10 Nov 2022 29 June 2023 8 Jul 2021 January 17, 2025 June 26, 2025 March 9, 2023 May 12, 2023 May 30, 2025 Contact: Stephan Schurer schurer at med dot miami dot edu Contact: Stephan Schurer stephan dot schurer at gmail dot com Contact: Stephan Schurer stephan dot schurer at med dot miami dot edu Contact: Stephan Schurer stephan dot schurer at med dot miami dot edu Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, Nicolette Ross, Joan Glenny-Pescov, Jiaming Hu, Caty Chung, Stephan Schurer* Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, Stephan Schurer* Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, add_name, Stephan Schurer* Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner,colette Ross, Joan Glenny-Pescov, Jiaming Hu, Caty Chung, Stephan Schurer* Created by: Saminda Abeyruwan, Caty Chung, Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, Nicolette Ross, Joan Glenny-Pescov, Jiaming Hu, Stephan Schurer* Created by: Caty Chung, Nicolette Ross, Joan Glenny-Pescov, Jiaming Hu, Stephan Schurer* There is a one-to-one correspondance with rdf:label value and concept descriptions. Concept description starts with the prefix BAO_. contact: Stephan Schurer: stephan dot schurer at gmail dot com created by: Uma Vempati, Hande Küçük, Ubbo Visser, Saminda Abeyruwan, Kunie Sakurai, Vance Lemmon, Stephan Schurer* BAO BioAssay Ontology Bioassay ontology bioassay ontology 2.1 2.7.2 2.7.4 2.7.5 2.8.12 2.8.15 2.8.16 2.8.2 2.8.6 An annotation property that represents an ID used in the NIH LINCS project. Oliver He, Jiangan Xie, Jie Zheng LINCS ID An annotation property that represents a PubMed BioAssay Identifier accession number. Oliver He https://pubchem.ncbi.nlm.nih.gov/help.html PubChem AID editor preferred label editor preferred term The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label example example of usage A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> IAO:0000112 uberon example_of_usage true example_of_usage example of usage example of usage has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot OBI_0000281 has curation status has curation status definition The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition. 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> DEFINITION definition textual definition definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obfoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note editor note editor note term editor Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> term editor term editor alternative term An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> alternative term alternative term definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w definition source definition source An administrative note of use for a curator but of no use for a user IAO:0000232 uberon curator_notes true curator_notes curator note curator note curator notes the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ An IRI or similar locator for a request or discussion of an ontology term. IAO:0000233 uberon external term_tracker_item true true term_tracker_item The 'tracker item' can associate a tracker with a specific ontology term. term tracker item term tracker item imported from For external terms/classes, the ontology from which the term was imported PERSON:Alan Ruttenberg PERSON:Melanie Courtot GROUP:OBI:<http://purl.obolibrary.org/obo/obi> imported from imported from IAO_0000125 Use on obsolete terms, relating the term to another term that can be used as a substitute Add as annotation triples in the granting ontology Person:Alan Ruttenberg term replaced by An association that specifies one of three data types for a particular variable, String, Code or Number. A23 Conceptual Entity Has_PCDC_Data_Type Has_PCDC_Data_Type Has_PCDC_Data_Type An association that shows which Permissible Values are possible for a specific PCDC EWS Variable concept. A29 Conceptual Entity Has_PCDC_EWS_Permissible_Value Has_PCDC_EWS_Permissible_Value Has_PCDC_EWS_Permissible_Value An association that that connects a concept representing a GDC value to any associated GDC property concept(s). A32 Conceptual Entity Is_Value_For_GDC_Property Is_Value_For_GDC_Property Is_Value_For_GDC_Property An association that shows which Permissible Values are possible for a specific PCDC GCT Variable. A34 Conceptual Entity Has_PCDC_GCT_Permissible_Value Has_PCDC_GCT_Permissible_Value Has_PCDC_GCT_Permissible_Value An association that shows which Permissible Values are possible for a specific PCDC OS Variable. A38 Conceptual Entity Has_PCDC_OS_Permissible_Value Has_PCDC_OS_Permissible_Value Has_PCDC_OS_Permissible_Value An association that shows which Permissible Values are possible for a specific PCDC HL Variable. A39 Conceptual Entity Has_PCDC_HL_Permissible_Value Has_PCDC_HL_Permissible_Value Has_PCDC_HL_Permissible_Value An association that shows which Permissible Values are possible for a specific DIPG/DMG Variable. A40 Conceptual Entity Has_DIPG_DMG_Permissible_Value Has_DIPG_DMG_Permissible_Value Has_DIPG_DMG_Permissible_Value true A property representing a concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus. NHC0 Conceptual Entity code code code A property that represents a description of the sort of thing or category to which a concept belongs in the context of the UMLS semantic network. P106 Conceptual Entity Semantic Type Semantic_Type In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS. Semantic_Type Semantic_Type A property representing an alternative Preferred Name for use in some NCI systems. P107 Conceptual Entity Display Name Display_Name Display Name Display_Name Display_Name A property representing the word or phrase that NCI uses by preference to refer to the concept. P108 Conceptual Entity Preferred Name Preferred_Name Preferred Name Preferred Term Preferred_Name Preferred_Name A property representing the concept unique identifier (CUI) assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept. P207 Conceptual Entity UMLS CUI UMLS_CUI UMLS_CUI UMLS_CUI A property representing the concept unique identifier (CUI) for those concepts that appear in NCI Metathesaurus but not in the National Library of Medicine Unified Medical Language System (NLM UMLS). P208 Conceptual Entity NCI Metathesaurus CUI NCI_META_CUI NCI_META_CUI NCI_META_CUI A property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake. P322 Conceptual Entity Contributing Source Contributing_Source Contributing_Source Contributing_Source A property representing the English language definition of a concept from a source other than NCI. P325 Conceptual Entity [source] Definition ALT_DEFINITION ALT_DEFINITION ALT_DEFINITION true A property representing a retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding. P366 Conceptual Entity Legacy Concept Name Legacy Concept Name Legacy_Concept_Name Legacy Concept Name A property representing that a term in another terminology has been mapped to a term in NCIt and describes the relationship between the mapped terms. P375 Conceptual Entity Maps_To Maps_To Maps_To A property representing notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept. P98 Conceptual Entity DesignNote DesignNote DesignNote DesignNote An alternative term used by the IEDB. IEDB alternative term tooth SubClassOf 'never in taxon' value 'Aves' x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL. PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX never_in_taxon: <http://purl.obolibrary.org/obo/RO_0002161> CONSTRUCT { in_taxon: a owl:ObjectProperty . a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . ?x rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom [ a owl:Class ; owl:complementOf ?taxon ] ] . } WHERE { ?x never_in_taxon: ?taxon . } RO:0002161 uberon never_in_taxon true true never_in_taxon never in taxon A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B. PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX part_of: <http://purl.obolibrary.org/obo/BFO_0000050> PREFIX mutually_spatially_disjoint_with: <http://purl.obolibrary.org/obo/RO_0002171> CONSTRUCT { part_of: a owl:ObjectProperty . [ a owl:Restriction ; owl:onProperty part_of: ; owl:someValuesFrom ?x ; a owl:Restriction ; owl:onProperty part_of: ; owl:someValuesFrom ?y ] ] } WHERE { ?x mutually_spatially_disjoint_with: ?y . } RO:0002171 uberon mutually_spatially_disjoint_with true true mutually_spatially_disjoint_with mutually spatially disjoint with mutually spatially disjoint with https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX present_in_taxon: <http://purl.obolibrary.org/obo/RO_0002175> CONSTRUCT { in_taxon: a owl:ObjectProperty . ?witness rdfs:label ?label . ?witness rdfs:subClassOf ?x . ?witness rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . } WHERE { ?x present_in_taxon: ?taxon . BIND(IRI(CONCAT( "http://purl.obolibrary.org/obo/RO_0002175#", MD5(STR(?x)), "-", MD5(STR(?taxon)) )) as ?witness) BIND(CONCAT(STR(?x), " in taxon ", STR(?taxon)) AS ?label) } RO:0002175 uberon present_in_taxon true true present_in_taxon The SPARQL expansion for this relation introduces new named classes into the ontology. For this reason it is likely that the expansion should only be performed during a QC pipeline; the expanded output should usually not be included in a published version of the ontology. present in taxon present in taxon 'anterior end of organism' is-opposite-of 'posterior end of organism' 'increase in temperature' is-opposite-of 'decrease in temperature' x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). RO:0002604 quality is_opposite_of true true is_opposite_of is opposite of is_opposite_of An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. UBPROP:0000001 uberon external_definition true external_definition This annotation property may be replaced with an annotation property from an external ontology such as IAO external_definition A textual description of an axiom loss in this ontology compared to an external ontology. UBPROP:0000002 uberon axiom_lost_from_external_ontology true axiom_lost_from_external_ontology This annotation property may be replaced with an annotation property from an external ontology such as IAO axiom_lost_from_external_ontology Notes on the homology status of this class. UBPROP:0000003 uberon homology_notes true homology_notes This annotation property may be replaced with an annotation property from an external ontology such as IAO homology_notes Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. UBPROP:0000007 uberon has_relational_adjective true has_relational_adjective has_relational_adjective Notes on the how instances of this class vary across species. UBPROP:0000008 uberon taxon_notes true taxon_notes taxon_notes Notes on the evolved function of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000009 uberon function_notes true function_notes function_notes Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 uberon structure_notes true structure_notes structure_notes Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 uberon development_notes true development_notes development_notes Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 uberon external_ontology_notes true external_ontology_notes external_ontology_notes FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term UBPROP:0000202 uberon fma_set_term true fma_set_term fma_set_term http://purl.org/dc/terms/contributor uberon dc-contributor true dc-contributor contributor consider created_by creation_date has_alternative_id An alternative label for a class or property which has a more general meaning than the preferred name/primary label. https://github.com/information-artifact-ontology/ontology-metadata/issues/18 has broad synonym has_broad_synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/18 disease characteristic (MONDO:0021125) has cross-reference (http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C41009"^^xsd:string An annotation property that links an ontology entity or a statement to a prefixed identifier or URI. Reference database or publication source. has cross-reference database_cross_reference An alternative label for a class or property which has the exact same meaning than the preferred name/primary label. A property representing a fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software. An alternative label for a given entity such as a commonly used abbreviation or synonym. https://github.com/information-artifact-ontology/ontology-metadata/issues/20 FULL_SYN Synonym with Source Data has exact synonym alternative_term has exact synonym has_exact_synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/20 An alternative label for a class or property which has a more specific meaning than the preferred name/primary label. https://github.com/information-artifact-ontology/ontology-metadata/issues/19 has narrow synonym has_narrow_synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/19 Name space of the ontology. disease_ontology has_obo_namespace An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct. https://github.com/information-artifact-ontology/ontology-metadata/issues/21 has related synonym has_related_synonym https://github.com/information-artifact-ontology/ontology-metadata/issues/21 An identifier for an individual entity. An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity. id An association that connects the concept defining a particular terminology subset with concepts that belong to this subset. Concept_In_Subset in subset in_subset shorthand Comment. comment Is defined by. rdfs:isDefinedBy A human readable name for this class. label label http://www.w3.org/2000/01/rdf-schema#seeAlso seeAlso spatial uberon seeAlso true seeAlso see also A skos concept mapping used to link two concepts, indicating a high degree of confidence that the concepts can be used interchangeably. has exact match A skos concept mapping used to state a hierarchical mapping link between two concepts where the DO concept is narrow (DO represents subtypes) and the xref is broad. has narrower match http://xmlns.com/foaf/0.1/depiction uberon depiction true depiction depiction has temperature unit has marker is substrate of is marker of stains has orthogonal assay design has response unit has concentration unit has perturbagen has mode of action has assay format has detection method has endpoint has measure group has assay stage has target has assay method has specification is orthogonal assay design of has assay kit has curve fit specification has percent response has concentration is perturbagen of is assay method of has inducer is regulated by has transcription factor is measure group of is related assay to Assay performed to confirm activity of compounds identified in the primary screen. It can be performed as replicate measurements at a single screening concentration or as concentration-response assay. is confirmatory assay of Counter assays typically follow concentration-response assays to confirm the biological activity of chemical entities identified in the primary assays. Counter assays eliminate active compounds that do not act on the intended target. They are performed using related targets, e.g. a receptor isoform, a homologous gene, etc which are functionally distinct from the intended target. Counter assays are also performed to eliminate cytotoxic compounds. The actives from the primary assay are tested on cultured cells and the cell death is estimated commonly by measuring ATP concentration. Other example for a counter assays a FRET assay when the primary assay used absorption readout; luminescence readout when the primary assay measured fluorescence intensity, etc. is counter assay of Same target, design, technology, format, but not necessarily the same throughput. For example primary, confirmatory, and concentration-response could be related by 'is identical to' is identical assay of is alternate assay format of is assay format of is endpoint of is regulator of is specification of has alternate assay format is target of is detection method of has manufacturer has assay control has primary assay has confirmatory assay has counter assay has summary assay has variant construct assay is variant construct assay of has parental cell line assay is parental cell line assay of has compound toxicity assay is compound toxicity assay of is primary assay of has selectivity assay is selectivity assay of has alternate target assay is alternate target assay of has alternate cell line assay is alternate cell line assay of has alternate organism assay is alternate organism assay of has alternate confirmatory assay is alternate confirmatory assay of has orthogonal assay technology is orthogonal assay technology of has alternate assay type is alternate assay type of has alternate assay conditions is alternate assay conditions of has lead optimization assay is lead optimization assay of has physicochemical profiling assay is physicochemical profiling assay of has compound fluorescence assay is compound fluorescence assay of has compound aggregation assay is compound aggregation assay of has compound redox-activity assay is compound redox-activity assay of is summary assay of has identical assay based on normalization has measured entity detects catalyzed by has cell line has form involves biological process has assay phase characteristic is indicator of has purity unit encodes is measured entity of has quality uses assay kit has assay kit component uses as substrate has time unit has substrate is binding site of tagged with has detected entity is cell line of has assay protocol is assay protocol of has associated disease is associated disease of has assay readout content has assay readout content parametricity has assay source has assay title has bioassay type is bioassay type of has assay readout type has signal direction has endpoint modifier has phenotype is phenotype of is localized in has concentration throughput has repetition throughput uses detection instrument has assay footprint silences has gene symbol is role of is unit of has unit is detected by has antibody source recombinantly expressed in has preparation method has organism has assay medium has assay serum is grown in is transfected into has role reports has binding site has function involves molecular function phenotype of c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. has function in http://www.obofoundry.org/ro/#OBO_REL:part_of part of has phenotype has part derives into See also BFO_0001009 derives from occurs in bearer of inheres in contains process X connected_to Y if and only if X and Y share a fiat boundary. connected to http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant participates in is derived from detects phenotype has indicator is described by quantifies has molecular phenotype has morphological phenotype has positive control has negative control has experimental setting has response value has temperature value has percent response value has id value has DNA sequence has ID has display info has date has purity value has concentration value has time value has concentration-point number has passage number has cell count This describes the number of repeats of an entity (e.g., artificial regulatory element, cDNA, etc.) present in a DNA construct. has copy number This describes the number of repeats of a gene of interest cloned in a DNA construct. has gene copy number This describes the number of repeats of a cDNA of interest cloned in a DNA construct. has cDNA copy number This describes the number of repeats of an artificial regulatory element present in a DNA construct. has artificial regulatory region copy number has sequence has protein sequence has nucleic acid sequence has RNA sequence has shRNA sense sequence has enzyme reaction temperature value has sense strand sequence has anti-sense strand sequence has assay deposition date A biosafety level is the level of biocontainment required to isolate hazardous biological agents in an enclosed facility. The levels of containment range from the lowest biosafety level of 1 to the highest at level 4. The levels are as follows: BSL1: Suitable for work involving well-characterized agents not known to consistently cause disease in immunocompetent adult humans, and present minimal potential hazard to laboratory personnel and the environment (definition from CDC). BSL2: Suitable for work involving agents that pose moderate hazards to personnel and the environment. It differs from BSL-1 in that 1) laboratory personnel have specific training in handling pathogenic agents and are supervised by scientists competent in handling infectious agents and associated procedures; 2) access to the laboratory is restricted when work is being conducted; and 3) all procedures in which infectious aerosols or splashes may be created are conducted in BSCs or other physical containment equipment (definition from CDC). BSL3: Suitable for clinical, diagnostic, teaching, research, or production facilities where work is performed with indigenous or exotic agents that may cause serious or potentially lethal disease through inhalation route exposure. Laboratory personnel must receive specific training in handling pathogenic and potentially lethal agents, and must be supervised by scientists competent in handling infectious agents and associated procedures. All procedures involving the manipulation of infectious materials must be conducted within BSCs, other physical containment devices, or by personnel wearing appropriate personal protective equipment (definition from CDC). BSL4: has biosafety level pH approximates the negative logarithm (base 10) of the molar concentration of dissolved hydronium ions in a solution. has assay pH value It is the force per unit area applied in a direction perpendicular to the surface of an object in an assay. has assay pressure value has cell modification temperature value has perturbagen incubation temperature value has substrate incubation temperature value It is the temperature at which the biological experiment was conducted. has assay temperature value It is the interval of time between the addition of a perturbagen, substrate or cell modification and the measurement of change, as observed by a detection method in the bioassay. has incubation time value It is the interval of time between the cell modification, namely transient transfection of plasmid DNA/ siRNA, viral transduction, etc and the measurement of change, as observed by a detection method in the bioassay. has cell modification time value has coupled substrate incubation time value It is the interval of time between the enzyme activity measurement in a kinetic assay. has enzyme reaction time value It is the interval of time between the addition of a perturbagen and the measurement of change, as observed by a detection method in the bioassay. has perturbagen incubation time value It is the interval of time between the addition of an enzyme substrate and the measurement of change, as observed by a detection/ readout in a bioassay. has substrate incubation time value has coupled substrate incubation temperature value The number of replicate measurements (repetitions) per concentration value used. has repetition point-number has wavelength value is input data value of has sequence position The nucleotide number in the sense strand of a gene that marks the beginning and end of the shRNA probe. has shRNA probe sense sequence position The nucleotide number in the sense strand of a gene that marks the beginning and end of the siRNA probe. has siRNA probe sense sequence position has ligand incubation time value The value (in conjunction with the signal direction) used to determine perturbagens of interest (hits.) Perturbagens with a readout value beyond the threshold in the direction of interest are considered active in the assay. has activity threshold value has excitation wavelength value has emission wavelength value has absorbance wavelength value has recommended name has value reports assay measurment value EC 5.4.99.7 (lanosterol synthase) inhibitor EC 5.4.99.7 (lanosterol synthase) inhibitor EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitors EC 5.4.99.* inhibitor EC 5.4.99.* inhibitors inhibitor of intramolecular transferase transferring other groups inhibitors of intramolecular transferase transferring other groups intramolecular transferase transferring other groups inhibitor intramolecular transferase transferring other groups inhibitors EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor zidovudine 3'-azido-3'-deoxythymidine AZT Azidothymidine Retrovir Zidovudin Zidovudinum zidovudine zidovudine EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitors EC 1.14.11.29 inhibitor EC 1.14.11.29 inhibitors HIF hydroxylase inhibitor HIF hydroxylase inhibitors hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors prolyl 4-hydroxylase inhibitor prolyl 4-hydroxylase inhibitors EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor EC 2.6.1.40 [(R)-3-amino-2-methylpropionate--pyruvate transaminase] inhibitor (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase inhibitor (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase inhibitors (R)-3-amino-2-methylpropionate transaminase inhibitor (R)-3-amino-2-methylpropionate transaminase inhibitors (R)-3-amino-2-methylpropionate--pyruvate aminotransferase inhibitor (R)-3-amino-2-methylpropionate--pyruvate aminotransferase inhibitors D-3-aminoisobutyrate--pyruvate aminotransferase inhibitor D-3-aminoisobutyrate--pyruvate aminotransferase inhibitors D-3-aminoisobutyrate--pyruvate transaminase inhibitor D-3-aminoisobutyrate--pyruvate transaminase inhibitors D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor D-3-aminoisobutyrate-pyruvate aminotransferase inhibitors D-3-aminoisobutyrate-pyruvate transaminase inhibitor D-3-aminoisobutyrate-pyruvate transaminase inhibitors D-AIBAT inhibitor D-AIBAT inhibitors D-beta-aminoisobutyrate:pyruvate aminotransferase inhibitor D-beta-aminoisobutyrate:pyruvate aminotransferase inhibitors EC 2.6.1.40 [(R)-3-amino-2-methylpropionate--pyruvate transaminase] inhibitors EC 2.6.1.40 inhibitor EC 2.6.1.40 inhibitors beta-aminoisobutyrate--pyruvate aminotransferase inhibitor beta-aminoisobutyrate--pyruvate aminotransferase inhibitors beta-aminoisobutyrate--pyruvate transaminase inhibitor beta-aminoisobutyrate--pyruvate transaminase inhibitors beta-aminoisobutyrate-pyruvate aminotransferase inhibitor beta-aminoisobutyrate-pyruvate aminotransferase inhibitors EC 2.6.1.40 [(R)-3-amino-2-methylpropionate--pyruvate transaminase] inhibitor EC 2.1.1.8 (histamine N-methyltransferase) inhibitor EC 2.1.1.8 (histamine N-methyltransferase) inhibitors EC 2.1.1.8 inhibitor EC 2.1.1.8 inhibitors S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitor S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitors S-adenosylmethionine-histamine N-methyltransferase inhibitor S-adenosylmethionine-histamine N-methyltransferase inhibitors histamine 1-methyltransferase inhibitor histamine 1-methyltransferase inhibitors histamine methyltransferase inhibitor histamine methyltransferase inhibitors histamine-methylating enzyme inhibitor histamine-methylating enzyme inhibitors imidazolemethyltransferase inhibitor imidazolemethyltransferase inhibitors EC 2.1.1.8 (histamine N-methyltransferase) inhibitor calmodulin antagonist calmodulin antagonist IP3 receptor antagonist D-myo-inositol 1,4,5-trisphosphate receptor antagonist D-myo-inositol 1,4,5-trisphosphate receptor antagonists IP3 antagonist IP3 antagonists IP3 receptor antagonists InsP3R antagonist InsP3R antagonists inositol trisphosphate receptor antagonist inositol trisphosphate receptor antagonists IP3 receptor antagonist adenosine A2B receptor agonist A2B agonist A2B agonists A2B receptor agonist A2B receptor agonists adenosine A2B receptor agonists adenosine A2B receptor agonist Wnt signalling activator Wnt signaling activator Wnt signaling activators Wnt signalling activators Wnt signalling activator formyl peptide receptor agonist FPR agonist FPR agonists formyl peptide receptor agonists formyl peptide receptor agonist EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor AOF2 inhibitor AOF2 inhibitors BHC110 inhibitor BHC110 inhibitors CPRF inhibitor CPRF inhibitors EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitors EC 1.14.99.66 inhibitor EC 1.14.99.66 inhibitors KDM1A inhibitor KDM1A inhibitors KIAA0601 inhibitor KIAA0601 inhibitors LSD1 inhibitor LSD1 inhibitors [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitor [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitors amine oxidase (flavin containing) domain 2 inhibitor amine oxidase (flavin containing) domain 2 inhibitors lysine (K)-specific demethylase 1A inhibitor lysine (K)-specific demethylase 1A inhibitors lysine demethylase 1A inhibitor lysine demethylase 1A inhibitors lysine-specific demethylase 1A inhibitor lysine-specific demethylase 1A inhibitors lysine-specific histone demethylase 1A inhibitor lysine-specific histone demethylase 1A inhibitors EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor hyaluronic acid synthesis inhibitor HA inhibitor HA inhibitors HA synthesis inhibitor HA synthesis inhibitors hyaluronic acid inhibitor hyaluronic acid inhibitors hyaluronic acid synthesis inhibitors hyaluronic acid synthesis inhibitor Mycoplasma genitalium metabolite Mycoplasma genitalium metabolites Mycoplasma genitalium metabolite teichoic acid biosynthesis inhibitor TarO inhibitor TarO inhibitors teichoic acid biosynthesis inhibitors teichoic acid biosynthesis inhibitor EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor DNA duplicase inhibitor DNA duplicase inhibitors DNA nucleotidyltransferase (DNA-directed) inhibitor DNA nucleotidyltransferase (DNA-directed) inhibitors DNA nucleotidyltransferase inhibitor DNA nucleotidyltransferase inhibitors DNA polymerase I inhibitor DNA polymerase I inhibitors DNA polymerase II inhibitor DNA polymerase II inhibitors DNA polymerase III inhibitor DNA polymerase III inhibitors DNA polymerase alpha inhibitor DNA polymerase alpha inhibitors DNA polymerase beta inhibitor DNA polymerase beta inhibitors DNA polymerase gamma inhibitor DNA polymerase gamma inhibitors DNA polymerase inhibitor DNA polymerase inhibitors DNA replicase inhibitor DNA replicase inhibitors DNA-dependent DNA polymerase inhibitor DNA-dependent DNA polymerase inhibitors DNA-directed DNA polymerase (EC 2.7.7.7) inhibitor DNA-directed DNA polymerase (EC 2.7.7.7) inhibitors EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitors EC 2.7.7.7 inhibitor EC 2.7.7.7 inhibitors Klenow fragment inhibitor Klenow fragment inhibitors Taq DNA polymerase inhibitor Taq DNA polymerase inhibitors Taq Pol I inhibitor Taq Pol I inhibitors Tca DNA polymerase inhibitor Tca DNA polymerase inhibitors deoxynucleate polymerase inhibitor deoxynucleate polymerase inhibitors deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) inhibitor deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) inhibitors deoxyribonucleate nucleotidyltransferase inhibitor deoxyribonucleate nucleotidyltransferase inhibitors deoxyribonucleic acid duplicase inhibitor deoxyribonucleic acid duplicase inhibitors deoxyribonucleic acid polymerase inhibitor deoxyribonucleic acid polymerase inhibitors deoxyribonucleic duplicase inhibitor deoxyribonucleic duplicase inhibitors deoxyribonucleic polymerase I inhibitor deoxyribonucleic polymerase I inhibitors deoxyribonucleic polymerase inhibitor deoxyribonucleic polymerase inhibitors duplicase inhibitor duplicase inhibitors sequenase inhibitor sequenase inhibitors EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor EC 2.7.11.20 (elongation factor 2 kinase) inhibitor ATP:[elongation factor 2] phosphotransferase inhibitor ATP:[elongation factor 2] phosphotransferase inhibitors Ca/CaM-kinase III inhibitor Ca/CaM-kinase III inhibitors CaM kinase III inhibitor CaM kinase III inhibitors EC 2.7.11.20 (elongation factor 2 kinase) inhibitors EC 2.7.11.20 inhibitor EC 2.7.11.20 inhibitors EF2K inhibitor EF2K inhibitors STK19 inhibitor STK19 inhibitors calmodulin-dependent protein kinase III inhibitor calmodulin-dependent protein kinase III inhibitors eEF2 kinase inhibitor eEF2 kinase inhibitors eEF2K inhibitor eEF2K inhibitors elongation factor 2 kinase (EC 2.7.11.20) inhibitor elongation factor 2 kinase (EC 2.7.11.20) inhibitors elongation factor 2 kinase inhibitor elongation factor 2 kinase inhibitors EC 2.7.11.20 (elongation factor 2 kinase) inhibitor EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor ATP phosphohydrolase (channel-conductance-controlling) inhibitor ATP phosphohydrolase (channel-conductance-controlling) inhibitors CFTR inhibitor CFTR inhibitors EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitors EC 3.6.3.49 inhibitor EC 3.6.3.49 inhibitors channel-conductance-controlling ATPase (EC 3.6.3.49) inhibitor channel-conductance-controlling ATPase (EC 3.6.3.49) inhibitors channel-conductance-controlling ATPase inhibitor channel-conductance-controlling ATPase inhibitors cystic fibrosis conductance regulator inhibitor cystic fibrosis conductance regulator inhibitors cystic fibrosis transmembrane conductance regulator inhibitor cystic fibrosis transmembrane conductance regulator inhibitors cystic-fibrosis membrane-conductance-regulating protein inhibitor cystic-fibrosis membrane-conductance-regulating protein inhibitors EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor dopamine receptor D2 antagonist D2 receptor antagonist D2R antagonist dopamine receptor D2 antagonist RUNX1 inhibitor AML1 inhibitor AML1 inhibitors CBFA2 inhibitor CBFA2 inhibitors RUNX1 inhibitors acute myeloid leukemia 1 protein inhibitor acute myeloid leukemia 1 protein inhibitors core-binding factor subunit alpha-2 inhibitor core-binding factor subunit alpha-2 inhibitors core-binding factor subunit alpha2 inhibitor core-binding factor subunit alpha2 inhibitors runt-related transcription factor 1 inhibitor runt-related transcription factor 1 inhibitors RUNX1 inhibitor melatonin receptor antagonist melatonin receptor antagonists melatonin receptor antagonist HIV-1 Tat inhibitor HIV-1 Tat antagonist HIV-1 Tat antagonists HIV-1 Tat inhibitors HIV-1 trans-activator of transcription antagonist HIV-1 trans-activator of transcription antagonists human immunodeficiency virus type 1 Tat antagonist human immunodeficiency virus type 1 Tat antagonists human immunodeficiency virus type 1 Tat inhibitor human immunodeficiency virus type 1 Tat inhibitors human immunodeficiency virus type 1 trans-activator of transcription antagonist human immunodeficiency virus type 1 trans-activator of transcription antagonists HIV-1 Tat inhibitor EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor ATP:caldesmon O-phosphotransferase inhibitor ATP:caldesmon O-phosphotransferase inhibitors ATP:protein phosphotransferase ((2+)/calmodulin-dependent) inhibitor ATP:protein phosphotransferase ((2+)/calmodulin-dependent) inhibitors CAM PKII inhibitor CAM PKII inhibitors Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase inhibitor Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase inhibitors Ca(2+)/calmodulin-dependent protein kinase (EC 2.7.11.17) inhibitor Ca(2+)/calmodulin-dependent protein kinase (EC 2.7.11.17) inhibitors Ca(2+)/calmodulin-dependent protein kinase 1 inhibitor Ca(2+)/calmodulin-dependent protein kinase 1 inhibitors Ca(2+)/calmodulin-dependent protein kinase II inhibitor Ca(2+)/calmodulin-dependent protein kinase II inhibitors Ca(2+)/calmodulin-dependent protein kinase IV inhibitor Ca(2+)/calmodulin-dependent protein kinase IV inhibitors Ca(2+)/calmodulin-dependent protein kinase inhibitor Ca(2+)/calmodulin-dependent protein kinase inhibitors Ca(2+)/calmodulin-dependent protein kinase kinase beta inhibitor Ca(2+)/calmodulin-dependent protein kinase kinase beta inhibitors Ca(2+)/calmodulin-dependent protein kinase kinase inhibitor Ca(2+)/calmodulin-dependent protein kinase kinase inhibitors CaM kinase II inhibitor CaM kinase II inhibitors CaM kinase inhibitor CaM kinase inhibitors CaM-regulated serine/threonine kinase inhibitor CaM-regulated serine/threonine kinase inhibitors CaMKI inhibitor CaMKI inhibitors CaMKII inhibitor CaMKII inhibitors CaMKIV inhibitor CaMKIV inhibitors CaMKKalpha inhibitor CaMKKalpha inhibitors CaMKKbeta inhibitor CaMKKbeta inhibitors EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitors EC 2.7.11.17 inhibitor EC 2.7.11.17 inhibitors STK20 inhibitor STK20 inhibitors caldesmon kinase (phosphorylating) inhibitor caldesmon kinase (phosphorylating) inhibitors caldesmon kinase inhibitor caldesmon kinase inhibitors calmodulin-dependent kinase II inhibitor calmodulin-dependent kinase II inhibitors microtubule-associated protein 2 kinase inhibitor microtubule-associated protein 2 kinase inhibitors EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor dopamine receptor D1 agonist D1 agonist D1 agonists dopamine D1 receptor agonist dopamine D1 receptor agonists dopamine receptor D1 agonists dopamine receptor D1 agonist SMO receptor agonist SMO receptor agonists smoothened agonist smoothened agonists smoothened receptor agonist smoothened receptor agonists SMO receptor agonist EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) inhibitor 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) inhibitors BBOX inhibitor BBOX inhibitors EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitors EC 1.14.11.1 inhibitor EC 1.14.11.1 inhibitors alpha-butyrobetaine hydroxylase inhibitor alpha-butyrobetaine hydroxylase inhibitors butyrobetaine hydroxylase inhibitor butyrobetaine hydroxylase inhibitors gamma-butyrobetaine hydroxylase inhibitor gamma-butyrobetaine hydroxylase inhibitors EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor hydrogen acceptor A hydrogen acceptor EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitors EC 1.13.11.11 inhibitor EC 1.13.11.11 inhibitors L-tryptophan 2,3-dioxygenase inhibitor L-tryptophan 2,3-dioxygenase inhibitors L-tryptophan pyrrolase inhibitor L-tryptophan pyrrolase inhibitors L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitor L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitors L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) inhibitor L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) inhibitors TDO inhibitor TDO inhibitors indolamine 2,3-dioxygenase inhibitor indolamine 2,3-dioxygenase inhibitors indoleamine 2,3-dioxygenase inhibitor indoleamine 2,3-dioxygenase inhibitors tryptamin 2,3-dioxygenase inhibitor tryptamin 2,3-dioxygenase inhibitors tryptamine 2,3-dioxygenase inhibitor tryptamine 2,3-dioxygenase inhibitors tryptophan 2,3-dioxygenase (EC 1.13.11.11) inhibitor tryptophan 2,3-dioxygenase (EC 1.13.11.11) inhibitors tryptophan 2,3-dioxygenase inhibitor tryptophan 2,3-dioxygenase inhibitors tryptophan oxygenase inhibitor tryptophan oxygenase inhibitors tryptophan peroxidase inhibitor tryptophan peroxidase inhibitors tryptophan pyrrolase inhibitor tryptophan pyrrolase inhibitors tryptophanase inhibitor tryptophanase inhibitors EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor herbicide safener herbicide safeners herbicide safener EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitors EC 1.14.11.2 inhibitor EC 1.14.11.2 inhibitors collagen proline hydroxylase inhibitor collagen proline hydroxylase inhibitors hydroxylase, collagen proline inhibitor hydroxylase, collagen proline inhibitors peptidyl proline hydroxylase inhibitor peptidyl proline hydroxylase inhibitors procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors procollagen-proline 4-dioxygenase inhibitor procollagen-proline 4-dioxygenase inhibitors procollagen-proline dioxygenase (EC 1.14.11.2) inhibitor procollagen-proline dioxygenase (EC 1.14.11.2) inhibitors procollagen-proline dioxygenase inhibitor procollagen-proline dioxygenase inhibitors procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitor procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitors proline hydroxylase inhibitor proline hydroxylase inhibitors proline protocollagen hydroxylase inhibitor proline protocollagen hydroxylase inhibitors proline, 2-oxoglutarate dioxygenase inhibitor proline, 2-oxoglutarate dioxygenase inhibitors proline,2-oxoglutarate 4-dioxygenase inhibitor proline,2-oxoglutarate 4-dioxygenase inhibitors prolyl 4-hydroxylase inhibitor prolyl 4-hydroxylase inhibitors prolyl hydroxylase inhibitor prolyl hydroxylase inhibitors prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitor prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitors prolylprotocollagen dioxygenase inhibitor prolylprotocollagen dioxygenase inhibitors prolylprotocollagen hydroxylase inhibitor prolylprotocollagen hydroxylase inhibitors protocollagen hydroxylase inhibitor protocollagen hydroxylase inhibitors protocollagen proline 4-hydroxylase inhibitor protocollagen proline 4-hydroxylase inhibitors protocollagen proline dioxygenase inhibitor protocollagen proline dioxygenase inhibitors protocollagen proline hydroxylase inhibitor protocollagen proline hydroxylase inhibitors protocollagen prolyl hydroxylase inhibitor protocollagen prolyl hydroxylase inhibitors EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor EC 3.2.1.23 (beta-galactosidase) inhibitor EC 3.2.1.23 (beta-galactosidase) inhibitors EC 3.2.1.23 inhibitor EC 3.2.1.23 inhibitors S 2107 inhibitor S 2107 inhibitors beta-D-galactanase inhibitor beta-D-galactanase inhibitors beta-D-galactoside galactohydrolase inhibitor beta-D-galactoside galactohydrolase inhibitors beta-D-lactosidase inhibitor beta-D-lactosidase inhibitors beta-lactosidase inhibitor beta-lactosidase inhibitors exo-(1->4)-beta-D-galactanase inhibitor exo-(1->4)-beta-D-galactanase inhibitors hydrolact inhibitor hydrolact inhibitors lactase inhibitor lactase inhibitors lactozym inhibitor lactozym inhibitors maxilact inhibitor maxilact inhibitors oryzatym inhibitor oryzatym inhibitors sumiklat inhibitor sumiklat inhibitors trilactase inhibitor trilactase inhibitors EC 3.2.1.23 (beta-galactosidase) inhibitor TRPM4 channel inhibitor TRPM4 channel inhibitors Transient receptor potential cation channel subfamily M member 4 inhibitor Transient receptor potential cation channel subfamily M member 4 inhibitors melastatin 4 inhibitor melastatin 4 inhibitors TRPM4 channel inhibitor xenoantigen xenoantigens xenoantigen bleaching agent bleaching agent EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitors EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor EC 3.6.5.5 (dynamin GTPase) inhibitor EC 3.6.5.5 (dynamin GTPase) inhibitors EC 3.6.5.5 inhibitor EC 3.6.5.5 inhibitors GTP phosphohydrolase (vesicle-releasing) inhibitor GTP phosphohydrolase (vesicle-releasing) inhibitors dynamin GTPase (EC 3.6.5.5) inhibitor dynamin GTPase (EC 3.6.5.5) inhibitors dynamin GTPase inhibitor dynamin GTPase inhibitors EC 3.6.5.5 (dynamin GTPase) inhibitor farnesoid X receptor agonist BAR agonist BAR agonists FXR agonist FXR agonists bile acid receptor agonist bile acid receptor agonists farnesoid X receptor agonists farnesoid X receptor agonist radiosensitizing agent radiosensitiser radiosensitisers radiosensitising agent radiosensitising agents radiosensitizer radiosensitizers radiosensitizing agents radiosensitizing agent 5-hydroxytryptamine 2A receptor inverse agonist 5-hydroxytryptamine (2A) receptor inverse agonist 5-hydroxytryptamine (2A) receptor inverse agonists 5-hydroxytryptamine 2A receptor inverse agonists 5HT(2A) inverse agonist 5HT(2A) inverse agonists 5HT2A inverse agonists 5HT2Ainverse agonist 5-hydroxytryptamine 2A receptor inverse agonist B-cell lymphoma 2 inhibitor B-cell lymphoma 2 inhibitors Bcl-2 inhibitor Bcl-2 inhibitors B-cell lymphoma 2 inhibitor lymphocyte function-associated antigen-1 antagonist LFA-1 antagonist LFA-1 antagonists lymphocyte function-associated antigen-1 antagonists lymphocyte function-associated antigen-1 antagonist chemical hybridisation agent chemical hybridisation agents chemical hybridization agent chemical hybridization agents chemical hybridisation agent fatty acid oxidation inhibitor fatty acid oxidation inhibitors fatty acid oxidation inhibitor EC 2.4.1.17 (glucuronosyltransferase) inhibitor 1-naphthol glucuronyltransferase inhibitor 1-naphthol glucuronyltransferase inhibitors 1-naphthol-UDP-glucuronosyltransferase inhibitor 1-naphthol-UDP-glucuronosyltransferase inhibitors 17-OH steroid UDPGT inhibitor 17-OH steroid UDPGT inhibitors 17beta-hydroxysteroid UDP-glucuronosyltransferase inhibitor 17beta-hydroxysteroid UDP-glucuronosyltransferase inhibitors 3-OH androgenic UDPGT inhibitor 3-OH androgenic UDPGT inhibitors 3alpha-hydroxysteroid UDP-glucuronosyltransferase inhibitor 3alpha-hydroxysteroid UDP-glucuronosyltransferase inhibitors 4-hydroxybiphenyl UDP-glucuronosyltransferase inhibitor 4-hydroxybiphenyl UDP-glucuronosyltransferase inhibitors EC 2.4.1.17 (glucuronosyltransferase) inhibitors EC 2.4.1.17 inhibitor EC 2.4.1.17 inhibitors UDP glucuronic acid transferase inhibitors UDP glucuronosyltransferase inhibitor UDP glucuronosyltransferase inhibitors UDP glucuronyltransferase inhibitor UDP glucuronyltransferase inhibitors UDP-alpha-D-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific; conformation-inverting) inhibitor UDP-alpha-D-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific; conformation-inverting) inhibitors UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) inhibitor UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) inhibitors UDP-glucuronyltransferase inhibitor UDP-glucuronyltransferase inhibitors UDPGA transferase inhibitor UDPGA transferase inhibitors UDPGA-glucuronyltransferase inhibitor UDPGA-glucuronyltransferase inhibitors UDPGT inhibitor UDPGT inhibitors glucuronosyltransferase inhibitor glucuronosyltransferase inhibitors uridine 5'-diphosphoglucuronyltransferase inhibitor uridine 5'-diphosphoglucuronyltransferase inhibitors uridine diphosphate glucuronyltransferase inhibitor uridine diphosphate glucuronyltransferase inhibitors uridine diphosphoglucuronosyltransferase inhibitor uridine diphosphoglucuronosyltransferase inhibitors uridine diphosphoglucuronyltransferase inhibitor uridine diphosphoglucuronyltransferase inhibitors EC 2.4.1.17 (glucuronosyltransferase) inhibitor neuropeptide Y receptor antagonist neuropeptide Y receptor antagonists neuropeptide Y receptor antagonist salt-inducible kinase 2 inhibitor SIK2 inhibitor SIK2 inhibitors SNF1LK2 inhibitor SNF1LK2 inhibitors salt-inducible kinase 2 inhibitors serine/threonine-protein kinase SIK2 inhibitor salt-inducible kinase 2 inhibitor EC 2.5.1.46 (deoxyhypusine synthase) inhibitor (4-aminobutyl)lysine synthase inhibitor (4-aminobutyl)lysine synthase inhibitors DHS inhibitor DHS inhibitors EC 2.5.1.46 (deoxyhypusine synthase) inhibitors EC 2.5.1.46 inhibitor EC 2.5.1.46 inhibitors [eIF-5A]-deoxyhypusine synthase inhibitor [eIF-5A]-deoxyhypusine synthase inhibitors [eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitor [eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitors spermidine dehydrogenase inhibitor spermidine dehydrogenase inhibitors spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitor spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitors EC 2.5.1.46 (deoxyhypusine synthase) inhibitor hypoxia-inducible factor pathway activator HIF pathway activator HIF pathway activators hypoxia activator hypoxia activators hypoxia-inducible factor pathway activators hypoxia-inducible factor pathway activator EC 1.15.1.1 (superoxide dismutase) inhibitor EC 1.15.1.1 (superoxide dismutase) inhibitor lipopolysaccharide biosynthesis inhibitor lipopolysaccharide biosynthesis inhibitors lipopolysaccharide biosynthesis inhibitor EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitors EC 3.5.1.108 inhibitor EC 3.5.1.108 inhibitors LpxC deacetylase inhibitor LpxC deacetylase inhibitors LpxC enzyme inhibitor LpxC enzyme inhibitors LpxC inhibitor LpxC inhibitors UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase inhibitor UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase inhibitors UDP-(3-O-acyl)-N-acetylglucosamine deacetylase inhibitor UDP-(3-O-acyl)-N-acetylglucosamine deacetylase inhibitors UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitor UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitors UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitors UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine amidohydrolase inhibitor UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine amidohydrolase inhibitors UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase inhibitor UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase inhibitors UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase inhibitor UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase inhibitors UDP-3-O-acyl-GlcNAc deacetylase inhibitor UDP-3-O-acyl-GlcNAc deacetylase inhibitors deacetylase LpxC inhibitor deacetylase LpxC inhibitors EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor antidote to barbiturate poisoning antidote to barbiturate overdose antidote to barbiturate poisoning platelet-activating factor receptor antagonist PAF antagonist PAF antagonists platelet-activating factor receptor antagonists platelet-activating factor receptor antagonist EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor E3 component of alpha-ketoacid dehydrogenase complexes inhibitor E3 component of alpha-ketoacid dehydrogenase complexes inhibitors EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitors EC 1.8.1.4 inhibitor EC 1.8.1.4 inhibitors L-protein inhibitor L-protein inhibitors LDP-Glc inhibitor LDP-Glc inhibitors LDP-Val inhibitor LDP-Val inhibitors dehydrolipoate dehydrogenase inhibitor dehydrolipoate dehydrogenase inhibitors diaphorase inhibitor diaphorase inhibitors dihydrolipoamide dehydrogenase inhibitor dihydrolipoamide dehydrogenase inhibitors dihydrolipoamide:NAD(+) oxidoreductase inhibitor dihydrolipoamide:NAD(+) oxidoreductase inhibitors dihydrolipoic dehydrogenase inhibitor dihydrolipoic dehydrogenase inhibitors dihydrothioctic dehydrogenase inhibitor dihydrothioctic dehydrogenase inhibitors glycine-cleavage system L-protein inhibitor glycine-cleavage system L-protein inhibitors lipoamide dehydrogenase (NADH) inhibitor lipoamide dehydrogenase (NADH) inhibitors lipoamide oxidoreductase (NADH) inhibitor lipoamide oxidoreductase (NADH) inhibitors lipoamide reductase (NADH) inhibitor lipoamide reductase (NADH) inhibitors lipoamide reductase inhibitor lipoamide reductase inhibitors lipoate dehydrogenase inhibitor lipoate dehydrogenase inhibitors lipoic acid dehydrogenase inhibitor lipoic acid dehydrogenase inhibitors lipoyl dehydrogenase inhibitor lipoyl dehydrogenase inhibitors protein-6-N-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitor protein-6-N-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitors protein-N(6)-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitor protein-N(6)-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitors EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitor 6-hydroxypurine phosphoribosyltransferase inhibitor 6-mercaptopurine phosphoribosyltransferase inhibitor EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitors EC 2.4.2.8 inhibitor EC 2.4.2.8 inhibitors GMP pyrophosphorylase inhibitor GPRT inhibitor HGPRTase inhibitor HPRT inhibitor IMP pyrophosphorylase inhibitor IMP-GMP pyrophosphorylase inhibitor IMP:diphosphate phospho-D-ribosyltransferase inhibitor guanine phosphoribosyltransferase inhibitor guanine-hypoxanthine phosphoribosyltransferase inhibitor guanosine 5'-phosphate pyrophosphorylase inhibitor guanosine phosphoribosyltransferase inhibitor guanylate pyrophosphorylase inhibitor guanylic pyrophosphorylase inhibitor hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) inhibitor hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) inhibitors hypoxanthine phosphoribosyltransferase inhibitor hypoxanthine phosphoribosyltransferase inhibitors hypoxanthine-guanine phosphoribosyltransferase inhibitor inosinate pyrophosphorylase inhibitor inosine 5'-phosphate pyrophosphorylas inhibitore inosinic acid pyrophosphorylase inhibitor inosinic pyrophosphorylase inhibitor purine-6-thiol phosphoribosyltransferase inhibitor transphosphoribosidase inhibitor EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitor EC 1.11.1.7 (peroxidase) inhibitor Arthromyces ramosus peroxidase inhibitor Arthromyces ramosus peroxidase inhibitors Coprinus cinereus peroxidase inhibitor Coprinus cinereus peroxidase inhibitors EC 1.11.1.7 (peroxidase) inhibitors EC 1.11.1.7 inhibitor EC 1.11.1.7 inhibitors HRP inhibitor HRP inhibitors Japanese radish peroxidase inhibitor Japanese radish peroxidase inhibitors extensin peroxidase inhibitor extensin peroxidase inhibitors guaiacol peroxidase inhibitor guaiacol peroxidase inhibitors heme peroxidase inhibitor heme peroxidase inhibitors horseradish peroxidase (HRP) inhibitor horseradish peroxidase (HRP) inhibitors horseradish peroxidase inhibitor horseradish peroxidase inhibitors lactoperoxidase inhibitor lactoperoxidase inhibitors oxyperoxidase inhibitor oxyperoxidase inhibitors peroxidase (EC 1.11.1.7) inhibitor peroxidase (EC 1.11.1.7) inhibitors peroxidase inhibitor peroxidase inhibitors phenolic donor:hydrogen-peroxide oxidoreductase inhibitor phenolic donor:hydrogen-peroxide oxidoreductase inhibitors plant peroxidase inhibitor plant peroxidase inhibitors protoheme peroxidase inhibitor protoheme peroxidase inhibitors pyrocatechol peroxidase inhibitor pyrocatechol peroxidase inhibitors scopoletin peroxidase inhibitor scopoletin peroxidase inhibitors soybean peroxidase (SBP) inhibitor soybean peroxidase (SBP) inhibitors EC 1.11.1.7 (peroxidase) inhibitor LRH-1 antagonist LRH-1 antagonists NR5A2 antagonist NR5A2 antagonists liver receptor homolog-1 antagonist liver receptor homolog-1 antagonists liver receptor homologue-1 antagonist liver receptor homologue-1 antagonists nuclear receptor subfamily 5 group A member 2 antagonist nuclear receptor subfamily 5 group A member 2 antagonists LRH-1 antagonist propesticide pro-pesticide pro-pesticides propesticides propesticide proinsecticide pro-insecticide pro-insecticides proinsecticides proinsecticide profungicide pro-fungicide pro-fungicides profungicides profungicide proherbicide pro-herbicide pro-herbicides proherbicides proherbicide proacaricide pro-acaricide pro-acaricides proacaricides proacaricide prosafener pro-safener pro-safeners prosafeners prosafener S100 calcium-binding protein B inhibitor S100 calcium-binding protein B inhibitors S100B inhibitor S100B inhibitors S100 calcium-binding protein B inhibitor pro-agent pro-agents proagent proagents pro-agent antidote to sarin poisoning antidote to sarin poisoning EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitor 1-aminocyclopropane-1-carboxylate synthase inhibitor 1-aminocyclopropane-1-carboxylate synthase inhibitors 1-aminocyclopropane-1-carboxylate synthetase inhibitor 1-aminocyclopropane-1-carboxylate synthetase inhibitors 1-aminocyclopropane-1-carboxylic acid synthase inhibitor 1-aminocyclopropane-1-carboxylic acid synthase inhibitors 1-aminocyclopropanecarboxylate synthase inhibitor 1-aminocyclopropanecarboxylate synthase inhibitors ACC synthase inhibitor ACC synthase inhibitors EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitors EC 4.4.1.14 inhibitor EC 4.4.1.14 inhibitors S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming) inhibitor S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming) inhibitors S-adenosyl-L-methionine methylthioadenosine-lyase inhibitor S-adenosyl-L-methionine methylthioadenosine-lyase inhibitors aminocyclopropanecarboxylate synthase inhibitor aminocyclopropanecarboxylate synthase inhibitors aminocyclopropanecarboxylic acid synthase inhibitor aminocyclopropanecarboxylic acid synthase inhibitors EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitor eukaryotic initiation factor 4F inhibitor eIF4F inhibitor eIF4F inhibitors eukaryotic initiation factor 4F inhibitors eukaryotic initiation factor 4F inhibitor bromodomain-containing protein 4 inhibitor BRD4 inhibitor BRD4 inhibitors bromodomain-containing protein 4 inhibitors bromodomain-containing protein 4 inhibitor EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor ATP:[receptor-protein] phosphotransferase inhibitor ATP:[receptor-protein] phosphotransferase inhibitors EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitors EC 2.7.11.30 inhibitor EC 2.7.11.30 inhibitors STK13 inhibitor STK13 inhibitors TGF-beta kinase inhibitor TGF-beta kinase inhibitors activin receptor kinase inhibitor activin receptor kinase inhibitors inhibitor of receptor protein serine/threonine kinase receptor protein serine/threonine kinase (EC 2.7.11.30) inhibitor receptor protein serine/threonine kinase (EC 2.7.11.30) inhibitors receptor protein serine/threonine kinase inhibitor receptor protein serine/threonine kinase inhibitors receptor serine/threonine protein kinase inhibitor receptor serine/threonine protein kinase inhibitors receptor type I serine/threonine protein kinase inhibitor receptor type I serine/threonine protein kinase inhibitors receptor type II serine/threonine protein kinase inhibitor receptor type II serine/threonine protein kinase inhibitors EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor capsaicin receptor agonist TRPV1 agonist TRPV1 agonists capsaicin agonist capsaicin agonists capsaicin receptor agonists transient receptor potential cation channel subfamily V member 1 agonist transient receptor potential cation channel subfamily V member 1 agonists vanilloid receptor 1 agonist vanilloid receptor 1 agonists capsaicin receptor agonist antihypotensive agent antihypotensive agents pressor pressors vasopressor agent vasopressor agents antihypotensive agent TRPA1 channel agonist TRPA1 channel agonists transient receptor potential ankyrin 1 agonist transient receptor potential ankyrin 1 agonists transient receptor potential cation channel A1 agonist transient receptor potential cation channel A1 agonists TRPA1 channel agonist EC 2.5.1.48 (cystathionine gamma-synthase) inhibitor 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitor 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitors EC 2.5.1.48 (cystathionine gamma-synthase) inhibitors EC 2.5.1.48 inhibitor EC 2.5.1.48 inhibitors O(4)-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitor O(4)-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitors O-succinyl-L-homoserine succinate-lyase (adding cysteine) inhibitor O-succinyl-L-homoserine succinate-lyase (adding cysteine) inhibitors O-succinylhomoserine (thiol)-lyase inhibitor O-succinylhomoserine (thiol)-lyase inhibitors O-succinylhomoserine synthase inhibitor O-succinylhomoserine synthase inhibitors O-succinylhomoserine synthetase inhibitor O-succinylhomoserine synthetase inhibitors cystathionine gamma-synthase inhibitor cystathionine gamma-synthase inhibitors cystathionine synthase inhibitor cystathionine synthase inhibitors cystathionine synthetase inhibitor cystathionine synthetase inhibitors homoserine O-transsuccinylase inhibitor homoserine O-transsuccinylase inhibitors homoserine transsuccinylase inhibitor homoserine transsuccinylase inhibitors EC 2.5.1.48 (cystathionine gamma-synthase) inhibitor EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor 11beta-hydroxy steroid dehydrogenase inhibitor 11beta-hydroxy steroid dehydrogenase inhibitors 11beta-hydroxysteroid dehydrogenase inhibitor 11beta-hydroxysteroid dehydrogenase inhibitors 11beta-hydroxysteroid dehydrogenase type 1 inhibitor 11beta-hydroxysteroid dehydrogenase type 1 inhibitors 11beta-hydroxysteroid:NADP(+) 11-oxidoreductase inhibitor 11beta-hydroxysteroid:NADP(+) 11-oxidoreductase inhibitors EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitors EC 1.1.1.146 inhibitor EC 1.1.1.146 inhibitors beta-hydroxysteroid dehydrogenase inhibitor beta-hydroxysteroid dehydrogenase inhibitors corticosteroid 11-reductase inhibitor corticosteroid 11-reductase inhibitors corticosteroid 11beta-dehydrogenase inhibitor corticosteroid 11beta-dehydrogenase inhibitors dehydrogenase, 11beta-hydroxy steroid inhibitor dehydrogenase, 11beta-hydroxy steroid inhibitors EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor Papio hamadryas metabolite P. hamadryas metabolite P. hamadryas metabolites Papio hamadryas metabolites Papio hamadryas metabolite anxiogenic anxiogenics panicogenic panicogenics anxiogenic EC 3.4.22.56 (caspase-3) inhibitor CASP-3 inhibitor CASP-3 inhibitors CPP32 inhibitor CPP32 inhibitors EC 3.4.22.56 (caspase-3) inhibitors EC 3.4.22.56 inhibitor EC 3.4.22.56 inhibitors apopain inhibitor apopain inhibitors caspase-3 (EC 3.4.22.56) inhibitor caspase-3 (EC 3.4.22.56) inhibitors caspase-3 inhibitor caspase-3 inhibitors yama protein inhibitor yama protein inhibitors EC 3.4.22.56 (caspase-3) inhibitor endocrine disruptor endocrine disrupting chemical endocrine disrupting chemicals endocrine disrupting compound endocrine disrupting compounds endocrine disruptors endocrine-disrupting chemical endocrine-disrupting chemicals hormonally active agent hormonally active agents endocrine disruptor ATPase motor cytoplasmic dynein inhibitor ATPase motor cytoplasmic dynein inhibitors ATPase motor cytoplasmic dynein inhibitor inorganic acid inorganic acids mineral acid mineral acids inorganic acid neuropeptide Y2 receptor agonist neuropeptide Y2 receptor agonist carotenoid biosynthesis inhibitor carotenogenesis inhibitor carotenogenesis inhibitors carotenoid biosynthesis inhibitors carotenoid-biosynthesis inhibitor carotenoid-biosynthesis inhibitors carotenoid biosynthesis inhibitor RhoA inhibitor Ras homolog gene family, member A inhibitor Ras homolog gene family, member A inhibitors RhoA GTPase inhibitor RhoA GTPase inhibitors RhoA inhibitors RhoA inhibitor RhoC inhibitor Ras homolog gene family, member C inhibitor Ras homolog gene family, member C inhibitors RhoC GTPase inhibitor RhoC GTPase inhibitors RhoC inhibitors RhoC inhibitor EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor 7alpha-HSDH inhibitor 7alpha-HSDH inhibitors 7alpha-hydroxy steroid dehydrogenase inhibitor 7alpha-hydroxy steroid dehydrogenase inhibitors 7alpha-hydroxysteroid dehydrogenase inhibitor 7alpha-hydroxysteroid dehydrogenase inhibitors 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase inhibitor 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase inhibitors EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitors EC 1.1.1.159 inhibitor EC 1.1.1.159 inhibitors EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor angiotensin receptor agonist angiotensin receptor agonists angiotensin receptor agonist autophagy inducer autophagocytosis inducer autophagocytosis inducers autophagy inducers autophagy inducer prostaglandin receptor antagonist prostaglandin receptor antagonists prostanoid receptor antagonist prostanoid receptor antagonists prostaglandin receptor antagonist EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitors EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor CAD inhibitor CAD inhibitors CPS inhibitor CPS inhibitors EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitors EC 6.3.5.5 inhibitor EC 6.3.5.5 inhibitors GD-CPSase inhibitor GD-CPSase inhibitors HCO3(-):L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitor HCO3(-):L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitors carA inhibitor carA inhibitors carB inhibitor carB inhibitors carbamoyl phosphate synthetase inhibitor carbamoyl phosphate synthetase inhibitors carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) inhibitor carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) inhibitors carbamoyl-phosphate synthetase (glutamine-hydrolysing) inhibitor carbamoyl-phosphate synthetase (glutamine-hydrolysing) inhibitors carbamoylphosphate synthetase II inhibitor carbamoylphosphate synthetase II inhibitors carbamyl phosphate synthetase (glutamine) inhibitor carbamyl phosphate synthetase (glutamine) inhibitors carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitor carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitors glutamine-dependent carbamoyl-phosphate synthase inhibitor glutamine-dependent carbamoyl-phosphate synthase inhibitors glutamine-dependent carbamyl phosphate synthetase inhibitor glutamine-dependent carbamyl phosphate synthetase inhibitors hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitor hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitors EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor EC 6.3.4.* (other carbon--nitrogen ligases) inhibitor EC 6.3.4.* (other carbon--nitrogen ligases) inhibitors EC 6.3.4.* inhibitor EC 6.3.4.* inhibitors EC 6.3.4.* (other carbon--nitrogen ligases) inhibitor EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor CTP synthase (glutamine hydrolyzing) (EC6.3.4.2) inhibitor CTP synthase (glutamine hydrolyzing) (EC6.3.4.2) inhibitors CTP synthase (glutamine hydrolyzing) inhibitor CTP synthase (glutamine hydrolyzing) inhibitors CTP synthetase inhibitor CTP synthetase inhibitors CTPS inhibitor CTPS inhibitors EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitors EC 6.3.4.2 inhibitor EC 6.3.4.2 inhibitors UTP--ammonia ligase inhibitor UTP-ammonia ligase inhibitors UTP:L-glutamine amido-ligase (ADP-forming) inhibitor UTP:L-glutamine amido-ligase (ADP-forming) inhibitors cytidine triphosphate synthetase inhibitor cytidine triphosphate synthetase inhibitors pyrG inhibitor pyrG inhibitors uridine triphosphate aminase inhibitor uridine triphosphate aminase inhibitors EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitor 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitors 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming) inhibitor 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming) inhibitors EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitors EC 6.3.5.3 inhibitor EC 6.3.5.3 inhibitors FGAM synthase inhibitor FGAM synthase inhibitors FGAM synthetase inhibitor FGAM synthetase inhibitors FGAR amidotransferase inhibitor FGAR amidotransferase inhibitors FGARAT inhibitor FGARAT inhibitors N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitor N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitors formylglycinamide ribonucloetide amidotransferase inhibitor formylglycinamide ribonucloetide amidotransferase inhibitors formylglycinamide ribotide amidotransferase inhibitor formylglycinamide ribotide amidotransferase inhibitors phosphoribosylformylglycinamidine synthase inhibitor phosphoribosylformylglycinamidine synthase inhibitors phosphoribosylformylglycinamidine synthetase inhibitor phosphoribosylformylglycinamidine synthetase inhibitors phosphoribosylformylglycineamidine synthetase inhibitor phosphoribosylformylglycineamidine synthetase inhibitors EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitors EC 6.3.5.2 inhibitor EC 6.3.5.2 inhibitors GMP synthase (glutamine-hydrolysing) inhibitor GMP synthase (glutamine-hydrolysing) inhibitors GMP synthetase (glutamine-hydrolysing) inhibitor GMP synthetase (glutamine-hydrolysing) inhibitors guanosine 5'-monophosphate synthetase inhibitor guanosine 5'-monophosphate synthetase inhibitors guanosine monophosphate synthetase (glutamine-hydrolyzing) inhibitor guanosine monophosphate synthetase (glutamine-hydrolyzing) inhibitors guanylate synthetase (glutamine-hydrolyzing) inhibitor guanylate synthetase (glutamine-hydrolyzing) inhibitors xanthosine 5'-phosphate amidotransferase inhibitor xanthosine 5'-phosphate amidotransferase inhibitors xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) inhibitor xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) inhibitors EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor glutamine antagonist glutamine antagonists glutamine antagonist EC 4.1.1.39 (ribulose-bisphosphate carboxylase) inhibitor 3-phospho-D-glycerate carboxy-lyase (dimerizing) inhibitor 3-phospho-D-glycerate carboxy-lyase (dimerizing) inhibitors 3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming) inhibitor 3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming) inhibitors D-ribulose 1,5-bisphosphate carboxylase inhibitor D-ribulose 1,5-bisphosphate carboxylase inhibitors D-ribulose 1,5-diphosphate carboxylase inhibitor D-ribulose 1,5-diphosphate carboxylase inhibitors EC 4.1.1.39 (ribulose-bisphosphate carboxylase) inhibitors EC 4.1.1.39 inhibitor EC 4.1.1.39 inhibitors RuBP carboxylase inhibitor RuBP carboxylase inhibitors RuBisCO inhibitor RuBisCO inhibitors carboxydismutase inhibitor carboxydismutase inhibitors diphosphoribulose carboxylase inhibitor diphosphoribulose carboxylase inhibitors ribulose 1,5-bisphosphate carboxylase inhibitor ribulose 1,5-bisphosphate carboxylase inhibitors ribulose 1,5-bisphosphate carboxylase/oxygenase inhibitor ribulose 1,5-bisphosphate carboxylase/oxygenase inhibitors ribulose 1,5-diphosphate carboxylase inhibitor ribulose 1,5-diphosphate carboxylase inhibitors ribulose 1,5-diphosphate carboxylase/oxygenase inhibitor ribulose 1,5-diphosphate carboxylase/oxygenase inhibitors ribulose bisphosphate carboxylase/oxygenase inhibitor ribulose bisphosphate carboxylase/oxygenase inhibitors ribulose diphosphate carboxylase inhibitor ribulose diphosphate carboxylase inhibitors ribulose diphosphate carboxylase/oxygenase inhibitor ribulose diphosphate carboxylase/oxygenase inhibitors ribulose-bisphosphate carboxylase inhibitor ribulose-bisphosphate carboxylase inhibitors rubisco inhibitor rubisco inhibitors EC 4.1.1.39 (ribulose-bisphosphate carboxylase) inhibitor EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor 5'-phosphoribosylpyrophosphate amidotransferase inhibitor 5'-phosphoribosylpyrophosphate amidotransferase inhibitors 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitor 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitors 5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitor 5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitors 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitor 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitors 5-phosphororibosyl-1-pyrophosphate amidotransferase inhibitor 5-phosphororibosyl-1-pyrophosphate amidotransferase inhibitors EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitors EC 2.4.2.14 inhibitor EC 2.4.2.14 inhibitors alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitor alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitors amidophosphoribosyltransferase (EC 2.4.2.14) inhibitor amidophosphoribosyltransferase (EC 2.4.2.14) inhibitors amidophosphoribosyltransferase inhibitor amidophosphoribosyltransferase inhibitors glutamine 5-phosphoribosylpyrophosphate amidotransferase inhibitor glutamine 5-phosphoribosylpyrophosphate amidotransferase inhibitors glutamine phosphoribosyldiphosphate amidotransferase inhibitor glutamine phosphoribosyldiphosphate amidotransferase inhibitors glutamine phosphoribosylpyrophosphate amidotransferase inhibitor glutamine phosphoribosylpyrophosphate amidotransferase inhibitors glutamine ribosylpyrophosphate 5-phosphate amidotransferase inhibitor glutamine ribosylpyrophosphate 5-phosphate amidotransferase inhibitors phosphoribose pyrophosphate amidotransferase inhibitor phosphoribose pyrophosphate amidotransferase inhibitors phosphoribosyl pyrophosphate amidotransferase inhibitor phosphoribosyl pyrophosphate amidotransferase inhibitors phosphoribosyldiphosphate 5-amidotransferase inhibitor phosphoribosyldiphosphate 5-amidotransferase inhibitors phosphoribosylpyrophosphate glutamyl amidotransferase inhibitor phosphoribosylpyrophosphate glutamyl amidotransferase inhibitors EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor DPN synthetase inhibitor DPN synthetase inhibitors EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitors EC 6.3.5.1 inhibitor EC 6.3.5.1 inhibitors NAD synthetase (glutamine-hydrolysing) inhibitor NAD synthetase (glutamine-hydrolysing) inhibitors NAD(+) synthase (glutamine-hydrolysing) (EC 6.3.5.1) inhibitor NAD(+) synthase (glutamine-hydrolysing) (EC 6.3.5.1) inhibitors NAD(+) synthase (glutamine-hydrolysing) inhibitor NAD(+) synthase (glutamine-hydrolysing) inhibitors NAD(+) synthetase (glutamine-hydrolyzing) inhibitor NAD(+) synthetase (glutamine-hydrolyzing) inhibitors deamido-NAD(+):L-glutamine amido-ligase (AMP-forming) inhibitor deamido-NAD(+):L-glutamine amido-ligase (AMP-forming) inhibitors desamidonicotinamide adenine dinucleotide amidotransferase inhibitor desamidonicotinamide adenine dinucleotide amidotransferase inhibitors nicotinamide adenine dinucleotide synthetase (glutamine) inhibitor nicotinamide adenine dinucleotide synthetase (glutamine) inhibitors EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor AS inhibitor AS inhibitors AS-B inhibitor AS-B inhibitors EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitors EC 6.3.5.4 inhibitor EC 6.3.5.4 inhibitors L-aspartate:L-glutamine amido-ligase (AMP-forming) inhibitor L-aspartate:L-glutamine amido-ligase (AMP-forming) inhibitors asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) inhibitor asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) inhibitors asparagine synthase (glutamine-hydrolysing) inhibitor asparagine synthase (glutamine-hydrolysing) inhibitors asparagine synthetase (glutamine-hydrolysing) inhibitor asparagine synthetase (glutamine-hydrolysing) inhibitors asparagine synthetase B inhibitor asparagine synthetase B inhibitors glutamine-dependent asparagine synthetase inhibitor glutamine-dependent asparagine synthetase inhibitors EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor quorum sensing inhibitor QS inhibitor QS inhibitors QSI QSIs quorum sensing inhibitors quorum sensing inhibitor thromboxane A2 agonist TXA2/PGH2 agonist TXA2/PGH2 agonists TXA2/PGH2 receptor agonist TXA2/PGH2 receptor agonists thromboxane A2 agonists thromboxane A2 receptor agonist thromboxane A2 receptor agonists thromboxane A2 agonist PERK inhibitor PERK inhibitors PKR-like endoplasmic reticulum kinase inhibitor PKR-like endoplasmic reticulum kinase inhibitors protein kinase R-like endoplasmic reticulum kinase inhibitor protein kinase R-like endoplasmic reticulum kinase inhibitors PERK inhibitor LIM kinase inhibitor LIM kinase inhibitors LIM kinase inhibitor cis-Golgi ArfGEF GBF inhibitor cis-Golgi ArfGEF GBF inhibitor IP3 receptor agonist D-myo-inositol 1,4,5-trisphosphate receptor agonist D-myo-inositol 1,4,5-trisphosphate receptor agonists IP3 agonist IP3 agonists IP3 receptor agonists InsP3R agonist InsP3R agonists inositol trisphosphate receptor agonist inositol trisphosphate receptor agonists IP3 receptor agonist EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitors EC 2.4.1.255 inhibitor EC 2.4.1.255 inhibitors O-GlcNAc transferase inhibitor O-GlcNAc transferase inhibitors O-linked N-acetylglucosaminyltransferase inhibitor O-linked N-acetylglucosaminyltransferase inhibitors OGTase inhibitor OGTase inhibitors UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase inhibitor UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase inhibitors protein O-GlcNAc transferase (EC 2.4.1.255) inhibitor protein O-GlcNAc transferase (EC 2.4.1.255) inhibitors protein O-GlcNAc transferase inhibitor protein O-GlcNAc transferase inhibitors protein O-linked beta-N-acetylglucosamine transferase inhibitor protein O-linked beta-N-acetylglucosamine transferase inhibitors uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase inhibitor uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase inhibitors EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor melanin-concentrating hormone receptor antagonist MCHR agonist MCHR agonists melanin-concentrating hormone receptor antagonists melanin-concentrating hormone receptor antagonist nicotinic acid adenine dinucleotide phosphate receptor antagonist NAADP antagonist NAADP antagonists NAADP receptor antagonist NAADP receptor antagonists nicotinic acid adenine dinucleotide phosphate receptor antagonists nicotinic acid adenine dinucleotide phosphate receptor antagonist peptide probe peptide probe EC 1.14.17.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen and with reduced ascorbate as one donor, and incorporation of one atom of oxygen) inhibitor EC 1.14.17.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen and with reduced ascorbate as one donor, and incorporation of one atom of oxygen) inhibitor EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor (3,4-dihydroxyphenethylamine)beta-mono-oxygenase inhibitor (3,4-dihydroxyphenethylamine)beta-mono-oxygenase inhibitors 3,4-dihydroxyphenethylamine beta-oxidase inhibitor 3,4-dihydroxyphenethylamine beta-oxidase inhibitors 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating) inhibitor 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating) inhibitors 4-(2-aminoethyl)pyrocatechol beta-oxidase inhibitor 4-(2-aminoethyl)pyrocatechol beta-oxidase inhibitors DbetaH inhibitor DbetaH inhibitors EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitors EC 1.14.17.1 inhibitor EC 1.14.17.1 inhibitors MDBH (membrane-associated dopamine beta-monooxygenase) inhibitor MDBH (membrane-associated dopamine beta-monooxygenase) inhibitors SDBH (soluble dopamine beta-monooxygenase) inhibitor SDBH (soluble dopamine beta-monooxygenase) inhibitors dopa beta-hydroxylase inhibitor dopa beta-hydroxylase inhibitors dopamine beta-hydroxylase inhibitor dopamine beta-hydroxylase inhibitors dopamine beta-monooxygenase (EC 1.14.17.1) inhibitor dopamine beta-monooxygenase (EC 1.14.17.1) inhibitors dopamine beta-monooxygenase inhibitor dopamine beta-monooxygenase inhibitors dopamine beta-oxidase inhibitor dopamine beta-oxidase inhibitors dopamine hydroxylase inhibitor dopamine hydroxylase inhibitors dopamine-B-hydroxylase inhibitor dopamine-B-hydroxylase inhibitors oxygenase, dopamine beta-mono-phenylamine beta-hydroxylase inhibitor oxygenase, dopamine beta-mono-phenylamine beta-hydroxylase inhibitors EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor TRP channel blocker TRP channel blockers transient receptor potential channel blocker transient receptor potential channel blockers TRP channel blocker sensitiser sensitisers sensitizer sensitizers sensitiser vitamin D receptor agonist VDR agonist VDR agonists calcitriol receptor agonist calcitriol receptor agonists vitamin D nuclear receptor agonist vitamin D nuclear receptor agonists vitamin D receptor agonists vitamin D receptor agonist EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitors EC 1.3.1.9 inhibitor EC 1.3.1.9 inhibitors ENR inhibitor ENR inhibitors NADH-enoyl acyl carrier protein reductase inhibitor NADH-enoyl acyl carrier protein reductase inhibitors NADH-specific enoyl-ACP reductase inhibitor NADH-specific enoyl-ACP reductase inhibitors acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitor acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitors enoyl-ACP reductase inhibitor enoyl-ACP reductase inhibitors enoyl-[acyl carrier protein] reductase inhibitor enoyl-[acyl carrier protein] reductase inhibitors EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor EC 4.1.1.17 (ornithine decarboxylase) inhibitor EC 4.1.1.17 (ornithine decarboxylase) inhibitors EC 4.1.1.17 inhibitor EC 4.1.1.17 inhibitors L-ornithine carboxy-lyase (putrescine-forming) inhibitor L-ornithine carboxy-lyase (putrescine-forming) inhibitors L-ornithine carboxy-lyase inhibitor L-ornithine carboxy-lyase inhibitors ODC inhibitor ODC inhibitors SpeC inhibitor SpeC inhibitors EC 4.1.1.17 (ornithine decarboxylase) inhibitor Jacobaea metabolite Jacobaea metabolites Jacobaea metabolite lysophosphatidic acid receptor 3 agonist LPA3 agonist LPA3 agonists LPAR3 agonist LPAR3 agonists lysophosphatidic acid receptor 3 agonists lysophosphatidic acid receptor 3 agonist survivin suppressant survivin suppressants survivin suppressor survivin suppressors survivin suppressant TRPV4 agonist OSM9-like transient receptor potential channel, member 4 agonist OSM9-like transient receptor potential channel, member 4 agonists OTRPC4 agonist OTRPC4 agonists TRPV4 agonists VR-OAC agonist VR-OAC agonists transient receptor potential +agonist transient receptor potential cation channel subfamily V member 4 agonist transient receptor potential cation channel subfamily V member 4 agonists transient receptor potential vanilloid 4 agonists transient receptor vanilloid-4 agonist transient receptor vanilloid-4 agonists vanilloid-receptor related osmotically activated channel agonist vanilloid-receptor related osmotically activated channel agonists TRPV4 agonist Camellia sinensis metabolite C. sinensis metabolite C. sinensis metabolites Camellia sinensis metabolites Camellia sinensis metabolite Brassica napus metabolite Brassica napus metabolites rapeseed metabolite rapeseed metabolites Brassica napus metabolite calcium-dependent antibiotics Ca(2+)-dependent antibiotic Ca(2+)-dependent antibiotics Ca-dependent antibiotic Ca-dependent antibiotics calcium-dependent antibiotic calcium-dependent antibiotics EC 1.1.1.37 (malate dehydrogenase) inhibitor (S)-malate:NAD(+) oxidoreductase inhibitor (S)-malate:NAD(+) oxidoreductase inhibitors EC 1.1.1.37 (malate dehydrogenase) inhibitors EC 1.1.1.37 inhibitor EC 1.1.1.37 inhibitors L-malate dehydrogenase inhibitor L-malate dehydrogenase inhibitors L-malate-NAD(+) oxidoreductase inhibitor L-malate-NAD(+) oxidoreductase inhibitors MDH inhibitor MDH inhibitors NAD-L-malate dehydrogenase inhibitor NAD-L-malate dehydrogenase inhibitors NAD-dependent malate dehydrogenase inhibitor NAD-dependent malate dehydrogenase inhibitors NAD-dependent malic dehydrogenase inhibitor NAD-dependent malic dehydrogenase inhibitors NAD-linked malate dehydrogenase inhibitor NAD-linked malate dehydrogenase inhibitors NAD-malate dehydrogenase inhibitor NAD-malate dehydrogenase inhibitors NAD-malic dehydrogenase inhibitor NAD-malic dehydrogenase inhibitors NAD-specific malate dehydrogenase inhibitor NAD-specific malate dehydrogenase inhibitors malate (NAD) dehydrogenase inhibitor malate (NAD) dehydrogenase inhibitors malate dehydrogenase (EC 1.1.1.37) inhibitor malate dehydrogenase (EC 1.1.1.37) inhibitors malate dehydrogenase inhibitor malate dehydrogenase inhibitors malic acid dehydrogenase inhibitor malic acid dehydrogenase inhibitors malic dehydrogenase inhibitor malic dehydrogenase inhibitors EC 1.1.1.37 (malate dehydrogenase) inhibitor specialised pro-resolving mediator SPM SPMs specialised pro-resolving mediators specialised proresolving mediator specialised proresolving mediators specialized pro-resolving mediator specialized pro-resolving mediators specialized proresolving mediator specialized proresolving mediators specialised pro-resolving mediator neurokinin-3 receptor antagonist NK-3 receptor antagonist NK-3 receptor antagonists NK3 receptor antagonist NK3 receptor antagonists NK3R antagonist NK3R antagonists neurokinin-3 receptor antagonists neurokinin-3 receptor antagonist tropomyosin-related kinase B receptor agonist TrkB receptor agonist TrkB receptor agonists tropomyosin-related kinase B receptor agonists tropomyosin-related kinase B receptor agonist TRPV1 agonist TRPV1 agonists capsaicin receptor agonist capsaicin receptor agonists transient receptor potential cation channel subfamily V member 1 agonist transient receptor potential cation channel subfamily V member 1 agonists transient receptor potential vanilloid 1 agonist transient receptor potential vanilloid 1 agonists vanilloid receptor 1 agonist vanilloid receptor 1 agonists TRPV1 agonist Arabidopsis thaliana metabolite Arabidopsis thaliana metabolites Arabidopsis thaliana metabolite secreted frizzled-related protein 1 inhibitor SFRP1 inhibitor SFRP1 inhibitors sFRP-1 inhibitor sFRP-1 inhibitors secreted frizzled-related protein 1 inhibitors secreted frizzled-related protein-1 inhibitor secreted frizzled-related protein-1 inhibitors secreted frizzled-related protein 1 inhibitor Hedgehog signaling pathway inhibitor Hedgehog pathway inhibitor Hedgehog pathway inhibitors Hedgehog signaling pathway inhibitors Hedgehog signaling pathway inhibitor glioma-associated oncogene inhibitor GLI inhibitor GLI inhibitors glioma-associated oncogene inhibitors glioma-associated oncogene inhibitor neuropeptide FF receptor antagonist NPFF receptor antagonist NPFF receptor antagonists NPFFR antagonist NPFFR antagonists neuropeptide FF receptor antagonists neuropeptide FF receptor antagonist neuropeptide FF receptor agonist NPFF receptor agonist NPFF receptor agonists neuropeptide FF receptor agonists neuropeptide FF receptor agonist kisspeptin receptor agonist kisspeptin receptor agonists kisspeptin receptor agonist quinone outside inhibitor QOI QOIs Qo inhibitor Qo inhibitors quinone outside inhibitors quinone outside inhibitor pronematicide pronematicides pronematocide pronematocides pronematicide 5-hydroxytryptamine 2B receptor agonist 5-HT2B agonist 5-HT2B agonists 5-HT2B receptor agonist 5-HT2B receptor agonists 5-hydroxytryptamine 2B receptor agonists 5-hydroxytryptamine receptor 2B agonist 5-hydroxytryptamine receptor 2B agonists serotonin receptor 2B agonist serotonin receptor 2B agonists 5-hydroxytryptamine 2B receptor agonist 5-hydroxytryptamine 2C receptor agonist 5-HT2C receptor agonist 5-HT2C receptor agonists 5-HT2c agonist 5-HT2c agonists 5-hydroxytryptamine 2C receptor agonists 5-hydroxytryptamine receptor 2C agonist 5-hydroxytryptamine receptor 2C agonists serotonin receptor 2C agonist serotonin receptor 2C agonists 5-hydroxytryptamine 2C receptor agonist EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitor (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating) inhibitor (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating) inhibitors CYP4F2 inhibitor CYP4F2 inhibitors CYP4F3 inhibitor CYP4F3 inhibitors EC 1.14.13.30 inhibitor EC 1.14.13.30 inhibitors EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitors EC 1.14.14.94 inhibitor EC 1.14.14.94 inhibitors LTB4 20-hydroxylase inhibitor LTB4 20-hydroxylase inhibitors LTB4 omega-hydroxylase inhibitor LTB4 omega-hydroxylase inhibitors leucotriene-B4 omega-hydroxylase inhibitor leucotriene-B4 omega-hydroxylase inhibitors leukotriene-B4 20-hydroxylase inhibitor leukotriene-B4 20-hydroxylase inhibitors leukotriene-B4 20-monooxygenase (EC 1.14.14.94) inhibitors leukotriene-B4 20-monooxygenase inhibitor leukotriene-B4 20-monooxygenase inhibitors EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitor EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor 1-hydroxylase inhibitor 1-hydroxylase inhibitors EC 1.14.15.3 (alkane 1-monooxygenase) inhibitors EC 1.14.15.3 inhibitor EC 1.14.15.3 inhibitors alkane 1-hydroxylase inhibitor alkane 1-hydroxylase inhibitors alkane 1-monooxygenase (EC 1.14.15.3) inhibitor alkane 1-monooxygenase (EC 1.14.15.3) inhibitors alkane 1-monooxygenase inhibitor alkane 1-monooxygenase inhibitors alkane hydroxylase inhibitor alkane hydroxylase inhibitors alkane monooxygenase inhibitor alkane monooxygenase inhibitors alkane,reduced-rubredoxin:oxygen 1-oxidoreductase inhibitor alkane,reduced-rubredoxin:oxygen 1-oxidoreductase inhibitors fatty acid omega-hydroxylase inhibitor fatty acid omega-hydroxylase inhibitors omega-hydroxylase inhibitor omega-hydroxylase inhibitors EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor EC 4.1.1.15 (glutamate decarboxylase) inhibitor EC 4.1.1.15 (glutamate decarboxylase) inhibitors EC 4.1.1.15 inhibitor EC 4.1.1.15 inhibitors L-aspartate-alpha-decarboxylase inhibitor L-aspartate-alpha-decarboxylase inhibitors L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) inhibitor L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) inhibitors L-glutamate 1-carboxy-lyase inhibitor L-glutamate 1-carboxy-lyase inhibitors L-glutamate alpha-decarboxylase inhibitor L-glutamate alpha-decarboxylase inhibitors L-glutamic acid decarboxylase inhibitor L-glutamic acid decarboxylase inhibitors L-glutamic decarboxylase inhibitor L-glutamic decarboxylase inhibitors aspartate 1-decarboxylase inhibitor aspartate 1-decarboxylase inhibitors aspartic alpha-decarboxylase inhibitor aspartic alpha-decarboxylase inhibitors cysteic acid decarboxylase inhibitor cysteic acid decarboxylase inhibitors gamma-glutamate decarboxylase inhibitor gamma-glutamate decarboxylase inhibitors glutamate decarboxylase (EC 4.1.1.15) inhibitor glutamate decarboxylase (EC 4.1.1.15) inhibitors glutamate decarboxylase inhibitor glutamate decarboxylase inhibitors EC 4.1.1.15 (glutamate decarboxylase) inhibitor tau aggregation inhibitor TAI tau aggregation inhibitor tau aggregation inhibitors tau protein aggregation inhibitor tau protein aggregation inhibitors tau-aggregation inhibitor tau-aggregation inhibitors tau aggregation inhibitor EC 2.5.1.117 (homogentisate solanesyltransferase) inhibitor EC 2.5.1.117 (homogentisate solanesyltransferase) inhibitor TRPV channel modulator TRPV channel modulators transient receptor potential (vanilloid) channel modulator transient receptor potential (vanilloid) channel modulators TRPV channel modulator TRP channel modulator TRP channel modulators TRP channel modulator EC 3.3.2.10 (soluble epoxide hydrolase) inhibitor sEHi soluble epoxide hydrolase inhibitor soluble epoxide hydrolase inhibitors EC 3.3.2.10 (soluble epoxide hydrolase) inhibitor GABAB receptor agonist GABAB receptor agonist EC 2.1.3.* (carboxy- and carbamoyltransferases) inhibitor EC 2.1.3.* (carboxy- and carbamoyltransferases) inhibitors EC 2.1.3.* (carboxytransferase and carbamoyltransferase) inhibitor EC 2.1.3.* (carboxytransferase and carbamoyltransferase) inhibitors EC 2.1.3.* inhibitor EC 2.1.3.* inhibitors carboxy- and carbamoyltransferase (EC 2.1.3.*) inhibitor carboxy- and carbamoyltransferase (EC 2.1.3.*) inhibitors EC 2.1.3.* (carboxy- and carbamoyltransferases) inhibitor EC 2.1.3.3 (ornithine carbamoyltransferase) inhibitor EC 2.1.3.3 (ornithine carbamoyltransferase) inhibitors EC 2.1.3.3 inhibitor EC 2.1.3.3 inhibitors L-ornithine carbamoyltransferase inhibitor L-ornithine carbamoyltransferase inhibitors L-ornithine carbamyltransferase inhibitor L-ornithine carbamyltransferase inhibitors L-ornithine transcarbamylase inhibitor L-ornithine transcarbamylase inhibitors OTC inhibitor OTC inhibitors carbamoyl-phosphate:L-ornithine carbamoyltransferase inhibitor carbamoyl-phosphate:L-ornithine carbamoyltransferase inhibitors carbamylphosphate-ornithine transcarbamylase inhibitor carbamylphosphate-ornithine transcarbamylase inhibitors citrulline phosphorylase inhibitor citrulline phosphorylase inhibitors ornithine carbamoyltransferase (EC 2.1.3.3) inhibitor ornithine carbamoyltransferase (EC 2.1.3.3) inhibitors ornithine carbamoyltransferase inhibitor ornithine carbamoyltransferase inhibitors ornithine carbamyltransferase inhibitor ornithine carbamyltransferase inhibitors ornithine transcarbamylase inhibitor ornithine transcarbamylase inhibitors EC 2.1.3.3 (ornithine carbamoyltransferase) inhibitor impurity contaminant contaminants impurities impurity impurity peptide allergen allergenic peptide peptide allergen carbohydrate allergen allergenic carbohydrate allergenic carbohydrate derivative carbohydrate allergen ceramide allergen allergenic ceramide ceramide allergen EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor CYP51 inhibitor CYP51 inhibitors EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitors EC 1.14.14.154 inhibitor EC 1.14.14.154 inhibitors ERG11 inhibitor ERG11 inhibitors cytochrome P450 51 inhibitor cytochrome P450 51 inhibitors lanosterol 14-demethylase inhibitor lanosterol 14-demethylase inhibitors lanosterol 14alpha-demethylase inhibitor lanosterol 14alpha-demethylase inhibitors obtusufoliol 14-demethylase inhibitor obtusufoliol 14-demethylase inhibitors oxidoreductase (14-methyl cleaving) inhibitors sterol 14-demethylase inhibitor sterol 14-demethylase inhibitors sterol 14alpha-demethylase (EC 1.14.14.154) inhibitor sterol 14alpha-demethylase (EC 1.14.14.154) inhibitors sterol 14alpha-demethylase inhibitor sterol 14alpha-demethylase inhibitors sterol,[reduced NADPH--hemoprotein reductase]:oxygen inhibitor sterol,[reduced NADPH--hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) inhibitor EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor EC 2.7.1.40 (pyruvate kinase) inhibitor EC 2.7.1.40 inhibitor EC 2.7.1.40 inhibitors phosphoenol transphosphorylase inhibitor phosphoenol transphosphorylase inhibitors phosphoenolpyruvate kinase inhibitor phosphoenolpyruvate kinase inhibitors pyruvate kinase inhibitor pyruvate kinase inhibitors EC 2.7.1.40 (pyruvate kinase) inhibitor EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) inhibitor C27-side chain cleavage enzyme inhibitor C27-side chain cleavage enzyme inhibitors EC 1.14.15.6 inhibitor EC 1.14.15.6 inhibitors cholesterol 20-22-desmolase inhibitor cholesterol 20-22-desmolase inhibitors cholesterol C20-22 desmolase inhibitor cholesterol C20-22 desmolase inhibitors cholesterol desmolase inhibitor cholesterol desmolase inhibitors cholesterol monooxygenase (side-chain-cleaving) inhibitor cholesterol monooxygenase (side-chain-cleaving) inhibitors cholesterol side-chain cleavage enzyme inhibitor cholesterol side-chain cleavage enzyme inhibitors cholesterol side-chain-cleaving enzyme inhibitor cholesterol side-chain-cleaving enzyme inhibitors cytochrome P-450scc inhibitor cytochrome P-450scc inhibitors steroid 20-22 desmolase inhibitor steroid 20-22 desmolase inhibitors steroid 20-22-lyase inhibitor steroid 20-22-lyase inhibitors EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) inhibitor EC 1.4.3.2 (L-amino-acid oxidase) inhibitor EC 1.4.3.2 (L-amino-acid oxidase) inhibitors EC 1.4.3.2 inhibitor EC 1.4.3.2 inhibitors L-amino-acid oxidase inhibitor L-amino-acid oxidase inhibitor (EC 1.4.3.2) inhibitor L-amino-acid oxidase inhibitor (EC 1.4.3.2) inhibitors L-amino-acid oxidase inhibitors L-amino-acid:oxygen oxidoreductase (deaminating) inhibitor L-amino-acid:oxygen oxidoreductase (deaminating) inhibitors ophio-amino-acid oxidase inhibitor ophio-amino-acid oxidase inhibitors EC 1.4.3.2 (L-amino-acid oxidase) inhibitor EC 2.6.1.2 (alanine transaminase) inhibitor EC 2.6.1.2 (alanine transaminase) inhibitor EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor (6-phosphofructo-2-kinase) inhibitors 6-phosphofructo-2-kinase (phosphorylating) inhibitor 6-phosphofructo-2-kinase (phosphorylating) inhibitors 6-phosphofructo-2-kinase inhibitor 6-phosphofructo-2-kinase inhibitors 6-phosphofructose 2-kinase inhibitor 6-phosphofructose 2-kinase inhibitors EC 2.7.1.105 inhibitor EC 2.7.1.105 inhibitors fructose 6-phosphate 2-kinase inhibitor fructose 6-phosphate 2-kinase inhibitors phosphofructokinase 2 inhibitor phosphofructokinase 2 inhibitors EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor EC 3.1.1.64 (retinoid isomerohydrolase) inhibitors EC 3.1.1.64 inhibitor EC 3.1.1.64 inhibitors RPE65 inhibitor RPE65 inhibitors all-trans-retinol isomerase:hydrolase inhibitor all-trans-retinol isomerase:hydrolase inhibitors all-trans-retinyl-palmitate hydrolase inhibitor all-trans-retinyl-palmitate hydrolase inhibitors all-trans-retinylester 11-cis isomerohydrolase inhibitor all-trans-retinylester 11-cis isomerohydrolase inhibitors retinoid isomerohydrolase inhibitor retinoid isomerohydrolase inhibitors retinol isomerase inhibitor retinol isomerase inhibitors EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor tumour antigen tumour antigens tumour antigen C5a receptor antagonist C5AR1 antagonist C5AR1 antagonists C5a receptor antagonists CD88 antagonist CD88 antagonists cluster of differentiation 88 antagonist cluster of differentiation 88 antagonists complement component 5a receptor 1 antagonist complement component 5a receptor 1 antagonists C5a receptor antagonist EC 3.6.5.2 (small monomeric GTPase) inhibitor EC 3.6.5.2 (small monomeric GTPase) inhibitor sphingosine-1-phosphate receptor antagonist EDG receptor antagonist S1P receptor antagonist S1P receptor antagonists SIP antagonist SIP antagonists sphingosine 1-phosphate receptor antagonist sphingosine 1-phosphate receptor antagonists sphingosine-1-phosphate receptor antagonists sphingosine-1-phosphate receptor antagonist sphingosine-1-phosphate receptor 3 antagonist S1PR3 antagonist S1PR3 antagonists sphingosine-1-phosphate receptor 3 antagonists sphingosine-1-phosphate receptor 3 antagonist sphingosine-1-phosphate receptor 1 antagonist S1PR1 antagonist S1PR1 antagonists sphingosine-1-phosphate receptor 1 antagonists sphingosine-1-phosphate receptor 1 antagonist antispermatogenic agent antispermatogenic antispermatogenic agents antispermatogenics antispermatogenic agent hyaluronan synthesis inhibitor HA synthesis inhibitor HA synthesis inhibitors hyaluronan synthesis inhibitors hyaluronic acid synthesis inhibitor hyaluronic acid synthesis inhibitors hyaluronan synthesis inhibitor EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor EC 1.1.1.42 inhibitor EC 1.1.1.42 inhibitors IDH inhibitor IDH inhibitors IDP inhibitor IDP inhibitors IDP1 inhibitor IDP1 inhibitors IDP2 inhibitor IDP2 inhibitors IDP3 inhibitor IDP3 inhibitors NADP isocitric dehydrogenase inhibitor NADP isocitric dehydrogenase inhibitors NADP(+)-ICDH inhibitor NADP(+)-ICDH inhibitors NADP(+)-IDH inhibitor NADP(+)-IDH inhibitors NADP(+)-linked isocitrate dehydrogenase inhibitor NADP(+)-linked isocitrate dehydrogenase inhibitors NADP-dependent isocitrate dehydrogenase inhibitor NADP-dependent isocitrate dehydrogenase inhibitors NADP-dependent isocitric dehydrogenase inhibitor NADP-dependent isocitric dehydrogenase inhibitors NADP-linked isocitrate dehydrogenase inhibitor NADP-linked isocitrate dehydrogenase inhibitors NADP-specific isocitrate dehydrogenase inhibitor NADP-specific isocitrate dehydrogenase inhibitors dual-cofactor-specific isocitrate dehydrogenase inhibitor dual-cofactor-specific isocitrate dehydrogenase inhibitors isocitrate (NADP) dehydrogenase inhibitor isocitrate (NADP) dehydrogenase inhibitors isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase inhibitor isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase inhibitors isocitrate dehydrogenase (NADP(+)) inhibitor isocitrate dehydrogenase (NADP(+)) inhibitors isocitrate dehydrogenase (NADP-dependent) inhibitor isocitrate dehydrogenase (NADP-dependent) inhibitors isocitrate dehydrogenase inhibitor isocitrate dehydrogenase inhibitors oxalosuccinate decarboxylase inhibitor oxalosuccinate decarboxylase inhibitors oxalsuccinic decarboxylase inhibitor oxalsuccinic decarboxylase inhibitors triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase inhibitor triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase inhibitors EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor EC 2.7.11.21 (polo kinase) inhibitor Cdc5 inhibitor Cdc5 inhibitors Cdc5p inhibitor Cdc5p inhibitors EC 2.7.11.21 (polo kinase) inhibitors EC 2.7.11.21 inhibitor EC 2.7.11.21 inhibitors PLK inhibitor PLK inhibitors Plk inhibitor Plk inhibitors Plk1 inhibitor Plk1 inhibitors Plo1 inhibitor Plo1 inhibitors STK21 inhibitor STK21 inhibitors polo kinase inhibitor polo kinase inhibitors polo serine-threonine kinase inhibitor polo serine-threonine kinase inhibitors polo-like kinase 1 inhibitor polo-like kinase 1 inhibitors polo-like kinase inhibitor polo-like kinase inhibitors serine/threonine-specific Drosophila kinase polo inhibitor serine/threonine-specific Drosophila kinase polo inhibitors EC 2.7.11.21 (polo kinase) inhibitor uncoupling protein inhibitor UCP inhibitor UCP inhibitors mitochondrial uncoupling protein inhibitor mitochondrial uncoupling protein inhibitors uncoupling protein inhibitors uncoupling protein inhibitor C-X-C chemokine receptor type 4 antagonist C-X-C chemokine receptor type 4 antagonists C-X-C motif chemokine receptor 4 antagonist C-X-C motif chemokine receptor 4 antagonists CD184 antagonist CD184 antagonists CXCR-4 antagonist CXCR-4 antagonists CXCR4 antagonist CXCR4 antagonists chemokine (C-X-C motif) receptor 4 antagonist chemokine (C-X-C motif) receptor 4 antagonists fusin antagonist fusin antagonists C-X-C chemokine receptor type 4 antagonist GABAA receptor antagonist GABAA receptor antagonist forkhead box protein O1 inhibitor FOXO1 inhibitor FOXO1 inhibitors Foxo1 inhibitor Foxo1 inhibitors forkhead box protein O1 inhibitors forkhead in rhabdomyosarcoma inhibitor forkhead in rhabdomyosarcoma inhibitors forkhead box protein O1 inhibitor EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor ASA dehydrogenase inhibitor ASA dehydrogenase inhibitors EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitors EC 1.2.1.11 inhibitor EC 1.2.1.11 inhibitors L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) inhibitor L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) inhibitors L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating) inhibitor L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating) inhibitors aspartate semialdehyde dehydrogenase inhibitor aspartate semialdehyde dehydrogenase inhibitors aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) inhibitor aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) inhibitors aspartate-semialdehyde dehydrogenase inhibitor aspartate-semialdehyde dehydrogenase inhibitors aspartic beta-semialdehyde dehydrogenase inhibitor aspartic beta-semialdehyde dehydrogenase inhibitors aspartic semialdehyde dehydrogenase inhibitor aspartic semialdehyde dehydrogenase inhibitors EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor antiatherosclerotic agent anti-atherosclerotic agent anti-atherosclerotic agents anti-atherosclerotic drug anti-atherosclerotic drugs antiatherosclerotic agent antiatherosclerotic agents antiatherosclerotic drug antiatherosclerotic drugs antiatherosclerotic agent 5-hydroxytryptamine 2A receptor agonist 5-HT2A agonist 5-HT2A agonists 5-HT2A receptor agonist 5-HT2A receptor agonists 5-hydroxytryptamine 2A receptor agonists 5-hydroxytryptamine receptor 2A agonist 5-hydroxytryptamine receptor 2A agonists serotonin receptor 2A agonist serotonin receptor 2A agonists 5-hydroxytryptamine 2A receptor agonist ryanoid insecticide ryanoid insecticide ryanodine receptor antagonist ryanodine receptor antagonist CB2 receptor agonist CB2 receptor agonist CB2 receptor agonists CB2R agonist CB2R agonists cannabinoid receptor 2 agonist cannabinoid receptor 2 agonists cannabinoid receptor type 2 agonist cannabinoid receptor type 2 agonists type 2 cannabinoid receptor agonist type 2 cannabinoid receptor agonists CB2 receptor agonist oneirogen oneirogens oneirogen EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor 3C-like protease inhibitor 3C-like protease inhibitors 3cLpro inhibitor 3cLpro inhibitors EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitors EC 3.4.22.69 inhibitor EC 3.4.22.69 inhibitors Mpro inhibitor Mpro inhibitors SARS 3C-like protease inhibitor SARS 3C-like protease inhibitors SARS coronavirus 3CL protease inhibitor SARS coronavirus 3CL protease inhibitors SARS coronavirus main peptidase inhibitor SARS coronavirus main peptidase inhibitors SARS coronavirus main protease inhibitor SARS coronavirus main protease inhibitors SARS coronavirus main proteinase inhibitor SARS coronavirus main proteinase inhibitors SARS-CoV 3CLpro enzyme inhibitor SARS-CoV 3CLpro enzyme inhibitors SARS-CoV Mpro inhibitor SARS-CoV Mpro inhibitors SARS-CoV main protease inhibitor SARS-CoV main protease inhibitors coronavirus 3C-like protease inhibitor coronavirus 3C-like protease inhibitors severe acute respiratory syndrome coronavirus main protease inhibitor severe acute respiratory syndrome coronavirus main protease inhibitors EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor ACE-2 inhibitor ACE-2 inhibitors ACE2 inhibitor ACE2 inhibitors EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitors EC 3.4.17.23 inhibitor EC 3.4.17.23 inhibitors angiotensin converting enzyme 2 inhibitor angiotensin converting enzyme 2 inhibitors angiotensin converting enzyme-2 inhibitor angiotensin converting enzyme-2 inhibitors angiotensin-converting enzyme 2 inhibitor angiotensin-converting enzyme 2 inhibitors hACE2 inhibitor hACE2 inhibitors EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor EC 3.4.17* (metallocarboxypeptidase) inhibitor EC 3.4.17* (metallocarboxypeptidase) inhibitor EC 3.4.17* (metallocarboxypeptidase) inhibitors EC 3.4.17.* inhibitor EC 3.4.17.* inhibitors metallocarboxypeptidase inhibitor metallocarboxypeptidase inhibitors EC 3.4.17* (metallocarboxypeptidase) inhibitor nitrification inhibitor nitrification inhibitors nitrification inhibitor spin trapping reagent spin trap spin trapping reagents spin traps spin trapping reagent emetic emetics emetic anticoronaviral agent anti-coronaviral agent anti-coronaviral agents anti-coronavirus agent anti-coronavirus agents anticoronaviral agent anticoronaviral agents anticoronaviral drug anticoronaviral drugs anticoronavirus agent anticoronavirus agents anticoronviral agent anticoronviral agents anticoronaviral agent EC 2.3.3.8 (ATP citrate synthase) inhibitor ATP citrate (pro-S)-lyase inhibitor ATP citrate (pro-S)-lyase inhibitors ATP citrate lyase inhibitor ATP citrate lyase inhibitors ATP citrate synthase inhibitor ATP citrate synthase inhibitors ATP-citric lyase inhibitor ATP-citric lyase inhibitors ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO(-)->acetyl-CoA] (ATP-dephosphorylating) inhibitor ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO(-)->acetyl-CoA] (ATP-dephosphorylating) inhibitors EC 2.3.3.8 (ATP citrate synthase) inhibitor EC 2.3.3.8 (ATP citrate synthase) inhibitors EC 2.3.3.8 inhibitor EC 2.3.3.8 inhibitors acetyl-CoA:oxaloacetate acetyltransferase (isomerizing, ADP-phosphorylating) inhibitor acetyl-CoA:oxaloacetate acetyltransferase (isomerizing, ADP-phosphorylating) inhibitors adenosine triphosphate citrate lyase inhibitor adenosine triphosphate citrate lyase inhibitors citrate cleavage enzyme inhibitor citrate cleavage enzyme inhibitors citrate-ATP lyase inhibitor citrate-ATP lyase inhibitors citric cleavage enzyme inhibitor citric cleavage enzyme inhibitors EC 2.3.3.8 (ATP citrate synthase) inhibitor EC 3.4.21.36 (pancreatic elastase) inhibitor EC 3.4.21.36 (pancreatic elastase) inhibitors EC 3.4.21.36 inhibitor EC 3.4.21.36 inhibitors elastase inhibitor elastase inhibitors elaszym inhibitor elaszym inhibitors pancreatic elastase (EC 3.4.21.36) inhibitor pancreatic elastase (EC 3.4.21.36) inhibitors pancreatic elastase I inhibitor pancreatic elastase I inhibitors pancreatic elastase inhibitor pancreatic elastase inhibitors pancreatopeptidase E inhibitor pancreatopeptidase E inhibitors serine elastase inhibitor serine elastase inhibitors EC 3.4.21.36 (pancreatic elastase) inhibitor chemokine receptor 2 antagonist C-C chemokine receptor type 2 antagonist C-C chemokine receptor type 2 antagonists CCR-2 antagonist CCR-2 antagonists CCR2 antagonist CCR2 antagonists CD192 antagonist CD192 antagonists CKR-2B antagonist CKR-2B antagonists chemokine receptor 2 antagonists chemokine receptor 2 antagonist SERCA activator EC 7.2.2.10 activator EC 7.2.2.10 activators SERCA activators Sarcoplasmic/Endoplasmic Reticulum Calcium-ATPase activator Sarcoplasmic/Endoplasmic Reticulum Calcium-ATPase activators SERCA activator electron donor Elektronendonator donneur d'electron electron donor electron donor acceptor A Acceptor Akzeptor Hydrogen-acceptor Oxidized donor accepteur acceptor topoisomerase II inhibitor topoisomerase II inhibitor MAIT cell agonist MAIT cell agonists mucosal associated invariant T cell agonist mucosal associated invariant T cell agonists MAIT cell agonist G-15 (3Ar,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline GPER antagonist G-15 G-1 1-(4-(6-Bromobenzo[1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)-ethanone GPER agonist G-1 EC 3.4.21.75 (furin) inhibitor EC 3.4.21.75 (furin) inhibitors EC 3.4.21.75 inhibitor EC 3.4.21.75 inhibitors PACE inhibitor PACE inhibitors PC1 inhibitor PC1 inhibitors SPC3 inhibitor SPC3 inhibitors dibasic processing enzyme inhibitor dibasic processing enzyme inhibitors furin convertase inhibitor furin convertase inhibitors furin inhibitor furin inhibitors paired basic amino acid cleaving enzyme inhibitor paired basic amino acid cleaving enzyme inhibitors paired basic amino acid converting enzyme inhibitor paired basic amino acid converting enzyme inhibitors prohormone convertase inhibitor prohormone convertase inhibitors proprotein convertase inhibitor proprotein convertase inhibitors serine proteinase PACE inhibitor serine proteinase PACE inhibitors EC 3.4.21.75 (furin) inhibitor EC 2.4.1.109 (dolichyl-phosphate-mannose-protein mannosyltransferase) inhibitor EC 2.4.1.109 (dolichyl-phosphate-mannose-protein mannosyltransferase) inhibitors EC 2.4.1.109 inhibitor EC 2.4.1.109 inhibitors PMT inhibitor PMT inhibitors dolichol phosphomannose-protein mannosyltransferase inhibitor dolichol phosphomannose-protein mannosyltransferase inhibitors dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase inhibitor dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase inhibitors dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase inhibitor dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase inhibitors dolichyl-phosphate-mannose--protein mannosyltransferase inhibitor dolichyl-phosphate-mannose--protein mannosyltransferase inhibitors protein O-D-mannosyltransferase inhibitor protein O-D-mannosyltransferase inhibitors EC 2.4.1.109 (dolichyl-phosphate-mannose-protein mannosyltransferase) inhibitor Furafylline 3-(uran-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione Furafylline EC 3.4.23.15 (renin) inhibitor EC 3.4.23.15 (renin) inhibitors EC 3.4.23.15 inhibitor EC 3.4.23.15 inhibitors angiotensin-forming enzyme inhibitor angiotensin-forming enzyme inhibitors angiotensinogenase inhibitor angiotensinogenase inhibitors renin inhibitor renin inhibitors EC 3.4.23.15 (renin) inhibitor copper chelator copper chelate copper chelating agent copper chelating agents copper chelator copper chelators copper chelator neuropilin receptor antagonist NRP antagonist NRP antagonists neuropilin receptor antagonists neuropilin receptor antagonist kappa-opioid receptor antagonist kappa-opioid antagonist kappa-opioid antagonists kappa-opioid receptor antagonists kappa-opioid receptor antagonist piscicide piscicides piscicide ovicide ovicides ovicide CPSF3 inhibitor CPSF-73 inhibitor CPSF-73 inhibitors CPSF3 inhibitors CPSF73 inhibitor CPSF73 inhibitors cleavage and polyadenylation specific factor 3 inhibitor cleavage and polyadenylation specific factor 3 inhibitors cleavage and polyadenylation specificity factor 73 KDa subunit inhibitor cleavage and polyadenylation specificity factor 73 KDa subunit inhibitors cleavage and polyadenylation specificity factor subunit 3 inhibitor cleavage and polyadenylation specificity factor subunit 3 inhibitors CPSF3 inhibitor EC 6.1.1.6 (lysine--tRNA ligase) inhibitor EC 6.1.1.6 (lysine--tRNA ligase) inhibitors EC 6.1.1.6 inhibitor EC 6.1.1.6 inhibitors L-lysine-transfer RNA ligase inhibitor L-lysine-transfer RNA ligase inhibitors L-lysine:tRNA(Lys) ligase (AMP-forming) inhibitor L-lysine:tRNA(Lys) ligase (AMP-forming) inhibitors LysRS inhibitor LysRS inhibitors lysine translase inhibitor lysine translase inhibitors lysine--tRNA ligase inhibitor lysine--tRNA ligase inhibitors lysine-tRNA synthetase inhibitor lysine-tRNA synthetase inhibitors lysyl-tRNA synthetase inhibitor lysyl-tRNA synthetase inhibitors lysyl-transfer RNA synthetase inhibitor lysyl-transfer RNA synthetase inhibitors lysyl-transfer ribonucleate synthetase inhibitor lysyl-transfer ribonucleate synthetase inhibitors EC 6.1.1.6 (lysine--tRNA ligase) inhibitor EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitors EZH2 inhibitor EZH2 inhibitors EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor necroptosis inhibitor necroptosis inhibitors necroptosis inhibitor EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor 3D polymerase inhibitor 3D polymerase inhibitors EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitors EC 2.7.7.48 inhibitor EC 2.7.7.48 inhibitors PB1 proteins inhibitor PB1 proteins inhibitors PB2 proteins inhibitor PB2 proteins inhibitors Q-beta replicase inhibitor Q-beta replicase inhibitors RDRP inhibitor RDRP inhibitors RNA nucleotidyltransferase (RNA-directed) inhibitor RNA nucleotidyltransferase (RNA-directed) inhibitors RNA replicase inhibitor RNA replicase inhibitors RNA synthetase inhibitor RNA synthetase inhibitors RNA transcriptase inhibitor RNA transcriptase inhibitors RNA-dependent RNA polymerase inhibitor RNA-dependent RNA polymerase inhibitors RNA-dependent RNA replicase inhibitor RNA-dependent RNA replicase inhibitors RNA-dependent ribonucleate nucleotidyltransferase inhibitor RNA-dependent ribonucleate nucleotidyltransferase inhibitors RNA-directed RNA polymerase inhibitor RNA-directed RNA polymerase inhibitors phage f2 replicase inhibitor phage f2 replicase inhibitors polymerase L inhibitor polymerase L inhibitors ribonucleic acid replicas inhibitor ribonucleic acid replicas inhibitors ribonucleic acid-dependent ribonucleate nucleotidyltransferase inhibitor ribonucleic acid-dependent ribonucleate nucleotidyltransferase inhibitors ribonucleic acid-dependent ribonucleic acid polymeras inhibitor ribonucleic acid-dependent ribonucleic acid polymeras inhibitors ribonucleic replicase inhibitor ribonucleic replicase inhibitors ribonucleic synthetase inhibitor ribonucleic synthetase inhibitors EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor antiamoebic agent amebicide amebicides amoebicide amoebicides anti-amoebic agent anti-amoebic agents anti-amoebic drug anti-amoebic drugs antiamoebic antiamoebic agents antiamoebic drug antiamoebic drugs antiamoebics antiamoebic agent EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitors EC 2.1.1.348 inhibitor EC 2.1.1.348 inhibitors METTL14 inhibitor METTL14 inhibitors METTL3 inhibitor METTL3 inhibitors EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor EC 2.6.1.11 (acetylornithine transaminase) inhibitor 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase inhibitor 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase inhibitors ACOAT inhibitor ACOAT inhibitors EC 2.6.1.11 (acetylornithine transaminase) inhibitors EC 2.6.1.11 inhibitor EC 2.6.1.11 inhibitors N(2)-acetyl-L-ornithine:2-oxoglutarate aminotransferase inhibitor N(2)-acetyl-L-ornithine:2-oxoglutarate aminotransferase inhibitors N(2)-acetylornithine 5-transaminase inhibitor N(2)-acetylornithine 5-transaminase inhibitors N-acetylornithine aminotransferase inhibitor N-acetylornithine aminotransferase inhibitors N-acetylornithine-delta-transaminase inhibitor N-acetylornithine-delta-transaminase inhibitors acetylornithine 5-aminotransferase inhibitor acetylornithine 5-aminotransferase inhibitors acetylornithine aminotransferase inhibitor acetylornithine aminotransferase inhibitors acetylornithine delta-transaminase inhibitor acetylornithine delta-transaminase inhibitors acetylornithine transaminase inhibitor acetylornithine transaminase inhibitors succinylornithine aminotransferase inhibitor succinylornithine aminotransferase inhibitors EC 2.6.1.11 (acetylornithine transaminase) inhibitor antimicrobial cosmetic preservative antimicrobial cosmetic preservatives antimicrobial cosmetic preservative ferroptosis inhibitor ferroptosis inhibitors ferroptosis inhibitor ferroptosis inducer ferroptosis inducers ferroptosis inducer EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitors EC 3.1.3.25 inhibitor EC 3.1.3.25 inhibitors IMPase inhibitor IMPase inhibitors L-myo-inositol-1-phosphate phosphatase inhibitor L-myo-inositol-1-phosphate phosphatase inhibitors inositol 1-phosphatase inhibitor inositol 1-phosphatase inhibitors inositol monophosphatase inhibitor inositol monophosphatase inhibitors inositol monophosphate phosphatase inhibitor inositol monophosphate phosphatase inhibitors inositol phosphatase inhibitor inositol phosphatase inhibitors inositol phosphate phosphatase inhibitor inositol phosphate phosphatase inhibitors inositol-1(or 4)-monophosphatase inhibitor inositol-1(or 4)-monophosphatase inhibitors inositol-phosphate phosphatase inhibitor inositol-phosphate phosphatase inhibitors myo-inositol 1-phosphatase inhibitor myo-inositol 1-phosphatase inhibitors myo-inositol monophosphatase inhibitor myo-inositol monophosphatase inhibitors myo-inositol-1(or 4)-monophosphatase inhibitor myo-inositol-1(or 4)-monophosphatase inhibitors myo-inositol-1(or 4)-phosphate phosphohydrolase inhibitor myo-inositol-1(or 4)-phosphate phosphohydrolase inhibitors myo-inositol-1-phosphatase inhibitor myo-inositol-1-phosphatase inhibitors EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor voltage-dependent anion channel inhibitor VDAC blocker VDAC blockers VDAC inhibitor VDAC inhibitors voltage-dependent anion channel blocker voltage-dependent anion channel blockers voltage-dependent anion channel inhibitors voltage-dependent anion-selective channel blocker voltage-dependent anion-selective channel blockers voltage-dependent anion-selective channel inhibitor voltage-dependent anion-selective channel inhibitors voltage-dependent anion channel inhibitor thioredoxin inhibitor TRX inhibitor TRX inhibitors TRX1 inhibitor TRX1 inhibitors TXN inhibitor TXN inhibitors thioredoxin inhibitors thioredoxin inhibitor testosterone 17beta-Hydroxy-4-androsten-3-one 17beta-hydroxy-4-androsten-3-one 17beta-hydroxyandrost-4-en-3-one 4-androsten-17beta-ol-3-one Androderm TESTOSTERONE Testosteron Testosterone testosterona testosterone testosteronum testosterone hydrogen donor AH2 Donor Hydrogen-donor Reduced acceptor hydrogen donor EC 1.11.1.9 (glutathione peroxidase) inhibitor EC 1.11.1.9 (glutathione peroxidase) inhibitors EC 1.11.1.9 inhibitor EC 1.11.1.9 inhibitors GSH peroxidase inhibitor GSH peroxidase inhibitors glutathione peroxidase inhibitor glutathione peroxidase inhibitors reduced glutathione peroxidase inhibitor reduced glutathione peroxidase inhibitors selenium-glutathione peroxidase inhibitor selenium-glutathione peroxidase inhibitors EC 1.11.1.9 (glutathione peroxidase) inhibitor actin polymerisation inducer actin polymerisation enhancer actin polymerisation enhancers actin polymerisation inducers inducer of actin polymerization inducers of actin polymerization actin polymerisation inducer geroprotector anti-aging agent anti-aging agents anti-aging drug anti-aging drugs geroprotective agent geroprotective agents geroprotectors geroprotector ferroptosis suppressor protein 1 inhibitor AIFM2 inhibitor AIFM2 inhibitors FSP1 inhibitor FSP1 inhibitors apoptosis-inducing factor mitochondria-associated 2 inhibitor apoptosis-inducing factor mitochondria-associated 2 inhibitors ferroptosis suppressor protein 1 inhibitors ferroptosis suppressor protein 1 inhibitor electron acceptor Elektronenakzeptor Oxidized donor electron acceptor electron acceptor EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitors EC 2.7.11.2 inhibitor EC 2.7.11.2 inhibitors PDH kinase inhibitor PDH kinase inhibitors PDHK inhibitor PDHK inhibitors PDK inhibitor PDK inhibitors PDK1 inhibitor PDK1 inhibitors PDK2 inhibitor PDK2 inhibitors PDK3 inhibitor PDK3 inhibitors PDK4 inhibitor PDK4 inhibitors STK1 inhibitor STK1 inhibitors [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitors pyruvate dehydrogenase (acetyl-transferring) kinase inhibitor pyruvate dehydrogenase (acetyl-transferring) kinase inhibitors pyruvate dehydrogenase kinase (phosphorylating) inhibitor pyruvate dehydrogenase kinase (phosphorylating) inhibitors pyruvate dehydrogenase kinase activator protein inhibitor pyruvate dehydrogenase kinase activator protein inhibitors pyruvate dehydrogenase kinase inhibitor pyruvate dehydrogenase kinase inhibitors EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor somatostatin receptor agonist SRIF agonist SRIF agonists SS-R agonist SS-R agonists SSR agonist SSR agonists SSTR agonist SSTR agonists somatostatin receptor agonists somatostatin receptor agonist donor Donator Donor donneur donor (S)-Mephenytoin (5S)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione (S)-Mephenytoin neoantigen neoantigens neoantigen EC 2.3.2.52 (beta-N-acetylhexosaminidase) inhibitor EC 2.3.2.52 (beta-N-acetylhexosaminidase) inhibitors EC 3.2.1.52 inhibitor EC 3.2.1.52 inhibitors N-acetyl-beta-D-hexosaminidase inhibitor N-acetyl-beta-D-hexosaminidase inhibitors N-acetyl-beta-hexosaminidase inhibitor N-acetyl-beta-hexosaminidase inhibitors N-acetylhexosaminidase inhibitor N-acetylhexosaminidase inhibitors beta-D-N-acetylhexosaminidase inhibitor beta-D-N-acetylhexosaminidase inhibitors beta-D-hexosaminidase inhibitor beta-D-hexosaminidase inhibitors beta-N-acetyl-D-hexosaminidase inhibitor beta-N-acetyl-D-hexosaminidase inhibitors beta-N-acetylglucosaminidase inhibitor beta-N-acetylglucosaminidase inhibitors beta-N-acetylhexosaminidase inhibitor beta-N-acetylhexosaminidase inhibitors beta-acetylaminodeoxyhexosidase inhibitor beta-acetylaminodeoxyhexosidase inhibitors beta-acetylhexosaminidinase inhibitor beta-acetylhexosaminidinase inhibitors beta-hexosaminidase inhibitor beta-hexosaminidase inhibitors hexosaminidase A inhibitor hexosaminidase A inhibitors hexosaminidase inhibitor hexosaminidase inhibitors EC 2.3.2.52 (beta-N-acetylhexosaminidase) inhibitor EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor CA4H inhibitor CA4H inhibitors EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitors EC 1.14.14.91 inhibitor EC 1.14.14.91 inhibitors cinnamate 4-hydroxylase inhibitor cinnamate 4-hydroxylase inhibitors cinnamate 4-monooxygenase inhibitor cinnamate 4-monooxygenase inhibitors cinnamate hydroxylase inhibitor cinnamate hydroxylase inhibitors cinnamic 4-hydroxylase inhibitor cinnamic 4-hydroxylase inhibitors cinnamic acid 4-hydroxylase inhibitor cinnamic acid 4-hydroxylase inhibitors cinnamic acid 4-monooxygenase inhibitor cinnamic acid 4-monooxygenase inhibitors cinnamic acid p-hydroxylase inhibitor cinnamic acid p-hydroxylase inhibitors cytochrome P450 cinnamate 4-hydroxylase inhibitor cytochrome P450 cinnamate 4-hydroxylase inhibitors t-cinnamic acid hydroxylase inhibitor t-cinnamic acid hydroxylase inhibitors trans-cinnamate 4-hydroxylase inhibitor trans-cinnamate 4-hydroxylase inhibitors trans-cinnamate 4-monooxygenase inhibitor trans-cinnamate 4-monooxygenase inhibitors trans-cinnamic acid 4-hydroxylase inhibitor trans-cinnamic acid 4-hydroxylase inhibitors EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor EC 3.4.21.61 (kexin) inhibitor EC 3.4.21.61 (kexin) inhibitors EC 3.4.21.61 inhibitor EC 3.4.21.61 inhibitors Kex 2p proteinase inhibitor Kex 2p proteinase inhibitors Kex2 endopeptidase inhibitor Kex2 endopeptidase inhibitors Kex2 endoprotease inhibitor Kex2 endoprotease inhibitors Kex2 endoproteinase inhibitor Kex2 endoproteinase inhibitors Kex2 protease inhibitor Kex2 protease inhibitors Kex2 proteinase inhibitor Kex2 proteinase inhibitors Kex2-like endoproteinase inhibitor Kex2-like endoproteinase inhibitors Kex2-like precursor protein processing endoprotease inhibitor Kex2-like precursor protein processing endoprotease inhibitors andrenorphin-Gly-generating enzyme inhibitor andrenorphin-Gly-generating enzyme inhibitors endoproteinase Kex2p inhibitor endoproteinase Kex2p inhibitors gene KEX2 dibasic proteinase inhibitor gene KEX2 dibasic proteinase inhibitors kexin inhibitor kexin inhibitors paired-basic endopeptidase inhibitor paired-basic endopeptidase inhibitors prohormone-processing KEX2 proteinase inhibitor prohormone-processing KEX2 proteinase inhibitors prohormone-processing endoprotease inhibitor prohormone-processing endoprotease inhibitors prohormone-processing proteinase inhibitor prohormone-processing proteinase inhibitors proprotein convertase inhibitor proprotein convertase inhibitors protease KEX2 inhibitor protease KEX2 inhibitors proteinase Kex2p inhibitor proteinase Kex2p inhibitors proteinase yscF inhibitor proteinase yscF inhibitors yeast KEX2 protease inhibitor yeast KEX2 protease inhibitors EC 3.4.21.61 (kexin) inhibitor PAR2 negative allosteric modulator PAR2 negative allosteric modulator protease-activated receptor-2 antagonist G-protein coupled receptor 11 antagonist G-protein coupled receptor 11 antagonists GPR11 antagonist GPR11 antagonists PAR-2 antagonist PAR-2 antagonists PAR2 antagonist PAR2 antagonists coagulation factor II (thrombin) receptor-like 1 antagonist coagulation factor II (thrombin) receptor-like 1 antagonists protease-activated receptor 2 antagonist protease-activated receptor 2 antagonists protease-activated receptor-2 antagonists protease-activated receptor-2 antagonist sigma receptor modulator sigma receptor modulators sigma-receptor modulator sigma-receptor modulators sigma receptor modulator sigma-2 receptor agonist sigma 2 receptor agonist sigma 2 receptor agonists sigma-2 receptor agonists sigma2 receptor agonist sigma2 receptor agonists sigma2R agonist sigma2R agonists sigma-2 receptor agonist ceramide mimetic ceramide mimetics ceramide mimetic EC 3.2.1.24 (alpha-mannosidase) inhibitor 1,2-alpha-D-mannosidase inhibitor 1,2-alpha-D-mannosidase inhibitors 1,2-alpha-mannosidase inhibitor 1,2-alpha-mannosidase inhibitors EC 3.2.1.24 (alpha-mannosidase) inhibitors EC 3.2.1.24 inhibitor EC 3.2.1.24 inhibitors alpha-D-mannopyranosidase inhibitor alpha-D-mannopyranosidase inhibitors alpha-D-mannosidase inhibitor alpha-D-mannosidase inhibitors alpha-mannosidase inhibitor alpha-mannosidase inhibitors exo-alpha-mannosidase inhibitor exo-alpha-mannosidase inhibitors p-nitrophenyl-alpha-mannosidase inhibitor p-nitrophenyl-alpha-mannosidase inhibitors EC 3.2.1.24 (alpha-mannosidase) inhibitor CB1 receptor agonist CB1 receptor agonist CB1 receptor agonists CB1R agonist CB1R agonists cannabinoid receptor 1 agonist cannabinoid receptor 1 agonists cannabinoid receptor type 1 agonist cannabinoid receptor type 1 agonists type 1 cannabinoid receptor agonist type 1 cannabinoid receptor agonists CB1 receptor agonist elicitor elicitors elicitor EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitor E1 inhibitor E1 inhibitors E1 ubiquitin-activating enzyme inhibitor E1 ubiquitin-activating enzyme inhibitors EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitors EC 6.2.1.45 inhibitor EC 6.2.1.45 inhibitors ubiquitin activating enzyme inhibitor ubiquitin activating enzyme inhibitors ubiquitin-activating enzyme E1 inhibitor ubiquitin-activating enzyme E1 inhibitors EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitor neurokinin-1 receptor agonist NK-1 receptor agonist NK-1 receptor agonists NK1 receptor agonist NK1 receptor agonists neurokinin-1 receptor agonists neurokinin-1 receptor agonist protease-activated receptor-1 agonist PAR-1 agonist PAR-1 agonists PAR-1 receptor agonist PAR-1 receptor agonists PAR1 agonist PAR1 agonists coagulation factor II (thrombin) receptor agonist coagulation factor II (thrombin) receptor agonists coagulation factor II receptor agonist coagulation factor II receptor agonists coagulation factor II thrombin receptor agonist coagulation factor II thrombin receptor agonists protease activated receptor 1 agonist protease activated receptor 1 agonists protease-activated receptor 1 agonist protease-activated receptor 1 agonists protease-activated receptor-1 agonists proteinase-activated receptor 1 agonist proteinase-activated receptor 1 agonists protease-activated receptor-1 agonist piezo1 agonist PIEZO1 agonist PIEZO1 agonists piezo type mechanosensitive ion channel component 1 agonist piezo type mechanosensitive ion channel component 1 agonists piezo-type mechanosensitive ion channel component 1 agonist piezo-type mechanosensitive ion channel component 1 agonists piezo1 agonists piezo1 agonist mitochondrial calcium uniporter inhibitor MCU inhibitor MCU inhibitors mitochondrial calcium uniporter blocker mitochondrial calcium uniporter blockers mitochondrial calcium uniporter inhibitors mitochondrial calcium uniporter inhibitor gastric inhibitory polypeptide receptor agonist GIP agonist GIP agonists GIP receptor agonist GIP receptor agonists GIP-R agonist GIP-R agonists GIPR agonist GIPR agonists gastric inhibitory polypeptide receptor agonists glucose-dependent insulinotropic polypeptide receptor agonist glucose-dependent insulinotropic polypeptide receptor agonists gastric inhibitory polypeptide receptor agonist T-type calcium channel blocker T-type calcium channel antagonist T-type calcium channel antagonists T-type calcium channel blockers T-type calcium channel blocker aquaretic aquaretic agent aquaretic agents aquaretics aquaretic antimyopathic agent antimyopathic agents antimyopathic drug antimyopathic drugs antimyopathic agent NOD1 agonist CARD4 agonist CARD4 agonists CLR7.1 agonist CLR7.1 agonists NOD1 agonists caspase recruitment domain-containing protein 4 agonist caspase recruitment domain-containing protein 4 agonists nucleotide binding oligomerization domain containing 1 agonist nucleotide binding oligomerization domain containing 1 agonists nucleotide-binding oligomerization domain-containing protein 1 agonist nucleotide-binding oligomerization domain-containing protein 1 agonists NOD1 agonist activator activators activator enzyme activator enzyme activators enzyme activator Grace_C1_2023 Hezinglila Grace compound 1 Grace_C1_2023 EC 2.6.1.13 (ornithine aminotransferase) inhibitor EC 2.6.1.13 (ornithine aminotransferase) inhibitors EC 2.6.1.13 inhibitor EC 2.6.1.13 inhibitors L-ornithine 5-aminotransferase inhibitor L-ornithine 5-aminotransferase inhibitors L-ornithine aminotransferase inhibitor L-ornithine aminotransferase inhibitors L-ornithine:alpha-ketoglutarate -aminotransferase inhibitor L-ornithine:alpha-ketoglutarate -aminotransferase inhibitors OAT inhibitor OAT inhibitors ornithine 5-aminotransferase inhibitor ornithine 5-aminotransferase inhibitors ornithine aminotransferase inhibitor ornithine aminotransferase inhibitors ornithine delta-transaminase inhibitor ornithine delta-transaminase inhibitors ornithine transaminase inhibitor ornithine transaminase inhibitors ornithine--oxo-acid transaminase inhibitor ornithine--oxo-acid transaminase inhibitors ornithine-2-oxoacid aminotransferase inhibitor ornithine-2-oxoacid aminotransferase inhibitors ornithine-alpha-ketoglutarate aminotransferase inhibitor ornithine-alpha-ketoglutarate aminotransferase inhibitors ornithine-keto acid aminotransferase inhibitor ornithine-keto acid aminotransferase inhibitors ornithine-keto acid transaminase inhibitor ornithine-keto acid transaminase inhibitors ornithine-ketoglutarate aminotransferase inhibitor ornithine-ketoglutarate aminotransferase inhibitors ornithine-oxo acid aminotransferase inhibitor ornithine-oxo acid aminotransferase inhibitors ornithine:alpha-oxoglutarate transaminase inhibitor ornithine:alpha-oxoglutarate transaminase inhibitors EC 2.6.1.13 (ornithine aminotransferase) inhibitor insulin-like growth factor-binding protein inhibitor IGFBP inhibitor IGFBP inhibitors insulin-like growth factor-binding protein inhibitors insulin-like growth factor-binding protein inhibitor EC 2.7.12.1 (dual-specificity kinase) inhibitor ADK1 inhibitor ADK1 inhibitors Arabidopsis dual specificity kinase 1 inhibitor Arabidopsis dual specificity kinase 1 inhibitors CLK1 inhibitor CLK1 inhibitors EC 2.7.12.1 (dual-specificity kinase) inhibitors EC 2.7.12.1 inhibitor EC 2.7.12.1 inhibitors Mps1p inhibitor Mps1p inhibitors dDYRK2 inhibitor dDYRK2 inhibitors dual-specificity kinase inhibitor dual-specificity kinase inhibitors EC 2.7.12.1 (dual-specificity kinase) inhibitor PCNA inhibitor PCNA inhibitors proliferating cell nuclear antigen inhibitor proliferating cell nuclear antigen inhibitors PCNA inhibitor sphingosine-1-phosphate receptor 2 antagonist EDG-5 antagonist EDG-5 antagonists EDG5 antagonist EDG5 antagonists S1P2 antagonist S1P2 antagonists S1PR2 antagonist S1PR2 antagonists sphingosine-1-phosphate receptor 2 antagonists sphingosine-1-phosphate receptor 2 antagonist EC 3.5.3.1 (arginase) inhibitor EC 3.5.3.1 (arginase) inhibitors EC 3.5.3.1 inhibitor EC 3.5.3.1 inhibitors L-arginase inhibitor L-arginase inhibitors arginase inhibitor arginase inhibitors arginine amidinase inhibitor arginine amidinase inhibitors arginine transamidinase inhibitor arginine transamidinase inhibitors canavanase inhibitor canavanase inhibitors EC 3.5.3.1 (arginase) inhibitor EC 3.5.3.* (non-peptide linear amidine C-N hydrolase) inhibitor EC 3.5.3.* (non-peptide linear amidine C-N hydrolase) inhibitors EC 3.5.3.* inhibitor EC 3.5.3.* inhibitors non-peptide linear amidine C-N hydrolase (EC 3.5.3.*) inhibitor non-peptide linear amidine C-N hydrolase (EC 3.5.3.*) inhibitors EC 3.5.3.* (non-peptide linear amidine C-N hydrolase) inhibitor calcitonin gene-related peptide receptor antagonist CGRP antagonist CGRP antagonists calcitonin gene-related peptide receptor antagonists calcitonin gene-related peptide receptor antagonist Rac1 inhibitor Rac-1 inhibitor Rac-1 inhibitors Rac1 inhibitors Ras-related C3 botulinum toxin substrate 1 inhibitor Ras-related C3 botulinum toxin substrate 1 inhibitors Rac1 inhibitor EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor 3-enol-pyruvoylshikimate-5-phosphate synthase inhibitor 3-enol-pyruvoylshikimate-5-phosphate synthase inhibitors 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) inhibitor 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) inhibitors 3-phosphoshikimate 1-carboxyvinyltransferase inhibitor 3-phosphoshikimate 1-carboxyvinyltransferase inhibitors 5-enolpyruvylshikimate-3-phosphate synthase inhibitor 5-enolpyruvylshikimate-3-phosphate synthase inhibitors EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitors EC 2.5.1.19 inhibitor EC 2.5.1.19 inhibitors EPSP synthase inhibitor EPSP synthase inhibitors phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase inhibitor phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase inhibitors EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor ATP synthase inhibitor ATP synthase inhibitor acaricide Akarizid Akarizide acaricides miticide acaricide EC 2.2.1.6 (acetolactate synthase) inhibitor EC 2.2.1.6 (acetolactate synthase) inhibitors EC 2.2.1.6 inhibitor EC 2.2.1.6 inhibitors acetohydroxy acid synthetase inhibitor acetohydroxy acid synthetase inhibitors acetohydroxyacid synthase inhibitor acetohydroxyacid synthase inhibitors acetolactate pyruvate-lyase (carboxylating) inhibitor acetolactate pyruvate-lyase (carboxylating) inhibitors acetolactate synthase (EC 2.2.1.6) inhibitor acetolactate synthase (EC 2.2.1.6) inhibitors acetolactate synthase inhibitor acetolactate synthase inhibitors acetolactic synthetase inhibitor acetolactic synthetase inhibitors alpha-acetohydroxy acid synthetase inhibitor alpha-acetohydroxy acid synthetase inhibitors alpha-acetohydroxyacid synthase inhibitor alpha-acetohydroxyacid synthase inhibitors alpha-acetolactate synthase inhibitor alpha-acetolactate synthase inhibitors alpha-acetolactate synthetase inhibitor alpha-acetolactate synthetase inhibitors pyruvate:pyruvate acetaldehydetransferase (decarboxylating) inhibitor pyruvate:pyruvate acetaldehydetransferase (decarboxylating) inhibitors EC 2.2.1.6 (acetolactate synthase) inhibitor alicyclic antibiotics alicyclic antibiotics aliphatic antibiotics aliphatic antibiotics alkylating agent alkylating agent alpha-1-microglobulin-Ig alpha complex chromophores alpha-1-microglobulin-Ig alpha complex chromophores amino acid derivative antibiotics amino acid derivative antibiotics antiauxins antiauxins antifeedant antifeedants antifeedant antioxidant antioxidants antioxydant antoxidant antioxidant antiviral agent anti-viral agent anti-viral agents antiviral antiviral agents antivirals antiviral agent auxin auxins auxin base Base Base1 Base2 Basen Nucleobase base bases base phytogenic insecticide botanical insecticide botanical insecticides phytogenic insecticides phytogenic insecticide calcium ionophore calcium ionophores calcium ionophore EC 4.2.1.1 (carbonic anhydrase) inhibitor EC 4.2.1.1 (carbonic anhydrase) inhibitors EC 4.2.1.1 inhibitor EC 4.2.1.1 inhibitors anhydrase inhibitor anhydrase inhibitors carbonate anhydrase inhibitor carbonate anhydrase inhibitors carbonate dehydratase inhibitor carbonate dehydratase inhibitors carbonate hydro-lyase (carbon-dioxide-forming) inhibitor carbonate hydro-lyase (carbon-dioxide-forming) inhibitors carbonate hydro-lyase inhibitor carbonate hydro-lyase inhibitors carbonic acid anhydrase inhibitor carbonic acid anhydrase inhibitors carbonic anhydrase (EC 4.2.1.1) inhibitor carbonic anhydrase (EC 4.2.1.1) inhibitors carbonic anhydrase A inhibitor carbonic anhydrase A inhibitors carbonic anhydrase inhibitor carbonic anhydrase inhibitors carboxyanhydrase inhibitor carboxyanhydrase inhibitors EC 4.2.1.1 (carbonic anhydrase) inhibitor chemosterilant chemosterilants chemosterilant chitin synthesis inhibitor chitin synthesis inhibitor chromophore chromophore chromophores chromophore coenzyme coenzyme coenzymes coenzyme cofactor cofactor cofactors cofactor compatible osmolytes compatible osmolytes molecular entity entidad molecular entidades moleculares entite moleculaire molecular entities molecular entity molekulare Entitaet molecular entity cytochrome-b6f complex inhibitor cytochrome-b6f complex inhibitor cytokinin cytokinin defoliant Defoliationsmittel Entlaubungsmittel defoliants defoliant drug drugs medicine drug ecdysone antagonists ecdysone antagonists enzyme inhibitor enzyme inhibitor enzyme inhibitors inhibidor enzimatico inhibidores enzimaticos inhibiteur enzymatique inhibiteurs enzymatiques enzyme inhibitor estradiol estra-1,3,5(10)-triene-3,17-diol oestradiol estradiol ethylene releasers ethylene releasers fat-soluble vitamin (role) fat-soluble vitamin fat-soluble vitamins fettloesliche Vitamine fat-soluble vitamin (role) iron(3+) chelator iron(3+) chelator fungicide fungicides fungicide EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors EC 6.3.1.2 inhibitor EC 6.3.1.2 inhibitors L-glutamate:ammonia ligase (ADP-forming) inhibitor L-glutamate:ammonia ligase (ADP-forming) inhibitors L-glutamine synthetase inhibitor L-glutamine synthetase inhibitors glutamate--ammonia ligase (EC 6.3.1.2) inhibitor glutamate--ammonia ligase (EC 6.3.1.2) inhibitors glutamate--ammonia ligase inhibitor glutamate--ammonia ligase inhibitors glutamine synthetase inhibitor glutamine synthetase inhibitors glutamylhydroxamic synthetase inhibitor glutamylhydroxamic synthetase inhibitors EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor group transfer coenzymes group transfer coenzymes biological role biological function biological role herbicide Herbizid Unkrautbekaempfungsmittel Unkrautvertilgungsmittel Wildkrautbekaempfungsmittel herbicides herbicide hormone endocrine hormones hormone insect attractant insect attractants insect attractant insect growth regulator insect growth regulators insect growth regulator insecticide insecticides insecticide intercalator agente intercalante intercalating agent intercalating agents intercalating ligands intercalators intercalator ionophore ionophore ionophores ionophore iron ionophore iron ionophores iron ionophore jasmonates jasmonates juvenile hormone antagonists juvenile hormone antagonists juvenile hormone mimic juvenile hormone mimic luciferin luciferin metabolite metabolite metabolites primary metabolites secondary metabolites metabolite mitochondrial respiratory-chain inhibitor mitochondrial electron transport chain inhibitors mitochondrial electron-transport chain inhibitor mitochondrial respiratory chain inhibitors mitochondrial respiratory-chain inhibitor mutagen mutagene mutagenes mutagenic agent mutageno mutagenos mutagens mutagen mycotoxin fungal toxins mycotoxins mycotoxin nematicide nematicides nematocide nematocides nematicide neurotransmitter neurotransmitters neurotransmitter neonicotinoid insectide neonicotinoid insectides nicotinoid insectide nicotinoid insectides neonicotinoid insectide nodulation factor NF nod factor nodulation factors nodulation factor nucleoside antibiotic nucleoside antibiotic osmolyte osmolytes osmolyte oxidized luciferins oxidized luciferins pesticide synergist pesticide synergists pesticide synergist pesticide Pestizid Pestizide pesticide pesticides pesticide pheromone ectohormone feromone pheromone pheromones pheromone phosphorus containing antibiotics phosphorus containing antibiotics photosynthetic electron-transport chain inhibitor photosynthetic electron-transport chain inhibitor photosystem-I inhibitor photosystem-I inhibitor photosystem-II inhibitor photosystem-II inhibitor phytoalexin phytoalexins phytoalexin biological pigment pigments biological pigment plant growth regulator plant growth regulators plant growth regulator plant growth stimulator plant growth stimulators plant growth stimulator precocenes precocenes prosthetic group groupe prosthetique prosthetic group prosthetic groups prosthetic group pyrethroid insecticide pyrethroid insecticides pyrethroid insecticide semiochemical semiochemicals semiochemical sideramine sideramine siderophore ferrioxamine ferrioxamines ironophore siderochrome siderochromes siderophore siderophores siderophore amodiaquine 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol Amodiaquine amodiaquina amodiaquine amodiaquinum amodiaquine synthetic auxin synthetic auxins synthetic auxin systemic acquired resistance inducing compounds systemic acquired resistance inducing compounds toxin toxin toxins toxin micronutrient micronutrients trace elements micronutrient volatile oil component essential oil component essential oil components ethereal oil component ethereal oil components volatile oil components volatile oil component water-soluble vitamin (role) wasserloesliche Vitamine water-soluble vitamin water-soluble vitamins water-soluble vitamin (role) xenobiotic organic ethers xenobiotic organic ethers detergent Detergents detergent detergent quinidine (+)-Quinidine (+)-quinidine (8R,9S)-quinidine (9S)-6'-methoxycinchonan-9-ol (R)-(6-methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol (S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol (S)-(6-methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol 6-methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol CIN-QUIN Chinidin Conchinin Kinidin Quinidine alpha-(6-methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol beta-quinine chinidinum conquinine pitayine quinidina quinidine quinidine bupropion 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one Bupropion bupropion vitamin (role) vitamin vitamina vitaminas vitamine vitamines vitamins vitaminum vitamin (role) antitubercular agent antitubercular antitubercular agents antitubercular drug antitubercular drugs tuberculostatic agent antitubercular agent application application molecular messenger chemical messenger molecular messenger antimicrobial agent Antibiotika Antibiotikum antibiotic antibiotics antibiotique antimicrobial antimicrobial agents antimicrobials microbicide microbicides antimicrobial agent antibacterial agent antibacterial agents antibacterials bactericide bactericides antibacterial agent nutrient nutrients nutrient agrochemical agrichemical agrichemicals agricultural chemicals agrochemicals agrochemical fertilizer fertiliser fertilizers fertilizer rodenticide rodenticides rodenticide avicide avicides avicide food food material food materials food role foods foodstuff foodstuffs food fuel fuel diagnostic agent diagnostic aid diagnostic agent reagent reactif reactivo reagent reagents reagent molluscicide molluscicides molluscicide macronutrient macronutrients macronutrient surfactant surface active agent surfactant surfactants surfactant lumiphore luminophore lumiphore lumiphore tracer tracer tracer chemical tracer chemical tracer chemical tracer isotopic tracer isotopic tracer isotopic tracer radioactive tracer radioactive tracer radioactive tracer physical tracer physical tracer physical tracer label label label spin label spin label spin label radioactive label radioactive label radioactive label plant growth retardant plant growth inhibitor plant growth inhibitors plant growth retardants plant growth retardant antimetabolite antimetabolite antimetabolites antimetabolite inhibitor inhibidor inhibiteur inhibitor inhibitors inhibitor catalyst Katalysator catalizador catalyseur catalyst catalyst effector effector enzyme modulator effector buffer buffer compound buffer compounds buffer spin probe spin probe spin probe fossil fuel fossil fuel fossil fuel nuclear fuel nuclear fuel nuclear fuel radiopharmaceutical radiopharmaceuticals radiopharmaceutical central nervous system stimulant CNS stimulant analeptic analeptic agent analeptic drug analeptics central nervous system stimulant central stimulant central nervous system stimulant antiinfective agent anti-infective agents anti-infective drugs antiinfective agents antiinfective drug antiinfective agent antiparasitic agent antiparasitic drugs antiparasitics parasiticides antiparasitic agent anthelminthic drug anthelminthic anthelminthics anthelmintic anthelmintics antihelminth antihelmintico vermifuge anthelminthic drug antinematodal drug antinematodal agent antinematodal drugs antinematodals antinematodal drug EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor ACE inhibitor ACE inhibitors DCP inhibitor DCP inhibitors EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitors EC 3.4.15.1 inhibitor EC 3.4.15.1 inhibitors PDH inhibitor PDH inhibitors angiotensin I-converting enzyme inhibitor angiotensin I-converting enzyme inhibitors angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors carboxycathepsin inhibitor carboxycathepsin inhibitors dipeptidase inhibitor dipeptidase inhibitors dipeptide hydrolase inhibitor dipeptide hydrolase inhibitors dipeptidyl carboxypeptidase I inhibitor dipeptidyl carboxypeptidase I inhibitors dipeptidyl carboxypeptidase inhibitor dipeptidyl carboxypeptidase inhibitors endothelial cell peptidyl dipeptidase inhibitor endothelial cell peptidyl dipeptidase inhibitors kininase II inhibitor kininase II inhibitors peptidase P inhibitor peptidase P inhibitors peptidyl dipeptidase A inhibitor peptidyl dipeptidase A inhibitors peptidyl dipeptidase I inhibitor peptidyl dipeptidase I inhibitors peptidyl dipeptidase-4 inhibitor peptidyl dipeptidase-4 inhibitors peptidyl dipeptide hydrolase inhibitor peptidyl dipeptide hydrolase inhibitors peptidyl-dipeptidase A (EC 3.4.15.1) inhibitor peptidyl-dipeptidase A (EC 3.4.15.1) inhibitors peptidyl-dipeptidase A inhibitor peptidyl-dipeptidase A inhibitors peptidyl-dipeptide hydrolase inhibitor peptidyl-dipeptide hydrolase inhibitors peptidyldipeptide hydrolase inhibitor peptidyldipeptide hydrolase inhibitors EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor antidepressant antidepressant drugs antidepressants thymoanaleptics thymoleptic drugs thymoleptics antidepressant central nervous system drug CNS agent CNS drugs central nervous system agents central nervous system drug psychotropic drug psychoactive agent psychoactive drugs psychopharmaceuticals psychotropic drugs psychotropic drug anti-inflammatory drug anti-inflammatory drugs antiinflammatory agent antiinflammatory drug antiinflammatory drugs anti-inflammatory drug tranquilizing drug ataractics tranquilising drug tranquilizing drugs tranquillising agent tranquillizing agents tranquilizing drug anxiolytic drug anti-anxiety agents anti-anxiety drugs anxiolytic agents anxiolytics minor tranquilisers minor tranquilizers minor tranquilizing agents anxiolytic drug non-steroidal anti-inflammatory drug NSAID NSAIDs non-steroidal anti-inflammatory agent non-steroidal anti-inflammatory drugs non-steroidal anti-inflammatory drug antipsychotic agent Neuroleptikum antipsychotic agents antipsychotic drug antipsychotic drugs antipsychotics antipsychotiques grosser Tranquilizer major tranquilizers major tranquilizing agents neuroleptic neuroleptic agents neuroleptics neuroleptique neuroleptiques antipsychotic agent antimanic drug antimanic agent antimanic drugs antimanics antimanic drug analgesic analgesic non-narcotic analgesic non-narcotic analgesic opioid analgesic narcotic narcotic analgesic narcotic analgesics narcotics opioid analgesics opioid analgesic EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor CoA-independent aldehyde dehydrogenase inhibitor CoA-independent aldehyde dehydrogenase inhibitors EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitor EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitors EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitors EC 1.2.1.3 inhibitor EC 1.2.1.3 inhibitors NAD-aldehyde dehydrogenase inhibitor NAD-aldehyde dehydrogenase inhibitors NAD-dependent 4-hydroxynonenal dehydrogenase inhibitor NAD-dependent 4-hydroxynonenal dehydrogenase inhibitors NAD-dependent aldehyde dehydrogenase inhibitor NAD-dependent aldehyde dehydrogenase inhibitors NAD-linked aldehyde dehydrogenase inhibitor NAD-linked aldehyde dehydrogenase inhibitors aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitor aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitors aldehyde dehydrogenase (NAD(+)) inhibitor aldehyde dehydrogenase (NAD(+)) inhibitors aldehyde dehydrogenase (NAD) inhibitor aldehyde dehydrogenase (NAD) inhibitors aldehyde dehydrogenase inhibitor aldehyde dehydrogenase inhibitors m-methylbenzaldehyde dehydrogenase inhibitor m-methylbenzaldehyde dehydrogenase inhibitors propionaldehyde dehydrogenase inhibitor propionaldehyde dehydrogenase inhibitors EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor central nervous system depressant CNS depressants central nervous system depressants central nervous system depressant antipyretic anti-pyretic antipyretic androgen antagonist antiandrogen androgen antagonist diuretic diuretics diuretic hallucinogen hallucinogenic agents hallucinogenic drugs hallucinogens psychedelic agents psychedelics hallucinogen beta-adrenergic agonist beta-adrenergic agonists beta-adrenergic receptor agonist beta-adrenoceptor agonists beta-adrenergic agonist bronchodilator agent bronchodilator bronchodilator agents broncholytic agent bronchodilator agent sympathomimetic agent sympathomimetic sympathomimetics sympathomimetic agent hypoglycemic agent antidiabetic antihyperglycemic antihyperglycemic agent antihyperglycemic agents antihyperglycemic drug antihyperglycemic drugs antihyperglycemics hypoglycemic agents hypoglycemic drug hypoglycemic drugs hypoglycemic agent beta-adrenergic antagonist beta-adrenergic antagonists beta-adrenergic blocker beta-adrenergic blockers beta-adrenergic receptor blockaders beta-adrenoceptor antagonists beta-blocker beta-blockers beta-adrenergic antagonist EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors (PG)H synthase inhibitor (PG)H synthase inhibitors COX inhibitor EC 1.14.99.1 (cyclooxygenase) inhibitor EC 1.14.99.1 (cyclooxygenase) inhibitors EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors EC 1.14.99.1 inhibitor EC 1.14.99.1 inhibitors PG synthetase inhibitor PG synthetase inhibitors cyclooxygenase (EC 1.14.99.1) inhibitor cyclooxygenase (EC 1.14.99.1) inhibitors cyclooxygenase inhibitor cyclooxygenase inhibitors fatty acid cyclooxygenase inhibitor fatty acid cyclooxygenase inhibitors prostaglandin G/H synthase inhibitor prostaglandin G/H synthase inhibitors prostaglandin endoperoxide synthetase inhibitor prostaglandin endoperoxide synthetase inhibitors prostaglandin synthase inhibitor prostaglandin synthase inhibitors prostaglandin synthetase inhibitor prostaglandin synthetase inhibitors EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor cardiovascular drug cardiovascular agent cardiovascular drugs cardiovascular drug alpha-adrenergic agonist alpha-adrenergic agonists alpha-adrenergic receptor agonist alpha-adrenoceptor agonists alpha-adrenergic agonist EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitors EC 3.1.3.48 inhibitor EC 3.1.3.48 inhibitors PPT-phosphatase inhibitor PPT-phosphatase inhibitors PTP-phosphatase inhibitor PTP-phosphatase inhibitors PTPase inhibitor PTPase inhibitors [phosphotyrosine]protein phosphatase inhibitor [phosphotyrosine]protein phosphatase inhibitors phosphoprotein phosphatase (phosphotyrosine) inhibitor phosphoprotein phosphatase (phosphotyrosine) inhibitors phosphotyrosine histone phosphatase inhibitor phosphotyrosine histone phosphatase inhibitors phosphotyrosine phosphatase inhibitor phosphotyrosine phosphatase inhibitors phosphotyrosine protein phosphatase inhibitor phosphotyrosine protein phosphatase inhibitors phosphotyrosylprotein phosphatase inhibitor phosphotyrosylprotein phosphatase inhibitors protein phosphotyrosine phosphatase inhibitor protein phosphotyrosine phosphatase inhibitors protein tyrosine phosphatase inhibitor protein tyrosine phosphatase inhibitors protein-tyrosine-phosphatase (EC 3.1.3.48) inhibitor protein-tyrosine-phosphatase (EC 3.1.3.48) inhibitors protein-tyrosine-phosphatase inhibitor protein-tyrosine-phosphatase inhibitors protein-tyrosine-phosphate phosphohydrolase inhibitor protein-tyrosine-phosphate phosphohydrolase inhibitors tyrosine O-phosphate phosphatase inhibitor tyrosine O-phosphate phosphatase inhibitors tyrosylprotein phosphatase inhibitor tyrosylprotein phosphatase inhibitors EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor antineoplastic agent anticancer agent anticancer agents antineoplastic antineoplastic agents cytostatic antineoplastic agent flavouring agent flavoring agent flavoring agents flavour enhancer flavour enhancers flavouring agents flavouring agent vasodilator agent vasodilator vasodilator agents vasodilator agent anticonvulsant Antiepileptika Antiepileptikum Antikonvulsiva Antikonvulsivum anti-convulsant anti-convulsants anti-convulsive agent anti-convulsive agents anticonvulsants anticonvulsive agent anticonvulsive agents antiepileptic antiepileptics antiepileptique antiepileptiques anticonvulsant EC 3.5.2.6 (beta-lactamase) inhibitor EC 3.5.2.6 (beta-lactamase) inhibitors EC 3.5.2.6 inhibitor EC 3.5.2.6 inhibitors ampicillinase inhibitor ampicillinase inhibitors beta-lactam hydrolase inhibitor beta-lactam hydrolase inhibitors beta-lactamase (EC 3.5.2.6) inhibitor beta-lactamase (EC 3.5.2.6) inhibitors beta-lactamase A, B, C inhibitor beta-lactamase A, B, C inhibitors beta-lactamase AME I inhibitor beta-lactamase AME I inhibitors beta-lactamase I-III inhibitor beta-lactamase I-III inhibitors beta-lactamase inhibitor beta-lactamase inhibitors cephalosporin-beta-lactamase inhibitor cephalosporin-beta-lactamase inhibitors cephalosporinase inhibitor cephalosporinase inhibitors exopenicillinase inhibitor exopenicillinase inhibitors neutrapen inhibitor neutrapen inhibitors penicillin amido-beta-lactamhydrolase inhibitor penicillin amido-beta-lactamhydrolase inhibitors penicillin beta-lactamase inhibitor penicillin beta-lactamase inhibitors penicillinase I, II inhibitor penicillinase I, II inhibitors penicillinase inhibitor penicillinase inhibitors EC 3.5.2.6 (beta-lactamase) inhibitor EC 1.17.3.2 (xanthine oxidase) inhibitor EC 1.17.3.2 (xanthine oxidase) inhibitors EC 1.17.3.2 inhibitor EC 1.17.3.2 inhibitors Schardinger enzyme inhibitor Schardinger enzyme inhibitors hypoxanthine oxidase inhibitor hypoxanthine oxidase inhibitors hypoxanthine-xanthine oxidase inhibitor hypoxanthine-xanthine oxidase inhibitors hypoxanthine:oxygen oxidoreductase inhibitor hypoxanthine:oxygen oxidoreductase inhibitors xanthine oxidase (EC 1.17.3.2) inhibitor xanthine oxidase (EC 1.17.3.2) inhibitors xanthine oxidase inhibitor xanthine oxidase inhibitors xanthine oxidoreductase inhibitor xanthine oxidoreductase inhibitors xanthine:O2 oxidoreductase inhibitor xanthine:O2 oxidoreductase inhibitors xanthine:oxygen oxidoreductase inhibitor xanthine:oxygen oxidoreductase inhibitors xanthine:xanthine oxidase inhibitor xanthine:xanthine oxidase inhibitors EC 1.17.3.2 (xanthine oxidase) inhibitor adrenergic uptake inhibitor ARI NERI NRI adrenergic reuptake inhibitor adrenergic reuptake inhibitors adrenergic uptake inhibitors norepinephrine reuptake inhibitor norepinephrine reuptake inhibitors adrenergic uptake inhibitor HIV protease inhibitor HIV protease inhibitors HIV protease inhibitor EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor HMG-CoA reductase inhibitor HMG-CoA reductase inhibitors hydroxymethylglutaryl-CoA reductase inhibitor hydroxymethylglutaryl-CoA reductase inhibitors EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor antihypertensive agent antihypertensive antihypertensive agents antihypertensive drug antihypertensive drugs antihypertensive agent histamine agonist histamine agonists histamine agonist antilipemic drug antihyperlipemic antihyperlipemics antihyperlipidaemic agent antihyperlipidaemic agents antihyperlipidaemic drug antihyperlipidaemic drugs antihyperlipidemic antihyperlipidemic agent antihyperlipidemic agents antihyperlipidemic drug antihyperlipidemic drugs antihyperlipidemics antilipemic antilipemic drugs antilipemics hypolipidemic agent hypolipidemic agents lipid-lowering agent lipid-lowering agents lipid-lowering drug lipid-lowering drugs antilipemic drug antiplatyhelmintic drug antiplatyhelmintic agent antiplatyhelmintic drugs antiplatyhelmintic drug xenobiotic Xenobiotic xenobiotic xenobiotic compounds xenobiotics xenobiotic immunosuppressive agent immunosuppressant immunosuppressive agents inmunosupresor immunosuppressive agent sedative hypnotics hypnotics and sedatives sedative drug sedatives sedatives and hypnotics sedative antifungal agent antifungal antifungal agents antifungal drug antifungal drugs antifungals antifungal agent leprostatic drug leprostatic leprostatic agent leprostatic drugs leprostatic drug coccidiostat anticoccidial agent coccidiostats coccidiostat antiprotozoal drug antiprotozoal agent antiprotozoal agents antiprotozoal drugs antiprotozoal drug anticholesteremic drug anticholesteremic anticholesteremic agent anticholesteremic drugs antihypercholesterolemic antihypercholesterolemic agent antihypercholesterolemic agents antihypercholesterolemic drug antihypercholesterolemic drugs antihypercholesterolemics cholesterol inhibitor cholesterol-lowering agent cholesterol-lowering agents cholesterol-lowering drug cholesterol-lowering drugs hypocholesteremic agent anticholesteremic drug uricosuric drug uricosuric agent uricosuric drugs uricosuric drug antirheumatic drug anti-rheumatic drugs antirheumatic agent antirheumatic drugs antirheumatic drug gout suppressant gout suppressants gout suppressant renal agent renal agents renal agent lipoxygenase inhibitor lipooxygenase inhibitor lipoxygenase inhibitors lipoxygenase inhibitor serotonergic agonist 5-HT agonist 5-hydroxytryptamine agonist serotonergic agonists serotonin agonist serotonin agonists serotonergic agonist neurotransmitter agent neurotransmitter agents neurotransmitter agent antimicrobial drug antimicrobial drugs antimicrobial drug antiviral drug anti-viral drug anti-virus drug antiviral drugs antiviral drug antibacterial drug antibacterial drugs antibacterial drug antitreponemal drug antitreponemal agent antitreponemal drugs antitreponemal drug antisyphilitic drug antisyphilitic agent antisyphilitic agents antisyphilitic drugs antisyphilitics antisyphilitic drug acaricide drug acaricide drugs acaricide drug oxytocic oxytocic oxytocic agents oxytocic drugs uterine stimulants oxytocic taurocholate 2-[(3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonate taurocholate taurocholate local anaesthetic Lokalanaesthetikum anesthesique local local anaesthetic local anaesthetics local anesthetics local anaesthetic trypanocidal drug antitrypanosomal agent antitrypanosomal agents antitrypanosomal drug antitrypanosomal drugs trypanocidal drugs trypanocide trypanosomicidal agents trypanocidal drug anabolic agent anabolic agent interferon inducer interferon inducers interferon inducer EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors Aspergillus awamori acid protein phosphatase inhibitor Aspergillus awamori acid protein phosphatase inhibitors BCKDH phosphatase inhibitor BCKDH phosphatase inhibitors EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors EC 3.1.3.16 inhibitor EC 3.1.3.16 inhibitors HMG-CoA reductase phosphatase inhibitor HMG-CoA reductase phosphatase inhibitors branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors calcineurin inhibitor calcineurin inhibitors casein phosphatase inhibitor casein phosphatase inhibitors phosphatase 2A inhibitor phosphatase 2A inhibitors phosphatase 2B inhibitor phosphatase 2B inhibitors phosphatase C-II inhibitor phosphatase C-II inhibitors phosphatase H-II inhibitor phosphatase H-II inhibitors phosphatase I inhibitor phosphatase I inhibitors phosphatase IB inhibitor phosphatase IB inhibitors phosphatase II inhibitor phosphatase II inhibitors phosphatase III inhibitor phosphatase III inhibitors phosphatase IV inhibitor phosphatase IV inhibitors phosphatase SP inhibitor phosphatase SP inhibitors phosphoprotein phosphatase (EC 3.1.3.16) inhibitor phosphoprotein phosphatase (EC 3.1.3.16) inhibitors phosphoprotein phosphatase inhibitor phosphoprotein phosphatase inhibitors phosphoprotein phosphohydrolase inhibitor phosphoprotein phosphohydrolase inhibitors phosphopyruvate dehydrogenase phosphatase inhibitor phosphopyruvate dehydrogenase phosphatase inhibitors phosphospectrin phosphatase inhibitor phosphospectrin phosphatase inhibitors polycation modulated (PCM-) phosphatase inhibitor polycation modulated (PCM-) phosphatase inhibitors protein D phosphatase inhibitor protein D phosphatase inhibitors protein phosphatase inhibitor protein phosphatase inhibitors protein phosphatase-1 inhibitor protein phosphatase-1 inhibitors protein phosphatase-2A inhibitor protein phosphatase-2A inhibitors protein phosphatase-2B inhibitor protein phosphatase-2B inhibitors protein phosphatase-2C inhibitor protein phosphatase-2C inhibitors protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors protein serine/threonine phosphatase inhibitor protein serine/threonine phosphatase inhibitors serine/threonine specific protein phosphatase inhibitor serine/threonine specific protein phosphatase inhibitors EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor diagnostic imaging agent diagnostic imaging agent MRI contrast agent MRI contrast agent radioactive imaging agent radioactive imaging agent ultrasound contrast agent ultrasound contrast agent radioopaque medium contrast media radiocontrast agent radiocontrast agents radioopaque media radiopaque media radiopaque medium radioopaque medium EC 2.7.7.6 (RNA polymerase) inhibitor C RNA formation factors inhibitor C RNA formation factors inhibitors C ribonucleic acid formation factors inhibitor C ribonucleic acid formation factors inhibitors DNA-dependent RNA nucleotidyltransferase inhibitor DNA-dependent RNA nucleotidyltransferase inhibitors DNA-dependent RNA polymerase inhibitor DNA-dependent RNA polymerase inhibitors DNA-dependent ribonucleate nucleotidyltransferase inhibitor DNA-dependent ribonucleate nucleotidyltransferase inhibitors DNA-directed RNA polymerase inhibitor DNA-directed RNA polymerase inhibitors DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitor DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitors EC 2.7.7.6 (RNA polymerase) inhibitors EC 2.7.7.6 inhibitor EC 2.7.7.6 inhibitors RNA nucleotidyltransferase (DNA-directed) inhibitor RNA nucleotidyltransferase (DNA-directed) inhibitors RNA nucleotidyltransferase inhibitor RNA nucleotidyltransferase inhibitors RNA polymerase (EC 2.7.7.6) inhibitor RNA polymerase (EC 2.7.7.6) inhibitors RNA polymerase I inhibitor RNA polymerase I inhibitors RNA polymerase II inhibitor RNA polymerase II inhibitors RNA polymerase III inhibitor RNA polymerase III inhibitors RNA polymerase inhibitor RNA polymerase inhibitors RNA transcriptase inhibitor RNA transcriptase inhibitors deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitor deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitors directed RNA polymerase inhibitor nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitor nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitors ribonucleate nucleotidyltransferase inhibitor ribonucleate nucleotidyltransferase inhibitors ribonucleate polymerase inhibitor ribonucleate polymerase inhibitors ribonucleic acid nucleotidyltransferase inhibitor ribonucleic acid nucleotidyltransferase inhibitors ribonucleic acid polymerase inhibitor ribonucleic acid polymerase inhibitors ribonucleic acid transcriptase inhibitor ribonucleic acid transcriptase inhibitors ribonucleic polymerase inhibitor ribonucleic polymerase inhibitors ribonucleic transcriptase inhibitor ribonucleic transcriptase inhibitors transcriptase inhibitor transcriptase inhibitors EC 2.7.7.6 (RNA polymerase) inhibitor acid Acid Saeure Saeuren acid acide acido acids acid protease inhibitor protease inhibitors protease inhibitor protein kinase inhibitor protein kinase inhibitors protein kinase inhibitor EC 2.7.11.13 (protein kinase C) inhibitor ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitor ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitors EC 2.7.11.13 (protein kinase C) inhibitors EC 2.7.11.13 inhibitor EC 2.7.11.13 inhibitors PKC inhibitor PKC inhibitors PKCalpha inhibitor PKCalpha inhibitors PKCbeta inhibitor PKCbeta inhibitors PKCdelta inhibitor PKCdelta inhibitors PKCepsilon inhibitor PKCepsilon inhibitors PKCgamma inhibitor PKCgamma inhibitors PKCzeta inhibitor PKCzeta inhibitors PKN3 inhibitor PKN3 inhibitors Pkc1p inhibitor Pkc1p inhibitors STK24 inhibitor STK24 inhibitors cPKC inhibitor cPKC inhibitors cPKCalpha inhibitor cPKCalpha inhibitors cPKCbeta inhibitor cPKCbeta inhibitors cPKCgamma inhibitor cPKCgamma inhibitors calcium-dependent protein kinase C inhibitor calcium-dependent protein kinase C inhibitors calcium-independent protein kinase C inhibitor calcium-independent protein kinase C inhibitors calcium/phospholipid dependent protein kinase inhibitor calcium/phospholipid dependent protein kinase inhibitors nPKC inhibitor nPKC inhibitors nPKCdelta inhibitor nPKCdelta inhibitors nPKCepsilon inhibitor nPKCepsilon inhibitors nPKCeta inhibitor nPKCeta inhibitors nPKCtheta inhibitor nPKCtheta inhibitors protein kinase C (EC 2.7.11.13) inhibitor protein kinase C (EC 2.7.11.13) inhibitors protein kinase C inhibitor protein kinase C inhibitors protein kinase Cepsilon inhibitor protein kinase Cepsilon inhibitors EC 2.7.11.13 (protein kinase C) inhibitor EC 3.1.1.8 (cholinesterase) inhibitor BChE inhibitor BChE inhibitors BtChoEase inhibitor BtChoEase inhibitors EC 3.1.1.8 (cholinesterase) inhibitors EC 3.1.1.8 inhibitor EC 3.1.1.8 inhibitors anticholineesterase inhibitor anticholineesterase inhibitors anticholinesterase anticholinesterases benzoylcholinesterase inhibitor benzoylcholinesterase inhibitors butyrylcholine esterase inhibitor butyrylcholine esterase inhibitors butyrylcholinesterase inhibitor butyrylcholinesterase inhibitors choline esterase II (unspecific) inhibitor choline esterase II (unspecific) inhibitors choline esterase inhibitor choline esterase inhibitors cholinesterase (EC 3.1.1.8) inhibitor cholinesterase (EC 3.1.1.8) inhibitors cholinesterase inhibitor non-specific cholinesterase inhibitor non-specific cholinesterase inhibitors propionylcholinesterase inhibitor propionylcholinesterase inhibitors pseudocholinesterase inhibitor pseudocholinesterase inhibitors EC 3.1.1.8 (cholinesterase) inhibitor growth hormone GH Somatotropin Wachstumshormon growth hormones growth hormone plant hormone phytohormone phytohormones plant growth factor plant growth factors plant growth hormone plant growth hormones plant hormones plant hormone adrenergic agonist adrenergic agonists adrenergic receptor agonist adrenoceptor agonists adrenomimetic adrenomimetics adrenergic agonist adrenergic antagonist adrenergic antagonists adrenergic blockaders adrenergic blocker adrenergic blockers adrenergic receptor blockaders adrenoceptor antagonists adrenergic antagonist alpha-adrenergic antagonist alpha-adrenergic antagonists alpha-adrenergic blocker alpha-adrenergic blockers alpha-adrenergic receptor blockaders alpha-adrenoceptor antagonists alpha-adrenergic antagonist phenothiazine antipsychotic drug phenothiazine antipsychotic drugs phenothiazine antipsychotics phenothiazine neuroleptics phenothiazine antipsychotic drug H1-receptor antagonist H1 antihistaminics H1 receptor antagonists H1 receptor blockaders H1-receptor antagonists H1-receptor blocker H1-receptor blockers classical antihistamines classical antihistaminics H1-receptor antagonist histamine antagonist antihistamine antihistamines antihistaminico antihistaminics histamine receptor blocker histamine receptor blockers histamine antagonist histaminergic drug histamine agents histamine drugs histaminergic agent histaminergic agents histaminergic drugs histaminergic drug dye Farbstoff Farbstoffe colorante colorantes dyes teinture teintures dye H2-receptor antagonist H2 receptor antagonists H2 receptor blockaders H2-receptor blocker H2-receptor blockers histamine H2 receptor antagonist histamine H2 receptor antagonists H2-receptor antagonist adrenergic agent adrenergic agents adrenergic drug adrenergic drugs adrenergic neuron agents adrenergics adrenergic agent triazine insecticide triazine insecticide antimalarial antimalarials antimalarial anti-arrhythmia drug anti-arrhythmia agent antiarrhythmic agent anti-arrhythmia drug cardiotonic drug cardiotonic drugs cardiotonic drug phytosiderophore Phytosiderophor phytosiderophores phytosiderophore iron chelator iron chelating agents iron chelators iron chelator chelator Chelating agent Metal chelator chelating agents chelators complexon chelator iron(2+) chelator iron(2+) chelator calcium channel blocker calcium channel antagonist calcium channel antagonists calcium channel blockers calcium channel blocker phytotoxin phytotoxins phytotoxin DNA polymerase inhibitor DNA polymerase inhibitor EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) inhibitor 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) inhibitors 4-hydroxyphenylpyruvate dioxygenase inhibitor 4-hydroxyphenylpyruvate dioxygenase inhibitors 4-hydroxyphenylpyruvate hydroxylase inhibitor 4-hydroxyphenylpyruvate hydroxylase inhibitors 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitor 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitors 4-hydroxyphenylpyruvic acid dioxygenase inhibitor 4-hydroxyphenylpyruvic acid dioxygenase inhibitors EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitors EC 1.13.11.27 inhibitor EC 1.13.11.27 inhibitors HPPD inhibitor HPPD inhibitors p-hydroxyphenylpyruvate dioxygenase inhibitor p-hydroxyphenylpyruvate dioxygenase inhibitors p-hydroxyphenylpyruvate hydroxylase inhibitor p-hydroxyphenylpyruvate hydroxylase inhibitors p-hydroxyphenylpyruvate oxidase inhibitor p-hydroxyphenylpyruvate oxidase inhibitors p-hydroxyphenylpyruvic acid hydroxylase inhibitor p-hydroxyphenylpyruvic acid hydroxylase inhibitors p-hydroxyphenylpyruvic hydroxylase inhibitor p-hydroxyphenylpyruvic hydroxylase inhibitors p-hydroxyphenylpyruvic oxidase inhibitor p-hydroxyphenylpyruvic oxidase inhibitors EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor cholinergic drug cholinergic agent cholinergic drugs cholinomimetic cholinergic drug cholinergic agonist acetylcholine agonist acetylcholine agonists acetylcholine receptor agonist cholinergic agonists cholinomimetic cholinomimetics cholinergic agonist muscarinic agonist muscarinic acetylcholine receptor agonist muscarinic agonists muscarinic cholinergic agonist muscarinic cholinergic agonists muscarinic agonist ecdysone agonist ecdysone agonists ecdysone mimetic ecdysone agonist carbamate insecticide carbamate insecticides carbamate insecticide EC 3.1.1.7 (acetylcholinesterase) inhibitor AChEI AcCholE inhibitor AcCholE inhibitors EC 3.1.1.7 (acetylcholinesterase) inhibitors EC 3.1.1.7 inhibitor EC 3.1.1.7 inhibitors acetyl.beta-methylcholinesterase inhibitor acetyl.beta-methylcholinesterase inhibitors acetylcholine acetylhydrolase inhibitor acetylcholine acetylhydrolase inhibitors acetylcholine esterase inhibitor acetylcholine hydrolase inhibitor acetylcholine hydrolase inhibitors acetylcholinesterase (EC 3.1.1.7) inhibitor acetylcholinesterase (EC 3.1.1.7) inhibitors acetylcholinesterase inhibitor acetylcholinesterase inhibitors acetylthiocholinesterase inhibitor acetylthiocholinesterase inhibitors choline esterase I inhibitor choline esterase I inhibitors cholinesterase inhibitor cholinesterase inhibitors true cholinesterase inhibitor true cholinesterase inhibitors EC 3.1.1.7 (acetylcholinesterase) inhibitor electron-transport chain inhibitor electron-transport chain inhibitor respiratory-chain inhibitor respiratory-chain inhibitor mitochondrial NADH:ubiquinone reductase inhibitor mitochondrial NADH dehydrogenase inhibitor mitochondrial complex I inhibitor mitochondrial complex I inhibitors mitochondrial NADH:ubiquinone reductase inhibitor mitochondrial cytochrome-bc1 complex inhibitor mitochondrial complex III inhibitor mitochondrial complex III inhibitors mitochondrial cytochrome-bc1 complex inhibitor EC 1.9.3.1 (cytochrome c oxidase) inhibitor CcO inhibitor EC 1.9.3.1 (cytochrome c oxidase) inhibitors EC 1.9.3.1 inhibitor EC 1.9.3.1 inhibitors NADH cytochrome c oxidase inhibitor NADH cytochrome c oxidase inhibitors Warburg's respiratory enzyme inhibitor Warburg's respiratory enzyme inhibitors complex IV (mitochondrial electron transport) inhibitor complex IV (mitochondrial electron transport) inhibitors cytochrome a3 inhibitor cytochrome a3 inhibitors cytochrome aa3 inhibitor cytochrome aa3 inhibitors cytochrome c oxidase (EC 1.9.3.1) inhibitor cytochrome c oxidase (EC 1.9.3.1) inhibitors cytochrome c oxidase inhibitor cytochrome c oxidase inhibitors cytochrome oxidase inhibitor cytochrome oxidase inhibitors cytochrome-c oxidase inhibitor cytochrome-c oxidase inhibitors ferrocytochrome c oxidase inhibitor ferrocytochrome c oxidase inhibitors ferrocytochrome-c:oxygen oxidoreductase inhibitor ferrocytochrome-c:oxygen oxidoreductase inhibitors indophenol oxidase inhibitor indophenol oxidase inhibitors indophenolase inhibitor indophenolase inhibitors mitochondrial complex IV inhibitor mitochondrial complex IV inhibitors mitochondrial cytochrome-c oxidase inhibitors EC 1.9.3.1 (cytochrome c oxidase) inhibitor cytochrome-bc1 complex inhibitor cytochrome-bc1 complex inhibitor EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor DPNH-coenzyme Q reductase inhibitor DPNH-ubiquinone reductase inhibitor EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitor EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitors EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitors EC 1.6.5.3 inhibitor EC 1.6.5.3 inhibitors NADH coenzyme Q1 reductase inhibitor NADH coenzyme Q1 reductase inhibitors NADH dehydrogenase (ubiquinone) inhibitor NADH dehydrogenase (ubiquinone) inhibitors NADH-CoQ oxidoreductase inhibitor NADH-CoQ oxidoreductase inhibitors NADH-CoQ reductase inhibitor NADH-CoQ reductase inhibitors NADH-Q6 oxidoreductase inhibitor NADH-coenzyme Q oxidoreductase inhibitors NADH-coenzyme Q reductase inhibitor NADH-coenzyme Q reductase inhibitors NADH-ubiquinone oxidoreductase inhibitor NADH-ubiquinone oxidoreductase inhibitors NADH-ubiquinone reductase inhibitor NADH-ubiquinone reductase inhibitors NADH-ubiquinone-1 reductase inhibitor NADH-ubiquinone-1 reductase inhibitors NADH2 dehydrogenase (ubiquinone) inhibitor NADH:ubiquinone oxidoreductase complex inhibitor NADH:ubiquinone oxidoreductase inhibitor NADH:ubiquinone oxidoreductase inhibitors NADH:ubiquinone reductase (H(+)-translocating) inhibitor NADH:ubiquinone reductase (H(+)-translocating) inhibitors NADH:ubiquinone reductase (H+-translocating) inhibitor NADH:ubiquinone reductase inhibitor coenzyme Q reductase complex 1 dehydrogenase inhibitor complex I (NADH:Q1 oxidoreductase) inhibitors complex I (electron transport chain) inhibitors complex I (mitochondrial electron transport) inhibitors dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor electron transfer complex I inhibitor electron transfer complex I inhibitors mitochondrial electron transport complex 1 inhibitor mitochondrial electron transport complex I inhibitor mitochondrial electron transport complex I inhibitors reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitors type 1 dehydrogenase inhibitor type 1 dehydrogenase inhibitors ubiquinone reductase inhibitor ubiquinone reductase inhibitors EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor rosuvastatin (3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid (3R,5S,6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid rosuvastatin rosuvastatin EC 1.4.3.4 (monoamine oxidase) inhibitor EC 1.4.3.4 (monoamine oxidase) inhibitors EC 1.4.3.4 inhibitor EC 1.4.3.4 inhibitors MAO A inhibitor MAO A inhibitors MAO B inhibitor MAO B inhibitors MAO inhibitor MAO inhibitors MAO-A inhibitor MAO-A inhibitors MAO-B inhibitor MAO-B inhibitors adrenalin oxidase inhibitor adrenalin oxidase inhibitors adrenaline oxidase inhibitor adrenaline oxidase inhibitors amine oxidase (flavin-containing) inhibitor amine oxidase (flavin-containing) inhibitors amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitor amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitors amine:oxygen oxidoreductase (deaminating) inhibitor amine:oxygen oxidoreductase (deaminating) inhibitors epinephrine oxidase inhibitor epinephrine oxidase inhibitors monoamine oxidase (EC 1.4.3.4) inhibitor monoamine oxidase (EC 1.4.3.4) inhibitors monoamine oxidase A inhibitor monoamine oxidase A inhibitors monoamine oxidase B inhibitor monoamine oxidase B inhibitors monoamine oxidase inhibitor monoamine oxidase inhibitors monoamine:O2 oxidoreductase (deaminating) inhibitor monoamine:O2 oxidoreductase (deaminating) inhibitors serotonin deaminase inhibitor serotonin deaminase inhibitors tyraminase inhibitor tyraminase inhibitors tyramine oxidase inhibitor tyramine oxidase inhibitors EC 1.4.3.4 (monoamine oxidase) inhibitor membrane transport modulator membrane transport modulators membrane transport modulator sodium channel blocker Na channel blocker sodium channel blockers sodium channel blocker voltage-gated sodium channel blocker Nav channel blocker Nav channel blockers voltage-dependent sodium channel blockers voltage-gated sodium channel blocker tyrosine kinase inhibitor TKI inhibitor TKI inhibitors protein tyrosine kinase inhibitor protein tyrosine kinase inhibitors tyrosine kinase inhibitors tyrphostin tyrphostins tyrosine kinase inhibitor pediculicide pediculicides pediculicide calcium channel agonist calcium channel activator calcium channel activators calcium channel agonists calcium channel agonist calcium channel modulator calcium channel modulators calcium channel modulator ryanodine receptor modulator RyR modulator ryanodine receptor modulators ryanodine-sensitive calcium channel modulator ryanodine-sensitive calcium-release channel modulator ryanodine receptor modulator nonionic surfactant non-ionic surfactant nonionic surfactants nonionic surfactant blood substitute artificial blood blood substitutes oxygen carrier blood substitute anaesthetic Anaesthetika Anaesthetikum anaesthetic anaesthetics anesthetic agent anesthetic drug anesthetics anaesthetic general anaesthetic Allgemeinanaesthetika Allgemeinanaesthetikum general anaesthetic general anaesthetics general anesthetics general anaesthetic inhalation anaesthetic Inhalationsanaesthetika Inhalationsanaesthetikum Inhalationsnarkotika Inhalationsnarkotikum anesthetic gases inhalation anesthetics inhalation anaesthetic intravenous anaesthetic i.v.-Anaesthetika i.v.-Anaesthetikum intravenous anesthetics intravenous anaesthetic schistosomicide drug antischistosoma antischistosomal drug schistosomicide schistosomicide drugs schistosomicides schistosomicide drug ectoparasiticide ectoparasiticides ectoparasiticide GABA-gated chloride channel antagonist GABA-gated chloride channel antagonists GABA-gated chloride channel antagonist sodium channel modulator sodium channel modulators sodium channel modulator Good's buffer substance Good buffer substance Good's buffer Good's buffers Good's buffer substance pyrethroid ester insecticide pyrethroid ester insecticides pyrethroid ester insecticide Bronsted acid Bronsted acid Bronsted-Saeure acide de Bronsted donneur d'hydron hydron donor Bronsted acid Bronsted base Bronsted base Bronsted-Base accepteur d'hydron base de Bronsted hydron acceptor Bronsted base Lewis acid Lewis acid Lewis-Saeure accepteur d'une paire d'electrons acide de Lewis electron acceptor electron-pair acceptor Lewis acid Lewis base Lewis base Lewis-Base base de Lewis donneur d'une paire d'electrons electron donor Lewis base antibiotic insecticide antibiotic insecticide antibiotic pesticide antibiotic pesticide antibiotic acaricide antibiotic acaricide antibiotic nematicide antibiotic nematicide pyrethroid ester acaricide pyrethroid ester acaricide fumigant fumigant pesticide fumigants fumigant fumigant insecticide fumigant insecticides fumigant insecticide sulfite ester acaricide sulfite ester acaricide mite growth regulator mite growth regulator growth regulator growth regulators growth regulator tetrazine acaricide tetrazine acaricide pyrethroid ether insecticide pyrethroid ether insecticides pyrethroid ether insecticide pyrethroid ether acaricide pyrethroid ether acaricides pyrethroid ether acaricide homopteran inhibitor of chitin biosynthesis homopteran inhibitor of chitin biosynthesis lepidopteran inhibitor of chitin biosynthesis lepidopteran inhibitor of chitin biosynthesis bridged diphenyl acaricide bridged diphenyl acaricides bridged diphenyl acaricide dinitrophenol insecticide dinitrophenol insecticides dinitrophenol insecticide fluorescent probe fluorescent probe antiglaucoma drug anti-glaucoma agent anti-glaucoma agents anti-glaucoma drug anti-glaucoma drugs antiglaucoma agent antiglaucoma drugs antiglaucoma drug dextromethorphan (+)-3-methoxy-N-methylmorphinan (+)-dextromethorphan (4aS,10S,10aS)-6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene (9alpha,13alpha,14alpha)-3-methoxy-17-methylmorphinan 3-methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan Albutussin Antussan BA 2666 BA-2666 Balminil DM Benylin DM Calmylin D-methorphan DXM Delsym Dextromorphan Medicon Romilar Tusilan d-Methorphan destrometerfano dextromethorfan dextromethorphan dextromethorphane dextromethorphanum dextrometorfano dextromethorphan propofol 2,6-BIS(1-METHYLETHYL)PHENOL 2,6-Diisopropylphenol 2,6-bis(1-methylethyl)phenol 2,6-bis(propan-2-yl)phenol Diprivan Disoprivan Disoprofol Propofol Rapinovet propofol propofolum propofol troleandomycin (3R,5R,6S,7R,8R,11R,12S,13R,14S,15S)-12-[(4-O-acetyl-2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-{[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadecan-6-yl acetate Oleandocetine Oleandomycin triacetate Oleandomycin triacetyl ester Triacetyloleandomycin Triacetyloleandomycinum Tribiocillina Triocetin troleandomicina troleandomycin troleandomycine troleandomycinum troleandomycin trifluoperazine 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine Trifluoperazine trifluoperazina trifluoperazine trifluoperazinum trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine trifluoroperazine trifluperazine trifluoperazine solvent Loesungsmittel solvant solvents solvent diclofenac 2-((2,6-dichlorophenyl)amino)benzeneacetic acid 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid Diclofenac [2-(2,6-dichloroanilino)phenyl]acetic acid diclofenac diclofenac acid diclofenaco diclofenacum diclofenamic acid {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid diclofenac indicator Indikator indicator photosensitizing agent photosensitising agent photosensitizing agent nicotinic acetylcholine receptor agonist muscarinic agonists nicotinic acetylcholine receptor agonists nicotinic agonist nicotinic agonists nicotinic acetylcholine receptor agonist protein synthesis inhibitor protein synthesis antagonist protein synthesis antagonists protein synthesis inhibitors protein synthesis inhibitor antiseptic drug antiseptic antiseptic agent antiseptic agents antiseptics local antiinfective agents local microbicides topical antiinfective agents topical microbicides antiseptic drug disinfectant Desinfektionsmittel desinfectant disinfectants disinfecting agent disinfectant serotonergic drug serotonergic agents serotonergic drugs serotonin drugs serotonergic drug serotonergic antagonist 5-HT antagonists 5-hydroxytryptamine antagonists antiserotonergic agents serotonin antagonists serotonin blockaders serotonergic antagonist fragrance Parfuem aroma arome essence parfum perfume scent fragrance serine proteinase inhibitor serine proteinase inhibitors serine proteinase inhibitor polar solvent polar solvent polar solvents polar solvent non-polar solvent non-polar solvent protic solvent protogenic solvent protic solvent aprotic solvent aprotic solvent polar aprotic solvent dipolar aprotic solvent polar aprotic solvent protophilic solvent HBA solvent hydrogen bond acceptor solvent protophilic solvent protophilic solvent amphiprotic solvent amphiprotic solvent amphiprotic solvent EC 2.1.1.6 (catechol O-methyltransferase) inhibitor COMT inhibitor COMT inhibitors EC 2.1.1.6 (catechol O-methyltransferase) inhibitors EC 2.1.1.6 inhibitor EC 2.1.1.6 inhibitors S-adenosyl-L-methionine:catechol O-methyltransferase inhibitor S-adenosyl-L-methionine:catechol O-methyltransferase inhibitors catechol O-methyltransferase (EC 2.1.1.6) inhibitor catechol O-methyltransferase (EC 2.1.1.6) inhibitors catechol O-methyltransferase inhibitor catechol O-methyltransferase inhibitors catechol methyltransferase inhibitor catechol methyltransferase inhibitors catecholamine O-methyltransferase inhibitor catecholamine O-methyltransferase inhibitors EC 2.1.1.6 (catechol O-methyltransferase) inhibitor antiparkinson drug antiparkinson agent antiparkinson drug angiogenesis inhibitor angiogenesis antagonist angiostatic agents anti-angiogenic agent angiogenesis inhibitor topical anaesthetic topical anaesthetics topical anesthetic topical anaesthetic calcimimetic calcimimetics calcimimetic alpha-adrenergic drug alpha-adrenergic drugs alpha-adrenergic drug beta-adrenergic drug beta-adrenergic drugs beta-adrenergic drug EC 1.1.1.21 (aldehyde reductase) inhibitor ALR2 inhibitor ALR2 inhibitors EC 1.1.1.21 (aldehyde reductase) inhibitors EC 1.1.1.21 inhibitor EC 1.1.1.21 inhibitors NADPH-aldopentose reductase inhibitor NADPH-aldopentose reductase inhibitors NADPH-aldose reductase inhibitor NADPH-aldose reductase inhibitors aldehyde reductase (EC 1.1.1.21) inhibitor aldehyde reductase (EC 1.1.1.21) inhibitors aldehyde reductase inhibitor aldehyde reductase inhibitors alditol:NAD(P)(+) 1-oxidoreductase inhibitor alditol:NAD(P)(+) 1-oxidoreductase inhibitors alditol:NADP oxidoreductase inhibitor alditol:NADP oxidoreductase inhibitors alditol:NADP(+) 1-oxidoreductase inhibitor alditol:NADP(+) 1-oxidoreductase inhibitors aldose reductase inhibitor aldose reductase inhibitors polyol dehydrogenase (NADP(+)) inhibitor polyol dehydrogenase (NADP(+)) inhibitors EC 1.1.1.21 (aldehyde reductase) inhibitor dopaminergic agent dopamine agent dopamine agents dopamine drug dopamine drugs dopaminergic agents dopaminergic agent dopaminergic antagonist dopamine antagonist dopamine blocker dopamine receptor antagonist dopaminergic antagonists dopaminergic antagonist radical scavenger free radical scavengers free-radical scavenger radical scavenger gamma-secretase modulator Gamma-secretase modulator Gamma-secretase modulators gamma secretase modulator gamma secretase modulators gamma-secretase modulator gamma-secretase modulators gamma-secretase modulator antifibrinolytic drug antifibrinolytic agent antifibrinolytic agents antifibrinolytic drugs antifibrinolytic drug fibrin modulating drug fibrin modulating agent fibrin modulating agents fibrin modulating drugs fibrin modulating drug agonist agonist agonista agoniste agonists agonist antagonist antagonist antagonista antagoniste antagonists antagonist estropipate Estropipate Piperazine estrone sulfate estropipate cholinergic antagonist Anticholinergika Anticholinergikum acetylcholine antagonists acetylcholine receptor antagonist agent anticholinergique agente anticolinergico agentes anticolinergicos anticholinergic agents anticholinergics anticholinergiques anticolinergicos cholinergic-blocking agents cholinergic antagonist muscarinic antagonist Antimuskarinika Antimuskarinikum agente antimuscarinico agentes antimuscarinicos agents antimuscariniques antimuscarinic agents antimuscarinicos muscarinic acetylcholine receptor antagonist muscarinic antagonists muscarinic antagonist nicotinic antagonist agente antinicotinico agentes antinicotinicos agents antinicotiniques antinicotinicos nicotinic acetylcholine receptor antagonist nicotinic acetylcholine receptor antagonists nicotinic antagonists nicotinic cholinergic antagonist nicotinic cholinergic antagonists nicotinic antagonist bile acid metabolite bile acid metabolites bile salt metabolite bile acid metabolite hormone antagonist hormone antagonists hormone antagonist prostaglandin antagonist prostaglandin inhibitor prostaglandin antagonist drug metabolite drug metabolites drug metabolite peripheral nervous system drug peripheral nervous system agent peripheral nervous system drugs peripheral nervous system drug leukotriene antagonist LTRA leukotriene antagonists leukotriene receptor antagonist leukotriene receptor antagonists leukotriene antagonist anti-asthmatic drug anti-asthmatic agent anti-asthmatic agents anti-asthmatic drugs anti-asthmatic drug EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor (K(+) + H(+))-ATPase inhibitor (K(+) + H(+))-ATPase inhibitors ATP phosphohydrolase (H(+)/K(+)-exchanging) inhibitor ATP phosphohydrolase (H(+)/K(+)-exchanging) inhibitors EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitors EC 3.6.3.10 inhibitor EC 3.6.3.10 inhibitors H(+)-K(+)-ATPase inhibitor H(+)-K(+)-ATPase inhibitors H(+)/K(+)-ATPase inhibitor H(+)/K(+)-ATPase inhibitors H(+)/K(+)-exchanging ATPase inhibitor H(+)/K(+)-exchanging ATPase inhibitors H,K-ATPase inhibitor H,K-ATPase inhibitors proton pump inhibitor proton pump inhibitors EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor anti-ulcer drug anti-ulcer agent anti-ulcer agents anti-ulcer drugs anti-ulcer drug CETP inhibitor CETP inhibitors cholesteryl ester transfer protein inhibitor CETP inhibitor contraceptive drug contraceptive agent contraceptive drugs contraceptive drug female contraceptive drug female contraceptive agent female contraceptive drugs female contraceptive drug oral contraceptive oral contraceptives oral contraceptive synthetic oral contraceptive synthetic oral contraceptives synthetic oral contraceptive excitatory amino acid agonist excitatory amino acid agonists excitatory amino acid receptor agonist excitatory amino acid receptor agonists excitatory amino acid agonist sex hormone Geschlechtshormon Geschlechtshormone Sexualhormon Sexualhormone hormone sexuelle hormones sexuelles sex hormones sex hormone androgen Androgen Androgene androgene androgenes androgeno androgenos androgens androgen estrogen Estrogene Oestrogen Oestrogene estrogene estrogenes estrogenes Hormon estrogeno estrogenos estrogens oestrogen oestrogene oestrogenes oestrogens estrogen mu-opioid receptor antagonist mu-opioid antagonist mu-opioid antagonists mu-opioid receptor antagonists mu-opioid receptor antagonist bronchoconstrictor agent bronchoconstrictor agents bronchoconstrictor drug bronchoconstrictor agent keratolytic drug desquamating agent keratolytic agent keratolytic drugs skin-peeling agent keratolytic drug dermatologic drug dermatologic agent dermatologic drugs dermatological agent dermatologic drug P450 inhibitor CYP2D6 inhibitor CYP2D6 inhibitors P450 inhibitors cytochrome P450 inhibitor cytochrome P450 inhibitors P450 inhibitor ion transport inhibitor ion transport inhibitors ion-transport inhibitor ion-transport inhibitors ion transport inhibitor fatty acid synthesis inhibitor fatty acid synthesis inhibitors fatty acid synthesis inhibitor provitamin provitamins provitamin EC 3.1.4.* (phosphoric diester hydrolase) inhibitor EC 3.1.4.* (phosphoric diester hydrolase) inhibitors phosphodiesterase inhibitor phosphodiesterase inhibitors phosphoric diester hydrolase (EC 3.1.4.*) inhibitor phosphoric diester hydrolase (EC 3.1.4.*) inhibitors phosphoric diester hydrolase inhibitor phosphoric diester hydrolase inhibitors EC 3.1.4.* (phosphoric diester hydrolase) inhibitor cholinesterase reactivator cholinesterase reactivators cholinesterase reactivator enzyme reactivator enzyme reactivators enzyme reactivator antidote antidotes antidote hematologic agent hematologic agents hematologic agent anticoagulant anticoagulante anticoagulants anticoagulant prodrug Prodrugs prodrug protective agent chemoprotectant chemoprotectants chemoprotective agent chemoprotective agents protective agents protective agent GABA modulator GABA modulators GABA modulator EC 1.1.1.1 (alcohol dehydrogenase) inhibitor ADH inhibitor ADH inhibitors EC 1.1.1.1 (alcohol dehydrogenase) inhibitors EC 1.1.1.1 inhibitor EC 1.1.1.1 inhibitors NAD-dependent alcohol dehydrogenase inhibitor NAD-dependent alcohol dehydrogenase inhibitors NAD-specific aromatic alcohol dehydrogenase inhibitor NAD-specific aromatic alcohol dehydrogenase inhibitors NADH-alcohol dehydrogenase inhibitor NADH-alcohol dehydrogenase inhibitors NADH-aldehyde dehydrogenase inhibitor NADH-aldehyde dehydrogenase inhibitors alcohol dehydrogenase (EC 1.1.1.1) inhibitor alcohol dehydrogenase (EC 1.1.1.1) inhibitors alcohol dehydrogenase (NAD) inhibitor alcohol dehydrogenase (NAD) inhibitors alcohol dehydrogenase inhibitor alcohol dehydrogenase inhibitors alcohol:NAD+ oxidoreductase inhibitor alcohol:NAD+ oxidoreductase inhibitors aldehyde reductase inhibitor aldehyde reductase inhibitors aliphatic alcohol dehydrogenase inhibitor aliphatic alcohol dehydrogenase inhibitors ethanol dehydrogenase inhibitor ethanol dehydrogenase inhibitors primary alcohol dehydrogenase inhibitor primary alcohol dehydrogenase inhibitors yeast alcohol dehydrogenase inhibitor yeast alcohol dehydrogenase inhibitors EC 1.1.1.1 (alcohol dehydrogenase) inhibitor esomeprazole (-)-omeprazole (S)-(-)-omeprazole (S)-omeprazole 5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Alenia Escz Esofag Inexium paranova esomeprazol esomeprazole esomeprazolum esomeprazole EC 5.99.1.2 (DNA topoisomerase) inhibitor DNA topoisomerase inhibitor DNA topoisomerase inhibitors EC 5.99.1.2 (DNA topoisomerase) inhibitors EC 5.99.1.2 (topoisomerase I) inhibitor EC 5.99.1.2 (topoisomerase I) inhibitors EC 5.99.1.2 inhibitor EC 5.99.1.2 inhibitors topoisomerase I (EC 5.99.1.2) inhibitor topoisomerase I (EC 5.99.1.2) inhibitors topoisomerase I inhibitor topoisomerase I inhibitors type I DNA topoisomerase inhibitor type I DNA topoisomerase inhibitors EC 5.99.1.2 (DNA topoisomerase) inhibitor parasympatholytic parasympatholytics parasympatholytic EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor EC 2.4.1.80 (ceramide glucosyltransferase) inhibitors EC 2.4.1.80 inhibitor EC 2.4.1.80 inhibitors UDP-glucose:N-acylsphingosine D-glucosyltransferase inhibitor UDP-glucose:N-acylsphingosine D-glucosyltransferase inhibitors UDP-glucose:ceramide glucosyltransferase inhibitor UDP-glucose:ceramide glucosyltransferase inhibitors ceramide glucosyltransferase (EC 2.4.1.80) inhibitor ceramide glucosyltransferase (EC 2.4.1.80) inhibitors ceramide glucosyltransferase inhibitor ceramide glucosyltransferase inhibitors ceramide:UDP-glucose glucosyltransferase inhibitor ceramide:UDP-glucose glucosyltransferase inhibitors ceramide:UDPGlc glucosyltransferase inhibitor ceramide:UDPGlc glucosyltransferase inhibitors glucosylceramide synthase inhibitor glucosylceramide synthase inhibitors uridine diphosphoglucose-ceramide glucosyltransferase inhibitor uridine diphosphoglucose-ceramide glucosyltransferase inhibitors EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor DT diaphorase inhibitor EC 1.6.5.2 (NAD(P)H dehydrogenase (quinone)) inhibitor EC 1.6.5.2 (NAD(P)H dehydrogenase (quinone)) inhibitors EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitors EC 1.6.5.2 inhibitor EC 1.6.5.2 inhibitors NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) inhibitor NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) inhibitors NAD(P)H dehydrogenase (quinone) inhibitor NAD(P)H dehydrogenase (quinone) inhibitors NAD(P)H dehydrogenase inhibitor NAD(P)H dehydrogenase inhibitors NAD(P)H menadione reductase inhibitor NAD(P)H menadione reductase inhibitors NAD(P)H-quinone dehydrogenase inhibitor NAD(P)H-quinone dehydrogenase inhibitors NAD(P)H-quinone oxidoreductase inhibitor NAD(P)H-quinone oxidoreductase inhibitors NAD(P)H2 dehydrogenase (quinone) inhibitor NAD(P)H2 dehydrogenase (quinone) inhibitors NAD(P)H: menadione oxidoreductase inhibitor NAD(P)H: menadione oxidoreductase inhibitors NAD(P)H:(quinone-acceptor)oxidoreductase inhibitor NAD(P)H:(quinone-acceptor)oxidoreductase inhibitors NAD(P)H:quinone oxidoreductase inhibitor NAD(P)H:quinone oxidoreductase inhibitors NADH-menadione reductase inhibitor NADH-menadione reductase inhibitors NQO1 inhibitor NQO1 inhibitors QR1 inhibitor QR1 inhibitors dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) inhibitor dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) inhibitors diaphorase inhibitor diaphorase inhibitors flavoprotein NAD(P)H-quinone reductase inhibitor flavoprotein NAD(P)H-quinone reductase inhibitors menadione oxidoreductase inhibitor menadione oxidoreductase inhibitors menadione reductase inhibitor menadione reductase inhibitors naphthoquinone reductase inhibitor naphthoquinone reductase inhibitors p-benzoquinone reductase inhibitor p-benzoquinone reductase inhibitors phylloquinone reductase inhibitor phylloquinone reductase inhibitors quinone reductase inhibitor quinone reductase inhibitors reduced NAD(P)H dehydrogenase inhibitor reduced NAD(P)H dehydrogenase inhibitors reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase inhibitor reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase inhibitors viologen accepting pyridine nucleotide oxidoreductase inhibitor viologen accepting pyridine nucleotide oxidoreductase inhibitors vitamin K reductase inhibitor vitamin K reductase inhibitors vitamin-K reductase inhibitor vitamin-K reductase inhibitors EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor probe probe acid-base indicator Saeure-Base-Indikator Saeure-Base-Indikatoren acid-base indicator indicador acido-base indicateur acide-base acid-base indicator visual indicator indicador visual indicateur visuel visual indicator visual indicator adsorption indicator adsorption indicator indicador de adsorcion indicateur par adsorption adsorption indicator colour indicator colour indicator indicador de color indicateur colore indicateurs colores colour indicator one-colour indicator indicador monocolor indicador monocromico indicateur monocolore one-colour indicator one-colour indicator two-colour indicator indicador bicolor indicateur bicolore two-colour indicator two-colour indicator EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor EC 1.6.3.1 inhibitor EC 1.6.3.1 inhibitors EC 1.6.3.1. (NAD(P)H oxidase (H2O2-forming)) inhibitor EC 1.6.3.1. (NAD(P)H oxidase (H2O2-forming)) inhibitors EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitors NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) inhibitor NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) inhibitors NAD(P)H oxidase (H2O2-forming) inhibitor NAD(P)H oxidase (H2O2-forming) inhibitors NAD(P)H oxidase inhibitor NAD(P)H oxidase inhibitors NAD(P)H:oxygen oxidoreductase (H2O2-forming) inhibitor NAD(P)H:oxygen oxidoreductase (H2O2-forming) inhibitors NAD(P)H:oxygen oxidoreductase inhibitor NAD(P)H:oxygen oxidoreductase inhibitors NADPH oxidase inhibitor NADPH oxidase inhibitors THOX2 inhibitor THOX2 inhibitors ThOX inhibitor ThOX inhibitors dual oxidase inhibitor dual oxidase inhibitors p138tox inhibitor p138tox inhibitors thyroid NADPH oxidase inhibitor thyroid NADPH oxidase inhibitors thyroid oxidase 2 inhibitor thyroid oxidase 2 inhibitors thyroid oxidase inhibitor thyroid oxidase inhibitors EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor platelet aggregation inhibitor platelet aggregation inhibitors platelet aggregation inhibitor platelet glycoprotein-IIb/IIIa receptor antagonist GPIIb/IIIa antagonist GPIIb/IIIa antagonists fibrinogen receptor antagonist fibrinogen receptor antagonists glycoprotein-IIb/IIIa receptor antagonist glycoprotein-IIb/IIIa receptor antagonists platelet glycoprotein-IIb/IIIa receptor antagonists platelet glycoprotein-IIb/IIIa receptor antagonist adenosine phosphodiesterase inhibitor adenosine phosphodiesterase inhibitor EC 3.5.4.4 (adenosine deaminase) inhibitor ADA inhibitor EC 3.5.4.4 (adenosine deaminase) inhibitors EC 3.5.4.4 inhibitor EC 3.5.4.4 inhibitors adenosine aminohydrolase inhibitor adenosine aminohydrolase inhibitors adenosine deaminase (EC 3.5.4.4) inhibitor adenosine deaminase (EC 3.5.4.4) inhibitors adenosine deaminase inhibitor adenosine deaminase inhibitors deoxyadenosine deaminase inhibitor deoxyadenosine deaminase inhibitors EC 3.5.4.4 (adenosine deaminase) inhibitor EC 3.1.1.4 (phospholipase A2) inhibitor EC 3.1.1.4 (phospholipase A2) inhibitors EC 3.1.1.4 inhibitor EC 3.1.1.4 inhibitors lecithinase A inhibitor lecithinase A inhibitors phosphatidase inhibitor phosphatidase inhibitors phosphatidolipase inhibitor phosphatidolipase inhibitors phosphatidylcholine 2-acylhydrolase inhibitor phosphatidylcholine 2-acylhydrolase inhibitors phospholipase A inhibitor phospholipase A inhibitors phospholipase A2 (EC 3.1.1.4) inhibitor phospholipase A2 (EC 3.1.1.4) inhibitors phospholipase A2 inhibitor phospholipase A2 inhibitors EC 3.1.1.4 (phospholipase A2) inhibitor EC 2.5.1.15 (dihydropteroate synthase) inhibitor (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors 7,8-dihydropteroate synthase inhibitor 7,8-dihydropteroate synthase inhibitors 7,8-dihydropteroate synthetase inhibitor 7,8-dihydropteroate synthetase inhibitors 7,8-dihydropteroic acid synthetase inhibitor 7,8-dihydropteroic acid synthetase inhibitors DHPS inhibitor DHPS inhibitors EC 2.5.1.15 (dihydropteroate synthase) inhibitors EC 2.5.1.15 inhibitor EC 2.5.1.15 inhibitors dihydropteroate diphosphorylase inhibitor dihydropteroate diphosphorylase inhibitors dihydropteroate pyrophosphorylase inhibitor dihydropteroate pyrophosphorylase inhibitors dihydropteroate synthase (EC 2.5.1.15) inhibitor dihydropteroate synthase (EC 2.5.1.15) inhibitors dihydropteroate synthase inhibitor dihydropteroate synthase inhibitors dihydropteroate synthetase inhibitor dihydropteroate synthetase inhibitors dihydropteroic synthetase inhibitor dihydropteroic synthetase inhibitors EC 2.5.1.15 (dihydropteroate synthase) inhibitor laxative aperient aperients laxante laxatives purgative purgatives laxative osmotic diuretic osmotic diuretic sweetening agent sweetener sweeteners sweetening agent appetite depressant appetite depressant potassium channel blocker potassium channel blocker potassium channel modulator potassium channel modulator mydriatic agent mydriatics mydriatic agent vasoconstrictor agent vasoconstrictor agent protein denaturant protein denaturant nitric oxide donor NO donor NO donors NO generator NO generators NO releasing agent NO releasing agents nitric oxide donors nitric oxide generators nitric oxide releasing agent nitric oxide releasing agents nitric oxide donor EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor 3',5'-cyclic nucleoside monophosphate phosphodiesterase inhibitor 3',5'-cyclic nucleoside monophosphate phosphodiesterase inhibitors 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase inhibitor 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase inhibitors 3',5'-cyclic-nucleotide phosphodiesterase inhibitor 3',5'-cyclic-nucleotide phosphodiesterase inhibitors 3',5'-cyclonucleotide phosphodiesterase inhibitor 3',5'-cyclonucleotide phosphodiesterase inhibitors 3',5'-nucleotide phosphodiesterase inhibitor 3',5'-nucleotide phosphodiesterase inhibitors 3': 5'-monophosphate phosphodiesterase (cyclic CMP) inhibitor 3': 5'-monophosphate phosphodiesterase (cyclic CMP) inhibitors 3':5'-cyclic nucleotide 5'-nucleotidohydrolase inhibitor 3':5'-cyclic nucleotide 5'-nucleotidohydrolase inhibitors EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitors EC 3.1.4.17 inhibitor EC 3.1.4.17 inhibitors PDE inhibitor PDE inhibitors cyclic 3',5'-mononucleotide phosphodiesterase inhibitor cyclic 3',5'-mononucleotide phosphodiesterase inhibitors cyclic 3',5'-nucleotide phosphodiesterase inhibitor cyclic 3',5'-nucleotide phosphodiesterase inhibitors cyclic 3',5'-phosphodiesterase inhibitor cyclic 3',5'-phosphodiesterase inhibitors cyclic 3',5-nucleotide monophosphate phosphodiesterase inhibitor cyclic 3',5-nucleotide monophosphate phosphodiesterase inhibitors cyclic AMP phosphodiesterase inhibitor cyclic AMP phosphodiesterase inhibitors cyclic nucleotide phosphodiesterase inhibitor cyclic nucleotide phosphodiesterase inhibitors cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) inhibitor cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) inhibitors nucleoside 3',5'-cyclic phosphate diesterase inhibitor nucleoside 3',5'-cyclic phosphate diesterase inhibitors nucleoside-3',5-monophosphate phosphodiesterase inhibitor nucleoside-3',5-monophosphate phosphodiesterase inhibitors phosphodiesterase III inhibitor EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor EC 3.2.1.1 (alpha-amylase) inhibitor 1,4-alpha-D-glucan glucanohydrolase inhibitor 1,4-alpha-D-glucan glucanohydrolase inhibitors 4-alpha-D-glucan glucanohydrolase inhibitor 4-alpha-D-glucan glucanohydrolase inhibitors EC 3.2.1.1 (alpha-amylase) inhibitors EC 3.2.1.1 inhibitor EC 3.2.1.1 inhibitors Taka-amylase A inhibitor Taka-amylase A inhibitors alpha-amylase (EC 3.2.1.1) inhibitor alpha-amylase (EC 3.2.1.1) inhibitors alpha-amylase inhibitor alpha-amylase inhibitors endoamylase inhibitor endoamylase inhibitors glycogenase inhibitor glycogenase inhibitors EC 3.2.1.1 (alpha-amylase) inhibitor cyclooxygenase 2 inhibitor COX-2 inhibitor COX-2 inhibitors PGHS-2 inhibitor PGHS-2 inhibitors cyclo-oxygenase 2 inhibitor cyclo-oxygenase 2 inhibitors cyclo-oxygenase-2 inhibitor cyclo-oxygenase-2 inhibitors cyclooxygenase 2 inhibitors cyclooxygenase-2 inhibitor cyclooxygenase-2 inhibitors prostaglandin H synthase-2 inhibitor prostaglandin H synthase-2 inhibitors prostaglandin-endoperoxide synthase 2 inhibitor prostaglandin-endoperoxide synthase 2 inhibitors cyclooxygenase 2 inhibitor cyclooxygenase 1 inhibitor COX-1 inhibitor COX-1 inhibitors PTGS1 inhibitor PTGS1 inhibitors cyclo-oxygenase 1 inhibitor cyclo-oxygenase 1 inhibitors cyclooxygenase 1 inhibitors cyclooxygenase-1 inhibitor cyclooxygenase-1 inhibitors prostaglandin G/H synthase 1 inhibitor prostaglandin G/H synthase 1 inhibitors prostaglandin H2 synthase 1 inhibitor prostaglandin H2 synthase 1 inhibitors prostaglandin-endoperoxide synthase 1 inhibitor prostaglandin-endoperoxide synthase 1 inhibitors cyclooxygenase 1 inhibitor EC 3.5.1.5 (urease) inhibitor EC 3.5.1.5 (urease) inhibitors EC 3.5.1.5 inhibitor EC 3.5.1.5 inhibitors urea amidohydrolase inhibitor urea amidohydrolase inhibitors urease (EC 3.5.1.5) inhibitor urease (EC 3.5.1.5) inhibitors urease inhibitor urease inhibitors EC 3.5.1.5 (urease) inhibitor EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor (2E,6E)-farnesyl diphosphate synthetase inhibitor (2E,6E)-farnesyl diphosphate synthetase inhibitors DMAPP:IPP-dimethylallyltransferase inhibitor DMAPP:IPP-dimethylallyltransferase inhibitors EC 2.5.1.1 (dimethylallyltranstransferase) inhibitors EC 2.5.1.1 inhibitor EC 2.5.1.1 inhibitors dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase inhibitor dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase inhibitors dimethylallyltransferase inhibitor dimethylallyltransferase inhibitors dimethylallyltranstransferase (EC 2.5.1.1) inhibitor dimethylallyltranstransferase (EC 2.5.1.1) inhibitors dimethylallyltranstransferase inhibitor dimethylallyltranstransferase inhibitors diprenyltransferase inhibitor diprenyltransferase inhibitors geranyl pyrophosphate synthase inhibitor geranyl pyrophosphate synthase inhibitors geranyl pyrophosphate synthetase inhibitor geranyl pyrophosphate synthetase inhibitors geranyl-diphosphate synthase inhibitor geranyl-diphosphate synthase inhibitors prenyltransferase inhibitor prenyltransferase inhibitors trans-farnesyl pyrophosphate synthetase inhibitor trans-farnesyl pyrophosphate synthetase inhibitors EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor bone density conservation agent anti-osteopenia agent anti-osteopenia agents anti-osteopenia drug anti-osteopenia drugs anti-osteoporosis agent anti-osteoporosis agents anti-osteoporosis drug anti-osteoporosis drugs anti-osteoporotic anti-osteoporotic agent anti-osteoporotic agents anti-osteoporotic drug anti-osteoporotic drugs anti-osteoporotics antiosteoporotic antiosteoporotics bone density conservation agents bone density conservation drug bone density conservation drugs bone density conservation agent matrix metalloproteinase inhibitor MMPI matrix metalloproteinase inhibitors matrix metalloproteinase inhibitor antithyroid drug antithyroid agent antithyroid agents antithyroid drugs antithyroid drug EC 1.5.1.3 (dihydrofolate reductase) inhibitor 7,8-dihydrofolate reductase inhibitor 7,8-dihydrofolate reductase inhibitors DHFR inhibitor DHFR inhibitors EC 1.5.1.3 (dihydrofolate reductase) inhibitors EC 1.5.1.3 inhibitor EC 1.5.1.3 inhibitors NADPH-dihydrofolate reductase inhibitor NADPH-dihydrofolate reductase inhibitors dihydrofolate reductase (EC 1.5.1.3) inhibitor dihydrofolate reductase (EC 1.5.1.3) inhibitors dihydrofolate reductase inhibitor dihydrofolate reductase inhibitors dihydrofolic acid reductase inhibitor dihydrofolic acid reductase inhibitors dihydrofolic reductase inhibitor dihydrofolic reductase inhibitors folic acid reductase inhibitor folic acid reductase inhibitors folic reductase inhibitor folic reductase inhibitors tetrahydrofolate dehydrogenase inhibitor tetrahydrofolate dehydrogenase inhibitors EC 1.5.1.3 (dihydrofolate reductase) inhibitor cross-linking reagent cross-linking reagents cross-linking reagent antitrichomonal drug antitrichomonal agent antitrichomonal drug reproductive control drug reproductive control agent reproductive control drugs reproductive control drug abortifacient abortifacient agent abortifacient agents abortifacient drug abortifacient drugs abortifacients abortifacient EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitors EC 2.4.1.129 inhibitor EC 2.4.1.129 inhibitors PBP3 inhibitor PG-II inhibitor PG-II inhibitors [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitor [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitors bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitor bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitors penicillin binding protein 1B inhibitor penicillin binding protein 1B inhibitors penicillin binding protein 3 inhibitor penicillin binding protein 3 inhibitors peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitor peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitors peptidoglycan glycosyltransferase inhibitor peptidoglycan glycosyltransferase inhibitors peptidoglycan transglycosylase inhibitor peptidoglycan transglycosylase inhibitors undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitor undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitors EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor montelukast (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid 1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid MONTELUKAST Montelukast montelukast {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid montelukast nutraceutical Dietary Supplement Food Supplementation Nutritional supplement nutraceutical estrogen receptor modulator estrogen receptor modulator retinoic acid receptor alpha/beta agonist RAR alpha/beta agonist retinoic acid receptor alpha/beta agonist progestogen gestagen gestagens progestagen progestagens progestogens progestogen antipsoriatic antipsoriatic agent antipsoriatic drug antipsoriatic EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor DNA gyrase inhibitor DNA gyrase inhibitors DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors DNA topoisomerase (ATP-hydrolysing) inhibitor DNA topoisomerase (ATP-hydrolysing) inhibitors DNA topoisomerase II inhibitor DNA topoisomerase II inhibitors EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors EC 5.99.1.3 inhibitor EC 5.99.1.3 inhibitors inhibitor of type II topoisomerase inhibitors of type II topoisomerase topoisomerase II inhibitor topoisomerase II inhibitors topoisomerase-II inhibitor topoisomerase-II inhibitors type II DNA topoisomerase inhibitor type II DNA topoisomerase inhibitors EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor anti-estrogen anti-estrogenic agent anti-estrogenic drug anti-oestrogen anti-oestrogenic agent anti-oestrogenic drug antiestrogen antiestrogenic agent antiestrogenic drug antioestrogen antioestrogenic agent antioestrogenic drug anti-estrogen appetite enhancer appetite enhancing drug appetite stimulant orexigenic appetite enhancer appetite regulator appetite regulators appetite regulator EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) (EC 1.3.1.22) inhibitor 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) (EC 1.3.1.22) inhibitors 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) inhibitor 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) inhibitors 3-oxo-5alpha-steroid 4-dehydrogenase inhibitor 3-oxo-5alpha-steroid 4-dehydrogenase inhibitors 3-oxo-5alpha-steroid:NADP+ Delta(4)-oxidoreductase inhibitor 3-oxo-5alpha-steroid:NADP+ Delta(4)-oxidoreductase inhibitors 3-oxosteroid 5alpha-reductase inhibitor 3-oxosteroid Delta4-dehydrogenase inhibitor 4-ene-3-oxosteroid 5alpha-reductase inhibitor 4-ene-5alpha-reductase inhibitor 5alpha-oxidoreductase inhibitor 5alpha-oxidoreductase inhibitors 5alpha-reductase inhibitor 5alpha-reductase inhibitors Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitor Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitors EC 1.3.1.22 (3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))) inhibitor EC 1.3.1.22 (3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))) inhibitors EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitors EC 1.3.1.22 inhibitor EC 1.3.1.22 inhibitors cholest-4-en-3-one 5alpha-reductase inhibitor cholestenone 5alpha-reductase inhibitor cholestenone 5alpha-reductase inhibitors reduced nicotinamide adenine dinucleotide phosphate:Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitor reduced nicotinamide adenine dinucleotide phosphate:Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitors steroid 5alpha-hydrogenase inhibitor steroid 5alpha-hydrogenase inhibitors steroid 5alpha-reductase inhibitor steroid 5alpha-reductase inhibitors testosterone 5alpha-reductase inhibitor testosterone 5alpha-reductase inhibitors testosterone Delta(4)-5alpha-reductase inhibitor testosterone Delta(4)-5alpha-reductase inhibitors testosterone Delta(4)-hydrogenase inhibitor testosterone Delta(4)-hydrogenase inhibitors EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor 3beta (or 20alpha)-hydroxysteroid dehydrogenase inhibitor 3beta (or 20alpha)-hydroxysteroid dehydrogenase inhibitors 3beta(or 20alpha)-hydroxysteroid dehydrogenase (EC 1.1.1.210) inhibitor 3beta(or 20alpha)-hydroxysteroid dehydrogenase (EC 1.1.1.210) inhibitors 3beta(or 20alpha)-hydroxysteroid dehydrogenase inhibitor 3beta(or 20alpha)-hydroxysteroid dehydrogenase inhibitors 3beta(or 20alpha)-hydroxysteroid:NADP(+) oxidoreductase inhibitor 3beta(or 20alpha)-hydroxysteroid:NADP(+) oxidoreductase inhibitors 3beta,20alpha-hydroxysteroid oxidoreductase inhibitor 3beta,20alpha-hydroxysteroid oxidoreductase inhibitors 3beta-HSD 3beta-hydroxysteroid dehydrogenase 3beta-hydroxysteroid dehydrogenase inhibitor EC 1.1.1.210 (3beta(or 20alpha)-hydroxysteroid dehydrogenase) inhibitor EC 1.1.1.210 (3beta(or 20alpha)-hydroxysteroid dehydrogenase) inhibitors EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitors EC 1.1.1.210 inhibitor EC 1.1.1.210 inhibitors dehydrogenase, 3beta,20alpha-hydroxy steroid inhibitor dehydrogenase, 3beta,20alpha-hydroxy steroid inhibitors progesterone reductase inhibitor progesterone reductase inhibitors EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor EC 1.14.14.14 (aromatase) inhibitor EC 1.14.14.14 (aromatase) inhibitors EC 1.14.14.14 inhibitor EC 1.14.14.14 inhibitors aromatase (EC 1.14.14.14) inhibitor aromatase (EC 1.14.14.14) inhibitors aromatase inhibitor aromatase inhibitors estrogen synthase inhibitor estrogen synthase inhibitors estrogen synthetase inhibitor estrogen synthetase inhibitors oestrogen synthase inhibitor oestrogen synthase inhibitors oestrogen synthetase inhibitor oestrogen synthetase inhibitors EC 1.14.14.14 (aromatase) inhibitor estrogen receptor antagonist estrogen receptor antagonists estrogen receptor antagonist antiparathyroid drug antiparathyroid agent antiparathyroid agents antiparathyroid drugs antiparathyroid drug estrogen antagonist oestrogen antagonist estrogen antagonist antimineralocorticoid antimineralocorticoid aldosterone antagonist aldosterone antagonist immunomodulator Biomodulator Immune factor Immunologic factor Immunological factor immunomodulators immunomodulator immunological adjuvant Immunoactivator Immunoadjuvant Immunologic adjuvant Immunopotentiator Immunostimulant immunological adjuvant antiatherogenic agent anti-atherogenic agent anti-atherogenic agents anti-atherogenic drug anti-atherogenic drugs antiatherogenic agent antiatherogenic agents antiatherogenic drug antiatherogenic drugs antiatherogenic agent anti-allergic agent anti-allergic agents anti-allergic drug anti-allergic drugs anti-allergic agent insulin-sensitizing drug PPAR-gamma agonist PPAR-gamma agonists PPARgamma agonist PPARgamma agonists glitazonas glitazone drug glitazones insulin sensitisers insulin sensitizers insulin-sensitising drug insulin-sensitizing agent peroxisome proliferator-activated receptor gamma agonist peroxisome proliferator-activated receptor gamma agonists proliferator activated receptor gamma agonist proliferator activated receptor gamma agonists thiazolidinediones tiazolidinedionas insulin-sensitizing drug genotoxin genotoxic agent genotoxic agents genotoxins genotoxin carcinogenic agent agente carcinogeno cancerigene cancerogene carcinogen carcinogene carcinogenic agents carcinogeno carcinogens carcinogenic agent allergen alergeno allergene allergenic agent allergen teratogenic agent agent teratogene teratogen teratogeno teratogenic agent deaminating agent deaminating agent hepatotoxic agent agente hepatotoxico hepatotoxic agents hepatotoxicant hepatotoxicants hepatotoxin hepatotoxins hepatoxic agent hepatoxicant hepatotoxic agent nephrotoxic agent agente nefrotoxico nephrotoxicant nephrotoxic agent neurotoxin agente neurotoxico nerve poison nerve poisons neurotoxic agent neurotoxic agents neurotoxicant neurotoxins neurotoxin cardiotoxic agent cardiotoxicant cardiotoxic agent fixative fixating agent fixating agents fixation agent fixative EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor 1-phosphatidylinositol 3-kinase inhibitor 1-phosphatidylinositol 3-kinase inhibitors ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase inhibitor ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase inhibitors EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitors EC 2.7.1.137 inhibitor EC 2.7.1.137 inhibitors PI(3)K inhibitor PI(3)K inhibitors PI-3 kinase inhibitor PI-3 kinase inhibitors PI3-kinase inhibitor PI3-kinase inhibitors PI3K inhibitor PI3K inhibitors PtdIns-3-kinase inhibitor PtdIns-3-kinase inhibitors Vps34p inhibitor Vps34p inhibitors phosphatidylinositol 3-kinase (EC 2.7.1.137) inhibitor phosphatidylinositol 3-kinase (EC 2.7.1.137) inhibitors phosphatidylinositol 3-kinase inhibitor phosphatidylinositol 3-kinase inhibitors phosphatidylinositol-3-OH kinase inhibitor phosphatidylinositol-3-OH kinase inhibitors phosphoinositide 3-kinase inhibitor phosphoinositide 3-kinase inhibitors type I phosphatidylinositol kinase inhibitor type I phosphatidylinositol kinase inhibitors type III phosphoinositide 3-kinase inhibitor type III phosphoinositide 3-kinase inhibitors EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor lipid kinase inhibitor lipid kinase inhibitors lipid kinase inhibitor antiemetic anti-emetic anti-emetics antiemetico antiemetics antiemetic EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor A-kinase inhibitor A-kinase inhibitors AP50 kinase inhibitor AP50 kinase inhibitors ATP-protein transphosphorylase inhibitor ATP-protein transphosphorylase inhibitors ATP:protein phosphotransferase (non-specific) inhibitor ATP:protein phosphotransferase (non-specific) inhibitors BR serine/threonine-protein kinase 2 inhibitor BR serine/threonine-protein kinase 2 inhibitors CK-2 inhibitor CK-2 inhibitors CKI inhibitor CKI inhibitors CKII inhibitor CKII inhibitors EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors EC 2.7.11.1 inhibitor EC 2.7.11.1 inhibitors HIPK2 inhibitor HIPK2 inhibitors Hpr kinase inhibitor Hpr kinase inhibitors M phase-specific cdc2 kinase inhibitor M phase-specific cdc2 kinase inhibitors MKNK2 inhibitor MKNK2 inhibitors PAK-1 inhibitor PAK-1 inhibitors PAK1 inhibitor PAK1 inhibitors PKA inhibitor PKA inhibitors Prp4 protein kinase inhibitor Prp4 protein kinase inhibitors Raf kinase inhibitor Raf kinase inhibitors Raf-1 inhibitor Raf-1 inhibitors STK32 inhibitor STK32 inhibitors T-antigen kinase inhibitor T-antigen kinase inhibitors WEE1Hu inhibitor WEE1Hu inhibitors Wee 1-like kinase inhibitor Wee 1-like kinase inhibitors Wee-kinase inhibitor Wee-kinase inhibitors betaIIPKC inhibitor betaIIPKC inhibitors cAMP-dependent protein kinase A inhibitor cAMP-dependent protein kinase A inhibitors cAMP-dependent protein kinase inhibitor cAMP-dependent protein kinase inhibitors cGMP-dependent protein kinase inhibitor cGMP-dependent protein kinase inhibitors calcium-dependent protein kinase C inhibitor calcium-dependent protein kinase C inhibitors calcium/phospholipid-dependent protein kinase inhibitor calcium/phospholipid-dependent protein kinase inhibitors casein kinase (phosphorylating) inhibitor casein kinase (phosphorylating) inhibitors casein kinase 2 inhibitor casein kinase 2 inhibitors casein kinase I inhibitor casein kinase I inhibitors casein kinase II inhibitor casein kinase II inhibitors casein kinase inhibitor casein kinase inhibitors cyclic AMP-dependent protein kinase A inhibitor cyclic AMP-dependent protein kinase A inhibitors cyclic AMP-dependent protein kinase inhibitor cyclic AMP-dependent protein kinase inhibitors cyclic monophosphate-dependent protein kinase inhibitor cyclic monophosphate-dependent protein kinase inhibitors cyclic nucleotide-dependent protein kinase inhibitor cyclic nucleotide-dependent protein kinase inhibitors cyclin-dependent kinase inhibitor cyclin-dependent kinase inhibitors dsk1 inhibitor dsk1 inhibitors epsilon PKC inhibitor epsilon PKC inhibitors glycogen synthase a kinase inhibitor glycogen synthase a kinase inhibitors glycogen synthase kinase inhibitor glycogen synthase kinase inhibitors hydroxyalkyl-protein kinase inhibitor hydroxyalkyl-protein kinase inhibitors mitogen-activated S6 kinase inhibitor mitogen-activated S6 kinase inhibitors non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitor non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors non-specific serine/threonine protein kinase inhibitor non-specific serine/threonine protein kinase inhibitors p21 activated kinase-1 inhibitor p21 activated kinase-1 inhibitors p82 kinase inhibitor p82 kinase inhibitors phosphorylase b kinase kinase inhibitor phosphorylase b kinase kinase inhibitors protein glutamyl kinase inhibitor protein glutamyl kinase inhibitors protein kinase (phosphorylating) inhibitor protein kinase (phosphorylating) inhibitors protein kinase A inhibitor protein kinase A inhibitors protein kinase CK2 inhibitor protein kinase CK2 inhibitors protein kinase p58 inhibitor protein kinase p58 inhibitors protein phosphokinase inhibitor protein phosphokinase inhibitors protein serine kinase inhibitor protein serine kinase inhibitors protein serine-threonine kinase inhibitor protein serine-threonine kinase inhibitors protein-aspartyl kinase inhibitor protein-aspartyl kinase inhibitors protein-cysteine kinase inhibitor protein-cysteine kinase inhibitors protein-serine kinase inhibitor protein-serine kinase inhibitors protein-serine/threonine kinase inhibitors ribosomal S6 protein kinase inhibitor ribosomal S6 protein kinase inhibitors ribosomal protein S6 kinase II inhibitor ribosomal protein S6 kinase II inhibitors serine kinase inhibitor serine kinase inhibitors serine protein kinase inhibitor serine protein kinase inhibitors serine(threonine) protein kinase inhibitor serine(threonine) protein kinase inhibitors serine-specific protein kinase inhibitor serine-specific protein kinase inhibitors serine/threonine protein kinase inhibitor serine/threonine protein kinase inhibitors threonine-specific protein kinase inhibitor threonine-specific protein kinase inhibitors twitchin kinase inhibitor twitchin kinase inhibitors type-2 casein kinase inhibitor type-2 casein kinase inhibitors EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor angiogenesis modulating agent angiogenesis modulating agent serotonin uptake inhibitor SSRI serotonin reuptake inhibitor serotonin uptake inhibitor dopamine uptake inhibitor DARI DRI dopamine reuptake inhibitor dopamine reuptake inhibitors dopamine uptake inhibitors dopamine uptake inhibitor hormone agonist hormone agonist hormone receptor modulator hormone receptor modulators hormone receptor modulator dopamine agonist Agonista dopaminergico Dopamine receptor agonist Dopaminergic agonist dopamine agonist miotic Miotico miotics miotic antifouling biocide Antifoulant Antifouling agent Marine pesticide antifouling biocide chemical role chemical role protecting group Schutzgruppe Schutzgruppen groupe protecteur protective group protecting group fluorescent dye fluorescent dyes fluorescent dye Wittig reagent Wittig reagents reactif de Wittig reactivo de Wittig reactivos de Wittig Wittig reagent antitussive anti-tussive cough suppressant cough suppressants antitussive fluorochrome fluorochromes fluorochrome Grignard reagent Grignards Reagens Grignard reagent gelator gelator swelling agent swelling agent drying control chemical additive drying control chemical additive muscle relaxant muscle relaxants muscle relaxant neuromuscular agent neuromuscular agent GABA agonist GABA agonists GABA receptor agonist GABA receptor agonists gamma-aminobutyric acid receptor agonist gamma-aminobutyric acid receptor agonists GABA agonist GABA agent GABA agent endothelin receptor antagonist ERA endothelin receptor antagonist endothelin A receptor antagonist endothelin A receptor antagonist partial prostacyclin agonist partial prostacyclin agonist biochemical role biochemical role biophysical role biophysical role aetiopathogenetic role etiopathogenetic agent etiopathogenetic role aetiopathogenetic role pharmacological role pharmacological role physiological role physiological role ligand ligands ligand photochemical role photochemical roles photochemical role photobiochemical role photobiochemical role pharmaceutical farmaco medicament pharmaceuticals pharmaceutical squaraine dye squaraine dye mitogen mitogens mitogen sterol methyltransferase inhibitor sterol methyltransferase inhibitor EC 3.2.1.* (glycosidase) inhibitor EC 3.2.1.* (glycosidase) inhibitors EC 3.2.1.* inhibitor EC 3.2.1.* inhibitors glycosidase (EC 3.2.1.*) inhibitor glycosidase (EC 3.2.1.*) inhibitors glycosidase inhibitor glycosidase inhibitors glycoside hydrolase inhibitors EC 3.2.1.* (glycosidase) inhibitor EC 3.2.1.18 (exo-alpha-sialidase) inhibitor EC 3.2.1.18 (exo-alpha-sialidase) inhibitors EC 3.2.1.18 inhibitor EC 3.2.1.18 inhibitors N-acylneuraminate glycohydrolase inhibitor N-acylneuraminate glycohydrolase inhibitors acetylneuraminidase inhibitor acetylneuraminidase inhibitors acetylneuraminyl hydrolase inhibitor acetylneuraminyl hydrolase inhibitors alpha-neuraminidase inhibitor alpha-neuraminidase inhibitors exo-alpha-sialidase (EC 3.2.1.18) inhibitor exo-alpha-sialidase (EC 3.2.1.18) inhibitors exo-alpha-sialidase inhibitor exo-alpha-sialidase inhibitors neuraminidase inhibitor neuraminidase inhibitors sialidase inhibitor sialidase inhibitors EC 3.2.1.18 (exo-alpha-sialidase) inhibitor EC 3.1.26.13 (retroviral ribonuclease H) inhibitor EC 3.1.26.13 (retroviral ribonuclease H) inhibitors EC 3.1.26.13 inhibitor EC 3.1.26.13 inhibitors HIV RNase H inhibitor HIV RNase H inhibitors HIV-1 RNase H inhibitor HIV-1 RNase H inhibitors HIV-1 ribonuclease H inhibitor HIV-1 ribonuclease H inhibitors RT/RNase H inhibitor RT/RNase H inhibitors retroviral reverse transcriptase RNaseH inhibitor retroviral reverse transcriptase RNaseH inhibitors retroviral ribonuclease H (EC 3.1.26.13) inhibitor retroviral ribonuclease H (EC 3.1.26.13) inhibitors retroviral ribonuclease H inhibitor EC 3.1.26.13 (retroviral ribonuclease H) inhibitor proteasome inhibitor proteasome inhibitors proteasome inhibitor phosphate protecting group phosphate protecting groups phosphate protecting group carboxylic acid protecting group carboxylic acid protecting groups carboxylic acid protecting group epitope antigenic determinant epitope function epitope role epitope adenosine A2A receptor antagonist adenosine A2A receptor antagonists adenosine A2A receptor antagonist P2Y2 receptor agonist P2Y2 receptor agonists P2Y2 receptor agonist tissue adhesive tissue adhesives tissue adhesive GHB receptor agonist GHB receptor agonists GHB receptor agonist chain carrier chain carriers chain carrier topoisomerase IV inhibitor topoisomerase IV inhibitors topoisomerase IV inhibitor EC 1.4.3.22 (diamine oxidase) inhibitor EC 1.4.3.22 (diamine oxidase) inhibitors EC 1.4.3.22 inhibitor EC 1.4.3.22 inhibitors diamine oxidase (EC 1.4.3.22) inhibitor diamine oxidase (EC 1.4.3.22) inhibitors diamine oxidase inhibitor diamine oxidase inhibitors histaminase inhibitor histaminase inhibitors histamine:oxygen oxidoreductase (deaminating) inhibitor histamine:oxygen oxidoreductase (deaminating) inhibitors EC 1.4.3.22 (diamine oxidase) inhibitor EC 1.1.1.205 (IMP dehydrogenase) inhibitor EC 1.1.1.205 (IMP dehydrogenase) inhibitors EC 1.1.1.205 inhibitor EC 1.1.1.205 inhibitors IMP dehydrogenase (EC 1.1.1.205) inhibitor IMP dehydrogenase (EC 1.1.1.205) inhibitors IMP dehydrogenase inhibitor IMP dehydrogenase inhibitors IMP oxidoreductase inhibitor IMP oxidoreductase inhibitors IMP:NAD(+) oxidoreductase inhibitor IMP:NAD(+) oxidoreductase inhibitors inosinate dehydrogenase inhibitor inosinate dehydrogenase inhibitors inosine 5'-monophosphate dehydrogenase inhibitors inosine monophosphate dehydrogenase inhibitor inosine monophosphate dehydrogenase inhibitors inosine monophosphate oxidoreductase inhibitor inosine monophosphate oxidoreductase inhibitors inosinic acid dehydrogenase inhibitor inosinic acid dehydrogenase inhibitors EC 1.1.1.205 (IMP dehydrogenase) inhibitor HIV-1 reverse transcriptase inhibitor HIV-1 reverse transcriptase inhibitors reverse transcriptase inhibitor reverse transcriptase inhibitors HIV-1 reverse transcriptase inhibitor antispasmodic drug antispasmodics antispasmodic drug mu-opioid receptor agonist mu opioid agonist mu-opioid agonists mu-opioid receptor agonists mu-opioid receptor agonist antidiarrhoeal drug antidiarrheal antidiarrheal agent antidiarrheal agents antidiarrheal drug antidiarrheal drugs antidiarrheals antidiarrhoeal antidiarrhoeal agent antidiarrhoeal agents antidiarrhoeal drugs antidiarrhoeals antiperistaltic antiperistaltic agent antiperistaltic agents antiperistaltic drug antiperistaltic drugs antiperistaltics antidiarrhoeal drug gastrointestinal drug gastrointestinal agent gastrointestinal agents gastrointestinal drugs gastrointestinal drug vitamin K antagonist vitamin K antagonists vitamin K antagonist neurokinin-1 receptor antagonist NK-1 receptor antagonist NK-1 receptor antagonists NK1 receptor antagonist NK1 receptor antagonists neurokinin-1 receptor antagonists neurokinin-1 receptor antagonist substance P receptor antagonist substance P receptor antagonists substance P receptor antagonist antiseborrheic antiseborrheic agent antiseborrheic agents antiseborrheic drug antiseborrheics antiseborrheic EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor EC 6.3.2.* (acid--D-amino-acid ligase (peptide synthase)) inhibitor EC 6.3.2.* (acid--D-amino-acid ligase (peptide synthase)) inhibitors EC 6.3.2.* (acid--D-amino-acid ligase) inhibitors EC 6.3.2.* (acid--amino-acid ligase) inhibitor EC 6.3.2.* (acid--amino-acid ligase) inhibitors EC 6.3.2.* [acid--D-amino-acid ligase (peptide synthase)] inhibitor EC 6.3.2.* [acid--D-amino-acid ligase (peptide synthase)] inhibitors EC 6.3.2.* inhibitor EC 6.3.2.* inhibitors acid--amino-acid ligase inhibitor acid--amino-acid ligase inhibitors peptide synthase inhibitor peptide synthase inhibitors EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor EC 3.4.24.* (metalloendopeptidase) inhibitor EC 3.4.24.* (metalloendopeptidase) inhibitors EC 3.4.24.* inhibitor EC 3.4.24.* inhibitors inhibitor of metalloendopeptidases inhibitor of metalloendopeptidases (EC 3.4.24.*) inhibitors of metalloendopeptidases inhibitors of metalloendopeptidases (EC 3.4.24.*) metalloendopeptidase (EC 3.4.24.*) inhibitor metalloendopeptidase (EC 3.4.24.*) inhibitors metalloendopeptidase inhibitors EC 3.4.24.* (metalloendopeptidase) inhibitor antigen antigens antigen biomarker biological marker biomarker hapten haptens hapten GnRH antagonist GnRH antagonists gonadotrophin-releasing hormone antagonist gonadotrophin-releasing hormone antagonists GnRH antagonist EC 3.4.21.* (serine endopeptidase) inhibitor EC 3.4.21.* (serine endopeptidase) inhibitors EC 3.4.21.* inhibitor EC 3.4.21.* inhibitors inhibitor of serine endopeptidase (EC 3.4.21.*) inhibitor of serine endopeptidase (EC 3.4.21.*)s serine endopeptidase inhibitor serine endopeptidase inhibitors EC 3.4.21.* (serine endopeptidase) inhibitor kappa-opioid receptor agonist kappa-opioid agonist kappa-opioid receptor agonists kappa-opioid receptor agonist delta-opioid receptor antagonist delta-opioid antagonist delta-opioid antagonists delta-opioid receptor antagonist EC 1.14.13.132 (squalene monooxygenase) inhibitor EC 1.14.13.132 (squalene monooxygenase) inhibitors squalene 2,3-oxidocyclase inhibitor squalene 2,3-oxidocyclase inhibitors squalene epoxidase inhibitor squalene epoxidase inhibitors squalene hydroxylase inhibitor squalene hydroxylase inhibitors squalene monooxygenase (EC 1.14.13.132) inhibitor squalene monooxygenase (EC 1.14.13.132) inhibitors squalene monooxygenase inhibitor squalene monooxygenase inhibitors squalene oxydocyclase inhibitor squalene oxydocyclase inhibitors squalene-2,3-epoxidase inhibitor squalene-2,3-epoxidase inhibitors squalene-2,3-epoxide cyclase inhibitor squalene-2,3-epoxide cyclase inhibitors EC 1.14.13.132 (squalene monooxygenase) inhibitor EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor 5-hydroxytryptophan decarboxylase inhibitor 5-hydroxytryptophan decarboxylase inhibitors DOPA decarboxylase inhibitor DOPA decarboxylase inhibitors EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitors EC 4.1.1.28 inhibitor EC 4.1.1.28 inhibitors L-DOPA decarboxylase inhibitor L-DOPA decarboxylase inhibitors aromatic amino acid decarboxylase inhibitor aromatic amino acid decarboxylase inhibitors aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) inhibitor aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) inhibitors aromatic-L-amino-acid decarboxylase inhibitor aromatic-L-amino-acid decarboxylase inhibitors hydroxytryptophan decarboxylase inhibitor hydroxytryptophan decarboxylase inhibitors tryptophan decarboxylase inhibitor tryptophan decarboxylase inhibitors EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor EC 3.4.13.* (dipeptidase) inhibitor EC 3.4.13.* (dipeptidase) inhibitors EC 3.4.13.* inhibitor EC 3.4.13.* inhibitors dipeptidase inhibitor dipeptidase inhibitors EC 3.4.13.* (dipeptidase) inhibitor DNA synthesis inhibitor DNA synthesis inhibitors DNA synthesis inhibitor phosphoantigen phosphoantigens phosphoantigen EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor 3-oxosphinganine synthetase inhibitor 3-oxosphinganine synthetase inhibitors EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitors EC 2.3.1.50 inhibitor EC 2.3.1.50 inhibitors SPT inhibitor SPT inhibitors acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitor acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitors palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitor palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitors serine C-palmitoyltransferase (EC 2.3.1.50) inhibitor serine C-palmitoyltransferase (EC 2.3.1.50) inhibitors serine C-palmitoyltransferase inhibitor serine C-palmitoyltransferase inhibitors serine palmitoyltransferase inhibitor serine palmitoyltransferase inhibitors EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor EC 2.4.1.16 (chitin synthase) inhibitor EC 2.4.1.16 (chitin synthase) inhibitors EC 2.4.1.16 inhibitor EC 2.4.1.16 inhibitors UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitor UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitors chitin synthase (EC 2.4.1.16) inhibitor chitin synthase (EC 2.4.1.16) inhibitors chitin synthase inhibitor chitin synthase inhibitors chitin synthesis inhibitor chitin synthesis inhibitors chitin synthetase inhibitor chitin synthetase inhibitors chitin-UDP N-acetylglucosaminyltransferase inhibitor chitin-UDP N-acetylglucosaminyltransferase inhibitors chitin-UDP acetyl-glucosaminyl transferase inhibitor chitin-UDP acetyl-glucosaminyl transferase inhibitors chitin-uridine diphosphate acetylglucosaminyltransferase inhibitor chitin-uridine diphosphate acetylglucosaminyltransferase inhibitors trans-N-acetylglucosaminosylase inhibitor trans-N-acetylglucosaminosylase inhibitors EC 2.4.1.16 (chitin synthase) inhibitor vasopressin receptor antagonist antidiuretic hormone inhibitor antidiuretic hormone inhibitors arginine vasopressin receptor antagonist arginine vasopressin receptor antagonists argipressin receptor antagonist argipressin receptor antagonists vasopressin receptor antagonists vasopressin receptor antagonist antipruritic drug anti-itching drug anti-itching drugs antipruritic agent antipruritic agents antipruritic drugs antipruritic drug vasopressin receptor agonist antidiuretic hormone agonist antidiuretic hormone agonists arginine vasopressin receptor agonist arginine vasopressin receptor agonists argipressin receptor agonist argipressin receptor agonists vasopressin receptor agonists vasopressin receptor agonist electrophilic reagent electrophile electrophiles electrophilic reagents electrophilic reagent nucleophilic reagent nucleophile nucleophiles nucleophilic reagents nucleophilic reagent chromatographic reagent derivatising reagents derivatizing reagent derivatizing reagents chromatographic reagent bolaamphiphile alpha-omega-type surfactant bolaamphiphiles bolaform surfactant bolaphile bolaamphiphile progestin progestins progestin antihyperplasia drug antihypergenesis drug antihypergenesis drugs antihyperplasia drugs antihyperplastic antihyperplasia drug depigmentation drug depigmentation agent depigmentation agents depigmentation drugs depigmentor depigmentors depigmentation drug HIV fusion inhibitor HIV entry inhibitor HIV entry inhibitors HIV fusion inhibitors HIV fusion inhibitor EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor DNA nucleotidyltransferase (RNA-directed) inhibitor DNA nucleotidyltransferase (RNA-directed) inhibitors EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors EC 2.7.7.49 inhibitor EC 2.7.7.49 inhibitors RNA revertase inhibitor RNA revertase inhibitors RNA-dependent DNA polymerase inhibitor RNA-dependent DNA polymerase inhibitors RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors RNA-directed DNA polymerase inhibitor RNA-directed DNA polymerase inhibitors RNA-instructed DNA polymerase inhibitor RNA-instructed DNA polymerase inhibitors RT inhibitor RT inhibitors deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors reverse transcriptase inhibitor reverse transcriptase inhibitors revertase inhibitor revertase inhibitors telomerase inhibitor telomerase inhibitors EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor amphiphile amphiphiles amphiphile EC 1.14.18.1 (tyrosinase) inhibitor EC 1.14.18.1 (tyrosinase) inhibitors EC 1.14.18.1 inhibitor EC 1.14.18.1 inhibitors L-tyrosine,L-dopa:oxygen oxidoreductase inhibitor L-tyrosine,L-dopa:oxygen oxidoreductase inhibitors NN-acetyl-6-hydroxytryptophan oxidase inhibitor NN-acetyl-6-hydroxytryptophan oxidase inhibitors O-diphenol:O2 oxidoreductase inhibitor O-diphenol:O2 oxidoreductase inhibitors cresolase inhibitor cresolase inhibitors monophenol dihydroxyphenylalanine:oxygen oxidoreductase inhibitor monophenol dihydroxyphenylalanine:oxygen oxidoreductase inhibitors monophenol monooxidase inhibitor monophenol monooxidase inhibitors monophenol monooxygenase inhibitor monophenol monooxygenase inhibitors monophenol oxidase inhibitor monophenol oxidase inhibitors monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase inhibitor monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase inhibitors monophenolase inhibitor monophenolase inhibitors phenol oxidase inhibitor phenol oxidase inhibitors phenolase inhibitor phenolase inhibitors tyrosinase (EC 1.14.18.1) inhibitor tyrosinase (EC 1.14.18.1) inhibitors tyrosinase inhibitor tyrosinase inhibitors tyrosine-dopa oxidase inhibitor tyrosine-dopa oxidase inhibitors EC 1.14.18.1 (tyrosinase) inhibitor EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor ATP phosphohydrolase (Ca(2+)-transporting) inhibitor ATP phosphohydrolase (Ca(2+)-transporting) inhibitors Ca(2+)-pumping ATPase inhibitor Ca(2+)-pumping ATPase inhibitors Ca(2+)-transporting ATPase (EC 3.6.3.8) inhibitor Ca(2+)-transporting ATPase (EC 3.6.3.8) inhibitors Ca(2+)-transporting ATPase inhibitor Ca(2+)-transporting ATPase inhibitors EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitors SERCA inhibitor SERCA inhibitors calcium pump inhibitor calcium pump inhibitors plasma membrane Ca-ATPase inhibitor plasma membrane Ca-ATPase inhibitors sarco(endo)plasmic reticulum Ca(2+)-ATPase inhibitor sarco(endo)plasmic reticulum Ca(2+)-ATPase inhibitors sarcoplasmic reticulum ATPase inhibitor sarcoplasmic reticulum ATPase inhibitors EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor mimotope antigenic determinant mimic epitope mimic mimeotope mimeotope function mimeotope role mimetope mimotope function mimotope role mimotope EC 3.4.* (hydrolases acting on peptide bond) inhibitor EC 3.4.* (hydrolase acting on peptide bond) inhibitor EC 3.4.* (hydrolase acting on peptide bonds) inhibitors EC 3.4.* (hydrolases acting on peptide bond) inhibitors EC 3.4.* (peptidase) inhibitor EC 3.4.* (peptidase) inhibitors EC 3.4.* inhibitor EC 3.4.* inhibitors inhibitor of hydrolases acting on peptide bond (EC 3.4.*) inhibitors of hydrolases acting on peptide bond (EC 3.4.*) peptidase inhibitors protease inhibitor protease inhibitors EC 3.4.* (hydrolases acting on peptide bond) inhibitor EC 3.5.1.2 (glutaminase) inhibitor EC 3.5.1.2 (glutaminase) inhibitors EC 3.5.1.2 inhibitor EC 3.5.1.2 inhibitors L-glutaminase inhibitor L-glutaminase inhibitors L-glutamine amidohydrolase inhibitor L-glutamine amidohydrolase inhibitors glutaminase (EC 3.5.1.2) inhibitor glutaminase (EC 3.5.1.2) inhibitors glutaminase I inhibitor glutaminase I inhibitors glutaminase inhibitor glutaminase inhibitors glutamine aminohydrolase inhibitor glutamine aminohydrolase inhibitors EC 3.5.1.2 (glutaminase) inhibitor thyroid hormone thyroid hormones thyroid hormone phenoxy herbicide phenoxy herbicides phenoxy herbicide opioid agent opioid agents opioid agent mu-opioid agent mu-opioid agents mu-opioid agent delta-opioid agent delta-opioid agents delta-opioid agent kappa-opioid agent kappa-opioid agents kappa-opioid agent opioid receptor antagonist opiate antagonist opiate antagonists opioid antagonist opioid antagonists opioid receptor antagonists opioid receptor antagonist opioid receptor agonist opiate agonist opiate agonists opioid agonist opioid agonists opioid receptor agonists opioid receptor agonist NMDA receptor antagonist N-methyl-D-aspartate receptor antagonist N-methyl-D-aspartate receptor antagonists NMDA receptor antagonists NMDAR antagonist NMDAR antagonists NMDA receptor antagonist chiral reagent chiral reagent glucagon receptor antagonist glucagon receptor antagonists glucagon receptor antagonist EC 4.2.1.20 (tryptophan synthase) inhibitor EC 4.2.1.20 (tryptophan synthase) inhibitors EC 4.2.1.20 inhibitor EC 4.2.1.20 inhibitors L-serine hydro-lyase (adding indoleglycerol-phosphate) inhibitor L-serine hydro-lyase (adding indoleglycerol-phosphate) inhibitors L-tryptophan synthetase inhibitor L-tryptophan synthetase inhibitors indoleglycerol phosphate aldolase inhibitor indoleglycerol phosphate aldolase inhibitors tryptophan desmolase inhibitor tryptophan desmolase inhibitors tryptophan synthase (EC 4.2.1.20) inhibitor tryptophan synthase (EC 4.2.1.20) inhibitors tryptophan synthase inhibitor tryptophan synthase inhibitors tryptophan synthetase inhibitor tryptophan synthetase inhibitors EC 4.2.1.20 (tryptophan synthase) inhibitor affinity label affinity labels affinity label excitatory amino acid antagonist EAA receptor antagonist EAA receptor antagonists excitatory amino acid antagonists excitatory amino acid receptor antagonist excitatory amino acid receptor antagonists excitatory amino acid antagonist anaesthesia adjuvant anaesthesia adjuvants anaesthestic adjuvant anaesthestic adjuvants anaesthesia adjuvant adjuvant adjuvants adjuvant immunogen immunogen tubulin modulator tubulin modulators tubulin modulator EC 2.5.1.9 (riboflavin synthase) inhibitor 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase inhibitor 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase inhibitors EC 2.5.1.9 (riboflavin synthase) inhibitors EC 2.5.1.9 inhibitor EC 2.5.1.9 inhibitors heavy riboflavin synthase inhibitor heavy riboflavin synthase inhibitors light riboflavin synthase inhibitor light riboflavin synthase inhibitors riboflavin synthase (EC 2.5.1.9) inhibitor riboflavin synthase (EC 2.5.1.9) inhibitors riboflavin synthase inhibitor riboflavin synthase inhibitors riboflavin synthetase inhibitor riboflavin synthetase inhibitors riboflavine synthase inhibitor riboflavine synthase inhibitors riboflavine synthetase inhibitor riboflavine synthetase inhibitors EC 2.5.1.9 (riboflavin synthase) inhibitor nephrotoxin nephrotoxins nephrotoxin angiotensin receptor antagonist angiotensin receptor antagonists angiotensin receptor antagonist bile therapy drug bile therapy agent bile therapy agents bile therapy drugs bile therapy drug EC 3.5.1.98 (histone deacetylase) inhibitor EC 3.5.1.98 (histone deacetylase) inhibitors EC 3.5.1.98 inhibitor EC 3.5.1.98 inhibitors HDAC inhibitor HDAC inhibitors HDACi HDACis HDI HDIs histone amidohydrolase inhibitor histone amidohydrolase inhibitors histone deacetylase (EC 3.5.1.98) inhibitor histone deacetylase (EC 3.5.1.98) inhibitors histone deacetylase inhibitor histone deacetylase inhibitors EC 3.5.1.98 (histone deacetylase) inhibitor inositol phosphorylceramide synthase inhibitor inositol phosphorylceramide synthase inhibitor EC 1.14.13.39 (nitric oxide synthase) inhibitor EC 1.14.13.39 (nitric oxide synthase) inhibitors EC 1.14.13.39 inhibitor EC 1.14.13.39 inhibitors NADPH-diaphorase inhibitor NADPH-diaphorase inhibitors NO synthase inhibitor NO synthase inhibitors endothelium-derived relaxation factor-forming enzyme inhibitor endothelium-derived relaxation factor-forming enzyme inhibitors endothelium-derived relaxing factor synthase inhibitor endothelium-derived relaxing factor synthase inhibitors nitric oxide synthase (EC 1.14.13.39) inhibitor nitric oxide synthase (EC 1.14.13.39) inhibitors nitric oxide synthase inhibitor nitric oxide synthase inhibitors nitric oxide synthetase inhibitor nitric oxide synthetase inhibitors nitric-oxide synthetase inhibitor nitric-oxide synthetase inhibitors EC 1.14.13.39 (nitric oxide synthase) inhibitor microtubule-stabilising agent microtubule stabilising agent microtubule stabilising role microtubule stabilizing agent microtubule stabilizing agents microtubule stabilizing role microtubule-stabilising agents microtubule-stabilizing agent microtubule-stabilising agent microtubule-destabilising agent microtubule destabilising agent microtubule destabilising agents microtubule destabilising role microtubule destabilizing role microtubule-destabilising agents microtubule-destabilizing agent microtubule-destabilizing agents microtubule-destabilising agent metabotropic glutamate receptor agonist mGluRs agonist metabotropic glutamate receptor agonists metabotropic glutamate receptor agonist acyl donor acyl donor EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitors EC 1.4.7.1 inhibitor EC 1.4.7.1 inhibitors L-glutamate:ferredoxin oxidoreductase (transaminating) inhibitor L-glutamate:ferredoxin oxidoreductase (transaminating) inhibitors ferredoxin-dependent glutamate synthase inhibitor ferredoxin-dependent glutamate synthase inhibitors ferredoxin-glutamate synthase inhibitor ferredoxin-glutamate synthase inhibitors glutamate synthase (ferredoxin) (EC 1.4.7.1) inhibitor glutamate synthase (ferredoxin) (EC 1.4.7.1) inhibitors glutamate synthase (ferredoxin) inhibitor glutamate synthase (ferredoxin) inhibitors glutamate synthase (ferredoxin-dependent) inhibitor glutamate synthase (ferredoxin-dependent) inhibitors glutamate synthase inhibitor glutamate synthase inhibitors EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor allelochemical allelochemicals allelochemical EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor AATK inhibitor AATYK inhibitor AATYK2 inhibitor AATYK3 inhibitor ACH inhibitor ALK inhibitor ALK inhibitors ARK inhibitor ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitor ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitors AXL inhibitor BRT inhibitor Bek inhibitor Bfgfr inhibitor Bsk inhibitor C-FMS inhibitor CAK inhibitor CCK4 inhibitor CD115 inhibitor CD135 inhibitor CDw135 inhibitor CFD1 inhibitor CKIT inhibitor CSF1R inhibitor Cek1 inhibitor Cek10 inhibitor Cek11 inhibitor Cek2 inhibitor Cek3 inhibitor Cek5 inhibitor Cek6 inhibitor Cek7 inhibitor DAlk inhibitor DDR1 inhibitor DDR2 inhibitor DKFZp434C1418 inhibitor DRT inhibitor DTK inhibitor Dek inhibitor Drosophila Eph kinase inhibitor EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitors EC 2.7.10.1 inhibitor EC 2.7.10.1 inhibitors ECK inhibitor EDDR1 inhibitor EGFR inhibitor EPH inhibitor EPHA1 inhibitor EPHA2 inhibitor EPHA6 inhibitor EPHA7 inhibitor EPHA8 inhibitor EPHB1 inhibitor EPHB2 inhibitor EPHB3 inhibitor EPHB4 inhibitor EPHT inhibitor EPHT2 inhibitor EPHT3 inhibitor EPHX inhibitor ERBB inhibitor ERBB1 inhibitor ERBB2 inhibitor ERBB3 inhibitor ERBB4 inhibitor ERK inhibitor Ebk inhibitor Eek inhibitor Ehk2 inhibitor Ehk3 inhibitor Elk inhibitor EphB5 inhibitor Eyk inhibitor FGFR1 inhibitor FGFR2 inhibitor FGFR3 inhibitor FGFR4 inhibitor FLG inhibitor FLK1 inhibitor FLK2 inhibitor FLT1 inhibitor FLT2 inhibitor FLT3 inhibitor FLT4 inhibitor FMS inhibitor Fv2 inhibitor HBGFR inhibitor HEK11 inhibitor HEK2 inhibitor HEK3 inhibitor HEK5 inhibitor HEK6 inhibitor HEP inhibitor HER2 inhibitor HER3 inhibitor HER4 inhibitor HGFR inhibitor HSCR1 inhibitor HTK inhibitor IGF1R inhibitor INSR inhibitor INSRR inhibitor IR inhibitor IRR inhibitor JTK12 inhibitor JTK13 inhibitor JTK14 inhibitor JWS inhibitor K-SAM inhibitor KDR inhibitor KGFR inhibitor KIA0641 inhibitor KIAA1079 inhibitor KIAA1459 inhibitor KIT inhibitor KLG inhibitor Kil inhibitor Kin15 inhibitor Kin16 inhibitor LTK inhibitor MCF3 inhibitor MEN2A/B inhibitor MER inhibitor MERTK inhibitor MEhk1 inhibitor MST1R inhibitor MTC1 inhibitor MUSK inhibitor Mdk1 inhibitor Mdk2 inhibitor Mdk5 inhibitor Mep inhibitor Mlk1 inhibitor Mlk2 inhibitor Mrk inhibitor Myk1 inhibitor N-SAM inhibitor NEP inhibitor NET inhibitor NGL inhibitor NOK inhibitor NTRK1 inhibitor NTRK2 inhibitor NTRK3 inhibitor NTRK4 inhibitor NTRKR1 inhibitor NTRKR2 inhibitor NTRKR3 inhibitor NYK inhibitor Neu inhibitor Nsk2 inhibitor Nuk inhibitor PCL inhibitor PDGFR inhibitor PDGFRA inhibitor PDGFRB inhibitor PHB6 inhibitor PTK inhibitor PTK3 inhibitor PTK7 inhibitor RET inhibitor RON inhibitor ROR1 inhibitor ROR2 inhibitor ROS1 inhibitor RSE inhibitor RTK inhibitor RYK inhibitor SEA inhibitor SKY inhibitor STK inhibitor STK1 inhibitor Sek2 inhibitor Sek3 inhibitor Sek4 inhibitor Sfr inhibitor TEK inhibitor TIE inhibitor TIE1 inhibitor TIE2 inhibitor TIF inhibitor TKT inhibitor TRK inhibitor TRKA inhibitor TRKB inhibitor TRKC inhibitor TRKE inhibitor TYK1 inhibitor TYRO10 inhibitor TYRO3 inhibitor TYRO7 inhibitor Tyro11 inhibitor Tyro5 inhibitor Tyro6 inhibitor UFO inhibitor VEGFR1 inhibitor VEGFR2 inhibitor VEGFR3 inhibitor Vik inhibitor YK1 inhibitor Yrk inhibitor anaplastic lymphoma kinase inhibitor anaplastic lymphoma kinase inhibitors ephrin-B3 receptor tyrosine kinase inhibitor insulin receptor protein-tyrosine kinase inhibitor neurite outgrowth regulating kinase inhibitor nork inhibitor novel oncogene with kinase-domain inhibitor receptor protein tyrosine kinase inhibitor receptor protein-tyrosine kinase (EC 2.7.10.1) inhibitor receptor protein-tyrosine kinase (EC 2.7.10.1) inhibitors receptor protein-tyrosine kinase inhibitor receptor protein-tyrosine kinase inhibitors EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor signalling molecule signal molecule signal molecules signaling molecule signaling molecules signalling molecules signalling molecule EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitor EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitors EC 2.3.1.24 inhibitor EC 2.3.1.24 inhibitors acyl-CoA:sphingosine N-acyltransferase inhibitor acyl-CoA:sphingosine N-acyltransferase inhibitors ceramide synthase inhibitor ceramide synthase inhibitors ceramide synthetase inhibitor ceramide synthetase inhibitors sphingosine N-acyltransferase (EC 2.3.1.24) inhibitor sphingosine N-acyltransferase (EC 2.3.1.24) inhibitors sphingosine N-acyltransferase inhibitor sphingosine N-acyltransferase inhibitors sphingosine acyltransferase inhibitor sphingosine acyltransferase inhibitors EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitor EC 4.2.1.3 (aconitate hydratase) inhibitor 2-methylaconitate hydratase inhibitor 2-methylaconitate hydratase inhibitors 4.2.1.3 inhibitor 4.2.1.3 inhibitors AcnB inhibitor AcnB inhibitors EC 4.2.1.3 (aconitate hydratase) inhibitors aconitase inhibitor aconitase inhibitors aconitate hydratase (EC 4.2.1.3) inhibitor aconitate hydratase (EC 4.2.1.3) inhibitors aconitate hydratase inhibitor aconitate hydratase inhibitors cis-aconitase inhibitor cis-aconitase inhibitors citrate hydro-lyase inhibitor citrate hydro-lyase inhibitors citrate(isocitrate) hydro-lyase (cis-aconitate-forming) inhibitor citrate(isocitrate) hydro-lyase (cis-aconitate-forming) inhibitors citrate(isocitrate) hydro-lyase inhibitor citrate(isocitrate) hydro-lyase inhibitors EC 4.2.1.3 (aconitate hydratase) inhibitor EC 3.11.1.3 (phosphonopyruvate hydrolase) inhibitor EC 3.11.1.3 (phosphonopyruvate hydrolase) inhibitors EC 3.11.1.3 inhibitor EC 3.11.1.3 inhibitors PPH inhibitor PPH inhibitors phosphonopyruvate hydrolase (EC 3.11.1.3) inhibitor phosphonopyruvate hydrolase (EC 3.11.1.3) inhibitors phosphonopyruvate hydrolase inhibitor phosphonopyruvate hydrolase inhibitors EC 3.11.1.3 (phosphonopyruvate hydrolase) inhibitor glycine receptor antagonist glycine receptor antagonists glycine receptor antagonist fuel additive fuel additives fuel enhancer fuel additive hepatoprotective agent antihepatotoxic agent hepatoprotective agents hepatoprotector hepatoprotective agent EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitors EC 4.3.1.24 inhibitor EC 4.3.1.24 inhibitors L-phenylalanine ammonia-lyase (trans-cinnamate-forming) inhibitor L-phenylalanine ammonia-lyase (trans-cinnamate-forming) inhibitors L-phenylalanine ammonia-lyase inhibitor L-phenylalanine ammonia-lyase inhibitors PAL inhibitor PAL inhibitors Phe ammonia-lyase inhibitor Phe ammonia-lyase inhibitors phenylalanine ammonia-lyase (EC 4.3.1.24) inhibitor phenylalanine ammonia-lyase (EC 4.3.1.24) inhibitors phenylalanine ammonia-lyase inhibitor phenylalanine ammonia-lyase inhibitors phenylalanine ammonium-lyase inhibitor phenylalanine ammonium-lyase inhibitors phenylalanine deaminase inhibitor phenylalanine deaminase inhibitors EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor EC 1.2.3.1 (aldehyde oxidase) inhibitor EC 1.2.3.1 (aldehyde oxidase) inhibitors EC 1.2.3.1 inhibitor EC 1.2.3.1 inhibitors aldehyde oxidase (EC 1.2.3.1) inhibitor aldehyde oxidase (EC 1.2.3.1) inhibitors aldehyde oxidase inhibitor aldehyde oxidase inhibitors aldehyde:oxygen oxidoreductase inhibitor aldehyde:oxygen oxidoreductase inhibitors quinoline oxidase inhibitor quinoline oxidase inhibitors retinal oxidase inhibitor retinal oxidase inhibitors retinoic acid synthase inhibitor retinoic acid synthase inhibitors EC 1.2.3.1 (aldehyde oxidase) inhibitor odorant receptor agonist odorant receptor agonist tankyrase inhibitor tankyrase inhibitors tankyrase inhibitor EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor ADP-ribosyltransferase (polymerising) inhibitor ADP-ribosyltransferase (polymerising) inhibitors ADP-ribosyltransferase (polymerizing) inhibitor ADP-ribosyltransferase (polymerizing) inhibitors EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitors EC 2.4.2.30 inhibitor EC 2.4.2.30 inhibitors NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitor NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitors NAD(+) ADP-ribosyltransferase inhibitor NAD(+) ADP-ribosyltransferase inhibitors NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors PARP PARPs poly(ADP-ribose) polymerase inhibitor poly(ADP-ribose) polymerase inhibitors poly(ADP-ribose) synthase inhibitor poly(ADP-ribose) synthase inhibitors poly(ADP-ribose) synthetase inhibitor poly(ADP-ribose) synthetase inhibitors poly(adenosine diphosphate ribose) polymerase inhibitor poly(adenosine diphosphate ribose) polymerase inhibitors EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor axin stabilizer axin stabilizer sialyltransferase inhibitor sialyltransferase inhibitors sialyltransferase inhibitor emulsifier emulgent emulgents emulsifiers emulsifier food emulsifier food emulsifiers food emulsifier osteogenesis regulator osteogenesis regulators osteogenesis regulator phase-transfer catalyst PTC phase transfer catalyst phase transfer catalysts phase-transfer catalysts phase-transfer catalyst crystallisation adjutant crystallisation adjutants crystallization adjutant crystallization adjutants crystallisation adjutant EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitors EC 2.4.2.1 inhibitor EC 2.4.2.1 inhibitors PNPase inhibitor PNPase inhibitors PUNPI inhibitor PUNPI inhibitors PUNPII inhibitor PUNPII inhibitors inosine phosphorylase inhibitor inosine phosphorylase inhibitors inosine-guanosine phosphorylase inhibitor inosine-guanosine phosphorylase inhibitors nucleotide phosphatase inhibitor nucleotide phosphatase inhibitors purine deoxynucleoside phosphorylase inhibitor purine deoxynucleoside phosphorylase inhibitors purine deoxyribonucleoside phosphorylase inhibitor purine deoxyribonucleoside phosphorylase inhibitors purine nucleoside phosphorylase inhibitor purine nucleoside phosphorylase inhibitors purine ribonucleoside phosphorylase inhibitor purine ribonucleoside phosphorylase inhibitors purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitor purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitors purine-nucleoside phosphorylase inhibitor purine-nucleoside phosphorylase inhibitors purine-nucleoside:phosphate ribosyltransferase inhibitor purine-nucleoside:phosphate ribosyltransferase inhibitors EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor sphingosine-1-phosphate receptor agonist EDG receptor agonist S1P receptor agonist S1P receptor agonists SIP agonist SIP agonists sphingosine 1-phosphate receptor agonist sphingosine 1-phosphate receptor agonists sphingosine-1-phosphate receptor agonists sphingosine-1-phosphate receptor agonist insulin release inhibitor insulin release inhibitor EC 1.1.3.13 (alcohol oxidase) inhibitor EC 1.1.3.13 (alcohol oxidase) inhibitors EC 1.1.3.13 inhibitor EC 1.1.3.13 inhibitors alcohol oxidase (EC 1.1.3.13) inhibitor alcohol oxidase (EC 1.1.3.13) inhibitors alcohol oxidase inhibitor alcohol oxidase inhibitors alcohol:oxygen oxidoreductase inhibitor alcohol:oxygen oxidoreductase inhibitors ethanol oxidase inhibitor ethanol oxidase inhibitors EC 1.1.3.13 (alcohol oxidase) inhibitor EC 4.2.1.22 (cystathionine beta-synthase) inhibitor EC 4.2.1.22 (cystathionine beta-synthase) inhibitors EC 4.2.1.22 inhibitor EC 4.2.1.22 inhibitors L-serine hydro-lyase (adding homocysteine) inhibitor L-serine hydro-lyase (adding homocysteine) inhibitors L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) inhibitor L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) inhibitors beta-thionase inhibitor beta-thionase inhibitors cystathionine beta-synthase (EC 4.2.1.22) inhibitor cystathionine beta-synthase (EC 4.2.1.22) inhibitors cystathionine beta-synthase inhibitor cystathionine beta-synthase inhibitors cystathionine-beta-synthase inhibitor cystathionine-beta-synthase inhibitors cysteine synthase inhibitor cysteine synthase inhibitors methylcysteine synthase inhibitor methylcysteine synthase inhibitors serine sulfhydrase inhibitor serine sulfhydrase inhibitors serine sulfhydrylase inhibitor serine sulfhydrylase inhibitors EC 4.2.1.22 (cystathionine beta-synthase) inhibitor EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor CPT I (outer membrane carnitine palmitoyl transferase) inhibitor CPT I (outer membrane carnitine palmitoyl transferase) inhibitors CPT inhibitor CPT inhibitors CPT-A inhibitor CPT-A inhibitors CPT-B inhibitor CPT-B inhibitors CPTi inhibitor CPTi inhibitors CPTo inhibitor CPTo inhibitors CTP-1 inhibitor CTP-1 inhibitors EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitors EC 2.3.1.21 inhibitor EC 2.3.1.21 inhibitors L-carnitine palmitoyltransferase inhibitor L-carnitine palmitoyltransferase inhibitors acylcarnitine transferase inhibitor acylcarnitine transferase inhibitors carnitine O-palmitoyltransferase (EC 2.3.1.21) inhibitor carnitine O-palmitoyltransferase (EC 2.3.1.21) inhibitors carnitine O-palmitoyltransferase inhibitor carnitine O-palmitoyltransferase inhibitors carnitine palmitoyltransferase II inhibitor carnitine palmitoyltransferase II inhibitors carnitine palmitoyltransferase inhibitor carnitine palmitoyltransferase inhibitors carnitine palmitoyltransferase-1 inhibitor carnitine palmitoyltransferase-1 inhibitors carnitine palmitoyltransferase-A inhibitor carnitine palmitoyltransferase-A inhibitors mitochondrial carnitine palmitoyltransferase-1 inhibitor mitochondrial carnitine palmitoyltransferase-1 inhibitors outer malonyl-CoA inhibitable carnitine palmitoyltransferase inhibitor outer malonyl-CoA inhibitable carnitine palmitoyltransferase inhibitors palmitoyl-CoA:L-carnitine O-palmitoyltransferase inhibitor palmitoyl-CoA:L-carnitine O-palmitoyltransferase inhibitors palmitoylcarnitine transferase inhibitor palmitoylcarnitine transferase inhibitors EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor T-cell proliferation inhibitor T-cell proliferation inhibitors T-cell proliferation inhibitor peptidomimetic peptidomimetics peptidomimetic reducing agent reducer reducers reducing agents reductant reductants reducing agent oxidising agent oxidant oxidants oxidiser oxidisers oxidising agents oxidizer oxidizers oxidizing agent oxidizing agents oxidising agent sodium-dependent Pi-transporter inhibitor NPC inhibitor Na-Pi inhibitor sodium-dependent inorganic phosphate cotransporter inhibitor sodium-dependent inorganic phosphate transporter inhibitor sodium-dependent Pi-transporter inhibitor EC 3.1.3.1 (alkaline phosphatase) inhibitor EC 3.1.3.1 (alkaline phosphatase) inhibitors EC 3.1.3.1 inhibitor EC 3.1.3.1 inhibitors alkaline phenyl phosphatase inhibitor alkaline phenyl phosphatase inhibitors alkaline phosphatase (EC 3.1.3.1) inhibitor alkaline phosphatase (EC 3.1.3.1) inhibitors alkaline phosphatase inhibitor alkaline phosphatase inhibitors alkaline phosphohydrolase inhibitor alkaline phosphohydrolase inhibitors alkaline phosphomonoesterase inhibitor alkaline phosphomonoesterase inhibitors glycerophosphatase inhibitor glycerophosphatase inhibitors orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitor orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitors phosphate-monoester phosphohydrolase (alkaline optimum) inhibitor phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors phosphomonoesterase inhibitor phosphomonoesterase inhibitors EC 3.1.3.1 (alkaline phosphatase) inhibitor fibroblast growth factor receptor antagonist FGFR inhibitor FGFR inhibitors fibroblast growth factor receptor antagonists fibroblast growth factor receptor inhibitor fibroblast growth factor receptor inhibitors fibroblast growth factor receptor antagonist explosive explosive compound explosive compounds explosive material explosives explosives chemical explosives chemicals explosive EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitors EC 3.6.3.9 inhibitor EC 3.6.3.9 inhibitors Na(+)/K(+)-ATPase inhibitor Na(+)/K(+)-ATPase inhibitors Na(+)/K(+)-pump inhibitor Na(+)/K(+)-pump inhibitors Na(+)/K(+)-transporting ATPase (EC 3.6.3.9) inhibitor Na(+)/K(+)-transporting ATPase (EC 3.6.3.9) inhibitors Na(+)/K(+)-transporting ATPase inhibitor Na(+)/K(+)-transporting ATPase inhibitors sodium pump inhibitor sodium pump inhibitors sodium-potassium adenosine triphosphatase inhibitor sodium-potassium adenosine triphosphatase inhibitors sodium-potassium pump inhibitor sodium-potassium pump inhibitors EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor gonadotropin releasing hormone agonist GnRH agonist GnRH agonists GnRH-A gonadotrophin releasing hormone agonist gonadotrophin releasing hormone agonists gonadotropin releasing hormone agonists gonadotropin releasing hormone agonist glucocorticoid receptor agonist glucocorticoid receptor agonists glucocorticoid receptor agonist chemokine receptor 5 antagonist C-C chemokine receptor 5 antagonist C-C chemokine receptor 5 antagonists CCR-5 antagonist CCR-5 antagonists CCR5 antagonist CCR5 antagonists chemokine receptor 5 antagonists chemokine receptor 5 antagonist EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor 4-aminobutanoate:2-oxoglutarate aminotransferase inhibitor 4-aminobutanoate:2-oxoglutarate aminotransferase inhibitors 4-aminobutyrate aminotransferase inhibitor 4-aminobutyrate aminotransferase inhibitors 4-aminobutyrate transaminase inhibitor 4-aminobutyrate transaminase inhibitors 4-aminobutyrate--2-ketoglutarate aminotransferase inhibitor 4-aminobutyrate--2-ketoglutarate aminotransferase inhibitors 4-aminobutyrate--2-oxoglutarate aminotransferase inhibitor 4-aminobutyrate--2-oxoglutarate aminotransferase inhibitors 4-aminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.19) inhibitor 4-aminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.19) inhibitors 4-aminobutyrate--2-oxoglutarate transaminase inhibitor 4-aminobutyrate--2-oxoglutarate transaminase inhibitors 4-aminobutyrate-2-oxoglutarate transaminase inhibitor 4-aminobutyrate-2-oxoglutarate transaminase inhibitors 4-aminobutyric acid 2-ketoglutaric acid aminotransferase inhibitor 4-aminobutyric acid 2-ketoglutaric acid aminotransferase inhibitors 4-aminobutyric acid aminotransferase inhibitor 4-aminobutyric acid aminotransferase inhibitors EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitors EC 2.6.1.19 inhibitor EC 2.6.1.19 inhibitors GABA aminotransferase inhibitor GABA aminotransferase inhibitors GABA transaminase inhibitor GABA transaminase inhibitors GABA transferase inhibitor GABA transferase inhibitors GABA--2-oxoglutarate aminotransferase inhibitor GABA--2-oxoglutarate aminotransferase inhibitors GABA--2-oxoglutarate transaminase inhibitor GABA--2-oxoglutarate transaminase inhibitors GABA--alpha-ketoglutarate aminotransferase inhibitors GABA--alpha-ketoglutarate transaminase inhibitor GABA--alpha-ketoglutarate transaminase inhibitors GABA--alpha-ketoglutaric acid transaminase inhibitor GABA--alpha-ketoglutaric acid transaminase inhibitors GABA--alpha-oxoglutarate aminotransferase inhibitor GABA--alpha-oxoglutarate aminotransferase inhibitors GABA--oxoglutarate aminotransferase inhibitor GABA--oxoglutarate aminotransferase inhibitors GABA--oxoglutarate transaminase inhibitor GABA--oxoglutarate transaminase inhibitors GabT inhibitor GabT inhibitors aminobutyrate aminotransferase inhibitor aminobutyrate aminotransferase inhibitors aminobutyrate transaminase inhibitor aminobutyrate transaminase inhibitors beta-alanine aminotransferase inhibitor beta-alanine aminotransferase inhibitors beta-alanine--oxoglutarate aminotransferase inhibitor beta-alanine--oxoglutarate aminotransferase inhibitors beta-alanine--oxoglutarate transaminase inhibitor beta-alanine--oxoglutarate transaminase inhibitors gamma-amino-N-butyrate transaminase inhibitor gamma-amino-N-butyrate transaminase inhibitors gamma-aminobutyrate aminotransaminase inhibitor gamma-aminobutyrate aminotransaminase inhibitors gamma-aminobutyrate transaminase inhibitor gamma-aminobutyrate transaminase inhibitors gamma-aminobutyrate--alpha-ketoglutarate aminotransferase inhibitor gamma-aminobutyrate--alpha-ketoglutarate aminotransferase inhibitors gamma-aminobutyrate--alpha-ketoglutarate transaminase inhibitor gamma-aminobutyrate--alpha-ketoglutarate transaminase inhibitors gamma-aminobutyrate:alpha-oxoglutarate aminotransferase inhibitor gamma-aminobutyrate:alpha-oxoglutarate aminotransferase inhibitors gamma-aminobutyric acid aminotransferase inhibitor gamma-aminobutyric acid aminotransferase inhibitors gamma-aminobutyric acid pyruvate transaminase inhibitor gamma-aminobutyric acid pyruvate transaminase inhibitors gamma-aminobutyric acid transaminase inhibitor gamma-aminobutyric acid transaminase inhibitors gamma-aminobutyric acid--2-oxoglutarate transaminase inhibitor gamma-aminobutyric acid--2-oxoglutarate transaminase inhibitors gamma-aminobutyric acid--alpha-ketoglutarate transaminase inhibitor gamma-aminobutyric acid--alpha-ketoglutarate transaminase inhibitors gamma-aminobutyric acid--alpha-ketoglutaric acid aminotransferase inhibitor gamma-aminobutyric acid--alpha-ketoglutaric acid aminotransferase inhibitors gamma-aminobutyric transaminase inhibitor gamma-aminobutyric transaminase inhibitors glutamate--succinic semialdehyde transaminase inhibitor glutamate--succinic semialdehyde transaminase inhibitors EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor EC 2.1.1.45 (thymidylate synthase) inhibitor 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase inhibitor 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase inhibitors EC 2.1.1.45 (thymidylate synthase) inhibitors EC 2.1.1.45 inhibitor EC 2.1.1.45 inhibitors TMP synthetase inhibitor TMP synthetase inhibitors dTMP synthase inhibitor dTMP synthase inhibitors methylenetetrahydrofolate:dUMP C-methyltransferase inhibitor methylenetetrahydrofolate:dUMP C-methyltransferase inhibitors thymidylate synthase inhibitor thymidylate synthase inhibitors thymidylate synthetase inhibitor thymidylate synthetase inhibitors EC 2.1.1.45 (thymidylate synthase) inhibitor EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase inhibitors 2-amino-N-ribosylacetamide 5'-phosphate transformylase inhibitor 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase inhibitor 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase inhibitors EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitors EC 2.1.2.2 inhibitor EC 2.1.2.2 inhibitors GAR TFase inhibitor GAR TFase inhibitors GAR formyltransferase inhibitor GAR formyltransferase inhibitors GAR transformylase inhibitor GAR transformylase inhibitors glycinamide ribonucleotide formyltransferase inhibitor glycinamide ribonucleotide formyltransferase inhibitors glycinamide ribonucleotide transformylase inhibitor glycinamide ribonucleotide transformylase inhibitors phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) inhibitor phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) inhibitors phosphoribosylglycinamide formyltransferase inhibitor phosphoribosylglycinamide formyltransferase inhibitors EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor neuroprotective agent neuroprotectant neuroprotectants neuroprotective agents neuroprotective agent retinoid X receptor agonist retinoid X receptor agonists retinoid X receptor agonist film-forming compound film-forming agent film-forming agents film-forming compounds film-forming compound sclerotherapy agent sclerotherapy agents sclerotherapy agent EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitors EC 1.14.16.2 inhibitor EC 1.14.16.2 inhibitors L-tyrosine hydroxylase inhibitor L-tyrosine hydroxylase inhibitors L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) inhibitor L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) inhibitors tyrosine 3-hydroxylase inhibitor tyrosine 3-hydroxylase inhibitors tyrosine 3-monooxygenase (EC 1.14.16.2) inhibitor tyrosine 3-monooxygenase (EC 1.14.16.2) inhibitors tyrosine 3-monooxygenase inhibitor tyrosine 3-monooxygenase inhibitors tyrosine hydroxylase inhibitor tyrosine hydroxylase inhibitors EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor alpha1B-adrenoceptor antagonist alpha1B-adrenoceptor antagonists alpha1B-adrenoceptor antagonist estrogen receptor agonist estrogen receptor agonists estrogen receptor agonist adenosine A1 receptor antagonist adenosine A1 receptor antagonists adenosine A1 receptor antagonist cellulose synthesis inhibitor cellulose biosynthesis inhibitor cellulose biosynthesis inhibitors cellulose synthesis inhibitors cellulose synthesis inhibitor Hsp90 inhibitor Hsp90 inhibitors heat shock protein 90 inhibitor heat shock protein 90 inhibitors Hsp90 inhibitor metabotropic glutamate receptor antagonist mGluR antagonist mGluR antagonists metabotropic glutamate receptor antagonists metabotropic glutamate receptor antagonist protein kinase C agonist protein kinase C agonists protein kinase C agonist EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor EC 3.5.1.99 (fatty acid amide hydrolase) inhibitors EC 3.5.1.99 inhibitor EC 3.5.1.99 inhibitors FAAH inhibitor FAAH inhibitors anandamide amidohydrolase inhibitor anandamide amidohydrolase inhibitors arachidonoylethanolamide amidohydrolase inhibitor arachidonoylethanolamide amidohydrolase inhibitors fatty acid amide hydrolase (EC 3.5.1.99) inhibitor fatty acid amide hydrolase (EC 3.5.1.99) inhibitors fatty acid amide hydrolase inhibitor fatty acid amide hydrolase inhibitors fatty acylamide amidohydrolase inhibitor fatty acylamide amidohydrolase inhibitors oleamide hydrolase inhibitor oleamide hydrolase inhibitors EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor food additive food additives food additive food acidity regulator acidity regulator acidity regulators food acidity regulators pH control agent pH control agents food acidity regulator delta-opioid receptor agonist delta-opioid receptor agonist incretin mimetic incretin mimetics incretin mimetic AMPA receptor agonist AMPA receptor agonists AMPAR agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor agonist quisqualate receptor agonist AMPA receptor agonist protein kinase G agonist protein kinase G agonists protein kinase G agonist protein kinase agonist protein kinase agonists protein kinase agonist EC 2.5.1.58 (protein farnesyltransferase) inhibitor EC 2.5.1.58 (protein farnesyltransferase) inhibitors EC 2.5.1.58 inhibitor EC 2.5.1.58 inhibitors FTase inhibitor FTase inhibitors farnesyl transferase inhibitor farnesyl transferase inhibitors farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitor farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitors farnesyltransferase inhibitor farnesyltransferase inhibitors protein farnesyltransferase (EC 2.5.1.58) inhibitor protein farnesyltransferase (EC 2.5.1.58) inhibitors protein farnesyltransferase inhibitor protein farnesyltransferase inhibitors EC 2.5.1.58 (protein farnesyltransferase) inhibitor cysteine protease inhibitor cysteine protease inhibitors cysteine proteinase inhibitor cysteine proteinase inhibitors cysteine protease inhibitor H3-receptor agonist H3-receptor agonists histamine H3-receptor agonist histamine H3-receptor agonists H3-receptor agonist H4-receptor agonist H4-receptor agonists H4-receptor agonist H3-receptor antagonist H3-receptor antagonists histamine H3-receptor antagonist histamine H3-receptor antagonists H3-receptor antagonist EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitors EC 2.7.8.15 inhibitor EC 2.7.8.15 inhibitors GlcNAc-1-P transferase inhibitor GlcNAc-1-P transferase inhibitors N-acetylglucosamine phosphotransferase inhibitor N-acetylglucosamine transferase inhibitors N-acetylglucosamine-1-phosphate transferase inhibitor N-acetylglucosamine-1-phosphate transferase inhibitors UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitor UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitors UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitor UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitors UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitor UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitors UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitor UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitors UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitor UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitors UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitor UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitors UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitor UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitors UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitor UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitors chitobiosylpyrophosphoryldolichol synthase inhibitor chitobiosylpyrophosphoryldolichol synthase inhibitors dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitor dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitors uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitor uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitors EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor reaction intermediate chemical intermediate reaction intermediate K-ATP channel agonist ATP-sensitive K(+) channel agonist ATP-sensitive K(+) channel agonists ATP-sensitive K+ channel agonist ATP-sensitive K+ channel agonists ATP-sensitive K+ channel opener ATP-sensitive K+ channel openers K(ATP) channel agonist K(ATP) channel agonists K-ATP channel agonists K-ATP channel agonist MALDI matrix material 'matrix-assisted laser desorption/ionization' matrix material 'matrix-assisted laser desorption/ionization' matrix materials MALDI matrix materials MALDI matrix solution MALDI matrix solutions MALDI matrix material glutamate transporter activator excitatory amino-acid transporter activator excitatory amino-acid transporter activators glutamate transporter activators glutamate transporter activator neurotransmitter transporter modulator neurotransmitter transporter modulators neurotransmitter transporter modulator EC 3.4.22.38 (cathepsin K) inhibitor EC 3.4.22.38 (cathepsin K) inhibitors EC 3.4.22.38 inhibitor EC 3.4.22.38 inhibitors cathepsin K (EC 3.4.22.38) inhibitor cathepsin K (EC 3.4.22.38) inhibitors cathepsin K inhibitor cathepsin K inhibitors cathepsin O inhibitor cathepsin O inhibitors cathepsin O2 inhibitor cathepsin O2 inhibitors cathepsin X inhibitor cathepsin X inhibitors EC 3.4.22.38 (cathepsin K) inhibitor EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitor (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase inhibitor (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase inhibitors EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitors EC 2.5.1.29 inhibitor EC 2.5.1.29 inhibitors GGPP synthase inhibitor GGPP synthase inhibitors farnesyltransferase inhibitor farnesyltransferase inhibitors geranylgeranyl diphosphate synthase (EC 2.5.1.29) inhibitor geranylgeranyl diphosphate synthase (EC 2.5.1.29) inhibitors geranylgeranyl diphosphate synthase inhibitor geranylgeranyl diphosphate synthase inhibitors geranylgeranyl pyrophosphate synthase inhibitor geranylgeranyl pyrophosphate synthase inhibitors geranylgeranyl pyrophosphate synthetase inhibitor geranylgeranyl pyrophosphate synthetase inhibitors geranylgeranyl-PP synthetase inhibitor geranylgeranyl-PP synthetase inhibitors EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitor EC 1.3.1.43 (arogenate dehydrogenase) inhibitor EC 1.3.1.43 (arogenate dehydrogenase) inhibitors EC 1.3.1.43 inhibitor EC 1.3.1.43 inhibitors L-arogenate:NAD(+) oxidoreductase (decarboxylating) inhibitor L-arogenate:NAD(+) oxidoreductase (decarboxylating) inhibitors L-arogenate:NAD+ oxidoreductase (decarboxylating) inhibitor L-arogenate:NAD+ oxidoreductase (decarboxylating) inhibitors L-arogenate:NAD+ oxidoreductase inhibitor L-arogenate:NAD+ oxidoreductase inhibitors TyrA(a) inhibitor TyrA(a) inhibitors arogenate dehydrogenase (EC 1.3.1.43) inhibitor arogenate dehydrogenase (EC 1.3.1.43) inhibitors arogenate dehydrogenase inhibitor arogenate dehydrogenase inhibitors cyclohexadienyl dehydrogenase inhibitor cyclohexadienyl dehydrogenase inhibitors EC 1.3.1.43 (arogenate dehydrogenase) inhibitor monolignol monolignols monolignol EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitor 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitors EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitors EC 2.1.2.1 inhibitor EC 2.1.2.1 inhibitors L-serine hydroxymethyltransferase inhibitor L-serine hydroxymethyltransferase inhibitors L-threonine aldolase inhibitor L-threonine aldolase inhibitors allothreonine aldolase inhibitor allothreonine aldolase inhibitors glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitor glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitors glycine hydroxymethyltransferase inhibitor glycine hydroxymethyltransferase inhibitors serine aldolase inhibitor serine aldolase inhibitors serine hydroxymethylase inhibitor serine hydroxymethylase inhibitors serine hydroxymethyltransferase inhibitor serine hydroxymethyltransferase inhibitors serine transhydroxymethylase inhibitor serine transhydroxymethylase inhibitors threonine aldolase inhibitor threonine aldolase inhibitors EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor NMDA receptor agonist N-methyl-D-aspartate receptor agonist N-methyl-D-aspartate receptor agonists NMDA receptor agonists NMDAR agonist NMDAR agonists NMDA receptor agonist flour treatment agent dough improver dough improvers flour treatment agent improving agent improving agents flour treatment agent uremic toxin uremic toxins uremic toxin glycine transporter 1 inhibitor GlyT1 inhibitor GlyT1 inhibitors glycine transporter 1 inhibitors glycine transporter 1 inhibitor glycine receptor agonist glycine receptor agonists glycine receptor agonist EC 1.8.1.9 (thioredoxin reductase) inhibitor EC 1.8.1.9 (thioredoxin reductase) inhibitors EC 1.8.1.9 inhibitor EC 1.8.1.9 inhibitors NADP-thioredoxin reductase inhibitor NADP-thioredoxin reductase inhibitors NADPH-thioredoxin reductase inhibitor NADPH-thioredoxin reductase inhibitors NADPH2:oxidized thioredoxin oxidoreductase inhibitor NADPH2:oxidized thioredoxin oxidoreductase inhibitors TrxR inhibitor TrxR inhibitors thioredoxin reductase (EC 1.8.1.9) inhibitor thioredoxin reductase (EC 1.8.1.9) inhibitors thioredoxin reductase (NADPH) inhibitor thioredoxin reductase (NADPH) inhibitors thioredoxin reductase inhibitor thioredoxin reductase inhibitors thioredoxin-disulfide reductase inhibitor thioredoxin-disulfide reductase inhibitors thioredoxin:NADP+ oxidoreductase inhibitor thioredoxin:NADP+ oxidoreductase inhibitors EC 1.8.1.9 (thioredoxin reductase) inhibitor EC 2.3.1.26 (sterol O-acyltransferase) inhibitor ACAT inhibitor ACAT inhibitors EC 2.3.1.26 (sterol O-acyltransferase) inhibitors EC 2.3.1.26 inhibitor EC 2.3.1.26 inhibitors acyl coenzyme A-cholesterol-O-acyltransferase inhibitor acyl coenzyme A-cholesterol-O-acyltransferase inhibitors acyl-CoA:cholesterol O-acyltransferase inhibitor acyl-CoA:cholesterol acyltransferase inhibitor acyl-CoA:cholesterol acyltransferase inhibitors acylcoenzyme A:cholesterol O-acyltransferase inhibitor acylcoenzyme A:cholesterol O-acyltransferase inhibitors cholesterol acyltransferase inhibitor cholesterol acyltransferase inhibitors cholesterol ester synthase inhibitor cholesterol ester synthase inhibitors cholesterol ester synthetase inhibitor cholesterol ester synthetase inhibitors cholesteryl ester synthetase inhibitor cholesteryl ester synthetase inhibitors sterol O-acyltransferase (EC 2.3.1.26) inhibitor sterol O-acyltransferase (EC 2.3.1.26) inhibitors sterol O-acyltransferase inhibitor sterol O-acyltransferase inhibitors sterol-ester synthase inhibitor sterol-ester synthase inhibitors sterol-ester synthetase inhibitor sterol-ester synthetase inhibitors EC 2.3.1.26 (sterol O-acyltransferase) inhibitor acyl-CoA:cholesterol acyltransferase 2 inhibitor ACAT-2 inhibitor ACAT-2 inhibitors acyl-CoA:cholesterol acyltransferase 2 inhibitors acyl-CoA:cholesterol acyltransferase 2 inhibitor EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitor 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitors 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitor 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitors 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase inhibitor 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase inhibitors EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitors EC 3.1.4.11 inhibitor EC 3.1.4.11 inhibitors PI-PLC inhibitor PI-PLC inhibitors monophosphatidylinositol phosphodiesterase inhibitor monophosphatidylinositol phosphodiesterase inhibitors phosphatidylinositol phospholipase C inhibitor phosphatidylinositol phospholipase C inhibitors phosphatidylinositol-specific phospholipase C inhibitor phosphatidylinositol-specific phospholipase C inhibitors phosphoinositidase C inhibitor phosphoinositidase C inhibitors phosphoinositide phospholipase C (EC 3.1.4.11) inhibitor phosphoinositide phospholipase C (EC 3.1.4.11) inhibitors phosphoinositide phospholipase C inhibitor phosphoinositide phospholipase C inhibitors triphosphoinositide phosphodiesterase inhibitor triphosphoinositide phosphodiesterase inhibitors EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor cosmetic cosmetic component cosmetics cosmetic poison poisonous agent poisonous agents poisonous substance poisonous substances poisons toxic agent toxic agents toxic substance toxic substances poison antimitotic antimitotics mitosis inhibitor mitosis inhibitors mitotic inhibitor mitotic inhibitors antimitotic antimycobacterial drug antimycobacterial agent antimycobacterial agents antimycobacterial drugs antimycobacterials antimycobacterium antimycobacterial drug antiplasmodial drug antiplasmodial agent antiplasmodial agents antiplasmodial drugs antiplasmodium agent antiplasmodium agents antiplasmodium drug antiplasmodium drugs antiplasmodial drug EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor 1,2-diacylglycerol acyltransferase inhibitor 1,2-diacylglycerol acyltransferase inhibitors DGAT inhibitor DGAT inhibitors EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitors EC 2.3.1.20 inhibitor EC 2.3.1.20 inhibitors acyl-CoA:1,2-diacylglycerol O-acyltransferase inhibitor acyl-CoA:1,2-diacylglycerol O-acyltransferase inhibitors diacylglycerol O-acyltransferase (EC 2.3.1.20) inhibitor diacylglycerol O-acyltransferase (EC 2.3.1.20) inhibitors diacylglycerol O-acyltransferase inhibitor diacylglycerol O-acyltransferase inhibitors diacylglycerol acyltransferase inhibitor diacylglycerol acyltransferase inhibitors diglyceride O-acyltransferase inhibitor diglyceride O-acyltransferase inhibitors diglyceride acyltransferase inhibitor diglyceride acyltransferase inhibitors palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase inhibitor palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase inhibitors EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor EC 6.5.1.1 [DNA ligase (ATP)] inhibitor DNA joinase inhibitor DNA joinase inhibitors DNA ligase (ATP) (EC 6.5.1.1) inhibitor DNA ligase (ATP) (EC 6.5.1.1) inhibitors DNA ligase (ATP) inhibitor DNA ligase inhibitor DNA ligase inhibitors DNA repair enzyme inhibitor DNA repair enzyme inhibitors DNA-joining enzyme inhibitor DNA-joining enzyme inhibitors EC 6.5.1.1 (DNA ligase (ATP)) inhibitor EC 6.5.1.1 (DNA ligase (ATP)) inhibitors EC 6.5.1.1 [DNA ligase (ATP)] inhibitors EC 6.5.1.1 inhibitor EC 6.5.1.1 inhibitors deoxyribonucleate ligase inhibitor deoxyribonucleate ligase inhibitors deoxyribonucleic acid joinase inhibitor deoxyribonucleic acid joinase inhibitors deoxyribonucleic acid ligase inhibitor deoxyribonucleic acid ligase inhibitors deoxyribonucleic acid repair enzyme inhibitor deoxyribonucleic acid repair enzyme inhibitors deoxyribonucleic acid-joining enzyme inhibitor deoxyribonucleic acid-joining enzyme inhibitors deoxyribonucleic joinase inhibitor deoxyribonucleic joinase inhibitors deoxyribonucleic ligase inhibitor deoxyribonucleic ligase inhibitors deoxyribonucleic repair enzyme inhibitor deoxyribonucleic repair enzyme inhibitors deoxyribonucleic-joining enzyme inhibitor deoxyribonucleic-joining enzyme inhibitors polydeoxyribonucleotide synthase (ATP) inhibitor sealase inhibitor sealase inhibitors EC 6.5.1.1 [DNA ligase (ATP)] inhibitor EC 3.4.21.37 (leukocyte elastase) inhibitor EC 3.4.21.37 (leukocyte elastase) inhibitors EC 3.4.21.37 inhibitor EC 3.4.21.37 inhibitors elastase inhibitor elastase inhibitors elaszym inhibitor elaszym inhibitors granulocyte elastase inhibitor granulocyte elastase inhibitors leukocyte elastase (EC 3.4.21.37) inhibitor leukocyte elastase (EC 3.4.21.37) inhibitors leukocyte elastase inhibitor lysosomal elastase inhibitor lysosomal elastase inhibitors neutrophil elastase inhibitor neutrophil elastase inhibitors polymorphonuclear leukocyte elastase inhibitor polymorphonuclear leukocyte elastase inhibitors serine elastase inhibitor serine elastase inhibitors EC 3.4.21.37 (leukocyte elastase) inhibitor hepatitis C protease inhibitor hepatitis C protease inhibitors hepatitis C protease inhibitor serine protease inhibitor serine protease inhibitors serine proteinase inhibitor serine proteinase inhibitors serine protease inhibitor cathepsin B inhibitor EC 3.4.22.1 inhibitor EC 3.4.22.1 inhibitors cathepsin B inhibitors cathepsin B1 inhibitor cathepsin B1 inhibitors cathepsin II inhibitor cathepsin II inhibitors cathepsin B inhibitor melanin synthesis inhibitor melanin biosynthesis inhibitor melanin biosynthesis inhibitors melanin synthesis inhibitors melanogenesis inhibitor melanogenesis inhibitors melanin synthesis inhibitor EC 3.4.21.1 (chymotrypsin) inhibitor EC 3.4.21.1 (chymotrypsin) inhibitors EC 3.4.21.1 inhibitor EC 3.4.21.1 inhibitors alpha-chymar inhibitor alpha-chymar inhibitors alpha-chymar ophth inhibitor alpha-chymar ophth inhibitors alpha-chymotrypsin inhibitor alpha-chymotrypsin inhibitors avazyme inhibitor avazyme inhibitors chymar inhibitor chymar inhibitors chymotest inhibitor chymotest inhibitors chymotrypsin (EC 3.4.21.1) inhibitor chymotrypsin (EC 3.4.21.1) inhibitors chymotrypsin inhibitor chymotrypsin inhibitors chymotrypsins A and B inhibitor chymotrypsins A and B inhibitors chymotrypsins A inhibitor chymotrypsins A inhibitors chymotrypsins B inhibitor chymotrypsins B inhibitors enzeon inhibitor enzeon inhibitors quimar inhibitor quimar inhibitors quimotrase inhibitor quimotrase inhibitors EC 3.4.21.1 (chymotrypsin) inhibitor anti-HIV agent anti-AIDS agent anti-AIDS agents anti-HIV agents anti-HIV agent anti-HIV-1 agent anti-HIV-1 agents anti-HTLV-III agent anti-HTLV-III agents anti-LAV agent anti-LAV agents anti-HIV-1 agent anti-HIV-2 agent anti-HIV-2 agents anti-HIV-2 agent anti-HBV agent anti-HBV agents anti-hepatitis B virus agent anti-hepatitis B virus agents anti-HBV agent anti-HSV agent anti-HHV agent anti-HHV agents anti-HSV agents anti-herpes simplex virus agent anti-herpes simplex virus agents anti-human herpes virus agent anti-human herpes virus agents anti-HSV agent anti-HSV-1 agent anti-HHV-1 agent anti-HHV-1 agents anti-HHV-I agent anti-HHV-I agents anti-HSV-1 agents anti-HSV-I agent anti-HSV-I agents anti-human herpes virus-1 agent anti-human herpes virus-1 agents anti-human herpes virus-I agent anti-human herpes virus-I agents anti-HSV-1 agent anti-HSV-2 agent anti-HHV-2 agent anti-HHV-2 agents anti-HHV-II agent anti-HHV-II agents anti-HSV-2 agents anti-HSV-II agent anti-HSV-II agents anti-human herpes virus-2 agent anti-human herpes virus-2 agents anti-human herpes virus-II agent anti-human herpes virus-II agents anti-HSV-2 agent EC 3.2.1.166 (heparanase) inhibitor C1A heparanase inhibitor C1A heparanase inhibitors EC 3.2.1.166 (heparanase) inhibitors HPSE inhibitor HPSE inhibitors Hpa1 heparanase inhibitor Hpa1 heparanase inhibitors Hpa1 inhibitor Hpa1 inhibitors heparan sulfate N-sulfo-D-glucosamine endoglucanase inhibitor heparan sulfate N-sulfo-D-glucosamine endoglucanase inhibitors heparanase (EC 3.2.1.166) inhibitor heparanase (EC 3.2.1.166) inhibitors heparanase 1 inhibitor heparanase 1 inhibitors heparanase inhibitor heparanase inhibitors heparanase-1 inhibitor heparanase-1 inhibitors EC 3.2.1.166 (heparanase) inhibitor EC 3.4.21.39 (chymase) inhibitor EC 3.4.21.39 (chymase) inhibitors EC 3.4.21.39 inhibitor EC 3.4.21.39 inhibitors SK protease inhibitor SK protease inhibitors chymase (EC 3.4.21.39) inhibitor chymase (EC 3.4.21.39) inhibitors chymase inhibitor chymase inhibitors mast cell protease I inhibitor mast cell protease I inhibitors skeletal muscle (SK) protease inhibitor skeletal muscle (SK) protease inhibitors skeletal muscle protease inhibitor skeletal muscle protease inhibitors skin chymotryptic proteinase inhibitor skin chymotryptic proteinase inhibitors EC 3.4.21.39 (chymase) inhibitor EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor 5-LOX inhibitor 5-LOX inhibitors 5-lipoxygenase inhibitor 5-lipoxygenase inhibitors 5delta-lipoxygenase inhibitor 5delta-lipoxygenase inhibitors C-5-lipoxygenase inhibitor C-5-lipoxygenase inhibitors EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitors EC 1.13.11.34 inhibitor EC 1.13.11.34 inhibitors LTA synthase inhibitor LTA synthase inhibitors arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitor arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitors arachidonate 5-lipoxygenase inhibitor arachidonate 5-lipoxygenase inhibitors arachidonic 5-lipoxygenase inhibitor arachidonic 5-lipoxygenase inhibitors arachidonic acid 5-lipoxygenase inhibitor arachidonic acid 5-lipoxygenase inhibitors delta(5)-lipoxygenase inhibitor delta(5)-lipoxygenase inhibitors leukotriene A4 synthase inhibitor leukotriene A4 synthase inhibitors leukotriene-A4 synthase inhibitor leukotriene-A4 synthase inhibitors EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor 12-LOX inhibitor 12-LOX inhibitors 12-lipoxygenase inhibitor 12-lipoxygenase inhibitors 12S-lipoxygenase inhibitor 12S-lipoxygenase inhibitors 5delta-lipoxygenase inhibitor 5delta-lipoxygenase inhibitors C-5-lipoxygenase inhibitor C-5-lipoxygenase inhibitors EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitors EC 1.13.11.31 inhibitor EC 1.13.11.31 inhibitors LTA4 synthase inhibitor LTA4 synthase inhibitors arachidonate 12-lipoxygenase (EC 1.13.11.31) inhibitor arachidonate 12-lipoxygenase (EC 1.13.11.31) inhibitors arachidonate 12-lipoxygenase inhibitor arachidonate 12-lipoxygenase inhibitors delta(12)-lipoxygenase inhibitor delta(12)-lipoxygenase inhibitors leukotriene A4 synthase inhibitor leukotriene A4 synthase inhibitors EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor 15-LOX inhibitor 15-LOX inhibitors 15-lipoxygenase inhibitor 15-lipoxygenase inhibitors EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitors EC 1.13.11.33 inhibitor EC 1.13.11.33 inhibitors arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitor arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitors arachidonate 15-lipoxygenase inhibitor arachidonate 15-lipoxygenase inhibitors arachidonate:oxygen 15-oxidoreductase inhibitor arachidonate:oxygen 15-oxidoreductase inhibitors linoleic acid omega(6)-lipoxygenase inhibitor linoleic acid omega(6)-lipoxygenase inhibitors omega(6) lipoxygenase inhibitor omega(6) lipoxygenase inhibitors EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor EC 3.1.1.3 (triacylglycerol lipase) inhibitor EC 3.1.1.3 (triacylglycerol lipase) inhibitors EC 3.1.1.3 inhibitor EC 3.1.1.3 inhibitors GEH inhibitor GEH inhibitors PPL inhibitor PPL inhibitors Tween hydrolase inhibitor Tween hydrolase inhibitors Tweenase inhibitor Tweenase inhibitors Tweenesterase inhibitor Tweenesterase inhibitors butyrinase inhibitor butyrinase inhibitors cacordase inhibitor cacordase inhibitors capalase L inhibitor capalase L inhibitors glycerol ester hydrolase inhibitor glycerol ester hydrolase inhibitors glycerol-ester hydrolase inhibitor glycerol-ester hydrolase inhibitors heparin releasable hepatic lipase inhibitor heparin releasable hepatic lipase inhibitors hepatic lipase inhibitor hepatic lipase inhibitors hepatic monoacylglycerol acyltransferase inhibitor hepatic monoacylglycerol acyltransferase inhibitors lipase inhibitor lipase inhibitors lipazin inhibitor lipazin inhibitors liver lipase inhibitor liver lipase inhibitors pancreatic lipase inhibitor pancreatic lipase inhibitors pancreatic triacylglycerol lipase inhibitor pancreatic triacylglycerol lipase inhibitors post-heparin plasma protamine-resistant lipase inhibitor post-heparin plasma protamine-resistant lipase inhibitors salt-resistant post-heparin lipase inhibitor salt-resistant post-heparin lipase inhibitors steapsin inhibitor steapsin inhibitors triacetinase inhibitor triacetinase inhibitors triacylglycerol ester hydrolase inhibitor triacylglycerol ester hydrolase inhibitors triacylglycerol lipase (EC 3.1.1.3) inhibitor triacylglycerol lipase (EC 3.1.1.3) inhibitors triacylglycerol lipase inhibitor triacylglycerol lipase inhibitors tributyrase inhibitor tributyrase inhibitors tributyrin esterase inhibitor tributyrin esterase inhibitors tributyrinase inhibitor tributyrinase inhibitors triglyceridase inhibitor triglyceridase inhibitors triglyceride hydrolase inhibitor triglyceride hydrolase inhibitors triglyceride lipase inhibitor triglyceride lipase inhibitors triolein hydrolase inhibitor triolein hydrolase inhibitors tween-hydrolysing esterase inhibitor tween-hydrolyzing esterase inhibitors EC 3.1.1.3 (triacylglycerol lipase) inhibitor anti-asthmatic agent anti-asthmatic agents antiasthmatic agent antiasthmatic agents anti-asthmatic agent EC 4.1.1.19 (arginine decarboxylase) inhibitor ADC inhibitor ADC inhibitors EC 4.1.1.19 (arginine decarboxylase) inhibitors EC 4.1.1.19 inhibitor EC 4.1.1.19 inhibitors L-arginine carboxy-lyase (agmatine-forming) inhibitor L-arginine carboxy-lyase (agmatine-forming) inhibitors L-arginine carboxy-lyase inhibitor L-arginine carboxy-lyase inhibitors SpeA inhibitor SpeA inhibitors arginine decarboxylase (EC 4.1.1.19) inhibitor arginine decarboxylase (EC 4.1.1.19) inhibitors arginine decarboxylase inhibitor arginine decarboxylase inhibitors EC 4.1.1.19 (arginine decarboxylase) inhibitor EC 3.1.3.11 (fructose-bisphosphatase) inhibitor D-fructose 1,6-diphosphatase inhibitor D-fructose 1,6-diphosphatase inhibitors D-fructose-1,6-bisphosphate 1-phosphohydrolase inhibitor D-fructose-1,6-bisphosphate 1-phosphohydrolase inhibitors D-fructose-1,6-bisphosphate phosphatase inhibitor D-fructose-1,6-bisphosphate phosphatase inhibitors EC 3.1.3.11 (fructose-bisphosphatase) inhibitors EC 3.1.3.11 inhibitor EC 3.1.3.11 inhibitors FBPase inhibitor FBPase inhibitors fructose 1,6-bisphosphatase inhibitor fructose 1,6-bisphosphatase inhibitors fructose 1,6-bisphosphate 1-phosphatase inhibitor fructose 1,6-bisphosphate 1-phosphatase inhibitors fructose 1,6-bisphosphate phosphatase inhibitor fructose 1,6-bisphosphate phosphatase inhibitors fructose 1,6-diphosphatase inhibitor fructose 1,6-diphosphatase inhibitors fructose 1,6-diphosphate phosphatase inhibitor fructose 1,6-diphosphate phosphatase inhibitors fructose bisphosphate phosphatase inhibitor fructose bisphosphate phosphatase inhibitors fructose diphosphatase inhibitor fructose diphosphatase inhibitors fructose diphosphate phosphatase inhibitor fructose diphosphate phosphatase inhibitors fructose-bisphosphatase (EC 3.1.3.11) inhibitor fructose-bisphosphatase (EC 3.1.3.11) inhibitors fructose-bisphosphatase inhibitor fructose-bisphosphatase inhibitors hexose bisphosphatase inhibitor hexose bisphosphatase inhibitors hexose diphosphatase inhibitor EC 3.1.3.11 (fructose-bisphosphatase) inhibitor adenosine A1 receptor agonist adenosine A1 receptor agonists adenosine A1 receptor agonist EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor CFA synthase inhibitor CFA synthase inhibitors EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitors EC 2.1.1.79 inhibitor EC 2.1.1.79 inhibitors S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclising) inhibitor S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclising) inhibitors S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing) inhibitor S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing) inhibitors cyclopropane fatty acid synthase inhibitors cyclopropane fatty acid synthetase inhibitor cyclopropane fatty acid synthetase inhibitors cyclopropane synthase inhibitor cyclopropane synthase inhibitors cyclopropane synthetase inhibitor cyclopropane synthetase inhibitors cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) inhibitor cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) inhibitors cyclopropane-fatty-acyl-phospholipid synthase inhibitor cyclopropane-fatty-acyl-phospholipid synthase inhibitors unsaturated-phospholipid methyltransferase inhibitor unsaturated-phospholipid methyltransferase inhibitors EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor DNA adenine methyltransferase inhibitor DNA adenine methyltransferase inhibitors Dam inhibitor Dam inhibitors EC 2.1.1.72 (site-specific DNA-methyltransferase (adenine-specific)) inhibitor EC 2.1.1.72 (site-specific DNA-methyltransferase (adenine-specific)) inhibitors EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitors EC 2.1.1.72 inhibitor EC 2.1.1.72 inhibitors modification methylase inhibitor modification methylase inhibitors restriction-modification system inhibitor restriction-modification system inhibitors site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) inhibitor site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) inhibitors site-specific DNA-methyltransferase (adenine-specific) inhibitor site-specific DNA-methyltransferase (adenine-specific) inhibitors EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor first generation antipsychotic first generation antipsychotic agent first generation antipsychotic agents first generation antipsychotic drug first generation antipsychotic drugs first generation antipsychotics typical antipsychotic typical antipsychotic agent typical antipsychotic agents typical antipsychotic drug typical antipsychotic drugs typical antipsychotics first generation antipsychotic second generation antipsychotic atypical antipsychotic atypical antipsychotic agent atypical antipsychotic agents atypical antipsychotic drug atypical antipsychotic drugs atypical antipsychotics second generation antipsychotic agent second generation antipsychotic agents second generation antipsychotic drug second generation antipsychotic drugs second generation antipsychotics second generation antipsychotic vascular endothelial growth factor receptor antagonist VEGF receptor inhibitor VEGF receptor inhibitors VEGFR inhibitor VEGFR inhibitors vascular endothelial growth factor receptor antagonists vascular endothelial growth factor receptor inhibitor vascular endothelial growth factor receptor inhibitors vascular endothelial growth factor receptor antagonist EC 3.4.21.5 (thrombin) inhibitor E thrombin inhibitor E thrombin inhibitors EC 3.4.21.5 (thrombin) inhibitors EC 3.4.21.5 inhibitor EC 3.4.21.5 inhibitors activated blood-coagulation factor II inhibitor activated blood-coagulation factor II inhibitors beta-thrombin inhibitor beta-thrombin inhibitors blood-coagulation factor IIa inhibitor blood-coagulation factor IIa inhibitors factor IIa inhibitor factor IIa inhibitors fibrinogenase inhibitor fibrinogenase inhibitors gamma-thrombin inhibitor gamma-thrombin inhibitors thrombase inhibitor thrombase inhibitors thrombin (EC 3.4.21.5) inhibitor thrombin (EC 3.4.21.5) inhibitors thrombin inhibitor thrombin inhibitors thrombin-C inhibitor thrombin-C inhibitors thrombofort inhibitor thrombofort inhibitors tropostasin inhibitor tropostasin inhibitors EC 3.4.21.5 (thrombin) inhibitor EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitor (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitors 1,3(1,6)-alpha-D-mannosidase inhibitor 1,3(1,6)-alpha-D-mannosidase inhibitors 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitor 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitors EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitors EC 3.2.1.114 inhibitor EC 3.2.1.114 inhibitors GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase inhibitor GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase inhibitors Golgi alpha-mannosidase II inhibitor Golgi alpha-mannosidase II inhibitors ManII inhibitor ManII inhibitors alpha-D-mannosidase II inhibitor alpha-D-mannosidase II inhibitors alpha-mannosidase II inhibitor alpha-mannosidase II inhibitors alpha1-3,6-mannosidase inhibitor alpha1-3,6-mannosidase inhibitors exo-1,3-1,6-alpha-mannosidase inhibitor exo-1,3-1,6-alpha-mannosidase inhibitors golgi alpha-mannosidase II inhibitor golgi alpha-mannosidase II inhibitors mannosidase II inhibitor mannosidase II inhibitors mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114) inhibitor mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114) inhibitors mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase inhibitor mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase inhibitors EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor LRH-1 agonist LRH-1 agonists NR5A2 agonist NR5A2 agonists liver receptor homologue-1 agonist liver receptor homologue-1 agonists nuclear receptor subfamily 5 group A member 2 agonist nuclear receptor subfamily 5 group A member 2 agonists LRH-1 agonist food preservative food preservatives food preservative antimicrobial food preservative antimicrobial food preservatives antimicrobial preservative antimicrobial preservatives antimicrobial food preservative GABA antagonist GABA antagonists gamma-aminobutyric acid receptor antagonist gamma-aminobutyric acid receptor antagonists GABA antagonist antacid antacids antacid erythropeotin receptor agonist erythropeotin receptor agonist erythropoiesis-stimulating agent erythropoiesis-stimulating agents erythropeotin receptor agonist prostaglandin receptor agonist prostaglandin receptor agonists prostaglandin receptor agonist CFTR potentiator CFTR potentiators cystic fibrosis transmembrane conductance regulator potentiator cystic fibrosis transmembrane conductance regulator potentiators CFTR potentiator SMO receptor antagonist SMO receptor antagonists smoothened antagonist smoothened antagonists smoothened receptor antagonist smoothened receptor antagonists SMO receptor antagonist antidyskinesia agent antidyskinesia agents antidyskinesia drug antidyskinesia drugs antidyskinetic agent antidyskinetic agents antidyskinetic drug antidyskinetic drugs antidyskinesia agent nootropic agent cognitive enhancer cognitive enhancers intelligence enhancer intelligence enhancers memory enhancer memory enhancers neuro enhancer neuro enhancers nootropic nootropic agents nootropic drug nootropic drugs nootropics smart drug smart drugs nootropic agent ophthalmology drug ophthalmic ophthalmic agent ophthalmic agents ophthalmics ophthalmological ophthalmologicals ophthalmology agent ophthalmology agents ophthalmology drugs ophthalmology drug radiation protective agent radiation mitigation agent radiation mitigation agents radiation protective agents radiation protective drug radiation protective drugs radioprotective agent radioprotective agents radioprotector radioprotectors radiation protective agent sympatholytic agent sympatholytic sympatholytic agents sympatholytic drug sympatholytic drugs sympatholytics sympatholytic agent tocolytic agent anti-contraction drug anti-contraction drugs anti-contraction medication anti-contraction medications labour repressant labour repressants tocolytic tocolytic agents tocolytic drug tocolytic drugs tocolytics tocolytic agent cannabinoid receptor agonist cannabinoid receptor agonists cannabinoid receptor agonist anti-inflammatory agent anti-inflammatory agents antiinflammatory agent antiinflammatory agents anti-inflammatory agent insect sterilant insect chemosterilant insect chemosterilants insect sterilants insect sterilant ryanodine receptor agonist RyR activator RyR activators RyR agonist RyR agonists RyRs activator RyRs agonist ryanodine receptor activator ryanodine receptor activators ryanodine receptor agonist colorimetric reagent color reagent color reagents colorimetric reagents colour reagent colour reagents colorimetric reagent NMR shift reagent NMR shift reagents lanthanide shift reagent lanthanide shift reagents nuclear magnetic resonance shift reagent nuclear magnetic resonance shift reagents NMR shift reagent EC 3.4.24.3 (microbial collagenase) inhibitor Achromobacter iophagus collagenase inhibitor Achromobacter iophagus collagenase inhibitors Clostridium histolyticum collagenase inhibitor Clostridium histolyticum collagenase inhibitors Clostridium histolyticum proteinase A inhibitor Clostridium histolyticum proteinase A inhibitors EC 3.4.24.3 (microbial collagenase) inhibitors EC 3.4.24.3 inhibitor EC 3.4.24.3 inhibitors MMP-1 inhibitor MMP-1 inhibitors MMP-8 inhibitor MMP-8 inhibitors aspergillopeptidase C inhibitor aspergillopeptidase C inhibitors azocollase inhibitor azocollase inhibitors clostridiopeptidase A inhibitor clostridiopeptidase A inhibitors clostridiopeptidase I inhibitor clostridiopeptidase I inhibitors clostridiopeptidase II inhibitor clostridiopeptidase II inhibitors collagen peptidase inhibitor collagen peptidase inhibitors collagen protease inhibitor collagen protease inhibitors collagenase A inhibitor collagenase A inhibitors collagenase I inhibitor collagenase I inhibitors collagenase MMP-1 inhibitor collagenase MMP-1 inhibitors collagenase inhibitor collagenase inhibitors interstitial collagenase inhibitor interstitial collagenase inhibitors kollaza inhibitor kollaza inhibitors matrix metalloproteinase-1 inhibitor matrix metalloproteinase-1 inhibitors matrix metalloproteinase-18 inhibitor matrix metalloproteinase-18 inhibitors matrix metalloproteinase-8 inhibitor matrix metalloproteinase-8 inhibitors metallocollagenase inhibitor metallocollagenase inhibitors metalloproteinase-1 inhibitor metalloproteinase-1 inhibitors microbial collagenase (EC 3.4.24.3) inhibitor microbial collagenase (EC 3.4.24.3) inhibitors microbial collagenase inhibitor microbial collagenase inhibitors nucleolysin inhibitor nucleolysin inhibitors soycollagestin inhibitor soycollagestin inhibitors EC 3.4.24.3 (microbial collagenase) inhibitor gap junctional intercellular communication inhibitor gap junctional intercellular communication inhibitors gap junctional intercellular communication inhibitor retinoic acid receptor agonist retinoic acid receptor agonists retinoic acid receptor agonist AP-1 antagonist AP-1 antagonists activator protein-1 antagonist activator protein-1 antagonists AP-1 antagonist provitamin A provitamin As provitamin A EC 3.2.1.45 (glucosylceramidase) inhibitor D-glucosyl-N-acylsphingosine glucohydrolase inhibitor D-glucosyl-N-acylsphingosine glucohydrolase inhibitors EC 3.2.1.45 (glucosylceramidase) inhibitors EC 3.2.1.45 inhibitor EC 3.2.1.45 inhibitors GlcCer-beta-glucosidase inhibitor GlcCer-beta-glucosidase inhibitors acid beta-glucosidase inhibitor acid beta-glucosidase inhibitors acid-beta-glucosidase inhibitor acid-beta-glucosidase inhibitors beta-D-glucocerebrosidase inhibitor beta-D-glucocerebrosidase inhibitors beta-glucosylceramidase inhibitor beta-glucosylceramidase inhibitors ceramide glucosidase inhibitor ceramide glucosidase inhibitors glucocerebrosidase inhibitor glucocerebrosidase inhibitors glucosphingosine glucosylhydrolase inhibitor glucosphingosine glucosylhydrolase inhibitors glucosylceramidase (EC 3.2.1.45) inhibitor glucosylceramidase (EC 3.2.1.45) inhibitors glucosylceramidase inhibitor glucosylceramidase inhibitors glucosylcerebrosidase inhibitor glucosylcerebrosidase inhibitors glucosylsphingosine beta-D-glucosidase inhibitor glucosylsphingosine beta-D-glucosidase inhibitors glucosylsphingosine beta-glucosidase inhibitor glucosylsphingosine beta-glucosidase inhibitors psychosine hydrolase inhibitor psychosine hydrolase inhibitors EC 3.2.1.45 (glucosylceramidase) inhibitor EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitors EC 3.2.1.48 inhibitor EC 3.2.1.48 inhibitors intestinal sucrase inhibitor intestinal sucrase inhibitors sucrase (invertase) inhibitor sucrase (invertase) inhibitors sucrase inhibitor sucrase inhibitors sucrase-isomaltase inhibitor sucrase-isomaltase inhibitors sucrose alpha-glucohydrolase inhibitor sucrose alpha-glucohydrolase inhibitors sucrose alpha-glucosidase (EC 3.2.1.48) inhibitor sucrose alpha-glucosidase (EC 3.2.1.48) inhibitors sucrose alpha-glucosidase inhibitor sucrose alpha-glucosidase inhibitors sucrose-alpha-D-glucohydrolase inhibitor sucrose-alpha-D-glucohydrolase inhibitors EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitors EC 3.2.1.10 inhibitor EC 3.2.1.10 inhibitors alpha-limit dextrinase inhibitor alpha-limit dextrinase inhibitors dextrin 6-glucanohydrolase inhibitor dextrin 6-glucanohydrolase inhibitors dextrin 6alpha-glucanohydrolase inhibitor dextrin 6alpha-glucanohydrolase inhibitors exo-oligo-1,6-glucosidase inhibitor exo-oligo-1,6-glucosidase inhibitors isomaltase inhibitor isomaltase inhibitors oligo-1,6-glucosidase (EC 3.2.1.10) inhibitor oligo-1,6-glucosidase (EC 3.2.1.10) inhibitors oligo-1,6-glucosidase inhibitor oligo-1,6-glucosidase inhibitors oligosaccharide alpha-1,6-glucohydrolase inhibitor oligosaccharide alpha-1,6-glucohydrolase inhibitors sucrase-isomaltase inhibitor sucrase-isomaltase inhibitors EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor EC 3.2.1.20 (alpha-glucosidase) inhibitor EC 3.2.1.20 (alpha-glucosidase) inhibitors EC 3.2.1.20 inhibitor EC 3.2.1.20 inhibitors alpha-1,4-glucosidase inhibitor alpha-1,4-glucosidase inhibitors alpha-D-glucosidase inhibitor alpha-D-glucosidase inhibitors alpha-glucopyranosidase inhibitor alpha-glucopyranosidase inhibitors alpha-glucosidase (EC 3.2.1.20) inhibitor alpha-glucosidase (EC 3.2.1.20) inhibitors alpha-glucosidase inhibitor alpha-glucosidase inhibitors alpha-glucoside hydrolase inhibitor alpha-glucoside hydrolase inhibitors glucoinvertase inhibitor glucoinvertase inhibitors glucosidoinvertase inhibitor glucosidoinvertase inhibitors glucosidosucrase inhibitor glucosidosucrase inhibitors maltase inhibitor maltase inhibitors maltase-glucoamylase inhibitor maltase-glucoamylase inhibitors EC 3.2.1.20 (alpha-glucosidase) inhibitor EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitors EC 2.5.1.59 inhibitor EC 2.5.1.59 inhibitors GGTase I inhibitor GGTase I inhibitors geranylgeranyl-diphosphate:protein-cysteine geranyltransferase inhibitor geranylgeranyl-diphosphate:protein-cysteine geranyltransferase inhibitors geranylgeranyltransferase type I inhibitor geranylgeranyltransferase type I inhibitors protein geranylgeranyltransferase type I (EC 2.5.1.59) inhibitor protein geranylgeranyltransferase type I (EC 2.5.1.59) inhibitors protein geranylgeranyltransferase type I inhibitor protein geranylgeranyltransferase type I inhibitors EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor HIV-1 integrase inhibitor HIV-1 integrase inhibitor metformin 1,1-dimethylbiguanide LA 6023 LA-6023 N(1),N(1)-dimethylbiguanide N,N-dimethylbiguanide N,N-dimethyldiguanide N,N-dimethylguanylguanidine N,N-dimethylimidodicarbonimidic diamide N,N-dimethyltriimidodicarbonic diamide dimethylbiguanide dimethyldiguanide metformin metformina metformine metforminum metformin mTOR inhibitor mTOR inhibitors mammalian target of rapamycin inhibitor mammalian target of rapamycin inhibitors mTOR inhibitor apoptosis inhibitor Type I cell-death inhibitor Type I cell-death inhibitors Type I programmed cell-death inhibitor Type I programmed cell-death inhibitors apoptosis inhibitors apoptosis inhibitor apoptosis inducer Type I cell-death inducer Type I cell-death inducers Type I programmed cell-death inducer Type I programmed cell-death inducers apoptosis inducers apoptosis inducer glutathione depleting agent glutathione depleting agents glutathione depletion agent glutathione depletion agents glutathione depletor glutathione depletors glutathione depleting agent EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor (S)-dihydroorotate:fumarate oxidoreductase inhibitor (S)-dihydroorotate:fumarate oxidoreductase inhibitors DHODH inhibitor DHODH inhibitors EC 1.3.3.1 inhibitor EC 1.3.3.1 inhibitors EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitor EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitors EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitors EC 1.3.98.1 inhibitor EC 1.3.98.1 inhibitors dihydroorotate dehydrogenase inhibitor dihydroorotate dehydrogenase inhibitors dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitor dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitors dihydroorotate oxidase (fumarate) inhibitor dihydroorotate oxidase (fumarate) inhibitors EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor pyrimidine synthesis inhibitor pyrimidine synthesis inhibitors pyrimidine synthesis inhibitor guanylate cyclase 2C agonist GC-C agonist GC-C agonists guanylate cyclase 2C agonists guanylate cyclase 2C agonist bradykinin receptor antagonist bradykinin receptor antagonists bradykinin receptor antagonist P2Y12 receptor antagonist ADP receptor subtype P2Y12 antagonist ADP receptor subtype P2Y12 antagonists P2Y12 receptor antagonists purinergic receptor subtype P2Y12 antagonist purinergic receptor subtype P2Y12 antagonists P2Y12 receptor antagonist EC 3.4.21.6 (coagulation factor Xa) inhibitor EC 3.4.21.6 (coagulation factor Xa) inhibitors EC 3.4.21.6 inhibitor EC 3.4.21.6 inhibitors Stuart factor inhibitor Stuart factor inhibitors activated Stuart-Prower factor inhibitor activated Stuart-Prower factor inhibitors activated blood-coagulation factor X inhibitor activated blood-coagulation factor X inhibitors activated factor X inhibitor activated factor X inhibitors autoprothrombin C inhibitor autoprothrombin C inhibitors coagulation factor Xa (EC 3.4.21.6) inhibitor coagulation factor Xa (EC 3.4.21.6) inhibitors coagulation factor Xa inhibitor coagulation factor Xa inhibitors factor Xa inhibitor factor Xa inhibitors plasma thromboplastin inhibitor plasma thromboplastin inhibitors prothrombase inhibitor prothrombase inhibitors prothrombinase inhibitor prothrombinase inhibitors thrombokinase inhibitor thrombokinase inhibitors thromboplastin inhibitor thromboplastin inhibitors EC 3.4.21.6 (coagulation factor Xa) inhibitor EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor DPP IV/CD26 inhibitor DPP IV/CD26 inhibitors DPP-4 inhibitor DPP-4 inhibitors EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitors EC 3.4.14.5 inhibitor EC 3.4.14.5 inhibitors Gly-Pro naphthylamidase inhibitor Gly-Pro naphthylamidase inhibitors T cell triggering molecule Tp103 inhibitor T cell triggering molecule Tp103 inhibitors X-PDAP inhibitor X-PDAP inhibitors X-prolyl dipeptidyl aminopeptidase inhibitor X-prolyl dipeptidyl aminopeptidase inhibitors Xaa-Pro-dipeptidyl-aminopeptidase inhibitor Xaa-Pro-dipeptidyl-aminopeptidase inhibitors amino acyl-prolyl dipeptidyl aminopeptidase inhibitor amino acyl-prolyl dipeptidyl aminopeptidase inhibitors dipeptidyl aminopeptidase IV inhibitor dipeptidyl aminopeptidase IV inhibitors dipeptidyl peptidase IV inhibitor dipeptidyl peptidase IV inhibitors dipeptidyl peptidase-4 inhibitors dipeptidyl-aminopeptidase IV inhibitor dipeptidyl-aminopeptidase IV inhibitors dipeptidyl-peptidase IV (EC 3.4.14.5) inhibitor dipeptidyl-peptidase IV (EC 3.4.14.5) inhibitors dipeptidyl-peptidase IV inhibitor dipeptidyl-peptidase IV inhibitors dipeptidyl-peptide hydrolase inhibitor dipeptidyl-peptide hydrolase inhibitors glycoprotein GP110 inhibitor glycoprotein GP110 inhibitors glycylproline aminopeptidase inhibitor glycylproline aminopeptidase inhibitors glycylprolyl aminopeptidase inhibitor glycylprolyl aminopeptidase inhibitors glycylprolyl dipeptidylaminopeptidase inhibitor glycylprolyl dipeptidylaminopeptidase inhibitors leukocyte antigen CD26 inhibitor leukocyte antigen CD26 inhibitors lymphocyte antigen CD26 inhibitor lymphocyte antigen CD26 inhibitors pep X inhibitor pep X inhibitors postproline dipeptidyl aminopeptidase IV inhibitor postproline dipeptidyl aminopeptidase IV inhibitors EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor 17-alpha-hydroxylase/C17,20-lyase inhibitor 17-alpha-hydroxylase/C17,20-lyase inhibitors 17alpha-hydroxylase-C17,20 lyase inhibitor 17alpha-hydroxylase-C17,20 lyase inhibitors CYP17 inhibitor CYP17 inhibitors CYP17A1 inhibitor CYP17A1 inhibitors EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitors EC 1.14.99.9 inhibitor EC 1.14.99.9 inhibitors cytochrome P-45017alpha inhibitor cytochrome P-45017alpha inhibitors cytochrome P450 (P-45017alpha,lyase) inhibitor cytochrome P450 (P-45017alpha,lyase) inhibitors cytochrome P450 17-alpha-hydroxylase/C17,20-lyase inhibitor cytochrome P450 17-alpha-hydroxylase/C17,20-lyase inhibitors cytochrome p450 XVIIA1 inhibitor cytochrome p450 XVIIA1 inhibitors steroid 17alpha-hydroxylase inhibitor steroid 17alpha-hydroxylase inhibitors steroid 17alpha-monooxygenase (EC 1.14.99.9) inhibitor steroid 17alpha-monooxygenase (EC 1.14.99.9) inhibitors steroid 17alpha-monooxygenase inhibitor steroid 17alpha-monooxygenase inhibitors steroid 17alphahydroxylase/17,20 lyase inhibitor steroid 17alphahydroxylase/17,20 lyase inhibitors steroid,NADPH--hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating) inhibitor steroid,NADPH--hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating) inhibitors EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor phosphodiesterase IV inhibitor PDE4 inhibitor PDE4 inhibitors phosphodiesterase 4 inhibitor phosphodiesterase 4 inhibitors phosphodiesterase IV inhibitors type 4 phosphodiesterase inhibitor type 4 phosphodiesterase inhibitors phosphodiesterase IV inhibitor midazolam 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine Buccolam Dormicum mezolam midazolam midazolamum midazolam progesterone receptor agonist PR agonist PR agonists progesterone receptor agonists progesterone receptor agonist EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor ACC inhibitor ACC inhibitors ACCase inhibitor ACCase inhibitors EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitors EC 6.4.1.2 inhibitor EC 6.4.1.2 inhibitors acetyl coenzyme A carboxylase inhibitor acetyl coenzyme A carboxylase inhibitors acetyl-CoA carboxylase (EC 6.4.1.2) inhibitor acetyl-CoA carboxylase (EC 6.4.1.2) inhibitors acetyl-CoA carboxylase inhibitor acetyl-CoA carboxylase inhibitors acetyl-CoA:carbon-dioxide ligase (ADP-forming) inhibitor acetyl-CoA:carbon-dioxide ligase (ADP-forming) inhibitors EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor cell dedifferentiation agent cell dedifferentiation agents cell dedifferentiation agent adenosine A3 receptor antagonist adenosine A3 receptor antagonistS adenosine A3 receptor antagonist topoisomerase inhibitor topoisomerase inhibitors topoisomerase inhibitor actin polymerisation inhibitor actin polymerisation inhibitors actin polymerization inhibitor actin polymerization inhibitors inhibitor of actin polymerization inhibitors of actin polymerization actin polymerisation inhibitor Aurora kinase inhibitor Aurora kinase inhibitors Aurora kinase inhibitor capsaicin receptor antagonist TRPV1 antagonist TRPV1 antagonists TrpV1 antagonist TrpV1 antagonists capsaicin antagonist capsaicin antagonists capsaicin receptor antagonists transient receptor potential cation channel subfamily V member 1 antagonist transient receptor potential cation channel subfamily V member 1 antagonists vanilloid receptor 1 antagonist vanilloid receptor 1 antagonists capsaicin receptor antagonist PPAR modulator PPAR modulators peroxisome proliferator-activated receptor modulator peroxisome proliferator-activated receptor modulators PPAR modulator PPARalpha agonist PPAR-alpha agonist PPAR-alpha agonists PPARalpha agonist PPARalpha agonists peroxisome proliferator-activated receptor-alpha agonist peroxisome proliferator-activated receptor-alpha agonists PPARalpha agonist EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitor 3-phosphoglyceraldehyde dehydrogenase inhibitor 3-phosphoglyceraldehyde dehydrogenase inhibitors D-glyceraldehyde-3-phosphate:NAD(+) oxidoreductase (phosphorylating) inhibitor D-glyceraldehyde-3-phosphate:NAD(+) oxidoreductase (phosphorylating) inhibitors EC 1.2.1.12 (glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)) inhibitor EC 1.2.1.12 (glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)) inhibitors EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitors EC 1.2.1.12 inhibitor EC 1.2.1.12 inhibitors GAPDH inhibitor GAPDH inhibitors NAD-dependent glyceraldehyde phosphate dehydrogenase inhibitor NAD-dependent glyceraldehyde phosphate dehydrogenase inhibitors NADH-glyceraldehyde phosphate dehydrogenase inhibitor NADH-glyceraldehyde phosphate dehydrogenase inhibitors dehydrogenase, glyceraldehyde phosphate inhibitor dehydrogenase, glyceraldehyde phosphate inhibitors glyceraldehyde phosphate dehydrogenase (NAD) inhibitor glyceraldehyde phosphate dehydrogenase (NAD) inhibitors glyceraldehyde-3-P-dehydrogenase inhibitor glyceraldehyde-3-P-dehydrogenase inhibitors glyceraldehyde-3-phosphate dehydrogenase (NAD) inhibitor glyceraldehyde-3-phosphate dehydrogenase (NAD) inhibitors glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) inhibitor glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) inhibitors glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) inhibitor glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) inhibitors glyceraldehyde-3-phosphate dehydrogenase inhibitor glyceraldehyde-3-phosphate dehydrogenase inhibitors phosphoglyceraldehyde dehydrogenase inhibitor phosphoglyceraldehyde dehydrogenase inhibitors triosephosphate dehydrogenase inhibitor triosephosphate dehydrogenase inhibitors EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitor cathepsin L (EC 3.4.22.15) inhibitor Aldrichina grahami cysteine proteinase inhibitor Aldrichina grahami cysteine proteinase inhibitors EC 3.4.22.15 inhibitor EC 3.4.22.15 inhibitors cathepsin L (EC 3.4.22.15) inhibitor cathepsin L (EC 3.4.22.15) inhibitors cathepsin L inhibitor cathepsin L inhibitors cathepsin L1 inhibitor cathepsin L1 inhibitors cathepsin L (EC 3.4.22.15) inhibitor EC 3.4.22.2 (papain) inhibitor EC 3.4.22.2 (papain) inhibitor EC 3.4.22.2 inhibitor EC 3.4.22.2 inhibitors papain (EC 3.4.22.2) inhibitor papain (EC 3.4.22.2) inhibitors papain inhibitor papain inhibitors papaine inhibitor papaine inhibitors papaya peptidase I inhibitor papaya peptidase I inhibitors papayotin inhibitor papayotin inhibitors summetrin inhibitor summetrin inhibitors velardon inhibitor velardon inhibitors EC 3.4.22.2 (papain) inhibitor antileishmanial agent antileishmanial agents antileishmanial drug antileishmanial drugs antileishmanial agent reactive oxygen species generator ROS generator ROS generators reactive oxygen species generators reactive oxygen species generator G-protein-coupled receptor agonist G-protein-coupled receptor agonists GPCR agonist GPCR agonists G-protein-coupled receptor agonist AMPA receptor antagonist AMPA receptor antagonists alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists AMPA receptor antagonist progesterone receptor modulator progesterone receptor modulators progesterone receptor modulator orphan drug orphan drugs orphan drug carbamylphosphate synthetase I activator carbamylphosphate synthetase I activators carbamylphosphate synthetase I activator HIV-1 maturation inhibitor HIV-1 maturation inhibitors HIV-1 maturation inhibitor H1-receptor agonist H1-receptor agonists histamine H1-receptor agonist histamine H1-receptor agonists H1-receptor agonist EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor ASMT inhibitor ASMT inhibitors EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitors EC 2.1.1.4 inhibitor EC 2.1.1.4 inhibitors N-acetylserotonin O-methyltransferase inhibitor N-acetylserotonin O-methyltransferase inhibitors N-acetylserotonin methyltransferase inhibitor N-acetylserotonin methyltransferase inhibitors S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase inhibitor S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase inhibitors acetylserotonin O-methyltransferase (EC 2.1.1.4) inhibitor acetylserotonin O-methyltransferase (EC 2.1.1.4) inhibitors acetylserotonin O-methyltransferase inhibitor acetylserotonin O-methyltransferase inhibitors acetylserotonin methyltransferase inhibitor acetylserotonin methyltransferase inhibitors hydroxyindole O-methyltransferase inhibitor hydroxyindole O-methyltransferase inhibitors hydroxyindole methyltransferase inhibitor hydroxyindole methyltransferase inhibitors EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor Sir2 inhibitor Sir2 inhibitors Sir2 inhibitor glucagon-like peptide-1 receptor agonist GLP-1 receptor agonist GLP-1 receptor agonists glucagon-like peptide-1 receptor agonists glucagon-like peptide-1 receptor agonist prohormone prohormones prohormone adenosine receptor antagonist adenosine receptor antagonists adenosine receptor antagonist EC 2.* (transferase) inhibitor EC 2 inhibitor EC 2 inhibitors EC 2.* (transferase) inhibitors EC 2.* inhibitor EC 2.* inhibitors transferase inhibitor transferase inhibitors EC 2.* (transferase) inhibitor autoinducer autoinducers autoinducer EC 2.3.1.85 (fatty acid synthase) inhibitor (FAS) inhibitors EC 2.3.1.85 (fatty acid synthase) inhibitors EC 2.3.1.85 inhibitor EC 2.3.1.85 inhibitors acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitor acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitors fatty acid synthase (EC 2.3.1.85) inhibitor fatty acid synthase (EC 2.3.1.85) inhibitors fatty acid synthase inhibitor fatty acid synthase inhibitors EC 2.3.1.85 (fatty acid synthase) inhibitor EC 3.5.1.23 (ceramidase) inhibitor AC inhibitor AC inhibitors EC 3.5.1.23 (ceramidase) inhibitors EC 3.5.1.23 inhibitor EC 3.5.1.23 inhibitors N-acylsphingosine amidohydrolase inhibitor N-acylsphingosine amidohydrolase inhibitors acid ceramidase inhibitor acid ceramidase inhibitors acylsphingosine deacylase inhibitor acylsphingosine deacylase inhibitors ceramidase (EC 3.5.1.23) inhibitor ceramidase (EC 3.5.1.23) inhibitors ceramidase inhibitor ceramidase inhibitors glycosphingolipid ceramide deacylase inhibitor glycosphingolipid ceramide deacylase inhibitors EC 3.5.1.23 (ceramidase) inhibitor PPARgamma agonist PPAR-gamma agonist PPAR-gamma agonists PPARgamma agonist PPARgamma agonists peroxisome proliferator-activated receptor-gamma agonist peroxisome proliferator-activated receptor-gamma agonists PPARgamma agonist insect repellent insect repellents insect repellent EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor 3',5'-cyclic-GMP 5'-nucleotidohydrolase inhibitor 3',5'-cyclic-GMP 5'-nucleotidohydrolase inhibitors 3',5'-cyclic-GMP phosphodiesterase (EC 3.1.4.35) inhibitor 3',5'-cyclic-GMP phosphodiesterase (EC 3.1.4.35) inhibitors EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitors EC 3.1.4.35 inhibitor EC 3.1.4.35 inhibitors PDE5 inhibitor PDE5 inhibitors cGMP phosphodiesterase inhibitor cGMP phosphodiesterase inhibitors cGMP-PDE inhibitor cGMP-PDE inhibitors cyclic 3',5'-GMP phosphodiesterase inhibitor cyclic 3',5'-GMP phosphodiesterase inhibitors cyclic GMP phosphodiesterase inhibitor cyclic GMP phosphodiesterase inhibitors cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitor cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors cyclic guanosine 3',5'-phosphate phosphodiesterase inhibitor cyclic guanosine 3',5'-phosphate phosphodiesterase inhibitors guanosine cyclic 3',5'-phosphate phosphodiesterase inhibitor guanosine cyclic 3',5'-phosphate phosphodiesterase inhibitors phosphodiesterase 5 inhibitor phosphodiesterase 5 inhibitors phosphodiesterase V inhibitor phosphodiesterase V inhibitors type 5 phosphodiesterase inhibitor type 5 phosphodiesterase inhibitors EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor EC 3.5.1.88 (peptide deformylase) inhibitor EC 3.5.1.88 (peptide deformylase) inhibitors EC 3.5.1.88 inhibitor EC 3.5.1.88 inhibitors PDF inhibitors formyl-L-methionyl peptide amidohydrolase inhibitor formyl-L-methionyl peptide amidohydrolase inhibitors peptide deformylase (EC 3.5.1.88) inhibitor peptide deformylase (EC 3.5.1.88) inhibitors peptide deformylase inhibitor peptide deformylase inhibitors EC 3.5.1.88 (peptide deformylase) inhibitor nerve growth factor stimulator NGF stimulator NGF stimulators nerve growth factor stimulators nerve growth factor stimulator MTP inhibitor MTP inhibitors MTTP inhibitor MTTP inhibitors microsomal triglyceride transfer protein inhibitor microsomal triglyceride transfer protein inhibitors MTP inhibitor glucagon-like peptide-2 receptor agonist GLP-2 receptor agonist GLP-2 receptor agonists glucagon-like peptide-2 receptor agonists glucagon-like peptide-2 receptor agonist virulence factor virulence factors virulence factor provitamin B1 provitamin B1s provitamin B1 vesicular glutamate transport inhibitor vesicular glutamate transport inhibitors vesicular glutamate transporter 1 inhibitor vesicular glutamate transporter 1 inhibitors vesicular glutamate transport inhibitor pro-angiogenic agent angiogenesis inducing agent angiogenesis inducing agents pro-angiogenic agents proangiogenic agent proangiogenic agents pro-angiogenic agent alarm pheromone alarm pheromones alarm signal alarm signals alarm substance alarm substances alarm pheromone EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitors EC 2.3.2.13 inhibitor EC 2.3.2.13 inhibitors Factor XIIIa inhibitor R-glutaminyl-peptide:amine gamma-glutamyl transferase inhibitor TG-2 inhibitor TG-2 inhibitors TG2 inhibitor TG2 inhibitors TGase inhibitor TGase inhibitors fibrin stabilizing factor inhibitor fibrin stabilizing factor inhibitors fibrinoligase inhibitor fibrinoligase inhibitors glutaminylpeptide gamma-glutamyltransferase inhibitor glutaminylpeptide gamma-glutamyltransferase inhibitors polyamine transglutaminase inhibitor polyamine transglutaminase inhibitors protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) inhibitor protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) inhibitors protein-glutamine gamma-glutamyltransferase inhibitor protein-glutamine gamma-glutamyltransferase inhibitors protein-glutamine:amine gamma-glutamyltransferase inhibitor protein-glutamine:amine gamma-glutamyltransferase inhibitors tissue transglutaminase inhibitor tissue transglutaminase inhibitors transglutaminase inhibitor transglutaminase inhibitors transglutaminase-2 inhibitor transglutaminase-2 inhibitors EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor aryl hydrocarbon receptor agonist AHR agonist AHR agonists AhR agonist AhR agonists aryl hydrocarbon receptor agonists aryl hydrocarbon receptor agonist breast cancer resistance protein inhibitor ABCG2 inhibitor ABCG2 inhibitors breast cancer resistance protein inhibitors breast cancer resistance protein inhibitor carotogenesis inhibitor carotogenesis inhibitors carotogenesis inhibitor EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor 15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) inhibitor 15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) inhibitors 2-step phytoene desaturase inhibitor 2-step phytoene desaturase inhibitors CrtIa inhibitor CrtIa inhibitors EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitors EC 1.3.99.29 inhibitor EC 1.3.99.29 inhibitors phytoene dehydrogenase inhibitor phytoene dehydrogenase inhibitors phytoene desaturase (zeta-carotene-forming) (EC 1.3.99.29) inhibitor phytoene desaturase (zeta-carotene-forming) (EC 1.3.99.29) inhibitors phytoene desaturase (zeta-carotene-forming) inhibitor phytoene desaturase (zeta-carotene-forming) inhibitors phytoene desaturase inhibitor phytoene desaturase inhibitors two-step phytoene desaturase inhibitor two-step phytoene desaturase inhibitors EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitor D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitors EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitors EC 1.13.11.52 inhibitor EC 1.13.11.52 inhibitors IDO inhibitor IDO inhibitors indoleamine 2,3-dioxygenase (EC 1.13.11.52) inhibitor indoleamine 2,3-dioxygenase (EC 1.13.11.52) inhibitors indoleamine 2,3-dioxygenase inhibitor indoleamine 2,3-dioxygenase inhibitors EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor ALR3 inhibitor ALR3 inhibitors EC 1.1.1.184 (carbonyl reductase (NADPH)) inhibitor EC 1.1.1.184 (carbonyl reductase (NADPH)) inhibitors EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitors EC 1.1.1.184 inhibitor EC 1.1.1.184 inhibitors NADPH2-dependent carbonyl reductase inhibitor NADPH2-dependent carbonyl reductase inhibitors aldehyde reductase 1 inhibitor aldehyde reductase 1 inhibitors carbonyl reductase (NADPH) (EC 1.1.1.184) inhibitor carbonyl reductase (NADPH) (EC 1.1.1.184) inhibitors carbonyl reductase (NADPH) inhibitor carbonyl reductase (NADPH) inhibitors carbonyl reductase (NADPH2) inhibitor carbonyl reductase (NADPH2) inhibitors carbonyl reductase inhibitor carbonyl reductase inhibitors nonspecific NADPH-dependent carbonyl reductase inhibitor nonspecific NADPH-dependent carbonyl reductase inhibitors prostaglandin 9-ketoreductase inhibitor prostaglandin 9-ketoreductase inhibitors secondary-alcohol:NADP+ oxidoreductase inhibitor secondary-alcohol:NADP+ oxidoreductase inhibitors xenobiotic ketone reductase inhibitor xenobiotic ketone reductase inhibitors EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor EC 1.11.1.11 (L-ascorbate peroxidase) inhibitors EC 1.11.1.11 inhibitor EC 1.11.1.11 inhibitors L-ascorbate peroxidase (EC 1.11.1.11) inhibitor L-ascorbate peroxidase (EC 1.11.1.11) inhibitors L-ascorbate peroxidase inhibitor L-ascorbate peroxidase inhibitors L-ascorbate:hydrogen-peroxide oxidoreductase inhibitor L-ascorbate:hydrogen-peroxide oxidoreductase inhibitors L-ascorbic acid peroxidase inhibitor L-ascorbic acid peroxidase inhibitors L-ascorbic acid-specific peroxidase inhibitor L-ascorbic acid-specific peroxidase inhibitors ascorbate peroxidase inhibitor ascorbate peroxidase inhibitors ascorbic acid peroxidase inhibitor ascorbic acid peroxidase inhibitors EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor plant activator plant activators plant activator brassinosteroid biosynthesis inhibitor brassinosteroid biosynthesis inhibitors brassinosteroid biosynthesis inhibitor antimutagen antimutagenic agent antimutagenic agents antimutagens antimutagen abscisic acid receptor agonist ABA agonist ABA agonists ABA receptor agonist ABA receptor agonists abscisic acid receptor agonists abscisic acid receptor agonist EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitors EC 1.3.3.4 inhibitor EC 1.3.3.4 inhibitors HemG inhibitor HemG inhibitors HemY inhibitor HemY inhibitors PPO inhibitor PPO inhibitors Protox inhibitor Protox inhibitors protoporphyrinogen IX oxidase inhibitor protoporphyrinogen IX oxidase inhibitors protoporphyrinogen oxidase (EC 1.3.3.4) inhibitor protoporphyrinogen oxidase (EC 1.3.3.4) inhibitors protoporphyrinogen oxidase inhibitor protoporphyrinogen oxidase inhibitors protoporphyrinogen-IX:oxygen oxidoreductase inhibitor protoporphyrinogen-IX:oxygen oxidoreductase inhibitors protoporphyrinogenase inhibitor protoporphyrinogenase inhibitors EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor gibberellin biosynthesis inhibitor gibberellin biosynthesis inhibitors gibberellin biosynthesis inhibitor EC 4.4.1.11 (methionine gamma-lyase) inhibitor EC 4.4.1.11 (methionine gamma-lyase) inhibitors L-methioninase inhibitor L-methioninase inhibitors methioninase inhibitor methioninase inhibitors methionine gamma-lyase (EC 4.4.1.11) inhibitor methionine gamma-lyase (EC 4.4.1.11) inhibitors methionine gamma-lyase inhibitor methionine gamma-lyase inhibitors EC 4.4.1.11 (methionine gamma-lyase) inhibitor EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor ATP phosphohydrolase (H(+)-transporting) inhibitor ATP phosphohydrolase (H(+)-transporting) inhibitors ATP synthase inhibitor ATP synthase inhibitors EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitors EC 3.6.3.14 inhibitor EC 3.6.3.14 inhibitors F1-ATPase inhibitor F1-ATPase inhibitors FoF1-ATPase inhibitor FoF1-ATPase inhibitors H(+)-transporting ATPase inhibitor H(+)-transporting ATPase inhibitors H(+)-transporting two-sector ATPase (EC 3.6.3.14) inhibitor H(+)-transporting two-sector ATPase (EC 3.6.3.14) inhibitors H(+)-transporting two-sector ATPase inhibitor H(+)-transporting two-sector ATPase inhibitors bacterial Ca(2+)/Mg(2+) ATPase inhibitor bacterial Ca(2+)/Mg(2+) ATPase inhibitors chloroplast ATPase inhibitor chloroplast ATPase inhibitors coupling factors (Fo, F1 and CF1) inhibitor coupling factors (Fo, F1 and CF1) inhibitors mitochondrial ATPase inhibitor mitochondrial ATPase inhibitors EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor EC 3.6 inhibitor EC 3.6 inhibitors EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors EC 3.6.* inhibitor EC 3.6.* inhibitors EC 3.6.*.* inhibitor EC 3.6.*.* inhibitors acid anhydride hydrolase inhibitor acid anhydride hydrolase inhibitors inhibitor of hydrolase acting on acid anhydride (EC 3.6.*) inhibitors of hydrolase acting on acid anhydride (EC 3.6.*) EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor NF-kappaB inhibitor NF-kappaB inhibitors nuclear factor kappa-light-chain-enhancer of activated B cells inhibitor nuclear factor kappa-light-chain-enhancer of activated B cells inhibitors NF-kappaB inhibitor cyclooxygenase 3 inhibitor COX-3 inhibitor COX-3 inhibitors cyclo-oxygenase 3 inhibitor cyclo-oxygenase 3 inhibitors cyclooxygenase 3 inhibitors cyclooxygenase-3 inhibitor cyclooxygenase-3 inhibitors cyclooxygenase 3 inhibitor oxidative phosphorylation inhibitor oxidative phosphorylation inhibitors oxidative phosphorylation inhibitor sodium-glucose transport protein subtype 2 inhibitor SGLT2 inhibitor SGLT2 inhibitors sodium glucose co-transporter 2 inhibitor sodium glucose co-transporter 2 inhibitors sodium-glucose transport protein subtype 2 inhibitors sodium-glucose transport protein subtype 2 inhibitor cholecystokinin antagonist CCK antagonist CCK antagonists cholecystokinin antagonists cholecystokinin antagonist adenosine A2A receptor agonist A2A agonist A2A agonists A2A receptor agonist A2A receptor agonists adenosine A2A receptor agonists adenosine A2A receptor agonist adenosine receptor agonist adenosine receptor agonist adenosine receptor agonist adenosine A3 receptor agonist A3 agonist A3 agonists A3 receptor agonist A3 receptor agonists adenosine A3 receptor agonists adenosine A3 receptor agonist scabicide scabicides scabicide thyroid hormone agonist thyroid hormone agonists thyromimetic thyromimetics thyroid hormone agonist ultraviolet filter UV filter UV filters ultraviolet filters ultraviolet filter vulnerary vulneraries wound-healing agent wound-healing agents wound-healing drug wound-healing drugs vulnerary protein-sequencing agent protein-sequencing agents sequencing agent sequencing agents protein-sequencing agent EC 2.7.3.2 (creatine kinase) inhibitor CK inhibitor CK inhibitors CPK inhibitor CPK inhibitors EC 2.7.3.2 (creatine kinase) inhibitors creatine kinase (EC 2.7.3.2) inhibitor creatine kinase (EC 2.7.3.2) inhibitors creatine kinase inhibitor creatine kinase inhibitors creatine phosphokinase inhibitor creatine phosphokinase inhibitors EC 2.7.3.2 (creatine kinase) inhibitor EC 3.4.11.18 (methionyl aminopeptidase) inhibitor EC 3.4.11.18 (methionyl aminopeptidase) inhibitors EC 3.4.11.18 inhibitor EC 3.4.11.18 inhibitors L-methionine aminopeptidase inhibitor L-methionine aminopeptidase inhibitors MAP inhibitor MAP inhibitors methionine aminopeptidase inhibitor methionine aminopeptidase inhibitors methionyl aminopeptidase (EC 3.4.11.18) inhibitor methionyl aminopeptidase (EC 3.4.11.18) inhibitors methionyl aminopeptidase inhibitor methionyl aminopeptidase inhibitors peptidase M inhibitor peptidase M inhibitors EC 3.4.11.18 (methionyl aminopeptidase) inhibitor methionine aminopeptidase 2 inhibitor MAP2 inhibitor MAP2 inhibitors METAP2 inhibitor METAP2 inhibitors MetAP2 inhibitor MetAP2 inhibitors methionine aminopeptidase 2 inhibitors methionine aminopeptidase-2 inhibitor methionine aminopeptidase-2 inhibitors methionine aminopeptidase 2 inhibitor cannabinoid receptor antagonist cannabinoid receptor antagonists cannabinoid receptor antagonist CB1 receptor antagonist CB1 receptor antagonist CB1 receptor antagonists CB1R antagonist CB1R antagonists cannabinoid receptor 1 antagonist cannabinoid receptor 1 antagonists cannabinoid receptor type 1 antagonist cannabinoid receptor type 1 antagonists type 1 cannabinoid receptor antagonist type 1 cannabinoid receptor antagonists CB1 receptor antagonist CB2 receptor antagonist CB2 receptor antagonist CB2 receptor antagonists CB2R antagonist CB2R antagonists cannabinoid receptor 2 antagonist cannabinoid receptor 2 antagonists cannabinoid receptor type 2 antagonist cannabinoid receptor type 2 antagonists type 2 cannabinoid receptor antagonist type 2 cannabinoid receptor antagonists CB2 receptor antagonist kynuramine 2',3-diaminopropiophenone 3-amino-1-(2-aminophenyl)-1-propanone 3-amino-1-(2-aminophenyl)propan-1-one kynurenamine kynuramine spectrophotometric reagent spectrophotometric reagents spectrophotometric reagent tolerogen tolerogens tolerogen peptide coupling reagent peptide coupling reagents peptide coupling reagent PPARbeta/delta agonist NR1C2 agonist NR1C2 agonists PPAR(beta/delta) agonist PPAR(beta/delta) agonists PPAR-beta agonist PPAR-beta agonists PPAR-beta/delta agonist PPAR-beta/delta agonists PPAR-delta agonist PPAR-delta agonists PPARD agonist PPARD agonists PPARD receptor agonist PPARD receptor agonists PPARbeta agonist PPARbeta agonists PPARbeta/delta agonist PPARbeta/delta agonists PPARdelta agonist PPARdelta agonists nuclear receptor subfamily 1, group C, member 2 agonist nuclear receptor subfamily 1, group C, member 2 agonists peroxisome proliferator-activated receptor-beta agonist peroxisome proliferator-activated receptor-beta agonists peroxisome proliferator-activated receptor-delta agonist peroxisome proliferator-activated receptor-delta agonists PPARbeta/delta agonist vibriostatic agent vibriostatic vibriostatics vibriostatic agent antifolate antifolates folic acid antagonist folic acid antagonists antifolate nitric oxide synthase activator NOS activator NOS activators nitric oxide synthase activators nitric oxide synthase activator lachrymator lachrymators lachrymator mordant mordant EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitor 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitors ADP reductase inhibitor ADP reductase inhibitors CDP reductase inhibitor CDP reductase inhibitors EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitors EC 1.17.4.1 inhibitor EC 1.17.4.1 inhibitors RR inhibitor RR inhibitors UDP reductase inhibitor UDP reductase inhibitors nucleoside diphosphate reductase inhibitor nucleoside diphosphate reductase inhibitors ribonucleoside diphosphate reductase inhibitor ribonucleoside diphosphate reductase inhibitors ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitor ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitors ribonucleoside-diphosphate reductase inhibitor ribonucleoside-diphosphate reductase inhibitors ribonucleotide diphosphate reductase inhibitor ribonucleotide diphosphate reductase inhibitors ribonucleotide reductase inhibitor ribonucleotide reductase inhibitors EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor 7,8-dihydrobiopterin:NADP(+) oxidoreductase 7,8-dihydrobiopterin:NADP(+) oxidoreductases EC 1.1.1.153 (sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)) inhibitor EC 1.1.1.153 (sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)) inhibitors EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitors L-erythro-7,8-dihydrobiopterin:NADP(+) oxidoreductase inhibitor L-erythro-7,8-dihydrobiopterin:NADP(+) oxidoreductase inhibitors sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) (EC 1.1.1.153) inhibitor sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) (EC 1.1.1.153) inhibitors sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) inhibitor sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) inhibitors sepiapterin reductase inhibitor sepiapterin reductase inhibitors EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor polymerisation monomer polymerization monomer polymerisation monomer quinol oxidation site inhibitor QP site inhibitor QP site inhibitors quinol oxidation site inhibitors quinol oxidation site inhibitor epidermal growth factor receptor antagonist EGFR antagonoist EGFR antagonoists EGFR inhibitor EGFR inhibitors epidermal growth factor receptor antagonists epidermal growth factor receptor inhibitor epidermal growth factor receptor inhibitors epidermal growth factor receptor antagonist anti-obesity agent anti-obesity agents anti-obestic agent anti-obestic agents anti-obesity agent EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor 6-phospho-D-gluconate dehydrogenase inhibitor 6-phospho-D-gluconate dehydrogenase inhibitors 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) inhibitor 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) inhibitors 6-phosphogluconate dehydrogenase (decarboxylating) inhibitor 6-phosphogluconate dehydrogenase (decarboxylating) inhibitors 6-phosphogluconic carboxylase inhibitor 6-phosphogluconic carboxylase inhibitors 6-phosphogluconic dehydrogenase inhibitor 6-phosphogluconic dehydrogenase inhibitors EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitors EC 1.1.1.44 inhibitor EC 1.1.1.44 inhibitors NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase (EC 1.1.1.44) inhibitor NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase (EC 1.1.1.44) inhibitors NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase inhibitor NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase inhibitors phosphogluconate dehydrogenase (NADP+ -dependent, decarboxylating) inhibitor phosphogluconate dehydrogenase (NADP+ -dependent, decarboxylating) inhibitors phosphogluconic acid dehydrogenase inhibitor phosphogluconic acid dehydrogenase inhibitors EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor antidote to paracetamol poisoning Tylenol poisoning antidote Tylenol poisoning antidotes acetaminophen poisoning antidote acetaminophen poisoning antidotes antidote to Tylenol poisoning antidote to acetaminophen poisoning antidotes to Tylenol poisoning antidotes to acetaminophen poisoning antidotes to paracetamol poisoning paracetamol poisoning antidote paracetamol poisoning antidotes antidote to paracetamol poisoning antidote to curare poisoning antidote to curare antidote to tubocurarine antidote to tubocurarine poisoning antidotes to curare antidotes to curare poisoning antidotes to tubocurarine antidotes to tubocurarine poisoning curare antidote curare antidotes curare poisoning antidote curare poisoning antidotes tubocurarine antidote tubocurarine antidotes antidote to curare poisoning EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase inhibitor (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase inhibitors EC 2.3.2.2 (gamma-glutamyltransferase) inhibitors EC 2.3.2.2 inhibitor EC 2.3.2.2 inhibitors GGT inhibitor GGT inhibitors L-gamma-glutamyl transpeptidase inhibitor L-gamma-glutamyl transpeptidase inhibitors L-gamma-glutamyltransferase inhibitor L-gamma-glutamyltransferase inhibitors L-glutamyltransferase inhibitor L-glutamyltransferase inhibitors alpha-glutamyl transpeptidase inhibitor alpha-glutamyl transpeptidase inhibitors gamma-GPT inhibitor gamma-GPT inhibitors gamma-GT inhibitor gamma-GT inhibitors gamma-GTP inhibitor gamma-GTP inhibitors gamma-glutamyl peptidyltransferase inhibitor gamma-glutamyl peptidyltransferase inhibitors gamma-glutamyl transpeptidase inhibitor gamma-glutamyl transpeptidase inhibitors gamma-glutamyltransferase (EC 2.3.2.2) inhibitor gamma-glutamyltransferase (EC 2.3.2.2) inhibitors gamma-glutamyltransferase inhibitor gamma-glutamyltransferase inhibitors gamma-glutamyltranspeptidase inhibitor gamma-glutamyltranspeptidase inhibitors glutamyl transpeptidase inhibitor glutamyl transpeptidase inhibitors EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor astringent adstringent adstringents astringents astringent neoglycolipid probe neoglycolipid probe microarray analysis reagent microarray analysis reagents microarray analysis reagent EC 3.4.23.46 (memapsin 2) inhibitor BACE1 inhibitor BACE1 inhibitors EC 3.4.23.46 (memapsin 2) inhibitors EC 3.4.23.46 inhibitor EC 3.4.23.46 inhibitors Gamma-secretase inhibitor Gamma-secretase inhibitors beta-secretase inhibitor beta-secretase inhibitors beta-site APP-cleaving enzyme 1 inhibitor beta-site APP-cleaving enzyme 1 inhibitors beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 inhibitor beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 inhibitors gamma-secretase inhibitor gamma-secretase inhibitors memapsin 2 (EC 3.4.23.46) inhibitor memapsin 2 (EC 3.4.23.46) inhibitors memapsin 2 inhibitor memapsin 2 inhibitors membrane-associated aspartic protease 2 inhibitor membrane-associated aspartic protease 2 inhibitors EC 3.4.23.46 (memapsin 2) inhibitor EC 3.1.27.3 (ribonuclease T1) inhibitor Aspergillus oryzae ribonuclease inhibitor Aspergillus oryzae ribonuclease inhibitors EC 3.1.27.3 (ribonuclease T1) inhibitors EC 3.1.27.3 inhibitor EC 3.1.27.3 inhibitors RNase F1 inhibitor RNase F1 inhibitors RNase G inhibitor RNase G inhibitors RNase N1 inhibitor RNase N1 inhibitors RNase N2 inhibitor RNase N2 inhibitors RNase Sa inhibitor RNase Sa inhibitors RNase T1 inhibitor RNase T1 inhibitors T1 inhibitor T1 inhibitors binase inhibitor binase inhibitors guanyl-specific RNase inhibitor guanyl-specific RNase inhibitors guanyloribonuclease inhibitor guanyloribonuclease inhibitors ribonuclease C2 inhibitor ribonuclease C2 inhibitors ribonuclease Ch inhibitor ribonuclease Ch inhibitors ribonuclease F1 inhibitor ribonuclease F1 inhibitors ribonuclease N1 inhibitor ribonuclease N1 inhibitors ribonuclease N3 inhibitor ribonuclease N3 inhibitors ribonuclease PP1 inhibitor ribonuclease PP1 inhibitors ribonuclease SA inhibitor ribonuclease SA inhibitors ribonuclease T1 (EC 3.1.27.3) inhibitor ribonuclease T1 (EC 3.1.27.3) inhibitors ribonuclease T1 inhibitor ribonuclease T1 inhibitors ribonuclease U1 inhibitor ribonuclease U1 inhibitors ribonuclease guaninenucleotido-2'-transferase (cyclising) inhibitor ribonuclease guaninenucleotido-2'-transferase (cyclising) inhibitors ribonuclease guaninenucleotido-2'-transferase (cyclizing) inhibitor ribonuclease guaninenucleotido-2'-transferase (cyclizing) inhibitors EC 3.1.27.3 (ribonuclease T1) inhibitor B-Raf inhibitor B-Raf inhibitors BRAF inhibitor BRAF inhibitors human mutant serine/threonine kinase inhibitor human mutant serine/threonine kinase inhibitors B-Raf inhibitor chromogenic compound chromogen chromogenic compounds chromogens chromogenic compound EC 2.5.1.21 (squalene synthase) inhibitor EC 2.5.1.21 (squalene synthase) inhibitors EC 2.5.1.21 inhibitor EC 2.5.1.21 inhibitors SQS inhibitor SQS inhibitors farnesyl-diphosphate farnesyltransferase inhibitor farnesyl-diphosphate farnesyltransferase inhibitors farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase inhibitor farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase inhibitors farnesyltransferase inhibitor farnesyltransferase inhibitors presqualene synthase inhibitor presqualene synthase inhibitors presqualene-diphosphate synthase inhibitor presqualene-diphosphate synthase inhibitors squalene synthase (EC 2.5.1.21) inhibitor squalene synthase (EC 2.5.1.21) inhibitors squalene synthase inhibitor squalene synthase inhibitors squalene synthetase inhibitor squalene synthetase inhibitors EC 2.5.1.21 (squalene synthase) inhibitor EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitors EC 5.4.3.2 inhibitor EC 5.4.3.2 inhibitors L-lysine 2,3-aminomutase inhibitor L-lysine 2,3-aminomutase inhibitors lysine 2,3-aminomutase (EC 5.4.3.2) inhibitor lysine 2,3-aminomutase (EC 5.4.3.2) inhibitors lysine 2,3-aminomutase inhibitor lysine 2,3-aminomutase inhibitors EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor insulin-like growth factor receptor 1 antagonist IGF-1R antagonist IGF-1R antagonists insulin-like growth factor receptor 1 antagonists insulin-like growth factor receptor 1 antagonist ergosterol biosynthesis inhibitor ergosterol biosynthesis inhibitors ergosterol biosynthesis inhibitor histamine releasing agent histamine releasing agents histamine releasing compound histamine releasing compounds histamine releasing substance histamine releasing substances histamine releasing agent excipient bulking agent bulking agents excipient filler fillers excipient cathartic cathartics cathartic curing agent curing agents vulcanization agent vulcanization agents vulcanizing agent vulcanizing agents curing agent EC 1.11.1.6 (catalase) inhibitor CAT inhibitor CAT inhibitors EC 1.11.1.6 (catalase) inhibitors EC 1.11.1.6 inhibitor EC 1.11.1.6 inhibitors caperase inhibitor caperase inhibitors catalase (EC 1.11.1.6) inhibitor catalase (EC 1.11.1.6) inhibitors catalase inhibitor catalase inhibitors catalase-peroxidase inhibitor catalase-peroxidase inhibitors equilase inhibitor equilase inhibitors hydrogen-peroxide:hydrogen-peroxide oxidoreductase inhibitor hydrogen-peroxide:hydrogen-peroxide oxidoreductase inhibitors optidase inhibitor optidase inhibitors EC 1.11.1.6 (catalase) inhibitor EC 1.11.1.* (peroxidases) inhibitor EC 1.11.1 inhibitor EC 1.11.1 inhibitors EC 1.11.1.* (peroxidase) inhibitor EC 1.11.1.* (peroxidase) inhibitors EC 1.11.1.* (peroxidases) inhibitors EC 1.11.1.* inhibitor EC 1.11.1.* inhibitors inhibitor of peroxidases inhibitors of peroxidases peroxidases inhibitors EC 1.11.1.* (peroxidases) inhibitor platelet-activating factor receptor agonist platelet-activating factor receptor agonists platelet-activating factor receptor agonist EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitors EC 6.1.1.* inhibitor EC 6.1.1.* inhibitors aminoacyl tRNA synthetase inhibitor aminoacyl tRNA synthetase inhibitors ligases forming aminoacyl tRNA and related compounds (EC 6.1.1.*) inhibitor ligases forming aminoacyl tRNA and related compounds (EC 6.1.1.*) inhibitors tRNA synthetase inhibitor tRNA synthetase inhibitors EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor EC 1.4.4.2 [glycine dehydrogenase (aminomethyl-transferring)] inhibitor EC 1.4.4.2 (glycine dehydrogenase (aminomethyl-transferring)) inhibitor EC 1.4.4.2 (glycine dehydrogenase (aminomethyl-transferring)) inhibitors EC 1.4.4.2 [glycine dehydrogenase (aminomethyl-transferring)] inhibitors EC 1.4.4.2 inhibitor EC 1.4.4.2 inhibitors P-protein inhibitor P-protein inhibitors glycine cleavage system P-protein inhibitor glycine cleavage system P-protein inhibitors glycine decarboxylase inhibitor glycine decarboxylase inhibitors glycine dehydrogenase (aminomethyl-transferring) (EC 1.4.4.2) inhibitor glycine dehydrogenase (aminomethyl-transferring) (EC 1.4.4.2) inhibitors glycine dehydrogenase (aminomethyl-transferring) inhibitor glycine dehydrogenase (aminomethyl-transferring) inhibitors glycine dehydrogenase (decarboxylating) inhibitor glycine dehydrogenase (decarboxylating) inhibitors glycine-cleavage complex P-protein inhibitor glycine-cleavage complex P-protein inhibitors glycine-cleavage complex inhibitor glycine-cleavage complex inhibitors glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating) glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating) inhibitor glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) inhibitor glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) inhibitors protein P1 inhibitor protein P1 inhibitors EC 1.4.4.2 [glycine dehydrogenase (aminomethyl-transferring)] inhibitor EC 6.1.1.11 (serine--tRNA ligase) inhibitor EC 6.1.1.11 (serine--tRNA ligase) inhibitor EC 6.1.1.11 (serine--tRNA ligase) inhibitors EC 6.1.1.11 inhibitor EC 6.1.1.11 inhibitors L-serine:tRNA(Ser) ligase (AMP-forming) inhibitor L-serine:tRNA(Ser) ligase (AMP-forming) inhibitors SerRS inhibitor SerRS inhibitors serine translase inhibitor serine translase inhibitors serine--tRNA ligase (EC 6.1.1.11) inhibitor serine--tRNA ligase (EC 6.1.1.11) inhibitors serine--tRNA ligase inhibitor serine--tRNA ligase inhibitors seryl-tRNA synthetase inhibitor seryl-tRNA synthetase inhibitors seryl-transfer RNA synthetase inhibitor seryl-transfer RNA synthetase inhibitors seryl-transfer ribonucleate synthetase inhibitor seryl-transfer ribonucleate synthetase inhibitors seryl-transfer ribonucleic acid synthetase inhibitor seryl-transfer ribonucleic acid synthetase inhibitors EC 6.1.1.11 (serine--tRNA ligase) inhibitor EC 5.1.1.1 (alanine racemase) inhibitor EC 5.1.1.1 (alanine racemase) inhibitors EC 5.1.1.1 inhibitor EC 5.1.1.1 inhibitors L-alanine racemase inhibitor L-alanine racemase inhibitors alanine racemase (EC 5.1.1.1) inhibitor alanine racemase (EC 5.1.1.1) inhibitors alanine racemase inhibitor alanine racemase inhibitors EC 5.1.1.1 (alanine racemase) inhibitor EC 5.* (isomerase) inhibitor EC 5.* (isomerase) inhibitors EC 5.* inhibitor EC 5.* inhibitors EC 5.*.*.* inhibitor EC 5.*.*.* inhibitors isomerase (EC 5.*) inhibitor isomerase (EC 5.*) inhibitors isomerase inhibitor isomerase inhibitors EC 5.* (isomerase) inhibitor EC 6.3.2.4 (D-alanine--D-alanine ligase) inhibitor D-alanine--D-alanine ligase (EC 6.3.2.4) inhibitor D-alanine--D-alanine ligase (EC 6.3.2.4) inhibitors D-alanine--D-alanine ligase inhibitor D-alanine--D-alanine ligase inhibitors D-alanine:D-alanine ligase (ADP-forming) inhibitor D-alanine:D-alanine ligase (ADP-forming) inhibitors EC 6.3.2.4 (D-alanine--D-alanine ligase) inhibitors EC 6.3.2.4 inhibitor EC 6.3.2.4 inhibitors alanine:alanine ligase (ADP-forming) inhibitor alanine:alanine ligase (ADP-forming) inhibitors alanylalanine synthetase inhibitor alanylalanine synthetase inhibitors EC 6.3.2.4 (D-alanine--D-alanine ligase) inhibitor EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor EC 6.3.2.2 (glutamate--cysteine ligase) inhibitors EC 6.3.2.2 inhibitor EC 6.3.2.2 inhibitors gamma-glutamyl-L-cysteine synthetase inhibitor gamma-glutamyl-L-cysteine synthetase inhibitors gamma-glutamylcysteine synthetase inhibitor gamma-glutamylcysteine synthetase inhibitors gamma-glutamylcysteinyl synthetase inhibitor gamma-glutamylcysteinyl synthetase inhibitors glutamate--cysteine ligase (EC 6.3.2.2) inhibitor glutamate--cysteine ligase (EC 6.3.2.2) inhibitors glutamate--cysteine ligase inhibitor glutamate--cysteine ligase inhibitors EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor EC 6.3.* (C-N bond-forming ligase) inhibitor C--N bond-forming ligase inhibitor C--N bond-forming ligase inhibitors C-N bond-forming ligase (EC 6.3.*) inhibitor C-N bond-forming ligase (EC 6.3.*) inhibitors C-N bond-forming ligase inhibitor C-N bond-forming ligase inhibitors EC 6.3.* (C-N bond-forming ligase) inhibitorS EC 6.3.* inhibitor EC 6.3.* inhibitors EC 6.3.*.* inhibitor EC 6.3.*.* inhibitors EC 6.3.* (C-N bond-forming ligase) inhibitor EC 6.* (ligase) inhibitor EC 6.* (ligase) inhibitors EC 6.* inhibitor EC 6.* inhibitors EC 6.*.*.* inhibitor EC 6.*.*.* inhibitors ligase inhibitor ligase inhibitors EC 6.* (ligase) inhibitor EC 6.4.* (C-C bond-forming ligase) inhibitor C--C bond-forming ligase inhibitor C--C bond-forming ligase inhibitors C-C bond-forming ligase (EC 6.4.*) inhibitor C-C bond-forming ligase (EC 6.4.*) inhibitorS C-C bond-forming ligase inhibitor C-C bond-forming ligase inhibitors EC 6.4.* (C-C bond-forming ligase) inhibitorS EC 6.4.* inhibitor EC 6.4.* inhibitors EC 6.4.*.* inhibitor EC 6.4.*.* inhibitors EC 6.4.* (C-C bond-forming ligase) inhibitor EC 6.5.* (phosphoric ester bond-forming ligase) inhibitor EC 6.5.* (phosphoric ester bond-forming ligase) inhibitors EC 6.5.* inhibitor EC 6.5.* inhibitors EC 6.5.*.* inhibitor EC 6.5.*.* inhibitors phosphoric ester bond-forming ligase (EC 6.5.*) inhibitor phosphoric ester bond-forming ligase (EC 6.5.*) inhibitors phosphoric ester bond-forming ligase inhibitor phosphoric ester bond-forming ligase inhibitors EC 6.5.* (phosphoric ester bond-forming ligase) inhibitor nifedipine 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester Adalat Adapine Coracten Nifecard Nifecor Nifedipine Nifedipres Procardia dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate nifedipine nifedipino nifedipinum nifedipine eukaryotic metabolite eukaryotic metabolites eukaryotic metabolite animal metabolite animal metabolites animal metabolite mammalian metabolite mammalian metabolites mammalian metabolite mouse metabolite Mus musculus metabolite Mus musculus metabolites mouse metabolites mouse metabolite Saccharomyces cerevisiae metabolite S. cerevisiae metabolite S. cerevisiae metabolites S. cerevisiae secondary metabolite S. cerevisiae secondary metabolites Saccharomyces cerevisiae metabolites Saccharomyces cerevisiae secondary metabolites baker's yeast metabolite baker's yeast metabolites baker's yeast secondary metabolite baker's yeast secondary metabolites Saccharomyces cerevisiae metabolite prokaryotic metabolite prokaryotic metabolites prokaryotic metabolite anti-anaemic agent anti-anaemic agents anti-anaemic drug anti-anaemic drugs anti-anemia agent anti-anemia agents anti-anemia drug anti-anemia drugs anti-anemic agent anti-anemic agents anti-anemic drug anti-anemic drugs antianaemia agent antianaemia agents antianaemia drug antianaemia drugs antianaemic agent antianaemic agents antianaemic drug antianaemic drugs antianemia drug antianemia drugs anti-anaemic agent EC 6.3.2.19 (ubiquitin--protein ligase) inhibitor EC 6.3.2.19 (ubiquitin--protein ligase) inhibitors EC 6.3.2.19 inhibitor EC 6.3.2.19 inhibitors S-phase kinase-associated protein 2 inhibitor S-phase kinase-associated protein 2 inhibitors Skp2 inhibitor Skp2 inhibitors ubiquitin--protein ligase inhibitor ubiquitin--protein ligase inhibitors ubiquitin-activating enzyme inhibitor ubiquitin-activating enzyme inhibitors ubiquitin:protein-lysine N-ligase (AMP-forming) inhibitor ubiquitin:protein-lysine N-ligase (AMP-forming) inhibitors EC 6.3.2.19 (ubiquitin--protein ligase) inhibitor soluble guanylate cyclase activator sGC activator sGC activators soluble guanylate cyclase activators soluble guanylyl cyclase activator soluble guanylyl cyclase activators soluble guanylate cyclase activator xenobiotic metabolite xenobiotic metabolites xenobiotic metabolite fluorogen fluorogen EC 2.3.1.48 (histone acetyltransferase) inhibitor EC 2.3.1.48 (histone acetyltransferase) inhibitors EC 2.3.1.48 inhibitor EC 2.3.1.48 inhibitors HAT inhibitor HAT inhibitors acetyl-CoA:histone acetyltransferase inhibitor acetyl-CoA:histone acetyltransferase inhibitors histone acetokinase inhibitor histone acetokinase inhibitors histone acetylase inhibitor histone acetylase inhibitors histone acetyltransferase (EC 2.3.1.48) inhibitor histone acetyltransferase (EC 2.3.1.48) inhibitors histone acetyltransferase inhibitor histone acetyltransferase inhibitors histone transacetylase inhibitor histone transacetylase inhibitors nucleosome-histone acetyltransferase inhibitor nucleosome-histone acetyltransferase inhibitors EC 2.3.1.48 (histone acetyltransferase) inhibitor greenhouse gas greenhouse gases greenhouse gas propellant propellants propellant coral metabolite coral metabolites coral metabolite marine metabolite marine metabolites marine metabolite odorant receptor antagonist odorant receptor antagonists odorant receptor blocker odorant receptor blockers odorant receptor antagonist nephroprotective agent nephroprotective agents nephroprotective agent EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor ABL inhibitor ABL inhibitors ABL1 inhibitor ABL1 inhibitors ABL2 inhibitor ABL2 inhibitors ABLL inhibitor ABLL inhibitors ACK1 inhibitor ACK1 inhibitors ACK2 inhibitor ACK2 inhibitors AGMX1 inhibitor AGMX1 inhibitors ARG inhibitor ARG inhibitors ATK inhibitor ATK inhibitors ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) inhibitor ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) inhibitors BLK inhibitor BLK inhibitors BMX inhibitor BMX inhibitors BRK inhibitor BRK inhibitors BTK inhibitor BTK inhibitors BTKL inhibitor BTKL inhibitors Bmk inhibitor Bmk inhibitors Bruton's tyrosine kinase inhibitor Bruton's tyrosine kinase inhibitors Bsk inhibitor Bsk inhibitors CAKb inhibitor CAKb inhibitors CHK inhibitor CHK inhibitors CSK inhibitor CSK inhibitors CTK inhibitor CTK inhibitors CYL inhibitor CYL inhibitors Cdgip inhibitor Cdgip inhibitors EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitors EC 2.7.10.2 inhibitor EC 2.7.10.2 inhibitors EMT inhibitor EMT inhibitors ETK inhibitor ETK inhibitors FAK inhibitor FAK inhibitors FAK2 inhibitor FAK2 inhibitors FER inhibitor FER inhibitors FES inhibitor FES inhibitors FGR inhibitor FGR inhibitors FPS inhibitor FPS inhibitors FRK inhibitor FRK inhibitors FYN inhibitor FYN inhibitors Fadk inhibitor Fadk inhibitors Fert1/2 inhibitor Fert1/2 inhibitors HCK inhibitor HCK inhibitors HCTK inhibitor HCTK inhibitors HYL inhibitor HYL inhibitors IMD1 inhibitor IMD1 inhibitors ITK inhibitor ITK inhibitors IYK inhibitor IYK inhibitors JAK1 inhibitor JAK1 inhibitors JAK2 inhibitor JAK2 inhibitors JAK3 inhibitor JAK3 inhibitors JTK1 inhibitor JTK1 inhibitors JTK9 inhibitor JTK9 inhibitors Janus kinase 1 inhibitor Janus kinase 1 inhibitors Janus kinase 2 inhibitor Janus kinase 2 inhibitors Janus kinase 3 inhibitor Janus kinase 3 inhibitors Janus kinase inhibitor L-JAK inhibitor L-JAK inhibitors LCK inhibitor LCK inhibitors LSK inhibitor LSK inhibitors LYN inhibitor LYN inhibitors MATK inhibitor MATK inhibitors Ntk inhibitor Ntk inhibitors PKB inhibitor PKB inhibitors PSCTK inhibitor PSCTK inhibitors PSCTK1 inhibitor PSCTK1 inhibitors PSCTK2 inhibitor PSCTK2 inhibitors PSCTK4 inhibitor PSCTK4 inhibitors PSCTK5 inhibitor PSCTK5 inhibitors PTK2 inhibitor PTK2 inhibitors PTK2B inhibitor PTK2B inhibitors PTK6 inhibitor PTK6 inhibitors PYK2 inhibitor PYK2 inhibitors RAFTK inhibitor RAFTK inhibitors RAK inhibitor RAK inhibitors Rlk inhibitor Rlk inhibitors SLK inhibitor SLK inhibitors SRC inhibitor SRC inhibitors SRC2 inhibitor SRC2 inhibitors SRK inhibitor SRK inhibitors SRM inhibitor SRM inhibitors SRMS inhibitor SRMS inhibitors STD inhibitor STD inhibitors SYK inhibitor SYK inhibitors SYN inhibitor SYN inhibitors Sik inhibitor Sik inhibitors TEC inhibitor TEC inhibitors TNK1 inhibitor TNK1 inhibitors TXK inhibitor TXK inhibitors TYK2 inhibitor TYK2 inhibitors TYK3 inhibitor TYK3 inhibitors Tck inhibitor Tck inhibitors Tsk inhibitor Tsk inhibitors YES1 inhibitor YES1 inhibitors YK2 inhibitor YK2 inhibitors ZAP70 inhibitor ZAP70 inhibitors cytoplasmic protein tyrosine kinase inhibitor cytoplasmic protein tyrosine kinase inhibitors focal adhesion kinase inhibitor focal adhesion kinase inhibitors non-specific protein-tyrosine kinase (EC 2.7.10.2) inhibitor non-specific protein-tyrosine kinase (EC 2.7.10.2) inhibitors p60c-src protein tyrosine kinase inhibitor p60c-src protein tyrosine kinase inhibitors EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor fluorescence quencher fluorescence quenchers fluorescence quencher EC 2.1.* (C1-transferase) inhibitor C1-transferase (EC 2.1.*) inhibitor C1-transferase (EC 2.1.*) inhibitors C1-transferase inhibitor C1-transferase inhibitors EC 2.1.* (C1-transferase) inhibitors EC 2.1.* inhibitor EC 2.1.* inhibitors one-carbon-containing group transferase inhibitor one-carbon-containing group transferase inhibitors EC 2.1.* (C1-transferase) inhibitor EC 2.2.* (aldehyde or ketone transferase) inhibitor EC 2.2.* (aldehyde or ketone transferase) inhibitors EC 2.2.* inhibitor EC 2.2.* inhibitors aldehyde or ketone transferase inhibitor aldehyde or ketone transferase inhibitors aldehyde/ketone transferase (EC 2.2.*) inhibitor aldehyde/ketone transferase (EC 2.2.*) inhibitors aldehyde/ketone transferase inhibitor aldehyde/ketone transferase inhibitors EC 2.2.* (aldehyde or ketone transferase) inhibitor EC 2.3.* (acyltransferase) inhibitor EC 2.3.* (acyltransferase) inhibitors EC 2.3.* inhibitor EC 2.3.* inhibitors acyltransferase inhibitor acyltransferase inhibitors EC 2.3.* (acyltransferase) inhibitor EC 2.4.* (glycosyltransferase) inhibitor EC 2.4.* (glycosyltransferase) inhibitors EC 2.4.* inhibitor EC 2.4.* inhibitors glycosyltransferase (EC 2.4.*) inhibitor glycosyltransferase (EC 2.4.*) inhibitors glycosyltransferase inhibitor glycosyltransferase inhibitors EC 2.4.* (glycosyltransferase) inhibitor EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors EC 2.5.1.* inhibitor EC 2.5.1.* inhibitors alkyl/aryl (non-methyl) transferase inhibitor alkyl/aryl (non-methyl) transferase inhibitors non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors non-methyl alkyl/aryl transferase inhibitor non-methyl alkyl/aryl transferase inhibitors non-methyl-alkyl or aryl transferase inhibitor non-methyl-alkyl or aryl transferase inhibitors EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor EC 2.6.* (nitrogenous group transferase) inhibitor EC 2.6.* inhibitor EC 2.6.* inhibitors nitrogenous group transferase (EC 2.6.*) inhibitor nitrogenous group transferase (EC 2.6.*) inhibitors nitrogenous group transferase inhibitor nitrogenous group transferase inhibitors EC 2.6.* (nitrogenous group transferase) inhibitor EC 2.7.* (P-containing group transferase) inhibitor EC 2.7.* (P-containing group transferase) inhibitors EC 2.7.* (phosphorus-containing group transferase) inhibitor EC 2.7.* (phosphorus-containing group transferase) inhibitors EC 2.7.* inhibitor EC 2.7.* inhibitors phosphorus-containing group transferase (EC 2.7.*) inhibitor phosphorus-containing group transferase (EC 2.7.*) inhibitors phosphorus-containing group transferase inhibitor phosphorus-containing group transferase inhibitors EC 2.7.* (P-containing group transferase) inhibitor EC 2.8.* (S-containing group transferase) inhibitor EC 2.8.* (S-containing group transferase) inhibitor EC 2.8.* (S-containing group transferase) inhibitors EC 2.8.* inhibitor EC 2.8.* inhibitors S-containing group transferase inhibitor S-containing group transferase inhibitors sulfur-containing group transferase (EC 2.8.*) inhibitor sulfur-containing group transferase (EC 2.8.*) inhibitors sulfur-containing group transferase inhibitor sulfur-containing group transferase inhibitors EC 2.8.* (S-containing group transferase) inhibitor EC 2.9.* (Se-containing group transferase) inhibitor EC 2.9.* (Se-containing group transferase) inhibitors EC 2.9.* inhibitor EC 2.9.* inhibitors Se-containing group transferase inhibitor Se-containing group transferase inhibitors selenium-containing group transferase (EC 2.9.*) inhibitor selenium-containing group transferase (EC 2.9.*) inhibitors selenium-containing group transferase inhibitor selenium-containing group transferase inhibitors EC 2.9.* (Se-containing group transferase) inhibitor EC 2.10.* (Mo- or W-containing group transferase) inhibitor EC 2.10.* (Mo- or W-containing group transferase) inhibitors EC 2.10.* inhibitor EC 2.10.* inhibitors Mo- or W-containing group transferase (EC 2.10.*) inhibitor Mo- or W-containing group transferase (EC 2.10.*) inhibitors Mo- or W-containing group transferase inhibitor Mo- or W-containing group transferase inhibitors EC 2.10.* (Mo- or W-containing group transferase) inhibitor EC 5.1.* (racemase/epimerase) inhibitor EC 5.1.* (racemase/epimerase) inhibitors EC 5.1.* inhibitor EC 5.1.* inhibitors racemase and epimerase (EC 5.1*) inhibitor racemase and epimerase (EC 5.1*) inhibitors racemase and epimerase inhibitor racemase and epimerase inhibitors racemase/epimerase inhibitor racemase/epimerase inhibitors EC 5.1.* (racemase/epimerase) inhibitor EC 5.2.* (cis-trans-isomerase) inhibitor EC 5.2.* (cis-trans-isomerase) inhibitors EC 5.2.* inhibitor EC 5.2.* inhibitors cis-trans-isomerase (EC5.2.*) inhibitor cis-trans-isomerase (EC5.2.*) inhibitors cis-trans-isomerase inhibitor cis-trans-isomerase inhibitors EC 5.2.* (cis-trans-isomerase) inhibitor EC 5.3.* (intramolecular oxidoreductase) inhibitor EC 5.3.* (intramolecular oxidoreductase) inhibitors intramolecular oxidoreductase (EC 5.3.*) inhibitor intramolecular oxidoreductase (EC 5.3.*) inhibitors intramolecular oxidoreductase inhibitor intramolecular oxidoreductase inhibitors EC 5.3.* (intramolecular oxidoreductase) inhibitor EC 5.4.* (intramolecular transferase) inhibitor EC 5.4.* (intramolecular transferase) inhibitors intramolecular transferase (EC 5.4.*) inhibitor intramolecular transferase (EC 5.4.*) inhibitors intramolecular transferase inhibitor intramolecular transferase inhibitors EC 5.4.* (intramolecular transferase) inhibitor EC 5.5.* (intramolecular lyase) inhibitor EC 5.5.* (intramolecular lyase) inhibitors EC 5.5.* inhibitor EC 5.5.* inhibitors intramolecular lyase inhibitor intramolecular lyase inhibitors EC 5.5.* (intramolecular lyase) inhibitor EC 5.99.* (other isomerases) inhibitor EC 5.99.* (miscellaneous isomerases) inhibitor EC 5.99.* (miscellaneous isomerases) inhibitors EC 5.99.* (other isomerase) inhibitor EC 5.99.* (other isomerase) inhibitors EC 5.99.* (other isomerases) inhibitors EC 5.99.* inhibitor EC 5.99.* inhibitors EC 5.99.* (other isomerases) inhibitor EC 6.1.* (C-O bond-forming ligase) inhibitor C-O bond-forming ligase (EC 6.1.*) inhibitor C-O bond-forming ligase (EC 6.1.*) inhibitors C-O bond-forming ligase inhibitor C-O bond-forming ligase inhibitors EC 6.1.* (C-O bond-forming ligase) inhibitors EC 6.1.* inhibitor EC 6.1.* inhibitors EC 6.1.* (C-O bond-forming ligase) inhibitor EC 6.2.* (C-S bond-forming ligase) inhibitor C-S bond-forming ligase (EC 6.2.*) inhibitor C-S bond-forming ligase (EC 6.2.*) inhibitors C-S bond-forming ligase inhibitor C-S bond-forming ligase inhibitors EC 6.2.* (C-S bond-forming ligase) inhibitors EC 6.2.* inhibitor EC 6.2.* inhibitors EC 6.2.* (C-S bond-forming ligase) inhibitor EC 6.6.* (N-metal bond-forming ligase) inhibitor EC 6.6.* (N-metal bond-forming ligase) inhibitors EC 6.6.* inhibitor EC 6.6.* inhibitors N-metal bond-forming ligase (EC 6.6.*) inhibitor N-metal bond-forming ligase (EC 6.6.*) inhibitors N-metal bond-forming ligase inhibitor N-metal bond-forming ligase inhibitors EC 6.6.* (N-metal bond-forming ligase) inhibitor EC 4.* (lyase) inhibitor EC 4.* (lyase) inhibitors EC 4.* inhibitor EC 4.* inhibitors EC 4.*.*.* inhibitor EC 4.*.*.* inhibitors lyase (EC 4.*) inhibitor lyase (EC 4.*) inhibitorS lyase inhibitor lyase inhibitors EC 4.* (lyase) inhibitor EC 4.1.* (C-C lyase) inhibitor C-C lyase (EC 4.1.*) inhibitor C-C lyase (EC 4.1.*) inhibitors C-C lyase inhibitor C-C lyase inhibitors EC 4.1.* (C-C lyase) inhibitors EC 4.1.* inhibitor EC 4.1.* inhibitors EC 4.1.* (C-C lyase) inhibitor EC 4.2.* (C-O lyase) inhibitor C-O lyase (EC 4.2.*) inhibitor C-O lyase (EC 4.2.*) inhibitors C-O lyase inhibitor C-O lyase inhibitors EC 4.2.* (C-O lyase) inhibitors EC 4.2.* inhibitor EC 4.2.* inhibitors EC 4.2.* (C-O lyase) inhibitor EC 4.3.* (C-N lyase) inhibitor C-N lyase (EC 4.3.*) inhibitor C-N lyase (EC 4.3.*) inhibitors C-N lyase inhibitor C-N lyase inhibitors EC 4.3.* (C-N lyase) inhibitors EC 4.3.* inhibitor EC 4.3.* inhibitors EC 4.3.* (C-N lyase) inhibitor EC 4.4.* (C-S lyase) inhibitor C-S lyase (EC 4.4.*) inhibitor C-S lyase (EC 4.4.*) inhibitors C-S lyase inhibitor C-S lyase inhibitors EC 4.4.* (C-S lyase) inhibitors EC 4.4.* inhibitor EC 4.4.* inhibitors EC 4.4.* (C-S lyase) inhibitor EC 4.5.* (C-halide lyase) inhibitor C-halide lyase (EC 4.5.*) inhibitor C-halide lyase (EC 4.5.*) inhibitors C-halide lyase inhibitor C-halide lyase inhibitors EC 4.5.* (C-halide lyase) inhibitors EC 4.5.* inhibitor EC 4.5.* inhibitors EC 4.5.* (C-halide lyase) inhibitor EC 4.6.* (P-O lyase) inhibitor EC 4.6.* (P-O lyase) inhibitors EC 4.6.* inhibitor EC 4.6.* inhibitors P-O lyase (EC 4.6.*) inhibitor P-O lyase (EC 4.6.*) inhibitors P-O lyase inhibitor P-O lyase inhibitors EC 4.6.* (P-O lyase) inhibitor EC 4.7.* (C-P lyase) inhibitor C-P lyase (EC 4.7.*) inhibitor C-P lyase (EC 4.7.*) inhibitors C-P lyase inhibitor C-P lyase inhibitors EC 4.7.* (C-P lyase) inhibitors EC 4.7.* inhibitor EC 4.7.* inhibitors EC 4.7.* (C-P lyase) inhibitor EC 4.99.* (miscellaneous lyase) inhibitor EC 4.99.* (miscellaneous lyase) inhibitors EC 4.99.* (other lyase) inhibitor EC 4.99.* (other lyase) inhibitors EC 4.99.* inhibitor EC 4.99.* inhibitors miscellaneous lyase (EC 4.99.*) inhibitor miscellaneous lyase (EC 4.99.*) inhibitors miscellaneous lyase inhibitor miscellaneous lyase inhibitors other lyase (EC 4.99.*) inhibitor other lyase (EC 4.99.*) inhibitors EC 4.99.* (miscellaneous lyase) inhibitor antisense oligonucleotide antisense oligonucleotide EC 1.* (oxidoreductase) inhibitor EC 1.* (oxidoreductase) inhibitors EC 1.* inhibitor EC 1.* inhibitors oxidoreductase (EC 1.*) inhibitor oxidoreductase (EC 1.*) inhibitors oxidoreductase inhibitor oxidoreductase inhibitors EC 1.* (oxidoreductase) inhibitor EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors EC 1.1.* inhibitor EC 1.1.* inhibitors inhibitor of oxidoreductase acting on CH-OH group of donor inhibitor of oxidoreductase acting on CH-OH group of donors inhibitors of oxidoreductase acting on CH-OH group of donor inhibitors of oxidoreductase acting on CH-OH group of donors oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors oxidoreductase acting on donor CH-OH group inhibitor oxidoreductase acting on donor CH-OH group inhibitors EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors EC 1.2.* inhibitor EC 1.2.* inhibitors inhibitor of oxidoreductase acting on aldehyde or oxo group of donor inhibitor of oxidoreductase acting on aldehyde or oxo group of donors inhibitor of oxidoreductase acting on aldehyde/oxo group of donor inhibitor of oxidoreductase acting on aldehyde/oxo group of donors inhibitors of oxidoreductase acting on aldehyde or oxo group of donor inhibitors of oxidoreductase acting on aldehyde or oxo group of donors inhibitors of oxidoreductase acting on aldehyde/oxo group of donor inhibitors of oxidoreductase acting on aldehyde/oxo group of donors oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors oxidoreductase acting on donor aldehyde or oxo group inhibitor oxidoreductase acting on donor aldehyde or oxo group inhibitors oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors oxidoreductase acting on donor aldehyde/oxo group inhibitor oxidoreductase acting on donor aldehyde/oxo group inhibitors EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors EC 1.3.* inhibitor EC 1.3.* inhibitors inhibitor of oxidoreductase acting on CH-CH group of donor inhibitor of oxidoreductase acting on CH-CH group of donors inhibitors of oxidoreductase acting on CH-CH group of donor inhibitors of oxidoreductase acting on CH-CH group of donors oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors oxidoreductase acting on donor CH-CH group inhibitor oxidoreductase acting on donor CH-CH group inhibitors EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitors EC 1.4.* inhibitor EC 1.4.* inhibitors inhibitor of oxidoreductase acting on CH-NH2 group of donor inhibitor of oxidoreductase acting on CH-NH2 group of donors inhibitors of oxidoreductase acting on CH-NH2 group of donor inhibitors of oxidoreductase acting on CH-NH2 group of donors oxidoreductase acting on CH-NH2 group of donor inhibitor oxidoreductase acting on CH-NH2 group of donor inhibitors oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitor oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitors EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors EC 1.5.* inhibitor EC 1.5.* inhibitors inhibitor of oxidoreductase acting on CH-NH group of donor inhibitor of oxidoreductase acting on CH-NH group of donors inhibitors of oxidoreductase acting on CH-NH group of donor inhibitors of oxidoreductase acting on CH-NH group of donors oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors inhibitor of oxidoreductase acting on NADH or NADPH inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors of oxidoreductase acting on NADH or NADPH inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*) oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors oxidoreductase acting on NADH or NADPH inhibitor oxidoreductase acting on NADH or NADPH inhibitors EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor EC 1.7.* (oxidoreductase acting on other nitrogenous compounds as donors) inhibitor EC 1.7.* (oxidoreductase acting on other nitrogenous compounds as donors) inhibitors EC 1.7.* inhibitor EC 1.7.* inhibitors inhibitor of oxidoreductase acting on other nitrogenous compounds as donors inhibitor of oxidoreductase acting on other nitrogenous compounds as donors (EC 1.7.*) inhibitors of oxidoreductase acting on other nitrogenous compounds as donors inhibitors of oxidoreductase acting on other nitrogenous compounds as donors (EC 1.7.*) EC 1.7.* (oxidoreductase acting on other nitrogenous compounds as donors) inhibitor EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors EC 1.8.* inhibitor EC 1.8.* inhibitors oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitor EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitors EC 1.9.* (oxidoreductase acting on donor heme group) inhibitors EC 1.9.* inhibitor EC 1.9.* inhibitors oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitor oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitors EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitors EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitor EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitors EC 1.10.* inhibitor EC 1.10.* inhibitors inhibitor of an oxidoreductase acting on diphenols and related substances as donor inhibitor of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*) inhibitor of an oxidoreductase acting on diphenols and related substances as donors inhibitors of an oxidoreductase acting on diphenols and related substances as donor inhibitors of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*) inhibitors of an oxidoreductase acting on diphenols and related substances as donors EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitors EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitor EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitors EC 1.11.* inhibitor EC 1.11.* inhibitors oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitor oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitors oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitor oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitors EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor EC 1.12.* (oxidoreductase acting on hydrogen as donors) inhibitor EC 1.12.* (oxidoreductase acting on hydrogen as donors) inhibitors EC 1.12.* (oxidoreductases acting on hydrogen as donors) inhibitor EC 1.12.* (oxidoreductases acting on hydrogen as donors) inhibitors EC 1.12.* inhibitor EC 1.12.* inhibitors inhibitor of oxidoreductase acting on hydrogen as donors inhibitor of oxidoreductase acting on hydrogen as donors (EC 1.12.*) inhibitors of oxidoreductase acting on hydrogen as donors inhibitors of oxidoreductase acting on hydrogen as donors (EC 1.12.*) oxidoreductase acting on hydrogen as donors inhibitor oxidoreductase acting on hydrogen as donors inhibitors EC 1.12.* (oxidoreductase acting on hydrogen as donors) inhibitor EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors EC 1.13.* inhibitor EC 1.13.* inhibitors oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors EC 1.14.* inhibitor EC 1.14.* inhibitors inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitor EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitors EC 1.15.* inhibitor EC 1.15.* inhibitors inhibitor of oxidoreductase acting on superoxide as acceptor inhibitor of oxidoreductase acting on superoxide as acceptor (EC 1.15.*) inhibitors of oxidoreductase acting on superoxide as acceptor inhibitors of oxidoreductase acting on superoxide as acceptor (EC 1.15.*) oxidoreductase acting on superoxide as acceptor (EC 1.15.*) inhibitor oxidoreductase acting on superoxide as acceptor (EC 1.15.*) inhibitors oxidoreductase acting on superoxide as acceptor inhibitor oxidoreductase acting on superoxide as acceptor inhibitors EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitor EC 1.16.* (oxidoreductase oxidising metal ions) inhibitor EC 1.16.* (oxidoreductase oxidising metal ions) inhibitors EC 1.16.* (oxidoreductase oxidizing metal ions) inhibitor EC 1.16.* (oxidoreductase oxidizing metal ions) inhibitors EC 1.16.* inhibitor EC 1.16.* inhibitors oxidoreductase oxidising metal ions (EC 1.16.*) inhibitor oxidoreductase oxidising metal ions (EC 1.16.*) inhibitors oxidoreductase oxidising metal ions inhibitor oxidoreductase oxidising metal ions inhibitors oxidoreductase oxidizing metal ions (EC 1.16.*) inhibitor oxidoreductase oxidizing metal ions (EC 1.16.*) inhibitors oxidoreductase oxidizing metal ions inhibitor oxidoreductase oxidizing metal ions inhibitors EC 1.16.* (oxidoreductase oxidising metal ions) inhibitor EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors EC 1.17.* inhibitor EC 1.17.* inhibitors oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitor oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitors oxidoreductase acting on CH or CH2 inhibitor oxidoreductase acting on CH or CH2 inhibitors EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor EC 1.18.* (oxidoreductase acting on Fe-S proteins as donors) inhibitor EC 1.18.* (oxidoreductase acting on Fe-S proteins as donors) inhibitors EC 1.18.* (oxidoreductase acting on iron-sulfur proteins as donors) inhibitor EC 1.18.* (oxidoreductase acting on iron-sulfur proteins as donors) inhibitors EC 1.18.* inhibitor EC 1.18.* inhibitors inhibitor of oxidoreductase acting on Fe-S proteins as donors inhibitor of oxidoreductase acting on iron-sulfur proteins as donors inhibitors of oxidoreductase acting on Fe-S proteins as donors inhibitors of oxidoreductase acting on iron-sulfur proteins as donors inhibitors of oxidoreductases acting on iron-sulfur proteins as donors oxidoreductase acting on Fe-S proteins as donors (EC 1.18.*) inhibitor oxidoreductase acting on Fe-S proteins as donors (EC 1.18.*) inhibitors oxidoreductase acting on iron-sulfur proteins as donors (EC 1.18.*) inhibitor oxidoreductase acting on iron-sulfur proteins as donors (EC 1.18.*) inhibitors EC 1.18.* (oxidoreductase acting on Fe-S proteins as donors) inhibitor EC 1.19.* (oxidoreductase acting on reduced flavodoxin as donor) inhibitor EC 1.19.* (oxidoreductase acting on reduced flavodoxin as donor) inhibitors EC 1.19.* inhibitor EC 1.19.* inhibitors inhibitor of oxidoreductase acting on reduced flavodoxin as donor inhibitor of oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*) inhibitors of oxidoreductase acting on reduced flavodoxin as donor inhibitors of oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*) oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*) inhibitor oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*) inhibitors EC 1.19.* (oxidoreductase acting on reduced flavodoxin as donor) inhibitor EC 1.20.* (oxidoreductase acting on P or As in donors) inhibitor EC 1.20.* (oxidoreductase acting on P or As in donors) inhibitors EC 1.20.* (oxidoreductase acting on phosphorus or arsenic in donors) inhibitor EC 1.20.* (oxidoreductase acting on phosphorus or arsenic in donors) inhibitors EC 1.20.* inhibitor EC 1.20.* inhibitors oxidoreductase acting on P or As in donors (EC 1.20.*) inhibitor oxidoreductase acting on P or As in donors (EC 1.20.*) inhibitors oxidoreductase acting on phosphorus or arsenic in donors (EC 1.20.*) inhibitor oxidoreductase acting on phosphorus or arsenic in donors (EC 1.20.*) inhibitors EC 1.20.* (oxidoreductase acting on P or As in donors) inhibitor EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitor EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitors EC 1.21.* inhibitor EC 1.21.* inhibitors oxidoreductase acting on X-H and Y-H to form an X-Y bond (EC 1.21.*) inhibitor oxidoreductase acting on X-H and Y-H to form an X-Y bond (EC 1.21.*) inhibitors oxidoreductase acting on X-H and Y-H to form an X-Y bond inhibitor oxidoreductase acting on X-H and Y-H to form an X-Y bond inhibitors EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitor EC 1.22.* (oxidoreductase acting on halogen in donors) inhibitor EC 1.22.* (oxidoreductase acting on halogen in donors) inhibitors EC 1.22.* inhibitor EC 1.22.* inhibitors inhibitor of oxidoreductase acting on halogen in donors inhibitor of oxidoreductase acting on halogen in donors (EC 1.22.*) inhibitors of oxidoreductase acting on halogen in donors inhibitors of oxidoreductase acting on halogen in donors (EC 1.22.*) oxidoreductase acting on halogen in donors (EC 1.22.*) inhibitor oxidoreductase acting on halogen in donors (EC 1.22.*) inhibitors EC 1.22.* (oxidoreductase acting on halogen in donors) inhibitor EC 1.23.* (oxidoreductase acting on C-O-C group as acceptor) inhibitor EC 1.23.* (oxidoreductase acting on C-O-C group as acceptor) inhibitors EC 1.23.* inhibitor EC 1.23.* inhibitors inhibitor of oxidoreductase acting on C-O-C group as acceptor inhibitor of oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*) inhibitors of oxidoreductase acting on C-O-C group as acceptor inhibitors of oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*) oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*) inhibitor oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*) inhibitors oxidoreductase acting on C-O-C group as acceptor inhibitor oxidoreductase acting on C-O-C group as acceptor inhibitors EC 1.23.* (oxidoreductase acting on C-O-C group as acceptor) inhibitor EC 1.97.* (other oxidoreductase) inhibitor EC 1.97.* (miscellaneous oxidoreductase) inhibitor EC 1.97.* (miscellaneous oxidoreductase) inhibitors EC 1.97.* (other oxidoreductase) inhibitors EC 1.97.* inhibitor EC 1.97.* inhibitors inhibitor of 'other' oxidoreductase (EC 1.97.*) inhibitor of miscellaneous oxidoreductase (EC 1.97.*) inhibitors of 'other' oxidoreductase (EC 1.97.*) inhibitors of miscellaneous oxidoreductase (EC 1.97.*) EC 1.97.* (other oxidoreductase) inhibitor EC 1.98.* (enzymes using H2 as reductant) inhibitor EC 1.98.* (enzymes using H2 as reductant) inhibitors EC 1.98.* inhibitor EC 1.98.* inhibitors inhibitor of enzymes using H2 as reductant (EC 1.98.*) inhibitors of enzymes using H2 as reductant (EC 1.98.*) EC 1.98.* (enzymes using H2 as reductant) inhibitor EC 1.99.* (other oxidoreductases using O2 as oxidant) inhibitor EC 1.99.* (other oxidoreductases using O2 as oxidant) inhibitors EC 1.99.* inhibitor EC 1.99.* inhibitors EC 1.99.* (other oxidoreductases using O2 as oxidant) inhibitor EC 3.* (hydrolase) inhibitor EC 3.* (hydrolase) inhibitors EC 3.* inhibitor EC 3.* inhibitors EC 3.*.*.* inhibitor EC 3.*.*.* inhibitors hydrolase (EC 3.*) inhibitor hydrolase (EC 3.*) inhibitors hydrolase inhibitor hydrolase inhibitors EC 3.* (hydrolase) inhibitor EC 3.1.* (ester hydrolase) inhibitor EC 3.1.* (ester hydrolase) inhibitors EC 3.1.* inhibitor EC 3.1.* inhibitors ester hydrolase (EC 3.1.*) inhibitor ester hydrolase (EC 3.1.*) inhibitors ester hydrolase inhibitor ester hydrolase inhibitors EC 3.1.* (ester hydrolase) inhibitor EC 3.2.* (glycosylase) inhibitor EC 3.2.* (glycosylase) inhibitors EC 3.2.* inhibitor EC 3.2.* inhibitors glycosylase (EC 3.2.*) inhibitor glycosylase (EC 3.2.*) inhibitors glycosylase inhibitor glycosylase inhibitors EC 3.2.* (glycosylase) inhibitor EC 3.3.* (ether hydrolase) inhibitor EC 3.3.* (ether hydrolase) inhibitors EC 3.3.* (hydrolase acting on ether bond) inhibitor EC 3.3.* (hydrolase acting on ether bond) inhibitors EC 3.3.* inhibitor EC 3.3.* inhibitors ether hydrolase (EC 3.3.*) inhibitor ether hydrolase (EC 3.3.*) inhibitors ether hydrolase inhibitor ether hydrolase inhibitors EC 3.3.* (ether hydrolase) inhibitor EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors EC 3.5.* inhibitor EC 3.5.* inhibitors EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor EC 3.7.* (hydrolases acting on C-C bonds) inhibitor EC 3.7.* (hydrolases acting on C-C bonds) inhibitors EC 3.7.* (hydrolases acting on carbon-carbon bonds) inhibitor EC 3.7.* (hydrolases acting on carbon-carbon bonds) inhibitors EC 3.7.* inhibitor EC 3.7.* inhibitors EC 3.7.* (hydrolases acting on C-C bonds) inhibitor EC 3.8.* (hydrolases acting on halide bonds) inhibitor EC 3.8.* (hydrolases acting on halide bonds) inhibitors EC 3.8.* inhibitor EC 3.8.* inhibitors hydrolases acting on halide bonds (EC 3.8.*) inhibitor hydrolases acting on halide bonds (EC 3.8.*) inhibitors inhibitor of hydrolases acting on halide bonds (EC 3.8.*) inhibitors of hydrolases acting on halide bonds (EC 3.8.*) EC 3.8.* (hydrolases acting on halide bonds) inhibitor EC 3.9.* (hydrolases acting on P-N bonds) inhibitor EC 3.9.* (hydrolases acting on P-N bonds) inhibitors EC 3.9.* (hydrolases acting on phosphorus-nitrogen bonds) inhibitor EC 3.9.* (hydrolases acting on phosphorus-nitrogen bonds) inhibitors EC 3.9.* inhibitor EC 3.9.* inhibitors hydrolases acting on P-N bonds (EC 3.9.*) inhibitor hydrolases acting on P-N bonds (EC 3.9.*) inhibitors hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*) inhibitor hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*) inhibitors inhibitor of hydrolases acting on P-N bonds inhibitor of hydrolases acting on P-N bonds (EC 3.9.*) inhibitor of hydrolases acting on phosphorus-nitrogen bonds inhibitor of hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*) inhibitors of hydrolases acting on P-N bonds inhibitors of hydrolases acting on P-N bonds (EC 3.9.*) inhibitors of hydrolases acting on phosphorus-nitrogen bonds inhibitors of hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*) EC 3.9.* (hydrolases acting on P-N bonds) inhibitor EC 3.10.* (hydrolases acting on S-N bonds) inhibitor EC 3.10.* (hydrolases acting on S-N bonds) inhibitors EC 3.10.* (hydrolases acting on sulfur-nitrogen bonds) inhibitor EC 3.10.* (hydrolases acting on sulfur-nitrogen bonds) inhibitors EC 3.10.* inhibitor EC 3.10.* inhibitors hydrolases acting on S-N bonds (EC 3.10.*) inhibitor hydrolases acting on S-N bonds (EC 3.10.*) inhibitors hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*) inhibitor hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*) inhibitors inhibitor of hydrolases acting on S-N bonds inhibitor of hydrolases acting on S-N bonds (EC 3.10.*) inhibitor of hydrolases acting on sulfur-nitrogen bonds inhibitor of hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*) inhibitors of hydrolases acting on S-N bonds inhibitors of hydrolases acting on S-N bonds (EC 3.10.*) inhibitors of hydrolases acting on sulfur-nitrogen bonds inhibitors of hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*) EC 3.10.* (hydrolases acting on S-N bonds) inhibitor EC 3.11.* (hydrolases acting on C-P bonds) inhibitor EC 3.11.* (hydrolases acting on C-P bonds) inhibitors EC 3.11.* (hydrolases acting on carbon-phosphorus bonds) inhibitor EC 3.11.* (hydrolases acting on carbon-phosphorus bonds) inhibitors EC 3.11.* inhibitor EC 3.11.* inhibitors hydrolases acting on C-P bonds (EC 3.11.*) inhibitor hydrolases acting on C-P bonds (EC 3.11.*) inhibitors hydrolases acting on carbon-phosphorus bonds (EC 3.11.*) inhibitor hydrolases acting on carbon-phosphorus bonds (EC 3.11.*) inhibitors inhibitor of hydrolases acting on C-P bonds inhibitor of hydrolases acting on C-P bonds (EC 3.11.*) inhibitor of hydrolases acting on carbon-phosphorus bonds inhibitor of hydrolases acting on carbon-phosphorus bonds (EC 3.11.*) inhibitors of hydrolases acting on C-P bonds inhibitors of hydrolases acting on C-P bonds (EC 3.11.*) inhibitors of hydrolases acting on carbon-phosphorus bonds inhibitors of hydrolases acting on carbon-phosphorus bonds (EC 3.11.*) EC 3.11.* (hydrolases acting on C-P bonds) inhibitor EC 3.12.* (hydrolases acting on S-S bonds) inhibitor EC 3.12.* (hydrolases acting on S-S bonds) inhibitors EC 3.12.* (hydrolases acting on sulfur-sulfur bonds) inhibitor EC 3.12.* (hydrolases acting on sulfur-sulfur bonds) inhibitors EC 3.12.* inhibitor EC 3.12.* inhibitors hydrolases acting on S-S bonds (EC 3.12.*) inhibitor hydrolases acting on S-S bonds (EC 3.12.*) inhibitors hydrolases acting on S-S bonds inhibitor hydrolases acting on S-S bonds inhibitors hydrolases acting on sulfur-sulfur bonds (EC 3.12.*) inhibitor hydrolases acting on sulfur-sulfur bonds (EC 3.12.*) inhibitors hydrolases acting on sulfur-sulfur bonds inhibitor hydrolases acting on sulfur-sulfur bonds inhibitors EC 3.12.* (hydrolases acting on S-S bonds) inhibitor EC 3.13.* (hydrolases acting on C-S bonds) inhibitor EC 3.13.* (hydrolases acting on C-S bonds) inhibitors EC 3.13.* (hydrolases acting on carbon-sulfur bonds) inhibitor EC 3.13.* (hydrolases acting on carbon-sulfur bonds) inhibitors EC 3.13.* inhibitor EC 3.13.* inhibitors hydrolases acting on C-S bonds (EC 3.13.*) inhibitor hydrolases acting on C-S bonds (EC 3.13.*) inhibitors hydrolases acting on C-S bonds inhibitor hydrolases acting on C-S bonds inhibitors hydrolases acting on carbon-sulfur bonds (EC 3.13.*) inhibitor hydrolases acting on carbon-sulfur bonds (EC 3.13.*) inhibitors hydrolases acting on carbon-sulfur bonds inhibitor hydrolases acting on carbon-sulfur bonds inhibitors EC 3.13.* (hydrolases acting on C-S bonds) inhibitor EC 3.1.1.* (carboxylic ester hydrolase) inhibitor EC 3.1.1.* (carboxylic ester hydrolase) inhibitors EC 3.1.1.* inhibitor EC 3.1.1.* inhibitors carboxylic ester hydrolase (EC 3.1.1.*) inhibitor carboxylic ester hydrolase (EC 3.1.1.*) inhibitors EC 3.1.1.* (carboxylic ester hydrolase) inhibitor EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors EC 3.1.3.* inhibitor EC 3.1.3.* inhibitors inhibitor of phosphoric monoester hydrolase inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors of phosphoric monoester hydrolase inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*) phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors phosphoric monoester hydrolase inhibitor phosphoric monoester hydrolase inhibitors EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor EC 3.4.21.26 (prolyl oligopeptidase) inhibitor EC 3.4.21.26 (prolyl oligopeptidase) inhibitors EC 3.4.21.26 inhibitor EC 3.4.21.26 inhibitors endoprolylpeptidase inhibitor endoprolylpeptidase inhibitors post-proline cleaving enzyme inhibitor post-proline cleaving enzyme inhibitors post-proline endopeptidase inhibitor post-proline endopeptidase inhibitors proline endopeptidase inhibitor proline endopeptidase inhibitors proline-specific endopeptidase inhibitor proline-specific endopeptidase inhibitors prolyl endopeptidase inhibitor prolyl endopeptidase inhibitors prolyl oligopeptidase (EC 3.4.21.26) inhibitor prolyl oligopeptidase (EC 3.4.21.26) inhibitors prolyl oligopeptidase inhibitor EC 3.4.21.26 (prolyl oligopeptidase) inhibitor EC 3.4.15.* (peptidyl-dipeptidase) inhibitor EC 3.4.15.* (peptidyl-dipeptidase) inhibitors EC 3.4.15.* inhibitor EC 3.4.15.* inhibitors inhibitor of peptidyl-dipeptidases inhibitor of peptidyl-dipeptidases (EC 3.4.15.*) inhibitors of peptidyl-dipeptidases inhibitors of peptidyl-dipeptidases (EC 3.4.15.*) peptidyl-dipeptidase (EC 3.4.15.*) inhibitor peptidyl-dipeptidase (EC 3.4.15.*) inhibitors peptidyl-dipeptidase inhibitor peptidyl-dipeptidase inhibitors EC 3.4.15.* (peptidyl-dipeptidase) inhibitor EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitors EC 3.1.26.* inhibitor EC 3.1.26.* inhibitors endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitor endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitors endoribonuclease producing 5'-phosphomonoesters inhibitor endoribonuclease producing 5'-phosphomonoesters inhibitors EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor EC 3.4.11.* (aminopeptidase) inhibitor EC 3.4.11.* (aminopeptidase) inhibitors EC 3.4.11.* inhibitor EC 3.4.11.* inhibitors aminopeptidase (EC 3.4.11.*) inhibitor aminopeptidase (EC 3.4.11.*) inhibitors EC 3.4.11.* (aminopeptidase) inhibitor EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitors EC 3.4.14.* inhibitor EC 3.4.14.* inhibitors EC 3.4.14.*(dipeptidyl-peptidases and tripeptidyl-peptidases) inhibitor EC 3.4.14.*(dipeptidyl-peptidases and tripeptidyl-peptidases) inhibitors dipeptidyl- and tripeptidyl-peptidase (EC 3.4.14.*) inhibitor dipeptidyl- and tripeptidyl-peptidase (EC 3.4.14.*) inhibitors dipeptidyl- and tripeptidyl-peptidase inhibitor dipeptidyl- and tripeptidyl-peptidase inhibitors dipeptidyl- and tripeptidyl-peptidases (EC 3.4.14.*) inhibitor dipeptidyl- and tripeptidyl-peptidases (EC 3.4.14.*) inhibitors dipeptidyl- and tripeptidyl-peptidases inhibitor dipeptidyl- and tripeptidyl-peptidases inhibitors dipeptidyl-peptidases and tripeptidyl-peptidases (EC 3.4.14.*) inhibitor dipeptidyl-peptidases and tripeptidyl-peptidases (EC 3.4.14.*) inhibitors EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor EC 2.4.1.* (hexosyltransferase) inhibitor EC 2.4.1.* (hexosyltransferase) inhibitors EC 2.4.1.* inhibitor EC 2.4.1.* inhibitors hexosyltransferase (EC 2.4.1.*) inhibitor hexosyltransferase (EC 2.4.1.*) inhibitors hexosyltransferase inhibitor hexosyltransferase inhibitors EC 2.4.1.* (hexosyltransferase) inhibitor EC 2.4.2.* (pentosyltransferase) inhibitor EC 2.4.2.* (pentosyltransferase) inhibitors EC 2.4.2.* inhibitor EC 2.4.2.* inhibitors pentosyltransferase (EC 2.4.2.*) inhibitor pentosyltransferase (EC 2.4.2.*) inhibitors pentosyltransferase inhibitor pentosyltransferase inhibitors EC 2.4.2.* (pentosyltransferase) inhibitor EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitor EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitors EC 3.1.27.* inhibitor EC 3.1.27.* inhibitors inhibitor of endoribonucleases producing other than 5'-phosphomonoesters inhibitor of endoribonucleases producing other than 5'-phosphomonoesters (EC 3.1.27.*) inhibitors of endoribonucleases producing other than 5'-phosphomonoesters inhibitors of endoribonucleases producing other than 5'-phosphomonoesters (EC 3.1.27.*) EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitor EC 3.4.22.36 (caspase-1) inhibitor EC 3.4.22.36 (caspase-1) inhibitors EC 3.4.22.36 inhibitor EC 3.4.22.36 inhibitors ICE inhibitor ICE inhibitors caspase-1 (EC 3.4.22.36) inhibitor caspase-1 (EC 3.4.22.36) inhibitors caspase-1 inhibitor caspase-1 inhibitors interleukin 1 converting enzyme inhibitor interleukin 1 converting enzyme inhibitors interleukin 1beta converting enzyme inhibitor interleukin 1beta converting enzyme inhibitors interleukin 1beta precursor proteinase inhibitor interleukin 1beta precursor proteinase inhibitors interleukin 1beta-converting endopeptidase inhibitor interleukin 1beta-converting endopeptidase inhibitors interleukin 1beta-converting enzyme inhibitor interleukin 1beta-converting enzyme inhibitors interleukin-1 beta convertase precursor inhibitor interleukin-1 beta convertase precursor inhibitors interleukin-1beta convertase inhibitor interleukin-1beta convertase inhibitors interleukin-1beta converting enzyme inhibitor interleukin-1beta converting enzyme inhibitors interleukin-1beta precursor proteinase inhibitor interleukin-1beta precursor proteinase inhibitors precursor interleukin-1beta converting enzyme inhibitor precursor interleukin-1beta converting enzyme inhibitors pro-interleukin 1beta proteinase inhibitor pro-interleukin 1beta proteinase inhibitors prointerleukin 1beta protease inhibitor prointerleukin 1beta protease inhibitors protease A inhibitor protease A inhibitors protease VII inhibitor protease VII inhibitors EC 3.4.22.36 (caspase-1) inhibitor EC 3.4.22.* (cysteine endopeptidase) inhibitor EC 3.4.22.* (cysteine endopeptidase) inhibitors EC 3.4.22.* inhibitor EC 3.4.22.* inhibitors cysteine endopeptidase (EC 3.4.22.*) inhibitor cysteine endopeptidase (EC 3.4.22.*) inhibitors cysteine endopeptidase inhibitor cysteine endopeptidase inhibitors EC 3.4.22.* (cysteine endopeptidase) inhibitor EC 2.5.1.18 (glutathione transferase) inhibitor EC 2.5.1.18 (glutathione transferase) inhibitors EC 2.5.1.18 inhibitor EC 2.5.1.18 inhibitors RX:glutathione R-transferase inhibitor RX:glutathione R-transferase inhibitors S-(hydroxyalkyl)glutathione lyase inhibitor S-(hydroxyalkyl)glutathione lyase inhibitors glutathione S-alkyl transferase inhibitor glutathione S-alkyl transferase inhibitors glutathione S-alkyltransferase inhibitor glutathione S-alkyltransferase inhibitors glutathione S-aralkyltransferase inhibitor glutathione S-aralkyltransferase inhibitors glutathione S-aryltransferase inhibitor glutathione S-aryltransferase inhibitors glutathione S-transferase inhibitor glutathione S-transferase inhibitors glutathione transferase (EC 2.5.1.18) inhibitor glutathione transferase (EC 2.5.1.18) inhibitors glutathione transferase inhibitor glutathione transferase inhibitors EC 2.5.1.18 (glutathione transferase) inhibitor EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitors EC 1.14.15.4 inhibitor EC 1.14.15.4 inhibitors cytochrome p450 XIB1 inhibitor cytochrome p450 XIB1 inhibitors steroid 11beta-hydroxylase inhibitor steroid 11beta-hydroxylase inhibitors steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitors steroid 11beta-monooxygenase inhibitors steroid 11beta/18-hydroxylase inhibitor steroid 11beta/18-hydroxylase inhibitors steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating) inhibitor steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating) inhibitors EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors EC 3.5.1.* inhibitor EC 3.5.1.* inhibitors non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitors EC 3.5.2.* inhibitor EC 3.5.2.* inhibitors non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitor non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitors non-peptide cyclic amide C-N hydrolase inhibitor non-peptide cyclic amide C-N hydrolase inhibitors EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitors non-peptide cyclic amidine C-N hydrolase (EC 3.5.4.*) inhibitor non-peptide cyclic amidine C-N hydrolase (EC 3.5.4.*) inhibitors non-peptide cyclic amidine C-N hydrolase inhibitor non-peptide cyclic amidine C-N hydrolase inhibitors EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitors EC 3.1.4.12 inhibitor EC 3.1.4.12 inhibitors SMase inhibitor SMase inhibitors acid sphingomyelinase inhibitor acid sphingomyelinase inhibitors neutral sphingomyelinase inhibitor neutral sphingomyelinase inhibitors sphingomyelin cholinephosphohydrolase inhibitor sphingomyelin cholinephosphohydrolase inhibitors sphingomyelin phosphodiesterase (EC 3.1.4.12) inhibitor sphingomyelin phosphodiesterase (EC 3.1.4.12) inhibitors sphingomyelin phosphodiesterase inhibitor sphingomyelin phosphodiesterase inhibitors EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor EC 2.7.11.* (protein-serine/threonine kinase) inhibitor EC 2.7.11.* (protein-serine/threonine kinase) inhibitors EC 2.7.11.* inhibitor EC 2.7.11.* inhibitors protein-serine/threonine kinase (EC 2.7.11.*) inhibitor protein-serine/threonine kinase (EC 2.7.11.*) inhibitors protein-serine/threonine kinase inhibitor protein-serine/threonine kinase inhibitors EC 2.7.11.* (protein-serine/threonine kinase) inhibitor EC 2.7.7.* (nucleotidyltransferase) inhibitor EC 2.7.7.* (nucleotidyltransferase) inhibitors inhibitor of nucleotidyltransferases inhibitor of nucleotidyltransferases (EC 2.7.7.*) inhibitors of nucleotidyltransferases inhibitors of nucleotidyltransferases (EC 2.7.7.*) nucleotidyltransferase (EC 2.7.7.*) inhibitor nucleotidyltransferase (EC 2.7.7.*) inhibitors nucleotidyltransferase inhibitor nucleotidyltransferase inhibitors EC 2.7.7.* (nucleotidyltransferase) inhibitor EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitors EC 2.7.8.* inhibitor EC 2.7.8.* inhibitors EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor EC 2.7.10.* (protein-tyrosine kinase) inhibitor EC 2.7.10.* (protein-tyrosine kinase) inhibitors EC 2.7.10.* inhibitor EC 2.7.10.* inhibitors protein-tyrosine kinase (EC 2.7.10.*) inhibitor protein-tyrosine kinase (EC 2.7.10.*) inhibitors protein-tyrosine kinase inhibitor protein-tyrosine kinase inhibitors EC 2.7.10.* (protein-tyrosine kinase) inhibitor EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitors EC 2.7.3.* inhibitor EC 2.7.3.* inhibitors phosphotransferases with a nitrogenous group as acceptor (EC 2.7.3.*) inhibitor phosphotransferases with a nitrogenous group as acceptor (EC 2.7.3.*) inhibitors EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor EC 3.2.1.31 (beta-glucuronidase) inhibitor EC 3.2.1.31 (beta-glucuronidase) inhibitors EC 3.2.1.31 inhibitor EC 3.2.1.31 inhibitors beta-D-glucuronoside glucuronosohydrolase inhibitor beta-D-glucuronoside glucuronosohydrolase inhibitors beta-glucuronidase (EC 3.2.1.31) inhibitor beta-glucuronidase (EC 3.2.1.31) inhibitors beta-glucuronidase inhibitor beta-glucuronidase inhibitors beta-glucuronide glucuronohydrolase inhibitor beta-glucuronide glucuronohydrolase inhibitors exo-beta-D-glucuronidase inhibitor exo-beta-D-glucuronidase inhibitors glucuronidase inhibitor glucuronidase inhibitors ketodase inhibitor ketodase inhibitors EC 3.2.1.31 (beta-glucuronidase) inhibitor EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors EC 6.3.1.* inhibitor EC 6.3.1.* inhibitors acid-ammonia (or amine) ligase inhibitor acid-ammonia (or amine) ligase inhibitors EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor EC 6.4.1.* (carboxylase) inhibitor EC 6.4.1.* (C-C bond forming ligase) inhibitor EC 6.4.1.* (C-C bond forming ligase) inhibitors EC 6.4.1.* (C-C bond-forming ligase) inhibitors EC 6.4.1.* (carboxylase) inhibitors EC 6.4.1.* inhibitor EC 6.4.1.* inhibitors inhibitor of ligases forming C-C bonds inhibitor of ligases forming C-C bonds (EC 6.4.1.*) inhibitors of ligases forming C-C bonds inhibitors of ligases forming C-C bonds (EC 6.4.1.*) EC 6.4.1.* (carboxylase) inhibitor EC 6.5.1.* (DNA/RNA repair enzymes) inhibitor EC 6.5.1.* (DNA/RNA repair enzymes) inhibitors EC 6.5.1.* inhibitor EC 6.5.1.* inhibitors EC 6.5.1.* (DNA/RNA repair enzymes) inhibitor EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitor EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitors EC 5.1.1.* inhibitor EC 5.1.1.* inhibitors inhibitor of racemases acting on amino acids and derivatives inhibitor of racemases acting on amino acids and derivatives (EC 5.1.1.*) inhibitors of racemases acting on amino acids and derivatives inhibitors of racemases acting on amino acids and derivatives (EC 5.1.1.*) EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitor EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitor EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitors EC 5.4.3.* inhibitor EC 5.4.3.* inhibitors inhibitor of intramolecular transferase transferring amino groups inhibitor of intramolecular transferase transferring amino groups (EC 5.4.3.*) inhibitors of intramolecular transferase transferring amino groups inhibitors of intramolecular transferase transferring amino groups (EC 5.4.3.*) EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitor EC 5.99.1.* (miscellaneous isomerase) inhibitor EC 5.99.1.* (miscellaneous isomerase) inhibitors EC 5.99.1.* inhibitor EC 5.99.1.* inhibitors EC 5.99.1.* (miscellaneous isomerase) inhibitor EC 4.4.1.* (C-S lyase) inhibitor C-S lyase (EC 4.4.1.*) inhibitor C-S lyase (EC 4.4.1.*) inhibitors EC 4.4.1.* (C-S lyase) inhibitors EC 4.4.1.* inhibitor EC 4.4.1.* inhibitors EC 4.4.1.* (C-S lyase) inhibitor EC 4.3.1.* (ammonia-lyase) inhibitor EC 4.3.1.* (ammonia-lyase) inhibitors EC 4.3.1.* (ammonia-lyases) inhibitor EC 4.3.1.* (ammonia-lyases) inhibitors EC 4.3.1.* inhibitor EC 4.3.1.* inhibitors ammonia-lyase (EC 4.3.1.*) inhibitor ammonia-lyase (EC 4.3.1.*) inhibitors ammonia-lyase inhibitor ammonia-lyase inhibitors EC 4.3.1.* (ammonia-lyase) inhibitor EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors EC 2.5.* inhibitor EC 2.5.* inhibitors non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors EC 1.1.1.* inhibitor EC 1.1.1.* inhibitors oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitors EC 1.1.3.* inhibitor EC 1.1.3.* inhibitors oxidoreductase acting on donor CH-OH group, oxygen as acceptor (EC 1.1.3.*) inhibitor oxidoreductase acting on donor CH-OH group, oxygen as acceptor (EC 1.1.3.*) inhibitors EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors EC 1.13.11.* inhibitor EC 1.13.11.* inhibitors oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors EC 1.14.14.* inhibitor EC 1.14.14.* inhibitors oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors EC 1.14.99.* inhibitor EC 1.14.99.* inhibitors miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitor miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitors EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors EC 1.14.13.* inhibitor EC 1.14.13.* inhibitors oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitors EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitor EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitors EC 1.14.15.* inhibitor EC 1.14.15.* inhibitors oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitor oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitors EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitors EC 1.14.18.* inhibitor EC 1.14.18.* inhibitors oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen (EC 1.14.18.*) inhibitor oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen (EC 1.14.18.*) inhibitors EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitors EC 1.14.16.* inhibitor EC 1.14.16.* inhibitors oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen (EC 1.14.16.*) inhibitor oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen (EC 1.14.16.*) inhibitors EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitors EC 1.17.4.* inhibitor EC 1.17.4.* inhibitors oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitor oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitors EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitors EC 1.17.3.* inhibitor EC 1.17.3.* inhibitors oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitor oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitors EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitors EC 1.2.1.* inhibitor EC 1.2.1.* inhibitors oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitor oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitors EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors EC 1.2.3.* inhibitor EC 1.2.3.* inhibitors oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitor EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitors EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitors EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitors EC 1.3.1.* inhibitor EC 1.3.1.* inhibitors oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitor oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitors EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitors EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitors EC 1.3.98.* inhibitor EC 1.3.98.* inhibitors oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitor oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitors EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor EC 1.3.99.* (oxidoreductase acting on donor CH-CH group with other acceptors) inhibitors EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitors EC 1.3.99.* inhibitor EC 1.3.99.* inhibitors oxidoreductase acting on donor CH-CH group with other acceptors (EC 1.3.99.*) inhibitor oxidoreductase acting on donor CH-CH group with other acceptors (EC 1.3.99.*) inhibitors EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitor EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitor EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitors EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitors EC 1.3.3.* inhibitor EC 1.3.3.* inhibitors oxidoreductase acting on donor CH-CH group with oxygen as acceptor (EC 1.3.3.*) inhibitor oxidoreductase acting on donor CH-CH group with oxygen as acceptor (EC 1.3.3.*) inhibitors EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitor EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitors EC 1.4.3.* inhibitor EC 1.4.3.* inhibitors oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitor oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitors EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitor EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitors EC 1.4.4.* inhibitor EC 1.4.4.* inhibitors oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor (EC 1.4.4.*) inhibitor oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor (EC 1.4.4.*) inhibitors EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitor EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors EC 1.5.1.* inhibitor EC 1.5.1.* inhibitors oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors EC 1.6.5.* inhibitor EC 1.6.5.* inhibitors oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitors EC 1.6.3.* inhibitor EC 1.6.3.* inhibitors oxidoreductase acting on NADH or NADPH with oxygen as acceptor (EC 1.6.3.*) inhibitor oxidoreductase acting on NADH or NADPH with oxygen as acceptor (EC 1.6.3.*) inhibitors EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors EC 1.8.1.* inhibitor EC 1.8.1.* inhibitors oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitors EC 1.9.3.* inhibitor EC 1.9.3.* inhibitors oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitor oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitors EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor EC 2.1.1.* (methyltransferases) inhibitor EC 2.1.1.* (methyltransferase) inhibitor EC 2.1.1.* (methyltransferase) inhibitors EC 2.1.1.* (methyltransferases) inhibitors EC 2.1.1.* inhibitor EC 2.1.1.* inhibitors methyltransferase (EC 2.1.1.*) inhibitor methyltransferase (EC 2.1.1.*) inhibitors EC 2.1.1.* (methyltransferases) inhibitor EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitors EC 2.1.2.* inhibitor EC 2.1.2.* inhibitors hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitor hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitors EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor EC 2.2.1.* (transketolase/transaldolase) inhibitor EC 2.2.1.* (transketolase/transaldolase) inhibitors EC 2.2.1.* (transketolases and transaldolases) inhibitor EC 2.2.1.* (transketolases and transaldolases) inhibitors EC 2.2.1.* inhibitor EC 2.2.1.* inhibitors transketolase/transaldolase (EC 2.2.1.*) inhibitor transketolase/transaldolase (EC 2.2.1.*) inhibitors EC 2.2.1.* (transketolase/transaldolase) inhibitor EC 2.3.2.* (aminoacyltransferase) inhibitor EC 2.3.2.* (aminoacyltransferase) inhibitors EC 2.3.2.* inhibitor EC 2.3.2.* inhibitors aminoacyltransferase (EC 2.3.2.*) inhibitor aminoacyltransferase (EC 2.3.2.*) inhibitors EC 2.3.2.* (aminoacyltransferase) inhibitor EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors EC 2.3.1.* inhibitor EC 2.3.1.* inhibitors acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitor acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitors EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor EC 2.6.1.* (transaminase) inhibitor EC 2.6.1.* (transaminase) inhibitors EC 2.6.1.* inhibitor EC 2.6.1.* inhibitors transaminase (EC 2.6.1.*) inhibitor transaminase (EC 2.6.1.*) inhibitors EC 2.6.1.* (transaminase) inhibitor EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitors EC 2.7.1.* inhibitor EC 2.7.1.* inhibitors phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitor phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitor EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitors EC 2.4.99.* inhibitor EC 2.4.99.* inhibitors glycosyltransferases transferring other glycosyl groups (EC 2.4.99.*) inhibitor glycosyltransferases transferring other glycosyl groups (EC 2.4.99.*) inhibitors EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitor EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitor EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitors EC 3.11.1.* inhibitor EC 3.11.1.* inhibitors hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate (EC 3.11.1.*) inhibitor hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate (EC 3.11.1.*) inhibitors EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitor EC 3.4.23.* (aspartic endopeptidase) inhibitor EC 3.4.23.* (aspartic endopeptidase) inhibitors EC 3.4.23.* (aspartic endopeptidases) inhibitor EC 3.4.23.* (aspartic endopeptidases) inhibitors EC 3.4.23.* inhibitor EC 3.4.23.* inhibitors aspartic endopeptidase (EC 3.4.23.*) inhibitor aspartic endopeptidase (EC 3.4.23.*) inhibitors aspartic endopeptidases (EC 3.4.23.*) inhibitor aspartic endopeptidases (EC 3.4.23.*) inhibitors EC 3.4.23.* (aspartic endopeptidase) inhibitor EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitors EC 3.4.11.14 inhibitor EC 3.4.11.14 inhibitors alanine aminopeptidase inhibitor alanine aminopeptidase inhibitors aminopolypeptidase inhibitor aminopolypeptidase inhibitors arylamidase inhibitor arylamidase inhibitors cytosol alanyl aminopeptidase (EC 3.4.11.14) inhibitor cytosol alanyl aminopeptidase (EC 3.4.11.14) inhibitors cytosol alanyl aminopeptidase inhibitor cytosol alanyl aminopeptidase inhibitors cytosol aminopeptidase III inhibitor cytosol aminopeptidase III inhibitors human liver aminopeptidase inhibitor human liver aminopeptidase inhibitors puromycin-sensitive aminopeptidase inhibitor puromycin-sensitive aminopeptidase inhibitors soluble alanyl aminopeptidase inhibitor soluble alanyl aminopeptidase inhibitors thiol-activated aminopeptidase inhibitor thiol-activated aminopeptidase inhibitors EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor DAP II inhibitor DAP II inhibitors EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitors EC 3.4.14.2 inhibitor EC 3.4.14.2 inhibitors carboxytripeptidase inhibitor carboxytripeptidase inhibitors dipeptidyl aminopeptidase II inhibitor dipeptidyl aminopeptidase II inhibitors dipeptidyl arylamidase II inhibitor dipeptidyl arylamidase II inhibitors dipeptidyl peptidase II inhibitor dipeptidyl peptidase II inhibitors dipeptidyl(amino)peptidase II inhibitor dipeptidyl(amino)peptidase II inhibitors dipeptidyl-peptidase II (EC 3.4.14.2) inhibitor dipeptidyl-peptidase II (EC 3.4.14.2) inhibitors dipeptidyl-peptidase II inhibitor dipeptidyl-peptidase II inhibitors dipeptidylarylamidase inhibitor dipeptidylarylamidase inhibitors EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors EC 3.6.3.* inhibitor EC 3.6.3.* inhibitors acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor EC 1.14.14.1 (unspecific monooxygenase) inhibitor EC 1.14.14.1 (unspecific monooxygenase) inhibitors EC 1.14.14.1 inhibitor EC 1.14.14.1 inhibitors aryl hydrocarbon hydroxylase inhibitor aryl hydrocarbon hydroxylase inhibitors aryl-4-monooxygenase inhibitor aryl-4-monooxygenase inhibitors flavoprotein monooxygenase inhibitor flavoprotein monooxygenase inhibitors flavoprotein-linked monooxygenase inhibitor flavoprotein-linked monooxygenase inhibitors microsomal P-450 inhibitor microsomal P-450 inhibitors microsomal monooxygenase inhibitor microsomal monooxygenase inhibitors substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors unspecific monooxygenase (EC 1.14.14.1) inhibitor unspecific monooxygenase (EC 1.14.14.1) inhibitors unspecific monooxygenase inhibitor unspecific monooxygenase inhibitors xenobiotic monooxygenase inhibitor xenobiotic monooxygenase inhibitors EC 1.14.14.1 (unspecific monooxygenase) inhibitor EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitors EC 1.14.11.* (oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors) inhibitor EC 1.14.11.* (oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors) inhibitors EC 1.14.11.* inhibitor EC 1.14.11.* inhibitors oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors (EC 1.14.11.*) inhibitor oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors (EC 1.14.11.*) inhibitors oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (EC 1.14.11.*) inhibitor oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (EC 1.14.11.*) inhibitors EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor EC 4.1.1.* (carboxy-lyase) inhibitor EC 4.1.1.* (carboxy-lyase) inhibitors EC 4.1.1.* inhibitor EC 4.1.1.* inhibitors carboxy-lyase (EC 4.1.1.*) inhibitor carboxy-lyase (EC 4.1.1.*) inhibitors carboxy-lyases (EC 4.1.1.*) inhibitor carboxy-lyases (EC 4.1.1.*) inhibitors EC 4.1.1.* (carboxy-lyase) inhibitor EC 4.2.1.* (hydro-lyases) inhibitor EC 4.2.1.* (hydro-lyase) inhibitor EC 4.2.1.* (hydro-lyase) inhibitors EC 4.2.1.* (hydro-lyases) inhibitors EC 4.2.1.* inhibitor EC 4.2.1.* inhibitors hydro-lyase (EC 4.2.1.*) inhibitor hydro-lyase (EC 4.2.1.*) inhibitors EC 4.2.1.* (hydro-lyases) inhibitor hyperglycemic agent diabetes inducer hyperglycemic agents hyperglycemic agent EC 1.1.3.9 (galactose oxidase) inhibitor D-galactose oxidase inhibitor D-galactose oxidase inhibitors D-galactose:oxygen 6-oxidoreductase inhibitor D-galactose:oxygen 6-oxidoreductase inhibitors EC 1.1.3.9 (galactose oxidase) inhibitors EC 1.1.3.9 inhibitor EC 1.1.3.9 inhibitors beta-galactose oxidase inhibitor beta-galactose oxidase inhibitors galactose oxidase inhibitor galactose oxidase inhibitors EC 1.1.3.9 (galactose oxidase) inhibitor plant metabolite plant metabolites plant secondary metabolites plant metabolite EC 3.4.13.19 (membrane dipeptidase) inhibitor DPH I inhibitors EC 3.4.13.19 (membrane dipeptidase) inhibitors EC 3.4.13.19 inhibitor EC 3.4.13.19 inhibitors MDP inhibitors aminodipeptidase inhibitors dehydropeptidase I (DPH I) inhibitors dehydropeptidase I inhibitors dipeptidase inhibitors dipeptide hydrolase inhibitors dipeptidyl hydrolase inhibitors glycosyl-phosphatidylinositol-anchored renal dipeptidase inhibitors membrane dipeptidase (EC 3.4.13.19) inhibitor membrane dipeptidase (EC 3.4.13.19) inhibitors membrane dipeptidase inhibitor membrane dipeptidase inhibitors microsomal dipeptidase inhibitors nonspecific dipeptidase inhibitors renal dipeptidase inhibitors EC 3.4.13.19 (membrane dipeptidase) inhibitor pathway inhibitor metabolic pathway inhibitor metabolic pathway inhibitors pathway inhibitors pathway inhibitor EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor EC 3.6.4.* (hydrolase acting on ATP; involved in cellular and subcellular movement) inhibitor EC 3.6.4.* (hydrolase acting on ATP; involved in cellular and subcellular movement) inhibitors EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitors EC 3.6.4.* inhibitor EC 3.6.4.* inhibitors hydrolases acting on ATP; involved in cellular and subcellular movement (EC 3.6.4.*) inhibitor hydrolases acting on ATP; involved in cellular and subcellular movement (EC 3.6.4.*) inhibitors EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor ATP phosphohydrolase (polypeptide-polymerising) inhibitor ATP phosphohydrolase (polypeptide-polymerising) inhibitors ATP phosphohydrolase (polypeptide-polymerizing) inhibitor ATP phosphohydrolase (polypeptide-polymerizing) inhibitors EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitors EC 3.6.4.10 inhibitor EC 3.6.4.10 inhibitors molecular chaperone Hsc70 ATPase inhibitor molecular chaperone Hsc70 ATPase inhibitors non-chaperonin molecular chaperone ATPase (EC 3.6.4.10) inhibitor non-chaperonin molecular chaperone ATPase (EC 3.6.4.10) inhibitors EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor EC 3.4.21.4 (trypsin) inhibitor EC 3.4.21.4 (trypsin) inhibitors EC 3.4.21.4 inhibitor EC 3.4.21.4 inhibitors alpha-trypsin inhibitor alpha-trypsin inhibitors beta-trypsin inhibitor beta-trypsin inhibitors cocoonase inhibitor cocoonase inhibitors parenzyme inhibitor parenzyme inhibitors parenzymol inhibitor parenzymol inhibitors pseudotrypsin inhibitor pseudotrypsin inhibitors sperm receptor hydrolase inhibitor sperm receptor hydrolase inhibitors tripcellim inhibitor tripcellim inhibitors trypsin (EC 3.4.21.4) inhibitor trypsin (EC 3.4.21.4) inhibitors trypsin inhibitor trypsin inhibitors tryptar inhibitor tryptar inhibitors tryptase inhibitor tryptase inhibitors trypure inhibitor trypure inhibitors EC 3.4.21.4 (trypsin) inhibitor fungal metabolite fungal metabolites fungal metabolite Aspergillus metabolite Aspergillus metabolites Aspergillus metabolite Chaetomium metabolite Chaetomium metabolites Chaetomium metabolite Penicillium metabolite Penicillium metabolites Penicillium metabolite human xenobiotic metabolite human xenobiotic metabolites human xenobiotic metabolite fungal xenobiotic metabolite fungal xenobiotic metabolites fungal xenobiotic metabolite bacterial metabolite bacterial metabolite Escherichia coli metabolite E.coli metabolite E.coli metabolites Escherichia coli metabolites Escherichia coli metabolite Streptococcus pneumoniae metabolite S. pneumoniae metabolite S. pneumoniae metabolites S. pneumoniae secondary metabolite S. pneumoniae secondary metabolites Streptococcus pneumoniae metabolites Streptococcus pneumoniae secondary metabolites Streptococcus pneumoniae metabolite bacterial xenobiotic metabolite bacterial xenobiotic metabolites bacterial xenobiotic metabolite corticotropin-releasing factor receptor antagonist CRF antagonist CRF antagonists corticotropin-releasing factor receptor antagonists corticotropin-releasing factor receptor antagonist xenoestrogen xenoestrogens xenoestrogen phytoestrogen phytoestrogens phytoestrogen mycoestrogen mycoestrogens mycoestrogen aryl hydrocarbon receptor antagonist AhR antagonist AhR antagonists AhR receptor antagonist AhR receptor antagonists aryl hydrocarbon receptor antagonists aryl hydrocarbon receptor antagonist EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitors EC 1.10.99.* inhibitor EC 1.10.99.* inhibitors oxidoreductases acting on diphenols and related substances as donors, other acceptors (EC 1.10.99.*) inhibitor oxidoreductases acting on diphenols and related substances as donors, other acceptors (EC 1.10.99.*) inhibitors EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase inhibitor 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase inhibitors EC 1.10.99.2 (ribosyldihydronicotinamide dehydrogenase (quinone)) inhibitor EC 1.10.99.2 (ribosyldihydronicotinamide dehydrogenase (quinone)) inhibitors EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitors EC 1.10.99.2 inhibitor EC 1.10.99.2 inhibitors N-ribosyldihydronicotinamide dehydrogenase (quinone) inhibitor N-ribosyldihydronicotinamide dehydrogenase (quinone) inhibitors NAD(P)H:quinone oxidoreductase-2 inhibitor NAD(P)H:quinone oxidoreductase-2 inhibitors NAD(P)H:quinone oxidoreductase2 inhibitor NAD(P)H:quinone oxidoreductase2 inhibitors NQO2 inhibitor NQO2 inhibitors NRH:quinone oxidoreductase 2 inhibitor NRH:quinone oxidoreductase 2 inhibitors QR2 inhibitor QR2 inhibitors quinone reductase 2 inhibitor quinone reductase 2 inhibitors ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) inhibitor ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) inhibitors EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitors EC 2.3.3.* inhibitor EC 2.3.3.* inhibitors acyltransferase converting acyl to alkyl group on transfer (EC 2.3.3.*) inhibitor acyltransferase converting acyl to alkyl group on transfer (EC 2.3.3.*) inhibitors EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor EC 2.3.3.1 [citrate (Si)-synthase] inhibitor (R)-citrate synthase inhibitor (R)-citrate synthase inhibitors EC 2.3.3.1 (citrate (Si)-synthase) inhibitor EC 2.3.3.1 (citrate (Si)-synthase) inhibitors EC 2.3.3.1 [citrate (Si)-synthase] inhibitors EC 2.3.3.1 inhibitor EC 2.3.3.1 inhibitors acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] inhibitor acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] inhibitors citrate (Si)-synthase (EC 2.3.3.1) inhibitor citrate (Si)-synthase (EC 2.3.3.1) inhibitors citrate condensing enzyme inhibitor citrate condensing enzyme inhibitors citrate oxaloacetate-lyase [(pro-3S)-CH2COO->acetyl-CoA] inhibitor citrate oxaloacetate-lyase [(pro-3S)-CH2COO->acetyl-CoA] inhibitors citrate oxaloacetate-lyase, CoA-acetylating inhibitor citrate oxaloacetate-lyase, CoA-acetylating inhibitors citrate synthase inhibitor citrate synthase inhibitors citrate synthetase inhibitor citrate synthetase inhibitors citric synthase inhibitor citric synthase inhibitors citric-condensing enzyme inhibitor citric-condensing enzyme inhibitors citrogenase inhibitor citrogenase inhibitors condensing enzyme inhibitor condensing enzyme inhibitors oxalacetic transacetase inhibitor oxalacetic transacetase inhibitors oxaloacetate transacetase inhibitor oxaloacetate transacetase inhibitors EC 2.3.3.1 [citrate (Si)-synthase] inhibitor EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor 4-nitrophenylphosphatase (EC 3.1.3.41) inhibitor 4-nitrophenylphosphatase (EC 3.1.3.41) inhibitors 4-nitrophenylphosphate phosphohydrolase inhibitor 4-nitrophenylphosphate phosphohydrolase inhibitors EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitors EC 3.1.3.41 inhibitor EC 3.1.3.41 inhibitors Ecto-p-nitrophenyl phosphatase inhibitor Ecto-p-nitrophenyl phosphatase inhibitors K-pNPPase inhibitor K-pNPPase inhibitors NPPase inhibitor NPPase inhibitors PNPPase inhibitor PNPPase inhibitors nitrophenyl phosphatase inhibitor nitrophenyl phosphatase inhibitors p-nitrophenylphosphatase inhibitor p-nitrophenylphosphatase inhibitors p-nitrophenylphosphate phosphohydrolase inhibitor p-nitrophenylphosphate phosphohydrolase inhibitors para-nitrophenyl phosphatase inhibitor para-nitrophenyl phosphatase inhibitors xK-pNPPase inhibitors EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor mucolytic mucolytics mucolytic expectorant expectorants expectorant EC 1.4.7.* (oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor) inhibitor EC 1.4.7.* (oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor) inhibitors EC 1.4.7.* inhibitor EC 1.4.7.* inhibitors inhibitor of oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor inhibitors of oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor (EC 1.4.7.*) inhibitor oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor (EC 1.4.7.*) inhibitors EC 1.4.7.* (oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor) inhibitor EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitors EC 2.5.1.49 inhibitor EC 2.5.1.49 inhibitors O-acetyl-L-homoserine acetate-lyase (adding methanethiol) inhibitor O-acetyl-L-homoserine acetate-lyase (adding methanethiol) inhibitors O-acetyl-L-homoserine sulfhydrolase inhibitor O-acetyl-L-homoserine sulfhydrolase inhibitors O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase inhibitor O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase inhibitors O-acetylhomoserine (thiol)-lyase inhibitor O-acetylhomoserine (thiol)-lyase inhibitors O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) inhibitor O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) inhibitors O-acetylhomoserine aminocarboxypropyltransferase inhibitor O-acetylhomoserine aminocarboxypropyltransferase inhibitors O-acetylhomoserine sulfhydrolase inhibitor O-acetylhomoserine sulfhydrolase inhibitors methionine synthase inhibitor methionine synthase inhibitors EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor (L-SOS)lyase inhibitor (L-SOS)lyase inhibitors EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitors EC 4.3.1.10 inhibitor EC 4.3.1.10 inhibitors L-serine-O-sulfate ammonia-lyase (pyruvate-forming) inhibitor L-serine-O-sulfate ammonia-lyase (pyruvate-forming) inhibitors serine-sulfate ammonia-lyase (EC 4.3.1.10) inhibitor serine-sulfate ammonia-lyase (EC 4.3.1.10) inhibitors serine-sulfate ammonia-lyase inhibitor serine-sulfate ammonia-lyase inhibitors EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitors EC 1.3.5.* inhibitor EC 1.3.5.* inhibitors inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitor oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor (S)-dihydroorotate:(acceptor) oxidoreductase inhibitor (S)-dihydroorotate:(acceptor) oxidoreductase inhibitors (S)-dihydroorotate:acceptor oxidoreductase inhibitor (S)-dihydroorotate:acceptor oxidoreductase inhibitors (S)-dihydroorotate:quinone oxidoreductase inhibitor (S)-dihydroorotate:quinone oxidoreductase inhibitors DHOD inhibitor DHOD inhibitors DHODH inhibitor DHODH inhibitors DHOdehase inhibitor DHOdehase inhibitors EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitor EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitors EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitors EC 1.3.5.2 inhibitor EC 1.3.5.2 inhibitors dihydroorotate:ubiquinone oxidoreductase inhibitor dihydroorotate:ubiquinone oxidoreductase inhibitors EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitors EC 1.10.2.* inhibitor EC 1.10.2.* inhibitors inhibitor of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitors of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitor oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitors EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitors EC 1.10.2.2 inhibitor EC 1.10.2.2 inhibitors inhibitor of quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitors of quinol--cytochrome-c reductase (EC 1.10.2.2) quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitor quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitors EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitor (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitors (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD(+) 15-oxidoreductase inhibitor (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD(+) 15-oxidoreductase inhibitors 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitor 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitors 15-OH-PGDH inhibitor 15-OH-PGDH inhibitors 15-hydroxyprostaglandin dehydrogenase (NAD(+)) (EC 1.1.1.141) inhibitor 15-hydroxyprostaglandin dehydrogenase (NAD(+)) (EC 1.1.1.141) inhibitors 15-hydroxyprostaglandin dehydrogenase (NAD(+)) inhibitor 15-hydroxyprostaglandin dehydrogenase (NAD(+)) inhibitors 15-hydroxyprostaglandin dehydrogenase inhibitor 15-hydroxyprostaglandin dehydrogenase inhibitors 15-hydroxyprostanoic dehydrogenase inhibitor 15-hydroxyprostanoic dehydrogenase inhibitors EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitors EC 1.1.1.141 inhibitor EC 1.1.1.141 inhibitors NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (type I) inhibitor NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (type I) inhibitors NAD-specific 15-hydroxyprostaglandin dehydrogenase inhibitor NAD-specific 15-hydroxyprostaglandin dehydrogenase inhibitors PGDH inhibitor PGDH inhibitors prostaglandin dehydrogenase inhibitor prostaglandin dehydrogenase inhibitors EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitors EC 1.21.3.* inhibitor EC 1.21.3.* inhibitors inhibitor of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor inhibitor of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*) inhibitors of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor inhibitors of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*) oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*) inhibitor oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*) inhibitors EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor EC 1.21.3.3 (reticuline oxidase) inhibitor (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming) inhibitor (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming) inhibitors BBE inhibitor BBE inhibitors EC 1.21.3.3 (reticuline oxidase) inhibitors EC 1.21.3.3 inhibitor EC 1.21.3.3 inhibitors EC 1.5.3.9 inhibitor EC 1.5.3.9 inhibitors berberine bridge enzyme inhibitor berberine bridge enzyme inhibitors berberine-bridge-forming enzyme inhibitor berberine-bridge-forming enzyme inhibitors reticuline oxidase (EC 1.21.3.3) inhibitor reticuline oxidase (EC 1.21.3.3) inhibitors reticuline oxidase inhibitor reticuline oxidase inhibitors tetrahydroprotoberberine synthase inhibitor tetrahydroprotoberberine synthase inhibitors EC 1.21.3.3 (reticuline oxidase) inhibitor EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC 2.1.1.116) inhibitor 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC 2.1.1.116) inhibitors EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitors EC 2.1.1.116 inhibitor EC 2.1.1.116 inhibitors S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase inhibitor S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase inhibitors EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor EC 2.7.11.10 (IkappaB kinase) inhibitor ATP:[IkappaB protein] phosphotransferase ATP:[IkappaB protein] phosphotransferase inhibitor CHUK inhibitor CHUK inhibitors EC 2.7.11.10 (IkappaB kinase) inhibitors EC 2.7.11.10 inhibitor EC 2.7.11.10 inhibitors IKBKA inhibitor IKBKA inhibitors IKBKB inhibitor IKBKB inhibitors IKK inhibitor IKK inhibitors IKK-1 inhibitor IKK-1 inhibitors IKK-2 inhibitor IKK-2 inhibitors IkappaB kinase (EC 2.7.11.10) inhibitor IkappaB kinase (EC 2.7.11.10) inhibitors IkappaB kinase inhibitor IkappaB kinase inhibitors STK12 inhibitor STK12 inhibitors TANK-binding kinase 1 inhibitor TANK-binding kinase 1 inhibitors TBK1 inhibitor TBK1 inhibitors EC 2.7.11.10 (IkappaB kinase) inhibitor EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122) inhibitor (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122) inhibitors (S)-tetrahydroprotoberberine N-methyltransferase inhibitor (S)-tetrahydroprotoberberine N-methyltransferase inhibitors EC 2.1.1.122 ((S)-tetrahydroprotoberberine N-methyltransferase) inhibitor EC 2.1.1.122 ((S)-tetrahydroprotoberberine N-methyltransferase) inhibitors EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitors EC 2.1.1.122 inhibitor EC 2.1.1.122 inhibitors S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase inhibitor S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase inhibitors tetrahydroprotoberberine cis-N-methyltransferase inhibitor tetrahydroprotoberberine cis-N-methyltransferase inhibitors EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitors EC 3.5.5.* inhibitor EC 3.5.5.* inhibitors hydrolase acting on C-N bonds in nitriles (EC 3.5.5.*) inhibitor hydrolase acting on C-N bonds in nitriles (EC 3.5.5.*) inhibitors inhibitor of hydrolases acting on C-N bonds in nitriles inhibitors of hydrolases acting on C-N bonds in nitriles EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor EC 3.5.5.1 (nitrilase) inhibitor EC 3.5.5.1 (nitrilase) inhibitors EC 3.5.5.1 inhibitor EC 3.5.5.1 inhibitors acetonitrilase inhibitor acetonitrilase inhibitors benzonitrilase inhibitor benzonitrilase inhibitors nitrilase (EC 3.5.5.1) inhibitor nitrilase (EC 3.5.5.1) inhibitors nitrile aminohydrolase inhibitor nitrile aminohydrolase inhibitors EC 3.5.5.1 (nitrilase) inhibitor EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitor (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitors 9-keto-prostaglandin E2 reductase inhibitor 9-keto-prostaglandin E2 reductase inhibitors 9-ketoprostaglandin reductase inhibitor 9-ketoprostaglandin reductase inhibitors EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitors EC 1.1.1.189 inhibitor EC 1.1.1.189 inhibitors PGE-9-ketoreductase inhibitor PGE-9-ketoreductase inhibitors PGE2 9-oxoreductase inhibitor PGE2 9-oxoreductase inhibitors PGE2-9-OR inhibitor PGE2-9-OR inhibitors PGE2-9-ketoreductase inhibitor PGE2-9-ketoreductase inhibitors prostaglandin 9-ketoreductase inhibitor prostaglandin 9-ketoreductase inhibitors prostaglandin E 9-ketoreductase inhibitor prostaglandin E 9-ketoreductase inhibitors prostaglandin E2-9-oxoreductase inhibitor prostaglandin E2-9-oxoreductase inhibitors prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitor prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitors reductase, 15-hydroxy-9-oxoprostaglandin inhibitor reductase, 15-hydroxy-9-oxoprostaglandin inhibitors EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor Toll-like receptor 2 agonist TLR 2 agonist TLR 2 agonists TLR-2 agonist TLR-2 agonists Toll-like receptor 2 agonists Toll-like receptor-2 agonist Toll-like receptor-2 agonists Toll-like receptor 2 agonist histological dye biological stain biological stains histological dyes histological stain histological stains histological dye food colouring food coloring food colorings food colourings food colouring EC 2.7.1.33 (pantothenate kinase) inhibitor ATP:(R)-pantothenate 4'-phosphotransferase inhibitor ATP:(R)-pantothenate 4'-phosphotransferase inhibitors ATP:pantothenate 4'-phosphotransferase inhibitor ATP:pantothenate 4'-phosphotransferase inhibitors D-pantothenate kinase inhibitor D-pantothenate kinase inhibitors EC 2.7.1.33 (pantothenate kinase) inhibitors EC 2.7.1.33 inhibitor EC 2.7.1.33 inhibitors pantothenate kinase (EC 2.7.1.33) inhibitor pantothenate kinase (EC 2.7.1.33) inhibitors pantothenate kinase (phosphorylating) inhibitor pantothenate kinase (phosphorylating) inhibitors pantothenic acid kinase inhibitor pantothenic acid kinase inhibitors EC 2.7.1.33 (pantothenate kinase) inhibitor EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitors EC 3.4.24.83 inhibitor EC 3.4.24.83 inhibitors anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitor anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitors lethal toxin inhibitor lethal toxin inhibitors EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor cardioprotective agent cardioprotective agents cardioprotective agent pregnane X receptor agonist PXR agonist PXR agonists pregnane X receptor agonists pregnane X receptor agonist UDP-glucuronosyltransferase activator UDP-glucuronosyltransferase activators UDP-glucuronosyltransferase activator androstane receptor agonist CAR agonist CAR agonists androstane receptor agonists constitutive androstane receptor agonist constitutive androstane receptor agonists androstane receptor agonist EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors EC 1.8.1.12 inhibitor EC 1.8.1.12 inhibitors N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors NADPH2:trypanothione oxidoreductase inhibitor NADPH2:trypanothione oxidoreductase inhibitors NADPH:trypanothione oxidoreductase inhibitor NADPH:trypanothione oxidoreductase inhibitors trypanothione reductase inhibitor trypanothione reductase inhibitors trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors trypanothione:NADP(+) oxidoreductase inhibitor trypanothione:NADP(+) oxidoreductase inhibitors EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor EC 1.1.1.188 (prostaglandin-F synthase) inhibitor (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 11-oxidoreductase inhibitor (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 11-oxidoreductase inhibitors EC 1.1.1.188 (prostaglandin-F synthase) inhibitors EC 1.1.1.188 inhibitor EC 1.1.1.188 inhibitors NADPH-dependent prostaglandin D2 11-keto reductase inhibitor NADPH-dependent prostaglandin D2 11-keto reductase inhibitors PGD2 11-ketoreductase inhibitor PGD2 11-ketoreductase inhibitors PGF synthetase inhibitor PGF synthetase inhibitors PGF2alpha synthetase inhibitor PGF2alpha synthetase inhibitors prostaglandin 11-keto reductase inhibitor prostaglandin 11-keto reductase inhibitors prostaglandin 11-ketoreductase inhibitor prostaglandin 11-ketoreductase inhibitors prostaglandin D2-ketoreductase inhibitor prostaglandin D2-ketoreductase inhibitors prostaglandin F synthase inhibitor prostaglandin F synthase inhibitors prostaglandin F synthetase inhibitor prostaglandin F synthetase inhibitors prostaglandin-D2 11-reductase inhibitor prostaglandin-D2 11-reductase inhibitors reductase, 15-hydroxy-11-oxoprostaglandin inhibitor reductase, 15-hydroxy-11-oxoprostaglandin inhibitors synthetase, prostaglandin F2alpha inhibitor synthetase, prostaglandin F2alpha inhibitors EC 1.1.1.188 (prostaglandin-F synthase) inhibitor EC 1.1.1.25 (shikimate dehydrogenase) inhibitor 5-dehydroshikimate reductase inhibitor 5-dehydroshikimate reductase inhibitors 5-dehydroshikimic reductase inhibitor 5-dehydroshikimic reductase inhibitors AroE inhibitor AroE inhibitors DHS reductase inhibitor DHS reductase inhibitors EC 1.1.1.25 (shikimate dehydrogenase) inhibitors EC 1.1.1.25 inhibitor EC 1.1.1.25 inhibitors dehydroshikimic reductase inhibitor dehydroshikimic reductase inhibitors shikimate 5-dehydrogenase inhibitor shikimate 5-dehydrogenase inhibitors shikimate dehydrogenase (EC 1.1.1.25) inhibitor shikimate dehydrogenase (EC 1.1.1.25) inhibitors shikimate dehydrogenase inhibitor shikimate dehydrogenase inhibitors shikimate oxidoreductase inhibitor shikimate oxidoreductase inhibitors shikimate:NADP(+) 3-oxidoreductase inhibitor shikimate:NADP(+) 3-oxidoreductase inhibitors shikimate:NADP(+) 5-oxidoreductase inhibitor shikimate:NADP(+) 5-oxidoreductase inhibitors shikimate:NADP(+) oxidoreductase inhibitor shikimate:NADP(+) oxidoreductase inhibitors EC 1.1.1.25 (shikimate dehydrogenase) inhibitor bradykinin receptor agonist bradykinin receptor agonists bradykinin receptor agonist bradykinin receptor B2 agonist B2 receptor agonist B2 receptor agonists B2R agonist B2R agonists bradykinin receptor B2 agonists bradykinin receptor B2 agonist thermal degradation product thermal artefact thermal artefacts thermal degradation products thermal degradation product Maillard reaction product Maillard product Maillard products maillard reaction products Maillard reaction product eugeroic eugeroics vigilance promoting agent vigilance promoting agents vigilance promoting drug vigilance promoting drugs vigilance-promoting agent vigilance-promoting agents vigilance-promoting drug vigilance-promoting drugs wake-promoting agent wake-promoting agents wake-promoting drug wake-promoting drugs wakefulness-promoting agent wakefulness-promoting agents wakefulness-promoting drug wakefulness-promoting drugs eugeroic loop diuretic loop diuretics loop diuretic EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor 1-deoxy-D-xylulose-5-phosphate isomeroreductase inhibitor 1-deoxy-D-xylulose-5-phosphate isomeroreductase inhibitors 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267) inhibitor 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267) inhibitors 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitor 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors 1-deoxyxylulose-5-phosphate reductoisomerase inhibitor 1-deoxyxylulose-5-phosphate reductoisomerase inhibitors 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerising) inhibitor 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerising) inhibitors 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerizing) inhibitor 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerizing) inhibitors 2C-methyl-D-erythritol-4-phosphate (MEP) synthase inhibitor 2C-methyl-D-erythritol-4-phosphate (MEP) synthase inhibitors DXP-reductoisomerase inhibitor DXP-reductoisomerase inhibitors EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitors EC 1.1.1.267 inhibitor EC 1.1.1.267 inhibitors EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor EC 4.3.1.3 (histidine ammonia-lyase) inhibitor EC 4.3.1.3 (histidine ammonia-lyase) inhibitors EC 4.3.1.3 inhibitor EC 4.3.1.3 inhibitors L-histidine ammonia-lyase (urocanate-forming) inhibitor L-histidine ammonia-lyase (urocanate-forming) inhibitors L-histidine ammonia-lyase inhibitor L-histidine ammonia-lyase inhibitors histidase inhibitor histidase inhibitors histidinase inhibitor histidinase inhibitors histidine alpha-deaminase inhibitor histidine alpha-deaminase inhibitors histidine ammonia-lyase (EC 4.3.1.3) inhibitor histidine ammonia-lyase (EC 4.3.1.3) inhibitors histidine ammonia-lyase inhibitor histidine ammonia-lyase inhibitors EC 4.3.1.3 (histidine ammonia-lyase) inhibitor EC 3.4.19.* (omega-peptidase) inhibitor EC 3.4.19.* (omega-peptidase) inhibitors EC 3.4.19.* inhibitor EC 3.4.19.* inhibitors omega-peptidase (EC 3.4.19.*) inhibitor omega-peptidase (EC 3.4.19.*) inhibitors omega-peptidase inhibitor omega-peptidase inhibitors EC 3.4.19.* (omega-peptidase) inhibitor EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor 5-oxoprolyl-peptidase inhibitors EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitors EC 3.4.19.3 inhibitor EC 3.4.19.3 inhibitors L-pyroglutamyl peptide hydrolase inhibitor L-pyroglutamyl peptide hydrolase inhibitors L-pyrrolidonecarboxylate peptidase inhibitor L-pyrrolidonecarboxylate peptidase inhibitors pyrase inhibitor pyrase inhibitors pyroglutamate aminopeptidase inhibitor pyroglutamate aminopeptidase inhibitors pyroglutamidase inhibitor pyroglutamidase inhibitors pyroglutamyl aminopeptidase inhibitor pyroglutamyl aminopeptidase inhibitors pyroglutamyl-peptidase I (EC 3.4.19.3) inhibitor pyroglutamyl-peptidase I (EC 3.4.19.3) inhibitors pyroglutamyl-peptidase I inhibitor pyroglutamyl-peptidase I inhibitors pyrrolidone-carboxyl peptidase inhibitor pyrrolidone-carboxyl peptidase inhibitors pyrrolidonecarboxylyl peptidase inhibitor pyrrolidonecarboxylyl peptidase inhibitors pyrrolidonyl peptidase inhibitor pyrrolidonyl peptidase inhibitors5-oxoprolyl-peptidase inhibitor EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor nasal decongestant decongestant decongestants nasal decongestants nasal decongestant p53 activator cellular tumor antigen p53 activator cellular tumor antigen p53 activators p53 activators phosphoprotein p53 activator phosphoprotein p53 activators tumor protein p53 activator tumor protein p53 activators tumour protein p53 activator tumour protein p53 activators tumour suppressor p53 activator tumour suppressor p53 activators p53 activator EC 3.4.24.18 (meprin A) inhibitor EC 3.4.24.18 (meprin A) inhibitors EC 3.4.24.18 inhibitor EC 3.4.24.18 inhibitors N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitor N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitors PABA-peptide hydrolase inhibitor PABA-peptide hydrolase inhibitors PPH inhibitor PPH inhibitors endopeptidase-2 inhibitor endopeptidase-2 inhibitors meprin A (EC 3.4.24.18) inhibitor meprin A (EC 3.4.24.18) inhibitors meprin A inhibitor meprin A inhibitors meprin inhibitor meprin inhibitors meprin-a inhibitor meprin-a inhibitors EC 3.4.24.18 (meprin A) inhibitor human metabolite H. sapiens metabolite H. sapiens metabolites Homo sapiens metabolite Homo sapiens metabolites human metabolite EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor ATP phosphohydrolase (phospholipid-flipping) inhibitor ATP phosphohydrolase (phospholipid-flipping) inhibitors EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitors EC 3.6.3.1 inhibitor EC 3.6.3.1 inhibitors Mg(2)(+)-ATPase inhibitor Mg(2)(+)-ATPase inhibitors aminophospholipid-transporting ATPase inhibitor aminophospholipid-transporting ATPase inhibitors flippase inhibitor flippase inhibitors magnesium-ATPase inhibitor magnesium-ATPase inhibitors phospholipid-translocating ATPase (EC 3.6.3.1) inhibitor phospholipid-translocating ATPase (EC 3.6.3.1) inhibitors phospholipid-translocating ATPase inhibitor phospholipid-translocating ATPase inhibitors phospholipid-transporting ATPase inhibitor phospholipid-transporting ATPase inhibitors EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor ATP phosphohydrolase (steroid-exporting) inhibitor ATP phosphohydrolase (steroid-exporting) inhibitors ATP phosphohydrolase (xenobiotic-exporting) inhibitor ATP phosphohydrolase (xenobiotic-exporting) inhibitors EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitors EC 3.6.3.44 inhibitor EC 3.6.3.44 inhibitors MDR protein inhibitor MDR protein inhibitors P-glycoprotein inhibitor P-glycoprotein inhibitors PDR protein inhibitor PDR protein inhibitors multidrug-resistance protein inhibitor multidrug-resistance protein inhibitors pleiotropic-drug-resistance protein inhibitor pleiotropic-drug-resistance protein inhibitors steroid-transporting ATPase inhibitor steroid-transporting ATPase inhibitors xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitors xenobiotic-transporting ATPase inhibitor xenobiotic-transporting ATPase inhibitors EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor ATP/ADP translocase inhibitor ATP-ADP translocase inhibitor ATP-ADP translocase inhibitors ATP/ADP translocase inhibitors ATP/ADP translocase inhibitor EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitor 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitors 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitor 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitors 3',5'-cyclic-AMP phosphodiesterase inhibitor 3',5'-cyclic-AMP phosphodiesterase inhibitors EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitors EC 3.1.4.53 inhibitor EC 3.1.4.53 inhibitors cAMP-specific PDE inhibitor cAMP-specific PDE inhibitors cAMP-specific phosphodiesterase inhibitor cAMP-specific phosphodiesterase inhibitors EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor 1-pyrroline dehydrogenase inhibitor 1-pyrroline dehydrogenase inhibitors 1-pyrroline-5-carboxylate dehydrogenase inhibitor 1-pyrroline-5-carboxylate dehydrogenase inhibitors 1-pyrroline-5-carboxylate:NAD(+) oxidoreductase inhibitor 1-pyrroline-5-carboxylate:NAD(+) oxidoreductase inhibitors Delta(1)-pyrroline-5-carboxylate dehydrogenase inhibitor Delta(1)-pyrroline-5-carboxylate dehydrogenase inhibitors Delta(1)-pyrroline-5-carboxylic acid dehydrogenase inhibitor Delta(1)-pyrroline-5-carboxylic acid dehydrogenase inhibitors EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitors EC 1.2.1.88 inhibitor EC 1.2.1.88 inhibitors L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) inhibitor L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) inhibitors L-glutamate gamma-semialdehyde dehydrogenase inhibitor L-glutamate gamma-semialdehyde dehydrogenase inhibitors L-glutamate gamma-semialdehyde:NAD(+) oxidoreductase inhibitor L-glutamate gamma-semialdehyde:NAD(+) oxidoreductase inhibitors L-pyrroline-5-carboxylate-NAD(+) oxidoreductase inhibitor L-pyrroline-5-carboxylate-NAD(+) oxidoreductase inhibitors pyrroline-5-carboxylate dehydrogenase inhibitor pyrroline-5-carboxylate dehydrogenase inhibitors pyrroline-5-carboxylic acid dehydrogenase inhibitor pyrroline-5-carboxylic acid dehydrogenase inhibitors EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor sulfaphenazole 1-phenyl-5-sulfanilamidopyrazole 3-(p-aminobenzenesulfonamido)-2-phenylpyrazole 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide 5-sulfanilamido-1-phenylpyrazole N'-(1-phenylpyrazol-5-yl)sulfanilamide N(1)-(1-phenylpyrazol-5-yl)sulfanilamide Sulfabid sulfafenazol sulfaphenazol sulfaphenazole sulfaphenazolum sulphaphenazole sulfaphenazole EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor 13-deoxydaunorubicin hydroxylase (EC 1.14.13.181) inhibitor 13-deoxydaunorubicin hydroxylase (EC 1.14.13.181) inhibitors 13-deoxydaunorubicin hydroxylase inhibitor 13-deoxydaunorubicin hydroxylase inhibitors 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating) inhibitor 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating) inhibitors DoxA inhibitor DoxA inhibitors EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitors EC 1.14.13.181 inhibitor EC 1.14.13.181 inhibitors EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor EC 1.14.13.67 (quinine 3-monooxygenase) inhibitors EC 1.14.13.67 inhibitor EC 1.14.13.67 inhibitors quinine 3-hydroxylase inhibitor quinine 3-hydroxylase inhibitors quinine 3-monooxygenase (EC 1.14.13.67) inhibitor quinine 3-monooxygenase (EC 1.14.13.67) inhibitors quinine 3-monooxygenase inhibitor quinine 3-monooxygenase inhibitors quinine,NADPH:oxygen oxidoreductase inhibitor quinine,NADPH:oxygen oxidoreductase inhibitors EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor persistent organic pollutant POP POPs persistent organic pollutants persistent organic pollutant EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor 2,3-diaminopropanoate ammonia-lyase (adding H2O; pyruvate-forming) inhibitor 2,3-diaminopropanoate ammonia-lyase (adding H2O; pyruvate-forming) inhibitors 2,3-diaminopropanoate ammonia-lyase (adding water; pyruvate-forming) inhibitor 2,3-diaminopropanoate ammonia-lyase (adding water; pyruvate-forming) inhibitors 2,3-diaminopropanoate ammonia-lyase inhibitor 2,3-diaminopropanoate ammonia-lyase inhibitors 2,3-diaminopropionate ammonia-lyase inhibitor 2,3-diaminopropionate ammonia-lyase inhibitors EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitors EC 4.3.1.15 inhibitor EC 4.3.1.15 inhibitors alpha,beta-diaminopropionate ammonia-lyase inhibitor alpha,beta-diaminopropionate ammonia-lyase inhibitors diaminopropionatase inhibitor diaminopropionatase inhibitors diaminopropionate ammonia-lyase (EC 4.3.1.15) inhibitor diaminopropionate ammonia-lyase (EC 4.3.1.15) inhibitors diaminopropionate ammonia-lyase inhibitor diaminopropionate ammonia-lyase inhibitors EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitors EC 1.14.13.70 inhibitor EC 1.14.13.70 inhibitors cytochrome P450 51 inhibitor cytochrome P450 51 inhibitors lanosterol 14-demethylase inhibitor lanosterol 14-demethylase inhibitors lanosterol 14alpha-demethylase inhibitor lanosterol 14alpha-demethylase inhibitors obtusufoliol 14-demethylase inhibitor obtusufoliol 14-demethylase inhibitors sterol 14-demethylase inhibitor sterol 14-demethylase inhibitors sterol 14alpha-demethylase inhibitor sterol 14alpha-demethylase inhibitors sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitor sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitors EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor EC 3.5.1.4 (amidase) inhibitor EC 3.5.1.4 (amidase) inhibitors EC 3.5.1.4 inhibitor EC 3.5.1.4 inhibitors N-acetylaminohydrolase inhibitor N-acetylaminohydrolase inhibitors acylamidase inhibitor acylamidase inhibitors acylamide amidohydrolase inhibitor acylamide amidohydrolase inhibitors amidase (EC 3.5.1.4) inhibitor amidase (EC 3.5.1.4) inhibitors amidase inhibitor amidase inhibitors amidohydrolase inhibitor amidohydrolase inhibitors deaminase inhibitor deaminase inhibitors fatty acylamidase inhibitor fatty acylamidase inhibitors EC 3.5.1.4 (amidase) inhibitor EC 6.1.1.4 (leucine--tRNA ligase) inhibitor EC 6.1.1.4 (leucine--tRNA ligase) inhibitors EC 6.1.1.4 inhibitor EC 6.1.1.4 inhibitors L-leucine:tRNA(Leu) ligase (AMP-forming) inhibitor L-leucine:tRNA(Leu) ligase (AMP-forming) inhibitors leucine translase inhibitor leucine translase inhibitors leucine--tRNA ligase inhibitor leucine--tRNA ligase inhibitors leucine--tRNA synthetase inhibitor leucine--tRNA synthetase inhibitors leucyl--tRNA synthetase inhibitor leucyl--tRNA synthetase inhibitors leucyl-transfer RNA synthetase inhibitor leucyl-transfer RNA synthetase inhibitors leucyl-transfer ribonucleate synthetase inhibitor leucyl-transfer ribonucleate synthetase inhibitors leucyl-transfer ribonucleic acid synthetase inhibitor leucyl-transfer ribonucleic acid synthetase inhibitors EC 6.1.1.4 (leucine--tRNA ligase) inhibitor food firming agent firming agent firming agents food firming agents food firming agent food antioxidant food antioxidants food antioxidant sequestrant sequestrants sequestrant anticaking agent anti-caking agent anti-caking agents anticaking agents anticaking agent food anticaking agent food anti-caking agent food anti-caking agents food anticaking agent food anticaking agent food stabiliser food stabilisers food stabilizer food stabilizers stabiliser stabilisers stabilizer stabilizers food stabiliser humectant humectants humectant food humectant food humectants food humectant food thickening agent food thickening agents thickening agent thickening agents food thickening agent raising agent food raising agent food raising agents leavening agent leavening agents raising agents raising agent food glazing agent food glazing agents glazing agent glazing agents food glazing agent antifoaming agent antifoaming agents defoamer defoamers antifoaming agent food packaging gas food packaging gases food packaging gas food bleaching agent food bleaching agents food bleaching agent food bulking agent filler fillers food bulking agents food bulking agent food colour retention agent color retention agent color retention agents colour retention agent colour retention agents food color retention agent food color retention agents food colour retention agents food colour retention agent foaming agent foaming agents foaming agent Wiskott-Aldrich syndrome protein inhibitor N-WASP inhibitor N-WASP inhibitors WASP inhibitor WASP inhibitors Wiskott-Aldrich syndrome protein inhibitors Wiskott-Aldrich syndrome protein inhibitor food gelling agent food gelling agents food gelling agent food propellant food propellants food propellant EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitors EC 4.1.1.50 inhibitor EC 4.1.1.50 inhibitors S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] inhibitor S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] inhibitors S-adenosyl-L-methionine carboxy-lyase [S-adenosyl 3-(methylthio)propylamine-forming] inhibitor S-adenosyl-L-methionine carboxy-lyase [S-adenosyl 3-(methylthio)propylamine-forming] inhibitors S-adenosyl-L-methionine carboxy-lyase inhibitor S-adenosyl-L-methionine carboxy-lyase inhibitors S-adenosyl-L-methionine decarboxylase inhibitor S-adenosyl-L-methionine decarboxylase inhibitors S-adenosylmethionine decarboxylase inhibitor S-adenosylmethionine decarboxylase inhibitors EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor Wnt signalling inhibitor Wnt signaling inhibitor Wnt signaling inhibitors Wnt signalling inhibitors Wnt-signaling inhibitor Wnt-signaling inhibitors Wnt-signalling inhibitor Wnt-signalling inhibitors Wnt signalling inhibitor food antifoaming agent food antifoaming agents food defoamer food defoamers food antifoaming agent food additive carrier carrier carriers food additive carriers food additive carrier enzyme mimic enzyme mimetic enzyme mimetics enzyme mimics enzyme mimic oxazepam (+-)-Oxazepam (RS)-Oxazepam 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Oxazepam Serax Tazepam oxazepam vitamin B1 antagonist vitamin B1 antagonists vitamin B1 antagonist food component dietary component dietary components food components food component environmental contaminant environmental contaminants environmental contaminant environmental food contaminant environmental food contaminants environmental food contaminant lichen metabolite lichen metabolites lichen metabolite EC 2.7.1.1 (hexokinase) inhibitor ATP-dependent hexokinase inhibitor ATP-dependent hexokinase inhibitors ATP:D-hexose 6-phosphotransferase inhibitor ATP:D-hexose 6-phosphotransferase inhibitors EC 2.7.1.1 (hexokinase) inhibitors EC 2.7.1.1 inhibitor EC 2.7.1.1 inhibitors glucose ATP phosphotransferase inhibitor glucose ATP phosphotransferase inhibitors hexokinase (phosphorylating) inhibitor hexokinase (phosphorylating) inhibitors hexokinase D inhibitor hexokinase D inhibitors hexokinase inhibitor hexokinase inhibitors hexokinase type I inhibitor hexokinase type I inhibitors hexokinase type II inhibitor hexokinase type II inhibitors hexokinase type III inhibitor hexokinase type III inhibitors hexokinase type IV glucokinase inhibitor hexokinase type IV glucokinase inhibitors hexokinase type IV inhibitor hexokinase type IV inhibitors EC 2.7.1.1 (hexokinase) inhibitor EC 3.1.1.5 (lysophospholipase) inhibitor 2-lysophosphatidylcholine acylhydrolase inhibitor 2-lysophosphatidylcholine acylhydrolase inhibitors EC 3.1.1.5 (lysophospholipase) inhibitors EC 3.1.1.5 inhibitor EC 3.1.1.5 inhibitors NTE inhibitor NTE inhibitors NTE-LysoPLA inhibitor NTE-LysoPLA inhibitors NTE-lysophospholipase inhibitor NTE-lysophospholipase inhibitors lecithinase B inhibitor lecithinase B inhibitors lecitholipase inhibitor lecitholipase inhibitors lysolecithinase inhibitor lysolecithinase inhibitors lysophopholipase L2 inhibitor lysophopholipase L2 inhibitors lysophosphatidase inhibitor lysophosphatidase inhibitors lysophosphatidylcholine hydrolase inhibitor lysophosphatidylcholine hydrolase inhibitors lysophospholipase (EC 3.1.1.5) inhibitor lysophospholipase (EC 3.1.1.5) inhibitors lysophospholipase A1 inhibitor lysophospholipase A1 inhibitors lysophospholipase inhibitor lysophospholipase inhibitors lysophospholipase transacylase inhibitor lysophospholipase transacylase inhibitors neuropathy target esterase inhibitor neuropathy target esterase inhibitors phosphatidase B inhibitor phosphatidase B inhibitors phospholipase B inhibitor phospholipase B inhibitors EC 3.1.1.5 (lysophospholipase) inhibitor EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor 2-enoyl-CoA reductase inhibitor 2-enoyl-CoA reductase inhibitors EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitors EC 1.3.1.8 inhibitor EC 1.3.1.8 inhibitors acyl-CoA dehydrogenase (NADP(+)) (EC 1.3.1.8) inhibitor acyl-CoA dehydrogenase (NADP(+)) (EC 1.3.1.8) inhibitors acyl-CoA dehydrogenase (NADP(+)) inhibitor acyl-CoA dehydrogenase (NADP(+)) inhibitors acyl-CoA:NADP(+) 2-oxidoreductase inhibitor acyl-CoA:NADP(+) 2-oxidoreductase inhibitors crotonyl coenzyme A reductase inhibitor crotonyl coenzyme A reductase inhibitors crotonyl-CoA reductase inhibitor crotonyl-CoA reductase inhibitors dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate) inhibitor dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate) inhibitors enoyl coenzyme A reductase inhibitor enoyl coenzyme A reductase inhibitors EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitors EC 2.5.1.7 inhibitor EC 2.5.1.7 inhibitors MurA transferase inhibitor MurA transferase inhibitors UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitor UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitors UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitor UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitors UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitor UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitors UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitor UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitors enoylpyruvate transferase inhibitor enoylpyruvate transferase inhibitors phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitor phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitors phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitor phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitors phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitor phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitors phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitor phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitors phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitor phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitors phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitor phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitors phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitor phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitors pyruvate-UDP-acetylglucosamine transferase inhibitor pyruvate-UDP-acetylglucosamine transferase inhibitors pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitor pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitors pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitor pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitors pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitor pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitors EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor EC 3.5.4.1 (cytosine deaminase) inhibitor EC 3.5.4.1 (cytosine deaminase) inhibitors EC 3.5.4.1 inhibitor EC 3.5.4.1 inhibitors cytosine aminohydrolase inhibitor cytosine aminohydrolase inhibitors cytosine deaminase (EC 3.5.4.1) inhibitor cytosine deaminase (EC 3.5.4.1) inhibitors cytosine deaminase inhibitor cytosine deaminase inhibitors isocytosine deaminase inhibitor isocytosine deaminase inhibitors EC 3.5.4.1 (cytosine deaminase) inhibitor EC 5.1.2.* (racemases acting on hydroxy acids and derivatives) inhibitor EC 5.1.2.* (racemases acting on hydroxy acids and derivatives) inhibitors EC 5.1.2.* inhibitor EC 5.1.2.* inhibitors inhibitor of racemases acting on hydroxy acids and derivatives inhibitor of racemases acting on hydroxy acids and derivatives (EC 5.1.2.*) inhibitors of racemases acting on hydroxy acids and derivatives inhibitors of racemases acting on hydroxy acids and derivatives (EC 5.1.2.*) EC 5.1.2.* (racemases acting on hydroxy acids and derivatives) inhibitor EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitors EC 5.1.3.* inhibitor EC 5.1.3.* inhibitors inhibitor of racemases acting on carbohydrates and derivatives inhibitor of racemases acting on carbohydrates and derivatives (EC 5.1.3.*) inhibitors of racemases acting on carbohydrates and derivatives inhibitors of racemases acting on carbohydrates and derivatives (EC 5.1.3.*) EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor EC 5.1.99.* (racemases acting on other compounds) inhibitor EC 5.1.99.* (racemases acting on other compounds) inhibitors EC 5.1.99.* inhibitor EC 5.1.99.* inhibitors inhibitor of racemases acting on other compounds (EC 5.1.99.*) inhibitors of racemases acting on other compounds (EC 5.1.99.*) EC 5.1.99.* (racemases acting on other compounds) inhibitor EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor 4-epimerase inhibitor 4-epimerase inhibitors EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitors EC 5.1.3.2 inhibitor EC 5.1.3.2 inhibitors UDP-D-galactose 4-epimerase inhibitor UDP-D-galactose 4-epimerase inhibitors UDP-alpha-D-glucose 4-epimerase inhibitor UDP-alpha-D-glucose 4-epimerase inhibitors UDP-galactose 4-epimerase inhibitor UDP-galactose 4-epimerase inhibitors UDP-glucose 4-epimerase (EC 5.1.3.2) inhibitor UDP-glucose 4-epimerase (EC 5.1.3.2) inhibitors UDP-glucose 4-epimerase inhibitor UDP-glucose 4-epimerase inhibitors UDP-glucose epimerase inhibitor UDP-glucose epimerase inhibitors UDPG-4-epimerase inhibitor UDPG-4-epimerase inhibitors UDPgalactose 4-epimerase inhibitor UDPgalactose 4-epimerase inhibitors UDPglucose 4-epimerase inhibitor UDPglucose 4-epimerase inhibitors galactowaldenase inhibitor galactowaldenase inhibitors uridine diphosphate galactose 4-epimerase inhibitor uridine diphosphate galactose 4-epimerase inhibitors uridine diphosphate glucose 4-epimerase inhibitor uridine diphosphate glucose 4-epimerase inhibitors uridine diphospho-galactose-4-epimerase inhibitor uridine diphospho-galactose-4-epimerase inhibitors uridine diphosphoglucose 4-epimerase inhibitor uridine diphosphoglucose 4-epimerase inhibitors uridine diphosphoglucose epimerase inhibitor uridine diphosphoglucose epimerase inhibitors EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor refrigerant refrigerants refrigerant EC 3.1.1.1 (carboxylesterase) inhibitor Alpha-carboxylesterase inhibitor Alpha-carboxylesterase inhibitors Beta-esterase inhibitor Beta-esterase inhibitors EC 3.1.1.1 (carboxylesterase) inhibitors ali-esterase inhibitor ali-esterase inhibitors butyrate esterase inhibitor butyrate esterase inhibitors butyryl esterase inhibitor butyryl esterase inhibitors carboxyl ester hydrolase inhibitor carboxyl ester hydrolase inhibitors carboxylate esterase inhibitor carboxylate esterase inhibitors carboxylesterase inhibitor carboxylesterase inhibitors carboxylic acid esterase inhibitor carboxylic acid esterase inhibitors carboxylic esterase inhibitor carboxylic esterase inhibitors carboxylic-ester hydrolase inhibitor carboxylic-ester hydrolase inhibitors cocaine esterase inhibitor cocaine esterase inhibitors esterase A inhibitor esterase A inhibitors esterase B inhibitor esterase B inhibitors esterase D inhibitor esterase D inhibitors methylbutyrase inhibitor methylbutyrase inhibitors methylbutyrate esterase inhibitor methylbutyrate esterase inhibitors monobutyrase inhibitor monobutyrase inhibitors nonspecific carboxylesterase inhibitor nonspecific carboxylesterase inhibitors procaine esterase inhibitor procaine esterase inhibitors propionyl esterase inhibitor propionyl esterase inhibitors serine esterase inhibitor serine esterase inhibitors triacetin esterase inhibitor triacetin esterase inhibitors vitamin A esterase inhibitor vitamin A esterase inhibitors EC 3.1.1.1 (carboxylesterase) inhibitor venom venoms venom protein kinase A agonist protein kinase A agonists protein kinase A agonist adenylate cyclase agonist adenylate cyclase agonists adenylyl cyclase agonist adenylyl cyclase agonists adenylate cyclase agonist vesicant blister agent blister agents vesicants vesicant Hsp70 inducer Hsp70 activator Hsp70 activators Hsp70 inducers heat shock protein 70 activator heat shock protein 70 activators heat shock protein 70 inducer heat shock protein 70 inducers Hsp70 inducer EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase inhibitor 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase inhibitors 3-hydroxy-3-methylglutaryl-CoA reductase kinase inhibitor 3-hydroxy-3-methylglutaryl-CoA reductase kinase inhibitors AMP-activated protein kinase inhibitor AMP-activated protein kinase inhibitors AMPK inhibitor AMPK inhibitors ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase inhibitor ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase inhibitors EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) inhibitor EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) inhibitors EC 2.7.11.31 inhibitor EC 2.7.11.31 inhibitors EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitors HMG-CoA reductase kinase inhibitor HMG-CoA reductase kinase inhibitors STK29 inhibitor STK29 inhibitors [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase inhibitor [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase inhibitors [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase inhibitor [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase inhibitors beta-hydroxy-beta-methylglutaryl-CoA reductase kinase inhibitor beta-hydroxy-beta-methylglutaryl-CoA reductase kinase inhibitors hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) inhibitor hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) inhibitors hydroxymethylglutaryl coenzyme A reductase kinase inhibitor hydroxymethylglutaryl coenzyme A reductase kinase inhibitors hydroxymethylglutaryl-CoA reductase kinase inhibitor hydroxymethylglutaryl-CoA reductase kinase inhibitors reductase kinase inhibitor reductase kinase inhibitors EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor bone morphogenetic protein receptor antagonist BMP antagonist BMP antagonists BMP receptor inhibitor BMP receptor inhibitors bone morphogenetic protein antagonists bone morphogenetic protein inhibitor bone morphogenetic protein receptor inhibitors bone morphogenetic protein receptor antagonist fundamental metabolite essential metabolite essential metabolites fundamental metabolites fundamental metabolite EC 4.6.1.2 (guanylate cyclase) inhibitor EC 4.6.1.2 (guanylate cyclase) inhibitors EC 4.6.1.2 inhibitor EC 4.6.1.2 inhibitors GTP diphosphate-lyase (cyclizing) inhibitor GTP diphosphate-lyase (cyclizing) inhibitors GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitor GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitors guanyl cyclase inhibitor guanyl cyclase inhibitors guanylyl cyclase inhibitor guanylyl cyclase inhibitors EC 4.6.1.2 (guanylate cyclase) inhibitor tropomyosin-related kinase B receptor antagonist TrkB receptor antagonist TrkB receptor antagonists tropomyosin-related kinase B receptor antagonists tropomyosin-related kinase B receptor antagonist EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitor EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitors myristoyl-CoA-protein N-myristoyltransferase inhibitor myristoyl-CoA-protein N-myristoyltransferase inhibitors myristoyl-coenzyme A:protein N-myristoyl transferase inhibitor myristoyl-coenzyme A:protein N-myristoyl transferase inhibitors peptide N-myristoyltransferase inhibitor peptide N-myristoyltransferase inhibitors protein N-myristoyltransferase inhibitor protein N-myristoyltransferase inhibitors tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase inhibitor tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase inhibitors EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitor EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor Delta(24)-sterol reductase (EC 1.3.1.72) inhibitor Delta(24)-sterol reductase (EC 1.3.1.72) inhibitors Delta(24)-sterol reductase inhibitor Delta(24)-sterol reductase inhibitors EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitors EC 1.3.1.72 inhibitor EC 1.3.1.72 inhibitors lanosterol Delta (24)-reductase sterol:NADP(+) Delta(24)-oxidoreductase EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor EC 2.5.1.6 (methionine adenosyltransferase) inhibitor ATP-methionine adenosyltransferase inhibitor ATP-methionine adenosyltransferase inhibitors ATP:L-methionine S-adenosyltransferase inhibitor ATP:L-methionine S-adenosyltransferase inhibitors AdoMet synthetase inhibitor AdoMet synthetase inhibitors EC 2.5.1.6 (methionine adenosyltransferase) inhibitors EC 2.5.1.6 inhibitor EC 2.5.1.6 inhibitors S-adenosyl-L-methionine synthetase inhibitor S-adenosyl-L-methionine synthetase inhibitors S-adenosylmethionine synthase inhibitor S-adenosylmethionine synthase inhibitors S-adenosylmethionine synthetase inhibitor S-adenosylmethionine synthetase inhibitors adenosylmethionine synthetase inhibitor adenosylmethionine synthetase inhibitors methionine S-adenosyltransferase inhibitor methionine S-adenosyltransferase inhibitors methionine-activating enzyme inhibitor methionine-activating enzyme inhibitors EC 2.5.1.6 (methionine adenosyltransferase) inhibitor EC 2.7.1.91 (sphingosine kinase) inhibitor ATP:sphinganine 1-phosphotransferase inhibitor ATP:sphinganine 1-phosphotransferase inhibitors EC 2.7.1.91 (sphinganine kinase) inhibitor EC 2.7.1.91 (sphinganine kinase) inhibitors EC 2.7.1.91 (sphingosine kinase) inhibitors EC 2.7.1.91 inhibitor EC 2.7.1.91 inhibitors SGK inhibitor SGK inhibitors SK inhibitor SK inhibitors dihydrosphingosine kinase (phosphorylating) inhibitor dihydrosphingosine kinase (phosphorylating) inhibitors dihydrosphingosine kinase inhibitor dihydrosphingosine kinase inhibitors sphinganine kinase inhibitor sphinganine kinase inhibitors sphingoid base kinase inhibitor sphingoid base kinase inhibitors sphingosine kinase (phosphorylating) inhibitor sphingosine kinase (phosphorylating) inhibitors EC 2.7.1.91 (sphingosine kinase) inhibitor EC 2.7.11.18 (myosin-light-chain kinase) inhibitor ATP:[myosin-light-chain] O-phosphotransferase inhibitor ATP:[myosin-light-chain] O-phosphotransferase inhibitors ATP:myosin-light-chain O-phosphotransferase inhibitor ATP:myosin-light-chain O-phosphotransferase inhibitors EC 2.7.11.18 (myosin-light-chain kinase) inhibitors EC 2.7.11.18 inhibitor EC 2.7.11.18 inhibitors MLCK inhibitor MLCK inhibitors MLCkase inhibitor MLCkase inhibitors [myosin-light-chain] kinase inhibitor [myosin-light-chain] kinase inhibitors calcium/calmodulin-dependent myosin light chain kinase inhibitor calcium/calmodulin-dependent myosin light chain kinase inhibitors myosin kinase inhibitor myosin kinase inhibitors myosin light chain kinase inhibitor myosin light chain kinase inhibitors myosin light chain protein kinase inhibitor myosin light chain protein kinase inhibitors myosin light-chain kinase (phosphorylating) inhibitor myosin light-chain kinase (phosphorylating) inhibitors myosin light-chain kinase inhibitor myosin light-chain kinase inhibitors myosin-light-chain kinase (EC 2.7.11.18) inhibitor myosin-light-chain kinase (EC 2.7.11.18) inhibitors myosin-light-chain kinase inhibitor myosin-light-chain kinase inhibitors smooth-muscle-myosin-light-chain kinase inhibitor smooth-muscle-myosin-light-chain kinase inhibitors EC 2.7.11.18 (myosin-light-chain kinase) inhibitor nematode metabolite nematode metabolites nematode metabolite Caenorhabditis elegans metabolite C. elegans metabolite C. elegans metabolites Caenorhabditis elegans metabolites Caenorhabditis elegans metabolite survivin dimerisation modulator survivin dimerisation modulators survivin modulator survivin modulators survivin dimerisation modulator EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitor EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitors EC 3.6.1.* (hydrolases acting on acid anhydrides in phosphorus-containing anhydrides) inhibitor EC 3.6.1.* (hydrolases acting on acid anhydrides in phosphorus-containing anhydrides) inhibitors EC 3.6.1.* inhibitor EC 3.6.1.* inhibitors hydrolases acting on acid anhydrides in P-containing anhydrides (EC 3.6.1.*) inhibitor hydrolases acting on acid anhydrides in P-containing anhydrides (EC 3.6.1.*) inhibitors hydrolases acting on acid anhydrides in phosphorus-containing anhydrides (EC 3.6.1.*) inhibitor hydrolases acting on acid anhydrides in phosphorus-containing anhydrides (EC 3.6.1.*) inhibitors EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitor EC 3.6.1.3 (adenosinetriphosphatase) inhibitor (Ca(2+) + Mg(2+))-ATPase inhibitor (Ca(2+) + Mg(2+))-ATPase inhibitors ATP hydrolase inhibitor ATP hydrolase inhibitors ATP monophosphatase inhibitor ATP monophosphatase inhibitors ATP phosphohydrolase inhibitor ATP phosphohydrolase inhibitors ATPase inhibitor ATPase inhibitors EC 3.6.1.3 (adenosinetriphosphatase) inhibitors EC 3.6.1.3 inhibitor EC 3.6.1.3 inhibitors HCO3(-)-ATPase inhibitor HCO3(-)-ATPase inhibitors SV40 T-antigen inhibitor SV40 T-antigen inhibitors adenosine 5'-triphosphatase inhibitor adenosine 5'-triphosphatase inhibitors adenosine triphosphatase inhibitor adenosine triphosphatase inhibitors adenosinetriphosphatase (EC 3.6.1.3) inhibitor adenosinetriphosphatase (EC 3.6.1.3) inhibitors adenosinetriphosphatase inhibitor adenosinetriphosphatase inhibitors adenylpyrophosphatase inhibitor adenylpyrophosphatase inhibitors complex V (mitochondrial electron transport) inhibitor complex V (mitochondrial electron transport) inhibitors triphosphatase inhibitor triphosphatase inhibitors EC 3.6.1.3 (adenosinetriphosphatase) inhibitor archaeal metabolite archaeal metabolites archaeal metabolite melatonin receptor agonist melatonin receptor agonists melatonin receptor agonist EC 3.4.22.52 (calpain-1) inhibitor EC 3.4.22.52 (calpain-1) inhibitors EC 3.4.22.52 inhibitor EC 3.4.22.52 inhibitors calcium-activated neutral protease I inhibitor calcium-activated neutral protease I inhibitors calpain-1 (EC 3.4.22.52) inhibitor calpain-1 (EC 3.4.22.52) inhibitors calpain-1 inhibitor calpain-1 inhibitors mu-calpain inhibitor mu-calpain inhibitors EC 3.4.22.52 (calpain-1) inhibitor plasticiser plasticisers plasticizer plasticizers plasticiser potassium channel opener potassium channel activator potassium channel activators potassium channel agonist potassium channel agonists potassium channel openers potassium channel opener EC 3.4.24.35 (gelatinase B) inhibitor 92-kDa gelatinase inhibitor 92-kDa gelatinase inhibitors 92-kDa type IV collagenase inhibitor 92-kDa type IV collagenase inhibitors 95 kDa type IV collagenase/gelatinase inhibitor 95 kDa type IV collagenase/gelatinase inhibitors EC 3.4.24.35 (gelatinase B) inhibitors EC 3.4.24.35 inhibitor EC 3.4.24.35 inhibitors MMP 9 inhibitor MMP 9 inhibitors collagenase IV inhibitor collagenase IV inhibitors collagenase type IV inhibitor collagenase type IV inhibitors gelatinase B (EC 3.4.24.35) inhibitor gelatinase B (EC 3.4.24.35) inhibitors gelatinase B inhibitor gelatinase B inhibitors gelatinase MMP 9 inhibitor gelatinase MMP 9 inhibitors macrophage gelatinase inhibitor macrophage gelatinase inhibitors matrix metalloproteinase 9 inhibitor matrix metalloproteinase 9 inhibitors type IV collagen metalloproteinase inhibitor type IV collagen metalloproteinase inhibitors type V collagenase inhibitor type V collagenase inhibitors EC 3.4.24.35 (gelatinase B) inhibitor EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor ATP:protein phosphotransferase (MAPKK-activated) inhibitor ATP:protein phosphotransferase (MAPKK-activated) inhibitors Dp38 inhibitor Dp38 inhibitors EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors EC 2.7.11.24 inhibitor EC 2.7.11.24 inhibitors ERK inhibitor ERK inhibitors ERK1 inhibitor ERK1 inhibitors ERK2 inhibitor ERK2 inhibitors JNK inhibitor JNK inhibitors JNK3alpha1 inhibitor JNK3alpha1 inhibitors LeMPK3 inhibitor LeMPK3 inhibitors MAP kinase inhibitor MAP kinase inhibitors MAP-2 kinase inhibitor MAP-2 kinase inhibitors MAPK inhibitor MAPK inhibitors MBP kinase I inhibitor MBP kinase I inhibitors MBP kinase II inhibitor MBP kinase II inhibitors MEK inhibitor MEK inhibitors PMK-1 inhibitor PMK-1 inhibitors PMK-2 inhibitor PMK-2 inhibitors PMK-3 inhibitor PMK-3 inhibitors SAPK inhibitor SAPK inhibitors STK26 inhibitor STK26 inhibitors c-Jun N-terminal kinase inhibitor c-Jun N-terminal kinase inhibitors extracellular signal-regulated kinase inhibitor extracellular signal-regulated kinase inhibitors microtubule-associated protein 2 kinase inhibitor microtubule-associated protein 2 kinase inhibitors microtubule-associated protein kinase inhibitor microtubule-associated protein kinase inhibitors mitogen-activated protein kinase (EC 2.7.11.24) inhibitor mitogen-activated protein kinase (EC 2.7.11.24) inhibitors mitogen-activated protein kinase inhibitor mitogen-activated protein kinase inhibitors myelin basic protein kinase inhibitor myelin basic protein kinase inhibitors p38-2 inhibitor p38-2 inhibitors p38delta inhibitor p38delta inhibitors p42 mitogen-activated protein kinase inhibitor p42 mitogen-activated protein kinase inhibitors p42(mapk) inhibitor p42(mapk) inhibitors p44mpk inhibitor p44mpk inhibitors pp42 inhibitor pp42 inhibitors pp44(mapk) inhibitor pp44(mapk) inhibitors stress-activated protein kinase inhibitor stress-activated protein kinase inhibitors EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitors EC 1.11.2.* inhibitor EC 1.11.2.* inhibitors EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor EC 1.11.2.2 (myeloperoxidase) inhibitor EC 1.11.2.2 (myeloperoxidase) inhibitors EC 1.11.2.2 inhibitor EC 1.11.2.2 inhibitors MPO inhibitor MPO inhibitors chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitor chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitors myeloperoxidase (EC 1.11.2.2) inhibitor myeloperoxidase (EC 1.11.2.2) inhibitors myeloperoxidase inhibitor myeloperoxidase inhibitors verdoperoxidase inhibitor verdoperoxidase inhibitors EC 1.11.2.2 (myeloperoxidase) inhibitor flame retardant flame retardants flame retardant paroxetine (-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine Paroxetine paroxetina paroxetinum paroxetine glycerophosphoinositol synthesis inhibitor GPI synthesis inhibitor GPI synthesis inhibitors glycerophosphoinositol synthesis inhibitors glycerophosphoinositol synthesis inhibitor EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitor EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitors EC 6.1.1.2 inhibitor EC 6.1.1.2 inhibitors L-tryptophan-tRNA(Trp) ligase (AMP-forming) inhibitor L-tryptophan-tRNA(Trp) ligase (AMP-forming) inhibitors L-tryptophan:tRNA(Trp) ligase (AMP-forming) inhibitor L-tryptophan:tRNA(Trp) ligase (AMP-forming) inhibitors TrpRS inhibitor TrpRS inhibitors tryptophan translase inhibitor tryptophan translase inhibitors tryptophan--tRNA ligase (EC 6.1.1.2) inhibitor tryptophan--tRNA ligase (EC 6.1.1.2) inhibitors tryptophanyl ribonucleic synthetase inhibitor tryptophanyl ribonucleic synthetase inhibitors tryptophanyl-tRNA synthase inhibitor tryptophanyl-tRNA synthase inhibitors tryptophanyl-tRNA synthetase inhibitor tryptophanyl-tRNA synthetase inhibitors tryptophanyl-transfer RNA synthetase inhibitor tryptophanyl-transfer RNA synthetase inhibitors tryptophanyl-transfer ribonucleate synthetase inhibitor tryptophanyl-transfer ribonucleate synthetase inhibitors tryptophanyl-transfer ribonucleic acid synthetase inhibitor tryptophanyl-transfer ribonucleic acid synthetase inhibitors tryptophanyl-transfer ribonucleic synthetase inhibitor tryptophanyl-transfer ribonucleic synthetase inhibitors EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitor phenacetin 1-Acetamido-4-ethoxybenzene 4-Ethoxyacetanilide Acetophenetidin Acetophenetidine Acetophenetin Acetphenetidin Achrocidin Codempiral Commotional Contradol Contradouleur Fenacetina N-(4-ethoxyphenyl)acetamide Phenacetin Phenacetine Phenacetinum phenacetin phenacetin phytochrome chromophore phytochrome chromophores phytochrome chromophore animal growth promotant animal growth promotants animal growth promoter animal growth promoters animal growth promotant EC 2.7.11.22 (cyclin-dependent kinase) inhibitor ATP:cyclin phosphotransferase inhibitor ATP:cyclin phosphotransferase inhibitors Bur1 Cdk inhibitor Bur1 Cdk inhibitors Bur1 inhibitor Bur1 inhibitors CDK inhibitor CDK inhibitors Cak1 inhibitor Cak1 inhibitors Cak1p inhibitor Cak1p inhibitors Cdc28p inhibitor Cdc28p inhibitors Cdk-activating protein kinase inhibitors Cdk1 inhibitor Cdk1 inhibitors Cdk19 inhibitor Cdk19 inhibitors Cdk2 inhibitor Cdk2 inhibitors Cdk3 inhibitor Cdk3 inhibitors Cdk4 inhibitor Cdk4 inhibitors Cdk5 inhibitor Cdk5 inhibitors Cdk6 inhibitor Cdk6 inhibitors Cdk7 inhibitor Cdk7 inhibitors Cdk8 inhibitor Cdk8 inhibitors Cdk9 inhibitor Cdk9 inhibitors D-type cyclin kinase inhibitor D-type cyclin kinase inhibitors EC 2.7.11.22 (cyclin-dependent kinase) inhibitors EC 2.7.11.22 inhibitor EC 2.7.11.22 inhibitors PCTAIRE-1 inhibitor PCTAIRE-1 inhibitors STK25 inhibitor STK25 inhibitors cdc2 inhibitor cdc2 inhibitors cdc2 kinase inhibitor cdc2 kinase inhibitors cdk-activating kinase inhibitor cdk-activating kinase inhibitors cyclin A-activated cdc2 inhibitor cyclin A-activated cdc2 inhibitors cyclin A-activated cdk2 inhibitor cyclin A-activated cdk2 inhibitors cyclin D-cdk6 kinase inhibitor cyclin D-cdk6 kinase inhibitors cyclin D-dependent kinase inhibitor cyclin D-dependent kinase inhibitors cyclin E kinase inhibitor cyclin E kinase inhibitors cyclin-A associated kinase inhibitor cyclin-A associated kinase inhibitors cyclin-dependent kinase 6 inhibitor cyclin-dependent kinase 6 inhibitors cyclin-dependent kinase inhibitor cyclin-dependent kinase inhibitors cyclin-dependent kinase-2 inhibitor cyclin-dependent kinase-2 inhibitors cyclin-dependent kinase-4 inhibitor cyclin-dependent kinase-4 inhibitors cyclin-dependent protein kinase activating kinase inhibitor cyclin-dependent protein kinase activating kinase inhibitors cyk inhibitor cyk inhibitors ndk inhibitor ndk inhibitors neuronal cdc2-like kinase inhibitor neuronal cdc2-like kinase inhibitors EC 2.7.11.22 (cyclin-dependent kinase) inhibitor EC 6.1.1.12 (aspartate--tRNA ligase) inhibitor EC 6.1.1.12 (aspartate--tRNA ligase) inhibitors EC 6.1.1.12 inhibitor EC 6.1.1.12 inhibitors L-aspartate:tRNA(Asp) ligase (AMP-forming) inhibitor L-aspartate:tRNA(Asp) ligase (AMP-forming) inhibitors aspartic acid translase inhibitor aspartic acid translase inhibitors aspartyl ribonucleate synthetase inhibitor aspartyl ribonucleate synthetase inhibitors aspartyl ribonucleic synthetase inhibitor aspartyl ribonucleic synthetase inhibitors aspartyl-tRNA synthetase inhibitors aspartyl-transfer RNA synthetase inhibitor aspartyl-transfer RNA synthetase inhibitors aspartyl-transfer ribonucleic acid synthetase inhibitor aspartyl-transfer ribonucleic acid synthetase inhibitors EC 6.1.1.12 (aspartate--tRNA ligase) inhibitor EC 3.4.22.53 (calpain-2) inhibitor EC 3.4.22.53 (calpain-2) inhibitors EC 3.4.22.53 inhibitor EC 3.4.22.53 inhibitors calcium-activated neutral protease II inhibitor calcium-activated neutral protease II inhibitors calpain-2 (EC 3.4.22.53) inhibitor calpain-2 (EC 3.4.22.53) inhibitors m-calpain inhibitor m-calpain inhibitors milli-calpain inhibitor milli-calpain inhibitors EC 3.4.22.53 (calpain-2) inhibitor EC 3.4.22.54 (calpain-3) inhibitor CANP 3 inhibitor CANP 3 inhibitors CAPN3 inhibitor CAPN3 inhibitors EC 3.4.22.54 (calpain-3) inhibitors EC 3.4.22.54 inhibitor EC 3.4.22.54 inhibitors calcium-activated neutral proteinase 3 inhibitor calcium-activated neutral proteinase 3 inhibitors calpain 3 inhibitor calpain 3 inhibitors calpain L3 inhibitor calpain L3 inhibitors calpain p94 inhibitor calpain p94 inhibitors calpain-3 (EC 3.4.22.54) inhibitor calpain-3 (EC 3.4.22.54) inhibitors muscle calpain inhibitor muscle calpain inhibitors muscle-specific calcium-activated neutral protease 3 inhibitor muscle-specific calcium-activated neutral protease 3 inhibitors p94 inhibitor p94 inhibitors EC 3.4.22.54 (calpain-3) inhibitor calpain inhibitor calpain inhibitors calpain inhibitor glucocorticoid receptor antagonist glucocorticoid receptor antagonists glucocorticoid receptor antagonist gut flora metabolite gut flora metabolites gut flora metabolite EC 3.4.24.11 (neprilysin) inhibitor CALLA (common acute lymphoblastic leukemia-associated) antigens inhibitor CALLA (common acute lymphoblastic leukemia-associated) antigens inhibitors CALLA antigen inhibitor CALLA antigen inhibitors CALLA glycoprotein inhibitor CALLA glycoprotein inhibitors CALLA glycoproteins inhibitor CALLA glycoproteins inhibitors CALLA inhibitor CALLA inhibitors CD10 inhibitor CD10 inhibitors EC 3.4.24.11 (neprilysin) inhibitors EC 3.4.24.11 inhibitor EC 3.4.24.11 inhibitors NEP inhibitor NEP inhibitors acute lymphoblastic leukemia antigen inhibitor acute lymphoblastic leukemia antigen inhibitors common acute lymphoblastic leukemia antigen inhibitor common acute lymphoblastic leukemia antigen inhibitors common acute lymphoblastic leukemia-associated antigens inhibitor common acute lymphoblastic leukemia-associated antigens inhibitors endopeptidase 24.11 inhibitor endopeptidase 24.11 inhibitors endopeptidase inhibitor endopeptidase inhibitors endopeptidase-2 inhibitor endopeptidase-2 inhibitors enkephalinase inhibitor enkephalinase inhibitors kidney-brush-border neutral endopeptidase inhibitor kidney-brush-border neutral endopeptidase inhibitors kidney-brush-border neutral peptidase inhibitor kidney-brush-border neutral peptidase inhibitors kidney-brush-border neutral proteinase inhibitor kidney-brush-border neutral proteinase inhibitors membrane metalloendopeptidase inhibitor membrane metalloendopeptidase inhibitors neprilysin (EC 3.4.24.11) inhibitor neprilysin (EC 3.4.24.11) inhibitors neprilysin inhibitor neprilysin inhibitors neutral endopeptidase 24.11 inhibitor neutral endopeptidase 24.11 inhibitors neutral endopeptidase inhibitor neutral endopeptidase inhibitors neutral metallendopeptidase inhibitor neutral metallendopeptidase inhibitors EC 3.4.24.11 (neprilysin) inhibitor EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitors EC 3.4.24.71 inhibitor EC 3.4.24.71 inhibitors ECE-1 inhibitor ECE-1 inhibitors endothelin-converting enzyme 1 (EC 3.4.24.71) inhibitor endothelin-converting enzyme 1 (EC 3.4.24.71) inhibitors endothelin-converting enzyme 1 inhibitor endothelin-converting enzyme 1 inhibitors endothelin-converting enzyme inhibitor endothelin-converting enzyme inhibitors EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor EC 4.1.2.27 (sphinganine-1-phosphate aldolase) inhibitor EC 4.1.2.27 (sphinganine-1-phosphate aldolase) inhibitors EC 4.1.2.27 inhibitor EC 4.1.2.27 inhibitors S1P lyase inhibitor S1P lyase inhibitors dihydrosphingosine 1-phosphate aldolase inhibitor dihydrosphingosine 1-phosphate aldolase inhibitors sphinganine-1-phosphate alkanal-lyase inhibitor sphinganine-1-phosphate alkanal-lyase inhibitors sphinganine-1-phosphate lyase inhibitor sphinganine-1-phosphate lyase inhibitors sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming) inhibitor sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming) inhibitors sphinganine-1-phosphate palmitaldehyde-lyase inhibitor sphinganine-1-phosphate palmitaldehyde-lyase inhibitors sphingosine-1-phosphate aldolase inhibitor sphingosine-1-phosphate aldolase inhibitors sphingosine-1-phosphate lyase inhibitor sphingosine-1-phosphate lyase inhibitors EC 4.1.2.27 (sphinganine-1-phosphate aldolase) inhibitor EC 4.1.2.* (aldehyde-lyase) inhibitor EC 4.1.2.* (aldehyde-lyase) inhibitors EC 4.1.2.* (aldehyde-lyases) inhibitor EC 4.1.2.* (aldehyde-lyases) inhibitors EC 4.1.2.* inhibitor EC 4.1.2.* inhibitors EC 4.1.2.* (aldehyde-lyase) inhibitor Daphnia galeata metabolite Daphnia galeata metabolites Daphnia galeata metabolite crustacean metabolite crustacean metabolites crustacean metabolite Daphnia magna metabolite Daphnia magna metabolites Daphnia magna metabolite Daphnia metabolite Daphnia metabolites Daphnia metabolite EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitors EC 1.3.5.1 inhibitor EC 1.3.5.1 inhibitors SDH inhibitor SDH inhibitors complex II inhibitor complex II inhibitors succinate dehydrogenase (ubiquinone) inhibitor succinate dehydrogenase (ubiquinone) inhibitors succinate dehydrogenase complex inhibitor succinate dehydrogenase complex inhibitors succinate dehydrogenase inhibitor succinate dehydrogenase inhibitors succinate:quinone oxidoreductase inhibitor succinate:quinone oxidoreductase inhibitors succinate:ubiquinone oxidoreductase inhibitor succinate:ubiquinone oxidoreductase inhibitors succinic dehydrogenase inhibitor succinic dehydrogenase inhibitors EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor kairomone kairomones kairomone Daphnia pulex metabolite Daphnia pulex metabolites Daphnia pulex metabolite Daphnia tenebrosa metabolite Daphnia tenebrosa metabolites Daphnia tenebrosa metabolite EC 6.2.1.* (acid-thiol ligase) inhibitor EC 6.2.1.* (acid-thiol ligase) inhibitors EC 6.2.1.* (acid-thiol ligases) inhibitor EC 6.2.1.* (acid-thiol ligases) inhibitors EC 6.2.1.* inhibitor EC 6.2.1.* inhibitors EC 6.2.1.* (acid-thiol ligase) inhibitor EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor ACS3 inhibitor ACS3 inhibitors EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitors EC 6.2.1.3 inhibitor EC 6.2.1.3 inhibitors FAA1 inhibitor FAA1 inhibitors LCFA synthetase inhibitor LCFA synthetase inhibitors acyl coenzyme A synthetase inhibitor acyl coenzyme A synthetase inhibitors acyl-CoA ligase inhibitor acyl-CoA ligase inhibitors acyl-CoA synthetase inhibitor acyl-CoA synthetase inhibitors acyl-activating enzyme inhibitor acyl-activating enzyme inhibitors acyl-coenzyme A ligase inhibitor acyl-coenzyme A ligase inhibitors arachidonyl-CoA synthetase inhibitor arachidonyl-CoA synthetase inhibitors fatty acid CoA ligase inhibitor fatty acid CoA ligase inhibitors fatty acid elongase inhibitor fatty acid elongase inhibitors fatty acid thiokinase (long chain) inhibitor fatty acid thiokinase (long chain) inhibitors fatty acyl-coenzyme A synthetase inhibitor fatty acyl-coenzyme A synthetase inhibitors lignoceroyl-CoA synthase inhibitor lignoceroyl-CoA synthase inhibitors long chain fatty acyl-CoA synthetase inhibitor long chain fatty acyl-CoA synthetase inhibitors long-chain acyl CoA synthetase inhibitor long-chain acyl CoA synthetase inhibitors long-chain acyl-CoA synthetase I inhibitor long-chain acyl-CoA synthetase I inhibitors long-chain acyl-CoA synthetase II inhibitor long-chain acyl-CoA synthetase II inhibitors long-chain acyl-coenzyme A synthetase inhibitor long-chain acyl-coenzyme A synthetase inhibitors long-chain fatty acid:CoA ligase (AMP-forming) inhibitor long-chain fatty acid:CoA ligase (AMP-forming) inhibitors long-chain fatty acyl coenzyme A synthetase inhibitor long-chain fatty acyl coenzyme A synthetase inhibitors oleoyl-CoA synthetase inhibitor oleoyl-CoA synthetase inhibitors palmitoyl coenzyme A synthetase inhibitor palmitoyl coenzyme A synthetase inhibitors palmitoyl-CoA ligase inhibitor palmitoyl-CoA ligase inhibitors palmitoyl-CoA synthase inhibitor palmitoyl-CoA synthase inhibitors pristanoyl-CoA synthetase inhibitor pristanoyl-CoA synthetase inhibitors stearoyl-CoA synthetase inhibitor stearoyl-CoA synthetase inhibitors thiokinase inhibitor thiokinase inhibitors EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor orexin receptor antagonist orexin receptor antagonists orexin receptor antagonist protease-activated receptor-1 antagonist PAR-1 antagonist PAR-1 antagonists PAR-1 receptor antagonist PAR-1 receptor antagonists PAR1 antagonist PAR1 antagonists coagulation factor II (thrombin) receptor antagonist coagulation factor II (thrombin) receptor antagonists coagulation factor II receptor antagonist coagulation factor II receptor antagonists coagulation factor II thrombin receptor antagonist coagulation factor II thrombin receptor antagonists protease activated receptor 1 antagonist protease activated receptor 1 antagonists protease-activated receptor 1 antagonist protease-activated receptor 1 antagonists protease-activated receptor-1 antagonists proteinase-activated receptor 1 antagonist proteinase-activated receptor 1 antagonists protease-activated receptor-1 antagonist EC 1.14.13.72 (methylsterol monooxygenase) inhibitor 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitor 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitors 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitor 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitors 4-methylsterol oxidase inhibitor 4-methylsterol oxidase inhibitors EC 1.14.13.72 (ethylsterol monooxygenase) inhibitors EC 1.14.13.72 inhibitor EC 1.14.13.72 inhibitors methylsterol hydroxylase inhibitor methylsterol hydroxylase inhibitors methylsterol monooxygenase (EC 1.14.13.72) inhibitor methylsterol monooxygenase (EC 1.14.13.72) inhibitors methylsterol monooxygenase inhibitor methylsterol monooxygenase inhibitors EC 1.14.13.72 (methylsterol monooxygenase) inhibitor sterol biosynthesis inhibitor sterol biosynthesis inhibitors sterol biosynthesis inhibitor EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitor 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitors C-14 sterol reductase inhibitor C-14 sterol reductase inhibitors Delta(14)-sterol reductase (EC 1.3.1.70) inhibitor Delta(14)-sterol reductase (EC 1.3.1.70) inhibitors Delta(14)-sterol reductase inhibitor Delta(14)-sterol reductase inhibitors EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitors EC 1.3.1.70 inhibitor EC 1.3.1.70 inhibitors sterol C14-reductase inhibitor sterol C14-reductase inhibitors EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor marine xenobiotic metabolite marine xenobiotic metabolites marine xenobiotic metabolite steatosis inducing agent steatosis inducing agents steatosis inducing drug steatosis inducing drugs steatosis inducing agent hepatic steatosis inducing agent hepatic steatosis inducing agents hepatic steatosis inducing drug hepatic steatosis inducing drugs hepatic steatosis inducing agent sterol demethylation inhibitor sterol demethylation inhibitors sterol demethylation inhibitor phospholipid biosynthesis inhibitor phospholipid biosynthesis inhibitors phospholipid biosynthesis inhibitor EC 2.4.1.231 [alpha,alpha-trehalose phosphorylase (configuration-retaining)] inhibitor EC 2.4.1.231 [alpha,alpha-trehalose phosphorylase (configuration-retaining)] inhibitors EC 2.4.1.231 inhibitor EC 2.4.1.231 inhibitors alpha,alpha-trehalose phosphorylase (configuration-retaining) (EC 2.4.1.231) inhibitor alpha,alpha-trehalose phosphorylase (configuration-retaining) (EC 2.4.1.231) inhibitors alpha,alpha-trehalose phosphorylase (configuration-retaining) inhibitor alpha,alpha-trehalose phosphorylase (configuration-retaining) inhibitors alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase inhibitor alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase inhibitors trehalose phosphorylase inhibitor trehalose phosphorylase inhibitors EC 2.4.1.231 [alpha,alpha-trehalose phosphorylase (configuration-retaining)] inhibitor EC 2.4.1.64 (alpha,alpha-trehalose phosphorylase) inhibitor EC 2.4.1.64 (alpha,alpha-trehalose phosphorylase) inhibitors EC 2.4.1.64 inhibitor EC 2.4.1.64 inhibitors alpha,alpha-trehalose phosphorylase (EC 2.4.1.64) inhibitor alpha,alpha-trehalose phosphorylase (EC 2.4.1.64) inhibitors alpha,alpha-trehalose phosphorylase inhibitor alpha,alpha-trehalose phosphorylase inhibitors alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase inhibitor alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase inhibitors trehalose phosphorylase inhibitor trehalose phosphorylase inhibitors EC 2.4.1.64 (alpha,alpha-trehalose phosphorylase) inhibitor EC 3.2.1.28 (alpha,alpha-trehalase) inhibitor EC 3.2.1.28 (alpha,alpha-trehalase) inhibitors EC 3.2.1.28 inhibitor EC 3.2.1.28 inhibitors alpha,alpha-trehalase (EC 3.2.1.28) inhibitor alpha,alpha-trehalase (EC 3.2.1.28) inhibitors alpha,alpha-trehalase inhibitor alpha,alpha-trehalase inhibitors EC 3.2.1.28 (alpha,alpha-trehalase) inhibitor nonstructural protein 5A inhibitor HCV non-structural protein 5A inhibitor HCV non-structural protein 5A inhibitors NS5A inhibitor NS5A inhibitors NS5A replication complex inhibitor NS5A replication complex inhibitors nonstructural protein 5A inhibitors nonstructural protein 5A inhibitor EC 4.2.1.94 (scytalone dehydratase) inhibitor EC 4.2.1.94 (scytalone dehydratase) inhibitors EC 4.2.1.94 inhibitor EC 4.2.1.94 inhibitors scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) inhibitor scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) inhibitors scytalone 7,8-hydro-lyase inhibitor scytalone 7,8-hydro-lyase inhibitors EC 4.2.1.94 (scytalone dehydratase) inhibitor EC 3.4.24.24 (gelatinase A) inhibitor 72 kDa gelatinase inhibitor 72 kDa gelatinase inhibitors 72 kDa gelatinase type A inhibitor 72 kDa gelatinase type A inhibitors EC 3.4.24.35 (gelatinase B) inhibitors EC 3.4.24.35 inhibitor EC 3.4.24.35 inhibitors MMP 2 inhibitor MMP 2 inhibitors collagenase IV inhibitor collagenase IV inhibitors collagenase type IV inhibitor collagenase type IV inhibitors matrix metalloproteinase 2 inhibitor matrix metalloproteinase 2 inhibitors type IV collagen metalloproteinase inhibitor type IV collagen metalloproteinase inhibitors type IV collagenase inhibitor type IV collagenase inhibitors type IV collagenase/gelatinase inhibitor type IV collagenase/gelatinase inhibitors EC 3.4.24.24 (gelatinase A) inhibitor human urinary metabolite human urinary metabolites human urinary metabolite EC 3.5.1.19 (nicotinamidase) inhibitor EC 3.5.1.19 (nicotinamidase) inhibitors EC 3.5.1.19 inhibitor EC 3.5.1.19 inhibitors YNDase inhibitor YNDase inhibitors nicotinamidase (EC 3.5.1.19) inhibitor nicotinamidase (EC 3.5.1.19) inhibitors nicotinamidase inhibitor nicotinamidase inhibitors nicotinamide amidase inhibitor nicotinamide amidase inhibitors nicotinamide amidohydrolase inhibitor nicotinamide amidohydrolase inhibitors nicotinamide deaminase inhibitor nicotinamide deaminase inhibitors EC 3.5.1.19 (nicotinamidase) inhibitor EC 3.4.21.64 (peptidase K) inhibitor EC 3.4.21.64 (peptidase K) inhibitors EC 3.4.21.64 inhibitor EC 3.4.21.64 inhibitors Tritirachium album proteinase K inhibitor Tritirachium album proteinase K inhibitors Tritirachium album serine proteinase inhibitor Tritirachium album serine proteinase inhibitors endopeptidase K inhibitor endopeptidase K inhibitors peptidase K inhibitor peptidase K inhibitors proteinase K inhibitor proteinase K inhibitors EC 3.4.21.64 (peptidase K) inhibitor algal metabolite algal metabolites algal metabolite EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor 2-naphthylamine N-acetyltransferase inhibitor 2-naphthylamine N-acetyltransferase inhibitors 4-aminobiphenyl N-acetyltransferase inhibitor 4-aminobiphenyl N-acetyltransferase inhibitors EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitors EC 2.3.1.5 inhibitor EC 2.3.1.5 inhibitora N-acetyltransferase inhibitor N-acetyltransferase inhibitors acetyl CoA-arylamine N-acetyltransferase inhibitor acetyl CoA-arylamine N-acetyltransferase inhibitors acetyl-CoA:arylamine N-acetyltransferase inhibitor acetyl-CoA:arylamine N-acetyltransferase inhibitors arylamine N-acetyltransferase (EC 2.3.1.5) inhibitor arylamine N-acetyltransferase (EC 2.3.1.5) inhibitors arylamine N-acetyltransferase inhibitor arylamine N-acetyltransferase inhibitors arylamine acetylase inhibitor arylamine acetylase inhibitors arylamine acetyltransferase inhibitor arylamine acetyltransferase inhibitors beta-naphthylamine N-acetyltransferase inhibitor beta-naphthylamine N-acetyltransferase inhibitors indoleamine N-acetyltransferase inhibitor indoleamine N-acetyltransferase inhibitors p-aminosalicylate N-acetyltransferase inhibitor p-aminosalicylate N-acetyltransferase inhibitors serotonin N-acetyltransferase inhibitor serotonin N-acetyltransferase inhibitors serotonin acetyltransferase inhibitor serotonin acetyltransferase inhibitors EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor EC 2.4.1.1 (glycogen phosphorylase) inhibitor (1->4)-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitor (1->4)-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitors 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitor 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitors 1,4-alpha-glucan phosphorylase inhibitor 1,4-alpha-glucan phosphorylase inhibitors EC 2.4.1.1 (glycogen phosphorylase) inhibitors EC 2.4.1.1 inhibitor EC 2.4.1.1 inhibitors alpha-glucan phosphorylase inhibitor alpha-glucan phosphorylase inhibitors amylopectin phosphorylase inhibitor amylopectin phosphorylase inhibitors amylophosphorylase inhibitor amylophosphorylase inhibitors glucan phosphorylase inhibitor glucan phosphorylase inhibitors glucosan phosphorylase inhibitor glucosan phosphorylase inhibitors glycogen phosphorylase (EC 2.4.1.1) inhibitor glycogen phosphorylase (EC 2.4.1.1) inhibitors glycogen phosphorylase inhibitor glycogen phosphorylase inhibitors granulose phosphorylase inhibitor granulose phosphorylase inhibitors maltodextrin phosphorylase inhibitor maltodextrin phosphorylase inhibitors muscle phosphorylase a and b inhibitor muscle phosphorylase a and b inhibitors muscle phosphorylase inhibitor muscle phosphorylase inhibitors myophosphorylase inhibitor myophosphorylase inhibitors phosphorylase inhibitor phosphorylase inhibitors polyphosphorylase inhibitor polyphosphorylase inhibitors potato phosphorylase inhibitor potato phosphorylase inhibitors starch phosphorylase inhibitor starch phosphorylase inhibitors EC 2.4.1.1 (glycogen phosphorylase) inhibitor EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor 1D-myo-inositol-trisphosphate 3-kinase inhibitor 1D-myo-inositol-trisphosphate 3-kinase inhibitors ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase inhibitor ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase inhibitors EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitors EC 2.7.1.127 inhibitor EC 2.7.1.127 inhibitors IP3 3-kinase inhibitor IP3 3-kinase inhibitors IP3K inhibitor IP3K inhibitors Ins(1,4,5)P3 3-kinase inhibitor Ins(1,4,5)P3 3-kinase inhibitors inositol 1,4,5-trisphosphate 3-kinase inhibitor inositol 1,4,5-trisphosphate 3-kinase inhibitors inositol-trisphosphate 3-kinase (EC 2.7.1.127) inhibitor inositol-trisphosphate 3-kinase (EC 2.7.1.127) inhibitors inositol-trisphosphate 3-kinase inhibitor inositol-trisphosphate 3-kinase inhibitors EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase inhibitor ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase inhibitors ArgRIII inhibitor ArgRIII inhibitors AtIpk2alpha inhibitor AtIpk2alpha inhibitors AtIpk2beta inhibitor AtIpk2beta inhibitors EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitors EC 2.7.1.151 inhibitor EC 2.7.1.151 inhibitors IP3/IP4 6-/3-kinase inhibitor IP3/IP4 6-/3-kinase inhibitors IP3/IP4 dual-specificity 6-/3-kinase inhibitor IP3/IP4 dual-specificity 6-/3-kinase inhibitors IpK2 inhibitor IpK2 inhibitors IpmK inhibitor IpmK inhibitors inositol polyphosphate 6-/3-/5-kinase inhibitor inositol polyphosphate 6-/3-/5-kinase inhibitors inositol-polyphosphate multikinase (EC 2.7.1.151) inhibitor inositol-polyphosphate multikinase (EC 2.7.1.151) inhibitors inositol-polyphosphate multikinase inhibitor inositol-polyphosphate multikinase inhibitors EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitor EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitors EC 2.7.4.* inhibitor EC 2.7.4.* inhibitors phosphotransferases with a phosphate group as acceptor (EC 2.7.4.*) inhibitor phosphotransferases with a phosphate group as acceptor (EC 2.7.4.*) inhibitors EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitor EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor ATP:nucleoside-diphosphate phosphotransferase inhibitor ATP:nucleoside-diphosphate phosphotransferase inhibitors EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitors EC 2.7.4.6 inhibitor EC 2.7.4.6 inhibitors UDP kinase inhibitor UDP kinase inhibitors nucleoside 5'-diphosphate kinase inhibitor nucleoside 5'-diphosphate kinase inhibitors nucleoside diphosphate (UDP) kinase inhibitor nucleoside diphosphate (UDP) kinase inhibitors nucleoside diphosphokinase inhibitor nucleoside diphosphokinase inhibitors nucleoside-diphosphate kinase (EC 2.7.4.6) inhibitor nucleoside-diphosphate kinase (EC 2.7.4.6) inhibitors nucleoside-diphosphate kinase inhibitor nucleoside-diphosphate kinase inhibitors nucleotide phosphate kinase inhibitor nucleotide phosphate kinase inhibitors uridine diphosphate kinase inhibitor uridine diphosphate kinase inhibitors EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor EC 2.6.1.16 (glutamine--fructose-6-phosphate transaminase (isomerizing)) inhibitor D-fructose-6-phosphate amidotransferase inhibitor D-fructose-6-phosphate amidotransferase inhibitors EC 2.6.1.16 (glutamine--fructose-6-phosphate transaminase (isomerizing)) inhibitors EC 2.6.1.16 inhibitor EC 2.6.1.16 inhibitors GlcN6P synthase inhibitor GlcN6P synthase inhibitors L-glutamine-D-fructose-6-phosphate amidotransferase inhibitor L-glutamine-D-fructose-6-phosphate amidotransferase inhibitors L-glutamine:D-fructose-6-phosphate isomerase (deaminating) inhibitor L-glutamine:D-fructose-6-phosphate isomerase (deaminating) inhibitors glucosamine 6-phosphate synthase inhibitor glucosamine 6-phosphate synthase inhibitors glucosamine-6-phosphate isomerase (glutamine-forming) inhibitor glucosamine-6-phosphate isomerase (glutamine-forming) inhibitors glucosamine-6-phosphate synthase inhibitor glucosamine-6-phosphate synthase inhibitors glucosaminephosphate isomerase inhibitor glucosaminephosphate isomerase inhibitors hexosephosphate aminotransferase inhibitor hexosephosphate aminotransferase inhibitors EC 2.6.1.16 (glutamine--fructose-6-phosphate transaminase (isomerizing)) inhibitor thrombopoietin receptor agonist TPO receptor agonist TPO receptor agonists thrombopoietin receptor agonists thrombopoietin receptor agonist skin lightening agent melanogenesis inhibitor melanogenesis inhibitors skin bleaching agent skin bleaching agents skin depigmenting agent skin depigmenting agents skin lightening agents skin whitening agent skin whitening agents skin lightening agent EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitors EC 1.10.3.* inhibitor EC 1.10.3.* inhibitors EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor EC 1.10.3.1 (catechol oxidase) inhibitor 1,2-benzenediol:oxygen oxidoreductase inhibitor 1,2-benzenediol:oxygen oxidoreductase inhibitors Dopa oxidase inhibitor Dopa oxidase inhibitors EC 1.10.3.1 (catechol oxidase) inhibitors EC 1.10.3.1 inhibitor EC 1.10.3.1 inhibitors catechol oxidase (EC 1.10.3.1) inhibitor catechol oxidase (EC 1.10.3.1) inhibitors catechol oxidase inhibitor catechol oxidase inhibitors catecholase inhibitor catecholase inhibitors diphenol oxidase inhibitor diphenol oxidase inhibitors o-diphenol oxidoreductase inhibitor o-diphenol oxidoreductase inhibitors o-diphenol:oxygen oxidoreductase inhibitor o-diphenol:oxygen oxidoreductase inhibitors o-diphenolase inhibitor o-diphenolase inhibitors phenolase inhibitor phenolase inhibitors polyphenol oxidase inhibitor polyphenol oxidase inhibitors pyrocatechol oxidase inhibitor pyrocatechol oxidase inhibitors tyrosinase inhibitor tyrosinase inhibitors EC 1.10.3.1 (catechol oxidase) inhibitor EC 1.10.3.2 (laccase) inhibitor EC 1.10.3.2 (laccase) inhibitors EC 1.10.3.2 inhibitor EC 1.10.3.2 inhibitors benzenediol:oxygen oxidoreductase inhibitor benzenediol:oxygen oxidoreductase inhibitors laccase (EC 1.10.3.2) inhibitor laccase (EC 1.10.3.2) inhibitors laccase inhibitor laccase inhibitors p-diphenol oxidase inhibitor p-diphenol oxidase inhibitors urishiol oxidase inhibitor urishiol oxidase inhibitors urushiol oxidase inhibitor urushiol oxidase inhibitors EC 1.10.3.2 (laccase) inhibitor EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitors EC 1.13.11.24 inhibitor EC 1.13.11.24 inhibitors flavonol 2,4-oxygenase inhibitor flavonol 2,4-oxygenase inhibitors quercetin 2,3-dioxygenase (EC 1.13.11.24) inhibitor quercetin 2,3-dioxygenase (EC 1.13.11.24) inhibitors quercetin 2,3-dioxygenase inhibitor quercetin 2,3-dioxygenase inhibitors quercetin:oxygen 2,3-oxidoreductase (decyclising) inhibitor quercetin:oxygen 2,3-oxidoreductase (decyclising) inhibitors quercetin:oxygen 2,3-oxidoreductase (decyclizing) inhibitor quercetin:oxygen 2,3-oxidoreductase (decyclizing) inhibitors quercetin:oxygen 2,3-oxidoreductase (ring-opening) inhibitor quercetin:oxygen 2,3-oxidoreductase (ring-opening) inhibitors quercetinase inhibitor quercetinase inhibitors EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor EC 1.4.3.3 (D-amino-acid oxidase) inhibitor D-amino-acid oxidase (EC 1.4.3.3) inhibitor D-amino-acid oxidase (EC 1.4.3.3) inhibitors D-amino-acid oxidase inhibitor D-amino-acid oxidase inhibitors D-amino-acid:oxygen oxidoreductase (deaminating) inhibitor D-amino-acid:oxygen oxidoreductase (deaminating) inhibitors EC 1.4.3.3 (D-amino-acid oxidase) inhibitors EC 1.4.3.3 inhibitor EC 1.4.3.3 inhibitors L-amino acid:O2 oxidoreductase inhibitor L-amino acid:O2 oxidoreductase inhibitors new yellow enzyme inhibitor new yellow enzyme inhibitors ophio-amino-acid oxidase inhibitor ophio-amino-acid oxidase inhibitors EC 1.4.3.3 (D-amino-acid oxidase) inhibitor EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activator 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activators 3-hydroxy-3-methylglutaryl-CoA reductase kinase activator 3-hydroxy-3-methylglutaryl-CoA reductase kinase activators AMP-activated protein kinase activator AMP-activated protein kinase activators AMPK activator AMPK activators ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase activator ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase activators EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) activator EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) activators EC 2.7.11.31 activator EC 2.7.11.31 activators EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activators HMG-CoA reductase kinase activator HMG-CoA reductase kinase activators STK29 activator STK29 activators [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activator [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activators [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase activator [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase activators beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activator beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activators hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activator hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activators hydroxymethylglutaryl coenzyme A reductase kinase activator hydroxymethylglutaryl coenzyme A reductase kinase activators hydroxymethylglutaryl-CoA reductase kinase activator hydroxymethylglutaryl-CoA reductase kinase activators reductase kinase activator reductase kinase activators EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor ATP:protein phosphotransferase (cAMP-dependent) inhibitor ATP:protein phosphotransferase (cAMP-dependent) inhibitors EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitors EC 2.7.11.11 inhibitor EC 2.7.11.11 inhibitors PKA C inhibitor PKA C inhibitors PKA inhibitor PKA inhibitors STK22 inhibitor inhibitor STK22 inhibitors inhibitors cAMP-dependent protein kinase (EC 2.7.11.11) inhibitor cAMP-dependent protein kinase (EC 2.7.11.11) inhibitors cAMP-dependent protein kinase inhibitor cAMP-dependent protein kinase inhibitors protein kinase A inhibitor protein kinase A inhibitors EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 3':5'-cyclic GMP-dependent protein kinase inhibitor 3':5'-cyclic GMP-dependent protein kinase inhibitors ATP:protein phosphotransferase (cGMP-dependent) inhibitor ATP:protein phosphotransferase (cGMP-dependent) inhibitors EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitors EC 2.7.11.12 inhibitor EC 2.7.11.12 inhibitors PKG 1alpha inhibitor PKG 1alpha inhibitors PKG 1beta inhibitor PKG 1beta inhibitors PKG II inhibitor PKG II inhibitors PKG inhibitor PKG inhibitors STK23 inhibitor STK23 inhibitors cGMP-dependent protein kinase (EC 2.7.11.12) inhibitor cGMP-dependent protein kinase (EC 2.7.11.12) inhibitors cGMP-dependent protein kinase Ibeta inhibitor cGMP-dependent protein kinase Ibeta inhibitors cGMP-dependent protein kinase inhibitor cGMP-dependent protein kinase inhibitors guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitor guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitors EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor nonnucleoside hepatitis C virus polymerase inhibitor NS5B inhibitor NS5B inhibitors nonnucleoside hepatitis C virus polymerase inhibitors nonstructural protein 5B inhibitor nonstructural protein 5B inhibitors nonnucleoside hepatitis C virus polymerase inhibitor hepatitis C virus nonstructural protein 5A inhibitor NS5A inhibitor NS5A inhibitors hepatitis C virus nonstructural protein 5A inhibitors nonstructural protein 5A inhibitor nonstructural protein 5A inhibitors hepatitis C virus nonstructural protein 5A inhibitor human blood serum metabolite human blood serum metabolites human blood serum metabolite GABA reuptake inhibitor GABA re-uptake inhibitor GABA re-uptake inhibitors GABA reuptake inhibitors gamma-aminobutyric acid re-uptake inhibitor gamma-aminobutyric acid re-uptake inhibitors gamma-aminobutyric acid reuptake inhibitor gamma-aminobutyric acid reuptake inhibitors GABA reuptake inhibitor glycine transporter 2 inhibitor GlyT2 inhibitor GlyT2 inhibitors glycine transporter 2 inhibitors glycine transporter 2 inhibitor glycine transporter inhibitor glycine transporter inhibitors glycine transporter inhibitor thromboxane A2 antagonist TXA2/PGH2 antagonist TXA2/PGH2 antagonists TXA2/PGH2 receptor antagonist TXA2/PGH2 receptor antagonists thromboxane A2 antagonists thromboxane A2 receptor antagonist thromboxane A2 receptor antagonists thromboxane A2 antagonist EC 2.5.1.31 {ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]} inhibitor (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 8 isopentenyl units) inhibitor (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 8 isopentenyl units) inhibitors EC 2.5.1.31 inhibitor EC 2.5.1.31 inhibitors EC 2.5.1.31 {ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]} inhibitors UPP synthetase inhibitor UPP synthetase inhibitors bactoprenyl-diphosphate synthase inhibitor bactoprenyl-diphosphate synthase inhibitors ditrans,polycis-undecaprenyl-diphosphate synthase inhibitor ditrans,polycis-undecaprenyl-diphosphate synthase inhibitors ditrans,polycis-undecaprenylcistransferase inhibitor ditrans,polycis-undecaprenylcistransferase inhibitors undecaprenyl diphosphate synthetase inhibitor undecaprenyl diphosphate synthetase inhibitors undecaprenyl pyrophosphate synthase inhibitor undecaprenyl pyrophosphate synthase inhibitors undecaprenyl pyrophosphate synthetase inhibitor undecaprenyl pyrophosphate synthetase inhibitors undecaprenyl-diphosphate synthase inhibitor undecaprenyl-diphosphate synthase inhibitors EC 2.5.1.31 {ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]} inhibitor EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitor EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group with NAD(+) or NADP(+) as acceptor) inhibitor EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group with NAD(+) or NADP(+) as acceptor) inhibitors EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitors EC 1.4.1.* inhibitor EC 1.4.1.* inhibitors EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitor EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitor EC 1.4.1.3 inhibitor EC 1.4.1.3 inhibitors EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitors L-glutamate:NAD(P)(+) oxidoreductase (deaminating) inhibitor L-glutamate:NAD(P)(+) oxidoreductase (deaminating) inhibitors glutamate dehydrogenase [NAD(P)(+)] (EC 1.4.1.3) inhibitor glutamate dehydrogenase [NAD(P)(+)] (EC 1.4.1.3) inhibitors glutamate dehydrogenase [NAD(P)(+)] inhibitor glutamate dehydrogenase [NAD(P)(+)] inhibitors glutamic dehydrogenase inhibitor glutamic dehydrogenase inhibitors EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitor liver X receptor agonist LXR agonist LXR agonists liver X receptor agonists liver X receptor agonist rat metabolite Rattus norvegicus metabolite Rattus norvegicus metabolites rat metabolites rat metabolite antifungal drug anti-fungal drug anti-fungal drugs anti-fungal medication anti-fungal medications antifungal drugs antifungal medication antifungal medications pharmaceutical fungicide pharmaceutical fungicides antifungal drug antifungal agrochemical agrichemical fungicide agrichemical fungicides agrochemical fungicide agrochemical fungicides anti-fungal agrichemical anti-fungal agrichemicals anti-fungal agrochemical anti-fungal agrochemicals antifungal agrichemical antifungal agrichemicals antifungal agrochemicals antifungal agrochemical EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitors EC 5.3.3.* inhibitor EC 5.3.3.* inhibitors intramolecular oxidase transposing C=C bonds inhibitor (EC 5.3.3.*) inhibitor intramolecular oxidase transposing C=C bonds inhibitor (EC 5.3.3.*) inhibitors EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitor Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitors EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitors EC 5.3.3.5 inhibitor EC 5.3.3.5 inhibitors cholestenol Delta-isomerase (EC 5.3.3.5) inhibitor cholestenol Delta-isomerase (EC 5.3.3.5) inhibitors EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor EC 1.14.13.78 (ent-kaurene oxidase) inhibitor EC 1.14.13.78 (ent-kaurene oxidase) inhibitors EC 1.14.13.78 inhibitor EC 1.14.13.78 inhibitors ent-kaurene oxidase (EC 1.14.13.78) inhibitor ent-kaurene oxidase (EC 1.14.13.78) inhibitors EC 1.14.13.78 (ent-kaurene oxidase) inhibitor EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor CYP3A4 inhibitor CYP3A4 inhibitors CYP4A21 inhibitor CYP4A21 inhibitors EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitors EC 1.14.13.97 inhibitor EC 1.14.13.97 inhibitors cytochrome P450 3A4 inhibitor cytochrome P450 3A4 inhibitors taurochenodeoxycholate 6alpha-hydroxylase inhibitor taurochenodeoxycholate 6alpha-hydroxylase inhibitors taurochenodeoxycholate 6alpha-monooxygenase inhibitor taurochenodeoxycholate 6alpha-monooxygenase inhibitors taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) inhibitor taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) inhibitors EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor EC 3.4.21.92 (endopeptidase Clp) inhibitor ATP-dependent Clp protease inhibitor ATP-dependent Clp protease inhibitors Clp protease inhibitor Clp protease inhibitors ClpP inhibitor ClpP inhibitors EC 3.4.21.92 (endopeptidase Clp) inhibitors EC 3.4.21.92 inhibitor EC 3.4.21.92 inhibitors caseinolytic protease inhibitor caseinolytic protease inhibitors endopeptidase Ti inhibitor endopeptidase Ti inhibitors protease Ti inhibitor protease Ti inhibitors EC 3.4.21.92 (endopeptidase Clp) inhibitor STAT3 inhibitor STAT3 inhibitors signal transducer and activator of transcription 3 inhibitor signal transducer and activator of transcription 3 inhibitors STAT3 inhibitor Smad3 inhibitor Mothers against decapentaplegic homolog 3 inhibitors Mothers against decapentaplegic homologue 3 inhibitor Mothers against decapentaplegic homologue 3 inhibitors SMAD family member 3 inhibitor SMAD family member 3 inhibitors SMAD3 inhibitors Smad3 inhibitor Smad3 inhibitors mothers against decapentaplegic homolog 3 inhibitor Smad3 inhibitor signal transducer and activator of transcription 5 protein inhibitor STAT5 inhibitor STAT5 inhibitors signal transducer and activator of transcription 5 protein inhibitors signal transducer and activator of transcription 5 protein inhibitor cyanotoxin cyanotoxins cyanotoxin drug allergen allergenic drug drug allergen potassium ionophore potassium ionophores potassium ionophore autophagy inhibitor autophagocytosis inhibitor autophagocytosis inhibitors autophagy inhibitors autophagy inhibitor EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitors EC 2.7.12.* inhibitor EC 2.7.12.* inhibitors inhibitor of dual-specificity kinases (those acting on Ser/Thr and Tyr residues) (EC 2.7.12.*) inhibitors of dual-specificity kinases (those acting on Ser/Thr and Tyr residues) (EC 2.7.12.*) EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor ATP:protein phosphotransferase (MAPKKK-activated) inhibitor ATP:protein phosphotransferase (MAPKKK-activated) inhibitors EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitors EC 2.7.12.2 inhibitor EC 2.7.12.2 inhibitors MAP kinase kinase 4 inhibitor MAP kinase kinase 4 inhibitors MAP kinase kinase 7 inhibitor MAP kinase kinase 7 inhibitors MAP kinase kinase inhibitor MAP kinase kinase inhibitors MAP kinase or ERK kinase inhibitor MAP kinase or ERK kinase inhibitors MAP2K inhibitor MAP2K inhibitors MAPKK inhibitor MAPKK inhibitors MAPKK1 inhibitor MAPKK1 inhibitors MEK inhibitor MEK inhibitors MEK1 inhibitor MEK1 inhibitors MEK2 inhibitor MEK2 inhibitors MKK inhibitor MKK inhibitors MKK2 inhibitor MKK2 inhibitors MKK4 inhibitor MKK4 inhibitors MKK6 inhibitor MKK6 inhibitors MKK7 inhibitor MKK7 inhibitors STK27 inhibitor STK27 inhibitors mitogen-activated protein kinase kinase (EC 2.7.12.2) inhibitor mitogen-activated protein kinase kinase (EC 2.7.12.2) inhibitors mitogen-activated protein kinase kinase inhibitor mitogen-activated protein kinase kinase inhibitors EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor G-protein-coupled receptor antagonist G-protein-coupled receptor antagonists GPCR antagonist GPCR antagonists G-protein-coupled receptor antagonist retinoic acid receptor gamma agonist NR1B3 agonist NR1B3 agonists RARgamma agonist RARgamma agonists nuclear receptor subfamily 1, group B, member 3 agonist nuclear receptor subfamily 1, group B, member 3 agonists retinoic acid receptor gamma agonists retinoic acid receptor gamma agonist alpha-secretase activator alpha-secretase activators alpha-secretase activator EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitor 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitor 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitors 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitor 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitors 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase inhibitor 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase inhibitors 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) inhibitor 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) inhibitors 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitor 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitors 3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)(+) 3-oxidoreductase (decarboxylating) inhibitor 3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)(+) 3-oxidoreductase (decarboxylating) inhibitors EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitors EC 1.1.1.170 inhibitor EC 1.1.1.170 inhibitors sterol 4alpha-carboxylic decarboxylase inhibitor sterol 4alpha-carboxylic decarboxylase inhibitors sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitor sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitors EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitor c-Jun N-terminal kinase inhibitor JNK inhibitor JNK inhibitors c-Jun N-terminal kinase inhibitors c-Jun N-terminal kinase inhibitor EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor DNA 5-cytosine methylase inhibitor DNA 5-cytosine methylase inhibitors DNA cytosine c(5) methylase inhibitor DNA cytosine c(5) methylase inhibitors DNA cytosine methylase inhibitor DNA cytosine methylase inhibitors DNA methylase inhibitor DNA methylase inhibitors DNA methyltransferase inhibitor DNA methyltransferase inhibitors DNA transmethylase inhibitor DNA transmethylase inhibitors DNA-cytosine 5-methylase inhibitor DNA-cytosine 5-methylase inhibitors DNA-cytosine methyltransferase inhibitor DNA-cytosine methyltransferase inhibitors EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitors EC 2.1.1.37 inhibitor EC 2.1.1.37 inhibitors EcoRI methylase inhibitor EcoRI methylase inhibitors HpaII methylase inhibitor HpaII methylase inhibitors HpaII' methylase inhibitor HpaII' methylase inhibitors M.BsuRIa inhibitor M.BsuRIa inhibitors M.BsuRIb inhibitor M.BsuRIb inhibitors S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase inhibitor S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase inhibitors Typ II DNA methylase inhibitor Typ II DNA methylase inhibitors cytosine 5-methyltransferase inhibitor cytosine 5-methyltransferase inhibitors cytosine DNA methylase inhibitors cytosine DNA methyltransferase inhibitor cytosine DNA methyltransferase inhibitors cytosine-specific DNA methyltransferase inhibitor cytosine-specific DNA methyltransferase inhibitors deoxyribonucleate methylase inhibitor deoxyribonucleate methylase inhibitors deoxyribonucleate methyltransferase inhibitor deoxyribonucleate methyltransferase inhibitors deoxyribonucleic (cytosine-5-)-methyltransferase inhibitor deoxyribonucleic (cytosine-5-)-methyltransferase inhibitors deoxyribonucleic acid (cytosine-5-)-methyltransferase inhibitor deoxyribonucleic acid (cytosine-5-)-methyltransferase inhibitors deoxyribonucleic acid methylase inhibitor deoxyribonucleic acid methylase inhibitors deoxyribonucleic acid methyltransferase inhibitor deoxyribonucleic acid methyltransferase inhibitors deoxyribonucleic acid modification methylase inhibitor deoxyribonucleic acid modification methylase inhibitors deoxyribonucleic methylase inhibitor deoxyribonucleic methylase inhibitors methylphosphotriester-DNA methyltransferase inhibitor methylphosphotriester-DNA methyltransferase inhibitors modification methylase inhibitor modification methylase inhibitors restriction-modification system inhibitor restriction-modification system inhibitors site-specific DNA-methyltransferase (cytosine-specific) inhibitor site-specific DNA-methyltransferase (cytosine-specific) inhibitors EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor c-Met tyrosine kinase inhibitor MET inhibitor MET inhibitors MET proto-oncogene, receptor tyrosine kinase inhibitor MET proto-oncogene, receptor tyrosine kinase inhibitors c-Met inhibitor c-Met inhibitors c-Met tyrosine kinase inhibitors c-Met tyrosine kinase inhibitor EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitors EC 4.1.1.23 inhibitor EC 4.1.1.23 inhibitors ODCase inhibitor ODCase inhibitors OMP decarboxylase inhibitor OMP decarboxylase inhibitors OMP-DC inhibitor OMP-DC inhibitors OMPdcase inhibitor OMPdcase inhibitors UMP synthase inhibitor UMP synthase inhibitors orotate decarboxylase inhibitor orotate decarboxylase inhibitors orotate monophosphate decarboxylase inhibitor orotate monophosphate decarboxylase inhibitors orotic decarboxylase inhibitor orotic decarboxylase inhibitors orotidine 5'-phosphate decarboxylase inhibitor orotidine 5'-phosphate decarboxylase inhibitors orotidine monophosphate decarboxylase inhibitor orotidine monophosphate decarboxylase inhibitors orotidine phosphate decarboxylase inhibitor orotidine phosphate decarboxylase inhibitors orotidine-5'-monophosphate decarboxylase inhibitor orotidine-5'-monophosphate decarboxylase inhibitors orotidine-5'-phosphate carboxy-lyase (UMP-forming) inhibitor orotidine-5'-phosphate carboxy-lyase (UMP-forming) inhibitors orotidine-5'-phosphate carboxy-lyase inhibitor orotidine-5'-phosphate carboxy-lyase inhibitors orotidine-5'-phosphate decarboxylase (EC 4.1.1.23) inhibitor orotidine-5'-phosphate decarboxylase (EC 4.1.1.23) inhibitors orotidylic acid decarboxylase inhibitor orotidylic acid decarboxylase inhibitors orotidylic decarboxylase inhibitor orotidylic decarboxylase inhibitors orotodylate decarboxylase inhibitor orotodylate decarboxylase inhibitors uridine 5'-monophosphate synthase inhibitor uridine 5'-monophosphate synthase inhibitors EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor EC 6.4.1.1 (pyruvate carboxylase) inhibitor EC 6.4.1.1 (pyruvate carboxylase) inhibitors EC 6.4.1.1 inhibitor EC 6.4.1.1 inhibitors pyruvate carboxylase (EC 6.4.1.1) inhibitor pyruvate carboxylase (EC 6.4.1.1) inhibitors pyruvate carboxylase inhibitor pyruvate carboxylase inhibitors pyruvate:carbon-dioxide ligase (ADP-forming) inhibitor pyruvate:carbon-dioxide ligase (ADP-forming) inhibitors pyruvic carboxylase inhibitor pyruvic carboxylase inhibitors EC 6.4.1.1 (pyruvate carboxylase) inhibitor EC 4.6.1.1 (adenylate cyclase) inhibitor 3',5'-cyclic AMP synthetase inhibitor 3',5'-cyclic AMP synthetase inhibitors ATP diphosphate-lyase (cyclising) inhibitor ATP diphosphate-lyase (cyclising) inhibitors ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitor ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitors ATP diphosphate-lyase (cyclizing) inhibitor ATP diphosphate-lyase (cyclizing) inhibitors ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitor ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitors ATP pyrophosphate-lyase inhibitor ATP pyrophosphate-lyase inhibitors EC 4.6.1.1 (adenylate cyclase) inhibitors EC 4.6.1.1 inhibitor EC 4.6.1.1 inhibitors adenyl cyclase inhibitor adenylate cyclase (EC 4.6.1.1) inhibitor adenylate cyclase (EC 4.6.1.1) inhibitors adenylate cyclase inhibitor adenylate cyclase inhibitors adenylyl cyclase inhibitor adenylyl cyclase inhibitors adenylylcyclase inhibitor adenylylcyclase inhibitors EC 4.6.1.1 (adenylate cyclase) inhibitor histone acetyltransferase activator HAT activator HAT activators histone acetyltransferase activators histone acetyltransferase activator Sir1 inhibitor SIRT1 inhibitor SIRT1 inhibitors Sir1 inhibitors sirtuin 1 inhibitor sirtuin 1 inhibitors Sir1 inhibitor secretagogue secretagogues secretagogue insulin secretagogue insulin secretagogues insulin secretagogue EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor EC 5.3.1.1 (triose-phosphate isomerase) inhibitor D-glyceraldehyde-3-phosphate ketol-isomerase inhibitor D-glyceraldehyde-3-phosphate ketol-isomerase inhibitors EC 5.3.1.1 (triose-phosphate isomerase) inhibitors EC 5.3.1.1 inhibitor EC 5.3.1.1 inhibitors phosphotriose isomerase inhibitor phosphotriose isomerase inhibitors triose phosphate mutase inhibitor triose phosphate mutase inhibitors triose phosphoisomerase inhibitor triose phosphoisomerase inhibitors triose-phosphate isomerase (EC 5.3.1.1) inhibitor triose-phosphate isomerase (EC 5.3.1.1) inhibitors triose-phosphate isomerase inhibitor triose-phosphate isomerase inhibitors triosephosphate isomerase inhibitor triosephosphate isomerase inhibitors triosephosphate mutase inhibitor triosephosphate mutase inhibitors EC 5.3.1.1 (triose-phosphate isomerase) inhibitor retinoic acid receptor modulator retinoic acid receptor modulators retinoic acid receptor modulator nuclear receptor modulator nuclear receptor modulators nuclear receptor modulator receptor modulator receptor modulators receptor modulator retinoic acid receptor alpha antagonist RAR alpha antagonist RAR alpha antagonists RARalpha antagonist RARalpha antagonists retinoic acid receptor alpha antagonists retinoic acid receptor alpha antagonist retinoic acid receptor antagonist RAR antagonist RAR antagonists retinoic acid receptor antagonists retinoic acid receptor antagonist retinoic acid receptor beta agonist RAR beta agonist RAR beta agonists RARbeta agonist RARbeta agonists retinoic acid receptor beta agonists retinoic acid receptor beta agonist retinoic acid receptor gamma antagonist RAR gamma antagonist RAR gamma antagonists RARgamma antagonist RARgamma antagonists retinoic acid receptor gamma antagonists retinoic acid receptor gamma antagonist antidote to cyanide poisoning antidote to cyanide poisoning antidote to organophosphate poisoning antidote to acetylcholinesterase inhibitor poisoning antidote to nerve agents antidote to organophosphate poisoning antidote to opioid poisoning antidote to opioid overdose antidote to opioid poisoning antidote to benzodiazepine poisoning antidote to benzodiazepine overdose antidote to benzodiazepine poisoning eukaryotic translation elongation factor 1alpha 1 inhibitor EEF1A1 inhibitor EEF1A1 inhibitors eEF1A inhibitor eEF1A inhibitors eukaryotic translation elongation factor 1alpha 1 inhibitors eukaryotic translation elongation factor 1alpha 1 inhibitor AKT1 kinase inhibitor AKT1 kinase inhibitors RAC-alpha serine/threonine-protein kinase inhibitor RAC-alpha serine/threonine-protein kinase inhibitors AKT1 kinase inhibitor prostacyclin receptor agonist IP receptor agonist IP receptor agonists IP1 agonist IP1 agonists prostacyclin receptor I2 agonist prostacyclin receptor I2 agonists prostacyclin receptor agonists prostacyclin receptor agonist liver X receptor inverse agonist LXR inverse agonist LXR inverse agonists liver X receptor inverse agonists liver X receptor inverse agonist inverse agonist inverse agonists inverse agonist EC 2.4.2.4 (thymidine phosphorylase) inhibitor EC 2.4.2.4 (thymidine phosphorylase) inhibitors EC 2.4.2.4 inhibitor EC 2.4.2.4 inhibitors deoxythymidine phosphorylase inhibitor deoxythymidine phosphorylase inhibitors pyrimidine deoxynucleoside phosphorylase inhibitor pyrimidine deoxynucleoside phosphorylase inhibitors pyrimidine phosphorylase inhibitor pyrimidine phosphorylase inhibitors thymidine phosphorylase inhibitor thymidine phosphorylase inhibitors thymidine-orthophosphate deoxyribosyltransferase inhibitor thymidine-orthophosphate deoxyribosyltransferase inhibitors thymidine:phosphate deoxy-D-ribosyltransferase inhibitor thymidine:phosphate deoxy-D-ribosyltransferase inhibitors thymidine:phosphate deoxy-alpha-D-ribosyltransferase inhibitor thymidine:phosphate deoxy-alpha-D-ribosyltransferase inhibitors EC 2.4.2.4 (thymidine phosphorylase) inhibitor EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitor EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitors EC 1.8.5.* inhibitor EC 1.8.5.* inhibitors oxidoreductase acting on sulfur group donors, quinone or similar as acceptor (EC 1.8.5.*) inhibitor oxidoreductase acting on sulfur group donors, quinone or similar as acceptor (EC 1.8.5.*) inhibitors EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitor EC 1.8.5.4 (sulfide:quinone reductase) inhibitor EC 1.8.5.4 (sulfide:quinone reductase) inhibitors EC 1.8.5.4 inhibitor EC 1.8.5.4 inhibitors sulfide:quinone oxidoreductase inhibitor sulfide:quinone oxidoreductase inhibitors sulfide:quinone reductase (EC 1.8.5.4) inhibitor sulfide:quinone reductase (EC 1.8.5.4) inhibitors sulfide:quinone reductase inhibitor sulfide:quinone reductase inhibitors EC 1.8.5.4 (sulfide:quinone reductase) inhibitor ERK dimerisation inhibitor ERK dimerisation inhibitors extracellular signal-regulated kinase dimerisation inhibitor extracellular signal-regulated kinase dimerisation inhibitors ERK dimerisation inhibitor steroid receptor coactivator stimulator SRC stimulator SRC stimulators steroid receptor coactivator small molecule stimulator steroid receptor coactivator small molecule stimulators steroid receptor coactivator stimulators steroid receptor coactivator stimulator corrosion inhibitor corrosion inhibitors corrosion inhibitor GABAA receptor agonist GABAA receptor agonists GABAA receptor agonist erythropoietin inhibitor EPO inhibitor EPO inhibitors erythropoietin inhibitors erythropoietin inhibitor purinergic receptor P2 antagonist P2 antagonist P2 antagonists non-selective P2 purinergic antagonist non-selective P2 purinergic antagonists purinergic receptor P2 antagonists purinergic receptor P2 antagonist purinergic receptor P2X antagonist P2X antagonist P2X antagonists purinergic receptor P2X antagonists purinergic receptor P2X antagonist collagen cross-linking inhibitor collagen cross-linking inhibitors collagen cross-linking inhibitor EC 2.7.11.26 (tau-protein kinase) inhibitor ATP:[tau-protein] O-phosphotransferase inhibitor ATP:[tau-protein] O-phosphotransferase inhibitors ATP:tau-protein O-phosphotransferase inhibitor ATP:tau-protein O-phosphotransferase inhibitors CDK5/p23 inhibitor CDK5/p23 inhibitors EC 2.7.11.26 (tau-protein kinase) inhibitors EC 2.7.11.26 inhibitor EC 2.7.11.26 inhibitors GSK inhibitor GSK inhibitors GSK-3 inhibitor GSK-3 inhibitors STK31 inhibitor STK31 inhibitors TPK I inhibitor TPK I inhibitors TPK II inhibitor TPK II inhibitors TPK inhibitor TPK inhibitors TTK inhibitor TTK inhibitors [tau-protein] kinase inhibitor [tau-protein] kinase inhibitors brain protein kinase PK40erk inhibitor brain protein kinase PK40erk inhibitors cdk5/p20 inhibitor cdk5/p20 inhibitors glycogen synthase kinase-3beta inhibitor glycogen synthase kinase-3beta inhibitors protein tau kinase inhibitor protein tau kinase inhibitors tau kinase inhibitor tau kinase inhibitors tau-protein kinase I inhibitor tau-protein kinase I inhibitors tau-protein kinase II inhibitor tau-protein kinase II inhibitors tau-tubulin inhibitor tau-tubulin inhibitors EC 2.7.11.26 (tau-protein kinase) inhibitor elastin-laminin receptor agonist ELR agonist ELR agonists elastin-laminin receptor agonists elastin-laminin receptor agonist EC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitor EC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitors EC 1.1.5.3 inhibitor EC 1.1.5.3 inhibitors glycerol-3-phosphate dehydrogenase inhibitor glycerol-3-phosphate dehydrogenase inhibitors EC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitor EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or simliar compound as acceptor) inhibitors EC 1.1.5.* inhibitor EC 1.1.5.* inhibitors oxidoreductase acting on donor CH-OH group, quinone or simliar compound as acceptor (EC 1.1.5.*) inhibitor oxidoreductase acting on donor CH-OH group, quinone or simliar compound as acceptor (EC 1.1.5.*) inhibitors EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor VEGF activator VEGF activators VEGF inducer VEGF inducers vascular endothelial growth factor activator vascular endothelial growth factor activators vascular endothelial growth factor inducer vascular endothelial growth factor inducers VEGF activator lysophosphatidic acid receptor antagonist LPA receptor antagonist LPA receptor antagonists LPAR antagonist LPAR antagonists lysophosphatidic acid receptor antagonists lysophosphatidic acid receptor antagonist TGFbeta receptor antagonist TGFR antagonist TGFR antagonists TGFbeta receptor antagonists transforming growth factor receptor antagonist transforming growth factor receptor antagonists TGFbeta receptor antagonist macrophage migration inhibitory factor inhibitor MIF inhibitor MIF inhibitors macrophage migration inhibitory factor inhibitors macrophage migration inhibitory factor inhibitor tienilic acid (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid Thienylic acid Ticrynafen [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid acide tienilique acido tienilico acidum tienilicum tienilic acid tienilic acid cell line cell A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture Yongqun He, Matthew Brush, Sirarat Sarntivijai, Alexander Diehl, Jie Zheng, Yu Lin, Bjoern Peters A 'cell line cell' is a part of a cell line established through the passaging/selection of a primary cultured cells or the experimental modification of an existing cell line. New types of cell line cells are established after sufficient passaging of a primary culture to establish a stable and homogenous population that qualifies as a line (typically 1-20 passages), or following some spontaneous or experimental modification that confers novel characteristics to an existing line. A cell line cell typically has mutations of five or more genes compared to the original cell that derives the cell line cell. Some gene mutations may turn on some oncogenes. Cell line cells can be in active culture, stored in a quiescent state for future use (e.g. frozen in liquid nitrogen), or applied in experimental procedures. cell line cell immortal cell line cell A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line. Yongqun He, Matthew Brush, Allen Xiang, Asiyah Yu Lin, Sirarat Sarntivijai, James Malone, Jie Zheng, Tomasz Adamusiak continuous cell line cell permanent cell line cell immortal cell line cell cell line He, Tong-Chuan, et al., Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512.: "To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene". Note that common usage in the literature is often of the form "a human colorectal cancer cell line", as seen above. But such references to studies in "a line" refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'. A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture). A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture). In the spring of 2013, a working group comprised of domain experts and representatives from CLO, OBI, CL, and ReO worked to establish a consensus model and definitions of cultured cells across these efforts. This included a careful characterization of how the term 'cell line' should be defined and applied. Notes about this work and its outcomes can be found on the CLO wiki here: http://code.google.com/p/clo-ontology/wiki/Cell_Lines MB, SS, JZ, MAH, BP, CS, YH The term 'line' is used when a culture has undergone an intentional experimental process to establish a more uniform and stable population of cells (see 'establishing cell line'). This will require one or more passages, but may involve additional selection processes. Through such passaging and/or selection processes, the resulting 'line' attains some level of genetic stability and compositional homogeneity which is typically absent in primary cultures. Because of their relative homogeneity, ‘lines’ are capable of being characterized and stably propagated over a period of time. A new *type* of cell line can be established not only through the passaging/selection of a primary culture, but also through experimental modifications of existing lines (e.g. immortalization, stable genetic modifications, drug selection for a resistant subset, etc.). The definition provided here establishes the 'scale' of cell populations that qualify as cell lines - specifically those with a shared propagation history in culture. In this way, the 'cell line' class demarcates populations that represent what researchers actually use in the practice of science - e.g. as inputs to culturing, experimentation, and sharing. The definition is such that cell lines will exhibit important attributes. For example, they will have a relatively homogenous cell type composition as they have experienced similar selective pressures due to their continuous co-propagation. In addition, these populations can also be characterized by a passage number, again owing to their common passaging history.  As defined here, 'cell line' can refer to a population of cells in active culture, applied experimentally, or stored in a quiescent state for future use. cell line LCL-1042 697 697 cell CHEMBL: CHEMBL3308147 CVCL: CVCL_0079 HyperCLDB: cl117 Sanger: COSMIC ID:906800 293 293 HEK HEK 293 HEK-293 Human Embryonic Kidney 293 293 cell WEB: http://hek293.com/ WEB: http://web.expasy.org/cellosaurus/CVCL_0045 WEB: https://www.atcc.org/Products/All/CRL-1573.aspx HEK293 ATCC: CRL-1573 BTO: BTO_0000007 EFO: EFO_0001182) RRID: CVCL_0045 293T/17 WEB: https://www.atcc.org/Products/All/CRL-11268.aspx 293T/17 cell ATCC: CRL-11268 LCL-1601 A549 A549 cell ATCC: CCL-185 CHEMBL: CHEMBL3307651 CVCL: CVCL_0023 EFO: EFO_0001086 HyperCLDB: cl207 LCL-1756 ACHN ACHN cell ATCC: CRL-1611 CHEMBL: CHEMBL3307633 CVCL: CVCL_1067 EFO: EFO_0002108 AML12 AML12 cell ATCC: CRL-2254 BA/F3 BA/F3 cell HyperCLDB: cl5028 LCL-1310 BT-549 disease: ductal carcinoma BT-549 cell ATCC: HTB-122 CHEMBL: CHEMBL3308490 CVCL: CVCL_1092 EFO: EFO_0001096 LCL-1300 C-33 A C-33 A cell ATCC: HTB-31 LCL-1170 Caco-2 disease: colorectal adenocarcinoma Caco-2 cell ATCC: HTB-37 CHEMBL: CHEMBL3307519 CVCL: CVCL_0025 EFO: EFO_0001099 HyperCLDB: cl618 MeSH: D018938 CAKI-1 CAKI-1 cell HyperCLDB: cl623 LCL-1774 Caki-1 disease: clear cell carcinoma (kidney primary) Caki-1 cell ATCC: HTB-46 CHEMBL: CHEMBL3307522 CVCL: CVCL_0234 EFO: EFO_0002149 LCL-1580 ZN Calu-1 disease: epidermoid carcinoma (lung primary) Calu-1 cell ATCC: HTB-54 CHEMBL: CHEMBL3308031 CVCL: CVCL_0608 EFO: EFO_0002151 HyperCLDB: cl631 HyperCLDB: cl632 LCL-1012 CCRF-CEM CCRF-CEM cell ATCC: CCL-119 CHEMBL: CHEMBL3307641 CVCL: CVCL_0207 EFO: EFO_0002128 CHL-1 CHL-1 cell ATCC: CRL-9446 CHO Chinese Hamster Ovary cell CHO cell HyperCLDB: cl721 MeSH: D016466 CHO-K1 CHO-K1 cell ATCC: CCL-61 LCL-1173 COLO 205 disease: colorectal adenocarcinoma (colon primary) COLO 205 cell ATCC: CCL-222 CHEMBL: CHEMBL3308348 CVCL: CVCL_0218 ECACC: 87061208 EFO: EFO_0003082 COS-7 COS-7 cell ATCC: CRL-1651 MeSH: D019556 LCL-1175 DLD-1 disease: colorectal adenocarcinoma DLD-1 cell ATCC: CCL-221 CHEMBL: CHEMBL3307580 CVCL: CVCL_0248 LCL-1146 DU 145 disease: carcinoma (prostate primary) DU 145 cell ATCC: HTB-81 H-4-II-E disease: hepatoma H-4-II-E cell ATCC: CRL-1548 H69AR disease: carcinoma; small cell lung cancer; multidrug resistant H69AR cell ATCC: CRL-11351 LCL-1161 immortal human epithelial cell line cell that was derived from some colon epithelial cell from a human patient with the disease colon carcinoma HCT 116 HCT-116 HCT116 WEB: http://web.expasy.org/cellosaurus/CVCL_0291 WEB: https://www.atcc.org/products/all/CCL-247.aspx disease: colorectal carcinoma HCT 116 cell ATCC: CCL-247 ECACC: 91091005 HyperCLDB: cl1575 MeSH: D045325 RRID:CVCL_0291 LCL-1053 HEL HEL cell CHEMBL: CHEMBL3308090 CVCL: CVCL_0001 DSMZ: ACC 11 HyperCLDB: cl1585 LCL-1512 an immortal human uterine cervix-derived epithelial cell line that was derived from cervical adenocarcinoma cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of her cancer on October 4, 1951. HeLa WEB: http://en.wikipedia.org/wiki/HeLa WEB: http://www.atcc.org/products/all/CCL-2.aspx WEB: https://www.ncbi.nlm.nih.gov/pubmed/12001993 HeLa cell ATCC: CCL-2 CHEMBL: CHEMBL3308376 EFO: EFO_0001185 HyperCLDB: cl1601 MeSH: D006367 RRID:CVCL_0030 LCL-1925 HEP G2 HEP-G2 HEPG2 Hep G2 HepG2 WEB: http://web.expasy.org/cellosaurus/CVCL_0027 WEB: https://en.wikipedia.org/wiki/Hep_G2 WEB: https://www.atcc.org/products/all/HB-8065.aspx Hep G2 cell ATCC: HB-8065 HyperCLDB: cl1644 RRID:CVCL_0027 LCL-1054 HL-60 disease: promyeloblast; acute promyelocytic leukemia HL-60 cell ATCC: CCL-240 CHEMBL: CHEMBL3307654 CVCL: CVCL_0002 EFO: EFO_0002793 HyperCLDB: cl1684 HyperCLDB: cl1689 MeSH: D018922 LCL-1315 HS578T Hs 578T disease: ductal carcinoma Hs 578T cell ATCC: HTB-126 HT-1080 disease: fibrosarcoma HT-1080 cell ATCC: CCL-121 LCL-1180 HT-29 HT29 disease: colorectal adenocarcinoma HT-29 cell ATCC: HTB-38 CHEMBL: CHEMBL3307768 CVCL: CVCL_0320 EFO: EFO_0001193 HyperCLDB: cl1752 MeSH: D019073 HUV-EC-C HUVEC WEB: https://www.atcc.org/Products/All/CRL-1730.aspx HUV-EC-C cell ATCC: CRL-1730 IEC-6 disease: epithelium IEC-6 cell ATCC: CRL-1592 HyperCLDB: cl1802 an immortalized human T lymphocyte cell that was derived in the late 1970s from the peripheral blood of a 14-year-old boy with T cell leukemia JURKAT WEB: https://en.wikipedia.org/wiki/Jurkat_cells disease: leukemia, T cell JURKAT cell HyperCLDB: cl5296 MeSH: D019169 RRID: CVCL_0065 L6 L6 cell ATCC: CRL-1458 LCL-1460 an immortal breast cancer cell line cell isolated in 1970 from a 69-year-old Caucasian woman. ZN MCF 7 cell MCF-7 cell MCF7 WEB: http://web.expasy.org/cellosaurus/CVCL_0031 WEB: https://en.wikipedia.org/wiki/MCF-7 disease: adenocarcinoma (mammary gland primary) MCF7 cell ATCC: HTB-22 CHEMBL: CHEMBL3308403 EFO: EFO_0002082 HyperCLDB: cl3366 HyperCLDB: cl3372 RRID: CVCL_0031 LCL-1461 an immortal breast cancer cell line cell derived from a human patient with breast adenocarcinoma ZN, YH MDA-MB-231 MDA-MB-231 cell ATCC: HTB-26 CHEMBL: CHEMBL3307960 EFO: EFO_0001209 RRID: CVCL_0062 MDCK MDCK cell HyperCLDB: cl5078 LCL-1305 ME-180 disease: epidermoid carcinoma (cervix primary) ME-180 cell ATCC: HTB-33 CHEMBL: CHEMBL3308114 CVCL: CVCL_1401 MRC-5 MRC-5 cell ATCC: CCL-171 HyperCLDB: cl3564 Mv 1 Lu Mv 1 Lu cell HyperCLDB: cl3604 HyperCLDB: cl3608 HyperCLDB: cl3609 NIH-3T3 NIH-3T3 cell ATCC: CRL-1658 HyperCLDB: cl3710 HyperCLDB: cl3711 MeSH: D041681 LCL-2000 SH-SY5Y SHSY5Y https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Bone_Marrow/CRL-2266.aspx SH-SY5Y cell ATCC: CRL-2266 LCL-1282 A melanoma cell line cell. This cell line was established in 1974 from a metastatic site (axillary lymph node) in a 24-year-old Caucasian female with malignant melanoma, expresses mutant B-Raf (V600E) and wildtype N-Ras. SK-MEL-5 WEB: http://web.expasy.org/cellosaurus/CVCL_1706 WEB: http://www.ncbi.nlm.nih.gov/pubmed/3121170 WEB: https://strap.nci.nih.gov/celline_detail.php?sample_id=56 SK-MEL-5 cell ATCC: HTB-70 CHEMBL: CHEMBL3307744 CVCL: CVCL_0527 EFO: EFO_0002080 PubChem AID: 488899 Sanger: COSMIC ID:905956 LCL-1971 SK-N-SH SK-N-SH cell ATCC: HTB-11 CHEMBL: CHEMBL3307745 CVCL: CVCL_0531 EFO: EFO_0003072 LCL-1195 SW403 SW403 cell ATCC: CCL-230 PubChem AID: 504653 RRID: CVCL_0545 Sanger: COSMIC ID:910908 LCL-1072 THP-1 THP1 THP-1 cell ATCC: TIB-202 CHEMBL: CHEMBL3307574 CVCL: CVCL_0006 EFO: EFO_0001253 HyperCLDB: cl4514 LCL-1431 U-2 OS U2OS WEB: https://www.atcc.org/Products/All/HTB-96.aspx U-2 OS cell ATCC: HTB-96 CHEMBL: CHEMBL3307757 CVCL: CVCL_0042 EFO: EFO_0002869 U87 MG There is a CLO term for the cell line already: http://purl.obolibrary.org/obo/CLO_0009464 obsolete: U87 MG cell HyperCLDB: cl5280 Vero Vero cell ATCC: CCL-81 HyperCLDB: cl4644 MeSH: D014709 VERO 76 VERO 76 cell ATCC: CRL-1587 HyperCLDB: cl4655 VERO C1008 VERO C1008 cell ATCC: CRL-1586 HyperCLDB: cl4656 HyperCLDB: cl4657 LCL-1346 A human glioblastoma cell line cell. The cell line is part of the NCI-60 screening panel. Oliver He, Jiangan Xie SNB-75 SNB75 WEB: http://web.expasy.org/cellosaurus/CVCL_1706 WEB: http://www.ncbi.nlm.nih.gov/pubmed/3121170 WEB: https://strap.nci.nih.gov/celline_detail.php?sample_id=56 SNB75 cell PubChem AID: 652144 Sanger: COSMIC ID:905982 LCL-1134 Oliver He, Jiangan Xie SU-DHL-10 SU-DHL-10 cell DSMZ: ACC 576 LCL-1138 Oliver He, Jiangan Xie SU-DHL-6 SU-DHL-6 cell DSMZ: ACC 572 BJeLR cell is BJ fibroblast cell line cell transformed with hTERT, genomic SV40 LT and ST oncoproteins, and oncogenic HRASV12. YH, JX BJeLR PubChem probe report: http://www.ncbi.nlm.nih.gov/books/NBK98919/ PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18355723 BJeLR cell PubChem AID: 2635 BJeH=BJ derivative transformed only with hTERT (BJ fibroblasts were derived from primary human cells by transformation with hTERT, genomic SV40 Large T (LT) and Ssmall T (ST)) YH, JX BJeLR PubChem probe report: http://www.ncbi.nlm.nih.gov/books/NBK98919/ PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18355723 BJeH cell PUbChem AID: 493051 A human follicular lymphoms cell line Oliver He, Jiangan Xie RS11846 WEB: http://cellfinder.org/ontology?id=CELDA_00012667 RS-11846 cell PubChem AID: 743410 RRID: CVCL_E048 A derivative of the CHO cell line that is adapted to high-density, serum-free suspension culture YH, JX WEB: https://www.thermofisher.com/order/catalog/product/R80007 CHO-S cell PubChem AID: 624379 DRD=BJ fibroblasts expressing hTERT, SV40 small T oncoprotein, dominant negative p53, cyclin D1, a mutant form of CDK4, along with the oncogene HRASV12 JX, YH WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683762/ DRD cell PubChem AID: 2633 HL2/3 is a derivative of HeLa cells and contains a stably integrated copies of the HIV-1 molecular clone HXB2/3gpt. JX, YH WEB: https://www.aidsreagent.org/reagentdetail.cfm?t=cell_lines&id=83 WEB: https://www.ncbi.nlm.nih.gov/pubmed/?term=2078409 HL2/3 PubChem AID: 504574 HeLa-MAGI-CCR5 cells are derived from HeLa cells and express human CD4, CXCR4 and CCR5, and an integrated gene encoding the b-galactosidase gene expressed from the HIV long terminal repeat. JX, YH WEB: http://web.expasy.org/cellosaurus/CVCL_D260 MAGI-CCR5 cells; HeLa-R5-16, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL4 3 HeLa-MAGI-CCR5 PubChem AID: 504341 RRID: CVCL_D260 HeLa-R5-16 (gift from Roche Palo Alto, LLC) is a derivative of HeLa cells, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL43 JX, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/?term=16314403 HeLa-R5-16 PubChem AID: 504341 RD-HGA16 is derivative of CHO cells stably transfected with the promiscuous G-protein Gα16 gene and hygromycin-resistant. RD-HGA16 is from FLIPR LiveWare Cells (Molecular Devices, Sunnyvale CA), a series of cells and expression vectors successfully used in drug discovery, based on G-protein chimeras developed by Bruce Conklin and colleagues at the Gladstone Institute, UCSF. YH, JX WEB: http://go.pardot.com/l/83942/2015-06-17/njr/83942/4464/Data_Sheet__FLIPR_LiveWare_G_protein_Cells_and_Plasmids.pdf RD-HGA16 PubChem AID: 624467 Sufu-KO-LIGHT cells were derived from Sufu knockout mouse embryonic fibroblasts according to the method of Chen et al. [Genes Dev. 2009;23(16): 1910-28.] The cells were co-transfected with the zeocin resistance vector (pVgRXR, Invitrogen) and a firefly luciferase reporter driven by eight Gli binding sites and a γ-crystallin basal promoter (8XGHBS-FL). Sufu-KO-LIGHT lacks Sufu and exhibits constitutive Hh target gene expression in response to endogenous Gli activators. JX, YH WEB: https://www.google.com/patents/WO2013192301A1?cl=en Sufu-KO-LIGHT cell PubChem AID: 588413 A Hela-derived cell line cell that expresses ubiquitinated GFP (Green Fluroescent Protein) JX, YH Ub-G76V-GFP/HeLa PubChem AID: 463185 602478 The GripTite™ 293 MSR Cell Line is a genetically engineered Human Embryonic Kidney (HEK 293) cell line that expresses the human macrophage scavenger receptor and strongly adheres to standard tissue culture plates for dependable results. BAO, YH GripTite™ 293 MSR https://pubchem.ncbi.nlm.nih.gov/bioassay/602478 https://www.thermofisher.com/order/catalog/product/R79507 GripTite 293 MSR cell BAO: BAO_0030043 ThermoFisher: R79507 493062 A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein BCL-2. BAO, YH http://www.ncbi.nlm.nih.gov/pubmed/16697956 https://www.google.com/patents/WO2007123791A2?cl=en https://www.ncbi.nlm.nih.gov/books/NBK143557 2B4/BCL-2 cell BAO: BAO_0030042 493059 A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein MCL-1. BAO, YH http://www.ncbi.nlm.nih.gov/pubmed/16697956 https://www.google.com/patents/WO2007123791A2?cl=en https://www.ncbi.nlm.nih.gov/books/NBK143557 2B4/MCL-1 cell BAO: BAO_0030044 463235 AVA5 cells are derived from the Huh-7 human hepatoma cell line, stably-expressing the HCV replicon (sub-genomic [CON1], genotype 1b); http://www.apath.com/index.html. See also PMID: 27013634, 1110665, 10390360 BAO, YH https://www.ncbi.nlm.nih.gov/pubmed/10390360 https://www.ncbi.nlm.nih.gov/pubmed/1110665 https://www.ncbi.nlm.nih.gov/pubmed/27013634 AVA5 cell BAO: BAO_0030045 624396 A murine leukemia cell line driven by the overexpression of Myc and BCL-2. BAO, YH http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919900/ BCL-2 1863 cell BAO: BAO_0030052 1353 An immortalised mouse neural progenitor cell line cell that is capable of differentiation in vitro and is established by retorviral-mediated transduction of the avian myc oncogene into mitotic progenitor cells of neonatal mouse cerrebellum. Mouse strain CD1 x C57BL/6. BAO, YH http://web.expasy.org/cellosaurus/CVCL_4511 http://www.sigmaaldrich.com/catalog/product/sigma/07062902 C17.2 cell BAO: BAO_0030046 651610 CEM21 (aka CEM#21 or CEM-R5Luc1#21) is derived from CEM.NKR-CCR5 by stable transfecttion of a Tet-activator responsive Luciferase reporter Oliver He CEM#21 CEM-R5Luc1#21 https://www.ncbi.nlm.nih.gov/pubmed/10516002 CEM21 cell BAO: BAO_0030049 434939 DPX2 (aka DPX-2) is a HepG2-derived cell line stably integrated with a PXR (pregnane X receptor) expression vector plus a luciferase reporter, used to detect PXR activation/ CYP3A induction BAO, YH DPX-2 http://www.ncbi.nlm.nih.gov/pubmed/15548381 http://www.ncbi.nlm.nih.gov/pubmed/22912432 DPX2 cell BAO: BAO_0030035 623928 FA2N-4 is a human hepatocyte cell line. Reference: http://web.expasy.org/cellosaurus/CVCL_0267 BAO, YH http://cellfinder.org/ontology?id=CF_194407 http://purl.bioontology.org/ontology/MCCL/MCC_0000158 http://web.expasy.org/cellosaurus/CVCL_0267 FA2N-4 cell BAO: BAO_0030036 651646 HBL-1 (aka human is an EBV-negative B-cell lymphoma cell line established from the pleural effusion of a patient with malignant lymphoma, diffuse, large cell. BAO, YH http://purl.obolibrary.org/obo/BTO_0002522 http://web.expasy.org/cellosaurus/CVCL_4213 HBL-1 cell BAO: BAO_0030037 BTO: BTO_0002522 RRID:CVCL_4213 449755 HMC-1-8 is a human breast cancer cell line BAO, YH http://portals.broadinstitute.org/ccle/cell%20lines/HMC18_BREAST http://web.expasy.org/cellosaurus/CVCL_2949 HMC-1-8 cell BAO: BAO_0030037 RRID:CVCL_2949 2717 HMLE_sh_ECAD is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down E-Cadherin (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT) BAO, YH http://www.ncbi.nlm.nih.gov/pubmed/19682730 http://www.ncbi.nlm.nih.gov/pubmed/22941295 HMLE_sh_ECAD cell BAO: BAO_0030038 463074 HMLE_sh_eGFP is a human breast epithelial cell line containing shRNA to GFP (green fluorescent reporter); used as an isogenic control line for HMLE_sh_ECAD BAO, YH http://www.ncbi.nlm.nih.gov/pubmed/19682730 http://www.ncbi.nlm.nih.gov/pubmed/22941295 HMLE_sh_eGFP cell BAO: BAO_0030039 588703 HMLE_sh_TWIST is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down TWIST (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT); isogenic with another CSC line, HMLE_sh_ECAD BAO, YH http://www.ncbi.nlm.nih.gov/pubmed/19682730 http://www.ncbi.nlm.nih.gov/pubmed/22941295 HMLE_sh_TWIST cell BAO: BAO_0030040 651570 An engineered 3T3 mouse fibroblast cell line, which expresses the firefly luciferase reporter gene under the control of Wnt-responsive promoters (TCF/LEF). http://www.enzolifesciences.com/ENZ-61001/leading-light-wnt-reporter-assay-starter-kit/ LEADING LIGHT Wnt Reporter cell line cell BAO: BAO_0030031 624396 MCL-1 1780 is a murine leukemia cell line driven by the overexpression of Myc and MCL-1. BAO, YH http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919900/ Source: Anthony Letai (Dana Farber) MCL-1 1780 cell BAO: BAO_0030053 652260 MG213 is a subline of the BRG1/BRM-deficient cell line SW13 (http://purl.obolibrary.org/obo/CLO_0009185) that contains a stably integrated glucocorticoid-responsive MMTV-luciferase reporter. BAO, YH http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615482/ MG213 cell BAO: BAO_0030048 624495 A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (DRD2L, long form of human DRD2) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD2L-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. BAO, YH https://www.discoverx.com/products/cell-line/cho-k1-drd2l-beta-arrestin-cell-line-93-0579c2 PathHunter CHO-K1 DRD2L Beta-Arrestin cell BAO: BAO_0030056 624500 A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (human DRD3) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD3-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. BAO, YH https://www.discoverx.com/products/cell-line/cho-k1-drd3-beta-arrestin-cell-line-93-0591c2 PathHunter CHO-K1 DRD3 Beta-Arrestin cell BAO: BAO_0030057 652166 RAW-Blue cells are derived from the murine RAW 264.7 macrophages with chromosomal integration of a secreted embryonic alkaline phosphatase (SEAP) reporter construct inducible by NF-κB and AP-1. BAO, YH http://web.expasy.org/cellosaurus/CVCL_X594 http://www.invivogen.com/raw-blue RAW-Blue cell BAO: BAO_0030060 RRID:CVCL_X594 624032 A rat immortilized Schwann cell line. S-16 cell http://purl.obolibrary.org/obo/BTO_0002937 http://web.expasy.org/cellosaurus/CVCL_B072 S16 cell BAO: BAO_0030061 BTO: BTO_0002937 RRID:CVCL_B072 1355 A mouse melanoma cell line (which harbors N-Ras mutation), isolated from a small amelanotic lung metastasis in a mouse with a s.c. K-1735 tumor. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158838/ http://www.ncbi.nlm.nih.gov/pubmed/2832058/ SW1 cell BAO: BAO_0030062 485366 'Tango cell' refers to one of many stable cell lines, all based on the parental line HEK293T, designed to work in a 'Tango beta-arrestin' recruitiment assay to measure receptor activation for more than 300 GPCRs. See PMID25895059 and https://pdspdb.unc.edu/prestotango/ BAO, YH http://www.ncbi.nlm.nih.gov/pubmed/25895059 https://pdspdb.unc.edu/prestotango/ https://www.ncbi.nlm.nih.gov/pubmed/18165312 Tango cell BTO: BAO_0030063 651712 Human diffuse large B cell lymphoma cell line derived from a 62-year-old male patient BAO, YH http://web.expasy.org/cellosaurus/CVCL_A442 TMD8 cell BAO: BAO_0030064 RRID:CVCL_A442 504935 U87-EGFRvIII (aka U87/vIII) is a stable cell line derived from U87MG (a human glioblastoma) to overexpress the most common mutation of epidermal growth factor receptor (EGFR) found in human glioblastomas--an in-frame deletion of an 801-bp sequence in the extracellular domain of EGFR termed EGFRvIII. (descr. in PMID 15548697). BAO, YH U87/vIII http://www.ncbi.nlm.nih.gov/pubmed/15548697/ U87-EGFRvIII cell BAO: BAO_0030059 A disease that involving errors in metabolic processes of building or degradation of molecules. ICD10CM:E88.9 ICD9CM:277.9 MESH:D008659 NCI:C3235 SNOMEDCT_US_2020_03_01:75934005 UMLS_CUI:C0025517 metabolic disease disease_ontology DOID:0014667 disease of metabolism A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash. GARD:6038 Chikungunya fever disease_ontology DOID:0050012 chikungunya An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism. disease_ontology DOID:0050013 carbohydrate metabolism disease An ehrlichiosis that results in infection located in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted by lone start tick (Amblyomma americanum ). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash. DOID:0050021 DOID:0050022 human granulocytic ehrlichiosis disease_ontology HGE DOID:0050025 human granulocytic anaplasmosis An ehrlichiosis that results in infection located in monocyte or located in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted by black-legged tick (Ixodes scapularis), transmitted by western black-legged tick (Ixodes pacificus) or transmitted by castor bean tick (Ixodes ricinus). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash. DOID:14091 GARD:72 disease_ontology Ehrlichiosis chafeensis DOID:0050026 human monocytic ehrlichiosis An acquired metabolic disease that is characterized by abnormal mineral metabolism. disease_ontology DOID:0050032 mineral metabolism disease A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash. DOID:0050034 DOID:0050036 Rickettsia africae spotted fever south african tick-bite fever disease_ontology DOID:0050035 African tick-bite fever A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy. Rickettsia heilongjiangensis spotted fever disease_ontology DOID:0050046 Far Eastern spotted fever A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities. DOID:0050049 Rickettsia japonica spotted fever oriental spotted fever disease_ontology DOID:0050050 Japanese spotted fever A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin. MESH:D004887 disease_ontology DOID:0050061 erysipeloid A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens. disease_ontology DOID:0050072 adiaspiromycosis An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage. disease_ontology DOID:0050073 invasive aspergillosis A nutritional deficiency that is disease characterized by a cardiomyopathy secondary to selenium deficiency. GARD:8761 disease_ontology DOID:0050083 Keshan disease A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. infectious disease DOID:10115 DOID:11078 DOID:1304 DOID:1321 DOID:2040 DOID:2288 DOID:3099 DOID:4120 DOID:4620 DOID:5256 DOID:945 DOID:95 DOID:9532 DOID:9696 ICD9CM:079.0 UMLS_CUI:C0001485 infectious disease disease_ontology DOID:0050117 DO:wk disease by infectious agent A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis. DOID:10840 ICD10CM:A83.5 ICD9CM:062.5 MESH:D004670 SNOMEDCT_US_2020_03_01:69627004 UMLS_CUI:C0014053 California Encephalitis California virus encephalitis Neuroinvasive California encephalitis virus infection disease_ontology DOID:0050118 La Crosse encephalitis A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages. DOID:6453 GARD:6589 ICD10CM:D76.1 MESH:D051359 NCI:C34792 OMIM:PS267700 ORDO:540 SNOMEDCT_US_2020_03_01:190958003 UMLS_CUI:C0024291 haemophagocytic syndrome disease_ontology DOID:0050120 Xref MGI. MESH:C537250 added from NeuroDevNet [WAK]. hemophagocytic lymphohistiocytosis A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip. DOID:2052 DOID:9564 ICD10CM:J01 ICD9CM:461 NCI:C128411 SNOMEDCT_US_2020_03_01:195649005 UMLS_CUI:C0149512 disease_ontology DOID:0050127 sinusitis Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions. disease_ontology DOID:0050129 secretory diarrhea A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host. DOID:13370 ICD10CM:B36.9 MESH:D010854 SNOMEDCT_US_2020_03_01:266218008 SNOMEDCT_US_2020_03_01:47382004 UMLS_CUI:C0031898 UMLS_CUI:C2980104 Steroid-modified tinea infection piedra disease_ontology DOID:0050133 Adding a UMLS CUI for piedra C2980104. superficial mycosis A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions. disease_ontology DOID:0050134 cutaneous mycosis A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma. disease_ontology DOID:0050135 subcutaneous mycosis A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs. disease_ontology DOID:0050136 systemic mycosis A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. disease_ontology DOID:0050140 acute diarrhea A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins. disease_ontology DOID:0050141 intestinal botulism An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing. DOID:13750 ICD10CM:J35.02 ICD9CM:474.01 SNOMEDCT_US_2020_03_01:195794009 UMLS_CUI:C0396023 chronic adenoiditis disease_ontology DOID:0050145 adenoiditis An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans. MESH:D059249 Singapore ear disease_ontology DOID:0050147 otomycosis An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe. DOID:11795 DOID:9390 ICD10CM:J04 ICD10CM:J37.1 ICD9CM:464 ICD9CM:476.1 SNOMEDCT_US_2020_03_01:276443001 SNOMEDCT_US_2020_03_01:83271005 UMLS_CUI:C0155811 UMLS_CUI:C0155837 disease_ontology DOID:0050148 laryngotracheitis A legionellosis that involves a milder respiratory illness without pneumonia. Symptoms include fever, headache and muscle aches which last for 2 to 5 days. disease_ontology DOID:0050150 Pontiac fever A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough. ICD10CM:J69.0 MESH:D011015 SNOMEDCT_US_2020_03_01:47839005 UMLS_CUI:C0032290 disease_ontology DOID:0050152 aspiration pneumonia An aspergillosis that presents as a clump of tangled mass of Aspergillus fungus fibres, blood clots, and white blood cells, which exists in the cavities of the lungs that develop in an area of previous lung disease or lung scarring. disease_ontology DOID:0050153 pulmonary aspergilloma A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell). disease_ontology DOID:0050155 sensory system disease A pulmonary fibrosis that is characterized by scarring of the lung. EFO:0000768 GARD:8609 ICD10CM:J84.112 ICD9CM:516.31 MESH:D054990 NCI:C35716 OMIM:178500 SNOMEDCT_US_2020_03_01:28168000 UMLS_CUI:C1800706 FIBROCYSTIC PULMONARY DYSPLASIA IDIOPATHIC PULMONARY FIBROSIS, FAMILIAL cryptogenic fibrosing alveolitis disease_ontology DOID:0050156 OMIM mapping confirmed by DO. [SN]. idiopathic pulmonary fibrosis An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope. DOID:2798 GARD:1620 ICD10CM:J84.116 ICD9CM:516.36 MESH:D018549 NCI:C62586 SNOMEDCT_US_2020_03_01:129458007 UMLS_CUI:C0242770 BOOP Cryptogenic organising pneumonitis Cryptogenic organizing pneumonitis bronchiolitis obliterans organising pneumonia bronchiolitis obliterans organizing pneumonia cryptogenic organising pneumonia idiopathic bronchiolitis obliterans with organising pneumonia idiopathic bronchiolitis obliterans with organizing pneumonia disease_ontology DOID:0050157 cryptogenic organizing pneumonia An anthrax disease that results in infection located in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches. pulmonary anthrax respiratory anthrax wool-sorters' disease woolsorters' disease disease_ontology DOID:0050160 inhalation anthrax A respiratory system disease which involves the lower respiratory tract. ICD9CM:478.19 SNOMEDCT_US_2020_03_01:195823002 UMLS_CUI:C0029581 disease_ontology DOID:0050161 lower respiratory tract disease An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. GARD:8466 OMIM:240300 Autoimmune Polyglandular Syndrome I Whitaker syndrome autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy disease_ontology DOID:0050167 autoimmune polyendocrine syndrome type 1 An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene. GARD:7611 OMIM:269200 Schmidt syndrome disease_ontology DOID:0050168 autoimmune polyendocrine syndrome type 2 A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight. GARD:6225 disease_ontology DOID:0050169 cutaneous lupus erythematosus A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis. DOID:0050176 DOID:10251 DOID:10252 GARD:5216 ICD10CM:A84.1 ICD9CM:063.2 MESH:D004675 SNOMEDCT_US_2020_03_01:16901001 UMLS_CUI:C0014054 Central European encephalitis Far Eastern TBE Russian spring-summer encephalitis Siberian tick-borne encephalitis Taiga encephalitis Western European tick-borne encephalitis west-Siberian encephalitis disease_ontology DOID:0050175 tick-borne encephalitis A genetic disease that is the result of one or more abnormal alleles and may be dominant, semi-dominant, or recessive. disease_ontology DOID:0050177 monogenic disease A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness. GARD:6372 MESH:D004892 disease_ontology DOID:0050185 erythema multiforme A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations. disease_ontology DOID:0050194 Argentine hemorrhagic fever A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia. disease_ontology DOID:0050196 Venezuelan hemorrhagic fever A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload. disease_ontology DOID:0050200 Korean hemorrhagic fever A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal. ICD10CM:G70.80 ICD9CM:358.3 MESH:D015624 NCI:C3155 SNOMEDCT_US_2020_03_01:230688006 UMLS_CUI:C0022972 Eaton-Lambert syndrome LEMS Lambert-Eaton syndrome disease_ontology DOID:0050214 Lambert-Eaton myasthenic syndrome A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma. GARD:9554 Naegleria fowleri infection disease_ontology DOID:0050242 primary amebic meningoencephalitis A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death. GARD:12651 Acanthamoeba encephalitis Acanthamoeba granulomatous encephalitis Granulomatous Amebic Encephalitis due to Acanthamoeba granulomatous amoebic encephalitis disease_ontology DOID:0050246 granulomatous amebic encephalitis A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis. GARD:683 disease_ontology DOID:0050256 angiostrongyliasis A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo. GARD:393 MESH:D058285 disease_ontology DOID:0050266 tungiasis A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain. disease_ontology DOID:0050268 ophthalmomyiasis An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions. disease_ontology DOID:0050279 conidiobolomycosis An opportunistic mycosis that involves localized or hematogenously disseminated fungal infection by Fusarium solani or Fusarium oxysporum. Skin lesions are seen in neutropenic patients, and indolent cellulitis or soft-tissue necrosis occur in immunocompromised patients at the site of trauma. MESH:D060585 disease_ontology DOID:0050289 fusariosis An opportunistic mycosis that results_in disseminated infection, has_material_basis_in Trichosporon and results_in_formation_of nontender erythematous nodules anywhere on the body. MESH:D060586 disease_ontology DOID:0050290 trichosporonosis A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract. disease_ontology DOID:0050292 primary systemic mycosis A refractive error that is characterized by the significant difference in perceived sizes of an object between the two eyes. MESH:D000839 disease_ontology DOID:0050304 aniseikonia A hypothyroidism that is present at birth. DOID:11631 DOID:11632 GARD:1487 ICD10CM:E00.1 ICD10CM:E03.1 ICD9CM:243 MESH:D003409 NCI:C26734 NCI:C98921 OMIM:PS275200 SNOMEDCT_US_2020_03_01:217710005 SNOMEDCT_US_2020_03_01:75065003 UMLS_CUI:C0010308 UMLS_CUI:C0342200 disease_ontology DOID:0050328 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital hypothyroidism A syndrome that is characterized by autosomal dominant inheritance of abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes. OMIM:149730 LEVY-HOLLISTER SYNDROME lacrimoauriculodentodigital syndrome disease_ontology DOID:0050331 OMIM mapping confirmed by DO. [SN]. LADD syndrome A vestibular disease that is characterized by progressive hearing loss resulting from congenital enlargement of the vestibular aqueducts. GARD:8651 disease_ontology DOID:0050332 OMIM mapping confirmed by DO. [SN]. enlarged vestibular aqueduct A phosphorus metabolism disease that is characterized by hypophosphatemia and the symptoms of osteomalacia including bone pain, skeletal deformities and osteoarthritis. MESH:D017674 disease_ontology DOID:0050336 hypophosphatemia A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread. disease_ontology DOID:0050338 primary bacterial infectious disease A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder. disease_ontology DOID:0050339 commensal bacterial infectious disease A bacterial infectious disease that results_in infection by bacteria in individuals whose host defense mechanisms have been compromised. disease_ontology DOID:0050340 opportunistic bacterial infectious disease A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has symptom blurred vision, has symptom diplopia, has symptom dysarthria, has symptom dysphonia, has symptom dysphagia and has symptom descending muscle paralysis. disease_ontology DOID:0050352 foodborne botulism A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins. disease_ontology DOID:0050353 wound botulism A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness. disease_ontology DOID:0050354 infant botulism A bartonellosis that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed. Carrion disease Oroya fever disease_ontology DOID:0050398 Carrion's disease An intestinal disease that has_material_basis_in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer. GARD:6408 MESH:D011125 NCI:C3339 OMIM:PS175100 ORDO:733 SNOMEDCT_US_2020_03_01:72900001 UMLS_CUI:C0032580 adenomatous polyposis of the colon disease_ontology DOID:0050424 OMIM mapping confirmed by DO. [SN]. familial adenomatous polyposis A skin disease that is characterized by ulceration of less than 10 percent of the surface area of the body. The disease is often precipitated by the use of medications, such as antibiotics or antiepileptics, or onset of infection. EFO:0004276 GARD:7700 ICD10CM:L51.1 ICD9CM:695.13 NCI:C79484 NCI:C79777 SNOMEDCT_US_2020_03_01:73442001 UMLS_CUI:C0038325 disease_ontology DOID:0050426 Stevens-Johnson syndrome MESH:D013262 A syndrome that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair. GARD:7910 ICD10CM:Q82.1 MESH:D014983 NCI:C3452 ORDO:910 SNOMEDCT_US_2020_03_01:44600005 UMLS_CUI:C0043346 disease_ontology DOID:0050427 OMIM mapping confirmed by DO. [SN]. xeroderma pigmentosum A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles. MESH:D015776 NCI:C3147 OMIM:600962 OMIM:613000 OMIM:615735 ORDO:2337 SNOMEDCT_US_2020_03_01:81206005 UMLS_CUI:C0022584 UMLS_CUI:C3489771 Thost-Unna Syndrome Unna-Thost Syndrome diffuse nonepidermolytic palmomplantar keratoderma tylosis disease_ontology DOID:0050428 Xref MGI. OMIM mapping confirmed by DO. [SN]. nonepidermolytic palmoplantar keratoderma A pemphigus that is characterized by recurring blistering most commonly occurring in the folds of the skin and has_material_basis_in mutations in the ATP2C1 gene that result in loss of adhesion within the skin. GARD:6559 ICD10CM:Q82.8 MESH:D016506 NCI:C82865 OMIM:169600 SNOMEDCT_US_2020_03_01:79468000 UMLS_CUI:C0085106 BENIGN CHRONIC PEMPHIGUS Pemphigus, Benign Familial disease_ontology DOID:0050429 OMIM mapping confirmed by DO. [SN]. Hailey-Hailey disease A multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis. ICD10CM:E31.22 ICD9CM:258.02 MESH:D018813 NCI:C3226 OMIM:171400 ORDO:247698 SNOMEDCT_US_2020_03_01:721188000 UMLS_CUI:C0025268 MEN2A Sipple syndrome multiple endocrine neoplasia II disease_ontology DOID:0050430 OMIM mapping confirmed by DO. [SN]. multiple endocrine neoplasia type 2A An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle. MESH:D019571 NCI:C84571 OMIM:PS107970 ORDO:217656 ORDO:247 SNOMEDCT_US_2020_03_01:281170005 UMLS_CUI:C0349788 ARVC ARVC cardiomyopathy ARVD arrhythmogenic right ventricular dysplasia arrhythmogenic right ventricular dysplasia/cardiomyopathy disease_ontology DOID:0050431 Xref MGI. OMIM mapping confirmed by DO. [SN]. arrhythmogenic right ventricular cardiomyopathy An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development. GARD:5855 ICD10CM:F84.5 MESH:D020817 NCI:C97159 OMIM:608631 OMIM:608638 OMIM:608781 OMIM:609954 ORDO:1162 SNOMEDCT_US_2020_03_01:154879004 UMLS_CUI:C0236792 disease_ontology DOID:0050432 Xref MGI. OMIM mapping confirmed by DO. [SN]. Asperger syndrome A prion disease that is characterized by insomnia, hallucinations, dementia and death, located_in the brain. GARD:6429 ICD10CM:A81.83 ICD9CM:046.72 MESH:D034062 NCI:C84711 OMIM:600072 SNOMEDCT_US_2020_03_01:83157008 UMLS_CUI:C0206042 disease_ontology DOID:0050433 OMIM mapping confirmed by DO. [SN]. fatal familial insomnia A syndrome that is characterized by global growth retardation of the muscle, liver, brain and eyes as well as constrictive pericarditis and has_material_basis_in mutations in the TRIM37 gene. GARD:95 MESH:D050336 NCI:C84906 OMIM:253250 ORDO:2576 SNOMEDCT_US_2020_03_01:81604003 UMLS_CUI:C0524582 MUL Mulibrey growth disorder Muscle-Liver-Brain-Eye Nanism PERICARDIAL CONSTRICTION AND GROWTH FAILURE Perheentupa Syndrome disease_ontology DOID:0050436 OMIM mapping confirmed by DO. [SN]. mulibrey nanism A lysosomal storage disease that is characterized by cardiomyopathy, skeletal myopathy and intellectual disability and has_material_basis_in mutations in the LAMP2 gene. GARD:9730 MESH:D052120 NCI:C84735 OMIM:300257 SNOMEDCT_US_2020_03_01:419097006 UMLS_CUI:C0878677 ANTOPOL DISEASE PSEUDOGLYCOGENOSIS II disease_ontology DOID:0050437 OMIM mapping confirmed by DO. [SN]. Danon disease A syndrome that is characterized by gonadal dysgenesis, streak gonads, progressive focal segmental glomerulonephropathy and the development of urogenital cancers that is the result of mutation in the WT1 gene. GARD:2375 MESH:D052159 NCI:C122805 OMIM:136680 SNOMEDCT_US_2020_03_01:445431000 UMLS_CUI:C0950122 disease_ontology DOID:0050438 OMIM mapping confirmed by DO. [SN]. Frasier syndrome A syndrome characterized by a combination of hearing loss and visual impairment. GARD:7843 MESH:D052245 NCI:C85217 OMIM:PS276900 ORDO:886 SNOMEDCT_US_2020_03_01:57838006 UMLS_CUI:C0271097 disease_ontology DOID:0050439 Xref MGI. OMIM mapping confirmed by DO. [LS]. Usher syndrome A sphingolipidosis that is characterized by leukodystrophy, ichthyosis, skeletal abnormalities and shortened life expectancy and has_material_basis_in mutation in the SUMF1 gene that results in deficiency in multiple sulfatase enzymes. ICD10CM:E75.26 MESH:D052517 NCI:C84908 OMIM:272200 SNOMEDCT_US_2020_03_01:254076009 SNOMEDCT_US_2020_03_01:54898003 UMLS_CUI:C0268263 UMLS_CUI:C1720864 Sulfatidosis, Juvenile, Austin Type multiple sulfatase deficiency disease disease_ontology DOID:0050441 OMIM mapping confirmed by DO. [SN]. mucosulfatidosis A peroxisomal disease that is characterized by neurological impairment, intellectual disability, hepatosplenomegaly and ichthyosis and results from the accumulation of very long chain fatty acids and phytanic acid, secondary to mutation in the PEX genes. ICD10CM:G60.1 MESH:D052919 NCI:C84789 OMIM:266510 SNOMEDCT_US_2020_03_01:238062008 UMLS_CUI:C0282527 infantile phytanic acid storage disease disease_ontology DOID:0050444 OMIM mapping confirmed by DO. [SN]. infantile Refsum disease A rickets has_material_basis in X-linked mutations in the PHEX gene that lead to increased circulating levels of FGF-23, a phosphate-regulating hormone (phosphatonin), that leads to reduced renal phosphate reabsorption and consequently abnormal bone mineralization. MESH:D053098 NCI:C123265 NCI:C85234 OMIM:307800 UMLS_CUI:C0733682 UMLS_CUI:C1845168 UMLS_CUI:C3540852 Hypophosphatemia, Vitamin D-Resistant Rickets Vitamin D-Resistant Rickets, X-Linked X-linked hypophosphatemia hypophosphatemic rickets X-linked dominant disease_ontology DOID:0050445 OMIM mapping confirmed by DO. [SN]. X-linked dominant hypophosphatemic rickets A skin disease characterized by a defect in the normal process of keratinization of the mucosa. MESH:D053529 NCI:C84760 OMIM:193900 OMIM:615785 ORDO:171723 SNOMEDCT_US_2020_03_01:85388002 UMLS_CUI:C1721005 white sponge nevus white sponge nevus of Cannon disease_ontology DOID:0050448 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary mucosal leukokeratosis A syndrome that is characterized by hypertrophic nails and hyperkeratosis of the hands and feet and has_material_basis in gene mutations that result in changes in keratin. GARD:10753 MESH:D053549 NCI:C84986 OMIM:PS167200 ORDO:2309 SNOMEDCT_US_2020_03_01:39427000 UMLS_CUI:C0265334 UMLS_CUI:C1706595 UMLS_CUI:C1721007 Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome PACHYONYCHIA CONGENITA, JADASSOHN-LEWANDOWSKY TYPE Pachyonychia Congenita Type 1 disease_ontology DOID:0050449 OMIM mapping confirmed by DO. [SN]. pachyonychia congenita A renal tubular transport disease that is has_material_basis_in mutations in genes that produce proteins involved in the kidneys' reabsorption of salt (sodium chloride or NaCl) from urine back into the bloodstream, thus impairing the kidneys' ability to reabsorb salt, leading to the loss of excess salt in the urine (salt wasting). GARD:8547 MESH:D053579 NCI:C84730 OMIM:263800 SNOMEDCT_US_2020_03_01:3188003 UMLS_CUI:C0268450 HYPOMAGNESEMIA-HYPOKALEMIA, PRIMARY RENOTUBULAR, WITH HYPOCALCIURIA disease_ontology DOID:0050450 OMIM mapping confirmed by DO. [SN]. Gitelman syndrome A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. GARD:1030 ICD10CM:I49.8 MESH:D053840 NCI:C142891 OMIM:PS601144 ORDO:130 SNOMEDCT_US_2020_03_01:418818005 UMLS_CUI:C1142166 UMLS_CUI:C1721096 Bangungut Brugada type idiopathic ventricular fibrillation Dream disease Pokkuri death syndrome SUNDS sudden unexplained nocturnal death syndrome disease_ontology DOID:0050451 OMIM mapping confirmed by DO. [SN]. Brugada syndrome A peroxisomal disease that is characterized by cortical atrophy, microcephaly, dysmorphic facies, muscular hypotonia and intellectual disability and has_material_basis_in mutation in the MVK gene that results in deficiency of mevalonate kinase and impaired cholesterol. biosynthesis. GARD:3588 ICD10CM:M04.1 MESH:D054078 NCI:C84890 OMIM:610377 ORDO:29 SNOMEDCT_US_2020_03_01:124327008 SNOMEDCT_US_2020_03_01:234538002 UMLS_CUI:C0342731 UMLS_CUI:C0398691 UMLS_CUI:C1959626 Mevalonate Kinase Deficiency disease_ontology DOID:0050452 OMIM mapping confirmed by DO. [SN]. mevalonic aciduria A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation. GARD:12291 ICD10CM:Q04.3 MESH:D054082 NCI:C103921 OMIM:300067 OMIM:300215 OMIM:607432 OMIM:611603 OMIM:614019 OMIM:615191 ORDO:102009 SNOMEDCT_US_2020_03_01:204036008 SNOMEDCT_US_2020_03_01:23024003 UMLS_CUI:C0266463 UMLS_CUI:C0266483 disease_ontology DOID:0050453 Xref MGI. OMIM mapping confirmed by DO. [SN]. lissencephaly A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain. MESH:D054091 OMIM:300049 OMIM:608097 OMIM:608098 OMIM:612881 OMIM:615544 ORDO:98892 SNOMEDCT_US_2020_03_01:448227009 SNOMEDCT_US_2020_03_01:816068000 UMLS_CUI:C1848213 UMLS_CUI:C1868720 periventricular heterotopia disease_ontology DOID:0050454 Xref MGI. OMIM mapping confirmed by DO. [SN]. periventricular nodular heterotopia A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin. GARD:9520 ICD10CM:A31.1 MESH:D054312 NCI:C84604 SNOMEDCT_US_2020_03_01:186343005 UMLS_CUI:C0085568 Bairnsdale ulcer Daintree ulcer Mossman ulcer Searl ulcer Searle's ulcer disease_ontology DOID:0050456 Buruli ulcer disease A male infertility disease characterized by male sterility, has_material_basis_in azospermia without abnormal sexual development. GARD:8406 MESH:D054331 SNOMEDCT_US_2020_03_01:73465006 UMLS_CUI:C1384583 DEL CASTILLO SYNDROME Germinal Cell Aplasia disease_ontology DOID:0050457 OMIM mapping confirmed by DO. [SN]. Sertoli cell-only syndrome A myelodysplastic/myeloproliferative neoplasm that is characterized by the uncontrolled growth of monocytes. GARD:9884 ICD10CM:C93.3 MESH:D054429 NCI:C9233 OMIM:607785 SNOMEDCT_US_2020_03_01:445227008 UMLS_CUI:C0349639 disease_ontology DOID:0050458 OMIM mapping confirmed by DO. [SN]. juvenile myelomonocytic leukemia A phosphorus metabolism disease characterized by hyperphosphatemia and abnormal deposits of phosphate and calcium in joints and soft tissues, results from abnomral phosphorus metabolism and has_material_basis_in mutations in the FGF23, GALNT3 or KL gene. MESH:D054559 NCI:C113750 SNOMEDCT_US_2020_03_01:20165001 UMLS_CUI:C0085681 disease_ontology DOID:0050459 hyperphosphatemia A chromosomal deletion syndrome that is characterized by distinct craniofacial features, hypotonia and intellectual disability and has_material_basis_in a microdeletion of the short arm of chromosome 4. DOID:6684 GARD:7896 ICD10CM:Q93.3 MESH:D054877 NCI:C35528 OMIM:194190 ORDO:280 SNOMEDCT_US_2020_03_01:17122004 UMLS_CUI:C0796117 UMLS_CUI:C1956097 4p deletion syndrome PITT SYNDROME Pitt-Rogers-Danks Syndrome chromosome 4p16.3 deletion syndrome disease_ontology DOID:0050460 OMIM mapping confirmed by DO. [LS]. Wolf-Hirschhorn syndrome A lysosomal storage disease that is characterized by delayed speech at 2-3 years of age, has_material_basis_in mutations in the AGA gene that result in the absence or shortage of the aspartylglucosaminidase enzyme in lysosomes, preventing the normal breakdown of glycoproteins. GARD:5854 ICD10CM:E77.1 MESH:D054880 NCI:C61273 OMIM:208400 SNOMEDCT_US_2020_03_01:54954004 UMLS_CUI:C0268225 aspartylglucosaminidase deficiency aspartylglycosaminuria glycosylasparaginase deficiency disease_ontology DOID:0050461 OMIM mapping confirmed by DO. [SN]. aspartylglucosaminuria MESH:D054880 A syndrome that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene. OMIM:201750 OMIM:207410 SNOMEDCT_US_2020_03_01:62964007 trapezoidocephaly-synostosis syndrome disease_ontology DOID:0050462 OMIM mapping confirmed by DO. [SN]. Antley-Bixler syndrome MESH:D054882 An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur. GARD:10027 MESH:D055036 NCI:C120205 NCI:C84609 OMIM:114290 ORDO:140 SNOMEDCT_US_2020_03_01:74928006 UMLS_CUI:C1861922 UMLS_CUI:C1861923 Acampomelic Campomelic Dysplasia disease_ontology DOID:0050463 OMIM mapping confirmed by DO. [SN]. campomelic dysplasia A lipid storage disease that is characterized by abnormalities in swallowing, cognition, joint function, and central nervous system due to a deficiency in the enzyme ceramidase that results in sphingolipids deposition. GARD:6426 MESH:D055577 NCI:C84710 OMIM:228000 SNOMEDCT_US_2020_03_01:79935000 UMLS_CUI:C0268255 Farber disease N-laurylsphingosine deacylase deficiency acid ceramidase deficiency disease_ontology DOID:0050464 OMIM mapping confirmed by DO. [SN]. Farber lipogranulomatosis A Lynch syndrome that is characterized by a propensity to develop cancers of the gastrointestinal tract, genitourinary tract, and skin that has_material_basis_in mutations in DNA mismatch repair genes. GARD:6821 MESH:D055653 NCI:C84905 OMIM:158320 SNOMEDCT_US_2020_03_01:403824007 UMLS_CUI:C1321489 disease_ontology DOID:0050465 OMIM mapping confirmed by DO. [SN]. Muir-Torre syndrome A syndrome that is characterized by increased risk of aortic aneurysm and dissection, elongated limbs, hypertelorism, bifid uvula and easy skin bruising due to mutations in TGFB3 that results in connective tissue defects. GARD:10788 MESH:D055947 NCI:C75006 ORDO:60030 SNOMEDCT_US_2020_03_01:446263001 UMLS_CUI:C1836635 UMLS_CUI:C2697932 disease_ontology DOID:0050466 Xref MGI. OMIM mapping confirmed by DO. [SN]. Loeys-Dietz syndrome A skin disease that is characterized by areas of sharply demarcated, brown hyperkeratosis and has_material_basis_in mutations in genes encoding for connexin channels proteins in the epidermis. MESH:D056266 NCI:C84696 OMIM:PS133200 ORDO:317 SNOMEDCT_US_2020_03_01:70041004 UMLS_CUI:C0265961 UMLS_CUI:C1851480 Erythrokeratodermia Figurata Variabilis Greither Disease disease_ontology DOID:0050467 OMIM mapping confirmed by DO. [SN]. erythrokeratodermia variabilis MESH:D056266 A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached. GARD:184 ICD10CM:L60.5 MESH:D056684 NCI:C85238 OMIM:153300 SNOMEDCT_US_2020_03_01:400211001 UMLS_CUI:C0221348 disease_ontology DOID:0050468 OMIM mapping confirmed by DO. [SN]. yellow nail syndrome A RASopathy characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays. GARD:1550 MESH:D056685 NCI:C84652 OMIM:218040 SNOMEDCT_US_2020_03_01:205803001 UMLS_CUI:C0587248 FCS SYNDROME Faciocutaneoskeletal Syndrome disease_ontology DOID:0050469 OMIM mapping confirmed by DO. [SN]. Costello syndrome A syndrome that is characterized by protuberant and low-set ears, flaring nostrils, thick lips, enlarged secondary sex organs and overwhelming insulin resistance and has_material_basis_in mutation within the INSR gene causing abnormalities in the insulin receptor. MESH:D056731 NCI:C131000 NCI:C84676 OMIM:246200 ORDO:508 SNOMEDCT_US_2020_03_01:111307005 SNOMEDCT_US_2020_03_01:33559001 UMLS_CUI:C0265344 UMLS_CUI:C0271695 Leprechaunism disease_ontology DOID:0050470 OMIM mapping confirmed by DO. [SN]. Donohue syndrome A syndrome characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity. GARD:1119 MESH:D056733 NCI:C4705 OMIM:160980 OMIM:605244 OMIM:608837 ORDO:1359 SNOMEDCT_US_2020_03_01:733491005 UMLS_CUI:C0406810 UMLS_CUI:C1854540 UMLS_CUI:C2607929 Carney Complex, Type 1 Carney Complex, Type 2 Carney Syndrome Carney complex variant LAMB Syndrome NAME Syndrome disease_ontology DOID:0050471 Xref MGI. OMIM mapping confirmed by DO. [SN]. Carney complex A hair disease that is characterized by short, easily broken hair that results in alopecia and has_material_basis_in mutations in genes for type II hair cortex keratins. GARD:93 ICD10CM:Q84.1 MESH:D056734 NCI:C84894 OMIM:158000 SNOMEDCT_US_2020_03_01:69488000 UMLS_CUI:C0546966 disease_ontology DOID:0050472 OMIM mapping confirmed by DO. [SN]. monilethrix A syndrome that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene. MESH:D056769 NCI:C84549 OMIM:203800 SNOMEDCT_US_2020_03_01:63702009 UMLS_CUI:C0268425 disease_ontology DOID:0050473 OMIM mapping confirmed by DO. [SN]. Alstrom syndrome MESH:D056769 A skin disease that is characterized by chronic skin inflammation, trichorrhexis invaginata, atopic dermatitis and has_material_basis_in mutations in the SPINK5 gene resulting in reduced capacity to inhibit serine proteases expressed in the skin. GARD:7182 MESH:D056770 NCI:C84922 OMIM:256500 ORDO:634 SNOMEDCT_US_2020_03_01:312514006 UMLS_CUI:C0265962 disease_ontology DOID:0050474 OMIM mapping confirmed by DO. [SN]. Netherton syndrome A syndrome characterized by short stature, bachycephaly and other facial abnormalities, brachydactyly, joint stiffness and distinctive ocular abnormalities. GARD:4936 MESH:D056846 NCI:C85226 OMIM:277600 OMIM:608328 OMIM:613195 OMIM:614819 ORDO:3449 SNOMEDCT_US_2020_03_01:205801004 UMLS_CUI:C0265313 UMLS_CUI:C1869114 UMLS_CUI:C1869115 GEMSS syndrome Marchesani-Weill Syndrome Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome congenital mesodermal dystrophy disease_ontology DOID:0050475 Xref MGI. OMIM mapping confirmed by DO. [LS]. Weill-Marchesani syndrome A lipid metabolism disorder that has_material_basis_in X-linked inheritance of the tafazzin gene and is characterized by decreased production of an enzyme required to produce cardiolipin. GARD:5890 ICD10CM:E78.71 MESH:D056889 NCI:C84585 OMIM:302060 SNOMEDCT_US_2020_03_01:297231002 UMLS_CUI:C0574083 3-methylglutaconicaciduria type 2 3-methylglutaconicaciduria type II MGA Type 2 MGA type II disease_ontology DOID:0050476 OMIM mapping confirmed by DO. [SN]. Barth syndrome MESH:D056889 A renal tubular transport disease that is characterized by hypertension and hypokalemia caused by dysregulation of epithelial sodium channels causing over expression of the channel. GARD:7381 MESH:D056929 NCI:C84827 OMIM:177200 SNOMEDCT_US_2020_03_01:707749005 UMLS_CUI:C0221043 Liddle's syndrome Pseudoaldosteronism disease_ontology DOID:0050477 OMIM mapping confirmed by DO. [SN]. Liddle syndrome A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash. DOID:0050028 DOID:0050029 DOID:0050030 DOID:0050057 DOID:0050058 Rat-Flea Typhus Rickettsia felis spotted fever Urban Typhus of Malaya cat flea rickettsiosis fleaborne typhus murine typhus toulon typhus urban typhus disease_ontology Shop typhus DOID:0050481 endemic typhus A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia. GARD:120 Sennetsu ehrlichiosis disease_ontology DOID:0050485 sennetsu fever A skin disease that is characterized by a rash that results from a variety of causes including bacteria, viruses, toxins, drugs and autoimmune disorders. ICD10CM:R21 ICD9CM:782.1 MESH:D005076 NCI:C111884 SNOMEDCT_US_2020_03_01:112625008 UMLS_CUI:C0015230 Rash exanthema disease_ontology DOID:0050486 exanthem A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck. ICD10CM:B08.2 ICD9CM:058.1 MESH:D005077 SNOMEDCT_US_2020_03_01:54385001 UMLS_CUI:C0015231 Roseola Infantum Sixth Disease disease_ontology DOID:0050495 exanthema subitum A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions. GARD:13103 ICD10CM:C91.5 MESH:D015459 NCI:C3184 SNOMEDCT_US_2020_03_01:77430005 UMLS_CUI:C0023493 Adult T-cell leukemia/lymphoma disease_ontology DOID:0050523 adult T-cell leukemia A diabetes mellitus that has_material_basis_in autosomal dominant inheritance of mutations in the MODY genes impacting beta-cell function, typically occurring before 25 years of age and caused by primary insulin secretion defects. GARD:3697 ICD10CM:E11.8 KEGG:04950 OMIM:606391 ORDO:552 MODY Mason-type diabetes disease_ontology DOID:0050524 Xref MGI. OMIM mapping confirmed by DO. [SN]. maturity-onset diabetes of the young A syndrome that is characterized by brittle hair, short stature, decreased fertility and cognitive impairment without photosensitivity has_material_basis_in mutations in the TTDN1 gene. OMIM:234050 AMISH BRITTLE HAIR BRAIN SYNDROME BIDS syndrome HAIR-BRAIN SYNDROME TTD4 disease_ontology DOID:0050528 OMIM mapping confirmed by DO. [SN]. nonphotosensitive trichothiodystrophy 4 A spinal muscular atrophy that is characterized by progressive muscular weakness and motor disability that typically presents in the third decade of life and has_material_basis_in mutations in the SMN1 or SMN2 genes that are required for the survival of motor neurons. ICD10CM:G12.1 MESH:C563948 OMIM:271150 ORDO:83420 UMLS_CUI:C1838230 SMA4 SPINAL MUSCULAR ATROPHY, ADULT FORM SPINAL MUSCULAR ATROPHY, TYPE IV spinal muscular atrophy 4 disease_ontology DOID:0050529 OMIM mapping confirmed by DO. [SN]. adult spinal muscular atrophy A hereditary night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves. ICD10CM:H53.63 ICD9CM:368.61 MESH:C537743 OMIM:PS310500 ORDO:215 SNOMEDCT_US_2020_03_01:193687000 UMLS_CUI:C1306122 congenital essential nyctalopia disease_ontology DOID:0050534 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital stationary night blindness A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina. GARD:1613 ICD10CM:H35.00 ICD9CM:362.10 OMIM:PS133780 ORDO:891 SNOMEDCT_US_2020_03_01:193355009 UMLS_CUI:C0004608 FEVR familial exudative vitreoretinopathy disease_ontology DOID:0050535 Xref MGI. OMIM mapping confirmed by DO. [SN]. exudative vitreoretinopathy A cataract that is characterized by a distinctive discoid lens opacity situated posteriorly and adjacent to the posterior capsule. CATARACT, POSTERIOR POLAR disease_ontology DOID:0050537 OMIM mapping confirmed by DO. [SN]. posterior polar cataract A Charcot-Marie-Tooth disease characterized by demyelination of the peripheral nerve axons. GARD:12433 hereditary motor and sensory neuropathy type 1 disease_ontology DOID:0050538 OMIM mapping confirmed by DO. [SN]. Charcot-Marie-Tooth disease type 1 A Charcot-Marie-Tooth disease that is characterized by motor and sensory peripheral neuropathies caused by demyelination. OMIM:145900 DEJERINE-SOTTAS NEUROPATHY DEJERINE-SOTTAS SYNDROME disease_ontology DOID:0050540 OMIM mapping confirmed by DO. [SN]. Charcot-Marie-Tooth disease type 3 An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body. disease_ontology DOID:0050544 Xref MGI. OMIM mapping confirmed by DO. [SN]. hypermethioninemia A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen. GARD:10875 OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 ORDO:450 heterotaxia situs ambiguus disease_ontology DOID:0050545 Xref MGI. OMIM mapping confirmed by DO. [SN]. visceral heterotaxy An adrenal gland disease that is characterized by cortisol deficiency, hypoaldosteronism and excessive or insufficient sex hormones, has_material_basis_in the mutation in the gene for 21-hydroxylase, 11beta-hydroxylase, 3beta-hydroxysteroid, 17alpha-hydroxylase or 20,22-desmolase. OMIM:613743 ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL, PARTIAL OR COMPLETE P450scc DEFICIENCY disease_ontology DOID:0050546 OMIM mapping confirmed by DO. [SN]. congenital adrenal insufficiency A thyroid gland medullary carcinoma that has_material_basis_in autosomal dominant inheritance. OMIM:155240 THYROID CARCINOMA, FAMILIAL MEDULLARY disease_ontology DOID:0050547 OMIM mapping confirmed by DO. [SN]. familial medullary thyroid carcinoma A neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages. OMIM:PS162400 familial dysautonomia, type II hereditary sensory and autonomic neuropathy disease_ontology DOID:0050548 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary sensory neuropathy A syndrome that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy that has_material_basis_in homozygous or compound heterozygous mutation in PSMB8 on chromosome 6p21.32. GARD:10988 OMIM:256040 ORDO:324999 JOINT CONTRACTURES, MUSCULAR ATROPHY, MICROCYTIC ANEMIA, AND PANNICULITIS-INDUCED LIPODYSTROPHY disease_ontology DOID:0050553 JMP syndrome A sideroblastic anemia that is characterized by decreased production of hemoglobin and ataxia and has_material_basis_in the mutation in the ABCB7 gene. DOID:0060064 OMIM:301310 Anemia sideroblastic and spinocerebellar ataxia X-linked sideroblastic anaemia and ataxia X-linked sideroblastic anaemia with ataxia X-linked sideroblastic anemia and ataxia disease_ontology DOID:0050554 OMIM mapping confirmed by DO. [SN]. X-linked sideroblastic anemia with ataxia A muscular dystrophy that is characterized by diminished muscle tone (hypotonia), progressive muscle weakness and degeneration (atrophy), abnormally fixed joints, spinal rigidity, and delays in reaching motor milestones such as sitting or standing unassisted. GARD:9138 ICD9CM:359.0 OMIM:254100 ORDO:97242 SNOMEDCT_US_2020_03_01:193221009 UMLS_CUI:C2937300 disease_ontology DOID:0050557 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital muscular dystrophy A congenital muscular dystrophy that is characterized by muscle weakness and respiratory depression and has_material_basis_in mutation in the COL6A1, COL6A2 and COL6A3 that produce components of type VI collagen. GARD:4769 OMIM:254090 ULLRICH DISEASE Ullrich scleroatonic muscular dystrophy disease_ontology DOID:0050558 OMIM mapping confirmed by DO. [SN]. Ullrich congenital muscular dystrophy A congenital muscular dystrophy-dystroglycanopathy type A that is characterized by muscle weakness, failure to thrive, severe intellectual and developmental disability, impaired vision and cardiac abnormalities and has_material_basis_in mutation in the FKTN gene that produces the fukutin protein. GARD:6475 OMIM:253800 ORDO:272 disease_ontology DOID:0050559 OMIM mapping confirmed by DO. [SN]. Fukuyama congenital muscular dystrophy A congenital muscular dystrophy that is characterized by hypotonia, seizures, severe intellectual and developmental disability, eye abnormalities and early death and has_material_basis_in mutations in multiple genes including POMT1, POMT2, ISPD, FKTN, FKRP, and LARGE1. GARD:2599 MESH:D058494 HARD syndrome cerebroocular dysplasia-muscular dystrophy syndrome disease_ontology DOID:0050560 OMIM mapping confirmed by DO. [SN]. Walker-Warburg syndrome A childhood electroclinical syndrome that is characterized by frequent seizures and intellectual disability that present in early childhood. GARD:9912 OMIM:606369 ORDO:2382 Lennox syndrome disease_ontology DOID:0050561 Lennox-Gastaut syndrome An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms. nonsyndromic hearing loss nonsyndromic hereditary hearing loss disease_ontology DOID:0050563 nonsyndromic deafness A nonsyndromic deafness characterized by an X-linked inheritance mode. ICD10CM:H90.3 OMIM:PS304500 ORDO:90625 X-linked deafness disease_ontology DOID:0050566 OMIM mapping confirmed by DO. [SN]. X-linked nonsyndromic deafness A physical disorder that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development. OMIM:PS119530 disease_ontology DOID:0050567 Xref MGI. OMIM mapping confirmed by DO. [SN]. orofacial cleft A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together. GARD:12174 GARD:6798 OMIM:122600 OMIM:277300 OMIM:608681 OMIM:609813 OMIM:613686 ORDO:1797 ORDO:2311 Jarcho-Levin syndrome spondylocostal dysostosis, autosomal recessive 3 spondylothoracic dysostosis spondylothoracic dysplasia disease_ontology DOID:0050568 Xref MGI. OMIM mapping confirmed by DO. [SN]. spondylocostal dysostosis A syndrome characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability. GARD:8562 ICD10CM:Q87.1 OMIM:PS210600 ORDO:808 Harper's syndrome Virchow-Seckel dwarfism bird-headed dwarfism microcephalic primordial dwarfism disease_ontology DOID:0050569 Xref MGI. OMIM mapping confirmed by DO. [SN]. Seckel syndrome A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells. GARD:10790 ICD10CM:H35.5 ORDO:1872 cone-rod retinal dystrophy disease_ontology DOID:0050572 Xref MGI. OMIM mapping confirmed by DO. [SN]. cone-rod dystrophy An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage. GARD:10761 disease_ontology DOID:0050573 2-hydroxyglutaric aciduria An 2-hydroxyglutaric aciduria that involves damage to cerebellum affecting movement coordination resulting in problems with balance and muscle coordination (ataxia). GARD:10472 OMIM:236792 ORDO:79314 L-2-HYDROXYGLUTARIC ACIDEMIA disease_ontology DOID:0050574 L-2-hydroxyglutaric aciduria An 2-hydroxyglutaric aciduria that involves developmental delay, seizures, weak muscle tone (hypotonia), and abnormalities in the largest part of the brain (the cerebrum), which controls many important functions such as muscle movement, speech, vision, thinking, emotion, and memory. GARD:5661 OMIM:PS600721 disease_ontology DOID:0050575 D-2-hydroxyglutaric aciduria A syndrome that is characterized by characterized by sagittal craniosynostosis and facial, ectodermal, and skeletal anomalies. OMIM:PS218330 Levin syndrome Sensenbrenner syndrome disease_ontology DOID:0050577 OMIM mapping confirmed by DO. [SN]. cranioectodermal dysplasia A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings. OMIM:613587 disease_ontology DOID:0050578 OMIM mapping confirmed by DO. [SN]. occult macular dystrophy A dysostosis characterized by short fingers and toes. GARD:11913 ORDO:294937 disease_ontology DOID:0050581 Xref MGI. OMIM mapping confirmed by DO. [SN]. brachydactyly MESH:D059327 An impulse control disorder that involves the uncontrollable plucking of ones hair. GARD:7803 MESH:D014256 OMIM:613229 disease_ontology DOID:0050587 OMIM mapping confirmed by DO. [SN]. trichotillomania A congenital muscular dystrophy characterized by muscle weakness, cognitive impairment and brain abnormalities and has_material_basis_in mutation to the POMT1 gene that encodes O-mannosyltransferase. ICD10CM:G71.2 OMIM:613151 OMIM:613152 OMIM:613155 OMIM:613156 OMIM:615351 OMIM:616094 OMIM:PS613155 ORDO:370953 CMD due to dystroglycanopathy disease_ontology DOID:0050588 Xref MGI. muscular dystrophy-dystroglycanopathy An intestinal disease characterized by inflammation located in all parts of digestive tract. EFO:0003767 KEGG:05321 MESH:D015212 NCI:C3138 OMIM:PS266600 SNOMEDCT_US_2020_03_01:155759008 UMLS_CUI:C0021390 disease_ontology DOID:0050589 Xref MGI. OMIM mapping confirmed by DO. [SN]. inflammatory bowel disease A neutropenia characterized by a maturation arrest of granulopoiesis at the level or promyelocytes and early onset of severe bacterial infections. GARD:13592 ICD10CM:D70 OMIM:PS202700 ORDO:42738 disease_ontology DOID:0050590 Xref MGI. OMIM mapping confirmed by DO. [SN]. severe congenital neutropenia A tooth disease characterized by failure to develop on or more missing teeth. ICD10CM:K00.0 ICD9CM:520.0 MESH:D000848 OMIM:106600 OMIM:150400 OMIM:313500 OMIM:602639 OMIM:604625 OMIM:610926 ORDO:2227 ORDO:99798 SNOMEDCT_US_2020_03_01:234951001 UMLS_CUI:C0399352 familial tooth agenesis hypodontia oligodontia selective tooth agenesis disease_ontology DOID:0050591 Xref MGI. tooth agenesis A bone development disease characterized by skeletal abnormalities and resulting in difficulty in breathing caused by mutations that result in ciliopathy. ICD10CM:Q77.2 OMIM:PS208500 ORDO:474 Jeune syndrome short-rib thoracic dysplasia with or without polydactyly thoracic pelvic phalangeal dystrophy disease_ontology DOID:0050592 OMIM mapping confirmed by DO. [SN]. asphyxiating thoracic dystrophy A parasitic helminthiasis infectious disease that has_material_basis_in Taenia solium or has_material_basis_in Taenia saginata, which are transmitted by ingestion of undercooked contaminated meat. DOID:10076 ICD10CM:B68.1 ICD9CM:123.2 SNOMEDCT_US_2020_03_01:69163003 UMLS_CUI:C0152073 disease_ontology Beef tapeworm infection Infection by Taeniarhynchus saginatus Taenia saginata infectious disease DOID:0050596 taeniasis A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia. DOID:13692 DOID:13721 DOID:3468 ICD10CM:B65.1 ICD10CM:B65.2 ICD9CM:120.1 ICD9CM:120.2 MESH:D012554 MESH:D012555 NCI:C35001 NCI:C35002 NCI:C35364 OMIM:181460 ORDO:1247 SNOMEDCT_US_2020_03_01:187114003 SNOMEDCT_US_2020_03_01:52179003 SNOMEDCT_US_2020_03_01:750009 UMLS_CUI:C0036329 UMLS_CUI:C0036330 UMLS_CUI:C0276932 Katayama fever Schistosoma japonicum infection Schistosoma mansoni infectious disease schistosomiasis japonica disease_ontology DOID:0050597 Xref MGI. intestinal schistosomiasis A tuberculosis that occurs at body sites other than the lung. disease_ontology DOID:0050598 extrapulmonary tuberculosis An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas. disease_ontology DOID:0050599 abdominal tuberculosis A syndrome that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB). OMIM:600501 ABCDS albinism, black lock, cell migration disorder of the neurocytes of the gut, and deafness disease_ontology DOID:0050600 OMIM mapping confirmed by DO. [SN]. ABCD syndrome A syndrome that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63. GARD:384 OMIM:103285 acro-dermato-ungual-lacrimal-tooth syndrome disease_ontology DOID:0050601 OMIM mapping confirmed by DO. [SN]. ADULT syndrome A syndrome characterized by achalasia, adrenal insufficiency and alacrima and has_material_basis_in mutations in the AAAS gene that encodes ALADIN within the nuclear envelope and results in dysfunction of the autonomic nervous system. GARD:457 OMIM:231550 AAAS Achalasia-Addisonianism-Alacrimia syndrome Allgrove Syndrome disease_ontology DOID:0050602 OMIM mapping confirmed by DO. [SN]. triple-A syndrome An osteochondrodysplasia characterized by a lack of formation of the distal extremities has_material_basis_in mutation in the LMBR1 gene. GARD:376 OMIM:200500 Acheiropodia Horn-Kolb Syndrome disease_ontology DOID:0050603 OMIM mapping confirmed by DO. [SN]. acheiropody A metal metabolism disorder characterized by dermatitis around bodily openings and the tips of fingers and toes, alopecia and diarrhea and has_material_basis_in mutation in the SLC39A4 gene that encodes a zinc uptake protein and results in zinc deficiency. GARD:5723 OMIM:201100 disease_ontology DOID:0050605 acrodermatitis enteropathica A keratosis that has_material_basis_in mutations in the ATP2A2 gene. OMIM:101900 Acrokeratosis verruciformis of Hopf Hopf disease disease_ontology DOID:0050606 OMIM mapping confirmed by DO. [SN]. acrokeratosis verruciformis An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract. disease_ontology DOID:0050615 respiratory system cancer A respiratory system cancer that is located_in the paranasal sinuses. DOID:1354 DOID:2442 DOID:2765 DOID:2767 DOID:4689 MESH:D010255 NCI:C6014 NCI:C6017 NCI:C6018 NCI:C6019 NCI:C8193 UMLS_CUI:C0280334 UMLS_CUI:C0854995 UMLS_CUI:C1335336 UMLS_CUI:C1335337 UMLS_CUI:C1335340 Epidermoid carcinoma of the paranasal sinus Mucoepidermoid carcinoma of Accessory sinus adenoid cystic carcinoma of Accessory sinus paranasal sinus adenocarcinoma paranasal sinus adenoid cystic carcinoma paranasal sinus mucoepidermoid carcinoma paranasal sinus squamous cell carcinoma disease_ontology adenoid cystic carcinoma of paranasal sinus squamous cell carcinoma of paranasal sinus DOID:0050619 paranasal sinus cancer An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm. disease_ontology DOID:0050621 respiratory system benign neoplasm An organ system benign neoplasm that is located_in reproductive system organs. disease_ontology DOID:0050622 reproductive organ benign neoplasm A urinary system benign neoplasm located_in the bladder including papillomas, leiomyomas, fibromas, hemangiomas, neurofibromas and lipomas. disease_ontology DOID:0050623 bladder benign neoplasm An organ system benign neoplasm located_in gastrointestinal tract organs. disease_ontology DOID:0050624 gastrointestinal system benign neoplasm A hepatobiliary benign neoplasm located_in the biliary tract. DOID:4609 NCI:C4441 SNOMEDCT_US_2020_03_01:126855001 UMLS_CUI:C0345913 extrahepatic bile duct neoplasm neoplasm of extrahepatic bile ducts tumor of the extrahepatic bile duct disease_ontology DOID:0050625 biliary tract benign neoplasm A syndrome that is a genetically heterogeneous encephalopathy characterized in its most severe form by cerebral atrophy, leukodystrophy, intracranial calcifications, chronic cerebrospinal fluid lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infections. GARD:575 ICD10CM:G31.8 OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 ORDO:51 Cree encephalitis disease_ontology DOID:0050629 Xref MGI. OMIM mapping confirmed by DO. [SN]. Aicardi-Goutieres syndrome An eye disease characterized by fundus hypopigmentation, decreased visual acuity, nystagmus, astigmatism, myopia and defective darkness adaptation and has_material_basis_in mutation in the CACNA1F gene. GARD:10574 MESH:C562664 OMIM:300600 FORSIUS-ERIKSSON TYPE OCULAR ALBINISM Forsius-Eriksson syndrome disease_ontology DOID:0050630 Aland Island eye disease A syndrome that has_material_basis_in mutation at is in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement. GARD:5617 MESH:C537047 OMIM:300523 ORDO:59 AHDS ALLAN-HERNDON SYNDROME disease_ontology DOID:0050631 OMIM mapping confirmed by DO. [SN]. Allan-Herndon-Dudley syndrome A syndrome characterized by abnormal pigmentation of the skin, hair and eyes. GARD:10958 ICD10CM:E70.3 MESH:D016115 OMIM:PS203100 ORDO:55 disease_ontology DOID:0050632 Xref MGI. OMIM mapping confirmed by DO. [SN]. oculocutaneous albinism An eye disease that is characterized by reduced pigmentation of the iris and the resulting impairment of visual acuity without significantly affecting the color of skin or hair and has_material_basis in mutation in the GPR143 gene that encodes segments of the melanosomes that stores melanin. MESH:D016117 OMIM:300500 disease_ontology DOID:0050633 ocular albinism An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis. GARD:132 OMIM:105250 OMIM:613955 ORDO:137807 PCA familial primary localized cutaneous amyloidosis disease_ontology DOID:0050639 Xref MGI. OMIM mapping confirmed by DO. [SN]. primary cutaneous amyloidosis A vascular disease that is characterized by generalized calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall. GARD:8380 MESH:C537440 OMIM:208000 OMIM:614473 ORDO:51608 generalized arterial calcification of infancy idiopathic infantile arterial calcification infantile arteriosclerosis disease_ontology DOID:0050644 Xref MGI. OMIM mapping confirmed by DO. [SN]. arterial calcification of infancy A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta. GARD:774 MESH:C565942 OMIM:208050 disease_ontology DOID:0050645 OMIM mapping confirmed by DO. [SN]. arterial tortuosity syndrome A muscle tissue disease characterized by congenital joint contractures of hand and feet. GARD:786 OMIM:108120 OMIM:108145 OMIM:108200 OMIM:114300 OMIM:121050 OMIM:121070 OMIM:158300 OMIM:187370 OMIM:193700 OMIM:601680 OMIM:609128 OMIM:614335 OMIM:615065 ORDO:1147 ORDO:97120 Arthrogryposis Multiplex Congenita Freeman-Sheldon syndrome disease_ontology DOID:0050646 Xref MGI. OMIM mapping confirmed by DO. [SN]. distal arthrogryposis An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene. GARD:8756 MESH:C535388 OMIM:301835 ORDO:1187 SNOMEDCT_US_2020_03_01:702441001 UMLS_CUI:C0796028 ARTS Lethal ataxia with deafness and optic atrophy MRXS18 MRXSARTS fatal X-linked ataxia with deafness and loss of vision syndromic X-linked mental retardation 18 syndromic X-linked mental retardation Arts type disease_ontology DOID:0050647 OMIM mapping confirmed by DO. [SN]. Arts syndrome An osteochondrodysplasia that is characterized by specific patterns of aplasia/hypoplasia of humeri, femora, spine in newborns. OMIM:108720 OMIM:108721 OMIM:256050 disease_ontology DOID:0050648 OMIM mapping confirmed by DO. [SN]. atelosteogenesis A metal metabolism disorder that is characterized by transferrin deficiency, microcytic anemia, and iron loading, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the structural gene for transferrin on chromosome 3q22. GARD:9595 NCI:C125693 OMIM:209300 ORDO:1195 familial hypotransferrinemia disease_ontology DOID:0050649 OMIM mapping confirmed by DO. [SN]. atransferrinemia An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes. GARD:9740 OMIM:607554 OMIM:608583 OMIM:608988 OMIM:611493 OMIM:611494 OMIM:612201 OMIM:612240 OMIM:613055 OMIM:613980 OMIM:614022 OMIM:614049 OMIM:614050 OMIM:615377 OMIM:615378 OMIM:615770 OMIM:PS608583 ORDO:334 ATFB disease_ontology DOID:0050650 Xref MGI. familial atrial fibrillation A congenital heart septal defect characterized by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the atrial septum and the muscular portion of the ventricular septum, thus allowing extra blood to circulate the lungs. GARD:802 ICD10CM:Q21.2 ICD9CM:745.6 MESH:D004694 OMIM:600309 OMIM:606215 OMIM:614430 OMIM:614474 ORDO:98722 SNOMEDCT_US_2020_03_01:204322008 UMLS_CUI:C0014116 AVCD AVSD ECD atrioventricular canal defect endocardial cushion defect disease_ontology DOID:0050651 Xref MGI. OMIM mapping confirmed by DO. [SN]. atrioventricular septal defect A synostosis characterized by coronal craniosynostosis, short stature, and aplasia or hypoplasia of the radial bone. GARD:1602 MESH:C536788 OMIM:218600 ORDO:1223 SNOMEDCT_US_2020_03_01:77608001 UMLS_CUI:C0265308 disease_ontology DOID:0050654 OMIM mapping confirmed by DO. [SN]. Baller-Gerold syndrome A hypothyroidism that is characterized by thyroid dysgenesis, cleft palate, spiky hair and bifid epiglottis, has_material_basis_in homozygous mutation in the FKHL15 gene on chromosome 9q22. OMIM:241850 HYPOTHYROIDISM, ATHYROIDAL, WITH SPIKY HAIR AND CLEFT PALATE disease_ontology DOID:0050655 OMIM mapping confirmed by DO. [SN]. Bamforth-Lazarus syndrome A syndrome that is characterized by congenital microcephaly, intracranial calcifications, severe developmental delay, simplified gyration and polymicrogyria that has_material_basis_in homozygous or compound heterozygous mutation in OCLN on chromosome 5q13.2. GARD:12426 OMIM:251290 ORDO:1229 BLC-PMG BLCPMG Baraitser-Brett-Piesowicz syndrome Baraitser-Reardon syndrome PTORCH1 band-like calcification with simplified gyration and polymicrogyria bilateral band-like calcification with polymicrogyria microcephaly-intracranial calcification-intellectual disability syndrome disease_ontology DOID:0050656 pseudo-TORCH syndrome 1 A syndrome that is characterized by macrocephaly, multiple noncancerous tumors and hamartomas, and dark freckles on the penis, and has_material_basis_in heterozygous germline mutation in the PTEN gene on chromosome 10q23. GARD:5887 ICD10CM:Q87.89 MESH:D006223 NCI:C3939 OMIM:158350 ORDO:109 Bannayan-Zonana syndrome Riley-Smith syndrome Ruvalcaba-Myhre-Smith syndrome disease_ontology DOID:0050657 OMIM mapping confirmed by DO. [SN]. Bannayan-Riley-Ruvalcaba syndrome A syndrome that is characterized by leukonychia, wart-like skin growths, palmoplantar keratoderma and hearing loss, has_material_basis_in heterozygous mutation in the GJB2 gene on chromosome 13q12. OMIM:149200 KNUCKLE PADS, LEUKONYCHIA, AND SENSORINEURAL DEAFNESS disease_ontology DOID:0050658 OMIM mapping confirmed by DO. [SN]. Bart-Pumphrey syndrome A basal ganglia disease that is characterized by recurrent subacute encephalopathy, has_symptom confusion, has_symptom seizure, has_symptom ataxia, has_symptom dystonia, has_symptom supranuclear facial palsy, has_symptom external ophthalmoplegia, and has_symptom dysphagia. MESH:C537658 OMIM:607483 disease_ontology DOID:0050659 OMIM mapping confirmed by DO. [SN]. biotin-responsive basal ganglia disease A syndrome that is characterized by cutis gyrata, acanthosis nigricans and craniosynostosis, has_material_basis_in heterozygous mutation in the FGFR2 gene on chromosome 10q26. GARD:332 OMIM:123790 disease_ontology DOID:0050660 OMIM mapping confirmed by DO. [SN]. Beare-Stevenson cutis gyrata syndrome A macular degeneration that it is characterized by the disruption of cells in a small area near the center of the retina, the macula and may cause progressive vision loss. GARD:10120 GARD:182 ICD10CM:H35.5 MESH:D057826 OMIM:153700 OMIM:153840 OMIM:608161 OMIM:616151 OMIM:616152 ORDO:1243 ORDO:99000 Best disease Best macular dystrophy juvenile-onset vitelliform macular dystrophy disease_ontology DOID:0050661 Xref MGI. OMIM mapping confirmed by DO. [SN]. vitelliform macular dystrophy A macular degeneration that is characterized by central vision loss, an absent electrooculogram light rise and a reduced electroretinogram, has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the BEST1 gene on chromosome 11q12. MESH:C567518 OMIM:611809 autosomal recessive bestrophinopathy disease_ontology DOID:0050662 OMIM mapping confirmed by DO. [SN]. bestrophinopathy A congenital muscular dystrophy that is characterized by myopathy and joint contractures that progresses slowly, has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the COL6A1 gene, the COL6A2 gene, or the COL6A3 gene. GARD:873 OMIM:158810 benign congenital muscular dystrophy disease_ontology DOID:0050663 OMIM mapping confirmed by DO. [SN]. Bethlem myopathy A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction. disease_ontology DOID:0050665 fetal alcohol syndrome A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure. disease_ontology DOID:0050666 partial fetal alcohol syndrome A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure. ARND static encephalopathy disease_ontology DOID:0050667 alcohol-related neurodevelopmental disorder A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements. disease_ontology DOID:0050669 spastic cerebral palsy A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing. GARD:10451 OMIM:605388 hypotonic cerebral palsy disease_ontology DOID:0050670 ataxic cerebral palsy A steroid inherited metabolic disorder characterized by abnormal conversion of cholesterol into bile acids which occurs predominantly in the liver. ICD10CM:K76.8 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency CBA cholestasis with delta(4)-3-oxosteroid-5-beta-reductase deficiency disease_ontology DOID:0050674 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital bile acid synthesis defect A syndrome that is characterized by intellectual disability, hypotonia, hyperactivity and facies, has_material_basis_in heterozygous mutation in the KCNK9 gene on chromosome 8q24. GARD:10358 MESH:C567357 OMIM:612292 Birk-Barel mental retardation dysmorphism syndrome disease_ontology DOID:0050675 OMIM mapping confirmed by DO. [SN]. Birk-Barel syndrome A skin disease that is characterized by the development of skin papules on the head, face and upper torso, has_material_basis_in heterozygous mutation in the gene encoding folliculin on chromosome 17p11. GARD:2322 MESH:D058249 OMIM:135150 disease_ontology DOID:0050676 OMIM mapping confirmed by DO. [SN]. Birt-Hogg-Dube syndrome A syndrome characterized by familial granulomatous arthritis, uveitis and skin granulomas. It has_material_basis_in heterozygous mutations in the NOD2 gene. GARD:304 NCI:C116794 OMIM:186580 ARTHROCUTANEOUVEAL GRANULOMATOSIS BLAUS Jabs syndrome disease_ontology DOID:0050678 OMIM mapping confirmed by DO. [SN]. Blau syndrome An achromatopsia that is characterized by severely impaired color discrimination, low visual acuity, nystagmus, photophobia due to the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina and has_material_basis_in recessive X-linked inheritance. GARD:917 OMIM:303700 disease_ontology DOID:0050679 OMIM mapping confirmed by DO. [SN]. blue cone monochromacy An osteochondrodysplasia that is characterized by severe dwarfism, dislocated joints, club feet, distinctive facies and dysplastic tubular bones with boomerang-like bowing, has_material_basis_in heterozygous mutation in the FLNB gene on chromosome 3p14. GARD:933 OMIM:112310 disease_ontology DOID:0050680 OMIM mapping confirmed by DO. [SN]. Boomerang dysplasia An X-linked disease that is characterized by intellectual disability, truncal obesity, seizures, hypogonadism, developmental delay, distinctive facial features, tapered fingers and short toes and has_material_basis_in X-linked recessive inheritance of mutations in the PHF6 gene. GARD:936 MESH:C536575 NCI:C157122 OMIM:301900 ORDO:127 SNOMEDCT_US_2020_03_01:21634003 UMLS_CUI:C0265339 BFLS BORJ Borjeson syndrome MRXSBFL intellectual deficiency-epilepsy-endocrine disorders syndrome mental retardation, epilepsy, and endocrine disorder syndromic X-linked mental retardation Borjeson-Forssman-Lehmann type disease_ontology DOID:0050681 OMIM mapping confirmed by DO. [SN]. Borjeson-Forssman-Lehmann syndrome A syndrome that is characterized by growth delays, failure to thrive and malformations of the head and face that results in infantile death, has_material_basis_in homozygous mutation in the EMG1 gene on chromosome 12p13. GARD:5950 MESH:C537081 OMIM:211180 ORDO:1270 SNOMEDCT_US_2020_03_01:711153001 UMLS_CUI:C1859405 BWCNS Bowen Hutterite syndrome Bowen-Conradi Hutterite syndrome disease_ontology DOID:0050684 OMIM mapping confirmed by DO. [SN]. Bowen-Conradi syndrome A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells. snadendla 2011-06-13T01:25:14Z DOID:7137 NCI:C4099 SNOMEDCT_US_2020_03_01:5958006 UMLS_CUI:C0334239 Small cell carcinoma - intermediate cell Small cell carcinoma, intermediate cell intermediate cell small cell carcinoma disease_ontology DOID:0050685 small cell carcinoma A cancer that is classified based on the organ it starts in. snadendla 2011-06-13T03:28:33Z MESH:D009371 disease_ontology DOID:0050686 organ system cancer A cancer that is classified by the type of cell from which it is derived. snadendla 2011-06-13T03:28:50Z disease_ontology DOID:0050687 cell type cancer A large intestine cancer that is located_in the terminal part of the large intestine. snadendla 2011-06-14T01:34:36Z disease_ontology DOID:0050688 anal canal cancer A syndrome that is characterized by brachydactyly and syndactyly, has_material_basis_in heterozygous mutation in the HOXD13 gene on chromosome 2q31. snadendla 2011-06-17T03:55:47Z MESH:C565193 OMIM:610713 disease_ontology DOID:0050689 OMIM mapping confirmed by DO. [SN]. brachydactyly-syndactyly syndrome An osteochondrodysplasia characterized by generalized platyspondyly without significant long bone abnormalities and short stature. snadendla 2011-06-17T04:00:27Z GARD:10903 OMIM:113500 OMIM:271530 OMIM:271630 OMIM:613678 ORDO:1293 brachyrachia disease_ontology DOID:0050690 Xref MGI. OMIM mapping confirmed by DO. [SN]. brachyolmia A syndrome that is characterized by low birth weight and growth retardation, bilateral branchial clefts. snadendla 2011-06-17T04:10:18Z GARD:3212 OMIM:113620 disease_ontology DOID:0050691 OMIM mapping confirmed by DO. [SN]. branchiooculofacial syndrome A skin disease that is characterized by the development of several types of tumors from the skin, has_material_basis_in heterozygous mutation in the CYLD gene on chromosome 16q12. snadendla 2011-06-17T04:34:10Z GARD:10179 OMIM:605041 ORDO:79493 SNOMEDCT_US_2020_03_01:703531009 UMLS_CUI:C1857941 BRSS BSS CYLD cutaneous syndrome SBS Spiegler-Brooke Syndrome disease_ontology DOID:0050693 OMIM mapping confirmed by DO. [SN]. Brooke-Spiegler syndrome A syndrome that is characterized by sensorineural hearing loss and a variety of cranial nerve palsies, usually involving the motor components of the seventh and ninth to twelfth cranial nerves. snadendla 2011-06-17T04:38:07Z MESH:C537111 OMIM:PS211530 disease_ontology DOID:0050694 OMIM mapping confirmed by DO. [SN]. Brown-Vialetto-Van Laere syndrome MESH:C537111 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy. lschriml 2011-12-01T01:01:25Z disease_ontology DOID:0050696 fetal alcohol spectrum disorder A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection. lschriml 2012-01-03T01:13:08Z MESH:D002821 disease_ontology DOID:0050697 chorioamnionitis A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord. lschriml 2012-01-03T01:18:35Z disease_ontology DOID:0050698 funisitis A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. lschriml 2012-01-03T02:54:11Z ICD10CM:I42 ICD9CM:425 ICD9CM:425.9 MESH:D009202 NCI:C34830 NCI:C53654 SNOMEDCT_US_2020_03_01:266301006 SNOMEDCT_US_2020_03_01:89461002 SNOMEDCT_US_2020_03_01:89600009 UMLS_CUI:C0033141 UMLS_CUI:C0036529 UMLS_CUI:C0878544 Cardiomyopathies disease_ontology DOID:0050700 MESH:D009202 added from NeuroDevNet [WAK]. cardiomyopathy An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep. lschriml 2012-04-11T11:42:46Z electro-clinical syndrome disease_ontology DOID:0050701 electroclinical syndrome An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050702 JA:Epilepsy Genetics Kiel neonatal period electroclinical syndrome An electroclinical syndrome with onset in infancy occurring between birth and one year of age. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050703 JA:Epilepsy Genetics Kiel infancy electroclinical syndrome An electroclinical syndrome with onset in childhood between one and 12 years of age. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050704 JA:Epilepsy Genetics Kiel childhood electroclinical syndrome An electroclinical syndrome with onset in adolescence and adulthood. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050705 adolescence-adult electroclinical syndrome An electroclinial syndrome that is characterized by development of seizures later in life with a variable age of onset and duration. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050706 variable age at onset electroclinical syndrome A childhood electroclinical syndrome characterized by the occurrence of typical absence seizures starting between the age of four and ten years. lschriml 2012-04-11T02:29:04Z disease_ontology DOID:0050708 JA:Epilepsy Genetics Kiel early onset absence epilepsy A neonatal period electroclinical syndrome that is characterized by tonic spasms and partial seizures. lschriml 2012-05-10T10:02:58Z DOID:2481 GARD:9255 OMIM:PS308350 ORDO:1934 Early Infantile Epileptic Encephalopathy with Burst-Suppression disease_ontology DOID:0050709 early infantile epileptic encephalopathy An amino acid metabolic disorder that is classified by inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy. lschriml 2012-05-22T10:32:44Z GARD:10954 OMIM:PS210200 ORDO:6 3-Methylcrotonylglycinuria 3MCC deficiency BMCC deficiency disease_ontology DOID:0050710 3-Methylcrotonyl-CoA carboxylase deficiency An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus. lschriml 2012-05-22T11:47:25Z GARD:9499 OMIM:604290 disease_ontology DOID:0050711 aceruloplasminemia An amino acid metabolic disorder that has_material_basis_in a mutation in the GATM gene resulting in deficiency of arginine:glycine amidinotransferase which then limits creatine synthesis. lschriml 2012-05-22T11:53:57Z OMIM:612718 CEREBRAL CREATINE DEFICIENCY SYNDROME 3 arginine:glycine amidinotransferase deficiency disease_ontology DOID:0050712 AGAT deficiency An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism. lschriml 2012-06-11T02:44:53Z disease_ontology DOID:0050718 vitamin metabolic disorder An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood. lschriml 2012-06-13T03:09:31Z OMIM:238970 HHH syndrome Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome disease_ontology DOID:0050720 ornithine translocase deficiency An amino acid metabolic disorder that has_material_basis_in defects in the biosynthesis of the amino acid L-serine. lschriml 2012-06-13T03:09:31Z disease_ontology DOID:0050721 serine deficiency A tyrosinemia that has_material_basis_in deficiency of 4-hydroxyphenylpyruvate dioxygenase disrupting the break down of tyrosine. lschriml 2012-07-06T02:55:45Z OMIM:276710 disease_ontology DOID:0050727 tyrosinemia type III A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen. lschriml 2012-07-13T10:42:54Z disease_ontology DOID:0050728 glycogen metabolism disorder A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues. lschriml 2012-07-17T12:31:48Z OMIM:275630 Chanarin-Dorfman syndrome disease_ontology DOID:0050729 neutral lipid storage disease A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis. lschriml 2012-07-17T12:58:37Z GARD:10423 OMIM:PS607426 COENZYME Q10 DEFICIENCY, PRIMARY disease_ontology DOID:0050730 coenzyme Q10 deficiency disease A vitamin metabolic disorder that results from low blood levels of vitamin B12. lschriml 2012-07-17T01:01:29Z cobalamin deficiency hypocobalaminemia disease_ontology DOID:0050731 vitamin B12 deficiency A monogenic disease that has_material_basis_in muations in genes on the X chromosome. lschriml 2012-07-24T12:47:31Z disease_ontology DOID:0050735 X-linked monogenic disease An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease. lschriml 2012-07-24T12:51:47Z disease_ontology DOID:0050736 autosomal dominant disease An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop. lschriml 2012-07-24T12:51:47Z disease_ontology DOID:0050737 autosomal recessive disease A monogenic disease that has_material_basis_in a mutation in a single gene on one of the non-sex chromosomes. lschriml 2012-07-24T04:45:53Z disease_ontology DOID:0050739 autosomal genetic disease A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol. lschriml 2012-09-05T11:48:42Z EFO:0003829 KEGG:05034 OMIM:103780 SNOMEDCT_US_2020_03_01:66590003 alcoholism disease_ontology DOID:0050741 alcohol dependence A substance dependence that is characterized by a physical dependence on nicotine. lschriml 2012-09-05T11:48:42Z EFO:0003768 ICD10CM:F17 MESH:D014029 NCI:C54203 SNOMEDCT_US_2020_03_01:56294008 UMLS_CUI:C0028043 tobacco use disorder disease_ontology DOID:0050742 nicotine dependence A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells. lschriml 2012-09-18T01:56:52Z NK-T cell lymphoma mature T-cell and natural killer cell lymphoma disease_ontology DOID:0050743 mature T-cell and NK-cell lymphoma A non-Hodgkin lymphoma involving aberrant T-cells. lschriml 2012-09-18T01:57:40Z disease_ontology DOID:0050744 anaplastic large cell lymphoma A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body. lschriml 2012-09-18T01:58:25Z GARD:3178 disease_ontology DOID:0050745 diffuse large B-cell lymphoma A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. lschriml 2012-09-18T02:00:45Z GARD:6969 MESH:D020522 disease_ontology DOID:0050746 mantle cell lymphoma A B-cell lymphoma that is characterized by initial formation in the marginal zones of lymph tissue. lschriml 2012-09-18T02:00:45Z marginal zone lymphoma disease_ontology DOID:0050748 marginal zone B-cell lymphoma A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus. lschriml 2012-09-18T02:01:49Z GARD:7368 disease_ontology DOID:0050749 peripheral T-cell lymphoma A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp. lschriml 2012-09-18T02:03:06Z disease_ontology DOID:0050750 splenic marginal zone lymphoma A hereditary ataxia that is characterized by ataxia originating in the cerebellum. lschriml 2013-01-16T01:07:02Z MESH:D002524 disease_ontology DOID:0050753 cerebellar ataxia An autosomal recessive cerebellar ataxia that is characterized by the onset of ataxia between age three and thirty including axonal sensorimotor neuropathy, oculomotor apraxia, cerebellar atrophy and elevated alpha-fetoprotein, has_material_basis_in homozygous or compound heterozygous mutation in the SETX gene on chromosome 9q34. lschriml 2013-01-16T01:07:02Z OMIM:606002 disease_ontology DOID:0050755 ataxia with oculomotor apraxia type 2 A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems, and has_material_basis_in mutations in the TIMM8A gene resulting in abnormal protein transport within the mitochondria. lschriml 2013-01-16T01:20:50Z DOID:0050867 MESH:C535808 OMIM:304700 ORDO:3213 Deafness Dystonia Optic Atrophy Syndrome Deafness Dystonia Optic Neuronopathy Syndrome Dystonia Deafness Syndrome Jensen syndrome Mohr-Tranebjaerg Syndrome Mohr-Tranebjaerg syndrome deafness dystonia syndrome disease_ontology DOID:0050757 deafness-dystonia-optic neuronopathy syndrome An acquired metabolic disease that characterized by excessive production of acid. lschriml 2013-01-16T01:23:37Z disease_ontology DOID:0050758 metabolic acidosis A myotonic disease that is characterized by myotonia and progressive, proximal muscle wasting and weakness affecting the skeletal and smooth muscles of the neck, shoulders, elbows and hips and has_material_basis_in the autosomal dominant inheritance of the CNBP (ZNF9) gene containing an expansion of a CCTG repeat in intron one. lschriml 2013-01-16T01:27:31Z GARD:9728 ICD10CM:G71.1 ICD10CM:G71.19 ICD9CM:359.2 MESH:D020967 NCI:C122789 NCI:C122790 NCI:C84913 OMIM:602668 SNOMEDCT_US_2020_03_01:155096007 SNOMEDCT_US_2020_03_01:41574007 SNOMEDCT_US_2020_03_01:715788001 UMLS_CUI:C0221055 UMLS_CUI:C0553604 UMLS_CUI:C0752355 proximal myotonic myopathy disease_ontology DOID:0050759 myotonic dystrophy type 2 MESH:C535686 A syndrome that is characterized by congenital joint contractures, renal tubular dysfunction, cholestasis, severe failure to thrive, ichthyosis and a defect in platelet alpha-granule biogenesis and that has_material_basis_in homozygous or compound heterozygous mutation in the VPS33B gene or homozygous or compound heterozygous mutation in the VIPAR gene on chromosome 14q24.3. lschriml 2013-01-17T12:46:38Z OMIM:PS208085 ORDO:2697 ARTHROGRYPOSIS, RENAL DYSFUNCTION, AND CHOLESTASIS Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome Arthrogryposis-renal dysfunction-cholestasis disease_ontology DOID:0050763 ARC syndrome A neurodegenerative disease that is characterized by characterized by misshapen, spiny red blood cells (acanthocytosis) and neurological abnormalities, especially movement disorders. lschriml 2013-01-17T12:54:19Z GARD:10902 MESH:D054546 ORDO:263440 disease_ontology DOID:0050765 neuroacanthocytosis A neuroacanthocytosis characterized by progressive neurodegeneration and red cell acanthocytosis, with onset in the third to fifth decade of life and has_material_basis_in homozygous or compound heterozygous mutation in the VPS13A gene, which encodes chorein, on chromosome 9q21. lschriml 2013-01-17T12:54:19Z GARD:3956 MESH:D054546 NCI:C84926 OMIM:200150 ORDO:2388 SNOMEDCT_US_2020_03_01:26848004 UMLS_CUI:C0393576 Levine-Critchley syndrome choreo-acanthocytosis disease_ontology DOID:0050766 choreaacanthocytosis A syndrome that is characterized by intellectual disability, deafness, ocular abnormalities, T-cell leukemia, cryptorchidism, hypospadias and spasticity. lschriml 2013-02-21T11:32:26Z GARD:3902 OMIM:310465 ORDO:2608 NSX disease_ontology DOID:0050769 N syndrome A liver disease that is characterized by the presence of multiple cysts located_in the liver. lschriml 2013-02-21T11:36:13Z DOID:1173 GARD:9457 OMIM:174050 congenital cystic liver disease congenital hepatic cyst fibrocystic liver disease disease_ontology DOID:0050770 polycystic liver disease An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure. lschriml 2013-02-21T11:40:58Z GARD:7385 MESH:D010673 OMIM:171300 phaeochromocytoma disease_ontology DOID:0050771 pheochromocytoma A pheochromocytoma that arises in extraadrenal sympathetic ganglia. lschriml 2013-02-21T11:51:57Z MESH:D010235 NCI:C3308 OMIM:115310 OMIM:168000 OMIM:601650 OMIM:605373 OMIM:614165 OMIM:PS168000 SNOMEDCT_US_2020_03_01:302833002 UMLS_CUI:C0030421 chemodectoma glomus body tumor disease_ontology DOID:0050773 Xref MGI. paraganglioma A syndrome that is characterized by radial ray defect, patellae hypoplasia, cleft palate, diarrhea, dislocated joints, limb malformations, long nose and normal intelligence, has_material_basis_in homozygous or compound heterozygous mutation in the DNA helicase gene RECQL4 on chromosome 8q24. lschriml 2013-02-21T11:56:15Z GARD:4637 MESH:C535288 OMIM:266280 ORDO:3021 SNOMEDCT_US_2020_03_01:702413000 UMLS_CUI:C1849453 disease_ontology DOID:0050774 rapadilino syndrome An osteochondrodysplasia that is characterized by hypoplastic iliac bones, hypoplastic vertebral bodies, short ribs and broad long bones, prenatally lethal, has_material_basis_in homozygous or compound heterozygous mutation in the SLC35D1 gene on chromosome 1p31. lschriml 2013-02-21T12:00:39Z GARD:169 MESH:C536637 OMIM:269250 disease_ontology DOID:0050775 schneckenbecken dysplasia A non-syndromic intellectual disability characterized by a X-linked inheritance pattern. lschriml 2013-02-21T12:06:40Z OMIM:300716 OMIM:PS309530 ORDO:777 non-specific X-linked mental retardation disease_ontology DOID:0050776 Xref MGI. non-syndromic X-linked intellectual disability An amino acid metabolic disorder that is characterized by mental retardation, severe speech delay, behavioral abnormalities and seizures, has_material_basis_in mutation in the creatine transporter gene on chromosome Xq28. lschriml 2013-11-21T12:10:58Z disease_ontology DOID:0050798 cerebral creatine deficiency syndrome A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart. lschriml 2014-02-12T01:35:05Z ICD10CM:I44.3 ICD9CM:426.10 MESH:D054537 NCI:C26703 SNOMEDCT_US_2020_03_01:58547007 UMLS_CUI:C0004245 AV block disease_ontology DOID:0050820 atrioventricular block MESH:D054537 A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm. lschriml 2014-02-12T01:47:54Z SA node sinuatrial node disease_ontology DOID:0050824 sinoatrial node disease A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart. lschriml 2014-02-12T01:53:42Z disease_ontology DOID:0050825 endocardium disease A heart valve disease that is characterized by valvular insufficiency or valvular stenosis, located_in tricuspid valve between the right atrium and right ventricle. lschriml 2014-02-12T02:55:24Z DOID:13834 ICD10CM:I07 ICD9CM:397.0 SNOMEDCT_US_2020_03_01:49699002 UMLS_CUI:C0264776 RH. tricuspid valve disease Rheumatic disease of tricuspid valve Rheumatic tricuspid valve disease Tricuspid disease disease of tricuspid valve rheumatic tricuspid valve disease disease_ontology DOID:0050826 tricuspid valve disease A vascular disease that is located_in an artery. lschriml 2014-02-12T03:08:35Z disease_ontology DOID:0050828 artery disease A cardiovascular system disease that is located_in the fibrous sac surrounding the heart. lschriml 2014-02-18T12:20:15Z disease_ontology DOID:0050829 pericardium disease A dystonia that is localized to a specific part of the body. lschriml 2014-03-18T01:13:36Z GARD:6458 disease_ontology DOID:0050836 focal dystonia A focal dystonia that is characterized as dystonia that affects the muscles of the head, face, and neck. lschriml 2014-03-18T01:33:33Z disease_ontology DOID:0050845 cranio-facial dystonia A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep. lschriml 2014-03-20T03:57:22Z ICD10CM:G47.3 ICD9CM:780.57 MESH:D012891 NCI:C26884 SNOMEDCT_US_2020_03_01:206750008 UMLS_CUI:C0037315 disease_ontology DOID:0050847 sleep apnea A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. lschriml 2014-04-15T03:40:31Z disease_ontology DOID:0050851 glomerulosclerosis An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms. lschriml 2014-08-14T10:55:32Z disease_ontology DOID:0050888 syndromic intellectual disability An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms. lschriml 2014-08-14T10:57:36Z OMIM:613192 OMIM:614202 disease_ontology DOID:0050889 non-syndromic intellectual disability A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. lschriml 2014-08-14T03:29:17Z Synucleinopathies alpha Synucleinopathies disease_ontology DOID:0050890 synucleinopathy An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. lschriml 2014-10-06T14:36:37Z DOID:0060105 DOID:168 DOID:3858 DOID:4981 GARD:7005 MESH:D008527 MESH:D018242 NCI:C27294 NCI:C3222 NCI:C3716 OMIM:155255 SNOMEDCT_US_2020_03_01:189925001 SNOMEDCT_US_2020_03_01:443333004 UMLS_CUI:C0025149 UMLS_CUI:C0206663 UMLS_CUI:C1334410 CNS PNET CPNET brain medulloblastoma infratentorial primitive neuroectodermal tumor localized primitive neuroectodermal tumor disease_ontology DOID:0050902 OMIM mapping confirmed by DO. [SN]. medulloblastoma A salivary gland cancer that has_material_basis_in epithelial cells. lschriml 2014-10-08T16:52:58Z disease_ontology DOID:0050904 salivary gland carcinoma A breast carcinoma that derives_from breast lobules (milk glands). lschriml 2014-10-22T13:05:34Z disease_ontology DOID:0050938 breast lobular carcinoma A cerebellar ataxia that has_material_basis_in autosomal recessive inheritance. lschriml 2015-10-05T14:21:08Z OMIM:PS213200 ORDO:1172 disease_ontology DOID:0050950 autosomal recessive cerebellar ataxia A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. lschriml 2015-10-05T14:38:17Z GARD:6614 disease_ontology DOID:0050951 hereditary ataxia An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents. GARD:6337 disease_ontology DOID:0060000 infective endocarditis A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol. disease_ontology DOID:0060001 withdrawal disorder A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue. Quincke edema disease_ontology DOID:0060002 C1 inhibitor deficiency An autoimmune hypersensitivity disease located_in the central nervous system. disease_ontology DOID:0060004 autoimmune disease of central nervous system An autoimmune disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system. disease_ontology DOID:0060005 autoimmune disease of endocrine system A severe combined immunodeficiency that is characterized by recurrent bacterial, viral, and fungal infections, especially of the lung, and sterile necrotizing granulomas of the skin, develops_from deficiency or decreased surface expression of MHC Class I, has_material_basis_in autosomal recessive inheritance of mutation affecting MHC Class I production or expression and frequently involves TAP1 and TAP2 subunits, and is typically asymptomatic in infancy. OMIM:604571 BLS, TYPE I BLSI HLA CLASS I DEFICIENCY bare lymphocyte syndrome type I disease_ontology DOID:0060009 OMIM mapping confirmed by DO. [SN]. MHC class I deficiency A severe combined immunodeficiency that has_material_basis in the RAG1 and RAG2 genes on chromosome 11p and the Artemis gene on chromosome 10p. It is characterized by erythroderma, desquamation, alopecia, chronic diarrhea, failure to thrive, lymphadenopathy, and hepatosplenomegaly. GARD:8198 ICD10CM:D81.8 OMIM:603554 combined immunodeficiency with hypereosinophilia disease_ontology DOID:0060010 Omenn syndrome A severe combined immunodeficiency that is a X-linked SCID that has_material_basis_in mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells. DOID:5811 GARD:5618 MESH:D053632 NCI:C4682 OMIM:300400 SNOMEDCT_US_2020_03_01:203592006 UMLS_CUI:C1279481 SCID-X1 X-Linked Severe Combined Immunodeficiency XSCID gamma chain deficiency thymic epithelial hypoplasia disease_ontology DOID:0060013 OMIM mapping confirmed by DO. [LS]. X-linked severe combined immunodeficiency A severe combined immunodeficiency that is an actin regulator when mutated results in SCID through inhibition of thymic egress of mature thymocytes into peripheral lymphoid organs. OMIM:615401 disease_ontology DOID:0060019 coronin-1A deficiency A severe combined immunodeficiency that is the most severe form of SCID and has_material_basis_in mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions. DOID:1226 GARD:8625 MESH:C538361 NCI:C27070 OMIM:267500 SNOMEDCT_US_2020_03_01:111584000 UMLS_CUI:C0272167 De Vaal disease disease_ontology aleukocytosis DOID:0060020 OMIM mapping confirmed by DO. [SN]. reticular dysgenesis A combined T cell and B cell immunodeficiency that has_material_basis_in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay. OMIM:606593 LIG4 Syndrome disease_ontology DOID:0060021 OMIM mapping confirmed by DO. [SN]. DNA ligase IV deficiency A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE. OMIM:308230 HIGMX-1 X-linked hyper-IgM syndrome disease_ontology DOID:0060022 CD40 ligand deficiency A B cell deficiency that is an autosomal recessive disorder that has_material_basis_in mutation in the IgA (CD79 alpha) antigen receptor. GARD:10197 MESH:D017098 OMIM:137100 OMIM:269650 OMIM:609529 ORDO:69127 SNOMEDCT_US_2020_03_01:29260007 UMLS_CUI:C0162538 IgA deficiency gamma-A-globulin deficiency disease_ontology DOID:0060025 Xref MGI. immunoglobulin alpha deficiency A combined T cell and B cell immunodeficiency that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma. thymoma with hypogammaglobulinemia disease_ontology DOID:0060028 Good syndrome An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the exocrine system. disease_ontology DOID:0060029 autoimmune disease of exocrine system An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract. disease_ontology DOID:0060031 autoimmune disease of gastrointestinal tract An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system. disease_ontology DOID:0060032 autoimmune disease of musculoskeletal system An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system. disease_ontology DOID:0060033 autoimmune disease of peripheral nervous system A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause. disease_ontology DOID:0060036 intrinsic cardiomyopathy A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. disease_ontology DOID:0060037 developmental disorder of mental health A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination. disease_ontology DOID:0060038 specific developmental disorder An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue. disease_ontology DOID:0060039 autoimmune disease of skin and connective tissue A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors. DOID:1208 ICD9CM:299.80 UMLS_CUI:C0154451 pervasive development disorder disease_ontology DOID:0060040 pervasive developmental disorder A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior. GARD:10248 MESH:D000067877 disease_ontology DOID:0060041 autism spectrum disorder An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism. PDD disease_ontology DOID:0060042 atypical autism A disease of mental health that involves the impairment in normal sexual functioning. disease_ontology DOID:0060043 sexual disorder A sexual disorder that is characterized recurrent, intense sexually arousing fantasies, sexual urges or behaviors generally involving nonhuman objects. disease_ontology DOID:0060044 paraphilia disorder A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language. disease_ontology DOID:0060046 aphasia MESH:D001037 A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition. disease_ontology DOID:0060047 writing disorder An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract. disease_ontology DOID:0060049 autoimmune disease of urogenital tract An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood. disease_ontology DOID:0060050 autoimmune disease of blood An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system. disease_ontology DOID:0060051 autoimmune disease of cardiovascular system An immune system disease that has_material_basis_in abnormal immune responses. disease_ontology DOID:0060056 hypersensitivity reaction disease A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. DOID:1033 DOID:353 ICD10CM:C85.9 MESH:D008223 NCI:C3208 NCI:C7065 SNOMEDCT_US_2020_03_01:118600007 SNOMEDCT_US_2020_03_01:414628006 UMLS_CUI:C0024299 UMLS_CUI:C0598798 lymphoid cancer disease_ontology DOID:0060058 lymphoma A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma. MESH:D008228 OMIM:605027 ORDO:547 disease_ontology DOID:0060060 OMIM mapping confirmed by DO. [LS]. non-Hodgkin lymphoma A non-Hodgkin's lymphoma that has_material_basis_in a mutation of T cells. GARD:6226 MESH:D016410 cutaneous T-cell lymphoma disease_ontology DOID:0060061 cutaneous T cell lymphoma A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease. OMIM:162000 OMIM:613092 OMIM:614227 ORDO:209886 ORDO:217330 disease_ontology DOID:0060062 Xref MGI. OMIM mapping confirmed by DO. [LS]. familial juvenile hyperuricemic nephropathy A sideoblastic anemia that is characterized by the presence of microcytic hypochromic anemia and iron overload, and has_material_basis_in X-linked inheritance. OMIM:206000 disease_ontology DOID:0060066 OMIM mapping confirmed by DO. [LS]. pyridoxine-responsive sideroblastic anemia A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction. GARD:7343 OMIM:557000 Pearson Marrow-Pancreas Syndrome disease_ontology DOID:0060067 OMIM mapping confirmed by DO. [LS]. Pearson syndrome A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. lschriml 2011-05-11T12:18:41Z disease_ontology DOID:0060071 pre-malignant neoplasm A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. lschriml 2011-05-11T12:18:41Z disease_ontology DOID:0060072 benign neoplasm An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue. lschriml 2011-05-11T01:05:14Z disease_ontology DOID:0060073 lymphatic system cancer A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells. lschriml 2011-06-08T12:19:28Z disease_ontology DOID:0060074 ductal carcinoma in situ A breast cancer that is characterized by the presence of estrogen receptors. lschriml 2011-06-08T12:23:02Z disease_ontology DOID:0060075 estrogen-receptor positive breast cancer A thoracic benign neoplasm that is characterized by lack of malignancy. lschriml 2011-06-08T01:02:29Z disease_ontology DOID:0060082 breast benign neoplasm An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system. lschriml 2011-06-08T01:11:18Z disease_ontology DOID:0060083 immune system cancer A benign neoplasm that is classified by the type of cell or tissue from which it is derived. lschriml 2011-07-14T11:59:48Z disease_ontology DOID:0060084 cell type benign neoplasm A benign neoplasm that is classified by the organ system from which it is arising from. lschriml 2011-07-14T12:12:23Z disease_ontology DOID:0060085 organ system benign neoplasm A reproductive organ benign neoplasm that is characterized by a lack of malignancy located_in the female reproductive system. lschriml 2011-07-14T12:20:52Z disease_ontology DOID:0060086 female reproductive organ benign neoplasm A reproductive organ benign neoplasm that is characterized by a lack of malignancy located_in the male reproductive system. lschriml 2011-07-14T12:20:52Z disease_ontology DOID:0060087 male reproductive organ benign neoplasm An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. lschriml 2011-07-14T01:45:15Z disease_ontology DOID:0060089 endocrine organ benign neoplasm A nervous system benign neoplasm that is characterized by lack of malignancy. lschriml 2011-07-14T01:45:15Z disease_ontology DOID:0060090 central nervous system benign neoplasm An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system. lschriml 2011-07-14T01:45:15Z disease_ontology DOID:0060091 cardiovascular organ benign neoplasm A connective tissue benign neoplasm that is located_in bone. lschriml 2011-07-15T01:34:59Z disease_ontology DOID:0060094 bone benign neoplasm A female reproductive organ benign neoplasm that is located_in the uterus. lschriml 2011-07-15T01:42:11Z DOID:0060113 disease_ontology DOID:0060095 uterine benign neoplasm A nervous system benign neoplasm that is located_in a sensory organ. lschriml 2011-07-15T01:45:26Z disease_ontology DOID:0060096 sensory organ benign neoplasm An organ system benign neoplam that is located_in the thoracic cavity. lschriml 2011-07-15T01:55:57Z disease_ontology DOID:0060097 thoracic benign neoplasm A bone benign neoplasm of the bone that is characterized by clinical and histological similarity to osteoid osteomas. lschriml 2011-07-15T02:14:40Z MESH:D018215 disease_ontology DOID:0060098 osteoblastoma An organ system benign neoplasm that is located_in the muscular and skeletal organs. lschriml 2011-07-15T02:28:52Z disease_ontology DOID:0060099 musculoskeletal system benign neoplasm An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs. lschriml 2011-07-15T02:30:51Z DOID:0060124 skeletal system cancer disease_ontology DOID:0060100 musculoskeletal system cancer A cell type benign neoplasm that has_material_basis_in glial cells. lschriml 2011-07-19T01:27:04Z disease_ontology DOID:0060101 benign glioma A central nervous system cancer of children and young adults that develops from neural crest cells located_in cerebrum, has_material_basis_in abnormally proliferating cells derives_from neuroectoderm. lschriml 2011-07-21T02:24:10Z disease_ontology DOID:0060103 central nervous system primitive neuroectodermal neoplasm A brain cancer that has_material_basis_in glial cells. lschriml 2011-07-22T12:42:50Z lower grade glioma disease_ontology DOID:0060108 brain glioma A female reproductive organ benign neoplasm that is located_in the vulva. lschriml 2011-07-25T11:50:50Z disease_ontology DOID:0060109 vulvar benign neoplasm A female reproductive organ benign neoplasm that is located_in the ovary. lschriml 2011-07-25T11:50:50Z disease_ontology DOID:0060112 ovarian benign neoplasm An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system. lschriml 2011-07-25T12:47:43Z disease_ontology DOID:0060115 nervous system benign neoplasm A nervous system cancer that is located in the sensory system. lschriml 2011-07-25T01:51:56Z disease_ontology DOID:0060116 sensory system cancer A disease of anatomical entity that is located_in the thoracic cavity. lschriml 2011-07-25T02:23:47Z disease_ontology DOID:0060118 thoracic disease A gastrointestinal system cancer that is located_in the pharynx. lschriml 2011-07-27T01:26:34Z MESH:D010610 NCI:C3325 SNOMEDCT_US_2020_03_01:126685009 UMLS_CUI:C0031347 pharyngeal neoplasm pharynx neoplasm disease_ontology pharyngeal cancer DOID:0060119 pharynx cancer An organ system benign neoplasm located_in the integumentary system organs. lschriml 2011-07-27T01:49:44Z disease_ontology DOID:0060121 integumentary system benign neoplasm An organ system cancer that is located_in the skin, hair and nails. lschriml 2011-07-27T02:31:34Z disease_ontology DOID:0060122 integumentary system cancer A musculoskeletal system benign neoplasm that is located_in connective tissue. lschriml 2011-07-27T02:35:57Z DOID:177 MESH:D012983 NCI:C3377 SNOMEDCT_US_2020_03_01:126600002 UMLS_CUI:C0037579 neoplasm of soft tissue neoplasm of soft tissues soft tissue benign neoplasm tumor of the soft tissue disease_ontology DOID:0060123 connective tissue benign neoplasm A hypersensitivity reaction type IV disease that results from a proliferation of cells producing immunoglobulin heavy chains. lschriml 2011-08-22T11:23:09Z ICD10CM:C88.2 MESH:D006362 NCI:C3082 NCI:C3083 NCI:C3892 SNOMEDCT_US_2020_03_01:61493004 SNOMEDCT_US_2020_03_01:6381009 SNOMEDCT_US_2020_03_01:68979007 UMLS_CUI:C0018852 UMLS_CUI:C0018854 UMLS_CUI:C0242310 disease_ontology DOID:0060125 heavy chain disease MESH:D006362 A heavy chain disease that results from an overproduction of alpha antibodies (IgA). lschriml 2011-08-22T11:23:09Z Seligmann's disease disease_ontology DOID:0060126 alpha chain disease A heavy chain disease that results from an overproduction of gamma antibody (IgG). lschriml 2011-08-22T11:23:09Z GARD:10346 Franklin's disease disease_ontology DOID:0060127 gamma heavy chain disease A heavy chain disease that results from an overproduction of mu antibody (IgM). lschriml 2011-08-22T11:23:09Z disease_ontology DOID:0060128 mu chain disease An agnosia that is a deficiency in understanding, processing, or describing emotions. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060131 alexithymia An agnosia that is a loss of the ability to recognize musical notes, rhythms, and intervals. lschriml 2011-08-22T12:04:56Z receptive amusia disease_ontology DOID:0060132 amusia An agnosia that is a loss of the ability to gain feedback about one's own condition or impairments. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060133 anosognosia An agnosia that is a loss of the ability to distinguish visual shapes. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060134 apperceptive agnosia An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities. lschriml 2011-08-22T12:04:56Z GARD:5838 ICD10CM:R48.2 SNOMEDCT_US_2019_09_01:68345001 disease_ontology DOID:0060135 apraxia MESH:D001072 An agnosia that is a loss of the ability to recognize visual scenes or classes of objects but retain the abilty to describe them. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060136 associative agnosia An agnosia that is a loss of the ability to distinguishing environmental and non-verbal auditory cues including difficulty distinguishing speech from non-speech sounds even though hearing is usually normal. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060137 auditory agnosia An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060140 cortical deafness An agnosia that is a loss of the ability to distinguish the fingers on the hand. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060141 finger agnosia An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060142 form agnosia An agnosia that is a loss of the ability to perceive and process pain. lschriml 2011-08-22T12:04:56Z analgesia disease_ontology DOID:0060145 pain agnosia An agnosia that is a loss of the ability to recgonize a whole image or scene while retianing the ability to recognize objects or details in their visual field one at a time. lschriml 2011-08-22T12:04:56Z GARD:11943 disease_ontology DOID:0060148 simultanagnosia An agnosia that is the loss of the ability to recognize objects by touch based on its texture, size and weight. lschriml 2011-08-22T12:04:56Z somatosensory agnosia disease_ontology DOID:0060150 astereognosia An agnosia that is a loss of the ability to recognize or identify objects by touch alone. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060151 tactile agnosia An agnosia that is a loss of the ability to recognising spoken words as semantically meaningful. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060154 verbal auditory agnosia An agnosia that is a loss of the ability to visually recognize objects. lschriml 2011-08-22T12:04:56Z MESH:C531604 UMLS_CUI:C2930796 disease_ontology DOID:0060155 visual agnosia A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption. lschriml 2011-08-24T02:53:03Z disease_ontology DOID:0060158 acquired metabolic disease An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids. lschriml 2011-08-26T11:17:14Z GARD:9433 organic acid metabolism disorder organic aciduria disease_ontology DOID:0060159 organic acidemia A spinal muscular atrophy that is associated with the survival of motor neuron protein in childhood. lschriml 2011-08-29T01:15:14Z GARD:7674 MESH:D014897 NCI:C85076 ORDO:70 UMLS_CUI:C0700595 spinal muscular atrophies of childhood survival motor neuron spinal muscular atrophy disease_ontology DOID:0060160 childhood spinal muscular atrophy A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine) in exon 1 of AR gene encoding the androgen receptor. lschriml 2011-08-29T01:31:03Z GARD:6818 MESH:D055534 NCI:C85233 OMIM:313200 SNOMEDCT_US_2020_03_01:230253001 UMLS_CUI:C1839259 Kennedy disease SBMA Spinobulbar Muscular Atrophy X-Linked Bulbo-Spinal Atrophy X-linked Spinal and Bulbar Muscular Atrophy spinal bulbar muscular atrophy disease_ontology DOID:0060161 Kennedy's disease An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein. lschriml 2011-08-29T01:41:48Z GARD:5643 MESH:D020191 NCI:C122653 OMIM:125370 SNOMEDCT_US_2020_03_01:702422004 UMLS_CUI:C0751781 DRPLA Haw River Syndrome Naito-Oyanagi disease disease_ontology DOID:0060162 dentatorubral-pallidoluysian atrophy MESH:D020191 NCI:C122653 UMLS_CUI:C0751781 A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image). lschriml 2011-09-07T01:38:34Z body dysmorphia dysmorphic syndrome dysmorphophobia disease_ontology DOID:0060163 body dysmorphic disorder A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress. lschriml 2011-09-07T01:42:46Z disease_ontology DOID:0060164 pain disorder A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior. lschriml 2011-09-07T02:46:02Z MESH:D017593 OMIM:148840 disease_ontology DOID:0060165 Kleine-Levin syndrome A histidine metabolism disease characterized by a deficiency of the enzyme histidase. lschriml 2011-09-20T12:47:05Z GARD:6661 MESH:C538320 OMIM:235800 histidinuria disease_ontology DOID:0060168 histidinemia An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months. lschriml 2011-10-28T02:55:02Z GARD:1518 GARD:857 OMIM:601764 OMIM:605751 OMIM:607745 OMIM:612627 ORDO:306 BFIC BFIE benign familial infantile convulsion benign familial infantile seizures disease_ontology DOID:0060169 Xref MGI. benign familial infantile epilepsy An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures. lschriml 2011-11-08T10:42:18Z disease_ontology DOID:0060172 JA:Epilepsy Genetics Kiel juvenile absence epilepsy A syndrome that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form that has_material_basis_in mutations in a transcript variant of CACNA1C on chromosome 12p13.33. lschriml 2011-11-08T12:52:33Z DOID:0110649 ICD10CM:G72.3 MESH:C536962 OMIM:601005 ORDO:65283 ORDO:768 disease_ontology DOID:0060173 Timothy syndrome A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid. lschriml 2011-11-08T02:02:12Z MESH:C535803 OMIM:271980 4-hydroxybutyric aciduria SSADH gamma-hydroxybutyric aciduria disease_ontology DOID:0060175 succinic semialdehyde dehydrogenase deficiency An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway. lschriml 2011-11-08T02:02:12Z disease_ontology DOID:0060176 gamma-amino butyric acid metabolism disorder A gamma-amino butyric acid metabolism disorder that is characterized by an excess of homocarnosine in the brain and has_material_basis_in a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine. lschriml 2011-11-08T02:02:12Z GARD:2730 MESH:C535328 disease_ontology DOID:0060177 homocarnosinosis An inflammatory bowel disease that involves inflammation located_in colon. emitraka 2014-09-12T14:31:45Z EFO:0003872 ICD10CM:K52.9 MESH:D003092 NCI:C26723 SNOMEDCT_US_2020_03_01:64226004 UMLS_CUI:C0009319 disease_ontology DOID:0060180 colitis An urticaria induced by external physical influences. emitraka 2014-11-21T15:51:38Z disease_ontology DOID:0060220 WD correction. physical urticaria A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain. emitraka 2015-01-16T14:55:21Z ICD9CM:427.31 MESH:D001281 NCI:C50466 SNOMEDCT_US_2020_03_01:266306001 UMLS_CUI:C0004238 A-fib disease_ontology DOID:0060224 atrial fibrillation MESH:D001281 A gastrointestinal system disease that is located_in the gallbladder. emitraka 2015-02-02T15:48:08Z DOID:0000000 ICD10CM:K82.9 ICD9CM:575.9 MESH:D005705 NCI:C34631 OMIM:609918 OMIM:609919 OMIM:611465 SNOMEDCT_US_2020_03_01:155807008 UMLS_CUI:C0016977 disease_ontology DOID:0060262 Xref MGI. gallbladder disease A non-syndromic intellectual disability characterized by an autosomal dominant inheritance pattern. emitraka 2015-02-10T16:47:55Z GARD:12107 OMIM:PS156200 ORDO:178469 autosomal dominant mental retardation autosomal dominant non-syndromic mental retardation disease_ontology DOID:0060307 NT MGI. autosomal dominant non-syndromic intellectual disability A syndromic intellectual characterized by an X-linked inheritance pattern. emitraka 2015-02-11T16:14:46Z OMIM:PS309510 syndromic X-linked mental retardation disease_ontology DOID:0060309 NT MGI. syndromic X-linked intellectual disability A syndrome associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia. emitraka 2015-05-21T10:41:29Z disease_ontology DOID:0060340 ciliopathy A chromosomal disease that has_material_basis_in partial deletion of chromosomes. elvira 2015-09-28T15:48:41Z disease_ontology DOID:0060388 chromosomal deletion syndrome A chromosomal disease that has_material_basis_in extra copies of a chromosomal region. elvira 2015-10-02T15:19:23Z disease_ontology DOID:0060429 chromosomal duplication syndrome A corneal dystrophy that is characterized by abnormal deposition of proteins in the cornea and is caused by mutations in TGFBI gene of chromosome 5q. elvira 2015-10-16T16:39:25Z disease_ontology DOID:0060441 epithelial-stromal TGFBI dystrophy A corneal dystrophy that affects the corneal stroma. elvira 2015-10-16T16:39:25Z disease_ontology DOID:0060442 stromal dystrophy A corneal dystrophy that affects the corneal endothelium and/or the descemet membrane. elvira 2015-10-16T16:39:25Z endothelial dystrophy disease_ontology DOID:0060443 corneal endothelial dystrophy An allergic disease that is located_in the respiratory tract. airway allergy disease_ontology DOID:0060496 respiratory allergy An allergic disease that is located_in the gastrointestinal tract. disease_ontology DOID:0060502 gastrointestinal allergy A food allergy triggered by a plant fruit product. disease_ontology DOID:0060503 fruit allergy A bone disease that is located_in the spine. disease_ontology DOID:0060564 spinal disease A syndrome that is characterized by abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. GARD:9226 OMIM:PS605552 disease_ontology DOID:0060611 abdominal obesity-metabolic syndrome An ichthyosis that is characterized by autosomal recessive inheritance and abnormal skin scaling over the whole body due to a defect in keratinization. DOID:1699 ICD10CM:Q80.2 MESH:D017490 NCI:C84805 OMIM:PS242300 ORDO:281097 SNOMEDCT_US_2020_03_01:12215009 UMLS_CUI:C0079154 ARCI lamellar ichthyosis non bullous congenital ichthyosiform erythroderma disease_ontology DOID:0060655 autosomal recessive congenital ichthyosis A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp. GARD:5808 ICD10CM:Q00.0 OMIM:206500 ORDO:1048 disease_ontology DOID:0060668 anencephaly MESH:D000757 A leukodystrophy characterized by T2 hyperintensity and T1 iso- or hyperintensity of affected white matter in the central nervous system. OMIM:PS312080 HLD disease_ontology DOID:0060786 hypomyelinating leukodystrophy A syndrome that has_material_basis_in homozygous deletion on chromosome 2p21 that disrupts the SLC3A1 and PREPL genes. The deletion ranges in size from 23.8 to 75.5 kb. Itis characterized_by neonatal and infantile hypotonia and failure to thrive, cystinuria type 1 and nephrolithiasis, growth retardation due to growth hormone deficiency, and minor facial dysmorphism. ICD10CM:E72.0 OMIM:606407 ORDO:163690 cystinuria with mitochondrial disease disease_ontology DOID:0060858 hypotonia-cystinuria syndrome A primary bacterial infectious disease caused by the bacteria of the genus Salmonella. It has sypmtoms diarrhea, fever, vomiting, and abdominal cramps 12 to 72 hours after infection. In most cases, the illness lasts four to seven days, and most people recover without treatment. ICD10CM:A02.0 ICD9CM:003.0 Salmonella infection disease_ontology DOID:0060859 salmonellosis A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. MESH:D013927 disease_ontology DOID:0060903 thrombosis A fruit allergy triggered by Fabaceae (legume) plant fruit or seed food product. Fabaceae allergy disease_ontology DOID:0060904 legume allergy A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from precursor cells called blast cells. disease_ontology DOID:0070003 blastoma A bone marrow cancer that is formed of any one of the bone marrow cells belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages. myeloma disease_ontology DOID:0070004 myeloid neoplasm An electroclinical syndrome characterized by the occurrence of generalized onset seizures that cause lapses in awareness, begin and end abruptly, typically last only a few seconds and are associated with abnormal spike-wave discharges as seen by electroencephalogram. MESH:D004832 disease_ontology DOID:0070309 absence epilepsy A nutritional deficiency disease that is characterized by low levels of thiamine. NCI:C34418 SNOMEDCT_US_2020_03_01:399357009 disease_ontology DOID:0070313 thiamine deficiency disease A mitochondrial metabolism disease that is characterized by significant reduction in mitochondrial DNA in affected tissues, resulting in impaired mtDNA-encoded protein synthesis and energy production in the affected tissues and organs. GARD:13643 OMIM:PS603041 ORDO:35698 mtDNA depletion syndrome disease_ontology DOID:0070329 mitochondrial DNA depletion syndrome A musculoskeletal system disease that affects the muscles. disease_ontology DOID:0080000 muscular disease A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. DOID:1290 ICD10CM:M89.9 MESH:D001847 SNOMEDCT_US_2020_03_01:76069003 UMLS_CUI:C0005940 disease_ontology skeletal disease DOID:0080001 bone disease A bone disease that results_in formation or resorption abnormalities located_in bone. disease_ontology DOID:0080005 bone remodeling disease A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage. disease_ontology DOID:0080006 bone development disease A bone structure disease that results_in change or damage of structure located_in bone. disease_ontology DOID:0080007 bone deterioration disease A bone disease that results_in an interruption of blood supply located_in bone. disease_ontology DOID:0080008 ischemic bone disease A X-linked monogenic disease that has_material_basis_in dominant inheritance. disease_ontology DOID:0080009 X-linked dominant disease A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure. disease_ontology DOID:0080010 bone structure disease A bone remodeling disease that results in an abnormal decrease of bone density or mass. MESH:D001862 disease_ontology DOID:0080011 bone resorption disease A X-linked monogenic disease that has_material_basis_in recessive inheritance. disease_ontology DOID:0080012 X-linked recessive disease A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes. disease_ontology DOID:0080014 chromosomal disease A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment. congenital disorder disease_ontology DOID:0080015 physical disorder A neural tube defect that is characterized by incomplete closing of the spine and membranes around the spinal cord during early development. GARD:7673 ICD10CM:Q05 ICD9CM:741 MESH:D016135 NCI:C101214 SNOMEDCT_US_2020_03_01:156888006 UMLS_CUI:C0080178 disease_ontology DOID:0080016 spina bifida MESH:D016135 NCI:C101214 An osteochondrodysplasia that is characterized by abnormally broad ends of the arm and leg long bones resembling a boat oar or paddle due to enlargement of the spongy inner layer of bone. OMIM:215050 Bakwin-Krida syndrome Pyle's disease Pyle-Cohn syndrome disease_ontology DOID:0080019 metaphyseal dysplasia An osteochondrodysplasia that results_in abnormalities of bone growth located_in vertebral column, located_in epiphysis, located_in metaphysis. disease_ontology DOID:0080027 spondyloepimetaphyseal dysplasia A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue. GARD:6444 disease_ontology DOID:0080031 fibrous dysplasia An osteosclerosis that is characterized by hyperostosis and sclerosis of the craniofacial bones associated with abnormal modeling of the metaphyses. OMIM:PS123000 ORDO:1522 disease_ontology DOID:0080033 Xref MGI. craniometaphyseal dysplasia A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull. DOID:0080035 OMIM:239100 ORDO:3152 van Buchem disease disease_ontology DOID:0080036 SOST-related sclerosing bone dysplasia An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges. GARD:4611 MESH:D058631 OMIM:265800 ORDO:763 disease_ontology DOID:0080038 pycnodysostosis An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism. GARD:6724 ICD10CM:Q77.4 MESH:C562937 NCI:C118697 OMIM:146000 ORDO:429 SNOMEDCT_US_2020_03_01:205468002 UMLS_CUI:C0410529 disease_ontology DOID:0080041 hypochondroplasia An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period. GARD:2882 OMIM:PS200600 disease_ontology DOID:0080043 achondrogenesis An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face. GARD:6841 MESH:C537207 OMIM:156550 disease_ontology DOID:0080045 Kniest dysplasia A syndrome that is characterized by a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems. GARD:10782 OMIM:PS108300 ORDO:828 disease_ontology DOID:0080046 OMIM mapping confirmed by DO. [SN]. Stickler syndrome An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism. DOID:14800 GARD:4540 MESH:C535819 OMIM:177170 PSEUDOACHONDROPLASIA SPONDYLOEPIPHYSEAL DYSPLASIA, PSEUDOACHONDROPLASTIC pseudoachondroplastic dysplasia disease_ontology DOID:0080047 OMIM mapping confirmed by DO. [SN]. pseudoachondroplasia An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb dwarfism. GARD:6 ORDO:93437 disease_ontology DOID:0080049 acromesomelic dysplasia A colonic disease that is characterized by bowel obstruction resulting from impairment of the muscle contractions that move food through the digestive tract. lschriml 2015-10-19T14:28:30Z DOID:3878 GARD:12744 GARD:6789 MESH:D007418 NCI:C34733 ORDO:2978 SNOMEDCT_US_2020_03_01:715201005 UMLS_CUI:C0021847 Chronic intestinal pseudo-obstruction neuronal intestinal dysplasia disease_ontology DOID:0080072 intestinal pseudo-obstruction A physical disorder characterized by incomplete closure of the neural tube. lschriml 2015-10-19T14:41:42Z GARD:4016 OMIM:301410 OMIM:601634 disease_ontology DOID:0080074 neural tube defect A mitochondrial DNA depletion syndrome that is characterized by a clinical triad of psychomotor retardation, intractable epilepsy, and liver failure in infants and young children, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the nuclear gene encoding mitochondrial DNA polymerase gamma on chromosome 15q26. DOID:1442 GARD:5783 ICD10CM:G31.81 MESH:D002549 NCI:C35257 OMIM:203700 ORDO:726 SNOMEDCT_US_2020_03_01:20415001 UMLS_CUI:C0205710 Alper's syndrome Alpers disease Alpers progressive infantile poliodystrophy Alpers syndrome Alpers' disease or gray-matter degeneration Diffuse Cerebral Sclerosis of Schilder mitochondrial DNA depletion syndrome 4a progressive sclerosing poliodystrophy disease_ontology DOID:0080122 Alpers-Huttenlocher syndrome MESH:D002549 A mitochondrial DNA depletion syndrome that is characterized by progressive ataxia, hypotonia, hyporeflexia, athetosis and sensory impairment and has_material_basis_in autosomal recessive homozygous or compound heterozygous mutation in the C10ORF2 gene, which encodes the twinkle and twinky proteins, on chromosome 10q24. DOID:0050556 GARD:4062 MESH:C535523 OMIM:271245 OHAHA SYNDROME infantile onset spinocerebellar ataxia disease_ontology DOID:0080126 mitochondrial DNA depletion syndrome 7 A lipid storage disease characterized by lysosomal and lipase deficiency. OMIM:278000 disease_ontology DOID:0080217 lysosomal and lipase deficiency A central nervous system benign neoplasm the is located_in the peripheral nervous system. disease_ontology DOID:0080320 peripheral nervous system benign neoplasm A peripheral nervous system benign neoplasm that is located_in the autonomic nervous system. disease_ontology DOID:0080321 autonomic nervous system benign neoplasm A cystic kidney disease that is characterized by the growth of fluid-filled cysts in the kidneys that reduces kidney function and may lead to kidney failure. OMIM:PS173900 disease_ontology DOID:0080322 polycystic kidney disease A gastrointestinal system cancer that is located_in the hepatobiliary system. disease_ontology DOID:0080355 hepatobiliary system cancer A cell type cancer that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures, representing an early form of colorectal cancer. disease_ontology DOID:0080364 malignant adenoma A male reproductive system disease that is located_in the epididymis. disease_ontology DOID:0080373 epididymis disease A peroxisomal biogenesis disorder that has_material_basis_in defects in PEX genes. DOID:0080378 OMIM:PS214100 disease_ontology DOID:0080377 peroxisomal biogenesis disorder An early infantile epileptic encephalopathy that has_material_basis_in heterozygous mutation in the SCN1A gene on chromosome 2q24. DOID:0060171 GARD:10430 OMIM:607208 ORDO:33069 early infantile epileptic encephalopathy 6 disease_ontology DOID:0080422 Dravet syndrome A lipid storage disease that is characterized by increased storage of carbohydrates and lipids. disease_ontology DOID:0080488 mucolipidosis A thyroid gland carcinoma that derives_from epithelial cells of glandular origin. NCI:C27380 disease_ontology DOID:0080524 thyroid gland adenocarcinoma A thyroid gland adenocarcinoma characterized by extensive evidence of follicular cell differentiation. NCI:C7153 disease_ontology DOID:0080525 differentiated thyroid gland carcinoma A hyperimmunoglobin syndrome that is characterized by an immune system that fails to produce normal levels of the antibodies IgA, IgG and IgE but can produce normal or elevated levels of IgM. NCI:C3990 OMIM:PS308230 immunodeficiency with hyper-IgM disease_ontology DOID:0080544 hyper IgM syndrome A hyperimmunoglobulin syndrome that is characterized by eczema, distinct facial features, a tendency to experience bone fractures and recurrent bacterial infections of the skin and lungs. GARD:10956 OMIM:PS147060 hyper immunoglobulin E syndrome disease_ontology DOID:0080545 hyper IgE syndrome A viral infectious disease that has_material_basis_in Coronavirus. disease_ontology DOID:0080599 Coronavirus infectious disease A benign neoplasm that derives_from germ cells. disease_ontology DOID:0080601 germ cell benign neoplasm A germ cell benign neoplasm that derives_from mature tissue elements or a limited amount of immature tissue elements. NCI:C67107 disease_ontology DOID:0080602 benign teratoma A kidney benign neoplasm that is located_in the kidney cortex. benign nephroma disease_ontology DOID:0080615 nephroma A kidney disease that is located_in the kidney cortex. disease_ontology DOID:0080616 kidney cortex disease A sensory system benign neoplasm that is located in the auditory system. NCI:C8417 disease_ontology DOID:0080619 auditory system benign neoplasm A B-cell acute lymphoblastic leukemia that is characterized by the presence of too many B-cell lymphoblasts in the blood and bone marrow. DOID:7061 NCI:C8936 UMLS_CUI:C0862030 B-ALL precursor B lymphoblastic lymphoma/leukemia disease_ontology DOID:0080630 B-lymphoblastic leukemia/lymphoma An acute lymphocytic leukemia characterized by too many B-cell lymphoblasts (immature white blood cells) in the bone marrow and blood. NCI:C8644 B acute lymphoblastic leukemia B-cell acute lymphocytic leukemia disease_ontology DOID:0080638 B-cell acute lymphoblastic leukemia A bone cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. disease_ontology DOID:0080639 bone sarcoma A syndrome that has_material_basis_in mutations in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction. RAS/mitogen-activated protein kinase syndrome disease_ontology DOID:0080690 RASopathy An asthma that is characterized by severe and sudden onset of increasing wheezing, airways closing, smooth muscle contraction, mucus plugging and lower airway edema that may be reversible upon treatment. disease_ontology DOID:0080810 acute asthma A malignant glioma that originate from two types of glial cells, astrocytes and oligodendrocytes. NCI:C132067 disease_ontology DOID:0080829 low-grade glioma A low-grade glioma that occurs in children and encompasses tumors of astrocytic, oligodendroglial, and mixed glial-neuronal histology. disease_ontology DOID:0080830 pediatric low-grade glioma A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone. DOID:7455 ICD10CM:E23.0 OMIM:PS147950 ORDO:432 ORDO:478 congenital idiopathic hypogonadotropic hypogonadism hypogonadotropism isolated congenital gonadotropin deficiency disease_ontology DOID:0090070 hypogonadotropic hypogonadism A neuronal ceroid lipofuscinosis that is characterized by juvenile-onset of progressive dementia, seizures, and progressive visual failure and an ultrastructural pattern of lipopigment with a 'fingerprint' profile and has_material_basis_in homozygous or compound heterozygous mutation in the CLN3 gene on chromosome 16p11. DOID:0050756 GARD:5897 ICD10CM:E75.4 OMIM:204200 ORDO:228346 Batten disease CLN3 juvenile neuronal ceroid lipofuscinosis disease_ontology DOID:0110731 neuronal ceroid lipofuscinosis 3 A neurodegenerative disease characterized by progressive iron accumulation in the basal ganglia and other regions of the brain, resulting in extrapyramidal movements, such as parkinsonism and dystonia. GARD:11899 MESH:C538421 OMIM:PS234200 ORDO:385 UMLS_CUI:C2931845 NBIA disease_ontology DOID:0110734 neurodegeneration with brain iron accumulation A congenital muscular dystrophy-dystroglycanopathy type A characterized by cobblestone lissencephaly, muscle weakness, and brain and eye anomalies that has_material_basis_in autosomal recessive inheritance a defect in alpha-dystroglycan post-translational processing. OMIM:PS236670 ORDO:352687 MDDGA congenital muscular alpha-dystroglycanopathy with brain and eye anomalies klissencephaly type 2 with muscular and ocular involvement disease_ontology DOID:0111229 congenital muscular dystrophy-dystroglycanopathy type A A familial hyperlipidemia characterized by hypertriglyceridemia and fasting chylomicronemia. ORDO:444490 disease_ontology DOID:0111417 familial chylomicronemia syndrome A syndrome characterized by facial, limbs and genital anomalies, and a disproportionate acromelic short stature. ORDO:915 Aarskog-Scott syndrome faciodigitogenital syndrome faciogenital dysplasia disease_ontology DOID:0111824 Aarskog syndrome A syndrome characterized by sparse, brittle, sulfur-deficient hair that is easily broken and in more severe cases delayed development, significant intellectual disability, and recurrent infections. MESH:D054463 NCI:C4924 ORDO:33364 SNOMEDCT_US_2020_03_01:723551003 UMLS_CUI:C1955934 TTD disease_ontology DOID:0111866 trichothiodystrophy A trichothiodystrophy characterized by absence of extreme sensitivity to UV radiation. disease_ontology DOID:0111867 nonphotosensitive trichothiodystrophy A primary immunodeficiency disease that involves multiple components of the immune system. disease_ontology DOID:0111962 combined immunodeficiency An intestinal disease that involves intestinal infection that has_material_basis_in viruses, bacteria, fungi and parasites. DOID:10960 DOID:12509 DOID:5270 ICD10CM:A00-A09 ICD9CM:001-009.99 SNOMEDCT_US_2020_03_01:187266003 UMLS_CUI:C0178238 bacterial enteritis disease_ontology DOID:100 Updating outdated UMLS CUI. intestinal infectious disease DOID:11053 DOID:12112 DOID:12114 ICD9CM:389.1 MESH:D006319 NCI:C26739 SNOMEDCT_US_2020_03_01:60700002 UMLS_CUI:C0018784 High Frequency Hearing Loss High frequency deafness Perceptive deafness Perceptive hearing loss Perceptive hearing loss or deafness Sensorineural Deafness Sensory hearing loss central hearing loss high-frequency hearing loss disease_ontology DOID:10003 sensorineural hearing loss MESH:D006319 NCI:C5265 UMLS_CUI:C1336753 disease_ontology DOID:10011 thyroid lymphoma A multiple endocrine neoplasia that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas. GARD:3829 ICD10CM:E31.21 ICD9CM:258.01 MESH:D018761 NCI:C3225 OMIM:131100 ORDO:652 SNOMEDCT_US_2020_03_01:30664006 UMLS_CUI:C0025267 MEN type I Wermer syndrome Wermer's syndrome disease_ontology DOID:10017 OMIM mapping confirmed by DO. [SN]. multiple endocrine neoplasia type 1 An endometrial disease that is characterized by inflammation of the endometrium. MESH:D004716 NCI:C26764 SNOMEDCT_US_2020_03_01:155975003 UMLS_CUI:C0014179 disease_ontology DOID:1002 endometritis ICD10CM:C24.1 ICD9CM:156.2 NCI:C3536 SNOMEDCT_US_2020_03_01:93668007 UMLS_CUI:C0153454 malignant tumour of ampulla of vater disease_ontology DOID:10020 ampulla of Vater cancer A small intestine cancer that is located_in the beginning section of the small intestine. DOID:6072 ICD10CM:C17.0 ICD9CM:152.0 MESH:D004379 NCI:C4803 NCI:C9328 SNOMEDCT_US_2020_03_01:254570009 SNOMEDCT_US_2020_03_01:363403002 UMLS_CUI:C0153426 UMLS_CUI:C0541912 Duodenal cancer cancer of duodenum duodenal neoplasm disease_ontology DOID:10021 duodenum cancer A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon. DOID:10025 ICD10CM:G43.1 ICD9CM:346.0 MESH:D020325 NCI:C117005 OMIM:609179 OMIM:609670 SNOMEDCT_US_2020_03_01:155047002 UMLS_CUI:C0154723 classic migraine disease_ontology DOID:10024 Xref MGI. migraine with aura A tertiary neurosyphilis that results in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has symptom intense, stabbing pain in the back and legs that recurs irregularly, has symptom gait ataxia, has symptom hyperesthesia, has symptom paresthesia, has symptom loss of bladder sensation leading to urine retention, has symptom erectile dysfunction. GARD:8730 ICD10CM:A52.11 ICD9CM:094.0 MESH:D013606 NCI:C35057 SNOMEDCT_US_2020_03_01:266134000 UMLS_CUI:C0039223 Posterior spinal sclerosis Tabes dorsalis - neurosyphilis disease_ontology DOID:10027 tabes dorsalis A female reproductive system disease that is characterized by an infection of the female reproductive organs. ICD10CM:N73.9 ICD9CM:614.9 MESH:D000292 NCI:C3889 SNOMEDCT_US_2020_03_01:266648001 UMLS_CUI:C0242172 PID disease_ontology DOID:1003 pelvic inflammatory disease ICD10CM:H52.52 ICD9CM:367.51 SNOMEDCT_US_2020_03_01:68158006 UMLS_CUI:C0235238 Ciliary muscle paresis Cycloplegic paralysis of accommodation Paresis of accommodation disease_ontology DOID:10033 cycloplegia An eye disease that is characterized by decreased ability to change the optical power of the eye to maintain a clear image. ICD10CM:H52.5 ICD9CM:367.5 SNOMEDCT_US_2020_03_01:155137002 UMLS_CUI:C0152198 disease_ontology DOID:10034 eye accommodation disease MESH:D004416 UMLS_CUI:C0205747 FAMM syndrome familial atypical multiple mole-melanoma disease_ontology DOID:10041 OMIM mapping confirmed by DO. [SN]. dysplastic nevus syndrome A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule. GARD:9961 NCI:C4225 SNOMEDCT_US_2020_03_01:2142002 UMLS_CUI:C0334424 nodular melanoma disease_ontology DOID:10047 nodular malignant melanoma A uterine disease that is located_in the endometrium. NCI:C3504 SNOMEDCT_US_2020_03_01:418632009 UMLS_CUI:C0151622 disease_ontology DOID:1005 endometrial disease NCI:C4426 SNOMEDCT_US_2020_03_01:126696001 UMLS_CUI:C0345746 Subglottic tumor disease_ontology DOID:10069 subglottis neoplasm A parasitic helminthiasis infectious disease that involves infection of the bowel by Hymenolepis nana or Hymenolepis diminuta. The symptoms include diarrhea, gastrointestinal discomfort, itchy anus, poor appetite and weakness. GARD:2787 ICD10CM:B71.0 ICD9CM:123.6 MESH:D006925 NCI:C84768 SNOMEDCT_US_2020_03_01:187153007 UMLS_CUI:C0020413 Hymenolepis infectious disease dwarf tapeworm infection disease_ontology DOID:10074 hymenolepiasis A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia. GARD:942 ICD10CM:B70.0 ICD9CM:123.4 MESH:D004169 NCI:C128391 SNOMEDCT_US_2020_03_01:187151009 UMLS_CUI:C0012561 DiphylloboInOwlthrium infection fish tapeworm disease_ontology DOID:10075 diphyllobothriasis MESH:D004169 A taeniasis that results from ingestion of eggs or larvae of the Taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. Neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions. DOID:10078 DOID:14424 GARD:8194 ICD10CM:B69 ICD9CM:123.1 MESH:D003551 NCI:C34520 SNOMEDCT_US_2020_03_01:59051007 UMLS_CUI:C0010678 Pork tapeworm infection Tapeworm infection: intestinal taenia solum Tapeworm infection: pork intestinal taenia solium infection neurocysticercosis tenia solium infectious disease disease_ontology DOID:10079 cysticercosis A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected. ICD10CM:B70.1 ICD9CM:123.5 MESH:D013031 NCI:C35030 SNOMEDCT_US_2020_03_01:187152002 UMLS_CUI:C0037753 Infection by Sparganum Sparganosis disease_ontology DOID:10080 sparganosis MESH:D013031 A central nervous system disease that is located_in the skull and is characterized by a collection of pus (infected material) inside the skull. ICD9CM:324.0 NCI:C34734 SNOMEDCT_US_2020_03_01:192738001 UMLS_CUI:C0021874 disease_ontology DOID:10095 intracranial abscess A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances. ICD10CM:B56 ICD9CM:086.5 KEGG:05143 MESH:D014353 NCI:C84541 SNOMEDCT_US_2020_03_01:27031003 UMLS_CUI:C0041228 African sleeping sickness African trypanosomiasis disease_ontology DOID:10112 sleeping sickness A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans. ICD10CM:B57.2 ICD9CM:086 MESH:D014352 SNOMEDCT_US_2020_03_01:266205000 UMLS_CUI:C0041227 disease_ontology DOID:10113 trypanosomiasis A skin disease that is characterized by discoloration of the skin. ICD9CM:709.09 UMLS_CUI:C0375489 disease_ontology DOID:10123 pigmentation disease An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction. DOID:2284 ICD10CM:H18.9 ICD9CM:371.9 MESH:D003316 NCI:C26731 SNOMEDCT_US_2020_03_01:15250008 UMLS_CUI:C0010034 disease_ontology DOID:10124 corneal disease A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape. GARD:6824 ICD10CM:H18.6 ICD9CM:371.6 MESH:D007640 NCI:C26806 OMIM:148300 OMIM:608586 OMIM:608932 OMIM:609271 OMIM:614622 OMIM:614623 OMIM:614628 OMIM:614629 ORDO:156071 SNOMEDCT_US_2020_03_01:267733008 UMLS_CUI:C0022578 conical cornea disease_ontology DOID:10126 Xref MGI. keratoconus A vein disease that is characterized by impaired flow of blood through the veins. ICD9CM:459.81 MESH:D014689 NCI:C127822 SNOMEDCT_US_2020_03_01:20696009 UMLS_CUI:C0042485 peripheral venous insufficiency disease_ontology DOID:10128 venous insufficiency ICD9CM:302.79 UMLS_CUI:C0033951 disease_ontology DOID:10132 psychosexual disorder ICD10CM:E50.7 ICD9CM:375.15 MESH:D014985 NCI:C34503 SNOMEDCT_US_2020_03_01:193887002 UMLS_CUI:C0043349 Conjunctival xerosis disease_ontology DOID:10138 xerophthalmia ICD10CM:H11.10 ICD9CM:372.50 SNOMEDCT_US_2020_03_01:40787005 UMLS_CUI:C0155160 disease_ontology DOID:10139 conjunctival degeneration A lacrimal apparatus disease that is characterized by persistent irritation or burning of the coreneal surface. ICD10CM:H04.12 MESH:D015352 NCI:C34553 SNOMEDCT_US_2020_03_01:193980001 UMLS_CUI:C0013238 Tear film insufficiency dry eye disease disease_ontology DOID:10140 dry eye syndrome MESH:D015352 An intestinal cancer that is located_in the small intestine. GARD:9385 ICD10CM:C17 ICD9CM:152.9 NCI:C7523 SNOMEDCT_US_2020_03_01:363509000 UMLS_CUI:C0153425 disease_ontology DOID:10154 small intestine cancer A gastrointestinal system cancer that is located_in the intestine. ICD10CM:C26.0 ICD9CM:159.0 MESH:D007414 NCI:C4572 SNOMEDCT_US_2020_03_01:93838000 UMLS_CUI:C0346627 malignant intestinal tumors malignant neoplasm of intestine disease_ontology DOID:10155 intestinal cancer An ischemic bone disease that results_in necrosis located_in bone. DOID:10160 DOID:10161 DOID:10162 DOID:10163 DOID:10164 DOID:4128 DOID:8380 DOID:86 ICD10CM:M87 ICD10CM:M87.9 ICD9CM:732.3 ICD9CM:733.41 ICD9CM:733.42 ICD9CM:733.43 ICD9CM:733.44 MESH:D010020 NCI:C34404 NCI:C34841 NCI:C34880 NCI:C35226 NCI:C35517 SNOMEDCT_US_2020_03_01:156837008 SNOMEDCT_US_2020_03_01:17926002 SNOMEDCT_US_2020_03_01:240196003 SNOMEDCT_US_2020_03_01:29281007 SNOMEDCT_US_2020_03_01:43453000 SNOMEDCT_US_2020_03_01:62100001 SNOMEDCT_US_2020_03_01:83453001 UMLS_CUI:C0003977 UMLS_CUI:C0027543 UMLS_CUI:C0029445 UMLS_CUI:C0158442 UMLS_CUI:C0158449 UMLS_CUI:C0158450 UMLS_CUI:C0158451 UMLS_CUI:C0745048 Avascular necrosis of bone aseptic necrosis bone necrosis disease_ontology DOID:10159 osteonecrosis A skin benign neoplasm that derives_from fat cells. DOID:10198 DOID:3943 ICD9CM:214.0 NCI:C4616 NCI:C5566 SNOMEDCT_US_2020_03_01:255187008 SNOMEDCT_US_2020_03_01:93159009 UMLS_CUI:C0153968 UMLS_CUI:C0347394 UMLS_CUI:C1333174 Cutaneous Lipoma Lipoma of skin cutaneous lipomatous tumor lipoma of face disease_ontology DOID:10188 skin lipoma A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow. DOID:1018 DOID:1020 DOID:10281 DOID:10282 DOID:10692 DOID:10860 DOID:1164 DOID:11788 DOID:11959 DOID:12011 DOID:13673 DOID:13674 DOID:13675 DOID:13678 DOID:13684 DOID:13737 DOID:14003 DOID:14100 DOID:14166 DOID:2249 DOID:2250 DOID:5858 DOID:9456 GARD:7286 ICD9CM:730.1 SNOMEDCT_US_2020_03_01:203181001 UMLS_CUI:C0008707 disease_ontology DOID:1019 osteomyelitis A breast benign neoplasm that is composed of lipocytes. NCI:C4647 SNOMEDCT_US_2020_03_01:276891009 UMLS_CUI:C0349565 Lipoma of breast disease_ontology DOID:10199 breast lipoma EFO:0004799 ICD9CM:574.5 SNOMEDCT_US_2020_03_01:197397004 UMLS_CUI:C0006739 disease_ontology DOID:10211 cholelithiasis A myositis that results_in inflammation located_in muscle or located_in skin where a skin rash is often seen prior to the onset of muscle weakness. The disease may result from either a viral infection or an autoimmune reaction. GARD:6263 ICD10CM:M33 ICD9CM:710.3 MESH:D003882 NCI:C26744 SNOMEDCT_US_2020_03_01:38826005 UMLS_CUI:C0011633 Polymyositis with skin involvement dermatopolymyositis disease_ontology Amyopathic dermatomyositis Amyopathic dermatomyositis DOID:10223 MESH:C538250 added from NeuroDevNet [WAK]. dermatomyositis ICD10CM:I70.0 ICD9CM:440.0 SNOMEDCT_US_2020_03_01:81817003 UMLS_CUI:C0155733 Aortic atherosclerosis Atherosclerosis of aorta disease_ontology DOID:10230 aortic atherosclerosis ICD10CM:F65.2 ICD9CM:302.4 MESH:D005084 NCI:C94352 SNOMEDCT_US_2020_03_01:192514003 UMLS_CUI:C0015269 disease_ontology DOID:10236 exhibitionism A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage. EFO:0001054 GARD:6886 ICD10CM:A30 ICD9CM:030 MESH:D007918 NCI:C84824 OMIM:607572 OMIM:609888 OMIM:613407 ORDO:548 SNOMEDCT_US_2020_03_01:154298007 UMLS_CUI:C0023343 disease_ontology DOID:1024 Xref MGI. leprosy A hemolytic anemia characterized by decreased synthesis of one or more hemoglobin polypeptide chains. DOID:12242 DOID:12243 GARD:7756 ICD10CM:D56 ICD9CM:282.4 MESH:D013789 NCI:C35069 SNOMEDCT_US_2020_03_01:191192008 UMLS_CUI:C0039730 Sickle-cell thalassemia with crisis Sickle-cell thalassemia without crisis thalassemia Hb-S disease with crisis thalassemia Hb-S disease without crisis disease_ontology DOID:10241 OMIM mapping confirmed by DO. [LS]. thalassemia A primary bacterial infectious disease that results in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash. DOID:0050023 GARD:2092 ICD10CM:A77.4 ICD9CM:082.4 MESH:D016873 SNOMEDCT_US_2020_03_01:77361002 UMLS_CUI:C0085399 human ehrlichiosis disease_ontology DOID:10242 ehrlichiosis MESH:D016873 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. ICD9CM:511.8 UMLS_CUI:C0029799 disease_ontology DOID:10247 pleurisy A viral infectious disease that results in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted by sheep tick, Ixodes ricinus. The infection has symptom lethargy, has symptom muscle pains, has symptom fever, and has symptom focal neurological signs. ICD10CM:A84.8 ICD9CM:063.1 MESH:D008146 SNOMEDCT_US_2020_03_01:59350003 UMLS_CUI:C0024025 Louping ill disease_ontology DOID:10250 louping ill A viral infectious disease that results in inflammation located in salivary gland, has_material_basis_in Mumps rubulavirus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. The infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face. GARD:7116 ICD10CM:B26 ICD9CM:072 MESH:D009107 NCI:C29888 SNOMEDCT_US_2020_03_01:154352008 UMLS_CUI:C0026780 disease_ontology DOID:10264 mumps A cardiovascular system disease that involves the heart's electrical conduction system. ICD9CM:426.6 SNOMEDCT_US_2020_03_01:195053008 UMLS_CUI:C0029630 heart rhythm disease disease_ontology DOID:10273 heart conduction disease A male reproductive organ cancer that is located_in the prostate. DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 SNOMEDCT_US_2020_03_01:126906006 SNOMEDCT_US_2020_03_01:93974005 UMLS_CUI:C0033578 UMLS_CUI:C0376358 NGP - new growth of prostate hereditary prostate cancer malignant tumor of the prostate prostate cancer, familial prostate neoplasm prostatic cancer prostatic neoplasm tumor of the prostate disease_ontology DOID:10283 Xref MGI. OMIM mapping confirmed by DO. [SN]. prostate cancer GARD:6422 ICD10CM:G72.3 MESH:D010245 NCI:C84709 SNOMEDCT_US_2020_03_01:193241004 UMLS_CUI:C0030443 disease_ontology DOID:1029 familial periodic paralysis ICD10CM:I73.0 MESH:D011928 OMIM:179600 SNOMEDCT_US_2020_03_01:195295006 UMLS_CUI:C0034734 Raynaud's disease Raynaud's syndrome disease_ontology DOID:10300 OMIM mapping confirmed by DO. [SN]. Raynaud disease MESH:D011928 A parotid disease characterized by the inflammation of one or both parotid glands. ICD10CM:K11.2 MESH:D010309 NCI:C114281 SNOMEDCT_US_2020_03_01:196481002 UMLS_CUI:C0030583 disease_ontology DOID:10301 parotitis MESH:D010309 MESH:D010305 UMLS_CUI:C0030579 disease_ontology DOID:10302 parotid disease GARD:7638 ICD10CM:K11.2 ICD9CM:527.2 MESH:D012793 NCI:C26882 SNOMEDCT_US_2020_03_01:42982001 UMLS_CUI:C0037023 Sialoadenitis disease_ontology DOID:10303 sialadenitis A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves. DOID:14058 ICD10CM:I33.9 ICD9CM:421.9 MESH:D004696 NCI:C34582 NCI:C35432 SNOMEDCT_US_2020_03_01:56819008 SNOMEDCT_US_2020_03_01:91357005 UMLS_CUI:C0014118 UMLS_CUI:C0375268 disease_ontology DOID:10314 endocarditis An interstitial lung disease that is caused by the inhalation of dust. ICD10CM:J64 ICD9CM:505 MESH:D011009 NCI:C26861 SNOMEDCT_US_2020_03_01:196004000 UMLS_CUI:C0032273 disease_ontology DOID:10316 pneumoconiosis A pneumoconiosis caused by inhalation and retention of asbestos fibers. GARD:5852 ICD10CM:J61 ICD9CM:501 MESH:D001195 NCI:C84573 SNOMEDCT_US_2020_03_01:266400008 UMLS_CUI:C0003949 disease_ontology DOID:10320 asbestosis GARD:5976 ICD10CM:J66.0 MESH:D002095 NCI:C84605 SNOMEDCT_US_2020_03_01:155589004 UMLS_CUI:C0006542 Flax-dressers' disease Stripper's asthma cotton mill fever disease_ontology DOID:10323 byssinosis A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles. DOID:14007 GARD:7647 ICD10CM:J62.8 ICD9CM:502 MESH:D012829 NCI:C3369 SNOMEDCT_US_2020_03_01:155590008 UMLS_CUI:C0037116 Pneumoconiosis due to silicates Silica pneumoconiosis Silicotic fibrosis of lung silicotuberculosis disease_ontology DOID:10325 silicosis ICD10CM:J60 ICD9CM:500 MESH:D055008 NCI:C34390 SNOMEDCT_US_2020_03_01:29422001 UMLS_CUI:C0003165 Coal Miner's Pneumoconiosis Coal workers' lung Coal workers' pneumoconiosis Melanoedema black lung disease_ontology DOID:10327 anthracosis GARD:7645 ICD10CM:J63.4 MESH:D012806 SNOMEDCT_US_2020_03_01:155591007 UMLS_CUI:C0037061 pulmonary siderosis disease_ontology DOID:10328 siderosis GARD:5932 ICD10CM:H02.52 ICD9CM:374.46 MESH:D016569 UMLS_CUI:C0005744 disease_ontology DOID:10348 blepharophimosis MESH:D016569 A breast benign neoplasm that is characterized by a fluid-filled sac. ICD10CM:N60.0 MESH:D047688 NCI:C5315 SNOMEDCT_US_2020_03_01:56726003 UMLS_CUI:C0006144 Cyst of the breast disease_ontology DOID:10350 breast cyst A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. DOID:10747 ICD10CM:C91 ICD9CM:204 MESH:D007945 NCI:C7539 SNOMEDCT_US_2020_03_01:93170002 UMLS_CUI:C0023448 lymphoblastic leukaemia lymphoblastic leukemia lymphocytic leukaemia lymphoid leukemia disease_ontology DOID:1037 lymphoid leukemia A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. The infection has symptom skin lesions. GARD:7913 ICD10CM:A66 ICD9CM:102 MESH:D015001 NCI:C41353 SNOMEDCT_US_2020_03_01:266213004 UMLS_CUI:C0043388 Bouba frambesia frambesia tropica frambosie polypapilloma tropicum thymosis disease_ontology DOID:10371 yaws ICD10CM:H53.03 ICD9CM:368.01 MESH:D000550 SNOMEDCT_US_2020_03_01:35600002 UMLS_CUI:C0750903 Strabismic amblyopia disease_ontology DOID:10375 suppression amblyopia An eye disease that is characterized by poor vision in one eye resulting from the brain failing to process inputs from one eye and over time favors the other eye. ICD10CM:H53.00 ICD9CM:368.00 MESH:D000550 NCI:C118764 SNOMEDCT_US_2020_03_01:155145007 UMLS_CUI:C0002418 disease_ontology DOID:10376 amblyopia MESH:D000550 ICD10CM:H53.01 ICD9CM:368.02 SNOMEDCT_US_2020_03_01:193638002 UMLS_CUI:C0152189 Deprivation amblyopia disease_ontology DOID:10378 disuse amblyopia MESH:D015463 NCI:C3181 SNOMEDCT_US_2020_03_01:110006004 UMLS_CUI:C0023486 disease_ontology DOID:1039 prolymphocytic leukemia ICD10CM:M89.4 ICD9CM:731.2 MESH:D010005 SNOMEDCT_US_2020_03_01:46922002 UMLS_CUI:C0029412 Bamberger-Marie disease HPOA - hypertrophic pulmonary osteoarthropathy Marie Bamberger disease hypertrophic pulmonary osteoarthropathy disease_ontology DOID:10393 secondary hypertrophic osteoarthropathy A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing. DOID:10401 DOID:10402 ICD10CM:A20.2 ICD9CM:020.3 ICD9CM:020.4 ICD9CM:020.5 MESH:D010930 SNOMEDCT_US_2020_03_01:35339003 SNOMEDCT_US_2020_03_01:38976008 SNOMEDCT_US_2020_03_01:67525007 UMLS_CUI:C0152937 UMLS_CUI:C0152938 UMLS_CUI:C0524688 primary pneumonic plague secondary pneumonic plague disease_ontology DOID:10398 pneumonic plague A disease by infectious agent that results_in infection, has_material_basis_in Bacteria. ICD10CM:A49.9 MESH:D001424 NCI:C2890 SNOMEDCT_US_2020_03_01:87628006 UMLS_CUI:C0004623 disease_ontology DOID:104 bacterial infectious disease A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. EFO:0000095 GARD:6104 ICD10CM:C91.10 ICD9CM:204.1 MESH:D015451 NCI:C3163 OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559 ORDO:67038 SNOMEDCT_US_2020_03_01:51092000 UMLS_CUI:C0023434 B-cell chronic lymphocytic leukaemia B-cell chronic lymphocytic leukemia CLL chronic lymphatic leukaemia chronic lymphatic leukemia chronic lymphocytic leukaemia lymphoplasmacytic leukaemia lymphoplasmacytic leukemia disease_ontology B-cell chronic lymphoid leukemia DOID:1040 Xref MGI. chronic lymphocytic leukemia A physical disorder that is characterized by abnormal segmentation of the vertebra during fetal development which results in fusion located in cervical vertebra. DOID:14747 GARD:10280 ICD10CM:Q76.1 ICD9CM:756.16 MESH:D007714 NCI:C98967 OMIM:PS118100 ORDO:2345 SNOMEDCT_US_2020_03_01:268349005 UMLS_CUI:C0022738 Klippel-Feil and Turner syndrome Klippel-Feil deformity, deafness and facial asymmetry autosomal dominant Klippel-Feil syndrome congenital dystrophia brevicollis congenital synostosis of cervical vertebrae disease_ontology DOID:10426 Xref MGI. OMIM mapping confirmed by DO. [SN]. Klippel-Feil syndrome A corneal ulcer that is characterized by painful peripheral corneal ulceration, sterile limbal inflammation, and episcleral and conjunctival edema. ICD10CM:H16.05 ICD9CM:370.07 SNOMEDCT_US_2020_03_01:22440001 UMLS_CUI:C0155072 Mooren ulcer disease_ontology DOID:10439 Mooren's ulcer An upper respiratory tract disease which is characterized by inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat, painful or difficult swallowing, coughing, headache, myalgia, fever and chills. DOID:10454 DOID:13751 ICD10CM:J35.01 ICD9CM:474.00 MESH:D014069 NCI:C116006 SNOMEDCT_US_2020_03_01:195665006 SNOMEDCT_US_2020_03_01:195794009 UMLS_CUI:C0040425 UMLS_CUI:C0149517 Throat infection - tonsillitis chronic tonsillitis disease_ontology DOID:10456 tonsillitis A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough. ICD10CM:A48.1 ICD9CM:482.84 MESH:D007877 NCI:C128339 SNOMEDCT_US_2020_03_01:195889001 UMLS_CUI:C0023241 Infection by Legionella pneumophilia Legionella Legionella pneumonia Legionnaire's disease disease_ontology DOID:10457 Legionnaires' disease A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea. MESH:D007876 NCI:C128334 SNOMEDCT_US_2020_03_01:26726000 UMLS_CUI:C0023240 Legionella infection disease_ontology DOID:10458 legionellosis An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus. ICD10CM:J00 ICD9CM:460 MESH:D003139 NCI:C34500 SNOMEDCT_US_2020_03_01:195648002 UMLS_CUI:C0009443 Acute viral rhinopharyngitis Nasopharyngitis - acute Nasopharyngitis, acute acute Nasopharyngitis acute coryza acute nasopharyngitis acute rhinitis rhino-sinusitis disease_ontology DOID:10459 common cold A nasopharyngeal disease which involves inflammation of the nasal passages and upper part of the pharynx. DOID:11587 ICD10CM:J00 ICD10CM:J31.1 ICD9CM:472.2 MESH:D009304 NCI:C34837 SNOMEDCT_US_2020_03_01:155524006 SNOMEDCT_US_2020_03_01:51476001 UMLS_CUI:C0027441 UMLS_CUI:C0155826 chronic nasopharyngitis disease_ontology DOID:10460 nasopharyngitis ICD10CM:K02 ICD9CM:521.02 SNOMEDCT_US_2020_03_01:442551007 UMLS_CUI:C0266846 Compound dental caries Dental caries extending into dentine Dentin caries disease_ontology DOID:10461 dentin caries ICD10CM:M76.5 ICD9CM:726.64 SNOMEDCT_US_2020_03_01:156662006 UMLS_CUI:C0158317 Patellar tendonitis disease_ontology DOID:10471 patellar tendinitis ICD10CM:Q79.1 MESH:D003965 NCI:C98912 SNOMEDCT_US_2020_03_01:34168003 UMLS_CUI:C0011981 disease_ontology DOID:10480 diaphragmatic eventration A muscular disease that is located_in the diaphragm. ICD10CM:J98.6 ICD9CM:519.4 SNOMEDCT_US_2020_03_01:48475001 UMLS_CUI:C0152097 disease_ontology DOID:10481 diaphragm disease GARD:6381 ICD10CM:Q39.0 MESH:D004933 NCI:C87072 SNOMEDCT_US_2020_03_01:156947007 UMLS_CUI:C0014850 Congenital atresia of esophagus Congenital imperforate esophagus Imperforate esophagus Oesophageal atresia disease_ontology DOID:10485 esophageal atresia ICD10CM:Q41.1 MESH:D007409 NCI:C84790 UMLS_CUI:C0021828 disease_ontology DOID:10486 intestinal atresia A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel. GARD:6660 ICD10CM:Q43.1 MESH:D006627 NCI:C34700 OMIM:600156 OMIM:606874 OMIM:606875 OMIM:608462 OMIM:611644 ORDO:388 SNOMEDCT_US_2020_03_01:204739008 UMLS_CUI:C0019569 Hirschsprung disease aganglionic megacolon congenital megacolon macrocolon pelvirectal achalasia total intestinal aganglionosis disease_ontology DOID:10487 Xref MGI. OMIM mapping confirmed by DO. [SN]. Hirschsprung's disease GARD:6769 ICD10CM:Q42.3 MESH:D001006 NCI:C84784 OMIM:207500 OMIM:301800 SNOMEDCT_US_2020_03_01:156956004 UMLS_CUI:C0003466 Congenital atresia of anus Congenital or infantile occlusion of anus Imperforate anus anal atresia disease_ontology DOID:10488 OMIM mapping confirmed by DO. [SN]. imperforate anus ICD9CM:255.4 NCI:C26691 SNOMEDCT_US_2020_03_01:68588005 UMLS_CUI:C0405580 Adrenal Cortical Insufficiency Corticoadrenal insufficiency disease_ontology DOID:10493 adrenal cortical hypofunction A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus. DOID:13167 ICD10CM:J12.9 ICD9CM:480 MESH:D011024 SNOMEDCT_US_2020_03_01:195880002 UMLS_CUI:C0032310 disease_ontology DOID:10533 viral pneumonia A gastrointestinal system cancer that is located_in the stomach. DOID:10539 DOID:10542 DOID:10543 DOID:4713 GARD:7704 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 SNOMEDCT_US_2020_03_01:126824007 SNOMEDCT_US_2020_03_01:269459004 SNOMEDCT_US_2020_03_01:269460009 SNOMEDCT_US_2020_03_01:93717002 SNOMEDCT_US_2020_03_01:94074003 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423 gastric cancer gastric neoplasm disease_ontology DOID:10534 OMIM mapping confirmed by DO. [SN]. stomach cancer GARD:6485 NCI:C4636 SNOMEDCT_US_2020_03_01:276811008 UMLS_CUI:C0349532 Lymphoma of the stomach disease_ontology DOID:10540 gastric lymphoma ICD10CM:C16.0 ICD9CM:151.0 SNOMEDCT_US_2020_03_01:93738008 UMLS_CUI:C0153417 Ca cardia - stomach malignant neoplasm of cardia of stomach disease_ontology DOID:10548 cardia cancer A central nervous system disease that involves encephalitis which occurs along with meningitis. ICD10CM:A69.22 MESH:D008590 NCI:C34813 SNOMEDCT_US_2020_03_01:7125002 UMLS_CUI:C0025309 Meningoencephalitis disease_ontology DOID:10554 meningoencephalitis A syndrome that has_material_basis_in mutation in the OCRL gene on chromosome Xq26 and that is characterized by hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, amino aciduria, and reduced ammonia production by the kidney. GARD:3295 ICD10CM:E72.03 MEDDRA:10051707 MESH:D009800 NCI:C84940 OMIM:309000 ORDO:534 SNOMEDCT_US_2020_03_01:79385002 UMLS_CUI:C0028860 Lowe syndrome lowe oculocerebrorenal syndrome oculocerebrorenal syndrome of Lowe disease_ontology DOID:1056 OMIM mapping confirmed by DO. [SN]. oculocerebrorenal syndrome A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone. GARD:7285 ICD9CM:268.2 NCI:C26838 SNOMEDCT_US_2020_03_01:190639009 UMLS_CUI:C0029442 disease_ontology DOID:10573 osteomalacia MESH:D010018 ICD10CM:E83.5 ICD9CM:275.4 MESH:D002128 SNOMEDCT_US_2020_03_01:267442002 UMLS_CUI:C0006705 disease_ontology DOID:10575 calcium metabolism disease A cerebral degeneration characterized by dysfunction of the white matter of the brain. GARD:6895 ICD9CM:330.0 NCI:C61253 SNOMEDCT_US_2020_03_01:5101009 UMLS_CUI:C0023520 disease_ontology DOID:10579 leukodystrophy A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system. GARD:3230 ICD10CM:E75.25 MESH:D007966 NCI:C61251 OMIM:249900 OMIM:250100 ORDO:512 SNOMEDCT_US_2020_03_01:3621006 UMLS_CUI:C0023522 MLD Scholz cerebral sclerosis arylsulfatase A deficiency deficiency of cerebroside-sulfatase sulfatide lipoidosis disease_ontology DOID:10581 Xref MGI. OMIM mapping confirmed by DO. [SN]. metachromatic leukodystrophy GARD:5691 ICD10CM:G60.1 ICD9CM:356.3 MESH:D012035 NCI:C85043 OMIM:266500 OMIM:266510 SNOMEDCT_US_2020_03_01:25362006 UMLS_CUI:C0034960 HMSN type IV HSMN IV Heredopathia atactica polyneuritiformis Refsum's disease disease_ontology DOID:10582 OMIM mapping confirmed by DO. [SN]. Refsum disease A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss. DOID:14742 GARD:5694 ICD10CM:H35.52 MESH:C538365 MESH:D012174 NCI:C85045 OMIM:PS268000 ORDO:791 SNOMEDCT_US_2020_03_01:155113002 UMLS_CUI:C0035334 UMLS_CUI:C0220701 pericentral pigmentary retinopathy disease_ontology DOID:10584 Xref MGI. OMIM mapping confirmed by DO. [LS]. retinitis pigmentosa GARD:6844 ICD10CM:E75.23 MESH:D007965 NCI:C61254 OMIM:245200 SNOMEDCT_US_2020_03_01:192782005 UMLS_CUI:C0023521 Diffuse globoInOwlid body sclerosis GLOBOID CELL LEUKOENCEPHALOPATHY Galactosylceramide beta-galactosidase deficiency Krabbe's disease Krabbe's leukodystrophy beta galactocerebrosidase deficiency globoInOwlid cell leukodystrophy disease_ontology DOID:10587 OMIM mapping confirmed by DO. [SN]. Krabbe disease A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death. DOID:13451 ICD10CM:E71.52 MESH:D000326 NCI:C61252 OMIM:300100 SNOMEDCT_US_2020_03_01:65389002 UMLS_CUI:C0162309 ALD Bronze Schilder disease Encephalitis periaxialis concentrica Encephalitis periaxialis, Schilder's Siemerling-Creutzfeldt Disease X-linked adrenoleukodystrophy diffuse sclerosis sudanophilic cerebral sclerosis disease_ontology DOID:10588 MESH:D000326w added from NeuroDevNet [WAK]. adrenoleukodystrophy MESH:D000326 A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. NCI:C84392 SNOMEDCT_US_2020_03_01:1855002 UMLS_CUI:C0025362 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15 disease_ontology mental retardation DOID:1059 OMIM mapping submitted by NeuroDevNet. [LS]. intellectual disability A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 SNOMEDCT_US_2020_03_01:6758009 UMLS_CUI:C0032914 gestational hypertension hypertension induced by pregnancy pre-eclamptic toxaemia preeclampsia preeclampsia/eclampsia pregnancy associated hypertension pregnancy toxemia proteinuric hypertension of pregnancy toxaemia of pregnancy disease_ontology DOID:10591 Xref MGI. OMIM mapping confirmed by DO. [SN]. pre-eclampsia A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm. GARD:6034 ICD10CM:G60.0 ICD9CM:356.1 MESH:D002607 NCI:C75467 OMIM:PS118220 SNOMEDCT_US_2020_03_01:193158000 UMLS_CUI:C0007959 CMT - Charcot-Marie-Tooth disease disease_ontology DOID:10595 Charcot-Marie-Tooth disease An amino acid metabolic disorder that is caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum. GARD:6569 ICD10CM:E72.02 MESH:D006250 NCI:C84748 OMIM:234500 SNOMEDCT_US_2020_03_01:80902009 UMLS_CUI:C0018609 Neutral 1 amino acid transport defect deficiency of tryptophan oxygenase neutral amino acid transport defect disease_ontology DOID:1060 OMIM mapping confirmed by DO. [SN]. Hartnup disease A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year. ICD10CM:F95.1 ICD9CM:307.22 MESH:D013981 NCI:C116768 SNOMEDCT_US_2020_03_01:192623005 UMLS_CUI:C0008701 chronic motor or vocal tic disorder disease_ontology DOID:10600 chronic tic disorder ICD10CM:R73.03 MESH:D018149 NCI:C34646 SNOMEDCT_US_2020_03_01:267426009 UMLS_CUI:C0271650 Glucose: intolerance Glucose: malabsorption Malabsorption of glucose disease_ontology DOID:10603 glucose intolerance ICD10CM:E73 MESH:D007787 NCI:C3154 OMIM:223100 SNOMEDCT_US_2020_03_01:267497007 UMLS_CUI:C0022951 LM - Lactose malabsorption disease_ontology DOID:10604 OMIM mapping confirmed by DO. [SN]. lactose intolerance MESH:D007787 An intestinal disease that is characterized by a reduced ability to absorb nutrients due to the physical loss or the loss of function of a portion of the small and/or large intestine. MESH:D012778 NCI:C99059 SNOMEDCT_US_2020_03_01:204768009 UMLS_CUI:C0036992 acquired short bowel syndrome short gut syndrome disease_ontology DOID:10605 short bowel syndrome An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption. ICD10CM:K90.2 ICD9CM:579.2 MESH:D001765 NCI:C34431 SNOMEDCT_US_2020_03_01:77225009 UMLS_CUI:C0005750 Bacterial overgrowth syndrome Blind loop syndrome disease_ontology DOID:10606 blind loop syndrome GARD:7824 ICD10CM:K90.1 ICD9CM:579.1 MESH:D013182 NCI:C45428 SNOMEDCT_US_2020_03_01:155846005 UMLS_CUI:C0038054 Sprue - tropical Tropical steatorrhea disease_ontology DOID:10607 tropical sprue An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. EFO:0001060 GARD:11998 ICD10CM:K90.0 ICD9CM:579.0 MESH:D002446 NCI:C26714 OMIM:607202 OMIM:609754 OMIM:611598 OMIM:612005 OMIM:612006 OMIM:612007 OMIM:612008 OMIM:612009 OMIM:612011 ORDO:555 SNOMEDCT_US_2020_03_01:197477005 UMLS_CUI:C0007570 celiac sprue coeliac disease idiopathic steatorrhea disease_ontology DOID:10608 Xref MGI. OMIM mapping confirmed by DO. [SN]. celiac disease A bone remodeling disease that has_material_basis_in impaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone. DOID:11672 GARD:5700 ICD10CM:E55.0 ICD9CM:268.0 MESH:D012279 NCI:C26878 OMIM:264700 OMIM:277440 OMIM:600081 OMIM:600785 ORDO:289157 SNOMEDCT_US_2020_03_01:190639009 SNOMEDCT_US_2020_03_01:68295002 UMLS_CUI:C0035579 UMLS_CUI:C0221468 active rickets vitamin D hydroxylation-deficient rickets vitamin D-dependent rickets disease_ontology DOID:10609 Xref MGI. rickets MESH:D012279 ICD10CM:K90.3 ICD9CM:579.4 SNOMEDCT_US_2020_03_01:155845009 UMLS_CUI:C0152166 pancreatic steatorrhoea disease_ontology DOID:10610 pancreatic steatorrhea MESH:D011504 OMIM:226300 SNOMEDCT_US_2020_03_01:66972006 UMLS_CUI:C0033680 Enteropathy, exudative Exudative enteropathy Protein-losing enteropathy disease_ontology DOID:10611 OMIM mapping confirmed by DO. [SN]. protein-losing enteropathy An urticaria that is characterized by erythematous papules and plaques, has_symptom pruritis, and has_material_basis_in allergic reaction. ICD10CM:L50.0 ICD9CM:708.0 SNOMEDCT_US_2020_03_01:201260002 UMLS_CUI:C0149526 Allergic urticaria disease_ontology DOID:10612 allergic urticaria A renal tubular transport disease of the proximal renal tubes characterized by glucosuria, phosphaturia, generalized aminoaciduria and HCO3 wasting. DOID:5956 GARD:9118 MESH:D005198 NCI:C3034 NCI:C4377 OMIM:PS134600 ORDO:3337 SNOMEDCT_US_2020_03_01:236468006 SNOMEDCT_US_2020_03_01:40488004 UMLS_CUI:C0015624 UMLS_CUI:C0341703 Congenital Fanconi syndrome De Toni-Fanconi syndrome Fanconi-de Toni syndrome Fanconi-de-Toni syndrome Infantile nephropathic cystinosis Lignac-Fanconi syndrome adult Fanconi Anemia adult Fanconi syndrome deToni Fanconi syndrome disease_ontology DOID:1062 Xref MGI. OMIM mapping confirmed by DO. [SN]. Fanconi syndrome MESH:D005198 An eye disease where one or both eyeballs are abnormally small. DOID:10650 GARD:12085 ICD10CM:Q11.2 ICD9CM:743.1 MESH:D008850 NCI:C98989 SNOMEDCT_US_2020_03_01:156902006 UMLS_CUI:C0026010 microphthalmos simple microphthalmos disease_ontology DOID:10629 Xref MGI. OMIM mapping confirmed by DO. [SN]. microphthalmia ICD10CM:N12 MESH:D009395 NCI:C26834 SNOMEDCT_US_2020_03_01:28689008 UMLS_CUI:C0027707 renal tubulo-interstitial disease disease_ontology DOID:1063 interstitial nephritis A syndrome that is characterized by diabetes mellitus, optic atrophy, and deafness. GARD:7898 MESH:D014929 NCI:C35133 ORDO:3463 SNOMEDCT_US_2020_03_01:70694009 UMLS_CUI:C0043207 disease_ontology DOID:10632 OMIM mapping confirmed by DO. [LS]. Wolfram syndrome A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and that has_material_basis_in mutations in the CTNS gene, located on chromosome 17. GARD:6236 MESH:D003554 NCI:C129932 OMIM:219750 OMIM:219800 OMIM:219900 ORDO:213 SNOMEDCT_US_2020_03_01:62332007 UMLS_CUI:C2931187 cystine storage disease disease_ontology DOID:1064 cystinosis A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs. ICD10CM:F21 ICD9CM:301.22 MESH:D012569 NCI:C92632 SNOMEDCT_US_2020_03_01:231486008 UMLS_CUI:C0036363 disease_ontology DOID:10646 schizotypal personality disorder A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. EFO:0000249 GARD:10254 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 SNOMEDCT_US_2020_03_01:73768007 UMLS_CUI:C0002395 Alzheimer disease Alzheimers dementia disease_ontology DOID:10652 Xref MGI. OMIM mapping confirmed by DO. [SN]. Alzheimer's disease NCI:C5493 UMLS_CUI:C0940607 Colonic Lipoma disease_ontology DOID:10655 lipoma of colon A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage. EFO:0004190 ICD10CM:H40.1 ICD9CM:365.1 MESH:D005902 NCI:C34641 OMIM:137750 OMIM:177700 OMIM:602429 OMIM:603383 OMIM:606689 OMIM:608695 OMIM:608696 OMIM:609745 OMIM:609887 OMIM:610535 OMIM:611274 OMIM:611276 OMIM:613100 SNOMEDCT_US_2020_03_01:84494001 UMLS_CUI:C0017612 Wide-angle glaucoma glaucoma simplex open angle glaucoma pigmentary glaucoma disease_ontology DOID:1067 Xref MGI. open-angle glaucoma A breast disease characterized by painful infection of the breast tissue. MESH:D008413 NCI:C53662 SNOMEDCT_US_2020_03_01:155952005 UMLS_CUI:C0024894 Inflammatory breast disease Inflammatory disease of breast breast inflammation disease_ontology DOID:10690 mastitis ICD9CM:360.03 SNOMEDCT_US_2020_03_01:193269007 UMLS_CUI:C0154774 disease_ontology DOID:10697 chronic endophthalmitis A parasitic helminthiasis infectious disease that involves parasitic infection by flukes of the genus Paragonimus. In the acute phase, the symptoms are diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. Pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Various organs like brain, spleen and liver can be infected. GARD:9815 ICD10CM:B66.4 ICD9CM:121.2 MESH:D010237 NCI:C84995 SNOMEDCT_US_2020_03_01:30369007 UMLS_CUI:C0030424 Infection by Paragonimus lung fluke disease lung fluke infection pulmonary paragonimiasis disease_ontology DOID:10699 paragonimiasis An open-angle glaucoma that is characterized by the absence of any apparent obstruction of aqueous outflow through the trabecular meshwork with gonioscopy, but often with elevated intraocular pressure. ICD10CM:H40.11 ICD9CM:365.11 MESH:D005902 NCI:C35394 OMIM:137760 SNOMEDCT_US_2020_03_01:77075001 UMLS_CUI:C0339573 chronic simple glaucoma disease_ontology DOID:1070 OMIM mapping confirmed by DO. [SN]. primary open angle glaucoma A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting. ICD10CM:A07.1 ICD9CM:007.1 MESH:D005873 SNOMEDCT_US_2020_03_01:266176008 UMLS_CUI:C0017536 Infection by Giardia lamblia beaver feaver disease_ontology DOID:10718 giardiasis GARD:6549 ICD9CM:242.00 UMLS_CUI:C0154138 disease_ontology DOID:10719 toxic diffuse goiter A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. ICD10CM:N19 ICD9CM:586 MESH:D051437 NCI:C4376 SNOMEDCT_US_2020_03_01:42399005 UMLS_CUI:C0035078 renal failure disease_ontology DOID:1074 PRISM. kidney failure ICD9CM:330.1 SNOMEDCT_US_2020_03_01:16517004 UMLS_CUI:C0007788 disease_ontology DOID:10742 cerebral lipidosis A otitis which involves inflammation of the middle ear. ICD10CM:H66.9 ICD9CM:382.9 MESH:D010033 NCI:C34885 SNOMEDCT_US_2020_03_01:65363002 UMLS_CUI:C0029882 disease_ontology DOID:10754 otitis media ICD10CM:N11 ICD9CM:590.0 NCI:C123216 SNOMEDCT_US_2020_03_01:123293005 UMLS_CUI:C0085697 disease_ontology DOID:1076 chronic pyelonephritis GARD:8229 ICD10CM:K76.6 ICD9CM:572.3 MESH:D006975 NCI:C3119 SNOMEDCT_US_2020_03_01:155821005 UMLS_CUI:C0020541 disease_ontology DOID:10762 portal hypertension An artery disease characterized by chronic elevated blood pressure in the arteries. EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 MESH:D006973 NCI:C3117 SNOMEDCT_US_2020_03_01:38341003 UMLS_CUI:C0020538 HTN High blood pressure hyperpiesia vascular hypertensive disorder disease_ontology hypertensive disease DOID:10763 hypertension GARD:9430 ICD10CM:M31.1 MESH:D011697 NCI:C78797 OMIM:274150 SNOMEDCT_US_2020_03_01:360402008 UMLS_CUI:C0034155 Moschcowitz's syndrome disease_ontology DOID:10772 thrombotic thrombocytopenic purpura ICD10CM:I40.1 ICD9CM:422.91 SNOMEDCT_US_2020_03_01:194954007 UMLS_CUI:C0155689 Idiopathic myocarditis Isolated (Fiedler's) myocarditis fiedler myocarditis disease_ontology DOID:10778 fiedler's myocarditis ICD10CM:D74 ICD9CM:289.7 MESH:D008708 NCI:C34817 SNOMEDCT_US_2020_03_01:191386007 UMLS_CUI:C0025637 disease_ontology DOID:10783 methemoglobinemia A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy. DOID:0050038 Australian tick typhus Rickettsia australis spotted fever disease_ontology North Queensland tick typhus DOID:10784 Queensland tick typhus A sinusitis which involves infection of the frontal sinuses over the eyes in the brow area. This causes pain or pressure in the frontal sinus cavity and headache over the forehead. ICD10CM:J32.1 MESH:D015522 NCI:C34626 SNOMEDCT_US_2020_03_01:275485006 UMLS_CUI:C0016735 disease_ontology DOID:10791 frontal sinusitis A maxillary sinusitis which lasts for 12 weeks or more. ICD10CM:J32.0 ICD9CM:473.0 NCI:C34477 SNOMEDCT_US_2020_03_01:195785003 UMLS_CUI:C0008698 chronic antritis disease_ontology DOID:10792 chronic maxillary sinusitis A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head. ICD10CM:J32.3 MESH:D015524 NCI:C35031 SNOMEDCT_US_2020_03_01:13266007 UMLS_CUI:C0037886 Sphenoidal sinusitis disease_ontology DOID:10794 sphenoid sinusitis A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea. ICD10CM:B74 ICD9CM:125.9 MESH:D005368 NCI:C34611 SNOMEDCT_US_2020_03_01:50342004 UMLS_CUI:C0016085 disease due to superfamily Filarioidea disease_ontology DOID:1080 filariasis MESH:D005368 A respiratory system cancer that is located_in the nasal cavity. ICD10CM:C30.0 ICD9CM:160.0 NCI:C4918 SNOMEDCT_US_2020_03_01:93917007 UMLS_CUI:C0728864 malignant neoplasm of nasal cavities malignant tumor of the nasal cavity disease_ontology DOID:10811 nasal cavity cancer NCI:C6074 UMLS_CUI:C1334921 Lymphoma of the nasal cavity lymphoma of nasal cavity disease_ontology DOID:10813 nasal cavity lymphoma A duodenum cancer that derives_from epithelial cells of glandular origin. NCI:C7889 SNOMEDCT_US_2020_03_01:408644002 UMLS_CUI:C0278804 Duodenal adenocarcinoma disease_ontology DOID:10816 duodenum adenocarcinoma A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions. GARD:11908 ICD10CM:B74.8 MESH:D004184 SNOMEDCT_US_2020_03_01:73328005 UMLS_CUI:C0012602 Dirofilaria infectious disease Infection by Dirofilaria disease_ontology DOID:1082 dirofilariasis ICD10CM:F65.3 ICD9CM:302.82 MESH:D014843 NCI:C94360 SNOMEDCT_US_2020_03_01:192515002 UMLS_CUI:C0042979 disease_ontology DOID:10834 voyeurism A viral infectious disease that results in inflammation located in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted by Aedes, transmitted by Coquillettidia, and transmitted by Culex species of mosquitoes. The infection has symptom sudden onset of headache, has symptom high fever, has symptom chills, has symptom vomiting, has symptom disorientation, has symptom seizures, and has symptom coma. GARD:10821 ICD10CM:A83.2 ICD9CM:062.2 MESH:D020242 SNOMEDCT_US_2020_03_01:40177004 UMLS_CUI:C0153065 Neuroinvasive Eastern equine encephalitis virus infection disease_ontology EEE DOID:10841 Eastern equine encephalitis A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness. ICD10CM:A83.4 ICD9CM:062.4 SNOMEDCT_US_2020_03_01:66454007 UMLS_CUI:C0153066 Australian X disease Australian encephalitis disease_ontology DOID:10842 Murray Valley encephalitis A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness. GARD:7888 ICD10CM:A83.1 ICD9CM:062.1 MESH:D020241 NCI:C85227 SNOMEDCT_US_2020_03_01:47523006 UMLS_CUI:C0153064 disease_ontology WEE DOID:10843 Western equine encephalitis A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis. GARD:6797 ICD10CM:A83.0 ICD9CM:062.0 MESH:D004672 NCI:C34577 SNOMEDCT_US_2020_03_01:266194002 UMLS_CUI:C0014057 Japanese B encephalitis disease_ontology DOID:10844 Japanese encephalitis A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis. ICD10CM:A83.3 ICD9CM:062.3 MESH:D004674 SNOMEDCT_US_2020_03_01:10429004 UMLS_CUI:C0014060 Neuroinvasive St. Louis encephalitis virus infection disease_ontology DOID:10845 St. Louis encephalitis A chromosomal duplciation syndrome that is characterized by slow growth before birth and a low birth weight and that has_material_basis_in three copies of chromosome 18. ICD9CM:758.2 MESH:D000073842 NCI:C101362 SNOMEDCT_US_2020_03_01:51500006 UMLS_CUI:C0152096 Complete trisomy 18 syndrome E3 Trisomy trisomy 18 disease_ontology DOID:1085 OMIM mapping confirmed by DO. [LS]. Edwards syndrome A mouth disease located_in the salivary gland. DOID:12898 ICD9CM:527.8 UMLS_CUI:C0029773 Non-neoplastic Salivary gland disease Salivary gland disease disease_ontology DOID:10854 salivary gland disease ICD10CM:H49 ICD9CM:378.5 SNOMEDCT_US_2020_03_01:12942001 UMLS_CUI:C0152221 Incomitant dissociation Paralytic strabismus disease_ontology DOID:10863 paralytic squint A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision. EFO:0001365 ICD10CM:H35.30 ICD9CM:362.50 MESH:D008268 NCI:C84391 OMIM:PS603075 SNOMEDCT_US_2020_03_01:18222007 UMLS_CUI:C0242383 Age Related Maculopathies Age Related Maculopathy Senile macular degeneration Senile macular retinal degeneration age-related macular degeneration disease_ontology DOID:10871 OMIM mapping confirmed by DO. [SN]. age related macular degeneration ICD10CM:H35.32 ICD9CM:362.52 SNOMEDCT_US_2020_03_01:11290001 UMLS_CUI:C0271084 Exudative senile macular degeneration of retina Neovascular age-related macular degeneration Senile macular degeneration, wet Wet senile macular retinal degeneration disease_ontology DOID:10873 Kuhnt-Junius degeneration A spina bifida that is characterized by herniation of the meninges between the vertebrae. SNOMEDCT_US_2020_03_01:268308005 UMLS_CUI:C0025299 disease_ontology DOID:1088 meningocele MESH:D008588 A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet. ICD10CM:B08.4 ICD9CM:074.3 MESH:D006232 NCI:C128439 SNOMEDCT_US_2020_03_01:175497008 UMLS_CUI:C0018572 Vesicular stomatitis and exanthem disease_ontology DOID:10881 hand, foot and mouth disease A viral infectious disease that results in necrosis located in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has symptom severe chest pain, has symptom fever, has symptom malaise, has symptom pleuritis, and has symptom headache. ICD10CM:B33.0 ICD9CM:074.1 MESH:D011000 SNOMEDCT_US_2020_03_01:83264000 UMLS_CUI:C0032238 Bamble disease Bornholm disease Epidemic pleurisy Epidemic, myositis devil's grip epidemic myalgia disease_ontology DOID:10882 epidemic pleurodynia A viral infectious disease that results in infection located in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars. ICD10CM:B08.5 ICD9CM:074.0 MESH:D006557 SNOMEDCT_US_2020_03_01:154358007 UMLS_CUI:C0019338 Vesicular pharyngitis disease_ontology DOID:10883 herpangina GARD:4018 SNOMEDCT_US_2020_03_01:282784007 UMLS_CUI:C0560648 spinal dysraphism disease_ontology DOID:1089 OMIM mapping confirmed by DO. [LS]. tethered spinal cord syndrome NCI:C99080 A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum. ICD10CM:Q54 MESH:D007021 NCI:C40341 OMIM:146450 OMIM:300633 OMIM:300758 OMIM:300856 ORDO:440 SNOMEDCT_US_2020_03_01:156968008 UMLS_CUI:C0848558 familial hypospadias disease_ontology DOID:10892 Xref MGI. OMIM mapping confirmed by DO. [SN]. hypospadias A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants. GARD:3603 GARD:7038 ICD10CM:Q02 ICD9CM:742.1 MESH:D008831 NCI:C85874 SNOMEDCT_US_2020_03_01:156893009 UMLS_CUI:C0025958 Microcephalus microencephaly disease_ontology DOID:10907 OMIM mapping confirmed by DO. [SN]. microcephaly MESH:D008831 A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head. GARD:6682 ICD10CM:G91 MESH:D006849 NCI:C3111 OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219 ORDO:2182 ORDO:2185 SNOMEDCT_US_2020_03_01:267687006 UMLS_CUI:C0020255 hydrocephalus, X-linked hydrocephalus, nonsyndromic, autosomal recessive disease_ontology DOID:10908 Xref MGI. OMIM mapping confirmed by DO. [SN]. hydrocephalus A mouth disease located_in the teeth. MESH:D014076 SNOMEDCT_US_2020_03_01:72722003 UMLS_CUI:C0040435 teeth disease disease_ontology DOID:1091 tooth disease A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information. DOID:4544 ICD10CM:R41.3 ICD9CM:294.0 MESH:D000647 NCI:C2867 SNOMEDCT_US_2020_03_01:247606008 SNOMEDCT_US_2020_03_01:3298001 UMLS_CUI:C0002622 UMLS_CUI:C0002625 Amnestic syndrome Korsakoff's psychosis or syndrome amnesia disease_ontology DOID:10914 amnestic disorder A nutritional deficiency disease that is characterized by ophthalmoplegia, ataxia, change in mental status and acute onset of severe memory impairment without any dysfunction in intellectual abilities, and has_material_basis_in thiamine deficiency. MESH:D020915 NCI:C35764 OMIM:277730 SNOMEDCT_US_2020_03_01:69482004 UMLS_CUI:C0349464 Korsakoff Syndrome Korsakoff's psychosis Korsakoff's syndrome Korsakov psychosis Korsakov's psychosis disease_ontology DOID:10915 OMIM mapping confirmed by DO. [LS]. Wernicke-Korsakoff syndrome A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex. ICD9CM:302.50 SNOMEDCT_US_2020_03_01:191782007 UMLS_CUI:C0040630 disease_ontology DOID:10919 transsexualism A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape. DOID:12924 DOID:13024 GARD:8614 ICD10CM:D57.1 ICD10CM:D57.2 ICD9CM:282.6 ICD9CM:282.63 MESH:D000755 MESH:D006450 NCI:C34383 NCI:C34676 OMIM:603903 ORDO:232 SNOMEDCT_US_2020_03_01:154798006 SNOMEDCT_US_2020_03_01:35434009 UMLS_CUI:C0002895 UMLS_CUI:C0019034 Hb SC disease Hb-S/Hb-C disease Hb-SS disease without crisis Hemoglobin S disease without crisis Sickle-cell/Hb-C disease without crisis drepanocytosis haemoglobin SC disease hemoglobin SC disease sickle cell anaemia disease_ontology DOID:10923 OMIM mapping confirmed by DO. [LS]. sickle cell anemia A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods. ICD10CM:F60.3 ICD9CM:301.83 MESH:D001883 NCI:C92633 SNOMEDCT_US_2020_03_01:20010003 UMLS_CUI:C0006012 disease_ontology DOID:10930 borderline personality disorder A personality disorder that is characterized by a pervasive psychological dependence on other people. ICD10CM:F60.7 ICD9CM:301.6 MESH:D003859 NCI:C92637 SNOMEDCT_US_2020_03_01:192492003 UMLS_CUI:C0011548 disease_ontology DOID:10931 dependent personality disorder A personality disorder that is characterized by a pervasive pattern of preoccupation with orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency. ICD10CM:F60.5 ICD9CM:301.4 MESH:D003193 NCI:C92638 SNOMEDCT_US_2020_03_01:191761001 UMLS_CUI:C0009595 OCPD disease_ontology Anankastic personality disorder DOID:10932 obsessive-compulsive personality disorder A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities. ICD10CM:F44.81 ICD9CM:300.14 MESH:D009105 NCI:C94330 SNOMEDCT_US_2020_03_01:31611000 UMLS_CUI:C0026773 Dissociative identity disorder disease_ontology DOID:10934 multiple personality disorder A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated). DOID:4963 ICD10CM:F44.9 ICD10CM:F48.9 ICD9CM:300.15 ICD9CM:300.9 MESH:D004213 NCI:C92197 SNOMEDCT_US_2020_03_01:154883004 UMLS_CUI:C0012746 UMLS_CUI:C0041857 dissociative disease dissociative reaction disease_ontology DOID:10935 dissociative disorder A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world. ICD10CM:F60.1 ICD9CM:301.2 MESH:D012557 NCI:C92631 SNOMEDCT_US_2020_03_01:192486009 UMLS_CUI:C0036339 disease_ontology DOID:10936 schizoid personality disorder A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others. ICD10CM:F63.9 ICD9CM:312.30 MESH:D007174 NCI:C34723 SNOMEDCT_US_2020_03_01:192098008 UMLS_CUI:C0021122 disease_ontology DOID:10937 impulse control disorder A personality disorder that is characterized by paranoia and a pervasive, long-standing suspiciousness and generalized mistrust of others. ICD10CM:F60.0 ICD9CM:301.0 MESH:D010260 NCI:C92630 SNOMEDCT_US_2020_03_01:270529002 UMLS_CUI:C0030477 disease_ontology DOID:10938 paranoid personality disorder A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. ICD10CM:F60.2 ICD9CM:301.7 MESH:D000987 NCI:C88413 SNOMEDCT_US_2020_03_01:191769004 UMLS_CUI:C0003431 Asocial personality Dissocial personality disorder Psychopath.personality Psychopathic personality Psychopathic personality disorder sociopathic personality disease_ontology DOID:10939 antisocial personality disorder A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age. DOID:1093 EFO:0003888 MESH:D001289 NCI:C35092 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 SNOMEDCT_US_2020_03_01:229713001 UMLS_CUI:C0041671 ADHD attention deficit disorder hyperkinetic disorder disease_ontology DOID:1094 Xref MGI. attention deficit hyperactivity disorder EFO:0003870 MESH:D002532 NCI:C34458 SNOMEDCT_US_2020_03_01:128609009 UMLS_CUI:C0007766 brain aneurysm disease_ontology DOID:10941 intracranial aneurysm A mouth disease located_in the tongue. ICD10CM:K14 ICD9CM:529.9 MESH:D014060 SNOMEDCT_US_2020_03_01:69244009 UMLS_CUI:C0040409 disease_ontology DOID:10944 tongue disease A kidney disease that is characterized by an inflammation of the kidneys. ICD10CM:N08 MESH:D009393 NCI:C26833 SNOMEDCT_US_2020_03_01:52845002 UMLS_CUI:C0027697 disease_ontology DOID:10952 nephritis A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis. DOID:0050008 GARD:8195 ICD10CM:B78 ICD9CM:127.2 MESH:D013322 NCI:C128398 SNOMEDCT_US_2020_03_01:1214006 UMLS_CUI:C0038463 Infection by Strongyloides disseminated strongyloidiasis disease_ontology DOID:10955 strongyloidiasis A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. The legs cross at the knees, making it difficult to walk. DOID:3778 ICD10CM:G80.1 ICD9CM:343.0 MESH:D002547 NCI:C34781 SNOMEDCT_US_2020_03_01:1178005 SNOMEDCT_US_2020_03_01:275469001 UMLS_CUI:C0023882 UMLS_CUI:C0154695 Diplegic infantile cerebral palsy Infantile spastic cerebral palsy Little's disease Littles disease cerebral spastic infantile paralysis infantile diplegic cerebral palsy disease_ontology DOID:10965 spastic diplegia A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally. GARD:10448 ICD9CM:343.1 SNOMEDCT_US_2020_03_01:258714003 UMLS_CUI:C0270805 Congenital hemiplegia Hemiplegic cerebral palsy Hemiplegic infantile cerebral palsy hemiplegic cerebral palsy spastic hemiplegic cerebral palsy disease_ontology DOID:10967 spastic hemiplegia A central nervous system disease that is characterized by the complete paralysis of half of the body. GARD:6583 ICD9CM:343.4 MESH:D006429 SNOMEDCT_US_2020_03_01:155024003 UMLS_CUI:C0392550 Infantile hemiplegia Postnatal infantile hemiplegia disease_ontology DOID:10969 hemiplegia A spastic cerebral palsy that affects all four limbs. The individuals have difficulty with walking and talking. ICD9CM:343.2 MESH:D002547 OMIM:603513 OMIM:612900 ORDO:210141 SNOMEDCT_US_2020_03_01:192953000 UMLS_CUI:C0154697 quadriplegic infantile cerebral palsy spastic quadriplegic cerebral palsy tetraplegic infantile cerebral palsy disease_ontology DOID:10970 Xref MGI. spastic quadriplegia ICD10CM:N70 ICD9CM:614.2 SNOMEDCT_US_2020_03_01:46536000 UMLS_CUI:C0036133 Salpingitis/oophoritis Tubo-ovarian inflammatory disease disease_ontology DOID:10972 salpingo-oophoritis ICD10CM:N70.01 NCI:C40120 SNOMEDCT_US_2020_03_01:8912009 UMLS_CUI:C0269038 disease_ontology DOID:10973 acute salpingitis An ovarian disease that is characterized by inflammation of the ovary. ICD10CM:N70.92 MESH:D009869 SNOMEDCT_US_2020_03_01:266648001 UMLS_CUI:C0029051 disease_ontology DOID:10974 oophoritis EFO:0004254 ICD10CM:N03.2 MESH:D015433 NCI:C34645 SNOMEDCT_US_2020_03_01:197710000 UMLS_CUI:C0017665 membranous nephropathy disease_ontology DOID:10976 membranous glomerulonephritis A syndrome disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss. GARD:5785 MESH:D009394 ORDO:63 SNOMEDCT_US_2020_03_01:57333009 UMLS_CUI:C0027706 Hereditary Nephritis disease_ontology DOID:10983 OMIM mapping confirmed by DO. [SN]. Alport syndrome Alpha thalassemia is a thalassemia involving the genes HBA1and HBA2 hemoglobin genes. GARD:621 ICD10CM:D56.0 ICD9CM:282.43 MESH:D017085 NCI:C34368 OMIM:604131 SNOMEDCT_US_2020_03_01:191186002 UMLS_CUI:C0002312 Alpha thalassaemia alpha-Thalassemia disease_ontology DOID:1099 OMIM mapping confirmed by DO. [SN]. alpha thalassemia A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema. GARD:8629 MESH:D004684 NCI:C84535 OMIM:606752 SNOMEDCT_US_2020_03_01:72986009 UMLS_CUI:C0014077 AHL Weston-Hurst syndrome acute haemorrhagic leucoencephalitis of Weston Hurst acute hemorrhagic encephalomyelitis acute necrotizing hemorrhagic leukoencephalitis disease_ontology DOID:10992 OMIM mapping confirmed by DO. [SN]. acute hemorrhagic leukoencephalitis An eye disease that affects the lens of the eye, which is the transparent disc that focuses light to the photosensors in the back of the eye. ICD10CM:H27.9 MESH:D007905 NCI:C26812 SNOMEDCT_US_2020_03_01:194613002 UMLS_CUI:C0023308 disease_ontology DOID:110 lens disease A female reproductive system disease that is located_in the ovary. MESH:D010049 NCI:C26841 SNOMEDCT_US_2020_03_01:5552004 UMLS_CUI:C0029928 disease_ontology DOID:1100 ovarian disease ICD9CM:372.52 SNOMEDCT_US_2020_03_01:66139007 UMLS_CUI:C0155161 disease_ontology DOID:11028 pseudopterygium ICD10CM:H11.15 ICD9CM:372.51 MESH:D059407 NCI:C129468 SNOMEDCT_US_2020_03_01:267735001 UMLS_CUI:C0152255 disease_ontology DOID:11029 pinguecula ICD10CM:H18.20 ICD9CM:371.2 MESH:D015715 NCI:C50508 SNOMEDCT_US_2020_03_01:193811006 UMLS_CUI:C0010037 Corneal oedema disease_ontology DOID:11030 corneal edema ICD10CM:H18.1 ICD9CM:371.23 NCI:C26970 SNOMEDCT_US_2020_03_01:193815002 UMLS_CUI:C0155111 disease_ontology DOID:11031 bullous keratopathy ICD10CM:H18.22 ICD9CM:371.21 SNOMEDCT_US_2020_03_01:193813009 UMLS_CUI:C0155109 disease_ontology DOID:11033 idiopathic corneal edema A dissociative disorder where he continuity of the patient's memory is disrupted. Patients with dissociative amnesia have recurrent episodes in which they forget important personal information or events, usually connected with trauma or severe stress. ICD10CM:F44.0 ICD9CM:300.12 MESH:D000647 NCI:C94328 SNOMEDCT_US_2020_03_01:192420000 UMLS_CUI:C0236795 psychogenic amnesia disease_ontology DOID:11037 dissociative amnesia A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization. GARD:6260 ICD9CM:300.6 MESH:D003861 NCI:C94331 SNOMEDCT_US_2020_03_01:70764005 UMLS_CUI:C0683416 Neurotic derealization disease_ontology DOID:11038 depersonalization disorder A syndrome that results_in rheumatoid arthritis, splenomegaly and neutropenia. GARD:8234 ICD10CM:M05.0 ICD9CM:714.1 MESH:D005258 NCI:C84712 OMIM:134750 SNOMEDCT_US_2020_03_01:57160007 UMLS_CUI:C0015773 Felty syndrome Rheumatoid arthritis with splenoadenomegaly and leukopenia disease_ontology DOID:11042 OMIM mapping confirmed by DO. [SN]. Felty's syndrome GARD:8661 ICD10CM:Q79.3 ICD9CM:756.73 MESH:D020139 NCI:C84725 OMIM:230750 SNOMEDCT_US_2020_03_01:72951007 UMLS_CUI:C0265706 disease_ontology DOID:11044 OMIM mapping confirmed by DO. [SN]. gastroschisis A lung disease that is characterized by a newborn breathing in a mixture of meconium and amniotic fluid into the lungs around the time of delivery. GARD:10494 ICD10CM:P24.01 MESH:D008471 NCI:C87093 SNOMEDCT_US_2020_03_01:85779008 UMLS_CUI:C0025048 Neonatal aspiration of meconium meconium aspiration disease_ontology DOID:11049 meconium aspiration syndrome An urinary system cancer that results_in malignant growth located_in the urinary bladder. DOID:5428 GARD:12210 ICD10CM:C67 ICD9CM:188 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 SNOMEDCT_US_2020_03_01:126885006 SNOMEDCT_US_2020_03_01:363455001 UMLS_CUI:C0005684 UMLS_CUI:C0005695 bladder cancer tumor of the bladder disease_ontology DOID:11054 OMIM mapping confirmed by DO. [SN]. urinary bladder cancer A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia. ICD10CM:A28.0 ICD9CM:027.2 MESH:D010326 SNOMEDCT_US_2020_03_01:276199008 UMLS_CUI:C0030636 Pasteurella infection Pasteurella infectious disease disease_ontology DOID:11055 pasteurellosis A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix. ICD10CM:O44 MESH:D010923 NCI:C26858 SNOMEDCT_US_2020_03_01:157059004 UMLS_CUI:C0032046 disease_ontology DOID:11060 placenta praevia A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. EFO:0002916 NCI:C3513 SNOMEDCT_US_2020_03_01:255079005 UMLS_CUI:C0152018 cancer of esophagus cancer of oesophagus carcinoma OF ESOPHAGUS carcinoma of esophagus carcinoma of oesophagus disease_ontology DOID:1107 esophageal carcinoma A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue. DOID:0050060 GARD:5966 ICD10CM:A23 ICD9CM:023 MESH:D002006 NCI:C84602 SNOMEDCT_US_2020_03_01:154296006 UMLS_CUI:C0006309 Maltese fever undulant fever disease_ontology Bang's disease Gibraltar fever Malta fever Mediterranean fever DOID:11077 brucellosis A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue. ICD10CM:B87 ICD9CM:134.0 MESH:D009198 NCI:C128400 SNOMEDCT_US_2020_03_01:266225001 UMLS_CUI:C0027030 Infestation by fly larvae Infestation by maggots Maggot infestation disease_ontology DOID:11080 myiasis ICD10CM:H31.0 ICD9CM:363.3 SNOMEDCT_US_2020_03_01:53854005 UMLS_CUI:C0008512 disease_ontology DOID:11086 chorioretinal scar A respiratory system disease that is characterized by deprivation of oxygen to a newborn infant that lasts long enough during the birth process to cause physical harm, usually to the brain. GARD:5857 ICD10CM:P84 ICD9CM:768.9 MESH:D001238 SNOMEDCT_US_2020_03_01:413654009 UMLS_CUI:C0004045 Asphyxia - birth Asphyxia, in liveborn infant Birth asphyxia postnatal asphyxia disease_ontology DOID:11088 asphyxia neonatorum MESH:D001238 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia. GARD:7515 ICD10CM:A78 ICD9CM:083.0 MESH:D011778 NCI:C34970 SNOMEDCT_US_2020_03_01:266205000 UMLS_CUI:C0034362 Infection due to Coxiella burnetii disease_ontology DOID:11100 Q fever A primary bacterial infectious disease that results in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back. ICD10CM:A79.0 ICD9CM:083.1 MESH:D014205 SNOMEDCT_US_2020_03_01:82214002 UMLS_CUI:C0040830 His-Werner disease Quintan fever Wolhynian fever shin bone fever tibialgic fever disease_ontology DOID:11101 trench fever MESH:D014205 A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella. ICD10CM:A44 ICD9CM:088.0 MESH:D001474 NCI:C84586 SNOMEDCT_US_2020_03_01:17116008 UMLS_CUI:C0004771 Bartonella infectious disease Rochalimaea infection bartonelliasis disease_ontology DOID:11102 bartonellosis A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite. GARD:4998 ICD10CM:A77.9 ICD9CM:082.0 MESH:D000073605 SNOMEDCT_US_2020_03_01:186771002 UMLS_CUI:C0038041 Spotted fever group rickettsial disease disease_ontology DOID:11104 spotted fever A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement. MESH:C562733 OMIM:136880 SNOMEDCT_US_2020_03_01:68222009 UMLS_CUI:C0311338 Pigmentary retinal dystrophy retinitis punctata albescens disease_ontology DOID:11105 OMIM mapping confirmed by DO. [SN]. fundus albipunctatus ICD10CM:N13.30 ICD9CM:591 MESH:D006869 NCI:C26796 SNOMEDCT_US_2020_03_01:155866001 UMLS_CUI:C0020295 disease_ontology DOID:11111 hydronephrosis A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year. EFO:0004895 GARD:7783 ICD10CM:F95.2 ICD9CM:307.23 MESH:D005879 NCI:C35078 OMIM:137580 SNOMEDCT_US_2020_03_01:5158005 UMLS_CUI:C0040517 Guinon's disease Psychogenic tics Tourette syndrome motor-verbal tic disorder disease_ontology DOID:11119 OMIM mapping confirmed by DO. [SN]. Gilles de la Tourette syndrome ICD10CM:K04.0 ICD9CM:522.0 MESH:D011671 NCI:C52595 SNOMEDCT_US_2020_03_01:155638006 UMLS_CUI:C0034103 disease_ontology DOID:11121 pulpitis A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection. GARD:8204 ICD10CM:D69.0 ICD9CM:287.0 MESH:D011695 NCI:C34963 SNOMEDCT_US_2020_03_01:191306005 UMLS_CUI:C0034152 Allergic purpura Autoimmune purpura Henoch-Sch?nlein purpura Henoch-Sch@nlein purpura Henoch-Scholein purpura Henoch-Schonlein Purpura Purpura, autoimmune disease_ontology DOID:11123 Henoch-Schoenlein purpura disease_ontology DOID:11132 prostatic hypertrophy A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. DOID:3936 ICD10CM:C49 ICD9CM:171.9 SNOMEDCT_US_2020_03_01:93765001 UMLS_CUI:C0153519 connective and soft tissue neoplasm tumor of soft tissue and skeleton disease_ontology DOID:1115 sarcoma MESH:D041761 NCI:C34443 SNOMEDCT_US_2020_03_01:235919008 UMLS_CUI:C0947622 disease_ontology DOID:11151 cholecystolithiasis A miliaria that is characterized by erythematous papules resulting in leakage of sweat into the deeper, subcorneal layers of the epidermis provoking a local inflammatory reaction. ICD10CM:L74.0 ICD9CM:705.1 MESH:D008883 SNOMEDCT_US_2020_03_01:44279002 UMLS_CUI:C0162423 prickly heat disease_ontology DOID:11153 miliaria rubra A sweat gland disease that is characterized by reduced ability to sweat, has_symptom hyperthermia and dry skin of affected areas, and has_material_basis_in trauma to the sweat glands. ICD10CM:L74.4 MESH:D007007 NCI:C34718 SNOMEDCT_US_2020_03_01:201189007 UMLS_CUI:C0020620 Hypohidrosis Oligohidrosis disease_ontology DOID:11155 hypohidrosis MESH:D007007 A hypohidrosis that is characterized by the inability to sweat and has_symptom hyperthermia and dry skin. ICD10CM:L74.4 ICD9CM:705.0 MESH:D007007 NCI:C34385 OMIM:206600 SNOMEDCT_US_2020_03_01:201189007 UMLS_CUI:C0003028 Adiaphoresis absence of sweating disease_ontology DOID:11156 OMIM mapping confirmed by DO. [SN]. anhidrosis A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop). DOID:11333 DOID:11751 KEGG:05133 MESH:D001885 SNOMEDCT_US_2020_03_01:26484003 UMLS_CUI:C0006015 WC - Whooping cough bordetella infection whooping cough disease_ontology DOID:1116 pertussis A lung disease characterized by inadequate gas exchange by the respiratory system. DOID:11391 DOID:11392 DOID:11393 ICD10CM:J96.0 ICD9CM:518.81 NCI:C27043 SNOMEDCT_US_2020_03_01:65710008 UMLS_CUI:C0264490 acute and chronic respiratory failure acute respiratory Failure acute-on-chronic respiratory failure chronic respiratory failure respiratory insufficiency/failure disease_ontology DOID:11162 respiratory failure ICD10CM:H18.42 ICD9CM:371.43 MESH:C562399 NCI:C118765 OMIM:217500 SNOMEDCT_US_2020_03_01:35055000 UMLS_CUI:C0155120 Band-shaped keratopathy disease_ontology DOID:11164 OMIM mapping confirmed by DO. [SN]. band keratopathy A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body. ICD10CM:B07.8 ICD9CM:078.1 NCI:C27087 SNOMEDCT_US_2020_03_01:57019003 UMLS_CUI:C0043037 disease_ontology DOID:11165 common wart A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts. DOID:7877 ICD10CM:A63.0 ICD9CM:078.11 MESH:D003218 NCI:C2960 NCI:C4820 SNOMEDCT_US_2020_03_01:240542006 SNOMEDCT_US_2020_03_01:302812006 UMLS_CUI:C0009663 UMLS_CUI:C0554632 Anogenital Human papilloma Virus Infectious Disease Anogenital warts Genital warts genital wart virus infectious disease venereal wart disease_ontology Condyloma acuminatum DOID:11168 anogenital venereal wart ICD10CM:H05.4 ICD9CM:376.5 MESH:D015841 NCI:C79552 SNOMEDCT_US_2020_03_01:267746003 UMLS_CUI:C0014306 disease_ontology DOID:11175 enophthalmos A otitis media which involves transudation of fluid in the middle ear without pus formation. ICD10CM:H65 ICD9CM:381.4 SNOMEDCT_US_2020_03_01:275481002 UMLS_CUI:C0271446 Nonsuppurative otitis media disease_ontology DOID:11180 non-suppurative otitis media ICD10CM:H10.02 ICD9CM:372.03 UMLS_CUI:C0029668 disease_ontology DOID:11184 acute conjunctivitis A synostosis that results_in the fusion of two or more digits. GARD:13181 ICD10CM:Q70 ICD9CM:755.1 MESH:D013576 NCI:C87125 ORDO:295012 ORDO:90025 ORDO:93403 SNOMEDCT_US_2020_03_01:156989004 UMLS_CUI:C0039075 chromosome 2q35 duplication syndrome symphalangism symphalangy webbing of digits disease_ontology DOID:11193 Xref MGI. syndactyly MESH:D013576 A syndrome that has_material_basis_in a large deletion of the chromosome 22q11.2 region which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production. GARD:10299 ICD10CM:D82.1 ICD9CM:279.11 MESH:D004062 NCI:C2989 OMIM:188400 SNOMEDCT_US_2020_03_01:77128003 UMLS_CUI:C0012236 22q11.2 deletion syndrome DiGeorge sequence DiGeorge's syndrome Pharyngeal pouch syndrome disease_ontology DOID:11198 OMIM mapping confirmed by DO. [SN]. DiGeorge syndrome A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood. GARD:6733 ICD10CM:E20 ICD9CM:252.1 MESH:D007011 NCI:C78350 OMIM:146200 OMIM:307700 ORDO:2238 SNOMEDCT_US_2020_03_01:154697005 UMLS_CUI:C0020626 disease_ontology DOID:11199 Xref MGI. hypoparathyroidism MESH:D007011 DOID:111 DOID:13536 DOID:14031 GARD:6384 ICD10CM:I85.01 ICD9CM:456.0 ICD9CM:456.2 ICD9CM:456.20 NCI:C78282 SNOMEDCT_US_2020_03_01:195475003 SNOMEDCT_US_2020_03_01:195643006 SNOMEDCT_US_2020_03_01:236067006 UMLS_CUI:C0155789 UMLS_CUI:C0155791 UMLS_CUI:C0155792 Bleeding esophageal varices Bleeding oesophageal varices esophageal varices esophageal varices in disease classified elsewhere, with bleeding esophageal varices with bleeding esophageal varices with bleeding in disease EC esophageal varices without bleeding esophageal varices without mention of bleeding disease_ontology DOID:112 esophageal varix A primary immunodeficiency disease that is characterized by decreased numbers of circulating or functioning T cells. DOID:613 NCI:C27145 NCI:C27872 SNOMEDCT_US_2020_03_01:402792003 UMLS_CUI:C1274233 UMLS_CUI:C1333147 T cell immunodeficiency T lymphocyte deficiency T lymphocyte immunodeficiency disease_ontology DOID:11200 T cell deficiency An endocrine system disease that is located_in the parathyroid gland. ICD10CM:E21.5 ICD9CM:252.9 MESH:D010279 NCI:C26844 SNOMEDCT_US_2020_03_01:73132005 UMLS_CUI:C0030517 disease of parathyroid glands disease_ontology DOID:11201 parathyroid gland disease A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant. MESH:D003233 NCI:C34506 SNOMEDCT_US_2020_03_01:231854006 UMLS_CUI:C0009766 disease_ontology DOID:11204 allergic conjunctivitis A substance abuse that involves the recurring use of opioid drugs despite negative consequences. ICD10CM:F11.1 ICD9CM:305.5 MESH:D009293 SNOMEDCT_US_2020_03_01:5602001 UMLS_CUI:C0029095 disease_ontology DOID:11206 opioid abuse A viral infectious disease that results in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis. ICD9CM:077.4 MESH:D003232 NCI:C34505 SNOMEDCT_US_2020_03_01:186677009 UMLS_CUI:C0009765 Apollo disease Epidemic hemorrhagic conjunctivitis disease_ontology viral conjunctivitis DOID:11227 acute hemorrhagic conjunctivitis ICD10CM:H05.0 ICD9CM:376.0 SNOMEDCT_US_2020_03_01:20551005 UMLS_CUI:C0155256 acute inflammation of orbit disease_ontology DOID:11230 acute orbital inflammation An acute orbital inflammation that is characterized by painful orbital mass and has_symptom eyelid edema, has_symptom erythema, has_symptom chemiosis, has_symptom proptosis, has_symptom blurred vision, has_symptom headache, has_symptom fever and has_symptom double vision. ICD10CM:H05.01 ICD9CM:376.01 MESH:D054517 NCI:C99000 SNOMEDCT_US_2020_03_01:194005002 UMLS_CUI:C0149507 disease_ontology DOID:11234 orbital cellulitis A intestinal cancer that is located_in the appendix. ICD10CM:C18.1 ICD9CM:153.5 MESH:D001063 NCI:C9333 SNOMEDCT_US_2020_03_01:93679002 UMLS_CUI:C0496779 cancer of the appendix malignant neoplasm of appendix vermiformis malignant tumor of appendix malignant tumor of the appendix disease_ontology DOID:11239 appendix cancer MESH:D001063 NCI:C4434 SNOMEDCT_US_2020_03_01:126846004 UMLS_CUI:C0003614 appendix neoplasm neoplasm of appendix disease_ontology DOID:11240 appendiceal neoplasm MESH:D000751 SNOMEDCT_US_2020_03_01:111468003 UMLS_CUI:C0002891 anaemia neonatal anemia neonatal neonatal anaemia disease_ontology DOID:11244 neonatal anemia ICD10CM:D65 ICD9CM:286.6 MESH:D004211 NCI:C2992 SNOMEDCT_US_2020_03_01:67406007 UMLS_CUI:C0012739 DIC Defibrination syndrome Diffuse or disseminated intravascular coagulation disease_ontology DOID:11247 disseminated intravascular coagulation A nutritional deficiency disease that is characterized by easy bleeding due to an inability to form blood clots caused by vitamin K deficiency, occurs most commonly in newborns, and has_material_basis_in deficiency of vitamin K secondary to liver prematurity, lack of vitamin K in a breastmillk diet, largely sterile gut, malabsorption, diarrhea, chronic illness, menorrhagia, chronic kidney disease, and some medications. ICD10CM:E56.1 ICD9CM:269.0 MESH:D014813 NCI:C99108 SNOMEDCT_US_2020_03_01:52675005 UMLS_CUI:C0042880 deficiency of vitamin K vitamin K deficiency vitamin K deficiency hemorrhagic disease disease_ontology DOID:11249 vitamin K deficiency bleeding A primary bacterial infectious disease that refers to a group of diseases, located in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted by lice, transmitted by fleas, and transmitted by mites. DOID:11255 DOID:12353 GARD:7833 ICD10CM:A75.0 ICD10CM:A75.2 ICD10CM:A75.9 ICD9CM:080 ICD9CM:081.0 ICD9CM:081.9 MESH:D014437 MESH:D014438 NCI:C84688 NCI:C84689 SNOMEDCT_US_2020_03_01:154375001 SNOMEDCT_US_2020_03_01:25668000 SNOMEDCT_US_2020_03_01:39111003 UMLS_CUI:C0041471 UMLS_CUI:C0041472 UMLS_CUI:C0041473 Endemic Typhus fever Exanthematic Typhus fever Flea typhus Louse-borne [epidemic] typhus Moscow typhus Murine [endemic] typhus Typhus fever endemic flea-borne typhus epidemic louse-borne typhus disease_ontology Classical typhus Epidemic (louse-borne) typhus Epidemic louse-borne typhus fever due to Rickettsia prowazekii European typhus Exanthematous typhus Famine fever Flea-borne rickettsiosis Flea-borne typhus Hospital fever Jail fever Louse-borne rickettsiosis Louse-borne typhus Mexican typhus Murine typhus Petechial fever Prison fever Rat flea typhus Ship fever Shop typhus Typhus exanthematique Urban typhus DOID:11256 typhus A bartonellosis that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain. ICD10CM:A28.1 ICD9CM:078.3 MESH:D002372 NCI:C84620 SNOMEDCT_US_2020_03_01:123319006 UMLS_CUI:C0007361 Debre's Syndrome Debre-Mollaret Syndrome Foshay-Mollaret Cat Scratch Fever benign lymphoreticulosis cat scratch fever disease_ontology DOID:11258 cat-scratch disease A viral infectious disease that results in inflammation located in brain or located in spinal cord, has_material_basis_in Rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. The infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis. GARD:7516 ICD10CM:A82 ICD9CM:071 MESH:D011818 NCI:C28182 SNOMEDCT_US_2020_03_01:14168008 UMLS_CUI:C0034494 Lyssa disease_ontology DOID:11260 rabies A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia. ICD10CM:A70 ICD9CM:073 MESH:D009956 NCI:C34873 SNOMEDCT_US_2020_03_01:154369005 UMLS_CUI:C0029291 psittacosis disease_ontology DOID:11262 ornithosis A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea. DOID:13013 DOID:13264 GARD:10374 ICD10CM:A71 ICD10CM:A71.0 ICD10CM:A71.1 ICD9CM:076 ICD9CM:076.0 ICD9CM:076.1 MESH:D014141 SNOMEDCT_US_2020_03_01:154367007 SNOMEDCT_US_2020_03_01:29976007 SNOMEDCT_US_2020_03_01:52812002 UMLS_CUI:C0040592 UMLS_CUI:C0153107 UMLS_CUI:C0153108 active stage trachoma trachoma dubium disease_ontology DOID:11265 trachoma A viral infectious disease that is a hemorrhagic fever, located in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade orthohantavirus has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure. ICD10CM:A98.5 ICD9CM:078.6 MESH:D006480 NCI:C84753 SNOMEDCT_US_2020_03_01:186701001 UMLS_CUI:C0019101 HFRS Hemorrhagic fever, Russian Hemorrhagic nephrosonephritis Puumala virus nephropathy disease_ontology DOID:11266 Hantavirus hemorrhagic fever with renal syndrome GARD:6825 ICD10CM:H18.44 ICD9CM:371.45 MESH:C536156 SNOMEDCT_US_2020_03_01:85149007 UMLS_CUI:C0152455 disease_ontology DOID:11267 keratomalacia ICD10CM:K04.5 ICD9CM:522.6 SNOMEDCT_US_2020_03_01:718052004 UMLS_CUI:C0392492 disease_ontology DOID:11269 chronic apical periodontitis ICD10CM:E05.2 ICD9CM:242.3 NCI:C35171 SNOMEDCT_US_2020_03_01:57777000 UMLS_CUI:C0342127 Plummer disease Toxic nodular Goiter Toxic nodular goiter disease_ontology DOID:11277 Plummer's disease MESH:D010899 NCI:C26853 SNOMEDCT_US_2020_03_01:237701005 UMLS_CUI:C0032001 Pituitary apoplexy disease_ontology DOID:1129 pituitary apoplexy A hemangioma that is characterized by a configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system. ICD10CM:I77.0 NCI:C2882 SNOMEDCT_US_2020_03_01:403966009 UMLS_CUI:C0334533 Arteriovenous hemangioma Cirsoid aneurysm Racemose Angioma Racemose aneurysm Racemose hemangioma disease_ontology DOID:11294 arteriovenous malformation NCI:C27117 SNOMEDCT_US_2020_03_01:95830009 UMLS_CUI:C0342405 Pituitary infarction disease_ontology DOID:1130 pituitary infarct A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has symptom skin reddening, has symptom skin itching, in the water or immediately after emerging and has symptom itchy, raised papules, occur within hours of infection. GARD:9747 ICD10CM:B65.3 ICD9CM:120.3 NCI:C34457 SNOMEDCT_US_2020_03_01:187115002 UMLS_CUI:C0546996 Cutaneous schistosomiasis Sea bather's eruption disease_ontology DOID:11302 cercarial dermatitis A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted by Haemaphysalis spinigera tick bite. The infection has symptom fever, has symptom headache, has symptom stiffness of the neck, has symptom severe muscle pain, has symptom cough, has symptom dehydration, and has symptom bleeding problems. GARD:8257 ICD10CM:A98.2 ICD9CM:065.2 MESH:D007733 SNOMEDCT_US_2020_03_01:23097003 UMLS_CUI:C0022810 disease_ontology DOID:11320 Kyasanur forest disease GARD:6370 ICD10CM:A46 ICD9CM:035 MESH:D004886 SNOMEDCT_US_2020_03_01:266005008 UMLS_CUI:C0014733 disease_ontology DOID:11330 erysipelas A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs. GARD:7607 ICD10CM:D86 ICD9CM:135 MESH:D012507 NCI:C34995 ORDO:797 SNOMEDCT_US_2020_03_01:154425004 UMLS_CUI:C0036202 Boeck sarcoid lymphogranulomatosis disease_ontology DOID:11335 sarcoidosis MESH:D012507 A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis. ICD9CM:040.1 MESH:D012226 SNOMEDCT_US_2020_03_01:72409005 UMLS_CUI:C0035468 disease_ontology DOID:11336 rhinoscleroma A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli. GARD:5144 ICD10CM:A35 ICD9CM:037 MESH:D013742 NCI:C85185 SNOMEDCT_US_2020_03_01:154312006 UMLS_CUI:C0039614 Infection due to Clostridium tetani clostridial tetanus disease_ontology DOID:11338 tetanus An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever. GARD:4386 ICD10CM:B59 ICD9CM:136.3 MESH:D011020 NCI:C3334 SNOMEDCT_US_2020_03_01:57541005 UMLS_CUI:C1535939 Pneumocystis carinii pneumonia Pneumocystis jirovecii pneumonia Pneumocystis pneumonia Pneumocystosis Pneumocystosis pneumonia pulmonary pneumocystosis disease_ontology DOID:11339 pneumocystosis DOID:1133 DOID:13280 DOID:13901 DOID:2405 ICD10CM:K06.0 ICD10CM:K06.01 ICD9CM:523.2 ICD9CM:523.24 MESH:D005889 NCI:C82068 SNOMEDCT_US_2020_03_01:155645006 SNOMEDCT_US_2020_03_01:59898000 UMLS_CUI:C0017572 UMLS_CUI:C0266916 Gingival recession Gingival recession, localized localized gingival recession minimal gingival recession moderate gingival recession severe gingival recession disease_ontology DOID:1134 gingival recession An eye disease that affects the sclera, which is the white fibrous outer layer of the eyeball. ICD10CM:H15 MESH:D015422 NCI:C79717 SNOMEDCT_US_2020_03_01:33064008 UMLS_CUI:C0036412 disease_ontology DOID:11343 scleral disease ICD10CM:N32.3 ICD9CM:596.3 MESH:C562406 NCI:C160155 OMIM:109820 SNOMEDCT_US_2020_03_01:268335001 UMLS_CUI:C0156273 Diverticulum - bladder Diverticulum of bladder disease_ontology DOID:11353 OMIM mapping confirmed by DO. [SN]. bladder diverticulum A viral infectious disease that results in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted by Phlebotomus papatasi sandfly. The infection has symptom fever, has symptom severe frontal headaches, has symptom muscle ache, has symptom joint aches, has symptom flushing of the face, and has symptom tachycardia. ICD10CM:A93.1 ICD9CM:066.0 MESH:D010217 SNOMEDCT_US_2020_03_01:33670001 UMLS_CUI:C0030372 Sandfly fever Sandfly-borne arboviral fever Sandfly-borne bunyavirus fever Sandfly-borne phleboviral disease pappataci fever disease_ontology DOID:11360 Phlebotomus fever ICD10CM:H27.11 ICD9CM:379.32 MESH:D007906 NCI:C34772 SNOMEDCT_US_2020_03_01:155203002 UMLS_CUI:C0023316 Subluxation of lens disease_ontology DOID:11364 lens subluxation MESH:D007906 ICD10CM:Q12.3 ICD9CM:743.35 NCI:C35172 OMIM:610256 SNOMEDCT_US_2020_03_01:35387008 UMLS_CUI:C0152422 APHAKIA, CONGENITAL PRIMARY Congenital absence of lens disease_ontology DOID:11367 OMIM mapping confirmed by DO. [SN]. congenital aphakia A colonic disease that is characterized by an abnormal dilation of the colon. DOID:1771 ICD10CM:K59.39 MESH:D008531 NCI:C34810 SNOMEDCT_US_2020_03_01:33995003 UMLS_CUI:C0025160 Dilatation of colon disease_ontology DOID:11372 megacolon A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis. GARD:9286 ICD10CM:B83.1 ICD9CM:128.1 MESH:D058429 NCI:C128395 SNOMEDCT_US_2020_03_01:44086001 UMLS_CUI:C0018013 Gnathostomiasis Infectious Disease by Gnathostoma disease_ontology DOID:11379 gnathomiasis GARD:10264 MESH:D008579 NCI:C6935 SNOMEDCT_US_2020_03_01:189167009 UMLS_CUI:C0347515 Spinal Cord meningioma Spinal meningioma disease_ontology DOID:1138 spinal meningioma ICD10CM:Q53.9 ICD9CM:752.51 MESH:D003456 NCI:C12326 OMIM:219050 SNOMEDCT_US_2020_03_01:204879009 UMLS_CUI:C0010417 Cryptorchism Undescended testicle Undescended testis undescended testicles disease_ontology DOID:11383 OMIM mapping confirmed by DO. [SN]. cryptorchidism A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits. ICD10CM:F80.1 ICD9CM:315.31 NCI:C92562 SNOMEDCT_US_2020_03_01:80360005 UMLS_CUI:C0236826 Developmental expressive language disorder disease_ontology DOID:11385 expressive language disorder A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). MESH:D020802 SNOMEDCT_US_2020_03_01:310671007 UMLS_CUI:C0270629 abscess epidural disease_ontology DOID:11387 epidural abscess ICD9CM:437.4 SNOMEDCT_US_2020_03_01:28366008 UMLS_CUI:C0007773 Cerebral arteritis disease_ontology DOID:11390 cerebral arteritis A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. GARD:5698 ICD10CM:J80 MESH:D012128 NCI:C3353 SNOMEDCT_US_2020_03_01:155627006 UMLS_CUI:C0035222 ARDS Non-cardiogenic pulmonary edema Shock lung acute respiratory distress syndrome adult RDS disease_ontology DOID:11394 PRISM. adult respiratory distress syndrome A cardiovascular system disease that involves the heart. ICD10CM:I51.9 ICD9CM:429.9 MESH:D006331 NCI:C3079 SNOMEDCT_US_2020_03_01:194707003 UMLS_CUI:C0018799 disease_ontology DOID:114 heart disease NCI:C5134 UMLS_CUI:C1334264 disease_ontology DOID:1140 spinal canal and spinal cord meningioma ICD10CM:N16 ICD9CM:590.80 MESH:D011704 NCI:C34965 SNOMEDCT_US_2020_03_01:45816000 UMLS_CUI:C0034186 disease_ontology DOID:11400 pyelonephritis MESH:D011705 NCI:C123038 SNOMEDCT_US_2020_03_01:197777006 UMLS_CUI:C0034188 Xanthogranulomatous pyelonephritis disease_ontology DOID:11401 xanthogranulomatous pyelonephritis A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys. DOID:4132 GARD:1875 MESH:D003354 SNOMEDCT_US_2020_03_01:397434007 UMLS_CUI:C0010153 corynebacterium infection disease_ontology DOID:11405 diphtheria A female reproductive system disease characterized by the growth of fallopian tube-like epithelium outside the fallopian tube. NCI:C40121 SNOMEDCT_US_2020_03_01:55850004 UMLS_CUI:C0269106 disease_ontology DOID:11427 endosalpingiosis ICD10CM:H50.1 ICD9CM:378.1 MESH:D005099 NCI:C34601 SNOMEDCT_US_2020_03_01:155194007 UMLS_CUI:C0015310 Divergent Strabismus Divergent concomitant strabismus disease_ontology DOID:1143 exotropia A brain disease that is characterized by pressure on the intracranial tissues by an effusion of blood or cerebrospinal fluid, an abscess, a neoplasm, a depressed fracture of the skull, or edema of the brain. ICD10CM:G93.5 ICD9CM:348.4 SNOMEDCT_US_2020_03_01:46963008 UMLS_CUI:C0009592 disease_ontology DOID:11457 brain compression GARD:4561 ICD10CM:G93.2 ICD9CM:348.2 MESH:D011559 NCI:C85035 OMIM:243200 SNOMEDCT_US_2020_03_01:68267002 UMLS_CUI:C0033845 Pseudotumor cerebri benign intracran. hypt. benign intracranial hypertension idiopathic intracranial hypertension disease_ontology DOID:11459 OMIM mapping confirmed by DO. [SN]. pseudotumor cerebri ICD9CM:337.1 UMLS_CUI:C0154691 autonomic nervous system disorder disease_ontology DOID:11465 autonomic nervous system disease A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. EFO:0003882 ICD10CM:M81.0 ICD9CM:733.0 MESH:D010024 NCI:C3298 OMIM:166710 SNOMEDCT_US_2020_03_01:156825006 UMLS_CUI:C0029456 disease_ontology DOID:11476 Xref MGI. osteoporosis A physical disorder that is characterized by the presence of more than five fingers per hand or five toes per foot. DOID:14779 GARD:4410 ICD10CM:Q69 ICD9CM:755.0 MESH:C562429 MESH:D017689 NCI:C87110 OMIM:174200 OMIM:174500 OMIM:174700 OMIM:603596 SNOMEDCT_US_2020_03_01:205119005 UMLS_CUI:C0152427 UMLS_CUI:C0220697 postaxial polydactyly disease_ontology Supernumerary digit DOID:1148 polydactyly ICD9CM:423.2 MESH:D010494 NCI:C78246 SNOMEDCT_US_2020_03_01:155340008 UMLS_CUI:C0031048 Constrictive pericarditis disease_ontology DOID:11481 constrictive pericarditis A pericardial effusion that results from blood in the pericardial sac. ICD9CM:423.0 MESH:D010490 NCI:C111644 SNOMEDCT_US_2020_03_01:155339006 UMLS_CUI:C0019064 Haemopericardium disease_ontology DOID:11482 hemopericardium GARD:6670 ICD10CM:G90.2 MESH:D006732 NCI:C28155 OMIM:143000 SNOMEDCT_US_2020_03_01:192922002 UMLS_CUI:C0019937 Bernard Horner syndrome Horner syndrome cervical sympathetic paralysis disease_ontology DOID:11486 Horner's syndrome A pericardial effusion in which fluid accumulates in the pericardium (the sac in which the heart is enclosed) and the pericardial spaces fills up faster than the pericardial sac can stretch. ICD10CM:I31.4 ICD9CM:423.3 MESH:D002305 NCI:C50481 SNOMEDCT_US_2020_03_01:266295005 UMLS_CUI:C0007177 Rose's tamponade pericardial tamponade disease_ontology DOID:115 cardiac tamponade DOID:11737 DOID:13947 ICD10CM:Q23.3 ICD9CM:396.3 ICD9CM:746.6 MESH:D008944 NCI:C50888 SNOMEDCT_US_2020_03_01:194736003 SNOMEDCT_US_2020_03_01:194977007 SNOMEDCT_US_2020_03_01:29928006 UMLS_CUI:C0026266 UMLS_CUI:C0158619 UMLS_CUI:C0264774 Congenital insufficiency of mitral valve Mitral valve incompetence congenital mitral insufficiency congenital mitral regurgitation mitral regurgitation disease_ontology DOID:11502 mitral valve insufficiency NCI:C27033 SNOMEDCT_US_2020_03_01:277879009 UMLS_CUI:C0259749 disease_ontology DOID:11504 autonomic neuropathy A otitis media which involves inflammation of the middle ear with infected effusion containing pus. ICD10CM:H66.4 ICD9CM:382.4 MESH:D010035 SNOMEDCT_US_2020_03_01:267758003 UMLS_CUI:C0029888 Otitis media with effusion - purulent Purulent otitis media disease_ontology DOID:11506 suppurative otitis media ICD10CM:I82.0 MESH:D006502 OMIM:600880 SNOMEDCT_US_2020_03_01:195436007 UMLS_CUI:C0019154 hepatic vein thrombosis disease_ontology DOID:11512 Budd-Chiari syndrome ICD10CM:K14.5 ICD9CM:529.5 MESH:D014063 OMIM:137400 SNOMEDCT_US_2020_03_01:52368004 UMLS_CUI:C0040412 Congenital fissure of tongue Congenital plicated tongue Fissure of tongue Fissure of tongue, congenital Furrowed tongue Plicated tongue Tongue, Fissured geographic tongue and fissured tongue lingua plicata scrotal tongue disease_ontology DOID:11514 OMIM mapping confirmed by DO. [SN]. fissured tongue A heart disease that is caused by high blood pressure. ICD10CM:I11 ICD9CM:402 NCI:C157879 SNOMEDCT_US_2020_03_01:155297007 UMLS_CUI:C0152105 disease_ontology DOID:11516 hypertensive heart disease ICD10CM:J38.6 ICD9CM:478.74 MESH:D007829 NCI:C79608 SNOMEDCT_US_2020_03_01:195864007 UMLS_CUI:C0023075 Stenosis of larynx disease_ontology DOID:11527 laryngostenosis ICD10CM:H18.83 ICD9CM:371.42 SNOMEDCT_US_2020_03_01:2055003 UMLS_CUI:C0155119 recurrent erosion of cornea recurrent erosion syndrome disease_ontology DOID:11541 recurrent corneal erosion ICD10CM:H16.31 ICD9CM:370.55 NCI:C26969 SNOMEDCT_US_2020_03_01:64366002 UMLS_CUI:C0155091 disease_ontology DOID:11543 corneal abscess A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision. EFO:0003946 GARD:10018 ICD10CM:H18.51 MESH:D005642 NCI:C84721 OMIM:136800 OMIM:610158 OMIM:613267 OMIM:613268 OMIM:613269 OMIM:613270 OMIM:613271 OMIM:615523 ORDO:98974 SNOMEDCT_US_2020_03_01:16949007 UMLS_CUI:C0016781 FCED Fuchs' corneal dystrophy Fuchs' endothelial corneal dystrophy disease_ontology DOID:11555 Xref MGI. Fuchs' endothelial dystrophy An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint. DOID:11303 DOID:1155 DOID:12090 DOID:12102 DOID:12945 DOID:13298 DOID:13299 DOID:13301 DOID:13302 DOID:13303 DOID:13304 DOID:14143 DOID:14220 DOID:14513 DOID:1834 DOID:1945 DOID:2486 ICD9CM:712.1 NCI:C34955 OMIM:118600 OMIM:118610 OMIM:600668 ORDO:1416 SNOMEDCT_US_2020_03_01:201624004 SNOMEDCT_US_2020_03_01:201625003 UMLS_CUI:C0033802 UMLS_CUI:C0157852 calcium pyrophosphate deposition disease pseudogout disease_ontology DOID:1156 Xref MGI. chondrocalcinosis ICD10CM:H35.03 ICD9CM:362.11 MESH:D058437 NCI:C3514 SNOMEDCT_US_2020_03_01:422001004 UMLS_CUI:C0152132 disease_ontology DOID:11561 hypertensive retinopathy A somatoform disorder that involves heart disease symptoms without any identifiable physiological abnormatlities. ICD9CM:306.2 MESH:D009449 SNOMEDCT_US_2020_03_01:46219009 UMLS_CUI:C0027821 Cardiovascular malfunction arising from mental factors Cardiovascular neurosis Da Costa's syndrome Krishaber's disease disease_ontology DOID:11569 neurocirculatory asthenia A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth. ICD10CM:A32 ICD9CM:027.0 MESH:D008088 NCI:C82994 SNOMEDCT_US_2020_03_01:186315001 UMLS_CUI:C0023860 Infection by Listeria monocytogenes Listeria infection disease_ontology DOID:11573 listeriosis A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord. GARD:10987 ICD10CM:G83.4 ICD9CM:344.6 MESH:D000077684 NCI:C35436 SNOMEDCT_US_2020_03_01:89356000 UMLS_CUI:C0392548 disease_ontology DOID:11577 Cauda equina syndrome ICD10CM:H16.25 ICD9CM:370.31 SNOMEDCT_US_2020_03_01:193773009 UMLS_CUI:C0155080 Phlyctenular keratoconjunctivitis Strumous ophthalmia disease_ontology DOID:11581 phlyctenulosis ICD10CM:G90.1 MESH:D004402 NCI:C84706 OMIM:223900 SNOMEDCT_US_2020_03_01:204087006 UMLS_CUI:C0013364 HSAN III familial autonomic nervous dysfunction familial dysautonomia disease_ontology DOID:11589 OMIM mapping confirmed by DO. [SN]. Riley-Day syndrome ICD9CM:536.8 UMLS_CUI:C0013396 disease_ontology DOID:1159 functional gastric disease ICD10CM:H15.84 ICD9CM:379.11 SNOMEDCT_US_2020_03_01:111534007 UMLS_CUI:C0155359 Scleral ectasia disease_ontology DOID:11595 scleral staphyloma GARD:6467 MESH:D013547 OMIM:144100 SNOMEDCT_US_2020_03_01:56046002 UMLS_CUI:C0038994 Baillarger syndrome gustatory hyperhidrosis gustatory sweating disease_ontology DOID:11599 OMIM mapping confirmed by DO. [SN]. Frey syndrome DOID:5780 ICD10CM:C38.0 NCI:C4567 NCI:C4651 SNOMEDCT_US_2020_03_01:126734005 SNOMEDCT_US_2020_03_01:93957005 UMLS_CUI:C0346609 UMLS_CUI:C0349574 Pericardial tumor malignant neoplasm of pericardium malignant tumor of Pericardium disease_ontology DOID:116 pericardium cancer A meningitis that has_material_basis_in a fungal infection. MESH:D016921 SNOMEDCT_US_2020_03_01:24321005 UMLS_CUI:C0085438 disease_ontology DOID:11608 fungal meningitis An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. EFO:0000660 ICD10CM:E28.2 ICD9CM:256.4 MESH:D011085 NCI:C26862 OMIM:184700 SNOMEDCT_US_2020_03_01:69878008 UMLS_CUI:C0032460 Multicystic ovaries PCOS Polycystic Ovarian disease Polycystic ovaries Polycystic ovary syndrome Stein-Leventhal synd. Stein-Leventhal syndrome polycystic ovary disease_ontology DOID:11612 OMIM mapping confirmed by DO. [SN]. polycystic ovary syndrome MESH:D017588 SNOMEDCT_US_2020_03_01:237793004 UMLS_CUI:C0206081 hyperandrogenization syndrome disease_ontology DOID:11613 hyperandrogenism DOID:11614 ICD10CM:C60 ICD10CM:C60.2 ICD9CM:187.3 ICD9CM:187.4 MESH:D010412 NCI:C7547 SNOMEDCT_US_2020_03_01:93716006 SNOMEDCT_US_2020_03_01:93954003 UMLS_CUI:C0153600 UMLS_CUI:C0153601 Ca penis Penile Ca malignant Penile tumor malignant neoplasm of body of penis penile neoplasm disease_ontology DOID:11615 penile cancer ICD10CM:K04.1 ICD9CM:522.1 MESH:D003790 SNOMEDCT_US_2020_03_01:196332000 UMLS_CUI:C0011407 necrosis of the pulp necrotic pulp pulp necrosis disease_ontology DOID:11623 dental pulp necrosis MESH:D010412 NCI:C3317 SNOMEDCT_US_2020_03_01:126896003 UMLS_CUI:C0030849 Penile tumor neoplasm of penis disease_ontology DOID:11624 penile benign neoplasm MESH:D018382 NCI:C85191 OMIM:188570 OMIM:274300 SNOMEDCT_US_2020_03_01:50375007 UMLS_CUI:C2940786 Generalized thyroid hormone resistance Refetoff syndrome Thyroid hormone resistance syndrome Thyroid hormone responsiveness defect thyroid hormone resistance disease_ontology DOID:11633 OMIM mapping confirmed by DO. [LS]. thyroid hormone resistance syndrome ICD10CM:H52.4 ICD9CM:367.4 MESH:D011305 SNOMEDCT_US_2020_03_01:155135005 UMLS_CUI:C0033075 disease_ontology DOID:11638 presbyopia A bullous skin disease characterized by skin lesions and scaring and located_in mucous membranes and located_in skin. DOID:11655 GARD:5913 ICD10CM:L12.1 ICD9CM:694.6 ICD9CM:694.61 MESH:D010390 NCI:C34907 OMIM:164185 SNOMEDCT_US_2020_03_01:34250006 SNOMEDCT_US_2020_03_01:76092003 UMLS_CUI:C0030804 UMLS_CUI:C0157721 Cicatricial pemphigoid with ocular involvement Ocular pemphigoid benign mucous membrane pemphigoid benign mucous membrane pemphigoid with ocular involvement ocular pemphigus disease_ontology DOID:11656 cicatricial pemphigoid An arthritis that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms. DOID:1165 DOID:1177 DOID:1178 DOID:1179 DOID:12951 DOID:13354 DOID:13355 DOID:13771 GARD:7304 ICD10CM:M12.3 ICD9CM:719.3 ICD9CM:719.31 MESH:C538103 SNOMEDCT_US_2020_03_01:202455001 SNOMEDCT_US_2020_03_01:202457009 UMLS_CUI:C0085574 UMLS_CUI:C0158178 Hench's syndrome Hench-Rosenberg syndrome disease_ontology DOID:1166 palindromic rheumatism A color blindness that is characterised by a selective deficiency of blue vision, has_material_basis_in autosomal dominant inheritance of a mutation in the OPN1SW gene and is associated with a deficiency or absence of blue-sensitive cone photoreceptor function. ICD10CM:H53.55 ICD9CM:368.53 MESH:D003117 OMIM:190900 SNOMEDCT_US_2020_03_01:51886007 UMLS_CUI:C0155017 Tritan defect Tritanopia disease_ontology DOID:11661 OMIM mapping confirmed by DO. [SN]. blue color blindness ICD10CM:Q91.7 ICD9CM:758.1 MESH:D000073839 NCI:C101223 SNOMEDCT_US_2020_03_01:21111006 UMLS_CUI:C0152095 D1 Trisomy trisomy 13 disease_ontology Patau's syndrome DOID:11665 OMIM mapping confirmed by DO. [LS]. Patau syndrome A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. GARD:7252 ICD10CM:B73 ICD9CM:125.3 MESH:D009855 NCI:C34861 SNOMEDCT_US_2020_03_01:38539003 UMLS_CUI:C0029001 Infection by Onchocerca volvulus Onchocerca volvulus infection volvulosis disease_ontology DOID:11678 onchocerciasis DOID:3147 ICD10CM:E78.5 MESH:D006949 MESH:D006951 NCI:C34707 NCI:C34709 SNOMEDCT_US_2020_03_01:154739000 SNOMEDCT_US_2020_03_01:3744001 UMLS_CUI:C0020473 UMLS_CUI:C0020476 familial hyperlipoproteinemia hyperlipemia disease_ontology hyperlipidaemia DOID:1168 familial hyperlipidemia NCI:C27548 SNOMEDCT_US_2020_03_01:201096007 UMLS_CUI:C1321683 disease_ontology DOID:11684 melanoacanthoma ICD10CM:K04.4 ICD9CM:522.4 SNOMEDCT_US_2020_03_01:88071000 UMLS_CUI:C0155934 acute apical periodontitis of pulpal origin disease_ontology DOID:11693 acute apical periodontitis A hepatic vascular disease that is characterized by a blood clot that forms within the hepatic portal vein. ICD10CM:I81 ICD9CM:452 NCI:C78565 SNOMEDCT_US_2020_03_01:155455003 UMLS_CUI:C0155773 disease_ontology DOID:11695 portal vein thrombosis A cardiovascular cancer located_in the heart. DOID:9918 GARD:2619 ICD10CM:C38.0 ICD9CM:164.1 MESH:D006338 NCI:C3081 NCI:C3548 SNOMEDCT_US_2020_03_01:126730001 SNOMEDCT_US_2020_03_01:93825008 UMLS_CUI:C0018809 UMLS_CUI:C0153500 Cardiac tumor Tumour of heart malignant Cardiac tumor malignant neoplasm of heart disease_ontology DOID:117 heart cancer A selective immunoglobulin deficiency disease that is caused by a reduction in some types of gamma globulins. MESH:D004406 SNOMEDCT_US_2020_03_01:127389001 UMLS_CUI:C0013374 Dysgammaglobulinemia disease_ontology DOID:11702 dysgammaglobulinemia MESH:D004406 A peripheral vascular disease that is characterized by narrowing of the arteries as a complication arising from chronic diabetes. DOID:10182 ICD9CM:250.7 MESH:D003925 NCI:C35610 SNOMEDCT_US_2020_03_01:127014009 UMLS_CUI:C0011871 UMLS_CUI:C0011875 Diabetic vascular disorder diabetic peripheral angiopathy disease_ontology DOID:11713 diabetic angiopathy A diabetes mellitus that manifests during pregnancy. EFO:0004593 ICD10CM:O24.4 MESH:D016640 NCI:C34942 SNOMEDCT_US_2020_03_01:11687002 UMLS_CUI:C0085207 GDM Gestational diabetes mellitus Maternal gestational diabetes mellitus disease_ontology DOID:11714 gestational diabetes A glucose metabolism disease that is characterized by blood glucose levels are high, but not high enough to be classified as type 2 diabetes. ICD10CM:R73.03 MESH:D011236 NCI:C122685 SNOMEDCT_US_2020_03_01:15777000 UMLS_CUI:C0362046 Prediabetes impaired glucose tolerance prediabetic state disease_ontology DOID:11716 prediabetes syndrome A diabetes mellitus that is characterized by hyperglycemia occuring within the first 6 months of life. ICD10CM:P70.2 ICD9CM:775.1 NCI:C99248 SNOMEDCT_US_2020_03_01:49817004 UMLS_CUI:C0158981 diabetes mellitus syndrome in newborn infant neonatal diabetes mellitus disease_ontology DOID:11717 neonatal diabetes DOID:0050527 ICD10CM:E78.1 ICD9CM:272.1 MESH:D006953 NCI:C34711 OMIM:144600 OMIM:145750 SNOMEDCT_US_2020_03_01:154741004 UMLS_CUI:C0020480 Endogenous hyperlipidaemia Fredrickson type IV Lipidemia Fredrickson type IV hyperlipoproteinemia Fredrickson type IV lipidaemia VLDL hyperlipoproteinemia familial hypertriglyceridemia disease_ontology DOID:1172 OMIM mapping confirmed by DO. [SN]. hyperlipoproteinemia type IV A muscular dystrophy that is characterized by predominant weakness and atrophy beginning in the feet and/or hands. ICD10CM:G71.09 MESH:D049310 NCI:C84675 ORDO:399096 ORDO:5448 ORDO:59135 SNOMEDCT_US_2020_03_01:58795000 UMLS_CUI:C0751336 Miyoshi muscular dystrophy distal muscular dystrophy disease_ontology DOID:11720 Xref MGI. OMIM mapping confirmed by DO. [SN]. distal myopathy A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_material_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region. GARD:8310 ICD10CM:G71.11 ICD9CM:359.21 MESH:D009223 NCI:C84914 OMIM:160900 SNOMEDCT_US_2020_03_01:77956009 UMLS_CUI:C0027126 Dystrophia myotonica Steinert disease congenital myotonic dystrophy myotonic dystrophy of Steinert disease_ontology DOID:11722 OMIM mapping confirmed by DO. [SN]. myotonic dystrophy type 1 MESH:C535686 A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy. GARD:6291 MESH:D020388 NCI:C75482 OMIM:310200 SNOMEDCT_US_2020_03_01:155095006 UMLS_CUI:C0013264 Muscular dystrophy, Duchenne disease_ontology DOID:11723 OMIM mapping confirmed by DO. [SN]. Duchenne muscular dystrophy A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles. GARD:6907 ICD10CM:G71.09 MESH:D049288 NCI:C84828 ORDO:263 SNOMEDCT_US_2020_03_01:56096001 UMLS_CUI:C0686353 Erb's muscular dystrophy Leyden-Mbius muscular dystrophy limb girdle muscular dystrophy disease_ontology DOID:11724 Xref MGI. OMIM mapping confirmed by DO. [SN]. limb-girdle muscular dystrophy A syndrome that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features. GARD:10109 ICD10CM:Q87.19 MESH:D003635 NCI:C75016 OMIM:PS122470 ORDO:199 SNOMEDCT_US_2020_03_01:40354009 UMLS_CUI:C0270972 Brachmann de Lange syndrome De Lange syndrome disease_ontology DOID:11725 Xref MGI. OMIM mapping confirmed by DO. [SN]. Cornelia de Lange syndrome A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle. GARD:6329 MESH:D020389 NCI:C84685 OMIM:PS310300 ORDO:261 SNOMEDCT_US_2020_03_01:129620000 UMLS_CUI:C0410189 EDMD disease_ontology DOID:11726 Xref MGI. OMIM mapping confirmed by DO. [SN]. Emery-Dreifuss muscular dystrophy GARD:9941 ICD10CM:G71.02 MESH:D020391 NCI:C84704 SNOMEDCT_US_2020_03_01:56096001 UMLS_CUI:C0238288 Landouzy Dejerine muscular dystrophy Landouzy-Dejerine muscular dystrophy Muscular dystrophy, Landouzy-Dejerine disease_ontology DOID:11727 OMIM mapping confirmed by DO. [SN]. facioscapulohumeral muscular dystrophy A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. DOID:12233 GARD:12073 ICD10CM:A69.2 ICD9CM:088.81 MESH:D008193 MESH:D020852 NCI:C45161 SNOMEDCT_US_2020_03_01:154376000 SNOMEDCT_US_2020_03_01:715507005 UMLS_CUI:C0024198 UMLS_CUI:C0752235 Bannwarth syndrome Bannworth's syndrome Lyme borreliosis Neurological Lyme disease lyme neuroboInOwlrreliosis neuroboInOwlrreliosis disease_ontology DOID:11729 Lyme disease MESH:D042883 SNOMEDCT_US_2020_03_01:197397004 UMLS_CUI:C0701818 disease_ontology DOID:11755 choledocholithiasis ICD10CM:D50 MESH:D000747 NCI:C34380 SNOMEDCT_US_2020_03_01:44452003 UMLS_CUI:C0002884 ANEMIA HYPOCHROMIC disease_ontology DOID:11759 hypochromic anemia A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. DOID:1175 DOID:12322 MESH:D001982 SNOMEDCT_US_2020_03_01:41427001 UMLS_CUI:C0006261 Bronchospasm disease_ontology DOID:1176 bronchial disease ICD10CM:H55.03 ICD9CM:379.53 MESH:D009759 SNOMEDCT_US_2020_03_01:39771000 UMLS_CUI:C0271384 Ocular nystagmus Searching eye movements visual deprivation nystagmus disease_ontology DOID:11771 spontaneous ocular nystagmus ICD10CM:H44.53 ICD9CM:360.44 SNOMEDCT_US_2020_03_01:193288000 UMLS_CUI:C0152458 Leucocoria disease_ontology DOID:11772 leukocoria ICD10CM:H52.22 ICD9CM:367.21 SNOMEDCT_US_2020_03_01:68905002 UMLS_CUI:C0152193 disease_ontology DOID:11781 regular astigmatism A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision. EFO:0004222 ICD10CM:H52.2 ICD9CM:367.2 MESH:D001251 OMIM:603047 SNOMEDCT_US_2020_03_01:155134009 UMLS_CUI:C0004106 disease_ontology DOID:11782 OMIM mapping confirmed by DO. [SN]. astigmatism ICD9CM:289.52 UMLS_CUI:C1260402 disease_ontology DOID:11786 splenic sequestration A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity. MESH:D010490 NCI:C3319 SNOMEDCT_US_2020_03_01:70370001 UMLS_CUI:C0031039 disease_ontology DOID:118 pericardial effusion A nutritional deficiency disease that is characterized by inadequate dietary protein and calories, which can have profound systemic effects including decreased metabolism, altered tissue distribution, compromised immunity, and impaired growth, and has_material_basis_in dietary deprivation. ICD10CM:E46 ICD9CM:263.9 MESH:D011502 NCI:C34952 SNOMEDCT_US_2020_03_01:72608005 UMLS_CUI:C0033677 disease_ontology DOID:11801 protein-energy malnutrition ICD10CM:H43.81 ICD9CM:379.21 SNOMEDCT_US_2020_03_01:60189009 UMLS_CUI:C0155366 Vitreous degeneration disease_ontology DOID:11816 vitreous syneresis A urinary system cancer that is located_in the ureter. ICD10CM:C66 ICD9CM:189.2 MESH:D014516 NCI:C7543 OMIM:191600 SNOMEDCT_US_2020_03_01:94121005 UMLS_CUI:C0153619 malignant tumour of ureter malignant ureteral tumor disease_ontology DOID:11819 OMIM mapping confirmed by DO. [SN]. ureter cancer A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis. GARD:7103 ICD10CM:E78.81 NCI:C27896 ORDO:139436 SNOMEDCT_US_2020_03_01:84241008 UMLS_CUI:C0311284 Lipoid dermatoarthritis Multicentric reticulohistiocytosis disease_ontology DOID:11824 multicentric reticulohistiocytosis A refractive error characterized by the inability to see farther objects clearly. EFO:0003927 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 SNOMEDCT_US_2020_03_01:155133003 UMLS_CUI:C0027092 near vision near-sightedness short-sightedness disease_ontology DOID:11830 Xref MGI. myopia MESH:D009216 ICD10CM:H47.61 ICD9CM:377.75 MESH:D019575 NCI:C118707 SNOMEDCT_US_2020_03_01:68574006 UMLS_CUI:C0155320 disease_ontology DOID:11831 cortical blindness MESH:D012640 NCI:C3980 SNOMEDCT_US_2020_03_01:39194005 UMLS_CUI:C0270824 epilepsy, visual disease_ontology DOID:11832 visual epilepsy A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities. DOID:0001874 ICD10CM:Q66.89 ICD9CM:754.51 MESH:D003025 NCI:C84641 OMIM:119800 SNOMEDCT_US_2020_03_01:33163000 UMLS_CUI:C0009081 Congenital equinovarus Equinovarus deformity of foot congenital clubfoot congenital talipes equinovarus disease_ontology DOID:11836 OMIM mapping confirmed by DO. [SN]. clubfoot A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability. ICD10CM:N04 ICD9CM:581 MESH:D009404 NCI:C34845 SNOMEDCT_US_2020_03_01:155851004 UMLS_CUI:C0027726 disease_ontology DOID:1184 Xref MGI. nephrotic syndrome MESH:D003329 NCI:C34515 SNOMEDCT_US_2020_03_01:23687008 UMLS_CUI:C0010073 Coronary Vasospasm Coronary artery spasm disease_ontology DOID:11840 coronary artery vasospasm MESH:D020429 SNOMEDCT_US_2020_03_01:359842002 UMLS_CUI:C0751932 Posterior tibial neuropathy Tibial neuropathy disease_ontology DOID:1187 tibial neuropathy GARD:7392 ICD10CM:G31.01 ICD9CM:331.11 MESH:D020774 NCI:C85008 OMIM:172700 SNOMEDCT_US_2020_03_01:154998003 UMLS_CUI:C0236642 Dementia in Pick's disease LOBAR ATROPHY OF BRAIN PICK DISEASE OF BRAIN Pick disease disease_ontology DOID:11870 OMIM mapping confirmed by DO. [SN]. Pick's disease MESH:D020774 ICD10CM:K12.1 MESH:D013282 SNOMEDCT_US_2020_03_01:196576008 UMLS_CUI:C0038364 Denture sore mouth disease_ontology DOID:11875 denture stomatitis A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve. ICD10CM:G58.9 MESH:D020422 SNOMEDCT_US_2020_03_01:304595001 UMLS_CUI:C0494491 disease_ontology DOID:1188 mononeuropathy MESH:D014516 NCI:C3427 SNOMEDCT_US_2020_03_01:126882009 UMLS_CUI:C0041955 neoplasm of ureter ureteral tumor disease_ontology DOID:11885 ureteral benign neoplasm A female reproductive system cancer that is located_in the vagina. DOID:1902 GARD:9348 ICD10CM:C52 ICD9CM:184.0 MESH:D014625 NCI:C3437 NCI:C7410 SNOMEDCT_US_2020_03_01:126921000 SNOMEDCT_US_2020_03_01:188210000 UMLS_CUI:C0042237 UMLS_CUI:C0042258 malignant neoplasm of vagina malignant tumor of vagina malignant vaginal tumor neoplasm of vagina vagina neoplasm vaginal tumor disease_ontology DOID:119 vaginal cancer ICD10CM:K31.84 ICD9CM:536.3 MESH:D018589 NCI:C80512 SNOMEDCT_US_2020_03_01:235675006 UMLS_CUI:C0152020 Gastroparalysis Gastroparesis syndrome gastric atonia disease_ontology DOID:11914 gastroparesis A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze. ICD9CM:110.3 NCI:C34535 SNOMEDCT_US_2020_03_01:59089002 UMLS_CUI:C0011638 Dermatophytosis of Groin and Perianal Area Dermatophytosis of groin & perianal area Dermatophytosis of groin and perianal area Dhobie itch disease_ontology DOID:11917 tinea cruris A nervous system cancer that is located in the peripheral nervous system. DOID:3194 MESH:D010524 MESH:D018317 NCI:C3321 NCI:C4972 SNOMEDCT_US_2020_03_01:126980002 SNOMEDCT_US_2020_03_01:189946005 UMLS_CUI:C0031118 UMLS_CUI:C0206727 neoplasm of peripheral nerve nerve sheath neoplasm tumor of PNS disease_ontology DOID:1192 peripheral nervous system neoplasm A respiratory system cancer that is located_in the trachea. ICD10CM:C33 ICD9CM:162.0 NCI:C9346 SNOMEDCT_US_2020_03_01:187855003 UMLS_CUI:C0153489 disease_ontology DOID:11920 tracheal cancer An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx. GARD:12425 MESH:D006258 NCI:C3077 SNOMEDCT_US_2020_03_01:255055008 UMLS_CUI:C0018671 head and neck neoplasm head and neck tumours head/neck neoplasm tumor of head and neck disease_ontology DOID:11934 head and neck cancer EFO:0004226 GARD:6956 ICD10CM:A81.0 ICD9CM:046.1 MESH:D007562 NCI:C26802 OMIM:123400 SNOMEDCT_US_2020_03_01:155061007 UMLS_CUI:C0022336 CJD Creutzfeldt Jacob syndrome Creutzfeldt Jakob disease Creutzfeldt-Jacob disease Jakob-Creutzfeldt disease Subacute spongiform encephalopathy Transmissible virus dementia disease_ontology DOID:11949 OMIM mapping confirmed by DO. [SN]. Creutzfeldt-Jakob disease NCI:C27025 SNOMEDCT_US_2020_03_01:129611009 UMLS_CUI:C0238309 Ischemic peripheral neuropathy disease_ontology DOID:1195 ischemic neuropathy DOID:11962 ICD10CM:K20 ICD9CM:530.1 MESH:D004941 NCI:C9224 SNOMEDCT_US_2020_03_01:155673008 UMLS_CUI:C0014868 acute esophagitis disease_ontology DOID:11963 esophagitis A dysostosis that results_in abnormal fusing of adjacent bones. MESH:D013580 UMLS_CUI:C0039093 disease_ontology DOID:11971 synostosis A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. GARD:943 ICD10CM:A05.1 MESH:D001906 NCI:C84599 SNOMEDCT_US_2020_03_01:154276003 UMLS_CUI:C0006057 Botulism poisoning Food poisoning due to Clostridium botulinum Foodborne botulism Infection due to clostridium botulinum Intoxication with Clostridium botulinum toxin disease_ontology DOID:11976 botulism ICD9CM:278.01 MESH:D009767 NCI:C34858 SNOMEDCT_US_2020_03_01:389986000 UMLS_CUI:C0028756 Severe obesity disease_ontology DOID:11981 morbid obesity A chromosomal disease that is characterized by weak muscle tone, feeding difficulties, poor growth, and delayed development. Beginning in childhood, affected individuals develop an insatiable appetite, which leads to chronic overeating and obesity. GARD:5575 ICD10CM:Q87.11 ICD9CM:759.81 MESH:D011218 NCI:C75463 OMIM:176270 ORDO:739 SNOMEDCT_US_2020_03_01:205794007 UMLS_CUI:C0032897 Prader Willi syndrome disease_ontology DOID:11983 OMIM mapping confirmed by DO. [SN]. Prader-Willi syndrome An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause. DOID:11986 ICD9CM:425.1 KEGG:05410 MESH:D002312 MESH:D024741 NCI:C34449 NCI:C84773 ORDO:217568 SNOMEDCT_US_2020_03_01:389998005 SNOMEDCT_US_2020_03_01:83978005 UMLS_CUI:C0007194 UMLS_CUI:C0949658 familial hypertrophic cardiomyopathy hypertrophic obstructive cardiomyopathy disease_ontology DOID:11984 Xref MGI. OMIM mapping confirmed by DO. [SN]. hypertrophic cardiomyopathy An osteosclerosis that results_in numerous bone islands located_in skeleton. GARD:4158 ICD10CM:Q78.8 ICD9CM:756.53 MESH:D010023 NCI:C84985 SNOMEDCT_US_2020_03_01:9147009 UMLS_CUI:C0029455 disease_ontology DOID:11991 osteopoikilosis ICD10CM:N50.0 ICD9CM:608.3 NCI:C123259 SNOMEDCT_US_2020_03_01:155938008 UMLS_CUI:C0156312 disease_ontology DOID:11994 atrophy of testis ICD10CM:N44.02 ICD9CM:608.2 MESH:D013086 NCI:C26885 OMIM:187400 SNOMEDCT_US_2020_03_01:198046000 UMLS_CUI:C0037856 Torsion of testicle Torsion of testis testicular Torsion disease_ontology DOID:11996 spermatic cord torsion ICD10CM:N43.4 ICD9CM:608.1 MESH:D013088 NCI:C120909 SNOMEDCT_US_2020_03_01:155936007 UMLS_CUI:C0037859 disease_ontology DOID:11997 spermatocele A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva. DOID:1244 DOID:1281 ICD10CM:C57 ICD9CM:184 MESH:D005833 NCI:C3053 NCI:C4913 SNOMEDCT_US_2020_03_01:126907002 SNOMEDCT_US_2020_03_01:188207007 UMLS_CUI:C0017416 UMLS_CUI:C0153585 UMLS_CUI:C0699889 female reproductive cancer malignant Gynecologic tumor malignant neoplasm of female genital organ disease_ontology DOID:120 female reproductive organ cancer GARD:9790 ICD10CM:H47.01 ICD9CM:377.41 MESH:D018917 SNOMEDCT_US_2020_03_01:14357004 UMLS_CUI:C0155305 Ischemic optic neuropathy disease_ontology DOID:12010 anterior ischemic optic neuropathy An adrenal adenoma characterized by the over production of aldosterone. GARD:7456 ICD10CM:E26.01 ICD9CM:255.12 MESH:D006929 NCI:C34510 SNOMEDCT_US_2020_03_01:13536004 UMLS_CUI:C1384514 Conn syndrome primary aldosteronism primary hyperaldosteronism disease_ontology DOID:12028 Conn's syndrome ICD9CM:292.8 UMLS_CUI:C0154325 disease_ontology DOID:1203 drug-induced mental disorder An uveitis that is characterized by inflammation of all layers of the uvea (middle layer) of the eye, which includes the iris, ciliary body, and choroid. GARD:8577 ICD10CM:H44.11 ICD9CM:360.12 MESH:D015864 NCI:C84989 SNOMEDCT_US_2020_03_01:75614007 UMLS_CUI:C0030343 Diffuse uveitis disease_ontology DOID:12030 panuveitis An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods. allergic disease ICD10CM:T78.40 MESH:D006967 NCI:C3114 SNOMEDCT_US_2020_03_01:257550005 UMLS_CUI:C0020517 allergic hypersensitivity disease hypersensitivity hypersensitivity reaction type I disease disease_ontology DOID:1205 allergic disease An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii. GARD:6218 ICD10CM:B45 ICD9CM:117.5 MESH:D003453 NCI:C2967 SNOMEDCT_US_2020_03_01:42386007 UMLS_CUI:C0010414 Busse-Buschke's disease European cryptococcosis cryptococcal infection torula torulosis disease_ontology cryptococcus neoformans infection DOID:12053 cryptococcosis MESH:D003453 A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability. GARD:5696 ICD10CM:F84.2 MESH:D015518 NCI:C75488 OMIM:312750 OMIM:613454 SNOMEDCT_US_2020_03_01:192583003 UMLS_CUI:C0035372 Rett's disorder cerebroatrophic hyperammonemia disease_ontology DOID:1206 OMIM mapping confirmed by DO. [SN]. Rett syndrome GARD:7805 ICD10CM:G50.0 ICD9CM:350.1 MESH:D014277 OMIM:190400 SNOMEDCT_US_2020_03_01:155066002 UMLS_CUI:C0040997 Trifacial neuralgia Trigeminal neuralgia trifocal neuralgia disease_ontology DOID:12098 OMIM mapping confirmed by DO. [LS]. trigeminal neuralgia A female reproductive system disease that is located_in the vagina. MESH:D014623 NCI:C26910 SNOMEDCT_US_2020_03_01:25658005 UMLS_CUI:C0042251 disease_ontology DOID:121 vaginal disease An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision. GARD:7320 ICD10CM:H46 ICD9CM:377.3 MESH:D009902 NCI:C84950 SNOMEDCT_US_2020_03_01:194051001 UMLS_CUI:C0029134 disease_ontology DOID:1210 optic neuritis A lung disease that is characterized the accumulation of tiny fragments of calcium phosphate gradually accumulate in the alveoli of the lungs. GARD:11894 ICD10CM:J84.02 ICD9CM:516.2 MESH:C562405 OMIM:265100 SNOMEDCT_US_2020_03_01:196160008 UMLS_CUI:C0155912 disease_ontology DOID:12117 OMIM mapping confirmed by DO. [SN]. pulmonary alveolar microlithiasis An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload. GARD:6595 MESH:D006486 NCI:C82892 SNOMEDCT_US_2020_03_01:39011001 UMLS_CUI:C0019114 haemosiderosis disease_ontology DOID:12119 hemosiderosis A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange. ICD10CM:J84.01 ICD9CM:516.0 MESH:D011649 NCI:C85037 OMIM:265120 OMIM:300770 OMIM:610913 OMIM:610921 OMIM:614370 ORDO:264675 SNOMEDCT_US_2020_03_01:10501004 UMLS_CUI:C0034050 disease_ontology DOID:12120 Xref MGI. pulmonary alveolar proteinosis An autoimmune disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera, and is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels. GARD:7880 ICD10CM:M31.3 ICD9CM:446.4 MESH:D014890 NCI:C3444 OMIM:608710 SNOMEDCT_US_2020_03_01:195353004 UMLS_CUI:C3495801 Necrotizing respiratory granulomatosis Wegener granulomatosis, formerly disease_ontology DOID:12132 granulomatosis with polyangiitis A blood coagulation disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. GARD:6591 ICD10CM:D66 ICD9CM:286.0 MESH:D006467 NCI:C27146 OMIM:306700 ORDO:98878 SNOMEDCT_US_2020_03_01:28293008 UMLS_CUI:C0019069 Congenital factor VIII disorder Hemophilia A Subhemophilia classic hemophilia A disease_ontology DOID:12134 OMIM mapping confirmed by DO. [SN]. factor VIII deficiency MESH:D006467 A mood disorder that involves the presence of a low mood almost daily over a span of at least two years. ICD10CM:F34.1 ICD9CM:300.4 MESH:D019263 NCI:C34562 SNOMEDCT_US_2020_03_01:192384008 UMLS_CUI:C0013415 dysthymia disease_ontology DOID:12139 dysthymic disorder A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis. DOID:0050016 DOID:0050019 DOID:0050020 GARD:6030 ICD9CM:086.2 KEGG:05142 SNOMEDCT_US_2020_03_01:186817003 UMLS_CUI:C0007932 Chagas' disease chagas' disease with digestive system involvement chagas' disease with nervous system involvement chagas' disease with other organ involvement disease_ontology American trypanosomiasis DOID:12140 Chagas disease ICD9CM:596.54 MESH:D001750 NCI:C79696 SNOMEDCT_US_2020_03_01:192972000 UMLS_CUI:C0005697 Neuropathic bladder neurogenic dysfunction of the urinary bladder neurogenic urinary bladder disorder disease_ontology DOID:12143 neurogenic bladder ICD9CM:596.52 SNOMEDCT_US_2020_03_01:9009001 UMLS_CUI:C0489967 Low bladder compliance hyperactivity of bladder hypertonic bladder hypertonicity of bladder disease_ontology DOID:12144 low compliance bladder ICD9CM:596.55 SNOMEDCT_US_2020_03_01:236655005 UMLS_CUI:C0341747 disease_ontology DOID:12145 detrusor sphincter dyssynergia A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting. DOID:10662 ICD10CM:A87.2 MESH:D008216 SNOMEDCT_US_2020_03_01:192668002 UMLS_CUI:C0024266 LCM Lymphocytic choriomeningitis virus encephalomyelitis Lymphocytic meningitis Lymphocytic meningoencephalitis disease_ontology DOID:12155 lymphocytic choriomeningitis ICD10CM:H35.4 ICD9CM:362.6 NCI:C34919 SNOMEDCT_US_2020_03_01:193393004 UMLS_CUI:C1320640 peripheral degeneration of retina disease_ontology DOID:12161 peripheral retinal degeneration ICD10CM:G56.2 ICD9CM:354.2 SNOMEDCT_US_2020_03_01:55802003 UMLS_CUI:C1288279 Lesion of ulnar nerve disease_ontology DOID:12168 ulnar nerve lesion ICD10CM:G56.0 ICD9CM:354.0 MESH:D002349 NCI:C34450 OMIM:115430 SNOMEDCT_US_2020_03_01:193126005 UMLS_CUI:C0007286 CTS - Carpal tunnel syndrome Carpal tunnel syndrome Median nerve entrapment carpal tunnel median neuropathy disease_ontology DOID:12169 OMIM mapping confirmed by DO. [SN]. carpal tunnel syndrome ICD10CM:E07.1 ICD9CM:246.1 SNOMEDCT_US_2020_03_01:190304001 UMLS_CUI:C0152077 Dyshormonogenic goiter Dyshormonogenic goitre dyshormonogenic goitre disease_ontology DOID:12175 dyshormonogenic goiter A thyroid gland disease that involves an abnormal enlargement of the thyroid gland. ICD10CM:E04.9 ICD9CM:240.9 MESH:D006042 NCI:C26785 SNOMEDCT_US_2020_03_01:237568003 UMLS_CUI:C0018021 goitre disease_ontology DOID:12176 goiter MESH:D006042 An agammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. GARD:6140 ICD10CM:D83 ICD9CM:279.06 MESH:D017074 OMIM:240500 OMIM:607594 OMIM:613493 OMIM:613494 OMIM:613495 OMIM:613496 OMIM:614699 OMIM:614700 OMIM:615577 OMIM:615767 ORDO:1572 SNOMEDCT_US_2020_03_01:191010004 UMLS_CUI:C0009447 CVID acquired agammaglobulinemia acquired hypogammaglobulinemia common variable agammaglobulinemia sporadic hypogammaglobulinemia disease_ontology DOID:12177 Xref MGI. OMIM mapping confirmed by DO. [SN]. common variable immunodeficiency An otitis interna characterized by an abnormal bone growth in the middle ear. EFO:0004213 ICD10CM:H80.80 ICD9CM:387.8 OMIM:166800 OMIM:605727 OMIM:608244 OMIM:608484 OMIM:611571 OMIM:611572 OMIM:612096 OMIM:615589 ORDO:2794 SNOMEDCT_US_2020_03_01:194382008 UMLS_CUI:C0029696 disease_ontology DOID:12185 Xref MGI. otosclerosis MESH:D010040 ICD10CM:C18.7 ICD9CM:153.3 MESH:D012811 SNOMEDCT_US_2020_03_01:94006002 UMLS_CUI:C0153436 Ca sigmoid colon malignant tumor of sigmoid colon disease_ontology DOID:12192 sigmoid colon cancer ICD10CM:H16.14 ICD9CM:370.21 SNOMEDCT_US_2020_03_01:193767008 UMLS_CUI:C0259799 Punctate keratitis Thygeson superficial punctate keratitis Thygeson's superficial punctate keratitis disease_ontology DOID:12197 punctate epithelial keratoconjunctivitis A viral infectious disease that results in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding. DOID:0050142 GARD:6254 ICD10CM:A90 ICD9CM:061 MESH:D003715 NCI:C34528 SNOMEDCT_US_2020_03_01:38362002 UMLS_CUI:C0011311 Dengue Fever breakbone fever classic dengue disease_ontology classical dengue DOID:12205 dengue disease A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion. DOID:12595 DOID:12596 ICD10CM:O41.0 ICD9CM:658.0 MESH:D016104 NCI:C92839 SNOMEDCT_US_2020_03_01:157051001 UMLS_CUI:C0079924 Oligohydramnios - delivered antepartum oligohydramnios delivered oligohydramnios disease_ontology DOID:12215 oligohydramnios A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities. GARD:3243 ICD10CM:G31.83 ICD9CM:331.82 MESH:D020961 NCI:C84826 OMIM:127750 SNOMEDCT_US_2020_03_01:192808003 UMLS_CUI:C0752347 Dementia with Lewy bodies Diffuse Lewy body disease Lewy body disease Senile dementia of the Lewy body type disease_ontology DOID:12217 OMIM mapping confirmed by DO. [SN]. Lewy body dementia A connective tissue disease that is located_in cartilage. ICD10CM:M94.9 MESH:D002357 SNOMEDCT_US_2020_03_01:50927007 UMLS_CUI:C0007302 Cartilage disorder Chondropathy disease_ontology DOID:1222 cartilage disease ICD10CM:K31.2 ICD9CM:537.6 SNOMEDCT_US_2020_03_01:54051005 UMLS_CUI:C0267183 Hourglass stricture or stenosis of stomach disease_ontology DOID:12234 cascade stomach A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. DOID:1851 EFO:0004267 GARD:7459 ICD10CM:K74.3 ICD10CM:K74.5 ICD9CM:571.6 MESH:D008105 NCI:C27167 NCI:C51225 OMIM:109720 OMIM:613007 OMIM:613008 OMIM:614220 OMIM:614221 ORDO:186 SNOMEDCT_US_2020_03_01:1761006 SNOMEDCT_US_2020_03_01:31712002 UMLS_CUI:C0008312 UMLS_CUI:C0023892 biliary liver cirrhosis cholestatic cirrhosis chronic nonsuppurative destructive cholangitis primary biliary cirrhosis disease_ontology DOID:12236 Xref MGI. OMIM mapping confirmed by DO. [SN]. primary biliary cholangitis MESH:D001655 UMLS_CUI:C0005403 disease_ontology DOID:12237 bile reflux NCI:C6810 SNOMEDCT_US_2020_03_01:277664004 UMLS_CUI:C0349644 lymphoma of the testis malignant lymphoma of testis testicular Lymphoma disease_ontology DOID:12253 testicular lymphoma A blood coagulation disease that has_material_basis_in Factor IX deficiency, which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait. GARD:8732 ICD10CM:D67 ICD9CM:286.1 MESH:D002836 NCI:C26721 OMIM:306900 SNOMEDCT_US_2020_03_01:41788008 UMLS_CUI:C0008533 Congenital factor IX deficiency Congenital factor IX disorder deficiency, functional factor IX factor IX deficiency disease_ontology DOID:12259 OMIM mapping confirmed by DO. [SN]. hemophilia B ICD10CM:D70 ICD9CM:288.0 MESH:D009503 SNOMEDCT_US_2020_03_01:191336001 UMLS_CUI:C0027947 disease_ontology DOID:1227 neutropenia An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc. GARD:1433 ICD10CM:Q13.0 MESH:D003103 NCI:C98877 OMIM:120200 OMIM:120300 OMIM:216820 ORDO:194 ORDO:98945 SNOMEDCT_US_2020_03_01:93390002 UMLS_CUI:C0009363 coloboInOwlma of eye coloboInOwlma of macula congenital ocular coloboInOwlma disease_ontology DOID:12270 Xref MGI. OMIM mapping confirmed by DO. [SN]. coloboma An iris disease that is characterized by a complete or partial absence of the colored part of the eye. GARD:5816 ICD10CM:Q13.1 ICD9CM:743.45 MESH:D015783 NCI:C84563 OMIM:106210 SNOMEDCT_US_2020_03_01:69278003 UMLS_CUI:C0003076 Aplasia of iris disease_ontology DOID:12271 OMIM mapping confirmed by DO. [SN]. aniridia ICD10CM:H52.31 ICD9CM:367.31 MESH:D015858 SNOMEDCT_US_2020_03_01:3289004 UMLS_CUI:C0003081 disease_ontology DOID:12273 anisometropia MESH:D015858 NCI:C9277 UMLS_CUI:C1336711 disease_ontology DOID:12286 testicular leukemia A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine. ICD10CM:A98.0 ICD9CM:065.0 MESH:D006479 NCI:C34682 SNOMEDCT_US_2020_03_01:43489008 UMLS_CUI:C0019099 CHF Congo virus Congo-Crimean Hemorrhagic Fever Crimean hemorrhagic fever disease_ontology DOID:12287 Crimean-Congo hemorrhagic fever An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis. GARD:7862 ICD10CM:H20.82 ICD9CM:364.24 MESH:D014607 NCI:C85218 SNOMEDCT_US_2020_03_01:44923005 UMLS_CUI:C0042170 Harada's disease Vogt-Koyanagi syndrome uveomeningoencephalitic syndrome disease_ontology DOID:12297 Vogt-Koyanagi-Harada disease An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes. EFO:0004208 GARD:10751 ICD10CM:L80 ICD9CM:709.01 MESH:D014820 NCI:C26915 OMIM:193200 SNOMEDCT_US_2020_03_01:156437000 UMLS_CUI:C0042900 disease_ontology DOID:12306 OMIM mapping confirmed by DO. [LS]. vitiligo A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin without elevation of liver alanine transaminase and aspartate transaminase enzymes as a result of the deficient ability of hepatocytes to secrete conjugated bilirubin into the bile. GARD:6289 ICD10CM:E80.6 MESH:D007566 NCI:C34741 OMIM:237500 SNOMEDCT_US_2020_03_01:44553005 UMLS_CUI:C0022350 Dubin Johnson syndrome chronic idiopathic jaundice disease_ontology DOID:12308 OMIM mapping confirmed by DO. [SN]. Dubin-Johnson syndrome An epithelial-stromal TGFBI dystrophy that is characterized by progressive accumulation of deposits within the layers of the cornea. ICD10CM:H18.53 ICD9CM:371.53 MESH:D003317 NCI:C34651 SNOMEDCT_US_2020_03_01:45283008 UMLS_CUI:C0018179 granular corneal dystrophy disease_ontology DOID:12318 granular corneal dystrophy ICD9CM:416.8 SNOMEDCT_US_2020_03_01:194887007 UMLS_CUI:C0155673 disease_ontology DOID:12326 chronic pulmonary heart disease ICD10CM:F64.1 ICD9CM:302.3 MESH:D014190 NCI:C94359 SNOMEDCT_US_2020_03_01:472948001 UMLS_CUI:C0040774 Dual-role transvestism Fetishistic transvestism Transvestic fetishism cross dresser disease_ontology DOID:1233 transvestism ICD10CM:N46 ICD9CM:606 MESH:D007248 SNOMEDCT_US_2020_03_01:155924001 UMLS_CUI:C0021364 disease_ontology DOID:12336 male infertility ICD10CM:I86.1 ICD9CM:456.4 MESH:D014646 SNOMEDCT_US_2020_03_01:195480007 UMLS_CUI:C0042341 Scrotal varices disease_ontology DOID:12337 varicocele A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as. ICD10CM:F64.2 ICD9CM:302.6 SNOMEDCT_US_2020_03_01:5095008 UMLS_CUI:C0236802 disease_ontology DOID:1234 gender identity disorder A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space. NCI:C4832 SNOMEDCT_US_2020_03_01:307219002 UMLS_CUI:C0585129 disease_ontology DOID:12341 retroperitoneal sarcoma An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue. DOID:14708 GARD:1017 ICD10CM:Q78.0 ICD9CM:756.51 MESH:D010013 NCI:C26837 OMIM:PS166200 ORDO:666 SNOMEDCT_US_2020_03_01:78314001 UMLS_CUI:C0029434 Lobstein's syndrome Osteopsathyrosis Vrolik's disease brittle bone disease disease_ontology Fragilitas ossium DOID:12347 Xref MGI. OMIM mapping confirmed by DO. [SN]. osteogenesis imperfecta ICD10CM:F65.0 ICD9CM:302.81 MESH:D005329 NCI:C94353 SNOMEDCT_US_2020_03_01:192513009 UMLS_CUI:C0015957 disease_ontology DOID:1235 fetishism DOID:12350 ICD9CM:571.1 NCI:C34352 SNOMEDCT_US_2020_03_01:9953008 UMLS_CUI:C0001306 Alcoholic Hepatitis Alcoholic hepatitis acute Alcoholic Hepatitis acute alcoholic hepatitis acute alcoholic liver disease disease_ontology DOID:12351 alcoholic hepatitis A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection. GARD:10812 ICD10CM:H69.0 ICD9CM:381.7 SNOMEDCT_US_2020_03_01:30280005 UMLS_CUI:C0155434 disease_ontology DOID:12358 patulous eustachian tube An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland. EFO:0004237 ICD10CM:E05.0 MESH:D006111 NCI:C3071 SNOMEDCT_US_2020_03_01:154655004 UMLS_CUI:C0018213 Grave's disease Graves disease exophthalmic goiter disease_ontology Basedow's disease DOID:12361 Xref MGI. OMIM mapping confirmed by DO. [SN]. Graves' disease A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. DOID:12552 EFO:0001068 GARD:6961 ICD10CM:B54 ICD9CM:084 MESH:D008288 NCI:C34797 SNOMEDCT_US_2020_03_01:154374002 UMLS_CUI:C0024530 induced malaria disease_ontology DOID:12365 Xref MGI. malaria ICD10CM:H18.4 ICD9CM:371.4 SNOMEDCT_US_2020_03_01:111521006 UMLS_CUI:C0155118 disease_ontology DOID:1237 corneal degeneration A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses. ICD10CM:J18.0 ICD9CM:485 MESH:D001996 NCI:C26710 SNOMEDCT_US_2020_03_01:155551009 UMLS_CUI:C0006285 Chest infection - bronchopneumonia bronchial pneumonia lobular pneumonia disease_ontology DOID:12375 bronchopneumonia A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy. GARD:7674 ICD10CM:G12.9 ICD9CM:335.1 MESH:D009134 NCI:C85075 SNOMEDCT_US_2020_03_01:5262007 UMLS_CUI:C0026847 disease_ontology DOID:12377 spinal muscular atrophy MESH:D017029 SNOMEDCT_US_2020_03_01:307358009 UMLS_CUI:C0085417 Complex partial epileptic seizure Psychomotor epilepsy epilepsy, psychomotor psychomotor epilepsy disease_ontology DOID:12382 complex partial epilepsy An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood. ICD9CM:009.2 MESH:D004403 SNOMEDCT_US_2020_03_01:154268000 UMLS_CUI:C0013369 Infectious diarrhea disease_ontology DOID:12384 dysentery A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces. DOID:11378 DOID:12950 DOID:2041 DOID:924 DOID:925 GARD:4818 ICD10CM:A03 ICD10CM:A03.0 ICD10CM:A03.1 ICD10CM:A03.2 ICD9CM:004 ICD9CM:004.0 ICD9CM:004.1 ICD9CM:004.2 KEGG:05131 MESH:D004405 NCI:C157978 SNOMEDCT_US_2020_03_01:111817006 SNOMEDCT_US_2020_03_01:34335000 SNOMEDCT_US_2020_03_01:55760004 SNOMEDCT_US_2020_03_01:66301008 UMLS_CUI:C0013371 UMLS_CUI:C0302358 UMLS_CUI:C0302359 UMLS_CUI:C0302360 Shigella boydii infectious disease Shigella flexneri infectious disease Shigella gastroenteritis Shigella sonnei infectious disease bacillary dysentery disease_ontology DOID:12385 shigellosis A kidney disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH). GARD:7178 ICD10CM:N25.1 ICD9CM:588.1 MESH:D018500 NCI:C84919 OMIM:125800 OMIM:304800 ORDO:223 SNOMEDCT_US_2020_03_01:123294004 UMLS_CUI:C0162283 disease_ontology vasopressin-resistant diabetes insipidus DOID:12387 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. nephrogenic diabetes insipidus MESH:D020790 NCI:C84933 OMIM:125700 OMIM:304900 SNOMEDCT_US_2020_03_01:267393007 UMLS_CUI:C0687720 Pituitary diabetes insipidus Vasopressin deficiency central diabetes insipidus vasopressin defective diabetes insipidus disease_ontology DOID:12388 OMIM mapping confirmed by DO. [SN]. neurohypophyseal diabetes insipidus DOID:14446 ICD9CM:374.00 MESH:D004774 SNOMEDCT_US_2020_03_01:246821008 UMLS_CUI:C0014390 disease_ontology DOID:12397 entropion An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life. ICD10CM:F63.0 ICD9CM:312.31 MESH:D005715 NCI:C94335 OMIM:606349 SNOMEDCT_US_2020_03_01:18085000 UMLS_CUI:C0030662 Compulsive gambling Pathological gambling disease_ontology DOID:12399 OMIM mapping confirmed by DO. [SN]. pathological gambling A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. DOID:9145 ICD10CM:C95.90 ICD9CM:208 MESH:D007938 NCI:C3161 SNOMEDCT_US_2020_03_01:255049003 UMLS_CUI:C0023418 disease_ontology DOID:1240 leukemia An impulse control disorder that involves the repeated impulse to steal for no great gain, when he or she has sufficient money to pay for the item and no need for what is stolen. ICD10CM:F63.2 ICD9CM:312.32 MESH:D007174 NCI:C94333 SNOMEDCT_US_2020_03_01:69361009 UMLS_CUI:C0022734 Pathological stealing disease_ontology DOID:12400 kleptomania An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness. DOID:9404 ICD10CM:F60.3 ICD10CM:F63.81 ICD9CM:301.3 ICD9CM:312.34 MESH:D007174 NCI:C94332 SNOMEDCT_US_2020_03_01:192096007 SNOMEDCT_US_2020_03_01:268757006 UMLS_CUI:C0021776 UMLS_CUI:C0152183 explosive personality disorder disease_ontology DOID:12401 intermittent explosive disorder An impulse control disorder that involves the uncontrollable impulse to repeatedly set fires with no obvious motive. ICD10CM:F63.1 ICD9CM:312.33 MESH:D005391 NCI:C94334 SNOMEDCT_US_2020_03_01:600009 UMLS_CUI:C0016142 Pathological firesetting firesetting behavior disease_ontology DOID:12402 pyromania A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot. ICD10CM:B35.3 ICD9CM:110.4 MESH:D014008 SNOMEDCT_US_2020_03_01:186993002 UMLS_CUI:C0040259 Athlete's foot Dermatophytosis of foot disease_ontology ringworm of foot DOID:12403 tinea pedis An eye disease that involves the globe of the eye. ICD10CM:H44.39 ICD9CM:360.29 SNOMEDCT_US_2020_03_01:194638007 UMLS_CUI:C0154780 disease_ontology DOID:1242 globe disease ICD9CM:378.81 SNOMEDCT_US_2020_03_01:1534008 UMLS_CUI:C0702143 Palsy of conjugate gaze disease_ontology DOID:12445 conjugate gaze palsy An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow. GARD:5836 ICD10CM:D61.9 ICD9CM:284.9 MESH:D000741 NCI:C2870 OMIM:609135 SNOMEDCT_US_2020_03_01:154807001 UMLS_CUI:C0002874 disease_ontology DOID:12449 OMIM mapping confirmed by DO. [SN]. aplastic anemia A female reproductive organ cancer that is located_in the vulva. DOID:1282 GARD:9349 ICD10CM:C51 ICD9CM:184.4 MESH:D014846 NCI:C3443 NCI:C7502 SNOMEDCT_US_2020_03_01:126922007 SNOMEDCT_US_2020_03_01:94143002 UMLS_CUI:C0042995 UMLS_CUI:C0375071 Ca vulva Vulvar tumor malignant Vulvar tumor malignant neoplasm of vulva malignant tumor of vulva neoplasm of vulva vulval cancer vulval neoplasm vulvar neoplasm disease_ontology DOID:1245 vulva cancer An anemia that is characterized by a reduction in the number of red blood cells, white blood cells, and platelets. ICD10CM:D61.81 ICD9CM:284.1 MESH:D010198 NCI:C34889 SNOMEDCT_US_2020_03_01:127034005 UMLS_CUI:C0030312 disease_ontology DOID:12450 pancytopenia MESH:D010198 MESH:D013436 SNOMEDCT_US_2020_03_01:32117000 UMLS_CUI:C0038732 Sulfemoglobinemia Sulfhemoglobinemia disease_ontology DOID:12451 sulfhemoglobinemia A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. DOID:13997 DOID:2212 DOID:9474 ICD10CM:D68.9 ICD9CM:286 MESH:D001778 NCI:C2902 SNOMEDCT_US_2020_03_01:64779008 UMLS_CUI:C0005779 coagulation protein disease postpartum coagulation defect postpartum coagulation defect with delivery inherited blood coagulation disease disease_ontology DOID:1247 blood coagulation disease A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species. ICD10CM:B81.1 ICD9CM:127.5 MESH:D017189 SNOMEDCT_US_2020_03_01:52979002 UMLS_CUI:C0006897 Capillaria infection disease_ontology DOID:12474 capillariasis A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve). GARD:5906 ICD10CM:G51.0 ICD9CM:351.0 MESH:D020330 SNOMEDCT_US_2020_03_01:193093009 UMLS_CUI:C0376175 Bell palsy Bell's (facial) palsy disease_ontology DOID:12506 Bell's palsy An urogenital tuberculosis that is located_in epididymis, has_symptom pain and has_symptom scrotal swelling. ICD9CM:016.4 SNOMEDCT_US_2020_03_01:83652003 UMLS_CUI:C0152814 disease_ontology DOID:1251 tuberculous epididymitis MESH:D012167 NCI:C50732 SNOMEDCT_US_2020_03_01:40024006 UMLS_CUI:C0035321 Retinal break Retinal dialysis Retinal tear disease_ontology DOID:12514 retinal perforation A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation. GARD:10720 ICD10CM:B79 ICD9CM:127.3 MESH:D014257 NCI:C128399 SNOMEDCT_US_2020_03_01:60570001 UMLS_CUI:C0040954 Infection by Trichuris trichura Trichuriasis infection Whipworm disease trichuris trichiura infection disease_ontology DOID:1252 trichuriasis GARD:7733 ICD10CM:G57.5 ICD9CM:355.5 MESH:D013641 NCI:C85183 SNOMEDCT_US_2020_03_01:155077008 UMLS_CUI:C0039319 disease_ontology DOID:12526 tarsal tunnel syndrome A blood coagulation disease that is a hereditary abnormality which slows the blood clotting process. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion. GARD:7867 ICD10CM:D68.0 ICD9CM:286.4 MESH:D014842 NCI:C68677 SNOMEDCT_US_2020_03_01:11093006 UMLS_CUI:C0042974 vascular hemophilia vascular pseudohemophilia von Willebrand disease von Willebrand disorder von Willebrand's-Jurgens' disease von Willebrand-Jrgens disease disease_ontology DOID:12531 OMIM mapping confirmed by DO. [SN]. von Willebrand's disease A trichostrongyloidiasis that involves infection of the small intestine with Trichostrongylus colubriformis or Trichostrongylus axei, which results in abdominal pain, diarrhea, anorexia, headache, fatigue, anemia and eosinophilia. ICD10CM:B81.2 ICD9CM:127.6 MESH:D014253 SNOMEDCT_US_2020_03_01:33710003 UMLS_CUI:C0040948 Infection by Trichostrongylus Infection by Trichostrongylus species Trichostrongyliasis disease_ontology DOID:1254 trichostrongylosis MESH:D014253 A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:12547 MESH:D006506 NCI:C3096 SNOMEDCT_US_2020_03_01:40468003 UMLS_CUI:C0019159 Viral hepatitis, type A disease_ontology Viral hepatitis A DOID:12549 hepatitis A A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by nematodes of the superfamily Trichostrongyloidea. MESH:D014252 UMLS_CUI:C0040947 disease_ontology DOID:1255 trichostrongyloidiasis A kidney disease that is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. GARD:6588 ICD10CM:D59.3 ICD9CM:283.11 MESH:D006463 NCI:C75545 ORDO:2134 SNOMEDCT_US_2020_03_01:123308008 UMLS_CUI:C0019061 haemolytic-uraemic syndrome hemolytic uremic syndrome disease_ontology DOID:12554 Xref MGI. hemolytic-uremic syndrome ICD10CM:H50.81 ICD9CM:378.71 MESH:D004370 NCI:C84678 OMIM:126800 OMIM:604356 ORDO:233 SNOMEDCT_US_2020_03_01:60318001 UMLS_CUI:C0013261 Duane's syndrome Stilling-Turk-Duane syndrome disease_ontology DOID:12557 OMIM mapping confirmed by DO. [SN]. Duane retraction syndrome GARD:4503 ICD10CM:H49.4 ICD9CM:378.72 MESH:D017246 OMIM:PS157640 SNOMEDCT_US_2020_03_01:194126004 UMLS_CUI:C0162674 progressive external ophthalmoplegia disease_ontology DOID:12558 chronic progressive external ophthalmoplegia An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis. ICD9CM:733.02 OMIM:259750 SNOMEDCT_US_2020_03_01:3345002 UMLS_CUI:C0158447 Idiopathic osteoporosis juvenile osteoporosis disease_ontology DOID:12559 idiopathic juvenile osteoporosis A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page. MESH:D060705 Mathematics disorder disorder of arithmetical skills disease_ontology DOID:12568 dyscalculia A glaucoma characterized by glaucomatous optic atrophy secondary to a lens abnormality and has_symptom progressive decreased vision, especially decreased peripheral vision. Phacogenic glaucoma can be caused by cataracts, trauma to the eye, or age-related damage that obstructs aqueous outflow, leading to inappropriately increased intraocular pressure and eventual optic nerve atrophy with associated vision loss. ICD9CM:365.59 SNOMEDCT_US_2020_03_01:84333006 UMLS_CUI:C0154959 disease_ontology DOID:12571 phacogenic glaucoma ICD10CM:P72.1 ICD9CM:775.3 NCI:C114906 SNOMEDCT_US_2020_03_01:13795004 UMLS_CUI:C0158983 Neonatal thyrotoxicosis disease_ontology DOID:12573 neonatal thyrotoxicosis MESH:D014524 NCI:C79804 SNOMEDCT_US_2020_03_01:95588004 UMLS_CUI:C0041972 Obstruction of urethra disease_ontology DOID:12577 urethral obstruction A syndrome that has_material_basis_in deletion of the end of the chromosome 5 p arm and that is characterized by intellectual disability, delayed development, small head size, low birth weight, weak muscle tone widely set eyes, low-set ears, a small jaw, a rounded face and a high-pitched cry that sounds like that of a cat. GARD:6213 ICD10CM:Q93.4 ICD9CM:758.31 MESH:D003410 NCI:C34518 OMIM:123450 SNOMEDCT_US_2020_03_01:70173007 UMLS_CUI:C0010314 5p deletion syndrome 5p partial monosomy syndrome Cri-du-chat syndrome chromosome 5 short arm deletion syndrome chromosome 5p deletion syndrome disease_ontology DOID:12580 OMIM mapping confirmed by DO. [SN]. Cri-Du-Chat syndrome A chromosomal deletion disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and that is characterized by variable developmental problems and schizoid features. ICD10CM:Q93.81 ICD9CM:758.32 MESH:D004062 OMIM:192430 SNOMEDCT_US_2020_03_01:205642004 UMLS_CUI:C0220704 22q11 Deletion Syndrome Shprintzen syndrome VCF-Velocardiofacial syndrome deletion 22q11.2 syndrome disease_ontology DOID:12583 OMIM mapping confirmed by DO. [LS]. velocardiofacial syndrome A renal agenesis characterized by the typical physical appearance and associated pulmonary hypoplasia of a newborn as a direct result of kidney failure, oligohydramnios and compression while in the uterus. GARD:4462 ICD10CM:Q60.6 NCI:C40435 SNOMEDCT_US_2020_03_01:41962002 UMLS_CUI:C0178426 Potter sequence Potter syndrome disease_ontology DOID:12594 Potter's syndrome MESH:D010249 SNOMEDCT_US_2020_03_01:280483007 UMLS_CUI:C0030455 pelvic cellulitis disease_ontology DOID:1260 parametritis A lymphoid leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity producing large numbers of white blood cells to be produced and enter the blood stream. DOID:12621 ICD10CM:C95.00 ICD9CM:208.0 NCI:C9300 OMIM:308960 SNOMEDCT_US_2020_03_01:24072005 UMLS_CUI:C0085669 UMLS_CUI:C1378511 Stem cell Leukemia Stem cell leukaemia disease_ontology DOID:12603 acute leukemia ICD10CM:K31.1 MESH:D011707 NCI:C34966 SNOMEDCT_US_2020_03_01:367403001 UMLS_CUI:C0034194 disease_ontology DOID:12639 pyloric stenosis ICD10CM:K44 MESH:D006551 NCI:C98945 OMIM:142400 SNOMEDCT_US_2020_03_01:236053002 SNOMEDCT_US_2020_03_01:3662000 SNOMEDCT_US_2020_03_01:84089009 UMLS_CUI:C0267725 UMLS_CUI:C0376710 UMLS_CUI:C3489393 Diaphragmatic - hiatus -hernia hiatal hernia disease_ontology DOID:12642 OMIM mapping confirmed by DO. [SN]. hiatus hernia ICD10CM:H93.3 ICD9CM:388.5 MESH:D000160 NCI:C27207 SNOMEDCT_US_2020_03_01:77949003 UMLS_CUI:C0001163 acoustic nerve disease disease_ontology DOID:12657 vestibulocochlear nerve disease A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis. GARD:7323 ICD10CM:B41 ICD9CM:116.1 MESH:D010229 NCI:C34891 SNOMEDCT_US_2020_03_01:59925007 UMLS_CUI:C0030409 Mucocutaneous-lymphangitic paracoccidioidomycosis Paracoccidioidomycosis paracoccidioidal mycosis disease_ontology DOID:12662 paracoccidioidomycosis A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening. DOID:13067 GARD:5931 ICD10CM:B40 ICD9CM:116.0 MESH:D001759 NCI:C34428 SNOMEDCT_US_2020_03_01:266217003 UMLS_CUI:C0005716 Blastomyces Dermatitidis Infection Blastomycotic infection Chicago disease Gilchrist's disease Infection by Blastomyces dermatitidis North American blastomycosis disease_ontology DOID:12663 blastomycosis DOID:12671 ICD10CM:H53.30 ICD9CM:368.30 NCI:C34422 SNOMEDCT_US_2020_03_01:83275001 UMLS_CUI:C0005461 simultaneous visual perception without fusion disease_ontology DOID:12667 binocular vision disease ICD10CM:H53.31 ICD9CM:368.34 SNOMEDCT_US_2020_03_01:79195003 UMLS_CUI:C0155010 disease_ontology DOID:12668 abnormal retinal correspondence ICD10CM:E83.52 ICD9CM:275.42 MESH:D006934 NCI:C3112 SNOMEDCT_US_2020_03_01:154752005 UMLS_CUI:C0020437 disease_ontology DOID:12678 hypercalcemia GARD:7177 MESH:D009397 NCI:C84918 SNOMEDCT_US_2020_03_01:154752005 UMLS_CUI:C0027709 disease_ontology DOID:12679 nephrocalcinosis A brain disease that is characterized by damage to neurons of the corticobulbar tract, has_symptom dysarthria, has_symptom dysphagia, has_symptom spasticity located_in tongue, has_symptom abnormal bulbar reflexes, and has_symptom emotional outbursts. ICD9CM:335.23 MESH:D020828 NCI:C129934 SNOMEDCT_US_2020_03_01:7379000 UMLS_CUI:C0033790 Pseudobulbar palsy pseudobulbar paralysis disease_ontology DOID:12680 pseudobulbar palsy A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent. ICD10CM:H81.2 ICD9CM:386.12 MESH:D020338 SNOMEDCT_US_2020_03_01:232293008 UMLS_CUI:C0751908 Epidemic neurolabyrinthitis Vestibular neuritis disease_ontology DOID:12683 vestibular neuronitis GARD:223 MESH:D009464 NCI:C3276 SNOMEDCT_US_2020_03_01:269643009 UMLS_CUI:C0027859 Vestibular Neurilemmoma Vestibular schwannoma disease_ontology DOID:12689 acoustic neuroma A nervous system disease that is characterized by complete paralysis of all voluntary muscles except for the ones that control the movements of the eyes. GARD:6919 ICD10CM:G83.5 ICD9CM:344.81 MESH:D000080422 SNOMEDCT_US_2020_03_01:38023001 UMLS_CUI:C0023944 Locked in syndrome Locked-in state disease_ontology DOID:12697 locked-in syndrome A disorder of sexual development that is characterized by enlargement or swelling of male breast tissue resulting from elevated male estrogen levels or imbalanced estrogen and testosterone levels. ICD10CM:N62 MESH:D006177 NCI:C3073 SNOMEDCT_US_2020_03_01:155963008 UMLS_CUI:C0018418 disease_ontology DOID:12698 gynecomastia A cell type benign neoplasm that is a benign tumor of smooth muscle cells. MESH:D007889 NCI:C3157 SNOMEDCT_US_2020_03_01:702978006 UMLS_CUI:C0023267 leiomyomatous neoplasm leiomyomatous tumor disease_ontology DOID:127 leiomyoma A vascular disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins. GARD:6626 ICD10CM:I78.0 ICD9CM:448.0 MESH:D013683 NCI:C35064 OMIM:187300 OMIM:600376 OMIM:601101 OMIM:615506 ORDO:774 SNOMEDCT_US_2020_03_01:266324004 UMLS_CUI:C0039445 Osler hemorrhagic telangiectasia syndrome Osler-Weber-Rendu disease Rendu-Osler-Weber disease disease_ontology DOID:1270 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary hemorrhagic telangiectasia An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood. DOID:12699 ICD10CM:E22.1 MESH:D002640 MESH:D006966 SNOMEDCT_US_2020_03_01:190468001 SNOMEDCT_US_2020_03_01:85039006 UMLS_CUI:C0008043 UMLS_CUI:C0020514 Chiari-Frommel syndrome Pregnancy-related A-G syndrome hyperprolactinaemia disease_ontology DOID:12700 hyperprolactinemia An autosomal recessive cerebellar ataxia that is characterized by cerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancy and that has_material_basis_in homozygous or compound heterozygous mutation in the ATM gene on chromosome 11q22. GARD:5862 MESH:D001260 NCI:C2887 OMIM:208900 SNOMEDCT_US_2020_03_01:68504005 UMLS_CUI:C0004135 Boder-Sedgwick syndrome Louis Bar syndrome disease_ontology DOID:12704 OMIM mapping confirmed by DO. [SN]. ataxia telangiectasia MESH:D001260 DOID:0050555 GARD:6468 ICD9CM:334.0 MESH:D005621 NCI:C84718 SNOMEDCT_US_2020_03_01:155011003 UMLS_CUI:C0016719 Friedreich ataxia 1 Friedreich's ataxia Friedreich's tabes disease_ontology DOID:12705 Xref MGI. Friedreich ataxia MESH:D005621 A vascular disease that is located_in the capillaries. ICD10CM:I78 ICD9CM:448 SNOMEDCT_US_2020_03_01:58729003 UMLS_CUI:C0155765 disease of capillaries disease_ontology DOID:1271 capillary disease A kidney disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy). GARD:206 ICD10CM:Q61.5 NCI:C123200 OMIM:PS256100 ORDO:655 SNOMEDCT_US_2020_03_01:204958008 UMLS_CUI:C0687120 medullary cystic disease medullary cystic kidney disease_ontology DOID:12712 Xref MGI. OMIM mapping confirmed by DO. [SN]. nephronophthisis A syndrome characterized by short limbs, short ribs, postaxial polydactyly, dysplastic nails and teeth, and in many patients congenital cardiac defects that has_material_basis_in homozygous or compound heterozygous mutation in either EVC or EVC2 on chromosome 4p16.2. GARD:1301 ICD10CM:Q77.6 ICD9CM:756.55 MESH:D004613 NCI:C84684 OMIM:225500 SNOMEDCT_US_2020_03_01:62501005 UMLS_CUI:C0013903 Chondroectodermal dysplasia Ellis-van Creveld syndrome mesoectodermal dysplasia disease_ontology DOID:12714 OMIM mapping confirmed by DO. [SN]. Ellis-Van Creveld syndrome A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts. DOID:11395 DOID:13859 ICD10CM:P22.0 MESH:D006819 OMIM:267450 SNOMEDCT_US_2020_03_01:26168007 UMLS_CUI:C0020192 HMD - Hyaline membrane disease Neonatal respiratory Distress syndrome hyaline membrane disease pulmonary hyaline membrane disease pulmonary hypoperfusion syndrome of newborn respiratory distress syndrome of newborn disease_ontology DOID:12716 newborn respiratory distress syndrome MESH:D013684 NCI:C28194 SNOMEDCT_US_2020_03_01:112641009 UMLS_CUI:C0039446 telangiectasia disease_ontology DOID:1272 telangiectasis ICD10CM:I67.2 ICD9CM:437.0 MESH:D002537 NCI:C34459 SNOMEDCT_US_2020_03_01:266258005 UMLS_CUI:C0007775 Cerebral atherosclerosis disease_ontology DOID:12720 cerebral atherosclerosis An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results in irregular ossification centers of the located in hip or located in knee. The disease has symptom fatigue, has symptom joint pain. GARD:10756 ICD9CM:756.56 MESH:D010009 ORDO:251 SNOMEDCT_US_2020_03_01:59708000 UMLS_CUI:C0026760 polyepiphyseal dysplasia disease_ontology DOID:12721 Xref MGI. multiple epiphyseal dysplasia A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress. MESH:D018357 NCI:C3354 SNOMEDCT_US_2020_03_01:186750007 UMLS_CUI:C0035235 disease_ontology DOID:1273 respiratory syncytial virus infectious disease ICD10CM:K03.4 ICD9CM:521.5 MESH:D006936 SNOMEDCT_US_2020_03_01:78537008 UMLS_CUI:C0020441 Cementation hyperplasia disease_ontology DOID:12733 hypercementosis ICD10CM:H18.72 ICD9CM:371.73 SNOMEDCT_US_2020_03_01:193849005 UMLS_CUI:C0152440 disease_ontology DOID:12753 corneal staphyloma DOID:12760 ICD10CM:C69.3 ICD9CM:190.6 MESH:D002830 NCI:C2949 NCI:C3566 SNOMEDCT_US_2020_03_01:127001008 SNOMEDCT_US_2020_03_01:93755007 UMLS_CUI:C0008523 UMLS_CUI:C0153630 Choroidal tumor choroid neoplasm malignant tumor of choroid malignant tumor of the Choroid neoplasm of choroid disease_ontology DOID:12759 choroid cancer GARD:7777 MESH:D020333 NCI:C85193 SNOMEDCT_US_2020_03_01:75111000 UMLS_CUI:C0040381 Tolosa-Hunt syndrome disease_ontology DOID:1278 tolosa-hunt syndrome ICD9CM:374.14 SNOMEDCT_US_2020_03_01:28914006 UMLS_CUI:C0155196 disease_ontology DOID:12782 cicatricial ectropion A migraine that is characterized by migraine headaches that are not accompanied by an aura. ICD10CM:G43.0 ICD9CM:346.1 MESH:D020326 NCI:C117004 OMIM:607501 SNOMEDCT_US_2020_03_01:56097005 UMLS_CUI:C0338480 common migraine disease_ontology DOID:12783 Xref MGI. migraine without aura GARD:7061 GARD:7237 ICD9CM:378.9 MESH:D015835 SNOMEDCT_US_2020_03_01:45030009 UMLS_CUI:C0028850 disorder of eye movements eye movement disorder disease_ontology DOID:1279 ocular motility disease A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine. DOID:14716 GARD:7065 ICD10CM:E76.3 ICD9CM:277.5 MESH:D009083 NCI:C61259 OMIM:252700 OMIM:PS607014 ORDO:79213 SNOMEDCT_US_2020_03_01:267452003 UMLS_CUI:C0026703 disease_ontology DOID:12798 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. mucopolysaccharidosis A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase. GARD:7095 MESH:D009087 NCI:C61264 OMIM:253200 SNOMEDCT_US_2020_03_01:69463008 UMLS_CUI:C0026709 MPS VI - Maroteaux-Lamy syndrome Maroteaux - Lamy syndrome Maroteaux-Lamy syndrome arylsulfatase B deficiency deficiency of N-acetylgalactosamine-4-sulfatase disease_ontology DOID:12800 OMIM mapping confirmed by DO. [SN]. mucopolysaccharidosis VI A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain. DOID:14729 DOID:14788 MESH:D009084 NCI:C61262 OMIM:252940 ORDO:581 SNOMEDCT_US_2020_03_01:190936000 UMLS_CUI:C0026706 Mucopolysaccharidosis, MPS-III N-sulphoglucosamine sulphohydrolase deficiency Sanfilippo's syndrome heparan sulfate sulfatase deficiency naglu deficiency disease_ontology DOID:12801 OMIM mapping confirmed by DO. [SN]. mucopolysaccharidosis III A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain. DOID:0050808 DOID:14767 ICD10CM:E76.219 MESH:D009085 NCI:C61263 SNOMEDCT_US_2020_03_01:378007 UMLS_CUI:C0026707 Mucopolysaccharidosis, MPS-IV deficiency of N-acetylgalactosamine-6-sulphatase deficiency of chondroitinsulphatase galactosamine-6-sulfatase deficiency Osteochondrodystrophy chondroosteodystrophy disease_ontology DOID:12804 OMIM mapping confirmed by DO. [SN]. mucopolysaccharidosis IV ICD10CM:G82.5 ICD9CM:344.00 MESH:D011782 NCI:C50721 SNOMEDCT_US_2020_03_01:11538006 UMLS_CUI:C0034372 tetraplegia disease_ontology DOID:12835 quadriplegia MESH:D013958 NCI:C112836 SNOMEDCT_US_2020_03_01:190262002 UMLS_CUI:C0040127 Thyroid crisis Thyrotoxic crisis disease_ontology DOID:12837 thyroid crisis A female reproductive system disease that is characteried by the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening. ICD9CM:618.8 UMLS_CUI:C0029801 disease_ontology DOID:1284 prolapse of female genital organ A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition. GARD:9742 ICD10CM:B76.0 MESH:D000724 NCI:C35805 SNOMEDCT_US_2020_03_01:85807000 UMLS_CUI:C0002831 disease_ontology DOID:12841 ancylostomiasis MESH:D000724 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system. GARD:6554 ICD10CM:G61.0 MESH:D020275 NCI:C116345 OMIM:139393 SNOMEDCT_US_2020_03_01:155082001 UMLS_CUI:C0018378 Infectious neuronitis Post-infectious polyneuritis Postinfectious polyneuritis acute infective polyneuritis acute inflammatory demyelinating polyradiculopathy acute postinfectious polyneuropathy disease_ontology DOID:12842 OMIM mapping confirmed by DO. [SN]. Guillain-Barre syndrome An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. EFO:0003758 ICD10CM:F84.0 ICD9CM:299.0 MESH:D001321 NCI:C97161 OMIM:209850 ORDO:106 SNOMEDCT_US_2020_03_01:38763009 UMLS_CUI:C0004352 Kanner's syndrome autism autistic disorder of childhood onset childhood autism infantile autism disease_ontology DOID:12849 Xref MGI. OMIM mapping confirmed by DO. [SN]. autistic disorder MESH:D012002 SNOMEDCT_US_2020_03_01:5964004 UMLS_CUI:C0034882 disease_ontology DOID:1285 rectal disease A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities. GARD:6677 ICD10CM:G10 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 SNOMEDCT_US_2020_03_01:155006000 UMLS_CUI:C0020179 HD Huntington disease Huntington's chorea disease_ontology DOID:12858 Huntington's disease A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. DOID:73 ICD9CM:429.2 MESH:D002318 NCI:C2931 SNOMEDCT_US_2020_03_01:266275004 UMLS_CUI:C0007222 disease of subdivision of hemolymphoid system disease_ontology DOID:1287 cardiovascular system disease A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia. GARD:3668 ICD10CM:G61.0 MESH:D019846 NCI:C116958 SNOMEDCT_US_2020_03_01:1767005 UMLS_CUI:C0393799 Fisher's syndrome Miller-Fisher variant of Guillain-Barre syndrome disease_ontology DOID:12889 Miller Fisher syndrome A central nervous system disease that results in the progressive deterioration of function or structure of neurons. DOID:4874 ICD10CM:G31.9 MESH:D019636 NCI:C27090 SNOMEDCT_US_2020_03_01:362975008 UMLS_CUI:C0524851 UMLS_CUI:C1285162 Neurodegenerative disease degenerative disease disease_ontology DOID:1289 neurodegenerative disease An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva. DOID:416 GARD:10252 ICD10CM:M35.0 ICD10CM:M35.00 ICD9CM:710.2 MESH:D012859 NCI:C26883 NCI:C70647 OMIM:270150 SNOMEDCT_US_2020_03_01:267875002 SNOMEDCT_US_2020_03_01:83901003 UMLS_CUI:C0086981 UMLS_CUI:C1527336 Sicca syndrome Sjogren syndrome xerodermosteosis disease_ontology DOID:12894 OMIM mapping confirmed by DO. [LS]. Sjogren's syndrome GARD:8444 MESH:D007638 SNOMEDCT_US_2020_03_01:78946008 UMLS_CUI:C0022575 KCS disease_ontology DOID:12895 keratoconjunctivitis sicca An autoimmune disease that is characterized by chronic enlargement of the glands of the head and neck, has_symptom lumps of the face and neck, dry eyes, dry mouth, and intermittent fever, and is often associated with an underlying autoimmune disorder, hematologic malignancy, tuberculosis infection, or syphilis infection. GARD:7043 ICD10CM:K11.8 MESH:D008882 NCI:C34819 SNOMEDCT_US_2020_03_01:7826003 UMLS_CUI:C0026103 IgG4-related dacryoadenitis and sialadenitis Mikulicz's disease disease_ontology DOID:12900 Mikulicz disease ICD10CM:K11.8 MESH:D012797 SNOMEDCT_US_2020_03_01:109769000 UMLS_CUI:C0037033 Necrotizing sialometaplasia disease_ontology DOID:12901 necrotizing sialometaplasia ICD10CM:K11.6 ICD9CM:527.6 NCI:C27649 SNOMEDCT_US_2020_03_01:196508008 UMLS_CUI:C0026686 Mucous retention cyst of salivary gland Ranula Salivary Cyst Salivary gland mucocele disease_ontology DOID:12904 mucocele of salivary gland An endocardium disease that is characterized by a thickening of the inmost lining of the heart chambers due to an increase in the amount of supporting connective tissue and elastic fibers. GARD:2121 GARD:6336 ICD10CM:I42.4 ICD9CM:425.3 MESH:D004695 NCI:C98922 OMIM:226000 SNOMEDCT_US_2020_03_01:65457005 UMLS_CUI:C0014117 Elastomyofibrosis disease_ontology DOID:12929 OMIM mapping confirmed by DO. [SN]. endocardial fibroelastosis MESH:D004695 An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently. EFO:0000407 GARD:221 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 SNOMEDCT_US_2020_03_01:74368002 UMLS_CUI:C0007193 primary dilated cardiomyopathy disease_ontology Congestive cardiomyopathy Familial dilated cardiomyopathy Familial dilated cardiomyopathy Idiopathic dilation cardiomyopathy Idiopathic dilation cardiomyopathy DOID:12930 Xref MGI. OMIM mapping confirmed by DO. [LS]. dilated cardiomyopathy GARD:6340 ICD9CM:425.0 MESH:D004719 NCI:C34585 SNOMEDCT_US_2020_03_01:111507009 UMLS_CUI:C0553980 African endomyocardial fibrosis Becker's disease Endomyocardial sclerosis Obscure African cardiomyopathy obscure African cardiomyopathy disease_ontology DOID:12932 endomyocardial fibrosis GARD:6817 ICD10CM:H49.81 MESH:D007625 NCI:C84798 OMIM:530000 SNOMEDCT_US_2020_03_01:25792000 UMLS_CUI:C0022541 disease_ontology DOID:12934 OMIM mapping confirmed by DO. [SN]. Kearns-Sayre syndrome A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C4866 UMLS_CUI:C0677055 Vulvar carcinoma disease_ontology carcinoma of vulva DOID:1294 vulva carcinoma ICD10CM:H02.2 ICD9CM:374.2 SNOMEDCT_US_2020_03_01:193936001 UMLS_CUI:C0152226 disease_ontology DOID:12959 lagophthalmos A synostosis that results_in craniosynostosis and syndactyly. DOID:0080004 ICD9CM:755.55 MESH:D000168 NCI:C34348 OMIM:101200 SNOMEDCT_US_2020_03_01:63661009 UMLS_CUI:C1510455 Apert syndrome disease_ontology DOID:12960 OMIM mapping confirmed by DO. [SN]. acrocephalosyndactylia MESH:D000168 A hematologic cancer located_in the central nervous system. NCI:C5440 UMLS_CUI:C1332884 Leukemia of the CNS disease_ontology DOID:12969 central nervous system leukemia A congenital hemolytic anemia characterized by the production of red blood cells with a sphere shape, rather than the normal biconcave disk shape. GARD:6639 ICD10CM:D58.0 ICD9CM:282.0 MESH:D013103 NCI:C97074 ORDO:822 SNOMEDCT_US_2020_03_01:154795009 UMLS_CUI:C0037889 Congenital spherocytic hemolytic anemia Minkowski Chauffard syndrome spherocytic anemia disease_ontology DOID:12971 Xref MGI. hereditary spherocytosis MESH:D018921 NCI:C4062 SNOMEDCT_US_2020_03_01:30419000 UMLS_CUI:C0282548 Leukostasis disease_ontology DOID:12986 leukostasis A leukopenia that is characterized by a severe lack of of granulocytes with a drop in granulocyte concentration below 200 cells/mm³ of blood. ICD10CM:D70 MESH:D000380 SNOMEDCT_US_2020_03_01:154830007 UMLS_CUI:C0001824 Granulocytopenic disorder Granulopenia granulocytopenia disease_ontology DOID:12987 agranulocytosis MESH:D000380 A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated. EFO:0004216 ICD10CM:F91 ICD9CM:312.9 MESH:D019955 NCI:C89329 SNOMEDCT_US_2020_03_01:430909002 UMLS_CUI:C0149654 disease_ontology DOID:12995 conduct disorder MESH:D016893 NCI:C95804 SNOMEDCT_US_2020_03_01:195181000 UMLS_CUI:C0007282 Carotid artery stenosis Stenosis, carotid artery disease_ontology DOID:13001 carotid stenosis ICD9CM:435.2 MESH:D013349 NCI:C35044 SNOMEDCT_US_2020_03_01:15258001 UMLS_CUI:C0038531 Subclavian artery stenosis subclavian steal phenomenon subclavian steal steno-occlusive disease disease_ontology DOID:13002 subclavian steal syndrome ICD10CM:G45.0 ICD9CM:435.3 MESH:D014715 SNOMEDCT_US_2020_03_01:195196001 UMLS_CUI:C0042568 Vertebro-basilar insufficiency Vertebrobasilar arterial insufficiency Vertebrobasilar artery syndrome Vertebrobasilar insufficiency disease_ontology DOID:13003 vertebrobasilar insufficiency MESH:D014715 ICD10CM:B30.0 ICD9CM:077.1 NCI:C34590 SNOMEDCT_US_2020_03_01:60548004 UMLS_CUI:C0014493 EKC Epidemic keratoconjunctivitis disease_ontology DOID:13014 shipyard eye GARD:5695 ICD10CM:H35.1 ICD9CM:362.21 MESH:D012178 NCI:C34982 SNOMEDCT_US_2020_03_01:155110004 UMLS_CUI:C0035344 Retrolental fibroplasia premature retinopathy disease_ontology DOID:13025 retinopathy of prematurity An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories. GARD:8172 ICD10CM:G45.4 ICD9CM:437.7 MESH:D020236 NCI:C85198 SNOMEDCT_US_2020_03_01:366963000 UMLS_CUI:C0338591 disease_ontology DOID:13027 transient global amnesia ICD10CM:N48.1 MESH:D001446 NCI:C26705 SNOMEDCT_US_2020_03_01:155928003 UMLS_CUI:C0004690 disease_ontology DOID:13033 balanitis A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse. ICD10CM:A68 ICD9CM:087 MESH:D012061 SNOMEDCT_US_2020_03_01:186820006 UMLS_CUI:C0035021 disease_ontology DOID:13034 relapsing fever A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy. ICD10CM:A68.1 ICD9CM:087.1 NCI:C34976 SNOMEDCT_US_2020_03_01:10301003 UMLS_CUI:C0035022 Relapsing fever, tick-borne Tick-borne relapsing fever disease_ontology DOID:13036 tick-borne relapsing fever ICD10CM:P29.3 ICD9CM:747.83 MESH:D010547 NCI:C85006 OMIM:265380 SNOMEDCT_US_2020_03_01:35604006 UMLS_CUI:C0031190 Fetal circulation Persistent fetal circulation Persistent fetal circulation syndrome Persistent foetal circulation Persistent foetal circulation syndrome Persistent pulmonary hypertension of the newborn congenital alveolar capillary dysplasia with misalignment of pulmonary veins persistent foetal circulation syndrome persistent pulmonary hypertension of the newborn disease_ontology DOID:13042 OMIM mapping confirmed by DO. [SN]. persistent fetal circulation syndrome ICD10CM:N25.0 ICD9CM:588.0 MESH:D012080 NCI:C114827 SNOMEDCT_US_2020_03_01:266617009 UMLS_CUI:C0035086 renal rickets disease_ontology DOID:13068 renal osteodystrophy A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. ICD9CM:290.8 UMLS_CUI:C0154319 disease_ontology DOID:1307 dementia A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved. DOID:10462 DOID:11399 DOID:11761 DOID:12844 DOID:12845 DOID:12846 DOID:12847 DOID:12848 DOID:13119 DOID:9412 DOID:9690 DOID:9691 ICD9CM:681.9 UMLS_CUI:C0007644 Dermatophytic onychia Dermatophytosis of nail Onychomycosis due to dermatophyte cellulitis and abscess of buttock cellulitis and abscess of face cellulitis and abscess of finger cellulitis and abscess of finger and toe cellulitis and abscess of gluteal region cellulitis and abscess of trunk cellulitis and abscess of upper arm and forearm dermatophytic onychomycosis disease_ontology Tinea unguium cellulitis and abscess DOID:13074 tinea unguium A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules. ICD10CM:B47 MESH:D008271 NCI:C85505 SNOMEDCT_US_2020_03_01:410039003 UMLS_CUI:C0024449 Madura foot Maduromycosis, mycotic Mycotic mycetoma eumycetoma maduromycosis disease_ontology DOID:13078 eumycotic mycetoma GARD:10285 ICD10CM:P91.2 ICD9CM:779.7 MESH:D007969 NCI:C99013 SNOMEDCT_US_2020_03_01:230769007 UMLS_CUI:C0023529 disease_ontology DOID:13088 periventricular leukomalacia MESH:D020765 UMLS_CUI:C0752138 disease_ontology DOID:13089 intracranial arterial disease ICD10CM:H34.23 ICD9CM:362.32 MESH:D015356 NCI:C34436 SNOMEDCT_US_2020_03_01:50821009 UMLS_CUI:C0006123 Arterial retinal branch occlusion Retinal Arterial Branch Occlusion Retinal arterial branch occlusion disease_ontology DOID:13094 branch retinal artery occlusion MESH:D014715 UMLS_CUI:C0042560 Vertebral artery syndrome disease_ontology DOID:13095 vertebral artery insufficiency A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery. ICD10CM:H34.1 ICD9CM:362.31 MESH:D015356 NCI:C34456 SNOMEDCT_US_2020_03_01:38742007 UMLS_CUI:C0007688 disease_ontology DOID:13098 central retinal artery occlusion A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots. GARD:7064 ICD10CM:I67.5 ICD9CM:437.5 MESH:D009072 NCI:C84895 OMIM:252350 OMIM:300845 OMIM:607151 OMIM:608796 OMIM:614042 OMIM:615750 ORDO:2573 ORDO:280679 ORDO:401945 SNOMEDCT_US_2020_03_01:69116000 UMLS_CUI:C0026654 progressive intracranial arterial occlusion disease_ontology DOID:13099 Xref MGI. OMIM mapping confirmed by DO. [SN]. Moyamoya disease MESH:D009072 MESH:D020301 UMLS_CUI:C0751895 disease_ontology DOID:13100 intracranial vasospasm A bladder benign neoplasm that derives_from smooth muscle cells. NCI:C6178 UMLS_CUI:C1332560 leiomyoma of the urinary bladder disease_ontology DOID:13109 bladder leiomyoma ICD9CM:374.04 SNOMEDCT_US_2020_03_01:67383002 UMLS_CUI:C0155191 disease_ontology DOID:13113 cicatricial entropion DOID:3945 EFO:0004236 GARD:6517 MESH:D005923 NCI:C37308 OMIM:PS603278 SNOMEDCT_US_2020_03_01:25821008 UMLS_CUI:C0017668 FGS FSGS focal glomerular sclerosis focal glomerulosclerosis disease_ontology DOID:1312 Xref MGI. OMIM mapping confirmed by DO. [SN]. focal segmental glomerulosclerosis ICD10CM:D53.0 ICD9CM:281.4 SNOMEDCT_US_2020_03_01:85746008 UMLS_CUI:C0154290 Anemia due to protein deficiency Protein-deficiency anaemia Protein-deficiency anemia protein-deficiency anaemia disease_ontology DOID:13120 protein-deficiency anemia ICD9CM:281.9 SNOMEDCT_US_2020_03_01:191125001 UMLS_CUI:C0041782 deficiency anemias disease_ontology DOID:13121 deficiency anemia A childhood spinal muscular atrophy that is a severe form and is characterized by muscle weakness onset from birth to six months of age, the inability to sit unassisted. GARD:7883 ICD10CM:G12.0 ICD9CM:335.0 MESH:D014897 NCI:C98670 OMIM:253300 SNOMEDCT_US_2020_03_01:64383006 UMLS_CUI:C0043116 HMN (Hereditary motor Neuropathy) Proximal type I SMA1 Spinal muscular atrophy 1 hereditary motor neuropathy proximal type I infantile muscular atrophy progressive muscular atrophy of infancy disease_ontology DOID:13137 OMIM mapping confirmed by DO. [SN]. Werdnig-Hoffmann disease ICD9CM:580.0 SNOMEDCT_US_2020_03_01:197579006 UMLS_CUI:C0341692 acute glomerulonephritis with lesion of proliferative glomerulonephritis disease_ontology DOID:13138 acute proliferative glomerulonephritis NCI:C128143 SNOMEDCT_US_2020_03_01:45406000 UMLS_CUI:C0403416 disease_ontology DOID:13139 crescentic glomerulonephritis An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. ICD10CM:H20.9 MESH:D014605 NCI:C26909 SNOMEDCT_US_2020_03_01:267719008 UMLS_CUI:C0042164 disease_ontology DOID:13141 uveitis ICD10CM:H55.04 ICD9CM:379.55 MESH:D009759 SNOMEDCT_US_2020_03_01:9520006 UMLS_CUI:C0155380 Dissociated nystagmus disease_ontology DOID:13174 dissociated nystagmus An arthritis that has_material_basis_in uric acid crystal deposits located_in joint. DOID:14144 EFO:0004274 ICD10CM:M10 ICD9CM:274 ICD9CM:274.0 MESH:D006073 MESH:D015210 NCI:C34650 SNOMEDCT_US_2020_03_01:201661008 SNOMEDCT_US_2020_03_01:90560007 UMLS_CUI:C0003868 UMLS_CUI:C0018099 Articular gout Gouty arthropathy gouty arthritis disease_ontology DOID:13189 gout A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. DOID:2125 DOID:2126 DOID:3543 DOID:6649 DOID:911 ICD10CM:C71 ICD9CM:191 ICD9CM:239.6 MESH:D001932 NCI:C2907 NCI:C3568 NCI:C5115 NCI:C7710 SNOMEDCT_US_2020_03_01:126952004 SNOMEDCT_US_2020_03_01:428061005 SNOMEDCT_US_2020_03_01:93727008 UMLS_CUI:C0006118 UMLS_CUI:C0153633 UMLS_CUI:C0220624 UMLS_CUI:C0750974 UMLS_CUI:C0750979 UMLS_CUI:C1334557 BT - Brain tumour adult brain tumor adult malignant brain neoplasm brain neoplasm brain neoplasm, adult malignant brain tumour malignant primary brain neoplasm malignant primary brain tumor malignant tumor of Brain malignant tumor of adult brain neoplasm of brain primary brain neoplasm primary brain tumor primary malignant neoplasm of brain tumor of the Brain disease_ontology DOID:1319 brain cancer MESH:D006045 SNOMEDCT_US_2020_03_01:66392007 UMLS_CUI:C0018024 Retrosternal thyroid goiter Retrosternal thyroid goitre Substernal goiter Substernal goitre substernal goitre disease_ontology DOID:13200 substernal goiter ICD9CM:362.02 NCI:C84457 SNOMEDCT_US_2020_03_01:154679002 UMLS_CUI:C0154830 PDR disease_ontology DOID:13207 proliferative diabetic retinopathy ICD9CM:426.51 SNOMEDCT_US_2020_03_01:46319007 UMLS_CUI:C0155704 Right bundle branch block with left posterior fascicular block disease_ontology DOID:13209 right bundle branch block An uterine benign neoplasm derived from the smooth muscle layer of the uterus. EFO:0000731 ICD10CM:D25 ICD9CM:218 MESH:D007889 NCI:C3434 OMIM:150699 SNOMEDCT_US_2020_03_01:95315005 UMLS_CUI:C0042133 Plexiform leiomyoma UTERUS FIBROMA leiomyoma of Corpus Uteri uterine leiomyoma disease_ontology DOID:13223 OMIM mapping confirmed by DO. [LS]. uterine fibroid A respiratory system cancer that is located_in the lung. DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 SNOMEDCT_US_2020_03_01:187860004 SNOMEDCT_US_2020_03_01:187864008 SNOMEDCT_US_2020_03_01:187868006 SNOMEDCT_US_2020_03_01:187874006 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493 disease_ontology lung neoplasm DOID:1324 lung cancer ICD10CM:K03.3 ICD9CM:521.4 MESH:D014091 SNOMEDCT_US_2020_03_01:70931000 UMLS_CUI:C0040451 disease_ontology DOID:13240 tooth resorption MESH:D014091 A respiratory system cancer that is located_in the bronchus. ICD10CM:C34 ICD9CM:162.9 SNOMEDCT_US_2020_03_01:187875007 UMLS_CUI:C0348343 malignant neoplasm of bronchus and lung malignant neoplasm of bronchus or lung disease_ontology DOID:1325 bronchus cancer A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea. DOID:0050006 ICD9CM:009.2 MESH:D004403 SNOMEDCT_US_2020_03_01:154268000 UMLS_CUI:C0013369 disease_ontology diarrhea of presumed infectious origin diarrhoea DOID:13250 diarrhea is both a disease and a symptom [ms] diarrhea A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia. DOID:3054 GARD:9564 ICD10CM:A01.0 ICD9CM:002.0 MESH:D014435 NCI:C35089 SNOMEDCT_US_2020_03_01:186091002 UMLS_CUI:C0041466 Typhoid disease_ontology DOID:13258 typhoid fever An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins. GARD:10353 ICD10CM:E80.20 ICD9CM:277.1 MESH:D011164 NCI:C97096 SNOMEDCT_US_2020_03_01:190912004 UMLS_CUI:C0032708 Hematoporphyria Porphyrinopathy disorder of porphyrin and hem metabolism disorder of porphyrin metabolism disease_ontology DOID:13268 porphyria GARD:6619 ICD10CM:E80.29 MESH:D046349 NCI:C84759 OMIM:121300 SNOMEDCT_US_2020_03_01:7425008 UMLS_CUI:C0162531 Coproporphyrinogen oxidase deficiency Hereditary coproporphyria hereditary coproporphyria porphyria disease_ontology DOID:13269 OMIM mapping confirmed by DO. [SN]. hereditary coproporphyria An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue. GARD:4527 ICD10CM:E80.0 MESH:D046351 NCI:C84698 OMIM:177000 OMIM:300752 ORDO:79278 SNOMEDCT_US_2020_03_01:51022005 UMLS_CUI:C0162568 EPP Erythropoietic protoporphyria Protoporphyria disease_ontology DOID:13270 Xref MGI. OMIM mapping confirmed by DO. [SN]. erythropoietic protoporphyria GARD:4446 ICD10CM:E80.0 MESH:D017092 NCI:C84697 OMIM:263700 SNOMEDCT_US_2020_03_01:67312003 UMLS_CUI:C0162530 Erythropoietic porphyria disease_ontology DOID:13271 OMIM mapping confirmed by DO. [SN]. cutaneous porphyria A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites. ICD10CM:A92.4 MESH:D012295 NCI:C128419 SNOMEDCT_US_2020_03_01:7077006 UMLS_CUI:C0035613 disease_ontology DOID:1328 Rift Valley fever A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting. ICD9CM:014.8 UMLS_CUI:C0152724 tuberculosis of intestine disease_ontology DOID:13282 intestinal tuberculosis An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column. GARD:7610 ICD10CM:M42.0 ICD9CM:732.0 MESH:D012544 NCI:C34999 OMIM:181440 SNOMEDCT_US_2020_03_01:53406005 UMLS_CUI:C0036310 Juvenile osteochondritis of the spine Juvenile osteochondrosis of Scheurermann Juvenile osteochondrosis of spine Scheuermann's kyphosis Sherman's Disease Scheuermann disease disease_ontology DOID:13300 OMIM mapping confirmed by DO. [SN]. Scheuermann's disease ICD10CM:K86.81 MESH:D010188 NCI:C84316 SNOMEDCT_US_2020_03_01:47367009 UMLS_CUI:C0267963 Exocrine pancreatic insufficiency disease_ontology DOID:13316 exocrine pancreatic insufficiency A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin. DOID:9996 ICD10CM:E16.9 MESH:D046768 NCI:C4375 SNOMEDCT_US_2020_03_01:42681006 UMLS_CUI:C0027773 Islet cell hyperplasia nesidioblastosis persistent hyperinsulinemia hypoglycemia of infancy disease_ontology DOID:13317 OMIM mapping confirmed by DO. [SN]. hyperinsulinemic hypoglycemia A cataract that is characterized by loss of lens transparency secondary to hyperglycemia related to diabetes mellitus. ICD9CM:366.41 SNOMEDCT_US_2020_03_01:43959009 UMLS_CUI:C0011876 Cataract - diabetic disease_ontology DOID:13328 diabetic cataract A toxoplasmosis that involves a reactivated infection of the mother transmitted to the fetus during pregnancy. Spontaneous abortion and stillbirth may occur. GARD:10326 ICD10CM:P37.1 MESH:D014125 NCI:C50503 SNOMEDCT_US_2020_03_01:268875000 UMLS_CUI:C0040560 Congenital toxoplasmosis Toxoplasmosis - congen. disease_ontology DOID:13336 congenital toxoplasmosis ICD10CM:F65.4 ICD9CM:302.2 MESH:D010378 NCI:C94355 SNOMEDCT_US_2020_03_01:192516001 UMLS_CUI:C0030764 Paedophilia disease_ontology DOID:13351 pedophilia ICD10CM:M22.4 ICD9CM:717.7 MESH:D046789 OMIM:168900 SNOMEDCT_US_2020_03_01:156521009 UMLS_CUI:C0008475 Chondromalacia of patella Chondromalacia patellae softening of articular cartilage of patella disease_ontology DOID:13357 OMIM mapping confirmed by DO. [SN]. chondromalacia patellae A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules. DOID:14696 GARD:6322 ICD10CM:Q79.6 ICD9CM:756.83 MESH:D004535 NCI:C34568 OMIM:PS130000 SNOMEDCT_US_2020_03_01:268352002 UMLS_CUI:C0013720 Cutis hyperelastica elastic skin disease_ontology DOID:13359 OMIM mapping confirmed by DO. [LS]. OMIM mapping by NeuroDevNet. [LS]. Ehlers-Danlos syndrome A learning disability involing difficulty reading resulting primarily from neurological factors which affect any part of the reading process. ICD9CM:315.09 UMLS_CUI:C0154631 disease_ontology DOID:13365 reading disorder A movement disease that is of unknown etiology characterized by progressive rigidity. GARD:5023 ICD10CM:G25.82 ICD9CM:333.91 MESH:D016750 NCI:C85170 OMIM:184850 SNOMEDCT_US_2020_03_01:5217008 UMLS_CUI:C0085292 Stiff-man syndrome stiff man syndrome disease_ontology DOID:13366 Stiff-Person syndrome A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling. ICD10CM:B35.2 ICD9CM:110.2 SNOMEDCT_US_2020_03_01:48971001 UMLS_CUI:C0153246 Dermatophytosis of hand Tinea manus disease_ontology DOID:13369 tinea manuum A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy. ICD10CM:A75.3 ICD9CM:081.2 MESH:D012612 SNOMEDCT_US_2020_03_01:73911003 UMLS_CUI:C0036472 Japanese river fever Kedani fever Scrub mite-borne typhus Tsutsugamushi Tsutsugamushi disease disease_ontology Chigger-borne rickettsiosis Chigger-borne typhus Mite-borne rickettsiosis Mite-borne typhus Scrub (mite-borne) typhus Tropical typhus Tsutsugamushi fever Typhus fever due to Rickettsia tsutsugamushi DOID:13371 scrub typhus A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells. GARD:5784 ICD10CM:E88.01 ICD9CM:273.4 MESH:D019896 NCI:C84397 OMIM:613490 SNOMEDCT_US_2020_03_01:30188007 UMLS_CUI:C0221757 AAT deficiency disease_ontology DOID:13372 OMIM mapping confirmed by DO. [SN]. alpha 1-antitrypsin deficiency MESH:D019896 A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene. GARD:6445 ICD10CM:M61.1 ICD9CM:728.11 MESH:D009221 NCI:C3040 OMIM:135100 ORDO:337 SNOMEDCT_US_2020_03_01:82725007 UMLS_CUI:C0016037 Stone Man Syndrome myositis ossificans progressiva progressive myositis ossificans progressive ossifying myositis disease_ontology DOID:13374 OMIM mapping confirmed by DO. [SN]. fibrodysplasia ossificans progressiva A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities. EFO:0004246 GARD:6816 ICD10CM:M30.3 ICD9CM:446.1 MESH:D009080 NCI:C34825 OMIM:611775 SNOMEDCT_US_2020_03_01:75053002 UMLS_CUI:C0026691 Kawasaki's disease MLNS acute febrile MCLS acute febrile mucocutaneous lymph node syndrome mucocutaneous lymph node syndrome disease_ontology DOID:13378 OMIM mapping confirmed by DO. [SN]. Kawasaki disease A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood. GARD:1999 ICD10CM:D64.4 MESH:D000742 NCI:C84646 OMIM:PS224120 ORDO:85 SNOMEDCT_US_2020_03_01:191272005 UMLS_CUI:C0002876 congenital dyshaematopoietic anaemia disease_ontology DOID:1338 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital dyserythropoietic anemia A nutritional deficiency disease that is characterized by a decrease in red blood cells due to malabsorption of vitamin B12, has_symptom fatigue, pallor, shortness of breath, glossitis, ataxia, and/or paresthesia, has_material_basis_in atrophic gastritis, autoimmune disorder affecting the production or function of intrinsic factor, and/or genetic factors. GARD:12671 ICD10CM:D51.0 ICD9CM:281.0 MESH:D000752 NCI:C2871 OMIM:170900 SNOMEDCT_US_2020_03_01:191139001 UMLS_CUI:C0002892 ANEMIA PERNICIOUS Addison's anaemia Biermer's anaemia Biermer's anemia pernicious anaemia disease_ontology DOID:13381 OMIM mapping confirmed by DO. [SN]. pernicious anemia A macrocytic anemia that is characterized by inhibition of DNA synthesis during red blood cell production. ICD10CM:D53.1 MESH:D000749 NCI:C34382 OMIM:261100 OMIM:613839 SNOMEDCT_US_2020_03_01:191138009 UMLS_CUI:C0002888 Grasbeck-Imerslund syndrome Imerslund-Grasbeck syndrome MGA1 Norwegian type RH-MGA1 megaloblastic anaemia recessive hereditary megaloblastic anaemia 1 recessive hereditary megaloblastic anemia 1 disease_ontology IGS DOID:13382 Xref MGI. megaloblastic anemia A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis_insufficient levels of red blood cells due to bone marrow dysfunction. GARD:6274 ICD10CM:D61.01 MESH:D029503 NCI:C61236 OMIM:PS105650 ORDO:124 SNOMEDCT_US_2020_03_01:188588001 Blackfan - Diamond syndrome chronic constitutional pure red cell anaemia disease_ontology DOID:1339 Xref MGI. OMIM mapping confirmed by DO. [SN]. Diamond-Blackfan anemia A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions. ICD10CM:H53.5 ICD9CM:368.5 MESH:D003117 NCI:C3891 SNOMEDCT_US_2020_03_01:193683001 UMLS_CUI:C0242225 BLINDNESS COLOR Colour blindness Colour vision deficiency disease_ontology DOID:13399 color blindness GARD:7504 MESH:D012010 NCI:C34974 SNOMEDCT_US_2020_03_01:191252000 UMLS_CUI:C0034902 Pure Red cell Aplasia Pure red cell aplasia Red cell hypoplasia primary red cell aplasia disease_ontology DOID:1340 pure red-cell aplasia MESH:D000793 OMIM:607140 UMLS_CUI:C0002982 disease_ontology DOID:13401 OMIM mapping confirmed by DO. [SN]. angioid streaks ICD10CM:D86.3 NCI:C34996 SNOMEDCT_US_2020_03_01:55941000 UMLS_CUI:C0036203 Cutaneous Sarcoidosis Cutaneous sarcoid Cutaneous sarcoidosis disease_ontology DOID:13402 skin sarcoidosis A sarcoidosis that is characterized by conduction abnormalities, arrhythmias, and congestive heart failure with noncaseating granulomas present on endomyocardial biopsy, and develops_from a type IV hypersensitivity reaction with noncaseating granulomas infiltrating the myocardial tissue, especially that of the left ventricle. NCI:C35589 SNOMEDCT_US_2020_03_01:75403004 UMLS_CUI:C0392077 Cardiac sarcoidosis disease_ontology DOID:13405 cardiac sarcoidosis A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood. GARD:10452 ICD10CM:K72 ICD9CM:572.2 MESH:D006501 NCI:C79596 SNOMEDCT_US_2020_03_01:197332007 UMLS_CUI:C0019151 Portal-systemic encephalopathy disease_ontology DOID:13413 hepatic encephalopathy DOID:13639 ICD10CM:D61.0 ICD10CM:D61.01 ICD9CM:284.0 MESH:D029502 SNOMEDCT_US_2020_03_01:191236003 SNOMEDCT_US_2020_03_01:267523003 UMLS_CUI:C0702159 UMLS_CUI:C0949116 congenital aplastic anaemia congenital aplastic anemia congenital hypoplastic anaemia disease_ontology Constitutional aplastic anaemia DOID:1342 congenital hypoplastic anemia DOID:2863 ICD10CM:N34.2 ICD9CM:597.80 MESH:D014526 NCI:C26904 SNOMEDCT_US_2020_03_01:154388003 SNOMEDCT_US_2020_03_01:31822004 UMLS_CUI:C0041976 UMLS_CUI:C0311389 Non-Gonococcal Urethritis Nongonococcal urethritis disease_ontology DOID:1343 urethritis A primary bacterial infectious disease that results in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs. GARD:9536 ICD10CM:A24.0 ICD9CM:024 MESH:D005896 NCI:C34638 SNOMEDCT_US_2020_03_01:4639008 UMLS_CUI:C0017589 Farcy pipes Infection due to Pseudomonas mallei disease_ontology DOID:13444 glanders ICD10CM:I65.1 ICD9CM:433.0 SNOMEDCT_US_2020_03_01:78658006 UMLS_CUI:C0265098 disease_ontology DOID:13446 basilar artery occlusion A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules. DOID:13981 GARD:9525 ICD10CM:B38 ICD9CM:114 MESH:D003047 NCI:C84642 SNOMEDCT_US_2020_03_01:266218008 UMLS_CUI:C0009186 primary extrapulmonary coccidioidomycosis disease_ontology DOID:13450 coccidioidomycosis GARD:12911 ICD10CM:H15.0 ICD9CM:379.00 MESH:D015423 NCI:C119046 SNOMEDCT_US_2020_03_01:155201000 UMLS_CUI:C0036416 disease_ontology DOID:13452 scleritis ICD10CM:N36.42 ICD9CM:599.82 SNOMEDCT_US_2020_03_01:16031000119101 UMLS_CUI:C0375381 Intrinsic (urethral) sphincter deficiency [ISD] disease_ontology DOID:13461 urethral intrinsic sphincter deficiency A balantitis characterized by white plaques or patches on genitals. ICD9CM:607.81 NCI:C3523 SNOMEDCT_US_2020_03_01:198028006 UMLS_CUI:C0152460 Penile Lichen Sclerosus disease_ontology DOID:13477 balanitis xerotica obliterans MESH:D052798 An osteochondrodysplasia that results_in short arms and legs with excess folds of skin. GARD:85 ICD10CM:Q77.1 MESH:D013796 NCI:C85187 OMIM:187600 OMIM:187601 OMIM:273680 ORDO:1860 ORDO:2655 ORDO:93274 ORDO:93275 SNOMEDCT_US_2020_03_01:29352008 UMLS_CUI:C0039743 disease_ontology DOID:13481 Xref MGI. OMIM mapping confirmed by DO. [LS]. thanatophoric dysplasia MESH:D013796 A syndrome that is characterized by overgrowth of the bones, skin, and other tissues. GARD:7475 MESH:D016715 NCI:C85032 OMIM:176920 SNOMEDCT_US_2020_03_01:394527003 UMLS_CUI:C0085261 Wiedemann's syndrome disease_ontology DOID:13482 OMIM mapping confirmed by DO. [SN]. Proteus syndrome A pervasive developmental disorder that is a rare condition characterized by late onset (greater than 3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress. GARD:6040 ICD10CM:F84.3 ICD9CM:299.1 NCI:C97164 SNOMEDCT_US_2020_03_01:71961003 UMLS_CUI:C0236791 Disintegrative psychosis Heller's syndrome Symbiotic psychosis disease_ontology DOID:13487 childhood disintegrative disease ICD10CM:N34.3 ICD9CM:597.81 SNOMEDCT_US_2020_03_01:31273004 UMLS_CUI:C0156279 disease_ontology DOID:13498 urethral syndrome MESH:D010255 NCI:C7488 SNOMEDCT_US_2020_03_01:126675008 UMLS_CUI:C0030470 neoplasm of accessory sinus tumor of Accessory sinus disease_ontology DOID:1350 paranasal sinus benign neoplasm A facial nerve disease characterized by congenital, uni- or bilateral, non-progressive facial weakness and limited abduction of the eye(s). GARD:8549 ICD10CM:Q87.0 MESH:D020331 NCI:C84893 OMIM:157900 SNOMEDCT_US_2020_03_01:89444000 UMLS_CUI:C0221060 Moebius congenital oculofacial paralysis Oromandibular-limb hypogenesis spectrum disease_ontology DOID:13501 OMIM mapping confirmed by DO. [SN]. Mobius syndrome ICD10CM:N30.3 ICD9CM:595.3 NCI:C123175 SNOMEDCT_US_2020_03_01:155885003 UMLS_CUI:C1261278 disease_ontology DOID:13507 trigonitis A syndrome that is characterized by the growth of numerous noncancerous tumors in many parts of the body. GARD:7830 ICD10CM:Q85.1 ICD9CM:759.5 MESH:D014402 NCI:C3424 OMIM:PS191100 SNOMEDCT_US_2020_03_01:157033002 UMLS_CUI:C0041341 Bourneville's disease Epiloia Tuberose sclerosis Tuberous sclerosis syndrome cerebral sclerosis disease_ontology DOID:13515 OMIM mapping confirmed by DO. [LS]. tuberous sclerosis MESH:D010254 NCI:C26843 SNOMEDCT_US_2020_03_01:7393007 UMLS_CUI:C0030469 disorder of nasal sinus disease_ontology DOID:1352 paranasal sinus disease A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has symptom stiff body, has symptom muscle spasms, has symptom difficulty in breathing, and has symptom exhaustion. ICD10CM:A33 ICD9CM:771.3 NCI:C116814 SNOMEDCT_US_2020_03_01:43424001 UMLS_CUI:C0343312 Tetanus neonatorum neonatal tetanus disease_ontology DOID:13521 tetanus neonatorum A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis. GARD:3283 ICD10CM:B74.3 ICD9CM:125.2 MESH:D008118 NCI:C34784 SNOMEDCT_US_2020_03_01:44250009 UMLS_CUI:C0023968 disease_ontology DOID:13523 loiasis An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones. GARD:4155 ICD10CM:Q78.2 ICD9CM:756.52 MESH:D010022 NCI:C26840 OMIM:PS259700 OMIM:PS607634 ORDO:667 SNOMEDCT_US_2020_03_01:205500005 UMLS_CUI:C0029454 Albers-Schonberg disease marble bone disease_ontology DOID:13533 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. osteopetrosis A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body. ICD10CM:E21.3 ICD9CM:252.0 MESH:D006961 NCI:C48259 OMIM:145000 OMIM:145001 OMIM:610071 ORDO:99879 SNOMEDCT_US_2020_03_01:190451000 UMLS_CUI:C0020502 disease_ontology DOID:13543 Xref MGI. hyperparathyroidism An open-angle glaucoma characterized by increased intrinsic resistance to aqueous outflow without known secondary causes, an anatomically narrow anterior chamber angle, or elevated intraocular pressure compared to the average population. Normal tension glaucoma has_symptom progressive decreased vision and progressive loss of peripheral vision. ICD10CM:H40.12 ICD9CM:365.12 MESH:D057066 SNOMEDCT_US_2020_03_01:155124000 UMLS_CUI:C0152136 Normal tension glaucoma disease_ontology DOID:13544 low tension glaucoma A primary angle-closure glaucoma characterized by acute closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes suddenly inappropriately elevated threatening optic nerve damage and visual field loss; but that typically resolves spontaneously after several hours, even though it may recur. Interval angle-closure glaucoma has_symptom sudden pain, redness, headache, and blurry vision with haloes around lights that resolves spontaneously. Interval angle-closure glaucoma can be caused by exacerbation of chronic primary angle-closure glaucoma, typically by a medication or state that dilates the eyes and thus narrows the anterior chamber angle, blocking any aqueous outflow. ICD10CM:H40.23 ICD9CM:365.21 SNOMEDCT_US_2020_03_01:65460003 UMLS_CUI:C0154945 Angle-closure glaucoma, subacute Intermittent angle-closure glaucoma Prodromal angle closure glaucoma disease_ontology DOID:13549 interval angle-closure glaucoma A glaucoma characterized by closure of the anterior chamber angle such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Angle closure glaucoma can be caused by anatomically narrow angle, injury to the trabecular meshwork, and injuries to the anterior chamber, such as neovascularization and uveitis. MESH:D015812 NCI:C34639 SNOMEDCT_US_2020_03_01:270882001 UMLS_CUI:C0017605 ACG - Angle-closure glaucoma Angle Closure Glaucoma Angle-closure glaucoma Closed angle glaucoma Narrow cleft glaucoma primary open-angle glaucoma with narrow angles disease_ontology DOID:13550 angle-closure glaucoma ICD10CM:H47.32 ICD9CM:377.21 MESH:D015594 SNOMEDCT_US_2020_03_01:33629003 UMLS_CUI:C0029128 Drusen of optic disc optic nerve head drusen disease_ontology DOID:13561 optic disk drusen An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system. GARD:5856 ICD10CM:B44 ICD9CM:117.3 MESH:D001228 NCI:C2886 SNOMEDCT_US_2020_03_01:266218008 UMLS_CUI:C0004030 Infection due to Aspergillus disease_ontology DOID:13564 aspergillosis MESH:D001228 ICD10CM:O43.02 MESH:D005330 NCI:C113824 SNOMEDCT_US_2020_03_01:13404009 UMLS_CUI:C2909036 Fetal blood loss from fetal hemorrhage into co-twin Fetal hemorrhage into co-twin Twin to twin transfusion Twin-to-twin blood transfer disease_ontology DOID:13576 twin-to-twin transfusion syndrome A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum. ICD10CM:K83.1 ICD9CM:576.2 MESH:D002779 NCI:C83006 SNOMEDCT_US_2020_03_01:33688009 UMLS_CUI:C0008370 Obstruction of bile duct bile occlusion disease_ontology DOID:13580 cholestasis A pre-eclampsia characterized by the presence of seizures. DOID:13592 GARD:6316 ICD10CM:O15 MESH:D004461 NCI:C87167 SNOMEDCT_US_2020_03_01:156111007 UMLS_CUI:C0013537 Eclampsia in puerperium Eclampsia, postpartum Postpartum eclampsia disease_ontology DOID:13593 eclampsia A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder. GARD:12010 ICD10CM:Q44.2 ICD9CM:751.61 MESH:D001656 NCI:C34421 OMIM:210500 ORDO:30391 SNOMEDCT_US_2020_03_01:77480004 UMLS_CUI:C0005411 Atresia of bile duct Congenital biliary atresia biliary atresia, congenital disease_ontology DOID:13608 biliary atresia NCI:C4419 SNOMEDCT_US_2020_03_01:126678005 UMLS_CUI:C0345672 neoplasm of frontal sinus tumor of the Frontal sinus disease_ontology DOID:1361 frontal sinus benign neoplasm ICD10CM:Q21.1 MESH:D054092 NCI:C34619 SNOMEDCT_US_2020_03_01:268316001 UMLS_CUI:C0016522 Atrial septal defect within oval fossa Defect, Patent or persistent, ostium secundum Ostium secundum type atrial septal defect Persistent ostium secundum foramen ovale patent disease_ontology DOID:13620 patent foramen ovale A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever. DOID:13621 MESH:D002169 SNOMEDCT_US_2020_03_01:86500004 UMLS_CUI:C0006818 Campylobacteriosis disease_ontology DOID:13622 campylobacteriosis ICD10CM:H16.13 ICD9CM:370.24 NCI:C118750 SNOMEDCT_US_2020_03_01:1714005 UMLS_CUI:C0155078 disease_ontology DOID:13626 photokeratitis A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans. ICD10CM:D55.0 MESH:D005236 NCI:C34607 SNOMEDCT_US_2020_03_01:154801000 UMLS_CUI:C0015702 disease_ontology DOID:13628 favism ICD9CM:521.32 UMLS_CUI:C1456162 disease_ontology DOID:13629 dentine erosion A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair. GARD:6425 ICD10CM:D61.09 MESH:D005199 NCI:C62505 OMIM:PS227650 ORDO:84 SNOMEDCT_US_2020_03_01:30575002 UMLS_CUI:C0015625 Fanconi anaemia Fanconi pancytopenia Fanconi panmyelopathy Fanconi's anaemia Fanconi's anemia disease_ontology DOID:13636 Xref MGI. OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS]. Fanconi anemia A phacogenic glaucoma that is characterized by open-angle glaucoma related to deposition of extracellular fibrillar material in anterior segment structures, which blocks aqueous fluid outflow, raises intraocular pressure, and leads to eventual optic nerve atrophy and visual field loss. Exfoliation syndrome has_symptom progressive decreased vision, especially peripheral vision. Exfoliation syndrome is caused by age-related deposition of fibrillar material in anterior segment structures. EFO:0004235 ICD9CM:365.52 MESH:D017889 NCI:C129025 OMIM:177650 SNOMEDCT_US_2020_03_01:111514006 UMLS_CUI:C0206368 Pseudoexfoliation glaucoma Pseudoexfoliation syndrome disease_ontology DOID:13641 OMIM mapping confirmed by DO. [SN]. exfoliation syndrome MESH:D017889 GARD:7606 MESH:D020083 NCI:C119049 SNOMEDCT_US_2020_03_01:60684003 UMLS_CUI:C0263859 Synovitis, acne, pustulosis palmaris, hyperostosis, osteomyelitis syndrome disease_ontology DOID:13677 SAPHO syndrome ICD10CM:F52.4 ICD9CM:302.75 MESH:D061686 NCI:C94349 SNOMEDCT_US_2020_03_01:123302009 UMLS_CUI:C0033038 disease_ontology DOID:13709 premature ejaculation ICD10CM:K00.3 ICD9CM:520.3 MESH:D009050 NCI:C85059 SNOMEDCT_US_2020_03_01:30265004 UMLS_CUI:C0026618 Intrinsic enamel discolouration of fluorosis Mottled teeth Mottling of enamel disease_ontology DOID:13711 dental fluorosis A senile cataract that is characterized by full white or brunescent opacification of the lens of the eye such that the red reflex is obscured. It is a later stage of senile cataracts and is caused by a multifactorial etiology related to aging. SNOMEDCT_US_2020_03_01:193590000 UMLS_CUI:C0152257 Total or mature cataract Total, mature senile cataract disease_ontology DOID:13717 mature cataract A schistosomiasis that involves parasitic infection of the brain and spinal cord by Schistosoma haematobium, Schistosoma mansoni or Schistosoma japonicum causing acute or subacute myelopathy, focal central nervous system impairment, seizures and increased intracranial pressure. MESH:D020818 UMLS_CUI:C0752191 disease_ontology DOID:13722 neuroschistosomiasis A nutritional deficiency disease that is characterized by vitamin C (ascorbic acid) deficiency and has_symptom fatigue, weakness, anemia, petechiae, corkscrew hair, gingivitis, and poor wound healing. GARD:10406 ICD10CM:E54 MESH:D012614 NCI:C35010 OMIM:240400 SNOMEDCT_US_2020_03_01:267493006 UMLS_CUI:C0036474 disease_ontology DOID:13724 OMIM mapping confirmed by DO. [SN]. scurvy A thiamine deficiency disease that is characterized by being severe and chronic. GARD:9948 ICD10CM:E51.1 ICD9CM:265.0 MESH:D001602 NCI:C34418 SNOMEDCT_US_2020_03_01:267491008 UMLS_CUI:C0005122 disease_ontology DOID:13725 beriberi MESH:D001602 An uterine benign neoplasm that has_material_basis_in cells reminiscent of proliferative phase endometrial stroma. NCI:C4262 SNOMEDCT_US_2020_03_01:189810002 UMLS_CUI:C0334485 disease_ontology DOID:1373 endometrial stromal nodule ICD9CM:360.02 MESH:D010202 SNOMEDCT_US_2020_03_01:33382000 UMLS_CUI:C0030332 disease_ontology DOID:13732 panophthalmitis ICD10CM:H04.2 ICD9CM:375.2 MESH:D007766 NCI:C50552 SNOMEDCT_US_2020_03_01:49393005 UMLS_CUI:C0152227 Epiphora Excessive tear production Watering eye disease_ontology DOID:13757 excessive tearing A lice infestation that involves parasitic infestation by pubic lice Pthirus pubis, which are found in the pubic hair, less commonly in eyebrows, eyelashes, beard, mustache, armpit, perianal area, groin, trunk and scalp. The symptoms include itching in the pubic and groin area. Intense itching leads to scratching which can cause sores and secondary bacterial infection of the skin. ICD10CM:B85.3 ICD9CM:132.2 NCI:C35777 SNOMEDCT_US_2020_03_01:71011005 UMLS_CUI:C0030759 Infestation by Phthirus pubis Pediculosis Pubis Pediculus pubis Phthiriasis pubis Phthirus pubis Phthirus/pediculus pubis - pubic lice - crabs crabs disease_ontology DOID:13760 Pthirus pubis infestation A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop. ICD10CM:B66.1 ICD9CM:121.1 MESH:D003003 SNOMEDCT_US_2020_03_01:11938002 UMLS_CUI:C0009021 Oriental liver fluke disease disease_ontology DOID:13767 clonorchiasis A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma. GARD:9746 ICD10CM:B66.0 ICD9CM:121.0 MESH:D009889 SNOMEDCT_US_2020_03_01:187124006 UMLS_CUI:C0029106 Infection by Opisthorchis disease_ontology DOID:13768 opisthorchiasis An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands. GARD:5740 ICD10CM:E27.1 MESH:D000224 NCI:C26689 OMIM:103230 OMIM:240200 SNOMEDCT_US_2020_03_01:363732003 UMLS_CUI:C0001403 Addison disease Addison disease, chronic adrenal insufficiency HYPOADRENOCORTICISM, FAMILIAL primary adrenocortical insufficiency primary hypoadrenalism disease_ontology DOID:13774 Addison's disease A primary immunodeficiency disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body. GARD:6357 MESH:D004819 NCI:C126877 OMIM:PS226400 ORDO:302 SNOMEDCT_US_2020_03_01:19138001 UMLS_CUI:C0014522 disease_ontology DOID:13777 OMIM mapping confirmed by DO. [SN]. epidermodysplasia verruciformis MESH:D004819 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has_material_basis_in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers. GARD:9522 ICD10CM:A57 ICD9CM:099.0 MESH:D002602 SNOMEDCT_US_2020_03_01:154391003 UMLS_CUI:C0007947 Ulcus molle, skin disease_ontology DOID:13778 chancroid ICD10CM:M35.7 ICD9CM:728.5 SNOMEDCT_US_2020_03_01:85551004 UMLS_CUI:C0152093 benign joint hypermobility disease_ontology DOID:13781 hypermobility syndrome ICD10CM:H73.0 ICD9CM:384.00 SNOMEDCT_US_2020_03_01:297009 UMLS_CUI:C0155460 acute myringitis disease_ontology DOID:13790 acute tympanitis A uterine cancer that is located_in tissues lining the uterus. DOID:5654 EFO:0004230 GARD:11981 ICD10CM:C54.1 KEGG:05213 MESH:D016889 NCI:C27815 NCI:C3012 OMIM:608089 SNOMEDCT_US_2020_03_01:123844007 UMLS_CUI:C0007103 UMLS_CUI:C0014170 endometrial Ca endometrial neoplasm malignant endometrial neoplasm malignant neoplasm of endometrium neoplasm of endometrium primary malignant neoplasm of endometrium tumor of Endometrium disease_ontology DOID:1380 endometrial cancer A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus. GARD:6777 ICD10CM:A74.0 ICD9CM:077.0 MESH:D003235 SNOMEDCT_US_2020_03_01:111840005 UMLS_CUI:C0009770 Chlamydial conjunctivitis Inclusion blennorrhoea adult inclusion conjunctivitis inclusion blenorrhea disease_ontology Paratrachoma DOID:13800 inclusion conjunctivitis ICD10CM:E78.49 MESH:D006950 NCI:C35637 OMIM:144250 SNOMEDCT_US_2020_03_01:48190005 UMLS_CUI:C0020474 familial multiple lipoprotein-type hyperlipidemia hyperbetalipoproteinemia with prebetalipoproteinemia mixed hyperlipidaemia type IIb hyperlipoproteinemia disease_ontology DOID:13809 OMIM mapping confirmed by DO. [SN]. familial combined hyperlipidemia A sweat gland disease that is characterized by dilatation of the follicular infundibulum with hyperkeratosis, acanthosis, and spongiosis with perifollicular inflammation leading to hair loss and has_symptom flesh colored papules with hair loss and pruritis, especially of the axilla. GARD:6462 ICD10CM:L75.2 ICD9CM:705.82 MESH:D005588 NCI:C84716 SNOMEDCT_US_2020_03_01:254682006 UMLS_CUI:C0016632 Fox Fordyce disease disease_ontology DOID:1381 Fox-Fordyce disease A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis. GARD:9545 ICD10CM:A55 ICD9CM:099.1 MESH:D008219 NCI:C26822 SNOMEDCT_US_2020_03_01:266213004 UMLS_CUI:C0024286 Climatic or tropical bubo Durand-Nicolas-Favre disease Lymphogranuloma inguinale Poradenitis inguinale Strumous bubo disease_ontology DOID:13819 lymphogranuloma venereum A sweat gland disease that is characterized by blocked eccrine sweat glands and ducts. ICD10CM:L74.3 MESH:D008883 NCI:C34820 SNOMEDCT_US_2020_03_01:63951004 UMLS_CUI:C0026113 eccrine miliaria heat rash sweat rash disease_ontology DOID:1382 miliaria A skin disease located_in the sweat glands. ICD10CM:L74.9 ICD9CM:705.9 MESH:D013543 SNOMEDCT_US_2020_03_01:88232005 UMLS_CUI:C0038986 disease_ontology DOID:1383 sweat gland disease GARD:7342 ICD10CM:Q25.0 ICD9CM:747.0 MESH:D004374 NCI:C84492 OMIM:607411 SNOMEDCT_US_2020_03_01:156928009 UMLS_CUI:C0013274 Patent ductus Botalli disease_ontology ductus arteriosus, Patent DOID:13832 OMIM mapping confirmed by DO. [SN]. patent ductus arteriosus A hypolipoproteinemia that is characterized by an inablility to fully absorb dietary fats, cholesterol and fat-soluble vitamins, has_material_basis_in an autosomal recessive disorder of lipid metabolism that has_material_basis_in mutation in the microsomal triglyceride transfer protein that catalyzes the transport of lipids and is required in the secretion of BETA-LIPOPROTEINS. GARD:5 ICD10CM:E78.6 MESH:D000012 NCI:C84525 OMIM:200100 SNOMEDCT_US_2020_03_01:83123000 UMLS_CUI:C0000744 familial hypobetalipoproteinemia microsomal triglyceride transfer protein deficiency disease disease_ontology DOID:1386 OMIM mapping confirmed by DO. [SN]. abetalipoproteinemia MESH:D000012 A primary angle-closure glaucoma characterized by acute closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes suddenly inappropriately elevated threatening futher optic nerve damage and visual field loss. Acute closed-angle glaucoma has_symptom sudden pain, redness, headache, and blurry vision with haloes around lights. Acute closed-angle glaucoma can be caused by exacerbation of chronic primary angle-closure glaucoma, typically by a medication or state that dilates the eyes and thus narrows the anterior chamber angle, blocking any aqueous outflow. ICD10CM:H40.21 ICD9CM:365.22 SNOMEDCT_US_2020_03_01:30041005 UMLS_CUI:C0154946 acute angle-closure glaucoma disease_ontology DOID:13862 acute closed-angle glaucoma ICD10CM:G52.7 ICD9CM:352.6 SNOMEDCT_US_2020_03_01:78152008 UMLS_CUI:C0154733 Multiple cranial nerve palsies Multiple cranial nerve palsy disease_ontology DOID:13866 multiple cranial nerve palsy ICD10CM:F52.0 ICD9CM:302.71 MESH:D020018 NCI:C94337 SNOMEDCT_US_2020_03_01:78889008 UMLS_CUI:C0020594 Lack or loss of sexual desire disease_ontology DOID:13868 hypoactive sexual desire disorder GARD:8394 ICD10CM:E78.6 ICD9CM:272.5 MESH:D007009 SNOMEDCT_US_2020_03_01:363140000 UMLS_CUI:C0020623 Hypolipoproteinaemia disease_ontology Lipoprotein deficiencies DOID:1387 hypolipoproteinemia GARD:7731 ICD10CM:E78.6 MESH:D013631 NCI:C85182 OMIM:205400 SNOMEDCT_US_2020_03_01:190783007 UMLS_CUI:C0039292 familial alpha-lipoprotein deficiency familial high density lipoprotein deficiency familial hypoalphalipoproteinemia disease_ontology DOID:1388 OMIM mapping confirmed by DO. [LS]. Tangier disease MESH:D013631 ICD10CM:I49.5 MESH:D012804 NCI:C62244 OMIM:163800 OMIM:608567 ORDO:166282 SNOMEDCT_US_2020_03_01:266307005 UMLS_CUI:C0037052 sinus node infection disease_ontology DOID:13884 Xref MGI. sick sinus syndrome MESH:D012804 A peripheral system disease that is characterized by damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain. ICD10CM:A69.22 MESH:D011115 NCI:C26951 SNOMEDCT_US_2020_03_01:193166009 UMLS_CUI:C0152025 disease_ontology DOID:1389 polyneuropathy MESH:D010212 NCI:C3712 SNOMEDCT_US_2020_03_01:63451008 UMLS_CUI:C0205874 Epidermoid papilloma disease_ontology DOID:139 squamous cell papilloma A hypolipoproteinemia characterized by permanently low levels of apolipoprotein B and LDL cholesterol resulting from an impaired ability to absorb and transport fats. MESH:D006995 SNOMEDCT_US_2020_03_01:190786004 UMLS_CUI:C0020597 Hypo-beta-lipoproteinemia disease_ontology DOID:1390 hypobetalipoproteinemia ICD10CM:E78.6 MESH:D007863 NCI:C84813 OMIM:245900 SNOMEDCT_US_2020_03_01:238091006 UMLS_CUI:C0023195 LECITHIN:CHOLESTEROL ACYLTRANSFERASE DEFICIENCY lecithin acyltransferase deficiency disease_ontology DOID:1391 OMIM mapping confirmed by DO. [SN]. Norum disease ICD9CM:368.51 MESH:D003117 OMIM:303900 SNOMEDCT_US_2020_03_01:51445007 UMLS_CUI:C0155015 Protan defect Protanopia disease_ontology DOID:13910 red color blindness A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance. ICD10CM:H53.51 ICD9CM:368.54 MESH:D003117 NCI:C84528 ORDO:49382 SNOMEDCT_US_2020_03_01:56852002 UMLS_CUI:C0152200 ACHM Monochromatism disease_ontology DOID:13911 achromatopsia ICD10CM:H52.21 ICD9CM:367.22 SNOMEDCT_US_2020_03_01:47099006 UMLS_CUI:C0152194 disease_ontology DOID:13919 irregular astigmatism ICD9CM:377.24 MESH:C562401 OMIM:177800 SNOMEDCT_US_2020_03_01:57138009 UMLS_CUI:C0155300 disease_ontology DOID:1392 OMIM mapping confirmed by DO. [SN]. pseudopapilledema An esophagitis characterized by inflammation involving eosinophils located_in esophagus. EFO:0004232 ICD10CM:K20.0 ICD9CM:530.13 MESH:D057765 NCI:C27105 OMIM:610247 OMIM:613412 ORDO:73247 SNOMEDCT_US_2020_03_01:235599003 UMLS_CUI:C0341106 disease_ontology DOID:13922 Xref MGI. OMIM mapping confirmed by DO. [SN]. eosinophilic esophagitis MESH:D007767 NCI:C34757 SNOMEDCT_US_2020_03_01:95769009 UMLS_CUI:C0022906 Blocked lacrimal canaliculus Obstruction of lacrimal canaliculus Obstruction of lacrimal ducts disease_ontology DOID:13929 lacrimal duct obstruction An eye disease that affects the neural pathway from the optic nerve to the visual cortex, through which light is interpreted as an image. ICD10CM:H47.9 NCI:C35342 SNOMEDCT_US_2020_03_01:54767005 UMLS_CUI:C0155287 disease_ontology DOID:1393 visual pathway disease ICD10CM:G51.0 MESH:D005158 NCI:C26769 SNOMEDCT_US_2020_03_01:90039006 UMLS_CUI:C0015469 Facial Palsy disease_ontology DOID:13934 facial paralysis A female reproductive system disease that is characterized by the absence of menstruation. ICD10CM:N91.2 ICD9CM:626.0 MESH:D000568 NCI:C61443 SNOMEDCT_US_2020_03_01:156034000 UMLS_CUI:C0002453 absence of menstruation amenia disease_ontology DOID:13938 amenorrhea MESH:D000568 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer. ICD9CM:120.0 MESH:D012553 NCI:C39294 SNOMEDCT_US_2020_03_01:60979006 UMLS_CUI:C0276926 Schistosoma Hematobium Infection Schistosoma haematobium Schistosoma hematobium infectious disease Schistosomiasis due to schistosoma haematobium Schistosomiasis of bladder Vesical schistosomiasis bladder Schistosomiasis cystitis with bilharziasis disease_ontology Schistosoma haematobium infection DOID:1394 urinary schistosomiasis ICD9CM:386.11 MESH:D065635 OMIM:193007 OMIM:613106 SNOMEDCT_US_2020_03_01:111541001 UMLS_CUI:C0155502 benign paroxysmal positional vertigo disease_ontology DOID:13941 Xref MGI. OMIM mapping confirmed by DO. [SN]. benign paroxysmal positional nystagmus A leukodystrophy characterized by recurrent subcortical ischemic stroke and cognitive impairment. GARD:1049 ICD10CM:I67.850 MESH:D046589 NCI:C84606 OMIM:600142 OMIM:PS125310 ORDO:136 SNOMEDCT_US_2020_03_01:390723008 UMLS_CUI:C0751587 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy hereditary multi-infarct dementia disease_ontology DOID:13945 CADASIL ICD10CM:N32.0 ICD9CM:596.0 MESH:D001748 NCI:C79541 SNOMEDCT_US_2020_03_01:197859007 UMLS_CUI:C0005694 Obstruction of bladder neck or vesicourethral orifice disease_ontology DOID:13948 bladder neck obstruction GARD:6787 MESH:D018856 NCI:C27189 SNOMEDCT_US_2020_03_01:197834003 UMLS_CUI:C0282488 ulcerative cystitis disease_ontology DOID:13949 interstitial cystitis A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria. GARD:9687 ICD9CM:120.8 SNOMEDCT_US_2020_03_01:187116001 UMLS_CUI:C0029827 disease_ontology DOID:1395 schistosomiasis A senile cataract that is characterized by dense white opacification of the lens and milky fluid in the lens capsule such that the dense nucleus of the lens sinks in the surrounding fluid. It is the late stage of senile cataracts and is caused by a multifactorial etiology related to aging. ICD9CM:366.18 SNOMEDCT_US_2020_03_01:247065006 UMLS_CUI:C0152258 hypermature cataract disease_ontology DOID:13964 Morgagni cataract A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host. DOID:11681 DOID:13509 DOID:1396 DOID:1494 DOID:2114 DOID:2293 DOID:2922 DOID:3564 DOID:4191 DOID:886 DOID:948 DOID:9639 DOID:9644 ICD10CM:H44.12 ICD9CM:360.13 NCI:C34587 SNOMEDCT_US_2020_03_01:57100005 UMLS_CUI:C0014238 Ectoparasitic disease parasitemia disease_ontology DOID:1398 parasitic infectious disease An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in undeveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull. GARD:6118 ICD10CM:Q74.0 MESH:D002973 NCI:C75020 OMIM:119600 OMIM:216330 ORDO:1452 SNOMEDCT_US_2020_03_01:65976001 UMLS_CUI:C0008928 Marie-Sainton Disease cleidocranial dysostosis disease_ontology DOID:13994 Xref MGI. OMIM mapping confirmed by DO. [SN]. cleidocranial dysplasia NCI:C4007 SNOMEDCT_US_2020_03_01:449074003 UMLS_CUI:C0278805 small intestinal Lymphoma disease_ontology DOID:13996 small intestine lymphoma An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye. ICD10CM:H04 ICD9CM:375 MESH:D007766 NCI:C26809 SNOMEDCT_US_2020_03_01:267740009 UMLS_CUI:C0022904 disease_ontology DOID:1400 lacrimal apparatus disease ICD9CM:442.83 SNOMEDCT_US_2020_03_01:70405009 UMLS_CUI:C0155747 disease_ontology DOID:14006 splenic artery aneurysm ICD10CM:K70.3 ICD9CM:571.2 MESH:D008104 NCI:C34782 SNOMEDCT_US_2020_03_01:420054005 UMLS_CUI:C0023891 Alcoholic Cirrhosis Alcoholic cirrhosis of liver Laennec's cirrhosis Laennec's cirrhosis, alcoholic Portal cirrhosis disease_ontology DOID:14018 alcoholic liver cirrhosis A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has_material_basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines. ICD10CM:D52 ICD9CM:281.2 SNOMEDCT_US_2020_03_01:85649008 UMLS_CUI:C0151482 Folate deficiency anaemia Folate deficiency anemia Folate-deficiency anaemia Folate-deficiency anemia Folate-deficient megaloblastic anaemia folic acid deficiency anaemia disease_ontology DOID:14026 folic acid deficiency anemia A blood protein disease that is characterized by polyneuropathy, oranomegaly, endocrinopathy, monoclonal gammopathy, and skin changes, especially hyperpigmentation. GARD:7411 MESH:D016878 NCI:C80303 SNOMEDCT_US_2020_03_01:79268002 UMLS_CUI:C0085404 disease_ontology DOID:14039 POEMS syndrome An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. ICD10CM:E31.0 MESH:D016884 NCI:C84576 SNOMEDCT_US_2020_03_01:41864002 UMLS_CUI:C0085409 Autoimmune polyglandular failure Lloyd's syndrome autoimmune polyendocrinopathy disease_ontology DOID:14040 autoimmune polyendocrine syndrome A bipolar disorder that is characterized by at least one manic or mixed episode. ICD9CM:296.50 SNOMEDCT_US_2020_03_01:49468007 UMLS_CUI:C0236773 disease_ontology DOID:14042 bipolar I disorder A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals. GARD:12803 MESH:D060446 Infection by dematiacious fungi phaehyphomycosis disease_ontology DOID:14049 phaeohyphomycosis An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component. ICD10CM:H40.2 ICD9CM:365.2 SNOMEDCT_US_2020_03_01:193544008 UMLS_CUI:C0017606 primary Angle Closure Glaucoma disease_ontology DOID:1405 primary angle-closure glaucoma MESH:D007500 NCI:C50621 SNOMEDCT_US_2020_03_01:65074000 UMLS_CUI:C0022081 disease_ontology DOID:1406 iritis NCI:C35443 SNOMEDCT_US_2020_03_01:68544003 UMLS_CUI:C0403414 Post-Streptococcal Glomerulonephritis disease_ontology DOID:14064 acute poststreptococcal glomerulonephritis NCI:C35587 SNOMEDCT_US_2020_03_01:197585004 UMLS_CUI:C0341689 acute Diffuse Glomerulonephritis disease_ontology DOID:14066 acute diffuse nephritis A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax. ICD9CM:084.8 MESH:D001742 NCI:C34426 SNOMEDCT_US_2020_03_01:56625005 UMLS_CUI:C0005681 Black water fever Blackwater fever Hemoglobinuric, malaria Malarial Hemoglobinuria disease_ontology DOID:14068 blackwater fever GARD:10941 MESH:D014606 NCI:C35109 SNOMEDCT_US_2020_03_01:193500005 UMLS_CUI:C0042165 disease_ontology DOID:1407 anterior uveitis ICD9CM:379.54 SNOMEDCT_US_2020_03_01:46888001 UMLS_CUI:C0155379 Nystagmus associated with disorder of the vestibular system disease_ontology DOID:14070 vestibular nystagmus A bone inflammation disease that results_in inflammation located_in epicondyle. DOID:14162 ICD10CM:M77.1 ICD9CM:726.32 MESH:D013716 NCI:C34589 NCI:C35067 SNOMEDCT_US_2020_03_01:156659008 SNOMEDCT_US_2020_03_01:268088003 UMLS_CUI:C0014488 UMLS_CUI:C0039516 Lateral epicondylitis andrel epicondylitis archer's elbow golfer's elbow hockey elbow medial epicondylitis disease_ontology shooter's elbow tennis elbow DOID:14087 epicondylitis ICD9CM:521.08 MESH:D017213 SNOMEDCT_US_2020_03_01:30512007 UMLS_CUI:C0162644 Cementum caries Dental caries of root surface Root caries disease_ontology DOID:14089 root caries A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities. DOID:0050039 DOID:0050040 DOID:0050044 DOID:0050045 ICD10CM:A77.1 ICD9CM:082.1 MESH:D001907 SNOMEDCT_US_2020_03_01:186779000 UMLS_CUI:C0006060 African tick typhus Rickettsia conorii spotted fever South African tick-bite fever african tick typhus kenya tick typhus marseilles fever disease_ontology Boutonneuse disease Conor and Bruch's disease Kenya fever Kenyan tick typhus Mediterranean spotted fever Mediterranean tick fever DOID:14095 boutonneuse fever A large intestine cancer that is located_in the anus. DOID:12240 GARD:9300 ICD10CM:C21.0 ICD10CM:C21.1 ICD9CM:154.2 ICD9CM:154.3 NCI:C7379 SNOMEDCT_US_2020_03_01:93669004 SNOMEDCT_US_2020_03_01:93676009 UMLS_CUI:C0153445 UMLS_CUI:C0153446 anal cancer malignant anal tumor disease_ontology DOID:14110 anus cancer ICD10CM:K14.2 ICD9CM:529.2 SNOMEDCT_US_2020_03_01:7522008 UMLS_CUI:C0155963 Persistent tuberculum impar disease_ontology DOID:14111 median rhomboid glossitis A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities. ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 SNOMEDCT_US_2020_03_01:18504008 UMLS_CUI:C0600327 TSS Toxic Shock syndrome Toxic shock syndrome toxic shock disease_ontology DOID:14115 toxic shock syndrome A familial hyperlipemia characterized by a deficiency of the enzyme lipoprotein lipase and the subsequent build up of chylomicrons and increased plasma concentration of triglycerides. GARD:12241 ICD10CM:E78.3 ICD9CM:272.3 MESH:D008072 NCI:C84771 OMIM:238600 ORDO:309015 SNOMEDCT_US_2020_03_01:34171006 UMLS_CUI:C0023817 Fredrickson type I hyperlipoproteinemia Fredrickson type I lipaemia familial LPL deficiency familial chylomicronemia syndrome familial hyperlipoproteinemia type I hypercholesterinaemic xanthomatosis hyperchylomicronemia mixed hyperglyceridemia disease_ontology DOID:14118 OMIM mapping confirmed by DO. [SN]. familial lipoprotein lipase deficiency A urinary system disease which consists of the presence of bacteria in urine. ICD10CM:R82.71 MEDDRA:10004056 MESH:D001437 SNOMEDCT_US_2020_03_01:61373006 UMLS_CUI:C0004659 disease_ontology DOID:1412 bacteriuria A prolapse of the female genital organ that is characterized by the descent of the bladder causing a bulge in the anterolateral vaginal walls. ICD10CM:N81.12 ICD9CM:618.02 SNOMEDCT_US_2020_03_01:441891001 UMLS_CUI:C2711750 disease_ontology DOID:14130 lateral cystocele A female reproductive system disease that is characterized by an excessively mobile uterus secondary to lacerations of the broad and cardinal ligaments, specific tenderness with movement of the cervix and previous untoward obstetrics events, such as premature maternal voluntary efforts, precipate delivery, and forceps delivery. ICD9CM:620.6 SNOMEDCT_US_2020_03_01:69186005 UMLS_CUI:C0152079 Broad ligament laceration syndrome disease_ontology DOID:14133 Masters-Allen syndrome An ovarian disease that is characterized by irregular or absent ovulation. ICD9CM:256.3 SNOMEDCT_US_2020_03_01:267399006 UMLS_CUI:C0029697 disease_ontology DOID:1414 ovarian dysfunction An ureteral disease this is characterized by the formation of stoney concentrations in the ureter. ICD10CM:N20.1 ICD9CM:592.1 MESH:D053039 NCI:C114696 SNOMEDCT_US_2020_03_01:31054009 UMLS_CUI:C0041952 Ureteric calculus Ureteric stone calculus of ureter disease_ontology DOID:14146 ureterolithiasis GARD:6556 MESH:D015799 NCI:C84744 OMIM:258870 SNOMEDCT_US_2020_03_01:314467007 UMLS_CUI:C0018425 Gyrate atrophy of the choroid and/or retina Ornithinemia with gyrate atrophy gyrate atrophy of the retina disease_ontology DOID:1415 OMIM mapping by NeuroDevNet. [LS]. gyrate atrophy ICD10CM:H31.9 ICD9CM:363.9 MESH:D015862 NCI:C34468 SNOMEDCT_US_2020_03_01:193480005 UMLS_CUI:C0008521 disease_ontology DOID:1417 choroid disease MESH:D018306 NCI:C3791 SNOMEDCT_US_2020_03_01:302832007 UMLS_CUI:C0206719 Neurolipocytoma disease_ontology DOID:14174 central neurocytoma GARD:7855 ICD10CM:Q85.8 MESH:D006623 NCI:C3105 OMIM:193300 SNOMEDCT_US_2020_03_01:46659004 UMLS_CUI:C0019562 Hippel Lindau syndrome Von Hippel-Lindau syndrome von Hippel-Lindau syndrome disease_ontology DOID:14175 OMIM mapping confirmed by DO. [LS]. von Hippel-Lindau disease ICD9CM:279.04 SNOMEDCT_US_2020_03_01:190983003 UMLS_CUI:C1457897 Congenital hypogammaglobulinaemia Congenital hypogammaglobulinemia disease_ontology DOID:14177 congenital hypogammaglobulinemia An agammaglobulinemia that is that has_material_basis_in a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. MESH:C537409 NCI:C3822 OMIM:300755 ORDO:47 SNOMEDCT_US_2020_03_01:65880007 UMLS_CUI:C0221026 BTK deficiency Bruton agammaglobulinemia tyrosine kinase deficiency Bruton's Sex-Linked Agammaglobulinemia Bruton's agammaglobulinaemia Bruton's type agammaglobulinemia Bruton-type agammaglobulinemia disease_ontology DOID:14179 OMIM mapping confirmed by DO. [SN]. X-linked agammaglobulinemia ICD10CM:M75.3 ICD9CM:726.11 SNOMEDCT_US_2020_03_01:239957000 UMLS_CUI:C0158303 disease_ontology DOID:14181 calcific tendinitis ICD10CM:G62.1 ICD9CM:357.5 MESH:D020269 NCI:C26926 SNOMEDCT_US_2020_03_01:7916009 UMLS_CUI:C0085677 Alcohol-related polyneuropathy Alcoholic polyneuropathy disease_ontology DOID:14183 alcoholic neuropathy MESH:D020269 A connective tissue disease characterized by restriction of both active and passive range of motion located_in the scapulohumeral joint and has_symptom pain and has_symptom restricted range of motion. ICD10CM:M75.0 ICD9CM:726.0 MESH:D002062 SNOMEDCT_US_2020_03_01:156664007 UMLS_CUI:C0311223 Adhesive capsulitis of shoulder adhesions-capsulitis,shoulder disease_ontology DOID:14188 frozen shoulder adult onset dermatomyositis disease_ontology DOID:14202 adult dermatomyositis A syndrome characterized by disruption of mineralization of bones and teeth that has_material_basis_in mutation in ALPL on chromosome 1p36.12. DOID:14763 GARD:6734 ICD10CM:E83.39 MESH:C562440 MESH:D007014 NCI:C26798 ORDO:436 SNOMEDCT_US_2020_03_01:30174008 SNOMEDCT_US_2020_03_01:70848009 UMLS_CUI:C0020630 UMLS_CUI:C0220743 childhood hypophosphatasia deficiency of alkaline phosphatase hypophospatasia, childhood disease_ontology DOID:14213 OMIM mapping confirmed by DO. [SN]. hypophosphatasia A purine-pyrimidine metabolic disorder that is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine. GARD:19 MESH:D054067 NCI:C84672 OMIM:274270 SNOMEDCT_US_2020_03_01:238016000 UMLS_CUI:C1959620 UMLS_CUI:C3495551 Dihydropyrimidine dehydrogenase deficiency Dihydrouracil Dehydrogenase deficiency familial pyrimidinaemia thymine-uracilurea disease_ontology DOID:14218 dihydropyrimidine dehydrogenase deficiency A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine. GARD:7552 ICD10CM:N25.89 MESH:D000141 NCI:C28129 OMIM:179830 OMIM:267200 OMIM:602722 SNOMEDCT_US_2020_03_01:1776003 UMLS_CUI:C0001126 disease_ontology DOID:14219 Xref MGI. renal tubular acidosis An abdominal obesity-metabolic syndrome characterized by insulin resistance and hyperinsulinemia, dyslipidemia, essential hypertension, abdominal obesity, glucose intolerance or noninsulin-dependent diabetes mellitus and an increased risk of cardiovascular events. EFO:0000195 GARD:9226 ICD10CM:E88.81 ICD9CM:277.7 MESH:D024821 NCI:C84442 OMIM:605552 SNOMEDCT_US_2020_03_01:190394009 UMLS_CUI:C0524620 abdominal obesity-metabolic syndrome 1 dysmetabolic syndrome X metabolic syndrome X disease_ontology DOID:14221 OMIM mapping confirmed by DO. [SN]. abdominal obesity-metabolic syndrome 1 A connective tissue disease characterized by bluish-brown discoloration of connective tissues that develops from the deposition of homogentisic acid and subsequent oxidation and polymerization reactions. GARD:7231 ICD10CM:E70.29 MESH:D009794 NCI:C84938 SNOMEDCT_US_2020_03_01:21924005 UMLS_CUI:C0028817 disease_ontology DOID:14223 ochronosis A frontal sinusitis which lasts for less than 4 weeks. ICD10CM:J01.1 ICD9CM:461.1 SNOMEDCT_US_2020_03_01:155500003 UMLS_CUI:C0155805 disease_ontology DOID:14225 acute frontal sinusitis A male infertility disease characterized by the absence of any measurable level of sperm in semen. EFO:0000279 ICD10CM:N46.0 ICD9CM:606.0 MESH:D053713 NCI:C80076 ORDO:217034 SNOMEDCT_US_2020_03_01:425558002 UMLS_CUI:C0004509 spermatogenic failure disease_ontology DOID:14227 Xref MGI. azoospermia MESH:D053713 A male fertility issue defined as a low sperm concentration in the ejaculate. ICD10CM:N46.1 ICD9CM:606.1 MESH:D009845 NCI:C34860 UMLS_CUI:C0028960 disease_ontology DOID:14228 oligospermia A scleral disease that is characterized by a painless severe necrotizing scleritis where the sclera is white, avascular, and thin. The choroid can become exposed leading to infarction and necrosis of related areas; the sclera can also thin such that the dark uvea protrudes through the front of the eye, forming a staphyloma which has_symptom loss of vision and appearance of a dark bulge. Scleromalacia perforans is usually caused by a rare complication of autoimmune disease like rheumatoid arthritis. ICD10CM:H15.05 ICD9CM:379.04 SNOMEDCT_US_2020_03_01:26664005 UMLS_CUI:C0155354 disease_ontology DOID:14230 scleromalacia perforans A suppurative otitis media which is persistent and long-lasting. ICD10CM:H66.3 ICD9CM:382.3 NCI:C128386 SNOMEDCT_US_2020_03_01:38394007 UMLS_CUI:C0271454 chronic suppurative otitis media disease_ontology DOID:14247 chronic purulent otitis media A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability. GARD:10247 ICD10CM:Q90 ICD9CM:758.0 MESH:D004314 NCI:C2993 OMIM:190685 ORDO:870 SNOMEDCT_US_2020_03_01:41040004 UMLS_CUI:C0013080 Complete trisomy 21 syndrome Down's syndrome Down's syndrome - trisomy 21 Downs syndrome G Trisomy trisomy 21 syndrome disease_ontology DOID:14250 OMIM mapping confirmed by DO. [SN]. Down syndrome ICD10CM:H35.51 ICD9CM:362.73 SNOMEDCT_US_2020_03_01:79556007 UMLS_CUI:C0154863 Vitreoretinal dystrophies disease_ontology DOID:14251 vitreoretinal dystrophy A rheumatoid arthritis that is characterized by high fevers, rash, sore throat and joint pain. GARD:436 ICD10CM:M06.1 MESH:D016706 SNOMEDCT_US_2020_03_01:239920006 UMLS_CUI:C0085253 adult onset Still's disease adult-onset Still disease disease_ontology DOID:14256 adult-onset Still's disease A urinary system disease that is located_in the ureter. MESH:D014515 UMLS_CUI:C0041954 disease_ontology DOID:1426 ureteral disease A syndrome that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function. GARD:6464 ICD10CM:Q99.2 ICD9CM:759.83 MESH:D005600 NCI:C84717 OMIM:300624 ORDO:908 SNOMEDCT_US_2020_03_01:390007001 UMLS_CUI:C0016667 FRAGILE X MENTAL RETARDATION SYNDROME MARKER X SYNDROME MARTIN-BELL SYNDROME disease_ontology DOID:14261 OMIM mapping confirmed by DO. [SN]. fragile X syndrome A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion. MESH:D020936 NCI:C84593 OMIM:121200 OMIM:121201 OMIM:269720 ORDO:1949 SNOMEDCT_US_2020_03_01:38281008 UMLS_CUI:C0270851 benign familial neonatal seizures benign neonatal convulsions disease_ontology DOID:14264 Xref MGI. benign neonatal seizures A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur. DOID:11210 MESH:D011665 NCI:C51447 SNOMEDCT_US_2020_03_01:91434003 UMLS_CUI:C0034088 Pulmonic insufficiency Pulmonic valve regurgitation pulmonary incompetence pulmonary incompetence, non-rheumatic pulmonary insufficiency following trauma and surgery pulmonary regurg. pulmonary regurgitation disease_ontology DOID:14265 Replacing outdated UMLS CUI. pulmonary valve insufficiency MESH:D011665 EFO:0004268 ICD10CM:K83.09 MESH:D015209 SNOMEDCT_US_2020_03_01:4032000 UMLS_CUI:C0008313 fibrosing cholangitis disease_ontology DOID:14268 sclerosing cholangitis ICD10CM:K83.09 NCI:C35372 SNOMEDCT_US_2020_03_01:26918003 UMLS_CUI:C0311273 Ascending Cholangitis Ascending cholangitis disease_ontology DOID:14270 ascending cholangitis ICD10CM:E16 ICD9CM:251 SNOMEDCT_US_2020_03_01:190427005 UMLS_CUI:C0154189 disease_ontology DOID:1428 endocrine pancreas disease ICD10CM:M89.4 MESH:D010004 NCI:C85023 OMIM:259100 SNOMEDCT_US_2020_03_01:88220006 UMLS_CUI:C0029411 Pachydermoperiostosis of nail Pachydermoperiostosis syndrome disease_ontology DOID:14283 OMIM mapping confirmed by DO. [SN]. primary hypertrophic osteoarthropathy MESH:D046788 UMLS_CUI:C0877149 disease_ontology DOID:14284 patellofemoral pain syndrome A tricuspid valve disease that is a congenital heart defect in which the septal leaflet of the tricuspid valve is displaced towards the apex of the right ventricle of the heart. GARD:6313 ICD10CM:Q22.5 ICD9CM:746.2 MESH:D004437 NCI:C84681 OMIM:224700 SNOMEDCT_US_2020_03_01:1796006 UMLS_CUI:C0013481 Ebstein's anomaly Ebstein's anomaly of common atrioventricular valve Ebstein's anomaly of right atrioventricular valve Ebstein's anomaly of tricuspid valve disease_ontology DOID:14289 OMIM mapping confirmed by DO. [SN]. Ebstein anomaly A RASopathy that is characterized by autosomal dominant inheritance of brown skin spots called lentigines that are similar to freckles, heart defects, widely spaced eyes a sunken chest or protruding chest and short stature. GARD:1100 MESH:D044542 NCI:C84820 OMIM:PS151100 ORDO:500 SNOMEDCT_US_2020_03_01:111306001 UMLS_CUI:C0175704 Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome Generalized lentiginosis Gorlin syndrome II LEOPARD syndrome Lentiginosis profusa syndrome Moynahan syndrome Multiple lentigines syndrome Progressive cardiomyopathic lentiginosis disease_ontology DOID:14291 OMIM mapping confirmed by DO. [SN]. Noonan syndrome with multiple lentigines A pleural empyema which involves presence of pus in the pleural cavity and calcified visceral pleura. It results from a large number of mycobacteria spilling into the pleural space, usually from rupture of a cavity or an adjacent paranchymal focus via a bronchopleural fistula. MESH:D004654 NCI:C34575 SNOMEDCT_US_2020_03_01:186184002 UMLS_CUI:C0014014 Tuberculous empyema disease_ontology DOID:14305 tuberculous empyema An eye disease characterized by a lack or loss of vision. ICD10CM:H54 ICD9CM:369 SNOMEDCT_US_2020_03_01:193698004 UMLS_CUI:C0155020 vision impairment vision loss visual impairment disease_ontology DOID:1432 blindness An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation. ICD10CM:F41.1 ICD9CM:300.02 NCI:C92622 SNOMEDCT_US_2020_03_01:192401002 UMLS_CUI:C0270549 disease_ontology DOID:14320 generalized anxiety disorder A connective tissue disease that is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens. GARD:6975 ICD10CM:Q87.4 ICD9CM:759.82 MESH:D008382 NCI:C34807 OMIM:154700 SNOMEDCT_US_2020_03_01:19346006 UMLS_CUI:C0024796 Marfan's syndrome disease_ontology DOID:14323 OMIM mapping confirmed by DO. [SN]. Marfan syndrome MESH:D008382 A malaria that involves infection with more than one species of Plasmodium at the same time. ICD9CM:084.5 SNOMEDCT_US_2020_03_01:21070001 UMLS_CUI:C0153121 Malaria fever by more than one parasite malaria by more than one parasite disease_ontology DOID:14325 mixed malaria A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. EFO:0002508 GARD:10251 ICD10CM:G20 ICD9CM:332 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 SNOMEDCT_US_2020_03_01:49049000 UMLS_CUI:C0030567 Parkinson disease paralysis agitans disease_ontology DOID:14330 Xref MGI. OMIM mapping confirmed by DO. [SN]. Parkinson's disease ICD10CM:E06.0 MESH:D013969 NCI:C129724 SNOMEDCT_US_2020_03_01:3511005 UMLS_CUI:C0040150 Infectious thyroiditis Suppurative thyroiditis acute suppurative thyroiditis disease_ontology DOID:14350 suppurative thyroiditis ICD10CM:H18.71 ICD9CM:371.71 SNOMEDCT_US_2020_03_01:14748007 UMLS_CUI:C0155135 disease_ontology DOID:1436 corneal ectasia An amino acid metabolic disorder that involves defective proteins called carnitine transporters, which bring carnitine into cells and prevent its escape from the body preventing the body cannot utilize fats for energy. DOID:1668 ICD10CM:E71.41 ICD9CM:277.81 MESH:C536778 NCI:C98864 OMIM:212140 SNOMEDCT_US_2020_03_01:21764004 UMLS_CUI:C0342788 carnitine transporter deficiency carnitine uptake defect deficiency of plasma-membrane carnitine transporter primary carnitine deficiency renal carnitine transport defect disease_ontology DOID:14365 OMIM mapping confirmed by DO. [SN]. systemic primary carnitine deficiency disease A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching. NCI:C34855 SNOMEDCT_US_2020_03_01:128870005 UMLS_CUI:C0028425 Crusted scabies disease_ontology DOID:14374 norwegian scabies ICD10CM:R82.81 MESH:D011776 NCI:C119028 SNOMEDCT_US_2020_03_01:4800001 UMLS_CUI:C0034359 Pus cells in urine disease_ontology DOID:1439 pyuria An autosomal dominant cerebellar ataxia that is characterized by slow degeneration of the hindbrain and has_material_basis_in expansion of CAG triplet repeats (glutamine) in the ATXN3 gene. MESH:D017827 NCI:C84830 OMIM:109150 SNOMEDCT_US_2020_03_01:91952008 UMLS_CUI:C0024408 Azorean disease MJD SCA3 spinocerebellar ataxia 3 spinocerebellar ataxia type 3 disease_ontology DOID:1440 OMIM mapping confirmed by DO. [SN]. Machado-Joseph disease MESH:D017827 MESH:D019559 NCI:C62578 SNOMEDCT_US_2020_03_01:87730004 UMLS_CUI:C0343084 Capillary leak syndrome disease_ontology DOID:14400 capillary leak syndrome MESH:D019559 A cerebellar ataxia that has_material_basis_in autosomal dominant inheritance. DOID:2478 MESH:D020754 NCI:C82341 OMIM:PS164400 ORDO:94 SNOMEDCT_US_2020_03_01:129609000 UMLS_CUI:C0087012 spinocerebellar ataxia disease_ontology DOID:1441 autosomal dominant cerebellar ataxia An osteochondrosis that results_in death and fracture located_in hip joint. DOID:14561 GARD:6874 ICD10CM:M91.2 MESH:D007873 NCI:C34766 OMIM:150600 SNOMEDCT_US_2020_03_01:15739006 SNOMEDCT_US_2020_03_01:270545000 UMLS_CUI:C0022441 UMLS_CUI:C0023234 Calve - Perthes' disease Coxa plana Juvenile osteochond-hip/pelvis Juvenile osteochondrosis of hip and/or pelvis Perthe's disease Perthes disease Pseudocoxalgia juvenile osteochondrosis of hip and pelvis osteochondrosis of Legg-Calve-Perthes pseudocoxalgia disease_ontology Legg-Calve-Perthes symptom DOID:14415 OMIM mapping confirmed by DO. [SN]. Legg-Calve-Perthes disease A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection. GARD:6286 ICD10CM:B72 ICD9CM:125.7 MESH:D004320 NCI:C84677 SNOMEDCT_US_2020_03_01:48874008 UMLS_CUI:C0013100 Dracontiasis Infection by Dracunculus medinensis disease_ontology DOID:14418 dracunculiasis GARD:6519 ICD10CM:G52.1 ICD9CM:352.1 MESH:D020435 SNOMEDCT_US_2020_03_01:43763009 UMLS_CUI:C0154731 Glossopharyngeal neuralgia disease_ontology DOID:14423 glossopharyngeal neuralgia A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue. GARD:6019 ICD9CM:331.9 SNOMEDCT_US_2020_03_01:52522001 UMLS_CUI:C0154671 Brain degeneration disease_ontology DOID:1443 cerebral degeneration A physical urticaria induced by sweating. ICD10CM:L50.5 ICD9CM:708.5 SNOMEDCT_US_2020_03_01:73098005 UMLS_CUI:C0152230 disease_ontology DOID:14443 cholinergic urticaria A deep keratitis that is characterized by inflammation of the anterior sclera and subsequent inflammation of the adjacent cornea with opacification of the corneal stroma and has_symptom pain, red eyes, photophobia, tearing, and blurry vision. Sclerosing keratitis is caused by severe anterior scleritis that causes inflammation and injury to the adjacent corneal layer. Anterior scleritis can be caused by autoimmune diseases, connective tissue diseases, and infection. ICD10CM:H16.33 ICD9CM:370.54 SNOMEDCT_US_2020_03_01:27886001 UMLS_CUI:C0155090 Sclerokeratitis disease_ontology DOID:14444 sclerosing keratitis A disorder of sexual development that is characterized by a progressive loss of germ cells on the developing gonads of an embryo. GARD:2538 ICD9CM:758.6 MESH:D006059 NCI:C61420 SNOMEDCT_US_2020_03_01:268356004 UMLS_CUI:C0018051 Gonadal dysgenesis syndrome disease_ontology DOID:14447 gonadal dysgenesis A gonadal dysgenesis that is characterized by progressive loss of primordial cells on the developing glands of an embryo, leading to extremely hypoplastic and dysfuctioning gonads resulting in one differentiated gonad and either a streak gonad or streak testis. MESH:D006060 NCI:C120199 SNOMEDCT_US_2020_03_01:205682006 UMLS_CUI:C0018055 disease_ontology DOID:14449 mixed gonadal dysgenesis GARD:195 ICD10CM:G72.3 MESH:D020513 NCI:C123429 OMIM:170500 ORDO:682 SNOMEDCT_US_2020_03_01:304737009 UMLS_CUI:C0238357 familial hyperkalemic periodic paralysis disease_ontology DOID:14451 OMIM mapping confirmed by DO. [SN]. hyperkalemic periodic paralysis GARD:5557 GARD:6729 ICD10CM:G72.3 MESH:D020514 NCI:C84775 OMIM:170400 OMIM:613345 ORDO:681 SNOMEDCT_US_2020_03_01:240093008 UMLS_CUI:C0238358 Hypokalemic familial periodic paralysis Hypokalemic periodic paralysis Periodic paralysis I Westphal disease familial hypokalemic periodic paralysis familial periodic paralysis periodic hypokalemic paralysis disease_ontology DOID:14452 OMIM mapping confirmed by DO. [SN]. hypokalemic periodic paralysis An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness. GARD:6427 ICD10CM:J67.0 ICD9CM:495.0 MESH:D005203 NCI:C34605 SNOMEDCT_US_2020_03_01:155581001 UMLS_CUI:C0015634 Farmers lung farmer lung disease_ontology DOID:14453 farmer's lung A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers. GARD:7195 ICD10CM:G21.0 ICD9CM:333.92 MESH:D009459 NCI:C94829 ORDO:94093 SNOMEDCT_US_2020_03_01:15244003 UMLS_CUI:C0027849 disease_ontology DOID:14464 neuroleptic malignant syndrome A viral infectious disease that results in infection located in lung, has_material_basis_in Sin Nombre virus, transmitted by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted by rice rat (Oligoryzomys longicaudatus). The infection has _ymptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications. GARD:69 MESH:D018804 NCI:C84747 SNOMEDCT_US_2020_03_01:120639003 UMLS_CUI:C0243025 disease_ontology DOID:14472 hantavirus pulmonary syndrome A vesiculobullous skin disease that is characterized by erythematous papules, vesicles, and plaques around the trunk and extremities that develop during pregnancy, particularly during the second and third trimesters, has_symptom pruritis, and has_material_basis_in autoantibodies to the basement membrane, which triggers a complement cascade and attracts eosinophils to the subepidermis. ICD10CM:O26.4 MESH:D006559 NCI:C85003 SNOMEDCT_US_2020_03_01:86081009 UMLS_CUI:C0019343 Gestational herpes herpes gestationis disease_ontology DOID:14482 pemphigoid gestationis A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation. GARD:7692 ICD10CM:B42 ICD9CM:117.1 MESH:D013174 SNOMEDCT_US_2020_03_01:266218008 UMLS_CUI:C0038034 disease_ontology DOID:14484 sporotrichosis ICD10CM:K91.1 MESH:D004377 NCI:C2994 SNOMEDCT_US_2020_03_01:155785007 UMLS_CUI:C0013288 Dumping (jejunal) syndrome Jejunal syndrome disease_ontology DOID:14495 dumping syndrome GARD:7899 ICD10CM:E75.5 MESH:D015223 NCI:C61271 SNOMEDCT_US_2020_03_01:82500001 UMLS_CUI:C0043208 Acid esterase deficiency Acid lipase deficiency Wolman xanthomatosis Wolman's disease Wolman's or triglyceride storage type III disease Xanthomatosis, familial disease_ontology DOID:14497 Wolman disease GARD:3268 MESH:D008065 NCI:C84829 OMIM:247100 SNOMEDCT_US_2020_03_01:38692000 UMLS_CUI:C0023795 Lipid proteinosis Lipoid proteinosis URBACH-WIETHE DISEASE disease_ontology DOID:14498 OMIM mapping confirmed by DO. [SN]. lipoid proteinosis A sphingolipidosis that is characterized by the buildup of globotriaosylceramide in the body's cells and has_material_basis_in X-linked inherited mutations in the GLA gene, encoding alpha-galactosidase A, on chromosome Xq22. GARD:6400 ICD10CM:E75.21 MESH:D000795 NCI:C84701 OMIM:301500 SNOMEDCT_US_2020_03_01:16652001 UMLS_CUI:C0002986 Alpha-galactosidase A deficiency Angiokeratoma Corporis Diffusum Fabry's disease alpha galactosidase deficiency deficiency of melibiase disease_ontology DOID:14499 OMIM mapping confirmed by DO. [SN]. Fabry disease GARD:6473 ICD10CM:E77.1 MESH:D005645 NCI:C61274 OMIM:230000 SNOMEDCT_US_2020_03_01:64716005 UMLS_CUI:C0016788 A-fucosidase deficiency alpha fucosidase deficiency disease_ontology DOID:14500 OMIM mapping confirmed by DO. [SN]. fucosidosis MESH:D015217 SNOMEDCT_US_2020_03_01:57218003 UMLS_CUI:C0008384 disease_ontology DOID:14502 cholesterol ester storage disease MESH:D015217 GARD:10739 ICD10CM:E75.4 MESH:D009472 NCI:C61257 OMIM:PS256730 ORDO:216 ORDO:79262 SNOMEDCT_US_2020_03_01:42012007 UMLS_CUI:C0027877 hereditary ceroid lipofuscinosis disease_ontology DOID:14503 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. neuronal ceroid lipofuscinosis A sphingoliidosis characterized by the accumulation of the lipid sphingomyelin in lysosomes in cells. DOID:0050442 DOID:0050443 DOID:14770 GARD:13334 ICD10CM:E75.24 MESH:D009542 NCI:C61269 SNOMEDCT_US_2020_03_01:58459009 UMLS_CUI:C0028064 Sphingomyelinase Deficiency Disease lipoid histiocytosis sphingomyelin lipidosis disease_ontology DOID:14504 OMIM mapping confirmed by DO. [SN]. Niemann-Pick disease A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes. GARD:5528 MESH:D017624 NCI:C3718 OMIM:194072 SNOMEDCT_US_2020_03_01:715215007 UMLS_CUI:C0206115 11p partial monosomy syndrome Wilms tumor-Aniridia-Genitourinary Anomalies-Mental Retardation syndrome chromosome 11p13 deletion syndrome disease_ontology DOID:14515 OMIM mapping confirmed by DO. [LS]. WAGR syndrome A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use. GARD:7570 ICD10CM:G93.7 ICD9CM:331.81 MESH:D012202 NCI:C34983 SNOMEDCT_US_2020_03_01:74351001 UMLS_CUI:C0035400 Reye's syndrome disease_ontology DOID:14525 Reye syndrome MESH:D012391 UMLS_CUI:C0035851 disease_ontology DOID:14550 root resorption A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling. ICD10CM:I27.0 ICD9CM:416.0 NCI:C97119 OMIM:178600 OMIM:265400 OMIM:615342 OMIM:615343 OMIM:615344 ORDO:422 SNOMEDCT_US_2020_03_01:26174007 UMLS_CUI:C0152171 disease_ontology DOID:14557 Xref MGI. OMIM mapping confirmed by DO. [SN]. primary pulmonary hypertension ICD10CM:K14.0 ICD9CM:529.0 MESH:D005928 NCI:C112199 SNOMEDCT_US_2020_03_01:155666003 UMLS_CUI:C0017675 disease_ontology DOID:1456 glossitis A disease that is characterized by abnormally rapid cell division. neoplasm DOID:0000818 cell process disease neoplasm disease_ontology DOID:14566 disease of cellular proliferation A thyroid gland disease which involves an underproduction of thyroid hormone. DOID:11630 EFO:0004705 ICD10CM:E03.9 ICD9CM:244.9 MESH:D007037 NCI:C26800 SNOMEDCT_US_2020_03_01:267465007 UMLS_CUI:C0020676 Thyroid deficiency Thyroid insufficiency disease_ontology DOID:1459 hypothyroidism GARD:7318 ICD10CM:H47.1 ICD9CM:377.0 MESH:D010211 NCI:C3307 SNOMEDCT_US_2020_03_01:423341008 UMLS_CUI:C0030353 disease_ontology DOID:146 papilledema ICD10CM:N41.9 ICD9CM:601.9 MESH:D011472 NCI:C26866 SNOMEDCT_US_2020_03_01:155907007 UMLS_CUI:C0033581 disease_ontology DOID:14654 prostatitis A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency. GARD:2015 GARD:5724 MESH:C538179 OMIM:101800 OMIM:614613 ORDO:950 SNOMEDCT_US_2020_03_01:66758006 UMLS_CUI:C0220659 disease_ontology DOID:14669 OMIM mapping confirmed by DO. [SN]. acrodysostosis An intestinal disease characterized by the presence of numerous atresic segments in the small and large intestines that has_material_basis_in homozygous or compound heterozygous mutation in TTC7A on chromosome 2p21. GARD:3013 MESH:C562441 OMIM:243150 ORDO:2300 SNOMEDCT_US_2020_03_01:95472001 UMLS_CUI:C0220744 GIDID MEDDRA:10028210 Multiple gastrointestinal atresias familial intestinal polyatresia syndrome gastrointestinal defects and immunodeficiency syndrome disease_ontology DOID:14671 OMIM mapping confirmed by DO. [SN]. multiple intestinal atresia A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities. GARD:5443 ICD10CM:Q87.2 MESH:C536534 OMIM:192350 OMIM:276950 SNOMEDCT_US_2020_03_01:205830006 UMLS_CUI:C0220708 disease_ontology VATER syndrome DOID:14679 OMIM mapping confirmed by DO. [LS]. VACTERL association An otitis interna which involves inflammation of the labyrinths. ICD10CM:H83.0 ICD9CM:386.3 MESH:D007762 SNOMEDCT_US_2020_03_01:155239008 UMLS_CUI:C0022893 disease_ontology DOID:1468 labyrinthitis A physical disorder that is characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. GARD:4870 ICD10CM:Q87.19 MESH:D056730 NCI:C85068 OMIM:180860 SNOMEDCT_US_2020_03_01:15069006 UMLS_CUI:C0175693 Silver Russell Dwarfism disease_ontology DOID:14681 OMIM mapping confirmed by DO. [LS]. Silver-Russell syndrome An eye disease characterized by abnormalities of the front part of the eye, the anterior segment. GARD:5701 ICD10CM:Q13.81 NCI:C131001 ORDO:782 SNOMEDCT_US_2020_03_01:47507006 UMLS_CUI:C0265341 Anomaly, Rieger's Axenfeld syndrome RGS - Rieger syndrome Rieger's anomaly disease_ontology Hagedoom syndrome DOID:14686 Xref MGI. OMIM mapping confirmed by DO. [SN]. Axenfeld-Rieger syndrome An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism. GARD:6275 ICD10CM:Q77.5 MESH:C536170 NCI:C156311 OMIM:222600 SNOMEDCT_US_2020_03_01:58561002 UMLS_CUI:C0220726 disease_ontology DOID:14687 OMIM mapping confirmed by DO. [SN]. diastrophic dysplasia DOID:4366 GARD:5683 ICD10CM:E78.72 MESH:D019082 NCI:C85071 OMIM:270400 SNOMEDCT_US_2020_03_01:43929004 UMLS_CUI:C0175694 Rutledge lethal multiple congenital anomaly syndrome Smith-Opitz-Inborn syndrome disease_ontology DOID:14692 OMIM mapping confirmed by DO. [LS]. Smith-Lemli-Opitz syndrome GARD:2056 MESH:D004476 OMIM:129500 SNOMEDCT_US_2020_03_01:54209007 UMLS_CUI:C0162361 Clouston's hidrotic ectodermal dysplasia Clouston's syndrome Hidrotic ectodermal dysplasia syndrome ectodermal dysplasia 2, Clouston type hidrotic ectodermal dysplasia disease_ontology DOID:14693 OMIM mapping confirmed by DO. [SN]. Clouston syndrome A syndrome that involves abnormal development of the pancreas, nose and scalp, with mental retardation, hearing loss and growth failure. It is inherited in an autosomal recessive manner. GARD:80 MESH:C535880 OMIM:243800 ORDO:2315 SNOMEDCT_US_2020_03_01:75979009 UMLS_CUI:C0175692 JBS disease_ontology DOID:14694 OMIM mapping confirmed by DO. [SN]. Johanson-Blizzard syndrome A galactosemia that involves an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase. GARD:2422 ICD10CM:E74.29 MESH:D005693 NCI:C114767 OMIM:230200 SNOMEDCT_US_2020_03_01:124302001 UMLS_CUI:C0268155 Galactosemia II disease_ontology DOID:14695 OMIM mapping confirmed by DO. [SN]. galactokinase deficiency A chromosomal deletion syndrome that is characterized by absence of the radius bone and platelet deficiency and bilateral absence of the radii with the presence of both thumbs and generally transient thrombocytopenia (less than 50 platelets/nL) and that has_material_basis_in compound heterozygosity for a rare null mutation involving the RBM8A gene on chromosome 1q12 on 1 allele and 1 of 2 low-frequency noncoding single-nucleotide polymorphisms in RBM8A on the other. ICD10CM:Q87.2 MESH:C536940 NCI:C99038 OMIM:274000 ORDO:3320 SNOMEDCT_US_2020_03_01:85589009 UMLS_CUI:C0175703 Radial aplasia-thrombocytopenia syndrome Thrombocytopenia with absent radii (TAR) syndrome chromosome 1q21.1 deletion syndrome disease_ontology DOID:14699 OMIM mapping confirmed by DO. [LS]. thrombocytopenia-absent radius syndrome An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities. DOID:10614 DOID:2240 DOID:2241 DOID:7580 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.3 NCI:C34796 OMIM:608520 OMIM:608691 SNOMEDCT_US_2020_03_01:268621008 SNOMEDCT_US_2020_03_01:36923009 UMLS_CUI:C0024517 UMLS_CUI:C0154409 recurrent major depression single major depressive episode disease_ontology DOID:1470 Xref MGI. major depressive disorder An organic acidemia that involes a nonfunctional propionyl CoA carboxylase affecting conversion of aminio acids and fats into sugar for energy. DOID:14706 GARD:467 ICD10CM:E71.121 MESH:D056693 NCI:C85030 OMIM:606054 SNOMEDCT_US_2020_03_01:69080001 UMLS_CUI:C0268579 UMLS_CUI:C2717876 GLYCINEMIA, KETOTIC KETOTIC HYPERGLYCINEMIA ketotic II glycinemia ketotic glycinemia propionic aciduria propionyl-CoA carboxylase deficiency disease_ontology DOID:14701 OMIM mapping confirmed by DO. [SN]. propionic acidemia A syndrome characterized by branchial arch anomalies (branchial fistulas, clefts, or cysts), hearing impairment, structural defects of the outer, middle, and inner ear, and renal abnormalities. GARD:10147 MEDDRA:10071135 MESH:D019280 NCI:C98983 SNOMEDCT_US_2020_03_01:290006 UMLS_CUI:C0265234 Branchio-Oto-renal syndrome Branchio-otorenal dysplasia Melnick-Fraser syndrome branchiootorenal dysplasia disease_ontology DOID:14702 OMIM mapping confirmed by DO. [SN]. branchiootorenal syndrome A syndrome characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern. GARD:2317 MESH:C537923 OMIM:300321 OMIM:300406 OMIM:300422 OMIM:300581 OMIM:305450 ORDO:323 ORDO:93932 SNOMEDCT_US_2020_03_01:49984004 UMLS_CUI:C0220769 Keller syndrome Opitz-Kaveggia syndrome disease_ontology DOID:14711 Xref MGI. OMIM mapping confirmed by DO. [SN]. FG syndrome A myopathy characterized by abnormally located nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery. GARD:101 MESH:D020914 NCI:C84648 ORDO:595 ORDO:596 ORDO:69186 ORDO:69189 SNOMEDCT_US_2020_03_01:193223007 UMLS_CUI:C0175709 myotubular myopathy disease_ontology DOID:14717 Xref MGI. centronuclear myopathy An amino acid metabolic disorder characterized by inability to process isoleucine and ketones, has_symptom recurrent ketoacidotic attacks in infancy marked by vomitting, lethargy, dehydration, and seizures, and has_material_basis_in mutation in the ACAT1 gene of chromosome 11q22.3 responsible for producing the ACAT1 enzyme in mitochondria, which processes isoleucine and ketones. GARD:872 MESH:C535818 OMIM:203750 ORDO:134 SNOMEDCT_US_2020_03_01:238067002 UMLS_CUI:C1533628 2-methyl-3-hydroxybutyricacidemia 3-ketothiolase deficiency 3-oxothiolase deficiency Mitochondrial acetoacetyl-CoA Thiolase deficiency alpha-methylacetoaceticaciduria peroxisomal thiolase deficiency disease_ontology DOID:14723 OMIM mapping confirmed by DO. [SN]. beta-ketothiolase deficiency A microcephaly that has_material_basis_in heterozygous mutation in an autosomal gene. MESH:C537323 OMIM:156580 UMLS_CUI:C0220693 disease_ontology DOID:14725 OMIM mapping confirmed by DO. [SN]. autosomal dominant microcephaly A syndrome that is characterized by prenatal and postnatal overgrowth, accelerated osseous maturation, characteristic craniofacial appearance, and developmental delay and has_material_basis_in heterozygous mutation in the EZH2 gene on chromosome 7q36. GARD:5545 GARD:7878 MESH:C562443 OMIM:277590 UMLS_CUI:C0220765 WEAVER-LIKE SYNDROME Weaver-Williams syndrome disease_ontology DOID:14731 OMIM mapping confirmed by DO. [LS]. Weaver syndrome A syndrome that has_material_basis_in mutation in the EFNB1 gene on chromosome Xq13 and is characterized in hemizygous males by hypertelorism and with greater severity in females by frontonasal dysplasia, craniofacial asymmetry, craniosynostosis, bifid nasal tip, grooved nails, wiry hair, and abnormalities of the thoracic skeleton. GARD:1578 MESH:C536456 OMIM:304110 ORDO:1520 SNOMEDCT_US_2020_03_01:715421009 UMLS_CUI:C0220767 CFND CFNS craniofrontonasal dysostosis craniofrontonasal dysplasia disease_ontology DOID:14737 OMIM mapping confirmed by DO. [SN]. craniofrontonasal syndrome A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium. ICD10CM:K05.2 MESH:D010520 OMIM:170650 OMIM:608526 SNOMEDCT_US_2020_03_01:449908004 UMLS_CUI:C0031106 juvenile periodontitis disease_ontology DOID:1474 OMIM mapping confirmed by DO. [SN]. aggressive periodontitis MESH:D010520 A syndrome that is characterized by short stature, sparse hair, a bulbous nasal tip and cone-shaped epiphyses (the growing ends of bones), as well as severe generalized shortening of all finger and toe bones (brachydactyly). DOID:0050552 MESH:C536820 NCI:C75109 OMIM:190350 SNOMEDCT_US_2020_03_01:239016009 UMLS_CUI:C0432233 trichorhinophalangeal syndrome type 1 type I trichorhinophalangeal syndrome disease_ontology Trichorhinophalangeal dysplasia type I DOID:14743 OMIM mapping confirmed by DO. [LS]. trichorhinophalangeal syndrome type I A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria. GARD:4235 MESH:C562446 OMIM:309510 ORDO:94083 UMLS_CUI:C0220775 X-linked Russell-Silver syndrome disease_ontology DOID:14744 OMIM mapping confirmed by DO. [SN]. OMIM mapping submitted by NeuroDevNet. [LS]. Partington syndrome A syndrome that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life. GARD:10091 ICD10CM:Q87.3 MESH:D058495 NCI:C75019 OMIM:PS117550 ORDO:821 SNOMEDCT_US_2020_03_01:75968004 UMLS_CUI:C0175695 cerebral gigantism disease_ontology DOID:14748 Xref MGI. Sotos syndrome An organic acidemia that involves an accumulation of methylmalonic acid in the blood. DOID:14782 DOID:14802 GARD:7033 methylmalonic aciduria disease_ontology DOID:14749 OMIM mapping confirmed by DO. [SN]. methylmalonic acidemia A benign vascular tumor that is composed of dilated lymphatic channels. GARD:9789 ICD10CM:D18.1 ICD9CM:228.1 MESH:D008202 NCI:C8965 SNOMEDCT_US_2020_03_01:154625006 UMLS_CUI:C0024221 Congenital lymphangioma benign lymphangioma disease_ontology DOID:1475 lymphangioma An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine. GARD:465 ICD10CM:E71.110 MESH:C538167 NCI:C98964 OMIM:243500 SNOMEDCT_US_2020_03_01:87827003 UMLS_CUI:C0268575 Isovaleryl-CoA dehydrogenase deficiency isovaleric acid CoA dehydrogenase deficiency isovaleric aciduria disease_ontology DOID:14753 OMIM mapping confirmed by DO. [SN]. isovaleric acidemia An amino acid metabolic disorder that involves the accumulation of argininosuccinic acid (ASA) in the blood and urine. GARD:5843 MESH:D056807 NCI:C84569 OMIM:207900 SNOMEDCT_US_2020_03_01:41013004 UMLS_CUI:C0268547 Argininosuccinate lyase deficiency argininosuccinic acidemia arginosuccinase deficiency deficiency of argininosuccinate lyase disease_ontology DOID:14755 OMIM mapping confirmed by DO. [SN]. argininosuccinic aciduria A synostosis characterized by the fusion of carpal and tarsal bones, which causes stiffness and immobility of the hands and the feet. OMIM:186400 SNOMEDCT_US_2020_03_01:62628008 UMLS_CUI:C0175700 Multiple synostosis syndrome SYNOSTOSES, TARSAL, CARPAL AND DIGITAL disease_ontology DOID:14762 OMIM mapping confirmed by DO. [LS]. calcaneonavicular coalition Asyndrome that is characterized by autosomal dominant inheritance of large-joint dislocations and characteristic craniofacial abnormalities. GARD:6860 OMIM:150250 dominant larsen syndrome disease_ontology DOID:14764 OMIM mapping confirmed by DO. [SN]. Larsen syndrome A renal disease that is characterized by the failure of one or both kidneys to develop. GARD:9228 OMIM:191830 ORDO:93108 hereditary renal aplasia hereditary urogenital adysplasia renal adysplasia renal aplasia disease_ontology DOID:14766 renal agenesis An ectodermal dysplasia characterized by short-limbed short stature and fine, sparse hair that has_material_basis_in homozygous or compound heterozygous mutation in RMRP on chromosome 9p13.3. DOID:0080022 MESH:C535916 NCI:C61245 OMIM:250250 SNOMEDCT_US_2020_03_01:234421004 UMLS_CUI:C0220748 CHH McKusick type metaphyseal chondrodysplasia Metaphyseal chondrodysplasia, McKusick type disease_ontology DOID:14773 OMIM mapping confirmed by DO. [SN]. cartilage-hair hypoplasia A syndrome characterized by blepharophimosis, ptosis, epicanthus inversus, and telecanthus with (type I) or without (premature ovarian failure) that has_material_basis_in heterozygous or rarely homozygous mutation in FOXL2 on chromosome 3q22.3. MESH:C562419 OMIM:110100 SNOMEDCT_US_2020_03_01:79833006 UMLS_CUI:C0220663 disease_ontology Blepharophimosis, ptosis, epicanthus inversus syndrome DOID:14778 OMIM mapping confirmed by DO. [SN]. blepharophimosis, ptosis, and epicanthus inversus syndrome A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton. GARD:82 MESH:C537015 OMIM:148050 ORDO:2332 SNOMEDCT_US_2020_03_01:711156009 UMLS_CUI:C0220687 disease_ontology DOID:14780 OMIM mapping confirmed by DO. [SN]. KBG syndrome DOID:0080025 GARD:4987 OMIM:183900 Late Spondyloepiphyseal Dysplasia disease_ontology DOID:14789 OMIM mapping confirmed by DO. [SN]. spondyloepiphyseal dysplasia congenita A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness. GARD:634 MESH:D057130 NCI:C129075 OMIM:PS204000 ORDO:65 SNOMEDCT_US_2020_03_01:193413001 UMLS_CUI:C0339527 LCA Leber's amaurosis Leber's congenital amaurosis Leber's disease disease_ontology DOID:14791 Xref MGI. OMIM mapping confirmed by DO. [SN]. Leber congenital amaurosis An ectodermal dysplasia that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). DOID:0050446 DOID:0050447 GARD:76 MESH:D053358 NCI:C84562 OMIM:129490 OMIM:224900 OMIM:300291 OMIM:305100 ORDO:238468 SNOMEDCT_US_2020_03_01:239007005 UMLS_CUI:C0162359 Christ-Siemens-Touraine Syndrome Ectodermal Dysplasia 1, Anhydrotic Hypohidrotic X-linked ectodermal dysplasia anhidrotic ectodermal dysplasia 3 disease_ontology DOID:14793 OMIM mapping confirmed by DO. [SN]. hypohidrotic ectodermal dysplasia A syndrome that is characterized by microcephaly, growth retardation and a characteristic facial appearance including but not limited to narrow or triangular shaped head, micrognathia, ptosis, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids. GARD:6290 ICD10CM:Q87.19 MEDDRA:10059589 MESH:C535718 NCI:C125591 OMIM:223370 SNOMEDCT_US_2020_03_01:2593002 UMLS_CUI:C0175691 Dubowitz's syndrome disease_ontology DOID:14796 OMIM mapping confirmed by DO. [SN]. Dubowitz syndrome A periodontal disease that is located_in the gums. MESH:D005882 SNOMEDCT_US_2020_03_01:18718003 UMLS_CUI:C0017563 gum disease disease_ontology DOID:1483 gingival disease A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs. DOID:12447 DOID:13383 DOID:14395 DOID:1484 GARD:6233 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 SNOMEDCT_US_2020_03_01:85809002 UMLS_CUI:C0010674 CF mucoviscidosis disease_ontology DOID:1485 OMIM mapping confirmed by DO. [SN]. cystic fibrosis MESH:D003550 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys. DOID:12149 DOID:2783 ICD10CM:B67 ICD9CM:122 MESH:D004443 NCI:C84682 SNOMEDCT_US_2020_03_01:154414008 UMLS_CUI:C0013502 Echinococcosis of liver echinococcal disease hepatic echinococcosis hydatid disease hydatidosis liver echinococcus pulmonary echinococcosis disease_ontology DOID:1496 echinococcosis A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock. GARD:6043 ICD10CM:A00 ICD9CM:001 MESH:D002771 SNOMEDCT_US_2020_03_01:186087007 UMLS_CUI:C0008354 Cholera Cholera - Vibrio cholerae Cholera due to Vibrio cholerae Vibrio cholerae disease_ontology DOID:1498 cholera MESH:D002771 A disease of anatomical entity that is located_in reproductive system organs. DOID:6309 NCI:C27613 UMLS_CUI:C1335037 genital system disease disease_ontology DOID:15 reproductive system disease A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. ICD10CM:F99 MESH:D001523 NCI:C2893 SNOMEDCT_US_2020_03_01:74732009 UMLS_CUI:C0004936 disease_ontology DOID:150 disease of mental health An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons. DOID:1507 ICD10CM:B37 ICD9CM:112 MESH:D002177 NCI:C26711 SNOMEDCT_US_2020_03_01:154403005 UMLS_CUI:C0006840 Disseminated candidiasis systemic candidiasis disease_ontology DOID:1508 candidiasis A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction. ICD10CM:F60.6 ICD9CM:301.82 MESH:D010554 NCI:C92636 SNOMEDCT_US_2020_03_01:191771004 UMLS_CUI:C0004444 anxious personality disorder disease_ontology DOID:1509 avoidant personality disorder A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. ICD9CM:301.8 SNOMEDCT_US_2020_03_01:191770003 UMLS_CUI:C0029707 character disorder disease_ontology DOID:1510 personality disorder An intestinal disease located_in the cecum. MESH:D002429 SNOMEDCT_US_2020_03_01:128525008 UMLS_CUI:C0007527 disorder of cecum disease_ontology DOID:1518 cecal disease A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C3491 SNOMEDCT_US_2020_03_01:269538009 UMLS_CUI:C0149640 Caecum carcinoma Cecal cancer carcinoma of cecum disease_ontology DOID:1519 cecum carcinoma A large intestine cancer that is located_in the cecum. ICD10CM:C18.0 ICD9CM:153.4 MESH:D002430 NCI:C9329 SNOMEDCT_US_2020_03_01:93736007 UMLS_CUI:C0153437 malignant neoplasm of caecum malignant tumor of the cecum disease_ontology DOID:1521 cecum cancer A skin disease that is characterized by inflammation of subcutaneous adipose tissue. ICD10CM:M79.3 ICD9CM:729.30 MESH:D015434 NCI:C112112 SNOMEDCT_US_2020_03_01:268122002 UMLS_CUI:C0030326 disease_ontology DOID:1526 panniculitis ICD10CM:N48.8 ICD9CM:607.8 SNOMEDCT_US_2020_03_01:198558008 UMLS_CUI:C0029785 disease_ontology DOID:1529 penile disease A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. DOID:1531 MESH:D010995 NCI:C26859 SNOMEDCT_US_2020_03_01:88075009 UMLS_CUI:C0032226 disorder of pleura non-neoplastic pleural disease disease_ontology DOID:1532 pleural disease A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from two germinal layers of tissue. DOID:1905 MESH:D018198 NCI:C3729 NCI:C6930 SNOMEDCT_US_2020_03_01:8145008 UMLS_CUI:C0206625 UMLS_CUI:C1368354 malignant mixed cancer malignant mixed neoplasm mixed tumor mixed tumor, malignant disease_ontology malignant mixed tumor mixed neoplasm DOID:154 mixed cell type cancer An endocrine gland cancer located_in the parathyroid glands located in the neck. DOID:11006 DOID:1541 GARD:7329 ICD10CM:C75.0 ICD9CM:194.1 MESH:D010282 NCI:C3313 NCI:C4906 NCI:C9322 OMIM:608266 SNOMEDCT_US_2020_03_01:127020005 SNOMEDCT_US_2020_03_01:363481002 UMLS_CUI:C0030521 UMLS_CUI:C0153653 UMLS_CUI:C0687150 Parathyroid gland neoplasm carcinoma of Parathyroid gland malignant neoplasm of parathyroid gland malignant neoplasm of the Parathyroid malignant tumor of parathyroid gland neoplasm of parathyroid gland parathyroid gland cancer parathyroid neoplasm disease_ontology parathyroid gland adenocarcinoma DOID:1540 OMIM mapping confirmed by DO. [SN]. parathyroid carcinoma A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis. ICD9CM:708.8 SNOMEDCT_US_2020_03_01:267817001 UMLS_CUI:C0029839 disease_ontology DOID:1555 urticaria A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury. MESH:D007105 UMLS_CUI:C0020951 immune complex disease disease_ontology DOID:1557 hypersensitivity reaction type III disease A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues. ICD10CM:T78.3 MESH:D000799 NCI:C112175 SNOMEDCT_US_2020_03_01:41291007 UMLS_CUI:C0002994 Angioneurotic oedema Quincke's edema angioneurotic edema giant urticaria disease_ontology DOID:1558 angioedema A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. ICD10CM:F09 MESH:D019965 NCI:C34870 SNOMEDCT_US_2020_03_01:111479008 UMLS_CUI:C0029227 cognitive disease disease_ontology Organic Mental disorder DOID:1561 cognitive disorder A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection. GARD:1319 ICD10CM:B43.9 ICD9CM:117.2 MESH:D002862 SNOMEDCT_US_2020_03_01:187079000 UMLS_CUI:C0008582 Chromomycosis Mossy foot disease disease_ontology DOID:1562 chromoblastomycosis A cutaneous mycosis that results in fungal infection located in skin or of its appendages, has_material_basis_in Ascomycota fungi other than the dermatophytes. ICD9CM:111.9 MESH:D003881 SNOMEDCT_US_2020_03_01:47382004 UMLS_CUI:C0011630 disease_ontology DOID:1563 dermatomycosis A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body. ICD10CM:B49 ICD9CM:110-118.99 MESH:D009181 NCI:C3245 SNOMEDCT_US_2020_03_01:154393000 UMLS_CUI:C0026946 mycosis disease_ontology mycoses DOID:1564 fungal infectious disease ICD10CM:H02.1 ICD9CM:374.1 MESH:D004483 SNOMEDCT_US_2020_03_01:155178000 UMLS_CUI:C0013592 Ectropion of eyelid Everted margin disease_ontology DOID:1570 ectropion ICD10CM:G91.2 MESH:D006850 OMIM:236690 SNOMEDCT_US_2020_03_01:30753002 UMLS_CUI:C0020258 Low pressure hydrocephalus disease_ontology DOID:1572 OMIM mapping confirmed by DO. [SN]. normal pressure hydrocephalus ICD10CM:G91.0 ICD9CM:331.3 MESH:D006849 NCI:C34501 SNOMEDCT_US_2020_03_01:59013007 UMLS_CUI:C0009451 disease_ontology DOID:1573 communicating hydrocephalus A musculoskeletal system disease that involves inflammation or pain in the muscles, joints, or fibrous tissue. disease_ontology DOID:1575 rheumatic disease A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. DOID:3226 ICD10CM:J98 ICD9CM:519 SNOMEDCT_US_2020_03_01:155603009 UMLS_CUI:C0029582 disease_ontology DOID:1579 respiratory system disease A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia. ICD10CM:A15.5 ICD9CM:012.3 MESH:D014387 NCI:C26895 SNOMEDCT_US_2020_03_01:70341005 UMLS_CUI:C0041315 disease_ontology DOID:1583 laryngeal tuberculosis A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph. ICD9CM:517.3 MESH:D056586 NCI:C138179 SNOMEDCT_US_2020_03_01:372146004 UMLS_CUI:C0742343 acute chest syndrome in sickle cell disease disease_ontology DOID:1584 acute chest syndrome MESH:D056586 A connective tissue disease that develops from an antecedent Group A Streptococcal pharyngeal infection and has_symptom carditis, has_symptom polyarthritis, has_symptom chorea, has_symptom erythema marginatum, has_symptom subcutaneous nodules, has_symptom arthralgia, has_symptom prolonged PR interval, and/or has_symptom fever. DOID:1006 DOID:1007 GARD:5699 ICD10CM:I00 ICD10CM:I00-I02 ICD9CM:390 ICD9CM:390-392.99 MESH:D012213 NCI:C34984 SNOMEDCT_US_2020_03_01:155265007 SNOMEDCT_US_2020_03_01:274095001 UMLS_CUI:C0035436 UMLS_CUI:C0264743 ACUTE RHEUMATIC FEVER RhF - Rheumatic fever disease_ontology DOID:1586 rheumatic fever MESH:D012213 NCI:C3991 SNOMEDCT_US_2020_03_01:2897005 UMLS_CUI:C0272286 Auto-immune thrombocytopenia Immune thrombocytopenia Thrombocytopenia Due to Immune Destruction disease_ontology DOID:1587 thrombocytopenia due to platelet alloimmunization A blood platelet disease that is characterized by low a platelet count in the blood. ICD10CM:D69.6 ICD9CM:287.5 MESH:D013921 OMIM:188000 OMIM:273900 OMIM:300367 OMIM:313900 OMIM:612004 ORDO:852 SNOMEDCT_US_2020_03_01:165556002 UMLS_CUI:C0040034 disease_ontology DOID:1588 Xref MGI. thrombocytopenia A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system. DOID:6340 EFO:0003761 MESH:D003866 NCI:C34532 NCI:C35094 OMIM:608516 SNOMEDCT_US_2020_03_01:191599006 UMLS_CUI:C0011573 UMLS_CUI:C0041696 clinical depression unipolar depression disease_ontology DOID:1595 OMIM mapping confirmed by DO. [LS]. endogenous depression DOID:14672 ICD10CM:F32.9 MESH:D003863 NCI:C2982 SNOMEDCT_US_2020_03_01:41006004 UMLS_CUI:C0011570 disease_ontology DOID:1596 mental depression A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages. disease_ontology DOID:16 integumentary system disease DOID:1600 DOID:9941 ICD10CM:I88.1 ICD10CM:L04 ICD9CM:289.1 ICD9CM:683 MESH:D008199 NCI:C26821 NCI:C26966 NCI:C26978 SNOMEDCT_US_2020_03_01:154836001 SNOMEDCT_US_2020_03_01:156318008 SNOMEDCT_US_2020_03_01:19471005 UMLS_CUI:C0024205 UMLS_CUI:C0154304 UMLS_CUI:C0157705 Adenitis Inflammation of lymph node acute adenitis acute lymphadenitis chronic Lymphadenitis chronic adenitis disease_ontology DOID:1602 lymphadenitis A brain disease that is characterized by coma or unconsciousness, develops from a prolonged insufficient supply of glucose to the brain, has_symptom decreased cognition, has_symptom aberrant behavior, has_symptom seizure, and has_symptom coma. ICD10CM:E15 ICD9CM:251.0 SNOMEDCT_US_2020_03_01:267476006 UMLS_CUI:C0020617 disease_ontology DOID:1607 hypoglycemic coma A skin disease characterized_by growth of keratin on the skin or mucous membranes. MESH:D007642 NCI:C34747 SNOMEDCT_US_2020_03_01:254666005 UMLS_CUI:C0022593 disease_ontology DOID:161 keratosis A thoracic cancer that originates in the mammary gland. DOID:1648 DOID:4241 ICD10CM:C50 MESH:D001943 NCI:C9335 OMIM:114480 SNOMEDCT_US_2020_03_01:254837009 UMLS_CUI:C0006142 breast tumor malignant neoplasm of breast malignant tumor of the breast mammary cancer mammary tumor primary breast cancer disease_ontology mammary neoplasm DOID:1612 Xref MGI. OMIM mapping confirmed by DO. [SN]. breast cancer A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast. DOID:2684 DOID:2693 DOID:7226 ICD10CM:D24 MESH:D018226 NCI:C3744 NCI:C4276 NCI:C5194 SNOMEDCT_US_2020_03_01:254847007 SNOMEDCT_US_2020_03_01:269640007 SNOMEDCT_US_2020_03_01:65877006 UMLS_CUI:C0178421 UMLS_CUI:C0206650 UMLS_CUI:C0346158 UMLS_CUI:C1333137 Complex Fibroadenoma of breast Fibroadenoma Fibroadenoma of breast Juvenile fibroadenoma cellular Fibroadenoma fibroadenoma juvenile fibroadenoma of breast disease_ontology DOID:1618 breast fibroadenoma A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. ICD10CM:C80.1 ICD9CM:199 ICDO:M8000/3 MESH:D009369 NCI:C9305 SNOMEDCT_US_2020_03_01:269513004 UMLS_CUI:C0006826 malignant neoplasm malignant tumor primary cancer disease_ontology DOID:162 Updating out dated UMLS CUI. cancer A breast benign neoplasm that is has_material_basis_in epithelial tissue in which tumor cells form glands or glandlike structures. NCI:C40382 SNOMEDCT_US_2020_03_01:269640007 UMLS_CUI:C1328385 Ademoma - breast disease_ontology DOID:1625 breast adenoma MESH:D018300 NCI:C3785 SNOMEDCT_US_2020_03_01:5244003 UMLS_CUI:C0206713 ductal papilloma disease_ontology DOID:1627 intraductal papilloma A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells. DOID:6640 NCI:C5143 NCI:C6899 UMLS_CUI:C1334564 UMLS_CUI:C1510795 breast Adenomyoepithelioma with malignant Change malignant adenomyoepithelioma of breast disease_ontology adenomyoepithelioma of the breast DOID:1642 breast adenomyoepithelioma A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles. GARD:7853 ICD10CM:Q21.0 ICD9CM:745.4 MESH:D006345 NCI:C84506 OMIM:614429 OMIM:614431 OMIM:614432 ORDO:1480 SNOMEDCT_US_2020_03_01:156914003 UMLS_CUI:C0018818 Interventricular septal defect Ventricular septal abnormality disease_ontology DOID:1657 Xref MGI. ventricular septal defect A brain cancer that is located in the supratentorial region. DOID:1658 ICD10CM:C71.0 MESH:D015173 NCI:C3397 NCI:C4964 UMLS_CUI:C0038874 UMLS_CUI:C0751589 Brain neoplasm, Supratentorial malignant Supratentorial tumor disease_ontology DOID:1659 supratentorial cancer MESH:D017600 NCI:C3717 SNOMEDCT_US_2020_03_01:1513001 UMLS_CUI:C0206094 Infantile Melanotic neuroectodermal neoplasm Melanotic neuroectodermal tumor Melanotic neuroectodermal tumor of infancy Melanotic neuroectodermal tumour Melanotic neuroectodermal tumour of infancy Pigmented neuroectodermal tumour of infancy melanotic neuroectodermal tumour disease_ontology DOID:166 melanotic neuroectodermal tumor A pineal gland neoplasm located_in the brain. GARD:9369 MESH:D010871 NCI:C9344 SNOMEDCT_US_2020_03_01:31671006 UMLS_CUI:C0205898 Pineal PNET disease_ontology DOID:1664 pineoblastoma A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall. ICD10CM:J93.1 SNOMEDCT_US_2020_03_01:196103008 UMLS_CUI:C0029850 disease_ontology DOID:1673 pneumothorax MESH:D011030 A bladder disease that is characterized by inflammation of the bladder. ICD10CM:N30 ICD9CM:595 MESH:D003556 NCI:C26738 SNOMEDCT_US_2020_03_01:38822007 UMLS_CUI:C0010692 disease_ontology DOID:1679 cystitis ICD10CM:Q21.9 MESH:D006343 NCI:C84482 SNOMEDCT_US_2020_03_01:204290008 UMLS_CUI:C0018816 Cardiac septal defects Congenital septal defect of heart Septal defect septal defect disease_ontology DOID:1681 heart septal defect ICD10CM:Q24.9 ICD9CM:746.9 MESH:D006330 NCI:C34666 SNOMEDCT_US_2020_03_01:268315002 UMLS_CUI:C0018798 Congenital Heart Defects Congenital anomaly of heart Heart Malformation congenital heart defect heart defect disease_ontology Heart-congenital defect DOID:1682 OMIM mapping confirmed by DO. [SN]. congenital heart disease An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. EFO:0000516 ICD10CM:H40 ICD9CM:365 MESH:D005901 NCI:C26782 SNOMEDCT_US_2020_03_01:155120009 UMLS_CUI:C0017601 disease_ontology DOID:1686 glaucoma A glaucoma characterized by narrowing of the anterior chamber angle secondary to neovascularization along the iris and iridocorneal angle such that the aqueous fluid outflow is blocked and intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Neovascular glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Neovascular glaucoma can be related to abnormal angiogenesis with ischemic retinal diseases, inflammation, diabetes mellitus, intraocular malignancy, and autoinmmune diseases. MESH:D015355 SNOMEDCT_US_2020_03_01:193564003 UMLS_CUI:C0017609 secondary angle-closure glaucoma with rubeosis disease_ontology DOID:1687 neovascular glaucoma An endocrine gland cancer that has_material_basis_in neuroendocrine cells. ICD10CM:D3A.8 ICD9CM:209-209.99 MESH:D018358 NCI:C3809 SNOMEDCT_US_2020_03_01:55937004 UMLS_CUI:C0206754 neuroendocrine neoplasm disease_ontology DOID:169 neuroendocrine tumor A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed. MESH:D007057 ORDO:79354 ichthyoses non-syndromic ichthyosis disease_ontology DOID:1697 ichthyosis A disease of anatomical entity that occurs in the muscular and/or skeletal system. MESH:D009140 NCI:C107377 SNOMEDCT_US_2020_03_01:268047003 UMLS_CUI:C0026857 disease_ontology DOID:17 musculoskeletal system disease An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system. DOID:10009 ICD10CM:C75.9 ICD9CM:194.9 MESH:D004701 NCI:C3010 NCI:C3575 SNOMEDCT_US_2020_03_01:127015005 SNOMEDCT_US_2020_03_01:93780007 UMLS_CUI:C0014132 UMLS_CUI:C0153658 Endocrine tumor endocrine neoplasm malignant Endocrine tumor malignant neoplasm of endocrine gland malignant tumour of endocrine gland neoplasm of endocrine gland neoplasm of endocrine system disease_ontology DOID:170 endocrine gland cancer An ichthyosis that is characterized by a build-up of scales on the skin, typically on the back of the neck and trunk resulting from skin cells that do not properly separate from the outermost surface of the skin, and has_material_basis_in X-linked recessive mutation or deletion of the STS gene on chromosome Xp22. GARD:7904 ICD10CM:Q80.1 MESH:D016114 NCI:C84779 OMIM:308100 SNOMEDCT_US_2020_03_01:72523005 UMLS_CUI:C0079588 X-linked ichthyosis with steryl-sulphatase deficiency X-linked placental steryl-sulphatase deficiency X-linked recessive ichthyosis disease_ontology DOID:1700 OMIM mapping confirmed by DO. [LS]. X-linked ichthyosis A lipid metabolism disorder that involves defects in steroid metabolism. MESH:D043202 UMLS_CUI:C1257809 disease_ontology DOID:1701 steroid inherited metabolic disorder An ichthyosis that has_material_basis_in heterozygous mutation in the filaggrin gene on chromosome 1q21 and is characterized by dead skin cells accumulate in thick, dry scales on your skin's surface. GARD:6752 ICD10CM:Q80.0 MESH:D016112 NCI:C84778 OMIM:146700 SNOMEDCT_US_2020_03_01:205551004 UMLS_CUI:C0079584 Dominant congenital ichthyosiform erythroderma disease_ontology DOID:1702 OMIM mapping confirmed by DO. [SN]. ichthyosis vulgaris MESH:D017599 SNOMEDCT_US_2020_03_01:73676002 UMLS_CUI:C0206093 primitive Neuroectodermal neoplasm disease_ontology DOID:171 neuroectodermal tumor An aortic valve disease that is characterized by narrowing of the heart's aortic valve opening. DOID:12034 DOID:1711 GARD:5830 ICD10CM:I06.0 ICD10CM:Q23.0 ICD10CM:Q25.1 ICD9CM:395.0 ICD9CM:746.3 MESH:D001024 NCI:C50462 SNOMEDCT_US_2020_03_01:155282009 SNOMEDCT_US_2020_03_01:18546004 SNOMEDCT_US_2020_03_01:60573004 UMLS_CUI:C0003507 UMLS_CUI:C0152417 UMLS_CUI:C0155567 Aortic stenosis Rheumatic aortic stenosis rheumatic aortic valve stenosis disease_ontology DOID:1712 Xref MGI. OMIM mapping confirmed by DO. [SN]. aortic valve stenosis MESH:D001024 MESH:D049309 NCI:C97041 SNOMEDCT_US_2020_03_01:65540008 UMLS_CUI:C0333992 Clear cell acanthoma Pale (Clear cell) acanthoma disease_ontology DOID:172 clear cell acanthoma DOID:10297 DOID:11480 DOID:12880 DOID:13836 DOID:1723 DOID:9780 DOID:9781 DOID:9782 DOID:9783 ICD10CM:K26 ICD9CM:532 MESH:D004381 NCI:C26755 SNOMEDCT_US_2020_03_01:155691003 SNOMEDCT_US_2020_03_01:39755000 UMLS_CUI:C0010474 UMLS_CUI:C0013295 Curling Ulcer Curling's ulcers Stress Ulcer disease_ontology DOID:1724 Adding UMLS CUI for Curling Ulcer C0013295. duodenal ulcer An organ system cancer that is located in the peritoneum. ICD10CM:C48.1 ICD9CM:158.8 SNOMEDCT_US_2020_03_01:187808008 UMLS_CUI:C0153466 disease_ontology cancer of peritoneum peritoneal neoplasm DOID:1725 peritoneum cancer MESH:D012170 NCI:C34981 SNOMEDCT_US_2020_03_01:46085004 UMLS_CUI:C0035328 Occlusion, of retinal vein Retinal vein occlusion disease_ontology DOID:1727 retinal vein occlusion ICD10CM:H34 ICD9CM:362.3 NCI:C34980 SNOMEDCT_US_2020_03_01:267717005 UMLS_CUI:C0035326 Retinal vasc. occlusion disease_ontology DOID:1729 retinal vascular occlusion NCI:C6796 UMLS_CUI:C1333371 Eccrine tumor eccrine skin neoplasm disease_ontology DOID:173 eccrine sweat gland neoplasm A primary systemic mycosis that results in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains. DOID:351 ICD10CM:B39 ICD9CM:115 MESH:C538362 MESH:D006660 NCI:C34977 NCI:C77201 SNOMEDCT_US_2020_03_01:266218008 UMLS_CUI:C0019655 UMLS_CUI:C0035288 disease_ontology DOID:1731 histoplasmosis A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection. DOID:1732 GARD:6219 ICD10CM:A07.2 ICD9CM:007.4 MESH:D003457 NCI:C128408 SNOMEDCT_US_2020_03_01:186126003 UMLS_CUI:C0010418 Cryptosporidial gastroenteritis Infection by Cryptosporidium intestinal cryptosporidiosis disease_ontology DOID:1733 cryptosporidiosis GARD:8604 MESH:D049309 NCI:C7419 UMLS_CUI:C0846967 disease_ontology DOID:174 acanthoma MESH:D049309 ICD9CM:292.1 MESH:D011605 SNOMEDCT_US_2020_03_01:191498001 UMLS_CUI:C0033937 Drug-induced psychosis Drug-induced psychotic disorder disease_ontology DOID:1742 drug psychosis A carcinoma that derives_from squamous epithelial cells. DOID:5512 EFO:0000707 GARD:1091 MESH:D002294 MESH:D018307 NCI:C2929 SNOMEDCT_US_2020_03_01:154605007 UMLS_CUI:C0007137 UMLS_CUI:C0751688 epidermoid carcinoma malignant squamous cell tumor squamous carcinoma squamous cell Epithelioma squamous cell cancer disease_ontology DOID:1749 squamous cell carcinoma A cardiovascular cancer that is located_in blood vessels. DOID:3339 DOID:5454 DOID:5548 DOID:7019 DOID:7020 DOID:7392 MESH:D019043 NCI:C5348 NCI:C5380 NCI:C5383 NCI:C5388 NCI:C7390 SNOMEDCT_US_2020_03_01:126737003 SNOMEDCT_US_2020_03_01:93817006 UMLS_CUI:C0282607 UMLS_CUI:C0346845 UMLS_CUI:C1290407 UMLS_CUI:C1334616 UMLS_CUI:C1334617 UMLS_CUI:C1334630 UMLS_CUI:C1335753 Blood Vessel neoplasm Blood vessel tumor Blood vessel tumors Blood vessel tumour disorder Haemangiomatous tumour blood vessel neoplasm leiomyosarcoma of the renal Vein malignant great vessel tumor malignant tumor of pulmonary Vein malignant tumor of pulmonary artery malignant vascular neoplasm malignant vascular tumor neoplasm of great vessel pulmonary artery malignant neoplasm pulmonary vein malignant neoplasm renal vein leiomyosarcoma vascular tissue neoplasm vascular tumors disease_ontology DOID:175 vascular cancer A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart. MESH:D008946 NCI:C50654 SNOMEDCT_US_2020_03_01:79619009 UMLS_CUI:C0026269 Mitral stenosis disease_ontology DOID:1754 mitral valve stenosis ICD10CM:G51 ICD9CM:351 MESH:D005155 NCI:C27594 SNOMEDCT_US_2020_03_01:90039006 UMLS_CUI:C0015464 disease_ontology DOID:1756 facial nerve disease MESH:D005150 NCI:C84703 OMIM:141300 SNOMEDCT_US_2020_03_01:29868009 UMLS_CUI:C0015458 PARRY-ROMBERG SYNDROME disease_ontology DOID:1757 OMIM mapping confirmed by DO. [SN]. facial hemiatrophy An organ system cancer that located_in the heart and blood vessels. NCI:C4784 SNOMEDCT_US_2020_03_01:721573003 UMLS_CUI:C0497243 Cardiovascular tumors cardiovascular neoplasm disease_ontology DOID:176 cardiovascular cancer GARD:7010 ICD10CM:G51.2 MESH:D008556 NCI:C84886 OMIM:155900 SNOMEDCT_US_2020_03_01:2511001 UMLS_CUI:C0025235 Cheilitis granulomatosa of Mescher-Melkersson-Rosenthal Melkersson's syndrome disease_ontology DOID:1761 OMIM mapping confirmed by DO. [SN]. Melkersson-Rosenthal syndrome ICD10CM:K59.31 MESH:D008532 SNOMEDCT_US_2020_03_01:28536002 UMLS_CUI:C0025162 disease_ontology DOID:1770 toxic megacolon A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. DOID:0000405 DOID:2403 DOID:2869 DOID:324 DOID:325 DOID:45 ICD10CM:I72.9 ICD9CM:442.9 MESH:D000783 MESH:D014652 MESH:D020758 MESH:D020760 NCI:C26693 NCI:C35117 SNOMEDCT_US_2020_03_01:27550009 SNOMEDCT_US_2020_03_01:371029002 SNOMEDCT_US_2020_03_01:432119003 UMLS_CUI:C0002940 UMLS_CUI:C0042373 UMLS_CUI:C0752127 UMLS_CUI:C0752130 vascular tissue disease disease_ontology DOID:178 vascular disease An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage. DOID:10008 ICD10CM:C73 ICD9CM:193 KEGG:05216 MESH:D013964 NCI:C3414 NCI:C7510 SNOMEDCT_US_2020_03_01:127018007 SNOMEDCT_US_2020_03_01:94098005 UMLS_CUI:C0007115 UMLS_CUI:C0040136 Thyroid gland neoplasm malignant neoplasm of thyroid gland malignant tumour of thyroid gland neoplasm of thyroid gland thyroid neoplasm disease_ontology DOID:1781 thyroid gland cancer An endocrine gland cancer located_in the pituitary gland located at the base of the brain. DOID:5671 GARD:9371 ICD10CM:C75.1 MESH:D010911 NCI:C3330 NCI:C4769 SNOMEDCT_US_2020_03_01:127024001 SNOMEDCT_US_2020_03_01:93964007 UMLS_CUI:C0032019 UMLS_CUI:C0496842 Pituitary gland neoplasm malignant Pituitary neoplasm malignant tumor of pituitary gland neoplasm of pituitary gland pituitary gland cancer pituitary neoplasm disease_ontology DOID:1785 pituitary cancer MESH:D000314 NCI:C2860 SNOMEDCT_US_2020_03_01:54292009 UMLS_CUI:C0001630 Adrenal Rest neoplasm disease_ontology DOID:1786 adrenal rest tumor MESH:D000314 A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. MESH:D010493 NCI:C34915 SNOMEDCT_US_2020_03_01:3238004 UMLS_CUI:C0031046 disease_ontology DOID:1787 pericarditis A peritoneum cancer that develops from cells of the mesothelium and is located_in the peritoneum. DOID:0050874 DOID:7954 ICD10CM:C45.1 NCI:C8704 NCI:C9350 SNOMEDCT_US_2020_03_01:187806007 UMLS_CUI:C0346109 UMLS_CUI:C0854886 Advanced malignant Mesothelioma of Peritoneum advanced malignant peritoneal mesothelioma malignant mesothelioma of peritoneum disease_ontology DOID:1788 peritoneal mesothelioma A cell type cancer that has_material_basis_in mesothelial tissue that develops from the thin layer of tissue that covers many of the internal organs. DOID:4487 DOID:6965 DOID:7434 MESH:C562839 NCI:C27926 NCI:C4456 NCI:C7865 NCI:C8420 OMIM:156240 SNOMEDCT_US_2020_03_01:109378008 UMLS_CUI:C0278752 UMLS_CUI:C0345967 UMLS_CUI:C0392400 UMLS_CUI:C1332338 Diffuse malignant Mesothelioma advanced malignant mesothelioma asbestos-related malignant mesothelioma malignant tumor of Mesothelium disease_ontology DOID:1790 OMIM mapping confirmed by DO. [SN]. malignant mesothelioma A carcinoma that is located_in the inside of the abdomen. NCI:C40022 UMLS_CUI:C1514428 primary peritoneal carcinoma disease_ontology DOID:1791 peritoneal carcinoma An endocrine gland cancer located_in the pancreas. DOID:14356 DOID:1797 DOID:3588 DOID:9859 GARD:9364 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 SNOMEDCT_US_2020_03_01:126859007 SNOMEDCT_US_2020_03_01:187796007 SNOMEDCT_US_2020_03_01:93715005 SNOMEDCT_US_2020_03_01:93823001 SNOMEDCT_US_2020_03_01:94082003 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463 Ca body of pancreas Ca head of pancreas Ca tail of pancreas malignant neoplasm of body of pancreas malignant neoplasm of head of pancreas malignant neoplasm of tail of pancreas pancreas neoplasm pancreatic neoplasm pancreatic tumor disease_ontology DOID:1793 Xref MGI. pancreatic cancer A pancreatic cancer that arises from the epithelial cells of the exocrine pancreatic tissue. DOID:1794 NCI:C7430 SNOMEDCT_US_2020_03_01:255088001 UMLS_CUI:C0346648 malignant neoplasm of the Exocrine pancreas malignant tumor of exocrine pancreas malignant tumour of exocrine pancreas disease_ontology DOID:1795 malignant exocrine pancreas neoplasm An islet cell tumor that has_material_basis_in epithelial cells. GARD:13034 ICD10CM:C25.4 ICD9CM:157.4 MESH:D018273 NCI:C3770 SNOMEDCT_US_2020_03_01:254612002 UMLS_CUI:C1328479 Islet cell carcinoma carcinoma of endocrine pancreas malignant neoplasm of islets of Langerhans pancreatic neuroendocrine carcinoma disease_ontology DOID:1798 pancreatic endocrine carcinoma A pancreatic cancer that is located_in the pancreatic islet cells. DOID:10165 ICD10CM:C25.4 ICD10CM:D13.7 MESH:D007516 NCI:C27031 SNOMEDCT_US_2020_03_01:254611009 SNOMEDCT_US_2020_03_01:261713004 UMLS_CUI:C0242363 UMLS_CUI:C0496784 Islet cell neoplasm Islet cell tumor Islet cell tumour endocrine pancreas cancer islet cell tumour malignant pancreatic Endocrine tumor malignant pancreatic Endocrine tumour malignant tumor of endocrine pancreas malignant tumour of endocrine pancreas pancreatic Endocrine neoplasm disease_ontology DOID:1799 islet cell tumor A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra. DOID:579 NCI:C27599 UMLS_CUI:C1335051 Non-neoplastic urinary tract disease urinary tract disease disease_ontology DOID:18 urinary system disease A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma. MESH:D018214 NCI:C8422 SNOMEDCT_US_2020_03_01:189896007 UMLS_CUI:C0206640 Fibro-osteoma disease_ontology peripheral ossifying fibroma DOID:180 ossifying fibroma A carcinoma that derives_from neuroendocrine cells. MESH:D018278 NCI:C3773 SNOMEDCT_US_2020_03_01:55937004 UMLS_CUI:C0206695 disease_ontology DOID:1800 neuroendocrine carcinoma ICD9CM:355.9 MESH:D020422 SNOMEDCT_US_2020_03_01:32595002 UMLS_CUI:C0235880 disease_ontology DOID:1802 mononeuritis MESH:D009443 NCI:C116381 SNOMEDCT_US_2020_03_01:247378004 UMLS_CUI:C0027813 peripheral neuritis disease_ontology DOID:1803 neuritis ICD10CM:G90.5 ICD9CM:337.2 MESH:D012019 NCI:C85042 OMIM:604335 SNOMEDCT_US_2020_03_01:203492008 UMLS_CUI:C0034931 disease_ontology DOID:1811 OMIM mapping confirmed by DO. [SN]. reflex sympathetic dystrophy A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue. MESH:D002114 NCI:C3672 SNOMEDCT_US_2020_03_01:237881004 UMLS_CUI:C0006663 Pathologically calcified structure pathologic calcification disease_ontology DOID:182 calcinosis A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years. MESH:D004832 NCI:C3023 SNOMEDCT_US_2020_03_01:163596002 UMLS_CUI:C0014553 petit mal seizure pyknolepsy disease_ontology absence seizure DOID:1825 childhood absence epilepsy A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. EFO:0000474 ICD10CM:G40.909 ICD9CM:345.9 MESH:D004827 NCI:C3020 SNOMEDCT_US_2020_03_01:267698007 UMLS_CUI:C0014544 epilepsy syndrome epileptic syndrome disease_ontology DOID:1826 epilepsy An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain. MESH:D004829 NCI:C3021 OMIM:600669 SNOMEDCT_US_2020_03_01:155043003 UMLS_CUI:C0014548 Generalised epilepsy disease_ontology DOID:1827 Xref MGI. idiopathic generalized epilepsy ICD9CM:598.8 UMLS_CUI:C0029752 disease_ontology DOID:1829 urethral stricture MESH:D14525 GARD:1521 MESH:D007706 NCI:C75486 OMIM:309400 SNOMEDCT_US_2020_03_01:59178007 UMLS_CUI:C0022716 COPPER TRANSPORT DISEASE Menkes kinky-hair syndrome steely hair syndrome disease_ontology DOID:1838 OMIM mapping confirmed by DO. [SN]. Menkes disease A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue. DOID:3348 MESH:D001859 NCI:C9343 SNOMEDCT_US_2020_03_01:126537000 UMLS_CUI:C0005967 CA - bone cancer bone neoplasm bone tumour malignant bone neoplasm malignant bone tumour malignant neoplasm of bone malignant osseous tumor neoplasm of bone osseous tumor disease_ontology DOID:184 bone cancer A drug dependence that involves the continued use of cannabis despite problems related to use of the substance. ICD10CM:F12.2 ICD9CM:304.3 MESH:D002189 NCI:C34445 SNOMEDCT_US_2020_03_01:268766005 UMLS_CUI:C0006870 disease_ontology DOID:1849 cannabis dependence A cholestasis characterized by impairment of the bile flow caused by obstruction located_in liver. GARD:10214 MESH:D002780 NCI:C84400 ORDO:284385 SNOMEDCT_US_2020_03_01:4637005 UMLS_CUI:C0008372 neonatal intrahepatic cholestasis disease_ontology DOID:1852 Xref MGI. intrahepatic cholestasis A bone disease characterized by replacement of bone in the jaws with fibrous tissue leding to facial swelling that has_material_basis_in heterozygous mutation in SH3BP2 on chromosome 4p16.3. GARD:6036 ICD10CM:M27.8 MESH:D002636 NCI:C84630 OMIM:118400 SNOMEDCT_US_2020_03_01:76098004 UMLS_CUI:C0008029 disease_ontology DOID:1856 OMIM mapping confirmed by DO. [SN]. cherubism A syndrome that is characterized by polyostotic fibrous dysplasia, precocious puberty, and café-au-lait spots and has_material_basis_in spontaneous post zygotic missense mutation at ARG201 or Gln227 of the GNAS gene during embryogenesis. DOID:11345 GARD:6995 ICD10CM:Q78.1 ICD9CM:756.54 NCI:C34610 OMIM:174800 SNOMEDCT_US_2020_03_01:726029005 UMLS_CUI:C0016065 fibrous dysplasia of bone osteitis fibrosa disseminata polyostotic fibrous dysplasia disease_ontology DOID:1858 OMIM mapping confirmed by DO. [SN]. McCune Albright syndrome MESH:D005359 A bone cancer and jaw disease that is located in the jaw and results in a swollen jaw, results in numbness or a tingling sensation in jaw, and results in an abnormal growth of the jaw bone. MESH:D007573 SNOMEDCT_US_2020_03_01:126634001 UMLS_CUI:C0022364 neoplasm of jaw disease_ontology jaw neoplasm DOID:1862 jaw cancer MESH:D012888 NCI:C3375 SNOMEDCT_US_2020_03_01:126538005 UMLS_CUI:C0037305 disease_ontology DOID:1863 skull cancer ICD10CM:M27.1 ICD9CM:526.3 MESH:D006101 SNOMEDCT_US_2020_03_01:15350006 UMLS_CUI:C0162375 central giant cell (reparative) granuloma central giant cell granuloma central giant cell reparative granuloma of jaw disease_ontology DOID:1866 giant cell reparative granuloma EFO:0004234 Sexual impotence erectile dysfunction disease_ontology DOID:1875 impotence ICD10CM:F52.9 NCI:C3347 SNOMEDCT_US_2020_03_01:39894007 UMLS_CUI:C0549622 disease_ontology DOID:1876 sexual dysfunction A heart septal defect located_in in the septum that separates the two atria of the heart. ICD10CM:Q21.1 MESH:D006344 NCI:C84473 OMIM:PS108800 ORDO:1478 SNOMEDCT_US_2020_03_01:156915002 UMLS_CUI:C0018817 atrial septal defect atrioseptal defect auricular septal defect congenital atrial septal defect interatrial septal defect interauricular septal defect disease_ontology DOID:1882 Xref MGI. atrial heart septal defect A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 NCI:C3098 SNOMEDCT_US_2020_03_01:154349000 UMLS_CUI:C0019196 NANBH Viral hepatitis C chronic hepatitis C hepatitis C infection hepatitis nonA nonB disease_ontology DOID:1883 hepatitis C A hepatitis that involves viral infection causing inflammation of the liver. DOID:12548 DOID:1331 DOID:1885 MESH:D006524 UMLS_CUI:C0019194 Viral hepatitis with hepatic coma animal viral hepatitis human viral hepatitis disease_ontology DOID:1884 viral hepatitis A cranial nerve disease that is located_in the optic nerve. MESH:D009901 NCI:C79698 SNOMEDCT_US_2020_03_01:77157004 UMLS_CUI:C0029132 disorder of the second nerve optic nerve disorder optic neuropathy disease_ontology DOID:1891 optic nerve disease MESH:D051677 NCI:C4247 SNOMEDCT_US_2020_03_01:34360000 UMLS_CUI:C0334463 Fibroxanthosarcoma MFH disease_ontology DOID:1907 malignant fibrous histiocytoma A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. EFO:0000756 KEGG:05218 MESH:D008545 NCI:C3224 SNOMEDCT_US_2020_03_01:2092003 UMLS_CUI:C0025202 Naevocarcinoma malignant melanoma disease_ontology DOID:1909 melanoma MESH:D008545 A germ cell cancer that has_material_basis_in cells that line the yolk sac of the embryo. MESH:D018240 NCI:C3011 SNOMEDCT_US_2020_03_01:74409009 UMLS_CUI:C0014145 Hepatoid yolk sac tumour Yolk Sac neoplasm Yolk sac tumor Yolk sac tumour endodermal sinus tumour infantile embryonal carcinoma disease_ontology DOID:1911 endodermal sinus tumor ICD10CM:E79.1 MESH:D007926 NCI:C61255 OMIM:300322 SNOMEDCT_US_2020_03_01:190918000 UMLS_CUI:C0023374 Complete hypoxanthine-guanine phosphoribosyltransferase deficiency HG-PRT deficiency Hypoxanthine-guanine phosphoribosyltransferase deficiency Hypoxanthine-guanine-phosphoribosyltransferase deficiency Lesch - Nyhan syndrome X-linked hyperuricemia deficiency of IMP pyrophosphorylase hypoxanthine guanine phosphoribosyltransferase deficiency disease_ontology DOID:1919 OMIM mapping confirmed by DO. [SN]. Lesch-Nyhan syndrome A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary or testis and derives_from granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. DOID:12293 MESH:D018312 NCI:C3794 SNOMEDCT_US_2020_03_01:253028001 UMLS_CUI:C0206724 Sex Cord-Stromal neoplasm Sex cord stromal tumour Specialized gonadal neoplasm Specialized gonadal tumor Specialized gonadal tumour sex cord-gonadal stromal tumour disease_ontology DOID:192 sex cord-gonadal stromal tumor An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood. MESH:D033461 NCI:C3961 SNOMEDCT_US_2020_03_01:271198001 UMLS_CUI:C0740394 Blood urate raized uricacidemia disease_ontology DOID:1920 hyperuricemia A chromosomal duplication syndrome that is characterized by infertility and that has_material_basis_in an extra X chromosome in cells in men. GARD:8705 ICD10CM:Q98.0 ICD9CM:758.7 MESH:D007713 NCI:C34752 SNOMEDCT_US_2020_03_01:405770005 UMLS_CUI:C0022735 47, XXY Hypogonadotropic Hypogonadism Klinefelter's syndrome XXY syndrome XXY trisomy disease_ontology DOID:1921 No OMIM mapping, confirmed by DO. [LS]. Klinefelter syndrome A gonadal disease that is characterized by atypical development of chromosomal, gonadal, or anatomic sex. MESH:D012734 UMLS_CUI:C0036875 sex development disorder sex differentiation disease disease_ontology DOID:1923 disorder of sexual development A gonadal disease that is characterized by diminished functional activity of the gonads. MESH:D007006 NCI:C9227 OMIM:241100 OMIM:312300 SNOMEDCT_US_2020_03_01:48130008 UMLS_CUI:C0020619 disease_ontology DOID:1924 hypogonadism An autosomal dominant non-syndromic intellectual disability that is characterized by mental retardation associated with coarse facial features, hypertrichosis, sparse scalp hair, and hypoplastic or absent fifth fingernails or toenails. GARD:6124 MESH:C536436 NCI:C35321 OMIM:PS135900 ORDO:1465 SNOMEDCT_US_2020_03_01:10007009 UMLS_CUI:C0265338 Dwarfism-Onychodysplasia Fifth Digit Syndrome Short Stature-Onychodysplasia. disease_ontology DOID:1925 OMIM mapping confirmed by DO. [SN]. Coffin-Siris syndrome A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver. GARD:8233 ICD10CM:E75.22 MESH:D005776 NCI:C61268 ORDO:355 SNOMEDCT_US_2020_03_01:190794006 UMLS_CUI:C0017205 Gaucher disease acid beta-glucosidase deficiency glocucerebrosidase deficiency glucosylceramide beta-glucosidase deficiency kerasin thesaurismosis disease_ontology DOID:1926 Xref MGI. OMIM mapping confirmed by DO. [SN]. Gaucher's disease A lipid storage disease characterized by functional deficiencies in the enzymes needed for lysosomal degradation of sphingolipid substrates. GARD:7672 ICD10CM:E75.3 MESH:D013106 NCI:C117254 SNOMEDCT_US_2020_03_01:58459009 UMLS_CUI:C0037899 Sphingolipidosis sphingolipidoses disease_ontology DOID:1927 sphingolipidosis A syndrome that is characterized by mild to moderate intellectual disability, a broad forehead, a short nose with a broad tip, full cheeks, and a wide mouth with full lips and difficulty with visual-spatial tasks and has_material_basis_in hemizygous deletion of 1.5 to 1.8 Mb on chromosome 7q11.23. ICD10CM:Q93.82 MESH:D018980 NCI:C85232 OMIM:194050 SNOMEDCT_US_2020_03_01:63247009 UMLS_CUI:C0175702 Fanconi Schlesinger syndrome disease_ontology DOID:1928 OMIM mapping confirmed by DO. [LS]. Williams-Beuren syndrome An aortic valve stenosis that is characterized by a narrowing of the section of the aorta just above the valve that connects the aorta to the heart. GARD:743 ICD10CM:Q25.3 MESH:D021921 NCI:C85176 OMIM:185500 SNOMEDCT_US_2020_03_01:204436002 UMLS_CUI:C0003499 Supra-valvular aortic stenosis disease_ontology DOID:1929 supravalvular aortic stenosis An organ system cancer that is manifested in the reproductive organs. DOID:1900 NCI:C3674 UMLS_CUI:C0178830 Reproductive tumor malignant reproductive system neoplasm disease_ontology cancer of reproductive system DOID:193 reproductive organ cancer A syndrome characterized by pituitary dysfunction, childhood onset ataxia, peripheral neuropathy, spastic paraplegia, and chorioretinopathy that has_material_basis_in homozygous or compound heterozygous mutation in PNPLA6 on chromosome 19p13.2. GARD:12635 MEDDRA:10056710 MESH:D007849 NCI:C34760 OMIM:245800 ORDO:2377 SNOMEDCT_US_2020_03_01:232059000 UMLS_CUI:C0023138 LNMS disease_ontology Laurence-Moon-Biedl syndrome DOID:1930 OMIM mapping confirmed by DO. [SN]. Laurence-Moon syndrome A syndrome that is characterized by delayed development, intellectual disability, severe speech impairment, and problems with movement and balance. GARD:5810 ICD10CM:Q93.51 MESH:D017204 NCI:C75462 OMIM:105830 SNOMEDCT_US_2020_03_01:76880004 UMLS_CUI:C0162635 happy puppet syndrome puppetlike syndrome disease_ontology DOID:1932 OMIM mapping confirmed by DO. [SN]. Angelman syndrome MESH:D017204 A syndrome characterized by short stature, moderate to sever intellectual disability, distinctive facial features and broad thumbs and first toes. GARD:7593 ICD10CM:Q87.2 MESH:D012415 NCI:C75466 OMIM:180849 OMIM:610543 OMIM:613684 ORDO:783 SNOMEDCT_US_2020_03_01:157032007 UMLS_CUI:C0035934 Broad Thumb-Hallux syndrome Rubinstein syndrome proximal chromosome 16p13.3 deletion syndrome disease_ontology DOID:1933 Xref MGI. OMIM mapping confirmed by DO. [SN]. Rubinstein-Taybi syndrome A bone development disease that results in defective ossification of located in bone. MESH:D004413 NCI:C34560 SNOMEDCT_US_2020_03_01:109420003 UMLS_CUI:C0013393 disease_ontology DOID:1934 dysostosis A syndrome that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, hypogonadism, and renal failure in some cases. GARD:6866 ICD10CM:Q87.89 MESH:D020788 NCI:C118632 OMIM:PS209900 ORDO:110 SNOMEDCT_US_2020_03_01:5619004 UMLS_CUI:C0752166 disease_ontology DOID:1935 OMIM mapping confirmed by DO. [SN]. Bardet-Biedl syndrome EFO:0003914 ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C35768 SNOMEDCT_US_2020_03_01:155414001 UMLS_CUI:C0004153 disease_ontology DOID:1936 atherosclerosis MESH:D050197 A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively. DOID:10996 ICD10CM:A59 ICD9CM:131 MESH:D014245 NCI:C35720 SNOMEDCT_US_2020_03_01:56335008 UMLS_CUI:C0040921 disease_ontology trichomonas infection DOID:1947 trichomoniasis A cholangitis that is characterized by an inflammation that is located in the gallbladder. DOID:1948 DOID:2829 DOID:9438 GARD:30 ICD10CM:K81 ICD9CM:575.10 MESH:D002764 NCI:C34465 OMIM:600803 SNOMEDCT_US_2020_03_01:76581006 UMLS_CUI:C0008325 acute and chronic cholecystitis acute cholecystitis acute on chronic cholecystitis chronic cholecystitis disease_ontology DOID:1949 OMIM mapping confirmed by DO. [SN]. cholecystitis A female reproductive system disease that is located_in the fallopian tube. MESH:D005184 NCI:C26771 SNOMEDCT_US_2020_03_01:128134005 UMLS_CUI:C0015556 disease_ontology DOID:1962 fallopian tube disease A fallopian tube cancer that is located_in the fallopian tube. MESH:D005185 NCI:C3867 SNOMEDCT_US_2020_03_01:276870001 UMLS_CUI:C0238122 cancer of the fallopian tube carcinoma of fallopian tube fallopian tube Ca disease_ontology DOID:1963 fallopian tube carcinoma A female reproductive organ cancer that is located_in fallopian tube. DOID:1961 GARD:9162 ICD10CM:C57.0 ICD9CM:183.2 MESH:D005185 NCI:C3032 NCI:C7480 SNOMEDCT_US_2020_03_01:126916003 SNOMEDCT_US_2020_03_01:93794008 UMLS_CUI:C0015558 UMLS_CUI:C0153579 fallopian tube neoplasm malignant neoplasm of uterine tube malignant tumor of fallopian tube malignant tumour of fallopian tube neoplasm of fallopian tube tumor of the fallopian tube tumor, fallopian tube, malignant disease_ontology DOID:1964 fallopian tube cancer A smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis. GARD:6880 MESH:D007890 NCI:C3158 SNOMEDCT_US_2020_03_01:443719001 UMLS_CUI:C0023269 Leiomyosarcomas disease_ontology DOID:1967 leiomyosarcoma A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance. DOID:1968 ICD10CM:G80 MESH:D002547 NCI:C34460 SNOMEDCT_US_2020_03_01:155024003 UMLS_CUI:C0007789 infantile cerebral palsy disease_ontology DOID:1969 cerebral palsy A carcinosarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium. MESH:D018195 NCI:C9474 SNOMEDCT_US_2020_03_01:189804002 UMLS_CUI:C0001442 Adenosarcoma mullerian Adenosarcoma disease_ontology DOID:1974 adenosarcoma MESH:D018195 MESH:D012004 NCI:C3350 SNOMEDCT_US_2020_03_01:126847008 UMLS_CUI:C0034885 Rectal tumor neoplasm of rectum rectum neoplasm disease_ontology DOID:1984 rectal benign neoplasm A colorectal cancer that is located_in the rectum. DOID:1989 ICD10CM:C20 ICD9CM:154.1 MESH:D012004 NCI:C7418 NCI:C9382 SNOMEDCT_US_2020_03_01:254582000 SNOMEDCT_US_2020_03_01:93984006 UMLS_CUI:C0007113 UMLS_CUI:C0949022 carcinoma of rectum carcinoma of the rectum malignant Rectal tumor malignant neoplasm of rectum malignant rectum tumor malignant tumor of rectum rectal cancer disease_ontology cancer of rectum DOID:1993 rectum cancer A rectum cancer that derives_from epithelial cells of glandular origin. NCI:C9383 SNOMEDCT_US_2020_03_01:254582000 UMLS_CUI:C0149978 Rectal adenocarcinoma disease_ontology DOID:1996 rectum adenocarcinoma MESH:D005870 NCI:C3055 SNOMEDCT_US_2020_03_01:443790001 UMLS_CUI:C0017525 disease_ontology DOID:200 benign giant cell tumor A nervous system benign neoplasm that is characterized as a nerve tissue tumor. MESH:D009463 NCI:C3275 SNOMEDCT_US_2020_03_01:25169009 UMLS_CUI:C0027858 disease_ontology DOID:2001 neuroma ICD9CM:362.56 MESH:D019773 SNOMEDCT_US_2020_03_01:193391002 UMLS_CUI:C0339543 Macular puckering of retina Macular retinal puckering cellophane maculopathy disease_ontology DOID:2006 preretinal fibrosis ICD10CM:H35.3 ICD9CM:362.5 SNOMEDCT_US_2020_03_01:193384000 UMLS_CUI:C0339436 degeneration of macula and posterior pole of retina degeneration of macula or posterior pole disease_ontology DOID:2007 degeneration of macula and posterior pole A musculoskeletal system cancer that is located_in connective tissue. MESH:D009372 SNOMEDCT_US_2020_03_01:126598008 UMLS_CUI:C0027656 Tumour of connective tissue connective tissue neoplasm neoplasm of connective tissues disease_ontology DOID:201 connective tissue cancer A T cell deficiency that results from the disfunction or underdevelopment of the thymus. ICD10CM:D81.4 ICD9CM:279.13 OMIM:242700 ORDO:83471 SNOMEDCT_US_2020_03_01:55602000 UMLS_CUI:C0152094 Nezelof's syndrome T-cell immunodeficiency with thymic aplasia TIDTA thymic aplasia thymic dysplasia with normal immunoglobulins disease_ontology DOID:2012 OMIM mapping confirmed by DO. [SN]. Nezelof syndrome ICD10CM:E16.1 MESH:D006946 SNOMEDCT_US_2020_03_01:154694003 UMLS_CUI:C0020459 hyperinsulinemia disease_ontology DOID:2018 hyperinsulinism A female reproductive organ cancer that is located_in the placenta. DOID:2023 ICD10CM:C58 ICD9CM:181 NCI:C3555 SNOMEDCT_US_2020_03_01:188187004 UMLS_CUI:C0153572 Placental tumors malignant Placental tumor malignant neoplasm of placenta neoplasm of placenta placental cancer primary malignant neoplasm of placenta disease_ontology DOID:2021 placenta cancer A choriocarcicoma that develops in the presence of a preceding gestational event. NCI:C4646 SNOMEDCT_US_2020_03_01:1884006 UMLS_CUI:C0349557 Gestational choriocarcinoma Gestational chorionepithelioma Molar pregnancy with choriocarcinoma disease_ontology DOID:2025 gestational choriocarcinoma A hyperostosis that involves formation of new bone on the surface of preexisting bone. ICD10CM:M27.8 ICD9CM:726.91 MESH:D005096 NCI:C3029 SNOMEDCT_US_2020_03_01:80400009 UMLS_CUI:C1442903 bone spur bony outgrowth orbital exostosis osteophyte swimmer's exostosis disease_ontology DOID:203 exostosis A cognitive disorder that involves an excessive, irrational dread of everyday situations. DOID:12884 ICD10CM:F41.9 MESH:D001008 NCI:C2878 OMIM:607834 SNOMEDCT_US_2020_03_01:65673007 UMLS_CUI:C0003469 anxiety anxiety state disease_ontology DOID:2030 anxiety disorder A specific developmental disorder that involves specific developmental disorders of speech and language. ICD10CM:F80.9 MESH:D003147 NCI:C2958 SNOMEDCT_US_2020_03_01:74825008 UMLS_CUI:C0009460 disease_ontology DOID:2033 communication disorder A brain disease that is characterized by cerebral softening located_in cerebrum has_material_basis_in injured or dead cells of the central nervous system. MESH:D004678 NCI:C98920 SNOMEDCT_US_2020_03_01:58762006 UMLS_CUI:C0014068 disease_ontology DOID:2034 encephalomalacia A connective tissue disease characterized by damage of tissues located_in the entheses, the site of insertion of tendons or ligaments into bones or joint capsules, with symptoms of pain, swelling and inflammation. ICD10CM:M77.9 ICD9CM:726.90 MESH:D000070676 SNOMEDCT_US_2020_03_01:278525009 UMLS_CUI:C0242490 disease_ontology DOID:204 enthesopathy MESH:D000070676 A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:12591 DOID:12592 DOID:2042 EFO:0004197 MESH:D006509 NCI:C3097 SNOMEDCT_US_2020_03_01:66071002 UMLS_CUI:C0019163 chronic hepatitis B hepatitis B infection disease_ontology Serum hepatitis DOID:2043 hepatitis B A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma. DOID:2046 MESH:D003699 SNOMEDCT_US_2020_03_01:424460009 UMLS_CUI:C0011226 delta hepatitis disease_ontology DOID:2047 hepatitis D An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells. DOID:4745 GARD:5871 ICD9CM:571.42 MESH:D019693 NCI:C27778 SNOMEDCT_US_2020_03_01:16098491000119109 UMLS_CUI:C0241910 UMLS_CUI:C1332355 Autoimmune Hepatitis Autoimmune chronic active hepatitis Autoimmune hepatitis autoimmune hepatitis with centrilobular necrosis disease_ontology DOID:2048 autoimmune hepatitis A bone remodeling disease that results in an abnormal growth of located in bone. ICD10CM:M89.3 MESH:D015576 NCI:C34712 SNOMEDCT_US_2020_03_01:13814009 UMLS_CUI:C0020492 bone hypertrophy hypertrophy of bone disease_ontology DOID:205 hyperostosis A maxillary sinusitis which lasts for less than 4 weeks. ICD10CM:J01.0 ICD9CM:461.0 SNOMEDCT_US_2020_03_01:155499007 UMLS_CUI:C0155804 acute antritis disease_ontology DOID:2050 acute maxillary sinusitis A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache. ICD10CM:J32.0 MESH:D015523 NCI:C34809 SNOMEDCT_US_2020_03_01:275484005 UMLS_CUI:C0024959 disease_ontology DOID:2051 maxillary sinusitis An anxiety disorder which results from a traumatic experience that results in psychological trauma. ICD10CM:F43.1 ICD9CM:309.81 MESH:D013313 NCI:C3389 SNOMEDCT_US_2020_03_01:192415000 UMLS_CUI:C0038436 PTSD traumatic neurosis disease_ontology post-traumatic stress disorder DOID:2055 post-traumatic stress disorder A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp. DOID:2056 GARD:12313 MESH:D002178 NCI:C34444 OMIM:114580 OMIM:212050 OMIM:607644 OMIM:613108 OMIM:613956 OMIM:614162 OMIM:615527 OMIM:616445 ORDO:1334 SNOMEDCT_US_2020_03_01:234568006 UMLS_CUI:C0006845 chronic Mucocutaneous Candidiasis disease_ontology DOID:2058 chronic mucocutaneous candidiasis A female reproductive system disease that is located_in the vulva. MESH:D014845 NCI:C27631 SNOMEDCT_US_2020_03_01:5089007 UMLS_CUI:C0042994 disease_ontology DOID:2059 vulvar disease disease_ontology Eccrine nodular hidradenoma nodular hidradenoma DOID:2061 nodular hidradenoma GARD:10547 MESH:D018252 NCI:C3761 OMIM:186600 SNOMEDCT_US_2020_03_01:189051001 UMLS_CUI:C0206673 disease_ontology DOID:2065 syringoma ICD9CM:569.83 MESH:D007416 NCI:C39611 SNOMEDCT_US_2020_03_01:56905009 UMLS_CUI:C0021845 Perforation of intestine disease_ontology DOID:2074 intestinal perforation A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces. ICD10CM:K59.0 ICD9CM:564.0 MESH:D003248 NCI:C37930 SNOMEDCT_US_2020_03_01:363693003 UMLS_CUI:C0009806 disease_ontology DOID:2089 constipation ICD10CM:M12.8 ICD9CM:716.4 NCI:C35761 SNOMEDCT_US_2020_03_01:66191007 UMLS_CUI:C0152083 disease_ontology DOID:2092 transient arthritis A vulva cancer that has_material_basis in melanocytes. NCI:C40329 SNOMEDCT_US_2020_03_01:254896002 UMLS_CUI:C0241989 malignant melanoma of vulva disease_ontology DOID:2093 vulvar melanoma ICD10CM:C44 NCI:C4810 SNOMEDCT_US_2020_03_01:255095005 UMLS_CUI:C1321904 malignant neoplasm of sweat gland malignant tumor of the Sweat gland disease_ontology DOID:2095 sweat gland cancer A vulva adenocarcinoma that is characterized by distinctive large cells with prominent cytoplasm, referred to as Paget cells and is an intraepithelial neoplasm of epithelial origin expressing apocrine or eccrine glandular-like features. NCI:C4027 SNOMEDCT_US_2020_03_01:254898001 UMLS_CUI:C1275217 Paget's disease of vulva Vulval Paget's disease Vulvar Paget's disease vulval Paget disease disease_ontology DOID:2097 vulval Paget's disease A vulva carcinoma that derives_from epithelial cells of glandular origin. NCI:C6380 UMLS_CUI:C1336975 adenocarcinoma of Vulva disease_ontology adenocarcinoma of the vulva DOID:2098 vulva adenocarcinoma A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres. GARD:12301 ICD9CM:359.22 MESH:D009224 NCI:C84912 OMIM:160800 OMIM:255700 ORDO:614 UMLS_CUI:C0027127 Congenital myotonia, autosomal dominant form Thomsen disease Thomsen's disease disease_ontology DOID:2106 OMIM mapping confirmed by DO. [SN]. myotonia congenita A coccidiosis that involves infection of the epithelial cells of the small intestine with Cystoisospora belli, which results in nonbloody diarrhea with crampy abdominal pain, malabsorption and weight loss. DOID:4891 ICD10CM:A07.3 MESH:D021865 NCI:C4076 SNOMEDCT_US_2020_03_01:73034009 UMLS_CUI:C0311386 Infection by Isospora belli and Isospora hominis Isosporosis isosporiasis disease_ontology DOID:2112 cystoisosporiasis A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection. MESH:D003048 NCI:C34493 SNOMEDCT_US_2020_03_01:186125004 UMLS_CUI:C0009187 Coccidiosis disease_ontology intestinal coccidiosis DOID:2113 coccidiosis A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly. DOID:6026 ICD9CM:279.03 SNOMEDCT_US_2020_03_01:190982008 UMLS_CUI:C0154276 B cell (antibody) deficiencies Immunoglobulin heavy chain deficiency immunoglobulin heavy chain deletion disease_ontology DOID:2115 B cell deficiency A syndrome characterized at birth by streaks of very thin skin (dermal hypoplasia), cutis aplasia, and telangiectases, and has_material_basis_in heterozygous mutation in the PORCN gene on chromosome Xp11.23. GARD:6457 MESH:D005489 NCI:C84715 OMIM:305600 ORDO:2092 SNOMEDCT_US_2020_03_01:205573006 UMLS_CUI:C0016395 FDH FODH Goltz syndrome Goltz-Gorlin syndrome disease_ontology DOID:2120 OMIM mapping confirmed by DO. [SN]. focal dermal hypoplasia A syndrome characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings. GARD:6317 ICD9CM:757.31 MESH:D004476 NCI:C84683 OMIM:PS305100 ORDO:79373 SNOMEDCT_US_2020_03_01:8654005 UMLS_CUI:C0013575 Congenital ectodermal defect Congenital ectodermal dysplasia disease_ontology DOID:2121 ectodermal dysplasia A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues. GARD:396 ICD9CM:021.8 SNOMEDCT_US_2020_03_01:186298002 UMLS_CUI:C0029835 disease_ontology DOID:2123 tularemia A brain cancer that is usually located in the brain, but can occur anywhere in the central nervous system. NCI:C6906 OMIM:609322 ORDO:99966 SNOMEDCT_US_2020_03_01:128792003 UMLS_CUI:C1266184 Atypical teratoid/rhabdoid tumor Atypical teratoid/rhabdoid tumour Rhabdoid tumor of the CNS Rhabdoid tumour of the CNS atypical teratoid rhabdoid tumour disease_ontology AT/RT rhabdoid tumor predisposition syndrome DOID:2129 OMIM mapping confirmed by DO. [SN]. atypical teratoid rhabdoid tumor ICD10CM:K03.8 ICD9CM:521.8 SNOMEDCT_US_2020_03_01:197505001 UMLS_CUI:C0029770 disease_ontology DOID:214 teeth hard tissue disease An extrapulmonary tuberculosis that is located_in urogenital system. ICD10CM:A18.1 ICD9CM:016 MESH:D014401 SNOMEDCT_US_2020_03_01:4445009 UMLS_CUI:C0041333 disease_ontology Genitourinary tuberculosis DOID:2149 urogenital tuberculosis An ovary epithelial cancer that has_material_basis_in epithelial and stromal tissue and arises from the surface epithelium of the ovary. NCI:C40026 UMLS_CUI:C1518236 disease_ontology DOID:2151 malignant ovarian surface epithelial-stromal neoplasm An ovarian cancer that is derives_from ovarian surface epithelium. NCI:C4381 SNOMEDCT_US_2020_03_01:237057005 UMLS_CUI:C0341823 Ovarian Surface epithelial-Stromal tumor disease_ontology DOID:2152 ovary epithelial cancer A kidney cancer that affects the kidneys and typically located_in children. DOID:5177 DOID:5180 ICDO:M8960/3 MESH:D009396 NCI:C27730 NCI:C3267 NCI:C6180 OMIM:194070 SNOMEDCT_US_2020_03_01:25081006 UMLS_CUI:C0027708 UMLS_CUI:C1332219 UMLS_CUI:C1333015 adult nephroblastoma disease_ontology Wilms' tumor DOID:2154 OMIM mapping confirmed by DO. [SN]. nephroblastoma An ovarian cancer that originates in the germ (egg) cells of the ovary. GARD:9330 NCI:C3873 OMIM:603737 SNOMEDCT_US_2020_03_01:237059008 UMLS_CUI:C0238324 germ cell neoplasm of Ovary germ cell tumor of ovary disease_ontology ovarian germ cell tumor DOID:2156 OMIM mapping confirmed by DO. [SN]. ovarian germ cell cancer A teeth hard tissue disease that is characterized by damage to a tooth that can happen when decay-causing bacteria in your mouth make acids that attack the tooth’s surface, or enamel. DOID:10785 DOID:10870 DOID:11913 EFO:0003819 ICD10CM:K02 ICD10CM:K02.6 ICD9CM:521.0 ICD9CM:521.07 MESH:D003731 NCI:C52593 SNOMEDCT_US_2020_03_01:155632007 UMLS_CUI:C0011334 UMLS_CUI:C1456145 Dental caries extending into pulp Dental caries of smooth surface Dental caries pit and fissure disease_ontology DOID:216 dental caries DOID:4728 NCI:C27102 SNOMEDCT_US_2020_03_01:232340005 UMLS_CUI:C0339820 disease_ontology DOID:2163 nasal cavity disease ICD9CM:521.01 SNOMEDCT_US_2020_03_01:80353004 UMLS_CUI:C0266853 Dental caries limited to enamel primary dental caries simple dental cavity disease_ontology DOID:217 enamel caries A vaginal disease that is characterized by inflammation of the vagina. DOID:10769 ICD9CM:616.1 MESH:D014627 NCI:C26911 SNOMEDCT_US_2020_03_01:198212006 SNOMEDCT_US_2020_03_01:393596009 UMLS_CUI:C0042267 UMLS_CUI:C0042268 disease_ontology DOID:2170 vaginitis A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye. DOID:9985 ICD9CM:190.8 MESH:D005134 NCI:C3030 SNOMEDCT_US_2020_03_01:126995000 SNOMEDCT_US_2020_03_01:188277006 UMLS_CUI:C0015414 UMLS_CUI:C0153632 Ocular tumor eye neoplasm malignant eye neoplasm neoplasm of eye neoplasm of eye proper disease_ontology DOID:2174 ocular cancer ICD10CM:C18.2 ICD9CM:153.6 SNOMEDCT_US_2020_03_01:93683002 UMLS_CUI:C0153439 Ca ascending colon malignant neoplasm of right colon malignant tumor of ascending colon disease_ontology DOID:218 ascending colon cancer A dental enamel hypoplasia characterized by abnormal enamel formation. GARD:5791 ICD10CM:K00.5 MESH:D000567 OMIM:PS104500 ORDO:88661 SNOMEDCT_US_2020_03_01:78494001 UMLS_CUI:C0002452 disease_ontology DOID:2187 Xref MGI. amelogenesis imperfecta A colorectal cancer that is located_in the colon. ICD10CM:C18 ICD9CM:153 MESH:D003110 NCI:C9242 SNOMEDCT_US_2020_03_01:363406005 UMLS_CUI:C0007102 disease_ontology DOID:219 colon cancer A blood coagulation disease that is characterized by easy bleeding, has_symptom prolonged umbilical cord bleeding, epistaxis, bleeding of the gums, menorrhagia, recurrent miscarriages, abnormal scar formation and wound healing, and hemarthrosis, and has_material_basis_in autosomal recessive inheritance of mutation of the F13A1 or F13B gene, which encodes Factor XIII, formally known as fibrin stabilizing factor. GARD:10766 MESH:D005177 NCI:C98941 OMIM:613225 OMIM:613235 SNOMEDCT_US_2020_03_01:50189006 UMLS_CUI:C0015530 Factor XIII deficiency disease Hereditary factor XIII deficiency disease deficiency, Laki-Lorand factor disease_ontology DOID:2211 OMIM mapping confirmed by DO. [SN]. factor XIII deficiency ICD10CM:D69.9 ICD9CM:287.9 MESH:D006474 SNOMEDCT_US_2020_03_01:268884000 UMLS_CUI:C0019087 Hemorrhagic diathesis Hemorrhagic disease disease_ontology DOID:2213 hemorrhagic disease A blood coagulation disease that is characterized by easy bleeding, has_symptom epistaxis, bleeding of the gums, menorrhagia, and occasionally hemarthrosis, and has_material_basis_in autosomal recessive inheritance of mutation in the F7 gene, which encodes coagulation factor VII, an important factor in the clotting cascade. GARD:2238 ICD10CM:D68.2 MESH:D005168 NCI:C131631 SNOMEDCT_US_2020_03_01:154820003 UMLS_CUI:C0015503 Factor VII deficiency deficiency, stable disease_ontology DOID:2215 factor VII deficiency GARD:2237 ICD10CM:D68.2 MESH:D005166 NCI:C98938 OMIM:227400 SNOMEDCT_US_2020_03_01:191284007 UMLS_CUI:C0015499 Hereditary hypoproaccelerinaemia Labile factor deficiency Proaccelerin deficiency deficiency, labile disease_ontology DOID:2216 OMIM mapping confirmed by DO. [SN]. factor V deficiency A blood coagulation disease characterized by autosomal recessive inheritance of mucosal bleeding, purpuric skin bleeding, epistaxis, and menorrhagia with prolonged bleeding times, enlarged platelets and absence of platelet aggregation in response to von Willebrand factor that has material_basis_in mutation in the GP1BA gene, the GP1BB gene, or the GP9 gene which are subunits of the platelet membrane von Willebrand factor receptor complex, glycoprotein Ib. MESH:D001606 NCI:C84595 OMIM:231200 ORDO:274 SNOMEDCT_US_2020_03_01:54569005 UMLS_CUI:C0005129 Bernard - Soulier thrombopathy Bernard Soulier syndrome Giant platelet syndrome Hemorrhagic dystrophic thrombocytopenia Thrombopathy, Bernard-Soulier disease_ontology DOID:2217 OMIM mapping confirmed by DO. [SN]. Bernard-Soulier syndrome A blood coagulation disease that is characterized by an abnormal increase or decrease in platelets or platelet dysfunction. MESH:D001791 NCI:C131634 SNOMEDCT_US_2020_03_01:22716005 UMLS_CUI:C0005818 Thrombocytopathy platelet disorder disease_ontology DOID:2218 blood platelet disease A blood coagulation disease characterized by autosomal recessive inheritance of failure of platelet aggregation and absent or diminished clot retraction that has material_basis_in mutation in the ITGA2B or ITGB3 genes on chromosome 17q21.32. GARD:2478 ICD10CM:D69.1 MESH:D013915 NCI:C61249 OMIM:273800 ORDO:849 SNOMEDCT_US_2020_03_01:32942005 UMLS_CUI:C0040015 BDPLT2 Glanzmann thrombasthenia Glycoprotein IIb/IIIa defect Thrombocytasthenia deficiency of GP IIb-IIIa complex deficiency of glycoprotein complex IIb-IIIa deficiency of platelet fibrinogen receptor platelet glycoprotein IIb-IIIa deficiency platelet-type bleeding disorder 2 thrombasthenia of Glanzmann and Naegeli disease_ontology DOID:2219 OMIM mapping confirmed by DO. [LS]. Glanzmann's thrombasthenia A blood coagulation disease that is characterized by the partial or complete absence of factor X activity in the blood. GARD:6404 MESH:D005171 NCI:C131632 SNOMEDCT_US_2020_03_01:76642003 UMLS_CUI:C0015519 Factor X deficiency disease, Stuart-Prower disease_ontology DOID:2222 factor X deficiency GARD:5034 MESH:D010981 OMIM:185050 SNOMEDCT_US_2020_03_01:234474009 UMLS_CUI:C0032197 Dense body defect Platelet dense granule deficiency Platelet storage pool defect disease_ontology DOID:2223 platelet storage pool deficiency A myeloproliferative neoplasm that is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage and that results_in the overproduction of platelets. GARD:6594 ICD10CM:D47.3 ICD9CM:238.71 MESH:D013920 NCI:C3407 OMIM:187950 OMIM:601977 OMIM:614521 ORDO:3318 ORDO:71493 SNOMEDCT_US_2020_03_01:234499005 UMLS_CUI:C0040028 Essential thrombocythaemia familial thrombocytosis hemorrhagic thrombocythemia hereditary thrombocythemia primary Thrombocytosis disease_ontology DOID:2224 Xref MGI. OMIM mapping confirmed by DO. [SN]. essential thrombocythemia A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood. DOID:6002 ICD10CM:D47.1 NCI:C4345 SNOMEDCT_US_2020_03_01:115248004 UMLS_CUI:C1292778 CMPD CMPD, U chronic myeloproliferative disease disease_ontology DOID:2226 myeloproliferative neoplasm A blood platelet disease that is characterized by the presence of high platelet counts in the blood. MESH:D013922 NCI:C35530 SNOMEDCT_US_2020_03_01:165557006 UMLS_CUI:C0836924 Thrombocythaemia disease_ontology DOID:2228 thrombocytosis A blood coagulation disease that is characterized by deficiency of factor XI clotting factor and mild prolonged bleeding, especially of mucosal sites following trauma, and has_material_basis_in homozygous, compound heterozygous, or heterozygous mutation of the coagulation factor XI gene of chromosome 4q35.2. GARD:9670 ICD10CM:D68.1 ICD9CM:286.2 MESH:D005173 NCI:C84705 OMIM:612416 SNOMEDCT_US_2020_03_01:49762007 UMLS_CUI:C0015523 Congenital factor XI deficiency Hereditary factor XI deficiency disease Rosenthal's disease hemophilia C plasma thromboplastin antecedent deficiency disease_ontology DOID:2229 OMIM mapping confirmed by DO. [SN]. factor XI deficiency A blood coagulation disease that is characterized by prolonged PTT time without clinical symptoms, and has_material_basis_in a mutation in the F12 gene on chromosome 5q33. GARD:6558 MESH:D005175 NCI:C131740 OMIM:234000 ORDO:330 SNOMEDCT_US_2020_03_01:46981006 UMLS_CUI:C0015526 Factor XII deficiency disease Hageman Factor deficiency deficiency, Hageman disease_ontology DOID:2231 OMIM mapping confirmed by DO. [SN]. factor XII deficiency An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response. MESH:D004828 NCI:C122812 SNOMEDCT_US_2020_03_01:230381009 UMLS_CUI:C0014547 localisation-related epilepsy partial epilepsy disease_ontology DOID:2234 focal epilepsy A blood coagulation disease that is characterized by an impaired blood clotting resulting from a lack deficiency of a the fibrinogen protein (coagulation factor I). GARD:5761 MESH:D000347 NCI:C98130 OMIM:202400 SNOMEDCT_US_2020_03_01:278504009 UMLS_CUI:C0001733 Factor I deficiency Fibrinogen deficiency disease_ontology DOID:2236 OMIM mapping confirmed by DO. [SN]. congenital afibrinogenemia DOID:12352 DOID:14551 DOID:1706 DOID:1707 DOID:2238 ICD10CM:K73.9 ICD9CM:570 ICD9CM:571.4 ICD9CM:571.41 MESH:D006521 NCI:C82978 SNOMEDCT_US_2020_03_01:155813004 SNOMEDCT_US_2020_03_01:197268000 SNOMEDCT_US_2020_03_01:266539002 UMLS_CUI:C0001308 UMLS_CUI:C0019189 UMLS_CUI:C0149519 acute and subacute liver necrosis acute hepatitis acute/subac. necrosis of liver animal hepatitis chronic hepatitis chronic persistent hepatitis disease_ontology DOID:2237 hepatitis A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death. DOID:2315 ICD10CM:G45.9 MESH:D002546 NCI:C50781 SNOMEDCT_US_2020_03_01:195196001 UMLS_CUI:C0007787 TIA TIA - Transient ischaemic attack TRANSIENT ISCHEMIC ATTACK Transient cerebral ischaemia Transient cerebral ischemia Transient ischemic attacks transient ischemic attack disease_ontology DOID:224 transient cerebral ischemia An bone structure disease that involves degeneration between vertebra located_in vertebral column. DOID:8708 DOID:8709 DOID:8888 DOID:8905 DOID:9949 ICD10CM:M47 ICD9CM:721.9 MESH:D055009 OMIM:184300 SNOMEDCT_US_2020_03_01:8847002 UMLS_CUI:C0038019 Lumbar spondylosis with myelopathy Spondylogenic compression of lumbar spinal cord Spondylogenic compression of thoracic spinal cord Spondylosis with myelopathy Thoracic or lumbar spondylosis with myelopathy lumbosacral spondylosis without myelopathy spondylosis with myelopathy disease_ontology DOID:2247 spondylosis A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality. MESH:D013577 NCI:C28193 SNOMEDCT_US_2020_03_01:64572001 UMLS_CUI:C0039082 disease_ontology DOID:225 syndrome A uterine disease that is located_in the cervix. MESH:D002577 NCI:C40241 SNOMEDCT_US_2020_03_01:63339007 UMLS_CUI:C0007867 disease_ontology DOID:2253 cervix disease A bone development disease that results_in defective development of cartilage or bone. DOID:1764 ICD10CM:Q78.9 ICD9CM:756.4 MESH:D010009 NCI:C34466 NCI:C84978 SNOMEDCT_US_2020_03_01:205510001 SNOMEDCT_US_2020_03_01:67988000 UMLS_CUI:C0008449 UMLS_CUI:C0029422 Cartilage Development disorder Congenital anomaly of cartilage Osteochondrodysplasia syndrome chondrodystrophy skeletal dysplasia disease_ontology DOID:2256 osteochondrodysplasia Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself. ICD10CM:M24.6 ICD9CM:718.5 MESH:D000844 SNOMEDCT_US_2020_03_01:36504009 UMLS_CUI:C0003090 disease_ontology DOID:227 ankylosis MESH:D000844 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge. ICD10CM:B37.3 ICD9CM:112.1 MESH:D002181 NCI:C2914 SNOMEDCT_US_2020_03_01:154404004 UMLS_CUI:C0700345 Candidal vulvovaginitis Candidal: cervix Candidiasis of vulva and vagina Monilial vulvovaginitis Vulvovaginal Candidiasis disease_ontology DOID:2272 vulvovaginal candidiasis An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as sore throat. The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever. DOID:10455 DOID:11586 DOID:11588 DOID:938 DOID:939 ICD10CM:J02 ICD9CM:462 ICD9CM:472 ICD9CM:478.20 MESH:D010608 MESH:D010612 NCI:C26850 NCI:C26851 NCI:C34355 SNOMEDCT_US_2020_03_01:195654001 SNOMEDCT_US_2020_03_01:195763009 SNOMEDCT_US_2020_03_01:37616004 SNOMEDCT_US_2020_03_01:75860007 UMLS_CUI:C0001344 UMLS_CUI:C0031345 UMLS_CUI:C0031350 UMLS_CUI:C0155824 Inflamed throat Persistent sore throat Pharyngeal disorder Pharyngitis - acute Sore throat - chronic acute pharyngitis acute sore throat chronic pharyn/nasopharyngitis chronic pharyngitis chronic pharyngitis and nasopharyngitis chronic sore throat disease_ontology pharyngeal disease DOID:2275 pharyngitis An endocrine system disease that is located_in the gonads. MESH:D006058 NCI:C26786 UMLS_CUI:C0018050 disease_ontology DOID:2277 gonadal disease A hidradenitis that is characterized by chronic inflammation of the apocrine sweat glands, has_symptom painful nodules, abscesses, sinus tract formation, scarring, erythema, pruritis, and pain, and has_material_basis_in chronic inflammation of the apocrine sweat glands leading to recurrent folliculitis and an accompanying immune response that worsens inflammation. GARD:6658 ICD10CM:L73.2 MESH:D017497 NCI:C128429 OMIM:142690 OMIM:613736 OMIM:613737 SNOMEDCT_US_2020_03_01:201204008 UMLS_CUI:C0162836 Acne inversa, familial Hidradenitis suppurativa disease_ontology DOID:2280 OMIM mapping confirmed by DO. [SN]. hidradenitis suppurativa A sweat gland disease that is characterized by inflammation of the apocrine sweat glands and has_symptom erythema, edema, papules, plaques, pruritis, and pain. ICD9CM:705.83 MESH:D016575 NCI:C112190 SNOMEDCT_US_2020_03_01:267866004 UMLS_CUI:C0085160 Hidradenitis Hydradenitis disease_ontology DOID:2282 hidradenitis NCI:C27012 UMLS_CUI:C0235270 disease_ontology DOID:2283 keratopathy A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes. ICD9CM:629.9 MESH:D005831 SNOMEDCT_US_2020_03_01:38233001 UMLS_CUI:C0017411 disease_ontology DOID:229 female reproductive system disease A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly. DOID:11348 GARD:7881 ICD10CM:A27 ICD10CM:A27.0 ICD9CM:100 ICD9CM:100.0 MESH:D007922 MESH:D014895 NCI:C84825 SNOMEDCT_US_2020_03_01:154391003 SNOMEDCT_US_2020_03_01:398067003 UMLS_CUI:C0023364 UMLS_CUI:C0043102 Fort Bragg fever Leptospirosis icterohaemorrhagica Rat Catcher's Yellows Weil's disease nanukayami fever spirochetal jaundice disease_ontology DOID:2297 leptospirosis A motor neuron disease characterized by painless but progressive weakness and stiffness of the muscles of the legs. ICD10CM:G12.23 ICD9CM:335.24 MESH:D016472 NCI:C129933 OMIM:611637 ORDO:35689 SNOMEDCT_US_2020_03_01:81211007 UMLS_CUI:C0154682 adult-onset primary lateral sclerosis primary lateral sclerosis disease_ontology DOID:230 Xref MGI. lateral sclerosis A bone structure disease that involves a defect located_in lumbar vertebral column. ICD10CM:M43.0 MESH:D013169 NCI:C35034 SNOMEDCT_US_2020_03_01:203688008 UMLS_CUI:C0038018 disease_ontology DOID:2300 spondylolysis A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking. ICD10CM:F98.4 ICD9CM:307.3 MESH:D019956 SNOMEDCT_US_2020_03_01:5507002 UMLS_CUI:C0038273 Stereotyped repetitive movements Stereotypy habit disorder disease_ontology DOID:2303 stereotypic movement disorder A neurodegenerative disease that is located_in the motor neurones. ICD10CM:G12.2 ICD9CM:335.2 MESH:D016472 SNOMEDCT_US_2020_03_01:37340000 UMLS_CUI:C0085084 disease_ontology DOID:231 motor neuron disease An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy. GARD:7210 ICD10CM:A43 MESH:D009617 SNOMEDCT_US_2020_03_01:29227009 UMLS_CUI:C0028242 Nocardia infectious disease disease_ontology DOID:2312 nocardiosis An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand. MESH:D002545 SNOMEDCT_US_2020_03_01:193049009 UMLS_CUI:C0007786 Ischaemic encephalopathy Ischemic encephalopathy cerebral ischemia disease_ontology DOID:2316 brain ischemia A lung disease that is characterized by narrowing of pulmonary airways. MESH:D008173 UMLS_CUI:C0600260 respiratory airway obstruction disease_ontology DOID:2320 obstructive lung disease A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen. DOID:4094 DOID:5269 ICD10CM:K52.9 MESH:D005759 NCI:C34632 SNOMEDCT_US_2020_03_01:154278002 UMLS_CUI:C0017160 cholera morbus infectious colitis, enteritis and gastroenteritis disease_ontology DOID:2326 gastroenteritis MESH:D005759 A jaw cancer and mandibular disease that affects your lower jawbone. DOID:12408 ICD10CM:C41.1 ICD9CM:170.1 MESH:D008339 NCI:C35178 SNOMEDCT_US_2020_03_01:126551000 SNOMEDCT_US_2020_03_01:448668007 UMLS_CUI:C0024694 UMLS_CUI:C0153511 malignant neoplasm of inferior maxilla malignant neoplasm of lower Jaw bone mandible cancer neoplasm of mandible disease_ontology malignant neoplasm of mandible mandibular neoplasm DOID:2338 mandibular cancer A synostosis that results_in premature fusion located_in skull. GARD:6209 ICD10CM:Q75.0 MESH:D003398 NCI:C84655 OMIM:123100 OMIM:182212 OMIM:600593 OMIM:600775 OMIM:604757 OMIM:615314 ORDO:1531 SNOMEDCT_US_2020_03_01:205414007 UMLS_CUI:C0010278 Premature closure of cranial sutures disease_ontology DOID:2340 Xref MGI. OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS]. craniosynostosis ICD10CM:D89.0 ICD9CM:273.0 NCI:C35885 SNOMEDCT_US_2020_03_01:190808009 UMLS_CUI:C0154254 Polyclonal hypergammaglobulinemia disease_ontology DOID:2344 polyclonal hypergammaglobulinemia An inherited metabolic disorder that involves plasma protein metabolism malfunction. ICD9CM:273.8 SNOMEDCT_US_2020_03_01:190822009 UMLS_CUI:C0029594 disease_ontology DOID:2345 plasma protein metabolism disease ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C34403 NCI:C35768 SNOMEDCT_US_2020_03_01:155414001 SNOMEDCT_US_2020_03_01:39468009 UMLS_CUI:C0004153 UMLS_CUI:C3665365 Cardiovascular arteriosclerosis disease_ontology DOID:2348 arteriosclerotic cardiovascular disease An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries. ICD10CM:I70 MESH:D001161 NCI:C34398 SNOMEDCT_US_2020_03_01:195251000 UMLS_CUI:C0003850 Arteriosclerosis Arteriosclerotic vascular disease disease_ontology DOID:2349 arteriosclerosis An intestinal benign neoplasm that is located_in the colon. MESH:D003110 NCI:C2953 SNOMEDCT_US_2020_03_01:126838000 UMLS_CUI:C0009375 Colonic Mass Colonic tumor colon neoplasm neoplasm of colon disease_ontology DOID:235 colonic benign neoplasm ICD10CM:E83.1 ICD9CM:275.0 MESH:D019189 SNOMEDCT_US_2020_03_01:30913008 UMLS_CUI:C0012715 Iron disorder disorder of iron metabolism iron disorder disease_ontology DOID:2351 iron metabolism disease A metal metabolism disorder characterized by the accumulation of iron in various organs of the body. ICD10CM:E83.11 MESH:D006432 NCI:C84481 OMIM:231100 OMIM:PS235200 ORDO:139498 SNOMEDCT_US_2020_03_01:86781004 UMLS_CUI:C0018995 Haemochromatosis diabetes bronze iron storage disorder disease_ontology DOID:2352 Xref MGI. hemochromatosis An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas. ICD10CM:D61.82 MESH:D000750 SNOMEDCT_US_2020_03_01:2694001 UMLS_CUI:C0002890 ANEMIA LEUKOERYTHROBLASTIC Anemia, leukoerythroblastic Leukoerythroblastosis disease_ontology myelophthisis DOID:2354 myelophthisic anemia A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells. EFO:0004272 ICD10CM:D64.9 ICD9CM:285.9 MESH:D000740 NCI:C2869 SNOMEDCT_US_2020_03_01:64593003 UMLS_CUI:C0002871 anaemia disease_ontology DOID:2355 PRISM. anemia MESH:D000740 MESH:D000748 NCI:C34381 SNOMEDCT_US_2020_03_01:83414005 UMLS_CUI:C0002886 ANEMIA MACROCYTIC Macrocytic anaemia disease_ontology DOID:2361 macrocytic anemia A viral infectious disease that results in inflammation located in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis. GARD:9959 ICD10CM:A92.31 ICD9CM:066.41 MESH:D014901 SNOMEDCT_US_2020_03_01:392662004 UMLS_CUI:C0751583 West Nile Fever with encephalitis West Nile fever encephalitis disease_ontology DOID:2365 West Nile encephalitis A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting. ICD10CM:A92.3 ICD9CM:066.4 MESH:D014901 SNOMEDCT_US_2020_03_01:12381007 UMLS_CUI:C0043124 disease_ontology DOID:2366 West Nile fever MESH:D019150 NCI:C161542 SNOMEDCT_US_2020_03_01:230365004 UMLS_CUI:C0338473 disease_ontology DOID:2367 neuroaxonal dystrophy A sphingolipidosis that is characterized by the accumulation of lipids known as gangliosides. GARD:12510 ICD10CM:E75.10 MESH:D005733 ORDO:309144 SNOMEDCT_US_2020_03_01:50967008 UMLS_CUI:C0017083 disease_ontology DOID:2368 gangliosidosis A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present. GARD:6621 ICD10CM:D58.1 ICD9CM:282.1 MESH:D004612 NCI:C35882 OMIM:130600 OMIM:611804 ORDO:288 SNOMEDCT_US_2020_03_01:154801000 UMLS_CUI:C0013902 Congenital elliptocytosis ovalocytosis disease_ontology DOID:2373 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary elliptocytosis A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. EFO:0003885 GARD:10255 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 SNOMEDCT_US_2020_03_01:155023009 UMLS_CUI:C0026769 Generalized multiple sclerosis insular sclerosis disease_ontology DOID:2377 OMIM mapping confirmed by DO. [LS]. multiple sclerosis MESH:D009103 A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction. GARD:6830 ICD10CM:P57 MESH:D007647 NCI:C84799 SNOMEDCT_US_2020_03_01:157135006 UMLS_CUI:C0022610 bilirubin encephalopathy disease_ontology DOID:2382 kernicterus A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant. ICD10CM:P59.9 MESH:D007567 NCI:C99246 SNOMEDCT_US_2020_03_01:299968002 UMLS_CUI:C0022353 neonatal hyperbilirubinemia neonatal icterus disease_ontology DOID:2383 neonatal jaundice A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1). ICD10CM:E51.2 MESH:D014899 SNOMEDCT_US_2020_03_01:190627001 UMLS_CUI:C0043121 Wernicke's disease Wernicke's encephalopathy disease_ontology DOID:2384 Wernicke encephalopathy ICD9CM:593.81 NCI:C35338 SNOMEDCT_US_2020_03_01:16934004 UMLS_CUI:C0268790 renal vascular disease vascular disorder of kidney disease_ontology DOID:2388 renal artery disease A female reproductive organ cancer that is located_in the ovary. DOID:0060070 DOID:2144 DOID:9595 GARD:7295 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 SNOMEDCT_US_2020_03_01:123843001 SNOMEDCT_US_2020_03_01:372117006 SNOMEDCT_US_2020_03_01:93934004 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247 malignant Ovarian tumor malignant tumour of ovary ovarian neoplasm ovary neoplasm primary ovarian cancer tumor of the Ovary disease_ontology DOID:2394 Xref MGI. OMIM mapping confirmed by DO. [SN]. ovarian cancer MESH:D007499 NCI:C34737 SNOMEDCT_US_2020_03_01:85478004 UMLS_CUI:C0022078 disease_ontology DOID:240 iris disease GARD:9618 MESH:D016586 NCI:C3474 SNOMEDCT_US_2020_03_01:12169001 UMLS_CUI:C0085167 neoplasm of granular cell disease_ontology DOID:2411 granular cell tumor NCI:C4481 SNOMEDCT_US_2020_03_01:254766004 UMLS_CUI:C0346063 Cutaneous Ganglioneuroma Ganglioneuroma of skin disease_ontology DOID:2425 cutaneous ganglioneuroma A central nervous system benign neoplasm that has_material_basis_in mature neurons, and is classified by the absence of neoplastic glial cells. GARD:10638 MESH:D005729 NCI:C6934 SNOMEDCT_US_2020_03_01:78268004 gangliocytoma of central nervous system disease_ontology DOID:2426 gangliocytoma NCI:C4463 SNOMEDCT_US_2020_03_01:126489007 UMLS_CUI:C0345988 neoplasm of skin with adnexal differentiation neoplasm of the skin Appendage skin appendage tumour disease_ontology DOID:2433 epidermal appendage tumor MESH:D005918 NCI:C4222 SNOMEDCT_US_2020_03_01:7429002 UMLS_CUI:C0334421 disease_ontology DOID:2436 glomangioma NCI:C4475 SNOMEDCT_US_2020_03_01:254735005 UMLS_CUI:C0346041 dermis tumour neoplasm of Dermis tumor of dermis tumour of dermis disease_ontology DOID:2438 dermis tumor MESH:D006964 SNOMEDCT_US_2020_03_01:10649000 UMLS_CUI:C0020506 disease_ontology DOID:2444 hyperpituitarism MESH:D006964 A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb. GARD:5725 MESH:D000172 NCI:C84533 SNOMEDCT_US_2020_03_01:154698000 UMLS_CUI:C0001206 disease_ontology DOID:2449 acromegaly ICD10CM:H34.81 ICD9CM:362.35 MESH:D012170 NCI:C118859 SNOMEDCT_US_2020_03_01:193378003 UMLS_CUI:C0154841 disease_ontology DOID:2450 central retinal vein occlusion GARD:4524 ICD10CM:D68.59 MESH:D018455 NCI:C99026 SNOMEDCT_US_2020_03_01:1563006 UMLS_CUI:C0242666 Protein S deficiency Protein S deficiency disease disease_ontology DOID:2451 protein S deficiency A blood coagulation disease that is characterized by an increased tendency to form clots. ICD10CM:D68.59 MESH:D019851 NCI:C84479 OMIM:PS188050 SNOMEDCT_US_2020_03_01:191302007 UMLS_CUI:C0398623 hypercoagulability state disease_ontology DOID:2452 OMIM mapping confirmed by DO. [LS]. thrombophilia MESH:D019851 NCI:C35170 SNOMEDCT_US_2020_03_01:57534004 UMLS_CUI:C0154833 retina circulation disorder disease_ontology DOID:2462 retinal vascular disease A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. EFO:0000677 ICD9CM:298.8 UMLS_CUI:C0029516 mental or behavioural disorder disease_ontology DOID:2468 psychotic disorder A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices. DOID:0050137 ICD9CM:118 SNOMEDCT_US_2020_03_01:78999002 UMLS_CUI:C0029119 Opportunistic mycoses Opportunistic mycosis opportunistic systemic mycoses disease_ontology DOID:2473 opportunistic mycosis ICD10CM:H10.4 ICD9CM:372.1 NCI:C35197 SNOMEDCT_US_2020_03_01:155163007 UMLS_CUI:C0155145 chronic Conjunctivitis disease_ontology DOID:2475 chronic conjunctivitis ICD10CM:G60.0 MESH:D015417 NCI:C75467 SNOMEDCT_US_2020_03_01:128202008 UMLS_CUI:C0027888 HSMN HSMN - Hereditary sensory and motor neuropathy Hereditary motor and sensory neuropathy neuropathic muscular atrophy disease_ontology DOID:2477 motor peripheral neuropathy A brain disease that is characterized by vertigo caused by hemorrhagic insult, ischemic insult or mass lesion of the cerebellum, the vestibular nuclei, and the brainstem, has_symptom dizziness, has_symptom nausea, has_symptom vomiting and has_symptom difficulty walking. ICD10CM:H81.4 ICD9CM:386.2 MESH:D014717 SNOMEDCT_US_2020_03_01:20425006 UMLS_CUI:C0155503 Vertigo of central origin central vestibular vertigo disease_ontology DOID:2479 central nervous system origin vertigo A respiratory system benign neoplasm that derives_from smooth muscle cells and is located_in the trachea. DOID:246 MESH:D014134 NCI:C3419 NCI:C6049 SNOMEDCT_US_2020_03_01:126703006 UMLS_CUI:C0040582 UMLS_CUI:C1336772 leiomyoma of the Trachea disease_ontology DOID:248 trachea leiomyoma ICD9CM:275.3 MESH:D010760 NCI:C97095 SNOMEDCT_US_2020_03_01:190858002 UMLS_CUI:C0031707 Phosphorus disorder disorder of phosphorus metabolism phosphorus metabolism disorder disease_ontology DOID:2485 phosphorus metabolism disease ICD9CM:742 SNOMEDCT_US_2020_03_01:204018008 UMLS_CUI:C0158538 congenital neurologic anomaly disease_ontology DOID:2490 congenital nervous system abnormality A neuropathy that involves damage to nerves of the peripheral nervous system. DOID:10596 ICD9CM:356.2 MESH:D009477 NCI:C3501 SNOMEDCT_US_2020_03_01:193163001 SNOMEDCT_US_2020_03_01:95662005 UMLS_CUI:C0151313 UMLS_CUI:C0699739 Sensory neuropathy peripheral Sensory Neuropathy sensory neuropathy disease_ontology DOID:2491 sensory peripheral neuropathy MESH:D020252 NCI:C84724 SNOMEDCT_US_2020_03_01:412795008 UMLS_CUI:C0267211 Watermelon stomach disease_ontology DOID:2493 gastric antral vascular ectasia A vascular disease that is characterized as a small vascular malformation of the gut. DOID:12071 MESH:D016888 SNOMEDCT_US_2020_03_01:71072006 UMLS_CUI:C0085411 angiodysplasia of stomach and duodenum with hemorrhage disease_ontology DOID:2494 angiodysplasia MESH:D016888 NCI:C4390 SNOMEDCT_US_2020_03_01:5050001 UMLS_CUI:C0343082 Senile hemangioma Senile naevus of skin disease_ontology DOID:2495 senile angioma ICD9CM:521.31 UMLS_CUI:C1456161 disease_ontology DOID:2497 enamel erosion DOID:11509 DOID:12687 ICD10CM:K03.2 ICD9CM:521.3 MESH:D014077 SNOMEDCT_US_2020_03_01:82212003 UMLS_CUI:C0040436 generalized erosion localized erosion disease_ontology DOID:2498 tooth erosion A vasculitis that involves inflammation of the aorta that carries blood from the heart to the rest of the body. DOID:13377 GARD:7730 ICD10CM:M31.4 ICD9CM:446.7 MESH:D001015 MESH:D013625 NCI:C34391 NCI:C35062 OMIM:207600 SNOMEDCT_US_2020_03_01:359789008 SNOMEDCT_US_2020_03_01:42153001 UMLS_CUI:C0003490 UMLS_CUI:C0039263 Aortic Arch syndrome Aortic arch arteritis Aortic arch syndrome Idiopathic aortitis Takayasu arteritis Takayasu's disease disease_ontology DOID:2508 OMIM mapping confirmed by DO. [SN]. Takayasu's arteritis ICD9CM:291.89 UMLS_CUI:C1456283 disease_ontology DOID:251 alcohol-induced mental disorder A syndrome characterized by multiple early-onset basal cell carcinoma, multiple jaw keratocysts and skeletal abnormalities that has_material_basis_in heterozygous mutation in either PTCH1, PTCH2, or SUFU on chromosome 9q22, 1p32, or 10q24-q25, respectively. GARD:7166 MEDDRA:10062804 MESH:D001478 NCI:C2892 OMIM:109400 ORDO:377 SNOMEDCT_US_2020_03_01:69408002 UMLS_CUI:C0004779 Gorlin syndrome NBCCS basal cell nevus syndrome disease_ontology DOID:2512 OMIM mapping confirmed by DO. [SN]. nevoid basal cell carcinoma syndrome A skin carcinoma affecting basal cells. DOID:4275 DOID:4276 EFO:0004193 KEGG:05217 MESH:D018295 NCI:C156767 NCI:C3784 NCI:C7586 SNOMEDCT_US_2020_03_01:127570002 SNOMEDCT_US_2020_03_01:154507009 SNOMEDCT_US_2020_03_01:252995000 UMLS_CUI:C0007117 UMLS_CUI:C0206710 UMLS_CUI:C1368295 Basal cell cancer Basal cell carcinoma of skin Basal cell neoplasm Basal cell tumor Epithelioma basal cell Rodent ulcer malignant Basal cell neoplasm malignant basal cell tumor disease_ontology DOID:2513 Xref MGI. basal cell carcinoma ICD10CM:N45.2 MESH:D009920 NCI:C97145 SNOMEDCT_US_2020_03_01:367112009 UMLS_CUI:C0029191 Inflammation of testis Orchititis disease_ontology DOID:2518 orchitis MESH:D013733 NCI:C26890 SNOMEDCT_US_2020_03_01:236763001 UMLS_CUI:C0039584 disorder of testis testis disorder disease_ontology DOID:2519 testicular disease An alcohol-induced mental disorder involving prominent hallucinations and delusions occurring during or shortly after acute alcohol intoxication or withdrawal. ICD9CM:291.9 MESH:D011604 SNOMEDCT_US_2020_03_01:154852003 UMLS_CUI:C0033936 Alcoholic psychoses disease_ontology DOID:252 alcoholic psychosis A proteinuria that is characterized by the leaking of blood protein into the urine, swelling or edema, and degenerative lesions without inflammation. MESH:D009401 SNOMEDCT_US_2020_03_01:90708001 UMLS_CUI:C0027720 disease_ontology DOID:2527 nephrosis DOID:0000815 ICD10CM:D73 ICD9CM:289.50 MESH:D013158 NCI:C35823 SNOMEDCT_US_2020_03_01:51244008 UMLS_CUI:C0037997 Dyssplenism Spleen disease disease_ontology DOID:2529 splenic disease ICD10CM:D73.3 NCI:C35347 SNOMEDCT_US_2020_03_01:82053000 UMLS_CUI:C0272412 disease_ontology DOID:2530 splenic abscess An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. DOID:1034 DOID:2532 MESH:D019337 NCI:C27134 SNOMEDCT_US_2020_03_01:414388001 UMLS_CUI:C0376544 Hematologic malignancy Hematologic neoplasm Hematological tumors blood cancer hematopoietic and lymphoid system tumor hematopoietic cancer hematopoietic neoplasm hematopoietic tumors malignant hematopoietic neoplasm disease_ontology DOID:2531 hematologic cancer GARD:9973 ICD10CM:D73.5 MESH:D013159 SNOMEDCT_US_2020_03_01:22996003 UMLS_CUI:C0037998 Splenic infarct Splenic infarction disease_ontology DOID:2533 splenic infarction ICD10CM:G61.81 ICD9CM:357.81 MESH:D020277 NCI:C84636 SNOMEDCT_US_2020_03_01:128209004 UMLS_CUI:C0393819 disease_ontology DOID:2536 chronic inflammatory demyelinating polyneuritis ICD9CM:357 SNOMEDCT_US_2020_03_01:193172009 UMLS_CUI:C0154758 disease_ontology DOID:2537 inflammatory and toxic neuropathy GARD:6855 ICD10CM:G40.8 MESH:D018887 NCI:C84806 OMIM:245570 ORDO:98818 SNOMEDCT_US_2020_03_01:230438007 UMLS_CUI:C0282512 acquired epileptic aphasia disease_ontology DOID:2538 OMIM mapping confirmed by DO. [SN]. Landau-Kleffner syndrome An epilepsy syndrome that is located_in an area of the brain other than the temporal lobe. NCI:C7760 SNOMEDCT_US_2020_03_01:111498005 UMLS_CUI:C0270849 Extratemporal epilepsy disease_ontology DOID:2544 extratemporal epilepsy A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood. ICD10CM:D18.0 ICD9CM:228.00 MESH:D006391 NCI:C3085 SNOMEDCT_US_2020_03_01:154625006 UMLS_CUI:C0018916 disease_ontology DOID:255 hemangioma A chondromalacia that is characterized by recurrent inflammation of cartilage and other tissues throughout the body. GARD:7417 ICD10CM:M94.1 MESH:D011081 NCI:C157268 SNOMEDCT_US_2020_03_01:72275000 UMLS_CUI:C0032453 Chondromalacia, systemic disease_ontology DOID:2556 relapsing polychondritis A cartilage disease that is characterized by softening and breakdown of cartilage inside a joint. ICD10CM:M94.2 ICD9CM:733.92 MESH:D002357 SNOMEDCT_US_2020_03_01:63198006 UMLS_CUI:C0085700 disease_ontology DOID:2557 chondromalacia A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance. ICD10CM:F11.2 ICD9CM:304.00 MESH:D009293 SNOMEDCT_US_2020_03_01:75544000 UMLS_CUI:C0524662 Opioid type dependence disease_ontology DOID:2559 opiate dependence An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance. MESH:D009021 SNOMEDCT_US_2020_03_01:286934009 UMLS_CUI:C0026552 disease_ontology DOID:2560 morphine dependence A corneal dystrophy that is characterized by corneal haze, bilateral loss of vision, eventually necessitating corneal transplantation resulting from progressive punctate opacities in the cornea. ICD10CM:H18.55 ICD9CM:371.55 MESH:D003317 NCI:C34793 OMIM:217800 SNOMEDCT_US_2020_03_01:60258001 UMLS_CUI:C0024439 Fehr corneal dystrophy MACULAR DYSTROPHY, CORNEAL, 1 disease_ontology DOID:2565 macular corneal dystrophy DOID:8944 ICD10CM:H18.5 ICD9CM:371.5 MESH:D003317 NCI:C34512 NCI:C34513 SNOMEDCT_US_2020_03_01:5587004 SNOMEDCT_US_2020_03_01:77797009 UMLS_CUI:C0010035 UMLS_CUI:C0010036 disease_ontology DOID:2566 corneal dystrophy A cervix disease that is characterized by inflammation of the cervix. DOID:10110 ICD10CM:N72 ICD9CM:616.0 MESH:D002575 NCI:C26716 SNOMEDCT_US_2020_03_01:198199009 SNOMEDCT_US_2020_03_01:237081003 UMLS_CUI:C0007860 UMLS_CUI:C0007861 disease_ontology DOID:2568 cervicitis ICD9CM:362.57 MESH:D015593 SNOMEDCT_US_2020_03_01:141199000 UMLS_CUI:C0035312 disease_ontology DOID:2569 OMIM mapping confirmed by DO. [SN]. retinal drusen A histiocytosis that is characterized by clonal proliferation of Langerhans cells. DOID:10617 DOID:10618 DOID:10620 DOID:10623 DOID:10624 DOID:10625 DOID:2553 DOID:2554 DOID:9582 ICD10CM:C96.0 ICD10CM:C96.6 ICD9CM:202.5 MESH:C538636 MESH:D006646 NCI:C3107 NCI:C3160 OMIM:246400 OMIM:604856 SNOMEDCT_US_2020_03_01:154583006 SNOMEDCT_US_2020_03_01:234439008 UMLS_CUI:C0019621 UMLS_CUI:C0023381 Histiocytosis X Langerhan's cell histiocytosis Langerhans cell granulomatosis Letterer-Siwe disease Letterer-Siwe disease involving intra-abdominal lymph nodes Letterer-Siwe disease involving intrapelvic lymph nodes Letterer-Siwe disease involving intrathoracic lymph nodes Letterer-Siwe disease involving lymph nodes of axilla and upper limb Letterer-Siwe disease involving lymph nodes of head, face and neck Letterer-Siwe disease involving lymph nodes of head, face, and neck Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb Letterer-Siwe disease involving lymph nodes of multiple sites Letterer-Siwe disease involving spleen Letterer-Siwe disease of intra-abdominal lymph nodes Letterer-Siwe disease of intrapelvic lymph nodes Letterer-Siwe disease of intrathoracic lymph nodes Letterer-Siwe disease of lymph nodes of axilla and upper limb Letterer-Siwe disease of lymph nodes of axilla and/or upper limb Letterer-Siwe disease of lymph nodes of head, face and neck Letterer-Siwe disease of lymph nodes of head, face and/or neck Letterer-Siwe disease of lymph nodes of inguinal region amd/or lower limb Letterer-Siwe disease of lymph nodes of inguinal region and lower limb Letterer-Siwe disease of lymph nodes of inguinal region and/or lower limb Letterer-Siwe disease of lymph nodes of multiple sites Letterer-Siwe disease of spleen disease_ontology DOID:2571 OMIM mapping confirmed by DO. [SN]. Langerhans-cell histiocytosis A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance. ICD9CM:304.11 UMLS_CUI:C0154482 disease_ontology DOID:2575 barbiturate dependence A chondrodysplasia punctata that is characterized by disproportionately short stature primarily affecting the proximal parts of the extremities, a typical facial appearance including a broad nasal bridge, epicanthus, high-arched palate, dysplastic external ears, and micrognathia, congenital contractures, characteristic ocular involvement, dwarfism, and severe mental retardation with spasticity. GARD:13160 ICD10CM:E71.540 MESH:D018902 NCI:C85047 OMIM:PS215100 ORDO:177 SNOMEDCT_US_2020_03_01:56692003 UMLS_CUI:C0282529 Chondrodysplasia Punctata, Rhizomelic Form disease_ontology DOID:2580 OMIM mapping confirmed by DO. [SN]. rhizomelic chondrodysplasia punctata A syndrome that is characterized by abnormal calcification of the epiphyses, causing stippling in radiography. GARD:8542 ICD10CM:Q77.3 MESH:D002806 NCI:C84632 OMIM:215105 ORDO:93442 SNOMEDCT_US_2020_03_01:205486004 UMLS_CUI:C0008445 Chondrodysplasia punctata congenita disease_ontology DOID:2581 DeObs MGI. chondrodysplasia punctata MESH:D002806 GARD:363 MESH:D020642 NCI:C84526 OMIM:614097 SNOMEDCT_US_2020_03_01:190954001 UMLS_CUI:C0268419 deficiency of catalase disease_ontology DOID:2582 acatalasia A B cell deficiency that is caused by a reduction in all types of gamma globulins. DOID:618 ICD10CM:D80.1 ICD9CM:279.00 MESH:D000361 NCI:C26931 OMIM:601495 OMIM:612692 OMIM:613500 OMIM:613501 OMIM:615214 OMIM:PS601495 SNOMEDCT_US_2020_03_01:119250001 SNOMEDCT_US_2020_03_01:267512002 UMLS_CUI:C0001768 UMLS_CUI:C0086438 IGHM hypogammaglobulinemia mu heavy chain deficiency disease_ontology DOID:2583 OMIM mapping confirmed by DO. [SN]. agammaglobulinemia MESH:D000361 ICD10CM:C32.0 ICD9CM:161.0 NCI:C3544 SNOMEDCT_US_2020_03_01:187841006 UMLS_CUI:C0153483 Ca larynx - glottis malignant tumor of glottis malignant tumor of the Glottis disease_ontology DOID:2595 glottis cancer A respiratory system cancer that is located_in the larynx. GARD:6862 ICD10CM:C32 ICD9CM:161 MESH:D007822 NCI:C7484 SNOMEDCT_US_2020_03_01:93859007 UMLS_CUI:C0007107 disease_ontology DOID:2596 larynx cancer MESH:D007822 NCI:C3156 SNOMEDCT_US_2020_03_01:126692004 UMLS_CUI:C0023055 laryngeal tumor larynx neoplasm neoplasm of larynx disease_ontology DOID:2598 laryngeal benign neoplasm NCI:C4923 SNOMEDCT_US_2020_03_01:372103002 UMLS_CUI:C0740083 Glottic carcinoma carcinoma of glottis disease_ontology DOID:2599 glottis carcinoma An endocrine system disease that is located_in the pancreas. ICD10CM:K86.8 ICD9CM:577.8 SNOMEDCT_US_2020_03_01:197566002 UMLS_CUI:C0029771 disease_ontology DOID:26 pancreas disease A larynx cancer that has_material_basis_in epithelial cells. NCI:C4855 SNOMEDCT_US_2020_03_01:154480006 UMLS_CUI:C0595989 cancer of Larynx cancer of larynx carcinoma of larynx disease_ontology DOID:2600 laryngeal carcinoma A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern. GARD:6052 MESH:D002812 NCI:C53459 SNOMEDCT_US_2020_03_01:269638002 UMLS_CUI:C0936248 central Chondroma disease_ontology DOID:2602 chondroma A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue. DOID:1635 MESH:D010212 NCI:C3713 NCI:C7440 SNOMEDCT_US_2020_03_01:711329002 SNOMEDCT_US_2020_03_01:82049002 UMLS_CUI:C0030354 UMLS_CUI:C0205875 papillomatosis disease_ontology DOID:2615 papilloma A kidney cancer which is manifested in the kidney. NCI:C4527 SNOMEDCT_US_2020_03_01:254923001 UMLS_CUI:C0346256 hemangiopericytoma of kidney renal hemangiopericytoma disease_ontology DOID:262 kidney hemangiopericytoma A peripheral nervous system neoplasm that is located_in the autonomic nervous system. NCI:C5112 UMLS_CUI:C1332356 tumor of Autonomic nervous system disease_ontology DOID:2621 autonomic nervous system neoplasm DOID:3661 GARD:4214 MESH:D020288 NCI:C3698 NCI:C5800 OMIM:260500 SNOMEDCT_US_2020_03_01:18021007 UMLS_CUI:C0205770 UMLS_CUI:C1332963 childhood choroid plexus papilloma disease_ontology DOID:2626 OMIM mapping confirmed by DO. [SN]. choroid plexus papilloma A urinary system cancer that is located_in the kidney. DOID:11834 DOID:3676 ICD10CM:C64 ICD9CM:189.0 MESH:D007680 NCI:C120456 NCI:C3150 NCI:C7548 SNOMEDCT_US_2020_03_01:126880001 SNOMEDCT_US_2020_03_01:93849006 UMLS_CUI:C0022665 UMLS_CUI:C0494158 UMLS_CUI:C0740457 malignant neoplasm of kidney except pelvis malignant tumour of kidney renal cancer disease_ontology DOID:263 kidney cancer An adenoma that forms a cyst. MESH:D003537 NCI:C2972 SNOMEDCT_US_2020_03_01:189680006 UMLS_CUI:C0010633 Cystadenoma Cystoma disease_ontology DOID:2634 cystadenoma An ovarian benign neoplasm that has_material_basis_in the surface epithelium of the ovary. GARD:9397 MESH:D001948 NCI:C39954 SNOMEDCT_US_2020_03_01:74739000 UMLS_CUI:C0006160 benign ovarian Brenner tumor benign ovarian Brenner tumour ovarian Brenner tumour disease_ontology DOID:2636 ovarian Brenner tumor A breast fibroadenoma that is characterized by stromal proliferation around epithelial structures. NCI:C4272 SNOMEDCT_US_2020_03_01:41382006 UMLS_CUI:C0334497 Pericanalicular Fibroadenoma of breast Pericanalicular fibroadenoma disease_ontology DOID:2639 breast pericanalicular fibroadenoma A soft tissue cancer that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries. DOID:5372 GARD:2627 MESH:D006393 NCI:C3087 SNOMEDCT_US_2020_03_01:134335004 UMLS_CUI:C0018922 Haemangiopericytic meningioma hemangiopericytoma, malignant malignant hemangiopericytoma disease_ontology DOID:264 hemangiopericytoma An ovarian germ cell monodermal and highly specialized teratoma that is composed either exclusively or predominantly of thyroid tissue. MESH:D013330 NCI:C7468 SNOMEDCT_US_2020_03_01:24327009 UMLS_CUI:C0038478 Struma ovarii disease_ontology DOID:2640 struma ovarii A monodermal teratoma that has_material_basis in germ cells that are highly specialized and is located_in the ovary. NCI:C8113 UMLS_CUI:C0280134 Ovarian Monodermal and Highly Specialized teratoma disease_ontology DOID:2641 ovarian germ cell monodermal and highly specialized teratoma MESH:D054973 NCI:C38150 SNOMEDCT_US_2020_03_01:388601000 UMLS_CUI:C1300127 PEComa neoplasm with Perivascular epithelioid cell differentiation disease_ontology DOID:2643 perivascular epithelioid cell tumor A cell type benign neoplasm that has_material_basis_in mesothelium. DOID:2644 ICD10CM:C45 MESH:D008654 NCI:C3234 SNOMEDCT_US_2020_03_01:154491004 UMLS_CUI:C0025500 benign tumor of Mesothelium disease_ontology DOID:2645 benign mesothelioma NCI:C6581 SNOMEDCT_US_2020_03_01:404086000 UMLS_CUI:C1266175 disease_ontology DOID:2647 parachordoma DOID:7387 NCI:C4174 SNOMEDCT_US_2020_03_01:78424008 UMLS_CUI:C1368816 Sebaceous adenoma adenoma of the Sebaceous gland skin appendage sebaceous adenoma disease_ontology DOID:2648 sebaceous adenoma A connective tissue benign neoplasm that derives_from chondroblasts and begins in cartilage at the ends of long bones (thighbone, shinbone, humerus) close to the joints. GARD:6047 MESH:D002804 NCI:C2945 SNOMEDCT_US_2020_03_01:9001003 UMLS_CUI:C0008441 Chondroblastoma of bone disease_ontology DOID:2649 chondroblastoma A cystic teratoma that is composed exclusively of mature tissues derived from two or three germ layers (ectoderm, mesoderm and endoderm). ICD10CM:K09.8 MESH:D003884 NCI:C9011 SNOMEDCT_US_2020_03_01:189117002 UMLS_CUI:C0011649 Dermoid choristoma Dermoid tumour Mature cystic teratoma cystic dermoid choristoma teratoma, benign disease_ontology DOID:2658 dermoid cyst A benign teratoma that is characterized by the presence of cysts or cystic spaces. NCI:C9014 SNOMEDCT_US_2020_03_01:42717009 UMLS_CUI:C1368903 disease_ontology DOID:2660 cystic teratoma A sweat gland benign neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland. MESH:D009208 NCI:C40392 SNOMEDCT_US_2020_03_01:69291002 UMLS_CUI:C0027070 Myoepithelial adenoma Myoepithelial neoplasm benign myoepithelioma disease_ontology DOID:2661 myoepithelioma MESH:D013544 NCI:C3398 SNOMEDCT_US_2020_03_01:126490003 UMLS_CUI:C0038987 Sweat gland tumor neoplasm of sweat gland tumor of the Sweat gland disease_ontology DOID:2664 sweat gland benign neoplasm MESH:D008637 NCI:C3233 SNOMEDCT_US_2020_03_01:44524009 UMLS_CUI:C0025464 disease_ontology DOID:2668 mesenchymoma A carcinoma that derives_from transitional epithelial cells. DOID:3995 GARD:7794 MESH:D002295 NCI:C2930 NCI:C6783 SNOMEDCT_US_2020_03_01:118287003 SNOMEDCT_US_2020_03_01:27090000 UMLS_CUI:C0007138 UMLS_CUI:C0334265 transitional carcinoma transitional cell tumor urothelial cell carcinoma disease_ontology transitional cell neoplasm DOID:2671 transitional cell carcinoma A nephroma that is characterized as a localized, well-circumscribed multilocular tumor lined by hobnail epithelium. NCI:C7504 multilocular cystic nephroma, mixed epithelial stromal tumour and renal epithelial stromal tumour disease_ontology DOID:2673 adult cystic nephroma GARD:10640 NCI:C9505 SNOMEDCT_US_2020_03_01:87211000119104 UMLS_CUI:C1266177 Dysembryoplastic Neuroepithelial neoplasm Dysembryoplastic neuroepithelial tumor Dysembryoplastic neuroepithelial tumour dysembryoplastic neuroepithelial tumour disease_ontology DOID:2679 dysembryoplastic neuroepithelial tumor A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands. MESH:D000232 SNOMEDCT_US_2020_03_01:189823009 UMLS_CUI:C0001422 disease_ontology DOID:2683 adenofibroma MESH:D000232 NCI:C6582 SNOMEDCT_US_2020_03_01:404076001 UMLS_CUI:C1266128 Ossifying Fibromyxoma Ossifying fibromyxoid tumor Ossifying fibromyxoid tumour ossifying fibromyxoid tumour disease_ontology DOID:2685 ossifying fibromyxoid tumor A lymphatic system cancer that has_material_basis_in endothelial cells located_in lymphatic vessels. DOID:2686 MESH:C537491 MESH:D008204 NCI:C3205 NCI:C4490 SNOMEDCT_US_2020_03_01:403986008 SNOMEDCT_US_2020_03_01:62497000 UMLS_CUI:C0024224 UMLS_CUI:C0346082 Lymphangiosarcoma of Stewart and Treves Stewart-Treves syndrome malignant Lymphangioendothelioma skin lymphangiosarcoma disease_ontology DOID:2689 lymphangiosarcoma A muscle benign neoplasm that is characterized as benign hyperplastic lesions of uterine smooth muscle cells. ICD10CM:D21 MESH:D009214 NCI:C4882 SNOMEDCT_US_2020_03_01:66357004 UMLS_CUI:C0027086 benign neoplasm of the Muscle disease_ontology DOID:2691 myoma A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located_in ovary or testicle. DOID:0050616 MESH:D007984 NCI:C3188 NCI:C4213 SNOMEDCT_US_2020_03_01:45002009 SNOMEDCT_US_2020_03_01:77870005 UMLS_CUI:C0023601 UMLS_CUI:C0334410 Leydig cell neoplasm disease_ontology DOID:2696 Leydig cell tumor NCI:C8383 SNOMEDCT_US_2020_03_01:41627005 UMLS_CUI:C0334684 renal cell adenoma disease_ontology DOID:2697 renal adenoma NCI:C39812 SNOMEDCT_US_2020_03_01:128760004 UMLS_CUI:C1266141 Metanephric adenofibroma disease_ontology DOID:2698 nephrogenic adenofibroma A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver. NCI:C4437 SNOMEDCT_US_2020_03_01:254601002 UMLS_CUI:C0345906 hepatic sarcoma disease_ontology DOID:270 liver sarcoma DOID:2665 MESH:D000070779 NCI:C3829 NCI:C6532 SNOMEDCT_US_2020_03_01:5178002 SNOMEDCT_US_2020_03_01:71508003 UMLS_CUI:C0221289 UMLS_CUI:C0588125 Synovioma, benign benign synovioma benign tumor of Synovium localized Giant cell tumor of Tenosynovium disease_ontology DOID:2701 nodular tenosynovitis GARD:7396 ICD10CM:M12.2 MESH:D013586 NCI:C3401 SNOMEDCT_US_2020_03_01:202903009 UMLS_CUI:C0039106 Diffuse Giant cell tumor of Tenosynovium villous tenosynovitis disease_ontology DOID:2702 pigmented villonodular synovitis A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling. GARD:7722 MESH:D013585 NCI:C50766 SNOMEDCT_US_2020_03_01:268092005 UMLS_CUI:C0039103 disease_ontology DOID:2703 synovitis NCI:C6531 UMLS_CUI:C1334624 malignant tumor of Synovium disease_ontology DOID:2706 synovium cancer An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building. MESH:D018877 SNOMEDCT_US_2020_03_01:19076009 UMLS_CUI:C0037050 disease_ontology DOID:2710 sick building syndrome ICD10CM:N47.1 MESH:D010688 NCI:C26852 SNOMEDCT_US_2020_03_01:449826002 UMLS_CUI:C0031538 Tight foreskin Tight frenulum disease_ontology DOID:2712 phimosis A syndrome characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability. MESH:D001816 NCI:C2903 OMIM:210900 ORDO:125 SNOMEDCT_US_2020_03_01:4434006 UMLS_CUI:C0005859 Bloom-Torre-Machacek syndrome Congenital Telangiectatic Erythema syndrome disease_ontology DOID:2717 OMIM mapping confirmed by DO. [SN]. Bloom syndrome A pneumothorax that is characterized by having air in the chest cavity and blood in the chest cavity. ICD10CM:J94.2 MESH:D006468 SNOMEDCT_US_2020_03_01:16632002 UMLS_CUI:C0019077 haemopneumothorax disease_ontology DOID:2718 hemopneumothorax A vascular disease that is located_in the liver. NCI:C35442 SNOMEDCT_US_2020_03_01:235878005 UMLS_CUI:C0400923 vascular disorder of liver disease_ontology DOID:272 hepatic vascular disease A dermatitis that selectively affects the hands and feet. GARD:5722 MESH:D000169 NCI:C84532 SNOMEDCT_US_2020_03_01:8197001 UMLS_CUI:C0001197 disease_ontology DOID:2722 acrodermatitis MESH:D000169 A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin. DOID:8614 DOID:8917 ICD10CM:L30.9 MESH:D003872 NCI:C2983 SNOMEDCT_US_2020_03_01:238538009 UMLS_CUI:C0011603 eczema skin inflammation disease_ontology DOID:2723 dermatitis ICD10CM:Q82.5 MESH:D018324 NCI:C7457 SNOMEDCT_US_2020_03_01:56975005 UMLS_CUI:C0206733 Capillary hemangioma Congenital vascular hamartoma Congenital vascular naevus Infantile hemangioma Juvenile hemangioma Strawberry haemangioma Strawberry nevus Strawberry nevus of skin cellular hemangioma of Infancy disease_ontology DOID:2725 capillary hemangioma A skin disease characterized by cutaneous pigmentation, premature graying, dystrophy of the nails, leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts, often thrombocytopenia, anemia, testicular atrophy in the male carriers and predisposition to cancer. GARD:10905 MESH:D019871 NCI:C111802 OMIM:PS127550 ORDO:1775 SNOMEDCT_US_2020_03_01:74911008 UMLS_CUI:C0265965 disease_ontology DOID:2729 Xref MGI. OMIM mapping by NeuroDevNet. [LS]. dyskeratosis congenita A vesiculobullous skin disease that is characterized by formation of blisters with only minor skin trauma, which can cause widespread wounds, dehydration, electrolyte abnormalities, and severe infection, frequently develops_from mutations in connective tissue elements, including genes encoding keratin, collagen, and laminin. GARD:6359 ICD10CM:Q81 MESH:D004820 NCI:C67383 SNOMEDCT_US_2020_03_01:205580008 UMLS_CUI:C0014527 Epidermolysis bullosa acantholysis bullosa disease_ontology DOID:2730 epidermolysis bullosa A skin disease that is characterized by fluid filled blisters. MESH:D012872 UMLS_CUI:C0037275 disease_ontology DOID:2731 vesiculobullous skin disease GARD:4392 ICD10CM:Q82.8 MESH:D011038 NCI:C3335 OMIM:268400 SNOMEDCT_US_2020_03_01:205572001 UMLS_CUI:C0032339 Congenital poikiloderma RTS disease_ontology DOID:2732 OMIM mapping confirmed by DO. [SN]. Rothmund-Thomson syndrome MESH:D011038 ICD10CM:L90 NCI:C35163 SNOMEDCT_US_2020_03_01:16343004 UMLS_CUI:C0151514 Atrophoderma Atrophy - skin atrophic condition of skin disease_ontology DOID:2733 skin atrophy ICD10CM:E50.8 MESH:D007644 NCI:C84665 OMIM:124200 SNOMEDCT_US_2020_03_01:157017000 UMLS_CUI:C0022595 DARIER-WHITE DISEASE Darier's disease Keratosis follicularis disease_ontology DOID:2734 OMIM mapping confirmed by DO. [SN]. keratosis follicularis A bone disease characterized by short stature, coarse and dysmorphic facies, bowing of the long bones, and vertebral anomalies that has_material_basis_in heterozygous mutation in NOTCH2 on chromosome 1p12. DOID:2735 GARD:508 MESH:D030981 MESH:D031845 NCI:C35545 NCI:C84745 OMIM:102500 SNOMEDCT_US_2020_03_01:63122002 UMLS_CUI:C0917715 UMLS_CUI:C0917990 Cheney syndrome HJCYS SFPKS acroosteolysis with osteoporosis and changes in skull and mandible arthrodentoosteodysplasia serpentine fibula-polycystic kidney syndrome disease_ontology DOID:2736 OMIM mapping confirmed by DO. [SN]. Hajdu-Cheney syndrome A connective tissue disease that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system. GARD:9643 MESH:D011561 NCI:C85036 OMIM:177850 OMIM:264800 ORDO:758 SNOMEDCT_US_2020_03_01:7109007 UMLS_CUI:C0033847 Gronblad-Strandberg syndrome disease_ontology DOID:2738 Xref MGI. OMIM mapping confirmed by DO. [SN]. pseudoxanthoma elasticum A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity. GARD:6507 ICD10CM:E80.4 MESH:D005878 NCI:C84729 OMIM:143500 SNOMEDCT_US_2020_03_01:27503000 UMLS_CUI:C0017551 Constitutional hyperbilirubinemia Gilbert's disease Gilbert's syndrome Gilbert-Meulengracht syndrome hereditary nonhemolytic jaundice disease_ontology DOID:2739 OMIM mapping confirmed by DO. [SN]. Gilbert syndrome An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism. DOID:2740 MESH:D006932 MESH:D006933 NCI:C84761 SNOMEDCT_US_2020_03_01:154770008 UMLS_CUI:C0020433 UMLS_CUI:C0020435 hereditary hyperbilirubinemia hyperbilirubinemia disease_ontology hyperbilirubinaemia DOID:2741 bilirubin metabolic disorder A sensory system disease that is characterized by auditory dysfunction located_in the auditory system. DOID:1490 DOID:2011 ICD10CM:H93.9 ICD9CM:388.9 MESH:D004427 NCI:C26757 SNOMEDCT_US_2020_03_01:194193002 UMLS_CUI:C0013447 ear and mastoid disease disease_ontology DOID:2742 auditory system disease ICD10CM:N12 MESH:D011702 NCI:C34964 SNOMEDCT_US_2020_03_01:27174002 UMLS_CUI:C0034183 disease_ontology DOID:2744 pyelitis A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity. ICD10CM:F60.81 ICD9CM:301.81 MESH:D010554 NCI:C92635 SNOMEDCT_US_2020_03_01:80711002 UMLS_CUI:C0027402 disease_ontology DOID:2745 narcissistic personality disorder GARD:6528 ICD10CM:E74.04 MESH:D006012 NCI:C84738 OMIM:232600 SNOMEDCT_US_2020_03_01:55912009 UMLS_CUI:C0017924 Glycogen storage disease, type V McArdle's disease glycogen storage disease type V myophosphorylase deficiency disease_ontology DOID:2746 OMIM mapping confirmed by DO. [SN]. glycogen storage disease V A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. ICD10CM:E74.0 ICD9CM:271.0 MESH:D006008 NCI:C61272 SNOMEDCT_US_2020_03_01:267498002 UMLS_CUI:C0017919 glycogenosis glycogenoses disease_ontology DOID:2747 glycogen storage disease GARD:2520 ICD10CM:E74.09 MESH:D006011 NCI:C84737 OMIM:232500 SNOMEDCT_US_2020_03_01:11179002 UMLS_CUI:C0017923 Amylopectinosis Branching-transferase deficiency glycogenosis Glycogen storage disease, type IV brancher deficiency glycogenosis deficiency of 1,4-alpha-glucan branching enzyme disease_ontology DOID:2750 OMIM mapping confirmed by DO. [SN]. glycogen storage disease IV A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to an accumulation of glycogen in the lysosome. GARD:5714 ICD10CM:E74.02 MESH:D006009 NCI:C84734 OMIM:232300 SNOMEDCT_US_2020_03_01:237967002 UMLS_CUI:C0017921 Generalized glycogenosis Glycogen storage disease, type II Glycogenosis, type 2 Lysosomal alpha-1,4-glucosidase deficiency Pompe's disease acid maltase deficiency deficiency of glucoamylase deficiency of maltase glycogen storage disease type II disease_ontology DOID:2752 OMIM mapping confirmed by DO. [SN]. glycogen storage disease II A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons. GARD:7123 MESH:D015270 NCI:C36197 SNOMEDCT_US_2020_03_01:14009004 UMLS_CUI:C0026916 Infection due to Mycobacterium intracellulare MAC disease Mycobacterium Avium Infection Mycobacterium avium Complex disease_ontology DOID:2755 Mycobacterium avium complex disease MESH:D015270 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity. ICD10CM:F95 ICD9CM:307.20 MESH:D013981 SNOMEDCT_US_2020_03_01:155005001 UMLS_CUI:C0040188 disease_ontology DOID:2769 tic disorder A contact dermatitis that is characterized by a cutaneous inflammatory reaction to repeated contact with an irritant substance, friction, liquid, or adverse temperature that interacts with the skin and often has_symptom erythema, edema, scaling, pain, pruritis, or burning sensation. ICD10CM:L24.9 MESH:D017453 NCI:C27151 SNOMEDCT_US_2020_03_01:110979008 UMLS_CUI:C0162823 Irritant Contact Dermatitis Irritant contact dermatitis primary irritant dermatitis disease_ontology DOID:2772 irritant dermatitis ICD10CM:L25.9 MESH:D003877 NCI:C26743 SNOMEDCT_US_2020_03_01:156338009 UMLS_CUI:C0011616 Contact dermatitis Contact dermatitis/eczema Contact eczema Dermatitis, venenata dermatitis venenata disease_ontology DOID:2773 contact dermatitis A bone cancer that is located_in almost exclusively in the long bones. MESH:D050398 NCI:C7644 ORDO:55881 UMLS_CUI:C1367554 disease_ontology DOID:2776 adamantinoma MESH:D050398 A lung cancer that is located_in the lung and that arises from transformed cells of mesenchymal origin. NCI:C4860 UMLS_CUI:C0598790 pulmonary sarcoma disease_ontology DOID:2784 lung sarcoma A cerebellar disease that is characterized by hypoplasia and upward rotation of the cerebellar vermis and cystic dilation of the fourth ventricle. GARD:6242 ICD10CM:Q03.1 MESH:D003616 NCI:C75012 OMIM:220200 SNOMEDCT_US_2020_03_01:14447001 UMLS_CUI:C0010964 Atresia of foramina of Magendie and Luschka disease_ontology DOID:2785 OMIM mapping confirmed by DO. [SN]. Dandy-Walker syndrome A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. MESH:D002526 SNOMEDCT_US_2020_03_01:267691001 UMLS_CUI:C0007760 disease_ontology DOID:2786 cerebellar disease A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes. DOID:0060003 DOID:10553 DOID:3734 DOID:3804 DOID:947 ICD10CM:B64 MESH:D011528 NCI:C34953 SNOMEDCT_US_2020_03_01:95896000 UMLS_CUI:C0033740 mastigophora infectious disease sarcomastigophora infectious disease disease_ontology DOID:2789 parasitic protozoa infectious disease A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching. DOID:13048 ICD10CM:B76.1 MESH:D009332 NCI:C34838 SNOMEDCT_US_2020_03_01:36667009 UMLS_CUI:C0027528 disease_ontology DOID:2790 necatoriasis A pneumonia located_in the lung parenchyma of unknown cause. ICD10CM:J84.114 MESH:D000080203 SNOMEDCT_US_2020_03_01:129459004 UMLS_CUI:C0085786 Diffuse idiopathic pulmonary fibrosis Idiopathic fibrosing alveolitis disease_ontology IPF DOID:2797 idiopathic interstitial pneumonia A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults. GARD:9551 MESH:D001989 NCI:C62580 SNOMEDCT_US_2020_03_01:40100001 UMLS_CUI:C0006272 Bronchiolitis exudativa Bronchiolitis fibrosa obliterans Obliterative bronchiolitis disease_ontology DOID:2799 bronchiolitis obliterans A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. ICD10CM:E34.9 ICD9CM:259.9 MESH:D004700 NCI:C3009 SNOMEDCT_US_2020_03_01:67432001 UMLS_CUI:C0014130 disease_ontology DOID:28 endocrine system disease ICD10CM:C72.50 ICD9CM:192.0 MESH:D003390 NCI:C3571 SNOMEDCT_US_2020_03_01:188311003 UMLS_CUI:C0153644 malignant neoplasm of cranial nerve malignant neoplasm of cranial nerves malignant tumor of cranial nerve malignant tumor of the Cranial nerve disease_ontology DOID:2815 cranial nerve malignant neoplasm MESH:D009668 SNOMEDCT_US_2020_03_01:89488007 UMLS_CUI:C0028432 disorder of the nose nasal disorder disease_ontology DOID:2825 nose disease DOID:2827 MESH:D042101 NCI:C35578 SNOMEDCT_US_2020_03_01:19968009 UMLS_CUI:C0267841 acute acalculous cholecystitis acute cholecystitis without calculus cholecystitis without calculus disease_ontology DOID:2828 acalculous cholecystitis MESH:D042101 A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 EFO:0000270 GARD:10246 ICD10CM:J45 ICD9CM:493 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 SNOMEDCT_US_2020_03_01:187687003 UMLS_CUI:C0004096 Exercise induced asthma bronchial hyperreactivity chronic obstructive asthma chronic obstructive asthma with acute exacerbation chronic obstructive asthma with status asthmaticus exercise-induced asthma disease_ontology DOID:2841 Xref MGI. asthma MESH:D001249 An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles). DOID:4069 GARD:6922 ICD10CM:I45.81 ICD9CM:426.82 MESH:D008133 NCI:C34786 OMIM:PS192500 ORDO:101016 ORDO:768 SNOMEDCT_US_2020_03_01:20852007 SNOMEDCT_US_2020_03_01:9651007 UMLS_CUI:C0023976 UMLS_CUI:C0035828 LQT Romano-Ward syndrome long Q-T syndrome disease_ontology DOID:2843 OMIM mapping confirmed by DO. [SN]. long QT syndrome MESH:D003866 NCI:C34812 SNOMEDCT_US_2020_03_01:35489007 UMLS_CUI:C0025193 disease_ontology DOID:2848 melancholia A chronic lymphocytic leukemia that is characterized by over production of B cells (lymphocytes) by the bone marrow where the B cells appear hairy under a microscope. GARD:6560 ICD10CM:C91.4 ICD9CM:202.4 MESH:D007943 NCI:C7402 SNOMEDCT_US_2020_03_01:118613001 UMLS_CUI:C0023443 disease_ontology DOID:285 hairy cell leukemia A thyroid gland disease that is characterized by elevated thyroxine levels in the blood. MESH:D006981 NCI:C131850 UMLS_CUI:C0020551 disease_ontology DOID:2855 hyperthyroxinemia MESH:D006981 ICD10CM:E07.81 ICD9CM:790.94 MESH:D005067 NCI:C113170 SNOMEDCT_US_2020_03_01:237542005 UMLS_CUI:C0015190 Euthyroid sick syndrome Sick-euthyroid syndrome disease_ontology DOID:2856 euthyroid sick syndrome GARD:12455 ICD10CM:D58.2 MESH:D006453 NCI:C3092 SNOMEDCT_US_2020_03_01:154794008 UMLS_CUI:C0019045 hemoglobinopathies disease_ontology DOID:2860 hemoglobinopathy A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH). GARD:6520 MESH:D005955 NCI:C98933 SNOMEDCT_US_2020_03_01:124134002 UMLS_CUI:C2939465 Glucose-6-phosphate dehydrogenase deficiency deficiency of G-6PD disease_ontology DOID:2862 glucosephosphate dehydrogenase deficiency An endometrial carcinoma that derives_from epithelial cells of glandular origin. DOID:5827 DOID:6650 NCI:C6287 NCI:C6290 NCI:C7359 SNOMEDCT_US_2020_03_01:123845008 SNOMEDCT_US_2020_03_01:762458004 UMLS_CUI:C0279763 UMLS_CUI:C1153706 UMLS_CUI:C1336905 adenocarcinoma of endometrium adenocarcinoma of the Endometrium adenocarcinoma of uterus endometrial adenoacanthoma endometrial endometrioid adenocarcinoma endometrial endometrioid adenocarcinoma with squamous differentiation endometrioid adenoma or carcinoma endometrioid adenomas and carcinomas endometrioid carcinoma of Endometrium disease_ontology DOID:2870 endometrial adenocarcinoma A endometrial cancer that is located_in the tissue lining the uterus. DOID:3000 MESH:D016889 MESH:D018269 NCI:C3769 NCI:C7558 SNOMEDCT_US_2020_03_01:30289006 SNOMEDCT_US_2020_03_01:93781006 UMLS_CUI:C0206687 UMLS_CUI:C0476089 carcinoma of the Endometrium endometrioid carcinoma endometrioid carcinoma of female Reproductive system disease_ontology DOID:2871 OMIM mapping confirmed by DO. [SN]. endometrial carcinoma A laryngeal carcinoma that has_material_basis_in squamous cells. NCI:C4044 SNOMEDCT_US_2020_03_01:707358000 UMLS_CUI:C0280324 Epidermoid carcinoma of the Larynx squamous cell carcinoma of larynx disease_ontology DOID:2876 laryngeal squamous cell carcinoma A uterine disease that is characterized by the presence of endometrial tissue grows outside of the endometrium, such as into the myometrium. ICD10CM:N80.0 ICD9CM:617.0 MESH:D062788 NCI:C6996 OMIM:600458 SNOMEDCT_US_2020_03_01:76376003 UMLS_CUI:C0341858 Endometriosis interna Endometriosis of myometrium Endometriosis, myometrium adenomyosis uterine Adenomyosis disease_ontology DOID:288 OMIM mapping confirmed by DO. [SN]. endometriosis of uterus A male reproductive organ benign neoplasm that derives_from glandular epithelial cells and that is located_in the prostate. MESH:D011470 NCI:C4795 SNOMEDCT_US_2020_03_01:21173002 UMLS_CUI:C0520477 adenoma - prostate adenoma of prostate benign adenoma of prostate prostate adenoma disease_ontology DOID:2883 prostatic adenoma MESH:D012181 UMLS_CUI:C0035352 disease_ontology DOID:2889 retrocochlear disease A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body. EFO:0001065 ICD10CM:N80 ICD9CM:617 MESH:D004715 NCI:C3014 SNOMEDCT_US_2020_03_01:11871002 UMLS_CUI:C0014175 disease_ontology DOID:289 endometriosis An endocrine organ benign neoplasm that is located_in the thyroid and derives_from glandular epithelial cells. MESH:D013964 NCI:C3502 SNOMEDCT_US_2020_03_01:189174004 UMLS_CUI:C0151468 adenoma of thyroid gland disease_ontology DOID:2891 thyroid adenoma A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C9039 SNOMEDCT_US_2020_03_01:285432005 UMLS_CUI:C0302592 cancer of cervix carcinoma cervix uteri carcinoma of cervix carcinoma of the Cervix Uteri disease_ontology DOID:2893 OMIM mapping confirmed by DO. [SN]. cervix carcinoma A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch. GARD:6540 ICD10CM:Q87.0 MESH:D006053 NCI:C84740 OMIM:164210 ORDO:374 SNOMEDCT_US_2020_03_01:46567003 UMLS_CUI:C0265240 Facio-auriculo-vertebral spectrum First AND second branchial arch syndrome First arch syndrome HEMIFACIAL MICROSOMIA OAV (oculoauriculovertebral) dysplasia Otomandibular dysostosis disease_ontology DOID:2907 OMIM mapping confirmed by DO. [SN]. Goldenhar syndrome A syndrome that is characterized by bilateral and symmetric downslanting palpebral fissures, malar hypoplasia, micrognathia, and external ear abnormalities. GARD:9124 ICD10CM:Q75.4 MESH:D008342 NCI:C75018 OMIM:PS154500 SNOMEDCT_US_2020_03_01:205416009 UMLS_CUI:C0242387 Franceschetti syndrome Mandibulofacial dysostosis mandibulofacial dysostosis disease_ontology DOID:2908 OMIM mapping confirmed by DO. [SN]. Treacher Collins syndrome MESH:D008342 DOID:2912 ICD10CM:K85 ICD9CM:577.0 MESH:D010195 NCI:C95437 SNOMEDCT_US_2020_03_01:39726008 UMLS_CUI:C0001339 PANCREATITIS NECROTIZING acute necrotizing pancreatitis disease_ontology DOID:2913 acute pancreatitis A disease of anatomical entity that is located_in the immune system. EFO:0000540 ICD10CM:D89.9 ICD9CM:279.9 SNOMEDCT_US_2020_03_01:154782004 UMLS_CUI:C0041806 disease_ontology DOID:2914 immune system disease A hypersensitivity reaction disease that is characterized by a cell-mediated response to antigens, where Th1 helper T cells react with antigens on antigen-presenting cells and cause a delayed type immune response. ICD10CM:C88.9 MESH:D007160 SNOMEDCT_US_2020_03_01:127071007 UMLS_CUI:C0021070 disease_ontology immunoproliferative disease DOID:2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures. GARD:6217 ICD10CM:D89.1 MESH:D003449 NCI:C26736 SNOMEDCT_US_2020_03_01:30911005 UMLS_CUI:C0010403 CRYOGLOBULINEMIA Cryoimmunoglobulinaemia disease_ontology DOID:2917 cryoglobulinemia NCI:C5102 SNOMEDCT_US_2020_03_01:416510003 UMLS_CUI:C1334361 lacrimal system neoplasm neoplasm of lacrimal system tumor of the lacrimal system disease_ontology DOID:292 lacrimal system cancer GARD:11982 MESH:D015432 NCI:C34644 OMIM:305800 SNOMEDCT_US_2020_03_01:80321008 UMLS_CUI:C0017662 Lobular glomerulonephritis chronic glomerulonephritis, lobular disease_ontology DOID:2920 membranoproliferative glomerulonephritis A nephritis that causes inflammation of the glomeruli located_in kidney. GARD:6516 ICD10CM:N08 MESH:D005921 NCI:C26784 SNOMEDCT_US_2020_03_01:36171008 UMLS_CUI:C0017658 disease_ontology DOID:2921 glomerulonephritis A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. ICD10CM:Q87.2 MESH:D007715 NCI:C84801 OMIM:149000 SNOMEDCT_US_2020_03_01:59078009 UMLS_CUI:C0022739 Haemangiectatic hypertrophy Klippel-Trenaunay-Weber syndrome angioosteohypertrophy syndrome disease_ontology DOID:2926 OMIM mapping confirmed by DO. [SN]. Klippel-Trenaunay syndrome A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds. MESH:D009521 NCI:C34849 SNOMEDCT_US_2020_03_01:258300000 UMLS_CUI:C0027983 Newcastle's disease Pseudo-fowlpest disease_ontology DOID:2929 Newcastle disease A syndrome characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy; it is that has_material_basis_in mutations in the CHS1 gene. GARD:6035 ICD10CM:E70.330 MESH:D002609 NCI:C2941 OMIM:214500 ORDO:167 SNOMEDCT_US_2020_03_01:111396008 UMLS_CUI:C0007965 CHS Chediak - Steinbrinck anomaly disease_ontology DOID:2935 OMIM mapping confirmed by DO. [SN]. Chediak-Higashi syndrome DOID:291 ICD9CM:190.2 NCI:C3563 NCI:C4360 SNOMEDCT_US_2020_03_01:127004000 SNOMEDCT_US_2020_03_01:188271007 UMLS_CUI:C0153627 UMLS_CUI:C0339124 malignant neoplasm of lacrimal gland malignant tumour of lacrimal gland neoplasm of lacrimal gland tumor of the lacrimal gland disease_ontology DOID:294 lacrimal gland cancer A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen. MESH:D001988 NCI:C39658 SNOMEDCT_US_2020_03_01:4120002 UMLS_CUI:C0006271 disease_ontology DOID:2942 bronchiolitis A Coronavirus infection that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia. GARD:9237 ICD10CM:J12.81 ICD9CM:079.82 MESH:D045169 NCI:C85064 SNOMEDCT_US_2020_03_01:398447004 UMLS_CUI:C1175175 SARS SARS-CoV infection disease_ontology DOID:2945 severe acute respiratory syndrome ICD10CM:T75.3 ICD9CM:994.6 MESH:D009041 NCI:C34824 OMIM:158280 SNOMEDCT_US_2020_03_01:37031009 UMLS_CUI:C0026603 Travel Sickness disease_ontology DOID:2951 OMIM mapping confirmed by DO. [SN]. motion sickness ICD10CM:H83.9 MESH:D007759 NCI:C128369 NCI:C27166 SNOMEDCT_US_2020_03_01:194690003 SNOMEDCT_US_2020_03_01:20425006 UMLS_CUI:C0022890 UMLS_CUI:C0494559 labyrinthine disease disease_ontology DOID:2952 inner ear disease A B cell deficiency that is characterized by relative predominance of certain immunoglobulin subtypes and deficiencies of others. NCI:C27579 UMLS_CUI:C1334069 disease_ontology DOID:2959 hyperimmunoglobulin syndrome A trichothiodystrophy characterized by skin that is extremely sensitive to ultraviolet (UV) rays from sunlight. MESH:D054463 NCI:C4924 OMIM:PS601675 SNOMEDCT_US_2020_03_01:723551003 IBIDS syndrome TTD-P Tay syndrome sulfur-deficient brittle hair syndrome trichothiodystrophy with congenital ichthyosis disease_ontology DOID:2960 OMIM mapping confirmed by DO. [SN]. photosensitive trichothiodystrophy A syndrome that has_material_basis_in rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. GARD:6122 ICD10CM:Q87.19 MESH:D003057 NCI:C9460 OMIM:133540 OMIM:216400 ORDO:191 ORDO:90321 ORDO:90322 ORDO:90324 SNOMEDCT_US_2020_03_01:205832003 UMLS_CUI:C0009207 Neill-Dingwall syndrome disease_ontology Cockayne's syndrome DOID:2962 Xref MGI. OMIM mapping confirmed by DO. [SN]. Cockayne syndrome ICD10CM:M71.9 MESH:D002062 NCI:C94407 SNOMEDCT_US_2020_03_01:156677003 UMLS_CUI:C0006444 disease_ontology DOID:2965 bursitis NCI:C4397 SNOMEDCT_US_2020_03_01:17264009 UMLS_CUI:C0344460 carcinoma ex pleomorphic adenoma carcinoma in pleomorphic adenoma disease_ontology DOID:297 pleomorphic adenoma carcinoma MESH:D052177 UMLS_CUI:C0022679 renal Cyst disease_ontology DOID:2975 cystic kidney disease A carbohydrate metabolic disorder characterized by impaired glyoxylate metabolism resulting in accumulation of oxalate throughout the body typically manifesting as kidney and bladder stones. DOID:2979 ICD10CM:E72.53 ICD10CM:R82.992 MESH:D006959 MESH:D006960 NCI:C123158 OMIM:PS259900 ORDO:416 SNOMEDCT_US_2020_03_01:190766003 SNOMEDCT_US_2020_03_01:367621000119107 UMLS_CUI:C0020500 UMLS_CUI:C0020501 disease_ontology DOID:2977 OMIM mapping confirmed by DO. [SN]. primary hyperoxaluria An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates. DOID:9434 MESH:D002239 UMLS_CUI:C0007001 disorder of carbohydrate transport and metabolism inborn carbohydrate metabolism disorder inborn errors of carbohydrate metabolism disease_ontology DOID:2978 carbohydrate metabolic disorder MESH:D010501 SNOMEDCT_US_2020_03_01:111404004 UMLS_CUI:C0031065 disease_ontology DOID:2982 perinephritis MESH:D001002 NCI:C114699 SNOMEDCT_US_2020_03_01:139460001 UMLS_CUI:C0003460 Suppression of urinary secretion disease_ontology DOID:2983 anuria A glomerulonephritis characterized by build up of IgA antibody in the glomerulus. EFO:0004194 GARD:863 MESH:D005922 NCI:C34643 OMIM:161950 SNOMEDCT_US_2020_03_01:236407003 UMLS_CUI:C0017661 Berger's IgA or IgG nephropathy Focal Glomerulonephritis IGA glomerulonephritis IgA nephropathy primary IgA nephropathy segmental glomerulonephritis disease_ontology DOID:2986 OMIM mapping confirmed by DO. [SN]. IgA glomerulonephritis An autoimmune disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has_material_basis_in mutations in the MEFV gene, which encodes the protein pyrin. GARD:6421 ICD10CM:M04.1 ICD9CM:277.31 MESH:D010505 NCI:C84707 OMIM:134610 OMIM:249100 ORDO:342 SNOMEDCT_US_2020_03_01:12579009 UMLS_CUI:C0031069 benign paroxysmal peritonitis disease_ontology DOID:2987 Xref MGI. OMIM mapping confirmed by DO. [SN]. familial Mediterranean fever An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin). GARD:5824 ICD10CM:D68.61 MESH:D016736 NCI:C61283 OMIM:107320 SNOMEDCT_US_2020_03_01:201450008 UMLS_CUI:C0085278 Antiphospholipid syndrome antiphospholipid antibody syndrome disease_ontology DOID:2988 OMIM mapping confirmed by DO. [SN]. antiphospholipid syndrome MESH:D016736 A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue. MESH:D000230 NCI:C2852 SNOMEDCT_US_2020_03_01:443961001 UMLS_CUI:C0001418 disease_ontology DOID:299 adenocarcinoma MESH:D000230 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. DOID:2157 MESH:D009373 NCI:C3708 SNOMEDCT_US_2020_03_01:302853003 UMLS_CUI:C0205851 malignant tumor of the germ cell disease_ontology germ cell neoplasm germ cell tumour DOID:2994 germ cell cancer A sex cord-gonadal stromal tumor characterized by variable proportions of Sertoli cells, Leydig cells, primitive gonadal stroma and/or heterologous elements located_in the ovaries and testicles. DOID:0050618 GARD:9967 MESH:D018310 SNOMEDCT_US_2020_03_01:34110004 UMLS_CUI:C0206723 disease_ontology DOID:2997 Sertoli-Leydig cell tumor A male reproductive system cancer that is located_in the testicles. DOID:12231 DOID:5554 GARD:7746 ICD10CM:C62 ICD9CM:186 MESH:D013736 NCI:C3404 NCI:C5053 NCI:C7251 SNOMEDCT_US_2020_03_01:126900000 SNOMEDCT_US_2020_03_01:94087009 UMLS_CUI:C0039590 UMLS_CUI:C0153594 UMLS_CUI:C1333010 childhood neoplasm of the testis neoplasm of testis pediatric testicular neoplasm testicular tumor testis cancer testis neoplasm disease_ontology DOID:2998 OMIM mapping confirmed by DO. [SN]. testicular cancer A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma. DOID:5333 MESH:D006106 NCI:C3070 NCI:C4205 SNOMEDCT_US_2020_03_01:18861007 SNOMEDCT_US_2020_03_01:46585005 UMLS_CUI:C0018206 UMLS_CUI:C0334401 Granulosa cell neoplasm Granulosa cell tumor, adult type Granulosa cell tumour, sarcomatoid malignant granulosa cell neoplasm disease_ontology DOID:2999 granulosa cell tumor A breast cancer that arises from myoepithelial cells, which are a normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane. NCI:C40389 UMLS_CUI:C1511319 disease_ontology DOID:3004 breast myoepithelial neoplasm A breast carcinoma in situ that is characterized by abnormal cells are found in the lobules (glands that make milk) of the breast. NCI:C27939 UMLS_CUI:C0861352 Lobular Intraepithelial Neoplasia lobular carcinoma in situ disease_ontology DOID:3010 lobular neoplasia A syndrome characterized by autosomal dominant inheritance of increased risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata. GARD:6902 MESH:D016864 NCI:C3476 OMIM:PS151623 ORDO:524 SNOMEDCT_US_2020_03_01:428850001 UMLS_CUI:C0085390 Li-Fraumeni Familiar cancer Susceptibility syndrome SBLA syndrome sarcoma, breast, leukaemia and adrenal gland syndrome disease_ontology DOID:3012 Xref MGI. OMIM mapping confirmed by DO. [SN]. Li-Fraumeni syndrome A breast benign neoplasm that is located_in the breast ducts. NCI:C36083 UMLS_CUI:C0948967 disease_ontology DOID:3013 intraductal breast benign neoplasm A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises_from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s). DOID:1632 DOID:3018 MESH:D003557 NCI:C4275 NCI:C4504 NCI:C7575 SNOMEDCT_US_2020_03_01:254844000 SNOMEDCT_US_2020_03_01:712989008 SNOMEDCT_US_2020_03_01:87913009 UMLS_CUI:C0238031 UMLS_CUI:C0346154 UMLS_CUI:C0600066 Phyllodes breast neoplasm Phyllodes tumor, malignant breast malignant phyllodes tumour malignant Mammary Phyllodes tumor malignant Mammary Phyllodes tumour malignant Phyllodes neoplasm malignant cystosarcoma phyllodes malignant phyllodes tumor malignant phyllodes tumor of breast malignant phyllodes tumour malignant phyllodes tumour of breast phyllodes breast tumor phyllodes breast tumour disease_ontology DOID:3016 breast malignant phyllodes tumor A breast cancer that has_material_basis_in abnormally proliferating cells derives_from mesenchymal cells. NCI:C4670 SNOMEDCT_US_2020_03_01:278050001 UMLS_CUI:C0349667 sarcoma of breast disease_ontology DOID:3017 breast sarcoma A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. MESH:D019966 NCI:C16522 SNOMEDCT_US_2020_03_01:26416006 UMLS_CUI:C0013146 disease_ontology DOID:302 substance abuse A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from spindle cells and/or derives_from giant cells. GARD:8568 MESH:D018267 NCI:C3768 SNOMEDCT_US_2020_03_01:45410002 UMLS_CUI:C0206685 acinic cell carcinoma disease_ontology DOID:3025 acinar cell carcinoma A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. MESH:D019966 NCI:C92203 UMLS_CUI:C0236969 disease_ontology DOID:303 substance-related disorder An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin. DOID:4532 MESH:D002288 NCI:C26712 NCI:C27379 SNOMEDCT_US_2020_03_01:72495009 SNOMEDCT_US_2020_03_01:900006 UMLS_CUI:C0007130 UMLS_CUI:C0334368 Mucin-Secreting adenocarcinoma Mucin-Secreting carcinoma Mucin-producing adenocarcinoma Mucous carcinoma Pseudomyxoma peritonei with unknown primary site mucin-producing adenocarcinoma disease_ontology DOID:3030 mucinous adenocarcinoma A contact dermatitis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign. ICD10CM:L23 MESH:D017449 NCI:C26998 SNOMEDCT_US_2020_03_01:200841005 UMLS_CUI:C0162820 disease_ontology DOID:3042 allergic contact dermatitis A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system. MESH:D005512 SNOMEDCT_US_2020_03_01:213018006 UMLS_CUI:C0016470 food hypersensitivity disease_ontology DOID:3044 food allergy A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding. ICD10CM:M30.1 MESH:D015267 NCI:C34481 SNOMEDCT_US_2020_03_01:82275008 UMLS_CUI:C0008728 Allergic Granulomatous Angiitis Allergic granulomatosis angiitis Churg-Strauss vasculitis disease_ontology DOID:3049 Churg-Strauss syndrome A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. DOID:2428 DOID:6570 MESH:D002277 MESH:D009375 NCI:C2916 NCI:C3709 SNOMEDCT_US_2020_03_01:188083002 SNOMEDCT_US_2020_03_01:269513004 SNOMEDCT_US_2020_03_01:71298006 UMLS_CUI:C0007097 UMLS_CUI:C0553707 UMLS_CUI:C1368683 epithelial cancer epithelioma malignant Epithelioma disease_ontology DOID:305 carcinoma A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly. DOID:13324 DOID:13325 DOID:3053 ICD10CM:A01.1 ICD10CM:A01.2 ICD10CM:A01.3 ICD10CM:A01.4 ICD9CM:002.1 ICD9CM:002.2 ICD9CM:002.3 ICD9CM:002.9 MESH:D010284 NCI:C34894 NCI:C34895 NCI:C34896 NCI:C34897 SNOMEDCT_US_2020_03_01:51254007 SNOMEDCT_US_2020_03_01:71085009 SNOMEDCT_US_2020_03_01:76623002 SNOMEDCT_US_2020_03_01:85904008 UMLS_CUI:C0030528 UMLS_CUI:C0343375 UMLS_CUI:C0343376 UMLS_CUI:C0343377 Paratyphoid Paratyphoid A fever Paratyphoid B fever Paratyphoid C fever Paratyphoid Fever A Paratyphoid Fever B Paratyphoid Fever C Paratyphoid fever A Paratyphoid fever B Paratyphoid fever C paratyphoid a paratyphoid b paratyphoid c disease_ontology DOID:3055 paratyphoid fever An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes. DOID:3075 DOID:3080 GARD:2491 MESH:D005909 NCI:C3058 NCI:C39750 NCI:C9094 SNOMEDCT_US_2020_03_01:63634009 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422 GBM adult glioblastoma multiforme glioblastoma multiforme grade IV adult Astrocytic tumor primary glioblastoma multiforme spongioblastoma multiforme disease_ontology DOID:3068 glioblastoma A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord. DOID:4861 ICDO:M9400/3 MESH:D001254 NCI:C4951 NCI:C60781 SNOMEDCT_US_2020_03_01:189914005 SNOMEDCT_US_2020_03_01:99131000119108 UMLS_CUI:C0004114 UMLS_CUI:C0750935 Astrocytic tumor Astrocytoma, NOS astrocytoma of Cerebrum astrocytoma of brain astroglioma cerebral astrocytoma disease_ontology DOID:3069 astrocytoma MESH:D001254 A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine. DOID:2627 ICDO:M9380/3 KEGG:05214 MESH:D005910 NCI:C4822 OMIM:PS137800 ORDO:182067 SNOMEDCT_US_2020_03_01:393564001 SNOMEDCT_US_2020_03_01:74532006 UMLS_CUI:C0017638 UMLS_CUI:C0555198 Neuroglial tumor glial cell tumor glioma, malignant malignant Neuroglial tumor disease_ontology DOID:3070 Xref MGI. OMIM mapping confirmed by DO. [SN]. malignant glioma A gliomablastoma that is characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation. GARD:5653 MESH:D018316 NCI:C3796 SNOMEDCT_US_2020_03_01:35262004 UMLS_CUI:C0206726 Glioblastoma with sarcomatous component disease_ontology DOID:3071 gliosarcoma MESH:D004831 UMLS_CUI:C0014550 Epileptic seizures - myoclonic Epileptic seizures, myoclonic Myoclonic seizure Myoclonic seizure disorder myoclonia epileptica myoclonic epilepsy disease_ontology DOID:308 early myoclonic encephalopathy GARD:6234 MESH:D018191 NCI:C3724 OMIM:257350 SNOMEDCT_US_2020_03_01:40225001 UMLS_CUI:C0206620 cystic Hygroma disease_ontology DOID:3081 cystic lymphangioma A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough. GARD:13336 ICD10CM:J84.9 MESH:D017563 SNOMEDCT_US_2020_03_01:64667001 UMLS_CUI:C0206062 ILD disease_ontology DOID:3082 interstitial lung disease An obstructive lung disease that is characterized by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease. DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 SNOMEDCT_US_2020_03_01:13645005 UMLS_CUI:C0024117 COLD COPD chronic obstructive airway disease chronic obstructive lung disease disease_ontology DOID:3083 chronic obstructive pulmonary disease ICD10CM:K06.1 MESH:D019214 SNOMEDCT_US_2020_03_01:54711002 UMLS_CUI:C0376480 Gingival enlargement disease_ontology DOID:3086 gingival overgrowth DOID:10422 DOID:10424 ICD10CM:K05.0 ICD10CM:K05.1 ICD10CM:K05.10 ICD9CM:523.0 ICD9CM:523.1 MESH:D005891 NCI:C34474 NCI:C34636 SNOMEDCT_US_2020_03_01:155643004 SNOMEDCT_US_2020_03_01:196355002 SNOMEDCT_US_2020_03_01:266490003 UMLS_CUI:C0008684 UMLS_CUI:C0017574 UMLS_CUI:C0155937 acute gingivitis chronic gingivitis disease_ontology DOID:3087 gingivitis An organ system cancer located_in the nervous system that affects the central or peripheral nervous system. DOID:1193 DOID:3195 DOID:4695 ICD9CM:192.9 MESH:D009380 NCI:C35562 SNOMEDCT_US_2020_03_01:188306000 UMLS_CUI:C0027665 UMLS_CUI:C0153643 UMLS_CUI:C1334956 malignant neoplasm of nervous system neoplasm of nervous system nervous system neoplasm neural neoplasm neural tumor tumor of the nervous system disease_ontology DOID:3093 nervous system cancer A germ cell cancer that is derives_from a mixture of germs cells and embryonal cells. MESH:D009373 UMLS_CUI:C0027658 disease_ontology germ cell and embryonal neoplasm DOID:3095 germ cell and embryonal cancer A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles. GARD:7759 ICD10CM:G54.0 MESH:D013901 NCI:C85188 SNOMEDCT_US_2020_03_01:2040007 UMLS_CUI:C0039984 TOS - Thoracic outlet syndrome disease_ontology DOID:3103 thoracic outlet syndrome A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia. MESH:D001198 SNOMEDCT_US_2020_03_01:2435008 UMLS_CUI:C0003952 disease_ontology DOID:3108 ascaridiasis An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed. MESH:D003536 NCI:C2971 SNOMEDCT_US_2020_03_01:21008007 UMLS_CUI:C0010631 disease_ontology DOID:3111 cystadenocarcinoma An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue. DOID:5596 MESH:D000231 NCI:C2853 SNOMEDCT_US_2020_03_01:4797003 UMLS_CUI:C0001420 Infiltrating and papillary adenocarcinoma Papillary adenocarcinoma infiltrating papillary adenocarcinoma disease_ontology DOID:3112 papillary adenocarcinoma A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue forming serous lesions. MESH:D018284 NCI:C3778 SNOMEDCT_US_2020_03_01:90725004 UMLS_CUI:C0206701 serous adenocarcinoma serous carcinoma disease_ontology DOID:3114 serous cystadenocarcinoma NCI:C7514 UMLS_CUI:C1334323 renal and ureteral tumor disease_ontology DOID:3116 kidney benign neoplasm A gastrointestinal system benign neoplasm located_in the hepatobiliary system. NCI:C8614 UMLS_CUI:C0854196 hepatobiliary tumors disease_ontology DOID:3117 hepatobiliary benign neoplasm A gastrointestinal system disease that is located_in the liver and/or biliary tract. MESH:D004066 NCI:C3959 UMLS_CUI:C0267792 liver and biliary tract disease disease_ontology DOID:3118 hepatobiliary disease An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system. DOID:4945 DOID:8377 ICD10CM:C26.9 ICD9CM:239.0 MESH:D004067 MESH:D005770 NCI:C3052 NCI:C4890 SNOMEDCT_US_2020_03_01:128348002 SNOMEDCT_US_2020_03_01:276806006 SNOMEDCT_US_2020_03_01:428905002 UMLS_CUI:C0012243 UMLS_CUI:C0017185 UMLS_CUI:C0685938 GI tumor digestive system cancer gastrointestinal tract cancer disease_ontology DOID:3119 gastrointestinal system cancer A biliary tract cancer that is located_in the gallbladder. DOID:8090 DOID:8157 GARD:9328 ICD10CM:C23 ICD9CM:156.0 MESH:D005706 NCI:C3048 NCI:C35676 NCI:C7481 SNOMEDCT_US_2020_03_01:126854002 SNOMEDCT_US_2020_03_01:93810008 UMLS_CUI:C0016978 UMLS_CUI:C0153452 UMLS_CUI:C0278806 gallbladder Ca gallbladder neoplasm localized malignant gallbladder neoplasm malignant neoplasm of gallbladder malignant tumor of the gallbladder malignant tumour of gallbladder tumor of the gallbladder disease_ontology DOID:3121 gallbladder cancer MESH:D017219 SNOMEDCT_US_2020_03_01:196759006 UMLS_CUI:C0162651 gastric outflow obstruction disease_ontology DOID:3122 gastric outlet obstruction A syndrome that is characterized by tumors in at least two endocrine glands. Multiple endocrine adenomatosis disease_ontology DOID:3125 multiple endocrine neoplasia A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding. ICD10CM:K62.89 MESH:D011349 NCI:C38011 SNOMEDCT_US_2020_03_01:266534007 UMLS_CUI:C0033246 ulcerative proctitis disease_ontology DOID:3127 proctitis DOID:11479 DOID:11993 MESH:D001004 NCI:C26695 SNOMEDCT_US_2020_03_01:32110003 UMLS_CUI:C0003462 Nontraumatic tear of anus Solitary anal ulcer Ulcer of anus anal disease anal fissure anal fissure and fistula anal ulcer fissure in ano disease_ontology DOID:3128 anus disease An acute porphyria characterized by painful, blistering skin lesions that develop on sun-exposed skin. GARD:7433 ICD10CM:E80.1 MESH:D017119 NCI:C27725 OMIM:176090 OMIM:176100 ORDO:101330 SNOMEDCT_US_2020_03_01:61860000 UMLS_CUI:C0162566 disease_ontology DOID:3132 Xref MGI. OMIM mapping confirmed by DO. [SN]. porphyria cutanea tarda A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis. MESH:D017094 OMIM:612740 ORDO:100924 SNOMEDCT_US_2020_03_01:55056006 UMLS_CUI:C0162533 hepatic porphyria disease_ontology DOID:3133 Xref MGI. acute porphyria MESH:D005148 UMLS_CUI:C0015456 disease_ontology DOID:3134 facial dermatosis MESH:D012536 SNOMEDCT_US_2020_03_01:402694007 UMLS_CUI:C0036271 Dermatosis of scalp disease_ontology DOID:3136 scalp dermatosis GARD:8603 ICD10CM:L83 MESH:D000052 NCI:C26687 OMIM:100600 OMIM:200170 SNOMEDCT_US_2020_03_01:72129000 UMLS_CUI:C0000889 AN - Acanthosis nigricans Acanthosis nigricans Keratosis nigricans keratosis nigricans disease_ontology DOID:3138 OMIM mapping confirmed by DO. [SN]. acanthosis nigricans MESH:D000052 A connective tissue disease characterized by accumulation of glycosaminoglycan located_in the dermal tissue. MESH:D017520 SNOMEDCT_US_2020_03_01:11528001 UMLS_CUI:C0162855 disease_ontology DOID:3141 mucinoses A skin disease characterized by loose, hanging, wrinkled skin lacking in elasticity. GARD:6227 ICD10CM:Q82.8 MESH:D003483 NCI:C84663 OMIM:PS123700 ORDO:209 SNOMEDCT_US_2020_03_01:238825007 UMLS_CUI:C0010495 Cutis laxa loose skin disease_ontology DOID:3144 Xref MGI. cutis laxa An inherited metabolic disorder that involves the creation and degradation of lipids. MESH:D008052 UMLS_CUI:C0023772 dyslipidemia fatty acid metabolism disorder disease_ontology DOID:3146 lipid metabolism disorder ICD10CM:E88.2 MESH:D008068 SNOMEDCT_US_2020_03_01:37095002 UMLS_CUI:C0023801 disease_ontology DOID:3153 lipomatosis MESH:D006229 UMLS_CUI:C0018567 disease_ontology DOID:3158 hand dermatosis MESH:D012878 NCI:C3372 SNOMEDCT_US_2020_03_01:126488004 UMLS_CUI:C0037286 neoplasm of skin neoplasm of skin by site skin neoplasm tumor of the skin disease_ontology DOID:3165 skin benign neoplasm A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities. MESH:D018307 NCI:C3792 SNOMEDCT_US_2020_03_01:118286007 UMLS_CUI:C0206720 Epidermoid cell tumor squamous cell tumor disease_ontology DOID:3168 squamous cell neoplasm MESH:D000236 NCI:C79951 SNOMEDCT_US_2020_03_01:86143001 UMLS_CUI:C0205650 Papillary adenoma glandular papilloma disease_ontology DOID:3172 papillary adenoma NCI:C4101 SNOMEDCT_US_2020_03_01:48218007 UMLS_CUI:C0334243 disease_ontology DOID:3177 verrucous papilloma NCI:C4614 SNOMEDCT_US_2020_03_01:189051001 UMLS_CUI:C0347390 Cutaneous papilloma cutaneous papilloma papilloma of skin disease_ontology DOID:3178 skin papilloma MESH:D018308 NCI:C3793 SNOMEDCT_US_2020_03_01:104081000119103 UMLS_CUI:C0206721 Inverted papilloma Inverted papilloma, squamous cell disease_ontology DOID:3179 inverted papilloma ICD9CM:335.21 MESH:D009134 NCI:C85027 SNOMEDCT_US_2020_03_01:88923002 UMLS_CUI:C0917981 Pure progressive muscular atrophy progressive spinal muscular atrophy disease_ontology DOID:318 progressive muscular atrophy DOID:3182 GARD:9953 MESH:D009837 NCI:C129319 NCI:C6960 SNOMEDCT_US_2020_03_01:73348003 UMLS_CUI:C0028945 UMLS_CUI:C1335110 oligodendroglial neoplasm oligodendroglial tumor disease_ontology DOID:3181 oligodendroglioma A spinal cancer that is located in the spinal cord and has_material_basis_in glial cells. NCI:C4534 SNOMEDCT_US_2020_03_01:254946004 UMLS_CUI:C2937245 Glial neoplasm Spinal Cord Glial tumor of spinal cord glioma of spinal cord disease_ontology DOID:3185 spinal cord glioma ICD10CM:G95.9 ICD9CM:336.9 MESH:D013118 NCI:C97110 SNOMEDCT_US_2020_03_01:48522003 UMLS_CUI:C0037928 disease_ontology myelopathy DOID:319 spinal cord disease A congenital structural myopathy characterized by generally non-progressive muscle weakness of varying severity; certain muscle fibers show the presence of rod-like structures called nemaline bodies. GARD:12033 ICD10CM:G71.2 MESH:D017696 OMIM:PS161800 ORDO:607 SNOMEDCT_US_2020_03_01:75072002 UMLS_CUI:C0206157 Nemaline body disease nemaline rod myopathy rod myopathy disease_ontology DOID:3191 Xref MGI. nemaline myopathy MESH:D009442 NCI:C3269 SNOMEDCT_US_2020_03_01:985004 UMLS_CUI:C0027809 Psammomatous schwannoma schwannoma disease_ontology DOID:3192 A neuroma that is characterized as a benign nerve sheath tumor that is composed of Schwann cells. neurilemmoma A peripheral nervous system neoplasm that is located in the connective tissue surrounding nerves. MESH:D018317 UMLS_CUI:C0751689 neoplasm of the nerve Sheath nerve sheath tumour disease_ontology DOID:3193 peripheral nerve sheath neoplasm A brain stem cancer that is characterized by neoplasms in the fossa located_in cerebellopotine angle. NCI:C5414 Cerebellopontine angle tumor Cerebellopontine angle tumour cerebellopontine angle tumour neoplasm of the Cerebellopontine Angle disease_ontology DOID:3200 cerebellopontine angle tumor NCI:C6970 SNOMEDCT_US_2020_03_01:253088003 UMLS_CUI:C1306247 Melanotic Schwannoma Melanotic neurilemmoma Pigmented Neurilemmoma Pigmented schwannoma disease_ontology DOID:3205 melanotic neurilemmoma An epidermolysis bullosa that is characterized by recurrent blistering located in the lamina lucida of the basement membrane secondary to minor trauma, which can cause limited wounds, dehydration, electrolyte abnormalities, severe infection, among other issues, and has_material_basis_in mutation in genes related to laminin 332, which strengthens the skin. GARD:2152 MESH:D016109 NCI:C90598 SNOMEDCT_US_2020_03_01:76905008 UMLS_CUI:C0079301 congenital junctional epidermolysis bullosa disease_ontology DOID:3209 Xref MGI. junctional epidermolysis bullosa A viral infectious disease that results in inflammation located in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms. ICD10CM:G04.1 MESH:D015493 OMIM:159580 SNOMEDCT_US_2020_03_01:45129002 UMLS_CUI:C0030481 HTLV-associated myelopathy Tropical spastic paralysis Tropical spastic paraplegia disease_ontology DOID:321 OMIM mapping confirmed by DO. [LS]. tropical spastic paraparesis A hypomyelinating leukodystrophy characterized by impaired myelin formation, nystagmus, spastic quadriplegia, ataxia, and developmental delay that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22. GARD:4265 MESH:D020371 NCI:C75487 OMIM:312080 ORDO:702 SNOMEDCT_US_2020_03_01:64855000 UMLS_CUI:C0205711 HLD1 Leukodystrophy, sudanophilic PMD Pelizaeus Merzbacher brain sclerosis Pelizaeus-Merzbacher brain sclerosis diffuse familial brain sclerosis hypomyelinating leukodystrophy 1 sudanophilic leukodystrophy, Paelizeus-Merzbacher type disease_ontology DOID:3210 Pelizaeus-Merzbacher disease An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function. MESH:D016464 NCI:C61250 SNOMEDCT_US_2020_03_01:23585005 UMLS_CUI:C0085078 disorder of lysosomal enzyme inborn lysosomal enzyme disorder lysosomal storage metabolism disorder disease_ontology DOID:3211 lysosomal storage disease A neurodegenerative disease that is characterized by damage to the myelin sheath present around nerve axons. MESH:D003711 NCI:C34527 UMLS_CUI:C0011303 demyelinating disorder disease_ontology DOID:3213 demyelinating disease A spinal cord disease that is characterized by inflammation of the white matter or gray matter of the spinal cord. GARD:7130 MESH:D009187 NCI:C26832 SNOMEDCT_US_2020_03_01:192682002 UMLS_CUI:C0026975 disease_ontology DOID:322 myelitis GARD:4647 MESH:D020918 SNOMEDCT_US_2020_03_01:128200000 UMLS_CUI:C0458219 Complex regional pain syndromes disease_ontology DOID:3223 complex regional pain syndrome ICD10CM:S12.8 MESH:D014133 NCI:C35079 SNOMEDCT_US_2020_03_01:47125007 UMLS_CUI:C0040580 disease_ontology DOID:3225 tracheal disease MESH:D014135 NCI:C78646 SNOMEDCT_US_2020_03_01:11296007 UMLS_CUI:C0040583 Stenosis of trachea disease_ontology DOID:3227 tracheal stenosis MESH:D014135 MESH:D013271 UMLS_CUI:C0038353 stomach dilatation disease_ontology DOID:3229 gastric dilatation MESH:D006610 UMLS_CUI:C0019537 disease_ontology DOID:3230 high pressure neurological syndrome A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system. DOID:3233 ICD9CM:200.5 NCI:C9301 SNOMEDCT_US_2020_03_01:307649006 UMLS_CUI:C0280803 Microglioma primary CNS lymphoma disease_ontology DOID:3234 central nervous system lymphoma A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disease has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration. DOID:13016 DOID:13506 ICD10CM:J69.0 MESH:D011015 SNOMEDCT_US_2020_03_01:47839005 UMLS_CUI:C0032290 Chemical pneumonitis Mendelson's Syndrome disease_ontology DOID:3240 aspiration pneumonitis An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent. DOID:13015 ICD10CM:J69.1 MESH:D011017 SNOMEDCT_US_2020_03_01:196038008 UMLS_CUI:C0032298 Exogenous lipoid pneumonia Lipoid pneumonitis disease_ontology DOID:3241 lipid pneumonia A rhabdomyosarcoma wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo; it occurs most often in the head and neck area or in the genital or urinary organs. GARD:4702 MESH:D018233 NCI:C8971 OMIM:268210 ORDO:99757 SNOMEDCT_US_2020_03_01:404051002 UMLS_CUI:C0206656 disease_ontology DOID:3246 Xref MGI. embryonal rhabdomyosarcoma A skeletal muscle cancer that arise from skeletal muscle progenitors. MESH:D012208 NCI:C3359 SNOMEDCT_US_2020_03_01:302847003 UMLS_CUI:C0035412 disease_ontology DOID:3247 rhabdomyosarcoma A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate. NCI:C5522 UMLS_CUI:C1335518 Rhabdomyosarcoma of the prostate disease_ontology DOID:3252 prostate rhabdomyosarcoma A vascular disease that is characterized by a restriction in blood supply to tissues. MESH:D007511 NCI:C34738 SNOMEDCT_US_2020_03_01:52674009 UMLS_CUI:C0022116 disease_ontology DOID:326 ischemia A hyper IgE syndrome that has_material_basis_in heterozygous mutation in the STAT3 gene on chromosome 17q21. GARD:6800 MESH:D007589 NCI:C126342 OMIM:147060 ORDO:2314 UMLS_CUI:C1968689 UMLS_CUI:C2936739 Job syndrome Job's syndrome hyperimmunoglobulin E syndrome disease_ontology DOID:3261 OMIM mapping confirmed by DO. [SN]. hyper IgE recurrent infection syndrome 1 A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection. MESH:D010585 UMLS_CUI:C0031306 phagocytic dysfunction disease_ontology DOID:3262 phagocyte bactericidal dysfunction MESH:D010585 An integumentary system disease characterized by congenital absence of melanocytes in areas of the skin and hair that has_material_basis_in heterozygous mutation in either KIT or SNAI2 on chromosome 4q12 or 8q11.21, respectively. GARD:4344 ICD10CM:E70.39 MESH:D016116 NCI:C85009 OMIM:172800 ORDO:2884 SNOMEDCT_US_2020_03_01:718122005 UMLS_CUI:C0080024 PIEBALD TRAIT Partial albinism disease_ontology DOID:3263 OMIM mapping confirmed by DO. [SN]. piebaldism A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed. GARD:6100 ICD10CM:D71 MESH:D006105 NCI:C26788 ORDO:379 SNOMEDCT_US_2020_03_01:11210002 UMLS_CUI:C0018203 Bridges-Good syndrome CGD Congenital dysphagocytosis Quie syndrome disease_ontology DOID:3265 Xref MGI. OMIM mapping confirmed by DO. [SN]. chronic granulomatous disease An ovarian benign neoplasm that has_material_basis_in glandular epithelial tissue in which cystic accumulations of retained secretions are formed. NCI:C4060 SNOMEDCT_US_2020_03_01:198297004 UMLS_CUI:C0346169 Cystoma Serosum simplex simple cystoma of ovary simple cystoma of the ovary disease_ontology DOID:3269 ovarian cystadenoma GARD:7725 MESH:D013595 NCI:C85179 OMIM:186700 ORDO:3280 SNOMEDCT_US_2020_03_01:155020007 UMLS_CUI:C0039144 disease_ontology DOID:327 syringomyelia A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus. MESH:D013945 NCI:C3411 SNOMEDCT_US_2020_03_01:444231005 UMLS_CUI:C0040100 disease_ontology DOID:3275 thymoma An immune system cancer located_in the thymus. DOID:10143 ICD10CM:C37 ICD9CM:164.0 MESH:D013953 NCI:C4962 SNOMEDCT_US_2020_03_01:94096009 UMLS_CUI:C0751552 Thymic tumor neoplasm of thymus thymic neoplasm disease_ontology DOID:3277 thymus cancer NCI:C7114 UMLS_CUI:C1328042 epithelioid Thymoma disease_ontology DOID:3282 dendritic cell thymoma A thymus cancer that derives_from epithelial cells. The tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found. MESH:D013945 NCI:C7569 SNOMEDCT_US_2020_03_01:128717008 UMLS_CUI:C0205969 Thymic carcinoma Thymoma, malignant malignant Thymoma disease_ontology DOID:3284 thymic carcinoma A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has_material_basis_in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy. GARD:10722 ICD10CM:B04 ICD9CM:059.01 MESH:D045908 NCI:C128421 SNOMEDCT_US_2020_03_01:240466002 UMLS_CUI:C0276180 disease_ontology DOID:3292 monkeypox A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches. MESH:D014615 SNOMEDCT_US_2020_03_01:111852003 UMLS_CUI:C0042214 disease_ontology DOID:3298 vaccinia A cell type benign neoplasm that is composed_of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells (which comprises the granulosa, theca, and fibrocyte cells). MESH:D018238 NCI:C3754 OMIM:424500 SNOMEDCT_US_2020_03_01:74751003 UMLS_CUI:C0206661 disease_ontology DOID:3301 OMIM mapping confirmed by DO. [SN]. gonadoblastoma A notochordal cancer that derives_from cellular remnants of the notochord. GARD:1303 MESH:D002817 NCI:C2947 SNOMEDCT_US_2020_03_01:50007008 UMLS_CUI:C0008487 notochordoma disease_ontology DOID:3302 OMIM mapping confirmed by DO. [SN]. chordoma An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord. NCI:C7063 UMLS_CUI:C1335069 disease_ontology notochordal tumor DOID:3303 notochordal cancer A germ cell cancer that lacks histologic differentiation. It usually refers to a tumor in the brain. MESH:D018237 NCI:C3753 SNOMEDCT_US_2020_03_01:154603000 UMLS_CUI:C0206660 disease_ontology DOID:3304 germinoma A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both. MESH:D018243 NCI:C3756 SNOMEDCT_US_2020_03_01:67830002 UMLS_CUI:C0206664 Teratocarcinoma mixed Embryonal carcinoma and teratoma disease_ontology DOID:3305 teratocarcinoma A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers. MESH:D013724 NCI:C3403 SNOMEDCT_US_2020_03_01:36591000119102 UMLS_CUI:C0039538 disease_ontology DOID:3307 teratoma An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes. DOID:5676 GARD:5140 MESH:D018236 NCI:C3752 NCI:C8880 SNOMEDCT_US_2020_03_01:28047004 UMLS_CUI:C0206659 UMLS_CUI:C0855159 primary extragonadal embryonal carcinoma disease_ontology DOID:3308 embryonal carcinoma A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system. ICD10CM:G96.9 MESH:D002493 NCI:C2934 SNOMEDCT_US_2020_03_01:267144009 UMLS_CUI:C0007682 disease_ontology DOID:331 central nervous system disease An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking. EFO:0000274 ICD10CM:L20 MESH:D003876 OMIM:603165 OMIM:PS603165 SNOMEDCT_US_2020_03_01:156331003 UMLS_CUI:C0011615 Atopic dermatitis Atopic neurodermatitis Besnier's prurigo allergic dermatitis atopic eczema disease_ontology DOID:3310 Xref MGI. OMIM mapping confirmed by DO. [SN]. atopic dermatitis A mood disorder that involves alternating periods of mania and depression. DOID:3311 DOID:9554 DOID:9555 EFO:0000289 GARD:10249 ICD10CM:F31 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 SNOMEDCT_US_2020_03_01:16506000 SNOMEDCT_US_2020_03_01:191627008 SNOMEDCT_US_2020_03_01:192355004 SNOMEDCT_US_2020_03_01:68569003 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780 Manic Bipolar Affective disorder Manic Depressive disorder Manic bipolar I disorder bipolar depression bipolar disorder manic phase manic depression manic disorder mixed bipolar disorder disease_ontology Depressive-manic psych. DOID:3312 bipolar disorder A cell type benign neoplasm that is primarily located in the kidneys but may be found in the lungs, liver or other organs and is derived from perivascular epithelioid cells. MESH:D018207 NCI:C3734 SNOMEDCT_US_2020_03_01:19929002 UMLS_CUI:C0206633 Angiomyolipoma disease_ontology DOID:3314 angiomyolipoma MESH:D018207 A cell type benign neoplasm that is composed of lipocytes. DOID:3154 DOID:9291 ICD10CM:D17 ICD10CM:D17.9 ICD9CM:214 MESH:D008067 MESH:D018205 NCI:C3192 NCI:C4248 NCI:C4502 OMIM:151900 SNOMEDCT_US_2020_03_01:115227001 SNOMEDCT_US_2020_03_01:154612003 SNOMEDCT_US_2020_03_01:254830006 UMLS_CUI:C0023798 UMLS_CUI:C0206631 UMLS_CUI:C0346118 LIPOMATOSIS, FAMILIAL MULTIPLE Lipomatous neoplasm Lipomatous tumor benign lipomatous tumor benign tumor of Adipose tissue multiple lipomatosis tumor of adipose tissue disease_ontology DOID:3315 OMIM mapping confirmed by DO. [SN]. lipoma DOID:5234 NCI:C6528 NCI:C6530 UMLS_CUI:C1334611 UMLS_CUI:C1335392 malignant perivascular cancer disease_ontology DOID:3316 perivascular tumor A lung disease that is characterized by progressive cystic destruction of the lung and lymphatic abnormalities, frequently associated with renal angiomyolipomas. DOID:3682 GARD:3319 NCI:C38153 OMIM:606690 ORDO:538 SNOMEDCT_US_2020_03_01:277844007 UMLS_CUI:C0349649 lung lymphangioleiomyomatosis lymphangiomyomatosis pulmonary lymphangioleiomyomatosis disease_ontology DOID:3319 lymphangioleiomyomatosis MESH:D018192 A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. EFO:0000253 GARD:5786 ICD10CM:G12.21 ICD9CM:335.20 KEGG:05014 MESH:D000690 NCI:C34373 OMIM:PS105400 ORDO:803 SNOMEDCT_US_2020_03_01:86044005 UMLS_CUI:C0002736 ALS Lou Gehrig's disease motor neuron disease, bulbar disease_ontology DOID:332 amyotrophic lateral sclerosis MESH:D000690 GARD:7737 ICD10CM:E75.02 MESH:D013661 NCI:C85184 OMIM:272800 SNOMEDCT_US_2020_03_01:111385000 UMLS_CUI:C0039373 A GM2 gangliosidosis that is characterized the onset in infancy of developmental retardation, followed by paralysis, dementia and blindness, with death in the second or third year of life and has_material_basis_in homozygous or compound heterozygous mutation in the alpha subunit of the hexosaminidase A gene (HEXA) on chromosome 15q23. GM2 gangliosidosis, type 1 hexosaminidase A deficiency disease_ontology DOID:3320 OMIM mapping confirmed by DO. [SN]. Tay-Sachs disease A gangliosidosis that is characterized by excessive accumulation of ganglioside GM2 and related glycolipids in the lysosomes. ICD10CM:E75.0 MESH:D020143 SNOMEDCT_US_2020_03_01:33316007 UMLS_CUI:C0268274 gangliosidosis GM2 disease_ontology DOID:3321 GM2 gangliosidosis A GM2 gangliosidosis that is characterized by an accumulation of GM2 gangliosides, particularly in neurons, and that has_material_basis_in mutation in the beta subunit of hexosaminidase (HEXB) on chromosome 5q13. GARD:7604 ICD10CM:E75.01 MESH:D012497 NCI:C85052 OMIM:268800 SNOMEDCT_US_2020_03_01:23849003 UMLS_CUI:C0036161 Sandhoff Jatzkewitz disease disease_ontology DOID:3323 OMIM mapping confirmed by DO. [SN]. Sandhoff disease MESH:D012497 A cognitive disorder that involves a disturbance in mood as the predominant underlying feature. EFO:0004247 ICD10CM:F39 MESH:D019964 NCI:C92200 SNOMEDCT_US_2020_03_01:46206005 UMLS_CUI:C0525045 episodic mood disorder disease_ontology DOID:3324 Updating outdated UMLS CUI. mood disorder MESH:D011694 SNOMEDCT_US_2020_03_01:402852007 UMLS_CUI:C0034151 disease_ontology DOID:3325 hyperglobulinemic purpura ICD10CM:D69.2 MESH:D011693 NCI:C78787 SNOMEDCT_US_2020_03_01:423902002 UMLS_CUI:C0034150 Purpuric disorder disease_ontology DOID:3326 purpura MESH:D011693 MESH:D019305 OMIM:117100 UMLS_CUI:C0376532 BCECTS benign Rolandic epilepsy benign childhood epilepsy with centrotemporal spike rolandic epilepsy sylvan seizures disease_ontology DOID:3329 benign epilepsy with centrotemporal spikes A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood. ICD10CM:F60.4 ICD9CM:301.5 MESH:D006677 NCI:C92634 SNOMEDCT_US_2020_03_01:192489002 UMLS_CUI:C0019681 disease_ontology DOID:334 histrionic personality disorder A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone. MESH:D010002 NCI:C34875 SNOMEDCT_US_2020_03_01:190451000 UMLS_CUI:C0029405 Osteitis fibrosa cystica generalisata Von Recklinghausen's bone disease hyperparathyroid bone disease disease_ontology DOID:3341 osteitis fibrosa A bone disease that results_in inflammation of the located_in bone. MESH:D010000 SNOMEDCT_US_2020_03_01:274144001 UMLS_CUI:C0029400 Inflammatory disorder of bone bone inflammatory disease osteitis disease_ontology DOID:3342 bone inflammation disease A mucolipidosis that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase). GARD:10670 MESH:D009081 NCI:C61267 OMIM:256550 SNOMEDCT_US_2020_03_01:70528007 UMLS_CUI:C0026697 Mucolipidosis type I sialidosis disease_ontology DOID:3343 OMIM mapping submitted by NeuroDevNet. [LS]. glycoproteinosis A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts. MESH:D014973 SNOMEDCT_US_2020_03_01:63103006 UMLS_CUI:C0043325 xanthelasmatosis disease_ontology DOID:3345 xanthomatosis A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin. DOID:183 GARD:7284 MESH:D012516 MESH:D018213 NCI:C9145 OMIM:259500 ORDO:668 SNOMEDCT_US_2020_03_01:189878003 UMLS_CUI:C0029463 UMLS_CUI:C0206639 Osteogenic sarcoma Skeletal sarcoma bone tissue neoplasm osteoid sarcoma disease_ontology DOID:3347 OMIM mapping confirmed by DO. [SN]. osteosarcoma A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system. DOID:1630 NCI:C6587 NCI:C7059 UMLS_CUI:C1332517 UMLS_CUI:C1334699 benign miscellaneous mesenchymal tumor mesenchymal tumor disease_ontology DOID:3350 mesenchymal cell neoplasm A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. DOID:156 DOID:3509 GARD:2327 MESH:D005354 MESH:D018218 NCI:C3043 NCI:C6605 NCI:C7075 SNOMEDCT_US_2020_03_01:443250000 UMLS_CUI:C0016057 UMLS_CUI:C0206643 UMLS_CUI:C1336021 Fibrocytic tumor fibrosarcoma of soft tissue fibrous tissue neoplasm disease_ontology DOID:3355 fibrosarcoma NCI:C7780 UMLS_CUI:C0278511 localised Osteogenic sarcoma localised osteosarcoma localized Osteogenic sarcoma disease_ontology DOID:3356 localized osteosarcoma GARD:6200 ICD10CM:I25.41 ICD9CM:414.11 MESH:D003323 SNOMEDCT_US_2020_03_01:50570003 UMLS_CUI:C0010051 Aneurysm of coronary vessels Aneurysmal lesion of coronary artery Arteriovenous aneurysm of coronary vessels disease_ontology DOID:3362 coronary aneurysm A connective tissue cancer that has_material_basis in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm. DOID:0050607 DOID:4158 DOID:4390 DOID:4391 DOID:4392 DOID:4980 GARD:6390 MESH:C563168 MESH:D012512 MESH:D018241 NCI:C27901 NCI:C27903 NCI:C4817 NCI:C7542 NCI:C7806 NCI:C9341 OMIM:612219 SNOMEDCT_US_2020_03_01:134210007 SNOMEDCT_US_2020_03_01:73676002 SNOMEDCT_US_2020_03_01:76909002 UMLS_CUI:C0553580 UMLS_CUI:C0684337 UMLS_CUI:C0796547 UMLS_CUI:C0863029 UMLS_CUI:C0877849 UMLS_CUI:C1334408 Ewing's family localized tumor Ewing's sarcoma/peripheral primitive neuroectodermal tumor Ewing's tumor Ewings sarcoma Ewings sarcoma-primitive neuroectodermal tumor PNET of Thoracopulmonary Region localized Ewing sarcoma localized Ewing's sarcoma localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor localized Ewing's tumor localized peripheral primitive neuroectodermal tumor peripheral primitive neuroectodermal tumor disease_ontology DOID:3369 OMIM mapping confirmed by DO. [SN]. Ewing sarcoma A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage. DOID:3370 GARD:6004 GARD:6055 MESH:D002813 NCI:C2946 NCI:C7155 OMIM:215300 SNOMEDCT_US_2020_03_01:443520009 SNOMEDCT_US_2020_03_01:735679005 UMLS_CUI:C0008479 UMLS_CUI:C1335473 Cartilaginous cancer chondrosarcoma of bone primary chondrosarcoma of the bone disease_ontology DOID:3371 OMIM mapping confirmed by DO. [SN]. chondrosarcoma MESH:D018217 NCI:C8969 SNOMEDCT_US_2020_03_01:91242000 UMLS_CUI:C0206642 Parosteal Osteogenic sarcoma Parosteal Osteosarcoma disease_ontology DOID:3373 juxtacortical osteosarcoma NCI:C7134 UMLS_CUI:C1332591 Surface Osteosarcoma disease_ontology DOID:3374 peripheral osteosarcoma DOID:8580 NCI:C53707 SNOMEDCT_US_2020_03_01:307576001 UMLS_CUI:C0585442 Osteosarcoma of bone primary Osteosarcoma of bone disease_ontology DOID:3376 bone osteosarcoma NCI:C4023 SNOMEDCT_US_2020_03_01:12302002 UMLS_CUI:C0279622 Round cell osteosarcoma small cell Osteosarcoma disease_ontology DOID:3377 small cell osteogenic sarcoma Medullary Osteosarcoma Medullary osteosarcoma conventional Osteosarcoma disease_ontology DOID:3378 conventional central osteosarcoma A central nervous system cancer develops from schwann cells located_in cranial nerves, has_material_basis_in abnormally proliferating cells. MESH:D003390 NCI:C2963 SNOMEDCT_US_2020_03_01:126966009 UMLS_CUI:C0010267 neoplasm of cranial nerve disease_ontology DOID:338 cranial nerve neoplasm A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum and the extremities. GARD:6913 MESH:D008080 NCI:C3194 SNOMEDCT_US_2020_03_01:254829001 UMLS_CUI:C0023827 disease_ontology DOID:3382 liposarcoma A vaginitis that is characterized by a grayish vaginal discharge usually of foul odor and the presence of Gardnerella vaginalis. MESH:D016585 NCI:C116973 SNOMEDCT_US_2020_03_01:237092002 UMLS_CUI:C0085166 disease_ontology DOID:3385 bacterial vaginosis A mouth disease that is relating to or affecting the structures surrounding and supporting the teeth. ICD10CM:K05.6 MESH:D010510 NCI:C63743 SNOMEDCT_US_2020_03_01:196354003 UMLS_CUI:C0031090 Periodontal disease disease of supporting structures of teeth periodontium disorder disease_ontology DOID:3388 periodontal disease An ectodermal dysplasia that is characterized by palmoplantar keratoderma associated with early-onset periodontitis and has_material_basis_in homozygous or compound heterozygous mutation in the cathepsin C gene on chromosome 11q14. GARD:3100 MESH:D010214 NCI:C84992 OMIM:245000 ORDO:678 SNOMEDCT_US_2020_03_01:40158001 UMLS_CUI:C0030360 Papillon Lefevre syndrome Papillon-Lefvre syndrome disease_ontology DOID:3389 OMIM mapping confirmed by DO. [SN]. Papillon-Lefevre disease A keratosis characterized by abnormal thickening of the palms and the soles. GARD:8167 ICD10CM:L85.2 SNOMEDCT_US_2020_03_01:28596004 UMLS_CUI:C0022596 Keratosis palmaris et plantaris Palmoplantar Keratoderma palmo-plantar keratodermas disease_ontology DOID:3390 palmoplantar keratosis An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.1 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 SNOMEDCT_US_2020_03_01:194852007 SNOMEDCT_US_2020_03_01:233822007 SNOMEDCT_US_2020_03_01:41702007 SNOMEDCT_US_2020_03_01:53741008 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694 CHD Coronary disease coronary arteriosclerosis coronary heart disease disease_ontology DOID:3393 Xref MGI. coronary artery disease ICD10CM:E22.2 MESH:D007177 NCI:C3988 SNOMEDCT_US_2020_03_01:55004003 UMLS_CUI:C0021141 syndrome of Inappropriate Antidiuretic Hormone Secretion syndrome of inappropriate secretion of ADH syndrome of inappropriate secretion of antidiuretic hormone syndrome of inappropriate vasopressin secretion disease_ontology DOID:3401 inappropriate ADH syndrome MESH:D007177 A lymphatic system disease that is characterized by an excessive number of histiocytes. DOID:3344 MESH:D015614 NCI:C3106 SNOMEDCT_US_2020_03_01:60657004 UMLS_CUI:C0019618 Hand Schuller Christian disease chronic Histiocytosis X disease_ontology DOID:3405 histiocytosis MESH:D002340 NCI:C84476 SNOMEDCT_US_2020_03_01:371160000 UMLS_CUI:C0007273 disorder of carotid artery disease_ontology DOID:3407 carotid artery disease A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain. DOID:2868 ICD9CM:443.81 MESH:D001157 SNOMEDCT_US_2020_03_01:195624006 SNOMEDCT_US_2020_03_01:2929001 UMLS_CUI:C0003838 UMLS_CUI:C0031115 arterial occlusive disease disease_ontology DOID:341 peripheral vascular disease A lysosomal storage disease that has_material_basis_in deficiency of the alpha-D-manosidase enzyme resulting in the impairment of cell function from a build up of complex sugars derived from glycoproteins in the lysosome. GARD:6968 MESH:D008363 NCI:C84548 OMIM:248500 SNOMEDCT_US_2020_03_01:65524005 UMLS_CUI:C0024748 Alpha-D-mannosidosis alpha-mannosidase deficiency deficiency of alpha-mannosidase disease_ontology DOID:3413 OMIM mapping confirmed by DO. [SN]. alpha-mannosidosis MESH:D008363 A cranial nerve disease that is located_in the ninth cranial nerve or its nuclei in the medulla. ICD10CM:G52 ICD9CM:352 SNOMEDCT_US_2020_03_01:193098000 UMLS_CUI:C0154730 ninth cranial nerve disease disease_ontology DOID:3418 glossopharyngeal nerve disease MESH:D019574 NCI:C4801 SNOMEDCT_US_2020_03_01:126968005 UMLS_CUI:C0524802 Tumour of optic nerve neoplasm of optic nerve tumor of Second Cranial nerve disease_ontology DOID:3419 optic nerve neoplasm ICD9CM:442.82 SNOMEDCT_US_2020_03_01:40136003 UMLS_CUI:C0155746 disease_ontology DOID:342 subclavian artery aneurysm ICD10CM:H81.9 MESH:D015837 SNOMEDCT_US_2020_03_01:20425006 UMLS_CUI:C0042594 Vertigo, vestibular disorder disease_ontology DOID:3426 vestibular disease A myositis that is characterized by late onset of skeletal muscle inflammation, weakness, and atrophy with cytoplasmic granules and vacuoles in the muscle. GARD:3896 ICD10CM:G72.41 ICD9CM:359.71 MESH:D018979 NCI:C84786 OMIM:147421 ORDO:611 SNOMEDCT_US_2020_03_01:72315009 UMLS_CUI:C0238190 disease_ontology DOID:3429 OMIM mapping confirmed by DO. [SN]. inclusion body myositis MESH:D018979 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption. MESH:D007827 NCI:C26811 SNOMEDCT_US_2020_03_01:45913009 UMLS_CUI:C0023067 disease_ontology DOID:3437 laryngitis A breast adenocarcinoma that has_material_basis_in epidermal Paget cells, which are malignant glandular epithelial cells with abundant and clear cytoplasm, usually containing mucin, and pleomorphic and hyperchromatic nucleus. NCI:C7073 UMLS_CUI:C1368019 Paget cell neoplasm Paget's disease Paget's disease of the breast mammary Paget disease disease_ontology DOID:3443 mammary Paget's disease NCI:C5598 UMLS_CUI:C1332274 Paget's disease of anus anal Paget disease disease_ontology Paget's disease of the anus DOID:3446 anal Paget's disease An anal carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin. NCI:C5600 SNOMEDCT_US_2020_03_01:423607006 UMLS_CUI:C1332257 adenocarcinoma of anus disease_ontology adenocarcinoma of the anus DOID:3447 anus adenocarcinoma A penile cancer that is located_in the skin or tissues of the penis. NCI:C9061 SNOMEDCT_US_2020_03_01:372106005 UMLS_CUI:C0853105 Penile carcinoma carcinoma of penis disease_ontology DOID:3449 penis carcinoma A female reproductive system disease that is located_in the uterus. ICD10CM:N85.9 ICD9CM:621.9 MESH:D014591 NCI:C26907 SNOMEDCT_US_2020_03_01:237068005 UMLS_CUI:C0042131 disease_ontology DOID:345 uterine disease A skin cancer that is located_in tissues of the skin and develops from epithelial cells. NCI:C4914 UMLS_CUI:C0699893 carcinoma of skin disease_ontology DOID:3451 skin carcinoma A cerebrovascular disease that is characterized by tissue necrosis located_in the brain, resulting from inadequate blood flow through the brain. MESH:D020520 UMLS_CUI:C0751955 disease_ontology DOID:3454 brain infarction A breast lobular carcinoma that is characterized by infiltration into the tissue of the breast outside of the lobule where it originated. MESH:D018275 NCI:C3771 SNOMEDCT_US_2020_03_01:89740008 UMLS_CUI:C0206692 Lobular carcinoma Lobular carcinoma of breast Lobular carcinoma of the breast disease_ontology DOID:3457 invasive lobular carcinoma A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast. NCI:C5214 UMLS_CUI:C0858252 Mammary adenocarcinoma disease_ontology adenocarcinoma of breast DOID:3458 breast adenocarcinoma A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. EFO:0000305 MESH:D001943 NCI:C4872 SNOMEDCT_US_2020_03_01:154513000 UMLS_CUI:C0678222 Mammary carcinoma carcinoma of breast disease_ontology DOID:3459 breast carcinoma A thoracic disease that is located_in the breast. ICD10CM:N64.9 ICD9CM:610-612.99 MESH:D001941 NCI:C26709 SNOMEDCT_US_2020_03_01:79604008 UMLS_CUI:C0006145 disease_ontology DOID:3463 breast disease An ocular cancer that is located_in the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid. The uvea is the most common location of intraocular malignancy in adults and may commonly be caused by a subtype of cancer that arises from melanocytes. DOID:12754 MESH:D014604 NCI:C3436 NCI:C6105 UMLS_CUI:C0042162 UMLS_CUI:C1334629 Uveal tumor malignant Uveal tumor malignant uvea neoplasm disease_ontology DOID:3479 uveal cancer An eyelid disease that is characterized by exacerbations and remissions of eyelid edema, which results in a stretching and subsequent atrophy of the eyelid tissue, leading to the formation of redundant folds over the lid margins. ICD10CM:H02.3 ICD9CM:374.34 SNOMEDCT_US_2020_03_01:193944001 UMLS_CUI:C0005742 disease_ontology DOID:348 blepharochalasis An eye disease affecting the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid. GARD:8192 MESH:D014603 NCI:C26908 SNOMEDCT_US_2020_03_01:95678007 UMLS_CUI:C0042161 disease_ontology DOID:3480 uveal disease A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food. ICD10CM:A20 ICD9CM:020 MESH:D010930 NCI:C85015 SNOMEDCT_US_2020_03_01:58750007 UMLS_CUI:C0032064 disease_ontology DOID:3482 plague GARD:8616 ICD10CM:D47.02 MESH:D034721 NCI:C9235 SNOMEDCT_US_2020_03_01:123310005 UMLS_CUI:C0221013 SMCD - systemic mast cell disease systemic tissue mast cell disease disease_ontology DOID:349 systemic mastocytosis A RASopathy that is characterized by mildly unusual facial features, short stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms. GARD:10955 ICD10CM:Q87.19 MESH:D009634 NCI:C34854 OMIM:PS163950 ORDO:648 SNOMEDCT_US_2020_03_01:88327006 UMLS_CUI:C0028326 Turner's phenotype, karyotype normal disease_ontology DOID:3490 OMIM mapping confirmed by DO. [SN]. Noonan syndrome A gonadal dysgenesis that is characterized by short stature and early loss of ovarian function resulting from ovarian hypofunction or premature ovarian failure and has_material_basis_in one missing or structurally altered X chromosome. DOID:5448 GARD:2540 GARD:7831 ICD10CM:Q96 MESH:D014424 NCI:C26900 NCI:C34434 SNOMEDCT_US_2020_03_01:38804009 UMLS_CUI:C0041408 UMLS_CUI:C1527168 Bonnevie-Ullrich syndrome Gonadal dysgenesis - Turner Karyotype 45, X Monosomy X XO syndrome monosomy X syndrome disease_ontology DOID:3491 No OMIM mapping, confirmed by DO. [LS]. Turner syndrome A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen. GARD:7051 ICD10CM:M35.1 MESH:D008947 NCI:C84892 SNOMEDCT_US_2020_03_01:33110008 UMLS_CUI:C0026272 Connective tissue disease overlap syndrome mixed collagen vascular disease disease_ontology DOID:3492 mixed connective tissue disease An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance. MESH:D018279 NCI:C3774 SNOMEDCT_US_2020_03_01:189701002 UMLS_CUI:C0206696 Signet Ring cell adenocarcinoma Signet ring carcinoma Signet ring cell carcinoma disease_ontology DOID:3493 signet ring cell adenocarcinoma A pancreatic adenocarcinoma that derives_from pancreatic duct cells. NCI:C9120 SNOMEDCT_US_2020_03_01:792907004 UMLS_CUI:C1335302 ductal adenocarcinoma of the pancreas disease_ontology DOID:3498 pancreatic ductal adenocarcinoma GARD:6987 ICD10CM:D47.09 MESH:D008415 NCI:C84269 OMIM:154800 SNOMEDCT_US_2020_03_01:78745000 UMLS_CUI:C0024899 mast cell hyperplasia disease_ontology DOID:350 OMIM mapping confirmed by DO. [LS]. mastocytosis A fibrosarcoma that is located_in the dermis laryer of the skin and that begins as a hard nodule and grows slowly. GARD:9569 MESH:D018223 OMIM:607907 SNOMEDCT_US_2020_03_01:302844005 UMLS_CUI:C0206647 disease_ontology DOID:3507 MESH:C538219 added from NeuroDevNet [WAK]. dermatofibrosarcoma protuberans GARD:8211 MESH:D018319 SNOMEDCT_US_2020_03_01:19897006 UMLS_CUI:C0206729 Neurosarcoma disease_ontology DOID:3512 neurofibrosarcoma NCI:C8088 UMLS_CUI:C0279981 disease_ontology DOID:3520 pediatric fibrosarcoma MESH:D020244 UMLS_CUI:C0740392 disease_ontology DOID:3525 middle cerebral artery infarction A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain. ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 SNOMEDCT_US_2020_03_01:195188006 UMLS_CUI:C0007785 CVA - Cerebral infarction Cerebral infarct Cerebral infarction disease_ontology DOID:3526 cerebral infarction MESH:D002539 UMLS_CUI:C0007774 disease_ontology DOID:3527 cerebral arterial disease ICD10CM:G71.2 MESH:D020512 NCI:C83010 OMIM:117000 SNOMEDCT_US_2020_03_01:43152001 UMLS_CUI:C0751951 central core disease disease_ontology DOID:3529 OMIM mapping confirmed by DO. [SN]. central core myopathy MESH:D034081 UMLS_CUI:C1135993 disease_ontology DOID:3530 chronic wasting disease A progressive myoclonus epilepsy characterized by onset between 6 and 13 years of age of action- and stimulus-sensitive myoclonus, tonic-clonic seizures with ataxia, and a mild cognitive decline. GARD:3876 MESH:D020194 SNOMEDCT_US_2020_03_01:192847001 UMLS_CUI:C0751785 Unverricht - Lundborg disease Unverricht's disease Unverricht-Lundborg disease disease_ontology DOID:3535 OMIM mapping confirmed by DO. [LS]. Unverricht-Lundborg syndrome A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain. MESH:D016545 NCI:C3473 SNOMEDCT_US_2020_03_01:254942002 UMLS_CUI:C0085138 tumor of choroid plexus tumor of the Choroid Plexus disease_ontology choroid plexus neoplasm DOID:3540 choroid plexus cancer A cerebrum cancer that is located_in the cerebral ventricles. DOID:10856 GARD:6025 ICD10CM:C71.5 ICD9CM:191.5 MESH:D002551 NCI:C2937 SNOMEDCT_US_2020_03_01:126958000 SNOMEDCT_US_2020_03_01:363471001 UMLS_CUI:C0007798 UMLS_CUI:C0346906 Intraventricular tumor of brain cerebral ventricle neoplasm disease_ontology DOID:3541 cerebral ventricle cancer A sarcoma that has_material_basis in mast cells. ICD10CM:C96.22 ICD9CM:202.6 MESH:D012515 NCI:C9348 SNOMEDCT_US_2020_03_01:118615008 UMLS_CUI:C0036221 disease_ontology DOID:355 mast-cell sarcoma GARD:7712 MESH:D013478 NCI:C85175 SNOMEDCT_US_2020_03_01:24988007 UMLS_CUI:C0038828 Superior mesenteric artery syndrome disease_ontology DOID:3557 superior mesenteric artery syndrome ICD10CM:K31.5 MESH:D004380 NCI:C79548 SNOMEDCT_US_2020_03_01:95532008 UMLS_CUI:C0013292 disease_ontology DOID:3558 duodenal obstruction An appendix cancer that is characterized by progressive accumulation of mucus-secreting tumor cells within the abdomen and pelvis. GARD:7488 MESH:D011553 NCI:C3345 SNOMEDCT_US_2020_03_01:307601000 UMLS_CUI:C0033822 Pseudomyxoma peritonei mucinous Ascites disease_ontology DOID:3559 pseudomyxoma peritonei A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid cap cells of the arachnoid villi in the meninges. DOID:1137 DOID:3554 DOID:3567 DOID:4750 GARD:7015 ICD10CM:D32.9 ICDO:M9530/3 MESH:D008577 MESH:D008579 NCI:C3229 NCI:C3230 NCI:C4656 NCI:C6971 NCI:C7048 SNOMEDCT_US_2020_03_01:127579001 SNOMEDCT_US_2020_03_01:269643009 SNOMEDCT_US_2020_03_01:302820008 UMLS_CUI:C0025284 UMLS_CUI:C0025286 UMLS_CUI:C0349604 UMLS_CUI:C1334698 UMLS_CUI:C1336537 intracranial meningioma meningeal neoplasm meningothelial cell tumor neoplasm of the meninges primary Meningeal tumor supratentorial meningioma disease_ontology DOID:3565 meningioma A hepatobiliary system cancer that is located_in the liver. DOID:12300 DOID:269 DOID:7330 DOID:915 DOID:919 ICD10CM:C22.0 ICD10CM:C22.9 ICD9CM:155.0 ICD9CM:155.2 MESH:D008113 NCI:C34803 NCI:C7692 SNOMEDCT_US_2020_03_01:126851005 SNOMEDCT_US_2020_03_01:187771009 SNOMEDCT_US_2020_03_01:93870000 UMLS_CUI:C0023903 UMLS_CUI:C0024620 UMLS_CUI:C0345904 UMLS_CUI:C0854795 Ca liver - primary Resectable malignant neoplasm of Liver ca liver - primary hepatic cancer hepatic neoplasm malignant hepato-biliary neoplasm malignant neoplasm of liver malignant neoplasm of liver, not specified as primary or secondary malignant neoplasm of liver, primary malignant tumor of liver neoplasm of liver non-resectable primary hepatic malignant neoplasm primary liver cancer primary malignant neoplasm of Liver primary malignant neoplasm of liver resectable malignant neoplasm of the liver disease_ontology DOID:3571 liver cancer MESH:D012851 UMLS_CUI:C0037198 disease_ontology DOID:3572 intracranial sinus thrombosis MESH:D020227 SNOMEDCT_US_2020_03_01:21258007 UMLS_CUI:C0270639 Thrombosis of lateral venous sinus Thrombosis transverse sinus disease_ontology DOID:3574 lateral sinus thrombosis MESH:D020225 SNOMEDCT_US_2020_03_01:70607008 UMLS_CUI:C0338575 Thrombosis of superior longitudinal sinus Thrombosis of superior sagittal sinus disease_ontology DOID:3576 sagittal sinus thrombosis A sex cord-gonadal stromal tumor characterized by excessive proliferation of Sertoli cells. DOID:0050617 MESH:D012707 NCI:C39976 SNOMEDCT_US_2020_03_01:89089007 UMLS_CUI:C0036769 tubular androblastoma disease_ontology DOID:3577 Sertoli cell tumor NCI:C39911 UMLS_CUI:C1515283 disease_ontology DOID:3579 testicular gonadoblastoma DOID:14071 DOID:3598 ICD10CM:O01 ICD9CM:630 MESH:D006828 MESH:D031901 NCI:C3110 NCI:C4699 NCI:C7887 OMIM:231090 SNOMEDCT_US_2020_03_01:156085008 SNOMEDCT_US_2020_03_01:417475006 UMLS_CUI:C0020217 UMLS_CUI:C0278796 UMLS_CUI:C1135868 gestational trophoblastic neoplasia hydatidiform mole molar pregnancy disease_ontology DOID:3590 OMIM mapping confirmed by DO. [SN]. gestational trophoblastic neoplasm NCI:C6900 SNOMEDCT_US_2020_03_01:128767001 UMLS_CUI:C1266159 disease_ontology DOID:3593 epithelioid trophoblastic tumor A placenta cancer that has_material_basis_in trophoblastic cells. GARD:6059 ICD10CM:C58 MESH:D002822 NCI:C2948 SNOMEDCT_US_2020_03_01:189444004 UMLS_CUI:C0008497 Chorioepithelioma disease_ontology DOID:3594 choriocarcinoma A choriocarcinoma that is characterized by low beta-hCG levels and arises from neoplastic transformation of intermediate trophoblastic cells. MESH:D018245 NCI:C3757 SNOMEDCT_US_2020_03_01:75320001 UMLS_CUI:C0206666 Placental site trophoblastic tumor Placental site trophoblastic tumour Placental-Site Gestational Trophoblastic neoplasm placental site trophoblastic tumour disease_ontology DOID:3596 placental site trophoblastic tumor A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems. MESH:D020258 NCI:C27961 SNOMEDCT_US_2020_03_01:19466003 UMLS_CUI:C0235032 neurotoxicity neurotoxicity syndrome disease_ontology DOID:3602 toxic encephalopathy A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells. MESH:D018282 NCI:C3776 SNOMEDCT_US_2020_03_01:79143006 UMLS_CUI:C0206699 Pseudomucinous cystadenocarcinoma disease_ontology DOID:3603 mucinous cystadenocarcinoma An ovarian cystadenocarcinoma that is characterized by the presence of mucin. NCI:C4026 SNOMEDCT_US_2020_03_01:254851009 UMLS_CUI:C0279665 Ovarian mucinous cystadenocarcinoma mucinous cystadenocarcinoma of ovary disease_ontology DOID:3604 ovarian mucinous cystadenocarcinoma An ovary adenocarcinoma that is characterized by the presence of cysts or cystic spaces. NCI:C5228 SNOMEDCT_US_2020_03_01:314191009 UMLS_CUI:C1096638 cystadenocarcinoma of ovary cystadenocarcinoma of the Ovary disease_ontology DOID:3605 ovarian cystadenocarcinoma An ovary adenocarcinoma that is characterized by the presence of mucin. NCI:C5243 UMLS_CUI:C1335167 mucinous carcinoma of Ovary disease_ontology DOID:3606 ovarian mucinous adenocarcinoma An appendix carcinoma that derives_from epithelial cells of glandular origin. NCI:C7718 SNOMEDCT_US_2020_03_01:413445002 UMLS_CUI:C0238003 Appendiceal adenocarcinoma disease_ontology DOID:3608 appendix adenocarcinoma A cervix disease that is characterized by the growth endometrial tissue that is located on the cervix. NCI:C27623 SNOMEDCT_US_2020_03_01:61640006 UMLS_CUI:C0269107 Endometriosis of cervix cervical Endometriosis disease_ontology DOID:361 cervix endometriosis ICD10CM:H30.9 MESH:D012173 NCI:C115993 SNOMEDCT_US_2020_03_01:35426003 UMLS_CUI:C0035333 disease_ontology DOID:3612 retinitis GARD:5984 MESH:D017825 NCI:C84611 OMIM:271900 SNOMEDCT_US_2020_03_01:80544005 UMLS_CUI:C0206307 CANAVAN-VAN BOGAERT-BERTRAND DISEASE Spongy degeneration of central nervous system disease_ontology DOID:3613 OMIM mapping confirmed by DO. [SN]. Canavan disease A hypogonadotropic hypogonadism with a defective sense of smell (anosmia or hyposmia). GARD:10771 ICD10CM:E23.0 MESH:D017436 NCI:C75479 ORDO:478 SNOMEDCT_US_2020_03_01:190559001 UMLS_CUI:C0162809 Hypogonadism with anosmia Kallman syndrome Kallman's syndrome familial hypogonadism with anosmia disease_ontology DOID:3614 Kallmann syndrome A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma. MESH:D018206 NCI:C3733 SNOMEDCT_US_2020_03_01:404057003 UMLS_CUI:C0206632 disease_ontology DOID:3616 angiolipoma MESH:D018206 A nervous system cancer that is located_in the central nervous system. DOID:0060093 DOID:1318 EFO:0000326 ICD10CM:C72.9 MESH:D016543 NCI:C4627 NCI:C9293 SNOMEDCT_US_2020_03_01:126951006 SNOMEDCT_US_2020_03_01:93744007 UMLS_CUI:C0085136 UMLS_CUI:C0348374 CNS neoplasm central nervous system tumor central nervous system tumors malignant neoplasm of central nervous system malignant tumor of CNS neoplasm of central nervous system disease_ontology DOID:3620 central nervous system cancer An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size. DOID:11138 DOID:7682 DOID:7692 DOID:7703 ICD10CM:I71.1 ICD10CM:I71.3 ICD10CM:I71.5 ICD10CM:I71.8 ICD10CM:I71.9 ICD9CM:441.1 ICD9CM:441.3 ICD9CM:441.5 ICD9CM:441.6 MESH:D001014 MESH:D001019 NCI:C26697 NCI:C27046 NCI:C27198 NCI:C27299 SNOMEDCT_US_2020_03_01:14336007 SNOMEDCT_US_2020_03_01:155419006 SNOMEDCT_US_2020_03_01:195265003 SNOMEDCT_US_2020_03_01:34365005 SNOMEDCT_US_2020_03_01:73067008 UMLS_CUI:C0003486 UMLS_CUI:C0265010 UMLS_CUI:C0265012 UMLS_CUI:C0741160 UMLS_CUI:C1305122 ruptured aortic aneurysm disease_ontology DOID:3627 aortic aneurysm MESH:D001014 MESH:D001019 A female reproductive organ cancer that is located_in the uterus. DOID:4363 ICD10CM:C55 ICD9CM:179 MESH:D014594 NCI:C3435 NCI:C3552 SNOMEDCT_US_2020_03_01:126908007 SNOMEDCT_US_2020_03_01:371973000 UMLS_CUI:C0042138 UMLS_CUI:C0153567 CA - cancer of uterus Tumour of uterus malignant neoplasm of uterus malignant uterine tumor neoplasm of uterus uterine tumor uterus neoplasm disease_ontology DOID:363 uterine cancer A lysosomal storage disease that has_material_basis_in deficiency of the beta-A-manosidase enzyme resulting in the disruption of N-linked glycoprotein oligosaccharide catabolism. MESH:D044905 NCI:C84596 OMIM:248510 SNOMEDCT_US_2020_03_01:238047006 UMLS_CUI:C4048196 Beta-D-mannosidosis beta-mannosidase deficiency lysosomal beta-mannosidase deficiency disease_ontology DOID:3633 OMIM mapping confirmed by DO. [SN]. beta-mannosidosis A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic). GARD:11902 MESH:D020294 NCI:C84647 OMIM:PS601462 ORDO:590 SNOMEDCT_US_2020_03_01:230672006 UMLS_CUI:C0751882 disease_ontology DOID:3635 Xref MGI. congenital myasthenic syndrome A teratoma that is located_in the central nervous system. NCI:C5441 UMLS_CUI:C1332895 CNS teratoma disease_ontology DOID:3640 central nervous system teratoma GARD:6331 MESH:D004652 NCI:C84686 SNOMEDCT_US_2020_03_01:393569006 UMLS_CUI:C0014008 Empty sella syndrome disease_ontology DOID:3642 empty sella syndrome MESH:D004652 NCI:C27066 SNOMEDCT_US_2020_03_01:59572000 UMLS_CUI:C0271558 Pituitary necrosis disease_ontology DOID:3646 necrosis of pituitary A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex. GARD:4620 GARD:7513 ICD10CM:E74.4 MESH:D015325 NCI:C103968 OMIM:245348 OMIM:245349 OMIM:312170 OMIM:608782 OMIM:614111 ORDO:79243 SNOMEDCT_US_2020_03_01:46683007 UMLS_CUI:C0034345 deficiency of pyruvic dehydrogenase pyruvate dehydrogenase complex deficiency disease pyruvate dehydrogenase deficiency disease_ontology DOID:3649 Xref MGI. OMIM mapping confirmed by DO. [SN]. pyruvate decarboxylase deficiency A urinary system disease that is located_in the bladder. ICD10CM:N32.9 ICD9CM:596.9 MESH:D001745 NCI:C2900 SNOMEDCT_US_2020_03_01:42643001 UMLS_CUI:C0005686 Urinary Bladder Disease disease_ontology DOID:365 bladder disease A metabolic acidosis characterized by buildup of lactate. ICD10CM:E87.2 MESH:D000140 NCI:C98969 SNOMEDCT_US_2020_03_01:91273001 UMLS_CUI:C0001125 disease_ontology DOID:3650 lactic acidosis A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. GARD:6877 ICD10CM:G31.82 MESH:D007888 NCI:C84814 OMIM:256000 ORDO:506 SNOMEDCT_US_2020_03_01:29570005 UMLS_CUI:C0023264 Infantile necrotizing encephalomyelopathy Leigh syndrome juvenile subacute necrotizing encephalomyelopathy disease_ontology subacute necrotizing encephalomyelopathy DOID:3652 Xref MGI. OMIM mapping confirmed by DO. [SN]. Leigh disease A lysosomal storage disease characterized by increased sialic acid in the urine. MESH:D029461 NCI:C85067 OMIM:269921 OMIM:604369 SNOMEDCT_US_2020_03_01:238051008 UMLS_CUI:C0342853 disease_ontology DOID:3659 OMIM mapping confirmed by DO. [LS]. OMIM mapping submitted by NeuroDevNet. [LS]. sialuria NCI:C5121 SNOMEDCT_US_2020_03_01:126967000 UMLS_CUI:C0346319 neoplasm of olfactory nerve tumor of Olfactory nerve disease_ontology DOID:366 olfactory nerve neoplasm A hematologic cancer that has_material_basis_in mast cells. ICD10CM:D47.09 NCI:C9295 SNOMEDCT_US_2020_03_01:127581004 UMLS_CUI:C0334664 Mast cell Proliferative disease mast cell tumor mastocytoma disease_ontology DOID:3664 mast cell neoplasm ICD10CM:I73.9 MESH:D007383 SNOMEDCT_US_2020_03_01:195312007 UMLS_CUI:C0021775 Charcot's syndrome Intermittent claudication disease_ontology DOID:3669 intermittent claudication A childhood kidney neoplasm that is located_in the kidney, liver, muscle, heart, lung, soft tissues, skin and central nervous system. GARD:7572 MESH:D018335 NCI:C3808 SNOMEDCT_US_2020_03_01:83118000 UMLS_CUI:C0206743 Rhabdoid sarcoma malignant rhabdoid tumour disease_ontology rhabdoid tumor DOID:3672 rhabdoid cancer MESH:D018335 NCI:C6563 UMLS_CUI:C1333003 pediatric renal tumor disease_ontology DOID:3675 childhood kidney cancer A supratentorial cancer that is located_in the cerebrum. DOID:912 ICD9CM:191.8 NCI:C4874 SNOMEDCT_US_2020_03_01:126953009 SNOMEDCT_US_2020_03_01:188300006 UMLS_CUI:C0153642 UMLS_CUI:C1263885 cerebral cancer neoplasm of cerebrum tumor of Cerebrum disease_ontology DOID:368 cerebrum cancer MESH:D008175 NCI:C3200 SNOMEDCT_US_2020_03_01:126713003 UMLS_CUI:C0024121 tumor of the lung disease_ontology DOID:3683 lung benign neoplasm A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, has_symptom myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and severe headaches, and develops_from mutation in mitochondrial genes including MT-TL1, which encodes tRNA proteins. ICD10CM:E88.41 MESH:D017241 NCI:C84885 OMIM:540000 SNOMEDCT_US_2020_03_01:39925003 UMLS_CUI:C0162671 MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES disease_ontology DOID:3687 OMIM mapping confirmed by DO. [SN]. MELAS syndrome ICD10CM:G54.5 MESH:D020968 NCI:C84600 SNOMEDCT_US_2020_03_01:26609002 UMLS_CUI:C0221759 Brachial neuritis Parsonage-Aldren-Turner syndrome disease_ontology DOID:3689 brachial plexus neuritis GARD:2197 MESH:D018304 NCI:C3789 SNOMEDCT_US_2020_03_01:76060004 UMLS_CUI:C0206717 Asthesioneuroblastoma Esthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma paranasal sinus Olfactory neuroblastoma disease_ontology DOID:369 olfactory neuroblastoma ICD10CM:G54.0 MESH:D020516 NCI:C27194 SNOMEDCT_US_2020_03_01:3548001 UMLS_CUI:C0700251 Brachial plexus disorder brachial plexopathy disease_ontology DOID:3690 brachial plexus neuropathy An integumentary system disease that is located_in skin. DOID:1576 DOID:1698 DOID:187 DOID:6486 DOID:8948 ICD9CM:702 MESH:D012871 MESH:D012873 NCI:C156032 NCI:C3371 SNOMEDCT_US_2020_03_01:201095006 SNOMEDCT_US_2020_03_01:5613003 SNOMEDCT_US_2020_03_01:95320005 UMLS_CUI:C0029574 UMLS_CUI:C0037274 UMLS_CUI:C0037277 Genodermatosis skin and subcutaneous tissue disease disease_ontology DOID:37 skin disease A fallopian tube carcinoma that derives_from epithelial cells of glandular origin. NCI:C6265 UMLS_CUI:C1333590 adenocarcinoma of the fallopian tube disease_ontology DOID:3706 fallopian tube adenocarcinoma A bladder carcinoma that derives_from epithelial cells of glandular origin. NCI:C4032 SNOMEDCT_US_2020_03_01:255110003 UMLS_CUI:C0279682 adenocarcinoma of bladder adenocarcinoma of the urinary bladder bladder adenocarcinoma, Not Otherwise Specified disease_ontology DOID:3711 bladder adenocarcinoma An ovarian carcinoma that derives_from epithelial cells of glandular origin. DOID:7816 NCI:C7700 UMLS_CUI:C0948216 Ovarian adenocarcinoma ovarian adenoacanthoma disease_ontology adenocarcinoma of the ovary DOID:3713 ovary adenocarcinoma A stomach carcinoma that derives_from epithelial cells of glandular origin. NCI:C4004 SNOMEDCT_US_2020_03_01:408647009 UMLS_CUI:C0278701 adenocarcinoma of stomach stomach adenocarcinoma disease_ontology DOID:3717 gastric adenocarcinoma ICD10CM:C90.3 MESH:D010954 NCI:C9349 SNOMEDCT_US_2020_03_01:302852008 UMLS_CUI:C0032131 Myeloma - solitary Myeloma, solitary Solitary myeloma Solitary plasmacytoma disease_ontology DOID:3721 plasmacytoma A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks. MESH:D013801 SNOMEDCT_US_2020_03_01:68771000 UMLS_CUI:C0039753 Infection by Theileria theileriosis disease_ontology DOID:3733 theileriasis A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium. MESH:D018289 NCI:C3781 SNOMEDCT_US_2020_03_01:89906000 UMLS_CUI:C0206706 Warty carcinoma verrucous squamous carcinoma verrucous squamous cell carcinoma disease_ontology DOID:3737 verrucous carcinoma An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods. MESH:D009748 NCI:C26836 SNOMEDCT_US_2020_03_01:191077005 UMLS_CUI:C3714509 Nutritional disorder disease_ontology DOID:374 nutrition disease A cervix carcinoma that has_material_basis_in squamous cells of the cervix. NCI:C4028 SNOMEDCT_US_2020_03_01:254886006 UMLS_CUI:C0279671 squamous cell carcinoma of cervix squamous cell carcinoma of the Cervix Uteri disease_ontology DOID:3744 cervical squamous cell carcinoma An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus. MESH:D000077277 NCI:C4024 SNOMEDCT_US_2020_03_01:276804009 UMLS_CUI:C0279626 SCC of esophagus SCC of oesophagus oesophagus squamous cell carcinoma disease_ontology DOID:3748 OMIM mapping confirmed by DO. [SN]. esophagus squamous cell carcinoma NCI:C8188 UMLS_CUI:C0280328 verrucous carcinoma of the Larynx disease_ontology DOID:3752 larynx verrucous carcinoma A syndrome characterized by oculocutaneous albinism, bleeding problems due to platelet storage pool defect, visual impairment and lysosomal accumulation of ceroid lipofuscin. GARD:6643 ICD10CM:E70.331 MESH:D022861 NCI:C37261 OMIM:PS203300 ORDO:231531 ORDO:231537 ORDO:280663 ORDO:79430 SNOMEDCT_US_2020_03_01:60255003 UMLS_CUI:C0079504 disease_ontology DOID:3753 Xref MGI. OMIM mapping confirmed by DO. [SN]. Hermansky-Pudlak syndrome A thrombophilia that is characterized by the tendency to form clots in the veins. ICD10CM:D68.59 MESH:D020152 NCI:C98815 OMIM:613118 SNOMEDCT_US_2020_03_01:36351005 UMLS_CUI:C0272375 AT III deficiency hereditary thrombophilia due to congenital antithrombin deficiency disease_ontology DOID:3755 Xref MGI. antithrombin III deficiency A thrombophilia that is characterized by recurrent venous thrombosis and that has_material_basis_in heterozygous mutation in the PROC gene on chromosome 2q14. GARD:4521 ICD10CM:D68.59 MESH:D020151 NCI:C99025 ORDO:745 SNOMEDCT_US_2020_03_01:76407009 UMLS_CUI:C0398625 disease_ontology DOID:3756 protein C deficiency MESH:D012734 NCI:C45909 SNOMEDCT_US_2020_03_01:52572004 UMLS_CUI:C0019269 disease_ontology DOID:3763 hermaphroditism A syndrome that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene). GARD:5576 MESH:D030321 NCI:C84668 OMIM:194080 SNOMEDCT_US_2020_03_01:236385009 UMLS_CUI:C0950121 disease_ontology DOID:3764 OMIM mapping confirmed by DO. [SN]. Denys-Drash syndrome DOID:11226 ICD10CM:Q56 ICD10CM:Q56.3 ICD9CM:752.7 MESH:D012734 NCI:C124575 SNOMEDCT_US_2020_03_01:204895009 SNOMEDCT_US_2020_03_01:268328009 UMLS_CUI:C0021193 UMLS_CUI:C0033804 Indeterminate sex and pseudohermaphroditism disease_ontology DOID:3765 pseudohermaphroditism A vaginal discharge that is characterized by a whitish or yellow color. ICD10CM:N89.8 MESH:D007973 NCI:C34775 SNOMEDCT_US_2020_03_01:156017008 UMLS_CUI:C0023533 Leukorrhea of vagina discharge - leukorrhea disease_ontology DOID:3766 leukorrhea A vaginal disease that is characterized by the presence of discharge. MESH:D019522 NCI:C50795 SNOMEDCT_US_2020_03_01:70856007 UMLS_CUI:C0227791 disease_ontology DOID:3767 vaginal discharge An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. MESH:D011658 NCI:C26869 SNOMEDCT_US_2020_03_01:155613001 UMLS_CUI:C0034069 Fibrosis of lung disease_ontology DOID:3770 pulmonary fibrosis NCI:C5592 SNOMEDCT_US_2020_03_01:128789002 UMLS_CUI:C1322252 Chordoid glioma disease_ontology DOID:3774 chordoid glioma An ovarian disease that is characterized by the absence of ovulation. MESH:D000858 NCI:C34388 SNOMEDCT_US_2020_03_01:34571000 UMLS_CUI:C0003128 disease_ontology DOID:3781 anovulation A syndrome that is characterized by skeletal malformations, growth retardation, hearing deficit, paroxysmal movement disorders, and cognitive impairment in affected males and some carrier females, and has_material_basis_in mutation in the RSK2 gene on chromosome Xp22. GARD:6123 MESH:D038921 NCI:C84643 OMIM:303600 SNOMEDCT_US_2020_03_01:15182000 UMLS_CUI:C0265252 disease_ontology DOID:3783 OMIM mapping confirmed by DO. [SN]. Coffin-Lowry syndrome DOID:13122 DOID:835 ICD10CM:H61.9 ICD9CM:380 NCI:C26972 SNOMEDCT_US_2020_03_01:49130001 UMLS_CUI:C0155388 Preauricular cyst Preauricular sinus and fistula Preauricular sinus or fistula disease_ontology DOID:379 external ear disease A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath. DOID:11023 DOID:13630 DOID:14304 ICD10CM:J86 MESH:D016724 NCI:C45692 SNOMEDCT_US_2020_03_01:196069007 UMLS_CUI:C0014013 Empyema Empyema of pleura Empyema of pleura without fistula Empyema with fistula Empyema with no fistula Empyema with pleural fistula Empyema without mention of fistula Empyema, chest Pleural empyema with fistula Purulent pleurisy Thorax abscess abscess of pleural cavity abscess of thorax empyema empyema with fistula lung empyema pleural empyema with no fistula purulent pleuritis pyothorax disease_ontology DOID:3798 Updating outdated UMLS CUI. pleural empyema A bone disease that is located_in the joint. DOID:13871 DOID:13960 DOID:1843 DOID:1903 DOID:226 DOID:2317 DOID:2318 DOID:546 DOID:9489 ICD10CM:M00-M02 ICD10CM:M12.9 ICD9CM:711 ICD9CM:719.90 MESH:D007592 NCI:C35760 NCI:C78402 SNOMEDCT_US_2020_03_01:48548006 SNOMEDCT_US_2020_03_01:8316001 UMLS_CUI:C0022408 UMLS_CUI:C0157749 Ankylosis of joint of ankle and/or foot Ankylosis of joint of forearm Ankylosis of joint of hand Ankylosis of joint of lower leg Ankylosis of joint of multiple sites Ankylosis of joint of shoulder region Ankylosis of joint of upper arm Ankylosis of multiple joints Infectious arthropathy Joint ankylosis of the ankle and foot Joint ankylosis of the ankle and/or foot Joint ankylosis of the forearm Joint ankylosis of the hand Joint ankylosis of the lower leg Joint ankylosis of the pelvic region and thigh Joint ankylosis of the shoulder region Joint ankylosis of the upper arm ankylosis of ankle and foot joint ankylosis of forearm joint ankylosis of hand joint ankylosis of joint of multiple sites ankylosis of joint of pelvic region and thigh ankylosis of joint of shoulder region ankylosis of lower leg joint ankylosis of upper arm joint disease_ontology DOID:381 arthropathy An allergic contact dermatitis that is characterized by a delayed-type hypersensitivity cutaneous reaction in response to a photoantigen applied to the skin in individuals previously sensitized to the same substance, and has_symptom erythematous papules, vesicles, or eczema. MESH:D017454 SNOMEDCT_US_2020_03_01:111209006 UMLS_CUI:C0162824 Photoallergic contact dermatitis Photoallergic dermatitis Photoallergic eczema disease_ontology DOID:3818 photoallergic dermatitis A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. GARD:1481 ICD10CM:K44 MESH:D006548 NCI:C34687 OMIM:142340 OMIM:222400 OMIM:610187 ORDO:2140 SNOMEDCT_US_2020_03_01:155748004 UMLS_CUI:C0019284 Diaphragmatic Hernia disease_ontology DOID:3827 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital diaphragmatic hernia ICD10CM:Q79.0 A pituitary gland benign neoplasm that derives_from glandular epithelial cells. MESH:D010911 NCI:C3329 OMIM:PS102200 SNOMEDCT_US_2020_03_01:154621002 UMLS_CUI:C0032000 adenoma of the Pituitary gland disease_ontology DOID:3829 pituitary adenoma DOID:10392 GARD:7897 ICD10CM:I45.6 ICD9CM:426.7 MESH:D014927 NCI:C35132 OMIM:194200 SNOMEDCT_US_2020_03_01:195057009 SNOMEDCT_US_2020_03_01:74390002 UMLS_CUI:C0043202 UMLS_CUI:C0392470 Anomalous A-V excitation Wolff-Parkinson-White pattern anomalous atrioventricular excitation disease_ontology DOID:384 OMIM mapping confirmed by DO. [LS]. OMIM mapping confirmed by DO. [SN]. Wolff-Parkinson-White syndrome GARD:10486 MESH:D003397 NCI:C2964 SNOMEDCT_US_2020_03_01:189179009 UMLS_CUI:C0010276 neoplasm of Rathke's Pouch disease_ontology DOID:3840 craniopharyngioma MESH:D019292 NCI:C4676 UMLS_CUI:C0376527 tumors of Skull Base disease_ontology DOID:3842 skull base cancer DOID:6097 NCI:C5125 NCI:C5126 UMLS_CUI:C1333286 UMLS_CUI:C1334576 malignant Diencephalic tumor malignant diencephalic neoplasm tumor of Diencephalon disease_ontology DOID:3843 diencephalic neoplasm DOID:4133 DOID:4134 DOID:6252 DOID:6253 GARD:7378 ICD10CM:Q85.8 MESH:D010580 NCI:C3324 NCI:C4733 NCI:C7755 OMIM:175200 ORDO:2869 SNOMEDCT_US_2020_03_01:157029009 SNOMEDCT_US_2020_03_01:277161008 SNOMEDCT_US_2020_03_01:53633000 UMLS_CUI:C0031269 UMLS_CUI:C0265323 UMLS_CUI:C0456487 Colonic hamartomatous polyp Peutz Jeghers colon polyp Peutz Jeghers polyp Peutz-Jeghers polyp of small Intestine gastric Peutz-Jeghers polyp peutz-jeghers small bowel hamartoma disease_ontology DOID:3852 OMIM mapping confirmed by DO. [SN]. Peutz-Jeghers syndrome NCI:C39908 SNOMEDCT_US_2020_03_01:236740006 UMLS_CUI:C0341767 Seminal Vesicle neoplasm seminal vesicle tumour tumor of seminal vesicle tumour of seminal vesicle disease_ontology DOID:3855 seminal vesicle tumor A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum. DOID:10284 ICD10CM:C63.9 ICD9CM:187.9 MESH:D005834 NCI:C3054 NCI:C8561 SNOMEDCT_US_2020_03_01:126895004 SNOMEDCT_US_2020_03_01:363515000 UMLS_CUI:C0017417 UMLS_CUI:C0153606 male genital cancer male reproductive system neoplasm malignant neoplasm of male genital organ malignant neoplasm of male genital organ or tract malignant neoplasm of male genital organs malignant tumor of male Reproductive system malignant tumor of male genital organ neoplasm of male genital organ tumor of male Reproductive system disease_ontology male genital neoplasm DOID:3856 male reproductive organ cancer A medulloblastoma that is characterized by cells that are larger than would be normally expected. NCI:C6904 SNOMEDCT_US_2020_03_01:128790006 UMLS_CUI:C1266180 large cell Medulloblastoma disease_ontology DOID:3857 large cell medulloblastoma MESH:D008527 NCI:C3706 SNOMEDCT_US_2020_03_01:24604009 UMLS_CUI:C0205833 Medullomyoblastoma disease_ontology DOID:3861 medullomyoblastoma DOID:6380 MESH:D008527 NCI:C4011 NCI:C9373 UMLS_CUI:C0278876 UMLS_CUI:C1332188 adult brain medulloblastoma disease_ontology DOID:3864 adult medulloblastoma MESH:D008527 NCI:C3997 UMLS_CUI:C0278510 pediatric Medulloblastoma disease_ontology DOID:3869 childhood medulloblastoma MESH:D003109 UMLS_CUI:C0009374 disease_ontology DOID:3877 functional colonic disease A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers. DOID:0050586 DOID:3040 GARD:9905 MESH:D003123 NCI:C120083 OMIM:PS120435 ORDO:144 SNOMEDCT_US_2020_03_01:315058005 UMLS_CUI:C0009405 UMLS_CUI:C1333990 COCA 1 HNPCC - hereditary nonpolyposis colon cancer Hereditary Defective Mismatch Repair syndrome hereditary nonpolyposis colorectal cancer hereditary nonpolyposis colorectal neoplasm disease_ontology DOID:3883 OMIM mapping confirmed by DO. [SN]. Lynch syndrome GARD:5732 MESH:D017118 NCI:C84536 OMIM:176000 SNOMEDCT_US_2020_03_01:190914003 UMLS_CUI:C0162565 AIP - acute intermittent porphyria Pyrroloporphyria porphyria intermittent acute disease_ontology DOID:3890 acute intermittent porphyria A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy. MESH:D010927 SNOMEDCT_US_2020_03_01:156185006 UMLS_CUI:C0032051 disease_ontology DOID:3891 placental insufficiency A pancreatic cystadenoma that is characterized by the overproduction of insulin. DOID:3903 GARD:3010 MESH:D007340 MESH:D007516 NCI:C65184 NCI:C95598 SNOMEDCT_US_2020_03_01:189586007 SNOMEDCT_US_2020_03_01:25324008 UMLS_CUI:C0021670 UMLS_CUI:C0022134 Insulin-Producing tumor of Islet cells Islet cell adenoma disease_ontology DOID:3892 insulinoma MESH:D018251 NCI:C3760 SNOMEDCT_US_2020_03_01:80549000 UMLS_CUI:C0206672 Apocrine Cystadenoma Apocrine cystadenoma Eccrine Cystadenoma Eccrine hidrocystoma of skin Hidrocystoma disease_ontology DOID:3893 hidrocystoma MESH:D018251 NCI:C4168 SNOMEDCT_US_2020_03_01:307596009 UMLS_CUI:C0334345 tubular Apocrine adenoma disease_ontology DOID:3895 apocrine adenoma A sweat gland benign neoplasm that is located_in an apical sweat gland. MESH:D006607 NCI:C7560 SNOMEDCT_US_2020_03_01:81393009 UMLS_CUI:C0019522 Hidradenoma of skin Sweat gland adenoma Syringoadenoma disease_ontology DOID:3896 hidradenoma A vulvar disease that is characterized by inflammation of the vulva. ICD10CM:N76.2 MESH:D014847 SNOMEDCT_US_2020_03_01:63144007 UMLS_CUI:C0042996 disease_ontology DOID:3901 vulvitis A bronchus cancer that has_material_basis_in epithelial cells. MESH:D002283 NCI:C35875 SNOMEDCT_US_2020_03_01:254622008 UMLS_CUI:C0007121 BC - Bronchogenic carcinoma disease_ontology DOID:3904 bronchus carcinoma A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis. EFO:0001071 NCI:C4878 SNOMEDCT_US_2020_03_01:154485001 UMLS_CUI:C0684249 cancer of lung disease_ontology carcinoma of lung DOID:3905 OMIM mapping confirmed by DO. [SN]. lung carcinoma MESH:D001984 SNOMEDCT_US_2020_03_01:126705004 UMLS_CUI:C0006264 bronchus neoplasm neoplasm of bronchus disease_ontology DOID:3906 bronchial benign neoplasm A non-small cell lung carcinoma that has_material_basis_in the squamous cell. NCI:C3493 SNOMEDCT_US_2020_03_01:254634000 UMLS_CUI:C0149782 Epidermoid cell carcinoma of the lung disease_ontology squamous cell carcinoma of lung DOID:3907 lung squamous cell carcinoma A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 SNOMEDCT_US_2020_03_01:254637007 UMLS_CUI:C0007131 NSCLC Non-small cell lung cancer non-small cell lung carcinoma disease_ontology DOID:3908 lung non-small cell carcinoma A syndrome characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble aged persons that has_material_basis_in mutation in LMNA on chromosome 1q22. GARD:7467 ICD10CM:E34.8 MEDDRA:10036794 MESH:D011371 NCI:C34951 OMIM:176670 ORDO:740 SNOMEDCT_US_2020_03_01:190590004 UMLS_CUI:C0033300 HGPS Hutchinson Gilford syndrome Hutchinson-Gilford Progeria syndrome Hutchinson-Gilford disease disease_ontology DOID:3911 OMIM mapping confirmed by DO. [SN]. progeria NCI:C4374 SNOMEDCT_US_2020_03_01:235967003 UMLS_CUI:C0341486 disease_ontology DOID:3918 pancreatic cystadenoma NCI:C6504 UMLS_CUI:C1333298 disease_ontology DOID:3923 diffuse lipomatosis GARD:7350 MESH:C535549 NCI:C27486 SNOMEDCT_US_2020_03_01:190802005 UMLS_CUI:C0406608 disease_ontology DOID:3927 pelvic lipomatosis An inner ear disease which involves inflammation of the inner ear. NCI:C27339 UMLS_CUI:C1168225 inner ear infection disease_ontology DOID:3930 otitis interna NCI:C4501 SNOMEDCT_US_2020_03_01:254828009 UMLS_CUI:C0346117 malignant lipomatous tumor malignant tumor of Adipose tissue disease_ontology DOID:3939 lipomatous cancer ICD10CM:E24.0 MESH:D047748 NCI:C113210 SNOMEDCT_US_2020_03_01:190502001 UMLS_CUI:C0221406 Overproduction of ACTH pituitary-dependent Cushing disease disease_ontology DOID:3946 pituitary-dependent Cushing's disease MESH:D000308 NCI:C113208 SNOMEDCT_US_2020_03_01:47270006 UMLS_CUI:C0001622 Adrenocortical hyperfunction hyperadrenalism hypercortisolism disease_ontology DOID:3947 adrenal gland hyperfunction An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. GARD:558 MESH:D018268 NCI:C9325 OMIM:202300 SNOMEDCT_US_2020_03_01:255035007 UMLS_CUI:C0206686 Adrenal cortical carcinoma carcinoma of the Adrenal cortex disease_ontology DOID:3948 adrenocortical carcinoma MESH:D018268 An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. carcinoma of the Adrenal gland disease_ontology DOID:3950 adrenal carcinoma ICD10CM:I40 ICD9CM:422 NCI:C35206 SNOMEDCT_US_2020_03_01:155336004 UMLS_CUI:C0155686 disease_ontology DOID:3951 acute myocarditis MESH:D000303 SNOMEDCT_US_2020_03_01:129636003 UMLS_CUI:C0001614 disease_ontology DOID:3952 adrenal cortex disease An endocrine gland cancer located_in the adrenal glands which are located above the kidneys. DOID:11007 GARD:5751 ICD10CM:C74 ICD9CM:194.0 MESH:D000310 NCI:C2859 NCI:C9338 SNOMEDCT_US_2020_03_01:127021009 SNOMEDCT_US_2020_03_01:93665005 UMLS_CUI:C0001624 UMLS_CUI:C0750887 adrenal cancer adrenal neoplasm malignant Adrenal tumor malignant neoplasm of adrenal gland neoplasm of adrenal gland tumor of the Adrenal gland disease_ontology DOID:3953 adrenal gland cancer A thyroid gland cancer that has_material_basis_in epithelial cells. EFO:0002892 MESH:D013964 NCI:C4815 UMLS_CUI:C0549473 head and neck cancer, Thyroid thyroid gland carcinoma disease_ontology DOID:3963 thyroid gland carcinoma GARD:9266 NCI:C4068 SNOMEDCT_US_2020_03_01:29792007 UMLS_CUI:C0302182 Trabecular adenocarcinoma trabecular carcinoma disease_ontology DOID:3965 Merkel cell carcinoma A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer abd arises from the follicular cells of the thyroid gland. GARD:12027 MESH:D000077273 NCI:C4035 OMIM:188550 SNOMEDCT_US_2020_03_01:255029007 UMLS_CUI:C0238463 Papillary carcinoma of the Thyroid gland disease_ontology DOID:3969 OMIM mapping confirmed by DO. [SN]. thyroid gland papillary carcinoma An intrinsic cardiomyopathy characterized by impaired ventricular filling, with normal or decreased diastolic volume of either or both ventricles typically resulting from increased stiffness of the myocardium. ICD10CM:I42.5 MESH:D002313 NCI:C62798 OMIM:115210 OMIM:PS115210 ORDO:75249 SNOMEDCT_US_2020_03_01:389996009 UMLS_CUI:C0007196 Cardiomyopathy, constrictive Restrictive cardiomyopathy primary restrictive cardiomyopathy disease_ontology Familial restrictive cardiomyopathy Familial restrictive cardiomyopathy DOID:397 Xref MGI. OMIM mappings 115210, 612422 added from NeuroDevNet [WAK]. restrictive cardiomyopathy A thyroid gland carcinoma that has_material_basis_in parafollicular cells. MESH:C536914 NCI:C3879 SNOMEDCT_US_2020_03_01:255032005 UMLS_CUI:C0238462 Medullary carcinoma of the Thyroid gland Medullary thyroid carcinoma Ultimobranchial thyroid tumor Ultimobranchial thyroid tumour medullary thyroid carcinoma disease_ontology DOID:3973 thyroid gland medullary carcinoma A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium. ICD9CM:425.8 SNOMEDCT_US_2020_03_01:195580005 UMLS_CUI:C0155699 disease_ontology DOID:3978 extrinsic cardiomyopathy A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PANK2 gene on chromosome 20p13. GARD:6564 ICD10CM:G23.0 MESH:D006211 NCI:C8967 OMIM:234200 ORDO:157850 SNOMEDCT_US_2020_03_01:2992000 UMLS_CUI:C0018523 Hallervorden-Spatz disease Hallervorden-Spatz syndrome NBIA1 Pigmentary pallidal degeneration brain Iron Accumulation type I syndrome neurodegeneration with brain iron accumulation 1 disease_ontology DOID:3981 OMIM mapping confirmed by DO. [SN]. pantothenate kinase-associated neurodegeneration A cranio-facial dystonia that is accompanied by blepharospasm. GARD:7008 MESH:D008538 SNOMEDCT_US_2020_03_01:230325003 UMLS_CUI:C0025183 disease_ontology DOID:3982 Meige syndrome A trichostrongyloidiasis that involves parasitic infection of the ruminant gastrointestinal tract by nematodes of the genus Ostertagia. MESH:D010029 UMLS_CUI:C0029471 disease_ontology DOID:3985 ostertagiasis A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes. DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 GARD:7827 MESH:D014375 SNOMEDCT_US_2020_03_01:15202009 UMLS_CUI:C0041295 disease_ontology DOID:399 tuberculosis MESH:D014376 An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra. ICD10CM:C68.9 ICD9CM:189.9 SNOMEDCT_US_2020_03_01:448233000 UMLS_CUI:C0348371 disease_ontology DOID:3996 urinary system cancer A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. MESH:D004194 NCI:C2991 SNOMEDCT_US_2020_03_01:64572001 UMLS_CUI:C0012634 disease_ontology DOID:4 disease An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary. EFO:0001075 UMLS_CUI:C0677886 Ovarian carcinoma disease_ontology DOID:4001 OMIM mapping confirmed by DO. [SN]. ovarian carcinoma A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder. NCI:C39851 SNOMEDCT_US_2020_03_01:393562002 UMLS_CUI:C0279680 bladder transitional cell carcinoma transitional cell carcinoma of bladder urinary bladder urothelial carcinoma urothelial bladder carcinoma disease_ontology DOID:4006 bladder urothelial carcinoma A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. EFO:0000292 NCI:C4912 SNOMEDCT_US_2020_03_01:269607003 UMLS_CUI:C0699885 carcinoma of urinary bladder disease_ontology DOID:4007 bladder carcinoma A tuberculosis that is resistant to isoniazid and rifampicin, the two most powerful first-line anti-TB drugs. MESH:D018088 NCI:C128415 SNOMEDCT_US_2020_03_01:423092005 UMLS_CUI:C0206526 disease_ontology DOID:401 multidrug-resistant tuberculosis A transitional cell carcinoma that has several papillary fronds with central fibrovascular core lined by transitional type epithelium. NCI:C4122 SNOMEDCT_US_2020_03_01:12400006 UMLS_CUI:C0334274 Papillary transitional cell carcinoma disease_ontology DOID:4012 papillary transitional carcinoma A ureteral disease that is characterized_as a congenital anomaly in which the distal end of the ureter swells as it enters the bladder. MESH:D014518 NCI:C123159 OMIM:191650 SNOMEDCT_US_2020_03_01:12818004 UMLS_CUI:C0041960 disease_ontology DOID:4022 OMIM mapping confirmed by DO. [LS]. ureterocele A skin hemangioma that is characterized by the presence of small red dots that cluster together to form a linear or snake-like array or ring-shaped pattern located_in the blood vessels of the skin. ICD10CM:L81.7 NCI:C3926 OMIM:106050 OMIM:300652 ORDO:95429 SNOMEDCT_US_2020_03_01:49465005 UMLS_CUI:C0263637 Angioma serpiginosum of skin disease_ontology DOID:4028 Xref MGI. angioma serpiginosum A stomach disease that is an inflammation of the lining of the stomach. DOID:4032 DOID:8697 DOID:8845 DOID:9190 ICD10CM:K29.7 MESH:D005756 NCI:C26780 SNOMEDCT_US_2020_03_01:155711008 UMLS_CUI:C0017152 Erosive Gastritis Erosive gastropathy acute gastric mucosal erosion disease_ontology DOID:4029 gastritis A gastrointestinal system disease that is located_in the mouth. MESH:D009059 NCI:C27641 SNOMEDCT_US_2020_03_01:118938008 UMLS_CUI:C0026636 disease_ontology DOID:403 mouth disease ICD9CM:558.41 NCI:C35330 SNOMEDCT_US_2020_03_01:359804008 UMLS_CUI:C1262481 Eosinophilic Gastroenteritis Eosinophilic gastroenteritis disease_ontology DOID:4031 eosinophilic gastroenteritis NCI:C27051 SNOMEDCT_US_2020_03_01:235658000 UMLS_CUI:C1283271 disease_ontology DOID:4035 lymphocytic gastritis An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting. DOID:9802 MESH:D014385 SNOMEDCT_US_2020_03_01:154286002 UMLS_CUI:C0041312 Tuberculosis of gastrointestinal tract Tuberculosis of intestines, peritoneum and mesenteric glands Tuberculosis of intestines, peritoneum, and mesenteric glands tuberculosis of intestines, peritoneum and mesenteric glands disease_ontology DOID:404 gastrointestinal tuberculosis NCI:C6516 UMLS_CUI:C1334619 malignant tumor of Skeletal Muscle disease_ontology DOID:4043 skeletal muscle cancer NCI:C6514 SNOMEDCT_US_2020_03_01:699955004 UMLS_CUI:C1335971 tumor of Skeletal Muscle disease_ontology DOID:4044 skeletal muscle neoplasm A musculoskeletal system cancer that is located_in muscle. DOID:4046 ICD10CM:C49 MESH:D009217 MESH:D019042 NCI:C4883 SNOMEDCT_US_2020_03_01:20667008 SNOMEDCT_US_2020_03_01:93913006 UMLS_CUI:C0027095 UMLS_CUI:C0684743 malignant neoplasm of muscle malignant tumor of muscle malignant tumor of the Muscle myosarcoma disease_ontology DOID:4045 muscle cancer DOID:4382 GARD:4701 MESH:D018232 NCI:C3749 NCI:C7958 OMIM:268220 SNOMEDCT_US_2020_03_01:404053004 UMLS_CUI:C0206655 UMLS_CUI:C0279613 Alveolar rhabdomyosarcoma alveolar childhood rhabdomyosarcoma disease_ontology DOID:4051 OMIM mapping confirmed by DO. [SN]. alveolar rhabdomyosarcoma A prostate cancer that is located_in the prostate. NCI:C7731 UMLS_CUI:C0238393 sarcoma of the prostate disease_ontology DOID:4054 prostate sarcoma NCI:C4716 SNOMEDCT_US_2020_03_01:128750008 UMLS_CUI:C0431111 Rhabdomyosarcoma with ganglionic differentiation disease_ontology DOID:4055 ectomesenchymoma MESH:D004383 SNOMEDCT_US_2020_03_01:9733003 UMLS_CUI:C0013299 Duodenogastric reflux disease_ontology DOID:4071 duodenogastric reflux MESH:D004378 SNOMEDCT_US_2020_03_01:196598004 UMLS_CUI:C0013289 duodenal disease duodenum disorder disease_ontology DOID:4072 duodenum disease NCI:C3874 SNOMEDCT_US_2020_03_01:235966007 UMLS_CUI:C0238337 cystadenocarcinoma of pancreas disease_ontology DOID:4073 pancreatic cystadenocarcinoma A pancreatic carcinoma that derives_from epithelial cells of glandular origin. NCI:C8294 SNOMEDCT_US_2020_03_01:700423003 UMLS_CUI:C0281361 pancreas adenocarcinoma disease_ontology adenocarcinoma of the pancreas DOID:4074 pancreatic adenocarcinoma A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. MESH:D014264 NCI:C50783 SNOMEDCT_US_2020_03_01:49915006 UMLS_CUI:C0040963 Tricuspid stenosis disease_ontology DOID:4078 tricuspid valve stenosis A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). DOID:989 MESH:D006349 MESH:D016127 NCI:C45525 SNOMEDCT_US_2020_03_01:368009 SNOMEDCT_US_2020_03_01:398995000 UMLS_CUI:C0018824 UMLS_CUI:C0079485 Valvular heart disease disease_ontology DOID:4079 heart valve disease A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal. MESH:D014262 NCI:C50842 SNOMEDCT_US_2020_03_01:111287006 UMLS_CUI:C0040961 Tricuspid incompetence Tricuspid regurgitation Tricuspid valve regurgitation disease_ontology DOID:4080 tricuspid valve insufficiency A germ cell and embryonal cancer that derives_from trophoblastic tissue. MESH:D014328 NCI:C3422 SNOMEDCT_US_2020_03_01:115234004 UMLS_CUI:C0041182 Trophoblastic neoplasm Trophoblastic tumor disease_ontology DOID:4085 trophoblastic neoplasm DOID:2164 DOID:2165 DOID:46 ICD10CM:K76.9 ICD9CM:573.9 MESH:D008107 NCI:C3196 SNOMEDCT_US_2020_03_01:62857009 UMLS_CUI:C0023895 disorder of liver hepatic disorder disease_ontology DOID:409 liver disease A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss. DOID:4019 GARD:8 ICD10CM:R48.1 MESH:D000377 NCI:C84542 SNOMEDCT_US_2020_03_01:42341009 UMLS_CUI:C0001816 Dyspraxia Dyspraxia syndrome disease_ontology DOID:4090 agnosia MESH:D000377 A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice. MESH:D013984 UMLS_CUI:C0040196 disease_ontology DOID:4109 tick infestation A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host. MESH:D004478 UMLS_CUI:C0013578 ectoparasitism disease_ontology DOID:4110 parasitic ectoparasitic infectious disease An integumentary system disease that is located_in nail. ICD10CM:L60 ICD9CM:703 MESH:D009260 SNOMEDCT_US_2020_03_01:17790008 UMLS_CUI:C0027339 disease_ontology DOID:4123 nail disease MESH:D003137 UMLS_CUI:C0009440 disease_ontology DOID:4137 common bile duct disease MESH:D001649 NCI:C96716 SNOMEDCT_US_2020_03_01:118926004 UMLS_CUI:C0005395 bile duct disorder disorder of bile duct disease_ontology DOID:4138 bile duct disease A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree. DOID:4139 MESH:D001657 SNOMEDCT_US_2020_03_01:43469007 UMLS_CUI:C0005416 sphincter of oddi dysfunction disease_ontology DOID:4140 biliary dyskinesia A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis. DOID:9984 ICD10CM:C69.6 ICD9CM:190.1 MESH:D009918 NCI:C3290 NCI:C3562 SNOMEDCT_US_2020_03_01:127003006 SNOMEDCT_US_2020_03_01:363462005 UMLS_CUI:C0029185 UMLS_CUI:C0153626 malignant neoplasm of orbit neoplasm of orbit proper orbit cancer orbital tumor disease_ontology DOID:4143 orbital cancer GARD:6258 ICD10CM:K00.5 MESH:D003811 NCI:C84667 OMIM:125490 OMIM:125500 ORDO:49042 SNOMEDCT_US_2020_03_01:367461002 UMLS_CUI:C0011436 disease_ontology DOID:4154 OMIM mapping confirmed by DO. [SN]. dentinogenesis imperfecta A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes. ICD9CM:091 SNOMEDCT_US_2020_03_01:186846005 UMLS_CUI:C0153139 Symptomatic early syphilis early symptomatic syphilis early syphilis, symptomatic disease_ontology DOID:4156 primary syphilis An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells. GARD:10421 MESH:D012878 NCI:C2920 SNOMEDCT_US_2020_03_01:94047004 UMLS_CUI:C0007114 CA - skin cancer malignant neoplasm of skin melanoma and Non-melanoma skin cancer disease_ontology cancer of skin DOID:4159 skin cancer NCI:C42048 UMLS_CUI:C1511934 disease_ontology DOID:4160 differentiating neuroblastoma MESH:D018305 NCI:C3790 SNOMEDCT_US_2020_03_01:116381000119105 UMLS_CUI:C0206718 Ganglioneuroblastoma disease_ontology DOID:4163 ganglioneuroblastoma A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. DOID:11095 ICD10CM:A51.0 MESH:D002601 SNOMEDCT_US_2020_03_01:736686006 UMLS_CUI:C0007939 syphilitic chancre disease_ontology DOID:4166 syphilis An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues. autoimmune disease ICD9CM:720 OMIM:109100 UMLS_CUI:C0003089 autoimmune hypersensitivity disease hypersensitivity reaction type II disease disease_ontology DOID:417 Xref MGI. autoimmune disease MESH:D012203 NCI:C113150 SNOMEDCT_US_2020_03_01:199580004 UMLS_CUI:C0035404 Rh incompatibility affecting management of mother disease_ontology DOID:4175 Rh isoimmunization MESH:D001787 UMLS_CUI:C0005806 disease_ontology DOID:4176 blood group incompatibility A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies. EFO:0000717 GARD:9748 ICD10CM:M34.0 ICD9CM:710.1 MESH:D012595 NCI:C72070 OMIM:181750 SNOMEDCT_US_2020_03_01:89155008 UMLS_CUI:C0036421 Scleroderma Scleroderma syndrome progressive systemic sclerosis systemic sclerosis disease_ontology DOID:418 systemic scleroderma GARD:7860 MESH:D011556 NCI:C129722 OMIM:612463 SNOMEDCT_US_2020_03_01:190867002 UMLS_CUI:C0033835 Normocalcemic pseudohypoparathyroidism Pseudopseudohypoparathyroidism disease_ontology DOID:4183 OMIM mapping confirmed by DO. [SN]. pseudopseudohypoparathyroidism GARD:10758 ICD10CM:E20.1 MESH:D011547 NCI:C99027 OMIM:612462 SNOMEDCT_US_2020_03_01:190867002 UMLS_CUI:C0033806 disease_ontology DOID:4184 OMIM mapping confirmed by DO. [SN]. pseudohypoparathyroidism MESH:D011547 A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand. MESH:D001184 SNOMEDCT_US_2020_03_01:8187005 UMLS_CUI:C0003910 Articulation impairment Phonological disorder disease_ontology DOID:4186 articulation disorder A speech disorder that involves a complete inability to speak. MESH:D009155 SNOMEDCT_US_2020_03_01:267771000 UMLS_CUI:C0026884 disease_ontology DOID:4189 mutism A rheumatic disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs. MESH:D012594 NCI:C26746 SNOMEDCT_US_2020_03_01:201440007 UMLS_CUI:C0011644 dermatosclerosis disease_ontology DOID:419 scleroderma DOID:12751 ICD9CM:434.0 MESH:D020767 SNOMEDCT_US_2020_03_01:155401002 UMLS_CUI:C0079102 UMLS_CUI:C0752143 cerebral thrombosis disease_ontology DOID:4193 intracranial thrombosis MESH:D044882 NCI:C53655 SNOMEDCT_US_2020_03_01:126877002 UMLS_CUI:C1257958 disorder of glucose metabolism disease_ontology DOID:4194 glucose metabolism disease ICD10CM:R73.9 MESH:D006943 NCI:C26797 SNOMEDCT_US_2020_03_01:144187006 UMLS_CUI:C0020456 disease_ontology DOID:4195 hyperglycemia A hair disease characterized by hair growth that is abnormal in quantity or location. ICD10CM:L68 MESH:D006983 NCI:C79597 ORDO:79365 SNOMEDCT_US_2020_03_01:201164001 UMLS_CUI:C0020555 disease_ontology DOID:420 hypertrichosis MESH:D020427 NCI:C27596 UMLS_CUI:C0747533 Peroneal Neuropathy disease_ontology DOID:4201 peroneal neuropathy A brain stem cancer that is characterized by mass lesion of the brainstem, associated cranial nerve nuclei and long tracts, has_material_basis_in abnormally proliferating cells, derives_from glial cells. NCI:C8501 SNOMEDCT_US_2020_03_01:444545003 UMLS_CUI:C0677865 Brainstem Neuroglial tumor disease_ontology DOID:4202 brain stem glioma DOID:13974 DOID:4204 DOID:4208 GARD:8244 ICD10CM:C71.7 ICD9CM:191.7 MESH:D020295 NCI:C3570 NCI:C4869 NCI:C4975 NCI:C5967 SNOMEDCT_US_2020_03_01:126961004 SNOMEDCT_US_2020_03_01:93726004 UMLS_CUI:C0153641 UMLS_CUI:C0677866 UMLS_CUI:C0751886 UMLS_CUI:C1332192 malignant neoplasm of brain stem malignant neoplasm of brainstem neoplasm of adult brain stem neoplasm of brain stem primary brain Stem tumor primary brain stem neoplasm disease_ontology DOID:4203 brain stem cancer DOID:12786 ICD10CM:C71.6 ICD9CM:191.6 MESH:D002528 NCI:C2935 NCI:C3569 SNOMEDCT_US_2020_03_01:126960003 SNOMEDCT_US_2020_03_01:449420002 UMLS_CUI:C0007762 UMLS_CUI:C0153640 cerebellar cancer malignant tumor of Cerebellum disease_ontology DOID:4205 cerebellum cancer An integumentary system disease that is located_in hair. MESH:D006201 NCI:C34656 SNOMEDCT_US_2020_03_01:267862002 UMLS_CUI:C0018500 disease_ontology DOID:421 hair disease A malignant ovarian surface epithelial-stromal neoplasm that has_material_basis_in the surface epithelium of the ovary. MESH:D001948 NCI:C4270 SNOMEDCT_US_2020_03_01:42194009 UMLS_CUI:C0334495 disease_ontology DOID:4217 malignant ovarian Brenner tumor MESH:D020914 NCI:C84648 UMLS_CUI:C0752282 disease_ontology DOID:422 congenital structural myopathy A dermatitis that is characterized by a pyogenic infection causing the formation of pus. ICD10CM:L08.0 ICD9CM:686.0 MESH:D011711 SNOMEDCT_US_2020_03_01:267838007 UMLS_CUI:C0034212 disease_ontology DOID:4223 pyoderma An endometrial stromal tumor that has_material_basis in connective tissue. GARD:6339 MESH:D018203 NCI:C8973 SNOMEDCT_US_2020_03_01:70555003 UMLS_CUI:C0206630 ESS Undifferentiated endometrial sarcoma endometrial stromal sarcoma, high grade disease_ontology DOID:4226 endometrial stromal sarcoma A muscular disease in which the muscle fibers do not function resulting in muscular weakness. ICD10CM:G72.9 ICD9CM:359.9 MESH:D009135 NCI:C101216 SNOMEDCT_US_2020_03_01:155094005 UMLS_CUI:C0026848 disease_ontology DOID:423 myopathy NCI:C6511 UMLS_CUI:C1334620 malignant tumor of Smooth Muscle disease_ontology DOID:4230 smooth muscle cancer MESH:D051642 NCI:C35765 SNOMEDCT_US_2020_03_01:154614002 UMLS_CUI:C1509147 disease_ontology DOID:4231 histiocytoma A Ewing sarcoma that is morphologically indistinguishable from skeletal Ewing sarcoma but is located in extraosseous locations. NCI:C27293 ORDO:370334 UMLS_CUI:C1333514 extraosseous Ewing's sarcoma extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumor extraskeletal Ewing sarcom disease_ontology DOID:4232 extraosseous Ewing sarcoma A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated. DOID:4881 MESH:D018227 NCI:C27370 NCI:C3745 SNOMEDCT_US_2020_03_01:12622007 UMLS_CUI:C0206651 UMLS_CUI:C1332198 Clear cell sarcoma Clear cell sarcoma of soft Parts adult soft part clear cell sarcoma malignant melanoma of soft tissues melanoma, malignant, of soft parts disease_ontology malignant melanoma of soft parts DOID:4233 clear cell sarcoma A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy. MESH:D012509 NCI:C27005 SNOMEDCT_US_2020_03_01:9801004 UMLS_CUI:C0205945 disease_ontology DOID:4235 spindle cell sarcoma A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. DOID:1971 DOID:2610 DOID:4234 MESH:D002296 MESH:D018199 MESH:D018200 NCI:C34448 NCI:C3730 NCI:C8975 SNOMEDCT_US_2020_03_01:112684005 SNOMEDCT_US_2020_03_01:63264007 SNOMEDCT_US_2020_03_01:84427001 UMLS_CUI:C0007140 UMLS_CUI:C0206627 UMLS_CUI:C1334603 MMMT Mesodermal mixed tumor malignant mixed Mullerian tumor malignant mixed mesodermal (mullerian) tumor mesodermal mixed tumor mixed Mesodermal (mullerian) tumor mullerian mixed tumor disease_ontology DOID:4236 carcinosarcoma A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults. DOID:5315 DOID:5318 GARD:5654 MESH:D018234 NCI:C3750 NCI:C7943 NCI:C8092 OMIM:606243 ORDO:163699 SNOMEDCT_US_2020_03_01:88195001 UMLS_CUI:C0206657 UMLS_CUI:C0279544 UMLS_CUI:C0279985 Alveolar Soft Part sarcoma disease_ontology DOID:4239 OMIM mapping confirmed by DO. [SN]. alveolar soft part sarcoma A lung disease that is characterized by pulmonary collapse, accompanied by hypoventilation which can affect a lobe, segment, or all of the lung, resulting in a decrease in the ventilation/perfusion ratio. ICD10CM:P28.0 ICD9CM:770.4 SNOMEDCT_US_2020_03_01:42908004 UMLS_CUI:C0270163 primary atelectasis of newborn primary atelectasis, in perinatal period disease_ontology DOID:424 pulmonary immaturity A kidney cancer that is located in the kidney's connective tissue. NCI:C4525 SNOMEDCT_US_2020_03_01:254918001 UMLS_CUI:C0346251 renal sarcoma sarcoma of kidney disease_ontology DOID:4242 kidney sarcoma MESH:D023903 UMLS_CUI:C0948480 disease_ontology DOID:4247 coronary restenosis MESH:D023921 NCI:C80427 SNOMEDCT_US_2020_03_01:233970002 UMLS_CUI:C0242231 Coronary artery stenosis disease_ontology DOID:4248 coronary stenosis A prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain. GARD:7690 ICD10CM:A81.82 ICD9CM:046.71 MESH:D016098 NCI:C84727 OMIM:137440 SNOMEDCT_US_2020_03_01:67155006 UMLS_CUI:C0017495 Gerstmann-Straussler-Scheinker disease PRION DEMENTIA disease_ontology DOID:4249 OMIM mapping confirmed by DO. [SN]. Gerstmann-Straussler-Scheinker syndrome ICD10CM:H11.82 ICD9CM:372.81 SNOMEDCT_US_2020_03_01:408663001 UMLS_CUI:C0878693 disease_ontology DOID:4250 conjunctivochalasis An eye disease affecting the conjunctiva, which is the mucous membrane surrounding the eye and interior of the eyelids. ICD10CM:H11.9 ICD9CM:372.9 MESH:D003229 NCI:C27605 SNOMEDCT_US_2020_03_01:194583004 UMLS_CUI:C0009759 disease_ontology DOID:4251 conjunctival disease A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes. GARD:5774 MESH:D038261 NCI:C84545 OMIM:203450 SNOMEDCT_US_2020_03_01:81854007 UMLS_CUI:C0270726 Alexander's disease disease_ontology DOID:4252 OMIM mapping confirmed by DO. [SN]. Alexander disease MESH:D038261 An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex. GARD:9474 MESH:D008557 NCI:C84887 OMIM:155950 SNOMEDCT_US_2020_03_01:240173003 UMLS_CUI:C0025239 disease_ontology DOID:4253 OMIM mapping confirmed by DO. [SN]. melorheostosis MESH:D008557 A bone remodeling disease that results_in abnormal elevated bone density or mass. ICD10CM:Q78.2 MESH:D010026 NCI:C41236 SNOMEDCT_US_2020_03_01:49347007 UMLS_CUI:C0029464 disease_ontology DOID:4254 osteosclerosis A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has symptom soft-tissue swelling, has symptom bone lesions, and has symptom irritability. GARD:1051 ICD10CM:M89.8 MESH:D006958 NCI:C84645 OMIM:114000 SNOMEDCT_US_2020_03_01:24752008 UMLS_CUI:C0020497 cortical congenital hyperostosis infantile cortical hyperostosis disease_ontology DOID:4257 OMIM mapping confirmed by DO. [SN]. Caffey disease MESH:D020235 SNOMEDCT_US_2020_03_01:30767006 UMLS_CUI:C1510417 disease_ontology DOID:4260 gait apraxia MESH:D020235 A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness. MESH:D000405 SNOMEDCT_US_2020_03_01:53333005 UMLS_CUI:C0001889 Coma vigilans disease_ontology DOID:4267 akinetic mutism MESH:D000405 A microsporidiosis that is a zoonotic infectious disease results_in disseminated fungal infection in dogs, cats, hamsters, guinea pigs, rats, mice and humans, has_material_basis_in Encephalitozoon cuniculi, has_material_basis_in Encephalitozoon intestinalis or has_material_basis_in Encephalitozoon hellem. MESH:D016890 SNOMEDCT_US_2020_03_01:12825006 UMLS_CUI:C0085412 Infection by Encephalitozoon disease_ontology DOID:4270 encephalitozoonosis An opportunistic mycosis that results_in systemic fungal infection in immunocompromised people, has_material_basis_in Microsporidia phylum members. GARD:3655 ICD10CM:B60.8 MESH:D016881 NCI:C84891 SNOMEDCT_US_2020_03_01:61842000 UMLS_CUI:C0085407 Infection by Microspora Infection by Microsporea Infection by Microsporida disease_ontology DOID:4271 microsporidiosis A basal cell carcinoma characterized by elevated, pearl shaped nodules with telengactisae on the surface and periphery. DOID:4296 NCI:C62282 SNOMEDCT_US_2020_03_01:716274007 UMLS_CUI:C1304300 Basal cell carcinoma, nodular Circumscribed solid basal cell carcinoma skin nodulo-ulcerative basal cell carcinoma skin solid (nodular) Basal cell carcinoma disease_ontology DOID:4280 nodular basal cell carcinoma An external ear cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C6081 UMLS_CUI:C1333492 carcinoma of the External ear disease_ontology carcinoma of external ear DOID:4288 external ear carcinoma A congenital heart disease that is characterized by partial or entire anomalous curved venous drainage of the right lung to the inferior vena cava, association with variable right lung and pulmonary artery hypoplasia, dextraposition of the heart and an anomalous systemic blood supply to the ipsilateral lung. ICD10CM:Q26.8 MESH:D012587 NCI:C85056 OMIM:106700 ORDO:185 SNOMEDCT_US_2020_03_01:39905002 UMLS_CUI:C0036400 Halasz syndrome congenital venolobar syndrome hypogenetic lung syndrome mirror-image lung syndrome pulmonary venolobar syndrome total anomalous pulmonary venous return vena cava bronchovascular syndrome disease_ontology DOID:4297 scimitar syndrome A benign giant cell tumor that results_in the presence of multinucleated giant cells. MESH:D018212 NCI:C121932 SNOMEDCT_US_2020_03_01:697970009 UMLS_CUI:C0206638 Giant cell neoplasm of bone Giant cell tumor of bone Giant cell tumour of bone bone giant cell tumour disease_ontology giant cell myeloma osteoclastoma DOID:4305 bone giant cell tumor A peripheral nervous system disease that is characterized by the pinching of a nerve root in the spine and has symptoms of pain, weakness, numbness and tingling. ICD10CM:M54.1 MESH:D011843 SNOMEDCT_US_2020_03_01:394640000 UMLS_CUI:C0700594 pinched nerve disease_ontology DOID:4306 radiculopathy MESH:D009209 UMLS_CUI:C0027073 disease_ontology DOID:431 myofascial pain syndrome MESH:D018235 NCI:C3751 SNOMEDCT_US_2020_03_01:75109009 UMLS_CUI:C0206658 disease_ontology DOID:4310 smooth muscle tumor An acquired epidermolysis bullosa that is characterized by formation of recurrent blisters secondary to minor trauma in the skin and mucosa, and has_material_basis_in the development of autoantibodies to type VII collagen. ICD10CM:L12.3 MESH:D016107 NCI:C84690 SNOMEDCT_US_2020_03_01:2772003 UMLS_CUI:C0079293 acquired epidermolysis bullosa disease_ontology DOID:4313 epidermolysis bullosa acquisita NCI:C27516 SNOMEDCT_US_2020_03_01:733892008 UMLS_CUI:C1333414 disease_ontology DOID:4323 epidermolytic acanthoma A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted by contaminated fomites, or transmitted by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding. GARD:2035 ICD10CM:A98.4 MESH:D019142 NCI:C36171 SNOMEDCT_US_2020_03_01:123323003 UMLS_CUI:C0282687 Ebola virus disease disease_ontology DOID:4325 Ebola hemorrhagic fever A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding. GARD:9444 ICD10CM:A98.3 MESH:D008379 NCI:C84883 SNOMEDCT_US_2020_03_01:123322008 UMLS_CUI:C0024788 Marburg disease Marburg virus disease disease_ontology DOID:4327 Marburg hemorrhagic fever GARD:8231 MESH:D015616 SNOMEDCT_US_2020_03_01:127069007 UMLS_CUI:C0019624 disease_ontology DOID:4330 non-Langerhans-cell histiocytosis A female reproductive system disease that is characterized by epithelium-lined fluid-filled cysts in the adnexa adjacent to the fallopian tube and ovary. ICD10CM:Q50.5 MESH:D010310 SNOMEDCT_US_2020_03_01:204831002 UMLS_CUI:C0030584 Cyst, fimbrial Embryonic fimbrial cyst disease_ontology DOID:4333 parovarian cyst A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring. DOID:0050109 ICD10CM:B35 MESH:D014007 NCI:C35072 SNOMEDCT_US_2020_03_01:85375000 UMLS_CUI:C0040254 favus disease_ontology DOID:4336 tinea favosa A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern. DOID:0050114 DOID:12319 ICD9CM:110.0 NCI:C34536 SNOMEDCT_US_2020_03_01:186985002 UMLS_CUI:C0011640 Scalp ringworm Trichophyton rubrum tinea capitis dermatophytosis of scalp or beard tinea capitis due to Trichophyton rubrum disease_ontology Dermatophytosis of scalp DOID:4337 tinea capitis GARD:7848 MESH:D046350 NCI:C85219 OMIM:176200 SNOMEDCT_US_2020_03_01:58275005 UMLS_CUI:C0162532 Protocoproporphyria Protoporphyrinogen oxidase deficiency Variegate porphyria disease_ontology DOID:4346 variegate porphyria MESH:D008210 NCI:C78442 SNOMEDCT_US_2020_03_01:234109007 UMLS_CUI:C0024248 Lymph cyst disease_ontology DOID:4347 lymphocele A female reproductive organ cancer that is located_in the cervix. DOID:4361 ICD10CM:C53 ICD9CM:180 MESH:D002583 NCI:C2940 NCI:C9311 OMIM:603956 SNOMEDCT_US_2020_03_01:123841004 SNOMEDCT_US_2020_03_01:254885005 UMLS_CUI:C0007847 UMLS_CUI:C0007873 cervical neoplasm cervix cancer cervix uteri cancer neoplasm of uterine cervix tumor of the Cervix Uteri uterine cervical neoplasm disease_ontology DOID:4362 cervical cancer A steroid inherited metabolic disorder characterized by decreased conversion of biologically active cortisol to inactive cortisone resulting in low aldosterone levels, metabolic alkalosis, hypernatremia, hypokalemia and early-onset severe hypertension that has_material_basis_in homozygous or compound heterozygous mutation in the HSD11B2 gene on chromosome 16. DOID:0090121 GARD:433 MESH:D043204 NCI:C123231 OMIM:218030 ORDO:320 SNOMEDCT_US_2020_03_01:237770005 UMLS_CUI:C0342488 11-beta-hydroxysteroid dehydrogenase deficiency type 2 Ulick syndrome cortisol 11-beta-ketoreductase deficiency syndrome of apparent mineralocorticoid excess disease_ontology DOID:4367 apparent mineralocorticoid excess syndrome An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath. DOID:443 DOID:444 GARD:7122 ICD10CM:G70.0 ICD10CM:G70.00 ICD9CM:358.0 ICD9CM:358.00 MESH:D009157 NCI:C60989 OMIM:254200 SNOMEDCT_US_2020_03_01:155092009 UMLS_CUI:C0026896 UMLS_CUI:C1260409 disease_ontology DOID:437 OMIM mapping confirmed by DO. [SN]. myasthenia gravis A hypersensitivity reaction type IV disease that is characterized by chronic urticarial rash and monoclonal IgM gammopathy, has_symptom rash, intermittent fever, arthralgia, and lymphadenopathy. GARD:12390 MESH:D019873 SNOMEDCT_US_2020_03_01:402415001 UMLS_CUI:C0524988 disease_ontology DOID:4371 Schnitzler syndrome DOID:1957 DOID:1958 ICD10CM:I66 ICD9CM:434.1 MESH:D020766 SNOMEDCT_US_2020_03_01:75543006 UMLS_CUI:C0007780 UMLS_CUI:C0752140 Cerebral embolism with cerebral infarction cerebral embolism disease_ontology DOID:4372 intracranial embolism A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms. MESH:D021181 SNOMEDCT_US_2020_03_01:91930004 UMLS_CUI:C0559469 Allergy to eggs disease_ontology DOID:4377 egg allergy A legume allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms. MESH:D021183 SNOMEDCT_US_2020_03_01:91935009 UMLS_CUI:C0559470 allergy to peanuts peanut allergic reaction disease_ontology DOID:4378 peanut allergy An autoimmune disease affecting the nervous system. MESH:D020274 NCI:C99383 UMLS_CUI:C0751871 disease_ontology autoimmune nervous system disorder DOID:438 autoimmune disease of the nervous system MESH:D047708 SNOMEDCT_US_2020_03_01:128917003 UMLS_CUI:C1266121 Lipoleiomyoma Myofibroma disease_ontology DOID:4386 myofibroma A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction. MESH:D020511 SNOMEDCT_US_2020_03_01:128213006 UMLS_CUI:C0751950 disease_ontology DOID:439 neuromuscular junction disease ICD10CM:L40.3 MESH:D011565 NCI:C34888 SNOMEDCT_US_2020_03_01:238610005 UMLS_CUI:C0030246 Acropustulosis Palmoplantar Pustulosis Pustular psoriasis of the palms and/or soles disease_ontology DOID:4398 pustulosis of palm and sole NCI:C35277 UMLS_CUI:C0234894 disease_ontology DOID:4399 acneiform dermatitis A neuropathy that affect the nerves that control the voluntary muscles. ICD10CM:G70.9 ICD9CM:358 MESH:D009468 SNOMEDCT_US_2020_03_01:1664005 UMLS_CUI:C0027868 disease_ontology DOID:440 neuromuscular disease MESH:D005499 NCI:C94408 SNOMEDCT_US_2020_03_01:156411003 UMLS_CUI:C0016436 disease_ontology DOID:4409 folliculitis A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice. DOID:12431 GARD:9541 MESH:D016751 SNOMEDCT_US_2020_03_01:7111000119109 UMLS_CUI:C0085293 disease_ontology DOID:4411 hepatitis E MESH:D018219 NCI:C3739 SNOMEDCT_US_2020_03_01:25889007 UMLS_CUI:C0206644 Fibroxanthoma benign fibrous histiocytoma fibrous Histiocytoma disease_ontology DOID:4415 fibrous histiocytoma DOID:4417 GARD:9807 MESH:D018219 NCI:C6801 NCI:C8402 SNOMEDCT_US_2020_03_01:254749001 SNOMEDCT_US_2020_03_01:403999006 UMLS_CUI:C0002991 UMLS_CUI:C0346049 Dermatofibroma Fibrohistiocytic tumor Pleomorphic fibroma Sclerosing angioma Sclerosing angioma of skin benign Cutaneous fibrous Histiocytoma dermatofibroma fibrohistiocytic tumor fibrous histiocytoma of skin fibrous xanthoma of skin disease_ontology DOID:4418 cutaneous fibrous histiocytoma A sphingolipidosis characterized by dysfunctional metabolism of sphingolipids. MESH:D012618 NCI:C85062 OMIM:269600 SNOMEDCT_US_2020_03_01:37821003 UMLS_CUI:C0036489 Sea-blue histiocyte syndrome disease_ontology DOID:4423 OMIM mapping confirmed by DO. [SN]. sea-blue histiocytosis MESH:D014972 NCI:C3451 SNOMEDCT_US_2020_03_01:71709009 UMLS_CUI:C0043324 Multiple eruptive juvenile xanthogranuloma Naevoxanthoendothelioma Xanthoma neviforme disease_ontology DOID:4424 juvenile xanthogranuloma A reading disorder resulting from a developmental reading disability involving the inability to process graphic symbols resulting in impairment of reading ability. ICD10CM:F81.0 MESH:D004410 NCI:C96410 OMIM:300509 OMIM:600202 OMIM:604254 OMIM:606616 OMIM:606896 OMIM:608995 SNOMEDCT_US_2020_03_01:154954003 UMLS_CUI:C0476254 disease_ontology DOID:4428 Xref MGI. dyslexia GARD:4900 MESH:D013005 NCI:C3379 SNOMEDCT_US_2020_03_01:128642005 UMLS_CUI:C0037661 Somatostatin cell neoplasm Somatostatin cell tumour disease_ontology DOID:4430 somatostatinoma NCI:C5272 UMLS_CUI:C1335976 meningioma of the Skull Base disease_ontology DOID:4437 skull base meningioma A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has_material_basis_in abnormally proliferating cells derives_from germ cells. NCI:C5461 UMLS_CUI:C1332880 central nervous system germ cell tumour germ cell tumor of the CNS germ cell tumour of the CNS disease_ontology DOID:4439 central nervous system germ cell tumor A germinoma that has_material_basis_in cells that make sperm and eggs. MESH:D018239 NCI:C9309 SNOMEDCT_US_2020_03_01:443675005 UMLS_CUI:C0036631 Seminoma, Pure disease_ontology DOID:4440 OMIM mapping confirmed by DO. [LS]. seminoma A germ cell cancer that derives_from cells that give rise to egg cells. MESH:D004407 NCI:C2996 SNOMEDCT_US_2020_03_01:60718004 UMLS_CUI:C0013377 disease_ontology DOID:4441 dysgerminoma MESH:D008269 NCI:C34794 OMIM:153880 SNOMEDCT_US_2020_03_01:193387007 UMLS_CUI:C0024440 disease_ontology DOID:4447 OMIM mapping confirmed by DO. [SN]. cystoid macular edema A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss. MESH:D008268 NCI:C123330 ORDO:279 SNOMEDCT_US_2020_03_01:302891003 UMLS_CUI:C0024437 Macular degeneration of retina disease_ontology DOID:4448 Xref MGI. macular degeneration MESH:D008269 NCI:C35468 SNOMEDCT_US_2020_03_01:37231002 UMLS_CUI:C0271051 macular edema macular oedema macular retinal oedema disease_ontology DOID:4449 macular retinal edema GARD:5893 ICD10CM:E26.81 ICD9CM:255.13 MESH:D001477 NCI:C34412 OMIM:PS601678 SNOMEDCT_US_2020_03_01:707742001 UMLS_CUI:C0004775 Aldosteronism with hyperplasia of the adrenal cortex Bartter's syndrome disease_ontology DOID:445 Bartter disease A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney. EFO:0000681 GARD:13215 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 SNOMEDCT_US_2020_03_01:254915003 UMLS_CUI:C0007134 RCC adenocarcinoma of kidney hypernephroma disease_ontology DOID:4450 Xref MGI. renal cell carcinoma A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products). NCI:C9384 SNOMEDCT_US_2020_03_01:254915003 UMLS_CUI:C1378703 carcinoma of kidney kidney carcinoma disease_ontology DOID:4451 renal carcinoma GARD:9571 disease_ontology DOID:4455 hereditary renal cell carcinoma An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands. DOID:12252 ICD10CM:E24 ICD10CM:E26 ICD9CM:255.0 ICD9CM:255.1 MESH:D003480 MESH:D006929 NCI:C113213 NCI:C2969 OMIM:605635 OMIM:613677 ORDO:235936 SNOMEDCT_US_2020_03_01:154705004 SNOMEDCT_US_2020_03_01:88213004 UMLS_CUI:C0010481 UMLS_CUI:C0020428 Cushing syndrome Cushing's syndrome hyperaldosteronism disease_ontology DOID:446 Xref MGI. primary hyperaldosteronism NCI:C4524 SNOMEDCT_US_2020_03_01:254916002 UMLS_CUI:C0346249 cystadenocarcinoma of kidney renal cystadenocarcinoma disease_ontology DOID:4463 multilocular clear cell renal cell carcinoma A renal cell carcinoma that begins in distal collecting ducts of the kidney with a tubulopapillary morphology and intracytoplasmic mucicarminophilic material. GARD:9573 MESH:D002292 NCI:C6194 SNOMEDCT_US_2020_03_01:733470002 UMLS_CUI:C1266044 carcinoma of renal Collecting duct renal Medullary carcinoma renal carcinoma, collecting duct type disease_ontology DOID:4464 collecting duct carcinoma A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors. DOID:8063 GARD:9572 MESH:C538614 MESH:D002292 NCI:C27890 NCI:C6975 OMIM:605074 SNOMEDCT_US_2020_03_01:4797003 UMLS_CUI:C1306837 UMLS_CUI:C1336078 Chromophil carcinoma of kidney Papillary renal cell carcinoma papillary kidney carcinoma sporadic papillary renal cell carcinoma disease_ontology DOID:4465 OMIM mapping confirmed by DO. [SN]. papillary renal cell carcinoma A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope. GARD:9574 MESH:D002292 NCI:C4033 SNOMEDCT_US_2020_03_01:254915003 UMLS_CUI:C0279702 Clear cell carcinoma of kidney clear cell kidney carcinoma conventional (Clear cell) renal cell carcinoma conventional renal cell carcinoma renal clear cell carcinoma disease_ontology Clear-cell metastatic renal cell carcinoma Clear-cell metastatic renal cell carcinoma DOID:4467 MESH:C538445 added from NeuroDevNet [WAK]. clear cell renal cell carcinoma An adenocarcinoma that derives_from epithelial cells which have clear cytoplasm. DOID:2617 DOID:4940 MESH:D008649 MESH:D018262 NCI:C36815 NCI:C4072 NCI:C4156 SNOMEDCT_US_2020_03_01:2221008 SNOMEDCT_US_2020_03_01:30546008 SNOMEDCT_US_2020_03_01:80727009 UMLS_CUI:C0025490 UMLS_CUI:C0206681 UMLS_CUI:C0334322 Clear cell adenocarcinoma Mesonephroid Clear cell carcinoma Mesonephroma Mesonephroma, malignant Water-Clear cell adenocarcinoma Water-clear cell adenocarcinoma Water-clear cell carcinoma Wolffian duct neoplasm malignant Mesonephroma mesonephroma disease_ontology DOID:4468 clear cell adenocarcinoma MESH:D015499 UMLS_CUI:C0035091 inborn renal tubular transport disorder disease_ontology DOID:447 renal tubular transport disease A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells. GARD:6064 MESH:D002292 NCI:C4146 SNOMEDCT_US_2020_03_01:128667008 UMLS_CUI:C1266042 Chromophobe carcinoma of kidney chromophobe adenocarcinoma kidney chromophobe renal cell carcinoma, chromophobe cell disease_ontology DOID:4471 chromophobe renal cell carcinoma MESH:D011546 NCI:C85034 SNOMEDCT_US_2020_03_01:77098009 UMLS_CUI:C0033805 disease_ontology DOID:4479 pseudohypoaldosteronism An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone. GARD:8173 ICD10CM:Q77.4 MESH:D000130 NCI:C34345 OMIM:100800 SNOMEDCT_US_2020_03_01:268273004 UMLS_CUI:C0001080 Achondroplastic physique Chondrodystrophia osteosclerosis congenita disease_ontology DOID:4480 OMIM mapping confirmed by DO. [SN]. achondroplasia MESH:D000130 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites. DOID:12089 DOID:14030 DOID:8241 DOID:8242 EFO:0003956 NCI:C34987 OMIM:607154 SNOMEDCT_US_2020_03_01:38103000 UMLS_CUI:C0002103 Non-seasonal allergic rhinitis Perenial allergic rhinitis atopic rhinitis hay fever pollenosis seasonal allergic rhinitis disease_ontology DOID:4481 allergic rhinitis MESH:D065631 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip. MESH:D012220 NCI:C34986 SNOMEDCT_US_2020_03_01:70076002 UMLS_CUI:C0035455 disease_ontology runny nose DOID:4483 rhinitis An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress. ICD10CM:J09.X MESH:D005585 SNOMEDCT_US_2020_03_01:55604004 UMLS_CUI:C0016627 avian flu bird flu disease_ontology DOID:4492 avian influenza A muscular dystrophy that is characterized by progressive muscle wasting and weakness. ICD10CM:G71.1 ICD9CM:359.2 MESH:D020967 NCI:C84913 SNOMEDCT_US_2020_03_01:155096007 UMLS_CUI:C0553604 disease_ontology DOID:450 myotonic disease MESH:D009223 MESH:D020967 NCI:C34939 UMLS_CUI:C1514284 hypopotassemia potassium deficiency disorder disease_ontology DOID:4500 hypokalemia A syndrome that is characterized by malformations of the face, oral cavity, and digits. ICD10CM:Q87.0 MESH:D009958 SNOMEDCT_US_2020_03_01:52868006 UMLS_CUI:C0029294 oral-facial-digital syndrome disease_ontology DOID:4501 Xref MGI. OMIM mapping confirmed by DO. [SN]. orofaciodigital syndrome A gastrointestinal system benign neoplasm that is a located_in the salivary glands. MESH:D008949 NCI:C35691 OMIM:181030 SNOMEDCT_US_2020_03_01:8360001 UMLS_CUI:C0026277 Pleomorphic adenoma mixed tumor of the Salivary gland disease_ontology DOID:452 pleomorphic adenoma A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells. GARD:10671 MESH:D018277 NCI:C3772 SNOMEDCT_US_2020_03_01:4079000 UMLS_CUI:C0206694 MEC Mucoepidermoid carcinoma disease_ontology DOID:4531 mucoepidermoid carcinoma A syndrome that affects growth, cranial development, hair growth and dental development. GARD:288 MESH:D006210 NCI:C84746 OMIM:234100 ORDO:2108 SNOMEDCT_US_2020_03_01:7903009 UMLS_CUI:C0018522 Francois dyscephalic syndrome Hallerman - Streiff syndrome Hallermann's syndrome disease_ontology DOID:4534 OMIM mapping confirmed by DO. [SN]. Hallermann-Streiff syndrome A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles. MESH:D007039 OMIM:PS605389 ORDO:55654 SNOMEDCT_US_2020_03_01:53602002 UMLS_CUI:C0020678 disease_ontology DOID:4535 Xref MGI. hypotrichosis A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper. ICD10CM:R48.8 MESH:D000381 SNOMEDCT_US_2020_03_01:27206009 UMLS_CUI:C0001825 disease_ontology DOID:4540 dysgraphia An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection. ICD10CM:R41.2 MESH:D000648 NCI:C34372 SNOMEDCT_US_2020_03_01:51921000 UMLS_CUI:C0002624 disease_ontology DOID:4543 retrograde amnesia MESH:D018211 NCI:C3737 SNOMEDCT_US_2020_03_01:56565002 UMLS_CUI:C0206637 disease_ontology DOID:4545 mesenchymal chondrosarcoma NCI:C27481 SNOMEDCT_US_2020_03_01:404080006 UMLS_CUI:C1275279 mesenchymal extraosseous chondrosarcoma disease_ontology DOID:4548 extraskeletal mesenchymal chondrosarcoma A chondrosarcoma that is located_in exclusively soft tissue. disease_ontology DOID:4549 extraosseous chondrosarcoma MESH:D001005 NCI:C2877 SNOMEDCT_US_2020_03_01:126849006 UMLS_CUI:C0003463 anal neoplasm anal tumors neoplasm of anus disease_ontology DOID:4551 anus benign neoplasm NCI:C4450 SNOMEDCT_US_2020_03_01:254629004 UMLS_CUI:C0345958 large cell carcinoma of lung large cell lung carcinoma disease_ontology DOID:4556 lung large cell carcinoma A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation. ICD10CM:B77 ICD9CM:127.0 MESH:D001196 NCI:C128392 SNOMEDCT_US_2020_03_01:2435008 UMLS_CUI:C0003950 Ascariasis - roundworm disease_ontology Ascaris lumbricoides infection DOID:456 ascariasis MESH:D008579 NCI:C4055 SNOMEDCT_US_2020_03_01:724171006 UMLS_CUI:C0281784 meningioma, benign disease_ontology DOID:4587 benign meningioma NCI:C4720 SNOMEDCT_US_2020_03_01:19453003 UMLS_CUI:C0431119 Lymphoplasmacyte-Rich meningioma Lymphoplasmocyte-rich meningioma disease_ontology DOID:4591 lymphoplasmacyte-rich meningioma GARD:1039 ICD10CM:Q80.3 MESH:D017488 NCI:C62569 OMIM:113800 SNOMEDCT_US_2020_03_01:20512000 UMLS_CUI:C0079153 Bullous ichthyosiform erythroderma Epidermolytic palmoplantar hyperkeratosis bullous congenital ichthyosiform erythroderma disease_ontology DOID:4603 OMIM mapping confirmed by DO. [SN]. epidermolytic hyperkeratosis A biliary tract cancer that is located_in the bile duct. DOID:10019 ICD10CM:C24.0 ICD9CM:156.1 MESH:D001650 NCI:C2898 NCI:C7483 SNOMEDCT_US_2020_03_01:93790004 UMLS_CUI:C0005396 UMLS_CUI:C0153453 Ca extrahepatic bile ducts bile duct tumor malignant neoplasm of the extrahepatic bile duct disease_ontology DOID:4606 bile duct cancer A hepatobiliary system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct. DOID:8092 GARD:5924 GARD:9304 ICD10CM:C24.9 ICD9CM:156.9 MESH:D001661 SNOMEDCT_US_2020_03_01:126853008 SNOMEDCT_US_2020_03_01:93688006 UMLS_CUI:C0005426 UMLS_CUI:C0750952 malignant tumour of biliary tract disease_ontology DOID:4607 biliary tract cancer DOID:2692 MESH:D009379 MESH:D019042 NCI:C4063 SNOMEDCT_US_2020_03_01:115228006 UMLS_CUI:C0027664 UMLS_CUI:C0282606 Myomatous neoplasm Myomatous tumor muscle neoplasm muscle tissue neoplasm neoplasm of muscle disease_ontology DOID:461 muscle benign neoplasm A gastrointestinal system benign neoplasm that is located_in the intestine. MESH:D007414 NCI:C3141 SNOMEDCT_US_2020_03_01:126769007 UMLS_CUI:C0021841 intestinal tumors intestine growth neoplasm of intestinal tract disease_ontology DOID:4610 intestinal benign neoplasm MESH:D020424 SNOMEDCT_US_2020_03_01:55802003 UMLS_CUI:C0154743 Ulnar neuropathy disease_ontology DOID:4613 ulnar neuropathy A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies. GARD:6665 ICD10CM:Q04.2 MESH:D016142 NCI:C74988 OMIM:PS236100 ORDO:2162 SNOMEDCT_US_2020_03_01:30915001 UMLS_CUI:C0079541 Holoprosencephaly sequence disease_ontology DOID:4621 Xref MGI. OMIM mapping confirmed by DO. [SN]. holoprosencephaly A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet. GARD:7251 ICD10CM:Q78.4 MESH:D004687 NCI:C3213 OMIM:166000 ORDO:296 SNOMEDCT_US_2020_03_01:46041001 UMLS_CUI:C0024454 DYSCHONDROPLASIA ENCHONDROMATOSIS, MULTIPLE Enchondromatosis with haemangiomata Kast's syndrome OSTEOCHONDROMATOSIS disease_ontology DOID:4624 OMIM mapping confirmed by DO. [SN]. Ollier disease GARD:6681 ICD10CM:Q04.3 MESH:D006832 NCI:C98949 SNOMEDCT_US_2020_03_01:30023002 UMLS_CUI:C0020225 disease_ontology DOID:4626 hydranencephaly MESH:D020240 SNOMEDCT_US_2020_03_01:39746003 UMLS_CUI:C0234523 Classic apraxia Ideomotor dyspraxia Limb-kinetic apraxia Transcortical apraxia disease_ontology DOID:4627 ideomotor apraxia NCI:C26937 SNOMEDCT_US_2020_03_01:3502005 UMLS_CUI:C0149642 cervical Lymphadenitis cervical lymphadenitis disease_ontology DOID:4637 cervical adenitis NCI:C27135 SNOMEDCT_US_2020_03_01:48573006 UMLS_CUI:C0392051 Suppurative lymphadenopathy disease_ontology DOID:4639 suppurative lymphadenitis An epidermolysis bullosa that is characterized by recurrent blistering at the level of the epidermis secondary to minor trauma, which can cause limited wounds, dehydration, electrolyte abnormalities, severe infection, among other issues, and has_material_basis_in mutation in the KRT5, KRT14, or PLEC genes, which encode keratin and plectin proteins that provide resilience in skin. GARD:10752 ICD10CM:Q81.0 MESH:D016110 NCI:C84692 OMIM:601001 OMIM:615425 ORDO:304 SNOMEDCT_US_2020_03_01:205585003 UMLS_CUI:C0079298 Epidermolysis bullosa simplex disease_ontology DOID:4644 epidermolysis bullosa simplex DOID:770 ICD10CM:C69.2 ICD9CM:190.5 MESH:D019572 NCI:C3216 NCI:C4800 SNOMEDCT_US_2020_03_01:127002001 SNOMEDCT_US_2020_03_01:93987004 UMLS_CUI:C0024622 UMLS_CUI:C0524801 Retinal tumor malignant Retinal neoplasm malignant neoplasm of retina malignant tumor of retina neoplasm of retina disease_ontology DOID:4645 retinal cancer MESH:D012175 NCI:C8495 UMLS_CUI:C0751483 Hereditary Retinoblastoma disease_ontology DOID:4648 familial retinoblastoma A retinoblastoma that develops in both eyes. NCI:C8713 UMLS_CUI:C0854914 disease_ontology DOID:4650 bilateral retinoblastoma ICD10CM:D47.02 MESH:D034721 NCI:C9286 SNOMEDCT_US_2020_03_01:70910003 UMLS_CUI:C0272203 ISM Indolent systemic mastocytosis disease_ontology DOID:4660 indolent systemic mastocytosis A syndrome that is an adverse physical reaction to low levels of many common chemicals. MESH:D018777 SNOMEDCT_US_2020_03_01:702772003 UMLS_CUI:C0242992 20th century disease chemical AIDS environmental illness idiopathic environmental illness total allergy syndrome disease_ontology DOID:4661 multiple chemical sensitivity A disorder of sexual developement that is characterized by the inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup. DOID:4672 GARD:5803 ICD10CM:E34.5 ICD9CM:259.51 NCI:C27226 OMIM:300068 ORDO:754 SNOMEDCT_US_2020_03_01:12313004 UMLS_CUI:C0039585 Androgen resistance syndrome Androgen-Insensitivity Syndrome Feminisation - testicular Goldberg - Maxwell syndrome Goldberg-Maxwell syndrome testicular Feminization syndrome testicular feminization disease_ontology DOID:4674 OMIM mapping confirmed by DO. [SN]. androgen insensitivity syndrome MESH:D013734 A corneal disease that is characterized by inflammation of the cornea. ICD10CM:H16 ICD9CM:370 MESH:D007634 NCI:C26805 SNOMEDCT_US_2020_03_01:193757003 UMLS_CUI:C0022568 disease_ontology DOID:4677 keratitis MESH:D006391 NCI:C3699 SNOMEDCT_US_2020_03_01:54249004 UMLS_CUI:C0205789 Intramuscular Angioma Intramuscular hemangioma disease_ontology DOID:468 intramuscular hemangioma A breast carcinoma that represents a mixed group of malignant neoplasms characterized by the histologic presence of two or more cellular types. GARD:10804 NCI:C5164 SNOMEDCT_US_2020_03_01:763479005 UMLS_CUI:C1334708 Metaplastic carcinoma of the breast disease_ontology metaplastic carcinoma of breast DOID:4680 breast metaplastic carcinoma NCI:C3860 SNOMEDCT_US_2020_03_01:372101000 UMLS_CUI:C0238019 carcinoma of extrahepatic bile duct extrahepatic bile duct cancer disease_ontology DOID:4682 extrahepatic bile duct carcinoma NCI:C4472 SNOMEDCT_US_2020_03_01:254713002 UMLS_CUI:C0346019 Mucoepidermoid carcinoma of skin Mucoepidermoid skin carcinoma disease_ontology DOID:4683 cutaneous mucoepidermoid carcinoma A globe disease that is characterized by inflammation of the inside of the eye. MESH:D009877 NCI:C34586 SNOMEDCT_US_2020_03_01:1847009 UMLS_CUI:C0014236 disease_ontology DOID:4692 endophthalmitis DOID:8371 GARD:12698 MESH:D018317 NCI:C4973 NCI:C6912 SNOMEDCT_US_2020_03_01:128795001 UMLS_CUI:C0751691 UMLS_CUI:C1370657 soft tissue Perineurioma disease_ontology DOID:4697 perineurioma ICD10CM:N42.9 ICD9CM:602.9 MESH:D011469 NCI:C26865 SNOMEDCT_US_2020_03_01:30281009 UMLS_CUI:C0033575 disease_ontology DOID:47 prostate disease MESH:D049328 NCI:C3945 SNOMEDCT_US_2020_03_01:40467008 UMLS_CUI:C0265985 Mongolian Macula disease_ontology DOID:4702 mongolian spot A brain cancer that is located_in the infratentorial region. DOID:4789 ICD10CM:C71.7 MESH:D015192 NCI:C3139 NCI:C4966 UMLS_CUI:C0021432 UMLS_CUI:C0751593 brain neoplasm, Infratentorial malignant Infratentorial tumors disease_ontology DOID:4706 infratentorial cancer NCI:C5280 UMLS_CUI:C1333630 meningioma of the Foramen Magnum disease_ontology DOID:4708 foramen magnum meningioma NCI:C4905 SNOMEDCT_US_2020_03_01:254773009 UMLS_CUI:C0687140 Angioma of the skin Angiomatous naevus of skin disease_ontology DOID:471 skin hemangioma A brain disease that is characterized by low pressure inside the skull, and thus in the brain tissue and cerebrospinal fluid; may occur as a result of an occult or iatrogenically caused leak of CSF into another body cavity; may result in the downward displacement of the cerebellar tonsils through the foramen magnum or Chiari malformation; has_symptom orthostatic headache; other symptoms are related to compression of cranial nerves due to brain sagging. MESH:D019585 SNOMEDCT_US_2020_03_01:433691000124104 UMLS_CUI:C0524812 disease_ontology DOID:4723 intracranial hypotension A brain disease that is characterized by excess accumulation of fluid in the intracellular and/or extracellular spaces of the brain, has_symptom nausea, has_symptom vomiting, has_symptom blurred vision, has_symptom seizure, has_symptom coma. MESH:D001929 SNOMEDCT_US_2020_03_01:85974009 UMLS_CUI:C1527311 intracranial swelling wet brain disease_ontology DOID:4724 brain edema A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. DOID:10133 DOID:144 ICD10CM:F45 ICD10CM:F45.0 ICD9CM:300.8 ICD9CM:300.81 MESH:D013001 NCI:C34956 SNOMEDCT_US_2020_03_01:192430009 SNOMEDCT_US_2020_03_01:60368009 UMLS_CUI:C0037650 UMLS_CUI:C0520482 physiological malfunction arising from mental factor psychophysiologic disorder psychosomatic disorder disease_ontology DOID:4737 somatoform disorder MESH:D006391 NCI:C4298 SNOMEDCT_US_2020_03_01:253054009 UMLS_CUI:C0205788 Angiolymphoid hyperplasia with eosinophilia epithelioid haemangioma epithelioid hemangioma disease_ontology DOID:474 histiocytoid hemangioma A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium. ICD10CM:O43.21 MESH:D010921 NCI:C26856 SNOMEDCT_US_2020_03_01:70129008 UMLS_CUI:C0032044 disease_ontology DOID:4744 placenta accreta ICD10CM:G23.2 MESH:D020955 NCI:C125695 OMIM:271930 OMIM:500003 OMIM:609161 SNOMEDCT_US_2020_03_01:29618004 UMLS_CUI:C0270733 disease_ontology DOID:4751 OMIM mapping confirmed by DO. [LS]. striatonigral degeneration DOID:11510 GARD:7079 MESH:D012791 MESH:D019578 NCI:C84909 SNOMEDCT_US_2020_03_01:16576004 SNOMEDCT_US_2020_03_01:230297002 UMLS_CUI:C0037019 UMLS_CUI:C0393571 Multiple system atrophy Shy-Drager syndrome disease_ontology DOID:4752 OMIM mapping confirmed by DO. [LS]. multiple system atrophy A lung cancer that has_material_basis_in tissues of the lung and has_material_basis_in pleural tissues. It is most commonly effects children. MESH:D018202 NCI:C3732 SNOMEDCT_US_2020_03_01:189815007 UMLS_CUI:C0206629 Blastoma of lung disease_ontology DOID:4765 pulmonary blastoma A pulmonary blastoma that derives_from the lung or pleural cavity. GARD:8757 MESH:C537516 NCI:C5669 OMIM:601200 SNOMEDCT_US_2020_03_01:707670009 UMLS_CUI:C1266144 Pleuropulmonary blastoma disease_ontology DOID:4769 OMIM mapping confirmed by DO. [SN]. pleuropulmonary blastoma A kidney cancer that is characterized by the presence of fibroblastic cells. DOID:4772 GARD:1493 MESH:D018201 NCI:C6569 UMLS_CUI:C1332965 disease_ontology DOID:4773 congenital mesoblastic nephroma NCI:C35799 UMLS_CUI:C0859036 disease_ontology DOID:4781 diffuse glomerulonephritis NCI:C5817 UMLS_CUI:C1334246 intracranial PNET disease_ontology DOID:4788 intracranial primitive neuroectodermal tumor DOID:665 MESH:D000794 NCI:C2874 NCI:C4488 SNOMEDCT_US_2020_03_01:254788004 SNOMEDCT_US_2020_03_01:26810009 UMLS_CUI:C0002985 UMLS_CUI:C0346075 Angiokeratoma Angiokeratoma of skin Cutaneous Angiokeratoma skin angiokeratoma disease_ontology DOID:479 angiokeratoma MESH:D018242 NCI:C4327 SNOMEDCT_US_2020_03_01:715903004 UMLS_CUI:C0334596 Diktyoma, malignant Medulloepithelioma Medulloepithelioma, central nervous system disease_ontology DOID:4790 medulloepithelioma GARD:7366 NCI:C6968 SNOMEDCT_US_2020_03_01:699318007 UMLS_CUI:C1336538 Supratentorial PNET disease_ontology DOID:4791 supratentorial primitive neuroectodermal tumor MESH:D018242 NCI:C4915 SNOMEDCT_US_2020_03_01:253070006 UMLS_CUI:C0700367 disease_ontology DOID:4794 ependymoblastoma MESH:D018489 SNOMEDCT_US_2020_03_01:21162009 UMLS_CUI:C0242700 disease_ontology DOID:4796 space motion sickness NCI:C9284 SNOMEDCT_US_2020_03_01:397357000 UMLS_CUI:C1301365 systemic mastocytosis with associated clonal haematological non-mast cell lineage disease systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease disease_ontology DOID:4797 SM-AHNMD A reproductive system disease that affects male reproductive organs. ICD10CM:N50.9 ICD9CM:608.9 MESH:D005832 SNOMEDCT_US_2020_03_01:64557000 UMLS_CUI:C0017412 disease_ontology DOID:48 male reproductive system disease A brain disease that is characterized by a clinical syndrome of either hyperkinetic movement or hyperkinetic movement unrelated to weakness or spasticity. MESH:D009069 NCI:C116757 SNOMEDCT_US_2020_03_01:60342002 UMLS_CUI:C0026650 disease_ontology DOID:480 movement disease A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma. GARD:5622 MESH:D019294 NCI:C84628 OMIM:213700 SNOMEDCT_US_2020_03_01:63246000 UMLS_CUI:C0238052 Cholestanol storage disease disease_ontology DOID:4810 OMIM mapping confirmed by DO. [SN]. cerebrotendinous xanthomatosis An autonomic nervous system benign neoplasm that is characterized by the presence of mature ganglion cells and a mature Schwannian stroma and arises from the sympathetic trunk in the mediastinum. MESH:D005729 NCI:C3049 NCI:C42065 SNOMEDCT_US_2020_03_01:189929007 UMLS_CUI:C0017075 UMLS_CUI:C1513025 disease_ontology DOID:4817 ganglioneuroma ICD10CM:D18.0 MESH:D006392 NCI:C3086 SNOMEDCT_US_2020_03_01:67668002 UMLS_CUI:C0018920 Cavernoma Cavernous haemangioma Cavernous hemangioma disease_ontology DOID:483 cavernous hemangioma A squamous cell carcinoma that contains squamous cells and gland-like cells. MESH:D018196 NCI:C3727 SNOMEDCT_US_2020_03_01:403902008 UMLS_CUI:C0206623 Adenosquamous carcinoma Adenosquamous cell carcinoma mixed adenocarcinoma and squamous carcinoma disease_ontology DOID:4830 adenosquamous carcinoma A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones. GARD:6542 MESH:D010015 SNOMEDCT_US_2020_03_01:240161003 UMLS_CUI:C0029436 Disappearing bone disease Gorham disease essential osteolysis massive osteolysis phantom bone disease disease_ontology Gorham-Stout Syndrome DOID:4837 Gorham's disease A carcinoma that derives_from myoepithelial cells. GARD:10558 NCI:C7596 SNOMEDCT_US_2020_03_01:24292006 UMLS_CUI:C0334699 disease_ontology DOID:4838 myoepithelial carcinoma MESH:D020141 SNOMEDCT_US_2020_03_01:21112004 UMLS_CUI:C0600502 disease_ontology DOID:484 vascular hemostatic disease ICD10CM:C44 NCI:C8409 SNOMEDCT_US_2020_03_01:188083002 UMLS_CUI:C1382026 malignant Sebaceous tumor malignant neoplasm of sebaceous gland disease_ontology DOID:4840 sebaceous carcinoma MESH:D018315 NCI:C3795 SNOMEDCT_US_2020_03_01:4553004 UMLS_CUI:C0206725 Subependymal astrocytoma WHO grade I Ependymal tumor mixed subependymoma-ependymoma disease_ontology DOID:4843 subependymal glioma MESH:D004806 NCI:C3017 SNOMEDCT_US_2020_03_01:443643007 UMLS_CUI:C0014474 WHO grade II Ependymal tumor epithelial ependymoma disease_ontology DOID:4844 benign ependymoma NCI:C40315 SNOMEDCT_US_2020_03_01:388600004 UMLS_CUI:C1519086 disease_ontology DOID:4845 pilomyxoid astrocytoma NCI:C9475 UMLS_CUI:C0740480 astrocytoma of Cerebellum disease_ontology DOID:4848 cerebellar astrocytoma A pediatric low-grade glioma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain. GARD:9808 MESH:D001254 NCI:C4047 SNOMEDCT_US_2020_03_01:67859002 UMLS_CUI:C0334583 Piloid astrocytoma grade I Astrocytic tumor disease_ontology DOID:4851 pilocytic astrocytoma A salivary gland carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes. MESH:D003528 NCI:C2970 SNOMEDCT_US_2020_03_01:11671000 UMLS_CUI:C0010606 Cylindroma adenoid cystic cancer adenoid cystic carcinoma disease_ontology DOID:4866 salivary gland adenoid cystic carcinoma ICD9CM:335 MESH:D016472 SNOMEDCT_US_2020_03_01:267693003 UMLS_CUI:C0154681 disease_ontology DOID:4873 anterior horn cell disease A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue. ICD10CM:A93.2 MESH:D003121 SNOMEDCT_US_2020_03_01:186607005 UMLS_CUI:C0009400 Tick fever, American mountain disease_ontology DOID:4885 Colorado tick fever An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough. DOID:4888 ICD10CM:A18.2 MESH:D014388 MESH:D018601 NCI:C26896 SNOMEDCT_US_2020_03_01:10893003 UMLS_CUI:C0041316 UMLS_CUI:C0242830 Lymph Node Tuberculosis Tuberculous adenitis Tuberculous lymphadenopathy king's evil scrofula disease_ontology DOID:4889 lymph node tuberculosis A bile duct carcinoma that derives_from epithelial cells of glandular origin. NCI:C27813 SNOMEDCT_US_2020_03_01:70179006 UMLS_CUI:C1370800 disease_ontology DOID:4896 bile duct adenocarcinoma A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. MESH:D001650 NCI:C27814 SNOMEDCT_US_2020_03_01:70179006 UMLS_CUI:C0740277 disease_ontology DOID:4897 bile duct carcinoma pulmonary hemangioma disease_ontology DOID:490 hemangioma of lung An appendix cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C9330 SNOMEDCT_US_2020_03_01:269541000 UMLS_CUI:C0728951 Ca appendix carcinoma of appendix disease_ontology DOID:4902 appendix carcinoma A pancreas cancer that derives_from epithelial cells located_in the pancreas. EFO:0002618 MESH:C562463 NCI:C3850 OMIM:260350 SNOMEDCT_US_2020_03_01:154475002 UMLS_CUI:C0235974 Exocrine pancreas carcinoma carcinoma of pancreas disease_ontology Pancreatic carcinoma, familial Pancreatic carcinoma, familial exocrine cancer DOID:4905 OMIM mapping confirmed by DO. [SN]. pancreatic carcinoma A small intestine carcinoma that derives_from epithelial cells of glandular origin. GARD:13090 NCI:C7888 SNOMEDCT_US_2020_03_01:424440001 UMLS_CUI:C0278803 small intestinal adenocarcinoma disease_ontology adenocarcinoma of small Intestine DOID:4906 small intestine adenocarcinoma A small intestine cancer that develops from epithelial cells and is located_in the small intestine. NCI:C7724 UMLS_CUI:C0238196 small intestinal carcinoma disease_ontology cancer of the small bowel small bowel cancer DOID:4907 small intestine carcinoma A anus cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the anus. MESH:D001005 NCI:C9291 SNOMEDCT_US_2020_03_01:187762000 UMLS_CUI:C0279637 Ca anus carcinoma of anus disease_ontology DOID:4908 anal carcinoma MESH:D010911 NCI:C4536 SNOMEDCT_US_2020_03_01:128665000 UMLS_CUI:C0346300 carcinoma of the Pituitary gland disease_ontology DOID:4916 pituitary carcinoma DOID:12343 ICD10CM:C65 ICD9CM:189.1 NCI:C6142 NCI:C7525 SNOMEDCT_US_2020_03_01:363457009 UMLS_CUI:C0153618 UMLS_CUI:C1335749 carcinoma of kidney Pelvis malignant neoplasm of renal pelvis malignant renal Pelvis neoplasm malignant tumor of renal pelvis renal pelvis cancer disease_ontology DOID:4919 renal pelvis carcinoma NCI:C5559 UMLS_CUI:C1334577 malignant Eccrine tumor malignant eccrine skin neoplasm disease_ontology DOID:4921 eccrine sweat gland cancer A thymic carcinoma that derives_from epithelial cells of glandular origin. NCI:C6459 UMLS_CUI:C1336743 adenocarcinoma of the Thymus disease_ontology DOID:4923 thymus adenocarcinoma An intrahepatic cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts. DOID:5246 GARD:10175 MESH:D018285 NCI:C36077 SNOMEDCT_US_2020_03_01:253017000 UMLS_CUI:C0206702 Klatskin tumor Klatskin tumour Klatskin's tumour Perihilar extrahepatic bile duct carcinoma hilar cholangiocarcinoma hilar cholangiocellular carcinoma disease_ontology DOID:4927 Klatskin's tumor GARD:6042 ICD10CM:C22.1 MESH:D018281 NCI:C35417 SNOMEDCT_US_2020_03_01:109842005 UMLS_CUI:C0345905 Intrahepatic bile duct carcinoma peripheral Cholangiocarcinoma disease_ontology DOID:4928 intrahepatic cholangiocarcinoma An ampulla of Vater cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C3908 SNOMEDCT_US_2020_03_01:254609000 UMLS_CUI:C0262401 ampulla of vater cancer ampullary carcinoma carcinoma of ampulla of vater disease_ontology DOID:4932