WEBVTT 00:00:00.000 --> 00:00:04.880 [Music] 00:00:04.880 --> 00:00:12.640 I think it's the situation between the cholecalciferol or the 25-hydroxyform and the 1,25-dihydroxy. 00:00:12.640 --> 00:00:17.680 The relationship is very analogous to what happens when your thyroid is low, 00:00:17.680 --> 00:00:24.240 your actual thyroid hormone. Your body increases the TSH, thyroid stimulating hormone, 00:00:24.240 --> 00:00:31.920 in supposedly a reaction to normalize things, but in fact the TSH itself is an irritant and 00:00:31.920 --> 00:00:39.280 produces the bad symptoms of hypothyroidism as the TSH rises and with a progesterone deficiency. 00:00:39.280 --> 00:00:44.640 The absence of progesterone is one problem, but the fact that when progesterone is low, 00:00:44.640 --> 00:00:51.280 your body increases the luteinizing hormone and the luteinizing hormone is pro-inflammatory 00:00:51.280 --> 00:00:58.160 and creates degenerating symptoms. Anytime the basic functional hormone or material is low, 00:00:58.160 --> 00:01:04.720 the body goes into an emergency reaction in which at the same time that it's trying to correct 00:01:04.720 --> 00:01:13.440 deficiency, it's turning on a substance such as 1,25-dihydroxy D or luteinizing hormone or thyroid 00:01:13.440 --> 00:01:19.840 stimulating hormone, which in the process of adjusting has lots of dangerous toxic side effects. 00:01:19.840 --> 00:01:28.160 In the case of 1,25-hydroxy D, these unwindered side effects include obesity and osteoporosis. 00:01:28.160 --> 00:01:34.160 Welcome to the Win At Life Podcast, a place where we share everything you need to know 00:01:34.160 --> 00:01:39.520 about restoring your metabolism so you can break free from restrictive diets and build a body and 00:01:39.520 --> 00:01:44.880 life you love. I'm Kitty Blomfield, co-founder of NuStrength and your host for this episode and 00:01:44.880 --> 00:01:49.600 today we're joined by our good friend Kate Deering, author of How to Heal Your Metabolism for those 00:01:49.600 --> 00:01:55.280 who listen to the podcast. You'll know who Kate is and if you haven't read her book, I highly 00:01:55.280 --> 00:02:01.760 recommend that you read it. I'll drop a link in the show notes with the discount code so you can 00:02:01.760 --> 00:02:06.320 either buy it from us or you can buy it on Audible, you can pretty much buy it anywhere. But today 00:02:06.320 --> 00:02:13.440 we're also joined by Dr. Ray Peat and we had such great feedback from the podcast that we did with 00:02:13.440 --> 00:02:19.840 him a few months ago so we thought we'd get him on again to talk about vitamin D supplementation. 00:02:19.840 --> 00:02:27.760 Yeah and so we got a series of 30 questions from everybody that we want to talk about and I kind of 00:02:27.760 --> 00:02:33.040 want people to think about when they're listening to this podcast because there's such controversy 00:02:33.040 --> 00:02:38.560 between vitamin D supplements or to take them to not to take them, is you need to see the viewpoint 00:02:38.560 --> 00:02:43.600 of what each argument is coming from and what we've kind of realized is if you're kind of an 00:02:43.600 --> 00:02:52.080 anti-d supplement, you're viewing the organism as maybe calcium is bad and that if you are highly 00:02:52.080 --> 00:02:57.200 calcified that you need to reduce calcium thus reduce vitamin D which if you're looking at 00:02:57.200 --> 00:03:02.720 through that lens that would make sense. However in the bioengine, in your viewpoint or pro metabolic 00:03:02.720 --> 00:03:08.480 view we see calcium quite differently and we see calcium is very metabolic and if somebody 00:03:08.480 --> 00:03:14.480 is calcified it's normally because they aren't getting enough calcium and the usually parathyroid 00:03:14.480 --> 00:03:19.040 hormone or prolactin is increased to pull the calcium from the bone and that's creating the 00:03:19.040 --> 00:03:26.160 calcification. So we actually want more calcium from our diet thus vitamin D would be supportive 00:03:26.160 --> 00:03:30.960 and helping us become less calcified. So I think it's important to kind of think of those things 00:03:30.960 --> 00:03:35.760 as you're listening to this podcast. Again we're not here to tell you what you should think take 00:03:35.760 --> 00:03:43.360 everything in and and decide for yourself but ultimately I think it's a good explanation of 00:03:43.360 --> 00:03:49.600 kind of why vitamin D supplements aren't as bad as many think. Awesome thanks Kate and we'll get 00:03:49.600 --> 00:03:59.120 straight into it. Hello Dr. Ray Peat and Kate Deering we've had Dr. Peat on the podcast previously 00:03:59.120 --> 00:04:03.920 and I was just telling him how much awesome feedback we got from that and it's the most 00:04:03.920 --> 00:04:08.400 downloaded podcast we have on the Win At Life podcast and everyone was saying the information 00:04:08.400 --> 00:04:15.280 was just so valuable and it was really easy to understand. So yeah Dr. Peat thanks so much for 00:04:15.280 --> 00:04:24.240 doing that that podcast. Yeah I just have trouble with my sound system can you hear me now? 00:04:24.240 --> 00:04:28.160 Yep we can hear you perfect and obviously Kate everyone knows Kate Deering she's been on the 00:04:28.160 --> 00:04:32.800 podcast a million times always have a joke it should be the Kitty and Kate show. Kate Deering 00:04:32.800 --> 00:04:38.800 author of how to heal your metabolism. So yeah we just wanted to do a podcast about vitamin D 00:04:38.800 --> 00:04:43.120 supplementation didn't we Kate because I think there's just a lot of confusion out there 00:04:43.120 --> 00:04:49.440 about it. Yeah Kitty and I go back and forth and I know in the community there's a big discussion 00:04:49.440 --> 00:04:53.200 on you know whether you should or should not supplement who should supplement when you should 00:04:53.200 --> 00:04:59.520 supplement or is there other things you could possibly do versus supplement and so Dr. Peat was 00:04:59.520 --> 00:05:05.120 very kind to come on here to offer some clarity and I had decided you know I was going to ask him 00:05:05.120 --> 00:05:12.880 7,000 questions I've limited to about 30 so we thought maybe a 24-hour podcast wasn't going to 00:05:12.880 --> 00:05:18.880 be a good idea so we'll do the best we can to make it as clear and easy to understand as possible. 00:05:18.880 --> 00:05:23.200 Awesome all right well let's just get let's get stuck into it you've got the question or should 00:05:23.200 --> 00:05:27.360 I ask the first question? Yeah go ahead for that first one. Okay all right I'll cut the ribbon. 00:05:28.480 --> 00:05:33.360 Dr. Peat can you please explain how vitamin D3 is utilizing the body? 00:05:33.360 --> 00:05:36.880 What is its purpose? Is it a vitamin or a hormone? 00:05:36.880 --> 00:05:49.120 Those are questions that the best researchers are just now starting to ask for a hundred years 00:05:49.120 --> 00:05:56.800 people were treating it as just a calcium regulator just a bone builder or tooth builder 00:05:56.800 --> 00:06:07.680 and so on and their idea of calcium regulation was very limited. When you realize that calcium 00:06:07.680 --> 00:06:20.480 is involved in every possible cell reaction it's everywhere in everything living and it's a crucial 00:06:21.440 --> 00:06:33.200 regulator and if vitamin D is mainly a calcium regulator then that says the field of vitamin D 00:06:33.200 --> 00:06:43.280 activity is as broad and complex as the whole life question. So what's happening now in vitamin D 00:06:43.280 --> 00:06:54.480 research is just a few dozen people mostly starting to realize what the real issues are 00:06:54.480 --> 00:07:04.880 and so that the field is very open and expanding with really interesting stuff happening. 00:07:05.920 --> 00:07:14.560 For example when you look at it evolutionarily it happens that 00:07:14.560 --> 00:07:29.600 fish don't really depend very much on vitamin D. Some experiments starving fish totally for vitamin 00:07:29.600 --> 00:07:40.320 D. Some of them develop spinal defects but some didn't. Living in the ocean minerals are very rich 00:07:40.320 --> 00:07:50.560 and it happens that even though fish are generally extremely high in vitamin D content 00:07:51.440 --> 00:08:00.080 they don't pay much attention to it. It's very hard to treat a vitamin D deficient fish 00:08:00.080 --> 00:08:09.760 and much of the fish metabolism of vitamin D is getting rid of it. They accumulate it primarily 00:08:10.320 --> 00:08:21.920 from the food they eat the plankton mostly the animal zoa plankton and so it's just mostly a 00:08:21.920 --> 00:08:28.880 waste product for the fish and if you think of the cave fish the blind cave fish 00:08:28.880 --> 00:08:37.360 there's no way they get sunlight or even plankton that has been in the sun 00:08:38.640 --> 00:08:46.560 and still they they manage somehow to have bones and to be alive and so on. 00:08:46.560 --> 00:09:01.760 Apparently caves generally being the result of water carbonic acid in water dissolving away 00:09:02.720 --> 00:09:13.520 limestone cave water is generally very rich in minerals especially calcium so they are an example 00:09:13.520 --> 00:09:24.080 of a vitamin D free vertebrate that gets along with just calcium instead of vitamin D. 00:09:27.120 --> 00:09:33.360 Just real quick so what I hear you saying is are you saying that vitamin D can actually be produced 00:09:33.360 --> 00:09:38.880 in a being without sunlight and it seems that high mineral content would be very important 00:09:38.880 --> 00:09:46.880 to the production of vitamin D? No the cave fish seems to illustrate that the the organism doesn't 00:09:46.880 --> 00:09:56.880 really need a vitamin D if it has lots of calcium and experiments with various fresh and sea water 00:09:56.880 --> 00:10:11.440 fish show that they have a very limited need for it. The abundance of calcium has made them handle 00:10:12.320 --> 00:10:22.960 the whole vitamin D issue mostly as a waste product of eating the the plankton which 00:10:22.960 --> 00:10:33.760 the cholesterol is converted to cholecalciferol by anything exposed to the sun 00:10:35.440 --> 00:10:45.280 and if you eat the material containing cholecalciferol it's as if you're taking a vitamin D 00:10:45.280 --> 00:10:54.880 supplement capsule and when you yourself are in the sunlight your cholesterol is exposed 00:10:54.880 --> 00:11:04.160 ultraviolet light gets all the credit for the conversion of of our cholesterol to cholecalciferol 00:11:04.160 --> 00:11:14.560 but fish experiments show that even incandescent bulbs can activate the conversion of cholesterol 00:11:14.560 --> 00:11:26.560 to cholecalciferol and even injecting irritants into the skin can produce the conversion of 00:11:26.560 --> 00:11:38.240 cholesterol to the pre vitamin D or cholecalciferol so it looks as if the production of pre vitamin D 00:11:38.240 --> 00:11:50.320 or cholecalciferol is a defensive mechanism. Cholecalciferol itself does a whole range of 00:11:50.320 --> 00:12:00.080 protective anti-stress antioxidant anti-radiation protective defensive processes. 00:12:00.080 --> 00:12:10.000 So just for the listener can you basically let them know I mean that the supplemental 00:12:10.000 --> 00:12:17.280 D is essentially cholecalciferol correct? Yeah it's pre vitamin D the same stuff 00:12:17.840 --> 00:12:21.600 that fish eat and that we get out of fish 00:12:21.600 --> 00:12:31.520 and if you think of of people who were in the sunlight constantly 00:12:31.520 --> 00:12:42.400 producing their own conversion of cholesterol to cholecalciferol they were they didn't need 00:12:42.400 --> 00:12:49.440 any from the environment but when you move to the north the only way to survive more than 00:12:49.440 --> 00:13:01.520 a season or so is to start eating some organism that still is in the sun and still producing 00:13:01.520 --> 00:13:09.120 cholecalciferol so you either have to live on the coast and eat fish or 00:13:11.040 --> 00:13:13.440 eat animals which have been in the sunlight 00:13:13.440 --> 00:13:24.400 so the when you're near the equator and have around the year sunlight exposure 00:13:24.400 --> 00:13:35.440 then you can be a vegetarian theoretically without the risk of a vitamin D deficiency. 00:13:37.760 --> 00:13:42.960 So to kind of conclude that I mean what about consuming other foods that are high in vitamin 00:13:42.960 --> 00:13:50.080 D like dairy would that be also supportive? Yeah the cows were in the sunlight 00:13:50.080 --> 00:13:58.880 and so they produced the same material exactly that that fish produced by being in the sunlight 00:13:58.880 --> 00:14:04.720 or by eating that algae that was in the sunlight or zooplankton that was in the sunlight. 00:14:05.440 --> 00:14:10.640 Okay so you're saying that any animal or meat or food product that is actually getting sunlight 00:14:10.640 --> 00:14:18.720 would give some sort of vitamin D to a person? Yeah right except the 00:14:18.720 --> 00:14:27.280 healthy person after that gets into your bloodstream as the cholecalciferol with its own 00:14:28.000 --> 00:14:37.360 whole range of protective effects that your liver hydroxylates it on the number 25 carbon 00:14:37.360 --> 00:14:49.200 and that produces the what we know and measure in the blood as vitamin D it's what some people 00:14:49.200 --> 00:14:56.560 have called the storage form of vitamin D but that doesn't really mean much except that the liver 00:14:57.600 --> 00:15:10.720 does bind enough of the 25-hydroxycholecalciferol to last for a few months and some of it is bound 00:15:10.720 --> 00:15:23.200 on proteins such as calbindin or the calcium binding protein and it passively dissolves 00:15:24.880 --> 00:15:31.840 being fairly fat soluble it dissolves into our fat tissues a moderate amount about the same 00:15:31.840 --> 00:15:42.560 concentration that you find in the bloodstream so the bigger you are the slight slightly greater 00:15:42.560 --> 00:15:54.320 amount is stored in your fat tissues besides what's in your liver and that conversion 00:15:55.120 --> 00:16:00.080 to the hydroxycholecalciferol that happens in the liver 00:16:00.080 --> 00:16:10.480 can be blocked by a liver problem so a person with a sick liver is going to have 00:16:10.480 --> 00:16:23.520 probably enough of the plain cholecalciferol but have a very low level of the 25-hydroxycholecalciferol 00:16:24.400 --> 00:16:34.320 and when you're low very low in that form of the half activated vitamin D 00:16:34.320 --> 00:16:44.720 especially if your calcium intake is limited then you will activate your kidneys 00:16:45.680 --> 00:16:57.360 the traditional story goes that under stress at efficiency of either 25-hydroxycholecalciferol 00:16:57.360 --> 00:17:12.800 or calcium will cause your liver your kidneys to produce 1,25-dihydroxycholecalciferol 00:17:13.760 --> 00:17:26.720 activating the one hydroxylase enzyme in your kidneys but in actuality any inflamed or stressed 00:17:26.720 --> 00:17:36.800 tissue has that ability to make 1,25-dihydroxycholecalciferol the old textbooks 00:17:36.800 --> 00:17:43.920 say it happens only in the kidneys but actually any stress tissue seems to be able to do it 00:17:43.920 --> 00:17:53.680 cancer cells for example are very good at the one hydroxylation which makes the so-called 00:17:53.680 --> 00:18:02.880 active vitamin D okay so I'm gonna I'm gonna wind it back a second because that was a lot of 00:18:02.880 --> 00:18:08.560 information just kind of try to summarize it so that people can kind of understand and because 00:18:08.560 --> 00:18:15.440 there's so much terminology as we know in the in the D world there is obviously D3 or cholecalciferol 00:18:15.440 --> 00:18:21.840 which is the the starting supplementation form and then it does get converted into the 25-OHD 00:18:21.840 --> 00:18:28.080 or the calcium the calcium were what they refer to as stored and maybe that we'll use that term 00:18:28.080 --> 00:18:32.080 if that's okay because I think that's probably easiest to understand it doesn't mean that that's 00:18:32.080 --> 00:18:37.840 it's only form but that's what it's kind of known in in the language and then it does convert into 00:18:37.840 --> 00:18:45.840 the active D and I think what you kind of just explained was that the stored D converts into the 00:18:45.840 --> 00:18:52.240 active D under stress it's not that that is the active form is what is where the active metabolites 00:18:52.240 --> 00:18:58.400 and all the good stuff is it's that it actually converts when the tissue or when the system is 00:18:58.400 --> 00:19:08.400 under stress is that correct yeah I think it's the situation between cholecalciferol or the 25 00:19:08.400 --> 00:19:18.880 hydroxy form and the 1,25-dihydroxy the relationship is very analogous to what happens when your thyroid 00:19:18.880 --> 00:19:27.920 is low your actual thyroid hormone your body increases the TSH thyroid stimulating hormone 00:19:27.920 --> 00:19:38.560 in supposedly a reaction to normalize things but in fact the TSH itself is an irritant 00:19:39.600 --> 00:19:50.480 and produces the bad symptoms of hypothyroidism as the TSH rises and with a progesterone deficiency 00:19:50.480 --> 00:19:58.880 the absence of progesterone is one problem but the fact that when progesterone is low 00:19:58.880 --> 00:20:08.240 your body increases the luteinizing hormone and the luteinizing hormone is pro-inflammatory 00:20:08.240 --> 00:20:19.280 and creates degenerative symptoms any time the basic functional hormone or material is low the 00:20:19.280 --> 00:20:29.520 body goes into an emergency reaction in which it at the same time that it's trying to correct 00:20:29.520 --> 00:20:42.320 the deficiency it's turning on a substance such as 1,25-dihydroxy D or luteinizing hormone 00:20:42.320 --> 00:20:49.360 or thyroid stimulating hormone which in the process of adjusting has lots of dangerous 00:20:50.000 --> 00:21:03.040 toxic side effects in the case of 1,25-hydroxy D these unwanted side effects include obesity 00:21:03.040 --> 00:21:14.800 and osteoporosis for example when the conditions are stressful enough your parathyroid hormone 00:21:15.520 --> 00:21:24.080 increases and it's the major signal for turning on the one hydroxylase enzyme 00:21:24.080 --> 00:21:34.400 that so-called activates the vitamin D and when you're dominated by parathyroid hormone 00:21:35.120 --> 00:21:46.400 and the consequential 1,25-dihydroxy D then you start breaking down your bones and turning off 00:21:46.400 --> 00:21:54.560 your oxidative metabolism blocking the electron transport chain and creating the conditions for 00:21:56.080 --> 00:22:06.560 lactic acid production spreading inflammation degeneration and activating the storage of fat 00:22:06.560 --> 00:22:15.360 creating fat tissue and storing energy and all of the emergency things are activated 00:22:17.360 --> 00:22:26.160 by the stress or inflammation that leads to turning on parathyroid hormone and the main 00:22:26.160 --> 00:22:34.560 two things that will keep your parathyroid hormone down and under control and stop all of those 00:22:34.560 --> 00:22:46.720 degenerative processes the main things are calcium and vitamin D the 25-hydroxy form 00:22:46.720 --> 00:22:53.760 okay so essentially what you're saying is the 1,25 or the active form as a lot of people call it 00:22:53.760 --> 00:23:00.560 D is basically prone and it gives all the inflammatory at high levels of 1,25 D are not 00:23:00.560 --> 00:23:05.440 good and that's when you get a lot of the inflammatory responses weight gain elevated 00:23:05.440 --> 00:23:12.640 lactic acid and so high PTH turns that on and so the only things that are going to parathyroid 00:23:12.640 --> 00:23:17.680 hormone the only things that can actually directly lower the parathyroid hormone are 00:23:17.680 --> 00:23:25.360 calcium and the 25 or the store D or just taking a D supplement or sunlight or whatever is that 00:23:25.360 --> 00:23:36.080 correct yeah and lots of supportive things like sugar keeping your your energy up and preventing 00:23:36.080 --> 00:23:46.160 fat metabolism the stress of too much fat in your diet suppresses the sugar metabolism and 00:23:46.160 --> 00:23:54.080 and again turns on all of those pro-inflammatory processes so essentially keeping the body out of 00:23:54.080 --> 00:24:01.520 stress and so the elevated 1,25 D is just a one of the many responses your body can adjust to when 00:24:01.520 --> 00:24:09.200 under stress and that would gotcha okay and so that's just the first question so we could be 00:24:09.200 --> 00:24:16.880 here for four days um that was super awesome and helpful and I'll and it kind of kind of goes into 00:24:16.880 --> 00:24:23.520 this next question is uh how is getting vitamin D from sunlight different from getting it from a 00:24:23.520 --> 00:24:28.080 supplementation are they metabolized different differently or is it they're at some point of 00:24:28.080 --> 00:24:32.560 time or they are they are at the same space and it doesn't matter where you're getting them from 00:24:32.560 --> 00:24:40.000 you get other good effects from the sunlight but basically as far as the vitamin D is concerned 00:24:40.000 --> 00:24:50.400 I I think they function identically along with the sunlight you're getting visible light 00:24:50.400 --> 00:24:58.160 which is another thing that activates oxidative metabolism in support of the good kind of vitamin 00:24:58.160 --> 00:25:05.600 D gotcha so there obviously there's a lot of other benefits of the sunlight I guess one of 00:25:05.600 --> 00:25:11.520 the things is that we know that usually most people can't they won't overdose on D by getting 00:25:11.520 --> 00:25:17.200 too much sunlight right our body has an innate response it will stop D production once we have 00:25:17.200 --> 00:25:24.240 enough if we're in the sun correct yeah for example you start tanning better when you have enough 00:25:24.240 --> 00:25:33.440 vitamin D you protect yourself more efficiently by starting to produce the melanin pigment but 00:25:33.440 --> 00:25:41.440 the vitamin D itself has an anti-radiation effect so you don't even notice you don't sunburn 00:25:42.800 --> 00:25:47.440 nearly as much what when you're when you have enough of the colecalciferol 00:25:47.440 --> 00:25:57.200 in your tissues it's like a radiation resistance factor okay so for somebody that as I mean I 00:25:57.200 --> 00:26:01.360 definitely have people say that they no longer can tan any longer then when they go out into 00:26:01.360 --> 00:26:09.040 the sun they just burn so would that be a sign that they are low D yeah for most of my life 00:26:09.680 --> 00:26:19.680 I would sunburn very very easily just driving in a closed car through a bright landscape 00:26:19.680 --> 00:26:28.800 my face would get bright red and I would have a shiny red nose from just a few hours of exposure 00:26:28.800 --> 00:26:36.400 sideways through the windows of a car and that isn't a very big dose of 00:26:36.400 --> 00:26:43.440 ultraviolet but I was super sensitive to it and after I started supplementing vitamin D 00:26:43.440 --> 00:26:51.280 I could spend hours outside in mexico at an altitude of seven or eight thousand feet 00:26:51.280 --> 00:27:01.120 super intense radiation and not even get a red nose and why do you think that is why do you think 00:27:01.120 --> 00:27:06.080 that you were not able to get the needed sun or the vitamin D from the sun where that would help 00:27:06.080 --> 00:27:15.440 build up the the supplementation is what worked for you I just didn't uh apparently stay in the 00:27:15.440 --> 00:27:25.840 sun long enough gradually enough once you get the protective level of a vitamin D up then it's easy 00:27:26.560 --> 00:27:35.760 to go ahead and reach a very high level which has the full range of of protective 00:27:35.760 --> 00:27:44.240 anti-stress effects but once once you're deficient the fact that you sunburn so easily 00:27:44.240 --> 00:27:51.120 attempts to make you avoid the sunlight I see so it's essentially like everything else in this 00:27:51.120 --> 00:27:56.000 planet that you need to build up so it's a training mechanism to build up your vitamin D 00:27:56.000 --> 00:28:01.360 levels and your ability to withstand sunlight so it's just that if you did it slow and steady it 00:28:01.360 --> 00:28:08.400 would work it would be just as effective than actually having a supplementation yeah okay um 00:28:08.400 --> 00:28:15.840 I want to go back to when you were talking about the the 25D or the the calcifediol also known as a 00:28:15.840 --> 00:28:22.240 stored D and I think in in a lot of the other communities that talk about it they they say it 00:28:22.240 --> 00:28:28.880 is an inactive form and that this inactive form just can't have any sort of response in our system 00:28:28.880 --> 00:28:34.880 that it's only the 1,25-D that actually has the any sort of response and I know you certainly told 00:28:34.880 --> 00:28:40.240 me that the the calcifediol or the store D does actually have active form and that's the one 00:28:40.240 --> 00:28:45.040 that actually produces all the good stuff in our body can you give us a little more detail about 00:28:45.040 --> 00:28:54.640 that yeah the decisive experiments that show that were the receptor knockout experiments 00:28:54.640 --> 00:29:06.880 the vitamin D receptor supposedly responds to the 1,25-dihydroxy but if you knock out 00:29:07.760 --> 00:29:17.520 that receptor the 25-hydroxy does all of the same functions so neither the receptor nor the 1,25-dihydroxy 00:29:17.520 --> 00:29:27.520 is essential when you have calcium and the 25-hydroxy and and their knockout 00:29:27.520 --> 00:29:38.400 experiments with the one hydroxylase two similar results so that kind of goes back to Gilbert 00:29:38.400 --> 00:29:44.480 Ling's theory that that it's not just about this receptor idea and I know they kind of talk a lot 00:29:44.480 --> 00:29:51.280 about the VDR the the vitamin D receptors in the um anti-D-supplement group and and essentially what 00:29:51.280 --> 00:29:59.920 you're saying is that that doesn't matter yeah the whole cell the whole organism in fact is the real 00:29:59.920 --> 00:30:09.600 receptor because every receptor is sensitive to context and if you take out the so-called 00:30:09.600 --> 00:30:16.080 specific protein that's named the receptor still you have the whole context 00:30:17.680 --> 00:30:24.960 and it turns out that the receptor is just like a an extra leverage point 00:30:24.960 --> 00:30:34.960 for getting the quick easy change of the physiology but as long as you have a living cell 00:30:34.960 --> 00:30:45.760 in the whole organism then the specific receptors are just a part of the story not at all the whole 00:30:45.760 --> 00:30:53.120 picture so essentially the environment that the cell in has plays a huge role in how the cell 00:30:53.120 --> 00:31:00.880 reacts to certain substances yeah the cell is always orienting itself to its environment 00:31:00.880 --> 00:31:08.720 and when you produce an organism without the receptor or the one hydroxylase 00:31:09.920 --> 00:31:16.240 other things take take over and fill in for the lack of that particular thing 00:31:16.240 --> 00:31:26.000 I see okay so I guess just for context it's it's good to know that the the cell will respond 00:31:26.000 --> 00:31:30.320 differently depending on the environment that it's in and if the body is healthier it's going to 00:31:30.320 --> 00:31:35.600 respond differently than if the body is unhealthy and if it's under inflammation and is you're not 00:31:35.600 --> 00:31:40.560 giving it enough sugar or enough other things that cell is going to react very differently than one 00:31:40.560 --> 00:31:47.680 that is properly supported good thyroid function and so forth yeah that's the high energy state 00:31:47.680 --> 00:31:56.320 of the cell which is stable and essentially in a resting and and readiness condition 00:31:58.240 --> 00:32:05.680 if it's lower in energy than any slight disturbance can can throw things off but 00:32:05.680 --> 00:32:13.520 the cell is more oriented and ready to handle its environment when the whole system 00:32:13.520 --> 00:32:23.360 is well energized and well fed gotcha so what about the belief that a vitamin D supplement 00:32:23.360 --> 00:32:29.200 is actually immune suppressive so some people report that they feel better taking a vitamin 00:32:29.200 --> 00:32:34.720 d supplement and then one theory is that well the reason you feel better is is because it is 00:32:34.720 --> 00:32:42.080 suppressing your immune system is what's happening is it's just suppressing the 1-25d and and that's 00:32:42.080 --> 00:32:52.480 what's making you feel better I i think that's part of it part of the confusion is the definition 00:32:52.480 --> 00:33:00.720 of the immune system people talk about wanting to stimulate the immune system but I think that's 00:33:00.720 --> 00:33:12.480 the last thing we we want to do the immune system it means whatever we do to a damaging 00:33:12.480 --> 00:33:21.200 threat some kind of the injury then we say that the immune system has been activated 00:33:21.840 --> 00:33:28.240 but a very healthy organism for example with lots of calcium and vitamin D 00:33:28.240 --> 00:33:35.360 doesn't even notice it isn't harmed by the presence of the pathogen 00:33:35.360 --> 00:33:43.280 so the immune system isn't activated by the really healthy organisms for example 00:33:44.000 --> 00:33:52.320 98 percent of the really healthy people don't mind having the covid virus it's a minor 00:33:52.320 --> 00:34:01.600 irritant or disturbing effect when your cells are in a stable highly energized condition 00:34:01.600 --> 00:34:10.560 it's only the borderline low energy inflamed condition of old age or existing sickness 00:34:11.760 --> 00:34:20.240 that makes something like the covid virus or a bacterium or whatever a fungus 00:34:20.240 --> 00:34:33.600 or a toxin and so on the body doesn't get damaged when it's in a healthy energized condition 00:34:34.960 --> 00:34:43.200 right so I'm going to take a little turn and and say there are some researchers that are utilizing 00:34:43.200 --> 00:34:51.040 like a really low vitamin D status to address autoimmune issues and they're saying that if 00:34:51.040 --> 00:34:58.400 they suppress the d status to well below 12 that they're actually getting responses where people 00:34:58.400 --> 00:35:05.200 are recovering from an autoimmune issue is there some explanation for that that would be the 00:35:05.200 --> 00:35:08.960 Trevor Marshall people that would be them correct 00:35:08.960 --> 00:35:23.120 the I don't like to even call it reasoning it's the application of an engineering 00:35:23.920 --> 00:35:33.200 metaphor to biology and an electrical engineer for example thinks in terms of hard wiring 00:35:33.200 --> 00:35:42.240 and switches and the flow of current and so on and so the idea of receptors 00:35:44.320 --> 00:35:53.920 and the innate immune processes and all of that fits very well with 00:35:53.920 --> 00:36:02.800 an engineering orientation and a lot of if not all of Trevor Marshall's 00:36:04.000 --> 00:36:14.160 ideas are based on what he calls computer modeling and in 2006 he referred to the 00:36:14.160 --> 00:36:22.160 Olmesartan and similar angiotensin receptor inhibitors 00:36:24.240 --> 00:36:34.960 called them antagonists of the vitamin D receptor but then in 2017 he was calling them agonists of 00:36:34.960 --> 00:36:44.240 the vitamin D receptor and saying they restored the vitamin D receptor function and what they 00:36:44.240 --> 00:36:53.520 empirically are doing with a mild dose of minocycline it happens to be a very effective 00:36:53.520 --> 00:37:04.800 anti-inflammatory agent as well as an antibiotic or antibacterial and the sartans, olmesartan or 00:37:04.800 --> 00:37:14.960 losartan those are very basic effective anti-inflammatory agents and so when you're 00:37:14.960 --> 00:37:23.600 talking about autoimmune and degenerative diseases both anti-inflammatory agents 00:37:23.600 --> 00:37:30.240 minocycline and olmesartan are going to reduce the symptoms and 00:37:33.760 --> 00:37:42.960 I don't think they have any particular either antagonist or receptive or a restorative effect 00:37:42.960 --> 00:37:50.960 on the vitamin D receptor so so yeah Trevor Marshall uses I think it's venicar to treat 00:37:50.960 --> 00:37:58.480 a lot of his patients which is a angiotensin 2 receptor antagonist blood pressure medication but 00:37:58.480 --> 00:38:04.640 what you're saying is that it may be not even the the suppression of vitamin D that's making 00:38:04.640 --> 00:38:10.800 the difference it might just be these medications are making the difference yeah I don't think he 00:38:10.800 --> 00:38:20.000 presents any evidence at all that it has anything to do with the vitamin D receptor it was originally 00:38:20.000 --> 00:38:31.920 based on so-called computer modeling no experiments really and and then he changed his from antagonist 00:38:31.920 --> 00:38:45.120 to agonist and in in fact the sartans in general are very powerful anti-inflammatory protective 00:38:45.120 --> 00:38:53.920 agents regardless of whether it's rheumatoid arthritis that's the problem or covid infection 00:38:53.920 --> 00:39:04.320 it's a general all-purpose anti-inflammatory protective substance right I remember you talking 00:39:04.320 --> 00:39:11.120 about losartan being used in in covid and helped people get through covid so I would imagine that 00:39:11.120 --> 00:39:19.360 these other ones would work as well very interesting um okay so flipping again could 00:39:19.360 --> 00:39:30.160 could store d status be a sign of sickness meaning if somebody's d is low um does that mean that they 00:39:30.160 --> 00:39:36.960 are sick or does that or like another argument is does is it actual need for more d or is it just a 00:39:36.960 --> 00:39:43.680 sign that they may be sick and that restoring their health would correct their d 00:39:43.680 --> 00:39:56.400 um if a person is taking large amounts of a vitamin D supplement and or getting sunlight 00:39:57.040 --> 00:40:08.160 and still they're circulating uh 25-hydroxycholecalciferol if that is still low I think that 00:40:08.160 --> 00:40:16.400 means they have a liver inflammatory problem because the liver is a major part that creates 00:40:16.400 --> 00:40:25.360 the 25 hydroxy active form but I i think most of the background of the question has to do with the 00:40:26.160 --> 00:40:34.720 Trevor Marshall's doctrine that there are occult organisms inside cells causing sickness 00:40:34.720 --> 00:40:45.280 and that his protocol is the way to eventually eliminate those occult organisms 00:40:45.280 --> 00:40:54.880 so let's say somebody was taking a decent amount of d of getting sunlight and had like I said low 00:40:54.880 --> 00:41:00.480 d level still their store d was quite low what would you at that point recommend would you say 00:41:00.480 --> 00:41:04.080 continue to take more d or is there something else that we need to look at 00:41:04.080 --> 00:41:12.480 yeah the whole picture of what could be the source of inflammation and liver injury 00:41:12.480 --> 00:41:19.440 but taking vitamin D isn't going to make the problem worse the way the 00:41:20.160 --> 00:41:29.840 Trevor people Marshall people say it will okay so at that point what about for somebody who takes 00:41:29.840 --> 00:41:39.920 a d supplement and it makes them feel absolutely horrible what would happen I've been hearing from 00:41:39.920 --> 00:41:49.200 a few people who were deteriorating rapidly one thought she was approaching death with 00:41:49.200 --> 00:41:59.280 neurological and all kinds of other symptoms and I looked at her diet and supplements and she was 00:41:59.280 --> 00:42:07.440 supplementing things in a base of medium chain triglycerides and when she stopped everything 00:42:07.440 --> 00:42:18.800 containing mct all of her symptoms went away and there's one study in which in animals they found 00:42:18.800 --> 00:42:28.960 that a peanut allergy for example was created in the presence of mct it affects the immune system 00:42:29.920 --> 00:42:37.280 on the lining of the intestine in a way that destroys our ability to resist 00:42:37.280 --> 00:42:46.160 andogens and allergens and makes us susceptible to food allergy symptoms 00:42:46.160 --> 00:42:55.280 that's interesting I mean the one supplement I usually recommend is carlson's and that is in mct 00:42:55.280 --> 00:43:02.960 oil so you are saying to avoid the ones in mct oil or if it's if it is creating an irritation 00:43:02.960 --> 00:43:08.160 it could be the oil might might be okay are they okay to have in mct oil is there one that you 00:43:08.160 --> 00:43:15.360 know of that is good that is not in those things a lot of people get benefit from them but I think 00:43:16.080 --> 00:43:26.720 some of the intense bad reactions stop happening when they use a olive oil at base vitamin D 00:43:26.720 --> 00:43:32.480 there are several companies that that make a pure olive oil and vitamin D 00:43:32.480 --> 00:43:39.920 product either in drops or capsules okay do you happen to know any offhand that we don't remember 00:43:40.960 --> 00:43:48.880 no I don't remember just look for the price at that very tremendously in in cost so a vitamin D 00:43:48.880 --> 00:43:55.040 in olive oil would would be where to try if if you are currently taking a d supplement and having a 00:43:55.040 --> 00:44:06.080 bad reaction and I think so lead at low d status okay um what about let's kind of flip into maybe 00:44:06.080 --> 00:44:12.560 talking a little about the calcium and d um kind of communication and how they're all intertwined 00:44:12.560 --> 00:44:25.280 with each other and so well I'm gonna go back real quick um if somebody has low d could it also mean 00:44:25.280 --> 00:44:31.680 other things meaning I certainly read some research showing that just taking magnesium 00:44:31.680 --> 00:44:40.480 can raise store d levels so it would it make sense for someone to actually explore other avenues 00:44:40.480 --> 00:44:48.560 before taking a d supplement like looking at some of the co-factors that go into vitamin D metabolism 00:44:48.560 --> 00:44:59.840 yeah for example including milk and cheese in your diet is a good first step to to see whether it 00:44:59.840 --> 00:45:06.240 might be a calcium magnesium deficiency because those both of those have 00:45:06.240 --> 00:45:17.120 both of both an activating and stabilizing protective potentially sedating action 00:45:17.120 --> 00:45:25.600 a quieting effect on inflammation for example so deficiency of either magnesium 00:45:26.880 --> 00:45:38.240 or calcium can lead to the inflammatory condition that activates the 125 dihydroxy d 00:45:38.240 --> 00:45:46.000 okay so just being low right in calcium or magnesium will initiate an inflammatory response 00:45:46.000 --> 00:45:53.440 which will pull the 25 of the store d down and will elevate your 125 active d numbers 00:45:53.440 --> 00:46:04.000 is that correct yeah okay okay so our here's an interesting question are high cholesterol levels 00:46:04.000 --> 00:46:11.920 and low vitamin D status correlated since cholesterol is the precursor for d yeah in 00:46:11.920 --> 00:46:22.800 old people for example the vitamin D that is active in the skin is greatly reduced 00:46:22.800 --> 00:46:30.480 and that shows that the cholesterol 00:46:30.480 --> 00:46:41.040 is a major reason that aging reduces vitamin D production they just aren't putting the 00:46:41.040 --> 00:46:45.520 cholesterol in the position to be activated by sunlight 00:46:45.520 --> 00:46:53.920 so then it would be fair to say that possibly taking a statin or any cholesterol 00:46:53.920 --> 00:46:56.880 lowering medication is certainly going to affect your vitamin D status 00:46:56.880 --> 00:47:05.200 yeah it affects everything including vitamin D status okay so that would be certainly something 00:47:05.200 --> 00:47:10.400 to look at would it be more something if your cholesterol was high would it would you first 00:47:10.400 --> 00:47:20.960 look at something like thyroid function or a neural deficiency in the 1930s into the 1940s 00:47:20.960 --> 00:47:31.440 hypothyroidism was very commonly diagnosed by elevated cholesterol and over and over 00:47:32.160 --> 00:47:39.520 experimenters within people who had had their thyroid plan removed and in animals showed that 00:47:39.520 --> 00:47:52.400 thyroid reliably lowers cholesterol as it increases the metabolic rate it's a very predictable event so 00:47:52.400 --> 00:48:03.600 the whole hypercholesterolemia culture grew up along with the suppression of the existing 00:48:03.600 --> 00:48:13.840 knowledge of thyroid hormone function so essentially if somebody is high cholesterol I mean not not that 00:48:13.840 --> 00:48:19.360 you need to take a thyroid but obviously improving thyroid function whether it's for proper diet or 00:48:19.360 --> 00:48:24.640 de-stressing that alone without even taking a d supplement could improve their d status 00:48:24.640 --> 00:48:37.280 yeah the thyroid and vitamin D and calcium are intimately interrelated you can't separate 00:48:37.280 --> 00:48:47.680 the thyroid from the vitamin D and calcium metabolism gotcha okay um what about can we 00:48:47.680 --> 00:48:53.840 actually store enough d for the winter months is is that what the summer is all about and 00:48:53.840 --> 00:48:58.560 essentially for those people that obviously don't have a lot of summer months are they 00:48:58.560 --> 00:49:03.280 going to be able to get enough d during those months so that will take care of them during 00:49:03.280 --> 00:49:08.640 the winter or for those people is it pretty evident that they'll need to be taking some 00:49:08.640 --> 00:49:13.920 sort of supplementation or certainly eating foods that are certainly high in vitamin D 00:49:15.040 --> 00:49:22.880 if they have really been in the sun during the summer they will assuming that their liver is 00:49:22.880 --> 00:49:30.240 fairly healthy their liver is going to store enough for several months of the darkest part 00:49:30.240 --> 00:49:37.360 of winter but it really depends on how much time they spend outside during the summer 00:49:38.080 --> 00:49:46.160 and also how good their thyroid status is and their general metabolism but yes 00:49:46.160 --> 00:49:56.640 the reason eating fish liver or beef liver or whatever is a good source of vitamin D 00:49:56.640 --> 00:50:02.800 is that the liver does store a considerable amount of vitamin D 00:50:04.640 --> 00:50:11.120 okay so kind of getting on that so would you and I know you've gone um and said kind of good 00:50:11.120 --> 00:50:17.680 and bad so would you say that cod liver oil would be an okay way to supplement vitamin D 00:50:17.680 --> 00:50:29.280 except that it comes with a considerable amount of fish oil yes and fish oil over time 00:50:30.080 --> 00:50:39.760 tends to accumulate with pro estrogen effects pro inflammatory pro aging anti thyroid effects 00:50:39.760 --> 00:50:47.840 so I don't think it's the best way to get your vitamin D and vitamin A but it is a 00:50:47.840 --> 00:50:57.760 source in an emergency better to use cod liver oils and to be deficient in vitamin D 00:50:58.720 --> 00:51:05.760 right but something like beef liver or whole milk would be better options much much better 00:51:05.760 --> 00:51:13.680 okay and what about let's say milk that has been fortified with vitamin D is that safe 00:51:13.680 --> 00:51:25.760 the choice of emulsifiers I'm not sure how much latitude there is but I've heard that 00:51:26.320 --> 00:51:36.000 polysorbate 80 and polyethylene glycol have been used as emulsifiers for the vitamin A and vitamin D 00:51:36.000 --> 00:51:43.760 and since some people are very allergic to those polymers you have to 00:51:43.760 --> 00:51:53.840 be watchful if you have an allergic reaction to milk try a milk that hasn't been 00:51:55.200 --> 00:52:03.360 supplemented which usually means buying whole milk which hasn't been pasteurized then you can skim it 00:52:03.360 --> 00:52:13.520 to reduce the very high fat content of the whole milk and get an unadulterated natural milk 00:52:13.520 --> 00:52:19.760 right and that's one thing I certainly remember I mean over in the states we know that all low fat 00:52:19.760 --> 00:52:26.960 milk is has additives of A and D in it I don't think there are any that don't that are low fat 00:52:26.960 --> 00:52:32.800 and I know you consume a lower fat milk and I usually consume a milk like straws where you can 00:52:32.800 --> 00:52:39.040 actually skim the fat now if I was to skim the fat aren't I removing a lot of the A and the D that 00:52:39.040 --> 00:52:48.480 I'm trying to get yeah but a moderate amount like one or two percent fat is all you need for the 00:52:48.480 --> 00:52:55.440 vitamins if the cows are healthy okay okay and then you I know you use a lower fat milk do you 00:52:55.440 --> 00:53:02.880 have a brand that you prefer that seems to do okay for you uh no I just get whatever tastes good 00:53:02.880 --> 00:53:12.080 some of the organic milks have a really bad taste and that means their cows were eating 00:53:12.640 --> 00:53:21.680 some kind of odd weeds that I don't like so I go by the taste okay so the so does your grocery 00:53:21.680 --> 00:53:26.080 store kind of let you taste test when that would be nice if we could all like you know it like going 00:53:26.080 --> 00:53:32.960 to a winery you could taste your milk before you purchased it that would be nice but I just don't 00:53:32.960 --> 00:53:39.680 buy it again when it tastes too bad that's probably good advice Kitty what do you do for your milk are 00:53:39.680 --> 00:53:46.480 you are you still there I am still here I um we drink low-fat milk Craig likes skim milk because 00:53:46.480 --> 00:53:51.040 he drink I think skim is what the equivalent because you guys call it different things 00:53:51.040 --> 00:53:57.120 we call it low-fat yes you've got one percent and then yeah he drinks the like the really low fat 00:53:57.120 --> 00:54:00.960 loads he drinks loads of milk I drink the low fat but we're so lucky over here we don't they're not 00:54:00.960 --> 00:54:06.720 fortified with vitamins which is so awesome so yeah we just get them from our there's a couple 00:54:06.720 --> 00:54:14.320 of local um dairies that we support that we get our milk from um which is really good but yeah I 00:54:14.320 --> 00:54:18.160 really feel for all our american and overseas clients because they're always posting about how 00:54:18.160 --> 00:54:25.200 they just can't find milk low-fat milk without the added vitamins yeah so I think the takeaway is 00:54:25.200 --> 00:54:30.640 yet you know you can either buy a milk that's full and try to skim the fat or you know try other ones 00:54:30.640 --> 00:54:34.720 and if they taste good you know and and you don't have some sort of reaction to it then it's a good 00:54:34.720 --> 00:54:39.760 milk but some people I find when reintroducing milk that whole seems to be the easiest route 00:54:39.760 --> 00:54:44.480 because they seem to tolerate the best at least in the beginning so um that's my general advice on 00:54:44.480 --> 00:54:56.560 that okay uh still got a bunch so everybody put on their seat belt um so Ray when we measure the 00:54:56.560 --> 00:55:04.640 stored vitamin D or the calcidiol uh in the blood is is this an accurate number because I always hear 00:55:04.640 --> 00:55:09.440 about there's certain things like estrogen and iron that you know really doesn't matter what's 00:55:09.440 --> 00:55:14.880 in the blood it's because it's in the tissue is this a similar case for stored D because there 00:55:14.880 --> 00:55:24.640 obviously is a lot in the tissue as well um uh no the circulating in the blood you have the 00:55:25.440 --> 00:55:36.000 vitamin D binding protein as well as the lipids in the blood that are carrying a large amount of it 00:55:36.000 --> 00:55:52.320 so it the fat tissues passively act as storage but at a level not much higher than in the blood 00:55:53.760 --> 00:56:07.360 and when it's in the muscles nerves and so on no one has measured the extracting those 00:56:07.360 --> 00:56:21.120 vital tissues to see how much of the 25 hydroxy is inside the cells it's assumed that the cells will 00:56:22.000 --> 00:56:31.440 take up according to what they need probably very similar to the blood level I see I think 00:56:31.440 --> 00:56:37.120 you once told me that if you are have a good amount of body fat on you though won't your body 00:56:37.120 --> 00:56:44.400 store more of that D in the tissue so maybe your numbers won't be as high and that might also be to 00:56:44.400 --> 00:56:53.840 due to a liver issue the level in the fat tissue corresponds pretty closely to the concentration 00:56:53.840 --> 00:57:01.360 in the blood so if you have a very big volume of fat tissue at that same concentration then yeah 00:57:01.360 --> 00:57:11.840 that will act as a storage supplementing what's in your liver I see I see so let's talk about the 00:57:11.840 --> 00:57:17.600 optimal number of your stored D like what number because obviously some people promote that 00:57:17.600 --> 00:57:24.400 anything above 20 doesn't make any sense so there's no biological reason for you or advantage to be 00:57:24.400 --> 00:57:33.200 above 20 and obviously I think you'd promote more of a 40 to 60 number so what would you say 00:57:33.200 --> 00:57:37.120 obviously that is what you would say but why would you say the number needs to be higher 00:57:37.120 --> 00:57:45.760 and and the reasoning behind that one of the functions is to keep your 1,25-dihydroxy 00:57:45.760 --> 00:57:57.920 D as low as possible by keeping your parathyroid hormone low so having excess calcium in in your 00:57:57.920 --> 00:58:08.960 diet and a generous amount of the 25-hydroxy D that is acting as sort of a buffer against 00:58:08.960 --> 00:58:16.560 any of the irritants and inflammatory de-energized conditions that would threaten to 00:58:17.360 --> 00:58:32.560 increase your parathyroid hormone and 1,25-dihydroxy so your go ahead the practical level like improving 00:58:32.560 --> 00:58:42.480 sleep for example being resistant to sunburn that pretty much happens above 50 nanograms 00:58:42.480 --> 00:58:51.680 per milliliter 50 to 70 seems to be the safe range where it's acting as a buffer 00:58:51.680 --> 00:59:01.360 to reduce stress generally and what about some people I mean can you go too high I mean obviously 00:59:01.360 --> 00:59:06.320 you're not going to go higher than that if you're if you're getting natural sunlight but if you were 00:59:06.320 --> 00:59:13.200 supplementing I mean what what dangers are there if you if you go to 80 or 90 or 100 people working 00:59:13.200 --> 00:59:23.920 outdoors for example as a lifeguard have measured 130 nanograms per milliliter and higher 00:59:24.800 --> 00:59:35.600 and there's no harm evident at all but with a moderate overdose of 1,25-dihydroxy you can easily 00:59:35.600 --> 00:59:44.720 create hypercalcemia calcification of of soft tissues demineralization of your bones 00:59:45.680 --> 00:59:56.400 and other degenerative signs so as long as your calcium intake and 25-hydroxy are in that range 00:59:56.400 --> 01:00:08.000 I don't know if anyone who has had 200 nanograms per milliliter but no matter how much sun 01:00:08.800 --> 01:00:20.880 exposure you get maybe 150 ng per ml would be a an upper healthy limit but 01:00:20.880 --> 01:00:29.200 it's the keeping keeping the 1-25 down preventing the parathyroid hormone 01:00:29.200 --> 01:00:33.840 from creating the degenerative inflammatory processes 01:00:35.680 --> 01:00:45.120 so I mean I've read research that will show that a there are healthy people that actually have a low 01:00:45.120 --> 01:00:52.560 25d stored D also a low 1,25d and that would be a healthy person and it's the unhealthy person that 01:00:52.560 --> 01:01:04.320 has a elevated or low 25d but then a very elevated 125d I mean can you be healthy with a number 01:01:04.320 --> 01:01:18.400 of 20 for a store d number temporarily I I just think the the long range outlet 01:01:18.400 --> 01:01:22.240 is better when you're in the higher range because you're 01:01:26.160 --> 01:01:39.840 having a buffer effect actually of an excess beyond what's essential of calcium and 25 hydroxy 01:01:39.840 --> 01:01:48.480 it gives you the opportunity to undergo some stress without tearing down your bones 01:01:48.480 --> 01:01:55.840 and calcifying your arteries okay so for someone that maybe doesn't have a lot of stress in their 01:01:55.840 --> 01:02:02.160 life and you know is living inside but not really very stressed that could totally work but obviously 01:02:02.160 --> 01:02:07.840 in today's modern society with a good amount of stress that would not be an ideal number to be 01:02:07.840 --> 01:02:15.440 protected for the long haul yeah I think so okay okay so let's talk about the vitamin D kind of 01:02:15.440 --> 01:02:22.240 calcium connection and because obviously I know you definitely your big things that you'd like to 01:02:22.240 --> 01:02:27.760 promote thyroid calcium vitamin D and how they all intertwine with each other can you just give me a 01:02:27.760 --> 01:02:38.160 brief synopsis of how vitamin D and calcium and thyroid all affect each other I'm keeping the 01:02:38.160 --> 01:02:50.880 calcium bound up so that it doesn't act as an excitement to cells the danger when your energy 01:02:50.880 --> 01:03:03.920 is low or inflammation is high is that calcium becomes a cell exciter activates a breakdown of 01:03:03.920 --> 01:03:16.640 protein nucleic acids and the activation of all of the processes that lead to eventually cell death 01:03:17.600 --> 01:03:32.000 or loss of function and the vitamin D of the right sort is functioning to activate the proteins 01:03:32.000 --> 01:03:43.200 that hold vitamin D in a safe condition and in that condition vitamins or calcium is 01:03:45.200 --> 01:03:54.560 working with progesterone and thyroid as cell stabilizers as having actually a sedative effect 01:03:54.560 --> 01:04:09.040 an injection of calcium salts can act as an analgesic and as a sedative by 01:04:11.200 --> 01:04:21.280 promoting the stable relaxed conditions simply being low in energy or having inflammatory signals 01:04:21.280 --> 01:04:33.200 will activate the improper functions such as calcification of your blood vessels and other 01:04:33.200 --> 01:04:46.160 soft tissues and that's where at 1,25-dihydroxy becomes a danger it has a brain excitatory effect 01:04:46.160 --> 01:04:56.720 which can can seem very good momentarily but at exactly the same process that makes it a brain 01:04:56.720 --> 01:05:08.400 excite and makes it a blood vessel calcifier by destabilizing the relation between calcium 01:05:08.400 --> 01:05:17.040 and the structure of the cell so I think one of the confusions about calcium is because you always 01:05:17.040 --> 01:05:23.440 hear about people are calcified and calcified arteries and blood vessels and their tissue and 01:05:23.440 --> 01:05:28.560 so people are constantly being told you don't need any more calcium everything's calcified 01:05:28.560 --> 01:05:34.960 and can you kind of explain what is really happening so that we can understand that obviously 01:05:34.960 --> 01:05:39.200 don't want to be calcified but is it due to the fact that somebody is eating too much calcium 01:05:39.200 --> 01:05:49.760 no it's the same situation with kidney stones people who don't eat enough calcium 01:05:52.080 --> 01:06:01.520 or don't get enough of the right kind of vitamin D tend to get calcium kidney stones 01:06:01.520 --> 01:06:11.360 and the mechanism seems to be that your parathyroid hormone increases at your 01:06:12.080 --> 01:06:22.480 aldosterone and a whole inflammatory system increases the the angiotensin system becomes 01:06:22.480 --> 01:06:36.320 activated and the excitation goes with unopposed phosphate action if you have too much phosphate 01:06:36.320 --> 01:06:47.840 in your diet that activates the calcification process partly by a direct solubility effects 01:06:47.840 --> 01:06:54.800 inside cells but mostly through activating overproduction of parathyroid hormone 01:06:54.800 --> 01:07:03.280 so when you talk about getting extra protective calcium in your diet 01:07:04.160 --> 01:07:13.440 that means relative to somewhat lower phosphate in your diet because both of those effects 01:07:13.440 --> 01:07:22.640 will lower your parathyroid hormone and the angiotensin system and adrenal stress hormones 01:07:22.640 --> 01:07:30.640 all of which protects the blood vessels and other soft tissues from calcification 01:07:33.360 --> 01:07:45.680 injection of the 1,25-dihydroxy will have exactly the opposite effect or an overdose of parathyroid 01:07:45.680 --> 01:07:57.440 hormone activating the 1,25-dihydroxy will pull calcium out of your bones give you hypercalcemia 01:07:58.720 --> 01:08:10.560 and create crystals of calcium and phosphate inside your living cells causing them to first become 01:08:10.560 --> 01:08:19.760 excited overactive stress producing excess collagen excess nitric oxide 01:08:20.800 --> 01:08:29.760 and a whole process of degenerative damage leading to a formation of bone 01:08:29.760 --> 01:08:33.520 fibrous hardening and calcified fiber 01:08:33.520 --> 01:08:45.200 so it's essentially the opposite so it's not due to ingesting calcium that's creating the issues 01:08:45.200 --> 01:08:52.000 it's essentially a lack of calcium and a high phosphorus diet that's triggering the parathyroid 01:08:52.000 --> 01:08:58.560 hormone to pull calcium from the bones and then that is what essentially is creating all this 01:08:58.560 --> 01:09:06.000 calcification yeah it's been known now for decades that women with the worst osteoporosis 01:09:06.720 --> 01:09:18.320 have the most calcified blood vessels gotcha and so obviously and this is obviously why you 01:09:18.320 --> 01:09:24.240 definitely promote a high calcium to phosphorus diet which essentially is a high dairy diet and 01:09:24.240 --> 01:09:34.640 low grain and meat diet is that my very reason yeah grains like humus nuts meats and fish all 01:09:35.600 --> 01:09:43.200 can create an excess of phosphate in the system activating your parathyroid hormone 01:09:43.200 --> 01:09:50.480 and during the night just the stress of the darkness of a single night 01:09:50.480 --> 01:10:00.720 increases your parathyroid hormone and the if you measure the calcium output in the urine 01:10:01.840 --> 01:10:11.440 of a person who is developing osteoporosis most of the day's calcium loss is in the morning urine 01:10:11.440 --> 01:10:19.920 because of the elevation of parathyroid hormone during the night breaking down the bones putting 01:10:19.920 --> 01:10:27.520 making you relatively hypercalcimic hardening your arteries and other tissues 01:10:28.720 --> 01:10:35.360 and so especially at bedtime milk and vitamin D 01:10:35.360 --> 01:10:46.960 are protective against this constant nocturnal loss of calcium so just another reason to have 01:10:46.960 --> 01:10:55.600 milk and honey before you go to bed to help with that process is that one reason why people are 01:10:55.600 --> 01:11:03.280 always so stiff in the morning yeah lots of inflammatory things develop during the night 01:11:03.280 --> 01:11:11.600 if you look at all of the blood changes within about an hour or two 01:11:11.600 --> 01:11:21.840 or by the middle of the night all of the degenerative stress hormones have increased 01:11:22.720 --> 01:11:33.040 free fatty acids which are toxic to all of the cells by interrupting your oxidative 01:11:33.040 --> 01:11:42.480 use of glucose the free fatty acids rise steadily during the night along with cortisol 01:11:44.400 --> 01:11:56.000 serotonin estrogen angiotensin parathyroid hormone and all of the things that take take our tissues 01:11:56.000 --> 01:12:04.800 apart so that's essentially why we're trained to sleep at night right to go into the least 01:12:04.800 --> 01:12:10.240 stressed position we possibly can because of all of these things that are happening in our 01:12:10.240 --> 01:12:16.080 system just based on the darkness yeah people have had their blood tested every 15 minutes 01:12:16.080 --> 01:12:28.240 while either awake during the night or while asleep during the night and if you are soundly 01:12:28.240 --> 01:12:35.680 sleeping during the night you'll have a moderate increase of the stress hormones but when you're 01:12:35.680 --> 01:12:43.600 not sleeping the darkness is several times more destructive all of the stress hormones 01:12:43.600 --> 01:12:53.920 rise more quickly when you're not asleep so sleep is our obviously adaptive reaction to 01:12:53.920 --> 01:13:01.200 avoiding those stresses right so if you're a shift worker and have to stay up at night probably 01:13:01.200 --> 01:13:07.440 something that would help you would be milkshakes and milky drink or high calcium foods or so forth 01:13:07.440 --> 01:13:14.960 to help kind of support the system during that nighttime yeah and everything that protects 01:13:14.960 --> 01:13:31.680 against the shift to fat metabolism of free fatty acids the 1,25-dihydroxy vitamin D is able to turn 01:13:31.680 --> 01:13:41.440 off the oxidative metabolism causing a shift over to the fat dependent metabolism and a shift to the 01:13:41.440 --> 01:13:50.560 cancer metabolism producing uh uh lactic acid why do you think that the doctors do not take 01:13:50.560 --> 01:13:56.880 the 1,25 D test I mean do you think that would be more helpful to people to understanding their 01:13:56.880 --> 01:14:05.920 own vitamin D status if they'd had both 25 D and 125 D taken um yeah the really useful test is the 01:14:06.720 --> 01:14:19.280 25 the unconverted form and some doctors measure the 1,25 01:14:19.280 --> 01:14:28.480 dihydroxy and if they don't realize that that's an indicator of more of stress 01:14:29.120 --> 01:14:37.440 than a vitamin D adequacy that can be a good indicator of vitamin D deficiency when your 01:14:37.440 --> 01:14:47.760 parathyroid hormone and 1,25 dihydroxy are increased right so oh just so if you are going to like if 01:14:47.760 --> 01:14:55.120 you really wanted to understand somebody's vitamin D status what would be the labs that besides 25 D 01:14:55.120 --> 01:15:01.200 and 1,25 D that you would have been taped to get to get a really good understanding of where they're 01:15:01.200 --> 01:15:12.400 at I think the 25 hydroxy is a good enough test for almost all purposes okay so they wouldn't even 01:15:12.400 --> 01:15:20.160 need to get like parathyroid hormone basically if you're if your 25 D is low you need more vitamin D 01:15:20.160 --> 01:15:30.880 or sunlight or you need to get out of stress or a combination of all those yeah there are surgical 01:15:30.880 --> 01:15:39.520 companies websites that are adding to the confusion by saying you can't lower your 01:15:40.960 --> 01:15:52.000 parathyroid hormone but by diet or other metabolic effects you have to have your parathyroid hormone 01:15:52.000 --> 01:16:01.760 parathyroid then cut out if you have excessive parathyroid hormone but there are these forces 01:16:01.760 --> 01:16:11.200 actively misinforming the public flatly saying that you you cannot lower parathyroid hormone 01:16:11.200 --> 01:16:19.440 by eating more calcium and vitamin D but that's absolutely not true right yeah and I also saw 01:16:19.440 --> 01:16:26.000 studies that just removing phosphorus or eating a low phosphorus diet can improve parathyroid hormone 01:16:26.880 --> 01:16:37.760 yeah that is pretty well recognized as a cause of the increasing degenerative disease in the 01:16:37.760 --> 01:16:46.640 population as the high ratio of phosphate to calcium in the diet in the industrial world 01:16:46.640 --> 01:16:55.600 yeah that yes so that's most people eating a high meat grain legume nut diet and all avoiding dairy 01:16:55.600 --> 01:17:01.040 and eating their nut milk so that would be the perfect place to have low vitamin D status 01:17:01.040 --> 01:17:10.800 right right okay so I real quick I want to get back to just how vitamin D is metabolized and 01:17:10.800 --> 01:17:14.960 talking about the other co-factors the other minerals or nutrients that are involved in that 01:17:14.960 --> 01:17:21.680 certainly there's a lot of talk that if you are to take a vitamin D supplement that it will 01:17:22.400 --> 01:17:30.480 deplete or use a lot of other nutrients like vitamin A or magnesium potassium copper and so 01:17:30.480 --> 01:17:38.960 if somebody is already deficient in magnesium and copper and vitamin A would it make more sense to 01:17:38.960 --> 01:17:50.080 address those issues first before putting a D supplement in I don't think so that's actually 01:17:50.880 --> 01:17:59.680 important to work on all of them at the same time but the vitamin D itself is part of the 01:17:59.680 --> 01:18:12.480 calming anti-inflammatory process so the calcium and magnesium are essential and should be done 01:18:12.480 --> 01:18:18.880 immediately but I don't think the vitamin D supplement is going to make anything worse 01:18:20.320 --> 01:18:24.880 yeah one of the conversations is if you increase vitamin D you're going to increase kind of the 01:18:24.880 --> 01:18:29.920 burn rate of a magnesium and even vitamin A and if you're already deficient in those and since we 01:18:29.920 --> 01:18:36.240 know that vitamin A is very integrated in iron metabolism that that could actually make iron get 01:18:36.240 --> 01:18:41.760 more stored in the tissue or can dysregulate iron but also knowing that magnesium is involved in 01:18:42.400 --> 01:18:51.280 three thousand other enzymatic processes that by giving someone a lot of D and I think what you're 01:18:51.280 --> 01:18:56.480 saying is you just need to do it all together but obviously just giving someone D and not doing all 01:18:56.480 --> 01:19:06.480 the other things you could create a problem I think that idea comes largely from 50 or 60 years ago 01:19:07.840 --> 01:19:16.080 some animal experiments showed that if you give very large amounts of vitamin B1 thiamine 01:19:16.080 --> 01:19:25.840 that you you will increase the metabolic rate and for borderline deficient in others it will 01:19:25.840 --> 01:19:33.360 make the other deficiencies show up more quickly but I don't know of any experiments at all 01:19:34.080 --> 01:19:45.920 that would show that happening with vitamin D or magnesium or calcium to a great extent the body can 01:19:45.920 --> 01:19:58.240 use the boost it gets from one nutrient to reduce its need for the other nutrients 01:19:59.600 --> 01:20:09.840 such that even adding sodium or potassium can reduce your need for magnesium or calcium 01:20:09.840 --> 01:20:19.760 simply the alkaline mineral iron has a certain 01:20:22.240 --> 01:20:33.600 interactive equivalence and the vitamin A and vitamin D do work together but 01:20:33.600 --> 01:20:43.200 there you would have to be in at an extreme desperately deficient condition before you'd 01:20:43.200 --> 01:20:51.200 see one creating a deficiency of the other okay so what you're saying is even though 01:20:51.200 --> 01:20:57.280 vitamin A is needed in the vitamin D metabolism it really wouldn't matter if you started supplementing 01:20:57.280 --> 01:21:03.600 even somewhat high dose of D it wouldn't throw off your other nutrients if the other ones weren't 01:21:03.600 --> 01:21:13.760 being supported at the same time unless you were extremely deficient in them yeah yeah and vitamin 01:21:13.760 --> 01:21:21.360 A and thyroid have a noticeable interaction so that if you're on if you're borderline for thyroid 01:21:21.360 --> 01:21:31.760 function and take a huge vitamin A supplement such as a hundred thousand units you will probably 01:21:31.760 --> 01:21:43.200 experience a dip in your thyroid activity because thyroid hormone and retinol travel on the same 01:21:43.200 --> 01:21:54.320 protein and so you'll simply displace one by too much of the other but that is noticeable only in 01:21:54.320 --> 01:22:02.480 extreme situations I see um I had a thought and then it left my brain 01:22:02.480 --> 01:22:10.880 so we'll go to the next question which is should people ever take a calcium supplement 01:22:11.600 --> 01:22:25.040 or are they harmful no they should get it from food but for example eggshells or powdered oyster 01:22:25.040 --> 01:22:35.680 shells you can think of it as a food instead of throwing away the the shell of the egg 01:22:35.680 --> 01:22:48.640 why not powder it up and add it to your omelette it's uh in a in a form that is very assimilable 01:22:48.640 --> 01:22:58.400 by most people so a calcium carbonate I don't think is is a problem to use as a calcium supplement 01:22:58.400 --> 01:23:08.000 calcium supplement but some of the counter ions have their own activity so you don't want to take 01:23:08.000 --> 01:23:18.000 a very big doses of a calcium lactate or calcium gluconate for example 01:23:18.000 --> 01:23:27.760 just because that counter ion can have its own metabolic action okay so taking a food supplement 01:23:27.760 --> 01:23:31.920 like eggshell calcium which I know I I certainly recommend I know you recommend because it is 01:23:31.920 --> 01:23:38.080 actually a food that is safe to take is is there any way you should take that I've always you know 01:23:38.080 --> 01:23:44.160 read that calcium is better absorbed with sugar or also vitamin D so is it would it be smart to 01:23:44.160 --> 01:23:49.360 take that with something like orange juice or yeah yeah I think with the whole meal 01:23:51.200 --> 01:24:00.720 so you don't notice any highly purified substance tend to disturb and irritate your stomach and 01:24:00.720 --> 01:24:09.200 intestine and the calcium high concentration of calcium carbonate it can be irritating there's 01:24:09.200 --> 01:24:19.040 like too much salt or sugar in a concentrated form it's irritating to the membranes okay so anytime 01:24:19.040 --> 01:24:23.200 you're going to take a calcium supplement hopefully food source eat it with your entire 01:24:23.200 --> 01:24:29.360 meal so that you can get everything together because it can be an irritant yeah when you 01:24:29.360 --> 01:24:39.040 separate out the major nutrients the intestine is most efficient when it has the most complex 01:24:39.040 --> 01:24:47.440 mixture of of the major nutrients protein fat and carbohydrate for example if you eat only one 01:24:48.000 --> 01:24:57.760 component at a time your intestine doesn't recognize it as quite proper food and so it's 01:24:57.760 --> 01:25:06.000 not as efficient at absorbing any of the ingredients that your your intestine wants a 01:25:06.000 --> 01:25:13.520 complex natural sort of mixture of nutrients right I think there's always an argument that 01:25:13.520 --> 01:25:19.040 calcium carbonate isn't absorbed very well and would you just say if you consumed it with your 01:25:19.040 --> 01:25:24.400 complete meal and with some sugar that it would absorb much better yeah it becomes calcium 01:25:24.400 --> 01:25:32.880 chloride in the presence of stomach acid I see I see okay is there any issues with obviously you 01:25:32.880 --> 01:25:37.760 know I always think milk is a perfect food because it comes with all of the other co-factors like 01:25:37.760 --> 01:25:45.120 vitamin A and D and magnesium all the supporting agents are all together and I feel like that's 01:25:45.120 --> 01:25:50.640 you know kind of how mother nature meant it and so when you do do something like a supplement 01:25:50.640 --> 01:25:57.280 is there ever a problem to you know just how your body will take it in I've always read if you do 01:25:57.280 --> 01:26:03.040 too much calcium you're gonna lower your potassium and you'll just throw off your minerals is that 01:26:03.680 --> 01:26:11.680 is that going to happen or will your body kind of figure it out I yeah the the receptor idea 01:26:11.680 --> 01:26:20.720 leads to a lot of those worries that are unnecessary the the cells and the intestine 01:26:20.720 --> 01:26:27.920 and the body in general are very adaptive and basically intelligent about 01:26:29.040 --> 01:26:37.520 adjusting what it takes in so that it it uh isn't very easily disturbed 01:26:37.520 --> 01:26:43.760 okay right because I've heard in circles that if you ingest too much calcium at certain 01:26:43.760 --> 01:26:50.160 that somehow you can have a thyroid suppressing effect and I think it's because it was gonna 01:26:50.160 --> 01:26:56.640 lower potassium and other minerals and I and I'm hearing that that's not the case 01:26:57.840 --> 01:27:01.440 yes that started I think with some pharmaceutical 01:27:01.440 --> 01:27:09.920 experiments in which they found that taking a thyroxine supplement at the same time you take 01:27:09.920 --> 01:27:21.120 a calcium supplement ordering milk slows the absorption of the thyroxine but the a lot of 01:27:21.120 --> 01:27:27.680 pharmacists are obsessed with the idea of quick absorption but in the case of thyroid for example 01:27:28.160 --> 01:27:35.200 slow absorption is what you want and with most nutrients slow steady absorption 01:27:35.200 --> 01:27:48.320 is the best for your system to sort out and use properly okay perfect what about you know you 01:27:48.320 --> 01:27:54.240 always hear about certain ratios of minerals and one in particular that I've heard of is this 01:27:54.240 --> 01:28:00.080 calcium-magnesium ratio where you know you hear hey you need to have almost 10 times as much 01:28:00.080 --> 01:28:05.920 calcium to magnesium or and then I've also heard the reverse where the magnesium should be much 01:28:05.920 --> 01:28:11.200 higher than the calcium are you just going back to the entire back to that receptor theory that 01:28:11.200 --> 01:28:16.480 does that matter do we need to be aware of something like that or should we just eat whole 01:28:16.480 --> 01:28:28.960 foods and not worry basically yeah the body can sort out great ranges of proportion between 01:28:28.960 --> 01:28:40.000 calcium and magnesium and milk has quite a lot more calcium than magnesium but a pure milk diet 01:28:40.640 --> 01:28:47.840 you can't become magnesium deficiency because milk has more than enough magnesium 01:28:47.840 --> 01:28:58.000 if you're getting an adequate calcium supply from it okay and that kind of brings me to the next 01:28:58.000 --> 01:29:02.800 question that and then just so everybody knows we're almost to the finish line which is super 01:29:02.800 --> 01:29:09.680 exciting but I this has been so interesting um I think a lot of people get this idea this imbalance 01:29:09.680 --> 01:29:15.600 of minerals because they're using a diagnostic test like a hair mineral uh hair tissue mineral 01:29:15.600 --> 01:29:19.920 analysis tests and I think you get all these ratios on this test and say oh look you're high 01:29:19.920 --> 01:29:26.560 in calcium or you're high in this is that a good test to understand the minerals inside of us 01:29:28.240 --> 01:29:40.160 no it's a good test of what you wash your hair with okay and just being in a dusty environment 01:29:40.160 --> 01:29:47.440 or a chemically polluted environment you can tell where a person has been by smelling their hair 01:29:48.320 --> 01:29:58.720 because it it binds things so easily and it will pull things out out of the water with with a 01:29:58.720 --> 01:30:08.160 moderate amount of calcium in water uh your hair is going to bind a lot of calcium but if you have 01:30:08.160 --> 01:30:15.440 softened water with lots of sodium in it then your hair is going to experience a high sodium 01:30:16.640 --> 01:30:27.280 rather than calcium environment. Experimenters years ago compared toenails to hair and found 01:30:27.280 --> 01:30:38.800 the toenails by being constantly protected and the thicker material than hair is much more 01:30:38.800 --> 01:30:48.000 representative of your actual tissue mineral levels but still your toenails take about six months 01:30:48.000 --> 01:30:57.520 to get long enough to clip off and so the hair is is convenient and if you clip it 01:30:57.520 --> 01:31:03.520 close to your skin you can get hair that has only been exposed to the environment 01:31:04.240 --> 01:31:16.160 for several days but still just one one shampoo with hard water is going to fill your hair with 01:31:16.160 --> 01:31:22.960 calcium or magnesium. What about hair pulled it what if they pull the root would that make a 01:31:22.960 --> 01:31:34.320 difference? Yeah if you measure just the the knob on the end you would get more would it still be an 01:31:34.320 --> 01:31:40.720 accurate even like I said if you were able to use the hair that hadn't been uh altered by water or 01:31:40.720 --> 01:31:50.160 air would that hair be a good analysis of the minerals in your body? The water gets pretty far 01:31:50.160 --> 01:32:01.200 down the hair shaft so it would have to just be the very knob at the end. Is there any good test 01:32:01.200 --> 01:32:08.320 outside of ripping your toenail off that sounds a little painful of actually checking minerals in 01:32:08.320 --> 01:32:16.640 your body I mean is is blood acceptable would that give you some understanding? Yeah if you include 01:32:17.760 --> 01:32:26.160 all of the blood cells that's going to be a very accurate and repeatable representative for your 01:32:26.160 --> 01:32:32.800 mineral content. So what test would those be specifically because that's obviously not a 01:32:32.800 --> 01:32:37.520 normal test that your doctor's going to do like are you talking about the the red blood cell 01:32:38.880 --> 01:32:48.880 what's in those? A chemist would just dissolve the whole whole thing 01:32:48.880 --> 01:32:57.920 in an acid or alkali and just measure the the mineral content in an absolute sense. 01:32:57.920 --> 01:33:06.960 And you're referencing the blood though? Yeah measurable in the blood yeah okay so but if I 01:33:06.960 --> 01:33:11.920 wanted to go to my lab and then I wanted to know all of what my minerals were would it I mean because 01:33:11.920 --> 01:33:18.000 I can go get copper or magnesium or is it red blood cell magnesium or like what where what would it 01:33:18.000 --> 01:33:27.440 would it be that I would actually buy from a lab? Well if they're separating your serum and cells 01:33:27.440 --> 01:33:35.120 centrifuging it and so on then you're only going to be measuring one component 01:33:36.560 --> 01:33:44.720 of the blood and then you have to know how that component is reflecting what's in the rest of the 01:33:44.720 --> 01:33:56.000 body. So if you have a very good standard then any particular component is going to be altered 01:33:57.840 --> 01:34:06.960 according to the condition of the body but if you want to know the the general body status 01:34:06.960 --> 01:34:16.000 for minerals in general I think the whole whole blood homogenate would be the appropriate thing 01:34:16.000 --> 01:34:23.280 to measure. Okay um I had a real a question real quick and it was come in front of what does it 01:34:23.280 --> 01:34:32.320 mean if somebody has excessively low parathyroid hormones? Like I think that they are probably 01:34:32.320 --> 01:34:42.000 taking enough vitamin D and calcium and magnesium. So you're basically saying it can't really get too 01:34:42.000 --> 01:34:52.960 low like if they're lower than their norm number then you're good. Except when you surgically remove 01:34:52.960 --> 01:35:02.560 the parathyroid glands if you keep them supplied with magnesium and vitamin D 01:35:04.080 --> 01:35:14.320 they generally are remarkably healthy. Their sleep improves and remember that aging is a constant 01:35:14.320 --> 01:35:23.680 increase in parathyroid hormone and the parathyroid hormone every night rises and accelerates the 01:35:23.680 --> 01:35:33.200 aging process. So it's something that gets worse the older you are and exacerbates the problem. 01:35:34.160 --> 01:35:43.600 And so the the good benefits of parathyroidectomy in people with kidney disease for example 01:35:43.600 --> 01:35:45.520 are very impressive. 01:35:45.520 --> 01:35:55.120 So basically that is the explanation as you get old everybody when everybody but people 01:35:55.120 --> 01:36:02.000 under stress certainly you see a lot of osteopenia all osteoporosis or kidney stones starting to 01:36:02.000 --> 01:36:09.200 occur and that's just a sign that the system is under stress. Correct? I think so. Right. 01:36:09.200 --> 01:36:19.760 Real quick a question about magnesium. Where would you recommend people get a source? Would you get a 01:36:19.760 --> 01:36:26.000 food source? And obviously there's a lot of people that you know use a lot of magnesium. Is magnesium 01:36:26.000 --> 01:36:30.080 something that most people should be taking since we're all under stress and we're losing it daily? 01:36:31.520 --> 01:36:41.200 A milk is a very generous source. Coffee is a consistent source. It's a small amount but 01:36:41.200 --> 01:36:49.760 it can help as a supplement to the milk. Orange juice contributes a moderate amount of meat and 01:36:49.760 --> 01:36:57.520 fish and the high phosphate foods always contain a considerable amount of magnesium. 01:37:00.160 --> 01:37:04.320 And if people don't feel like they're getting enough should do you think they should supplement 01:37:04.320 --> 01:37:09.040 and if they they should supplement is there a preferred magnesium source that you would tell 01:37:09.040 --> 01:37:18.400 is a better source? Years and years ago I experimented with magnesium carbonate. 01:37:20.560 --> 01:37:34.240 I had used it for in Mexico as a counteraction of tourista diarrhea and I always had a little block 01:37:34.240 --> 01:37:43.120 of magnesium carbonate and a doctor friend was complaining about her horrible uterine cramps 01:37:44.080 --> 01:37:51.920 and she normally wouldn't consider a nutritional supplement but since she 01:37:51.920 --> 01:38:01.200 was pretty much immobilized by the discomfort of the cramp she was willing to take a chunk of 01:38:01.200 --> 01:38:10.480 magnesium carbonate and chew it up and in just about five minutes she looked down at her abdomen 01:38:10.480 --> 01:38:21.360 said I can't believe it they stopped completely and it can have almost instantaneous effect of 01:38:21.360 --> 01:38:30.240 working the way calcium does as a quieting influence but it can be very quick and reliable 01:38:31.040 --> 01:38:43.120 but the trouble is that many of the manufacturing methods for magnesium carbonate and other magnesium 01:38:43.120 --> 01:38:54.160 compounds they involve contaminants that can be allergenic and lots and lots of people get a 01:38:54.160 --> 01:39:07.120 headache or a squeezing allergy symptoms of a variety of types from using magnesium supplements 01:39:07.120 --> 01:39:18.320 magnesium glycinate so far I haven't heard any serious complaints from that form of it. 01:39:18.320 --> 01:39:23.680 Yeah that's that would be the one I prefer and I don't know have you ever tried the magnesium 01:39:23.680 --> 01:39:33.760 bicarbonate? I know people who use it and like it yeah yeah those seem to be I think the least harsh 01:39:33.760 --> 01:39:38.560 and the ones that people don't complain obviously magnesium carbonate I think to a lot of people 01:39:38.560 --> 01:39:43.200 acts as a good laxative so I think things start moving quickly and I don't know if it's that is 01:39:43.200 --> 01:39:46.880 that because of the carbonate or was that just because of the additives they might have in the 01:39:46.880 --> 01:39:59.200 carbonate magnesium itself at a certain level it works as laxative if it's anti-inflammatory 01:39:59.200 --> 01:40:07.680 sometimes the the bowel is being paralyzed by inflammation and so something which is 01:40:09.200 --> 01:40:21.280 antispasmodic can let the normal peristalsis take over. Gotcha well that is all the questions I have 01:40:21.280 --> 01:40:28.800 I don't know if you have anything else to add Ray that was a lot of amazing information I don't 01:40:28.800 --> 01:40:35.840 know do you think we hopefully covered most of it? Yeah I don't think of anything else. 01:40:37.200 --> 01:40:41.920 And well done in an hour and a half too I'm surprised I thought it might take like two 01:40:41.920 --> 01:40:47.040 and a half hours. Well you know what as I was going I started to realize we'd covered a lot 01:40:47.040 --> 01:40:51.600 of these other questions I was like okay we kind of covered that and I'm like all right we covered 01:40:51.600 --> 01:40:58.400 that to start now I was getting a little bit yeah yeah that was awesome. That was so so good 01:40:58.400 --> 01:41:06.000 on you know like when we did the one with Georgi and Kate and Matt and Benny I think people were 01:41:06.000 --> 01:41:13.280 just a bit confused. I think this will be much easier to understand which is good. I hope so. 01:41:13.280 --> 01:41:20.640 Awesome well thank you so much Ray I'm sure everyone will love this podcast just as much 01:41:20.640 --> 01:41:25.920 as the last one so much valuable information and thank you so much Kate for putting all those 01:41:25.920 --> 01:41:33.200 questions to get all those thorough super thorough questions. So I guess maybe just to finish off Kate 01:41:34.640 --> 01:41:43.600 so are we pro vitamin D? Well I think at the end of the day as Ray said I mean I think that if you 01:41:43.600 --> 01:41:50.000 are actually low vitamin D that it's it would be as you say it's not a harmful substance to try 01:41:50.000 --> 01:41:55.600 and I think Ray would agree I mean you have to take an excessive amount to really get a 01:41:55.600 --> 01:42:06.720 harmful effect would you agree? Yeah I've never known a person or even a study of the 25-hydroxy D 01:42:06.720 --> 01:42:19.440 causing harm like five million units continued for a period of time probably can be harmful but 01:42:19.440 --> 01:42:27.680 I've never run across anyone of people with rheumatoid arthritis when they feel a slight benefit 01:42:27.680 --> 01:42:33.600 from five or ten thousand units a day some of them have gone up to twenty thousand 01:42:33.600 --> 01:42:43.840 or more units per day and not only get complete relief but tend not to have a recurrence 01:42:45.040 --> 01:42:55.120 so the big doses are pretty consistently therapeutic and once you get the 01:42:55.120 --> 01:43:04.160 inflammation under control then you don't need to keep such high doses. Great I just had a thought 01:43:04.160 --> 01:43:09.040 because I've certainly read studies that have shown that people you know they've taken over time and I 01:43:09.040 --> 01:43:14.240 can't remember the study but it was they they gave different dosages of vitamin D's to women I think 01:43:14.240 --> 01:43:19.680 it was like 400 IUs two thousand and ten thousand IUs and then followed them for a significant amount 01:43:19.680 --> 01:43:24.960 of time and then then found at the end of this study that the ones that were taking the highest 01:43:24.960 --> 01:43:35.120 amount of D showed more bone loss than the other ones and do you have some explanation as to why 01:43:35.120 --> 01:43:45.520 that could occur? No I would have to see the details of the study and hope it wasn't done 01:43:45.520 --> 01:43:55.200 by a martial disciple. It might have been. Yeah one of the funny things in his 2017 01:43:55.760 --> 01:44:04.160 publication was he was connecting not only the restorative effective vitamin 01:44:04.160 --> 01:44:16.720 of angiotensin blocker on the vitamin D receptor but he was incriminating electro-smog 01:44:16.720 --> 01:44:23.680 which isn't a good thing but he was incriminating that as a factor in the vitamin D receptor 01:44:23.680 --> 01:44:32.240 malfunction and he recommended a silver thread cap as a way to protect the brain from the 01:44:32.240 --> 01:44:43.920 electro-smog and help your vitamin D receptor but probably there is a shielding effect from 01:44:44.960 --> 01:44:54.880 silver threads in the cap but why not the whole old-fashioned aluminum hat aluminum foil 01:44:54.880 --> 01:44:59.120 hat which is an absolute brain shield. 01:44:59.120 --> 01:45:07.920 Well maybe we'll have to get that study over because there are some out there that I sometimes 01:45:07.920 --> 01:45:11.280 wonder and I'm sure there might be something in the study that would explain it not just 01:45:11.920 --> 01:45:19.200 I didn't know so that was awesome and so yeah I think that the takeaway is if you're gonna get 01:45:19.200 --> 01:45:24.160 vitamin D get some in olive oil. Yeah we'll have a look should we have a I'll have a search 01:45:24.160 --> 01:45:27.760 see if we can find some brands because I've never really seen any brands in olive oil. 01:45:27.760 --> 01:45:33.040 They're mostly I think fine in the MCT oil and most people I know don't have an issue with that 01:45:33.040 --> 01:45:38.240 but I'm sure as you say they could. I'd certainly have had people tell me they definitely have some 01:45:38.240 --> 01:45:43.840 very strong reactions with vitamin D and they just cannot take it so it could be that MCT oil. 01:45:43.840 --> 01:45:49.280 Well we can drop the link to the Carlsen's and try and find some olive oil ones as well. 01:45:49.280 --> 01:45:56.800 Absolutely. Yeah awesome well thank you so much Dr. Peat thank you so much Kate 01:45:56.800 --> 01:46:03.200 and awesome I'm sure we'll probably think of some another awesome topic to have Ray on again. 01:46:04.000 --> 01:46:08.080 I hope so. Ray it was such a pleasure to talk to you and let me pick your brain 01:46:08.080 --> 01:46:12.080 for that long length of time I totally appreciate it and enjoy it. 01:46:12.080 --> 01:46:22.160 Yeah thank you it's fun to think about the the subject it's an area that is going to get more 01:46:22.160 --> 01:46:29.360 and more interesting as more research opens up what the vitamin D is really doing. 01:46:30.320 --> 01:46:37.840 Yeah you're welcome anytime. Great thanks so much have a great day guys or evening I should say bye. 01:46:38.320 --> 01:46:43.680 Bye. 01:46:43.680 --> 01:46:51.360 [BLANK_AUDIO]