47.640 the supply of glucose to cells. It activates insulin but it also activates the release 00:09:47.640 --> 00:09:56.480 of fatty acids from the tissues and the fatty acids block the ability to oxidize glucose 00:09:56.480 --> 00:10:07.480 so estrogen does. It activates the cells by increasing the function of glutamic acid, 00:10:07.480 --> 00:10:20.600 a brain excitant and in increasing glutamate it decreases GABA the inhibiting signal. GABA 00:10:20.600 --> 00:10:31.240 should be produced by the breakdown of glutamic acid so estrogen is exciting the brain cells 00:10:31.240 --> 00:10:38.240 and at the same time interfering with their use of oxygen and glucose. 00:10:38.240 --> 00:10:45.120 Estrogen and the estrogens, estro and estrolysis, etc. these really mimic a kind of stress response 00:10:45.120 --> 00:10:46.120 then? 00:10:46.120 --> 00:10:56.560 Yes, I consider estrogen's function to be the controlled stress. The whole organism 00:10:56.560 --> 00:11:08.280 is moving through a developmental process and it requires a constant supply of energy 00:11:08.280 --> 00:11:18.040 and if that energy supply becomes fatally impaired then the function of estrogen in 00:11:18.040 --> 00:11:29.040 the reproductive system is to erase the whole scheme that was producing the organism's 00:11:29.040 --> 00:11:37.280 development through its life process. Suddenly the excess of estrogen as a stress signal 00:11:37.280 --> 00:11:52.080 erases the whole program and reverts to the single multiplying cell. So without anything 00:11:52.080 --> 00:12:01.680 interfering estrogen tends to produce the cancer cell but it also activates the production 00:12:01.680 --> 00:12:09.920 of the egg and the readiness of the egg to start a new organism. So its proper function 00:12:09.920 --> 00:12:20.560 should be once a month for a few hours to activate the potential new life and that only 00:12:20.560 --> 00:12:34.520 starts at puberty. Up until puberty the brain is metabolizing at a very high rate and the 00:12:34.520 --> 00:12:43.120 catamenial epilepsy tends to begin around the age of nine when estrogen is rising and 00:12:43.120 --> 00:12:54.120 progesterone hasn't risen yet. The brain metabolism slows down at puberty so the body 00:12:54.120 --> 00:13:01.440 takes it as a threat to survival and so it turns on the reproductive process. 00:13:01.440 --> 00:13:06.320 I just wanted to kind of recount that you said that and I think I've understood this 00:13:06.320 --> 00:13:12.200 in the correct way that estrogen, the only real benefit for estrogen then is the inflammation 00:13:12.200 --> 00:13:18.120 it provides or promotes to stimulate implantation of a new site in the endometrium in terms 00:13:18.120 --> 00:13:23.120 of successful pregnancies. Is that correct? And then outside of that it doesn't really 00:13:23.120 --> 00:13:29.960 have too much benefit. Yeah, throughout the organism whenever the 00:13:29.960 --> 00:13:36.600 tissue is stressed it tends to turn on locally the production of estrogen. That's how it 00:13:36.600 --> 00:13:44.040 so easily leads to cancer because every tissue has the apparatus for making estrogen. 00:13:44.040 --> 00:13:47.400 Right, you said every cell in the body can secrete it essentially. 00:13:47.400 --> 00:13:54.440 Yeah, and after menopause when the production of progesterone becomes very limited there 00:13:54.440 --> 00:14:00.840 is a tendency for all of the body's tissues to begin making estrogen. So it's just the 00:14:00.840 --> 00:14:09.600 opposite of what the menopause doctors have been teaching. When progesterone disappears 00:14:09.600 --> 00:14:16.760 the breast, the uterus, the brain, the liver, the skin, the fat, muscles even begin producing 00:14:16.760 --> 00:14:24.320 estrogen, but it can't escape from the cell because it also increases the estrogen binding 00:14:24.320 --> 00:14:34.480 protein, the estrogen so-called receptor. And in the absence of progesterone the intracellular 00:14:34.480 --> 00:14:40.560 estrogen increases but it doesn't get into the blood so you measure the blood and it 00:14:40.560 --> 00:14:44.440 looks like you're estrogen deficient. Interesting, it doesn't get into the blood, 00:14:44.440 --> 00:14:47.040 huh? Yeah, exactly when you're being systemically 00:14:47.040 --> 00:14:51.560 poisoned with intracellular estrogen. And as you've mentioned before on previous 00:14:51.560 --> 00:14:58.200 shows estrogen is very responsible for edema, cell swelling and that inefficiency that comes 00:14:58.200 --> 00:15:01.400 with that water logging from an energy point of view. 00:15:01.400 --> 00:15:08.920 The individual cell swells up when it's being excited and de-energized. When you can get 00:15:08.920 --> 00:15:16.480 the energy back up that squeezes the water out and that same swollen state occurs in 00:15:16.480 --> 00:15:24.000 capillaries and blood vessels and even though they get thicker they become leaky. Water 00:15:24.000 --> 00:15:30.480 goes through them into the tissues and out of your bloodstream and that's involved in 00:15:30.480 --> 00:15:38.000 the circulatory problems of pregnancy. The blood volume can't be maintained while the 00:15:38.000 --> 00:15:44.160 legs and feet tend to swell up and the kidneys sense the lack of circulation because the 00:15:44.160 --> 00:15:50.000 blood volume has shrunk and so the kidneys send out signals to raise the blood pressure 00:15:50.000 --> 00:15:58.200 to try to get more circulation. Interesting, and then lastly just wanted to 00:15:58.200 --> 00:16:04.560 recap what you said about that depolarized and repolarized state of the cell. So you 00:16:04.560 --> 00:16:12.480 mentioned that when a cell is in a ready state to perform work that relaxed state is what 00:16:12.480 --> 00:16:18.320 is so important for that proper contraction, that proper action potential to occur to do 00:16:18.320 --> 00:16:25.840 work and that in hypothyroidism the cell remains in a constantly stressed state where it's 00:16:25.840 --> 00:16:31.280 not able to relax and it's that very lack of relaxation that causes the energy problems. 00:16:31.280 --> 00:16:37.200 You can see exactly the same process in the heart muscle as in the brain and other cells 00:16:37.200 --> 00:16:44.760 but it's very easy to study in the brain and in the muscle because the muscle is such a 00:16:44.760 --> 00:16:55.760 concentrated muscle system and estrogen weakens but makes more frequent the contraction and 00:16:55.760 --> 00:17:05.040 it's a great excess of estrogen causes a shock like state of the heart, rapid but very, very 00:17:05.040 --> 00:17:13.920 weak pulsation where progesterone strengthens, it lets the cells build up energy so that 00:17:13.920 --> 00:17:19.400 when it does contract it's a very powerful contraction and pumps very efficiently. 00:17:19.400 --> 00:17:24.480 Okay, good. Well I never like to turn people away and I know you do this because you like 00:17:24.480 --> 00:17:30.840 the interaction with people asking questions that you've no preparation for if you like, 00:17:30.840 --> 00:17:35.160 you've not been prepared so there's a caller on the line who I think wants to ask a question 00:17:35.160 --> 00:17:38.760 so let's take this caller, a call away from and what's your question? 00:17:38.760 --> 00:17:44.440 Yes, hi my name is Shana from Hesperia. Hey Hannah, welcome to the show. What's your 00:17:44.440 --> 00:17:49.360 question? Yes, my question is regarding chronic fatigue 00:17:49.360 --> 00:17:58.840 syndrome. Can Dr. Ray Peat elaborate on what this is and what is the underlying condition 00:17:58.840 --> 00:18:06.960 is it hypometabolism or what and then my second question is low dose naltrexone, is it effective 00:18:06.960 --> 00:18:10.280 for CFS? Okay, I think there's a lot of break up on 00:18:10.280 --> 00:18:14.040 the line but I think that first question was related to chronic fatigue syndrome, what 00:18:14.040 --> 00:18:19.360 do you see, your ideas on chronic fatigue syndrome, how do you see it and then also 00:18:19.360 --> 00:18:23.040 naltrexone I think was... Low dose. 00:18:23.040 --> 00:18:28.400 Low dose naltrexone, LDN. Okay, Dr. Peat, what do you think of chronic fatigue syndrome 00:18:28.400 --> 00:18:33.200 as a... One way of thinking of it is that it's very 00:18:33.200 --> 00:18:40.640 similar to in the brain the seizure state or in the heart the failure state under the 00:18:40.640 --> 00:18:50.840 influence of a lack of progesterone and excess of estrogen or simply such a deficiency of 00:18:50.840 --> 00:18:59.640 energy that the cell goes into that swollen over excitable state. When a cell is in very 00:18:59.640 --> 00:19:10.040 bad condition, as far as I know every cell in the body can also produce histamine as 00:19:10.040 --> 00:19:17.200 it's getting very desperate, not only in a chronic sort of desperation cells produce 00:19:17.200 --> 00:19:25.120 estrogen but in a most acute situation they produce histamine and in the hypothyroid, 00:19:25.120 --> 00:19:33.680 low progesterone chronic state the body tends to locally produce a lot of histamine and 00:19:33.680 --> 00:19:38.760 other inflammatory things. Okay, and what do you think about naltrexone, 00:19:38.760 --> 00:19:47.160 low dose naltrexone, does that have any merit? In my experience using naloxone more than 00:19:47.160 --> 00:19:54.280 naltrexone but they're essentially identical, one is a little more oil soluble, I found 00:19:54.280 --> 00:20:06.520 that from one to four milligrams per day of naloxone would break a depressed condition 00:20:06.520 --> 00:20:17.120 by suppressing the endorphins which are induced by lactic acid and fatigue. The endorphins 00:20:17.120 --> 00:20:27.680 are another emergency measure to turn off the excitation but with a very small dose 00:20:27.680 --> 00:20:36.360 some people use even a hundredth of a milligram and find a very therapeutic effect so I consider 00:20:36.360 --> 00:20:44.920 four milligrams a day a fairly big, larger than necessary dose. 00:20:44.920 --> 00:20:48.880 Okay good, so let me just quickly ask, I think we have another caller on the line, okay well 00:20:48.880 --> 00:20:52.080 let's take this next caller and see where we're going, caller you're on the end, what's 00:20:52.080 --> 00:21:00.160 your question? Hi, I have a question about the B complex vitamins, I've been listening 00:21:00.160 --> 00:21:07.240 for a while so I understand B1, B2 and B3 and why they're beneficial, I wanted to go 00:21:07.240 --> 00:21:14.360 backwards so B9 is I guess folic acid and B7 is biotin and I think in some of the stuff 00:21:14.360 --> 00:21:21.280 I read about what people seem to be interpreting regarding your research or point of view is 00:21:21.280 --> 00:21:34.880 that 1, 2 and 3 are important and 6 in a smaller amount but B5, anaphenic acid, B4, adenosine 00:21:34.880 --> 00:21:42.360 and folic acid and B12 are probably not to be taken and so I'm probably not giving the 00:21:42.360 --> 00:21:45.600 full story so I just wanted to say that's sort of the question, are these the bad guys 00:21:45.600 --> 00:21:52.040 and if so why? Because when someone gets a B complex vitamin they actually have specific 00:21:52.040 --> 00:21:59.280 ratios of all these in many cases and I'm just wondering are they properly named B vitamins 00:21:59.280 --> 00:22:05.720 and or should they be taken and thought of separately as opposed to particular ratios 00:22:05.720 --> 00:22:10.920 between each one of them to have the proper effect systemically? Dr. Peat I know you're an 00:22:10.920 --> 00:22:18.320 advocate of liver for that reason but how would you define the B vitamins in terms of 00:22:18.320 --> 00:22:28.720 necessity and the sources of? Their main metabolic similarity is that they are regulators and 00:22:28.720 --> 00:22:40.160 facilitators of cell oxidative energy processes. Panthenic acid is somewhat off the main group 00:22:40.160 --> 00:22:54.640 but it's very essential. It's anti-stress, helps with regulating blood sugar and allergies. 00:22:54.640 --> 00:23:04.440 Sometimes 400 to 500 mg dose of panthenic acid can relieve stress symptoms and it's 00:23:04.440 --> 00:23:12.240 unusual in that it doesn't affect the interactions of the others. It's sort of on a side line 00:23:12.240 --> 00:23:20.360 where it can be taken in monkeys, they fed them a cup a day of pure panthenic acid with 00:23:20.360 --> 00:23:26.560 no side effects. If you did that with any of the other B vitamins you would quickly 00:23:26.560 --> 00:23:36.360 reach a toxic effect. Panthenic acid can be taken daily because all these are water soluble 00:23:36.360 --> 00:23:42.280 but this can be taken daily up to 400 mg and you will see some benefit of cellular oxidative 00:23:42.280 --> 00:23:48.000 energy. I'm thinking more about digestion too because some of these, like I've taken 00:23:48.000 --> 00:23:56.320 B1 and B2 recently and I really believe it's helped my ability to digest things. I'm a 00:23:56.320 --> 00:24:03.280 young man of around 60 so I'm just wondering how to take these, how much to take and how 00:24:03.280 --> 00:24:10.080 often as opposed to what's being out there in the research because it seems to not be 00:24:10.080 --> 00:24:17.280 accurate relative to what you're saying. The orthomolecular movement 40 years ago I think 00:24:17.280 --> 00:24:25.400 encouraged a lot of overdose excess use of them. You can get extremely therapeutic results 00:24:25.400 --> 00:24:36.520 sometimes with 5 or 10 times the minimum daily requirement like 10 or 20 mg of B1, 10 mg 00:24:36.520 --> 00:24:51.040 of B2, 10 mg of B6 and so on. Sometimes larger doses are effective but I think it's good 00:24:51.040 --> 00:24:55.480 to try the smallest dose, maybe 5 times the minimum daily requirement. 00:24:55.480 --> 00:25:01.280 Okay, so it's okay to take that daily. So for the ones you mentioned, about 10 to 20 00:25:01.280 --> 00:25:08.040 mg in a day is okay and I guess B3 is a little different in the sense you could take 400 00:25:08.040 --> 00:25:15.120 to 500 of that one too, right? It's not just B5 but B3 also, am I right? 00:25:15.120 --> 00:25:16.120 Niacin. 00:25:16.120 --> 00:25:17.120 Niacinamide. 00:25:17.120 --> 00:25:28.160 Yeah, it's important to get the amide form. The other releases, inflammatory mediators 00:25:28.160 --> 00:25:36.440 and the niacinamide is safe up to at least a couple hundred milligrams but I think I've 00:25:36.440 --> 00:25:43.840 seen people with brain, terminal brain diseases cure themselves taking just 150 or 200 of 00:25:43.840 --> 00:25:45.920 niacinamide per day. 00:25:45.920 --> 00:25:56.640 Okay, so and B7 is biotin. I hear people say that that will reduce your blood, your glucose 00:25:56.640 --> 00:26:01.120 levels but then I read and I say, "Well gee, maybe that's not true. Maybe it actually regulates 00:26:01.120 --> 00:26:12.760 them dynamically." So what about biotin? Is there any negatives to taking biotin in 00:26:12.760 --> 00:26:16.760 like 5 to 10,000? I think it's micrograms, not milligrams. 00:26:16.760 --> 00:26:23.760 I've seen the good results from very, very big doses of biotin but 50 years ago, some 00:26:23.760 --> 00:26:31.320 animal studies showed that a moderate overdose could cause liver cancer. So I've always been 00:26:31.320 --> 00:26:36.320 leery about it but I've never seen people repeating those experiments. 00:26:36.320 --> 00:26:42.480 What's a dose? I mean what, so is 5,000 an excessive dose, micrograms or are you talking 00:26:42.480 --> 00:26:43.480 about something like... 00:26:43.480 --> 00:26:47.240 I would stick to around one milligram of biotin. 00:26:47.240 --> 00:26:54.240 Okay, one milligram. Okay, gotcha. Okay, and then folic acid, you're kind of, I mean I've 00:26:54.240 --> 00:27:00.600 read that you somehow think that's like somehow dangerous to take at all. I could be wrong 00:27:00.600 --> 00:27:02.000 too but that's what I've read. 00:27:02.000 --> 00:27:09.200 I think it's safe for the dose of around one milligram, maybe as high as five milligrams 00:27:09.200 --> 00:27:18.040 per day but you have to be cautious with especially vitamin B2 and folic acid because something 00:27:18.040 --> 00:27:25.480 in the synthetic process makes a lot of people get migraine headaches and hemorrhoids and 00:27:25.480 --> 00:27:33.720 other very intense symptoms from those which happen to be yellow molecules and I think 00:27:33.720 --> 00:27:42.440 it's something about their sensitivity to light and oxidation that makes the pure chemical 00:27:42.440 --> 00:27:44.600 pretty allergenic for a lot of people. 00:27:44.600 --> 00:27:48.720 So could it give you a rash too or something like that or just a headache? 00:27:48.720 --> 00:27:52.440 I didn't hear that. 00:27:52.440 --> 00:27:55.800 Could it give you a rash or just a headache? 00:27:55.800 --> 00:28:03.600 The worst symptoms I've heard about are migraine-like headaches and bowel problems but that could 00:28:03.600 --> 00:28:08.120 be the bowel inflammation can lead to rashes. 00:28:08.120 --> 00:28:14.560 Okay that makes sense and then B12, I really almost see almost no writing on that or just 00:28:14.560 --> 00:28:18.480 curious because a lot of people say you've got to have your B12 up and I know that gets 00:28:18.480 --> 00:28:25.200 to methylation but is there an amount or is it the amount that you consume in your basic 00:28:25.200 --> 00:28:26.800 diet should be more than enough? 00:28:26.800 --> 00:28:34.520 Yeah, if you eat animal products in particular and the intestine bacteria can make a lot 00:28:34.520 --> 00:28:35.520 of it. 00:28:35.520 --> 00:28:44.120 I hear from a lot of people with small intestine inflammation who have about 50% higher than 00:28:44.120 --> 00:28:50.760 the upper normal range for B12 apparently because their bacteria are thriving where 00:28:50.760 --> 00:28:52.160 they shouldn't be. 00:28:52.160 --> 00:28:57.920 Alright, I appreciate your questions, Cora and I've got to get on with the questions 00:28:57.920 --> 00:29:03.040 that I've got for Dr. Peat surrounding last month's March's radio show so we can get into 00:29:03.040 --> 00:29:04.280 some fresh topic. 00:29:04.280 --> 00:29:11.920 Dr. Peat, I wanted to go over the article just briefly that was written by this professor 00:29:11.920 --> 00:29:16.000 at the University of Uppsala in Sweden who is an expert on brain metabolism and sex hormones 00:29:16.000 --> 00:29:22.280 just to illustrate to people how wrong things can get from the quote unquote academic professionals 00:29:22.280 --> 00:29:29.760 and just to see how this was twisted in terms of what I'm about to speak verbatim from the 00:29:29.760 --> 00:29:35.720 article and I just want to stop you at different points during this just to hear your side 00:29:35.720 --> 00:29:39.560 of it so that you can point people in the right direction because people are going to 00:29:39.560 --> 00:29:44.520 read these things on ResearchGate or PubMed or other places and just take it as the truth 00:29:44.520 --> 00:29:49.840 because it's written by a university professor who specializes in this kind of thing but 00:29:49.840 --> 00:29:54.200 just want to bring the truth home again wherever possible. 00:29:54.200 --> 00:30:02.160 So an article was written about pregnenolone and progesterone and saying that basically 00:30:02.160 --> 00:30:08.920 the negative associations with it were fairly rife and so just going through what she had 00:30:08.920 --> 00:30:15.160 written, she talked about PMS and saying that for some people it was unpredictable and for 00:30:15.160 --> 00:30:19.760 many it was hard to explain but feelings of worry associated with the menstrual cycle 00:30:19.760 --> 00:30:25.200 had very specific cause and that this was the same hormone used in much birth control 00:30:25.200 --> 00:30:30.360 and that 85% of women experience premenstrual stress or PMS in the days leading up to the 00:30:30.360 --> 00:30:36.600 period and according to the American Congress of Obstetricians and Gynecologists as well 00:30:36.600 --> 00:30:41.520 this condition comes with physical symptoms like painful joints or breasts, headaches, 00:30:41.520 --> 00:30:46.800 sleeplessness etc and I'm sure most women can identify with these symptoms and she says 00:30:46.800 --> 00:30:52.080 it's pretty much down to one hormone progesterone and she's the leading expert on brain metabolism 00:30:52.080 --> 00:30:57.000 and sex hormone so she goes on to mention that progesterone appears after ovulation 00:30:57.000 --> 00:31:01.400 one of the two main female hormones the other being estrogen and it's present in the first 00:31:01.400 --> 00:31:07.600 two weeks of the cycle and has a broadly positive effect on news so this is estrogen. Estrogen 00:31:07.600 --> 00:31:12.520 increases the brain's serotonin the hormone most associated with happiness progesterone 00:31:12.520 --> 00:31:17.040 on the other hand can have a depressing effect so Dr. Peat what do you think about maintaining 00:31:17.040 --> 00:31:26.520 this sentence even just regarding serotonin's positive effects? To be polite I think it's 00:31:26.520 --> 00:31:42.680 very very silly everything there is confused and backwards for example the serotonin thing 00:31:42.680 --> 00:31:57.640 is a happiness signal serotonin is very essential for the inflammation, osteoporosis, cancer, 00:31:57.640 --> 00:32:06.720 blood clotting, spasms all sorts of bad effects inflammatory processes right from an excess 00:32:06.720 --> 00:32:16.360 inflammatory processes dictated by serotonin. Yeah it's right there with histamine as the 00:32:16.360 --> 00:32:23.480 most intense acute local inflammatory signal and in the brain that inflammatory process 00:32:23.480 --> 00:32:34.960 of serotonin turns on the whole stress system that activates ACTH and cortisol. Estrogen 00:32:34.960 --> 00:32:42.480 not only activates that serotonin dependent pathway but it directly activates the adrenal 00:32:42.480 --> 00:32:52.280 glands to produce cortisol so estrogen is a basic stress hormone serotonin is kind of 00:32:52.280 --> 00:33:02.320 a terminal mediator of that stress process turning on the defensive anti-stress cortisol 00:33:02.320 --> 00:33:10.640 production but in itself serotonin is a very powerful bone destroyer by its inflammatory 00:33:10.640 --> 00:33:17.040 process. It's basically an alarm signal no? Yeah. Okay well she without I guess laboring 00:33:17.040 --> 00:33:23.160 that point she mentions as well as creating anxiety another side effect of progesterone 00:33:23.160 --> 00:33:28.840 could be to cause a blues according to research by Torbjorn Backstrom from the University 00:33:28.840 --> 00:33:33.560 of Umeå in Sweden it seems to have the same effect on the brain as depressive drugs like 00:33:33.560 --> 00:33:39.080 alcohol and sleeping pills so where does she get that from that progesterone has this depressant 00:33:39.080 --> 00:33:48.960 effect? That's a very interesting confusion of the meaning of depression in the heart 00:33:48.960 --> 00:34:01.600 for example progesterone depresses the spastic activity that leads to cardiac arrest and 00:34:01.600 --> 00:34:10.560 it depresses the premature contractions and facilitates a good rhythm. Estrogen has the 00:34:10.560 --> 00:34:18.080 opposite effect tends to produce arrhythmia by delaying the ability to regain its energy 00:34:18.080 --> 00:34:26.640 charge and get ready for the next beat. Okay alright so she also goes on to say most substances 00:34:26.640 --> 00:34:31.240 in the body including hormones get broken down into other substances known as metabolites 00:34:31.240 --> 00:34:35.420 before eventually being removed by the kidney or the liver when progesterone is broken down 00:34:35.420 --> 00:34:39.880 its metabolites become active in the brain and it appears they and one in particular 00:34:39.880 --> 00:34:45.960 allopregnanolone that we mentioned last month sorry in March allopregnanolone and pregnanolone 00:34:45.960 --> 00:34:55.120 which both incidentally can be produced in the CNS both in the oligodendrocytes and astrocytes 00:34:55.120 --> 00:35:00.160 so it's not you know you don't have to consume this product it's actually de novo synthesis 00:35:00.160 --> 00:35:05.520 from cholesterol and she says these in particular allopregnanolone binds to a system called 00:35:05.520 --> 00:35:11.640 the GABA-A receptor now we've mentioned and I've talked about the GABA-A receptor in relation 00:35:11.640 --> 00:35:18.040 to things that bind to the GABA-A receptor to produce relaxation like valerian because 00:35:18.040 --> 00:35:26.840 it is the opposite to the excitotoxic system but she says that the GABA-A receptor is a 00:35:26.840 --> 00:35:30.920 little like the brain's police force it regulates making sure there isn't too much excitement 00:35:30.920 --> 00:35:36.400 going on which seems seems okay on the face of it and drugs that bind to it may cause 00:35:36.400 --> 00:35:41.040 it to step up policing and Backstrom's research suggests that metabolites of progesterone 00:35:41.040 --> 00:35:48.080 may be doing the same thing so if female hormones have such distinct effects the next step is 00:35:48.080 --> 00:35:52.560 to wonder why the female body is designed in this way and she suggests that it's more 00:35:52.560 --> 00:35:58.000 a result of evolutionary design meeting modern living progesterone's effects she goes on 00:35:58.000 --> 00:36:02.000 to say may be particularly pronounced now because women are having far more periods 00:36:02.000 --> 00:36:06.600 and far fewer children than in the thousands of malnourished years before birth control 00:36:06.600 --> 00:36:12.920 like birth control as a popular popularly appreciated product anyway 300 years ago women 00:36:12.920 --> 00:36:17.840 started menstruating around 17 or 18 because they were less healthy than today so I'm not 00:36:17.840 --> 00:36:22.000 too sure what you got to say about being less healthy and having a later menarche which 00:36:22.000 --> 00:36:27.320 you've actually said and is well and shown that it's actually a positive thing to actually 00:36:27.320 --> 00:36:32.920 have your period start early is actually related to high estrogen it's actually a very detrimental 00:36:32.920 --> 00:36:40.600 to your long-term health isn't it yeah the age at menarche is getting lower and lower 00:36:40.600 --> 00:36:50.120 all the time over the last several decades and that is now known to correspond to all 00:36:50.120 --> 00:36:58.440 of the the estrogen problems later in life one of the recent groups of studies related 00:36:58.440 --> 00:37:10.280 to the early puberty and the tendency to have autistic babies the uterus during gestation 00:37:10.280 --> 00:37:18.680 it has a higher estrogen level in the women who started at a very young age okay she goes 00:37:18.680 --> 00:37:22.600 on to say that most women got pregnant almost immediately you know several hundred years 00:37:22.600 --> 00:37:28.520 ago without birth control and remain pregnant or breastfeeding for most of their reproductive 00:37:28.520 --> 00:37:36.840 lives which ended around 40 now this this would have subjected them to a fairly sustained 00:37:36.840 --> 00:37:47.520 level of progesterone correct through being pregnant yeah she seems to get it just exactly 00:37:47.520 --> 00:37:57.160 wrong with pregnancy as a time of the low progesterone but the normal cycling woman 00:37:57.160 --> 00:38:05.640 produces maybe 30 milligrams a day during the luteal phase before menstruation and the 00:38:05.640 --> 00:38:15.880 ovaries weighing six or seven grams maybe are working pretty efficiently when they can 00:38:15.880 --> 00:38:24.640 produce 30 milligrams a day but the placenta in the term pregnancy weighs about a pound 00:38:24.640 --> 00:38:35.240 and a half roughly a hundred times bigger than the ovaries and it can produce at least 00:38:35.240 --> 00:38:43.000 30 times as much progesterone per day and there's a an interesting discussion of the 00:38:43.000 --> 00:38:54.120 effect of pregnancy on aging and general health in the book by a a a v everett and others 00:38:54.120 --> 00:39:05.000 called hypothalamus pituitary and aging in which he describes experiments mating rabbits 00:39:05.000 --> 00:39:10.400 constantly as soon as they have a live litter mate them again so that they live their whole 00:39:10.400 --> 00:39:22.800 lives producing a maximum number of litters and others that were not mated the the multi 00:39:22.800 --> 00:39:31.000 litter rabbits were had much more flexible young connective tissue their tissues were 00:39:31.000 --> 00:39:38.000 less aged at the end of their lives than the non-mated and they mentioned studies done 00:39:38.000 --> 00:39:45.880 in Hungary looking at the lifespan of women in relation to the number of babies they had 00:39:45.880 --> 00:39:56.720 produced and graphing it from zero babies to eight babies the maximum that they calculated 00:39:56.720 --> 00:40:07.440 they showed a straight line of life expectancy increasing with each baby that was born and 00:40:07.440 --> 00:40:13.200 in the rabbits they showed that it was this very high constant almost constant exposure 00:40:13.200 --> 00:40:22.480 to progesterone that was protecting reversing the estrogen induced age changes in the connective 00:40:22.480 --> 00:40:28.760 tissue that made them live longer and be healthier. 00:40:28.760 --> 00:40:33.000 Okay good well let's see put the word out there for people that may have questions I 00:40:33.000 --> 00:40:40.000 know several people have called in and haven't got on so far so the area code is 707 923 00:40:40.000 --> 00:40:45.000 3911 and the lights are flashing so in a few moments here we'll take this next call to 00:40:45.000 --> 00:40:47.440 find out where they're from and what the question is. 00:40:47.440 --> 00:40:50.680 Hi caller you're on the air what's your question and where you from? 00:40:50.680 --> 00:40:55.120 Ask him again he was that was quick. 00:40:55.120 --> 00:40:59.360 Okay you're on the air caller so where are you from what's your question? 00:40:59.360 --> 00:41:01.000 Mike from Connecticut. 00:41:01.000 --> 00:41:02.000 Okay Mike what's your question? 00:41:02.000 --> 00:41:06.720 Yes I have a quick question for Dr. Ray Petit just wondering if you had a chance to review 00:41:06.720 --> 00:41:12.160 the recent study that came out of Northwestern University about the correlation with taking 00:41:12.160 --> 00:41:19.360 aspirin daily and the risk of melanoma looks like there's a double the risk in men. 00:41:19.360 --> 00:41:20.960 Dr. Petit. 00:41:20.960 --> 00:41:32.640 I saw that and I don't know what happened with all of the other cancers that have been 00:41:32.640 --> 00:41:38.440 studied aspirin prevents them. 00:41:38.440 --> 00:41:42.740 Yeah I find it strange as well it looks like it was a surprising result versus all the 00:41:42.740 --> 00:41:43.740 other cancers. 00:41:43.740 --> 00:41:49.720 You'll probably find the same thing with the synapse studies and the protect studies on 00:41:49.720 --> 00:41:53.560 progesterone that didn't turn up with positive information you'll probably find the same 00:41:53.560 --> 00:42:01.600 thing either methodology or yeah some of the methodology is probably going to be in question. 00:42:01.600 --> 00:42:08.320 Sure okay and just one more question is what are his thoughts about hydrogen molecular 00:42:08.320 --> 00:42:13.440 hydrogen water and the benefits it looks like there's a few studies coming from Japan looks 00:42:13.440 --> 00:42:16.480 like there's some positive benefits. 00:42:16.480 --> 00:42:27.760 Yeah everything I've seen looks like it's maybe simply reducing the free radical oxidative 00:42:27.760 --> 00:42:34.920 damage substances like lipid peroxides it lowers inflammation in all the experiments 00:42:34.920 --> 00:42:39.120 I've seen. 00:42:39.120 --> 00:42:45.040 Okay that's a question we've got two or three more people on the line waiting so let's take 00:42:45.040 --> 00:42:46.520 this next caller. 00:42:46.520 --> 00:42:48.840 Caller what's your question where you from? 00:42:48.840 --> 00:42:56.080 Yeah from Long Island my question relates to CO2 carbon dioxide therapy you'd mentioned 00:42:56.080 --> 00:43:08.000 bag breathing and I've also heard about dry CO2 baths and I was just wondering if CO2 00:43:08.000 --> 00:43:16.000 is heavier than air can you just put it in a bathtub and how would you measure it because 00:43:16.000 --> 00:43:20.480 if you move around it seems like there'd be quite a bit of disturbance. 00:43:20.480 --> 00:43:29.040 If you get in slowly and get out slowly it's so heavy that you don't flush much of it out 00:43:29.040 --> 00:43:36.960 but you can check with a match or a lighter to find the level the match goes out as soon 00:43:36.960 --> 00:43:39.680 as you sink it into the pure CO2. 00:43:39.680 --> 00:43:43.880 Oh I see and you don't even have to take your clothes off to have a bath. 00:43:43.880 --> 00:43:48.400 How long do you have to stay in there for benefit and how could you do this like once 00:43:48.400 --> 00:43:55.560 a week or something you know like your recommendation on liver for example? 00:43:55.560 --> 00:44:08.880 A 1908 article described it weekly bath in CO2 as being equivalent to a vacation at the 00:44:08.880 --> 00:44:11.680 ocean. 00:44:11.680 --> 00:44:15.280 For how long like at one time if to have effect? 00:44:15.280 --> 00:44:24.080 It gets boring after an hour but you can get a big bag or tub and a plastic tub works fine 00:44:24.080 --> 00:44:30.200 it doesn't have any leaks in it like a bathtub does and you can just sit in it and read or 00:44:30.200 --> 00:44:32.000 watch TV or whatever. 00:44:32.000 --> 00:44:37.920 Okay does that lower your temperature? 00:44:37.920 --> 00:44:45.040 It has a warm sensation when it touches your skin but that's because it's opening up blood 00:44:45.040 --> 00:44:51.720 vessels getting more blood to your skin so you could chill yourself I think if you did 00:44:51.720 --> 00:44:56.960 it in a cold place because it would make you lose heat faster through your skin. 00:44:56.960 --> 00:45:01.720 Does it matter whether it's like food grade or? 00:45:01.720 --> 00:45:03.720 I use it from a welding shop. 00:45:03.720 --> 00:45:09.760 I appreciate your call caller we do have three more people so I just want to make sure they 00:45:09.760 --> 00:45:13.320 all get a chance so let's line up the next caller. 00:45:13.320 --> 00:45:17.280 Caller where are you from and what's your question? 00:45:17.280 --> 00:45:20.040 Hello caller where are you from and what's your question? 00:45:20.040 --> 00:45:25.680 Can you tell me about MitoQ? 00:45:25.680 --> 00:45:34.680 I think that's a new variant of CoQ10 and I don't know whether it's any better I've 00:45:34.680 --> 00:45:37.280 never used it or studied it much. 00:45:37.280 --> 00:45:38.280 Okay thank you. 00:45:38.280 --> 00:45:43.880 Dr. Peate very quickly on CoQ10 and mitochondrial activity do you think there is relative merit 00:45:43.880 --> 00:45:46.800 there for using CoQ10? 00:45:46.800 --> 00:45:53.520 Yeah I think so in many cases a person is not producing enough of it and it happens 00:45:53.520 --> 00:46:05.400 that vitamin K works with CoQ10 and makes it more effective and stable. 00:46:05.400 --> 00:46:13.640 Incidentally in terms of dosage for K2 I noted that one of the kind of more leading producers 00:46:13.640 --> 00:46:22.920 of K2 Thorne Research they produce a liquid vitamin K2 that I know has been recommended 00:46:22.920 --> 00:46:27.360 to people especially if they're using aspirin as a therapy and they use a one milligram 00:46:27.360 --> 00:46:28.720 per drop product. 00:46:28.720 --> 00:46:34.640 Now I've just noticed that Thorne have rebranded their packaging and actually on their supplement 00:46:34.640 --> 00:46:40.600 fact label it says one serving size is now 10 drops and so therefore 10 milligrams is 00:46:40.600 --> 00:46:41.600 a serving size. 00:46:41.600 --> 00:46:47.280 What do you think about K2's use with or without aspirin in that instance if you're mentioning 00:46:47.280 --> 00:46:49.680 its affinity with CoQ10? 00:46:49.680 --> 00:46:55.200 The Japanese have experimented with it at higher levels up to 40 or 45 milligrams per 00:46:55.200 --> 00:47:03.200 day and I've known several people who had extremely high persistently high blood pressure 00:47:03.200 --> 00:47:12.000 like 240 over 140 I think was one person's regular pressure for a year because his blood 00:47:12.000 --> 00:47:20.040 vessels were very calcified and he took 40 or 50 milligrams per day of Thorne vitamin 00:47:20.040 --> 00:47:29.280 K and after a week the pressure was much lower and after two weeks it was essentially normal 00:47:29.280 --> 00:47:33.080 140 over 70. 00:47:33.080 --> 00:47:37.080 Okay we've got two more questions at least, sorry two more callers at least. 00:47:37.080 --> 00:47:41.920 One was what's the dosage for progesterone for a person who's thinking about trying it? 00:47:41.920 --> 00:47:45.900 Yeah that's probably a very variable question, a very variable answer in terms of the use 00:47:45.900 --> 00:47:52.400 it's being used for but what do you think Dr. Peat as a general for a female now presumably 00:47:52.400 --> 00:47:55.120 what a progesterone dose would be? 00:47:55.120 --> 00:48:02.920 And if you're taking it orally in an oil dissolved form 20 or 30 milligrams is a very effective 00:48:02.920 --> 00:48:10.920 dose I've used as much as 100 milligrams myself for a headache it took about two minutes to 00:48:10.920 --> 00:48:11.920 knock out a migraine. 00:48:11.920 --> 00:48:17.040 There you go now you've mentioned again I won't go back to the article because we've 00:48:17.040 --> 00:48:23.740 got callers but the quote-unquote depressing effect of progesterone is it's mildly sedative 00:48:23.740 --> 00:48:29.360 and that's not a depressing effect but I guess in an energy term it is but it has a sedative 00:48:29.360 --> 00:48:30.360 effect doesn't it? 00:48:30.360 --> 00:48:37.640 Yeah it's a powerful sedative if you take enough, 100 milligrams after it knocked out 00:48:37.640 --> 00:48:41.800 the migraine it put me to sleep for a couple hours. 00:48:41.800 --> 00:48:45.640 Okay let's take these next callers, okay so caller you're on the air where are you from 00:48:45.640 --> 00:48:46.640 and what's your question? 00:48:46.640 --> 00:48:49.640 Hi my name is Peter I'm from San Francisco. 00:48:49.640 --> 00:48:50.640 Hey Peter what's your question? 00:48:50.640 --> 00:48:58.080 I had a question regarding the concept of earthing there's a lot of people that promote 00:48:58.080 --> 00:49:02.680 going to the beach going to nature and taking off your shoes and walking around and I felt 00:49:02.680 --> 00:49:06.560 benefit from going to the beach and taking my shoes off and walking around like that 00:49:06.560 --> 00:49:10.200 and coming in contact with the actual earth. 00:49:10.200 --> 00:49:14.520 What does Dr. Peat think is the mechanism behind that if there is any? 00:49:14.520 --> 00:49:26.160 Negative ionized air is more abundant near the ocean or waterfalls I think that's part 00:49:26.160 --> 00:49:33.840 of the good feeling you get at the beach another thing is the skin stimulation of freeing your 00:49:33.840 --> 00:49:43.920 shoes from being imprisoned in shoes and socks that's a very powerful stimulant but supposedly 00:49:43.920 --> 00:49:54.080 the body does the immune system for example reacts to the electrically charged things 00:49:54.080 --> 00:50:03.280 in the environment for example they put nylon on some animals that supposedly was interfering 00:50:03.280 --> 00:50:13.200 with the normal skin ionization and found that their immune systems were suppressed 00:50:13.200 --> 00:50:24.000 and the earth is always a source of electrons actually relative to the higher atmosphere 00:50:24.000 --> 00:50:33.320 you get a gradient with the positive at high altitude and the negative pole at the earth. 00:50:33.320 --> 00:50:36.400 Thanks for your question Cora there's actually a couple more I'm going to hold for one second 00:50:36.400 --> 00:50:40.200 we've still got two more quarters on the line so I hope to get to three now the lights going 00:50:40.200 --> 00:50:48.280 again I just wanted to let you know that the article that was also written that Inger quoted 00:50:48.280 --> 00:50:54.760 in that paper on supposedly progesterone's negative effects the American Congress of 00:50:54.760 --> 00:50:59.760 obstetricians and gynecologists quoted this during some part of her paper that she's written 00:50:59.760 --> 00:51:08.040 in diet and vitamin supplements may help ease PMS the ACOG the American Congress on Obstetrics 00:51:08.040 --> 00:51:14.000 and Gynecologists suggests keeping blood sugar levels up with smaller more frequent meals 00:51:14.000 --> 00:51:19.480 now there's good advice for you okay next caller I wanted to comment one very bad thing 00:51:19.480 --> 00:51:26.080 about her paper was that she was talking about the amygdala activation I know there's so 00:51:26.080 --> 00:51:32.000 many other questions I wanted to ask about it but carry on she was presenting it as a 00:51:32.000 --> 00:51:39.520 negative fear thing but the amygdala regulates affection love anxiety and fear it isn't just 00:51:39.520 --> 00:51:45.040 one sided yeah okay good let me quickly mention to people so they can get online themselves 00:51:45.040 --> 00:51:49.600 and look at this paper then if they want to rewind this radio show or download it from 00:51:49.600 --> 00:52:03.320 the archives her name is Inger sunstorm POROMAA University of Uppsala in Sweden and you know 00:52:03.320 --> 00:52:06.920 what when you type in her name you do that search you'll get directed to research gate 00:52:06.920 --> 00:52:09.960 and you got to scroll through the papers that she's written but you won't find this one 00:52:09.960 --> 00:52:15.960 there what you got to do in the search when you look for it you'll find that it's related 00:52:15.960 --> 00:52:24.920 to PMS and basically you know a treatment for PMS and and those situations where estrogen 00:52:24.920 --> 00:52:30.160 typically is the cause of it and progesterone is the alleviator but when you click on that 00:52:30.160 --> 00:52:33.320 link you'll find her paper and then you'll find what I've mentioned here word for word 00:52:33.320 --> 00:52:37.400 of what she's quoted and then dr. Peat here's refuted it all right so two more callers on 00:52:37.400 --> 00:52:41.240 the line let's take this first this next one hello yeah where you from and what's your 00:52:41.240 --> 00:52:49.880 question I'm I'm Naomi from Willits and I've you've talked about migraine and things that 00:52:49.880 --> 00:52:55.480 can make them can give you a migraine and things that can take it away but I missed 00:52:55.480 --> 00:53:00.420 the first one I think you said biotin and folic acid was a tricky combination that could 00:53:00.420 --> 00:53:07.160 cause migraine and then you said something that I just missed what you said actually 00:53:07.160 --> 00:53:15.320 alleviated it so okay riboflavin and folic acid are the ones that are most irritating 00:53:15.320 --> 00:53:26.080 and getting the intestine free of any of those irritants is very important of a fibrous food 00:53:26.080 --> 00:53:33.120 such as raw carrot or cooked mushrooms helps to clean out the inflammatory substances from 00:53:33.120 --> 00:53:42.160 the intestine but sugar sugar helps to stop the production of histamine and serotonin 00:53:42.160 --> 00:53:51.800 okay and you said some I mean I have a b50 complex with C and it's got all those things 00:53:51.800 --> 00:53:59.680 and I do suffer migraines I don't know if I should be taking riboflavin and folic acid 00:53:59.680 --> 00:54:06.400 if I took one I would have a migraine for about three days I think but I don't that's 00:54:06.400 --> 00:54:14.840 good they're probably protected again what you felt what alleviated migraine progesterone 00:54:14.840 --> 00:54:22.240 sugar and things that stimulate your intestine such as raw carrots and cooked mushrooms to 00:54:22.240 --> 00:54:28.760 remove bowel waste like estrogen and endotoxin progesterone and sugar yeah sugar helps to 00:54:28.760 --> 00:54:38.480 stop the production of histamine and serotonin okay okay thank you very much thank you well 00:54:38.480 --> 00:54:44.820 maybe fascinating show yeah good I don't want to prejudge it but maybe that last call didn't 00:54:44.820 --> 00:54:48.840 really listen to any of the other previous shows where she would recognize that sugar 00:54:48.840 --> 00:54:53.280 is actually very beneficial for you as well just like progesterone and pregnenolone are 00:54:53.280 --> 00:54:57.600 beneficial and that's the cause and the reason that we do these shows is just to help people 00:54:57.600 --> 00:55:01.440 understand that what they hear on the radio or read in the papers is not always the way 00:55:01.440 --> 00:55:07.520 it is and it's driven by fairly powerful interests and lobbies okay we have one more caller so 00:55:07.520 --> 00:55:11.960 let's make this real quick just two minutes caller and then I've got to have to terminate 00:55:11.960 --> 00:55:16.840 you real quick one question you mentioned coq10 what about pqq is that also helpful 00:55:16.840 --> 00:55:24.440 to manufacture and replace damaged mitochondria in conjunction with coq10 what was the name 00:55:24.440 --> 00:55:32.840 of it pqq I can't that's the acronym p qq pure quinolone I've heard about that but never 00:55:32.840 --> 00:55:39.120 studied it okay so that then the other question is before adenine was mentioned that you didn't 00:55:39.120 --> 00:55:43.960 we didn't that's something that's not really mentioned as a b vitamin and I was just wondering 00:55:43.960 --> 00:55:51.080 is that really just an omission for and it should is something that could be taken beneficially 00:55:51.080 --> 00:55:56.360 externally like the other ones that someone went through earlier did you say adenosine 00:55:56.360 --> 00:56:05.360 or I think it's adenine vitamin b4 is what I've heard it referred to as how did you pronounce 00:56:05.360 --> 00:56:13.480 it I guess I thought it was adenine but maybe it's adenosine yeah I think so oh yeah adenosine 00:56:13.480 --> 00:56:22.200 is sort of risky it's the opposite of caffeine in some way and it can bring on symptoms that 00:56:22.200 --> 00:56:30.000 caffeine can alleviate so I wouldn't risk using adenosine that can cause an asthma attack 00:56:30.000 --> 00:56:35.120 for example okay thank you okay thanks for your calls caller thanks so much for joining 00:56:35.120 --> 00:56:40.000 us dr. Peat I really appreciate your time giving it as always okay thank you okay so 00:56:40.000 --> 00:56:44.520 for those people who've listened to this evening show and or who may be called in I think there 00:56:44.520 --> 00:56:53.800 was two other callers that never got through but dr. Peat can be found online at www.raypeat.com 00:56:53.800 --> 00:57:01.680 he's got a pretty big comprehensive library of articles that are fully referenced you've 00:57:01.680 --> 00:57:10.080 heard him speak I've worked with him for a long time and have seen a lot a lot of people 00:57:10.080 --> 00:57:16.920 get beneficial results from his methodologies where other alternatives have not really produced 00:57:16.920 --> 00:57:22.200 as much as I would have hoped so I'm ever forever grateful to his his teaching and his 00:57:22.200 --> 00:57:29.320 wisdom okay so for those people who never listened go check out his website we can all 00:57:29.320 --> 00:57:37.520 I can always be reached at www.westernbotanicalmedicine.com all of the shows are uploaded there they're 00:57:37.520 --> 00:57:44.080 free to download there on the resources tab under ask your herb doctor and for the growing 00:57:44.080 --> 00:57:51.360 YouTube population and the internet population has exploded his his his words his teachings 00:57:51.360 --> 00:57:56.120 his advice is all over the internet and there's different repeat forums and clubs etc which 00:57:56.120 --> 00:58:03.680 spin off different parts of what he has advised anyway go educate yourself you know if you 00:58:03.680 --> 00:58:08.920 don't believe everything that you hear even me go read it go look at it find out for yourself 00:58:08.920 --> 00:58:12.320 you know just do the work and thanks so much for joining us