BAO
type: Ontology
date: 10 Nov 2022
date: 29 June 2023
date: 8 Jul 2021
date: January 17, 2025
date: March 9, 2023
date: May 12, 2023
date: May 30, 2025
date: October 5, 2025
license: https://creativecommons.org/licenses/by-sa/4.0/
comment: Contact: Stephan Schurer schurer at med dot miami dot edu
comment: Contact: Stephan Schurer stephan dot schurer at gmail dot com
comment: Contact: Stephan Schurer stephan dot schurer at med dot miami dot edu
comment: Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, Nicolette Ross, Joan Glenny-Pescov, Jiaming Hu, Caty Chung, Stephan Schurer*
comment: Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, Stephan Schurer*
comment: Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, add_name, Stephan Schurer*
comment: Created by: Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Saminda Abeyruwan, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner,colette Ross, Joan Glenny-Pescov, Jiaming Hu, Caty Chung, Stephan Schurer*
comment: Created by: Saminda Abeyruwan, Caty Chung, Hande Küçük McGinty, Janice Kranz, Joseph Ostrow, Alex Clark, Yu Lin, Uma Vempati, Kunie Sakurai, Vance Lemmon, Ubbo Visser, John Turner, Nicolette Ross, Joan Glenny-Pescov, Jiaming Hu, Stephan Schurer*
comment: Created by: Caty Chung, Nicolette Ross, Joan Glenny-Pescov, Jiaming Hu, Stephan Schurer*
comment: There is a one-to-one correspondance with rdf:label value and concept descriptions. Concept description starts with the prefix BAO_. contact: Stephan Schurer: stephan dot schurer at gmail dot com
comment: created by: Uma Vempati, Hande Küçük, Ubbo Visser, Saminda Abeyruwan, Kunie Sakurai, Vance Lemmon, Stephan Schurer*
label: BioAssay Ontology
label: Bioassay ontology
label: bioassay ontology
version info: 2.1
version info: 2.7.2
version info: 2.7.4
version info: 2.7.5
version info: 2.8.12
version info: 2.8.15
version info: 2.8.17
version info: 2.8.18
version info: 2.8.2
version info: 2.8.6

LINCS ID
type: AnnotationProperty
textual definition: An annotation property that represents an ID used in the NIH LINCS project.
term editor: Oliver He, Jiangan Xie, Jie Zheng

PubChem AID
type: AnnotationProperty
textual definition: An annotation property that represents a PubMed BioAssay Identifier accession number.
term editor: Oliver He
definition source: https://pubchem.ncbi.nlm.nih.gov/help.html

editor preferred label
type: AnnotationProperty
editor preferred label: editor preferred label
editor preferred label: editor preferred term
has curation status: IAO_0000122
textual definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: editor preferred term
label: editor preferred term~editor preferred label

example of usage
type: AnnotationProperty
editor preferred label: example
editor preferred label: example of usage
has curation status: IAO_0000122
textual definition: A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
textual definition: A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
has cross-reference: IAO:0000112
has_obo_namespace: uberon
id: example_of_usage
is metadata tag: true
shorthand: example_of_usage

has curation status
type: AnnotationProperty
editor preferred label: has curation status
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Bill Bug
term editor: PERSON:Melanie Courtot
definition source: OBI_0000281

textual definition
type: AnnotationProperty
editor preferred label: definition
has curation status: IAO_0000122
textual definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
textual definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
textual definition: The official definition.
textual definition: A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
alternative_term: DEFINITION
label: definition

editor note
type: AnnotationProperty
editor preferred label: editor note
has curation status: IAO_0000122
textual definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
has cross-reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: true
shorthand: editor_note

term editor
type: AnnotationProperty
editor preferred label: term editor
has curation status: IAO_0000122
textual definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

alternative term
type: AnnotationProperty
editor preferred label: alternative term
has curation status: IAO_0000125
textual definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

definition source
type: AnnotationProperty
editor preferred label: definition source
has curation status: IAO_0000122
textual definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
term editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

curator note
type: AnnotationProperty
textual definition: An administrative note of use for a curator but of no use for a user
has cross-reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: true
shorthand: curator_notes
label: curator notes

term tracker item
type: AnnotationProperty
example of usage: the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
textual definition: An IRI or similar locator for a request or discussion of an ontology term.
has cross-reference: IAO:0000233
has_obo_namespace: uberon
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item
comment: The 'tracker item' can associate a tracker with a specific ontology term.

imported from
type: AnnotationProperty
editor preferred label: imported from
has curation status: IAO_0000125
textual definition: For external terms/classes, the ontology from which the term was imported
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

term replaced by
type: AnnotationProperty
has curation status: IAO_0000125
textual definition: Use on obsolete terms, relating the term to another term that can be used as a substitute Add as annotation triples in the granting ontology
term editor: Person:Alan Ruttenberg

Has_PCDC_Data_Type
type: AnnotationProperty
textual definition: An association that specifies one of three data types for a particular variable, String, Code or Number.
code: A23
Semantic_Type: Conceptual Entity
Preferred_Name: Has_PCDC_Data_Type
alternative_term: Has_PCDC_Data_Type

Has_PCDC_EWS_Permissible_Value
type: AnnotationProperty
textual definition: An association that shows which Permissible Values are possible for a specific PCDC EWS Variable concept.
code: A29
Semantic_Type: Conceptual Entity
Preferred_Name: Has_PCDC_EWS_Permissible_Value
alternative_term: Has_PCDC_EWS_Permissible_Value

Is_Value_For_GDC_Property
type: AnnotationProperty
textual definition: An association that that connects a concept representing a GDC value to any associated GDC property concept(s).
code: A32
Semantic_Type: Conceptual Entity
Preferred_Name: Is_Value_For_GDC_Property
alternative_term: Is_Value_For_GDC_Property

Has_PCDC_GCT_Permissible_Value
type: AnnotationProperty
textual definition: An association that shows which Permissible Values are possible for a specific PCDC GCT Variable.
code: A34
Semantic_Type: Conceptual Entity
Preferred_Name: Has_PCDC_GCT_Permissible_Value
alternative_term: Has_PCDC_GCT_Permissible_Value

Has_PCDC_OS_Permissible_Value
type: AnnotationProperty
textual definition: An association that shows which Permissible Values are possible for a specific PCDC OS Variable.
code: A38
Semantic_Type: Conceptual Entity
Preferred_Name: Has_PCDC_OS_Permissible_Value
alternative_term: Has_PCDC_OS_Permissible_Value

Has_PCDC_HL_Permissible_Value
type: AnnotationProperty
textual definition: An association that shows which Permissible Values are possible for a specific PCDC HL Variable.
code: A39
Semantic_Type: Conceptual Entity
Preferred_Name: Has_PCDC_HL_Permissible_Value
alternative_term: Has_PCDC_HL_Permissible_Value

Has_DIPG_DMG_Permissible_Value
type: AnnotationProperty
textual definition: An association that shows which Permissible Values are possible for a specific DIPG/DMG Variable.
code: A40
Semantic_Type: Conceptual Entity
Preferred_Name: Has_DIPG_DMG_Permissible_Value
alternative_term: Has_DIPG_DMG_Permissible_Value

code
type: AnnotationProperty
read only: true
textual definition: A property representing a concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus.
code: NHC0
Semantic_Type: Conceptual Entity
Preferred_Name: code
alternative_term: code

Semantic_Type
type: AnnotationProperty
textual definition: A property that represents a description of the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
code: P106
Semantic_Type: Conceptual Entity
Display_Name: Semantic Type
Preferred_Name: Semantic_Type
DesignNote: In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS.
alternative_term: Semantic_Type

Display_Name
type: AnnotationProperty
textual definition: A property representing an alternative Preferred Name for use in some NCI systems.
code: P107
Semantic_Type: Conceptual Entity
Display_Name: Display Name
Preferred_Name: Display_Name
alternative_term: Display Name
alternative_term: Display_Name

Preferred_Name
type: AnnotationProperty
textual definition: A property representing the word or phrase that NCI uses by preference to refer to the concept.
code: P108
Semantic_Type: Conceptual Entity
Display_Name: Preferred Name
Preferred_Name: Preferred_Name
alternative_term: Preferred Name
alternative_term: Preferred Term
alternative_term: Preferred_Name

UMLS_CUI
type: AnnotationProperty
textual definition: A property representing the concept unique identifier (CUI) assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
code: P207
Semantic_Type: Conceptual Entity
Display_Name: UMLS CUI
Preferred_Name: UMLS_CUI
alternative_term: UMLS_CUI

NCI_META_CUI
type: AnnotationProperty
textual definition: A property representing the concept unique identifier (CUI) for those concepts that appear in NCI Metathesaurus but not in the National Library of Medicine Unified Medical Language System (NLM UMLS).
code: P208
Semantic_Type: Conceptual Entity
Display_Name: NCI Metathesaurus CUI
Preferred_Name: NCI_META_CUI
alternative_term: NCI_META_CUI

Contributing_Source
type: AnnotationProperty
textual definition: A property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake.
code: P322
Semantic_Type: Conceptual Entity
Display_Name: Contributing Source
Preferred_Name: Contributing_Source
alternative_term: Contributing_Source

ALT_DEFINITION
type: AnnotationProperty
textual definition: A property representing the English language definition of a concept from a source other than NCI.
code: P325
Semantic_Type: Conceptual Entity
Display_Name: [source] Definition
Preferred_Name: ALT_DEFINITION
alternative_term: ALT_DEFINITION

Legacy Concept Name
type: AnnotationProperty
read only: true
textual definition: A property representing a retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding.
code: P366
Semantic_Type: Conceptual Entity
Preferred_Name: Legacy Concept Name
alternative_term: Legacy Concept Name
alternative_term: Legacy_Concept_Name

Maps_To
type: AnnotationProperty
textual definition: A property representing that a term in another terminology has been mapped to a term in NCIt and describes the relationship between the mapped terms.
code: P375
Semantic_Type: Conceptual Entity
Preferred_Name: Maps_To
alternative_term: Maps_To

DesignNote
type: AnnotationProperty
textual definition: A property representing notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
code: P98
Semantic_Type: Conceptual Entity
Display_Name: DesignNote
Preferred_Name: DesignNote
alternative_term: DesignNote

IEDB alternative term
type: AnnotationProperty
textual definition: An alternative term used by the IEDB.

never in taxon
type: AnnotationProperty
example of usage: tooth SubClassOf 'never in taxon' value 'Aves'
textual definition: x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
OMO_0002000: PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX never_in_taxon: <http://purl.obolibrary.org/obo/RO_0002161> CONSTRUCT { in_taxon: a owl:ObjectProperty . a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . ?x rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom [ a owl:Class ; owl:complementOf ?taxon ] ] . } WHERE { ?x never_in_taxon: ?taxon . }
has cross-reference: RO:0002161
has_obo_namespace: uberon
id: never_in_taxon
is class level: true
is metadata tag: true
shorthand: never_in_taxon

mutually spatially disjoint with
type: AnnotationProperty
textual definition: A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B.
OMO_0002000: PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX part_of: <http://purl.obolibrary.org/obo/BFO_0000050> PREFIX mutually_spatially_disjoint_with: <http://purl.obolibrary.org/obo/RO_0002171> CONSTRUCT { part_of: a owl:ObjectProperty . [ a owl:Restriction ; owl:onProperty part_of: ; owl:someValuesFrom ?x ; a owl:Restriction ; owl:onProperty part_of: ; owl:someValuesFrom ?y ] ] } WHERE { ?x mutually_spatially_disjoint_with: ?y . }
has cross-reference: RO:0002171
has_obo_namespace: uberon
id: mutually_spatially_disjoint_with
is class level: true
is metadata tag: true
shorthand: mutually_spatially_disjoint_with

present in taxon
type: AnnotationProperty
textual definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
OMO_0002000: PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX present_in_taxon: <http://purl.obolibrary.org/obo/RO_0002175> CONSTRUCT { in_taxon: a owl:ObjectProperty . ?witness rdfs:label ?label . ?witness rdfs:subClassOf ?x . ?witness rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . } WHERE { ?x present_in_taxon: ?taxon . BIND(IRI(CONCAT( "http://purl.obolibrary.org/obo/RO_0002175#", MD5(STR(?x)), "-", MD5(STR(?taxon)) )) as ?witness) BIND(CONCAT(STR(?x), " in taxon ", STR(?taxon)) AS ?label) }
has cross-reference: RO:0002175
has_obo_namespace: uberon
id: present_in_taxon
is class level: true
is metadata tag: true
shorthand: present_in_taxon
comment: The SPARQL expansion for this relation introduces new named classes into the ontology. For this reason it is likely that the expansion should only be performed during a QC pipeline; the expanded output should usually not be included in a published version of the ontology.

is opposite of
type: AnnotationProperty
example of usage: 'anterior end of organism' is-opposite-of 'posterior end of organism'
example of usage: 'increase in temperature' is-opposite-of 'decrease in temperature'
textual definition: x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x).
has cross-reference: RO:0002604
has_obo_namespace: quality
id: is_opposite_of
is class level: true
is metadata tag: true
shorthand: is_opposite_of
label: is_opposite_of

external_definition
type: AnnotationProperty
textual definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
has cross-reference: UBPROP:0000001
has_obo_namespace: uberon
id: external_definition
is metadata tag: true
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

axiom_lost_from_external_ontology
type: AnnotationProperty
textual definition: A textual description of an axiom loss in this ontology compared to an external ontology.
has cross-reference: UBPROP:0000002
has_obo_namespace: uberon
id: axiom_lost_from_external_ontology
is metadata tag: true
shorthand: axiom_lost_from_external_ontology
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

homology_notes
type: AnnotationProperty
textual definition: Notes on the homology status of this class.
has cross-reference: UBPROP:0000003
has_obo_namespace: uberon
id: homology_notes
is metadata tag: true
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

has_relational_adjective
type: AnnotationProperty
curator note: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
has cross-reference: UBPROP:0000007
has_obo_namespace: uberon
id: has_relational_adjective
is metadata tag: true
shorthand: has_relational_adjective

taxon_notes
type: AnnotationProperty
textual definition: Notes on the how instances of this class vary across species.
has cross-reference: UBPROP:0000008
has_obo_namespace: uberon
id: taxon_notes
is metadata tag: true
shorthand: taxon_notes

function_notes
type: AnnotationProperty
textual definition: Notes on the evolved function of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
has cross-reference: UBPROP:0000009
has_obo_namespace: uberon
id: function_notes
is metadata tag: true
shorthand: function_notes

structure_notes
type: AnnotationProperty
textual definition: Notes on the structure, composition or histology of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
has cross-reference: UBPROP:0000010
has_obo_namespace: uberon
id: structure_notes
is metadata tag: true
shorthand: structure_notes

development_notes
type: AnnotationProperty
textual definition: Notes on the ontogenic development of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
has cross-reference: UBPROP:0000011
has_obo_namespace: uberon
id: development_notes
is metadata tag: true
shorthand: development_notes

external_ontology_notes
type: AnnotationProperty
textual definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
has cross-reference: UBPROP:0000012
has_obo_namespace: uberon
id: external_ontology_notes
is metadata tag: true
shorthand: external_ontology_notes

fma_set_term
type: AnnotationProperty
external_ontology_notes: FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term
has cross-reference: UBPROP:0000202
has_obo_namespace: uberon
id: fma_set_term
is metadata tag: true
shorthand: fma_set_term

contributor
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: true
shorthand: dc-contributor

consider
type: AnnotationProperty

created_by
type: AnnotationProperty

creation_date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty
textual definition: An alternative label for a class or property which has a more general meaning than the preferred name/primary label.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/18
label: has broad synonym

has cross-reference
type: AnnotationProperty
example of usage: disease characteristic (MONDO:0021125) has cross-reference (http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C41009"^^xsd:string
textual definition: An annotation property that links an ontology entity or a statement to a prefixed identifier or URI.
textual definition: Reference database or publication source.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/123
contributor: https://orcid.org/0000-0002-7356-1779
label: database_cross_reference

alternative_term
type: AnnotationProperty
textual definition: An alternative label for a class or property which has the exact same meaning than the preferred name/primary label.
textual definition: A property representing a fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
textual definition: An alternative label for a given entity such as a commonly used abbreviation or synonym.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/20
alternative_term: FULL_SYN
alternative_term: Synonym with Source Data
label: has exact synonym
label: has_exact_synonym

has_narrow_synonym
type: AnnotationProperty
textual definition: An alternative label for a class or property which has a more specific meaning than the preferred name/primary label.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/19
label: has narrow synonym

has_obo_namespace
type: AnnotationProperty
textual definition: Name space of the ontology.
comment: disease_ontology

has_related_synonym
type: AnnotationProperty
textual definition: An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/21
label: has related synonym

id
type: AnnotationProperty
textual definition: An identifier for an individual entity.
textual definition: An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity.

in subset
type: AnnotationProperty
textual definition: An association that connects the concept defining a particular terminology subset with concepts that belong to this subset.
alternative_term: Concept_In_Subset
label: in_subset

shorthand
type: AnnotationProperty

comment
type: AnnotationProperty
textual definition: Comment.

rdfs:isDefinedBy
type: AnnotationProperty
textual definition: Is defined by.

label
type: AnnotationProperty
textual definition: A human readable name for this class.

see also
type: AnnotationProperty
has cross-reference: seeAlso
has_obo_namespace: spatial
has_obo_namespace: uberon
id: seeAlso
is metadata tag: true
shorthand: seeAlso

has exact match
type: AnnotationProperty
textual definition: A skos concept mapping used to link two concepts, indicating a high degree of confidence that the concepts can be used interchangeably.

has narrower match
type: AnnotationProperty
textual definition: A skos concept mapping used to state a hierarchical mapping link between two concepts where the DO concept is narrow (DO represents subtypes) and the xref is broad.

depiction
type: AnnotationProperty
has_obo_namespace: uberon
id: depiction
is metadata tag: true
shorthand: depiction

has temperature unit
type: ObjectProperty
sub property of: has unit

has marker
type: ObjectProperty
inverse of: is marker of

is substrate of
type: ObjectProperty
inverse of: has substrate

is marker of
type: ObjectProperty

stains
type: ObjectProperty

has orthogonal assay design
type: ObjectProperty
sub property of: has alternate confirmatory assay
inverse of: is orthogonal assay design of

has response unit
type: ObjectProperty
sub property of: has unit

has concentration unit
type: ObjectProperty
sub property of: has unit

has perturbagen
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is perturbagen of

has mode of action
type: ObjectProperty
sub property of: topObjectProperty

has assay format
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is assay format of

has detection method
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is detection method of

has endpoint
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is endpoint of

has measure group
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is measure group of
domain: BAO_0000015
range: BAO_0000040

has assay stage
type: ObjectProperty
sub property of: topObjectProperty

has target
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is target of

has assay method
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is assay method of

has specification
type: ObjectProperty
sub property of: topObjectProperty
inverse of: is specification of

is orthogonal assay design of
type: ObjectProperty
sub property of: is alternate confirmatory assay of

has assay kit
type: ObjectProperty

has curve fit specification
type: ObjectProperty
sub property of: topObjectProperty

has percent response
type: ObjectProperty
sub property of: topObjectProperty

has concentration
type: ObjectProperty
sub property of: topObjectProperty

is perturbagen of
type: ObjectProperty
sub property of: topObjectProperty

is assay method of
type: ObjectProperty
sub property of: topObjectProperty

has inducer
type: ObjectProperty

is regulated by
type: ObjectProperty
inverse of: is regulator of
property disjoint with: is regulator of

has transcription factor
type: ObjectProperty

is measure group of
type: ObjectProperty
sub property of: topObjectProperty
domain: BAO_0000040
range: BAO_0000015

is related assay to
type: ObjectProperty
sub property of: topObjectProperty
type: SymmetricProperty
type: TransitiveProperty

is confirmatory assay of
type: ObjectProperty
sub property of: is related assay to
inverse of: has confirmatory assay
comment: Assay performed to confirm activity of compounds identified in the primary screen. It can be performed as replicate measurements at a single screening concentration or as concentration-response assay.

is counter assay of
type: ObjectProperty
sub property of: is related assay to
inverse of: has counter assay
comment: Counter assays typically follow concentration-response assays to confirm the biological activity of chemical entities identified in the primary assays. Counter assays eliminate active compounds that do not act on the intended target. They are performed using related targets, e.g. a receptor isoform, a homologous gene, etc which are functionally distinct from the intended target. Counter assays are also performed to eliminate cytotoxic compounds. The actives from the primary assay are tested on cultured cells and the cell death is estimated commonly by measuring ATP concentration. Other example for a counter assays a FRET assay when the primary assay used absorption readout; luminescence readout when the primary assay measured fluorescence intensity, etc.

is identical assay of
type: ObjectProperty
equivalent property: has identical assay
sub property of: is related assay to
type: SymmetricProperty
type: TransitiveProperty
comment: Same target, design, technology, format, but not necessarily the same throughput. For example primary, confirmatory, and concentration-response could be related by 'is identical to'

is alternate assay format of
type: ObjectProperty
sub property of: is alternate confirmatory assay of
inverse of: has alternate assay format

is assay format of
type: ObjectProperty
sub property of: topObjectProperty
domain: BAO_0000019
range: BAO_0000015

is endpoint of
type: ObjectProperty

is regulator of
type: ObjectProperty

is specification of
type: ObjectProperty

has alternate assay format
type: ObjectProperty
sub property of: has alternate confirmatory assay

is target of
type: ObjectProperty

is detection method of
type: ObjectProperty

has manufacturer
type: ObjectProperty

has assay control
type: ObjectProperty

has primary assay
type: ObjectProperty
sub property of: is related assay to
inverse of: is primary assay of

has confirmatory assay
type: ObjectProperty
sub property of: is related assay to

has counter assay
type: ObjectProperty
sub property of: is related assay to

has summary assay
type: ObjectProperty
sub property of: is related assay to
inverse of: is summary assay of

has variant construct assay
type: ObjectProperty
sub property of: has counter assay
inverse of: is variant construct assay of

is variant construct assay of
type: ObjectProperty
sub property of: is counter assay of

has parental cell line assay
type: ObjectProperty
sub property of: has counter assay
inverse of: is parental cell line assay of

is parental cell line assay of
type: ObjectProperty
sub property of: is counter assay of

has compound toxicity assay
type: ObjectProperty
sub property of: has counter assay
inverse of: is compound toxicity assay of

is compound toxicity assay of
type: ObjectProperty
sub property of: is counter assay of

is primary assay of
type: ObjectProperty
sub property of: is related assay to

has selectivity assay
type: ObjectProperty
sub property of: is related assay to
inverse of: is selectivity assay of

is selectivity assay of
type: ObjectProperty
sub property of: is related assay to

has alternate target assay
type: ObjectProperty
sub property of: has counter assay
sub property of: has selectivity assay
inverse of: is alternate target assay of

is alternate target assay of
type: ObjectProperty
sub property of: is counter assay of
sub property of: is selectivity assay of

has alternate cell line assay
type: ObjectProperty
sub property of: has selectivity assay
inverse of: is alternate cell line assay of

is alternate cell line assay of
type: ObjectProperty
sub property of: is selectivity assay of

has alternate organism assay
type: ObjectProperty
sub property of: has selectivity assay
inverse of: is alternate organism assay of

is alternate organism assay of
type: ObjectProperty
sub property of: is selectivity assay of

has alternate confirmatory assay
type: ObjectProperty
sub property of: is related assay to
inverse of: is alternate confirmatory assay of

is alternate confirmatory assay of
type: ObjectProperty
sub property of: is related assay to

has orthogonal assay technology
type: ObjectProperty
sub property of: has alternate confirmatory assay
inverse of: is orthogonal assay technology of

is orthogonal assay technology of
type: ObjectProperty
sub property of: is alternate confirmatory assay of

has alternate assay type
type: ObjectProperty
sub property of: has alternate confirmatory assay
inverse of: is alternate assay type of

is alternate assay type of
type: ObjectProperty
sub property of: is alternate confirmatory assay of

has alternate assay conditions
type: ObjectProperty
sub property of: has alternate confirmatory assay
inverse of: is alternate assay conditions of

is alternate assay conditions of
type: ObjectProperty
sub property of: is alternate confirmatory assay of

has lead optimization assay
type: ObjectProperty
sub property of: is related assay to
inverse of: is lead optimization assay of

is lead optimization assay of
type: ObjectProperty
sub property of: is related assay to

has physicochemical profiling assay
type: ObjectProperty
sub property of: has counter assay
inverse of: is physicochemical profiling assay of

is physicochemical profiling assay of
type: ObjectProperty
sub property of: is counter assay of

has compound fluorescence assay
type: ObjectProperty
sub property of: has physicochemical profiling assay
inverse of: is compound fluorescence assay of

is compound fluorescence assay of
type: ObjectProperty
sub property of: is physicochemical profiling assay of

has compound aggregation assay
type: ObjectProperty
sub property of: has physicochemical profiling assay
inverse of: is compound aggregation assay of

is compound aggregation assay of
type: ObjectProperty
sub property of: is physicochemical profiling assay of

has compound redox-activity assay
type: ObjectProperty
sub property of: has physicochemical profiling assay
inverse of: is compound redox-activity assay of

is compound redox-activity assay of
type: ObjectProperty
sub property of: is physicochemical profiling assay of

is summary assay of
type: ObjectProperty
sub property of: is related assay to

has identical assay
type: ObjectProperty
sub property of: is related assay to
type: SymmetricProperty
type: TransitiveProperty

based on normalization
type: ObjectProperty

has measured entity
type: ObjectProperty
inverse of: is measured entity of

detects
type: ObjectProperty
sub property of: has assay footprint
inverse of: is detected by

catalyzed by
type: ObjectProperty
sub property of: topObjectProperty

has cell line
type: ObjectProperty
inverse of: is cell line of

has form
type: ObjectProperty

involves biological process
type: ObjectProperty

has assay phase characteristic
type: ObjectProperty

is indicator of
type: ObjectProperty

has purity unit
type: ObjectProperty
sub property of: has unit

encodes
type: ObjectProperty

is measured entity of
type: ObjectProperty
sub property of: topObjectProperty

has quality
type: ObjectProperty

uses assay kit
type: ObjectProperty

has assay kit component
type: ObjectProperty

uses as substrate
type: ObjectProperty

has time unit
type: ObjectProperty
sub property of: has unit

has substrate
type: ObjectProperty

is binding site of
type: ObjectProperty
inverse of: has binding site

tagged with
type: ObjectProperty

has detected entity
type: ObjectProperty

is cell line of
type: ObjectProperty

has assay protocol
type: ObjectProperty
inverse of: is assay protocol of

is assay protocol of
type: ObjectProperty

has associated disease
type: ObjectProperty

is associated disease of
type: ObjectProperty

has assay readout content
type: ObjectProperty

has assay readout content parametricity
type: ObjectProperty

has assay source
type: ObjectProperty

has assay title
type: ObjectProperty

has bioassay type
type: ObjectProperty
inverse of: is bioassay type of

is bioassay type of
type: ObjectProperty

has assay readout type
type: ObjectProperty

has signal direction
type: ObjectProperty

has endpoint modifier
type: ObjectProperty

has phenotype
type: ObjectProperty
inverse of: is phenotype of

is phenotype of
type: ObjectProperty

is localized in
type: ObjectProperty

has concentration throughput
type: ObjectProperty

has repetition throughput
type: ObjectProperty

uses detection instrument
type: ObjectProperty

has assay footprint
type: ObjectProperty

silences
type: ObjectProperty

has gene symbol
type: ObjectProperty

is role of
type: ObjectProperty
inverse of: has role

is unit of
type: ObjectProperty
inverse of: has unit

has unit
type: ObjectProperty

is detected by
type: ObjectProperty

has antibody source
type: ObjectProperty

recombinantly expressed in
type: ObjectProperty

has preparation method
type: ObjectProperty

has organism
type: ObjectProperty

has assay medium
type: ObjectProperty

has assay serum
type: ObjectProperty

is grown in
type: ObjectProperty

is transfected into
type: ObjectProperty

has role
type: ObjectProperty

reports
type: ObjectProperty

has binding site
type: ObjectProperty

has function
type: ObjectProperty

involves molecular function
type: ObjectProperty

phenotype of
type: ObjectProperty
inverse of: has phenotype
type: FunctionalProperty

has function in
type: ObjectProperty
textual definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
source: http://www.obofoundry.org/ro/#OBO_REL:part_of

has phenotype
type: ObjectProperty

has part
type: ObjectProperty
type: TransitiveProperty

derives into
type: ObjectProperty
inverse of: derives from

derives from
type: ObjectProperty
comment: See also BFO_0001009

occurs in
type: ObjectProperty
inverse of: contains process
property chain axiom: part of

bearer of
type: ObjectProperty
inverse of: inheres in

inheres in
type: ObjectProperty

contains process
type: ObjectProperty

connected to
type: ObjectProperty
textual definition: X connected_to Y if and only if X and Y share a fiat boundary.

has participant
type: ObjectProperty
inverse of: participates in
source: http://www.obofoundry.org/ro/#OBO_REL:has_participant

participates in
type: ObjectProperty

is derived from
type: ObjectProperty

detects phenotype
type: ObjectProperty

has indicator
type: ObjectProperty

is described by
type: ObjectProperty

quantifies
type: ObjectProperty

has molecular phenotype
type: ObjectProperty
sub property of: has phenotype

has morphological phenotype
type: ObjectProperty
sub property of: has phenotype

has positive control
type: ObjectProperty
sub property of: has assay control

has negative control
type: ObjectProperty
sub property of: has assay control

has experimental setting
type: ObjectProperty

has response value
type: DatatypeProperty

has temperature value
type: DatatypeProperty

has percent response value
type: DatatypeProperty
sub property of: topDataProperty
type: FunctionalProperty
range: float

has id value
type: DatatypeProperty
sub property of: topDataProperty
type: FunctionalProperty
range: Datatype
  union of: integer
  union of: string

has DNA sequence
type: DatatypeProperty
sub property of: has nucleic acid sequence
type: FunctionalProperty
domain: BAO_0000269
range: string

has ID
type: DatatypeProperty
type: FunctionalProperty

has display info
type: DatatypeProperty
sub property of: topDataProperty
type: FunctionalProperty
range: string

has date
type: DatatypeProperty
range: dateTime

has purity value
type: DatatypeProperty

has concentration value
type: DatatypeProperty

has time value
type: DatatypeProperty

has concentration-point number
type: DatatypeProperty

has passage number
type: DatatypeProperty
range: int

has cell count
type: DatatypeProperty

has copy number
type: DatatypeProperty
textual definition: This describes the number of repeats of an entity (e.g., artificial regulatory element, cDNA, etc.) present in a DNA construct.

has gene copy number
type: DatatypeProperty
sub property of: has copy number
textual definition: This describes the number of repeats of a gene of interest cloned in a DNA construct.

has cDNA copy number
type: DatatypeProperty
sub property of: has copy number
textual definition: This describes the number of repeats of a cDNA of interest cloned in a DNA construct.

has artificial regulatory region copy number
type: DatatypeProperty
sub property of: has copy number
textual definition: This describes the number of repeats of an artificial regulatory element present in a DNA construct.

has sequence
type: DatatypeProperty

has protein sequence
type: DatatypeProperty
sub property of: has sequence

has nucleic acid sequence
type: DatatypeProperty
sub property of: has sequence

has RNA sequence
type: DatatypeProperty
sub property of: has nucleic acid sequence

has shRNA sense sequence
type: DatatypeProperty
sub property of: has RNA sequence

has enzyme reaction temperature value
type: DatatypeProperty
sub property of: has assay temperature value
range: int

has sense strand sequence
type: DatatypeProperty
sub property of: has DNA sequence

has anti-sense strand sequence
type: DatatypeProperty
sub property of: has DNA sequence

has assay deposition date
type: DatatypeProperty
sub property of: has date
range: dateTime

has biosafety level
type: DatatypeProperty
range: string
textual definition: A biosafety level is the level of biocontainment required to isolate hazardous biological agents in an enclosed facility. The levels of containment range from the lowest biosafety level of 1 to the highest at level 4. The levels are as follows: BSL1: Suitable for work involving well-characterized agents not known to consistently cause disease in immunocompetent adult humans, and present minimal potential hazard to laboratory personnel and the environment (definition from CDC). BSL2: Suitable for work involving agents that pose moderate hazards to personnel and the environment. It differs from BSL-1 in that 1) laboratory personnel have specific training in handling pathogenic agents and are supervised by scientists competent in handling infectious agents and associated procedures; 2) access to the laboratory is restricted when work is being conducted; and 3) all procedures in which infectious aerosols or splashes may be created are conducted in BSCs or other physical containment equipment (definition from CDC). BSL3: Suitable for clinical, diagnostic, teaching, research, or production facilities where work is performed with indigenous or exotic agents that may cause serious or potentially lethal disease through inhalation route exposure. Laboratory personnel must receive specific training in handling pathogenic and potentially lethal agents, and must be supervised by scientists competent in handling infectious agents and associated procedures. All procedures involving the manipulation of infectious materials must be conducted within BSCs, other physical containment devices, or by personnel wearing appropriate personal protective equipment (definition from CDC). BSL4:

has assay pH value
type: DatatypeProperty
range: float
textual definition: pH approximates the negative logarithm (base 10) of the molar concentration of dissolved hydronium ions in a solution.

has assay pressure value
type: DatatypeProperty
range: float
textual definition: It is the force per unit area applied in a direction perpendicular to the surface of an object in an assay.

has cell modification temperature value
type: DatatypeProperty
sub property of: has assay temperature value
range: int

has perturbagen incubation temperature value
type: DatatypeProperty
sub property of: has assay temperature value
range: int

has substrate incubation temperature value
type: DatatypeProperty
sub property of: has assay temperature value
range: int

has assay temperature value
type: DatatypeProperty
sub property of: topDataProperty
range: int
textual definition: It is the temperature at which the biological experiment was conducted.

has incubation time value
type: DatatypeProperty
sub property of: topDataProperty
range: int
textual definition: It is the interval of time between the addition of a perturbagen, substrate or cell modification and the measurement of change, as observed by a detection method in the bioassay.

has cell modification time value
type: DatatypeProperty
sub property of: has incubation time value
range: int
textual definition: It is the interval of time between the cell modification, namely transient transfection of plasmid DNA/ siRNA, viral transduction, etc and the measurement of change, as observed by a detection method in the bioassay.

has coupled substrate incubation time value
type: DatatypeProperty
sub property of: has incubation time value
range: int

has enzyme reaction time value
type: DatatypeProperty
sub property of: has incubation time value
range: int
textual definition: It is the interval of time between the enzyme activity measurement in a kinetic assay.

has perturbagen incubation time value
type: DatatypeProperty
sub property of: has incubation time value
range: int
textual definition: It is the interval of time between the addition of a perturbagen and the measurement of change, as observed by a detection method in the bioassay.

has substrate incubation time value
type: DatatypeProperty
sub property of: has incubation time value
range: int
textual definition: It is the interval of time between the addition of an enzyme substrate and the measurement of change, as observed by a detection/ readout in a bioassay.

has coupled substrate incubation temperature value
type: DatatypeProperty
sub property of: has assay temperature value
range: int

has repetition point-number
type: DatatypeProperty
range: int
textual definition: The number of replicate measurements (repetitions) per concentration value used.

has wavelength value
type: DatatypeProperty
range: int

is input data value of
type: DatatypeProperty
range: float

has sequence position
type: DatatypeProperty

has shRNA probe sense sequence position
type: DatatypeProperty
sub property of: has sequence position
textual definition: The nucleotide number in the sense strand of a gene that marks the beginning and end of the shRNA probe.

has siRNA probe sense sequence position
type: DatatypeProperty
sub property of: has sequence position
textual definition: The nucleotide number in the sense strand of a gene that marks the beginning and end of the siRNA probe.

has ligand incubation time value
type: DatatypeProperty
sub property of: has incubation time value

has activity threshold value
type: DatatypeProperty
textual definition: The value (in conjunction with the signal direction) used to determine perturbagens of interest (hits.) Perturbagens with a readout value beyond the threshold in the direction of interest are considered active in the assay.

has excitation wavelength value
type: DatatypeProperty
sub property of: has wavelength value

has emission wavelength value
type: DatatypeProperty
sub property of: has wavelength value

has absorbance wavelength value
type: DatatypeProperty
sub property of: has wavelength value

has recommended name
type: DatatypeProperty

has value
type: DatatypeProperty

reports assay measurment value
type: DatatypeProperty

has assay design method
type: DatatypeProperty

has assay supporting method
type: DatatypeProperty

EC 5.4.99.7 (lanosterol synthase) inhibitor
type: Class
subclass of: EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor
textual definition: An EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor that interferes with the action of lanosterol synthase (EC 5.4.99.7).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:101086
in subset: 3 STAR

EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor
type: Class
subclass of: EC 5.4.* (intramolecular transferase) inhibitor
textual definition: An EC 5.4.* (intramolecular transferase) inhibitor that interferes with the activity of any intramolecular transferase transferring other groups (EC 5.4.99.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitors
has_related_synonym: EC 5.4.99.* inhibitor
has_related_synonym: EC 5.4.99.* inhibitors
has_related_synonym: inhibitor of intramolecular transferase transferring other groups
has_related_synonym: inhibitors of intramolecular transferase transferring other groups
has_related_synonym: intramolecular transferase transferring other groups inhibitor
has_related_synonym: intramolecular transferase transferring other groups inhibitors
id: CHEBI:101090
in subset: 3 STAR

zidovudine
type: Class
subclass of: molecular entity
textual definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
imported from: chebi.owl
charge: 0
formula: C10H13N5O4
inchi: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
inchikey: HBOMLICNUCNMMY-XLPZGREQSA-N
mass: 267.24130
monoisotopicmass: 267.09675
smiles: Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
has_alternative_id: CHEBI:619601
has cross-reference: Beilstein:763034
has cross-reference: CAS:30516-87-1
has cross-reference: DrugBank:DB00495
has cross-reference: Drug_Central:2861
has cross-reference: KEGG:C07210
has cross-reference: KEGG:D00413
has cross-reference: LINCS:LSM-5806
has cross-reference: MetaCyc:CPD-15110
has cross-reference: PDBeChem:AZZ
has cross-reference: PMID:19112024
has cross-reference: PMID:26859826
has cross-reference: PMID:29438107
has cross-reference: PMID:9203666
has cross-reference: Patent:US4724232
has cross-reference: Wikipedia:Zidovudine
alternative_term: 3'-azido-3'-deoxythymidine
has_obo_namespace: chebi_ontology
has_related_synonym: AZT
has_related_synonym: Azidothymidine
has_related_synonym: Retrovir
has_related_synonym: Zidovudin
has_related_synonym: Zidovudinum
has_related_synonym: zidovudine
id: CHEBI:10110
in subset: 3 STAR

EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor
type: Class
subclass of: EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor
textual definition: An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitors
has_related_synonym: EC 1.14.11.29 inhibitor
has_related_synonym: EC 1.14.11.29 inhibitors
has_related_synonym: HIF hydroxylase inhibitor
has_related_synonym: HIF hydroxylase inhibitors
has_related_synonym: hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor
has_related_synonym: hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors
has_related_synonym: prolyl 4-hydroxylase inhibitor
has_related_synonym: prolyl 4-hydroxylase inhibitors
id: CHEBI:102248
in subset: 3 STAR

EC 2.6.1.40 [(R)-3-amino-2-methylpropionate--pyruvate transaminase] inhibitor
type: Class
subclass of: EC 2.6.1.* (transaminase) inhibitor
textual definition: An EC 2.6.1.* (transaminase) inhibitor that interferes with the action of (R)-3-amino-2-methylpropionate--pyruvate transaminase (EC 2.6.1.40).
imported from: chebi.owl
has cross-reference: Wikipedia:(R)-3-amino-2-methylpropionate-pyruvate_transaminase
has_obo_namespace: chebi_ontology
has_related_synonym: (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase inhibitor
has_related_synonym: (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase inhibitors
has_related_synonym: (R)-3-amino-2-methylpropionate transaminase inhibitor
has_related_synonym: (R)-3-amino-2-methylpropionate transaminase inhibitors
has_related_synonym: (R)-3-amino-2-methylpropionate--pyruvate aminotransferase inhibitor
has_related_synonym: (R)-3-amino-2-methylpropionate--pyruvate aminotransferase inhibitors
has_related_synonym: D-3-aminoisobutyrate--pyruvate aminotransferase inhibitor
has_related_synonym: D-3-aminoisobutyrate--pyruvate aminotransferase inhibitors
has_related_synonym: D-3-aminoisobutyrate--pyruvate transaminase inhibitor
has_related_synonym: D-3-aminoisobutyrate--pyruvate transaminase inhibitors
has_related_synonym: D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor
has_related_synonym: D-3-aminoisobutyrate-pyruvate aminotransferase inhibitors
has_related_synonym: D-3-aminoisobutyrate-pyruvate transaminase inhibitor
has_related_synonym: D-3-aminoisobutyrate-pyruvate transaminase inhibitors
has_related_synonym: D-AIBAT inhibitor
has_related_synonym: D-AIBAT inhibitors
has_related_synonym: D-beta-aminoisobutyrate:pyruvate aminotransferase inhibitor
has_related_synonym: D-beta-aminoisobutyrate:pyruvate aminotransferase inhibitors
has_related_synonym: EC 2.6.1.40 [(R)-3-amino-2-methylpropionate--pyruvate transaminase] inhibitors
has_related_synonym: EC 2.6.1.40 inhibitor
has_related_synonym: EC 2.6.1.40 inhibitors
has_related_synonym: beta-aminoisobutyrate--pyruvate aminotransferase inhibitor
has_related_synonym: beta-aminoisobutyrate--pyruvate aminotransferase inhibitors
has_related_synonym: beta-aminoisobutyrate--pyruvate transaminase inhibitor
has_related_synonym: beta-aminoisobutyrate--pyruvate transaminase inhibitors
has_related_synonym: beta-aminoisobutyrate-pyruvate aminotransferase inhibitor
has_related_synonym: beta-aminoisobutyrate-pyruvate aminotransferase inhibitors
id: CHEBI:102368
in subset: 3 STAR

EC 2.1.1.8 (histamine N-methyltransferase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of histamine N-methyltransferase (EC 2.1.1.8).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.1.1.8 (histamine N-methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.8 inhibitor
has_related_synonym: EC 2.1.1.8 inhibitors
has_related_synonym: S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitor
has_related_synonym: S-adenosyl-L-methionine:histamine N-tele-methyltransferase inhibitors
has_related_synonym: S-adenosylmethionine-histamine N-methyltransferase inhibitor
has_related_synonym: S-adenosylmethionine-histamine N-methyltransferase inhibitors
has_related_synonym: histamine 1-methyltransferase inhibitor
has_related_synonym: histamine 1-methyltransferase inhibitors
has_related_synonym: histamine methyltransferase inhibitor
has_related_synonym: histamine methyltransferase inhibitors
has_related_synonym: histamine-methylating enzyme inhibitor
has_related_synonym: histamine-methylating enzyme inhibitors
has_related_synonym: imidazolemethyltransferase inhibitor
has_related_synonym: imidazolemethyltransferase inhibitors
id: CHEBI:110725
in subset: 3 STAR

calmodulin antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin.
imported from: chebi.owl
has cross-reference: PMID:26717596
has_obo_namespace: chebi_ontology
id: CHEBI:130181
in subset: 3 STAR

IP3 receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates IP3 receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Inositol_trisphosphate_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: D-myo-inositol 1,4,5-trisphosphate receptor antagonist
has_related_synonym: D-myo-inositol 1,4,5-trisphosphate receptor antagonists
has_related_synonym: IP3 antagonist
has_related_synonym: IP3 antagonists
has_related_synonym: IP3 receptor antagonists
has_related_synonym: InsP3R antagonist
has_related_synonym: InsP3R antagonists
has_related_synonym: inositol trisphosphate receptor antagonist
has_related_synonym: inositol trisphosphate receptor antagonists
id: CHEBI:131186
in subset: 3 STAR

adenosine A2B receptor agonist
type: Class
subclass of: adenosine receptor agonist
textual definition: An agonist at the A2B receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: A2B agonist
has_related_synonym: A2B agonists
has_related_synonym: A2B receptor agonist
has_related_synonym: A2B receptor agonists
has_related_synonym: adenosine A2B receptor agonists
id: CHEBI:131359
in subset: 3 STAR

Wnt signalling activator
type: Class
subclass of: activator
textual definition: A substance that activates any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
imported from: chebi.owl
has cross-reference: Wikipedia:Wnt_signaling_pathway
has_obo_namespace: chebi_ontology
has_related_synonym: Wnt signaling activator
has_related_synonym: Wnt signaling activators
has_related_synonym: Wnt signalling activators
id: CHEBI:131492
in subset: 3 STAR

formyl peptide receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates formyl peptide receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Formyl_peptide_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: FPR agonist
has_related_synonym: FPR agonists
has_related_synonym: formyl peptide receptor agonists
id: CHEBI:131495
in subset: 3 STAR

EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor
type: Class
subclass of: EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of lysine-specific histone demethylase 1A (EC 1.14.99.66).
imported from: chebi.owl
has cross-reference: Wikipedia:KDM1A
has_obo_namespace: chebi_ontology
has_related_synonym: AOF2 inhibitor
has_related_synonym: AOF2 inhibitors
has_related_synonym: BHC110 inhibitor
has_related_synonym: BHC110 inhibitors
has_related_synonym: CPRF inhibitor
has_related_synonym: CPRF inhibitors
has_related_synonym: EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitors
has_related_synonym: EC 1.14.99.66 inhibitor
has_related_synonym: EC 1.14.99.66 inhibitors
has_related_synonym: KDM1A inhibitor
has_related_synonym: KDM1A inhibitors
has_related_synonym: KIAA0601 inhibitor
has_related_synonym: KIAA0601 inhibitors
has_related_synonym: LSD1 inhibitor
has_related_synonym: LSD1 inhibitors
has_related_synonym: [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitor
has_related_synonym: [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitors
has_related_synonym: amine oxidase (flavin containing) domain 2 inhibitor
has_related_synonym: amine oxidase (flavin containing) domain 2 inhibitors
has_related_synonym: lysine (K)-specific demethylase 1A inhibitor
has_related_synonym: lysine (K)-specific demethylase 1A inhibitors
has_related_synonym: lysine demethylase 1A inhibitor
has_related_synonym: lysine demethylase 1A inhibitors
has_related_synonym: lysine-specific demethylase 1A inhibitor
has_related_synonym: lysine-specific demethylase 1A inhibitors
has_related_synonym: lysine-specific histone demethylase 1A inhibitor
has_related_synonym: lysine-specific histone demethylase 1A inhibitors
id: CHEBI:131509
in subset: 3 STAR

hyaluronic acid synthesis inhibitor
type: Class
subclass of: inhibitor
textual definition: Any compound that inhibits one or more steps in the pathway leading to the synthesis of hyaluronic acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: HA inhibitor
has_related_synonym: HA inhibitors
has_related_synonym: HA synthesis inhibitor
has_related_synonym: HA synthesis inhibitors
has_related_synonym: hyaluronic acid inhibitor
has_related_synonym: hyaluronic acid inhibitors
has_related_synonym: hyaluronic acid synthesis inhibitors
id: CHEBI:131561
in subset: 3 STAR

Mycoplasma genitalium metabolite
type: Class
subclass of: bacterial metabolite
textual definition: Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Mycoplasma genitalium metabolites
id: CHEBI:131604
in subset: 3 STAR

teichoic acid biosynthesis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any compound that inhibits the biosynthesis of teichoic acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: TarO inhibitor
has_related_synonym: TarO inhibitors
has_related_synonym: teichoic acid biosynthesis inhibitors
id: CHEBI:131611
in subset: 3 STAR

EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor
type: Class
subclass of: DNA polymerase inhibitor
textual definition: A DNA polymerase inhibitor that interferes with the action of a DNA-directed DNA polymerase (EC 2.7.7.7).
imported from: chebi.owl
has cross-reference: Wikipedia:DNA_polymerase
has_obo_namespace: chebi_ontology
has_related_synonym: DNA duplicase inhibitor
has_related_synonym: DNA duplicase inhibitors
has_related_synonym: DNA nucleotidyltransferase (DNA-directed) inhibitor
has_related_synonym: DNA nucleotidyltransferase (DNA-directed) inhibitors
has_related_synonym: DNA nucleotidyltransferase inhibitor
has_related_synonym: DNA nucleotidyltransferase inhibitors
has_related_synonym: DNA polymerase I inhibitor
has_related_synonym: DNA polymerase I inhibitors
has_related_synonym: DNA polymerase II inhibitor
has_related_synonym: DNA polymerase II inhibitors
has_related_synonym: DNA polymerase III inhibitor
has_related_synonym: DNA polymerase III inhibitors
has_related_synonym: DNA polymerase alpha inhibitor
has_related_synonym: DNA polymerase alpha inhibitors
has_related_synonym: DNA polymerase beta inhibitor
has_related_synonym: DNA polymerase beta inhibitors
has_related_synonym: DNA polymerase gamma inhibitor
has_related_synonym: DNA polymerase gamma inhibitors
has_related_synonym: DNA polymerase inhibitor
has_related_synonym: DNA polymerase inhibitors
has_related_synonym: DNA replicase inhibitor
has_related_synonym: DNA replicase inhibitors
has_related_synonym: DNA-dependent DNA polymerase inhibitor
has_related_synonym: DNA-dependent DNA polymerase inhibitors
has_related_synonym: DNA-directed DNA polymerase (EC 2.7.7.7) inhibitor
has_related_synonym: DNA-directed DNA polymerase (EC 2.7.7.7) inhibitors
has_related_synonym: EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitors
has_related_synonym: EC 2.7.7.7 inhibitor
has_related_synonym: EC 2.7.7.7 inhibitors
has_related_synonym: Klenow fragment inhibitor
has_related_synonym: Klenow fragment inhibitors
has_related_synonym: Taq DNA polymerase inhibitor
has_related_synonym: Taq DNA polymerase inhibitors
has_related_synonym: Taq Pol I inhibitor
has_related_synonym: Taq Pol I inhibitors
has_related_synonym: Tca DNA polymerase inhibitor
has_related_synonym: Tca DNA polymerase inhibitors
has_related_synonym: deoxynucleate polymerase inhibitor
has_related_synonym: deoxynucleate polymerase inhibitors
has_related_synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) inhibitor
has_related_synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) inhibitors
has_related_synonym: deoxyribonucleate nucleotidyltransferase inhibitor
has_related_synonym: deoxyribonucleate nucleotidyltransferase inhibitors
has_related_synonym: deoxyribonucleic acid duplicase inhibitor
has_related_synonym: deoxyribonucleic acid duplicase inhibitors
has_related_synonym: deoxyribonucleic acid polymerase inhibitor
has_related_synonym: deoxyribonucleic acid polymerase inhibitors
has_related_synonym: deoxyribonucleic duplicase inhibitor
has_related_synonym: deoxyribonucleic duplicase inhibitors
has_related_synonym: deoxyribonucleic polymerase I inhibitor
has_related_synonym: deoxyribonucleic polymerase I inhibitors
has_related_synonym: deoxyribonucleic polymerase inhibitor
has_related_synonym: deoxyribonucleic polymerase inhibitors
has_related_synonym: duplicase inhibitor
has_related_synonym: duplicase inhibitors
has_related_synonym: sequenase inhibitor
has_related_synonym: sequenase inhibitors
id: CHEBI:131699
in subset: 3 STAR

EC 2.7.11.20 (elongation factor 2 kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: Any EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of elongation factor 2 kinase (EC 2.7.11.20).
imported from: chebi.owl
has cross-reference: Wikipedia:Elongation_factor_2_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:[elongation factor 2] phosphotransferase inhibitor
has_related_synonym: ATP:[elongation factor 2] phosphotransferase inhibitors
has_related_synonym: Ca/CaM-kinase III inhibitor
has_related_synonym: Ca/CaM-kinase III inhibitors
has_related_synonym: CaM kinase III inhibitor
has_related_synonym: CaM kinase III inhibitors
has_related_synonym: EC 2.7.11.20 (elongation factor 2 kinase) inhibitors
has_related_synonym: EC 2.7.11.20 inhibitor
has_related_synonym: EC 2.7.11.20 inhibitors
has_related_synonym: EF2K inhibitor
has_related_synonym: EF2K inhibitors
has_related_synonym: STK19 inhibitor
has_related_synonym: STK19 inhibitors
has_related_synonym: calmodulin-dependent protein kinase III inhibitor
has_related_synonym: calmodulin-dependent protein kinase III inhibitors
has_related_synonym: eEF2 kinase inhibitor
has_related_synonym: eEF2 kinase inhibitors
has_related_synonym: eEF2K inhibitor
has_related_synonym: eEF2K inhibitors
has_related_synonym: elongation factor 2 kinase (EC 2.7.11.20) inhibitor
has_related_synonym: elongation factor 2 kinase (EC 2.7.11.20) inhibitors
has_related_synonym: elongation factor 2 kinase inhibitor
has_related_synonym: elongation factor 2 kinase inhibitors
id: CHEBI:131734
in subset: 3 STAR

EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
textual definition: A EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of channel-conductance-controlling ATPase (EC 3.6.3.49, also known as cystic fibrosis conductance regulator, CFCR).
imported from: chebi.owl
has_alternative_id: CHEBI:131771
has cross-reference: Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator
has_obo_namespace: chebi_ontology
has_related_synonym: ATP phosphohydrolase (channel-conductance-controlling) inhibitor
has_related_synonym: ATP phosphohydrolase (channel-conductance-controlling) inhibitors
has_related_synonym: CFTR inhibitor
has_related_synonym: CFTR inhibitors
has_related_synonym: EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitors
has_related_synonym: EC 3.6.3.49 inhibitor
has_related_synonym: EC 3.6.3.49 inhibitors
has_related_synonym: channel-conductance-controlling ATPase (EC 3.6.3.49) inhibitor
has_related_synonym: channel-conductance-controlling ATPase (EC 3.6.3.49) inhibitors
has_related_synonym: channel-conductance-controlling ATPase inhibitor
has_related_synonym: channel-conductance-controlling ATPase inhibitors
has_related_synonym: cystic fibrosis conductance regulator inhibitor
has_related_synonym: cystic fibrosis conductance regulator inhibitors
has_related_synonym: cystic fibrosis transmembrane conductance regulator inhibitor
has_related_synonym: cystic fibrosis transmembrane conductance regulator inhibitors
has_related_synonym: cystic-fibrosis membrane-conductance-regulating protein inhibitor
has_related_synonym: cystic-fibrosis membrane-conductance-regulating protein inhibitors
id: CHEBI:131770
in subset: 3 STAR

dopamine receptor D2 antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates the dopamine receptor D2, the main receptor for all antipsychotic drugs.
imported from: chebi.owl
has cross-reference: PMID:23323533
has cross-reference: Wikipedia:Dopamine_receptor_D2
has_obo_namespace: chebi_ontology
has_related_synonym: D2 receptor antagonist
has_related_synonym: D2R antagonist
id: CHEBI:131787
in subset: 3 STAR

RUNX1 inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor that interferes with RUNX1 (runt-related transcription factor 1), a transcription factor protein that regulates the differentiation of haematopoietic stem cells into mature blood cells.
imported from: chebi.owl
has cross-reference: Wikipedia:RUNX1
has_obo_namespace: chebi_ontology
has_related_synonym: AML1 inhibitor
has_related_synonym: AML1 inhibitors
has_related_synonym: CBFA2 inhibitor
has_related_synonym: CBFA2 inhibitors
has_related_synonym: RUNX1 inhibitors
has_related_synonym: acute myeloid leukemia 1 protein inhibitor
has_related_synonym: acute myeloid leukemia 1 protein inhibitors
has_related_synonym: core-binding factor subunit alpha-2 inhibitor
has_related_synonym: core-binding factor subunit alpha-2 inhibitors
has_related_synonym: core-binding factor subunit alpha2 inhibitor
has_related_synonym: core-binding factor subunit alpha2 inhibitors
has_related_synonym: runt-related transcription factor 1 inhibitor
has_related_synonym: runt-related transcription factor 1 inhibitors
id: CHEBI:131789
in subset: 3 STAR

melatonin receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates melatonin receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Melatonin_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: melatonin receptor antagonists
id: CHEBI:131790
in subset: 3 STAR

HIV-1 Tat inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor of gene expression of human immunodeficiency virus type 1 (HIV-1) at the transcriptional level through interference with Tat-mediated transactivation.
imported from: chebi.owl
has cross-reference: PMID:11747436
has cross-reference: PMID:7650672
has cross-reference: PMID:8410982
has cross-reference: PMID:9548739
has cross-reference: Wikipedia:Tat_(HIV)
has_obo_namespace: chebi_ontology
has_related_synonym: HIV-1 Tat antagonist
has_related_synonym: HIV-1 Tat antagonists
has_related_synonym: HIV-1 Tat inhibitors
has_related_synonym: HIV-1 trans-activator of transcription antagonist
has_related_synonym: HIV-1 trans-activator of transcription antagonists
has_related_synonym: human immunodeficiency virus type 1 Tat antagonist
has_related_synonym: human immunodeficiency virus type 1 Tat antagonists
has_related_synonym: human immunodeficiency virus type 1 Tat inhibitor
has_related_synonym: human immunodeficiency virus type 1 Tat inhibitors
has_related_synonym: human immunodeficiency virus type 1 trans-activator of transcription antagonist
has_related_synonym: human immunodeficiency virus type 1 trans-activator of transcription antagonists
id: CHEBI:131791
in subset: 3 STAR

EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: Any EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of a Ca(2+)/calmodulin-dependent protein kinase (EC 2.7.11.17).
imported from: chebi.owl
has cross-reference: Wikipedia:CAMK
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:caldesmon O-phosphotransferase inhibitor
has_related_synonym: ATP:caldesmon O-phosphotransferase inhibitors
has_related_synonym: ATP:protein phosphotransferase ((2+)/calmodulin-dependent) inhibitor
has_related_synonym: ATP:protein phosphotransferase ((2+)/calmodulin-dependent) inhibitors
has_related_synonym: CAM PKII inhibitor
has_related_synonym: CAM PKII inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase (EC 2.7.11.17) inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase (EC 2.7.11.17) inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase 1 inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase 1 inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase II inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase II inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase IV inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase IV inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase kinase beta inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase kinase beta inhibitors
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase kinase inhibitor
has_related_synonym: Ca(2+)/calmodulin-dependent protein kinase kinase inhibitors
has_related_synonym: CaM kinase II inhibitor
has_related_synonym: CaM kinase II inhibitors
has_related_synonym: CaM kinase inhibitor
has_related_synonym: CaM kinase inhibitors
has_related_synonym: CaM-regulated serine/threonine kinase inhibitor
has_related_synonym: CaM-regulated serine/threonine kinase inhibitors
has_related_synonym: CaMKI inhibitor
has_related_synonym: CaMKI inhibitors
has_related_synonym: CaMKII inhibitor
has_related_synonym: CaMKII inhibitors
has_related_synonym: CaMKIV inhibitor
has_related_synonym: CaMKIV inhibitors
has_related_synonym: CaMKKalpha inhibitor
has_related_synonym: CaMKKalpha inhibitors
has_related_synonym: CaMKKbeta inhibitor
has_related_synonym: CaMKKbeta inhibitors
has_related_synonym: EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitors
has_related_synonym: EC 2.7.11.17 inhibitor
has_related_synonym: EC 2.7.11.17 inhibitors
has_related_synonym: STK20 inhibitor
has_related_synonym: STK20 inhibitors
has_related_synonym: caldesmon kinase (phosphorylating) inhibitor
has_related_synonym: caldesmon kinase (phosphorylating) inhibitors
has_related_synonym: caldesmon kinase inhibitor
has_related_synonym: caldesmon kinase inhibitors
has_related_synonym: calmodulin-dependent kinase II inhibitor
has_related_synonym: calmodulin-dependent kinase II inhibitors
has_related_synonym: microtubule-associated protein 2 kinase inhibitor
has_related_synonym: microtubule-associated protein 2 kinase inhibitors
id: CHEBI:131794
in subset: 3 STAR

dopamine receptor D1 agonist
type: Class
subclass of: dopamine agonist
textual definition: A dopamine agonist that binds to and activates the dopamine receptor D1.
imported from: chebi.owl
has cross-reference: Wikipedia:Dopamine_receptor_D1
has_obo_namespace: chebi_ontology
has_related_synonym: D1 agonist
has_related_synonym: D1 agonists
has_related_synonym: dopamine D1 receptor agonist
has_related_synonym: dopamine D1 receptor agonists
has_related_synonym: dopamine receptor D1 agonists
id: CHEBI:131795
in subset: 3 STAR

SMO receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that enhances the action of smoothened (SMO) receptor.
imported from: chebi.owl
has cross-reference: PMID:12437772
has cross-reference: PMID:20439738
has cross-reference: Wikipedia:Smoothened
has_obo_namespace: chebi_ontology
has_related_synonym: SMO receptor agonists
has_related_synonym: smoothened agonist
has_related_synonym: smoothened agonists
has_related_synonym: smoothened receptor agonist
has_related_synonym: smoothened receptor agonists
id: CHEBI:131809
in subset: 3 STAR

EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor
type: Class
subclass of: EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor
textual definition: An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of gamma-butyrobetaine dioxygenase (EC 1.14.11.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Gamma-butyrobetaine_dioxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) inhibitor
has_related_synonym: 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) inhibitors
has_related_synonym: BBOX inhibitor
has_related_synonym: BBOX inhibitors
has_related_synonym: EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitors
has_related_synonym: EC 1.14.11.1 inhibitor
has_related_synonym: EC 1.14.11.1 inhibitors
has_related_synonym: alpha-butyrobetaine hydroxylase inhibitor
has_related_synonym: alpha-butyrobetaine hydroxylase inhibitors
has_related_synonym: butyrobetaine hydroxylase inhibitor
has_related_synonym: butyrobetaine hydroxylase inhibitors
has_related_synonym: gamma-butyrobetaine hydroxylase inhibitor
has_related_synonym: gamma-butyrobetaine hydroxylase inhibitors
id: CHEBI:131844
in subset: 3 STAR

EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor
type: Class
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
textual definition: An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor that interferes with the action of tryptophan 2,3-dioxygenase (EC 1.13.11.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Tryptophan_2,3-dioxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitors
has_related_synonym: EC 1.13.11.11 inhibitor
has_related_synonym: EC 1.13.11.11 inhibitors
has_related_synonym: L-tryptophan 2,3-dioxygenase inhibitor
has_related_synonym: L-tryptophan 2,3-dioxygenase inhibitors
has_related_synonym: L-tryptophan pyrrolase inhibitor
has_related_synonym: L-tryptophan pyrrolase inhibitors
has_related_synonym: L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitor
has_related_synonym: L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitors
has_related_synonym: L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) inhibitor
has_related_synonym: L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) inhibitors
has_related_synonym: TDO inhibitor
has_related_synonym: TDO inhibitors
has_related_synonym: indolamine 2,3-dioxygenase inhibitor
has_related_synonym: indolamine 2,3-dioxygenase inhibitors
has_related_synonym: indoleamine 2,3-dioxygenase inhibitor
has_related_synonym: indoleamine 2,3-dioxygenase inhibitors
has_related_synonym: tryptamin 2,3-dioxygenase inhibitor
has_related_synonym: tryptamin 2,3-dioxygenase inhibitors
has_related_synonym: tryptamine 2,3-dioxygenase inhibitor
has_related_synonym: tryptamine 2,3-dioxygenase inhibitors
has_related_synonym: tryptophan 2,3-dioxygenase (EC 1.13.11.11) inhibitor
has_related_synonym: tryptophan 2,3-dioxygenase (EC 1.13.11.11) inhibitors
has_related_synonym: tryptophan 2,3-dioxygenase inhibitor
has_related_synonym: tryptophan 2,3-dioxygenase inhibitors
has_related_synonym: tryptophan oxygenase inhibitor
has_related_synonym: tryptophan oxygenase inhibitors
has_related_synonym: tryptophan peroxidase inhibitor
has_related_synonym: tryptophan peroxidase inhibitors
has_related_synonym: tryptophan pyrrolase inhibitor
has_related_synonym: tryptophan pyrrolase inhibitors
has_related_synonym: tryptophanase inhibitor
has_related_synonym: tryptophanase inhibitors
id: CHEBI:131961
in subset: 3 STAR

herbicide safener
type: Class
subclass of: agrochemical
textual definition: A compound used with herbicides that reduces the effect of the herbicide on crop plants or otherwise improves the selectivity of the herbicide for weed species over the crop plant.
imported from: chebi.owl
has cross-reference: PMID:12222792
has cross-reference: PMID:23564986
has cross-reference: Wikipedia:Herbicide_safener
has_obo_namespace: chebi_ontology
has_related_synonym: herbicide safeners
id: CHEBI:132272
in subset: 3 STAR

EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor
type: Class
subclass of: EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor
textual definition: An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of procollagen-proline dioxygenase (EC 1.14.11.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Procollagen-proline_dioxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitors
has_related_synonym: EC 1.14.11.2 inhibitor
has_related_synonym: EC 1.14.11.2 inhibitors
has_related_synonym: collagen proline hydroxylase inhibitor
has_related_synonym: collagen proline hydroxylase inhibitors
has_related_synonym: hydroxylase, collagen proline inhibitor
has_related_synonym: hydroxylase, collagen proline inhibitors
has_related_synonym: peptidyl proline hydroxylase inhibitor
has_related_synonym: peptidyl proline hydroxylase inhibitors
has_related_synonym: procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor
has_related_synonym: procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors
has_related_synonym: procollagen-proline 4-dioxygenase inhibitor
has_related_synonym: procollagen-proline 4-dioxygenase inhibitors
has_related_synonym: procollagen-proline dioxygenase (EC 1.14.11.2) inhibitor
has_related_synonym: procollagen-proline dioxygenase (EC 1.14.11.2) inhibitors
has_related_synonym: procollagen-proline dioxygenase inhibitor
has_related_synonym: procollagen-proline dioxygenase inhibitors
has_related_synonym: procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitor
has_related_synonym: procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitors
has_related_synonym: proline hydroxylase inhibitor
has_related_synonym: proline hydroxylase inhibitors
has_related_synonym: proline protocollagen hydroxylase inhibitor
has_related_synonym: proline protocollagen hydroxylase inhibitors
has_related_synonym: proline, 2-oxoglutarate dioxygenase inhibitor
has_related_synonym: proline, 2-oxoglutarate dioxygenase inhibitors
has_related_synonym: proline,2-oxoglutarate 4-dioxygenase inhibitor
has_related_synonym: proline,2-oxoglutarate 4-dioxygenase inhibitors
has_related_synonym: prolyl 4-hydroxylase inhibitor
has_related_synonym: prolyl 4-hydroxylase inhibitors
has_related_synonym: prolyl hydroxylase inhibitor
has_related_synonym: prolyl hydroxylase inhibitors
has_related_synonym: prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitor
has_related_synonym: prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitors
has_related_synonym: prolylprotocollagen dioxygenase inhibitor
has_related_synonym: prolylprotocollagen dioxygenase inhibitors
has_related_synonym: prolylprotocollagen hydroxylase inhibitor
has_related_synonym: prolylprotocollagen hydroxylase inhibitors
has_related_synonym: protocollagen hydroxylase inhibitor
has_related_synonym: protocollagen hydroxylase inhibitors
has_related_synonym: protocollagen proline 4-hydroxylase inhibitor
has_related_synonym: protocollagen proline 4-hydroxylase inhibitors
has_related_synonym: protocollagen proline dioxygenase inhibitor
has_related_synonym: protocollagen proline dioxygenase inhibitors
has_related_synonym: protocollagen proline hydroxylase inhibitor
has_related_synonym: protocollagen proline hydroxylase inhibitors
has_related_synonym: protocollagen prolyl hydroxylase inhibitor
has_related_synonym: protocollagen prolyl hydroxylase inhibitors
id: CHEBI:132365
in subset: 3 STAR

EC 3.2.1.23 (beta-galactosidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of beta-galactosidase (EC 3.2.1.23).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.23 (beta-galactosidase) inhibitors
has_related_synonym: EC 3.2.1.23 inhibitor
has_related_synonym: EC 3.2.1.23 inhibitors
has_related_synonym: S 2107 inhibitor
has_related_synonym: S 2107 inhibitors
has_related_synonym: beta-D-galactanase inhibitor
has_related_synonym: beta-D-galactanase inhibitors
has_related_synonym: beta-D-galactoside galactohydrolase inhibitor
has_related_synonym: beta-D-galactoside galactohydrolase inhibitors
has_related_synonym: beta-D-lactosidase inhibitor
has_related_synonym: beta-D-lactosidase inhibitors
has_related_synonym: beta-lactosidase inhibitor
has_related_synonym: beta-lactosidase inhibitors
has_related_synonym: exo-(1->4)-beta-D-galactanase inhibitor
has_related_synonym: exo-(1->4)-beta-D-galactanase inhibitors
has_related_synonym: hydrolact inhibitor
has_related_synonym: hydrolact inhibitors
has_related_synonym: lactase inhibitor
has_related_synonym: lactase inhibitors
has_related_synonym: lactozym inhibitor
has_related_synonym: lactozym inhibitors
has_related_synonym: maxilact inhibitor
has_related_synonym: maxilact inhibitors
has_related_synonym: oryzatym inhibitor
has_related_synonym: oryzatym inhibitors
has_related_synonym: sumiklat inhibitor
has_related_synonym: sumiklat inhibitors
has_related_synonym: trilactase inhibitor
has_related_synonym: trilactase inhibitors
id: CHEBI:132518
in subset: 3 STAR

TRPM4 channel inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor of transient receptor potential cation channel subfamily M member 4.
imported from: chebi.owl
has cross-reference: Wikipedia:TRPM4
has_obo_namespace: chebi_ontology
has_related_synonym: TRPM4 channel inhibitors
has_related_synonym: Transient receptor potential cation channel subfamily M member 4 inhibitor
has_related_synonym: Transient receptor potential cation channel subfamily M member 4 inhibitors
has_related_synonym: melastatin 4 inhibitor
has_related_synonym: melastatin 4 inhibitors
id: CHEBI:132608
in subset: 3 STAR

xenoantigen
type: Class
subclass of: antigen
textual definition: An antigen that is found in more than one species.
imported from: chebi.owl
has cross-reference: PMID:25605448
has cross-reference: PMID:26572140
has cross-reference: PMID:26978574
has cross-reference: PMID:27154491
has cross-reference: PMID:27379553
has_obo_namespace: chebi_ontology
has_related_synonym: xenoantigens
id: CHEBI:132710
in subset: 3 STAR

bleaching agent
type: Class
subclass of: reagent
textual definition: A reagent that lightens or whitens a substrate through chemical reaction. Bleaching reactions usually involve oxidative or reductive processes that degrade colour systems. Bleaching can occur by destroying one or more of the double bonds in the conjugated chain, by cleaving the conjugated chain, or by oxidation of one of the other moieties in the conjugated chain. Their reactivity results in many bleaches having strong bactericidal, disinfecting, and sterilising properties.
imported from: chebi.owl
has cross-reference: Wikipedia:Bleach
has_obo_namespace: chebi_ontology
id: CHEBI:132717
in subset: 3 STAR

EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor
type: Class
subclass of: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
textual definition: Any EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme acting on GTP that is involved in cellular and subcellular movement (EC 3.6.5.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitors
id: CHEBI:132771
in subset: 3 STAR

EC 3.6.5.5 (dynamin GTPase) inhibitor
type: Class
subclass of: EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor
textual definition: An EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor that interferes with the action of dynamin GTPase (EC 3.6.5.5).
imported from: chebi.owl
has cross-reference: Wikipedia:Dynamin
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.6.5.5 (dynamin GTPase) inhibitors
has_related_synonym: EC 3.6.5.5 inhibitor
has_related_synonym: EC 3.6.5.5 inhibitors
has_related_synonym: GTP phosphohydrolase (vesicle-releasing) inhibitor
has_related_synonym: GTP phosphohydrolase (vesicle-releasing) inhibitors
has_related_synonym: dynamin GTPase (EC 3.6.5.5) inhibitor
has_related_synonym: dynamin GTPase (EC 3.6.5.5) inhibitors
has_related_synonym: dynamin GTPase inhibitor
has_related_synonym: dynamin GTPase inhibitors
id: CHEBI:132772
in subset: 3 STAR

farnesoid X receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates farnesoid X receptors
imported from: chebi.owl
has cross-reference: Wikipedia:Farnesoid_X_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: BAR agonist
has_related_synonym: BAR agonists
has_related_synonym: FXR agonist
has_related_synonym: FXR agonists
has_related_synonym: bile acid receptor agonist
has_related_synonym: bile acid receptor agonists
has_related_synonym: farnesoid X receptor agonists
id: CHEBI:132972
in subset: 3 STAR

radiosensitizing agent
type: Class
subclass of: drug
textual definition: A drug that makes increases the sensitivity of tumour cells to radiation therapy.
imported from: chebi.owl
has cross-reference: PMID:12520460
has cross-reference: Wikipedia:Radiosensitizer
has_obo_namespace: chebi_ontology
has_related_synonym: radiosensitiser
has_related_synonym: radiosensitisers
has_related_synonym: radiosensitising agent
has_related_synonym: radiosensitising agents
has_related_synonym: radiosensitizer
has_related_synonym: radiosensitizers
has_related_synonym: radiosensitizing agents
id: CHEBI:132992
in subset: 3 STAR

5-hydroxytryptamine 2A receptor inverse agonist
type: Class
subclass of: inverse agonist
textual definition: An inverse agonist that binds to the same receptor as a 5-hydroxytryptamine 2A receptor agonist, but which induces a pharmacological response opposite to that agonist.
imported from: chebi.owl
has cross-reference: Wikipedia:5-HT2A_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: 5-hydroxytryptamine (2A) receptor inverse agonist
has_related_synonym: 5-hydroxytryptamine (2A) receptor inverse agonists
has_related_synonym: 5-hydroxytryptamine 2A receptor inverse agonists
has_related_synonym: 5HT(2A) inverse agonist
has_related_synonym: 5HT(2A) inverse agonists
has_related_synonym: 5HT2A inverse agonists
has_related_synonym: 5HT2Ainverse agonist
id: CHEBI:133016
in subset: 3 STAR

B-cell lymphoma 2 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of B-cell lymphoma 2 protein.
imported from: chebi.owl
has cross-reference: Wikipedia:Bcl-2
has_obo_namespace: chebi_ontology
has_related_synonym: B-cell lymphoma 2 inhibitors
has_related_synonym: Bcl-2 inhibitor
has_related_synonym: Bcl-2 inhibitors
id: CHEBI:133022
in subset: 3 STAR

lymphocyte function-associated antigen-1 antagonist
type: Class
subclass of: antagonist
textual definition: Any antagonist of lymphocyte function-associated antigen-1
imported from: chebi.owl
has cross-reference: Wikipedia:Lymphocyte_function-associated_antigen_1
has_obo_namespace: chebi_ontology
has_related_synonym: LFA-1 antagonist
has_related_synonym: LFA-1 antagonists
has_related_synonym: lymphocyte function-associated antigen-1 antagonists
id: CHEBI:133024
in subset: 3 STAR

chemical hybridisation agent
type: Class
subclass of: plant growth regulator
textual definition: A plant growth regulator that produces male sterility in plants by preventing pollen development, pollen shed, or pollen viability. This makes the plant adaptable to hybridization without the need for laborious hand pollination.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: chemical hybridisation agents
has_related_synonym: chemical hybridization agent
has_related_synonym: chemical hybridization agents
id: CHEBI:133106
in subset: 3 STAR

fatty acid oxidation inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: A compound that inhibits the oxidation of any fatty acid.
imported from: chebi.owl
has cross-reference: Wikipedia:Fatty_acid_oxidation_inhibitors
has_obo_namespace: chebi_ontology
has_related_synonym: fatty acid oxidation inhibitors
id: CHEBI:133190
in subset: 3 STAR

EC 2.4.1.17 (glucuronosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of glucuronosyltransferase (EC 2.4.1.17).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 1-naphthol glucuronyltransferase inhibitor
has_related_synonym: 1-naphthol glucuronyltransferase inhibitors
has_related_synonym: 1-naphthol-UDP-glucuronosyltransferase inhibitor
has_related_synonym: 1-naphthol-UDP-glucuronosyltransferase inhibitors
has_related_synonym: 17-OH steroid UDPGT inhibitor
has_related_synonym: 17-OH steroid UDPGT inhibitors
has_related_synonym: 17beta-hydroxysteroid UDP-glucuronosyltransferase inhibitor
has_related_synonym: 17beta-hydroxysteroid UDP-glucuronosyltransferase inhibitors
has_related_synonym: 3-OH androgenic UDPGT inhibitor
has_related_synonym: 3-OH androgenic UDPGT inhibitors
has_related_synonym: 3alpha-hydroxysteroid UDP-glucuronosyltransferase inhibitor
has_related_synonym: 3alpha-hydroxysteroid UDP-glucuronosyltransferase inhibitors
has_related_synonym: 4-hydroxybiphenyl UDP-glucuronosyltransferase inhibitor
has_related_synonym: 4-hydroxybiphenyl UDP-glucuronosyltransferase inhibitors
has_related_synonym: EC 2.4.1.17 (glucuronosyltransferase) inhibitors
has_related_synonym: EC 2.4.1.17 inhibitor
has_related_synonym: EC 2.4.1.17 inhibitors
has_related_synonym: UDP glucuronic acid transferase inhibitors
has_related_synonym: UDP glucuronosyltransferase inhibitor
has_related_synonym: UDP glucuronosyltransferase inhibitors
has_related_synonym: UDP glucuronyltransferase inhibitor
has_related_synonym: UDP glucuronyltransferase inhibitors
has_related_synonym: UDP-alpha-D-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific; conformation-inverting) inhibitor
has_related_synonym: UDP-alpha-D-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific; conformation-inverting) inhibitors
has_related_synonym: UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) inhibitor
has_related_synonym: UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) inhibitors
has_related_synonym: UDP-glucuronyltransferase inhibitor
has_related_synonym: UDP-glucuronyltransferase inhibitors
has_related_synonym: UDPGA transferase inhibitor
has_related_synonym: UDPGA transferase inhibitors
has_related_synonym: UDPGA-glucuronyltransferase inhibitor
has_related_synonym: UDPGA-glucuronyltransferase inhibitors
has_related_synonym: UDPGT inhibitor
has_related_synonym: UDPGT inhibitors
has_related_synonym: glucuronosyltransferase inhibitor
has_related_synonym: glucuronosyltransferase inhibitors
has_related_synonym: uridine 5'-diphosphoglucuronyltransferase inhibitor
has_related_synonym: uridine 5'-diphosphoglucuronyltransferase inhibitors
has_related_synonym: uridine diphosphate glucuronyltransferase inhibitor
has_related_synonym: uridine diphosphate glucuronyltransferase inhibitors
has_related_synonym: uridine diphosphoglucuronosyltransferase inhibitor
has_related_synonym: uridine diphosphoglucuronosyltransferase inhibitors
has_related_synonym: uridine diphosphoglucuronyltransferase inhibitor
has_related_synonym: uridine diphosphoglucuronyltransferase inhibitors
id: CHEBI:133811
in subset: 3 STAR

neuropeptide Y receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates neuropeptide Y receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Neuropeptide_Y_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: neuropeptide Y receptor antagonists
id: CHEBI:133878
in subset: 3 STAR

salt-inducible kinase 2 inhibitor
type: Class
subclass of: protein kinase inhibitor
textual definition: Any protein kinase inhibitor that interferes with the action of salt-inducible kinase 2.
imported from: chebi.owl
has cross-reference: Wikipedia:SNF1LK2
has_obo_namespace: chebi_ontology
has_related_synonym: SIK2 inhibitor
has_related_synonym: SIK2 inhibitors
has_related_synonym: SNF1LK2 inhibitor
has_related_synonym: SNF1LK2 inhibitors
has_related_synonym: salt-inducible kinase 2 inhibitors
has_related_synonym: serine/threonine-protein kinase SIK2 inhibitor
id: CHEBI:133891
in subset: 3 STAR

EC 2.5.1.46 (deoxyhypusine synthase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of deoxyhypusine synthase (EC 2.5.1.46).
imported from: chebi.owl
has cross-reference: Wikipedia:Deoxyhypusine_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: (4-aminobutyl)lysine synthase inhibitor
has_related_synonym: (4-aminobutyl)lysine synthase inhibitors
has_related_synonym: DHS inhibitor
has_related_synonym: DHS inhibitors
has_related_synonym: EC 2.5.1.46 (deoxyhypusine synthase) inhibitors
has_related_synonym: EC 2.5.1.46 inhibitor
has_related_synonym: EC 2.5.1.46 inhibitors
has_related_synonym: [eIF-5A]-deoxyhypusine synthase inhibitor
has_related_synonym: [eIF-5A]-deoxyhypusine synthase inhibitors
has_related_synonym: [eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitor
has_related_synonym: [eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitors
has_related_synonym: spermidine dehydrogenase inhibitor
has_related_synonym: spermidine dehydrogenase inhibitors
has_related_synonym: spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitor
has_related_synonym: spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitors
id: CHEBI:133895
in subset: 3 STAR

hypoxia-inducible factor pathway activator
type: Class
subclass of: activator
textual definition: An activator that activates the hypoxia inducible factor (HIF) pathway.
imported from: chebi.owl
has cross-reference: Wikipedia:Hypoxia-inducible_factors
has_obo_namespace: chebi_ontology
has_related_synonym: HIF pathway activator
has_related_synonym: HIF pathway activators
has_related_synonym: hypoxia activator
has_related_synonym: hypoxia activators
has_related_synonym: hypoxia-inducible factor pathway activators
id: CHEBI:134083
in subset: 3 STAR

EC 1.15.1.1 (superoxide dismutase) inhibitor
type: Class
subclass of: EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:134084
in subset: 1 STAR

lipopolysaccharide biosynthesis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any compound that inhibits the biosynthesis of any lipopolysaccharide.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: lipopolysaccharide biosynthesis inhibitors
id: CHEBI:134108
in subset: 3 STAR

EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of UDP-3-O-acyl-N-acetylglucosamine deacetylase (EC 3.5.1.108).
imported from: chebi.owl
has cross-reference: Wikipedia:UDP-3-O-N-acetylglucosamine_deacetylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitors
has_related_synonym: EC 3.5.1.108 inhibitor
has_related_synonym: EC 3.5.1.108 inhibitors
has_related_synonym: LpxC deacetylase inhibitor
has_related_synonym: LpxC deacetylase inhibitors
has_related_synonym: LpxC enzyme inhibitor
has_related_synonym: LpxC enzyme inhibitors
has_related_synonym: LpxC inhibitor
has_related_synonym: LpxC inhibitors
has_related_synonym: UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase inhibitor
has_related_synonym: UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase inhibitors
has_related_synonym: UDP-(3-O-acyl)-N-acetylglucosamine deacetylase inhibitor
has_related_synonym: UDP-(3-O-acyl)-N-acetylglucosamine deacetylase inhibitors
has_related_synonym: UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitor
has_related_synonym: UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitors
has_related_synonym: UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitor
has_related_synonym: UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitors
has_related_synonym: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine amidohydrolase inhibitor
has_related_synonym: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine amidohydrolase inhibitors
has_related_synonym: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase inhibitor
has_related_synonym: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase inhibitors
has_related_synonym: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase inhibitor
has_related_synonym: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase inhibitors
has_related_synonym: UDP-3-O-acyl-GlcNAc deacetylase inhibitor
has_related_synonym: UDP-3-O-acyl-GlcNAc deacetylase inhibitors
has_related_synonym: deacetylase LpxC inhibitor
has_related_synonym: deacetylase LpxC inhibitors
id: CHEBI:134109
in subset: 3 STAR

antidote to barbiturate poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralise the deleterious effects of barbiturates.
imported from: chebi.owl
has cross-reference: PMID:15432128
has_obo_namespace: chebi_ontology
has_related_synonym: antidote to barbiturate overdose
id: CHEBI:134173
in subset: 3 STAR

platelet-activating factor receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that acts at the platelet-activating factor receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: PAF antagonist
has_related_synonym: PAF antagonists
has_related_synonym: platelet-activating factor receptor antagonists
id: CHEBI:134182
in subset: 3 STAR

EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor
type: Class
subclass of: EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
textual definition: An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrolipoyl dehydrogenase (EC 1.8.1.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Dihydrolipoamide_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: E3 component of alpha-ketoacid dehydrogenase complexes inhibitor
has_related_synonym: E3 component of alpha-ketoacid dehydrogenase complexes inhibitors
has_related_synonym: EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitors
has_related_synonym: EC 1.8.1.4 inhibitor
has_related_synonym: EC 1.8.1.4 inhibitors
has_related_synonym: L-protein inhibitor
has_related_synonym: L-protein inhibitors
has_related_synonym: LDP-Glc inhibitor
has_related_synonym: LDP-Glc inhibitors
has_related_synonym: LDP-Val inhibitor
has_related_synonym: LDP-Val inhibitors
has_related_synonym: dehydrolipoate dehydrogenase inhibitor
has_related_synonym: dehydrolipoate dehydrogenase inhibitors
has_related_synonym: diaphorase inhibitor
has_related_synonym: diaphorase inhibitors
has_related_synonym: dihydrolipoamide dehydrogenase inhibitor
has_related_synonym: dihydrolipoamide dehydrogenase inhibitors
has_related_synonym: dihydrolipoamide:NAD(+) oxidoreductase inhibitor
has_related_synonym: dihydrolipoamide:NAD(+) oxidoreductase inhibitors
has_related_synonym: dihydrolipoic dehydrogenase inhibitor
has_related_synonym: dihydrolipoic dehydrogenase inhibitors
has_related_synonym: dihydrothioctic dehydrogenase inhibitor
has_related_synonym: dihydrothioctic dehydrogenase inhibitors
has_related_synonym: glycine-cleavage system L-protein inhibitor
has_related_synonym: glycine-cleavage system L-protein inhibitors
has_related_synonym: lipoamide dehydrogenase (NADH) inhibitor
has_related_synonym: lipoamide dehydrogenase (NADH) inhibitors
has_related_synonym: lipoamide oxidoreductase (NADH) inhibitor
has_related_synonym: lipoamide oxidoreductase (NADH) inhibitors
has_related_synonym: lipoamide reductase (NADH) inhibitor
has_related_synonym: lipoamide reductase (NADH) inhibitors
has_related_synonym: lipoamide reductase inhibitor
has_related_synonym: lipoamide reductase inhibitors
has_related_synonym: lipoate dehydrogenase inhibitor
has_related_synonym: lipoate dehydrogenase inhibitors
has_related_synonym: lipoic acid dehydrogenase inhibitor
has_related_synonym: lipoic acid dehydrogenase inhibitors
has_related_synonym: lipoyl dehydrogenase inhibitor
has_related_synonym: lipoyl dehydrogenase inhibitors
has_related_synonym: protein-6-N-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitor
has_related_synonym: protein-6-N-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitors
has_related_synonym: protein-N(6)-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitor
has_related_synonym: protein-N(6)-(dihydrolipoyl)lysine:NAD(+) oxidoreductase inhibitors
id: CHEBI:134545
in subset: 3 STAR

EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.2.* (pentosyltransferase) inhibitor
textual definition: An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of hypoxanthine phosphoribosyltransferase (EC 2.4.2.8).
imported from: chebi.owl
has cross-reference: Wikipedia:Hypoxanthine-guanine_phosphoribosyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: 6-hydroxypurine phosphoribosyltransferase inhibitor
has_related_synonym: 6-mercaptopurine phosphoribosyltransferase inhibitor
has_related_synonym: EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitors
has_related_synonym: EC 2.4.2.8 inhibitor
has_related_synonym: EC 2.4.2.8 inhibitors
has_related_synonym: GMP pyrophosphorylase inhibitor
has_related_synonym: GPRT inhibitor
has_related_synonym: HGPRTase inhibitor
has_related_synonym: HPRT inhibitor
has_related_synonym: IMP pyrophosphorylase inhibitor
has_related_synonym: IMP-GMP pyrophosphorylase inhibitor
has_related_synonym: IMP:diphosphate phospho-D-ribosyltransferase inhibitor
has_related_synonym: guanine phosphoribosyltransferase inhibitor
has_related_synonym: guanine-hypoxanthine phosphoribosyltransferase inhibitor
has_related_synonym: guanosine 5'-phosphate pyrophosphorylase inhibitor
has_related_synonym: guanosine phosphoribosyltransferase inhibitor
has_related_synonym: guanylate pyrophosphorylase inhibitor
has_related_synonym: guanylic pyrophosphorylase inhibitor
has_related_synonym: hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) inhibitor
has_related_synonym: hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) inhibitors
has_related_synonym: hypoxanthine phosphoribosyltransferase inhibitor
has_related_synonym: hypoxanthine phosphoribosyltransferase inhibitors
has_related_synonym: hypoxanthine-guanine phosphoribosyltransferase inhibitor
has_related_synonym: inosinate pyrophosphorylase inhibitor
has_related_synonym: inosine 5'-phosphate pyrophosphorylas inhibitore
has_related_synonym: inosinic acid pyrophosphorylase inhibitor
has_related_synonym: inosinic pyrophosphorylase inhibitor
has_related_synonym: purine-6-thiol phosphoribosyltransferase inhibitor
has_related_synonym: transphosphoribosidase inhibitor
id: CHEBI:136537
in subset: 3 STAR

EC 1.11.1.7 (peroxidase) inhibitor
type: Class
subclass of: EC 1.11.1.* (peroxidases) inhibitor
textual definition: An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of peroxidase (EC 1.11.1.7).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Arthromyces ramosus peroxidase inhibitor
has_related_synonym: Arthromyces ramosus peroxidase inhibitors
has_related_synonym: Coprinus cinereus peroxidase inhibitor
has_related_synonym: Coprinus cinereus peroxidase inhibitors
has_related_synonym: EC 1.11.1.7 (peroxidase) inhibitors
has_related_synonym: EC 1.11.1.7 inhibitor
has_related_synonym: EC 1.11.1.7 inhibitors
has_related_synonym: HRP inhibitor
has_related_synonym: HRP inhibitors
has_related_synonym: Japanese radish peroxidase inhibitor
has_related_synonym: Japanese radish peroxidase inhibitors
has_related_synonym: extensin peroxidase inhibitor
has_related_synonym: extensin peroxidase inhibitors
has_related_synonym: guaiacol peroxidase inhibitor
has_related_synonym: guaiacol peroxidase inhibitors
has_related_synonym: heme peroxidase inhibitor
has_related_synonym: heme peroxidase inhibitors
has_related_synonym: horseradish peroxidase (HRP) inhibitor
has_related_synonym: horseradish peroxidase (HRP) inhibitors
has_related_synonym: horseradish peroxidase inhibitor
has_related_synonym: horseradish peroxidase inhibitors
has_related_synonym: lactoperoxidase inhibitor
has_related_synonym: lactoperoxidase inhibitors
has_related_synonym: oxyperoxidase inhibitor
has_related_synonym: oxyperoxidase inhibitors
has_related_synonym: peroxidase (EC 1.11.1.7) inhibitor
has_related_synonym: peroxidase (EC 1.11.1.7) inhibitors
has_related_synonym: peroxidase inhibitor
has_related_synonym: peroxidase inhibitors
has_related_synonym: phenolic donor:hydrogen-peroxide oxidoreductase inhibitor
has_related_synonym: phenolic donor:hydrogen-peroxide oxidoreductase inhibitors
has_related_synonym: plant peroxidase inhibitor
has_related_synonym: plant peroxidase inhibitors
has_related_synonym: protoheme peroxidase inhibitor
has_related_synonym: protoheme peroxidase inhibitors
has_related_synonym: pyrocatechol peroxidase inhibitor
has_related_synonym: pyrocatechol peroxidase inhibitors
has_related_synonym: scopoletin peroxidase inhibitor
has_related_synonym: scopoletin peroxidase inhibitors
has_related_synonym: soybean peroxidase (SBP) inhibitor
has_related_synonym: soybean peroxidase (SBP) inhibitors
id: CHEBI:136558
in subset: 3 STAR

LRH-1 antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that acts at the liver receptor homologue-1.
imported from: chebi.owl
has cross-reference: Wikipedia:Liver_receptor_homolog-1
has_obo_namespace: chebi_ontology
has_related_synonym: LRH-1 antagonists
has_related_synonym: NR5A2 antagonist
has_related_synonym: NR5A2 antagonists
has_related_synonym: liver receptor homolog-1 antagonist
has_related_synonym: liver receptor homolog-1 antagonists
has_related_synonym: liver receptor homologue-1 antagonist
has_related_synonym: liver receptor homologue-1 antagonists
has_related_synonym: nuclear receptor subfamily 5 group A member 2 antagonist
has_related_synonym: nuclear receptor subfamily 5 group A member 2 antagonists
id: CHEBI:136580
in subset: 3 STAR

propesticide
type: Class
subclass of: pro-agent
subclass of: pesticide
textual definition: A prodrug that, on administration, undergoes chemical conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the pharmacologically active pesticide for which it is a propesticide.
imported from: chebi.owl
has cross-reference: AGR:IND84086009
has cross-reference: PMID:26449612
has_obo_namespace: chebi_ontology
has_related_synonym: pro-pesticide
has_related_synonym: pro-pesticides
has_related_synonym: propesticides
id: CHEBI:136643
in subset: 3 STAR

proinsecticide
type: Class
subclass of: propesticide
subclass of: insecticide
textual definition: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active insecticide for which it is a proinsecticide.
imported from: chebi.owl
has cross-reference: AGR:IND20386178
has cross-reference: AGR:IND84086011
has cross-reference: AGR:IND89021681
has cross-reference: AGR:IND92003154
has cross-reference: PMID:16172027
has cross-reference: PMID:26449612
has cross-reference: PMID:27414472
has cross-reference: PMID:27976502
has_obo_namespace: chebi_ontology
has_related_synonym: pro-insecticide
has_related_synonym: pro-insecticides
has_related_synonym: proinsecticides
id: CHEBI:136644
in subset: 3 STAR

profungicide
type: Class
subclass of: propesticide
subclass of: fungicide
textual definition: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active fungicide for which it is a profungicide.
imported from: chebi.owl
has cross-reference: PMID:11929539
has cross-reference: PMID:25746994
has cross-reference: PMID:26449612
has_obo_namespace: chebi_ontology
has_related_synonym: pro-fungicide
has_related_synonym: pro-fungicides
has_related_synonym: profungicides
id: CHEBI:136645
in subset: 3 STAR

proherbicide
type: Class
subclass of: propesticide
subclass of: herbicide
textual definition: A compound that, on administration, must undergo chemical conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the pharmacologically active herbicide for which it is a proherbicide.
imported from: chebi.owl
has cross-reference: AGR:IND43789627
has cross-reference: PMID:12232216
has cross-reference: PMID:26449612
has cross-reference: PMID:27280658
has_obo_namespace: chebi_ontology
has_related_synonym: pro-herbicide
has_related_synonym: pro-herbicides
has_related_synonym: proherbicides
id: CHEBI:136646
in subset: 3 STAR

proacaricide
type: Class
subclass of: propesticide
subclass of: acaricide
textual definition: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active insecticide for which it is a proacaricide.
imported from: chebi.owl
has cross-reference: PMID:17046600
has cross-reference: PMID:19330529
has cross-reference: PMID:26449612
has_obo_namespace: chebi_ontology
has_related_synonym: pro-acaricide
has_related_synonym: pro-acaricides
has_related_synonym: proacaricides
id: CHEBI:136647
in subset: 3 STAR

prosafener
type: Class
subclass of: herbicide safener
subclass of: propesticide
textual definition: A compound that, on administration, must undergo chemical conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the pharmacologically active herbicide savener for which it is a prosafener.
imported from: chebi.owl
has cross-reference: PMID:26449612
has_obo_namespace: chebi_ontology
has_related_synonym: pro-safener
has_related_synonym: pro-safeners
has_related_synonym: prosafeners
id: CHEBI:136648
in subset: 3 STAR

S100 calcium-binding protein B inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of S100 calcium-binding protein B.
imported from: chebi.owl
has cross-reference: Wikipedia:S100B
has_obo_namespace: chebi_ontology
has_related_synonym: S100 calcium-binding protein B inhibitors
has_related_synonym: S100B inhibitor
has_related_synonym: S100B inhibitors
id: CHEBI:136651
in subset: 3 STAR

pro-agent
type: Class
subclass of: application
textual definition: A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent.
imported from: chebi.owl
has cross-reference: PMID:26449612
has_obo_namespace: chebi_ontology
has_related_synonym: pro-agents
has_related_synonym: proagent
has_related_synonym: proagents
id: CHEBI:136859
in subset: 3 STAR

antidote to sarin poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralise the nerve agent sarin.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:136860
in subset: 3 STAR

EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitor
type: Class
subclass of: EC 4.4.1.* (C-S lyase) inhibitor
textual definition: An EC 4.4.1.* (C-S lyase) inhibitor that interferes with the action of 1-aminocyclopropane-1-carboxylate synthase (EC 4.4.1.14).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 1-aminocyclopropane-1-carboxylate synthase inhibitor
has_related_synonym: 1-aminocyclopropane-1-carboxylate synthase inhibitors
has_related_synonym: 1-aminocyclopropane-1-carboxylate synthetase inhibitor
has_related_synonym: 1-aminocyclopropane-1-carboxylate synthetase inhibitors
has_related_synonym: 1-aminocyclopropane-1-carboxylic acid synthase inhibitor
has_related_synonym: 1-aminocyclopropane-1-carboxylic acid synthase inhibitors
has_related_synonym: 1-aminocyclopropanecarboxylate synthase inhibitor
has_related_synonym: 1-aminocyclopropanecarboxylate synthase inhibitors
has_related_synonym: ACC synthase inhibitor
has_related_synonym: ACC synthase inhibitors
has_related_synonym: EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitors
has_related_synonym: EC 4.4.1.14 inhibitor
has_related_synonym: EC 4.4.1.14 inhibitors
has_related_synonym: S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming) inhibitor
has_related_synonym: S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming) inhibitors
has_related_synonym: S-adenosyl-L-methionine methylthioadenosine-lyase inhibitor
has_related_synonym: S-adenosyl-L-methionine methylthioadenosine-lyase inhibitors
has_related_synonym: aminocyclopropanecarboxylate synthase inhibitor
has_related_synonym: aminocyclopropanecarboxylate synthase inhibitors
has_related_synonym: aminocyclopropanecarboxylic acid synthase inhibitor
has_related_synonym: aminocyclopropanecarboxylic acid synthase inhibitors
id: CHEBI:136984
in subset: 3 STAR

eukaryotic initiation factor 4F inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any compound that inihibits the mammalian protein, eukaryotic initiation factor 4F.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: eIF4F inhibitor
has_related_synonym: eIF4F inhibitors
has_related_synonym: eukaryotic initiation factor 4F inhibitors
id: CHEBI:137079
in subset: 3 STAR

bromodomain-containing protein 4 inhibitor
type: Class
subclass of: BET bromodomain inhibitor
textual definition: Any inhibitor of bromodomain-containing protein 4 (BRD4).
imported from: chebi.owl
has cross-reference: Wikipedia:BRD4
has_obo_namespace: chebi_ontology
has_related_synonym: BRD4 inhibitor
has_related_synonym: BRD4 inhibitors
has_related_synonym: bromodomain-containing protein 4 inhibitors
id: CHEBI:137114
in subset: 3 STAR

EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30).
imported from: chebi.owl
has cross-reference: Wikipedia:Receptor_protein_serine/threonine_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:[receptor-protein] phosphotransferase inhibitor
has_related_synonym: ATP:[receptor-protein] phosphotransferase inhibitors
has_related_synonym: EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitors
has_related_synonym: EC 2.7.11.30 inhibitor
has_related_synonym: EC 2.7.11.30 inhibitors
has_related_synonym: STK13 inhibitor
has_related_synonym: STK13 inhibitors
has_related_synonym: TGF-beta kinase inhibitor
has_related_synonym: TGF-beta kinase inhibitors
has_related_synonym: activin receptor kinase inhibitor
has_related_synonym: activin receptor kinase inhibitors
has_related_synonym: inhibitor of receptor protein serine/threonine kinase
has_related_synonym: receptor protein serine/threonine kinase (EC 2.7.11.30) inhibitor
has_related_synonym: receptor protein serine/threonine kinase (EC 2.7.11.30) inhibitors
has_related_synonym: receptor protein serine/threonine kinase inhibitor
has_related_synonym: receptor protein serine/threonine kinase inhibitors
has_related_synonym: receptor serine/threonine protein kinase inhibitor
has_related_synonym: receptor serine/threonine protein kinase inhibitors
has_related_synonym: receptor type I serine/threonine protein kinase inhibitor
has_related_synonym: receptor type I serine/threonine protein kinase inhibitors
has_related_synonym: receptor type II serine/threonine protein kinase inhibitor
has_related_synonym: receptor type II serine/threonine protein kinase inhibitors
id: CHEBI:137123
in subset: 3 STAR

capsaicin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates capsaicin receptors
imported from: chebi.owl
has cross-reference: Wikipedia:TRPV1
has_obo_namespace: chebi_ontology
has_related_synonym: TRPV1 agonist
has_related_synonym: TRPV1 agonists
has_related_synonym: capsaicin agonist
has_related_synonym: capsaicin agonists
has_related_synonym: capsaicin receptor agonists
has_related_synonym: transient receptor potential cation channel subfamily V member 1 agonist
has_related_synonym: transient receptor potential cation channel subfamily V member 1 agonists
has_related_synonym: vanilloid receptor 1 agonist
has_related_synonym: vanilloid receptor 1 agonists
id: CHEBI:137401
in subset: 3 STAR

antihypotensive agent
type: Class
subclass of: cardiovascular drug
textual definition: A cardiovascular drug that tends to raise reduced blood pressure.
imported from: chebi.owl
has cross-reference: Wikipedia:Antihypotensive_agent
has_obo_namespace: chebi_ontology
has_related_synonym: antihypotensive agents
has_related_synonym: pressor
has_related_synonym: pressors
has_related_synonym: vasopressor agent
has_related_synonym: vasopressor agents
id: CHEBI:137431
in subset: 3 STAR

TRPA1 channel agonist
type: Class
subclass of: agonist
textual definition: An agonist at the transient receptor potential cation channel A1 (TRPA1).
imported from: chebi.owl
has cross-reference: Wikipedia:TRPA1
has_obo_namespace: chebi_ontology
has_related_synonym: TRPA1 channel agonists
has_related_synonym: transient receptor potential ankyrin 1 agonist
has_related_synonym: transient receptor potential ankyrin 1 agonists
has_related_synonym: transient receptor potential cation channel A1 agonist
has_related_synonym: transient receptor potential cation channel A1 agonists
id: CHEBI:137514
in subset: 3 STAR

EC 2.5.1.48 (cystathionine gamma-synthase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of cystathionine gamma-synthase (EC 2.5.1.48).
imported from: chebi.owl
has cross-reference: Wikipedia:Cystathionine_gamma-synthase
has_obo_namespace: chebi_ontology
has_related_synonym: 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitor
has_related_synonym: 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitors
has_related_synonym: EC 2.5.1.48 (cystathionine gamma-synthase) inhibitors
has_related_synonym: EC 2.5.1.48 inhibitor
has_related_synonym: EC 2.5.1.48 inhibitors
has_related_synonym: O(4)-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitor
has_related_synonym: O(4)-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitors
has_related_synonym: O-succinyl-L-homoserine succinate-lyase (adding cysteine) inhibitor
has_related_synonym: O-succinyl-L-homoserine succinate-lyase (adding cysteine) inhibitors
has_related_synonym: O-succinylhomoserine (thiol)-lyase inhibitor
has_related_synonym: O-succinylhomoserine (thiol)-lyase inhibitors
has_related_synonym: O-succinylhomoserine synthase inhibitor
has_related_synonym: O-succinylhomoserine synthase inhibitors
has_related_synonym: O-succinylhomoserine synthetase inhibitor
has_related_synonym: O-succinylhomoserine synthetase inhibitors
has_related_synonym: cystathionine gamma-synthase inhibitor
has_related_synonym: cystathionine gamma-synthase inhibitors
has_related_synonym: cystathionine synthase inhibitor
has_related_synonym: cystathionine synthase inhibitors
has_related_synonym: cystathionine synthetase inhibitor
has_related_synonym: cystathionine synthetase inhibitors
has_related_synonym: homoserine O-transsuccinylase inhibitor
has_related_synonym: homoserine O-transsuccinylase inhibitors
has_related_synonym: homoserine transsuccinylase inhibitor
has_related_synonym: homoserine transsuccinylase inhibitors
id: CHEBI:137566
in subset: 3 STAR

EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of 11beta-hydroxysteroid dehydrogenase (EC 1.1.1.146).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 11beta-hydroxy steroid dehydrogenase inhibitor
has_related_synonym: 11beta-hydroxy steroid dehydrogenase inhibitors
has_related_synonym: 11beta-hydroxysteroid dehydrogenase inhibitor
has_related_synonym: 11beta-hydroxysteroid dehydrogenase inhibitors
has_related_synonym: 11beta-hydroxysteroid dehydrogenase type 1 inhibitor
has_related_synonym: 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
has_related_synonym: 11beta-hydroxysteroid:NADP(+) 11-oxidoreductase inhibitor
has_related_synonym: 11beta-hydroxysteroid:NADP(+) 11-oxidoreductase inhibitors
has_related_synonym: EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.146 inhibitor
has_related_synonym: EC 1.1.1.146 inhibitors
has_related_synonym: beta-hydroxysteroid dehydrogenase inhibitor
has_related_synonym: beta-hydroxysteroid dehydrogenase inhibitors
has_related_synonym: corticosteroid 11-reductase inhibitor
has_related_synonym: corticosteroid 11-reductase inhibitors
has_related_synonym: corticosteroid 11beta-dehydrogenase inhibitor
has_related_synonym: corticosteroid 11beta-dehydrogenase inhibitors
has_related_synonym: dehydrogenase, 11beta-hydroxy steroid inhibitor
has_related_synonym: dehydrogenase, 11beta-hydroxy steroid inhibitors
id: CHEBI:137626
in subset: 3 STAR

Papio hamadryas metabolite
type: Class
subclass of: mammalian metabolite
textual definition: Any mammalian metabolite produced during a metabolic reaction in Papio hamadryas.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: P. hamadryas metabolite
has_related_synonym: P. hamadryas metabolites
has_related_synonym: Papio hamadryas metabolites
id: CHEBI:137684
in subset: 3 STAR

anxiogenic
type: Class
subclass of: psychotropic drug
textual definition: Any psychotropic drug that induces anxiety or panic.
imported from: chebi.owl
has cross-reference: Wikipedia:Anxiogenic
has_obo_namespace: chebi_ontology
has_related_synonym: anxiogenics
has_related_synonym: panicogenic
has_related_synonym: panicogenics
id: CHEBI:137736
in subset: 3 STAR

EC 3.4.22.56 (caspase-3) inhibitor
type: Class
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of caspase-3 (EC 3.4.22.56).
imported from: chebi.owl
has cross-reference: Wikipedia:Caspase_3
has_obo_namespace: chebi_ontology
has_related_synonym: CASP-3 inhibitor
has_related_synonym: CASP-3 inhibitors
has_related_synonym: CPP32 inhibitor
has_related_synonym: CPP32 inhibitors
has_related_synonym: EC 3.4.22.56 (caspase-3) inhibitors
has_related_synonym: EC 3.4.22.56 inhibitor
has_related_synonym: EC 3.4.22.56 inhibitors
has_related_synonym: apopain inhibitor
has_related_synonym: apopain inhibitors
has_related_synonym: caspase-3 (EC 3.4.22.56) inhibitor
has_related_synonym: caspase-3 (EC 3.4.22.56) inhibitors
has_related_synonym: caspase-3 inhibitor
has_related_synonym: caspase-3 inhibitors
has_related_synonym: yama protein inhibitor
has_related_synonym: yama protein inhibitors
id: CHEBI:138014
in subset: 3 STAR

endocrine disruptor
type: Class
subclass of: hormone receptor modulator
textual definition: Any compound that can disrupt the functions of the endocrine (hormone) system
imported from: chebi.owl
has cross-reference: PMID:27929035
has cross-reference: PMID:28356401
has cross-reference: PMID:28526231
has cross-reference: Wikipedia:Endocrine_disruptor
has_obo_namespace: chebi_ontology
has_related_synonym: endocrine disrupting chemical
has_related_synonym: endocrine disrupting chemicals
has_related_synonym: endocrine disrupting compound
has_related_synonym: endocrine disrupting compounds
has_related_synonym: endocrine disruptors
has_related_synonym: endocrine-disrupting chemical
has_related_synonym: endocrine-disrupting chemicals
has_related_synonym: hormonally active agent
has_related_synonym: hormonally active agents
id: CHEBI:138015
in subset: 3 STAR

ATPase motor cytoplasmic dynein inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of ATPase motor cytoplasmic dynein.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ATPase motor cytoplasmic dynein inhibitors
id: CHEBI:138090
in subset: 3 STAR

inorganic acid
type: Class
subclass of: Bronsted acid
textual definition: A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.
imported from: chebi.owl
has cross-reference: Wikipedia:Mineral_acid
has_obo_namespace: chebi_ontology
has_related_synonym: inorganic acids
has_related_synonym: mineral acid
has_related_synonym: mineral acids
id: CHEBI:138103
in subset: 3 STAR

neuropeptide Y2 receptor agonist
type: Class
subclass of: agonist
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:138168
in subset: 1 STAR

carotenoid biosynthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: Any pathway inhibitor that acts on the carotenoid biosynthesis pathway.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carotenogenesis inhibitor
has_related_synonym: carotenogenesis inhibitors
has_related_synonym: carotenoid biosynthesis inhibitors
has_related_synonym: carotenoid-biosynthesis inhibitor
has_related_synonym: carotenoid-biosynthesis inhibitors
id: CHEBI:138208
in subset: 3 STAR

RhoA inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor that interferes with the action of the protein RhoA.
imported from: chebi.owl
has cross-reference: Wikipedia:RHOA
has_obo_namespace: chebi_ontology
has_related_synonym: Ras homolog gene family, member A inhibitor
has_related_synonym: Ras homolog gene family, member A inhibitors
has_related_synonym: RhoA GTPase inhibitor
has_related_synonym: RhoA GTPase inhibitors
has_related_synonym: RhoA inhibitors
id: CHEBI:138380
in subset: 3 STAR

RhoC inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor that interferes with the action of the protein RhoC.
imported from: chebi.owl
has cross-reference: Wikipedia:RhoC
has_obo_namespace: chebi_ontology
has_related_synonym: Ras homolog gene family, member C inhibitor
has_related_synonym: Ras homolog gene family, member C inhibitors
has_related_synonym: RhoC GTPase inhibitor
has_related_synonym: RhoC GTPase inhibitors
has_related_synonym: RhoC inhibitors
id: CHEBI:138381
in subset: 3 STAR

EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159).
imported from: chebi.owl
has cross-reference: Wikipedia:7alpha-hydroxysteroid_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: 7alpha-HSDH inhibitor
has_related_synonym: 7alpha-HSDH inhibitors
has_related_synonym: 7alpha-hydroxy steroid dehydrogenase inhibitor
has_related_synonym: 7alpha-hydroxy steroid dehydrogenase inhibitors
has_related_synonym: 7alpha-hydroxysteroid dehydrogenase inhibitor
has_related_synonym: 7alpha-hydroxysteroid dehydrogenase inhibitors
has_related_synonym: 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase inhibitor
has_related_synonym: 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase inhibitors
has_related_synonym: EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.159 inhibitor
has_related_synonym: EC 1.1.1.159 inhibitors
id: CHEBI:138390
in subset: 3 STAR

angiotensin receptor agonist
type: Class
subclass of: hormone agonist
textual definition: A hormone antagonist that acts at angiotensin receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: angiotensin receptor agonists
id: CHEBI:138416
in subset: 3 STAR

autophagy inducer
type: Class
subclass of: biochemical role
textual definition: Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: autophagocytosis inducer
has_related_synonym: autophagocytosis inducers
has_related_synonym: autophagy inducers
id: CHEBI:138880
in subset: 3 STAR

prostaglandin receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and blocks the activity of prostaglandin receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Prostaglandin_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: prostaglandin receptor antagonists
has_related_synonym: prostanoid receptor antagonist
has_related_synonym: prostanoid receptor antagonists
id: CHEBI:138887
in subset: 3 STAR

EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor
type: Class
subclass of: EC 6.3.* (C-N bond-forming ligase) inhibitor
textual definition: An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any carbon-nitrogen ligases with glutamine as amido-N-donor (EC 6.3.5.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitors
id: CHEBI:138920
in subset: 3 STAR

EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor
type: Class
subclass of: EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor
textual definition: An EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor that interferes with the action of carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CAD inhibitor
has_related_synonym: CAD inhibitors
has_related_synonym: CPS inhibitor
has_related_synonym: CPS inhibitors
has_related_synonym: EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitors
has_related_synonym: EC 6.3.5.5 inhibitor
has_related_synonym: EC 6.3.5.5 inhibitors
has_related_synonym: GD-CPSase inhibitor
has_related_synonym: GD-CPSase inhibitors
has_related_synonym: HCO3(-):L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitor
has_related_synonym: HCO3(-):L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitors
has_related_synonym: carA inhibitor
has_related_synonym: carA inhibitors
has_related_synonym: carB inhibitor
has_related_synonym: carB inhibitors
has_related_synonym: carbamoyl phosphate synthetase inhibitor
has_related_synonym: carbamoyl phosphate synthetase inhibitors
has_related_synonym: carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) inhibitor
has_related_synonym: carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) inhibitors
has_related_synonym: carbamoyl-phosphate synthetase (glutamine-hydrolysing) inhibitor
has_related_synonym: carbamoyl-phosphate synthetase (glutamine-hydrolysing) inhibitors
has_related_synonym: carbamoylphosphate synthetase II inhibitor
has_related_synonym: carbamoylphosphate synthetase II inhibitors
has_related_synonym: carbamyl phosphate synthetase (glutamine) inhibitor
has_related_synonym: carbamyl phosphate synthetase (glutamine) inhibitors
has_related_synonym: carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitor
has_related_synonym: carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitors
has_related_synonym: glutamine-dependent carbamoyl-phosphate synthase inhibitor
has_related_synonym: glutamine-dependent carbamoyl-phosphate synthase inhibitors
has_related_synonym: glutamine-dependent carbamyl phosphate synthetase inhibitor
has_related_synonym: glutamine-dependent carbamyl phosphate synthetase inhibitors
has_related_synonym: hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitor
has_related_synonym: hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) inhibitors
id: CHEBI:138921
in subset: 3 STAR

EC 6.3.4.* (other carbon--nitrogen ligases) inhibitor
type: Class
subclass of: EC 6.3.* (C-N bond-forming ligase) inhibitor
textual definition: Any EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of 'other carbon--nitrogen ligases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.4.* (other carbon--nitrogen ligases) inhibitors
has_related_synonym: EC 6.3.4.* inhibitor
has_related_synonym: EC 6.3.4.* inhibitors
id: CHEBI:138924
in subset: 3 STAR

EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor
type: Class
subclass of: EC 6.3.4.* (other carbon--nitrogen ligases) inhibitor
textual definition: Any EC 6.3.4.* (other carbon--nitrogen ligases) inhibitor that interferes with the action of CTP synthase (glutamine hydrolyzing) (EC 6.3.4.2).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CTP synthase (glutamine hydrolyzing) (EC6.3.4.2) inhibitor
has_related_synonym: CTP synthase (glutamine hydrolyzing) (EC6.3.4.2) inhibitors
has_related_synonym: CTP synthase (glutamine hydrolyzing) inhibitor
has_related_synonym: CTP synthase (glutamine hydrolyzing) inhibitors
has_related_synonym: CTP synthetase inhibitor
has_related_synonym: CTP synthetase inhibitors
has_related_synonym: CTPS inhibitor
has_related_synonym: CTPS inhibitors
has_related_synonym: EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitors
has_related_synonym: EC 6.3.4.2 inhibitor
has_related_synonym: EC 6.3.4.2 inhibitors
has_related_synonym: UTP--ammonia ligase inhibitor
has_related_synonym: UTP-ammonia ligase inhibitors
has_related_synonym: UTP:L-glutamine amido-ligase (ADP-forming) inhibitor
has_related_synonym: UTP:L-glutamine amido-ligase (ADP-forming) inhibitors
has_related_synonym: cytidine triphosphate synthetase inhibitor
has_related_synonym: cytidine triphosphate synthetase inhibitors
has_related_synonym: pyrG inhibitor
has_related_synonym: pyrG inhibitors
has_related_synonym: uridine triphosphate aminase inhibitor
has_related_synonym: uridine triphosphate aminase inhibitors
id: CHEBI:138925
in subset: 3 STAR

EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor
type: Class
subclass of: EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor
textual definition: Any EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor that interferes with the action of phosphoribosylformylglycinamidine synthase (EC 6.3.5.3).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitor
has_related_synonym: 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitors
has_related_synonym: 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming) inhibitor
has_related_synonym: 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming) inhibitors
has_related_synonym: EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitors
has_related_synonym: EC 6.3.5.3 inhibitor
has_related_synonym: EC 6.3.5.3 inhibitors
has_related_synonym: FGAM synthase inhibitor
has_related_synonym: FGAM synthase inhibitors
has_related_synonym: FGAM synthetase inhibitor
has_related_synonym: FGAM synthetase inhibitors
has_related_synonym: FGAR amidotransferase inhibitor
has_related_synonym: FGAR amidotransferase inhibitors
has_related_synonym: FGARAT inhibitor
has_related_synonym: FGARAT inhibitors
has_related_synonym: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitor
has_related_synonym: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) inhibitors
has_related_synonym: formylglycinamide ribonucloetide amidotransferase inhibitor
has_related_synonym: formylglycinamide ribonucloetide amidotransferase inhibitors
has_related_synonym: formylglycinamide ribotide amidotransferase inhibitor
has_related_synonym: formylglycinamide ribotide amidotransferase inhibitors
has_related_synonym: phosphoribosylformylglycinamidine synthase inhibitor
has_related_synonym: phosphoribosylformylglycinamidine synthase inhibitors
has_related_synonym: phosphoribosylformylglycinamidine synthetase inhibitor
has_related_synonym: phosphoribosylformylglycinamidine synthetase inhibitors
has_related_synonym: phosphoribosylformylglycineamidine synthetase inhibitor
has_related_synonym: phosphoribosylformylglycineamidine synthetase inhibitors
id: CHEBI:138927
in subset: 3 STAR

EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor
type: Class
subclass of: EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor
textual definition: An EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor that interferes with the action of GMP synthase (glutamine-hydrolysing) (EC 6.3.5.2).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitors
has_related_synonym: EC 6.3.5.2 inhibitor
has_related_synonym: EC 6.3.5.2 inhibitors
has_related_synonym: GMP synthase (glutamine-hydrolysing) inhibitor
has_related_synonym: GMP synthase (glutamine-hydrolysing) inhibitors
has_related_synonym: GMP synthetase (glutamine-hydrolysing) inhibitor
has_related_synonym: GMP synthetase (glutamine-hydrolysing) inhibitors
has_related_synonym: guanosine 5'-monophosphate synthetase inhibitor
has_related_synonym: guanosine 5'-monophosphate synthetase inhibitors
has_related_synonym: guanosine monophosphate synthetase (glutamine-hydrolyzing) inhibitor
has_related_synonym: guanosine monophosphate synthetase (glutamine-hydrolyzing) inhibitors
has_related_synonym: guanylate synthetase (glutamine-hydrolyzing) inhibitor
has_related_synonym: guanylate synthetase (glutamine-hydrolyzing) inhibitors
has_related_synonym: xanthosine 5'-phosphate amidotransferase inhibitor
has_related_synonym: xanthosine 5'-phosphate amidotransferase inhibitors
has_related_synonym: xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) inhibitor
has_related_synonym: xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) inhibitors
id: CHEBI:138928
in subset: 3 STAR

glutamine antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that acts on glutamine receptors.
imported from: chebi.owl
has cross-reference: PMID:4400179
has_obo_namespace: chebi_ontology
has_related_synonym: glutamine antagonists
id: CHEBI:138931
in subset: 3 STAR

EC 4.1.1.39 (ribulose-bisphosphate carboxylase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of ribulose-bisphosphate carboxylase (EC 4.1.1.39).
imported from: chebi.owl
has cross-reference: Wikipedia:RuBisCO
has_obo_namespace: chebi_ontology
has_related_synonym: 3-phospho-D-glycerate carboxy-lyase (dimerizing) inhibitor
has_related_synonym: 3-phospho-D-glycerate carboxy-lyase (dimerizing) inhibitors
has_related_synonym: 3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming) inhibitor
has_related_synonym: 3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming) inhibitors
has_related_synonym: D-ribulose 1,5-bisphosphate carboxylase inhibitor
has_related_synonym: D-ribulose 1,5-bisphosphate carboxylase inhibitors
has_related_synonym: D-ribulose 1,5-diphosphate carboxylase inhibitor
has_related_synonym: D-ribulose 1,5-diphosphate carboxylase inhibitors
has_related_synonym: EC 4.1.1.39 (ribulose-bisphosphate carboxylase) inhibitors
has_related_synonym: EC 4.1.1.39 inhibitor
has_related_synonym: EC 4.1.1.39 inhibitors
has_related_synonym: RuBP carboxylase inhibitor
has_related_synonym: RuBP carboxylase inhibitors
has_related_synonym: RuBisCO inhibitor
has_related_synonym: RuBisCO inhibitors
has_related_synonym: carboxydismutase inhibitor
has_related_synonym: carboxydismutase inhibitors
has_related_synonym: diphosphoribulose carboxylase inhibitor
has_related_synonym: diphosphoribulose carboxylase inhibitors
has_related_synonym: ribulose 1,5-bisphosphate carboxylase inhibitor
has_related_synonym: ribulose 1,5-bisphosphate carboxylase inhibitors
has_related_synonym: ribulose 1,5-bisphosphate carboxylase/oxygenase inhibitor
has_related_synonym: ribulose 1,5-bisphosphate carboxylase/oxygenase inhibitors
has_related_synonym: ribulose 1,5-diphosphate carboxylase inhibitor
has_related_synonym: ribulose 1,5-diphosphate carboxylase inhibitors
has_related_synonym: ribulose 1,5-diphosphate carboxylase/oxygenase inhibitor
has_related_synonym: ribulose 1,5-diphosphate carboxylase/oxygenase inhibitors
has_related_synonym: ribulose bisphosphate carboxylase/oxygenase inhibitor
has_related_synonym: ribulose bisphosphate carboxylase/oxygenase inhibitors
has_related_synonym: ribulose diphosphate carboxylase inhibitor
has_related_synonym: ribulose diphosphate carboxylase inhibitors
has_related_synonym: ribulose diphosphate carboxylase/oxygenase inhibitor
has_related_synonym: ribulose diphosphate carboxylase/oxygenase inhibitors
has_related_synonym: ribulose-bisphosphate carboxylase inhibitor
has_related_synonym: ribulose-bisphosphate carboxylase inhibitors
has_related_synonym: rubisco inhibitor
has_related_synonym: rubisco inhibitors
id: CHEBI:138938
in subset: 3 STAR

EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.2.* (pentosyltransferase) inhibitor
textual definition: Any EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of amidophosphoribosyltransferase (EC 2.4.2.14).
imported from: chebi.owl
has cross-reference: Wikipedia:Amidophosphoribosyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: 5'-phosphoribosylpyrophosphate amidotransferase inhibitor
has_related_synonym: 5'-phosphoribosylpyrophosphate amidotransferase inhibitors
has_related_synonym: 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitor
has_related_synonym: 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitors
has_related_synonym: 5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitor
has_related_synonym: 5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitors
has_related_synonym: 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitor
has_related_synonym: 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) inhibitors
has_related_synonym: 5-phosphororibosyl-1-pyrophosphate amidotransferase inhibitor
has_related_synonym: 5-phosphororibosyl-1-pyrophosphate amidotransferase inhibitors
has_related_synonym: EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitors
has_related_synonym: EC 2.4.2.14 inhibitor
has_related_synonym: EC 2.4.2.14 inhibitors
has_related_synonym: alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitor
has_related_synonym: alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase inhibitors
has_related_synonym: amidophosphoribosyltransferase (EC 2.4.2.14) inhibitor
has_related_synonym: amidophosphoribosyltransferase (EC 2.4.2.14) inhibitors
has_related_synonym: amidophosphoribosyltransferase inhibitor
has_related_synonym: amidophosphoribosyltransferase inhibitors
has_related_synonym: glutamine 5-phosphoribosylpyrophosphate amidotransferase inhibitor
has_related_synonym: glutamine 5-phosphoribosylpyrophosphate amidotransferase inhibitors
has_related_synonym: glutamine phosphoribosyldiphosphate amidotransferase inhibitor
has_related_synonym: glutamine phosphoribosyldiphosphate amidotransferase inhibitors
has_related_synonym: glutamine phosphoribosylpyrophosphate amidotransferase inhibitor
has_related_synonym: glutamine phosphoribosylpyrophosphate amidotransferase inhibitors
has_related_synonym: glutamine ribosylpyrophosphate 5-phosphate amidotransferase inhibitor
has_related_synonym: glutamine ribosylpyrophosphate 5-phosphate amidotransferase inhibitors
has_related_synonym: phosphoribose pyrophosphate amidotransferase inhibitor
has_related_synonym: phosphoribose pyrophosphate amidotransferase inhibitors
has_related_synonym: phosphoribosyl pyrophosphate amidotransferase inhibitor
has_related_synonym: phosphoribosyl pyrophosphate amidotransferase inhibitors
has_related_synonym: phosphoribosyldiphosphate 5-amidotransferase inhibitor
has_related_synonym: phosphoribosyldiphosphate 5-amidotransferase inhibitors
has_related_synonym: phosphoribosylpyrophosphate glutamyl amidotransferase inhibitor
has_related_synonym: phosphoribosylpyrophosphate glutamyl amidotransferase inhibitors
id: CHEBI:138952
in subset: 3 STAR

EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor
type: Class
subclass of: EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor
textual definition: Any EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor that interferes with the action of NAD(+) synthase (glutamine-hydrolysing) (EC 6.3.5.1).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: DPN synthetase inhibitor
has_related_synonym: DPN synthetase inhibitors
has_related_synonym: EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitors
has_related_synonym: EC 6.3.5.1 inhibitor
has_related_synonym: EC 6.3.5.1 inhibitors
has_related_synonym: NAD synthetase (glutamine-hydrolysing) inhibitor
has_related_synonym: NAD synthetase (glutamine-hydrolysing) inhibitors
has_related_synonym: NAD(+) synthase (glutamine-hydrolysing) (EC 6.3.5.1) inhibitor
has_related_synonym: NAD(+) synthase (glutamine-hydrolysing) (EC 6.3.5.1) inhibitors
has_related_synonym: NAD(+) synthase (glutamine-hydrolysing) inhibitor
has_related_synonym: NAD(+) synthase (glutamine-hydrolysing) inhibitors
has_related_synonym: NAD(+) synthetase (glutamine-hydrolyzing) inhibitor
has_related_synonym: NAD(+) synthetase (glutamine-hydrolyzing) inhibitors
has_related_synonym: deamido-NAD(+):L-glutamine amido-ligase (AMP-forming) inhibitor
has_related_synonym: deamido-NAD(+):L-glutamine amido-ligase (AMP-forming) inhibitors
has_related_synonym: desamidonicotinamide adenine dinucleotide amidotransferase inhibitor
has_related_synonym: desamidonicotinamide adenine dinucleotide amidotransferase inhibitors
has_related_synonym: nicotinamide adenine dinucleotide synthetase (glutamine) inhibitor
has_related_synonym: nicotinamide adenine dinucleotide synthetase (glutamine) inhibitors
id: CHEBI:138953
in subset: 3 STAR

EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor
type: Class
subclass of: EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor
textual definition: Any EC 6.3.5.* (carbon-nitrogen ligases with glutamine as amido-N-donor) inhibitor that interferes with the action of asparagine synthase (glutamine-hydrolysing), EC 6.3.5.4.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: AS inhibitor
has_related_synonym: AS inhibitors
has_related_synonym: AS-B inhibitor
has_related_synonym: AS-B inhibitors
has_related_synonym: EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitors
has_related_synonym: EC 6.3.5.4 inhibitor
has_related_synonym: EC 6.3.5.4 inhibitors
has_related_synonym: L-aspartate:L-glutamine amido-ligase (AMP-forming) inhibitor
has_related_synonym: L-aspartate:L-glutamine amido-ligase (AMP-forming) inhibitors
has_related_synonym: asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) inhibitor
has_related_synonym: asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) inhibitors
has_related_synonym: asparagine synthase (glutamine-hydrolysing) inhibitor
has_related_synonym: asparagine synthase (glutamine-hydrolysing) inhibitors
has_related_synonym: asparagine synthetase (glutamine-hydrolysing) inhibitor
has_related_synonym: asparagine synthetase (glutamine-hydrolysing) inhibitors
has_related_synonym: asparagine synthetase B inhibitor
has_related_synonym: asparagine synthetase B inhibitors
has_related_synonym: glutamine-dependent asparagine synthetase inhibitor
has_related_synonym: glutamine-dependent asparagine synthetase inhibitors
id: CHEBI:138956
in subset: 3 STAR

quorum sensing inhibitor
type: Class
subclass of: inhibitor
textual definition: Any compound that interferes with bacterial communication (quorum sensing, QS).
imported from: chebi.owl
has cross-reference: PMID:16549654
has cross-reference: PMID:22286987
has cross-reference: PMID:24126008
has cross-reference: PMID:25189863
has cross-reference: PMID:25430794
has cross-reference: PMID:27977197
has cross-reference: PMID:28094526
has cross-reference: PMID:28241461
has cross-reference: PMID:28350449
has cross-reference: PMID:28421612
has cross-reference: PMID:28554093
has cross-reference: PMID:28789564
has cross-reference: PMID:28826080
has cross-reference: PMID:28851971
has cross-reference: PMID:29026943
has cross-reference: PMID:29085409
has_obo_namespace: chebi_ontology
has_related_synonym: QS inhibitor
has_related_synonym: QS inhibitors
has_related_synonym: QSI
has_related_synonym: QSIs
has_related_synonym: quorum sensing inhibitors
id: CHEBI:138977
in subset: 3 STAR

thromboxane A2 agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates thromboxane A2 receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: TXA2/PGH2 agonist
has_related_synonym: TXA2/PGH2 agonists
has_related_synonym: TXA2/PGH2 receptor agonist
has_related_synonym: TXA2/PGH2 receptor agonists
has_related_synonym: thromboxane A2 agonists
has_related_synonym: thromboxane A2 receptor agonist
has_related_synonym: thromboxane A2 receptor agonists
id: CHEBI:139044
in subset: 3 STAR

PERK inhibitor
type: Class
subclass of: EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
textual definition: An EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor that inhibits the expression of protein kinase RNA-like endoplasmic reticulum kinase.
imported from: chebi.owl
has cross-reference: PMID:24107775
has cross-reference: Wikipedia:PERK_inhibitors
has_obo_namespace: chebi_ontology
has_related_synonym: PERK inhibitors
has_related_synonym: PKR-like endoplasmic reticulum kinase inhibitor
has_related_synonym: PKR-like endoplasmic reticulum kinase inhibitors
has_related_synonym: protein kinase R-like endoplasmic reticulum kinase inhibitor
has_related_synonym: protein kinase R-like endoplasmic reticulum kinase inhibitors
id: CHEBI:139055
in subset: 3 STAR

LIM kinase inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An that interferes with the activity of any of the actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: LIM kinase inhibitors
id: CHEBI:139074
in subset: 3 STAR

cis-Golgi ArfGEF GBF inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:139084
in subset: 1 STAR

IP3 receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that activates IP3 receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Inositol_trisphosphate_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: D-myo-inositol 1,4,5-trisphosphate receptor agonist
has_related_synonym: D-myo-inositol 1,4,5-trisphosphate receptor agonists
has_related_synonym: IP3 agonist
has_related_synonym: IP3 agonists
has_related_synonym: IP3 receptor agonists
has_related_synonym: InsP3R agonist
has_related_synonym: InsP3R agonists
has_related_synonym: inositol trisphosphate receptor agonist
has_related_synonym: inositol trisphosphate receptor agonists
id: CHEBI:139109
in subset: 3 STAR

EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of protein O-GlcNAc transferase (EC 2.4.1.255).
imported from: chebi.owl
has cross-reference: PMID:16231908
has cross-reference: PMID:20640461
has cross-reference: PMID:26862193
has cross-reference: PMID:28032764
has cross-reference: Patent:EP2438046
has cross-reference: Patent:WO2010141074
has cross-reference: Wikipedia:Protein_O-GlcNAc_transferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitors
has_related_synonym: EC 2.4.1.255 inhibitor
has_related_synonym: EC 2.4.1.255 inhibitors
has_related_synonym: O-GlcNAc transferase inhibitor
has_related_synonym: O-GlcNAc transferase inhibitors
has_related_synonym: O-linked N-acetylglucosaminyltransferase inhibitor
has_related_synonym: O-linked N-acetylglucosaminyltransferase inhibitors
has_related_synonym: OGTase inhibitor
has_related_synonym: OGTase inhibitors
has_related_synonym: UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase inhibitor
has_related_synonym: UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase inhibitors
has_related_synonym: protein O-GlcNAc transferase (EC 2.4.1.255) inhibitor
has_related_synonym: protein O-GlcNAc transferase (EC 2.4.1.255) inhibitors
has_related_synonym: protein O-GlcNAc transferase inhibitor
has_related_synonym: protein O-GlcNAc transferase inhibitors
has_related_synonym: protein O-linked beta-N-acetylglucosamine transferase inhibitor
has_related_synonym: protein O-linked beta-N-acetylglucosamine transferase inhibitors
has_related_synonym: uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase inhibitor
has_related_synonym: uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase inhibitors
id: CHEBI:139153
in subset: 3 STAR

melanin-concentrating hormone receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that attaches to and blocks melanin-concentrating hormone receptors.
imported from: chebi.owl
has cross-reference: PMID:16889232
has cross-reference: PMID:17448659
has cross-reference: Patent:US2012083489
has cross-reference: Wikipedia:Melanin-concentrating_hormone_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: MCHR agonist
has_related_synonym: MCHR agonists
has_related_synonym: melanin-concentrating hormone receptor antagonists
id: CHEBI:139155
in subset: 3 STAR

nicotinic acid adenine dinucleotide phosphate receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that attaches to and blocks nicotinic acid adenine dinucleotide phosphate receptors.
imported from: chebi.owl
has cross-reference: PMID:21047915
has_obo_namespace: chebi_ontology
has_related_synonym: NAADP antagonist
has_related_synonym: NAADP antagonists
has_related_synonym: NAADP receptor antagonist
has_related_synonym: NAADP receptor antagonists
has_related_synonym: nicotinic acid adenine dinucleotide phosphate receptor antagonists
id: CHEBI:139180
in subset: 3 STAR

peptide probe
type: Class
subclass of: probe
textual definition: A probe that is a small labelled and chemical active peptide which has been structurally modified for reacting with, for example, the beta-lactam moieties of various penicillin-type compounds.
imported from: chebi.owl
has cross-reference: PMID:28987997
has_obo_namespace: chebi_ontology
id: CHEBI:139246
in subset: 3 STAR

EC 1.14.17.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen and with reduced ascorbate as one donor, and incorporation of one atom of oxygen) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:139338
in subset: 1 STAR

EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.17.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen and with reduced ascorbate as one donor, and incorporation of one atom of oxygen) inhibitor
textual definition: An EC 1.14.17.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen and with reduced ascorbate as one donor, and incorporation of one atom of oxygen) inhibitor that interferes with the action of dopamine monooxygenase (EC 1.14.17.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Dopamine_beta-hydroxylase
has_obo_namespace: chebi_ontology
has_related_synonym: (3,4-dihydroxyphenethylamine)beta-mono-oxygenase inhibitor
has_related_synonym: (3,4-dihydroxyphenethylamine)beta-mono-oxygenase inhibitors
has_related_synonym: 3,4-dihydroxyphenethylamine beta-oxidase inhibitor
has_related_synonym: 3,4-dihydroxyphenethylamine beta-oxidase inhibitors
has_related_synonym: 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating) inhibitor
has_related_synonym: 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating) inhibitors
has_related_synonym: 4-(2-aminoethyl)pyrocatechol beta-oxidase inhibitor
has_related_synonym: 4-(2-aminoethyl)pyrocatechol beta-oxidase inhibitors
has_related_synonym: DbetaH inhibitor
has_related_synonym: DbetaH inhibitors
has_related_synonym: EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitors
has_related_synonym: EC 1.14.17.1 inhibitor
has_related_synonym: EC 1.14.17.1 inhibitors
has_related_synonym: MDBH (membrane-associated dopamine beta-monooxygenase) inhibitor
has_related_synonym: MDBH (membrane-associated dopamine beta-monooxygenase) inhibitors
has_related_synonym: SDBH (soluble dopamine beta-monooxygenase) inhibitor
has_related_synonym: SDBH (soluble dopamine beta-monooxygenase) inhibitors
has_related_synonym: dopa beta-hydroxylase inhibitor
has_related_synonym: dopa beta-hydroxylase inhibitors
has_related_synonym: dopamine beta-hydroxylase inhibitor
has_related_synonym: dopamine beta-hydroxylase inhibitors
has_related_synonym: dopamine beta-monooxygenase (EC 1.14.17.1) inhibitor
has_related_synonym: dopamine beta-monooxygenase (EC 1.14.17.1) inhibitors
has_related_synonym: dopamine beta-monooxygenase inhibitor
has_related_synonym: dopamine beta-monooxygenase inhibitors
has_related_synonym: dopamine beta-oxidase inhibitor
has_related_synonym: dopamine beta-oxidase inhibitors
has_related_synonym: dopamine hydroxylase inhibitor
has_related_synonym: dopamine hydroxylase inhibitors
has_related_synonym: dopamine-B-hydroxylase inhibitor
has_related_synonym: dopamine-B-hydroxylase inhibitors
has_related_synonym: oxygenase, dopamine beta-mono-phenylamine beta-hydroxylase inhibitor
has_related_synonym: oxygenase, dopamine beta-mono-phenylamine beta-hydroxylase inhibitors
id: CHEBI:139339
in subset: 3 STAR

TRP channel blocker
type: Class
subclass of: TRP channel modulator
subclass of: membrane transport modulator
textual definition: An agent that inhibits the passage of cations through the transient receptor potential (TRP) channels.
imported from: chebi.owl
has cross-reference: PMID:17445088
has cross-reference: PMID:21198543
has cross-reference: PMID:21607648
has cross-reference: PMID:22308955
has cross-reference: Wikipedia:Transient_receptor_potential_channel
has_obo_namespace: chebi_ontology
has_related_synonym: TRP channel blockers
has_related_synonym: transient receptor potential channel blocker
has_related_synonym: transient receptor potential channel blockers
id: CHEBI:139361
in subset: 3 STAR

sensitiser
type: Class
subclass of: aetiopathogenetic role
textual definition: A chemical compound that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the compound.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sensitisers
has_related_synonym: sensitizer
has_related_synonym: sensitizers
id: CHEBI:139492
in subset: 3 STAR

vitamin D receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates vitamin D receptors
imported from: chebi.owl
has cross-reference: Wikipedia:Calcitriol_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: VDR agonist
has_related_synonym: VDR agonists
has_related_synonym: calcitriol receptor agonist
has_related_synonym: calcitriol receptor agonists
has_related_synonym: vitamin D nuclear receptor agonist
has_related_synonym: vitamin D nuclear receptor agonists
has_related_synonym: vitamin D receptor agonists
id: CHEBI:139503
in subset: 3 STAR

EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor
type: Class
subclass of: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of enoyl-[acyl-carrier-protein] reductase (NADH), EC 1.3.1.9.
imported from: chebi.owl
has cross-reference: Wikipedia:Enoyl-acyl_carrier_protein_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitors
has_related_synonym: EC 1.3.1.9 inhibitor
has_related_synonym: EC 1.3.1.9 inhibitors
has_related_synonym: ENR inhibitor
has_related_synonym: ENR inhibitors
has_related_synonym: NADH-enoyl acyl carrier protein reductase inhibitor
has_related_synonym: NADH-enoyl acyl carrier protein reductase inhibitors
has_related_synonym: NADH-specific enoyl-ACP reductase inhibitor
has_related_synonym: NADH-specific enoyl-ACP reductase inhibitors
has_related_synonym: acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitor
has_related_synonym: acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitors
has_related_synonym: enoyl-ACP reductase inhibitor
has_related_synonym: enoyl-ACP reductase inhibitors
has_related_synonym: enoyl-[acyl carrier protein] reductase inhibitor
has_related_synonym: enoyl-[acyl carrier protein] reductase inhibitors
id: CHEBI:139512
in subset: 3 STAR

EC 4.1.1.17 (ornithine decarboxylase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of ornithine decarboxylase (EC 4.1.1.17).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.1.1.17 (ornithine decarboxylase) inhibitors
has_related_synonym: EC 4.1.1.17 inhibitor
has_related_synonym: EC 4.1.1.17 inhibitors
has_related_synonym: L-ornithine carboxy-lyase (putrescine-forming) inhibitor
has_related_synonym: L-ornithine carboxy-lyase (putrescine-forming) inhibitors
has_related_synonym: L-ornithine carboxy-lyase inhibitor
has_related_synonym: L-ornithine carboxy-lyase inhibitors
has_related_synonym: ODC inhibitor
has_related_synonym: ODC inhibitors
has_related_synonym: SpeC inhibitor
has_related_synonym: SpeC inhibitors
id: CHEBI:139556
in subset: 3 STAR

Jacobaea metabolite
type: Class
subclass of: plant metabolite
textual definition: Any plant metabolite that is produced by the genus Jacobaea.
imported from: chebi.owl
has cross-reference: Wikipedia:Jacobaea
has_obo_namespace: chebi_ontology
has_related_synonym: Jacobaea metabolites
id: CHEBI:139566
in subset: 3 STAR

lysophosphatidic acid receptor 3 agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates lysophosphatidic acid 3 receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:LPAR3
has_obo_namespace: chebi_ontology
has_related_synonym: LPA3 agonist
has_related_synonym: LPA3 agonists
has_related_synonym: LPAR3 agonist
has_related_synonym: LPAR3 agonists
has_related_synonym: lysophosphatidic acid receptor 3 agonists
id: CHEBI:139584
in subset: 3 STAR

survivin suppressant
type: Class
subclass of: apoptosis inducer
textual definition: An apoptosis inducer that works by selectively inhibiting survivin (BIRC5) gene promoter activity so as to down-regulate survivin, a protein that inhibits apoptosis, so leading to induction of apoptosis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: survivin suppressants
has_related_synonym: survivin suppressor
has_related_synonym: survivin suppressors
id: CHEBI:139609
in subset: 3 STAR

TRPV4 agonist
type: Class
subclass of: agonist
textual definition: An agonist at the transient receptor potential vanilloid 4 (TRPV4).
imported from: chebi.owl
has cross-reference: Wikipedia:TRPV4
has_obo_namespace: chebi_ontology
has_related_synonym: OSM9-like transient receptor potential channel, member 4 agonist
has_related_synonym: OSM9-like transient receptor potential channel, member 4 agonists
has_related_synonym: OTRPC4 agonist
has_related_synonym: OTRPC4 agonists
has_related_synonym: TRPV4 agonists
has_related_synonym: VR-OAC agonist
has_related_synonym: VR-OAC agonists
has_related_synonym: transient receptor potential +agonist
has_related_synonym: transient receptor potential cation channel subfamily V member 4 agonist
has_related_synonym: transient receptor potential cation channel subfamily V member 4 agonists
has_related_synonym: transient receptor potential vanilloid 4 agonists
has_related_synonym: transient receptor vanilloid-4 agonist
has_related_synonym: transient receptor vanilloid-4 agonists
has_related_synonym: vanilloid-receptor related osmotically activated channel agonist
has_related_synonym: vanilloid-receptor related osmotically activated channel agonists
id: CHEBI:140061
in subset: 3 STAR

Camellia sinensis metabolite
type: Class
subclass of: plant metabolite
textual definition: Any plant metabolite that is produced by Camellia sinensis.
imported from: chebi.owl
has cross-reference: Wikipedia:Camellia_sinensis
has_obo_namespace: chebi_ontology
has_related_synonym: C. sinensis metabolite
has_related_synonym: C. sinensis metabolites
has_related_synonym: Camellia sinensis metabolites
id: CHEBI:140160
in subset: 3 STAR

Brassica napus metabolite
type: Class
subclass of: plant metabolite
textual definition: Any plant metabolite that is produced by rapeseed (Brassica napus).
imported from: chebi.owl
has cross-reference: Wikipedia:Rapeseed
has_obo_namespace: chebi_ontology
has_related_synonym: Brassica napus metabolites
has_related_synonym: rapeseed metabolite
has_related_synonym: rapeseed metabolites
id: CHEBI:140165
in subset: 3 STAR

calcium-dependent antibiotics
type: Class
subclass of: antimicrobial agent
textual definition: Any antimicrobial agent whose activity is dependent on the presence of calcium ions.
imported from: chebi.owl
has cross-reference: PMID:18489906
has cross-reference: PMID:22711659
has cross-reference: PMID:29108098
has cross-reference: PMID:29434326
has_obo_namespace: chebi_ontology
has_related_synonym: Ca(2+)-dependent antibiotic
has_related_synonym: Ca(2+)-dependent antibiotics
has_related_synonym: Ca-dependent antibiotic
has_related_synonym: Ca-dependent antibiotics
has_related_synonym: calcium-dependent antibiotic
id: CHEBI:140190
in subset: 3 STAR

EC 1.1.1.37 (malate dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of any malate dehydrogenase (EC 1.1.1.37).
imported from: chebi.owl
has cross-reference: PMID:559534
has cross-reference: Wikipedia:Malate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-malate:NAD(+) oxidoreductase inhibitor
has_related_synonym: (S)-malate:NAD(+) oxidoreductase inhibitors
has_related_synonym: EC 1.1.1.37 (malate dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.37 inhibitor
has_related_synonym: EC 1.1.1.37 inhibitors
has_related_synonym: L-malate dehydrogenase inhibitor
has_related_synonym: L-malate dehydrogenase inhibitors
has_related_synonym: L-malate-NAD(+) oxidoreductase inhibitor
has_related_synonym: L-malate-NAD(+) oxidoreductase inhibitors
has_related_synonym: MDH inhibitor
has_related_synonym: MDH inhibitors
has_related_synonym: NAD-L-malate dehydrogenase inhibitor
has_related_synonym: NAD-L-malate dehydrogenase inhibitors
has_related_synonym: NAD-dependent malate dehydrogenase inhibitor
has_related_synonym: NAD-dependent malate dehydrogenase inhibitors
has_related_synonym: NAD-dependent malic dehydrogenase inhibitor
has_related_synonym: NAD-dependent malic dehydrogenase inhibitors
has_related_synonym: NAD-linked malate dehydrogenase inhibitor
has_related_synonym: NAD-linked malate dehydrogenase inhibitors
has_related_synonym: NAD-malate dehydrogenase inhibitor
has_related_synonym: NAD-malate dehydrogenase inhibitors
has_related_synonym: NAD-malic dehydrogenase inhibitor
has_related_synonym: NAD-malic dehydrogenase inhibitors
has_related_synonym: NAD-specific malate dehydrogenase inhibitor
has_related_synonym: NAD-specific malate dehydrogenase inhibitors
has_related_synonym: malate (NAD) dehydrogenase inhibitor
has_related_synonym: malate (NAD) dehydrogenase inhibitors
has_related_synonym: malate dehydrogenase (EC 1.1.1.37) inhibitor
has_related_synonym: malate dehydrogenase (EC 1.1.1.37) inhibitors
has_related_synonym: malate dehydrogenase inhibitor
has_related_synonym: malate dehydrogenase inhibitors
has_related_synonym: malic acid dehydrogenase inhibitor
has_related_synonym: malic acid dehydrogenase inhibitors
has_related_synonym: malic dehydrogenase inhibitor
has_related_synonym: malic dehydrogenase inhibitors
id: CHEBI:140378
in subset: 3 STAR

specialised pro-resolving mediator
type: Class
subclass of: biological role
subclass of: signalling molecule
subclass of: anti-inflammatory agent
textual definition: A class of cell signaling molecules enzymatically derived from n-3 long chain polyunsaturated fatty acids that have important roles in orchestrating the resolution of tissue inflammation.
imported from: chebi.owl
has cross-reference: Wikipedia:Specialized_pro-resolving_mediators
has_obo_namespace: chebi_ontology
has_related_synonym: SPM
has_related_synonym: SPMs
has_related_synonym: specialised pro-resolving mediators
has_related_synonym: specialised proresolving mediator
has_related_synonym: specialised proresolving mediators
has_related_synonym: specialized pro-resolving mediator
has_related_synonym: specialized pro-resolving mediators
has_related_synonym: specialized proresolving mediator
has_related_synonym: specialized proresolving mediators
id: CHEBI:140399
in subset: 3 STAR

neurokinin-3 receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the neurokinin-3 receptor.
imported from: chebi.owl
has cross-reference: PMID:25107588
has cross-reference: Wikipedia:Tachykinin_receptor_3
has_obo_namespace: chebi_ontology
has_related_synonym: NK-3 receptor antagonist
has_related_synonym: NK-3 receptor antagonists
has_related_synonym: NK3 receptor antagonist
has_related_synonym: NK3 receptor antagonists
has_related_synonym: NK3R antagonist
has_related_synonym: NK3R antagonists
has_related_synonym: TACR3 antagonist
has_related_synonym: TACR3 antagonists
has_related_synonym: neurokinin-3 receptor antagonists
has_related_synonym: tachykinin receptor 3 antagonist
has_related_synonym: tachykinin receptor 3 antagonists
id: CHEBI:140482
in subset: 3 STAR

tropomyosin-related kinase B receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and deactivates the tropomyosin-related kinase B (TrkB) receptor, the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
imported from: chebi.owl
has cross-reference: Wikipedia:Tropomyosin_receptor_kinase_B
has_obo_namespace: chebi_ontology
has_related_synonym: TrkB receptor agonist
has_related_synonym: TrkB receptor agonists
has_related_synonym: tropomyosin-related kinase B receptor agonists
id: CHEBI:140489
in subset: 3 STAR

TRPV1 agonist
type: Class
subclass of: agonist
textual definition: An agonist at the transient receptor potential vanilloid 1 (TRPV1).
imported from: chebi.owl
has cross-reference: Wikipedia:TRPV1
has_obo_namespace: chebi_ontology
has_related_synonym: TRPV1 agonists
has_related_synonym: capsaicin receptor agonist
has_related_synonym: capsaicin receptor agonists
has_related_synonym: transient receptor potential cation channel subfamily V member 1 agonist
has_related_synonym: transient receptor potential cation channel subfamily V member 1 agonists
has_related_synonym: transient receptor potential vanilloid 1 agonist
has_related_synonym: transient receptor potential vanilloid 1 agonists
has_related_synonym: vanilloid receptor 1 agonist
has_related_synonym: vanilloid receptor 1 agonists
id: CHEBI:140535
in subset: 3 STAR

Arabidopsis thaliana metabolite
type: Class
subclass of: plant metabolite
textual definition: Any plant metabolite that is produced by Arabidopsis thaliana.
imported from: chebi.owl
has cross-reference: Wikipedia:Arabidopsis_thaliana
has_obo_namespace: chebi_ontology
has_related_synonym: Arabidopsis thaliana metabolites
id: CHEBI:140602
in subset: 3 STAR

secreted frizzled-related protein 1 inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor of secreted frizzled-related protein 1 (SFRP1). The level of SFRP1 affects osteoblast apoptosis and proliferation, so SFRP1 inhibitors have the potential to be used for the treatment of osteoporosis or other bone related disorders.
imported from: chebi.owl
has cross-reference: PMID:19053830
has cross-reference: PMID:19819694
has cross-reference: Wikipedia:Secreted_frizzled-related_protein_1
has_obo_namespace: chebi_ontology
has_related_synonym: SFRP1 inhibitor
has_related_synonym: SFRP1 inhibitors
has_related_synonym: sFRP-1 inhibitor
has_related_synonym: sFRP-1 inhibitors
has_related_synonym: secreted frizzled-related protein 1 inhibitors
has_related_synonym: secreted frizzled-related protein-1 inhibitor
has_related_synonym: secreted frizzled-related protein-1 inhibitors
id: CHEBI:140701
in subset: 3 STAR

Hedgehog signaling pathway inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: Any pathway inhibitor that inhibits the Hedgehog signalling pathway.
imported from: chebi.owl
has cross-reference: Wikipedia:Hedgehog_pathway_inhibitors
has_obo_namespace: chebi_ontology
has_related_synonym: Hedgehog pathway inhibitor
has_related_synonym: Hedgehog pathway inhibitors
has_related_synonym: Hedgehog signaling pathway inhibitors
id: CHEBI:140921
in subset: 3 STAR

glioma-associated oncogene inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor of any of the glioma-associated oncogene (GLI) proteins.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GLI inhibitor
has_related_synonym: GLI inhibitors
has_related_synonym: glioma-associated oncogene inhibitors
id: CHEBI:140922
in subset: 3 STAR

neuropeptide FF receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates neuropeptide FF receptors.
imported from: chebi.owl
has cross-reference: PMID:26896564
has cross-reference: Wikipedia:Neuropeptide_FF
has_obo_namespace: chebi_ontology
has_related_synonym: NPFF receptor antagonist
has_related_synonym: NPFF receptor antagonists
has_related_synonym: NPFFR antagonist
has_related_synonym: NPFFR antagonists
has_related_synonym: neuropeptide FF receptor antagonists
id: CHEBI:140982
in subset: 3 STAR

neuropeptide FF receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that activates neuropeptide FF (NPFF) receptors.
imported from: chebi.owl
has cross-reference: PMID:26896564
has cross-reference: Wikipedia:Neuropeptide_FF
has_obo_namespace: chebi_ontology
has_related_synonym: NPFF receptor agonist
has_related_synonym: NPFF receptor agonists
has_related_synonym: neuropeptide FF receptor agonists
id: CHEBI:141000
in subset: 3 STAR

kisspeptin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that acts at the kisspeptin receptor (KISS1R).
imported from: chebi.owl
has cross-reference: Wikipedia:KiSS1-derived_peptide_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: kisspeptin receptor agonists
id: CHEBI:141001
in subset: 3 STAR

quinone outside inhibitor
type: Class
subclass of: fungicide
subclass of: mitochondrial cytochrome-bc1 complex inhibitor
textual definition: A mitochondrial cytochrome-bc1 complex inhibitor that acts at the Quinone 'outer' (Qo) binding site of the cytochrome-bc1 complex.
imported from: chebi.owl
has cross-reference: Wikipedia:QoI
has_obo_namespace: chebi_ontology
has_related_synonym: QOI
has_related_synonym: QOIs
has_related_synonym: Qo inhibitor
has_related_synonym: Qo inhibitors
has_related_synonym: quinone outside inhibitors
id: CHEBI:141153
in subset: 3 STAR

pronematicide
type: Class
subclass of: propesticide
subclass of: nematicide
textual definition: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active nematicide for which it is a pronematicide.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pronematicides
has_related_synonym: pronematocide
has_related_synonym: pronematocides
id: CHEBI:141301
in subset: 3 STAR

5-hydroxytryptamine 2B receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist at the 5-hydroxytryptamine 2B (5-HT2B) receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 5-HT2B agonist
has_related_synonym: 5-HT2B agonists
has_related_synonym: 5-HT2B receptor agonist
has_related_synonym: 5-HT2B receptor agonists
has_related_synonym: 5-hydroxytryptamine 2B receptor agonists
has_related_synonym: 5-hydroxytryptamine receptor 2B agonist
has_related_synonym: 5-hydroxytryptamine receptor 2B agonists
has_related_synonym: serotonin receptor 2B agonist
has_related_synonym: serotonin receptor 2B agonists
id: CHEBI:142184
in subset: 3 STAR

5-hydroxytryptamine 2C receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist at the 5-hydroxytryptamine 2B (5-HT2C) receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 5-HT2C receptor agonist
has_related_synonym: 5-HT2C receptor agonists
has_related_synonym: 5-HT2c agonist
has_related_synonym: 5-HT2c agonists
has_related_synonym: 5-hydroxytryptamine 2C receptor agonists
has_related_synonym: 5-hydroxytryptamine receptor 2C agonist
has_related_synonym: 5-hydroxytryptamine receptor 2C agonists
has_related_synonym: serotonin receptor 2C agonist
has_related_synonym: serotonin receptor 2C agonists
id: CHEBI:142185
in subset: 3 STAR

EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
textual definition: Any EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of leukotriene-B4 20-monooxygenase (EC 1.14.14.94).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating) inhibitor
has_related_synonym: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating) inhibitors
has_related_synonym: CYP4F2 inhibitor
has_related_synonym: CYP4F2 inhibitors
has_related_synonym: CYP4F3 inhibitor
has_related_synonym: CYP4F3 inhibitors
has_related_synonym: EC 1.14.13.30 inhibitor
has_related_synonym: EC 1.14.13.30 inhibitors
has_related_synonym: EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitors
has_related_synonym: EC 1.14.14.94 inhibitor
has_related_synonym: EC 1.14.14.94 inhibitors
has_related_synonym: LTB4 20-hydroxylase inhibitor
has_related_synonym: LTB4 20-hydroxylase inhibitors
has_related_synonym: LTB4 omega-hydroxylase inhibitor
has_related_synonym: LTB4 omega-hydroxylase inhibitors
has_related_synonym: leucotriene-B4 omega-hydroxylase inhibitor
has_related_synonym: leucotriene-B4 omega-hydroxylase inhibitors
has_related_synonym: leukotriene-B4 20-hydroxylase inhibitor
has_related_synonym: leukotriene-B4 20-hydroxylase inhibitors
has_related_synonym: leukotriene-B4 20-monooxygenase (EC 1.14.14.94) inhibitors
has_related_synonym: leukotriene-B4 20-monooxygenase inhibitor
has_related_synonym: leukotriene-B4 20-monooxygenase inhibitors
id: CHEBI:142480
in subset: 3 STAR

EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor
textual definition: Any EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor that interferes with the action of alkane 1-monooxygenase (EC 1.14.15.3).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 1-hydroxylase inhibitor
has_related_synonym: 1-hydroxylase inhibitors
has_related_synonym: EC 1.14.15.3 (alkane 1-monooxygenase) inhibitors
has_related_synonym: EC 1.14.15.3 inhibitor
has_related_synonym: EC 1.14.15.3 inhibitors
has_related_synonym: alkane 1-hydroxylase inhibitor
has_related_synonym: alkane 1-hydroxylase inhibitors
has_related_synonym: alkane 1-monooxygenase (EC 1.14.15.3) inhibitor
has_related_synonym: alkane 1-monooxygenase (EC 1.14.15.3) inhibitors
has_related_synonym: alkane 1-monooxygenase inhibitor
has_related_synonym: alkane 1-monooxygenase inhibitors
has_related_synonym: alkane hydroxylase inhibitor
has_related_synonym: alkane hydroxylase inhibitors
has_related_synonym: alkane monooxygenase inhibitor
has_related_synonym: alkane monooxygenase inhibitors
has_related_synonym: alkane,reduced-rubredoxin:oxygen 1-oxidoreductase inhibitor
has_related_synonym: alkane,reduced-rubredoxin:oxygen 1-oxidoreductase inhibitors
has_related_synonym: fatty acid omega-hydroxylase inhibitor
has_related_synonym: fatty acid omega-hydroxylase inhibitors
has_related_synonym: omega-hydroxylase inhibitor
has_related_synonym: omega-hydroxylase inhibitors
id: CHEBI:142481
in subset: 3 STAR

EC 4.1.1.15 (glutamate decarboxylase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of glutamate decarboxylase (EC 4.1.1.15).
imported from: chebi.owl
has cross-reference: Wikipedia:Glutamate_decarboxylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.1.1.15 (glutamate decarboxylase) inhibitors
has_related_synonym: EC 4.1.1.15 inhibitor
has_related_synonym: EC 4.1.1.15 inhibitors
has_related_synonym: L-aspartate-alpha-decarboxylase inhibitor
has_related_synonym: L-aspartate-alpha-decarboxylase inhibitors
has_related_synonym: L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) inhibitor
has_related_synonym: L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) inhibitors
has_related_synonym: L-glutamate 1-carboxy-lyase inhibitor
has_related_synonym: L-glutamate 1-carboxy-lyase inhibitors
has_related_synonym: L-glutamate alpha-decarboxylase inhibitor
has_related_synonym: L-glutamate alpha-decarboxylase inhibitors
has_related_synonym: L-glutamic acid decarboxylase inhibitor
has_related_synonym: L-glutamic acid decarboxylase inhibitors
has_related_synonym: L-glutamic decarboxylase inhibitor
has_related_synonym: L-glutamic decarboxylase inhibitors
has_related_synonym: aspartate 1-decarboxylase inhibitor
has_related_synonym: aspartate 1-decarboxylase inhibitors
has_related_synonym: aspartic alpha-decarboxylase inhibitor
has_related_synonym: aspartic alpha-decarboxylase inhibitors
has_related_synonym: cysteic acid decarboxylase inhibitor
has_related_synonym: cysteic acid decarboxylase inhibitors
has_related_synonym: gamma-glutamate decarboxylase inhibitor
has_related_synonym: gamma-glutamate decarboxylase inhibitors
has_related_synonym: glutamate decarboxylase (EC 4.1.1.15) inhibitor
has_related_synonym: glutamate decarboxylase (EC 4.1.1.15) inhibitors
has_related_synonym: glutamate decarboxylase inhibitor
has_related_synonym: glutamate decarboxylase inhibitors
id: CHEBI:142581
in subset: 3 STAR

tau aggregation inhibitor
type: Class
subclass of: inhibitor
textual definition: A chemical that inhibits the aggregation of the tau protein (HGNC:MAPT) and its distinct morphological forms (e.g. paired helical fragments (PHFs), straight filaments (SFs), oligomers, or larger aggregates).
imported from: chebi.owl
has cross-reference: PMID:19164903
has cross-reference: PMID:19189357
has cross-reference: PMID:20149808
has cross-reference: PMID:23484434
has cross-reference: PMID:24072703
has cross-reference: PMID:25387336
has cross-reference: PMID:26809554
has cross-reference: PMID:27975248
has cross-reference: Wikipedia:Tau_protein
alternative_term: tau aggregation inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: TAI
has_related_synonym: tau aggregation inhibitors
has_related_synonym: tau protein aggregation inhibitor
has_related_synonym: tau protein aggregation inhibitors
has_related_synonym: tau-aggregation inhibitor
has_related_synonym: tau-aggregation inhibitors
id: CHEBI:142738
in subset: 3 STAR

EC 2.5.1.117 (homogentisate solanesyltransferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:142781
in subset: 1 STAR

TRPV channel modulator
type: Class
subclass of: TRP channel modulator
textual definition: Any transient receptor potential (TRP) channel modulator that modulates the TRPV channels (V = vanilloid). There is strong evidence that action at one or more of this class of proteins is responsible for the insecticidal action of pymetrozine, pyrifluquinazon, and afidopyropen.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: TRPV channel modulators
has_related_synonym: transient receptor potential (vanilloid) channel modulator
has_related_synonym: transient receptor potential (vanilloid) channel modulators
id: CHEBI:142782
in subset: 3 STAR

TRP channel modulator
type: Class
subclass of: membrane transport modulator
textual definition: An agent that modulates the passage of cations through the transient receptor potential (TRP) channels.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: TRP channel modulators
id: CHEBI:142783
in subset: 3 STAR

EC 3.3.2.10 (soluble epoxide hydrolase) inhibitor
type: Class
subclass of: EC 3.3.* (ether hydrolase) inhibitor
textual definition: Any inhibitor of soluble epoxide hydrolase, a bifunctional enzyme that in humans is encoded by the EPHX2 gene.Found in both the cytosol and peroxisomes it binds to specific epoxides and converts them into the corresponding diols.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sEHi
has_related_synonym: soluble epoxide hydrolase inhibitor
has_related_synonym: soluble epoxide hydrolase inhibitors
id: CHEBI:142790
in subset: 3 STAR

GABAB receptor agonist
type: Class
subclass of: GABA agonist
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:143001
in subset: 1 STAR

EC 2.1.3.* (carboxy- and carbamoyltransferases) inhibitor
type: Class
subclass of: EC 2.1.* (C1-transferase) inhibitor
textual definition: An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any carboxy- and carbamoyltransferases (EC 2.1.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.1.3.* (carboxy- and carbamoyltransferases) inhibitors
has_related_synonym: EC 2.1.3.* (carboxytransferase and carbamoyltransferase) inhibitor
has_related_synonym: EC 2.1.3.* (carboxytransferase and carbamoyltransferase) inhibitors
has_related_synonym: EC 2.1.3.* inhibitor
has_related_synonym: EC 2.1.3.* inhibitors
has_related_synonym: carboxy- and carbamoyltransferase (EC 2.1.3.*) inhibitor
has_related_synonym: carboxy- and carbamoyltransferase (EC 2.1.3.*) inhibitors
id: CHEBI:143002
in subset: 3 STAR

EC 2.1.3.3 (ornithine carbamoyltransferase) inhibitor
type: Class
subclass of: EC 2.1.3.* (carboxy- and carbamoyltransferases) inhibitor
textual definition: Any EC 2.1.3.* (carboxy- and carbamoyltransferases) inhibitor that inhibits the action of ornithine carbamoyltransferase (EC 2.1.3.3).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.1.3.3 (ornithine carbamoyltransferase) inhibitors
has_related_synonym: EC 2.1.3.3 inhibitor
has_related_synonym: EC 2.1.3.3 inhibitors
has_related_synonym: L-ornithine carbamoyltransferase inhibitor
has_related_synonym: L-ornithine carbamoyltransferase inhibitors
has_related_synonym: L-ornithine carbamyltransferase inhibitor
has_related_synonym: L-ornithine carbamyltransferase inhibitors
has_related_synonym: L-ornithine transcarbamylase inhibitor
has_related_synonym: L-ornithine transcarbamylase inhibitors
has_related_synonym: OTC inhibitor
has_related_synonym: OTC inhibitors
has_related_synonym: carbamoyl-phosphate:L-ornithine carbamoyltransferase inhibitor
has_related_synonym: carbamoyl-phosphate:L-ornithine carbamoyltransferase inhibitors
has_related_synonym: carbamylphosphate-ornithine transcarbamylase inhibitor
has_related_synonym: carbamylphosphate-ornithine transcarbamylase inhibitors
has_related_synonym: citrulline phosphorylase inhibitor
has_related_synonym: citrulline phosphorylase inhibitors
has_related_synonym: ornithine carbamoyltransferase (EC 2.1.3.3) inhibitor
has_related_synonym: ornithine carbamoyltransferase (EC 2.1.3.3) inhibitors
has_related_synonym: ornithine carbamoyltransferase inhibitor
has_related_synonym: ornithine carbamoyltransferase inhibitors
has_related_synonym: ornithine carbamyltransferase inhibitor
has_related_synonym: ornithine carbamyltransferase inhibitors
has_related_synonym: ornithine transcarbamylase inhibitor
has_related_synonym: ornithine transcarbamylase inhibitors
id: CHEBI:143003
in subset: 3 STAR

impurity
type: Class
subclass of: chemical role
textual definition: A chemical role played by any unwanted chemical substance inside a confined amount of liquid, gas, or solid, which differs from the chemical composition of the material or compound. For example, an impurity can be an undesired by-product of a chemical reaction or manufacturing process, a drug contaminant, or can be created upon degradation during storage.
imported from: chebi.owl
has cross-reference: Wikipedia:Impurity
alternative_term: impurity
has_obo_namespace: chebi_ontology
has_related_synonym: contaminant
has_related_synonym: contaminants
has_related_synonym: impurities
id: CHEBI:143130
in subset: 3 STAR

peptide allergen
type: Class
subclass of: allergen
textual definition: Any peptide which causes the onset of an allergic reaction.
imported from: chebi.owl
has cross-reference: PMID:12531657
has cross-reference: PMID:13966695
has cross-reference: PMID:2045614
has cross-reference: PMID:6423971
has cross-reference: PMID:6681826
has cross-reference: PMID:7549111
has cross-reference: Patent:EP0650976
has cross-reference: Patent:WO9404572
has_obo_namespace: chebi_ontology
has_related_synonym: allergenic peptide
id: CHEBI:143204
in subset: 3 STAR

carbohydrate allergen
type: Class
subclass of: allergen
textual definition: Any carbohydrate, carbohydrate derivative or derived substituent group which causes the onset of an allergic reaction.
imported from: chebi.owl
has cross-reference: PMID:9788708
has_obo_namespace: chebi_ontology
has_related_synonym: allergenic carbohydrate
has_related_synonym: allergenic carbohydrate derivative
id: CHEBI:143231
in subset: 3 STAR

ceramide allergen
type: Class
subclass of: allergen
textual definition: Any ceramide which causes the onset of an allergic reaction.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: allergenic ceramide
id: CHEBI:143252
in subset: 3 STAR

EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor
type: Class
subclass of: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
textual definition: Any EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of sterol 14alpha-demethylase (EC 1.14.14.154).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CYP51 inhibitor
has_related_synonym: CYP51 inhibitors
has_related_synonym: EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitors
has_related_synonym: EC 1.14.14.154 inhibitor
has_related_synonym: EC 1.14.14.154 inhibitors
has_related_synonym: ERG11 inhibitor
has_related_synonym: ERG11 inhibitors
has_related_synonym: cytochrome P450 51 inhibitor
has_related_synonym: cytochrome P450 51 inhibitors
has_related_synonym: lanosterol 14-demethylase inhibitor
has_related_synonym: lanosterol 14-demethylase inhibitors
has_related_synonym: lanosterol 14alpha-demethylase inhibitor
has_related_synonym: lanosterol 14alpha-demethylase inhibitors
has_related_synonym: obtusufoliol 14-demethylase inhibitor
has_related_synonym: obtusufoliol 14-demethylase inhibitors
has_related_synonym: oxidoreductase (14-methyl cleaving) inhibitors
has_related_synonym: sterol 14-demethylase inhibitor
has_related_synonym: sterol 14-demethylase inhibitors
has_related_synonym: sterol 14alpha-demethylase (EC 1.14.14.154) inhibitor
has_related_synonym: sterol 14alpha-demethylase (EC 1.14.14.154) inhibitors
has_related_synonym: sterol 14alpha-demethylase inhibitor
has_related_synonym: sterol 14alpha-demethylase inhibitors
has_related_synonym: sterol,[reduced NADPH--hemoprotein reductase]:oxygen inhibitor
has_related_synonym: sterol,[reduced NADPH--hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) inhibitor
id: CHEBI:143828
in subset: 3 STAR

EC 2.7.1.40 (pyruvate kinase) inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of pyruvate kinase (EC 2.7.1.40).
imported from: chebi.owl
has cross-reference: Wikipedia:Pyruvate_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.1.40 inhibitor
has_related_synonym: EC 2.7.1.40 inhibitors
has_related_synonym: phosphoenol transphosphorylase inhibitor
has_related_synonym: phosphoenol transphosphorylase inhibitors
has_related_synonym: phosphoenolpyruvate kinase inhibitor
has_related_synonym: phosphoenolpyruvate kinase inhibitors
has_related_synonym: pyruvate kinase inhibitor
has_related_synonym: pyruvate kinase inhibitors
id: CHEBI:143909
in subset: 3 STAR

EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) inhibitor
type: Class
subclass of: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor
textual definition: Any EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor that interferes with the action of cholesterol monooxygenase (side-chain-cleaving) (EC 1.14.15.6).
imported from: chebi.owl
has cross-reference: Wikipedia:Cholesterol_side-chain_cleavage_enzyme
has_obo_namespace: chebi_ontology
has_related_synonym: C27-side chain cleavage enzyme inhibitor
has_related_synonym: C27-side chain cleavage enzyme inhibitors
has_related_synonym: EC 1.14.15.6 inhibitor
has_related_synonym: EC 1.14.15.6 inhibitors
has_related_synonym: cholesterol 20-22-desmolase inhibitor
has_related_synonym: cholesterol 20-22-desmolase inhibitors
has_related_synonym: cholesterol C20-22 desmolase inhibitor
has_related_synonym: cholesterol C20-22 desmolase inhibitors
has_related_synonym: cholesterol desmolase inhibitor
has_related_synonym: cholesterol desmolase inhibitors
has_related_synonym: cholesterol monooxygenase (side-chain-cleaving) inhibitor
has_related_synonym: cholesterol monooxygenase (side-chain-cleaving) inhibitors
has_related_synonym: cholesterol side-chain cleavage enzyme inhibitor
has_related_synonym: cholesterol side-chain cleavage enzyme inhibitors
has_related_synonym: cholesterol side-chain-cleaving enzyme inhibitor
has_related_synonym: cholesterol side-chain-cleaving enzyme inhibitors
has_related_synonym: cytochrome P-450scc inhibitor
has_related_synonym: cytochrome P-450scc inhibitors
has_related_synonym: steroid 20-22 desmolase inhibitor
has_related_synonym: steroid 20-22 desmolase inhibitors
has_related_synonym: steroid 20-22-lyase inhibitor
has_related_synonym: steroid 20-22-lyase inhibitors
id: CHEBI:144064
in subset: 3 STAR

EC 1.4.3.2 (L-amino-acid oxidase) inhibitor
type: Class
subclass of: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor
textual definition: Any EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of L-amino-acid oxidase (EC 1.4.3.2).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.3.2 (L-amino-acid oxidase) inhibitors
has_related_synonym: EC 1.4.3.2 inhibitor
has_related_synonym: EC 1.4.3.2 inhibitors
has_related_synonym: L-amino-acid oxidase inhibitor
has_related_synonym: L-amino-acid oxidase inhibitor (EC 1.4.3.2) inhibitor
has_related_synonym: L-amino-acid oxidase inhibitor (EC 1.4.3.2) inhibitors
has_related_synonym: L-amino-acid oxidase inhibitors
has_related_synonym: L-amino-acid:oxygen oxidoreductase (deaminating) inhibitor
has_related_synonym: L-amino-acid:oxygen oxidoreductase (deaminating) inhibitors
has_related_synonym: ophio-amino-acid oxidase inhibitor
has_related_synonym: ophio-amino-acid oxidase inhibitors
id: CHEBI:144097
in subset: 3 STAR

EC 2.6.1.2 (alanine transaminase) inhibitor
type: Class
subclass of: EC 2.6.1.* (transaminase) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:144099
in subset: 1 STAR

EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of 6-phosphofructo-2-kinase (EC 2.7.1.105).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: (6-phosphofructo-2-kinase) inhibitors
has_related_synonym: 6-phosphofructo-2-kinase (phosphorylating) inhibitor
has_related_synonym: 6-phosphofructo-2-kinase (phosphorylating) inhibitors
has_related_synonym: 6-phosphofructo-2-kinase inhibitor
has_related_synonym: 6-phosphofructo-2-kinase inhibitors
has_related_synonym: 6-phosphofructose 2-kinase inhibitor
has_related_synonym: 6-phosphofructose 2-kinase inhibitors
has_related_synonym: EC 2.7.1.105 inhibitor
has_related_synonym: EC 2.7.1.105 inhibitors
has_related_synonym: fructose 6-phosphate 2-kinase inhibitor
has_related_synonym: fructose 6-phosphate 2-kinase inhibitors
has_related_synonym: phosphofructokinase 2 inhibitor
has_related_synonym: phosphofructokinase 2 inhibitors
id: CHEBI:144387
in subset: 3 STAR

EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
textual definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of retinoid isomerohydrolase (EC 3.1.1.64).
imported from: chebi.owl
has cross-reference: Wikipedia:RPE65
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.1.64 (retinoid isomerohydrolase) inhibitors
has_related_synonym: EC 3.1.1.64 inhibitor
has_related_synonym: EC 3.1.1.64 inhibitors
has_related_synonym: RPE65 inhibitor
has_related_synonym: RPE65 inhibitors
has_related_synonym: all-trans-retinol isomerase:hydrolase inhibitor
has_related_synonym: all-trans-retinol isomerase:hydrolase inhibitors
has_related_synonym: all-trans-retinyl-palmitate hydrolase inhibitor
has_related_synonym: all-trans-retinyl-palmitate hydrolase inhibitors
has_related_synonym: all-trans-retinylester 11-cis isomerohydrolase inhibitor
has_related_synonym: all-trans-retinylester 11-cis isomerohydrolase inhibitors
has_related_synonym: retinoid isomerohydrolase inhibitor
has_related_synonym: retinoid isomerohydrolase inhibitors
has_related_synonym: retinol isomerase inhibitor
has_related_synonym: retinol isomerase inhibitors
id: CHEBI:144455
in subset: 3 STAR

tumour antigen
type: Class
subclass of: antigen
textual definition: An antigenic substance produced in tumour cells, which triggers an immune response in the host.
imported from: chebi.owl
has cross-reference: Wikipedia:Tumor_antigen
has_obo_namespace: chebi_ontology
has_related_synonym: tumour antigens
id: CHEBI:144829
in subset: 3 STAR

C5a receptor antagonist
type: Class
subclass of: G-protein-coupled receptor antagonist
textual definition: Any antagonist of the C5a receptor.
imported from: chebi.owl
has cross-reference: PMID:20004096
has cross-reference: PMID:23537791
has cross-reference: PMID:24117111
has cross-reference: PMID:25682062
has cross-reference: PMID:26634479
has cross-reference: PMID:28955891
has cross-reference: PMID:29802264
has cross-reference: PMID:29867214
has cross-reference: Wikipedia:C5a_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: C5AR1 antagonist
has_related_synonym: C5AR1 antagonists
has_related_synonym: C5a receptor antagonists
has_related_synonym: CD88 antagonist
has_related_synonym: CD88 antagonists
has_related_synonym: cluster of differentiation 88 antagonist
has_related_synonym: cluster of differentiation 88 antagonists
has_related_synonym: complement component 5a receptor 1 antagonist
has_related_synonym: complement component 5a receptor 1 antagonists
id: CHEBI:144895
in subset: 3 STAR

EC 3.6.5.2 (small monomeric GTPase) inhibitor
type: Class
subclass of: EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:144981
in subset: 1 STAR

sphingosine-1-phosphate receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and blocks sphingosine 1-phosphate receptors, a class of G protein-coupled receptors that are targets of the lipid signalling molecule sphingosine-1-phosphate (S1P).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EDG receptor antagonist
has_related_synonym: S1P receptor antagonist
has_related_synonym: S1P receptor antagonists
has_related_synonym: SIP antagonist
has_related_synonym: SIP antagonists
has_related_synonym: sphingosine 1-phosphate receptor antagonist
has_related_synonym: sphingosine 1-phosphate receptor antagonists
has_related_synonym: sphingosine-1-phosphate receptor antagonists
id: CHEBI:144987
in subset: 3 STAR

sphingosine-1-phosphate receptor 3 antagonist
type: Class
subclass of: sphingosine-1-phosphate receptor antagonist
textual definition: Any sphingosine-1-phosphate receptor (S1PR) antagonist that acts as an antagonist towards the subtype 3 receptors (S1PR3).
imported from: chebi.owl
has cross-reference: PMID:25910934
has cross-reference: PMID:26943364
has cross-reference: PMID:30587459
has cross-reference: PMID:30793318
has cross-reference: PMID:30972941
has cross-reference: PMID:31502430
has_obo_namespace: chebi_ontology
has_related_synonym: S1PR3 antagonist
has_related_synonym: S1PR3 antagonists
has_related_synonym: sphingosine-1-phosphate receptor 3 antagonists
id: CHEBI:144997
in subset: 3 STAR

sphingosine-1-phosphate receptor 1 antagonist
type: Class
subclass of: sphingosine-1-phosphate receptor antagonist
textual definition: Any sphingosine-1-phosphate receptor (S1PR) antagonist that acts as an antagonist for the subtype 1 receptors (S1PR1).
imported from: chebi.owl
has cross-reference: PMID:20823564
has cross-reference: PMID:21798372
has cross-reference: PMID:22214363
has cross-reference: PMID:26291341
has_obo_namespace: chebi_ontology
has_related_synonym: S1PR1 antagonist
has_related_synonym: S1PR1 antagonists
has_related_synonym: sphingosine-1-phosphate receptor 1 antagonists
id: CHEBI:144998
in subset: 3 STAR

antispermatogenic agent
type: Class
subclass of: application
textual definition: An agent that destroy spermatozoa in the male genitalia and block spermatogenesis.
imported from: chebi.owl
has cross-reference: PMID:16371305
has_obo_namespace: chebi_ontology
has_related_synonym: antispermatogenic
has_related_synonym: antispermatogenic agents
has_related_synonym: antispermatogenics
id: CHEBI:145047
in subset: 3 STAR

hyaluronan synthesis inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor that interferes with the synthesis of hyaluronic acid (HA, also known as hyaluronan).
imported from: chebi.owl
has cross-reference: PMID:15373776
has cross-reference: PMID:19444760
has cross-reference: PMID:20332231
has cross-reference: PMID:23288481
has cross-reference: PMID:23426189
has cross-reference: PMID:24141285
has cross-reference: PMID:25537799
has cross-reference: PMID:27706810
has_obo_namespace: chebi_ontology
has_related_synonym: HA synthesis inhibitor
has_related_synonym: HA synthesis inhibitors
has_related_synonym: hyaluronan synthesis inhibitors
has_related_synonym: hyaluronic acid synthesis inhibitor
has_related_synonym: hyaluronic acid synthesis inhibitors
id: CHEBI:145253
in subset: 3 STAR

EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of any isocitrate dehydrogenase (EC 1.1.1.42).
imported from: chebi.owl
has cross-reference: Wikipedia:Isocitrate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.1.42 inhibitor
has_related_synonym: EC 1.1.1.42 inhibitors
has_related_synonym: IDH inhibitor
has_related_synonym: IDH inhibitors
has_related_synonym: IDP inhibitor
has_related_synonym: IDP inhibitors
has_related_synonym: IDP1 inhibitor
has_related_synonym: IDP1 inhibitors
has_related_synonym: IDP2 inhibitor
has_related_synonym: IDP2 inhibitors
has_related_synonym: IDP3 inhibitor
has_related_synonym: IDP3 inhibitors
has_related_synonym: NADP isocitric dehydrogenase inhibitor
has_related_synonym: NADP isocitric dehydrogenase inhibitors
has_related_synonym: NADP(+)-ICDH inhibitor
has_related_synonym: NADP(+)-ICDH inhibitors
has_related_synonym: NADP(+)-IDH inhibitor
has_related_synonym: NADP(+)-IDH inhibitors
has_related_synonym: NADP(+)-linked isocitrate dehydrogenase inhibitor
has_related_synonym: NADP(+)-linked isocitrate dehydrogenase inhibitors
has_related_synonym: NADP-dependent isocitrate dehydrogenase inhibitor
has_related_synonym: NADP-dependent isocitrate dehydrogenase inhibitors
has_related_synonym: NADP-dependent isocitric dehydrogenase inhibitor
has_related_synonym: NADP-dependent isocitric dehydrogenase inhibitors
has_related_synonym: NADP-linked isocitrate dehydrogenase inhibitor
has_related_synonym: NADP-linked isocitrate dehydrogenase inhibitors
has_related_synonym: NADP-specific isocitrate dehydrogenase inhibitor
has_related_synonym: NADP-specific isocitrate dehydrogenase inhibitors
has_related_synonym: dual-cofactor-specific isocitrate dehydrogenase inhibitor
has_related_synonym: dual-cofactor-specific isocitrate dehydrogenase inhibitors
has_related_synonym: isocitrate (NADP) dehydrogenase inhibitor
has_related_synonym: isocitrate (NADP) dehydrogenase inhibitors
has_related_synonym: isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase inhibitor
has_related_synonym: isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase inhibitors
has_related_synonym: isocitrate dehydrogenase (NADP(+)) inhibitor
has_related_synonym: isocitrate dehydrogenase (NADP(+)) inhibitors
has_related_synonym: isocitrate dehydrogenase (NADP-dependent) inhibitor
has_related_synonym: isocitrate dehydrogenase (NADP-dependent) inhibitors
has_related_synonym: isocitrate dehydrogenase inhibitor
has_related_synonym: isocitrate dehydrogenase inhibitors
has_related_synonym: oxalosuccinate decarboxylase inhibitor
has_related_synonym: oxalosuccinate decarboxylase inhibitors
has_related_synonym: oxalsuccinic decarboxylase inhibitor
has_related_synonym: oxalsuccinic decarboxylase inhibitors
has_related_synonym: triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase inhibitor
has_related_synonym: triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase inhibitors
id: CHEBI:145410
in subset: 3 STAR

EC 2.7.11.21 (polo kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of any polo kinase (EC 2.7.11.21).
imported from: chebi.owl
has cross-reference: Wikipedia:Polo_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: Cdc5 inhibitor
has_related_synonym: Cdc5 inhibitors
has_related_synonym: Cdc5p inhibitor
has_related_synonym: Cdc5p inhibitors
has_related_synonym: EC 2.7.11.21 (polo kinase) inhibitors
has_related_synonym: EC 2.7.11.21 inhibitor
has_related_synonym: EC 2.7.11.21 inhibitors
has_related_synonym: PLK inhibitor
has_related_synonym: PLK inhibitors
has_related_synonym: Plk inhibitor
has_related_synonym: Plk inhibitors
has_related_synonym: Plk1 inhibitor
has_related_synonym: Plk1 inhibitors
has_related_synonym: Plo1 inhibitor
has_related_synonym: Plo1 inhibitors
has_related_synonym: STK21 inhibitor
has_related_synonym: STK21 inhibitors
has_related_synonym: polo kinase inhibitor
has_related_synonym: polo kinase inhibitors
has_related_synonym: polo serine-threonine kinase inhibitor
has_related_synonym: polo serine-threonine kinase inhibitors
has_related_synonym: polo-like kinase 1 inhibitor
has_related_synonym: polo-like kinase 1 inhibitors
has_related_synonym: polo-like kinase inhibitor
has_related_synonym: polo-like kinase inhibitors
has_related_synonym: serine/threonine-specific Drosophila kinase polo inhibitor
has_related_synonym: serine/threonine-specific Drosophila kinase polo inhibitors
id: CHEBI:145425
in subset: 3 STAR

uncoupling protein inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor that acts on uncoupling protein.
imported from: chebi.owl
has cross-reference: PMID:22420157
has cross-reference: PMID:23008094
has cross-reference: PMID:23609063
has cross-reference: PMID:24904988
has cross-reference: PMID:28089824
has cross-reference: PMID:29858912
has cross-reference: Patent:US2009258064
has cross-reference: Patent:US7510710
has_obo_namespace: chebi_ontology
has_related_synonym: UCP inhibitor
has_related_synonym: UCP inhibitors
has_related_synonym: mitochondrial uncoupling protein inhibitor
has_related_synonym: mitochondrial uncoupling protein inhibitors
has_related_synonym: uncoupling protein inhibitors
id: CHEBI:145437
in subset: 3 STAR

C-X-C chemokine receptor type 4 antagonist
type: Class
subclass of: antagonist
textual definition: An antogonist that blocks C-X-C chemokine receptor type 4 (CXCR-4).
imported from: chebi.owl
has cross-reference: Wikipedia:CXCR4
has_obo_namespace: chebi_ontology
has_related_synonym: C-X-C chemokine receptor type 4 antagonists
has_related_synonym: C-X-C motif chemokine receptor 4 antagonist
has_related_synonym: C-X-C motif chemokine receptor 4 antagonists
has_related_synonym: CD184 antagonist
has_related_synonym: CD184 antagonists
has_related_synonym: CXCR-4 antagonist
has_related_synonym: CXCR-4 antagonists
has_related_synonym: CXCR4 antagonist
has_related_synonym: CXCR4 antagonists
has_related_synonym: chemokine (C-X-C motif) receptor 4 antagonist
has_related_synonym: chemokine (C-X-C motif) receptor 4 antagonists
has_related_synonym: fusin antagonist
has_related_synonym: fusin antagonists
id: CHEBI:145438
in subset: 3 STAR

GABAA receptor antagonist
type: Class
subclass of: GABA antagonist
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:145515
in subset: 1 STAR

forkhead box protein O1 inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor that acts on forkhead box protein O1 (FOXO1).
imported from: chebi.owl
has cross-reference: PMID:20655898
has cross-reference: PMID:26239835
has cross-reference: PMID:28653156
has_obo_namespace: chebi_ontology
has_related_synonym: FOXO1 inhibitor
has_related_synonym: FOXO1 inhibitors
has_related_synonym: Foxo1 inhibitor
has_related_synonym: Foxo1 inhibitors
has_related_synonym: forkhead box protein O1 inhibitors
has_related_synonym: forkhead in rhabdomyosarcoma inhibitor
has_related_synonym: forkhead in rhabdomyosarcoma inhibitors
id: CHEBI:145807
in subset: 3 STAR

EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor
type: Class
subclass of: EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: Any EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor that inhibits the action of aspartate-semialdehyde dehydrogenase (EC 1.2.1.11).
imported from: chebi.owl
has cross-reference: PMID:14726201
has cross-reference: PMID:26404410
has cross-reference: Wikipedia:Aspartate-semialdehyde_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: ASA dehydrogenase inhibitor
has_related_synonym: ASA dehydrogenase inhibitors
has_related_synonym: EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitors
has_related_synonym: EC 1.2.1.11 inhibitor
has_related_synonym: EC 1.2.1.11 inhibitors
has_related_synonym: L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) inhibitor
has_related_synonym: L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) inhibitors
has_related_synonym: L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating) inhibitor
has_related_synonym: L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating) inhibitors
has_related_synonym: aspartate semialdehyde dehydrogenase inhibitor
has_related_synonym: aspartate semialdehyde dehydrogenase inhibitors
has_related_synonym: aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) inhibitor
has_related_synonym: aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) inhibitors
has_related_synonym: aspartate-semialdehyde dehydrogenase inhibitor
has_related_synonym: aspartate-semialdehyde dehydrogenase inhibitors
has_related_synonym: aspartic beta-semialdehyde dehydrogenase inhibitor
has_related_synonym: aspartic beta-semialdehyde dehydrogenase inhibitors
has_related_synonym: aspartic semialdehyde dehydrogenase inhibitor
has_related_synonym: aspartic semialdehyde dehydrogenase inhibitors
id: CHEBI:145814
in subset: 3 STAR

antiatherosclerotic agent
type: Class
subclass of: cardiovascular drug
textual definition: A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.
imported from: chebi.owl
alternative_term: antiatherosclerotic agent
has_obo_namespace: chebi_ontology
has_related_synonym: anti-atherosclerotic agent
has_related_synonym: anti-atherosclerotic agents
has_related_synonym: anti-atherosclerotic drug
has_related_synonym: anti-atherosclerotic drugs
has_related_synonym: antiatherosclerotic agents
has_related_synonym: antiatherosclerotic drug
has_related_synonym: antiatherosclerotic drugs
id: CHEBI:145947
in subset: 3 STAR

5-hydroxytryptamine 2A receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist at the 5-hydroxytryptamine 2A (5-HT2A) receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 5-HT2A agonist
has_related_synonym: 5-HT2A agonists
has_related_synonym: 5-HT2A receptor agonist
has_related_synonym: 5-HT2A receptor agonists
has_related_synonym: 5-hydroxytryptamine 2A receptor agonists
has_related_synonym: 5-hydroxytryptamine receptor 2A agonist
has_related_synonym: 5-hydroxytryptamine receptor 2A agonists
has_related_synonym: serotonin receptor 2A agonist
has_related_synonym: serotonin receptor 2A agonists
id: CHEBI:145982
in subset: 3 STAR

ryanoid insecticide
type: Class
subclass of: insecticide
subclass of: ryanodine receptor modulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:146222
in subset: 1 STAR

ryanodine receptor antagonist
type: Class
subclass of: ryanodine receptor modulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:146223
in subset: 1 STAR

CB2 receptor agonist
type: Class
subclass of: cannabinoid receptor agonist
textual definition: A cannabinoid receptor agonist that binds to and activates type 2 cannabinoid receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Cannabinoid_receptor_type_2
alternative_term: CB2 receptor agonist
has_obo_namespace: chebi_ontology
has_related_synonym: CB2 receptor agonists
has_related_synonym: CB2R agonist
has_related_synonym: CB2R agonists
has_related_synonym: cannabinoid receptor 2 agonist
has_related_synonym: cannabinoid receptor 2 agonists
has_related_synonym: cannabinoid receptor type 2 agonist
has_related_synonym: cannabinoid receptor type 2 agonists
has_related_synonym: type 2 cannabinoid receptor agonist
has_related_synonym: type 2 cannabinoid receptor agonists
id: CHEBI:146246
in subset: 3 STAR

oneirogen
type: Class
subclass of: psychotropic drug
textual definition: Any substance that produces or enhances dream-like states of consciousness.
imported from: chebi.owl
has cross-reference: Wikipedia:Oneirogen
has_obo_namespace: chebi_ontology
has_related_synonym: oneirogens
id: CHEBI:146270
in subset: 3 STAR

EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
type: Class
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69).
imported from: chebi.owl
has cross-reference: Wikipedia:C30_Endopeptidase
has_obo_namespace: chebi_ontology
has_related_synonym: 3C-like protease inhibitor
has_related_synonym: 3C-like protease inhibitors
has_related_synonym: 3cLpro inhibitor
has_related_synonym: 3cLpro inhibitors
has_related_synonym: EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitors
has_related_synonym: EC 3.4.22.69 inhibitor
has_related_synonym: EC 3.4.22.69 inhibitors
has_related_synonym: Mpro inhibitor
has_related_synonym: Mpro inhibitors
has_related_synonym: SARS 3C-like protease inhibitor
has_related_synonym: SARS 3C-like protease inhibitors
has_related_synonym: SARS coronavirus 3CL protease inhibitor
has_related_synonym: SARS coronavirus 3CL protease inhibitors
has_related_synonym: SARS coronavirus main peptidase inhibitor
has_related_synonym: SARS coronavirus main peptidase inhibitors
has_related_synonym: SARS coronavirus main protease inhibitor
has_related_synonym: SARS coronavirus main protease inhibitors
has_related_synonym: SARS coronavirus main proteinase inhibitor
has_related_synonym: SARS coronavirus main proteinase inhibitors
has_related_synonym: SARS-CoV 3CLpro enzyme inhibitor
has_related_synonym: SARS-CoV 3CLpro enzyme inhibitors
has_related_synonym: SARS-CoV Mpro inhibitor
has_related_synonym: SARS-CoV Mpro inhibitors
has_related_synonym: SARS-CoV main protease inhibitor
has_related_synonym: SARS-CoV main protease inhibitors
has_related_synonym: coronavirus 3C-like protease inhibitor
has_related_synonym: coronavirus 3C-like protease inhibitors
has_related_synonym: severe acute respiratory syndrome coronavirus main protease inhibitor
has_related_synonym: severe acute respiratory syndrome coronavirus main protease inhibitors
id: CHEBI:147285
in subset: 3 STAR

EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor
type: Class
subclass of: EC 3.4.17* (metallocarboxypeptidase) inhibitor
textual definition: Any EC 3.4.17.* (metallocarboxypeptidase) inhibitor that inhibits the action of angiotensin-converting enzyme 2 (EC 3.4.17.23).
imported from: chebi.owl
has cross-reference: Wikipedia:Angiotensin-converting_enzyme_2
alternative_term: EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: ACE-2 inhibitor
has_related_synonym: ACE-2 inhibitors
has_related_synonym: ACE2 inhibitor
has_related_synonym: ACE2 inhibitors
has_related_synonym: EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitors
has_related_synonym: EC 3.4.17.23 inhibitor
has_related_synonym: EC 3.4.17.23 inhibitors
has_related_synonym: angiotensin converting enzyme 2 inhibitor
has_related_synonym: angiotensin converting enzyme 2 inhibitors
has_related_synonym: angiotensin converting enzyme-2 inhibitor
has_related_synonym: angiotensin converting enzyme-2 inhibitors
has_related_synonym: angiotensin-converting enzyme 2 inhibitor
has_related_synonym: angiotensin-converting enzyme 2 inhibitors
has_related_synonym: hACE2 inhibitor
has_related_synonym: hACE2 inhibitors
id: CHEBI:147289
in subset: 3 STAR

EC 3.4.17* (metallocarboxypeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the action of a metallocarboxypeptidase (EC 3.4.17.*).
imported from: chebi.owl
alternative_term: EC 3.4.17* (metallocarboxypeptidase) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.17* (metallocarboxypeptidase) inhibitors
has_related_synonym: EC 3.4.17.* inhibitor
has_related_synonym: EC 3.4.17.* inhibitors
has_related_synonym: metallocarboxypeptidase inhibitor
has_related_synonym: metallocarboxypeptidase inhibitors
id: CHEBI:147290
in subset: 3 STAR

nitrification inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor added to nitrogen fertilizers which can reduce the rate at which ammonium is converted to nitrate. Under appropriate conditions, this can help reduce nitrogen losses through denitrification and leaching.
imported from: chebi.owl
has cross-reference: Wikipedia:Nitrification
has_obo_namespace: chebi_ontology
has_related_synonym: nitrification inhibitors
id: CHEBI:148436
in subset: 3 STAR

spin trapping reagent
type: Class
subclass of: reagent
textual definition: A reagent used in electron paramagnetic resonance (EPR) spectroscopy to react covalently with radical products whose half-life is be too short to detect. The resulting adducts are more stable enabling their paramagnetic resonance spectra to be obtained.
imported from: chebi.owl
has cross-reference: Wikipedia:Spin_trapping
has_obo_namespace: chebi_ontology
has_related_synonym: spin trap
has_related_synonym: spin trapping reagents
has_related_synonym: spin traps
id: CHEBI:149497
in subset: 3 STAR

emetic
type: Class
subclass of: drug
textual definition: Any agent that induces nausea and vomiting.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: emetics
id: CHEBI:149552
in subset: 3 STAR

anticoronaviral agent
type: Class
subclass of: antiviral agent
textual definition: Any antiviral agent which inhibits the activity of coronaviruses.
imported from: chebi.owl
has cross-reference: Wikipedia:Coronavirus
alternative_term: anticoronaviral agent
has_obo_namespace: chebi_ontology
has_related_synonym: anti-coronaviral agent
has_related_synonym: anti-coronaviral agents
has_related_synonym: anti-coronavirus agent
has_related_synonym: anti-coronavirus agents
has_related_synonym: anticoronaviral agents
has_related_synonym: anticoronaviral drug
has_related_synonym: anticoronaviral drugs
has_related_synonym: anticoronavirus agent
has_related_synonym: anticoronavirus agents
has_related_synonym: anticoronviral agent
has_related_synonym: anticoronviral agents
id: CHEBI:149553
in subset: 3 STAR

EC 2.3.3.8 (ATP citrate synthase) inhibitor
type: Class
subclass of: EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor
textual definition: An EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor that interferes with the action of ATP citrate synthase (EC 2.3.3.8).
imported from: chebi.owl
has cross-reference: Wikipedia:ATP_citrate_synthase
alternative_term: EC 2.3.3.8 (ATP citrate synthase) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: ATP citrate (pro-S)-lyase inhibitor
has_related_synonym: ATP citrate (pro-S)-lyase inhibitors
has_related_synonym: ATP citrate lyase inhibitor
has_related_synonym: ATP citrate lyase inhibitors
has_related_synonym: ATP citrate synthase inhibitor
has_related_synonym: ATP citrate synthase inhibitors
has_related_synonym: ATP-citric lyase inhibitor
has_related_synonym: ATP-citric lyase inhibitors
has_related_synonym: ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO(-)->acetyl-CoA] (ATP-dephosphorylating) inhibitor
has_related_synonym: ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO(-)->acetyl-CoA] (ATP-dephosphorylating) inhibitors
has_related_synonym: EC 2.3.3.8 (ATP citrate synthase) inhibitors
has_related_synonym: EC 2.3.3.8 inhibitor
has_related_synonym: EC 2.3.3.8 inhibitors
has_related_synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing, ADP-phosphorylating) inhibitor
has_related_synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing, ADP-phosphorylating) inhibitors
has_related_synonym: adenosine triphosphate citrate lyase inhibitor
has_related_synonym: adenosine triphosphate citrate lyase inhibitors
has_related_synonym: citrate cleavage enzyme inhibitor
has_related_synonym: citrate cleavage enzyme inhibitors
has_related_synonym: citrate-ATP lyase inhibitor
has_related_synonym: citrate-ATP lyase inhibitors
has_related_synonym: citric cleavage enzyme inhibitor
has_related_synonym: citric cleavage enzyme inhibitors
id: CHEBI:149598
in subset: 3 STAR

EC 3.4.21.36 (pancreatic elastase) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the activity of pancreatic elastase (EC 3.4.21.36).
imported from: chebi.owl
has cross-reference: Wikipedia:Pancreatic_elastase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.36 (pancreatic elastase) inhibitors
has_related_synonym: EC 3.4.21.36 inhibitor
has_related_synonym: EC 3.4.21.36 inhibitors
has_related_synonym: elastase inhibitor
has_related_synonym: elastase inhibitors
has_related_synonym: elaszym inhibitor
has_related_synonym: elaszym inhibitors
has_related_synonym: pancreatic elastase (EC 3.4.21.36) inhibitor
has_related_synonym: pancreatic elastase (EC 3.4.21.36) inhibitors
has_related_synonym: pancreatic elastase I inhibitor
has_related_synonym: pancreatic elastase I inhibitors
has_related_synonym: pancreatic elastase inhibitor
has_related_synonym: pancreatic elastase inhibitors
has_related_synonym: pancreatopeptidase E inhibitor
has_related_synonym: pancreatopeptidase E inhibitors
has_related_synonym: serine elastase inhibitor
has_related_synonym: serine elastase inhibitors
id: CHEBI:149639
in subset: 3 STAR

chemokine receptor 2 antagonist
type: Class
subclass of: antagonist
textual definition: An antogonist that blocks chemokine receptor 2 (CCR2).
imported from: chebi.owl
has cross-reference: Wikipedia:CCR2
has_obo_namespace: chebi_ontology
has_related_synonym: C-C chemokine receptor type 2 antagonist
has_related_synonym: C-C chemokine receptor type 2 antagonists
has_related_synonym: CCR-2 antagonist
has_related_synonym: CCR-2 antagonists
has_related_synonym: CCR2 antagonist
has_related_synonym: CCR2 antagonists
has_related_synonym: CD192 antagonist
has_related_synonym: CD192 antagonists
has_related_synonym: CKR-2B antagonist
has_related_synonym: CKR-2B antagonists
has_related_synonym: chemokine receptor 2 antagonists
id: CHEBI:149711
in subset: 3 STAR

SERCA activator
type: Class
subclass of: enzyme activator
textual definition: Any compound that activates Sarcoplasmic/Endoplasmic Reticulum Calcium-ATPase (EC 7.2.2.10).
imported from: chebi.owl
has cross-reference: Wikipedia:SERCA
has_obo_namespace: chebi_ontology
has_related_synonym: EC 7.2.2.10 activator
has_related_synonym: EC 7.2.2.10 activators
has_related_synonym: SERCA activators
has_related_synonym: Sarcoplasmic/Endoplasmic Reticulum Calcium-ATPase activator
has_related_synonym: Sarcoplasmic/Endoplasmic Reticulum Calcium-ATPase activators
id: CHEBI:150006
in subset: 3 STAR

electron donor
type: Class
subclass of: donor
textual definition: A molecular entity that can transfer an electron to another molecular entity.
imported from: chebi.owl
alternative_term: electron donor
has_obo_namespace: chebi_ontology
has_related_synonym: Elektronendonator
has_related_synonym: donneur d'electron
id: CHEBI:15022
in subset: 3 STAR

acceptor
type: Class
subclass of: chemical role
textual definition: A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity.
imported from: chebi.owl
has_alternative_id: CHEBI:13699
has_alternative_id: CHEBI:2377
has cross-reference: KEGG:C00028
has cross-reference: KEGG:C16722
alternative_term: Acceptor
has_obo_namespace: chebi_ontology
has_related_synonym: A
has_related_synonym: Akzeptor
has_related_synonym: Hydrogen-acceptor
has_related_synonym: Oxidized donor
has_related_synonym: accepteur
id: CHEBI:15339
in subset: 3 STAR

topoisomerase II inhibitor
type: Class
subclass of: topoisomerase inhibitor
textual definition: A topoisomerase inhibitor that inhibits DNA topoisomerase II.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: topoisomerase II inhibitors
id: CHEBI:156203
in subset: 3 STAR

MAIT cell agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates mucosal associated invariant T cells (MAIT cells).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: MAIT cell agonists
has_related_synonym: mucosal associated invariant T cell agonist
has_related_synonym: mucosal associated invariant T cell agonists
id: CHEBI:156211
in subset: 3 STAR

EC 3.4.21.75 (furin) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of furin (EC 3.4.21.75).
imported from: chebi.owl
has cross-reference: Wikipedia:Furin
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.75 (furin) inhibitors
has_related_synonym: EC 3.4.21.75 inhibitor
has_related_synonym: EC 3.4.21.75 inhibitors
has_related_synonym: PACE inhibitor
has_related_synonym: PACE inhibitors
has_related_synonym: PC1 inhibitor
has_related_synonym: PC1 inhibitors
has_related_synonym: SPC3 inhibitor
has_related_synonym: SPC3 inhibitors
has_related_synonym: dibasic processing enzyme inhibitor
has_related_synonym: dibasic processing enzyme inhibitors
has_related_synonym: furin convertase inhibitor
has_related_synonym: furin convertase inhibitors
has_related_synonym: furin inhibitor
has_related_synonym: furin inhibitors
has_related_synonym: paired basic amino acid cleaving enzyme inhibitor
has_related_synonym: paired basic amino acid cleaving enzyme inhibitors
has_related_synonym: paired basic amino acid converting enzyme inhibitor
has_related_synonym: paired basic amino acid converting enzyme inhibitors
has_related_synonym: prohormone convertase inhibitor
has_related_synonym: prohormone convertase inhibitors
has_related_synonym: proprotein convertase inhibitor
has_related_synonym: proprotein convertase inhibitors
has_related_synonym: serine proteinase PACE inhibitor
has_related_synonym: serine proteinase PACE inhibitors
id: CHEBI:156297
in subset: 3 STAR

EC 2.4.1.109 (dolichyl-phosphate-mannose-protein mannosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of dolichyl-phosphate-mannose-protein mannosyltransferase (EC 2.4.1.109).
imported from: chebi.owl
has cross-reference: Wikipedia:Dolichyl-phosphate-mannose-protein_mannosyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.109 (dolichyl-phosphate-mannose-protein mannosyltransferase) inhibitors
has_related_synonym: EC 2.4.1.109 inhibitor
has_related_synonym: EC 2.4.1.109 inhibitors
has_related_synonym: PMT inhibitor
has_related_synonym: PMT inhibitors
has_related_synonym: dolichol phosphomannose-protein mannosyltransferase inhibitor
has_related_synonym: dolichol phosphomannose-protein mannosyltransferase inhibitors
has_related_synonym: dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase inhibitor
has_related_synonym: dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase inhibitors
has_related_synonym: dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase inhibitor
has_related_synonym: dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase inhibitors
has_related_synonym: dolichyl-phosphate-mannose--protein mannosyltransferase inhibitor
has_related_synonym: dolichyl-phosphate-mannose--protein mannosyltransferase inhibitors
has_related_synonym: protein O-D-mannosyltransferase inhibitor
has_related_synonym: protein O-D-mannosyltransferase inhibitors
id: CHEBI:156527
in subset: 3 STAR

Furafylline
type: Class
subclass of: molecular entity
imported from: chebi.owl
charge: 0
formula: C12H12N4O3
inchi: InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14)
inchikey: KGQZGCIVHYLPBH-UHFFFAOYSA-N
mass: 260.253
monoisotopicmass: 260.09094
smiles: O1C(CN2C=3N=C(NC3C(=O)N(C2=O)C)C)=CC=C1
has cross-reference: CAS:80288-49-9
has cross-reference: Chemspider:3315
alternative_term: 3-(uran-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione
has_obo_namespace: chebi_ontology
id: CHEBI:165840
in subset: 2 STAR

carbohydrate
type: Class
subclass of: molecular entity
textual definition: Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.
imported from: chebi.owl
has_alternative_id: CHEBI:15131
has_alternative_id: CHEBI:23008
has_alternative_id: CHEBI:9318
has cross-reference: Wikipedia:Carbohydrate
alternative_term: carbohydrate
alternative_term: carbohydrates
has_obo_namespace: chebi_ontology
has_related_synonym: Kohlenhydrat
has_related_synonym: Kohlenhydrate
has_related_synonym: a carbohydrate
has_related_synonym: carbohidrato
has_related_synonym: carbohidratos
has_related_synonym: glucide
has_related_synonym: glucides
has_related_synonym: glucido
has_related_synonym: glucidos
has_related_synonym: hydrates de carbone
has_related_synonym: saccharide
has_related_synonym: saccharides
has_related_synonym: saccharidum
id: CHEBI:16646
in subset: 3 STAR

EC 3.4.23.15 (renin) inhibitor
type: Class
subclass of: EC 3.4.23.* (aspartic endopeptidase) inhibitor
textual definition: An EC 3.4.23.* (aspartic endopeptidase) inhibitor that interferes with the activity of renin (EC 3.4.23.15).
imported from: chebi.owl
has cross-reference: Wikipedia:Renin
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.23.15 (renin) inhibitors
has_related_synonym: EC 3.4.23.15 inhibitor
has_related_synonym: EC 3.4.23.15 inhibitors
has_related_synonym: angiotensin-forming enzyme inhibitor
has_related_synonym: angiotensin-forming enzyme inhibitors
has_related_synonym: angiotensinogenase inhibitor
has_related_synonym: angiotensinogenase inhibitors
has_related_synonym: renin inhibitor
has_related_synonym: renin inhibitors
id: CHEBI:166822
in subset: 3 STAR

copper chelator
type: Class
subclass of: chelator
textual definition: A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points.
imported from: chebi.owl
has cross-reference: PMID:24934357
has cross-reference: PMID:29710396
alternative_term: copper chelator
has_obo_namespace: chebi_ontology
has_related_synonym: copper chelate
has_related_synonym: copper chelating agent
has_related_synonym: copper chelating agents
has_related_synonym: copper chelators
id: CHEBI:166831
in subset: 3 STAR

neuropilin receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates neuropilin receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Neuropilin
has_obo_namespace: chebi_ontology
has_related_synonym: NRP antagonist
has_related_synonym: NRP antagonists
has_related_synonym: neuropilin receptor antagonists
id: CHEBI:166909
in subset: 3 STAR

kappa-opioid receptor antagonist
type: Class
subclass of: kappa-opioid agent
subclass of: opioid receptor antagonist
textual definition: Any compound that exhibits antagonist activity at the kappa-opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: kappa-opioid antagonist
has_related_synonym: kappa-opioid antagonists
has_related_synonym: kappa-opioid receptor antagonists
id: CHEBI:167165
in subset: 3 STAR

piscicide
type: Class
subclass of: pesticide
textual definition: A substance which is poisonous to fish and is primarily used to eliminate dominant species of fish in water.
imported from: chebi.owl
has cross-reference: Wikipedia:Piscicide
has_obo_namespace: chebi_ontology
has_related_synonym: piscicides
id: CHEBI:167183
in subset: 3 STAR

ovicide
type: Class
subclass of: insecticide
textual definition: Any insecticide that is capable of killing egg cells.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ovicides
id: CHEBI:167523
in subset: 3 STAR

CPSF3 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor which inhibits the activity of cleavage and polyadenylation specificity factor subunit 3 protein (CPSF3).
imported from: chebi.owl
has cross-reference: Wikipedia:CPSF3
has_obo_namespace: chebi_ontology
has_related_synonym: CPSF-73 inhibitor
has_related_synonym: CPSF-73 inhibitors
has_related_synonym: CPSF3 inhibitors
has_related_synonym: CPSF73 inhibitor
has_related_synonym: CPSF73 inhibitors
has_related_synonym: cleavage and polyadenylation specific factor 3 inhibitor
has_related_synonym: cleavage and polyadenylation specific factor 3 inhibitors
has_related_synonym: cleavage and polyadenylation specificity factor 73 KDa subunit inhibitor
has_related_synonym: cleavage and polyadenylation specificity factor 73 KDa subunit inhibitors
has_related_synonym: cleavage and polyadenylation specificity factor subunit 3 inhibitor
has_related_synonym: cleavage and polyadenylation specificity factor subunit 3 inhibitors
id: CHEBI:167633
in subset: 3 STAR

EC 6.1.1.6 (lysine--tRNA ligase) inhibitor
type: Class
subclass of: EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor
textual definition: An EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor that specifically inhibits the action of lysine-tRNA ligase (EC 6.1.1.6).
imported from: chebi.owl
has cross-reference: Wikipedia:Lysine-tRNA_ligase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.1.1.6 (lysine--tRNA ligase) inhibitors
has_related_synonym: EC 6.1.1.6 inhibitor
has_related_synonym: EC 6.1.1.6 inhibitors
has_related_synonym: L-lysine-transfer RNA ligase inhibitor
has_related_synonym: L-lysine-transfer RNA ligase inhibitors
has_related_synonym: L-lysine:tRNA(Lys) ligase (AMP-forming) inhibitor
has_related_synonym: L-lysine:tRNA(Lys) ligase (AMP-forming) inhibitors
has_related_synonym: LysRS inhibitor
has_related_synonym: LysRS inhibitors
has_related_synonym: lysine translase inhibitor
has_related_synonym: lysine translase inhibitors
has_related_synonym: lysine--tRNA ligase inhibitor
has_related_synonym: lysine--tRNA ligase inhibitors
has_related_synonym: lysine-tRNA synthetase inhibitor
has_related_synonym: lysine-tRNA synthetase inhibitors
has_related_synonym: lysyl-tRNA synthetase inhibitor
has_related_synonym: lysyl-tRNA synthetase inhibitors
has_related_synonym: lysyl-transfer RNA synthetase inhibitor
has_related_synonym: lysyl-transfer RNA synthetase inhibitors
has_related_synonym: lysyl-transfer ribonucleate synthetase inhibitor
has_related_synonym: lysyl-transfer ribonucleate synthetase inhibitors
id: CHEBI:167677
in subset: 3 STAR

EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of Enhancer of zeste homolog 2 (EZH2), a histone-lysine N-methyltransferase (EC 2.1.1.43).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitors
has_related_synonym: EZH2 inhibitor
has_related_synonym: EZH2 inhibitors
id: CHEBI:167694
in subset: 3 STAR

necroptosis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any substance that inhibits the process of necroptosis (programmed form of necrosis) in organisms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: necroptosis inhibitors
id: CHEBI:167704
in subset: 3 STAR

EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
type: Class
subclass of: DNA polymerase inhibitor
textual definition: A DNA polymerase inhibitor that interferes with the action of a RNA-directed RNA polymerase (EC 2.7.7.48).
imported from: chebi.owl
has cross-reference: Wikipedia:RNA-dependent_RNA_polymerase
has_obo_namespace: chebi_ontology
has_related_synonym: 3D polymerase inhibitor
has_related_synonym: 3D polymerase inhibitors
has_related_synonym: EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitors
has_related_synonym: EC 2.7.7.48 inhibitor
has_related_synonym: EC 2.7.7.48 inhibitors
has_related_synonym: PB1 proteins inhibitor
has_related_synonym: PB1 proteins inhibitors
has_related_synonym: PB2 proteins inhibitor
has_related_synonym: PB2 proteins inhibitors
has_related_synonym: Q-beta replicase inhibitor
has_related_synonym: Q-beta replicase inhibitors
has_related_synonym: RDRP inhibitor
has_related_synonym: RDRP inhibitors
has_related_synonym: RNA nucleotidyltransferase (RNA-directed) inhibitor
has_related_synonym: RNA nucleotidyltransferase (RNA-directed) inhibitors
has_related_synonym: RNA replicase inhibitor
has_related_synonym: RNA replicase inhibitors
has_related_synonym: RNA synthetase inhibitor
has_related_synonym: RNA synthetase inhibitors
has_related_synonym: RNA transcriptase inhibitor
has_related_synonym: RNA transcriptase inhibitors
has_related_synonym: RNA-dependent RNA polymerase inhibitor
has_related_synonym: RNA-dependent RNA polymerase inhibitors
has_related_synonym: RNA-dependent RNA replicase inhibitor
has_related_synonym: RNA-dependent RNA replicase inhibitors
has_related_synonym: RNA-dependent ribonucleate nucleotidyltransferase inhibitor
has_related_synonym: RNA-dependent ribonucleate nucleotidyltransferase inhibitors
has_related_synonym: RNA-directed RNA polymerase inhibitor
has_related_synonym: RNA-directed RNA polymerase inhibitors
has_related_synonym: phage f2 replicase inhibitor
has_related_synonym: phage f2 replicase inhibitors
has_related_synonym: polymerase L inhibitor
has_related_synonym: polymerase L inhibitors
has_related_synonym: ribonucleic acid replicas inhibitor
has_related_synonym: ribonucleic acid replicas inhibitors
has_related_synonym: ribonucleic acid-dependent ribonucleate nucleotidyltransferase inhibitor
has_related_synonym: ribonucleic acid-dependent ribonucleate nucleotidyltransferase inhibitors
has_related_synonym: ribonucleic acid-dependent ribonucleic acid polymeras inhibitor
has_related_synonym: ribonucleic acid-dependent ribonucleic acid polymeras inhibitors
has_related_synonym: ribonucleic replicase inhibitor
has_related_synonym: ribonucleic replicase inhibitors
has_related_synonym: ribonucleic synthetase inhibitor
has_related_synonym: ribonucleic synthetase inhibitors
id: CHEBI:170010
in subset: 3 STAR

antiamoebic agent
type: Class
subclass of: antiparasitic agent
textual definition: An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: amebicide
has_related_synonym: amebicides
has_related_synonym: amoebicide
has_related_synonym: amoebicides
has_related_synonym: anti-amoebic agent
has_related_synonym: anti-amoebic agents
has_related_synonym: anti-amoebic drug
has_related_synonym: anti-amoebic drugs
has_related_synonym: antiamoebic
has_related_synonym: antiamoebic agents
has_related_synonym: antiamoebic drug
has_related_synonym: antiamoebic drugs
has_related_synonym: antiamoebics
id: CHEBI:171664
in subset: 3 STAR

EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of mRNA m6A methyltransferase (EC 2.1.1.348).
imported from: chebi.owl
has cross-reference: Wikipedia:METTL3
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.348 inhibitor
has_related_synonym: EC 2.1.1.348 inhibitors
has_related_synonym: METTL14 inhibitor
has_related_synonym: METTL14 inhibitors
has_related_synonym: METTL3 inhibitor
has_related_synonym: METTL3 inhibitors
id: CHEBI:172326
in subset: 3 STAR

EC 2.6.1.11 (acetylornithine transaminase) inhibitor
type: Class
subclass of: EC 2.6.1.* (transaminase) inhibitor
textual definition: An EC 2.6.1.* (transaminase) inhibitor that interferes with the action of acetylornithine transaminase (EC 2.6.1.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Acetylornithine_transaminase
has_obo_namespace: chebi_ontology
has_related_synonym: 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase inhibitor
has_related_synonym: 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase inhibitors
has_related_synonym: ACOAT inhibitor
has_related_synonym: ACOAT inhibitors
has_related_synonym: EC 2.6.1.11 (acetylornithine transaminase) inhibitors
has_related_synonym: EC 2.6.1.11 inhibitor
has_related_synonym: EC 2.6.1.11 inhibitors
has_related_synonym: N(2)-acetyl-L-ornithine:2-oxoglutarate aminotransferase inhibitor
has_related_synonym: N(2)-acetyl-L-ornithine:2-oxoglutarate aminotransferase inhibitors
has_related_synonym: N(2)-acetylornithine 5-transaminase inhibitor
has_related_synonym: N(2)-acetylornithine 5-transaminase inhibitors
has_related_synonym: N-acetylornithine aminotransferase inhibitor
has_related_synonym: N-acetylornithine aminotransferase inhibitors
has_related_synonym: N-acetylornithine-delta-transaminase inhibitor
has_related_synonym: N-acetylornithine-delta-transaminase inhibitors
has_related_synonym: acetylornithine 5-aminotransferase inhibitor
has_related_synonym: acetylornithine 5-aminotransferase inhibitors
has_related_synonym: acetylornithine aminotransferase inhibitor
has_related_synonym: acetylornithine aminotransferase inhibitors
has_related_synonym: acetylornithine delta-transaminase inhibitor
has_related_synonym: acetylornithine delta-transaminase inhibitors
has_related_synonym: acetylornithine transaminase inhibitor
has_related_synonym: acetylornithine transaminase inhibitors
has_related_synonym: succinylornithine aminotransferase inhibitor
has_related_synonym: succinylornithine aminotransferase inhibitors
id: CHEBI:172919
in subset: 3 STAR

antimicrobial cosmetic preservative
type: Class
subclass of: antimicrobial agent
textual definition: An antimicrobial agent that is added to cosmetic formulations to maintain the microbiological safety of the products by inhibiting the growth of fungi or bacteria.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antimicrobial cosmetic preservatives
id: CHEBI:172949
in subset: 3 STAR

ferroptosis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
imported from: chebi.owl
has cross-reference: PMID:32015325
has cross-reference: PMID:32256352
has cross-reference: PMID:32413317
has cross-reference: PMID:33495651
has cross-reference: Wikipedia:Ferroptosis
has_obo_namespace: chebi_ontology
has_related_synonym: ferroptosis inhibitors
id: CHEBI:173084
in subset: 3 STAR

ferroptosis inducer
type: Class
subclass of: biochemical role
textual definition: Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
imported from: chebi.owl
has cross-reference: PMID:31899616
has cross-reference: PMID:32015325
has cross-reference: PMID:33167414
has cross-reference: PMID:34012798
has cross-reference: Wikipedia:Ferroptosis
has_obo_namespace: chebi_ontology
has_related_synonym: ferroptosis inducers
id: CHEBI:173085
in subset: 3 STAR

EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor
type: Class
subclass of: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
textual definition: An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of inositol-phosphate phosphatase (EC 3.1.3.25).
imported from: chebi.owl
has cross-reference: Wikipedia:Inositol-phosphate_phosphatase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitors
has_related_synonym: EC 3.1.3.25 inhibitor
has_related_synonym: EC 3.1.3.25 inhibitors
has_related_synonym: IMPase inhibitor
has_related_synonym: IMPase inhibitors
has_related_synonym: L-myo-inositol-1-phosphate phosphatase inhibitor
has_related_synonym: L-myo-inositol-1-phosphate phosphatase inhibitors
has_related_synonym: inositol 1-phosphatase inhibitor
has_related_synonym: inositol 1-phosphatase inhibitors
has_related_synonym: inositol monophosphatase inhibitor
has_related_synonym: inositol monophosphatase inhibitors
has_related_synonym: inositol monophosphate phosphatase inhibitor
has_related_synonym: inositol monophosphate phosphatase inhibitors
has_related_synonym: inositol phosphatase inhibitor
has_related_synonym: inositol phosphatase inhibitors
has_related_synonym: inositol phosphate phosphatase inhibitor
has_related_synonym: inositol phosphate phosphatase inhibitors
has_related_synonym: inositol-1(or 4)-monophosphatase inhibitor
has_related_synonym: inositol-1(or 4)-monophosphatase inhibitors
has_related_synonym: inositol-phosphate phosphatase inhibitor
has_related_synonym: inositol-phosphate phosphatase inhibitors
has_related_synonym: myo-inositol 1-phosphatase inhibitor
has_related_synonym: myo-inositol 1-phosphatase inhibitors
has_related_synonym: myo-inositol monophosphatase inhibitor
has_related_synonym: myo-inositol monophosphatase inhibitors
has_related_synonym: myo-inositol-1(or 4)-monophosphatase inhibitor
has_related_synonym: myo-inositol-1(or 4)-monophosphatase inhibitors
has_related_synonym: myo-inositol-1(or 4)-phosphate phosphohydrolase inhibitor
has_related_synonym: myo-inositol-1(or 4)-phosphate phosphohydrolase inhibitors
has_related_synonym: myo-inositol-1-phosphatase inhibitor
has_related_synonym: myo-inositol-1-phosphatase inhibitors
id: CHEBI:173094
in subset: 3 STAR

voltage-dependent anion channel inhibitor
type: Class
subclass of: ion transport inhibitor
textual definition: Any agent that inhibits voltage-dependent anion channels.
imported from: chebi.owl
has cross-reference: Wikipedia:Voltage-dependent_anion_channel
has_obo_namespace: chebi_ontology
has_related_synonym: VDAC blocker
has_related_synonym: VDAC blockers
has_related_synonym: VDAC inhibitor
has_related_synonym: VDAC inhibitors
has_related_synonym: voltage-dependent anion channel blocker
has_related_synonym: voltage-dependent anion channel blockers
has_related_synonym: voltage-dependent anion channel inhibitors
has_related_synonym: voltage-dependent anion-selective channel blocker
has_related_synonym: voltage-dependent anion-selective channel blockers
has_related_synonym: voltage-dependent anion-selective channel inhibitor
has_related_synonym: voltage-dependent anion-selective channel inhibitors
id: CHEBI:173100
in subset: 3 STAR

thioredoxin inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any substance which inhibits thioredoxin, a group of small redox proteins.
imported from: chebi.owl
has cross-reference: Wikipedia:Thioredoxin
has_obo_namespace: chebi_ontology
has_related_synonym: TRX inhibitor
has_related_synonym: TRX inhibitors
has_related_synonym: TRX1 inhibitor
has_related_synonym: TRX1 inhibitors
has_related_synonym: TXN inhibitor
has_related_synonym: TXN inhibitors
has_related_synonym: thioredoxin inhibitors
id: CHEBI:173108
in subset: 3 STAR

testosterone
type: Class
subclass of: molecular entity
textual definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
imported from: chebi.owl
charge: 0
formula: C19H28O2
inchi: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
inchikey: MUMGGOZAMZWBJJ-DYKIIFRCSA-N
mass: 288.42440
monoisotopicmass: 288.20893
has_alternative_id: CHEBI:15214
has_alternative_id: CHEBI:26883
has_alternative_id: CHEBI:45798
has_alternative_id: CHEBI:9461
has cross-reference: Beilstein:3653705
has cross-reference: CAS:58-22-0
has cross-reference: DrugBank:DB00624
has cross-reference: Drug_Central:2607
has cross-reference: Gmelin:538843
has cross-reference: HMDB:HMDB0000234
has cross-reference: KEGG:C00535
has cross-reference: KEGG:D00075
has cross-reference: KNApSAcK:C00003675
has cross-reference: LIPID_MAPS_instance:LMST02020002
has cross-reference: PDBeChem:TES
has cross-reference: PMID:10438974
has cross-reference: PMID:11786693
has cross-reference: PMID:18900503
has cross-reference: PMID:24498482
has cross-reference: Reaxys:1915399
has cross-reference: Wikipedia:Testosterone
alternative_term: 17beta-hydroxyandrost-4-en-3-one
alternative_term: TESTOSTERONE
alternative_term: Testosterone
alternative_term: testosterone
has_obo_namespace: chebi_ontology
has_related_synonym: 17beta-Hydroxy-4-androsten-3-one
has_related_synonym: 17beta-hydroxy-4-androsten-3-one
has_related_synonym: 4-androsten-17beta-ol-3-one
has_related_synonym: Androderm
has_related_synonym: Testosteron
has_related_synonym: testosterona
has_related_synonym: testosterone
has_related_synonym: testosteronum
id: CHEBI:17347
in subset: 3 STAR

EC 1.11.1.9 (glutathione peroxidase) inhibitor
type: Class
subclass of: EC 1.11.1.* (peroxidases) inhibitor
textual definition: An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of glutathione peroxidase (EC 1.11.1.9).
imported from: chebi.owl
has cross-reference: Wikipedia:Glutathione_peroxidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.11.1.9 (glutathione peroxidase) inhibitors
has_related_synonym: EC 1.11.1.9 inhibitor
has_related_synonym: EC 1.11.1.9 inhibitors
has_related_synonym: GSH peroxidase inhibitor
has_related_synonym: GSH peroxidase inhibitors
has_related_synonym: glutathione peroxidase inhibitor
has_related_synonym: glutathione peroxidase inhibitors
has_related_synonym: reduced glutathione peroxidase inhibitor
has_related_synonym: reduced glutathione peroxidase inhibitors
has_related_synonym: selenium-glutathione peroxidase inhibitor
has_related_synonym: selenium-glutathione peroxidase inhibitors
id: CHEBI:176342
in subset: 3 STAR

actin polymerisation inducer
type: Class
subclass of: biochemical role
textual definition: Any substance that induces the polymerisation of the protein actin.
imported from: chebi.owl
has cross-reference: PMID:33066873
has_obo_namespace: chebi_ontology
has_related_synonym: actin polymerisation enhancer
has_related_synonym: actin polymerisation enhancers
has_related_synonym: actin polymerisation inducers
has_related_synonym: inducer of actin polymerization
has_related_synonym: inducers of actin polymerization
id: CHEBI:176495
in subset: 3 STAR

geroprotector
type: Class
subclass of: protective agent
textual definition: Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
imported from: chebi.owl
has cross-reference: PMID:23372317
has cross-reference: PMID:28580190
has cross-reference: PMID:30885572
has cross-reference: PMID:33144142
has cross-reference: PMID:33973253
has cross-reference: PMID:34606237
has cross-reference: Wikipedia:Geroprotector
has_obo_namespace: chebi_ontology
has_related_synonym: anti-aging agent
has_related_synonym: anti-aging agents
has_related_synonym: anti-aging drug
has_related_synonym: anti-aging drugs
has_related_synonym: geroprotective agent
has_related_synonym: geroprotective agents
has_related_synonym: geroprotectors
id: CHEBI:176497
in subset: 3 STAR

ferroptosis suppressor protein 1 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: An inhibitor which inhibits the action of ferroptosis suppressor protein 1.
imported from: chebi.owl
has cross-reference: Wikipedia:AIFM2
has_obo_namespace: chebi_ontology
has_related_synonym: AIFM2 inhibitor
has_related_synonym: AIFM2 inhibitors
has_related_synonym: FSP1 inhibitor
has_related_synonym: FSP1 inhibitors
has_related_synonym: apoptosis-inducing factor mitochondria-associated 2 inhibitor
has_related_synonym: apoptosis-inducing factor mitochondria-associated 2 inhibitors
has_related_synonym: ferroptosis suppressor protein 1 inhibitors
id: CHEBI:176508
in subset: 3 STAR

electron acceptor
type: Class
subclass of: acceptor
textual definition: A substance to which an electron may be transferred.
imported from: chebi.owl
has_alternative_id: CHEBI:14207
has_alternative_id: CHEBI:14716
has_alternative_id: CHEBI:7835
has cross-reference: KEGG:C02177
alternative_term: electron acceptor
has_obo_namespace: chebi_ontology
has_related_synonym: Elektronenakzeptor
has_related_synonym: Oxidized donor
id: CHEBI:17654
in subset: 3 STAR

EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of pyruvate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Pyruvate_dehydrogenase_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitors
has_related_synonym: EC 2.7.11.2 inhibitor
has_related_synonym: EC 2.7.11.2 inhibitors
has_related_synonym: PDH kinase inhibitor
has_related_synonym: PDH kinase inhibitors
has_related_synonym: PDHK inhibitor
has_related_synonym: PDHK inhibitors
has_related_synonym: PDK inhibitor
has_related_synonym: PDK inhibitors
has_related_synonym: PDK1 inhibitor
has_related_synonym: PDK1 inhibitors
has_related_synonym: PDK2 inhibitor
has_related_synonym: PDK2 inhibitors
has_related_synonym: PDK3 inhibitor
has_related_synonym: PDK3 inhibitors
has_related_synonym: PDK4 inhibitor
has_related_synonym: PDK4 inhibitors
has_related_synonym: STK1 inhibitor
has_related_synonym: STK1 inhibitors
has_related_synonym: [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor
has_related_synonym: [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitors
has_related_synonym: pyruvate dehydrogenase (acetyl-transferring) kinase inhibitor
has_related_synonym: pyruvate dehydrogenase (acetyl-transferring) kinase inhibitors
has_related_synonym: pyruvate dehydrogenase kinase (phosphorylating) inhibitor
has_related_synonym: pyruvate dehydrogenase kinase (phosphorylating) inhibitors
has_related_synonym: pyruvate dehydrogenase kinase activator protein inhibitor
has_related_synonym: pyruvate dehydrogenase kinase activator protein inhibitors
has_related_synonym: pyruvate dehydrogenase kinase inhibitor
has_related_synonym: pyruvate dehydrogenase kinase inhibitors
id: CHEBI:176961
in subset: 3 STAR

somatostatin receptor agonist
type: Class
subclass of: G-protein-coupled receptor agonist
textual definition: An agonist that binds to and activates somatostatin receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Somatostatin_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: SRIF agonist
has_related_synonym: SRIF agonists
has_related_synonym: SS-R agonist
has_related_synonym: SS-R agonists
has_related_synonym: SSR agonist
has_related_synonym: SSR agonists
has_related_synonym: SSTR agonist
has_related_synonym: SSTR agonists
has_related_synonym: somatostatin receptor agonists
id: CHEBI:177023
in subset: 3 STAR

donor
type: Class
subclass of: chemical role
textual definition: A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity.
imported from: chebi.owl
has_alternative_id: CHEBI:14202
has_alternative_id: CHEBI:4697
has cross-reference: KEGG:C01351
alternative_term: Donor
has_obo_namespace: chebi_ontology
has_related_synonym: Donator
has_related_synonym: donneur
id: CHEBI:17891
in subset: 3 STAR

(S)-Mephenytoin
type: Class
subclass of: molecular entity
imported from: chebi.owl
charge: 0
formula: C12H14N2O2
inchi: InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)/t12-/m0/s1
inchikey: GMHKMTDVRCWUDX-LBPRGKRZSA-N
mass: 218.256
monoisotopicmass: 218.10553
smiles: O=C1N(C(=O)N[C@@]1(CC)C2=CC=CC=C2)C
has cross-reference: CAS:70989-04-7
has cross-reference: Chemspider:97046
has cross-reference: KEGG:C20130
alternative_term: (5S)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
has_obo_namespace: chebi_ontology
id: CHEBI:179062
in subset: 2 STAR

neoantigen
type: Class
subclass of: antigen
textual definition: A mainly tumour-specific antigen generated by mutations in tumour cells. Neoantigens are only expressed in tumour cells.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: neoantigens
id: CHEBI:183050
in subset: 3 STAR

EC 3.2.1.52 (beta-N-acetylhexosaminidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of beta-N-acetylhexosaminidase (EC 3.2.1.52).
imported from: chebi.owl
has cross-reference: Wikipedia:Hexosaminidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.52 (beta-N-acetylhexosaminidase) inhibitors
has_related_synonym: EC 3.2.1.52 inhibitor
has_related_synonym: EC 3.2.1.52 inhibitors
has_related_synonym: N-acetyl-beta-D-hexosaminidase inhibitor
has_related_synonym: N-acetyl-beta-D-hexosaminidase inhibitors
has_related_synonym: N-acetyl-beta-hexosaminidase inhibitor
has_related_synonym: N-acetyl-beta-hexosaminidase inhibitors
has_related_synonym: N-acetylhexosaminidase inhibitor
has_related_synonym: N-acetylhexosaminidase inhibitors
has_related_synonym: beta-D-N-acetylhexosaminidase inhibitor
has_related_synonym: beta-D-N-acetylhexosaminidase inhibitors
has_related_synonym: beta-D-hexosaminidase inhibitor
has_related_synonym: beta-D-hexosaminidase inhibitors
has_related_synonym: beta-N-acetyl-D-hexosaminidase inhibitor
has_related_synonym: beta-N-acetyl-D-hexosaminidase inhibitors
has_related_synonym: beta-N-acetylglucosaminidase inhibitor
has_related_synonym: beta-N-acetylglucosaminidase inhibitors
has_related_synonym: beta-N-acetylhexosaminidase inhibitor
has_related_synonym: beta-N-acetylhexosaminidase inhibitors
has_related_synonym: beta-acetylaminodeoxyhexosidase inhibitor
has_related_synonym: beta-acetylaminodeoxyhexosidase inhibitors
has_related_synonym: beta-acetylhexosaminidinase inhibitor
has_related_synonym: beta-acetylhexosaminidinase inhibitors
has_related_synonym: beta-hexosaminidase inhibitor
has_related_synonym: beta-hexosaminidase inhibitors
has_related_synonym: hexosaminidase A inhibitor
has_related_synonym: hexosaminidase A inhibitors
has_related_synonym: hexosaminidase inhibitor
has_related_synonym: hexosaminidase inhibitors
id: CHEBI:184301
in subset: 3 STAR

EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
textual definition: Any EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of trans-cinnamate 4-monooxygenase (EC 1.14.14.91).
imported from: chebi.owl
has cross-reference: Wikipedia:Trans-cinnamate_4-monooxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: CA4H inhibitor
has_related_synonym: CA4H inhibitors
has_related_synonym: EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitors
has_related_synonym: EC 1.14.14.91 inhibitor
has_related_synonym: EC 1.14.14.91 inhibitors
has_related_synonym: cinnamate 4-hydroxylase inhibitor
has_related_synonym: cinnamate 4-hydroxylase inhibitors
has_related_synonym: cinnamate 4-monooxygenase inhibitor
has_related_synonym: cinnamate 4-monooxygenase inhibitors
has_related_synonym: cinnamate hydroxylase inhibitor
has_related_synonym: cinnamate hydroxylase inhibitors
has_related_synonym: cinnamic 4-hydroxylase inhibitor
has_related_synonym: cinnamic 4-hydroxylase inhibitors
has_related_synonym: cinnamic acid 4-hydroxylase inhibitor
has_related_synonym: cinnamic acid 4-hydroxylase inhibitors
has_related_synonym: cinnamic acid 4-monooxygenase inhibitor
has_related_synonym: cinnamic acid 4-monooxygenase inhibitors
has_related_synonym: cinnamic acid p-hydroxylase inhibitor
has_related_synonym: cinnamic acid p-hydroxylase inhibitors
has_related_synonym: cytochrome P450 cinnamate 4-hydroxylase inhibitor
has_related_synonym: cytochrome P450 cinnamate 4-hydroxylase inhibitors
has_related_synonym: t-cinnamic acid hydroxylase inhibitor
has_related_synonym: t-cinnamic acid hydroxylase inhibitors
has_related_synonym: trans-cinnamate 4-hydroxylase inhibitor
has_related_synonym: trans-cinnamate 4-hydroxylase inhibitors
has_related_synonym: trans-cinnamate 4-monooxygenase inhibitor
has_related_synonym: trans-cinnamate 4-monooxygenase inhibitors
has_related_synonym: trans-cinnamic acid 4-hydroxylase inhibitor
has_related_synonym: trans-cinnamic acid 4-hydroxylase inhibitors
id: CHEBI:184380
in subset: 3 STAR

urea herbicide
type: Class
subclass of: herbicide
textual definition: Any herbicide composed of urea or substituted urea substructure.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: substituted urea herbicide
has_related_synonym: substituted urea herbicides
has_related_synonym: urea herbicides
id: CHEBI:188147
in subset: 3 STAR

EC 3.4.21.61 (kexin) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of kexin (EC 3.4.21.61).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.61 (kexin) inhibitors
has_related_synonym: EC 3.4.21.61 inhibitor
has_related_synonym: EC 3.4.21.61 inhibitors
has_related_synonym: Kex 2p proteinase inhibitor
has_related_synonym: Kex 2p proteinase inhibitors
has_related_synonym: Kex2 endopeptidase inhibitor
has_related_synonym: Kex2 endopeptidase inhibitors
has_related_synonym: Kex2 endoprotease inhibitor
has_related_synonym: Kex2 endoprotease inhibitors
has_related_synonym: Kex2 endoproteinase inhibitor
has_related_synonym: Kex2 endoproteinase inhibitors
has_related_synonym: Kex2 protease inhibitor
has_related_synonym: Kex2 protease inhibitors
has_related_synonym: Kex2 proteinase inhibitor
has_related_synonym: Kex2 proteinase inhibitors
has_related_synonym: Kex2-like endoproteinase inhibitor
has_related_synonym: Kex2-like endoproteinase inhibitors
has_related_synonym: Kex2-like precursor protein processing endoprotease inhibitor
has_related_synonym: Kex2-like precursor protein processing endoprotease inhibitors
has_related_synonym: andrenorphin-Gly-generating enzyme inhibitor
has_related_synonym: andrenorphin-Gly-generating enzyme inhibitors
has_related_synonym: endoproteinase Kex2p inhibitor
has_related_synonym: endoproteinase Kex2p inhibitors
has_related_synonym: gene KEX2 dibasic proteinase inhibitor
has_related_synonym: gene KEX2 dibasic proteinase inhibitors
has_related_synonym: kexin inhibitor
has_related_synonym: kexin inhibitors
has_related_synonym: paired-basic endopeptidase inhibitor
has_related_synonym: paired-basic endopeptidase inhibitors
has_related_synonym: prohormone-processing KEX2 proteinase inhibitor
has_related_synonym: prohormone-processing KEX2 proteinase inhibitors
has_related_synonym: prohormone-processing endoprotease inhibitor
has_related_synonym: prohormone-processing endoprotease inhibitors
has_related_synonym: prohormone-processing proteinase inhibitor
has_related_synonym: prohormone-processing proteinase inhibitors
has_related_synonym: proprotein convertase inhibitor
has_related_synonym: proprotein convertase inhibitors
has_related_synonym: protease KEX2 inhibitor
has_related_synonym: protease KEX2 inhibitors
has_related_synonym: proteinase Kex2p inhibitor
has_related_synonym: proteinase Kex2p inhibitors
has_related_synonym: proteinase yscF inhibitor
has_related_synonym: proteinase yscF inhibitors
has_related_synonym: yeast KEX2 protease inhibitor
has_related_synonym: yeast KEX2 protease inhibitors
id: CHEBI:189665
in subset: 3 STAR

PAR2 negative allosteric modulator
type: Class
subclass of: protease-activated receptor-2 antagonist
subclass of: receptor modulator
textual definition: a group of substances that bind to a receptor to change that receptor's response to stimulus.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:189675
in subset: 2 STAR

protease-activated receptor-2 antagonist
type: Class
subclass of: G-protein-coupled receptor antagonist
textual definition: An antagonist at the protease-activated receptor-2.
imported from: chebi.owl
has cross-reference: PMID:10657317
has cross-reference: Wikipedia:Protease-activated_receptor_2
has_obo_namespace: chebi_ontology
has_related_synonym: G-protein coupled receptor 11 antagonist
has_related_synonym: G-protein coupled receptor 11 antagonists
has_related_synonym: GPR11 antagonist
has_related_synonym: GPR11 antagonists
has_related_synonym: PAR-2 antagonist
has_related_synonym: PAR-2 antagonists
has_related_synonym: PAR2 antagonist
has_related_synonym: PAR2 antagonists
has_related_synonym: coagulation factor II (thrombin) receptor-like 1 antagonist
has_related_synonym: coagulation factor II (thrombin) receptor-like 1 antagonists
has_related_synonym: protease-activated receptor 2 antagonist
has_related_synonym: protease-activated receptor 2 antagonists
has_related_synonym: protease-activated receptor-2 antagonists
id: CHEBI:189676
in subset: 3 STAR

sigma receptor modulator
type: Class
subclass of: receptor modulator
textual definition: Any receptor modulator acting on sigma receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Sigma_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: sigma receptor modulators
has_related_synonym: sigma-receptor modulator
has_related_synonym: sigma-receptor modulators
id: CHEBI:189683
in subset: 3 STAR

sigma-2 receptor agonist
type: Class
subclass of: sigma receptor modulator
textual definition: A sigma receptor modulator that activates the sigma-2 receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Sigma-2_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: sigma 2 receptor agonist
has_related_synonym: sigma 2 receptor agonists
has_related_synonym: sigma-2 receptor agonists
has_related_synonym: sigma2 receptor agonist
has_related_synonym: sigma2 receptor agonists
has_related_synonym: sigma2R agonist
has_related_synonym: sigma2R agonists
id: CHEBI:189684
in subset: 3 STAR

ceramide mimetic
type: Class
subclass of: biological role
textual definition: Any compound that mimics the activity of a ceramide, e.g. by inducing tumor cell death or suppression.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ceramide mimetics
id: CHEBI:190286
in subset: 3 STAR

EC 3.2.1.24 (alpha-mannosidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-mannosidase (EC 3.2.1.24).
imported from: chebi.owl
has cross-reference: Wikipedia:Alpha-Mannosidase
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2-alpha-D-mannosidase inhibitor
has_related_synonym: 1,2-alpha-D-mannosidase inhibitors
has_related_synonym: 1,2-alpha-mannosidase inhibitor
has_related_synonym: 1,2-alpha-mannosidase inhibitors
has_related_synonym: EC 3.2.1.24 (alpha-mannosidase) inhibitors
has_related_synonym: EC 3.2.1.24 inhibitor
has_related_synonym: EC 3.2.1.24 inhibitors
has_related_synonym: alpha-D-mannopyranosidase inhibitor
has_related_synonym: alpha-D-mannopyranosidase inhibitors
has_related_synonym: alpha-D-mannosidase inhibitor
has_related_synonym: alpha-D-mannosidase inhibitors
has_related_synonym: alpha-mannosidase inhibitor
has_related_synonym: alpha-mannosidase inhibitors
has_related_synonym: exo-alpha-mannosidase inhibitor
has_related_synonym: exo-alpha-mannosidase inhibitors
has_related_synonym: p-nitrophenyl-alpha-mannosidase inhibitor
has_related_synonym: p-nitrophenyl-alpha-mannosidase inhibitors
id: CHEBI:191196
in subset: 3 STAR

CB1 receptor agonist
type: Class
subclass of: cannabinoid receptor agonist
textual definition: A cannabinoid receptor agonist that binds to and activates type 1 cannabinoid receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Cannabinoid_receptor_type_1
alternative_term: CB1 receptor agonist
has_obo_namespace: chebi_ontology
has_related_synonym: CB1 receptor agonists
has_related_synonym: CB1R agonist
has_related_synonym: CB1R agonists
has_related_synonym: cannabinoid receptor 1 agonist
has_related_synonym: cannabinoid receptor 1 agonists
has_related_synonym: cannabinoid receptor type 1 agonist
has_related_synonym: cannabinoid receptor type 1 agonists
has_related_synonym: type 1 cannabinoid receptor agonist
has_related_synonym: type 1 cannabinoid receptor agonists
id: CHEBI:192269
in subset: 3 STAR

elicitor
type: Class
subclass of: biochemical role
textual definition: A chemical or biochemical compound that is introduced in small concentrations to a living system to promote the biosynthesis of the target bioactive compound.
imported from: chebi.owl
has cross-reference: PMID:25969762
has cross-reference: Wikipedia:Elicitor
has_obo_namespace: chebi_ontology
has_related_synonym: elicitors
id: CHEBI:192504
in subset: 2 STAR

EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitor
type: Class
subclass of: EC 6.2.1.* (acid-thiol ligase) inhibitor
textual definition: An EC 6.2.1.* (acid-thiol ligase) inhibitor that interferes with the action of E1 ubiquitin-activating enzyme (EC 6.2.1.45).
imported from: chebi.owl
has cross-reference: Wikipedia:Ubiquitin-activating_enzyme
has_obo_namespace: chebi_ontology
has_related_synonym: E1 inhibitor
has_related_synonym: E1 inhibitors
has_related_synonym: E1 ubiquitin-activating enzyme inhibitor
has_related_synonym: E1 ubiquitin-activating enzyme inhibitors
has_related_synonym: EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitors
has_related_synonym: EC 6.2.1.45 inhibitor
has_related_synonym: EC 6.2.1.45 inhibitors
has_related_synonym: ubiquitin activating enzyme inhibitor
has_related_synonym: ubiquitin activating enzyme inhibitors
has_related_synonym: ubiquitin-activating enzyme E1 inhibitor
has_related_synonym: ubiquitin-activating enzyme E1 inhibitors
id: CHEBI:192999
in subset: 3 STAR

neurokinin-1 receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist at the neurokinin-1 receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NK-1 receptor agonist
has_related_synonym: NK-1 receptor agonists
has_related_synonym: NK1 receptor agonist
has_related_synonym: NK1 receptor agonists
has_related_synonym: neurokinin-1 receptor agonists
id: CHEBI:194137
in subset: 3 STAR

protease-activated receptor-1 agonist
type: Class
subclass of: G-protein-coupled receptor agonist
textual definition: An agonist at the protease-activated receptor-1.
imported from: chebi.owl
has cross-reference: PMID:11487506
has cross-reference: PMID:12606620
has cross-reference: PMID:29343648
has cross-reference: Wikipedia:Coagulation_factor_II_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: PAR-1 agonist
has_related_synonym: PAR-1 agonists
has_related_synonym: PAR-1 receptor agonist
has_related_synonym: PAR-1 receptor agonists
has_related_synonym: PAR1 agonist
has_related_synonym: PAR1 agonists
has_related_synonym: coagulation factor II (thrombin) receptor agonist
has_related_synonym: coagulation factor II (thrombin) receptor agonists
has_related_synonym: coagulation factor II receptor agonist
has_related_synonym: coagulation factor II receptor agonists
has_related_synonym: coagulation factor II thrombin receptor agonist
has_related_synonym: coagulation factor II thrombin receptor agonists
has_related_synonym: protease activated receptor 1 agonist
has_related_synonym: protease activated receptor 1 agonists
has_related_synonym: protease-activated receptor 1 agonist
has_related_synonym: protease-activated receptor 1 agonists
has_related_synonym: protease-activated receptor-1 agonists
has_related_synonym: proteinase-activated receptor 1 agonist
has_related_synonym: proteinase-activated receptor 1 agonists
id: CHEBI:194153
in subset: 3 STAR

piezo1 agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates piezo1 receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:PIEZO1
alternative_term: PIEZO1 agonist
has_obo_namespace: chebi_ontology
has_related_synonym: PIEZO1 agonists
has_related_synonym: piezo type mechanosensitive ion channel component 1 agonist
has_related_synonym: piezo type mechanosensitive ion channel component 1 agonists
has_related_synonym: piezo-type mechanosensitive ion channel component 1 agonist
has_related_synonym: piezo-type mechanosensitive ion channel component 1 agonists
has_related_synonym: piezo1 agonists
id: CHEBI:194154
in subset: 3 STAR

mitochondrial calcium uniporter inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor of mitochondrial calcium uniporter.
imported from: chebi.owl
has cross-reference: Wikipedia:Mitochondrial_calcium_uniporter
has_obo_namespace: chebi_ontology
has_related_synonym: MCU inhibitor
has_related_synonym: MCU inhibitors
has_related_synonym: mitochondrial calcium uniporter blocker
has_related_synonym: mitochondrial calcium uniporter blockers
has_related_synonym: mitochondrial calcium uniporter inhibitors
id: CHEBI:194181
in subset: 3 STAR

gastric inhibitory polypeptide receptor agonist
type: Class
subclass of: G-protein-coupled receptor agonist
textual definition: An agonist that binds to and activates gastric inhibitory polypeptide (GIP) receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Gastric_inhibitory_polypeptide_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: GIP agonist
has_related_synonym: GIP agonists
has_related_synonym: GIP receptor agonist
has_related_synonym: GIP receptor agonists
has_related_synonym: GIP-R agonist
has_related_synonym: GIP-R agonists
has_related_synonym: GIPR agonist
has_related_synonym: GIPR agonists
has_related_synonym: gastric inhibitory polypeptide receptor agonists
has_related_synonym: glucose-dependent insulinotropic polypeptide receptor agonist
has_related_synonym: glucose-dependent insulinotropic polypeptide receptor agonists
id: CHEBI:194187
in subset: 3 STAR

T-type calcium channel blocker
type: Class
subclass of: calcium channel blocker
textual definition: Any agent that interferes with the activity of T-type calcium channels.
imported from: chebi.owl
has cross-reference: PMID:30372652
has cross-reference: PMID:36738196
has cross-reference: Wikipedia:T-type_calcium_channel
has_obo_namespace: chebi_ontology
has_related_synonym: T-type calcium channel antagonist
has_related_synonym: T-type calcium channel antagonists
has_related_synonym: T-type calcium channel blockers
id: CHEBI:194338
in subset: 3 STAR

aquaretic
type: Class
subclass of: diuretic
textual definition: A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss).
imported from: chebi.owl
has cross-reference: PMID:12107918
has cross-reference: PMID:17430186
has cross-reference: PMID:21088744
has cross-reference: PMID:24853354
has cross-reference: PMID:28194573
has cross-reference: PMID:28652798
has cross-reference: PMID:29259382
has cross-reference: PMID:36156485
has cross-reference: PMID:8738740
has cross-reference: PMID:8998673
has cross-reference: Wikipedia:Aquaretic
has_obo_namespace: chebi_ontology
has_related_synonym: aquaretic agent
has_related_synonym: aquaretic agents
has_related_synonym: aquaretics
id: CHEBI:194423
in subset: 3 STAR

antimyopathic agent
type: Class
subclass of: drug
textual definition: A drug used to treat myopathy.
imported from: chebi.owl
has cross-reference: Wikipedia:Myopathy
has_obo_namespace: chebi_ontology
has_related_synonym: antimyopathic agents
has_related_synonym: antimyopathic drug
has_related_synonym: antimyopathic drugs
id: CHEBI:194430
in subset: 3 STAR

NOD1 agonist
type: Class
subclass of: agonist
textual definition: An agonist that activates NOD1 receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:NOD1
has_obo_namespace: chebi_ontology
has_related_synonym: CARD4 agonist
has_related_synonym: CARD4 agonists
has_related_synonym: CLR7.1 agonist
has_related_synonym: CLR7.1 agonists
has_related_synonym: NOD1 agonists
has_related_synonym: caspase recruitment domain-containing protein 4 agonist
has_related_synonym: caspase recruitment domain-containing protein 4 agonists
has_related_synonym: nucleotide binding oligomerization domain containing 1 agonist
has_related_synonym: nucleotide binding oligomerization domain containing 1 agonists
has_related_synonym: nucleotide-binding oligomerization domain-containing protein 1 agonist
has_related_synonym: nucleotide-binding oligomerization domain-containing protein 1 agonists
id: CHEBI:194467
in subset: 3 STAR

activator
type: Class
subclass of: biological role
textual definition: A substance that increases the rate of a chemical reaction.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: activators
id: CHEBI:195251
in subset: 3 STAR

enzyme activator
type: Class
subclass of: activator
subclass of: biochemical role
textual definition: An activator of an enzyme-catalysed reaction.
imported from: chebi.owl
has cross-reference: Wikipedia:Enzyme_activator
has_obo_namespace: chebi_ontology
has_related_synonym: enzyme activators
id: CHEBI:195252
in subset: 3 STAR

EC 2.6.1.13 (ornithine aminotransferase) inhibitor
type: Class
subclass of: EC 2.6.1.* (transaminase) inhibitor
textual definition: An EC 2.6.1.* (transaminase) inhibitor that interferes with the action of ornithine aminotransferase (EC 2.6.1.13).
imported from: chebi.owl
has cross-reference: Wikipedia:Ornithine_aminotransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.6.1.13 (ornithine aminotransferase) inhibitors
has_related_synonym: EC 2.6.1.13 inhibitor
has_related_synonym: EC 2.6.1.13 inhibitors
has_related_synonym: L-ornithine 5-aminotransferase inhibitor
has_related_synonym: L-ornithine 5-aminotransferase inhibitors
has_related_synonym: L-ornithine aminotransferase inhibitor
has_related_synonym: L-ornithine aminotransferase inhibitors
has_related_synonym: L-ornithine:alpha-ketoglutarate -aminotransferase inhibitor
has_related_synonym: L-ornithine:alpha-ketoglutarate -aminotransferase inhibitors
has_related_synonym: OAT inhibitor
has_related_synonym: OAT inhibitors
has_related_synonym: ornithine 5-aminotransferase inhibitor
has_related_synonym: ornithine 5-aminotransferase inhibitors
has_related_synonym: ornithine aminotransferase inhibitor
has_related_synonym: ornithine aminotransferase inhibitors
has_related_synonym: ornithine delta-transaminase inhibitor
has_related_synonym: ornithine delta-transaminase inhibitors
has_related_synonym: ornithine transaminase inhibitor
has_related_synonym: ornithine transaminase inhibitors
has_related_synonym: ornithine--oxo-acid transaminase inhibitor
has_related_synonym: ornithine--oxo-acid transaminase inhibitors
has_related_synonym: ornithine-2-oxoacid aminotransferase inhibitor
has_related_synonym: ornithine-2-oxoacid aminotransferase inhibitors
has_related_synonym: ornithine-alpha-ketoglutarate aminotransferase inhibitor
has_related_synonym: ornithine-alpha-ketoglutarate aminotransferase inhibitors
has_related_synonym: ornithine-keto acid aminotransferase inhibitor
has_related_synonym: ornithine-keto acid aminotransferase inhibitors
has_related_synonym: ornithine-keto acid transaminase inhibitor
has_related_synonym: ornithine-keto acid transaminase inhibitors
has_related_synonym: ornithine-ketoglutarate aminotransferase inhibitor
has_related_synonym: ornithine-ketoglutarate aminotransferase inhibitors
has_related_synonym: ornithine-oxo acid aminotransferase inhibitor
has_related_synonym: ornithine-oxo acid aminotransferase inhibitors
has_related_synonym: ornithine:alpha-oxoglutarate transaminase inhibitor
has_related_synonym: ornithine:alpha-oxoglutarate transaminase inhibitors
id: CHEBI:195331
in subset: 3 STAR

insulin-like growth factor-binding protein inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor that acts on insulin-like growth factor-binding proteins.
imported from: chebi.owl
has cross-reference: Wikipedia:Insulin-like_growth_factor-binding_protein
has_obo_namespace: chebi_ontology
has_related_synonym: IGFBP inhibitor
has_related_synonym: IGFBP inhibitors
has_related_synonym: insulin-like growth factor-binding protein inhibitors
id: CHEBI:195444
in subset: 3 STAR

EC 2.7.12.1 (dual-specificity kinase) inhibitor
type: Class
subclass of: EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor
textual definition: An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of dual-specificity kinase (EC 2.7.12.1).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ADK1 inhibitor
has_related_synonym: ADK1 inhibitors
has_related_synonym: Arabidopsis dual specificity kinase 1 inhibitor
has_related_synonym: Arabidopsis dual specificity kinase 1 inhibitors
has_related_synonym: CLK1 inhibitor
has_related_synonym: CLK1 inhibitors
has_related_synonym: EC 2.7.12.1 (dual-specificity kinase) inhibitors
has_related_synonym: EC 2.7.12.1 inhibitor
has_related_synonym: EC 2.7.12.1 inhibitors
has_related_synonym: Mps1p inhibitor
has_related_synonym: Mps1p inhibitors
has_related_synonym: dDYRK2 inhibitor
has_related_synonym: dDYRK2 inhibitors
has_related_synonym: dual-specificity kinase inhibitor
has_related_synonym: dual-specificity kinase inhibitors
id: CHEBI:195525
in subset: 3 STAR

PCNA inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: An inhibitor that interferes with the action of PCNA.
imported from: chebi.owl
has cross-reference: PMID:25729582
has cross-reference: PMID:37486931
has cross-reference: PMID:37511614
has cross-reference: Wikipedia:Proliferating_cell_nuclear_antigen
has_obo_namespace: chebi_ontology
has_related_synonym: PCNA inhibitors
has_related_synonym: proliferating cell nuclear antigen inhibitor
has_related_synonym: proliferating cell nuclear antigen inhibitors
id: CHEBI:195530
in subset: 3 STAR

sphingosine-1-phosphate receptor 2 antagonist
type: Class
subclass of: sphingosine-1-phosphate receptor antagonist
textual definition: Any sphingosine-1-phosphate receptor (S1PR) antagonist that acts as an antagonist for the subtype 2 receptors (S1PR2).
imported from: chebi.owl
has cross-reference: PMID:25746814
has cross-reference: PMID:26384288
has cross-reference: PMID:26794040
has cross-reference: PMID:28676392
has cross-reference: PMID:34411894
has cross-reference: PMID:36527992
has cross-reference: Wikipedia:S1PR2
has_obo_namespace: chebi_ontology
has_related_synonym: EDG-5 antagonist
has_related_synonym: EDG-5 antagonists
has_related_synonym: EDG5 antagonist
has_related_synonym: EDG5 antagonists
has_related_synonym: S1P2 antagonist
has_related_synonym: S1P2 antagonists
has_related_synonym: S1PR2 antagonist
has_related_synonym: S1PR2 antagonists
has_related_synonym: sphingosine-1-phosphate receptor 2 antagonists
id: CHEBI:195542
in subset: 3 STAR

EC 3.5.3.1 (arginase) inhibitor
type: Class
subclass of: EC 3.5.3.* (non-peptide linear amidine C-N hydrolase) inhibitor
textual definition: An EC 3.5.3.* (non-peptide linear amidine C-N hydrolase) inhibitor that interferes with the action of arginase (EC 3.5.3.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Arginase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.3.1 (arginase) inhibitors
has_related_synonym: EC 3.5.3.1 inhibitor
has_related_synonym: EC 3.5.3.1 inhibitors
has_related_synonym: L-arginase inhibitor
has_related_synonym: L-arginase inhibitors
has_related_synonym: arginase inhibitor
has_related_synonym: arginase inhibitors
has_related_synonym: arginine amidinase inhibitor
has_related_synonym: arginine amidinase inhibitors
has_related_synonym: arginine transamidinase inhibitor
has_related_synonym: arginine transamidinase inhibitors
has_related_synonym: canavanase inhibitor
has_related_synonym: canavanase inhibitors
id: CHEBI:195561
in subset: 3 STAR

EC 3.5.3.* (non-peptide linear amidine C-N hydrolase) inhibitor
type: Class
subclass of: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
textual definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amidine C-N hydrolase (EC 3.5.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.3.* (non-peptide linear amidine C-N hydrolase) inhibitors
has_related_synonym: EC 3.5.3.* inhibitor
has_related_synonym: EC 3.5.3.* inhibitors
has_related_synonym: non-peptide linear amidine C-N hydrolase (EC 3.5.3.*) inhibitor
has_related_synonym: non-peptide linear amidine C-N hydrolase (EC 3.5.3.*) inhibitors
id: CHEBI:195562
in subset: 3 STAR

calcitonin gene-related peptide receptor antagonist
type: Class
subclass of: G-protein-coupled receptor antagonist
textual definition: An antagonist at any calcitonin gene-related peptide receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Calcitonin_gene-related_peptide_receptor_antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: CGRP antagonist
has_related_synonym: CGRP antagonists
has_related_synonym: calcitonin gene-related peptide receptor antagonists
id: CHEBI:196956
in subset: 3 STAR

Rac1 inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor of Rac1.
imported from: chebi.owl
has cross-reference: PMID:19527032
has cross-reference: Wikipedia:RAC1
has_obo_namespace: chebi_ontology
has_related_synonym: Rac-1 inhibitor
has_related_synonym: Rac-1 inhibitors
has_related_synonym: Rac1 inhibitors
has_related_synonym: Ras-related C3 botulinum toxin substrate 1 inhibitor
has_related_synonym: Ras-related C3 botulinum toxin substrate 1 inhibitors
id: CHEBI:197347
in subset: 3 STAR

NMR solvent
type: Class
subclass of: solvent
textual definition: A solvent used in nuclear magnetic resonance (NMR) spectroscopy.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NMR solvents
has_related_synonym: NMR-Loesemittel
has_related_synonym: NMR-Loesungsmittel
id: CHEBI:197449
in subset: 3 STAR

EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 3-enol-pyruvoylshikimate-5-phosphate synthase inhibitor
has_related_synonym: 3-enol-pyruvoylshikimate-5-phosphate synthase inhibitors
has_related_synonym: 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) inhibitor
has_related_synonym: 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) inhibitors
has_related_synonym: 3-phosphoshikimate 1-carboxyvinyltransferase inhibitor
has_related_synonym: 3-phosphoshikimate 1-carboxyvinyltransferase inhibitors
has_related_synonym: 5-enolpyruvylshikimate-3-phosphate synthase inhibitor
has_related_synonym: 5-enolpyruvylshikimate-3-phosphate synthase inhibitors
has_related_synonym: EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitors
has_related_synonym: EC 2.5.1.19 inhibitor
has_related_synonym: EC 2.5.1.19 inhibitors
has_related_synonym: EPSP synthase inhibitor
has_related_synonym: EPSP synthase inhibitors
has_related_synonym: phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase inhibitor
has_related_synonym: phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase inhibitors
id: CHEBI:20569
in subset: 3 STAR

ATP synthase inhibitor
type: Class
subclass of: mitochondrial respiratory-chain inhibitor
subclass of: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
textual definition: A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:20854
in subset: 3 STAR

acaricide
type: Class
subclass of: pesticide
textual definition: A substance used to destroy pests of the subclass Acari (mites and ticks).
imported from: chebi.owl
has cross-reference: Wikipedia:Acaricide
has_obo_namespace: chebi_ontology
has_related_synonym: Akarizid
has_related_synonym: Akarizide
has_related_synonym: acaricides
has_related_synonym: miticide
id: CHEBI:22153
in subset: 3 STAR

EC 2.2.1.6 (acetolactate synthase) inhibitor
type: Class
subclass of: EC 2.2.1.* (transketolase/transaldolase) inhibitor
textual definition: An EC 2.2.1.* (transketolase/transaldolase) inhibitor that interferes with the action of acetolactate synthase (EC 2.2.1.6).
imported from: chebi.owl
has cross-reference: Wikipedia:Acetolactate_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.2.1.6 (acetolactate synthase) inhibitors
has_related_synonym: EC 2.2.1.6 inhibitor
has_related_synonym: EC 2.2.1.6 inhibitors
has_related_synonym: acetohydroxy acid synthetase inhibitor
has_related_synonym: acetohydroxy acid synthetase inhibitors
has_related_synonym: acetohydroxyacid synthase inhibitor
has_related_synonym: acetohydroxyacid synthase inhibitors
has_related_synonym: acetolactate pyruvate-lyase (carboxylating) inhibitor
has_related_synonym: acetolactate pyruvate-lyase (carboxylating) inhibitors
has_related_synonym: acetolactate synthase (EC 2.2.1.6) inhibitor
has_related_synonym: acetolactate synthase (EC 2.2.1.6) inhibitors
has_related_synonym: acetolactate synthase inhibitor
has_related_synonym: acetolactate synthase inhibitors
has_related_synonym: acetolactic synthetase inhibitor
has_related_synonym: acetolactic synthetase inhibitors
has_related_synonym: alpha-acetohydroxy acid synthetase inhibitor
has_related_synonym: alpha-acetohydroxy acid synthetase inhibitors
has_related_synonym: alpha-acetohydroxyacid synthase inhibitor
has_related_synonym: alpha-acetohydroxyacid synthase inhibitors
has_related_synonym: alpha-acetolactate synthase inhibitor
has_related_synonym: alpha-acetolactate synthase inhibitors
has_related_synonym: alpha-acetolactate synthetase inhibitor
has_related_synonym: alpha-acetolactate synthetase inhibitors
has_related_synonym: pyruvate:pyruvate acetaldehydetransferase (decarboxylating) inhibitor
has_related_synonym: pyruvate:pyruvate acetaldehydetransferase (decarboxylating) inhibitors
id: CHEBI:22180
in subset: 3 STAR

alicyclic antibiotics
type: Class
subclass of: antimicrobial agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22309
in subset: 1 STAR

aliphatic antibiotics
type: Class
subclass of: antimicrobial agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22311
in subset: 1 STAR

alkylating agent
type: Class
subclass of: mutagen
textual definition: Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22333
in subset: 3 STAR

alpha-1-microglobulin-Ig alpha complex chromophores
type: Class
subclass of: chromophore
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22368
in subset: 1 STAR

amino acid derivative antibiotics
type: Class
subclass of: antimicrobial agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22476
in subset: 1 STAR

antiauxins
type: Class
subclass of: plant growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22581
in subset: 1 STAR

antifeedant
type: Class
subclass of: pesticide
textual definition: A substance that prevents pests from feeding.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antifeedants
id: CHEBI:22583
in subset: 3 STAR

antioxidant
type: Class
subclass of: chemical role
textual definition: A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antioxidants
has_related_synonym: antioxydant
has_related_synonym: antoxidant
id: CHEBI:22586
in subset: 3 STAR

antiviral agent
type: Class
subclass of: antimicrobial agent
textual definition: A substance that destroys or inhibits replication of viruses.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-viral agent
has_related_synonym: anti-viral agents
has_related_synonym: antiviral
has_related_synonym: antiviral agents
has_related_synonym: antivirals
id: CHEBI:22587
in subset: 3 STAR

auxin
type: Class
subclass of: plant hormone
textual definition: Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").
imported from: chebi.owl
has cross-reference: Wikipedia:Auxin
has_obo_namespace: chebi_ontology
has_related_synonym: auxins
id: CHEBI:22676
in subset: 3 STAR

base
type: Class
subclass of: chemical role
textual definition: A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).
imported from: chebi.owl
has cross-reference: KEGG:C00701
alternative_term: Base
alternative_term: base
has_obo_namespace: chebi_ontology
has_related_synonym: Base1
has_related_synonym: Base2
has_related_synonym: Basen
has_related_synonym: Nucleobase
has_related_synonym: bases
id: CHEBI:22695
in subset: 3 STAR

antinociceptive agent
type: Class
subclass of: drug
subclass of: pharmacological role
textual definition: Any agent that inhibits nociception.
imported from: chebi.owl
has cross-reference: PMID:37851902
has_obo_namespace: chebi_ontology
has_related_synonym: antinociceptive agents
id: CHEBI:228138
in subset: 3 STAR

C3a receptor antagonist
type: Class
subclass of: G-protein-coupled receptor antagonist
textual definition: Any antagonist of the C3a receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:C3a_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: C3AR1 antagonist
has_related_synonym: C3AR1 antagonists
has_related_synonym: C3a receptor antagonists
has_related_synonym: complement component 3a receptor 1 antagonist
has_related_synonym: complement component 3a receptor 1 antagonists
id: CHEBI:228139
in subset: 3 STAR

sigma-1 receptor agonist
type: Class
subclass of: sigma receptor modulator
textual definition: A sigma receptor modulator that activates the sigma-1 receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Sigma-1_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: sigma 1 receptor agonist
has_related_synonym: sigma 1 receptor agonists
has_related_synonym: sigma-1 receptor agonists
has_related_synonym: sigma1 receptor agonist
has_related_synonym: sigma1 receptor agonists
has_related_synonym: sigma1R agonist
has_related_synonym: sigma1R agonists
id: CHEBI:228237
in subset: 3 STAR

PNU-74654
type: Class
subclass of: Wnt signalling inhibitor
textual definition: beta-catenin - TCF interaction inhibitor
imported from: chebi.owl
charge: 0
formula: C19H16N2O3
inchi: InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
inchikey: JJEDWBQZCRESJL-DEDYPNTBSA-N
mass: 320.348
monoisotopicmass: 320.11609
has cross-reference: CAS:113906-27-7
has_obo_namespace: chebi_ontology
has_related_synonym: Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide
has_related_synonym: PNU 74654
has_related_synonym: PNU74654
id: CHEBI:228251
in subset: 2 STAR

EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ASH1L inhibitor
has_related_synonym: ASH1L inhibitors
has_related_synonym: EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitors
has_related_synonym: EC 2.1.1.354 inhibitor
has_related_synonym: EC 2.1.1.354 inhibitors
has_related_synonym: KMT2H inhibitor
has_related_synonym: KMT2H inhibitors
has_related_synonym: KMT3C inhibitor
has_related_synonym: KMT3C inhibitors
has_related_synonym: KMT3D inhibitor
has_related_synonym: KMT3D inhibitors
has_related_synonym: KMT3E inhibitor
has_related_synonym: KMT3E inhibitors
has_related_synonym: MLL5 inhibitor
has_related_synonym: MLL5 inhibitors
has_related_synonym: PRDM9 inhibitor
has_related_synonym: PRDM9 inhibitors
has_related_synonym: SMYD1 inhibitor
has_related_synonym: SMYD1 inhibitors
has_related_synonym: SMYD2 inhibitor
has_related_synonym: SMYD2 inhibitors
has_related_synonym: SMYD3 inhibitor
has_related_synonym: SMYD3 inhibitors
has_related_synonym: [histone H3]-lysine(4) N-trimethyltransferase inhibitor
has_related_synonym: [histone H3]-lysine(4) N-trimethyltransferase inhibitors
id: CHEBI:228263
in subset: 3 STAR

WNK signaling inhibitor
type: Class
subclass of: inhibitor
textual definition: A substance that inhibits any of the WNK signalling pathway.
imported from: chebi.owl
has cross-reference: PMID:28566208
has cross-reference: PMID:28881465
has_obo_namespace: chebi_ontology
has_related_synonym: WNK signaling inhibitors
has_related_synonym: WNK signalling inhibitor
has_related_synonym: WNK signalling inhibitors
has_related_synonym: WNK-signaling inhibitor
has_related_synonym: WNK-signaling inhibitors
has_related_synonym: WNK-signalling inhibitor
has_related_synonym: WNK-signalling inhibitors
has_related_synonym: lysine deficient protein kinase (WNK) signaling inhibitor
has_related_synonym: lysine deficient protein kinase (WNK) signaling inhibitors
has_related_synonym: with no lysine [K] (WNK) pathway inhibitor
has_related_synonym: with no lysine [K] (WNK) pathway inhibitors
has_related_synonym: with-no-lysine (WNK) protein kinase signaling inhibitor
has_related_synonym: with-no-lysine (WNK) protein kinase signaling inhibitors
id: CHEBI:228284
in subset: 3 STAR

trace amine-associated receptor 1 agonist
type: Class
subclass of: G-protein-coupled receptor agonist
textual definition: An agonist that selectively binds to and activates trace amine-associated receptor 1.
imported from: chebi.owl
has cross-reference: Wikipedia:TAAR1
has_obo_namespace: chebi_ontology
has_related_synonym: TA1 receptor agonist
has_related_synonym: TA1 receptor agonists
has_related_synonym: TAAR1 agonist
has_related_synonym: TAAR1 agonists
has_related_synonym: trace amine 1 (TA1) receptor agonist
has_related_synonym: trace amine 1 (TA1) receptor agonists
has_related_synonym: trace amine 1 receptor agonist
has_related_synonym: trace amine 1 receptor agonists
has_related_synonym: trace amine associated receptor 1 agonist
has_related_synonym: trace amine associated receptor 1 agonists
has_related_synonym: trace amine-associated receptor 1 agonists
id: CHEBI:228347
in subset: 3 STAR

NMR chemical shift reference compound
type: Class
subclass of: application
subclass of: chemical role
textual definition: Any compound that produces a peak used as reference frequency in the delta chemical shift scale.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NMR chemical shift reference compounds
has_related_synonym: NMR chemical shift standard
has_related_synonym: NMR chemical shift standards
has_related_synonym: NMR internal standard
has_related_synonym: NMR internal standards
has_related_synonym: NMR reference standard
has_related_synonym: NMR reference standards
id: CHEBI:228364
in subset: 3 STAR

heat shock factor 1 inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor that interferes with the action of heat shock factor 1.
imported from: chebi.owl
has cross-reference: Wikipedia:HSF1
has_obo_namespace: chebi_ontology
has_related_synonym: HSF 1 inhibitor
has_related_synonym: HSF 1 inhibitors
has_related_synonym: HSF-1 inhibitor
has_related_synonym: HSF-1 inhibitors
has_related_synonym: HSF1 inhibitor
has_related_synonym: HSF1 inhibitors
has_related_synonym: heat shock factor 1 inhibitors
has_related_synonym: heat shock factor protein 1 inhibitor
has_related_synonym: heat shock factor protein 1 inhibitors
has_related_synonym: heat shock factor-1 inhibitor
has_related_synonym: heat shock factor-1 inhibitors
id: CHEBI:228801
in subset: 3 STAR

phytogenic insecticide
type: Class
subclass of: insecticide
textual definition: An insecticide compound naturally occurring in plants.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: botanical insecticide
has_related_synonym: botanical insecticides
has_related_synonym: phytogenic insecticides
id: CHEBI:22917
in subset: 3 STAR

sodium-glucose transport protein subtype 1 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor that interferes with the action of sodium-glucose transport protein subtype 1.
imported from: chebi.owl
has cross-reference: Wikipedia:Sodium/glucose_cotransporter_1
has_obo_namespace: chebi_ontology
has_related_synonym: SGLT1 inhibitor
has_related_synonym: SGLT1 inhibitors
has_related_synonym: sodium glucose co-transporter 1 inhibitor
has_related_synonym: sodium glucose co-transporter 1 inhibitors
has_related_synonym: sodium-glucose transport protein subtype 1 inhibitors
has_related_synonym: sodium/glucose cotransporter 1 inhibitor
has_related_synonym: sodium/glucose cotransporter 1 inhibitors
has_related_synonym: solute carrier family 5 member 1 inhibitor
has_related_synonym: solute carrier family 5 member 1 inhibitors
id: CHEBI:229227
in subset: 3 STAR

EC 2.7.1.153 (phosphatidylinositol-4,5-bisphosphate 3-kinase) inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: Any EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153).
imported from: chebi.owl
has cross-reference: Wikipedia:Phosphatidylinositol-4,5-bisphosphate_3-kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase inhibitor
has_related_synonym: ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase inhibitors
has_related_synonym: EC 2.7.1.153 inhibitor
has_related_synonym: EC 2.7.1.153 inhibitors
has_related_synonym: phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor
has_related_synonym: phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors
has_related_synonym: type I phosphoinositide 3-kinase inhibitor
has_related_synonym: type I phosphoinositide 3-kinase inhibitors
id: CHEBI:229651
in subset: 3 STAR

complement factor B inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of complement factor B.
imported from: chebi.owl
has cross-reference: Wikipedia:Complement_factor_B
has_obo_namespace: chebi_ontology
has_related_synonym: CFB inhibitor
has_related_synonym: CFB inhibitors
has_related_synonym: complement factor B inhibitors
id: CHEBI:229655
in subset: 3 STAR

complement component 5 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of complement component 5.
imported from: chebi.owl
has cross-reference: Wikipedia:Complement_component_5
has_obo_namespace: chebi_ontology
has_related_synonym: C5 inhibitor
has_related_synonym: C5 inhibitors
has_related_synonym: complement component 5 inhibitors
id: CHEBI:229668
in subset: 3 STAR

IAP antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist of the inhibitor of apoptosis proteins. Inhibitors of apoptosis proteins (IAP) are a family of functionally and structurally related proteins that serve as endogenous inhibitors of programmed cell death (apoptosis).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: IAP antagonists
has_related_synonym: inhibitor of apoptosis protein antagonist
has_related_synonym: inhibitor of apoptosis protein antagonists
id: CHEBI:229692
in subset: 3 STAR

exportin 1 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of exportin 1.
imported from: chebi.owl
has cross-reference: PMID:37595020
has cross-reference: PMID:37899423
has cross-reference: PMID:38105606
has cross-reference: Wikipedia:XPO1
has_obo_namespace: chebi_ontology
has_related_synonym: CRM-1 inhibitor
has_related_synonym: CRM-1 inhibitors
has_related_synonym: CRM1 inhibitor
has_related_synonym: CRM1 inhibitors
has_related_synonym: SINE compound
has_related_synonym: SINE compounds
has_related_synonym: SINEs
has_related_synonym: XPO1 inhibitor
has_related_synonym: XPO1 inhibitors
has_related_synonym: chromosomal region maintenance 1 inhibitor
has_related_synonym: chromosomal region maintenance 1 inhibitors
has_related_synonym: exportin 1 inhibitors
has_related_synonym: exportin-1 inhibitor
has_related_synonym: exportin-1 inhibitors
has_related_synonym: selective inhibitor of nuclear export
has_related_synonym: selective inhibitors of nuclear export
id: CHEBI:229763
in subset: 3 STAR

glucose transporter inhibitor
type: Class
subclass of: inhibitor
textual definition: Any substance that inhibits the action of glucose transporters.
imported from: chebi.owl
has cross-reference: Wikipedia:Glucose_transporter
has_obo_namespace: chebi_ontology
has_related_synonym: glucose transporter inhibitors
id: CHEBI:229782
in subset: 3 STAR

glucose transporter 1 inhibitor
type: Class
subclass of: glucose transporter inhibitor
textual definition: Any glucose transporter inhibitor that interferes with the action of glucose transporter 1.
imported from: chebi.owl
has cross-reference: Wikipedia:GLUT1
has_obo_namespace: chebi_ontology
has_related_synonym: GLUT1 inhibitor
has_related_synonym: GLUT1 inhibitors
has_related_synonym: SLC2A1 inhibitor
has_related_synonym: SLC2A1 inhibitors
has_related_synonym: glucose transporter 1 inhibitors
has_related_synonym: solute carrier family 2, facilitated glucose transporter member 1 inhibitor
has_related_synonym: solute carrier family 2, facilitated glucose transporter member 1 inhibitors
id: CHEBI:229783
in subset: 3 STAR

calcium ionophore
type: Class
subclass of: ionophore
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: calcium ionophores
id: CHEBI:22986
in subset: 3 STAR

EC 4.2.1.1 (carbonic anhydrase) inhibitor
type: Class
subclass of: EC 4.2.1.* (hydro-lyases) inhibitor
textual definition: An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule.
imported from: chebi.owl
has cross-reference: Wikipedia:Carbonic_anhydrase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.2.1.1 (carbonic anhydrase) inhibitors
has_related_synonym: EC 4.2.1.1 inhibitor
has_related_synonym: EC 4.2.1.1 inhibitors
has_related_synonym: anhydrase inhibitor
has_related_synonym: anhydrase inhibitors
has_related_synonym: carbonate anhydrase inhibitor
has_related_synonym: carbonate anhydrase inhibitors
has_related_synonym: carbonate dehydratase inhibitor
has_related_synonym: carbonate dehydratase inhibitors
has_related_synonym: carbonate hydro-lyase (carbon-dioxide-forming) inhibitor
has_related_synonym: carbonate hydro-lyase (carbon-dioxide-forming) inhibitors
has_related_synonym: carbonate hydro-lyase inhibitor
has_related_synonym: carbonate hydro-lyase inhibitors
has_related_synonym: carbonic acid anhydrase inhibitor
has_related_synonym: carbonic acid anhydrase inhibitors
has_related_synonym: carbonic anhydrase (EC 4.2.1.1) inhibitor
has_related_synonym: carbonic anhydrase (EC 4.2.1.1) inhibitors
has_related_synonym: carbonic anhydrase A inhibitor
has_related_synonym: carbonic anhydrase A inhibitors
has_related_synonym: carbonic anhydrase inhibitor
has_related_synonym: carbonic anhydrase inhibitors
has_related_synonym: carboxyanhydrase inhibitor
has_related_synonym: carboxyanhydrase inhibitors
id: CHEBI:23018
in subset: 3 STAR

EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of 1,3-beta-glucan synthase (EC 2.4.1.34).
imported from: chebi.owl
has cross-reference: Wikipedia:1,3-Beta-glucan_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: (1,3)-beta-glucan (callose) synthase inhibitor
has_related_synonym: (1,3)-beta-glucan (callose) synthase inhibitors
has_related_synonym: 1,3-beta-D-glucan synthase inhibitor
has_related_synonym: 1,3-beta-D-glucan synthase inhibitors
has_related_synonym: 1,3-beta-D-glucan synthetase inhibitor
has_related_synonym: 1,3-beta-D-glucan synthetase inhibitors
has_related_synonym: 1,3-beta-D-glucan--UDP glucosyltransferase inhibitor
has_related_synonym: 1,3-beta-D-glucan--UDP glucosyltransferase inhibitors
has_related_synonym: 1,3-beta-D-glucan-UDP glucosyltransferase inhibitor
has_related_synonym: 1,3-beta-D-glucan-UDP glucosyltransferase inhibitors
has_related_synonym: 1,3-beta-glucan synthase inhibitor
has_related_synonym: 1,3-beta-glucan synthase inhibitors
has_related_synonym: 1,3-beta-glucan-uridine diphosphoglucosyltransferase inhibitor
has_related_synonym: 1,3-beta-glucan-uridine diphosphoglucosyltransferase inhibitors
has_related_synonym: EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitors
has_related_synonym: EC 2.4.1.34 inhibitor
has_related_synonym: EC 2.4.1.34 inhibitors
has_related_synonym: GS-II inhibitor
has_related_synonym: GS-II inhibitors
has_related_synonym: UDP-glucose--1,3-beta-D-glucan glucosyltransferase inhibitor
has_related_synonym: UDP-glucose--1,3-beta-D-glucan glucosyltransferase inhibitors
has_related_synonym: UDP-glucose-1,3-beta-D-glucan glucosyltransferase inhibitor
has_related_synonym: UDP-glucose-1,3-beta-D-glucan glucosyltransferase inhibitors
has_related_synonym: UDP-glucose-1,3-beta-glucan glucosyltransferase inhibitor
has_related_synonym: UDP-glucose-1,3-beta-glucan glucosyltransferase inhibitors
has_related_synonym: UDP-glucose-beta-glucan glucosyltransferase inhibitor
has_related_synonym: UDP-glucose-beta-glucan glucosyltransferase inhibitors
has_related_synonym: UDP-glucose:(1,3)beta-glucan synthase inhibitor
has_related_synonym: UDP-glucose:(1,3)beta-glucan synthase inhibitors
has_related_synonym: UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase inhibitor
has_related_synonym: UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase inhibitors
has_related_synonym: beta-1,3-glucan synthase inhibitor
has_related_synonym: beta-1,3-glucan synthase inhibitors
has_related_synonym: beta-1,3-glucan synthetase inhibitor
has_related_synonym: beta-1,3-glucan synthetase inhibitors
has_related_synonym: callose synthase inhibitor
has_related_synonym: callose synthase inhibitors
has_related_synonym: callose synthetase inhibitor
has_related_synonym: callose synthetase inhibitors
has_related_synonym: paramylon synthetase inhibitor
has_related_synonym: paramylon synthetase inhibitors
has_related_synonym: uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase inhibitor
has_related_synonym: uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase inhibitors
id: CHEBI:230471
in subset: 3 STAR

chemosterilant
type: Class
subclass of: pesticide
textual definition: A substance intended to sterilize any organism.
imported from: chebi.owl
has cross-reference: Wikipedia:Chemosterilant
has_obo_namespace: chebi_ontology
has_related_synonym: chemosterilants
id: CHEBI:23092
in subset: 3 STAR

chitin synthesis inhibitor
type: Class
subclass of: insect growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:23100
in subset: 1 STAR

EC 2.4.2.12 (nicotinamide phosphoribosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.2.* (pentosyltransferase) inhibitor
textual definition: An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of nicotinamide phosphoribosyltransferase (EC 2.4.2.12).
imported from: chebi.owl
has cross-reference: Wikipedia:Nicotinamide_phosphoribosyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.2.12 (nicotinamide phosphoribosyltransferase) inhibitor inhibitors
has_related_synonym: EC 2.4.2.12 inhibitor
has_related_synonym: EC 2.4.2.12 inhibitors
has_related_synonym: NAMPT inhibitor
has_related_synonym: NAMPT inhibitors
has_related_synonym: NAmPRTase inhibitor
has_related_synonym: NAmPRTase inhibitors
has_related_synonym: NMN pyrophosphorylase inhibitor
has_related_synonym: NMN pyrophosphorylase inhibitors
has_related_synonym: NMN synthetase inhibitor
has_related_synonym: NMN synthetase inhibitors
has_related_synonym: nicotinamide mononucleotide pyrophosphorylase inhibitor
has_related_synonym: nicotinamide mononucleotide pyrophosphorylase inhibitors
has_related_synonym: nicotinamide mononucleotide synthetase inhibitor
has_related_synonym: nicotinamide mononucleotide synthetase inhibitors
has_related_synonym: nicotinamide phosphoribosyltransferase inhibitor
has_related_synonym: nicotinamide phosphoribosyltransferase inhibitors
has_related_synonym: nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase inhibitor
has_related_synonym: nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase inhibitors
id: CHEBI:231708
in subset: 3 STAR

BET bromodomain inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of BET proteins.
imported from: chebi.owl
has cross-reference: Wikipedia:BET_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: BET bromodomain inhibitors
has_related_synonym: BET inhibitor
has_related_synonym: BET inhibitors
has_related_synonym: Bromo- and Extra-Terminal domain inhibitor
has_related_synonym: Bromo- and Extra-Terminal domain inhibitors
id: CHEBI:231729
in subset: 3 STAR

CXCR2 antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that blocks CXCR2.
imported from: chebi.owl
has cross-reference: PMID:35313168
has cross-reference: PMID:36780833
has cross-reference: Wikipedia:Interleukin_8_receptor,_beta
has_obo_namespace: chebi_ontology
has_related_synonym: CXCR2 antagonists
has_related_synonym: IL8RB antagonist
has_related_synonym: IL8RB antagonists
has_related_synonym: chemokine receptor CXCR2 antagonist
has_related_synonym: chemokine receptor CXCR2 antagonists
has_related_synonym: interleukin 8 receptor, beta antagonist
has_related_synonym: interleukin 8 receptor, beta antagonists
id: CHEBI:231732
in subset: 3 STAR

EC 1.3.1.6 (fumarate reductase (NADH)) inhibitor
type: Class
subclass of: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of fumarate reductase (NADH) (EC 1.3.1.6).
imported from: chebi.owl
has cross-reference: Wikipedia:Fumarate_reductase_(NADH)
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.1.6 (fumarate reductase (NADH)) inhibitors
has_related_synonym: EC 1.3.1.6 inhibitor
has_related_synonym: EC 1.3.1.6 inhibitors
has_related_synonym: NADH-dependent fumarate reductase inhibitor
has_related_synonym: NADH-dependent fumarate reductase inhibitors
has_related_synonym: NADH-fumarate reductase inhibitor
has_related_synonym: NADH-fumarate reductase inhibitors
has_related_synonym: fumarate reductase (NADH) inhibitor
has_related_synonym: fumarate reductase (NADH) inhibitors
id: CHEBI:231760
in subset: 3 STAR

convulsant
type: Class
subclass of: central nervous system drug
textual definition: A drug that induces seizures or increases their severity.
imported from: chebi.owl
has cross-reference: Wikipedia:Convulsant
has_obo_namespace: chebi_ontology
has_related_synonym: convulsants
has_related_synonym: convulsive agent
has_related_synonym: convulsive agents
has_related_synonym: convulsive drug
has_related_synonym: convulsive drugs
id: CHEBI:231761
in subset: 3 STAR

renoprotective agent
type: Class
subclass of: protective agent
textual definition: Any compound that is able to prevent damage to the kidneys.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: renoprotective agents
has_related_synonym: renoprotector
id: CHEBI:231911
in subset: 3 STAR

NLRP3 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of NLRP3.
imported from: chebi.owl
has cross-reference: Wikipedia:NLRP3
has_obo_namespace: chebi_ontology
has_related_synonym: NACHT, LRR and PYD domains-containing protein 3 inhibitor
has_related_synonym: NACHT, LRR and PYD domains-containing protein 3 inhibitors
has_related_synonym: NALP3 inhibitor
has_related_synonym: NALP3 inhibitors
has_related_synonym: NLR family pyrin domain containing 3 inhibitor
has_related_synonym: NLR family pyrin domain containing 3 inhibitors
has_related_synonym: NLRP3 inhibitors
has_related_synonym: PYPAF1 inhibitor
has_related_synonym: PYPAF1 inhibitors
has_related_synonym: PYRIN-containing APAF1-like protein 1 inhibitor
has_related_synonym: PYRIN-containing APAF1-like protein 1 inhibitors
id: CHEBI:231916
in subset: 3 STAR

alpha-bungarotoxin
type: Class
subclass of: toxin
imported from: chebi.owl
charge: 0
formula: C50H70O14
inchi: InChI=1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-/t26-,28+,29-,30+,31+,32+,33+,34-,35+,36-,37+,38-,39+,40-,41-,42-,44-,45-,46+,47-,48+,49+,50+/m1/s1
inchikey: LYTCVQQGCSNFJU-LKGYBJPKSA-N
mass: 895.096
monoisotopicmass: 894.47656
has cross-reference: CAS:11032-79-4
alternative_term: 2-[[(1R,3S,5R,7S,9R,11S,12S,14S,16R,18S,20R,21Z,24S,26R,28S,30R,31R,33S,35R,37S,42R,44S,46R,48S)-12-hydroxy-1,3,11,24,31,41,44-heptamethyl-39-oxo-2,6,10,15,19,25,29,34,38,43,47-undecaoxaundecacyclo[26.22.0.03,26.05,24.07,20.09,18.011,16.030,48.033,46.035,44.037,42]pentaconta-21,40-dien-14-yl]methyl]prop-2-enal
alternative_term: alpha-bungarotoxin
has_obo_namespace: chebi_ontology
id: CHEBI:232110
in subset: 2 STAR

desnitro-imidacloprid
type: Class
subclass of: neonicotinoid insectide
imported from: chebi.owl
charge: 0
formula: C9H11ClN4
inchi: InChI=1S/C9H11ClN4/c10-8-2-1-7(5-13-8)6-14-4-3-12-9(14)11/h1-2,5H,3-4,6H2,(H2,11,12)
inchikey: UEQZFAGVRGWPDK-UHFFFAOYSA-N
mass: 210.670
monoisotopicmass: 210.06722
smiles: C1=CC(Cl)=NC=C1CN2CCNC2=N
has cross-reference: CAS:115970-17-7
has cross-reference: Wikipedia:https://en.wikipedia.org/wiki/Desnitro-imidacloprid
alternative_term: 1-[(6-chloropyridin-3-yl)methyl]-4,5-dihydroimidazol-2-amine
has_obo_namespace: chebi_ontology
id: CHEBI:232298
in subset: 2 STAR

heptacosa-7,11-diene
type: Class
subclass of: pheromone
imported from: chebi.owl
charge: 0
formula: C27H52
inchikey: RJYQFYALHBHYMG-IDQXUSCUSA-N
mass: 376.713
monoisotopicmass: 376.40690
smiles: CCCCCC/C=C/CC/C=C/CCCCCCCCCCCCCCC
has_obo_namespace: chebi_ontology
has_related_synonym: 7,11-heptacosadiene
id: CHEBI:232301
in subset: 2 STAR

AR-9281
type: Class
subclass of: enzyme inhibitor
imported from: chebi.owl
charge: 0
formula: C18H29N3O2
inchi: InChI=1S/C18H29N3O2/c1-12(22)21-4-2-16(3-5-21)19-17(23)20-18-9-13-6-14(10-18)8-15(7-13)11-18/h13-16H,2-11H2,1H3,(H2,19,20,23)
inchikey: HUDQLWBKJOMXSZ-UHFFFAOYSA-N
mass: 319.449
monoisotopicmass: 319.22598
has cross-reference: CAS:913548-29-5
has cross-reference: HMDB:HMDB0259461
alternative_term: 1-(1-acetylpiperidin-4-yl)-3-(1-adamantyl)urea
has_obo_namespace: chebi_ontology
has_related_synonym: APAU
id: CHEBI:232302
in subset: 2 STAR

KPT-350
type: Class
subclass of: exportin 1 inhibitor
imported from: chebi.owl
charge: 0
formula: C18H17F6N5O2
inchi: InChI=1S/C18H17F6N5O2/c1-16(2,3)15(31)27-26-13(30)4-5-29-9-25-14(28-29)10-6-11(17(19,20)21)8-12(7-10)18(22,23)24/h4-9H,1-3H3,(H,26,30)(H,27,31)/b5-4+
inchikey: BGUKCLNXSXSYCZ-SNAWJCMRSA-N
mass: 449.357
monoisotopicmass: 449.12864
has cross-reference: CAS:1487117-71-4
alternative_term: N'-[3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoyl]-2,2-dimethylpropanehydrazide
has_obo_namespace: chebi_ontology
id: CHEBI:232303
in subset: 2 STAR

CP-115953
type: Class
subclass of: topoisomerase inhibitor
imported from: chebi.owl
charge: 0
formula: C19H13F2NO4
inchi: InChI=1S/C19H13F2NO4/c20-14-7-12-17(16(21)15(14)9-1-5-11(23)6-2-9)22(10-3-4-10)8-13(18(12)24)19(25)26/h1-2,5-8,10,23H,3-4H2,(H,25,26)
inchikey: ISQTYKAFNUVODK-UHFFFAOYSA-N
mass: 357.313
monoisotopicmass: 357.08126
has cross-reference: CAS:136440-70-5
alternative_term: 1-cyclopropyl-6,8-difluoro-7-(4-hydroxyphenyl)-4-oxoquinoline-3-carboxylic acid
has_obo_namespace: chebi_ontology
id: CHEBI:232313
in subset: 2 STAR

bathophenanthrolinedisulfonic acid disodium salt
type: Class
subclass of: iron chelator
imported from: chebi.owl
charge: 0
formula: C24H14N2O6S2.H2O.Na.Na
inchi: InChI=1S/C24H16N2O6S2.2Na.H2O/c27-33(28,29)19-13-25-23-17(21(19)15-7-3-1-4-8-15)11-12-18-22(16-9-5-2-6-10-16)20(34(30,31)32)14-26-24(18)23;;;/h1-14H,(H,27,28,29)(H,30,31,32);;;1H2/q;2*+1;/p-2
inchikey: XYCFSBXROICZOX-UHFFFAOYSA-L
mass: 554.500
monoisotopicmass: 554.01943
has cross-reference: CAS:98645-86-4
has_obo_namespace: chebi_ontology
has_related_synonym: bathophenanthrolinedisulfonic acid disodium salt hydrate
id: CHEBI:232316
in subset: 2 STAR

DUB-IN-2
type: Class
subclass of: EC 3.4.19.* (omega-peptidase) inhibitor
imported from: chebi.owl
charge: 0
formula: C15H9N5O
inchi: InChI=1S/C15H9N5O/c1-2-21-20-14-10-6-4-3-5-9(10)13-15(14)19-12(8-17)11(7-16)18-13/h3-6H,2H2,1H3/b20-14+
inchikey: VKVAJBRQGBRHIK-XSFVSMFZSA-N
mass: 275.271
monoisotopicmass: 275.08071
smiles: CCO/N=C/1\C2=CC=CC=C2C3=C1N=C(C#N)C(C#N)=N3
has cross-reference: CAS:924296-19-5
has_obo_namespace: chebi_ontology
has_related_synonym: deubiquitinase inhibitor 2
id: CHEBI:232317
in subset: 2 STAR

benzoquinonium dibromide
type: Class
subclass of: cholinergic antagonist
imported from: chebi.owl
charge: 0
formula: C34H48N4O2.BrH.BrH
inchi: InChI=1S/C34H48N4O2.2BrH/c1-5-37(6-2,27-29-17-11-9-12-18-29)23-15-21-35-31-25-34(40)32(26-33(31)39)36-22-16-24-38(7-3,8-4)28-30-19-13-10-14-20-30;;/h9-14,17-20,25-26H,5-8,15-16,21-24,27-28H2,1-4H3;2*1H
inchikey: DVQZHWAYOLXTHE-UHFFFAOYSA-N
mass: 706.608
monoisotopicmass: 704.23005
smiles: CC[N+](CC)(CCC[N-]C1=CC(C(=CC1=O)[N-]CCC[N+](CC)(CC)CC2=CC=CC=C2)=O)CC3=CC=CC=C3.Br.Br
has cross-reference: PMID:31102763
alternative_term: benzyl-[3-[[4-[3-[benzyl(diethyl)azaniumyl]propylamino]-3,6-dioxocyclohexa-1,4-dien-1-yl]amino]propyl]-diethylazanium;dibromide
has_obo_namespace: chebi_ontology
id: CHEBI:232337
in subset: 2 STAR

methyllycaconitine citrate
type: Class
subclass of: nicotinic antagonist
imported from: chebi.owl
charge: 0
formula: C37H50N2O10.C6H8O7
inchi: InChI=1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33?,34-,35+,36-,37+;/m0./s1
inchikey: INBLZNJHDLEWPS-DDIMIZGISA-N
mass: 874.934
monoisotopicmass: 874.37355
has cross-reference: CAS:112825-05-5
has_obo_namespace: chebi_ontology
id: CHEBI:232340
in subset: 2 STAR

2-aminoethyl hydrogen sulfate
type: Class
subclass of: EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor
imported from: chebi.owl
charge: 0
formula: C2H7NO4S
inchi: InChI=1S/C2H7NO4S/c3-1-2-7-8(4,5)6/h1-3H2,(H,4,5,6)
inchikey: WSYUEVRAMDSJKL-UHFFFAOYSA-N
mass: 141.140
monoisotopicmass: 141.00958
smiles: C(COS(O)(=O)=O)N
has cross-reference: CAS:926-39-6
has cross-reference: PMID:31313987
has_obo_namespace: chebi_ontology
has_related_synonym: ethanolamine O-sulfate
id: CHEBI:232350
in subset: 2 STAR

(2-hept-2-ynylsulfanylphenyl) acetate
type: Class
subclass of: non-steroidal anti-inflammatory drug
imported from: chebi.owl
charge: 0
formula: C15H18O2S
inchi: InChI=1S/C15H18O2S/c1-3-4-5-6-9-12-18-15-11-8-7-10-14(15)17-13(2)16/h7-8,10-11H,3-5,12H2,1-2H3
inchikey: GXMBHQRROXQUJS-UHFFFAOYSA-N
mass: 262.370
monoisotopicmass: 262.10275
smiles: CCCCC#CCSC1=CC=CC=C1OC(C)=O
has cross-reference: CAS:209125-28-0
has cross-reference: PMID:26305987
has_obo_namespace: chebi_ontology
id: CHEBI:232352
in subset: 2 STAR

meperfluthrin
type: Class
subclass of: pyrethroid insecticide
imported from: chebi.owl
charge: 0
formula: C17H16Cl2F4O3
inchikey: MWFQAAWRPDRKDG-KOLCDFICSA-N
mass: 415.210
monoisotopicmass: 414.04126
has cross-reference: CAS:915288-13-0
has_obo_namespace: chebi_ontology
id: CHEBI:232355
in subset: 2 STAR

ML309
type: Class
subclass of: EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor
imported from: chebi.owl
charge: 0
formula: C29H29FN4O2
inchi: InChI=1S/C29H29FN4O2/c1-20-9-2-5-14-24(20)28(29(36)32-22-11-3-4-12-22)34(23-13-8-10-21(30)17-23)27(35)18-33-19-31-25-15-6-7-16-26(25)33/h2,5-10,13-17,19,22,28H,3-4,11-12,18H2,1H3,(H,32,36)
inchikey: GZLNOSRHZLTDMT-UHFFFAOYSA-N
mass: 484.575
monoisotopicmass: 484.22745
has cross-reference: PMID:32200800
alternative_term: 2-(N-[2-(benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclopentyl-2-(2-methylphenyl)acetamide
has_obo_namespace: chebi_ontology
id: CHEBI:232356
in subset: 2 STAR

tetrahydroindazole
type: Class
subclass of: EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor
imported from: chebi.owl
charge: 0
formula: C17H10BrCl4N5O2
inchikey: ONILAONOGQYBHW-UHFFFAOYSA-N
mass: 538.000
monoisotopicmass: 534.87720
has cross-reference: CAS:92332-99-5
has cross-reference: HMDB:HMDB0258900
has cross-reference: PMID:27428418
has_obo_namespace: chebi_ontology
id: CHEBI:232367
in subset: 2 STAR

3,4,5-tri-O-galloylquinic acid
type: Class
subclass of: DNA polymerase inhibitor
imported from: chebi.owl
charge: 0
formula: C28H24O18
inchi: InChI=1S/C28H24O18/c29-12-1-9(2-13(30)20(12)35)24(38)44-18-7-28(43,27(41)42)8-19(45-25(39)10-3-14(31)21(36)15(32)4-10)23(18)46-26(40)11-5-16(33)22(37)17(34)6-11/h1-6,18-19,23,29-37,43H,7-8H2,(H,41,42)/t18-,19-,23?,28?/m1/s1
inchikey: PEOHIPMSHPWYAQ-IOALSNHGSA-N
mass: 648.482
monoisotopicmass: 648.09626
has cross-reference: CAS:99745-62-7
has cross-reference: PMID:29406740
has cross-reference: Wikipedia:https://en.wikipedia.org/wiki/3,4,5-Tri-O-galloylquinic_acid
has_obo_namespace: chebi_ontology
id: CHEBI:232370
in subset: 2 STAR

SAR-AD81
type: Class
subclass of: protein kinase inhibitor
imported from: chebi.owl
charge: 0
formula: C34H41N3O8S
inchi: InChI=1S/C34H41N3O8S/c1-23(2)20-36(46(42,43)29-16-14-28(44-4)15-17-29)21-31(39)30(18-13-25-9-6-5-7-10-25)35-33(40)32-22-37(34(41)45-32)27-12-8-11-26(19-27)24(3)38/h5-12,14-17,19,23,30-32,39H,13,18,20-22H2,1-4H3,(H,35,40)/t30-,31+,32-/m0/s1
inchikey: NWOVALISMAROAW-QAXCHELISA-N
mass: 651.780
monoisotopicmass: 651.26144
has cross-reference: PMID:27626672
has_obo_namespace: chebi_ontology
id: CHEBI:232374
in subset: 2 STAR

3-aminopropyl(methyl)phosphinic acid
type: Class
subclass of: GABA agonist
imported from: chebi.owl
charge: 0
formula: C4H12NO2P
inchi: InChI=1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)
inchikey: NHVRIDDXGZPJTJ-UHFFFAOYSA-N
mass: 137.119
monoisotopicmass: 137.06057
smiles: CP(CCCN)(O)=O
has cross-reference: CAS:127729-35-5
has_obo_namespace: chebi_ontology
has_related_synonym: 3-APMPA
has_related_synonym: SKF-97541
id: CHEBI:232376
in subset: 2 STAR

CGP-54626
type: Class
subclass of: GABA antagonist
imported from: chebi.owl
charge: 0
formula: C18H28Cl2NO3P
inchikey: JGGVBBYJRQOPPA-BBRMVZONSA-N
mass: 408.300
monoisotopicmass: 407.11839
alternative_term: cyclohexylmethyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid
has_obo_namespace: chebi_ontology
id: CHEBI:232377
in subset: 2 STAR

triflumezopyrim
type: Class
subclass of: insecticide
imported from: chebi.owl
charge: 0
formula: C20H13F3N4O2
inchi: InChI=1S/C20H13F3N4O2/c21-20(22,23)15-5-3-4-14(8-15)17-18(28)26-7-2-1-6-16(26)27(19(17)29)11-13-9-24-12-25-10-13/h1-10,12H,11H2
inchikey: LHZOTJOOBRODLL-UHFFFAOYSA-N
mass: 398.345
monoisotopicmass: 398.09906
has cross-reference: CAS:1263133-33-0
has cross-reference: PMID:27130855
has_obo_namespace: chebi_ontology
id: CHEBI:232379
in subset: 2 STAR

GNE-3511
type: Class
subclass of: inhibitor
imported from: chebi.owl
charge: 0
formula: C23H26F2N6O
inchi: InChI=1S/C23H26F2N6O/c24-23(25)4-8-31(15-23)22-11-18(17-2-6-30(7-3-17)19-13-32-14-19)10-21(29-22)28-20-9-16(12-26)1-5-27-20/h1,5,9-11,17,19H,2-4,6-8,13-15H2,(H,27,28,29)
inchikey: RHFIAUKMKYHHFA-UHFFFAOYSA-N
mass: 440.499
monoisotopicmass: 440.21362
has cross-reference: PMID:25341110
alternative_term: 2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
has_obo_namespace: chebi_ontology
id: CHEBI:232381
in subset: 2 STAR

BIX-01294 trihydrochloride
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
imported from: chebi.owl
charge: 0
formula: C28H38N6O2.ClH.ClH.ClH
inchi: InChI=1S/C28H38N6O2.3ClH/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H
inchikey: FMURUEPQXKJIPS-UHFFFAOYSA-N
mass: 600.030
monoisotopicmass: 598.23566
smiles: CN1CCCN(CC1)C2=NC3=CC(=C(C=C3/C(=N/C4CCN(CC4)CC5=CC=CC=C5)/N2)OC)OC.Cl.Cl.Cl
has cross-reference: CAS:1392399-03-9
has_obo_namespace: chebi_ontology
has_related_synonym: BIX 01294 trihydrochloride
id: CHEBI:232399
in subset: 2 STAR

chromophore
type: Class
subclass of: photochemical role
textual definition: The part (atom or group of atoms) of a molecular entity in which the electronic transition responsible for a given spectral band is approximately localized.
imported from: chebi.owl
has cross-reference: Wikipedia:Chromophore
alternative_term: chromophore
has_obo_namespace: chebi_ontology
has_related_synonym: chromophores
id: CHEBI:23240
in subset: 3 STAR

N-methyl-4-phenylpyridinium iodide
type: Class
subclass of: mitochondrial NADH:ubiquinone reductase inhibitor
imported from: chebi.owl
charge: 0
formula: C12H12N.I
inchi: InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
inchikey: RFDFRDXIIKROAI-UHFFFAOYSA-M
mass: 297.139
monoisotopicmass: 297.00144
smiles: C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]
has cross-reference: CAS:36913-39-0
has cross-reference: PMID:20483372
has_obo_namespace: chebi_ontology
id: CHEBI:232401
in subset: 2 STAR

eeyarestatin I
type: Class
subclass of: inhibitor
imported from: chebi.owl
charge: 0
formula: C27H25Cl2N7O7
inchikey: JTUXTPWYZXWOIB-LWWHHIEBSA-N
mass: 630.440
monoisotopicmass: 629.11925
has cross-reference: CAS:412960-54-4
has cross-reference: PMID:20865169
has_obo_namespace: chebi_ontology
has_related_synonym: eeyarestatin 1
id: CHEBI:232402
in subset: 2 STAR

ammonium tetrathiomolybdate
type: Class
subclass of: copper chelator
imported from: chebi.owl
charge: 0
formula: H10MoN2S4
inchi: InChI=1S/Mo.2H3N.2H2S.2S/h;2*1H3;2*1H2;;
inchikey: ZKKLPDLKUGTPME-UHFFFAOYSA-N
mass: 262.288
monoisotopicmass: 263.87809
smiles: [Mo].N.N.S.S.[S].[S]
has cross-reference: CAS:15060-55-6
has cross-reference: PMID:18775584
has_obo_namespace: chebi_ontology
id: CHEBI:232403
in subset: 2 STAR

haedoxan
type: Class
subclass of: pesticide
imported from: chebi.owl
charge: 0
formula: C33H34O14
inchi: InChI=1S/C33H34O14/c1-35-12-26-27(16-5-6-19-21(7-16)42-14-41-19)46-23-9-20(36-2)17(8-22(23)45-26)28-18-11-39-32(33(18,34)13-40-28)47-30-24(37-3)10-25-29(31(30)38-4)44-15-43-25/h5-10,18,26-28,32,34H,11-15H2,1-4H3/t18-,26-,27-,28-,32-,33-/m1/s1
inchikey: SVQIUEXUTJVJTM-KTIWSMOXSA-N
mass: 654.621
monoisotopicmass: 654.19486
has cross-reference: CAS:123619-26-1
has_obo_namespace: chebi_ontology
has_related_synonym: haedoxan A
id: CHEBI:232406
in subset: 2 STAR

racemetirosine
type: Class
subclass of: EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor
imported from: chebi.owl
charge: 0
formula: C10H13NO3
inchi: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)
inchikey: NHTGHBARYWONDQ-UHFFFAOYSA-N
mass: 195.218
monoisotopicmass: 195.08954
smiles: CC(CC1=CC=C(C=C1)O)(C(=O)O)N
has cross-reference: CAS:658-48-0
has cross-reference: HMDB:HMDB0247174
has cross-reference: PMID:28900300
has_obo_namespace: chebi_ontology
has_related_synonym: alpha-methyl-p-tyrosine
id: CHEBI:232408
in subset: 2 STAR

WAY-100635 maleate
type: Class
subclass of: serotonergic antagonist
imported from: chebi.owl
charge: 0
formula: C25H34N4O2.C4H4O4
inchi: InChI=1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
inchikey: XIGAHNVCEFUYOV-WLHGVMLRSA-N
mass: 538.645
monoisotopicmass: 538.27913
has cross-reference: PMID:21818550
has_obo_namespace: chebi_ontology
has_related_synonym: WAY100635
id: CHEBI:232409
in subset: 2 STAR

EHT 1864
type: Class
subclass of: EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor
imported from: chebi.owl
charge: 0
formula: C25H27F3N2O4S.ClH.ClH
inchikey: LSECOAJFCKFQJG-UHFFFAOYSA-N
mass: 581.470
monoisotopicmass: 580.11772
has cross-reference: CAS:754240-09-0
has cross-reference: PMID:35976098
alternative_term: 2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one;dihydrochloride
has_obo_namespace: chebi_ontology
has_related_synonym: 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
id: CHEBI:232411
in subset: 2 STAR

VU041
type: Class
subclass of: potassium channel blocker
imported from: chebi.owl
charge: 0
formula: C19H20F3N3O
inchi: InChI=1S/C19H20F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h1,3,6,9H,2,4-5,7-8,10-12H2
inchikey: DLAGRCZUELSZFG-UHFFFAOYSA-N
mass: 363.384
monoisotopicmass: 363.15585
has cross-reference: PMID:29371678
has_obo_namespace: chebi_ontology
id: CHEBI:232413
in subset: 2 STAR

EGTA acetoxymethyl ester
type: Class
subclass of: chelator
imported from: chebi.owl
charge: 0
formula: C26H40N2O18
inchi: InChI=1S/C26H40N2O18/c1-19(29)39-15-43-23(33)11-27(12-24(34)44-16-40-20(2)30)5-7-37-9-10-38-8-6-28(13-25(35)45-17-41-21(3)31)14-26(36)46-18-42-22(4)32/h5-18H2,1-4H3
inchikey: GNJXVFXIDHCCKR-UHFFFAOYSA-N
mass: 668.602
monoisotopicmass: 668.22761
has cross-reference: CAS:99590-86-0
has cross-reference: PMID:30102150
has_obo_namespace: chebi_ontology
has_related_synonym: EGTA-AM
id: CHEBI:232417
in subset: 2 STAR

dexpramipexole
type: Class
subclass of: dopamine agonist
imported from: chebi.owl
charge: 0
formula: C10H17N3S
inchi: InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m1/s1
inchikey: FASDKYOPVNHBLU-SSDOTTSWSA-N
mass: 211.330
monoisotopicmass: 211.11432
smiles: CCCN[C@@]1(CCC2=C(C1)SC(=N)N2)[H]
has cross-reference: CAS:104632-28-2
has cross-reference: KEGG:D09886
has cross-reference: Wikipedia:https://en.wikipedia.org/wiki/Dexpramipexole
has_obo_namespace: chebi_ontology
id: CHEBI:232420
in subset: 2 STAR

MitoTEMPO
type: Class
subclass of: radical scavenger
imported from: chebi.owl
charge: 0
formula: C29H35ClN2O2P
inchi: InChI=1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H
inchikey: WKKFJIJNGHNQQW-UHFFFAOYSA-N
mass: 510.028
monoisotopicmass: 509.21247
smiles: CC1(C)CC(CC(C)(C)N1[O])\N=C(\C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)/[O-].Cl
has cross-reference: PMID:29213118
has_obo_namespace: chebi_ontology
has_related_synonym: Mito-TEMPO
id: CHEBI:232424
in subset: 2 STAR

calcium chelator
type: Class
subclass of: chelator
textual definition: A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central calcium atom at two or more points.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: calcium chelating agent
has_related_synonym: calcium chelating agents
has_related_synonym: calcium chelators
id: CHEBI:232436
in subset: 3 STAR

p53 inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor of tumour protein p53.
imported from: chebi.owl
has cross-reference: PMID:31310659
has cross-reference: Wikipedia:P53
has_obo_namespace: chebi_ontology
has_related_synonym: cellular tumor antigen p53 inhibitor
has_related_synonym: cellular tumor antigen p53 inhibitors
has_related_synonym: p53 inhibitors
has_related_synonym: phosphoprotein p53 inhibitor
has_related_synonym: phosphoprotein p53 inhibitors
has_related_synonym: tumor protein p53 inhibitor
has_related_synonym: tumor protein p53 inhibitors
has_related_synonym: tumour protein p53 inhibitor
has_related_synonym: tumour protein p53 inhibitors
has_related_synonym: tumour suppressor p53 inhibitor
has_related_synonym: tumour suppressor p53 inhibitors
id: CHEBI:232442
in subset: 3 STAR

mass spectrometer degradation product
type: Class
subclass of: chemical role
textual definition: Any product obtained as a result of mass spectrometer degradation.
imported from: chebi.owl
charge: 0
mass: 0.000
monoisotopicmass: 0.00000
has_obo_namespace: chebi_ontology
id: CHEBI:232530
in subset: 2 STAR

saredutant
type: Class
subclass of: antagonist
imported from: chebi.owl
charge: 0
formula: C31H35Cl2N3O2
inchikey: PGKXDIMONUAMFR-AREMUKBSSA-N
mass: 552.536
monoisotopicmass: 551.21063
has cross-reference: CAS:142001-63-6
has cross-reference: DrugBank:DB06660
has cross-reference: PMID:38057665
has cross-reference: Wikipedia:https://en.wikipedia.org/wiki/Saredutant
alternative_term: N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
has_obo_namespace: chebi_ontology
has_related_synonym: SR 48968
id: CHEBI:233291
in subset: 2 STAR

AK-1
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
imported from: chebi.owl
charge: 0
formula: C19H21N3O5S
inchi: InChI=1S/C19H21N3O5S/c23-19(20-16-8-6-9-17(14-16)22(24)25)15-7-5-10-18(13-15)28(26,27)21-11-3-1-2-4-12-21/h5-10,13-14H,1-4,11-12H2,(H,20,23)
inchikey: HAYBKCHPEBZNGW-UHFFFAOYSA-N
mass: 403.46000000000004
monoisotopicmass: 403.1201917719999
has cross-reference: PMID:20378838
alternative_term: 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide
has_obo_namespace: chebi_ontology
id: CHEBI:233328
in subset: 2 STAR

P2Y14 receptor antagonist
type: Class
subclass of: G-protein-coupled receptor antagonist
textual definition: An antagonist at the P2Y14 receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:P2RY14
has_obo_namespace: chebi_ontology
has_related_synonym: BPR105 anatgonist
has_related_synonym: BPR105 antagonists
has_related_synonym: G protein-coupled receptor 105 antagonist
has_related_synonym: G protein-coupled receptor 105 antagonists
has_related_synonym: GPR105 antagonist
has_related_synonym: GPR105 antagonists
has_related_synonym: KIAA0001 antagonist
has_related_synonym: KIAA0001 antagonists
has_related_synonym: P2RY14 antagonist
has_related_synonym: P2RY14 antagonists
has_related_synonym: P2Y purinoceptor 14 antagonist
has_related_synonym: P2Y purinoceptor 14 antagonists
has_related_synonym: P2Y14 antagonist
has_related_synonym: P2Y14 antagonists
has_related_synonym: P2Y14 receptor antagonists
has_related_synonym: P2Y14R antagonist
has_related_synonym: P2Y14R antagonists
has_related_synonym: purinergic receptor P2Y14 antagonist
has_related_synonym: purinergic receptor P2Y14 antagonists
id: CHEBI:233336
in subset: 3 STAR

EC 1.14.11.68 ([histone H3]-trimethyl-L-lysine(27) demethylase) inhibitor
type: Class
subclass of: EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor
textual definition: An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.11.68 ([histone H3]-trimethyl-L-lysine(27) demethylase) inhibitors
has_related_synonym: EC 1.14.11.68 inhibitor
has_related_synonym: EC 1.14.11.68 inhibitors
has_related_synonym: JMJD3 inhibitor
has_related_synonym: JMJD3 inhibitors
has_related_synonym: KDM6A inhibitor
has_related_synonym: KDM6A inhibitors
has_related_synonym: KDM6C inhibitor
has_related_synonym: KDM6C inhibitors
has_related_synonym: UTX inhibitor
has_related_synonym: UTX inhibitors
has_related_synonym: UTY inhibitor
has_related_synonym: UTY inhibitors
has_related_synonym: [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine-27,2-oxoglutarate:oxygen oxidoreductase inhibitor
has_related_synonym: [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine-27,2-oxoglutarate:oxygen oxidoreductase inhibitors
has_related_synonym: [histone H3]-trimethyl-L-lysine(27) demethylase inhibitor
has_related_synonym: [histone H3]-trimethyl-L-lysine(27) demethylase inhibitors
id: CHEBI:233404
in subset: 3 STAR

antifibrotic agent
type: Class
subclass of: drug
textual definition: Any agent which acts to reduce fibrosis.
imported from: chebi.owl
has cross-reference: Wikipedia:Fibrosis
has_obo_namespace: chebi_ontology
has_related_synonym: anti-fibrotic agent
has_related_synonym: anti-fibrotic agents
has_related_synonym: antifibrosis agent
has_related_synonym: antifibrosis agents
has_related_synonym: antifibrotic agents
has_related_synonym: antifibrotic drug
has_related_synonym: antifibrotic drugs
id: CHEBI:233423
in subset: 3 STAR

chemosensitiser
type: Class
subclass of: biological role
textual definition: Any compound that can sensitise tumour cells to chemotherapy.
imported from: chebi.owl
has cross-reference: Wikipedia:Chemosensitizer
has_obo_namespace: chebi_ontology
has_related_synonym: chemosensitisers
has_related_synonym: chemosensitising agent
has_related_synonym: chemosensitising agents
has_related_synonym: chemosensitizer
has_related_synonym: chemosensitizers
has_related_synonym: chemosensitizing agent
has_related_synonym: chemosensitizing agents
id: CHEBI:233442
in subset: 3 STAR

coenzyme
type: Class
subclass of: cofactor
textual definition: A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons.
imported from: chebi.owl
alternative_term: coenzyme
has_obo_namespace: chebi_ontology
has_related_synonym: coenzymes
id: CHEBI:23354
in subset: 3 STAR

cofactor
type: Class
subclass of: biochemical role
textual definition: An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
imported from: chebi.owl
has cross-reference: Wikipedia:Cofactor_(biochemistry)
alternative_term: cofactor
alternative_term: cofactors
has_obo_namespace: chebi_ontology
id: CHEBI:23357
in subset: 3 STAR

asoxime chloride
type: Class
subclass of: cholinesterase reactivator
imported from: chebi.owl
charge: 0
formula: C14H14N4O3.HCl.HCl
inchi: InChI=1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H/b13-9+;;
inchikey: QELSIJXWEROXOE-IGUOPLJTSA-N
mass: 359.213
monoisotopicmass: 358.05995
smiles: Cl.Cl.O=NC=C1C=CC=CN1COC[N+]2=CC=C(C=C2)C(=O)[NH-]
has cross-reference: CAS:34433-31-3
has cross-reference: PMID:39292449
has cross-reference: Wikipedia:https://en.wikipedia.org/wiki/Asoxime_chloride
alternative_term: 1-[[2-(hydroxyiminomethyl)pyridin-1-ium-1-yl]methoxymethyl]pyridin-1-ium-4-carboxamide;dichloride
has_obo_namespace: chebi_ontology
has_related_synonym: HI-6
id: CHEBI:233581
in subset: 2 STAR

compatible osmolytes
type: Class
subclass of: osmolyte
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:23366
in subset: 1 STAR

molecular entity
type: Class
subclass of: chemical entity
textual definition: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
imported from: chebi.owl
alternative_term: molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: entidad molecular
has_related_synonym: entidades moleculares
has_related_synonym: entite moleculaire
has_related_synonym: molecular entities
has_related_synonym: molekulare Entitaet
id: CHEBI:23367
in subset: 3 STAR

5a,20a-tetrahydroprogesterone
type: Class
subclass of: biological role
imported from: chebi.owl
charge: 0
formula: C21H34O2
inchi: InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h13-14,16-19,22H,4-12H2,1-3H3
inchikey: DYVGYXXLXQESJE-UHFFFAOYSA-N
mass: 318.501
monoisotopicmass: 318.25588
has cross-reference: PMID:2292213
alternative_term: 1-(1-hydroxyethyl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-one
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(1-hydroxyethyl)-9a,11a-dimethyl-tetradecahydrocyclopenta[a]phenanthren-7-one
id: CHEBI:233713
in subset: 2 STAR

17a-hydroxy-5a-pregnane-3,20-dione
type: Class
subclass of: biological role
imported from: chebi.owl
charge: 0
formula: C21H32O3
inchi: InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h14,16-18,24H,4-12H2,1-3H3
inchikey: UUOHXXXJRQGPLC-UHFFFAOYSA-N
mass: 332.484
monoisotopicmass: 332.23514
has cross-reference: PMID:2292213
alternative_term: 1-acetyl-1-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-one
has_obo_namespace: chebi_ontology
has_related_synonym: 1-acetyl-1-hydroxy-9a,11a-dimethyl-dodecahydro-2H-cyclopenta[a]phenanthren-7-one
id: CHEBI:233714
in subset: 2 STAR

EC 3.2.1.169 (protein O-GlcNAcase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of protein O-GlcNAcase (EC 3.2.1.169).
imported from: chebi.owl
has cross-reference: Wikipedia:Protein_O-GlcNAcase
has_obo_namespace: chebi_ontology
has_related_synonym: BtGH84 inhibitor
has_related_synonym: BtGH84 inhibitors
has_related_synonym: EC 3.2.1.169 (protein O-GlcNAcase) inhibitors
has_related_synonym: EC 3.2.1.169 inhibitor
has_related_synonym: EC 3.2.1.169 inhibitors
has_related_synonym: O-GlcNAc hydrolase inhibitor
has_related_synonym: O-GlcNAc hydrolase inhibitors
has_related_synonym: O-GlcNAcase inhibitor
has_related_synonym: O-GlcNAcase inhibitors
has_related_synonym: OGA inhibitor
has_related_synonym: OGA inhibitors
has_related_synonym: [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase inhibitor
has_related_synonym: [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase inhibitors
has_related_synonym: glycoside hydrolase O-GlcNAcase inhibitor
has_related_synonym: glycoside hydrolase O-GlcNAcase inhibitors
has_related_synonym: protein O-GlcNAcase inhibitor
has_related_synonym: protein O-GlcNAcase inhibitors
id: CHEBI:234036
in subset: 3 STAR

OLIG2 inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor of OLIG2.
imported from: chebi.owl
has cross-reference: Wikipedia:OLIG2
has_obo_namespace: chebi_ontology
has_related_synonym: BHLHB1 inhibitor
has_related_synonym: BHLHB1 inhibitors
has_related_synonym: OLIG2 inhibitors
has_related_synonym: OLIGO2 inhibitor
has_related_synonym: OLIGO2 inhibitors
has_related_synonym: PRKCBP2 inhibitor
has_related_synonym: PRKCBP2 inhibitors
has_related_synonym: RACK17 inhibitor
has_related_synonym: RACK17 inhibitors
has_related_synonym: bHLHe19 inhibitor
has_related_synonym: bHLHe19 inhibitors
has_related_synonym: oligodendrocyte lineage transcription factor 2 inhibitor
has_related_synonym: oligodendrocyte lineage transcription factor 2 inhibitors
has_related_synonym: oligodendrocyte transcription factor 2 inhibitor
has_related_synonym: oligodendrocyte transcription factor 2 inhibitors
has_related_synonym: oligodendrocyte transcription factor inhibitor
has_related_synonym: oligodendrocyte transcription factor inhibitors
id: CHEBI:234089
in subset: 3 STAR

Double stranded DNA
type: Class
subclass of: biological role
textual definition: Double-stranded DNA from Xenopus laevis
imported from: chebi.owl
has cross-reference: PMID:12079350
has_obo_namespace: chebi_ontology
id: CHEBI:234102
in subset: 2 STAR

cytochrome-b6f complex inhibitor
type: Class
subclass of: photosynthetic electron-transport chain inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:23529
in subset: 1 STAR

cytokinin
type: Class
subclass of: plant hormone
textual definition: A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.
imported from: chebi.owl
has cross-reference: Wikipedia:Cytokinin
has_obo_namespace: chebi_ontology
id: CHEBI:23530
in subset: 3 STAR

defoliant
type: Class
subclass of: herbicide
textual definition: A herbicide which when sprayed or dusted on plants causes its leaves to fall off.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Defoliationsmittel
has_related_synonym: Entlaubungsmittel
has_related_synonym: defoliants
id: CHEBI:23582
in subset: 3 STAR

drug
type: Class
subclass of: pharmaceutical
textual definition: Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: drugs
has_related_synonym: medicine
id: CHEBI:23888
in subset: 3 STAR

ecdysone antagonists
type: Class
subclass of: insect growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:23891
in subset: 1 STAR

enzyme inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
imported from: chebi.owl
alternative_term: enzyme inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: enzyme inhibitors
has_related_synonym: inhibidor enzimatico
has_related_synonym: inhibidores enzimaticos
has_related_synonym: inhibiteur enzymatique
has_related_synonym: inhibiteurs enzymatiques
id: CHEBI:23924
in subset: 3 STAR

estradiol
type: Class
subclass of: molecular entity
textual definition: A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17.
imported from: chebi.owl
charge: 0
formula: C18H24O2
inchi: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17?,18+/m1/s1
inchikey: VOXZDWNPVJITMN-WKUFJEKOSA-N
mass: 272.38196
monoisotopicmass: 272.17763
has_alternative_id: CHEBI:42364
has cross-reference: PMID:10696569
has cross-reference: PMID:24084694
has cross-reference: Wikipedia:Estradiol
alternative_term: estra-1,3,5(10)-triene-3,17-diol
has_obo_namespace: chebi_ontology
has_related_synonym: oestradiol
id: CHEBI:23965
in subset: 3 STAR

ethylene releasers
type: Class
subclass of: plant growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24002
in subset: 1 STAR

fat-soluble vitamin (role)
type: Class
subclass of: vitamin (role)
textual definition: Any vitamin that dissolves in fats and are stored in body tissues. Unlike the water-soluble vitamins, they are stored in the body for long periods of time and generally pose a greater risk for toxicity when consumed in excess.
imported from: chebi.owl
has cross-reference: PMID:31838543
has cross-reference: PMID:32057251
has cross-reference: PMID:33549284
has cross-reference: PMID:34045883
has_obo_namespace: chebi_ontology
has_related_synonym: fat-soluble vitamin
has_related_synonym: fat-soluble vitamins
has_related_synonym: fettloesliche Vitamine
id: CHEBI:24020
in subset: 3 STAR

iron(3+) chelator
type: Class
subclass of: iron chelator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24028
in subset: 1 STAR

fungicide
type: Class
subclass of: pesticide
subclass of: antifungal agent
textual definition: A substance used to destroy fungal pests.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fungicides
id: CHEBI:24127
in subset: 3 STAR

EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
type: Class
subclass of: EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
textual definition: An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Glutamine_synthetase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors
has_related_synonym: EC 6.3.1.2 inhibitor
has_related_synonym: EC 6.3.1.2 inhibitors
has_related_synonym: L-glutamate:ammonia ligase (ADP-forming) inhibitor
has_related_synonym: L-glutamate:ammonia ligase (ADP-forming) inhibitors
has_related_synonym: L-glutamine synthetase inhibitor
has_related_synonym: L-glutamine synthetase inhibitors
has_related_synonym: glutamate--ammonia ligase (EC 6.3.1.2) inhibitor
has_related_synonym: glutamate--ammonia ligase (EC 6.3.1.2) inhibitors
has_related_synonym: glutamate--ammonia ligase inhibitor
has_related_synonym: glutamate--ammonia ligase inhibitors
has_related_synonym: glutamine synthetase inhibitor
has_related_synonym: glutamine synthetase inhibitors
has_related_synonym: glutamylhydroxamic synthetase inhibitor
has_related_synonym: glutamylhydroxamic synthetase inhibitors
id: CHEBI:24319
in subset: 3 STAR

group transfer coenzymes
type: Class
subclass of: coenzyme
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24430
in subset: 1 STAR

chemical entity
type: Class
subclass of: BAO_0003116
textual definition: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
imported from: chebi.owl
alternative_term: chemical entity
has_obo_namespace: chebi_ontology
id: CHEBI:24431
in subset: 3 STAR

biological role
type: Class
subclass of: BAO_0002929
textual definition: A role played by the molecular entity or part thereof within a biological context.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: biological function
id: CHEBI:24432
in subset: 3 STAR

herbicide
type: Class
subclass of: pesticide
textual definition: A substance used to destroy plant pests.
imported from: chebi.owl
has cross-reference: Wikipedia:Herbicide
has_obo_namespace: chebi_ontology
has_related_synonym: Herbizid
has_related_synonym: Unkrautbekaempfungsmittel
has_related_synonym: Unkrautvertilgungsmittel
has_related_synonym: Wildkrautbekaempfungsmittel
has_related_synonym: herbicides
id: CHEBI:24527
in subset: 3 STAR

hormone
type: Class
subclass of: molecular messenger
subclass of: agonist
textual definition: Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: endocrine
has_related_synonym: hormones
id: CHEBI:24621
in subset: 3 STAR

insect attractant
type: Class
subclass of: biological role
textual definition: A chemical that attracts insects.
imported from: chebi.owl
has cross-reference: PMID:7044287
has_obo_namespace: chebi_ontology
has_related_synonym: insect attractants
id: CHEBI:24850
in subset: 3 STAR

insect growth regulator
type: Class
subclass of: insecticide
subclass of: growth regulator
textual definition: A growth regulator that inhibits the life cycle of an insect.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: insect growth regulators
id: CHEBI:24851
in subset: 3 STAR

insecticide
type: Class
subclass of: pesticide
textual definition: Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.
imported from: chebi.owl
has cross-reference: Wikipedia:Insecticide
has_obo_namespace: chebi_ontology
has_related_synonym: insecticides
id: CHEBI:24852
in subset: 3 STAR

intercalator
type: Class
subclass of: mutagen
textual definition: A role played by a chemical agent which exhibits the capability of occupying space between DNA base pairs due to particular properties in size, shape and charge. Intercalation of chemical compounds in DNA helix can result in replication errors (shift, mutation) or DNA damages.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: agente intercalante
has_related_synonym: intercalating agent
has_related_synonym: intercalating agents
has_related_synonym: intercalating ligands
has_related_synonym: intercalators
id: CHEBI:24853
in subset: 3 STAR

ionophore
type: Class
subclass of: membrane transport modulator
textual definition: A compound which can carry specific ions through membranes of cells or organelles.
imported from: chebi.owl
has cross-reference: Wikipedia:Ionophore
alternative_term: ionophore
has_obo_namespace: chebi_ontology
has_related_synonym: ionophores
id: CHEBI:24869
in subset: 3 STAR

iron ionophore
type: Class
subclass of: ionophore
textual definition: Any ionophore capable of transportation of iron ions across membranes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: iron ionophores
id: CHEBI:24874
in subset: 3 STAR

jasmonates
type: Class
subclass of: plant hormone
textual definition: The jasmonates (JAs) are a group of plant hormones which help regulate plant growth and development.
imported from: chebi.owl
has cross-reference: Wikipedia:Jasmonate
has_obo_namespace: chebi_ontology
id: CHEBI:24937
in subset: 3 STAR

juvenile hormone antagonists
type: Class
subclass of: insect growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24941
in subset: 1 STAR

juvenile hormone mimic
type: Class
subclass of: insect growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24942
in subset: 1 STAR

luciferin
type: Class
subclass of: photobiochemical role
textual definition: A low-molecular-mass compound present in bioluminescent organisms that emits light when oxidized in presence of enzyme luciferase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:25078
in subset: 3 STAR

metabolite
type: Class
subclass of: biochemical role
textual definition: Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
imported from: chebi.owl
has_alternative_id: CHEBI:26619
has_alternative_id: CHEBI:35220
alternative_term: metabolite
has_obo_namespace: chebi_ontology
has_related_synonym: metabolites
has_related_synonym: primary metabolites
has_related_synonym: secondary metabolites
id: CHEBI:25212
in subset: 3 STAR

mitochondrial respiratory-chain inhibitor
type: Class
subclass of: respiratory-chain inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mitochondrial electron transport chain inhibitors
has_related_synonym: mitochondrial electron-transport chain inhibitor
has_related_synonym: mitochondrial respiratory chain inhibitors
id: CHEBI:25355
in subset: 3 STAR

mutagen
type: Class
subclass of: genotoxin
textual definition: An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
imported from: chebi.owl
has cross-reference: Wikipedia:Mutagen
has_obo_namespace: chebi_ontology
has_related_synonym: mutagene
has_related_synonym: mutagenes
has_related_synonym: mutagenic agent
has_related_synonym: mutageno
has_related_synonym: mutagenos
has_related_synonym: mutagens
id: CHEBI:25435
in subset: 3 STAR

mycotoxin
type: Class
subclass of: toxin
subclass of: fungal metabolite
textual definition: Poisonous substance produced by fungi.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fungal toxins
has_related_synonym: mycotoxins
id: CHEBI:25442
in subset: 3 STAR

nematicide
type: Class
subclass of: pesticide
textual definition: A substance used to destroy pests of the phylum Nematoda (roundworms).
imported from: chebi.owl
has cross-reference: Wikipedia:Nematicide
has_obo_namespace: chebi_ontology
has_related_synonym: nematicides
has_related_synonym: nematocide
has_related_synonym: nematocides
id: CHEBI:25491
in subset: 3 STAR

neurotransmitter
type: Class
subclass of: molecular messenger
textual definition: An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.
imported from: chebi.owl
has cross-reference: Wikipedia:Neurotransmitter
has_obo_namespace: chebi_ontology
has_related_synonym: neurotransmitters
id: CHEBI:25512
in subset: 3 STAR

neonicotinoid insectide
type: Class
subclass of: insecticide
subclass of: nicotinic acetylcholine receptor agonist
subclass of: neurotoxin
textual definition: A class of neuro-active insecticides that act at the nicotinic acetylcholine receptor.
imported from: chebi.owl
has_alternative_id: CHEBI:25498
has cross-reference: Wikipedia:Neonicotinoid
has_obo_namespace: chebi_ontology
has_related_synonym: neonicotinoid insectides
has_related_synonym: nicotinoid insectide
has_related_synonym: nicotinoid insectides
id: CHEBI:25540
in subset: 3 STAR

nodulation factor
type: Class
subclass of: biological role
textual definition: A role played by signal molecules produced by the symbiotic bacteria that trigger nodule formation (typically on the host plant roots).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NF
has_related_synonym: nod factor
has_related_synonym: nodulation factors
id: CHEBI:25573
in subset: 3 STAR

nucleoside antibiotic
type: Class
subclass of: antimicrobial agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:25605
in subset: 1 STAR

osmolyte
type: Class
subclass of: biological role
textual definition: A solute used by a cell under water stress to maintain cell volume.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: osmolytes
id: CHEBI:25728
in subset: 3 STAR

oxidized luciferins
type: Class
subclass of: luciferin
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:25747
in subset: 1 STAR

pesticide synergist
type: Class
subclass of: pesticide
textual definition: A substance that increases the efficacy of a pesticide.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pesticide synergists
id: CHEBI:25943
in subset: 3 STAR

pesticide
type: Class
subclass of: application
textual definition: Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.
imported from: chebi.owl
has cross-reference: Wikipedia:Pesticide
alternative_term: pesticide
has_obo_namespace: chebi_ontology
has_related_synonym: Pestizid
has_related_synonym: Pestizide
has_related_synonym: pesticides
id: CHEBI:25944
in subset: 3 STAR

pheromone
type: Class
subclass of: semiochemical
textual definition: A semiochemical used in olfactory communication between organisms of the same species eliciting a change in sexual or social behaviour.
imported from: chebi.owl
has cross-reference: PMID:23988175
has cross-reference: Wikipedia:Pheromone
alternative_term: pheromone
has_obo_namespace: chebi_ontology
has_related_synonym: ectohormone
has_related_synonym: feromone
has_related_synonym: pheromones
id: CHEBI:26013
in subset: 3 STAR

phosphorus containing antibiotics
type: Class
subclass of: aliphatic antibiotics
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26083
in subset: 1 STAR

photosynthetic electron-transport chain inhibitor
type: Class
subclass of: herbicide
subclass of: electron-transport chain inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26087
in subset: 1 STAR

photosystem-I inhibitor
type: Class
subclass of: photosynthetic electron-transport chain inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26088
in subset: 1 STAR

photosystem-II inhibitor
type: Class
subclass of: photosynthetic electron-transport chain inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26089
in subset: 1 STAR

phytoalexin
type: Class
subclass of: phytotoxin
textual definition: A toxin made by a plant that acts against an organism attacking it.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phytoalexins
id: CHEBI:26115
in subset: 3 STAR

biological pigment
type: Class
subclass of: biophysical role
textual definition: An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pigments
id: CHEBI:26130
in subset: 3 STAR

plant growth regulator
type: Class
subclass of: growth regulator
textual definition: A chemical, natural or artificial, that can affect the rate of growth of a plant.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: plant growth regulators
id: CHEBI:26155
in subset: 3 STAR

plant growth stimulator
type: Class
subclass of: plant growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: plant growth stimulators
id: CHEBI:26157
in subset: 3 STAR

precocenes
type: Class
subclass of: juvenile hormone antagonists
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26220
in subset: 1 STAR

prosthetic group
type: Class
subclass of: cofactor
textual definition: A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity.
imported from: chebi.owl
alternative_term: prosthetic group
has_obo_namespace: chebi_ontology
has_related_synonym: groupe prosthetique
has_related_synonym: prosthetic groups
id: CHEBI:26348
in subset: 3 STAR

pyrethroid insecticide
type: Class
subclass of: insecticide
subclass of: sodium channel modulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pyrethroid insecticides
id: CHEBI:26413
in subset: 3 STAR

semiochemical
type: Class
subclass of: molecular messenger
textual definition: A molecular messenger released by an organism that affects the behaviour within or between species.
imported from: chebi.owl
has cross-reference: Wikipedia:Semiochemical
has_obo_namespace: chebi_ontology
has_related_synonym: semiochemicals
id: CHEBI:26645
in subset: 3 STAR

sideramine
type: Class
subclass of: siderophore
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26671
in subset: 1 STAR

siderophore
type: Class
subclass of: cofactor
subclass of: iron(3+) chelator
subclass of: iron ionophore
textual definition: Any of low-molecular-mass iron(III)-chelating compounds produced by microorganisms for the purpose of the transport and sequestration of iron.
imported from: chebi.owl
alternative_term: siderophore
has_obo_namespace: chebi_ontology
has_related_synonym: ferrioxamine
has_related_synonym: ferrioxamines
has_related_synonym: ironophore
has_related_synonym: siderochrome
has_related_synonym: siderochromes
has_related_synonym: siderophores
id: CHEBI:26672
in subset: 3 STAR

amodiaquine
type: Class
subclass of: molecular entity
textual definition: A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.
imported from: chebi.owl
charge: 0
formula: C20H22ClN3O
inchi: InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)
inchikey: OVCDSSHSILBFBN-UHFFFAOYSA-N
mass: 355.86100
monoisotopicmass: 355.14514
smiles: CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O
has cross-reference: CAS:86-42-0
has cross-reference: DrugBank:DB00613
has cross-reference: Drug_Central:186
has cross-reference: KEGG:C07626
has cross-reference: KEGG:D02922
has cross-reference: LINCS:LSM-4042
has cross-reference: PDBeChem:CQA
has cross-reference: PMID:11044276
has cross-reference: PMID:11971651
has cross-reference: PMID:17046445
has cross-reference: PMID:17222819
has cross-reference: PMID:18419816
has cross-reference: PMID:18855526
has cross-reference: PMID:19024339
has cross-reference: PMID:19245687
has cross-reference: PMID:26206402
has cross-reference: PMID:26597254
has cross-reference: PMID:26647924
has cross-reference: PMID:26735991
has cross-reference: PMID:26851641
has cross-reference: PMID:26900802
has cross-reference: PMID:26930583
has cross-reference: PMID:27031231
has cross-reference: PMID:8885219
has cross-reference: Patent:US2474821
has cross-reference: Reaxys:300962
has cross-reference: Wikipedia:Amodiaquine
alternative_term: 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
alternative_term: Amodiaquine
has_obo_namespace: chebi_ontology
has_related_synonym: amodiaquina
has_related_synonym: amodiaquine
has_related_synonym: amodiaquinum
id: CHEBI:2674
in subset: 3 STAR

synthetic auxin
type: Class
subclass of: auxin
subclass of: xenobiotic
textual definition: A synthetic compound exhibiting auxin activity.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: synthetic auxins
id: CHEBI:26841
in subset: 3 STAR

systemic acquired resistance inducing compounds
type: Class
subclass of: xenobiotic
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26842
in subset: 1 STAR

toxin
type: Class
subclass of: metabolite
subclass of: poison
textual definition: Poisonous substance produced by a biological organism such as a microbe, animal or plant.
imported from: chebi.owl
has cross-reference: Wikipedia:Toxin
alternative_term: toxin
has_obo_namespace: chebi_ontology
has_related_synonym: toxins
id: CHEBI:27026
in subset: 3 STAR

micronutrient
type: Class
subclass of: nutrient
textual definition: Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
imported from: chebi.owl
has cross-reference: Wikipedia:Micronutrient
has_obo_namespace: chebi_ontology
has_related_synonym: micronutrients
has_related_synonym: trace elements
id: CHEBI:27027
in subset: 3 STAR

volatile oil component
type: Class
subclass of: biochemical role
subclass of: plant metabolite
textual definition: Any plant metabolite that is found naturally as a component of a volatile oil.
imported from: chebi.owl
has cross-reference: Wikipedia:Essential_oil
has_obo_namespace: chebi_ontology
has_related_synonym: essential oil component
has_related_synonym: essential oil components
has_related_synonym: ethereal oil component
has_related_synonym: ethereal oil components
has_related_synonym: volatile oil components
id: CHEBI:27311
in subset: 3 STAR

water-soluble vitamin (role)
type: Class
subclass of: vitamin (role)
textual definition: Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: wasserloesliche Vitamine
has_related_synonym: water-soluble vitamin
has_related_synonym: water-soluble vitamins
id: CHEBI:27314
in subset: 3 STAR

xenobiotic organic ethers
type: Class
subclass of: xenobiotic
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:27334
in subset: 1 STAR

detergent
type: Class
subclass of: application
subclass of: surfactant
textual definition: A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions.
imported from: chebi.owl
has_alternative_id: CHEBI:23648
has_alternative_id: CHEBI:4456
has cross-reference: KEGG:C01689
alternative_term: detergent
has_obo_namespace: chebi_ontology
has_related_synonym: Detergents
id: CHEBI:27780
in subset: 3 STAR

quinidine
type: Class
subclass of: molecular entity
textual definition: A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.
imported from: chebi.owl
charge: 0
formula: C20H24N2O2
inchi: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
inchikey: LOUPRKONTZGTKE-LHHVKLHASA-N
mass: 324.41680
monoisotopicmass: 324.18378
has_alternative_id: CHEBI:127150
has_alternative_id: CHEBI:26494
has_alternative_id: CHEBI:355477
has_alternative_id: CHEBI:529982
has_alternative_id: CHEBI:595841
has_alternative_id: CHEBI:597286
has_alternative_id: CHEBI:604323
has_alternative_id: CHEBI:8719
has cross-reference: CAS:56-54-2
has cross-reference: DrugBank:DB00908
has cross-reference: Drug_Central:2346
has cross-reference: KEGG:C06527
has cross-reference: KEGG:D08458
has cross-reference: LINCS:LSM-3325
has cross-reference: PMID:12477351
has cross-reference: PMID:12699389
has cross-reference: PMID:14971904
has cross-reference: PMID:14973303
has cross-reference: PMID:15089813
has cross-reference: PMID:15225721
has cross-reference: PMID:15270556
has cross-reference: PMID:15328252
has cross-reference: PMID:16570918
has cross-reference: PMID:17132069
has cross-reference: PMID:17228875
has cross-reference: PMID:17249648
has cross-reference: PMID:17870541
has cross-reference: PMID:18324762
has cross-reference: PMID:18395298
has cross-reference: PMID:18788725
has cross-reference: PMID:23861085
has cross-reference: PMID:24130427
has cross-reference: PMID:445303
has cross-reference: PMID:8337232
has cross-reference: PMID:9864343
has cross-reference: Reaxys:91866
alternative_term: (9S)-6'-methoxycinchonan-9-ol
alternative_term: Quinidine
alternative_term: quinidine
has_obo_namespace: chebi_ontology
has_related_synonym: (+)-Quinidine
has_related_synonym: (+)-quinidine
has_related_synonym: (8R,9S)-quinidine
has_related_synonym: (R)-(6-methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol
has_related_synonym: (S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
has_related_synonym: (S)-(6-methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol
has_related_synonym: 6-methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
has_related_synonym: CIN-QUIN
has_related_synonym: Chinidin
has_related_synonym: Conchinin
has_related_synonym: Kinidin
has_related_synonym: alpha-(6-methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol
has_related_synonym: beta-quinine
has_related_synonym: chinidinum
has_related_synonym: conquinine
has_related_synonym: pitayine
has_related_synonym: quinidina
id: CHEBI:28593
in subset: 3 STAR

bupropion
type: Class
subclass of: molecular entity
textual definition: An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.
imported from: chebi.owl
charge: 0
formula: C13H18ClNO
inchi: InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
inchikey: SNPPWIUOZRMYNY-UHFFFAOYSA-N
mass: 239.74086
monoisotopicmass: 239.10769
smiles: CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1
has cross-reference: CAS:34841-39-9
has cross-reference: CAS:34911-55-2
has cross-reference: DrugBank:DB01156
has cross-reference: Drug_Central:435
has cross-reference: HMDB:HMDB0001510
has cross-reference: KEGG:C06860
has cross-reference: KEGG:D07591
has cross-reference: LINCS:LSM-1267
has cross-reference: MetaCyc:CPD-3481
has cross-reference: PMID:12826985
has cross-reference: PMID:15876900
has cross-reference: Reaxys:2101062
has cross-reference: Wikipedia:Bupropion
alternative_term: 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
alternative_term: Bupropion
has_obo_namespace: chebi_ontology
id: CHEBI:3219
in subset: 3 STAR

vitamin (role)
type: Class
subclass of: micronutrient
subclass of: biochemical role
textual definition: A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term "vitamines" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines.
imported from: chebi.owl
has_alternative_id: CHEBI:10004
has_alternative_id: CHEBI:27305
has cross-reference: Wikipedia:Vitamin
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin
has_related_synonym: vitamina
has_related_synonym: vitaminas
has_related_synonym: vitamine
has_related_synonym: vitamines
has_related_synonym: vitamins
has_related_synonym: vitaminum
id: CHEBI:33229
in subset: 3 STAR

antitubercular agent
type: Class
subclass of: antimycobacterial drug
textual definition: A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antitubercular
has_related_synonym: antitubercular agents
has_related_synonym: antitubercular drug
has_related_synonym: antitubercular drugs
has_related_synonym: tuberculostatic agent
id: CHEBI:33231
in subset: 3 STAR

application
type: Class
subclass of: BAO_0002929
textual definition: Intended use of the molecular entity or part thereof by humans.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:33232
in subset: 3 STAR

atom
type: Class
subclass of: chemical entity
textual definition: A chemical entity constituting the smallest component of an element having the chemical properties of the element.
imported from: chebi.owl
has_alternative_id: CHEBI:22671
has_alternative_id: CHEBI:23907
alternative_term: atom
has_obo_namespace: chebi_ontology
has_related_synonym: atome
has_related_synonym: atomo
has_related_synonym: atoms
has_related_synonym: atomus
has_related_synonym: element
has_related_synonym: elements
id: CHEBI:33250
in subset: 3 STAR

molecular messenger
type: Class
subclass of: biological role
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: chemical messenger
id: CHEBI:33280
in subset: 3 STAR

antimicrobial agent
type: Class
subclass of: biological role
textual definition: A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
imported from: chebi.owl
has_alternative_id: CHEBI:22582
has cross-reference: PMID:12964249
has cross-reference: PMID:22117953
has cross-reference: PMID:22439833
has cross-reference: PMID:22849268
has cross-reference: PMID:22849276
has cross-reference: PMID:22958833
has_obo_namespace: chebi_ontology
has_related_synonym: Antibiotika
has_related_synonym: Antibiotikum
has_related_synonym: antibiotic
has_related_synonym: antibiotics
has_related_synonym: antibiotique
has_related_synonym: antimicrobial
has_related_synonym: antimicrobial agents
has_related_synonym: antimicrobials
has_related_synonym: microbicide
has_related_synonym: microbicides
id: CHEBI:33281
in subset: 3 STAR

antibacterial agent
type: Class
subclass of: antimicrobial agent
textual definition: A substance (or active part thereof) that kills or slows the growth of bacteria.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antibacterial agents
has_related_synonym: antibacterials
has_related_synonym: bactericide
has_related_synonym: bactericides
id: CHEBI:33282
in subset: 3 STAR

nutrient
type: Class
subclass of: food component
textual definition: A nutrient is a food component that an organism uses to survive and grow.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nutrients
id: CHEBI:33284
in subset: 3 STAR

agrochemical
type: Class
subclass of: application
textual definition: An agrochemical is a substance that is used in agriculture or horticulture.
imported from: chebi.owl
has cross-reference: Wikipedia:Agrochemical
has_obo_namespace: chebi_ontology
has_related_synonym: agrichemical
has_related_synonym: agrichemicals
has_related_synonym: agricultural chemicals
has_related_synonym: agrochemicals
id: CHEBI:33286
in subset: 3 STAR

fertilizer
type: Class
subclass of: agrochemical
textual definition: A fertilizer is any substance that is added to soil or water to assist the growth of plants.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fertiliser
has_related_synonym: fertilizers
id: CHEBI:33287
in subset: 3 STAR

rodenticide
type: Class
subclass of: pesticide
textual definition: A substance used to destroy rodent pests.
imported from: chebi.owl
has cross-reference: Wikipedia:Rodenticide
has_obo_namespace: chebi_ontology
has_related_synonym: rodenticides
id: CHEBI:33288
in subset: 3 STAR

avicide
type: Class
subclass of: pesticide
textual definition: A substance used to destroy bird pests (class Aves).
imported from: chebi.owl
has cross-reference: Wikipedia:Avicide
has_obo_namespace: chebi_ontology
has_related_synonym: avicides
id: CHEBI:33289
in subset: 3 STAR

food
type: Class
subclass of: physiological role
textual definition: A physiological role played by any substance of either plant, animal or artificial origin which contains essential body nutrients that can be ingested by an organism to provide energy, promote growth, and maintain the processes of life.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food material
has_related_synonym: food materials
has_related_synonym: food role
has_related_synonym: foods
has_related_synonym: foodstuff
has_related_synonym: foodstuffs
id: CHEBI:33290
in subset: 3 STAR

fuel
type: Class
subclass of: application
textual definition: An energy-rich substance that can be transformed with release of usable energy.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:33292
in subset: 3 STAR

diagnostic agent
type: Class
subclass of: pharmaceutical
textual definition: A substance administered to aid diagnosis of a disease.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: diagnostic aid
id: CHEBI:33295
in subset: 3 STAR

reagent
type: Class
subclass of: application
textual definition: A substance used in a chemical reaction to detect, measure, examine, or produce other substances.
imported from: chebi.owl
alternative_term: reagent
has_obo_namespace: chebi_ontology
has_related_synonym: reactif
has_related_synonym: reactivo
has_related_synonym: reagents
id: CHEBI:33893
in subset: 3 STAR

molluscicide
type: Class
subclass of: pesticide
textual definition: A substance used to destroy pests of the phylum Mollusca.
imported from: chebi.owl
has cross-reference: Wikipedia:Molluscicide
has_obo_namespace: chebi_ontology
has_related_synonym: molluscicides
id: CHEBI:33904
in subset: 3 STAR

macronutrient
type: Class
subclass of: nutrient
textual definition: Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: macronutrients
id: CHEBI:33937
in subset: 3 STAR

surfactant
type: Class
subclass of: emulsifier
textual definition: A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.
imported from: chebi.owl
alternative_term: surfactant
has_obo_namespace: chebi_ontology
has_related_synonym: surface active agent
has_related_synonym: surfactants
id: CHEBI:35195
in subset: 3 STAR

lumiphore
type: Class
subclass of: photochemical role
textual definition: A part of a molecular entity (atom or group of atoms) in which electronic excitation associated with a given emission band is approximately localized.
imported from: chebi.owl
alternative_term: lumiphore
has_obo_namespace: chebi_ontology
has_related_synonym: luminophore
id: CHEBI:35197
in subset: 3 STAR

tracer
type: Class
subclass of: application
textual definition: A role played by a foreign substance mixed with or attached to a given substance to enable the distribution or location of the latter to be determined subsequently.
imported from: chebi.owl
alternative_term: tracer
has_obo_namespace: chebi_ontology
id: CHEBI:35204
in subset: 3 STAR

chemical tracer
type: Class
subclass of: tracer
textual definition: A role played by a chemical compound with properties similar to those of the substance being traced with which it is mixed homogeneously.
imported from: chebi.owl
alternative_term: chemical tracer
has_obo_namespace: chebi_ontology
id: CHEBI:35205
in subset: 3 STAR

isotopic tracer
type: Class
subclass of: tracer
textual definition: A tracer which only differs in isotopic composition from the substance to be traced.
imported from: chebi.owl
alternative_term: isotopic tracer
has_obo_namespace: chebi_ontology
id: CHEBI:35206
in subset: 3 STAR

radioactive tracer
type: Class
subclass of: tracer
textual definition: A tracer containing a radioactive label.
imported from: chebi.owl
alternative_term: radioactive tracer
has_obo_namespace: chebi_ontology
id: CHEBI:35207
in subset: 3 STAR

physical tracer
type: Class
subclass of: tracer
textual definition: A physical tracer is one that is attached by physical means to the object being traced.
imported from: chebi.owl
alternative_term: physical tracer
has_obo_namespace: chebi_ontology
id: CHEBI:35208
in subset: 3 STAR

label
type: Class
subclass of: application
textual definition: A role played by a part of a molecular entity distinguishable by the observer but not by the system and used to identify a tracer.
imported from: chebi.owl
alternative_term: label
has_obo_namespace: chebi_ontology
id: CHEBI:35209
in subset: 3 STAR

spin label
type: Class
subclass of: label
textual definition: A role played by a stable paramagnetic group that is attached to a part of a molecular entity whose microscopic environment is of interest and may be revealed by the electron spin resonance (ESR) spectroscopy.
imported from: chebi.owl
alternative_term: spin label
has_obo_namespace: chebi_ontology
id: CHEBI:35210
in subset: 3 STAR

radioactive label
type: Class
subclass of: label
imported from: chebi.owl
alternative_term: radioactive label
has_obo_namespace: chebi_ontology
id: CHEBI:35211
in subset: 3 STAR

plant growth retardant
type: Class
subclass of: plant growth regulator
imported from: chebi.owl
has_alternative_id: CHEBI:26154
has_alternative_id: CHEBI:26156
has_obo_namespace: chebi_ontology
has_related_synonym: plant growth inhibitor
has_related_synonym: plant growth inhibitors
has_related_synonym: plant growth retardants
id: CHEBI:35219
in subset: 3 STAR

antimetabolite
type: Class
subclass of: biochemical role
textual definition: A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
imported from: chebi.owl
has cross-reference: Wikipedia:Antimetabolite
alternative_term: antimetabolite
has_obo_namespace: chebi_ontology
has_related_synonym: antimetabolites
id: CHEBI:35221
in subset: 3 STAR

inhibitor
type: Class
subclass of: biological role
textual definition: A substance that diminishes the rate of a chemical reaction.
imported from: chebi.owl
alternative_term: inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: inhibidor
has_related_synonym: inhibiteur
has_related_synonym: inhibitors
id: CHEBI:35222
in subset: 3 STAR

catalyst
type: Class
subclass of: chemical role
textual definition: A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.
imported from: chebi.owl
alternative_term: catalyst
has_obo_namespace: chebi_ontology
has_related_synonym: Katalysator
has_related_synonym: catalizador
has_related_synonym: catalyseur
id: CHEBI:35223
in subset: 3 STAR

effector
type: Class
subclass of: biochemical role
textual definition: A small molecule which increases (activator) or decreases (inhibitor) the activity of an (allosteric) enzyme by binding to the enzyme at the regulatory site (which is different from the substrate-binding catalytic site).
imported from: chebi.owl
has cross-reference: Wikipedia:Effector_(biology)
alternative_term: effector
has_obo_namespace: chebi_ontology
has_related_synonym: enzyme modulator
id: CHEBI:35224
in subset: 3 STAR

buffer
type: Class
subclass of: chemical role
textual definition: Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: buffer compound
has_related_synonym: buffer compounds
id: CHEBI:35225
in subset: 3 STAR

spin probe
type: Class
subclass of: probe
textual definition: A role played by a stable paramagnetic molecular entity used to study the microscopic environment by electron paramagnetic resonance (EPR) spectroscopy without covalent attachment to the molecular entity of interest.
imported from: chebi.owl
has cross-reference: Wikipedia:Spin_probe
alternative_term: spin probe
has_obo_namespace: chebi_ontology
id: CHEBI:35226
in subset: 3 STAR

fossil fuel
type: Class
subclass of: fuel
textual definition: A fuel such as coal, oil and natural gas which has formed over many years through the decomposition of deposited vegetation which was under extreme pressure of an overburden of earth.
imported from: chebi.owl
alternative_term: fossil fuel
has_obo_namespace: chebi_ontology
id: CHEBI:35230
in subset: 3 STAR

nuclear fuel
type: Class
subclass of: fuel
textual definition: Material containing fissile nuclides, which when placed in a reactor, enables a chain reaction to be achieved.
imported from: chebi.owl
alternative_term: nuclear fuel
has_obo_namespace: chebi_ontology
id: CHEBI:35231
in subset: 3 STAR

radiopharmaceutical
type: Class
subclass of: pharmaceutical
textual definition: Any pharmaceutical compound containing a radioisotope.
imported from: chebi.owl
has cross-reference: Wikipedia:Radiopharmaceutical
has_obo_namespace: chebi_ontology
has_related_synonym: radiopharmaceuticals
id: CHEBI:35232
in subset: 3 STAR

central nervous system stimulant
type: Class
subclass of: central nervous system drug
textual definition: Any drug that enhances the activity of the central nervous system.
imported from: chebi.owl
has cross-reference: Wikipedia:Central_nervous_system_stimulants
alternative_term: central nervous system stimulant
has_obo_namespace: chebi_ontology
has_related_synonym: CNS stimulant
has_related_synonym: analeptic
has_related_synonym: analeptic agent
has_related_synonym: analeptic drug
has_related_synonym: analeptics
has_related_synonym: central stimulant
id: CHEBI:35337
in subset: 3 STAR

antiinfective agent
type: Class
subclass of: drug
textual definition: A substance used in the prophylaxis or therapy of infectious diseases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-infective agents
has_related_synonym: anti-infective drugs
has_related_synonym: antiinfective agents
has_related_synonym: antiinfective drug
id: CHEBI:35441
in subset: 3 STAR

antiparasitic agent
type: Class
subclass of: antiinfective agent
textual definition: A substance used to treat or prevent parasitic infections.
imported from: chebi.owl
has cross-reference: Wikipedia:Antiparasitic
has_obo_namespace: chebi_ontology
has_related_synonym: antiparasitic drugs
has_related_synonym: antiparasitics
has_related_synonym: parasiticides
id: CHEBI:35442
in subset: 3 STAR

anthelminthic drug
type: Class
subclass of: antiparasitic agent
textual definition: Substance intended to kill parasitic worms (helminths).
imported from: chebi.owl
alternative_term: anthelminthic
has_obo_namespace: chebi_ontology
has_related_synonym: anthelminthics
has_related_synonym: anthelmintic
has_related_synonym: anthelmintics
has_related_synonym: antihelminth
has_related_synonym: antihelmintico
has_related_synonym: vermifuge
id: CHEBI:35443
in subset: 3 STAR

antinematodal drug
type: Class
subclass of: nematicide
subclass of: anthelminthic drug
textual definition: A substance used in the treatment or control of nematode infestations.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antinematodal agent
has_related_synonym: antinematodal drugs
has_related_synonym: antinematodals
id: CHEBI:35444
in subset: 3 STAR

EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
type: Class
subclass of: antihypertensive agent
subclass of: EC 3.4.15.* (peptidyl-dipeptidase) inhibitor
textual definition: An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1).
imported from: chebi.owl
has cross-reference: Wikipedia:ACE_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: ACE inhibitor
has_related_synonym: ACE inhibitors
has_related_synonym: DCP inhibitor
has_related_synonym: DCP inhibitors
has_related_synonym: EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitors
has_related_synonym: EC 3.4.15.1 inhibitor
has_related_synonym: EC 3.4.15.1 inhibitors
has_related_synonym: PDH inhibitor
has_related_synonym: PDH inhibitors
has_related_synonym: angiotensin I-converting enzyme inhibitor
has_related_synonym: angiotensin I-converting enzyme inhibitors
has_related_synonym: angiotensin-converting enzyme inhibitor
has_related_synonym: angiotensin-converting enzyme inhibitors
has_related_synonym: carboxycathepsin inhibitor
has_related_synonym: carboxycathepsin inhibitors
has_related_synonym: dipeptidase inhibitor
has_related_synonym: dipeptidase inhibitors
has_related_synonym: dipeptide hydrolase inhibitor
has_related_synonym: dipeptide hydrolase inhibitors
has_related_synonym: dipeptidyl carboxypeptidase I inhibitor
has_related_synonym: dipeptidyl carboxypeptidase I inhibitors
has_related_synonym: dipeptidyl carboxypeptidase inhibitor
has_related_synonym: dipeptidyl carboxypeptidase inhibitors
has_related_synonym: endothelial cell peptidyl dipeptidase inhibitor
has_related_synonym: endothelial cell peptidyl dipeptidase inhibitors
has_related_synonym: kininase II inhibitor
has_related_synonym: kininase II inhibitors
has_related_synonym: peptidase P inhibitor
has_related_synonym: peptidase P inhibitors
has_related_synonym: peptidyl dipeptidase A inhibitor
has_related_synonym: peptidyl dipeptidase A inhibitors
has_related_synonym: peptidyl dipeptidase I inhibitor
has_related_synonym: peptidyl dipeptidase I inhibitors
has_related_synonym: peptidyl dipeptidase-4 inhibitor
has_related_synonym: peptidyl dipeptidase-4 inhibitors
has_related_synonym: peptidyl dipeptide hydrolase inhibitor
has_related_synonym: peptidyl dipeptide hydrolase inhibitors
has_related_synonym: peptidyl-dipeptidase A (EC 3.4.15.1) inhibitor
has_related_synonym: peptidyl-dipeptidase A (EC 3.4.15.1) inhibitors
has_related_synonym: peptidyl-dipeptidase A inhibitor
has_related_synonym: peptidyl-dipeptidase A inhibitors
has_related_synonym: peptidyl-dipeptide hydrolase inhibitor
has_related_synonym: peptidyl-dipeptide hydrolase inhibitors
has_related_synonym: peptidyldipeptide hydrolase inhibitor
has_related_synonym: peptidyldipeptide hydrolase inhibitors
id: CHEBI:35457
in subset: 3 STAR

antidepressant
type: Class
subclass of: psychotropic drug
textual definition: Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidepressant drugs
has_related_synonym: antidepressants
has_related_synonym: thymoanaleptics
has_related_synonym: thymoleptic drugs
has_related_synonym: thymoleptics
id: CHEBI:35469
in subset: 3 STAR

central nervous system drug
type: Class
subclass of: drug
textual definition: A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CNS agent
has_related_synonym: CNS drugs
has_related_synonym: central nervous system agents
id: CHEBI:35470
in subset: 3 STAR

psychotropic drug
type: Class
subclass of: central nervous system drug
textual definition: A loosely defined grouping of drugs that have effects on psychological function.
imported from: chebi.owl
has cross-reference: Wikipedia:Psychotropic_drug
has_obo_namespace: chebi_ontology
has_related_synonym: psychoactive agent
has_related_synonym: psychoactive drugs
has_related_synonym: psychopharmaceuticals
has_related_synonym: psychotropic drugs
id: CHEBI:35471
in subset: 3 STAR

anti-inflammatory drug
type: Class
subclass of: drug
subclass of: anti-inflammatory agent
textual definition: A substance that reduces or suppresses inflammation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-inflammatory drugs
has_related_synonym: antiinflammatory agent
has_related_synonym: antiinflammatory drug
has_related_synonym: antiinflammatory drugs
id: CHEBI:35472
in subset: 3 STAR

tranquilizing drug
type: Class
subclass of: psychotropic drug
subclass of: central nervous system depressant
textual definition: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ataractics
has_related_synonym: tranquilising drug
has_related_synonym: tranquilizing drugs
has_related_synonym: tranquillising agent
has_related_synonym: tranquillizing agents
id: CHEBI:35473
in subset: 3 STAR

anxiolytic drug
type: Class
subclass of: tranquilizing drug
textual definition: Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-anxiety agents
has_related_synonym: anti-anxiety drugs
has_related_synonym: anxiolytic agents
has_related_synonym: anxiolytics
has_related_synonym: minor tranquilisers
has_related_synonym: minor tranquilizers
has_related_synonym: minor tranquilizing agents
id: CHEBI:35474
in subset: 3 STAR

non-steroidal anti-inflammatory drug
type: Class
subclass of: anti-inflammatory drug
subclass of: antirheumatic drug
textual definition: An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
imported from: chebi.owl
has cross-reference: Wikipedia:Non-steroidal_anti-inflammatory_drug
has_obo_namespace: chebi_ontology
has_related_synonym: NSAID
has_related_synonym: NSAIDs
has_related_synonym: non-steroidal anti-inflammatory agent
has_related_synonym: non-steroidal anti-inflammatory drugs
id: CHEBI:35475
in subset: 3 STAR

antipsychotic agent
type: Class
subclass of: tranquilizing drug
textual definition: Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Neuroleptikum
has_related_synonym: antipsychotic agents
has_related_synonym: antipsychotic drug
has_related_synonym: antipsychotic drugs
has_related_synonym: antipsychotics
has_related_synonym: antipsychotiques
has_related_synonym: grosser Tranquilizer
has_related_synonym: major tranquilizers
has_related_synonym: major tranquilizing agents
has_related_synonym: neuroleptic
has_related_synonym: neuroleptic agents
has_related_synonym: neuroleptics
has_related_synonym: neuroleptique
has_related_synonym: neuroleptiques
id: CHEBI:35476
in subset: 3 STAR

antimanic drug
type: Class
subclass of: tranquilizing drug
textual definition: Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antimanic agent
has_related_synonym: antimanic drugs
has_related_synonym: antimanics
id: CHEBI:35477
in subset: 3 STAR

analgesic
type: Class
subclass of: drug
subclass of: pharmacological role
textual definition: An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:35480
in subset: 3 STAR

non-narcotic analgesic
type: Class
subclass of: analgesic
textual definition: A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:35481
in subset: 3 STAR

opioid analgesic
type: Class
subclass of: analgesic
textual definition: A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: narcotic
has_related_synonym: narcotic analgesic
has_related_synonym: narcotic analgesics
has_related_synonym: narcotics
has_related_synonym: opioid analgesics
id: CHEBI:35482
in subset: 3 STAR

EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
type: Class
subclass of: EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of aldehyde dehydrogenase (NAD(+)), EC 1.2.1.3.
imported from: chebi.owl
has cross-reference: Wikipedia:Aldehyde_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: CoA-independent aldehyde dehydrogenase inhibitor
has_related_synonym: CoA-independent aldehyde dehydrogenase inhibitors
has_related_synonym: EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitor
has_related_synonym: EC 1.2.1.3 (aldehyde dehydrogenase (NAD(+))) inhibitors
has_related_synonym: EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitors
has_related_synonym: EC 1.2.1.3 inhibitor
has_related_synonym: EC 1.2.1.3 inhibitors
has_related_synonym: NAD-aldehyde dehydrogenase inhibitor
has_related_synonym: NAD-aldehyde dehydrogenase inhibitors
has_related_synonym: NAD-dependent 4-hydroxynonenal dehydrogenase inhibitor
has_related_synonym: NAD-dependent 4-hydroxynonenal dehydrogenase inhibitors
has_related_synonym: NAD-dependent aldehyde dehydrogenase inhibitor
has_related_synonym: NAD-dependent aldehyde dehydrogenase inhibitors
has_related_synonym: NAD-linked aldehyde dehydrogenase inhibitor
has_related_synonym: NAD-linked aldehyde dehydrogenase inhibitors
has_related_synonym: aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitor
has_related_synonym: aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) inhibitors
has_related_synonym: aldehyde dehydrogenase (NAD(+)) inhibitor
has_related_synonym: aldehyde dehydrogenase (NAD(+)) inhibitors
has_related_synonym: aldehyde dehydrogenase (NAD) inhibitor
has_related_synonym: aldehyde dehydrogenase (NAD) inhibitors
has_related_synonym: aldehyde dehydrogenase inhibitor
has_related_synonym: aldehyde dehydrogenase inhibitors
has_related_synonym: m-methylbenzaldehyde dehydrogenase inhibitor
has_related_synonym: m-methylbenzaldehyde dehydrogenase inhibitors
has_related_synonym: propionaldehyde dehydrogenase inhibitor
has_related_synonym: propionaldehyde dehydrogenase inhibitors
id: CHEBI:35487
in subset: 3 STAR

central nervous system depressant
type: Class
subclass of: central nervous system drug
textual definition: A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CNS depressants
has_related_synonym: central nervous system depressants
id: CHEBI:35488
in subset: 3 STAR

antipyretic
type: Class
subclass of: drug
textual definition: A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
imported from: chebi.owl
has cross-reference: Wikipedia:Antipyretic
has_obo_namespace: chebi_ontology
has_related_synonym: anti-pyretic
id: CHEBI:35493
in subset: 3 STAR

androgen antagonist
type: Class
subclass of: hormone antagonist
textual definition: A compound which inhibits or antagonises the biosynthesis or actions of androgens.
imported from: chebi.owl
has cross-reference: Wikipedia:Antiandrogen
has_obo_namespace: chebi_ontology
has_related_synonym: antiandrogen
id: CHEBI:35497
in subset: 3 STAR

diuretic
type: Class
subclass of: drug
textual definition: An agent that promotes the excretion of urine through its effects on kidney function.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: diuretics
id: CHEBI:35498
in subset: 3 STAR

hallucinogen
type: Class
subclass of: psychotropic drug
textual definition: Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hallucinogenic agents
has_related_synonym: hallucinogenic drugs
has_related_synonym: hallucinogens
has_related_synonym: psychedelic agents
has_related_synonym: psychedelics
id: CHEBI:35499
in subset: 3 STAR

beta-adrenergic agonist
type: Class
subclass of: adrenergic agonist
subclass of: beta-adrenergic drug
textual definition: An agent that selectively binds to and activates beta-adrenergic receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: beta-adrenergic agonists
has_related_synonym: beta-adrenergic receptor agonist
has_related_synonym: beta-adrenoceptor agonists
id: CHEBI:35522
in subset: 3 STAR

bronchodilator agent
type: Class
subclass of: drug
textual definition: An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bronchodilator
has_related_synonym: bronchodilator agents
has_related_synonym: broncholytic agent
id: CHEBI:35523
in subset: 3 STAR

sympathomimetic agent
type: Class
subclass of: adrenergic agent
textual definition: A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sympathomimetic
has_related_synonym: sympathomimetics
id: CHEBI:35524
in subset: 3 STAR

hypoglycemic agent
type: Class
subclass of: drug
textual definition: A drug which lowers the blood glucose level.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-hyperglycemic agent
has_related_synonym: anti-hyperglycemic agents
has_related_synonym: antidiabetic
has_related_synonym: antihyperglycemic
has_related_synonym: antihyperglycemic agent
has_related_synonym: antihyperglycemic agents
has_related_synonym: antihyperglycemic drug
has_related_synonym: antihyperglycemic drugs
has_related_synonym: antihyperglycemics
has_related_synonym: hypoglycemic agents
has_related_synonym: hypoglycemic drug
has_related_synonym: hypoglycemic drugs
id: CHEBI:35526
in subset: 3 STAR

beta-adrenergic antagonist
type: Class
subclass of: adrenergic antagonist
subclass of: beta-adrenergic drug
textual definition: An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: beta-adrenergic antagonists
has_related_synonym: beta-adrenergic blocker
has_related_synonym: beta-adrenergic blockers
has_related_synonym: beta-adrenergic receptor blockaders
has_related_synonym: beta-adrenoceptor antagonists
has_related_synonym: beta-blocker
has_related_synonym: beta-blockers
id: CHEBI:35530
in subset: 3 STAR

EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
type: Class
subclass of: EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor
has_related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors
has_related_synonym: (PG)H synthase inhibitor
has_related_synonym: (PG)H synthase inhibitors
has_related_synonym: COX inhibitor
has_related_synonym: EC 1.14.99.1 (cyclooxygenase) inhibitor
has_related_synonym: EC 1.14.99.1 (cyclooxygenase) inhibitors
has_related_synonym: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors
has_related_synonym: EC 1.14.99.1 inhibitor
has_related_synonym: EC 1.14.99.1 inhibitors
has_related_synonym: PG synthetase inhibitor
has_related_synonym: PG synthetase inhibitors
has_related_synonym: cyclooxygenase (EC 1.14.99.1) inhibitor
has_related_synonym: cyclooxygenase (EC 1.14.99.1) inhibitors
has_related_synonym: cyclooxygenase inhibitor
has_related_synonym: cyclooxygenase inhibitors
has_related_synonym: fatty acid cyclooxygenase inhibitor
has_related_synonym: fatty acid cyclooxygenase inhibitors
has_related_synonym: prostaglandin G/H synthase inhibitor
has_related_synonym: prostaglandin G/H synthase inhibitors
has_related_synonym: prostaglandin endoperoxide synthetase inhibitor
has_related_synonym: prostaglandin endoperoxide synthetase inhibitors
has_related_synonym: prostaglandin synthase inhibitor
has_related_synonym: prostaglandin synthase inhibitors
has_related_synonym: prostaglandin synthetase inhibitor
has_related_synonym: prostaglandin synthetase inhibitors
id: CHEBI:35544
in subset: 3 STAR

cardiovascular drug
type: Class
subclass of: drug
textual definition: A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cardiovascular agent
has_related_synonym: cardiovascular drugs
id: CHEBI:35554
in subset: 3 STAR

alpha-adrenergic agonist
type: Class
subclass of: adrenergic agonist
subclass of: alpha-adrenergic drug
textual definition: An agent that selectively binds to and activates alpha-adrenergic receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: alpha-adrenergic agonists
has_related_synonym: alpha-adrenergic receptor agonist
has_related_synonym: alpha-adrenoceptor agonists
id: CHEBI:35569
in subset: 3 STAR

EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
type: Class
subclass of: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
textual definition: An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor which interferes with the activity of the enzyme protein tyrosine phosphatases (PTPs), EC 3.1.3.48, involved in the removal of phosphate groups from phosphorylated tyrosine residues on proteins.
imported from: chebi.owl
has cross-reference: Wikipedia:Protein-tyrosine-phosphatase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitors
has_related_synonym: EC 3.1.3.48 inhibitor
has_related_synonym: EC 3.1.3.48 inhibitors
has_related_synonym: PPT-phosphatase inhibitor
has_related_synonym: PPT-phosphatase inhibitors
has_related_synonym: PTP-phosphatase inhibitor
has_related_synonym: PTP-phosphatase inhibitors
has_related_synonym: PTPase inhibitor
has_related_synonym: PTPase inhibitors
has_related_synonym: [phosphotyrosine]protein phosphatase inhibitor
has_related_synonym: [phosphotyrosine]protein phosphatase inhibitors
has_related_synonym: phosphoprotein phosphatase (phosphotyrosine) inhibitor
has_related_synonym: phosphoprotein phosphatase (phosphotyrosine) inhibitors
has_related_synonym: phosphotyrosine histone phosphatase inhibitor
has_related_synonym: phosphotyrosine histone phosphatase inhibitors
has_related_synonym: phosphotyrosine phosphatase inhibitor
has_related_synonym: phosphotyrosine phosphatase inhibitors
has_related_synonym: phosphotyrosine protein phosphatase inhibitor
has_related_synonym: phosphotyrosine protein phosphatase inhibitors
has_related_synonym: phosphotyrosylprotein phosphatase inhibitor
has_related_synonym: phosphotyrosylprotein phosphatase inhibitors
has_related_synonym: protein phosphotyrosine phosphatase inhibitor
has_related_synonym: protein phosphotyrosine phosphatase inhibitors
has_related_synonym: protein tyrosine phosphatase inhibitor
has_related_synonym: protein tyrosine phosphatase inhibitors
has_related_synonym: protein-tyrosine-phosphatase (EC 3.1.3.48) inhibitor
has_related_synonym: protein-tyrosine-phosphatase (EC 3.1.3.48) inhibitors
has_related_synonym: protein-tyrosine-phosphatase inhibitor
has_related_synonym: protein-tyrosine-phosphatase inhibitors
has_related_synonym: protein-tyrosine-phosphate phosphohydrolase inhibitor
has_related_synonym: protein-tyrosine-phosphate phosphohydrolase inhibitors
has_related_synonym: tyrosine O-phosphate phosphatase inhibitor
has_related_synonym: tyrosine O-phosphate phosphatase inhibitors
has_related_synonym: tyrosylprotein phosphatase inhibitor
has_related_synonym: tyrosylprotein phosphatase inhibitors
id: CHEBI:35608
in subset: 3 STAR

antineoplastic agent
type: Class
subclass of: drug
textual definition: A substance that inhibits or prevents the proliferation of neoplasms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anticancer agent
has_related_synonym: anticancer agents
has_related_synonym: antineoplastic
has_related_synonym: antineoplastic agents
has_related_synonym: cytostatic
id: CHEBI:35610
in subset: 3 STAR

flavouring agent
type: Class
subclass of: food additive
textual definition: A food additive that is used to added improve the taste or odour of a food.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: flavoring agent
has_related_synonym: flavoring agents
has_related_synonym: flavour enhancer
has_related_synonym: flavour enhancers
has_related_synonym: flavouring agents
id: CHEBI:35617
in subset: 3 STAR

vasodilator agent
type: Class
subclass of: cardiovascular drug
textual definition: A drug used to cause dilation of the blood vessels.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: vasodilator
has_related_synonym: vasodilator agents
id: CHEBI:35620
in subset: 3 STAR

anticonvulsant
type: Class
subclass of: central nervous system depressant
textual definition: A drug used to prevent seizures or reduce their severity.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Antiepileptika
has_related_synonym: Antiepileptikum
has_related_synonym: Antikonvulsiva
has_related_synonym: Antikonvulsivum
has_related_synonym: anti-convulsant
has_related_synonym: anti-convulsants
has_related_synonym: anti-convulsive agent
has_related_synonym: anti-convulsive agents
has_related_synonym: anticonvulsants
has_related_synonym: anticonvulsive agent
has_related_synonym: anticonvulsive agents
has_related_synonym: antiepileptic
has_related_synonym: antiepileptics
has_related_synonym: antiepileptique
has_related_synonym: antiepileptiques
id: CHEBI:35623
in subset: 3 STAR

EC 3.5.2.6 (beta-lactamase) inhibitor
type: Class
subclass of: EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor that interferes with the action of beta-lactamase (EC 3.5.2.6).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.2.6 (beta-lactamase) inhibitors
has_related_synonym: EC 3.5.2.6 inhibitor
has_related_synonym: EC 3.5.2.6 inhibitors
has_related_synonym: ampicillinase inhibitor
has_related_synonym: ampicillinase inhibitors
has_related_synonym: beta-lactam hydrolase inhibitor
has_related_synonym: beta-lactam hydrolase inhibitors
has_related_synonym: beta-lactamase (EC 3.5.2.6) inhibitor
has_related_synonym: beta-lactamase (EC 3.5.2.6) inhibitors
has_related_synonym: beta-lactamase A, B, C inhibitor
has_related_synonym: beta-lactamase A, B, C inhibitors
has_related_synonym: beta-lactamase AME I inhibitor
has_related_synonym: beta-lactamase AME I inhibitors
has_related_synonym: beta-lactamase I-III inhibitor
has_related_synonym: beta-lactamase I-III inhibitors
has_related_synonym: beta-lactamase inhibitor
has_related_synonym: beta-lactamase inhibitors
has_related_synonym: cephalosporin-beta-lactamase inhibitor
has_related_synonym: cephalosporin-beta-lactamase inhibitors
has_related_synonym: cephalosporinase inhibitor
has_related_synonym: cephalosporinase inhibitors
has_related_synonym: exopenicillinase inhibitor
has_related_synonym: exopenicillinase inhibitors
has_related_synonym: neutrapen inhibitor
has_related_synonym: neutrapen inhibitors
has_related_synonym: penicillin amido-beta-lactamhydrolase inhibitor
has_related_synonym: penicillin amido-beta-lactamhydrolase inhibitors
has_related_synonym: penicillin beta-lactamase inhibitor
has_related_synonym: penicillin beta-lactamase inhibitors
has_related_synonym: penicillinase I, II inhibitor
has_related_synonym: penicillinase I, II inhibitors
has_related_synonym: penicillinase inhibitor
has_related_synonym: penicillinase inhibitors
id: CHEBI:35625
in subset: 3 STAR

EC 1.17.3.2 (xanthine oxidase) inhibitor
type: Class
subclass of: EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor
textual definition: An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.17.3.2 (xanthine oxidase) inhibitors
has_related_synonym: EC 1.17.3.2 inhibitor
has_related_synonym: EC 1.17.3.2 inhibitors
has_related_synonym: Schardinger enzyme inhibitor
has_related_synonym: Schardinger enzyme inhibitors
has_related_synonym: hypoxanthine oxidase inhibitor
has_related_synonym: hypoxanthine oxidase inhibitors
has_related_synonym: hypoxanthine-xanthine oxidase inhibitor
has_related_synonym: hypoxanthine-xanthine oxidase inhibitors
has_related_synonym: hypoxanthine:oxygen oxidoreductase inhibitor
has_related_synonym: hypoxanthine:oxygen oxidoreductase inhibitors
has_related_synonym: xanthine oxidase (EC 1.17.3.2) inhibitor
has_related_synonym: xanthine oxidase (EC 1.17.3.2) inhibitors
has_related_synonym: xanthine oxidase inhibitor
has_related_synonym: xanthine oxidase inhibitors
has_related_synonym: xanthine oxidoreductase inhibitor
has_related_synonym: xanthine oxidoreductase inhibitors
has_related_synonym: xanthine:O2 oxidoreductase inhibitor
has_related_synonym: xanthine:O2 oxidoreductase inhibitors
has_related_synonym: xanthine:oxygen oxidoreductase inhibitor
has_related_synonym: xanthine:oxygen oxidoreductase inhibitors
has_related_synonym: xanthine:xanthine oxidase inhibitor
has_related_synonym: xanthine:xanthine oxidase inhibitors
id: CHEBI:35634
in subset: 3 STAR

adrenergic uptake inhibitor
type: Class
subclass of: adrenergic agent
textual definition: Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ARI
has_related_synonym: NERI
has_related_synonym: NRI
has_related_synonym: adrenergic reuptake inhibitor
has_related_synonym: adrenergic reuptake inhibitors
has_related_synonym: adrenergic uptake inhibitors
has_related_synonym: norepinephrine reuptake inhibitor
has_related_synonym: norepinephrine reuptake inhibitors
id: CHEBI:35640
in subset: 3 STAR

HIV protease inhibitor
type: Class
subclass of: protease inhibitor
subclass of: anti-HIV agent
textual definition: An inhibitor of HIV protease, an enzyme required for production of proteins needed for viral assembly.
imported from: chebi.owl
has cross-reference: Wikipedia:Protease_inhibitor_(pharmacology)
has_obo_namespace: chebi_ontology
has_related_synonym: HIV protease inhibitors
id: CHEBI:35660
in subset: 3 STAR

EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
imported from: chebi.owl
has cross-reference: PMID:1464741
has cross-reference: PMID:15531285
has cross-reference: PMID:20467214
has cross-reference: Wikipedia:HMG-CoA_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: HMG-CoA reductase inhibitor
has_related_synonym: HMG-CoA reductase inhibitors
has_related_synonym: hydroxymethylglutaryl-CoA reductase inhibitor
has_related_synonym: hydroxymethylglutaryl-CoA reductase inhibitors
id: CHEBI:35664
in subset: 3 STAR

antihypertensive agent
type: Class
subclass of: cardiovascular drug
textual definition: Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
imported from: chebi.owl
has cross-reference: Wikipedia:Antihypertensive_drug
has_obo_namespace: chebi_ontology
has_related_synonym: antihypertensive
has_related_synonym: antihypertensive agents
has_related_synonym: antihypertensive drug
has_related_synonym: antihypertensive drugs
id: CHEBI:35674
in subset: 3 STAR

histamine agonist
type: Class
subclass of: histaminergic drug
textual definition: A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: histamine agonists
id: CHEBI:35678
in subset: 3 STAR

antilipemic drug
type: Class
subclass of: drug
textual definition: A substance used to treat hyperlipidemia (an excess of lipids in the blood).
imported from: chebi.owl
has cross-reference: Wikipedia:Hypolipidemic_agent
has_obo_namespace: chebi_ontology
has_related_synonym: antihyperlipemic
has_related_synonym: antihyperlipemics
has_related_synonym: antihyperlipidaemic agent
has_related_synonym: antihyperlipidaemic agents
has_related_synonym: antihyperlipidaemic drug
has_related_synonym: antihyperlipidaemic drugs
has_related_synonym: antihyperlipidemic
has_related_synonym: antihyperlipidemic agent
has_related_synonym: antihyperlipidemic agents
has_related_synonym: antihyperlipidemic drug
has_related_synonym: antihyperlipidemic drugs
has_related_synonym: antihyperlipidemics
has_related_synonym: antilipemic
has_related_synonym: antilipemic drugs
has_related_synonym: antilipemics
has_related_synonym: hypolipidemic agent
has_related_synonym: hypolipidemic agents
has_related_synonym: lipid-lowering agent
has_related_synonym: lipid-lowering agents
has_related_synonym: lipid-lowering drug
has_related_synonym: lipid-lowering drugs
id: CHEBI:35679
in subset: 3 STAR

antiplatyhelmintic drug
type: Class
subclass of: anthelminthic drug
textual definition: An agent used to treat cestode, trematode, or other flatworm infestations in man or animals.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antiplatyhelmintic agent
has_related_synonym: antiplatyhelmintic drugs
id: CHEBI:35684
in subset: 3 STAR

xenobiotic
type: Class
subclass of: biological role
textual definition: A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
imported from: chebi.owl
has_alternative_id: CHEBI:10074
has_alternative_id: CHEBI:27333
has cross-reference: KEGG:C06708
has cross-reference: Wikipedia:Xenobiotic
alternative_term: Xenobiotic
alternative_term: xenobiotic
alternative_term: xenobiotics
has_obo_namespace: chebi_ontology
has_related_synonym: xenobiotic compounds
id: CHEBI:35703
in subset: 3 STAR

immunosuppressive agent
type: Class
subclass of: immunomodulator
textual definition: An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: immunosuppressant
has_related_synonym: immunosuppressive agents
has_related_synonym: inmunosupresor
id: CHEBI:35705
in subset: 3 STAR

sedative
type: Class
subclass of: central nervous system depressant
textual definition: A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hypnotics
has_related_synonym: hypnotics and sedatives
has_related_synonym: sedative drug
has_related_synonym: sedatives
has_related_synonym: sedatives and hypnotics
id: CHEBI:35717
in subset: 3 STAR

antifungal agent
type: Class
subclass of: antimicrobial agent
textual definition: An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antifungal
has_related_synonym: antifungal agents
has_related_synonym: antifungal drug
has_related_synonym: antifungal drugs
has_related_synonym: antifungals
id: CHEBI:35718
in subset: 3 STAR

leprostatic drug
type: Class
subclass of: antimycobacterial drug
textual definition: A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: leprostatic
has_related_synonym: leprostatic agent
has_related_synonym: leprostatic drugs
id: CHEBI:35816
in subset: 3 STAR

coccidiostat
type: Class
subclass of: antiprotozoal drug
textual definition: An agent useful in the treatment or prevention of coccidiosis in man or animals.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anticoccidial agent
has_related_synonym: coccidiostats
id: CHEBI:35818
in subset: 3 STAR

antiprotozoal drug
type: Class
subclass of: antiparasitic agent
subclass of: antimicrobial drug
textual definition: Any antimicrobial drug which is used to treat or prevent protozoal infections.
imported from: chebi.owl
has cross-reference: Wikipedia:Antiprotozoal_agent
has_obo_namespace: chebi_ontology
has_related_synonym: antiprotozoal agent
has_related_synonym: antiprotozoal agents
has_related_synonym: antiprotozoal drugs
id: CHEBI:35820
in subset: 3 STAR

anticholesteremic drug
type: Class
subclass of: antilipemic drug
textual definition: A substance used to lower plasma cholesterol levels.
imported from: chebi.owl
has_alternative_id: CHEBI:64906
has_obo_namespace: chebi_ontology
has_related_synonym: anticholesteremic
has_related_synonym: anticholesteremic agent
has_related_synonym: anticholesteremic drugs
has_related_synonym: antihypercholesterolemic
has_related_synonym: antihypercholesterolemic agent
has_related_synonym: antihypercholesterolemic agents
has_related_synonym: antihypercholesterolemic drug
has_related_synonym: antihypercholesterolemic drugs
has_related_synonym: antihypercholesterolemics
has_related_synonym: cholesterol inhibitor
has_related_synonym: cholesterol-lowering agent
has_related_synonym: cholesterol-lowering agents
has_related_synonym: cholesterol-lowering drug
has_related_synonym: cholesterol-lowering drugs
has_related_synonym: hypocholesteremic agent
id: CHEBI:35821
in subset: 3 STAR

uricosuric drug
type: Class
subclass of: gout suppressant
subclass of: renal agent
textual definition: A gout suppressant that acts directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: uricosuric agent
has_related_synonym: uricosuric drugs
id: CHEBI:35841
in subset: 3 STAR

antirheumatic drug
type: Class
subclass of: drug
textual definition: A drug used to treat rheumatoid arthritis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-rheumatic drugs
has_related_synonym: antirheumatic agent
has_related_synonym: antirheumatic drugs
id: CHEBI:35842
in subset: 3 STAR

gout suppressant
type: Class
subclass of: antirheumatic drug
textual definition: A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: gout suppressants
id: CHEBI:35845
in subset: 3 STAR

renal agent
type: Class
subclass of: drug
textual definition: A drug used for its effect on the kidneys' regulation of body fluid composition and volume.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: renal agents
id: CHEBI:35846
in subset: 3 STAR

lipoxygenase inhibitor
type: Class
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
textual definition: A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: lipooxygenase inhibitor
has_related_synonym: lipoxygenase inhibitors
id: CHEBI:35856
in subset: 3 STAR

serotonergic agonist
type: Class
subclass of: serotonergic drug
textual definition: An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 5-HT agonist
has_related_synonym: 5-hydroxytryptamine agonist
has_related_synonym: serotonergic agonists
has_related_synonym: serotonin agonist
has_related_synonym: serotonin agonists
id: CHEBI:35941
in subset: 3 STAR

neurotransmitter agent
type: Class
subclass of: drug
subclass of: pharmacological role
textual definition: A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: neurotransmitter agents
id: CHEBI:35942
in subset: 3 STAR

antimicrobial drug
type: Class
subclass of: antimicrobial agent
subclass of: antiinfective agent
textual definition: A drug used to treat or prevent microbial infections.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antimicrobial drugs
id: CHEBI:36043
in subset: 3 STAR

antiviral drug
type: Class
subclass of: antiviral agent
subclass of: antimicrobial drug
textual definition: A substance used in the prophylaxis or therapy of virus diseases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-viral drug
has_related_synonym: anti-virus drug
has_related_synonym: antiviral drugs
id: CHEBI:36044
in subset: 3 STAR

antibacterial drug
type: Class
subclass of: antibacterial agent
subclass of: antimicrobial drug
textual definition: A drug used to treat or prevent bacterial infections.
imported from: chebi.owl
has cross-reference: Wikipedia:Antibacterial
has_obo_namespace: chebi_ontology
has_related_synonym: antibacterial drugs
id: CHEBI:36047
in subset: 3 STAR

antitreponemal drug
type: Class
subclass of: antibacterial drug
textual definition: A drug used in the treatment of infections with bacteria of the genus Treponema.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antitreponemal agent
has_related_synonym: antitreponemal drugs
id: CHEBI:36050
in subset: 3 STAR

antisyphilitic drug
type: Class
subclass of: antitreponemal drug
textual definition: A substance that is used in the treatment of syphilis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antisyphilitic agent
has_related_synonym: antisyphilitic agents
has_related_synonym: antisyphilitic drugs
has_related_synonym: antisyphilitics
id: CHEBI:36051
in subset: 3 STAR

acaricide drug
type: Class
subclass of: acaricide
subclass of: antiparasitic agent
textual definition: A drug used to treat infestations with arthropods of the subclass Acari (mites and ticks).
imported from: chebi.owl
has cross-reference: Wikipedia:Acaricide
has_obo_namespace: chebi_ontology
has_related_synonym: acaricide drugs
id: CHEBI:36053
in subset: 3 STAR

oxytocic
type: Class
subclass of: drug
textual definition: A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (abortifacients).
imported from: chebi.owl
alternative_term: oxytocic
has_obo_namespace: chebi_ontology
has_related_synonym: oxytocic agents
has_related_synonym: oxytocic drugs
has_related_synonym: uterine stimulants
id: CHEBI:36063
in subset: 3 STAR

taurocholate
type: Class
subclass of: molecular entity
textual definition: An organosulfonate oxoanion that is the conjugate base of taurocholic acid.
imported from: chebi.owl
charge: -1
formula: C26H44NO7S
inchi: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1
inchikey: WBWWGRHZICKQGZ-HZAMXZRMSA-M
mass: 514.69610
monoisotopicmass: 514.28440
has cross-reference: MetaCyc:CPD-3743
has cross-reference: Reaxys:3919947
alternative_term: 2-[(3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonate
alternative_term: taurocholate
has_obo_namespace: chebi_ontology
id: CHEBI:36257
in subset: 3 STAR

local anaesthetic
type: Class
subclass of: anaesthetic
textual definition: Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block.
imported from: chebi.owl
alternative_term: local anaesthetic
has_obo_namespace: chebi_ontology
has_related_synonym: Lokalanaesthetikum
has_related_synonym: anesthesique local
has_related_synonym: local anaesthetics
has_related_synonym: local anesthetics
id: CHEBI:36333
in subset: 3 STAR

trypanocidal drug
type: Class
subclass of: antiprotozoal drug
textual definition: A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antitrypanosomal agent
has_related_synonym: antitrypanosomal agents
has_related_synonym: antitrypanosomal drug
has_related_synonym: antitrypanosomal drugs
has_related_synonym: trypanocidal drugs
has_related_synonym: trypanocide
has_related_synonym: trypanosomicidal agents
id: CHEBI:36335
in subset: 3 STAR

anabolic agent
type: Class
subclass of: hormone
textual definition: A compound which stimulates anabolism and inhibits catabolism. Anabolic agents stimulate the development of muscle mass, strength, and power.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:36413
in subset: 3 STAR

interferon inducer
type: Class
subclass of: drug
textual definition: An agent that promotes the production and release of interferons.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: interferon inducers
id: CHEBI:36710
in subset: 3 STAR

EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
type: Class
subclass of: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
textual definition: Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16).
imported from: chebi.owl
has_alternative_id: CHEBI:62670
has cross-reference: Wikipedia:Phosphoprotein_phosphatase
has cross-reference: Wikipedia:Protein_serine/threonine_phosphatase
has_obo_namespace: chebi_ontology
has_related_synonym: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor
has_related_synonym: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors
has_related_synonym: Aspergillus awamori acid protein phosphatase inhibitor
has_related_synonym: Aspergillus awamori acid protein phosphatase inhibitors
has_related_synonym: BCKDH phosphatase inhibitor
has_related_synonym: BCKDH phosphatase inhibitors
has_related_synonym: EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors
has_related_synonym: EC 3.1.3.16 inhibitor
has_related_synonym: EC 3.1.3.16 inhibitors
has_related_synonym: HMG-CoA reductase phosphatase inhibitor
has_related_synonym: HMG-CoA reductase phosphatase inhibitors
has_related_synonym: branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor
has_related_synonym: branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors
has_related_synonym: calcineurin inhibitor
has_related_synonym: calcineurin inhibitors
has_related_synonym: casein phosphatase inhibitor
has_related_synonym: casein phosphatase inhibitors
has_related_synonym: phosphatase 2A inhibitor
has_related_synonym: phosphatase 2A inhibitors
has_related_synonym: phosphatase 2B inhibitor
has_related_synonym: phosphatase 2B inhibitors
has_related_synonym: phosphatase C-II inhibitor
has_related_synonym: phosphatase C-II inhibitors
has_related_synonym: phosphatase H-II inhibitor
has_related_synonym: phosphatase H-II inhibitors
has_related_synonym: phosphatase I inhibitor
has_related_synonym: phosphatase I inhibitors
has_related_synonym: phosphatase IB inhibitor
has_related_synonym: phosphatase IB inhibitors
has_related_synonym: phosphatase II inhibitor
has_related_synonym: phosphatase II inhibitors
has_related_synonym: phosphatase III inhibitor
has_related_synonym: phosphatase III inhibitors
has_related_synonym: phosphatase IV inhibitor
has_related_synonym: phosphatase IV inhibitors
has_related_synonym: phosphatase SP inhibitor
has_related_synonym: phosphatase SP inhibitors
has_related_synonym: phosphoprotein phosphatase (EC 3.1.3.16) inhibitor
has_related_synonym: phosphoprotein phosphatase (EC 3.1.3.16) inhibitors
has_related_synonym: phosphoprotein phosphatase inhibitor
has_related_synonym: phosphoprotein phosphatase inhibitors
has_related_synonym: phosphoprotein phosphohydrolase inhibitor
has_related_synonym: phosphoprotein phosphohydrolase inhibitors
has_related_synonym: phosphopyruvate dehydrogenase phosphatase inhibitor
has_related_synonym: phosphopyruvate dehydrogenase phosphatase inhibitors
has_related_synonym: phosphospectrin phosphatase inhibitor
has_related_synonym: phosphospectrin phosphatase inhibitors
has_related_synonym: polycation modulated (PCM-) phosphatase inhibitor
has_related_synonym: polycation modulated (PCM-) phosphatase inhibitors
has_related_synonym: protein D phosphatase inhibitor
has_related_synonym: protein D phosphatase inhibitors
has_related_synonym: protein phosphatase inhibitor
has_related_synonym: protein phosphatase inhibitors
has_related_synonym: protein phosphatase-1 inhibitor
has_related_synonym: protein phosphatase-1 inhibitors
has_related_synonym: protein phosphatase-2A inhibitor
has_related_synonym: protein phosphatase-2A inhibitors
has_related_synonym: protein phosphatase-2B inhibitor
has_related_synonym: protein phosphatase-2B inhibitors
has_related_synonym: protein phosphatase-2C inhibitor
has_related_synonym: protein phosphatase-2C inhibitors
has_related_synonym: protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors
has_related_synonym: protein serine/threonine phosphatase inhibitor
has_related_synonym: protein serine/threonine phosphatase inhibitors
has_related_synonym: serine/threonine specific protein phosphatase inhibitor
has_related_synonym: serine/threonine specific protein phosphatase inhibitors
id: CHEBI:37153
in subset: 3 STAR

diagnostic imaging agent
type: Class
subclass of: diagnostic agent
textual definition: A substance administered to enhance contrast in images of the inside of the body obtained using X-rays, gamma-rays, sound waves, radio waves (MRI), or radioactive particles in order to diagnose disease.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:37334
in subset: 3 STAR

MRI contrast agent
type: Class
subclass of: diagnostic imaging agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:37335
in subset: 1 STAR

radioactive imaging agent
type: Class
subclass of: diagnostic imaging agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:37336
in subset: 3 STAR

ultrasound contrast agent
type: Class
subclass of: diagnostic imaging agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:37337
in subset: 1 STAR

radioopaque medium
type: Class
subclass of: diagnostic imaging agent
textual definition: A substance having the property of absorbing, and therefore being opaque to, electromagnetic radiation, particularly X-rays.
imported from: chebi.owl
has cross-reference: Wikipedia:Contrast_medium
has_obo_namespace: chebi_ontology
has_related_synonym: contrast media
has_related_synonym: radiocontrast agent
has_related_synonym: radiocontrast agents
has_related_synonym: radioopaque media
has_related_synonym: radiopaque media
has_related_synonym: radiopaque medium
id: CHEBI:37338
in subset: 3 STAR

EC 2.7.7.6 (RNA polymerase) inhibitor
type: Class
subclass of: EC 2.7.7.* (nucleotidyltransferase) inhibitor
textual definition: An EC 2.7.7.* (nucleotidyltransferase) inhibitor that interferes with the action of RNA polymerase (EC 2.7.7.6).
imported from: chebi.owl
has cross-reference: Wikipedia:RNA_polymerase
has_obo_namespace: chebi_ontology
has_related_synonym: C RNA formation factors inhibitor
has_related_synonym: C RNA formation factors inhibitors
has_related_synonym: C ribonucleic acid formation factors inhibitor
has_related_synonym: C ribonucleic acid formation factors inhibitors
has_related_synonym: DNA-dependent RNA nucleotidyltransferase inhibitor
has_related_synonym: DNA-dependent RNA nucleotidyltransferase inhibitors
has_related_synonym: DNA-dependent RNA polymerase inhibitor
has_related_synonym: DNA-dependent RNA polymerase inhibitors
has_related_synonym: DNA-dependent ribonucleate nucleotidyltransferase inhibitor
has_related_synonym: DNA-dependent ribonucleate nucleotidyltransferase inhibitors
has_related_synonym: DNA-directed RNA polymerase inhibitor
has_related_synonym: DNA-directed RNA polymerase inhibitors
has_related_synonym: DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitor
has_related_synonym: DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitors
has_related_synonym: EC 2.7.7.6 (RNA polymerase) inhibitors
has_related_synonym: EC 2.7.7.6 inhibitor
has_related_synonym: EC 2.7.7.6 inhibitors
has_related_synonym: RNA nucleotidyltransferase (DNA-directed) inhibitor
has_related_synonym: RNA nucleotidyltransferase (DNA-directed) inhibitors
has_related_synonym: RNA nucleotidyltransferase inhibitor
has_related_synonym: RNA nucleotidyltransferase inhibitors
has_related_synonym: RNA polymerase (EC 2.7.7.6) inhibitor
has_related_synonym: RNA polymerase (EC 2.7.7.6) inhibitors
has_related_synonym: RNA polymerase I inhibitor
has_related_synonym: RNA polymerase I inhibitors
has_related_synonym: RNA polymerase II inhibitor
has_related_synonym: RNA polymerase II inhibitors
has_related_synonym: RNA polymerase III inhibitor
has_related_synonym: RNA polymerase III inhibitors
has_related_synonym: RNA polymerase inhibitor
has_related_synonym: RNA polymerase inhibitors
has_related_synonym: RNA transcriptase inhibitor
has_related_synonym: RNA transcriptase inhibitors
has_related_synonym: deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitor
has_related_synonym: deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitors
has_related_synonym: directed RNA polymerase inhibitor
has_related_synonym: nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitor
has_related_synonym: nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitors
has_related_synonym: ribonucleate nucleotidyltransferase inhibitor
has_related_synonym: ribonucleate nucleotidyltransferase inhibitors
has_related_synonym: ribonucleate polymerase inhibitor
has_related_synonym: ribonucleate polymerase inhibitors
has_related_synonym: ribonucleic acid nucleotidyltransferase inhibitor
has_related_synonym: ribonucleic acid nucleotidyltransferase inhibitors
has_related_synonym: ribonucleic acid polymerase inhibitor
has_related_synonym: ribonucleic acid polymerase inhibitors
has_related_synonym: ribonucleic acid transcriptase inhibitor
has_related_synonym: ribonucleic acid transcriptase inhibitors
has_related_synonym: ribonucleic polymerase inhibitor
has_related_synonym: ribonucleic polymerase inhibitors
has_related_synonym: ribonucleic transcriptase inhibitor
has_related_synonym: ribonucleic transcriptase inhibitors
has_related_synonym: transcriptase inhibitor
has_related_synonym: transcriptase inhibitors
id: CHEBI:37416
in subset: 3 STAR

acid
type: Class
subclass of: chemical role
textual definition: An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).
imported from: chebi.owl
has_alternative_id: CHEBI:13800
has_alternative_id: CHEBI:13801
has_alternative_id: CHEBI:22209
has_alternative_id: CHEBI:2426
has cross-reference: KEGG:C00174
alternative_term: Acid
alternative_term: acid
has_obo_namespace: chebi_ontology
has_related_synonym: Saeure
has_related_synonym: Saeuren
has_related_synonym: acide
has_related_synonym: acido
has_related_synonym: acids
id: CHEBI:37527
in subset: 3 STAR

protease inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases).
imported from: chebi.owl
has cross-reference: Wikipedia:Protease_inhibitor_(biology)
has_obo_namespace: chebi_ontology
has_related_synonym: protease inhibitors
id: CHEBI:37670
in subset: 3 STAR

protein kinase inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: protein kinase inhibitors
id: CHEBI:37699
in subset: 3 STAR

EC 2.7.11.13 (protein kinase C) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitor
has_related_synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitors
has_related_synonym: EC 2.7.11.13 (protein kinase C) inhibitors
has_related_synonym: EC 2.7.11.13 inhibitor
has_related_synonym: EC 2.7.11.13 inhibitors
has_related_synonym: PKC inhibitor
has_related_synonym: PKC inhibitors
has_related_synonym: PKCalpha inhibitor
has_related_synonym: PKCalpha inhibitors
has_related_synonym: PKCbeta inhibitor
has_related_synonym: PKCbeta inhibitors
has_related_synonym: PKCdelta inhibitor
has_related_synonym: PKCdelta inhibitors
has_related_synonym: PKCepsilon inhibitor
has_related_synonym: PKCepsilon inhibitors
has_related_synonym: PKCgamma inhibitor
has_related_synonym: PKCgamma inhibitors
has_related_synonym: PKCzeta inhibitor
has_related_synonym: PKCzeta inhibitors
has_related_synonym: PKN3 inhibitor
has_related_synonym: PKN3 inhibitors
has_related_synonym: Pkc1p inhibitor
has_related_synonym: Pkc1p inhibitors
has_related_synonym: STK24 inhibitor
has_related_synonym: STK24 inhibitors
has_related_synonym: cPKC inhibitor
has_related_synonym: cPKC inhibitors
has_related_synonym: cPKCalpha inhibitor
has_related_synonym: cPKCalpha inhibitors
has_related_synonym: cPKCbeta inhibitor
has_related_synonym: cPKCbeta inhibitors
has_related_synonym: cPKCgamma inhibitor
has_related_synonym: cPKCgamma inhibitors
has_related_synonym: calcium-dependent protein kinase C inhibitor
has_related_synonym: calcium-dependent protein kinase C inhibitors
has_related_synonym: calcium-independent protein kinase C inhibitor
has_related_synonym: calcium-independent protein kinase C inhibitors
has_related_synonym: calcium/phospholipid dependent protein kinase inhibitor
has_related_synonym: calcium/phospholipid dependent protein kinase inhibitors
has_related_synonym: nPKC inhibitor
has_related_synonym: nPKC inhibitors
has_related_synonym: nPKCdelta inhibitor
has_related_synonym: nPKCdelta inhibitors
has_related_synonym: nPKCepsilon inhibitor
has_related_synonym: nPKCepsilon inhibitors
has_related_synonym: nPKCeta inhibitor
has_related_synonym: nPKCeta inhibitors
has_related_synonym: nPKCtheta inhibitor
has_related_synonym: nPKCtheta inhibitors
has_related_synonym: protein kinase C (EC 2.7.11.13) inhibitor
has_related_synonym: protein kinase C (EC 2.7.11.13) inhibitors
has_related_synonym: protein kinase C inhibitor
has_related_synonym: protein kinase C inhibitors
has_related_synonym: protein kinase Cepsilon inhibitor
has_related_synonym: protein kinase Cepsilon inhibitors
id: CHEBI:37700
in subset: 3 STAR

EC 3.1.1.8 (cholinesterase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
textual definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: BChE inhibitor
has_related_synonym: BChE inhibitors
has_related_synonym: BtChoEase inhibitor
has_related_synonym: BtChoEase inhibitors
has_related_synonym: EC 3.1.1.8 (cholinesterase) inhibitors
has_related_synonym: EC 3.1.1.8 inhibitor
has_related_synonym: EC 3.1.1.8 inhibitors
has_related_synonym: anticholineesterase inhibitor
has_related_synonym: anticholineesterase inhibitors
has_related_synonym: anticholinesterase
has_related_synonym: anticholinesterases
has_related_synonym: benzoylcholinesterase inhibitor
has_related_synonym: benzoylcholinesterase inhibitors
has_related_synonym: butyrylcholine esterase inhibitor
has_related_synonym: butyrylcholine esterase inhibitors
has_related_synonym: butyrylcholinesterase inhibitor
has_related_synonym: butyrylcholinesterase inhibitors
has_related_synonym: choline esterase II (unspecific) inhibitor
has_related_synonym: choline esterase II (unspecific) inhibitors
has_related_synonym: choline esterase inhibitor
has_related_synonym: choline esterase inhibitors
has_related_synonym: cholinesterase (EC 3.1.1.8) inhibitor
has_related_synonym: cholinesterase (EC 3.1.1.8) inhibitors
has_related_synonym: cholinesterase inhibitor
has_related_synonym: non-specific cholinesterase inhibitor
has_related_synonym: non-specific cholinesterase inhibitors
has_related_synonym: propionylcholinesterase inhibitor
has_related_synonym: propionylcholinesterase inhibitors
has_related_synonym: pseudocholinesterase inhibitor
has_related_synonym: pseudocholinesterase inhibitors
id: CHEBI:37733
in subset: 3 STAR

growth hormone
type: Class
subclass of: hormone
textual definition: A hormone that specifically regulates growth.
imported from: chebi.owl
has cross-reference: CAS:9002-72-6
has cross-reference: KEGG:C18181
has_obo_namespace: chebi_ontology
has_related_synonym: GH
has_related_synonym: Somatotropin
has_related_synonym: Wachstumshormon
has_related_synonym: growth hormones
id: CHEBI:37845
in subset: 3 STAR

plant hormone
type: Class
subclass of: hormone
subclass of: plant growth regulator
textual definition: A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds.
imported from: chebi.owl
has_alternative_id: CHEBI:26158
has cross-reference: Wikipedia:Phytohormone
has_obo_namespace: chebi_ontology
has_related_synonym: phytohormone
has_related_synonym: phytohormones
has_related_synonym: plant growth factor
has_related_synonym: plant growth factors
has_related_synonym: plant growth hormone
has_related_synonym: plant growth hormones
has_related_synonym: plant hormones
id: CHEBI:37848
in subset: 3 STAR

adrenergic agonist
type: Class
subclass of: adrenergic agent
textual definition: An agent that selectively binds to and activates adrenergic receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adrenergic agonists
has_related_synonym: adrenergic receptor agonist
has_related_synonym: adrenoceptor agonists
has_related_synonym: adrenomimetic
has_related_synonym: adrenomimetics
id: CHEBI:37886
in subset: 3 STAR

adrenergic antagonist
type: Class
subclass of: adrenergic agent
textual definition: An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adrenergic antagonists
has_related_synonym: adrenergic blockaders
has_related_synonym: adrenergic blocker
has_related_synonym: adrenergic blockers
has_related_synonym: adrenergic receptor blockaders
has_related_synonym: adrenoceptor antagonists
id: CHEBI:37887
in subset: 3 STAR

alpha-adrenergic antagonist
type: Class
subclass of: adrenergic antagonist
subclass of: alpha-adrenergic drug
textual definition: An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: alpha-adrenergic antagonists
has_related_synonym: alpha-adrenergic blocker
has_related_synonym: alpha-adrenergic blockers
has_related_synonym: alpha-adrenergic receptor blockaders
has_related_synonym: alpha-adrenoceptor antagonists
id: CHEBI:37890
in subset: 3 STAR

phenothiazine antipsychotic drug
type: Class
subclass of: first generation antipsychotic
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phenothiazine antipsychotic drugs
has_related_synonym: phenothiazine antipsychotics
has_related_synonym: phenothiazine neuroleptics
id: CHEBI:37930
in subset: 3 STAR

H1-receptor antagonist
type: Class
subclass of: histamine antagonist
textual definition: H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
imported from: chebi.owl
has cross-reference: PMID:22035879
has_obo_namespace: chebi_ontology
has_related_synonym: H1 antihistaminics
has_related_synonym: H1 receptor antagonists
has_related_synonym: H1 receptor blockaders
has_related_synonym: H1-receptor antagonists
has_related_synonym: H1-receptor blocker
has_related_synonym: H1-receptor blockers
has_related_synonym: classical antihistamines
has_related_synonym: classical antihistaminics
id: CHEBI:37955
in subset: 3 STAR

histamine antagonist
type: Class
subclass of: histaminergic drug
subclass of: antagonist
textual definition: Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
imported from: chebi.owl
has cross-reference: PMID:22035879
has cross-reference: Wikipedia:Antihistamines
has_obo_namespace: chebi_ontology
has_related_synonym: antihistamine
has_related_synonym: antihistamines
has_related_synonym: antihistaminico
has_related_synonym: antihistaminics
has_related_synonym: histamine receptor blocker
has_related_synonym: histamine receptor blockers
id: CHEBI:37956
in subset: 3 STAR

histaminergic drug
type: Class
subclass of: neurotransmitter agent
textual definition: Drugs used for their actions on histaminergic systems.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: histamine agents
has_related_synonym: histamine drugs
has_related_synonym: histaminergic agent
has_related_synonym: histaminergic agents
has_related_synonym: histaminergic drugs
id: CHEBI:37957
in subset: 3 STAR

dye
type: Class
subclass of: application
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Farbstoff
has_related_synonym: Farbstoffe
has_related_synonym: colorante
has_related_synonym: colorantes
has_related_synonym: dyes
has_related_synonym: teinture
has_related_synonym: teintures
id: CHEBI:37958
in subset: 3 STAR

H2-receptor antagonist
type: Class
subclass of: histamine antagonist
textual definition: H2-receptor antagonists are the drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of endogenous histamine.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: H2 receptor antagonists
has_related_synonym: H2 receptor blockaders
has_related_synonym: H2-receptor blocker
has_related_synonym: H2-receptor blockers
has_related_synonym: histamine H2 receptor antagonist
has_related_synonym: histamine H2 receptor antagonists
id: CHEBI:37961
in subset: 3 STAR

adrenergic agent
type: Class
subclass of: neurotransmitter agent
textual definition: Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adrenergic agents
has_related_synonym: adrenergic drug
has_related_synonym: adrenergic drugs
has_related_synonym: adrenergic neuron agents
has_related_synonym: adrenergics
id: CHEBI:37962
in subset: 3 STAR

triazine insecticide
type: Class
subclass of: insecticide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:38060
in subset: 1 STAR

antimalarial
type: Class
subclass of: antiplasmodial drug
textual definition: A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antimalarials
id: CHEBI:38068
in subset: 3 STAR

anti-arrhythmia drug
type: Class
subclass of: cardiovascular drug
textual definition: A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-arrhythmia agent
has_related_synonym: antiarrhythmic agent
id: CHEBI:38070
in subset: 3 STAR

cardiotonic drug
type: Class
subclass of: cardiovascular drug
textual definition: A drug that has a strengthening effect on the heart or that can increase cardiac output.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cardiotonic drugs
id: CHEBI:38147
in subset: 3 STAR

phytosiderophore
type: Class
subclass of: iron(3+) chelator
subclass of: iron ionophore
textual definition: Any of low-molecular-mass iron(III)-chelating compounds produced by plants for the purpose of the transport and sequestration of iron.
imported from: chebi.owl
has_alternative_id: CHEBI:26122
has_alternative_id: CHEBI:38117
has_obo_namespace: chebi_ontology
has_related_synonym: Phytosiderophor
has_related_synonym: phytosiderophores
id: CHEBI:38155
in subset: 3 STAR

iron chelator
type: Class
subclass of: chelator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: iron chelating agent
has_related_synonym: iron chelating agents
has_related_synonym: iron chelators
id: CHEBI:38157
in subset: 3 STAR

chelator
type: Class
subclass of: ligand
textual definition: A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
imported from: chebi.owl
has_alternative_id: CHEBI:23090
has_alternative_id: CHEBI:3585
has_alternative_id: CHEBI:6789
has cross-reference: KEGG:C00917
has cross-reference: KEGG:C02169
has_obo_namespace: chebi_ontology
has_related_synonym: Chelating agent
has_related_synonym: Metal chelator
has_related_synonym: chelating agents
has_related_synonym: chelators
has_related_synonym: complexon
id: CHEBI:38161
in subset: 3 STAR

iron(2+) chelator
type: Class
subclass of: iron chelator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:38162
in subset: 1 STAR

calcium channel blocker
type: Class
subclass of: calcium channel modulator
subclass of: antagonist
textual definition: One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: calcium channel antagonist
has_related_synonym: calcium channel antagonists
has_related_synonym: calcium channel blockers
id: CHEBI:38215
in subset: 3 STAR

phytotoxin
type: Class
subclass of: toxin
subclass of: plant metabolite
textual definition: Any toxin produced by a plant.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phytotoxins
id: CHEBI:38231
in subset: 3 STAR

DNA polymerase inhibitor
type: Class
subclass of: EC 2.7.7.* (nucleotidyltransferase) inhibitor
textual definition: Any inhibitor of a DNA polymerase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:38234
in subset: 3 STAR

EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor
type: Class
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
textual definition: An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor that interferes with the activity of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27).
imported from: chebi.owl
has_alternative_id: CHEBI:50380
has_obo_namespace: chebi_ontology
has_related_synonym: 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) inhibitor
has_related_synonym: 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) inhibitors
has_related_synonym: 4-hydroxyphenylpyruvate dioxygenase inhibitor
has_related_synonym: 4-hydroxyphenylpyruvate dioxygenase inhibitors
has_related_synonym: 4-hydroxyphenylpyruvate hydroxylase inhibitor
has_related_synonym: 4-hydroxyphenylpyruvate hydroxylase inhibitors
has_related_synonym: 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitor
has_related_synonym: 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitors
has_related_synonym: 4-hydroxyphenylpyruvic acid dioxygenase inhibitor
has_related_synonym: 4-hydroxyphenylpyruvic acid dioxygenase inhibitors
has_related_synonym: EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitors
has_related_synonym: EC 1.13.11.27 inhibitor
has_related_synonym: EC 1.13.11.27 inhibitors
has_related_synonym: HPPD inhibitor
has_related_synonym: HPPD inhibitors
has_related_synonym: p-hydroxyphenylpyruvate dioxygenase inhibitor
has_related_synonym: p-hydroxyphenylpyruvate dioxygenase inhibitors
has_related_synonym: p-hydroxyphenylpyruvate hydroxylase inhibitor
has_related_synonym: p-hydroxyphenylpyruvate hydroxylase inhibitors
has_related_synonym: p-hydroxyphenylpyruvate oxidase inhibitor
has_related_synonym: p-hydroxyphenylpyruvate oxidase inhibitors
has_related_synonym: p-hydroxyphenylpyruvic acid hydroxylase inhibitor
has_related_synonym: p-hydroxyphenylpyruvic acid hydroxylase inhibitors
has_related_synonym: p-hydroxyphenylpyruvic hydroxylase inhibitor
has_related_synonym: p-hydroxyphenylpyruvic hydroxylase inhibitors
has_related_synonym: p-hydroxyphenylpyruvic oxidase inhibitor
has_related_synonym: p-hydroxyphenylpyruvic oxidase inhibitors
id: CHEBI:38317
in subset: 3 STAR

cholinergic drug
type: Class
subclass of: neurotransmitter agent
textual definition: Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cholinergic agent
has_related_synonym: cholinergic drugs
has_related_synonym: cholinomimetic
id: CHEBI:38323
in subset: 3 STAR

cholinergic agonist
type: Class
subclass of: cholinergic drug
textual definition: Any drug that binds to and activates cholinergic receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: acetylcholine agonist
has_related_synonym: acetylcholine agonists
has_related_synonym: acetylcholine receptor agonist
has_related_synonym: cholinergic agonists
has_related_synonym: cholinomimetic
has_related_synonym: cholinomimetics
id: CHEBI:38324
in subset: 3 STAR

muscarinic agonist
type: Class
subclass of: cholinergic agonist
textual definition: Any drug that binds to and activates a muscarinic cholinergic receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: muscarinic acetylcholine receptor agonist
has_related_synonym: muscarinic agonists
has_related_synonym: muscarinic cholinergic agonist
has_related_synonym: muscarinic cholinergic agonists
id: CHEBI:38325
in subset: 3 STAR

ecdysone agonist
type: Class
subclass of: insect growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ecdysone agonists
has_related_synonym: ecdysone mimetic
id: CHEBI:38456
in subset: 3 STAR

carbamate insecticide
type: Class
subclass of: insecticide
subclass of: EC 3.1.1.7 (acetylcholinesterase) inhibitor
textual definition: Derivatives of carbamic acid with insecticidal properties of general formula ROC(=O)NR(1)R(2), where ROH is an alcohol, oxime, or phenol and R(1) is hydrogen or methyl. Like organophosphate insecticides, they are cholinesterase inhibitors, but carbamate insecticides differ in action from the organophosphates in that the inhibitory effect on cholinesterase is generally brief.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carbamate insecticides
id: CHEBI:38461
in subset: 3 STAR

EC 3.1.1.7 (acetylcholinesterase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
textual definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
imported from: chebi.owl
has cross-reference: Wikipedia:Acetylcholinesterase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: AChEI
has_related_synonym: AcCholE inhibitor
has_related_synonym: AcCholE inhibitors
has_related_synonym: EC 3.1.1.7 (acetylcholinesterase) inhibitors
has_related_synonym: EC 3.1.1.7 inhibitor
has_related_synonym: EC 3.1.1.7 inhibitors
has_related_synonym: acetyl.beta-methylcholinesterase inhibitor
has_related_synonym: acetyl.beta-methylcholinesterase inhibitors
has_related_synonym: acetylcholine acetylhydrolase inhibitor
has_related_synonym: acetylcholine acetylhydrolase inhibitors
has_related_synonym: acetylcholine esterase inhibitor
has_related_synonym: acetylcholine hydrolase inhibitor
has_related_synonym: acetylcholine hydrolase inhibitors
has_related_synonym: acetylcholinesterase (EC 3.1.1.7) inhibitor
has_related_synonym: acetylcholinesterase (EC 3.1.1.7) inhibitors
has_related_synonym: acetylcholinesterase inhibitor
has_related_synonym: acetylcholinesterase inhibitors
has_related_synonym: acetylthiocholinesterase inhibitor
has_related_synonym: acetylthiocholinesterase inhibitors
has_related_synonym: choline esterase I inhibitor
has_related_synonym: choline esterase I inhibitors
has_related_synonym: cholinesterase inhibitor
has_related_synonym: cholinesterase inhibitors
has_related_synonym: true cholinesterase inhibitor
has_related_synonym: true cholinesterase inhibitors
id: CHEBI:38462
in subset: 3 STAR

electron-transport chain inhibitor
type: Class
subclass of: pathway inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:38496
in subset: 1 STAR

respiratory-chain inhibitor
type: Class
subclass of: electron-transport chain inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:38497
in subset: 1 STAR

mitochondrial NADH:ubiquinone reductase inhibitor
type: Class
subclass of: mitochondrial respiratory-chain inhibitor
subclass of: EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mitochondrial NADH dehydrogenase inhibitor
has_related_synonym: mitochondrial complex I inhibitor
has_related_synonym: mitochondrial complex I inhibitors
id: CHEBI:38498
in subset: 3 STAR

mitochondrial cytochrome-bc1 complex inhibitor
type: Class
subclass of: mitochondrial respiratory-chain inhibitor
subclass of: cytochrome-bc1 complex inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mitochondrial complex III inhibitor
has_related_synonym: mitochondrial complex III inhibitors
id: CHEBI:38499
in subset: 3 STAR

EC 1.9.3.1 (cytochrome c oxidase) inhibitor
type: Class
subclass of: mitochondrial respiratory-chain inhibitor
subclass of: EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor
textual definition: An EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor that interferes with the action of cytochrome c oxidase (EC 1.9.3.1).
imported from: chebi.owl
has_alternative_id: CHEBI:38501
has_alternative_id: CHEBI:62966
has cross-reference: PMID:12969439
has cross-reference: Wikipedia:Cytochrome_c_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: CcO inhibitor
has_related_synonym: EC 1.9.3.1 (cytochrome c oxidase) inhibitors
has_related_synonym: EC 1.9.3.1 inhibitor
has_related_synonym: EC 1.9.3.1 inhibitors
has_related_synonym: NADH cytochrome c oxidase inhibitor
has_related_synonym: NADH cytochrome c oxidase inhibitors
has_related_synonym: Warburg's respiratory enzyme inhibitor
has_related_synonym: Warburg's respiratory enzyme inhibitors
has_related_synonym: complex IV (mitochondrial electron transport) inhibitor
has_related_synonym: complex IV (mitochondrial electron transport) inhibitors
has_related_synonym: cytochrome a3 inhibitor
has_related_synonym: cytochrome a3 inhibitors
has_related_synonym: cytochrome aa3 inhibitor
has_related_synonym: cytochrome aa3 inhibitors
has_related_synonym: cytochrome c oxidase (EC 1.9.3.1) inhibitor
has_related_synonym: cytochrome c oxidase (EC 1.9.3.1) inhibitors
has_related_synonym: cytochrome c oxidase inhibitor
has_related_synonym: cytochrome c oxidase inhibitors
has_related_synonym: cytochrome oxidase inhibitor
has_related_synonym: cytochrome oxidase inhibitors
has_related_synonym: cytochrome-c oxidase inhibitor
has_related_synonym: cytochrome-c oxidase inhibitors
has_related_synonym: ferrocytochrome c oxidase inhibitor
has_related_synonym: ferrocytochrome c oxidase inhibitors
has_related_synonym: ferrocytochrome-c:oxygen oxidoreductase inhibitor
has_related_synonym: ferrocytochrome-c:oxygen oxidoreductase inhibitors
has_related_synonym: indophenol oxidase inhibitor
has_related_synonym: indophenol oxidase inhibitors
has_related_synonym: indophenolase inhibitor
has_related_synonym: indophenolase inhibitors
has_related_synonym: mitochondrial complex IV inhibitor
has_related_synonym: mitochondrial complex IV inhibitors
has_related_synonym: mitochondrial cytochrome-c oxidase inhibitors
id: CHEBI:38500
in subset: 3 STAR

cytochrome-bc1 complex inhibitor
type: Class
subclass of: respiratory-chain inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:38502
in subset: 1 STAR

EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor
type: Class
subclass of: respiratory-chain inhibitor
subclass of: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor
textual definition: A respiratory-chain inhibitor that interferes with the action of the the enzyme NADH:ubiquinone reductase (H(+)-translocating), EC 1.6.5.3.
imported from: chebi.owl
has cross-reference: Wikipedia:NADH_dehydrogenase_(ubiquinone)
has_obo_namespace: chebi_ontology
has_related_synonym: DPNH-coenzyme Q reductase inhibitor
has_related_synonym: DPNH-ubiquinone reductase inhibitor
has_related_synonym: EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitor
has_related_synonym: EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitors
has_related_synonym: EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitors
has_related_synonym: EC 1.6.5.3 inhibitor
has_related_synonym: EC 1.6.5.3 inhibitors
has_related_synonym: NADH coenzyme Q1 reductase inhibitor
has_related_synonym: NADH coenzyme Q1 reductase inhibitors
has_related_synonym: NADH dehydrogenase (ubiquinone) inhibitor
has_related_synonym: NADH dehydrogenase (ubiquinone) inhibitors
has_related_synonym: NADH-CoQ oxidoreductase inhibitor
has_related_synonym: NADH-CoQ oxidoreductase inhibitors
has_related_synonym: NADH-CoQ reductase inhibitor
has_related_synonym: NADH-CoQ reductase inhibitors
has_related_synonym: NADH-Q6 oxidoreductase inhibitor
has_related_synonym: NADH-coenzyme Q oxidoreductase inhibitors
has_related_synonym: NADH-coenzyme Q reductase inhibitor
has_related_synonym: NADH-coenzyme Q reductase inhibitors
has_related_synonym: NADH-ubiquinone oxidoreductase inhibitor
has_related_synonym: NADH-ubiquinone oxidoreductase inhibitors
has_related_synonym: NADH-ubiquinone reductase inhibitor
has_related_synonym: NADH-ubiquinone reductase inhibitors
has_related_synonym: NADH-ubiquinone-1 reductase inhibitor
has_related_synonym: NADH-ubiquinone-1 reductase inhibitors
has_related_synonym: NADH2 dehydrogenase (ubiquinone) inhibitor
has_related_synonym: NADH:ubiquinone oxidoreductase complex inhibitor
has_related_synonym: NADH:ubiquinone oxidoreductase inhibitor
has_related_synonym: NADH:ubiquinone oxidoreductase inhibitors
has_related_synonym: NADH:ubiquinone reductase (H(+)-translocating) inhibitor
has_related_synonym: NADH:ubiquinone reductase (H(+)-translocating) inhibitors
has_related_synonym: NADH:ubiquinone reductase (H+-translocating) inhibitor
has_related_synonym: NADH:ubiquinone reductase inhibitor
has_related_synonym: coenzyme Q reductase
has_related_synonym: complex 1 dehydrogenase inhibitor
has_related_synonym: complex I (NADH:Q1 oxidoreductase) inhibitors
has_related_synonym: complex I (electron transport chain) inhibitors
has_related_synonym: complex I (mitochondrial electron transport) inhibitors
has_related_synonym: dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor
has_related_synonym: electron transfer complex I inhibitor
has_related_synonym: electron transfer complex I inhibitors
has_related_synonym: mitochondrial electron transport complex 1 inhibitor
has_related_synonym: mitochondrial electron transport complex I inhibitor
has_related_synonym: mitochondrial electron transport complex I inhibitors
has_related_synonym: reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor
has_related_synonym: reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitors
has_related_synonym: type 1 dehydrogenase inhibitor
has_related_synonym: type 1 dehydrogenase inhibitors
has_related_synonym: ubiquinone reductase inhibitor
has_related_synonym: ubiquinone reductase inhibitors
id: CHEBI:38503
in subset: 3 STAR

rosuvastatin
type: Class
subclass of: molecular entity
textual definition: A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer).
imported from: chebi.owl
charge: 0
formula: C22H28FN3O6S
inchi: InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1
inchikey: BPRHUIZQVSMCRT-VEUZHWNKSA-N
mass: 481.53800
monoisotopicmass: 481.16828
has cross-reference: CAS:287714-41-4
has cross-reference: DrugBank:DB01098
has cross-reference: Drug_Central:2406
has cross-reference: HMDB:HMDB0015230
has cross-reference: KEGG:D08492
has cross-reference: PMID:17970755
has cross-reference: PMID:18509206
has cross-reference: PMID:19724024
has cross-reference: PMID:19956889
has cross-reference: PMID:23806820
has cross-reference: PMID:23881596
has cross-reference: PMID:23944632
has cross-reference: PMID:24072337
has cross-reference: PMID:24076283
has cross-reference: PMID:24076297
has cross-reference: PMID:24156555
has cross-reference: PMID:24163149
has cross-reference: PMID:24230979
has cross-reference: PMID:24253250
has cross-reference: PMID:24259612
has cross-reference: PMID:24304551
has cross-reference: PMID:24333476
has cross-reference: PMID:24353409
has cross-reference: PMID:24410968
has cross-reference: PMID:24417785
has cross-reference: PMID:24434545
has cross-reference: PMID:24440231
has cross-reference: PMID:24440960
has cross-reference: PMID:24444439
has cross-reference: PMID:24452083
has cross-reference: PMID:24456217
has cross-reference: PMID:24467235
has cross-reference: Patent:US2013035316
has cross-reference: Reaxys:9670765
has cross-reference: Wikipedia:Rosuvastatin
alternative_term: (3R,5S,6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid
has_related_synonym: (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
has_related_synonym: rosuvastatin
id: CHEBI:38545
in subset: 3 STAR

EC 1.4.3.4 (monoamine oxidase) inhibitor
type: Class
subclass of: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor
textual definition: An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Monoamine_oxidase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.3.4 (monoamine oxidase) inhibitors
has_related_synonym: EC 1.4.3.4 inhibitor
has_related_synonym: EC 1.4.3.4 inhibitors
has_related_synonym: MAO A inhibitor
has_related_synonym: MAO A inhibitors
has_related_synonym: MAO B inhibitor
has_related_synonym: MAO B inhibitors
has_related_synonym: MAO inhibitor
has_related_synonym: MAO inhibitors
has_related_synonym: MAO-A inhibitor
has_related_synonym: MAO-A inhibitors
has_related_synonym: MAO-B inhibitor
has_related_synonym: MAO-B inhibitors
has_related_synonym: adrenalin oxidase inhibitor
has_related_synonym: adrenalin oxidase inhibitors
has_related_synonym: adrenaline oxidase inhibitor
has_related_synonym: adrenaline oxidase inhibitors
has_related_synonym: amine oxidase (flavin-containing) inhibitor
has_related_synonym: amine oxidase (flavin-containing) inhibitors
has_related_synonym: amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitor
has_related_synonym: amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitors
has_related_synonym: amine:oxygen oxidoreductase (deaminating) inhibitor
has_related_synonym: amine:oxygen oxidoreductase (deaminating) inhibitors
has_related_synonym: epinephrine oxidase inhibitor
has_related_synonym: epinephrine oxidase inhibitors
has_related_synonym: monoamine oxidase (EC 1.4.3.4) inhibitor
has_related_synonym: monoamine oxidase (EC 1.4.3.4) inhibitors
has_related_synonym: monoamine oxidase A inhibitor
has_related_synonym: monoamine oxidase A inhibitors
has_related_synonym: monoamine oxidase B inhibitor
has_related_synonym: monoamine oxidase B inhibitors
has_related_synonym: monoamine oxidase inhibitor
has_related_synonym: monoamine oxidase inhibitors
has_related_synonym: monoamine:O2 oxidoreductase (deaminating) inhibitor
has_related_synonym: monoamine:O2 oxidoreductase (deaminating) inhibitors
has_related_synonym: serotonin deaminase inhibitor
has_related_synonym: serotonin deaminase inhibitors
has_related_synonym: tyraminase inhibitor
has_related_synonym: tyraminase inhibitors
has_related_synonym: tyramine oxidase inhibitor
has_related_synonym: tyramine oxidase inhibitors
id: CHEBI:38623
in subset: 3 STAR

membrane transport modulator
type: Class
subclass of: biophysical role
textual definition: Any agent that affects the transport of molecular entities across a biological membrane.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: membrane transport modulators
id: CHEBI:38632
in subset: 3 STAR

sodium channel blocker
type: Class
subclass of: sodium channel modulator
textual definition: An agent that inhibits sodium influx through cell membranes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Na channel blocker
has_related_synonym: sodium channel blockers
id: CHEBI:38633
in subset: 3 STAR

voltage-gated sodium channel blocker
type: Class
subclass of: sodium channel blocker
textual definition: Any sodium channel blocker that interferes with the activity of voltage-gated sodium channels.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Nav channel blocker
has_related_synonym: Nav channel blockers
has_related_synonym: voltage-dependent sodium channel blockers
id: CHEBI:38634
in subset: 3 STAR

tyrosine kinase inhibitor
type: Class
subclass of: protein kinase inhibitor
textual definition: Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
imported from: chebi.owl
has cross-reference: Wikipedia:Tyrosine-kinase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: TKI inhibitor
has_related_synonym: TKI inhibitors
has_related_synonym: protein tyrosine kinase inhibitor
has_related_synonym: protein tyrosine kinase inhibitors
has_related_synonym: tyrosine kinase inhibitors
has_related_synonym: tyrphostin
has_related_synonym: tyrphostins
id: CHEBI:38637
in subset: 3 STAR

pediculicide
type: Class
subclass of: insecticide
textual definition: Substance used to treat lice (genus Pediculus) infestation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pediculicides
id: CHEBI:38706
in subset: 3 STAR

calcium channel agonist
type: Class
subclass of: calcium channel modulator
textual definition: Agents that increase calcium influx into calcium channels of excitable tissues.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: calcium channel activator
has_related_synonym: calcium channel activators
has_related_synonym: calcium channel agonists
id: CHEBI:38807
in subset: 3 STAR

calcium channel modulator
type: Class
subclass of: membrane transport modulator
textual definition: A membrane transport modulator that is able to regulate intracellular calcium levels.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: calcium channel modulators
id: CHEBI:38808
in subset: 3 STAR

ryanodine receptor modulator
type: Class
subclass of: calcium channel modulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: RyR modulator
has_related_synonym: ryanodine receptor modulators
has_related_synonym: ryanodine-sensitive calcium channel modulator
has_related_synonym: ryanodine-sensitive calcium-release channel modulator
id: CHEBI:38809
in subset: 3 STAR

nonionic surfactant
type: Class
subclass of: surfactant
textual definition: A surfactant with an uncharged hydrophilic headgroup.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: non-ionic surfactant
has_related_synonym: nonionic surfactants
id: CHEBI:38828
in subset: 3 STAR

blood substitute
type: Class
subclass of: pharmaceutical
textual definition: A substance that can carry oxygen to and carbon dioxide away from the tissues when introduced into the blood stream. Blood substitutes are used to replace hemoglobin in severe hemorrhage and also to perfuse isolated organs.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: artificial blood
has_related_synonym: blood substitutes
has_related_synonym: oxygen carrier
id: CHEBI:38849
in subset: 3 STAR

anaesthetic
type: Class
subclass of: drug
textual definition: Substance which produces loss of feeling or sensation.
imported from: chebi.owl
alternative_term: anaesthetic
has_obo_namespace: chebi_ontology
has_related_synonym: Anaesthetika
has_related_synonym: Anaesthetikum
has_related_synonym: anaesthetics
has_related_synonym: anesthetic agent
has_related_synonym: anesthetic drug
has_related_synonym: anesthetics
id: CHEBI:38867
in subset: 3 STAR

general anaesthetic
type: Class
subclass of: anaesthetic
textual definition: Substance that produces loss of consciousness.
imported from: chebi.owl
alternative_term: general anaesthetic
has_obo_namespace: chebi_ontology
has_related_synonym: Allgemeinanaesthetika
has_related_synonym: Allgemeinanaesthetikum
has_related_synonym: general anaesthetics
has_related_synonym: general anesthetics
id: CHEBI:38869
in subset: 3 STAR

inhalation anaesthetic
type: Class
subclass of: general anaesthetic
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Inhalationsanaesthetika
has_related_synonym: Inhalationsanaesthetikum
has_related_synonym: Inhalationsnarkotika
has_related_synonym: Inhalationsnarkotikum
has_related_synonym: anesthetic gases
has_related_synonym: inhalation anesthetics
id: CHEBI:38870
in subset: 3 STAR

intravenous anaesthetic
type: Class
subclass of: general anaesthetic
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: i.v.-Anaesthetika
has_related_synonym: i.v.-Anaesthetikum
has_related_synonym: intravenous anesthetics
id: CHEBI:38877
in subset: 3 STAR

schistosomicide drug
type: Class
subclass of: antiplatyhelmintic drug
textual definition: Drugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antischistosoma
has_related_synonym: antischistosomal drug
has_related_synonym: schistosomicide
has_related_synonym: schistosomicide drugs
has_related_synonym: schistosomicides
id: CHEBI:38941
in subset: 3 STAR

ectoparasiticide
type: Class
subclass of: antiparasitic agent
imported from: chebi.owl
has cross-reference: Wikipedia:Ectoparasiticide
has_obo_namespace: chebi_ontology
has_related_synonym: ectoparasiticides
id: CHEBI:38956
in subset: 3 STAR

GABA-gated chloride channel antagonist
type: Class
subclass of: membrane transport modulator
subclass of: antagonist
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GABA-gated chloride channel antagonists
id: CHEBI:38999
in subset: 3 STAR

sodium channel modulator
type: Class
subclass of: membrane transport modulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sodium channel modulators
id: CHEBI:39000
in subset: 3 STAR

Good's buffer substance
type: Class
subclass of: buffer
textual definition: Any member of a collection of zwitterionic buffer substances selected or devised for suitability in experimental biological systems according to a number of predetermined criteria. Named after Dr. Norman Good.
imported from: chebi.owl
has cross-reference: Wikipedia:Good's_buffers
has_obo_namespace: chebi_ontology
has_related_synonym: Good buffer substance
has_related_synonym: Good's buffer
has_related_synonym: Good's buffers
id: CHEBI:39011
in subset: 3 STAR

pyrethroid ester insecticide
type: Class
subclass of: pyrethroid insecticide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pyrethroid ester insecticides
id: CHEBI:39116
in subset: 3 STAR

Bronsted acid
type: Class
subclass of: donor
subclass of: acid
textual definition: A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
imported from: chebi.owl
alternative_term: Bronsted acid
has_obo_namespace: chebi_ontology
has_related_synonym: Bronsted-Saeure
has_related_synonym: acide de Bronsted
has_related_synonym: donneur d'hydron
has_related_synonym: hydron donor
id: CHEBI:39141
in subset: 3 STAR

Bronsted base
type: Class
subclass of: acceptor
subclass of: base
textual definition: A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
imported from: chebi.owl
alternative_term: Bronsted base
has_obo_namespace: chebi_ontology
has_related_synonym: Bronsted-Base
has_related_synonym: accepteur d'hydron
has_related_synonym: base de Bronsted
has_related_synonym: hydron acceptor
id: CHEBI:39142
in subset: 3 STAR

Lewis acid
type: Class
subclass of: acceptor
subclass of: acid
textual definition: A molecular entity that is an electron-pair acceptor and therefore able to form a covalent bond with an electron-pair donor (Lewis base), thereby producing a Lewis adduct.
imported from: chebi.owl
alternative_term: Lewis acid
has_obo_namespace: chebi_ontology
has_related_synonym: Lewis-Saeure
has_related_synonym: accepteur d'une paire d'electrons
has_related_synonym: acide de Lewis
has_related_synonym: electron acceptor
has_related_synonym: electron-pair acceptor
id: CHEBI:39143
in subset: 3 STAR

Lewis base
type: Class
subclass of: donor
subclass of: base
textual definition: A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct.
imported from: chebi.owl
alternative_term: Lewis base
has_obo_namespace: chebi_ontology
has_related_synonym: Lewis-Base
has_related_synonym: base de Lewis
has_related_synonym: donneur d'une paire d'electrons
has_related_synonym: electron donor
id: CHEBI:39144
in subset: 3 STAR

antibiotic insecticide
type: Class
subclass of: insecticide
subclass of: antibiotic pesticide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39208
in subset: 1 STAR

antibiotic pesticide
type: Class
subclass of: pesticide
subclass of: antimicrobial agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39215
in subset: 1 STAR

antibiotic acaricide
type: Class
subclass of: acaricide
subclass of: antibiotic pesticide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39216
in subset: 1 STAR

antibiotic nematicide
type: Class
subclass of: nematicide
subclass of: antibiotic pesticide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39217
in subset: 1 STAR

pyrethroid ester acaricide
type: Class
subclass of: acaricide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39259
in subset: 1 STAR

fumigant
type: Class
subclass of: pesticide
textual definition: A volatile or volatilizable chemical compound utilized for control of pests in buildings, soil, grain, as well as during processing of goods to be imported or exported to prevent transfer of exotic organisms.
imported from: chebi.owl
has cross-reference: Wikipedia:Fumigation
has_obo_namespace: chebi_ontology
has_related_synonym: fumigant pesticide
has_related_synonym: fumigants
id: CHEBI:39276
in subset: 3 STAR

fumigant insecticide
type: Class
subclass of: insecticide
subclass of: fumigant
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fumigant insecticides
id: CHEBI:39277
in subset: 3 STAR

sulfite ester acaricide
type: Class
subclass of: acaricide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39301
in subset: 1 STAR

mite growth regulator
type: Class
subclass of: acaricide
subclass of: growth regulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39316
in subset: 1 STAR

growth regulator
type: Class
subclass of: biological role
textual definition: Any chemical substance that inhibits the life-cycle of an organism.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: growth regulators
id: CHEBI:39317
in subset: 3 STAR

tetrazine acaricide
type: Class
subclass of: acaricide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39318
in subset: 1 STAR

pyrethroid ether insecticide
type: Class
subclass of: pyrethroid insecticide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pyrethroid ether insecticides
id: CHEBI:39351
in subset: 3 STAR

pyrethroid ether acaricide
type: Class
subclass of: acaricide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pyrethroid ether acaricides
id: CHEBI:39369
in subset: 3 STAR

homopteran inhibitor of chitin biosynthesis
type: Class
subclass of: chitin synthesis inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39378
in subset: 1 STAR

lepidopteran inhibitor of chitin biosynthesis
type: Class
subclass of: chitin synthesis inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39379
in subset: 1 STAR

bridged diphenyl acaricide
type: Class
subclass of: acaricide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bridged diphenyl acaricides
id: CHEBI:39412
in subset: 3 STAR

dinitrophenol insecticide
type: Class
subclass of: insecticide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: dinitrophenol insecticides
id: CHEBI:39415
in subset: 3 STAR

fluorescent probe
type: Class
subclass of: probe
textual definition: A role played by a fluorescent molecular entity used to study the microscopic environment by fluorescence spectroscopy.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:39442
in subset: 3 STAR

antiglaucoma drug
type: Class
subclass of: ophthalmology drug
textual definition: Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-glaucoma agent
has_related_synonym: anti-glaucoma agents
has_related_synonym: anti-glaucoma drug
has_related_synonym: anti-glaucoma drugs
has_related_synonym: antiglaucoma agent
has_related_synonym: antiglaucoma drugs
id: CHEBI:39456
in subset: 3 STAR

dextromethorphan
type: Class
subclass of: molecular entity
textual definition: A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
imported from: chebi.owl
charge: 0
formula: C18H25NO
inchi: InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
inchikey: MKXZASYAUGDDCJ-NJAFHUGGSA-N
mass: 271.404
monoisotopicmass: 271.19361
has_alternative_id: CHEBI:92579
has cross-reference: CAS:125-71-3
has cross-reference: DrugBank:DB00514
has cross-reference: Drug_Central:842
has cross-reference: HMDB:HMDB0001920
has cross-reference: KEGG:C06947
has cross-reference: KEGG:D03742
has cross-reference: LINCS:LSM-2726
has cross-reference: PMID:10869398
has cross-reference: PMID:12711372
has cross-reference: PMID:15505150
has cross-reference: PMID:17157116
has cross-reference: PMID:17461892
has cross-reference: PMID:17573115
has cross-reference: PMID:18160193
has cross-reference: PMID:18198471
has cross-reference: PMID:24269965
has cross-reference: PMID:2660263
has cross-reference: PMID:31094746
has cross-reference: PMID:7976530
has cross-reference: PMID:8158182
has cross-reference: PMID:9705419
has cross-reference: Reaxys:88549
has cross-reference: Wikipedia:Dextromethorphan
alternative_term: (4aS,10S,10aS)-6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene
alternative_term: 3-methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan
has_obo_namespace: chebi_ontology
has_related_synonym: (+)-3-methoxy-N-methylmorphinan
has_related_synonym: (+)-dextromethorphan
has_related_synonym: (9alpha,13alpha,14alpha)-3-methoxy-17-methylmorphinan
has_related_synonym: 3-methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan
has_related_synonym: Albutussin
has_related_synonym: Antussan
has_related_synonym: BA 2666
has_related_synonym: BA-2666
has_related_synonym: Balminil DM
has_related_synonym: Benylin DM
has_related_synonym: Calmylin
has_related_synonym: D-methorphan
has_related_synonym: DXM
has_related_synonym: Delsym
has_related_synonym: Dextromorphan
has_related_synonym: Medicon
has_related_synonym: Romilar
has_related_synonym: Tusilan
has_related_synonym: d-Methorphan
has_related_synonym: destrometerfano
has_related_synonym: dextromethorfan
has_related_synonym: dextromethorphan
has_related_synonym: dextromethorphane
has_related_synonym: dextromethorphanum
has_related_synonym: dextrometorfano
id: CHEBI:4470
in subset: 3 STAR

propofol
type: Class
subclass of: molecular entity
textual definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
imported from: chebi.owl
charge: 0
formula: C12H18O
inchi: InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
inchikey: OLBCVFGFOZPWHH-UHFFFAOYSA-N
mass: 178.27072
monoisotopicmass: 178.13577
smiles: CC(C)c1cccc(C(C)C)c1O
has_alternative_id: CHEBI:44914
has_alternative_id: CHEBI:8495
has cross-reference: Beilstein:1866484
has cross-reference: CAS:2078-54-8
has cross-reference: DrugBank:DB00818
has cross-reference: Drug_Central:2302
has cross-reference: KEGG:C07523
has cross-reference: KEGG:D00549
has cross-reference: LINCS:LSM-3847
has cross-reference: PDBeChem:PFL
has cross-reference: VSDB:1846
has cross-reference: Wikipedia:Propofol
alternative_term: 2,6-bis(propan-2-yl)phenol
alternative_term: Propofol
has_obo_namespace: chebi_ontology
has_related_synonym: 2,6-BIS(1-METHYLETHYL)PHENOL
has_related_synonym: 2,6-Diisopropylphenol
has_related_synonym: 2,6-bis(1-methylethyl)phenol
has_related_synonym: Diprivan
has_related_synonym: Disoprivan
has_related_synonym: Disoprofol
has_related_synonym: Rapinovet
has_related_synonym: propofol
has_related_synonym: propofolum
id: CHEBI:44915
in subset: 3 STAR

troleandomycin
type: Class
subclass of: molecular entity
textual definition: A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.
imported from: chebi.owl
charge: 0
formula: C41H67NO15
inchi: InChI=1S/C41H67NO15/c1-19-17-41(18-49-41)38(46)23(5)34(53-27(9)43)21(3)25(7)52-39(47)24(6)35(56-32-16-31(48-14)36(26(8)51-32)54-28(10)44)22(4)33(19)57-40-37(55-29(11)45)30(42(12)13)15-20(2)50-40/h19-26,30-37,40H,15-18H2,1-14H3/t19-,20+,21-,22+,23+,24+,25+,26-,30-,31-,32-,33-,34-,35-,36-,37+,40-,41+/m0/s1
inchikey: LQCLVBQBTUVCEQ-QTFUVMRISA-N
mass: 813.96840
monoisotopicmass: 813.45107
has_alternative_id: CHEBI:32267
has cross-reference: CAS:2751-09-9
has cross-reference: DrugBank:DB01361
has cross-reference: Drug_Central:2769
has cross-reference: HMDB:HMDB0015448
has cross-reference: KEGG:C12753
has cross-reference: KEGG:D01322
has cross-reference: LINCS:LSM-5510
has cross-reference: LIPID_MAPS_instance:LMPK04000042
has cross-reference: PDBeChem:TAO
has cross-reference: PMID:24335510
has cross-reference: PMID:24479850
has cross-reference: PMID:24889073
has cross-reference: PMID:24985121
has cross-reference: PMID:25392348
has cross-reference: PMID:25870103
has cross-reference: Reaxys:77547
has cross-reference: Wikipedia:Troleandomycin
alternative_term: (3R,5R,6S,7R,8R,11R,12S,13R,14S,15S)-12-[(4-O-acetyl-2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-{[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadecan-6-yl acetate
has_obo_namespace: chebi_ontology
has_related_synonym: Oleandocetine
has_related_synonym: Oleandomycin triacetate
has_related_synonym: Oleandomycin triacetyl ester
has_related_synonym: Triacetyloleandomycin
has_related_synonym: Triacetyloleandomycinum
has_related_synonym: Tribiocillina
has_related_synonym: Triocetin
has_related_synonym: troleandomicina
has_related_synonym: troleandomycin
has_related_synonym: troleandomycine
has_related_synonym: troleandomycinum
id: CHEBI:45735
in subset: 3 STAR

trifluoperazine
type: Class
subclass of: molecular entity
textual definition: A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C21H24F3N3S
inchi: InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
inchikey: ZEWQUBUPAILYHI-UHFFFAOYSA-N
mass: 407.49669
monoisotopicmass: 407.16430
has_alternative_id: CHEBI:45949
has_alternative_id: CHEBI:9709
has cross-reference: Beilstein:57272
has cross-reference: CAS:117-89-5
has cross-reference: DrugBank:DB00831
has cross-reference: Drug_Central:2740
has cross-reference: Gmelin:2415561
has cross-reference: HMDB:HMDB0014969
has cross-reference: KEGG:C07168
has cross-reference: KEGG:D08636
has cross-reference: LINCS:LSM-4010
has cross-reference: PDBeChem:TFP
has cross-reference: PMID:11121417
has cross-reference: PMID:14974020
has cross-reference: PMID:15722405
has cross-reference: PMID:1650428
has cross-reference: PMID:19277699
has cross-reference: PMID:19747949
has cross-reference: PMID:20544963
has cross-reference: PMID:7404501
has cross-reference: PMID:9730919
has cross-reference: Reaxys:57272
has cross-reference: Wikipedia:Trifluoperazine
alternative_term: 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
alternative_term: Trifluoperazine
has_obo_namespace: chebi_ontology
has_related_synonym: 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE
has_related_synonym: 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
has_related_synonym: trifluoperazina
has_related_synonym: trifluoperazine
has_related_synonym: trifluoperazinum
has_related_synonym: trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine
has_related_synonym: trifluoroperazine
has_related_synonym: trifluperazine
id: CHEBI:45951
in subset: 3 STAR

solvent
type: Class
subclass of: application
subclass of: chemical role
textual definition: A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
imported from: chebi.owl
has cross-reference: Wikipedia:Solvent
has_obo_namespace: chebi_ontology
has_related_synonym: Loesungsmittel
has_related_synonym: solvant
has_related_synonym: solvents
id: CHEBI:46787
in subset: 3 STAR

diclofenac
type: Class
subclass of: molecular entity
textual definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
imported from: chebi.owl
charge: 0
formula: C14H11Cl2NO2
inchi: InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
inchikey: DCOPUUMXTXDBNB-UHFFFAOYSA-N
mass: 296.150
monoisotopicmass: 295.01668
smiles: C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl
has_alternative_id: CHEBI:4507
has_alternative_id: CHEBI:47380
has cross-reference: CAS:15307-86-5
has cross-reference: DrugBank:DB00586
has cross-reference: Drug_Central:865
has cross-reference: HMDB:HMDB0014724
has cross-reference: KEGG:C01690
has cross-reference: KEGG:D07816
has cross-reference: LINCS:LSM-2160
has cross-reference: PDBeChem:DIF
has cross-reference: PMID:11322639
has cross-reference: PMID:1502708
has cross-reference: PMID:23777257
has cross-reference: PMID:27967303
has cross-reference: PMID:7838674
has cross-reference: Patent:NL6604752
has cross-reference: Patent:US3558690
has cross-reference: Reaxys:2146636
has cross-reference: VSDB:1933
has cross-reference: Wikipedia:Diclofenac
alternative_term: 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid
alternative_term: Diclofenac
alternative_term: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 2-((2,6-dichlorophenyl)amino)benzeneacetic acid
has_related_synonym: [2-(2,6-dichloroanilino)phenyl]acetic acid
has_related_synonym: diclofenac
has_related_synonym: diclofenac acid
has_related_synonym: diclofenaco
has_related_synonym: diclofenacum
has_related_synonym: diclofenamic acid
id: CHEBI:47381
in subset: 3 STAR

indicator
type: Class
subclass of: application
textual definition: Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Indikator
id: CHEBI:47867
in subset: 3 STAR

photosensitizing agent
type: Class
subclass of: drug
textual definition: A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: photosensitising agent
id: CHEBI:47868
in subset: 3 STAR

nicotinic acetylcholine receptor agonist
type: Class
subclass of: cholinergic agonist
textual definition: An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
imported from: chebi.owl
has_alternative_id: CHEBI:82738
has cross-reference: Wikipedia:Nicotinic_acetylcholine_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: muscarinic agonists
has_related_synonym: nicotinic acetylcholine receptor agonists
has_related_synonym: nicotinic agonist
has_related_synonym: nicotinic agonists
id: CHEBI:47958
in subset: 3 STAR

protein synthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: protein synthesis antagonist
has_related_synonym: protein synthesis antagonists
has_related_synonym: protein synthesis inhibitors
id: CHEBI:48001
in subset: 3 STAR

antiseptic drug
type: Class
subclass of: antiinfective agent
textual definition: A substance used locally on humans and other animals to destroy harmful microorganisms or to inhibit their activity (cf. disinfectants, which destroy microorganisms found on non-living objects, and antibiotics, which can be transported through the lymphatic system to destroy bacteria within the body).
imported from: chebi.owl
has cross-reference: Wikipedia:Antiseptic
has_obo_namespace: chebi_ontology
has_related_synonym: antiseptic
has_related_synonym: antiseptic agent
has_related_synonym: antiseptic agents
has_related_synonym: antiseptics
has_related_synonym: local antiinfective agents
has_related_synonym: local microbicides
has_related_synonym: topical antiinfective agents
has_related_synonym: topical microbicides
id: CHEBI:48218
in subset: 3 STAR

disinfectant
type: Class
subclass of: antimicrobial agent
textual definition: An antimicrobial agent that is applied to non-living objects to destroy harmful microorganisms or to inhibit their activity.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Desinfektionsmittel
has_related_synonym: desinfectant
has_related_synonym: disinfectants
has_related_synonym: disinfecting agent
id: CHEBI:48219
in subset: 3 STAR

serotonergic drug
type: Class
subclass of: neurotransmitter agent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: serotonergic agents
has_related_synonym: serotonergic drugs
has_related_synonym: serotonin drugs
id: CHEBI:48278
in subset: 3 STAR

serotonergic antagonist
type: Class
subclass of: serotonergic drug
textual definition: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 5-HT antagonists
has_related_synonym: 5-hydroxytryptamine antagonists
has_related_synonym: antiserotonergic agents
has_related_synonym: serotonin antagonists
has_related_synonym: serotonin blockaders
id: CHEBI:48279
in subset: 3 STAR

fragrance
type: Class
subclass of: application
textual definition: A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Parfuem
has_related_synonym: aroma
has_related_synonym: arome
has_related_synonym: essence
has_related_synonym: parfum
has_related_synonym: perfume
has_related_synonym: scent
id: CHEBI:48318
in subset: 3 STAR

serine proteinase inhibitor
type: Class
subclass of: protease inhibitor
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An exogenous or endogenous compound which inhibits serine endopeptidases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: serine proteinase inhibitors
id: CHEBI:48353
in subset: 3 STAR

polar solvent
type: Class
subclass of: solvent
textual definition: A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.
imported from: chebi.owl
alternative_term: polar solvent
has_obo_namespace: chebi_ontology
has_related_synonym: polar solvents
id: CHEBI:48354
in subset: 3 STAR

non-polar solvent
type: Class
subclass of: solvent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:48355
in subset: 1 STAR

protic solvent
type: Class
subclass of: Bronsted acid
subclass of: polar solvent
textual definition: A polar solvent that is capable of acting as a hydron (proton) donor.
imported from: chebi.owl
alternative_term: protogenic solvent
has_obo_namespace: chebi_ontology
id: CHEBI:48356
in subset: 3 STAR

aprotic solvent
type: Class
subclass of: solvent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:48357
in subset: 1 STAR

polar aprotic solvent
type: Class
subclass of: polar solvent
subclass of: aprotic solvent
textual definition: A solvent with a comparatively high relative permittivity (or dielectric constant), greater than ca. 15, and a sizable permanent dipole moment, that cannot donate suitably labile hydrogen atoms to form strong hydrogen bonds.
imported from: chebi.owl
alternative_term: dipolar aprotic solvent
has_obo_namespace: chebi_ontology
id: CHEBI:48358
in subset: 3 STAR

protophilic solvent
type: Class
subclass of: Bronsted base
subclass of: polar solvent
textual definition: Solvent that is capable of acting as a hydron (proton) acceptor.
imported from: chebi.owl
alternative_term: protophilic solvent
has_obo_namespace: chebi_ontology
has_related_synonym: HBA solvent
has_related_synonym: hydrogen bond acceptor solvent
id: CHEBI:48359
in subset: 3 STAR

amphiprotic solvent
type: Class
subclass of: protic solvent
subclass of: protophilic solvent
textual definition: Self-ionizing solvent possessing both characteristics of Bronsted acids and bases.
imported from: chebi.owl
alternative_term: amphiprotic solvent
has_obo_namespace: chebi_ontology
id: CHEBI:48360
in subset: 3 STAR

EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferase) inhibitor that interferes with the action of catechol O-methyltransferase (EC 2.1.1.6).
imported from: chebi.owl
has cross-reference: Wikipedia:Catechol_O-methyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: COMT inhibitor
has_related_synonym: COMT inhibitors
has_related_synonym: EC 2.1.1.6 (catechol O-methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.6 inhibitor
has_related_synonym: EC 2.1.1.6 inhibitors
has_related_synonym: S-adenosyl-L-methionine:catechol O-methyltransferase inhibitor
has_related_synonym: S-adenosyl-L-methionine:catechol O-methyltransferase inhibitors
has_related_synonym: catechol O-methyltransferase (EC 2.1.1.6) inhibitor
has_related_synonym: catechol O-methyltransferase (EC 2.1.1.6) inhibitors
has_related_synonym: catechol O-methyltransferase inhibitor
has_related_synonym: catechol O-methyltransferase inhibitors
has_related_synonym: catechol methyltransferase inhibitor
has_related_synonym: catechol methyltransferase inhibitors
has_related_synonym: catecholamine O-methyltransferase inhibitor
has_related_synonym: catecholamine O-methyltransferase inhibitors
id: CHEBI:48406
in subset: 3 STAR

antiparkinson drug
type: Class
subclass of: antidyskinesia agent
textual definition: A drug used in the treatment of Parkinson's disease.
imported from: chebi.owl
has cross-reference: Wikipedia:Antiparkinson
has_obo_namespace: chebi_ontology
has_related_synonym: antiparkinson agent
id: CHEBI:48407
in subset: 3 STAR

angiogenesis inhibitor
type: Class
subclass of: drug
textual definition: An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
imported from: chebi.owl
has_alternative_id: CHEBI:67170
has cross-reference: Wikipedia:Angiogenesis_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: angiogenesis antagonist
has_related_synonym: angiostatic agents
has_related_synonym: anti-angiogenic agent
id: CHEBI:48422
in subset: 3 STAR

topical anaesthetic
type: Class
subclass of: local anaesthetic
textual definition: A local anesthetic that is used to numb the surface of a body part.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: topical anaesthetics
has_related_synonym: topical anesthetic
id: CHEBI:48425
in subset: 3 STAR

calcimimetic
type: Class
subclass of: drug
textual definition: A drug that it mimics the action of calcium on tissues.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: calcimimetics
id: CHEBI:48525
in subset: 3 STAR

alpha-adrenergic drug
type: Class
subclass of: adrenergic agent
textual definition: Any drug that acts on an alpha-adrenergic receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: alpha-adrenergic drugs
id: CHEBI:48539
in subset: 3 STAR

beta-adrenergic drug
type: Class
subclass of: adrenergic agent
textual definition: Any of the drugs that act on beta-adrenergic receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: beta-adrenergic drugs
id: CHEBI:48540
in subset: 3 STAR

EC 1.1.1.21 (aldehyde reductase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ALR2 inhibitor
has_related_synonym: ALR2 inhibitors
has_related_synonym: EC 1.1.1.21 (aldehyde reductase) inhibitors
has_related_synonym: EC 1.1.1.21 inhibitor
has_related_synonym: EC 1.1.1.21 inhibitors
has_related_synonym: NADPH-aldopentose reductase inhibitor
has_related_synonym: NADPH-aldopentose reductase inhibitors
has_related_synonym: NADPH-aldose reductase inhibitor
has_related_synonym: NADPH-aldose reductase inhibitors
has_related_synonym: aldehyde reductase (EC 1.1.1.21) inhibitor
has_related_synonym: aldehyde reductase (EC 1.1.1.21) inhibitors
has_related_synonym: aldehyde reductase inhibitor
has_related_synonym: aldehyde reductase inhibitors
has_related_synonym: alditol:NAD(P)(+) 1-oxidoreductase inhibitor
has_related_synonym: alditol:NAD(P)(+) 1-oxidoreductase inhibitors
has_related_synonym: alditol:NADP oxidoreductase inhibitor
has_related_synonym: alditol:NADP oxidoreductase inhibitors
has_related_synonym: alditol:NADP(+) 1-oxidoreductase inhibitor
has_related_synonym: alditol:NADP(+) 1-oxidoreductase inhibitors
has_related_synonym: aldose reductase inhibitor
has_related_synonym: aldose reductase inhibitors
has_related_synonym: polyol dehydrogenase (NADP(+)) inhibitor
has_related_synonym: polyol dehydrogenase (NADP(+)) inhibitors
id: CHEBI:48550
in subset: 3 STAR

dopaminergic agent
type: Class
subclass of: neurotransmitter agent
textual definition: A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: dopamine agent
has_related_synonym: dopamine agents
has_related_synonym: dopamine drug
has_related_synonym: dopamine drugs
has_related_synonym: dopaminergic agents
id: CHEBI:48560
in subset: 3 STAR

dopaminergic antagonist
type: Class
subclass of: dopaminergic agent
subclass of: antagonist
textual definition: A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: dopamine antagonist
has_related_synonym: dopamine blocker
has_related_synonym: dopamine receptor antagonist
has_related_synonym: dopaminergic antagonists
id: CHEBI:48561
in subset: 3 STAR

radical scavenger
type: Class
subclass of: antioxidant
textual definition: A role played by a substance that can react readily with, and thereby eliminate, radicals.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: free radical scavengers
has_related_synonym: free-radical scavenger
id: CHEBI:48578
in subset: 3 STAR

gamma-secretase modulator
type: Class
subclass of: effector
textual definition: A modulator of gamma-secretase, one of the three endopeptidases that are specific for amyloid protein precursor and which have been identified based upon the region of the amyloid protein precursor which they cleave.
imported from: chebi.owl
has cross-reference: Wikipedia:Gamma_secretase
alternative_term: Gamma-secretase modulator
alternative_term: gamma-secretase modulator
has_obo_namespace: chebi_ontology
has_related_synonym: Gamma-secretase modulators
has_related_synonym: gamma secretase modulator
has_related_synonym: gamma secretase modulators
has_related_synonym: gamma-secretase modulators
id: CHEBI:48668
in subset: 3 STAR

antifibrinolytic drug
type: Class
subclass of: fibrin modulating drug
textual definition: A drug that prevent fibrinolysis or lysis of a blood clot or thrombus.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antifibrinolytic agent
has_related_synonym: antifibrinolytic agents
has_related_synonym: antifibrinolytic drugs
id: CHEBI:48675
in subset: 3 STAR

fibrin modulating drug
type: Class
subclass of: drug
textual definition: A drug that affects the function of fibrin in blood coagulation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fibrin modulating agent
has_related_synonym: fibrin modulating agents
has_related_synonym: fibrin modulating drugs
id: CHEBI:48676
in subset: 3 STAR

agonist
type: Class
subclass of: pharmacological role
textual definition: Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
imported from: chebi.owl
alternative_term: agonist
has_obo_namespace: chebi_ontology
has_related_synonym: agonista
has_related_synonym: agoniste
has_related_synonym: agonists
id: CHEBI:48705
in subset: 3 STAR

antagonist
type: Class
subclass of: pharmacological role
textual definition: Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.
imported from: chebi.owl
alternative_term: antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: antagonista
has_related_synonym: antagoniste
has_related_synonym: antagonists
id: CHEBI:48706
in subset: 3 STAR

estropipate
type: Class
subclass of: molecular entity
imported from: chebi.owl
charge: 0
formula: C18H22O5S.C4H10N2
formula: C22H32N2O5S
inchi: InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1
inchikey: HZEQBCVBILBTEP-ZFINNJDLSA-N
mass: 436.567
monoisotopicmass: 436.20319
has cross-reference: CAS:7280-37-7
has cross-reference: KEGG:D00948
alternative_term: Estropipate
has_obo_namespace: chebi_ontology
has_related_synonym: Piperazine estrone sulfate
id: CHEBI:4873
in subset: 2 STAR

cholinergic antagonist
type: Class
subclass of: cholinergic drug
textual definition: Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Anticholinergika
has_related_synonym: Anticholinergikum
has_related_synonym: acetylcholine antagonists
has_related_synonym: acetylcholine receptor antagonist
has_related_synonym: agent anticholinergique
has_related_synonym: agente anticolinergico
has_related_synonym: agentes anticolinergicos
has_related_synonym: anticholinergic agents
has_related_synonym: anticholinergics
has_related_synonym: anticholinergiques
has_related_synonym: anticolinergicos
has_related_synonym: cholinergic-blocking agents
id: CHEBI:48873
in subset: 3 STAR

muscarinic antagonist
type: Class
subclass of: cholinergic antagonist
textual definition: A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Antimuskarinika
has_related_synonym: Antimuskarinikum
has_related_synonym: agente antimuscarinico
has_related_synonym: agentes antimuscarinicos
has_related_synonym: agents antimuscariniques
has_related_synonym: antimuscarinic agents
has_related_synonym: antimuscarinicos
has_related_synonym: muscarinic acetylcholine receptor antagonist
has_related_synonym: muscarinic antagonists
id: CHEBI:48876
in subset: 3 STAR

nicotinic antagonist
type: Class
subclass of: cholinergic antagonist
textual definition: An antagonist at the nicotinic cholinergic receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Nicotinic_antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: agente antinicotinico
has_related_synonym: agentes antinicotinicos
has_related_synonym: agents antinicotiniques
has_related_synonym: antinicotinicos
has_related_synonym: nicotinic acetylcholine receptor antagonist
has_related_synonym: nicotinic acetylcholine receptor antagonists
has_related_synonym: nicotinic antagonists
has_related_synonym: nicotinic cholinergic antagonist
has_related_synonym: nicotinic cholinergic antagonists
id: CHEBI:48878
in subset: 3 STAR

bile acid metabolite
type: Class
subclass of: metabolite
textual definition: Metabolites of bile acids, four-ringed steroid acids formed along the cholesterol degradation pathway.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bile acid metabolites
has_related_synonym: bile salt metabolite
id: CHEBI:48887
in subset: 3 STAR

hormone antagonist
type: Class
subclass of: antagonist
subclass of: hormone receptor modulator
textual definition: A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hormone antagonists
id: CHEBI:49020
in subset: 3 STAR

prostaglandin antagonist
type: Class
subclass of: hormone antagonist
textual definition: A compound that inhibits the action of prostaglandins.
imported from: chebi.owl
has cross-reference: Wikipedia:Prostaglandin_antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: prostaglandin inhibitor
id: CHEBI:49023
in subset: 3 STAR

drug metabolite
type: Class
subclass of: human xenobiotic metabolite
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: drug metabolites
id: CHEBI:49103
in subset: 3 STAR

peripheral nervous system drug
type: Class
subclass of: drug
textual definition: A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: peripheral nervous system agent
has_related_synonym: peripheral nervous system drugs
id: CHEBI:49110
in subset: 3 STAR

leukotriene antagonist
type: Class
subclass of: hormone antagonist
textual definition: A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: LTRA
has_related_synonym: leukotriene antagonists
has_related_synonym: leukotriene receptor antagonist
has_related_synonym: leukotriene receptor antagonists
id: CHEBI:49159
in subset: 3 STAR

anti-asthmatic drug
type: Class
subclass of: drug
subclass of: anti-asthmatic agent
textual definition: A drug used to treat asthma.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-asthmatic agent
has_related_synonym: anti-asthmatic agents
has_related_synonym: anti-asthmatic drugs
id: CHEBI:49167
in subset: 3 STAR

EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
textual definition: An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that inhibits H(+)/K(+)-exchanging ATPase, EC 3.6.3.10. Such compounds are also known as proton pump inhibitors.
imported from: chebi.owl
has cross-reference: Wikipedia:Proton_pump_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: (K(+) + H(+))-ATPase inhibitor
has_related_synonym: (K(+) + H(+))-ATPase inhibitors
has_related_synonym: ATP phosphohydrolase (H(+)/K(+)-exchanging) inhibitor
has_related_synonym: ATP phosphohydrolase (H(+)/K(+)-exchanging) inhibitors
has_related_synonym: EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitors
has_related_synonym: EC 3.6.3.10 inhibitor
has_related_synonym: EC 3.6.3.10 inhibitors
has_related_synonym: H(+)-K(+)-ATPase inhibitor
has_related_synonym: H(+)-K(+)-ATPase inhibitors
has_related_synonym: H(+)/K(+)-ATPase inhibitor
has_related_synonym: H(+)/K(+)-ATPase inhibitors
has_related_synonym: H(+)/K(+)-exchanging ATPase inhibitor
has_related_synonym: H(+)/K(+)-exchanging ATPase inhibitors
has_related_synonym: H,K-ATPase inhibitor
has_related_synonym: H,K-ATPase inhibitors
has_related_synonym: proton pump inhibitor
has_related_synonym: proton pump inhibitors
id: CHEBI:49200
in subset: 3 STAR

anti-ulcer drug
type: Class
subclass of: drug
textual definition: One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-ulcer agent
has_related_synonym: anti-ulcer agents
has_related_synonym: anti-ulcer drugs
id: CHEBI:49201
in subset: 3 STAR

CETP inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of cholesterylester transfer protein (CETP), which transfers cholesterol from high density lipoproteins (HDL, the 'good' cholesterol-containing particles) to low or very low density lipoproteins (LDL or VLDL, the 'bad' cholesterol-containing particles). Inhibition of this process results in higher HDL levels and lower LDL levels. CETP inhibitors are under investigation as potential drugs to reduce the risk of arteriosclerotic vascular disease (atherosclerosis).
imported from: chebi.owl
has cross-reference: Wikipedia:CETP_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: CETP inhibitors
has_related_synonym: cholesteryl ester transfer protein inhibitor
id: CHEBI:49205
in subset: 3 STAR

contraceptive drug
type: Class
subclass of: reproductive control drug
textual definition: A chemical substance that prevents or reduces the probability of conception.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: contraceptive agent
has_related_synonym: contraceptive drugs
id: CHEBI:49323
in subset: 3 STAR

female contraceptive drug
type: Class
subclass of: contraceptive drug
textual definition: A chemical substance or agent with contraceptive activity in females.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: female contraceptive agent
has_related_synonym: female contraceptive drugs
id: CHEBI:49324
in subset: 3 STAR

oral contraceptive
type: Class
subclass of: female contraceptive drug
textual definition: A compound, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: oral contraceptives
id: CHEBI:49325
in subset: 3 STAR

synthetic oral contraceptive
type: Class
subclass of: oral contraceptive
textual definition: An oral contraceptive which owes its effectiveness to synthetic preparation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: synthetic oral contraceptives
id: CHEBI:49326
in subset: 3 STAR

excitatory amino acid agonist
type: Class
subclass of: neurotransmitter agent
textual definition: An agent that binds to and activates excitatory amino acid receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: excitatory amino acid agonists
has_related_synonym: excitatory amino acid receptor agonist
has_related_synonym: excitatory amino acid receptor agonists
id: CHEBI:50103
in subset: 3 STAR

sex hormone
type: Class
subclass of: hormone
textual definition: Any hormone that is responsible for controlling sexual characteristics and reproductive function.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Geschlechtshormon
has_related_synonym: Geschlechtshormone
has_related_synonym: Sexualhormon
has_related_synonym: Sexualhormone
has_related_synonym: hormone sexuelle
has_related_synonym: hormones sexuelles
has_related_synonym: sex hormones
id: CHEBI:50112
in subset: 3 STAR

androgen
type: Class
subclass of: sex hormone
textual definition: A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
imported from: chebi.owl
alternative_term: Androgen
has_obo_namespace: chebi_ontology
has_related_synonym: Androgene
has_related_synonym: androgene
has_related_synonym: androgenes
has_related_synonym: androgeno
has_related_synonym: androgenos
has_related_synonym: androgens
id: CHEBI:50113
in subset: 3 STAR

estrogen
type: Class
subclass of: sex hormone
textual definition: A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
imported from: chebi.owl
has cross-reference: Wikipedia:Estrogen
has_obo_namespace: chebi_ontology
has_related_synonym: Estrogene
has_related_synonym: Oestrogen
has_related_synonym: Oestrogene
has_related_synonym: estrogene
has_related_synonym: estrogenes
has_related_synonym: estrogenes Hormon
has_related_synonym: estrogeno
has_related_synonym: estrogenos
has_related_synonym: estrogens
has_related_synonym: oestrogen
has_related_synonym: oestrogene
has_related_synonym: oestrogenes
has_related_synonym: oestrogens
id: CHEBI:50114
in subset: 3 STAR

mu-opioid receptor antagonist
type: Class
subclass of: mu-opioid agent
subclass of: opioid receptor antagonist
textual definition: Any compound that exhibits antagonist activity at the mu-opioid receptor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mu-opioid antagonist
has_related_synonym: mu-opioid antagonists
has_related_synonym: mu-opioid receptor antagonists
id: CHEBI:50137
in subset: 3 STAR

bronchoconstrictor agent
type: Class
subclass of: drug
textual definition: A drug which causes a narrowing of the lumen of a bronchus or bronchiole.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bronchoconstrictor agents
has_related_synonym: bronchoconstrictor drug
id: CHEBI:50141
in subset: 3 STAR

keratolytic drug
type: Class
subclass of: dermatologic drug
textual definition: A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: desquamating agent
has_related_synonym: keratolytic agent
has_related_synonym: keratolytic drugs
has_related_synonym: skin-peeling agent
id: CHEBI:50176
in subset: 3 STAR

dermatologic drug
type: Class
subclass of: drug
textual definition: A drug used to treat or prevent skin disorders or for the routine care of skin.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: dermatologic agent
has_related_synonym: dermatologic drugs
has_related_synonym: dermatological agent
id: CHEBI:50177
in subset: 3 STAR

P450 inhibitor
type: Class
subclass of: EC 1.14.14.1 (unspecific monooxygenase) inhibitor
textual definition: An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CYP2D6 inhibitor
has_related_synonym: CYP2D6 inhibitors
has_related_synonym: P450 inhibitors
has_related_synonym: cytochrome P450 inhibitor
has_related_synonym: cytochrome P450 inhibitors
id: CHEBI:50183
in subset: 3 STAR

ion transport inhibitor
type: Class
subclass of: membrane transport modulator
textual definition: A compound which inhibits the movement of an ion across an energy-transducing cell membrane.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ion transport inhibitors
has_related_synonym: ion-transport inhibitor
has_related_synonym: ion-transport inhibitors
id: CHEBI:50184
in subset: 3 STAR

fatty acid synthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: Any pathway inhibitor that inhibits the synthesis of fatty acids.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fatty acid synthesis inhibitors
id: CHEBI:50185
in subset: 3 STAR

provitamin
type: Class
subclass of: biological role
textual definition: A substance that can be converted into a vitamin by animal tissues.
imported from: chebi.owl
has cross-reference: Wikipedia:Provitamin
has_obo_namespace: chebi_ontology
has_related_synonym: provitamins
id: CHEBI:50188
in subset: 3 STAR

EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
textual definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a phosphoric diester hydrolase (EC 3.1.4.*).
imported from: chebi.owl
has_alternative_id: CHEBI:76774
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.4.* (phosphoric diester hydrolase) inhibitors
has_related_synonym: phosphodiesterase inhibitor
has_related_synonym: phosphodiesterase inhibitors
has_related_synonym: phosphoric diester hydrolase (EC 3.1.4.*) inhibitor
has_related_synonym: phosphoric diester hydrolase (EC 3.1.4.*) inhibitors
has_related_synonym: phosphoric diester hydrolase inhibitor
has_related_synonym: phosphoric diester hydrolase inhibitors
id: CHEBI:50218
in subset: 3 STAR

cholinesterase reactivator
type: Class
subclass of: enzyme reactivator
textual definition: A drug used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cholinesterase reactivators
id: CHEBI:50241
in subset: 3 STAR

enzyme reactivator
type: Class
subclass of: biochemical role
textual definition: Compound which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.
imported from: chebi.owl
has cross-reference: PMID:15551381
has cross-reference: PMID:16763789
has cross-reference: PMID:8415873
has_obo_namespace: chebi_ontology
has_related_synonym: enzyme reactivators
id: CHEBI:50242
in subset: 3 STAR

antidote
type: Class
subclass of: protective agent
textual definition: Any protective agent counteracting or neutralizing the action of poisons.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidotes
id: CHEBI:50247
in subset: 3 STAR

hematologic agent
type: Class
subclass of: drug
textual definition: Drug that acts on blood and blood-forming organs and those that affect the hemostatic system.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hematologic agents
id: CHEBI:50248
in subset: 3 STAR

anticoagulant
type: Class
subclass of: hematologic agent
textual definition: An agent that prevents blood clotting.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anticoagulante
has_related_synonym: anticoagulants
id: CHEBI:50249
in subset: 3 STAR

prodrug
type: Class
subclass of: pro-agent
subclass of: drug
textual definition: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
imported from: chebi.owl
has cross-reference: PMID:23993918
has cross-reference: PMID:23998799
has cross-reference: PMID:24329110
has cross-reference: PMID:24628402
has cross-reference: PMID:24709544
has cross-reference: PMID:25144792
has cross-reference: PMID:25157234
has cross-reference: PMID:25269430
has cross-reference: PMID:25391982
has cross-reference: PMID:25591121
has cross-reference: PMID:25620096
has cross-reference: PMID:25795057
has cross-reference: PMID:26028253
has cross-reference: PMID:26184144
has cross-reference: PMID:28070577
has cross-reference: PMID:28215138
has cross-reference: PMID:28219047
has cross-reference: PMID:28259775
has cross-reference: PMID:28319647
has cross-reference: PMID:28329729
has cross-reference: PMID:28334528
has cross-reference: Wikipedia:Prodrug
has_obo_namespace: chebi_ontology
has_related_synonym: Prodrugs
id: CHEBI:50266
in subset: 3 STAR

protective agent
type: Class
subclass of: drug
textual definition: Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: chemoprotectant
has_related_synonym: chemoprotectants
has_related_synonym: chemoprotective agent
has_related_synonym: chemoprotective agents
has_related_synonym: protective agents
id: CHEBI:50267
in subset: 3 STAR

GABA modulator
type: Class
subclass of: membrane transport modulator
subclass of: GABA agent
textual definition: A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GABA modulators
id: CHEBI:50268
in subset: 3 STAR

EC 1.1.1.1 (alcohol dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of alcohol dehydrogenase (EC 1.1.1.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Alcohol_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: ADH inhibitor
has_related_synonym: ADH inhibitors
has_related_synonym: EC 1.1.1.1 (alcohol dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.1 inhibitor
has_related_synonym: EC 1.1.1.1 inhibitors
has_related_synonym: NAD-dependent alcohol dehydrogenase inhibitor
has_related_synonym: NAD-dependent alcohol dehydrogenase inhibitors
has_related_synonym: NAD-specific aromatic alcohol dehydrogenase inhibitor
has_related_synonym: NAD-specific aromatic alcohol dehydrogenase inhibitors
has_related_synonym: NADH-alcohol dehydrogenase inhibitor
has_related_synonym: NADH-alcohol dehydrogenase inhibitors
has_related_synonym: NADH-aldehyde dehydrogenase inhibitor
has_related_synonym: NADH-aldehyde dehydrogenase inhibitors
has_related_synonym: alcohol dehydrogenase (EC 1.1.1.1) inhibitor
has_related_synonym: alcohol dehydrogenase (EC 1.1.1.1) inhibitors
has_related_synonym: alcohol dehydrogenase (NAD) inhibitor
has_related_synonym: alcohol dehydrogenase (NAD) inhibitors
has_related_synonym: alcohol dehydrogenase inhibitor
has_related_synonym: alcohol dehydrogenase inhibitors
has_related_synonym: alcohol:NAD+ oxidoreductase inhibitor
has_related_synonym: alcohol:NAD+ oxidoreductase inhibitors
has_related_synonym: aldehyde reductase inhibitor
has_related_synonym: aldehyde reductase inhibitors
has_related_synonym: aliphatic alcohol dehydrogenase inhibitor
has_related_synonym: aliphatic alcohol dehydrogenase inhibitors
has_related_synonym: ethanol dehydrogenase inhibitor
has_related_synonym: ethanol dehydrogenase inhibitors
has_related_synonym: primary alcohol dehydrogenase inhibitor
has_related_synonym: primary alcohol dehydrogenase inhibitors
has_related_synonym: yeast alcohol dehydrogenase inhibitor
has_related_synonym: yeast alcohol dehydrogenase inhibitors
id: CHEBI:50269
in subset: 3 STAR

esomeprazole
type: Class
subclass of: molecular entity
textual definition: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium salt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.
imported from: chebi.owl
charge: 0
formula: C17H19N3O3S
inchi: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m0/s1
inchikey: SUBDBMMJDZJVOS-DEOSSOPVSA-N
mass: 345.41600
monoisotopicmass: 345.11471
has cross-reference: CAS:119141-88-7
has cross-reference: DrugBank:DB00736
has cross-reference: Drug_Central:1055
has cross-reference: HMDB:HMDB0005009
has cross-reference: HMDB:HMDB0014874
has cross-reference: KEGG:D07917
has cross-reference: PMID:10983736
has cross-reference: PMID:15080761
has cross-reference: PMID:18407713
has cross-reference: PMID:18472988
has cross-reference: PMID:23677700
has cross-reference: Reaxys:12060639
has cross-reference: Wikipedia:Esomeprazole
alternative_term: 5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
has_obo_namespace: chebi_ontology
has_related_synonym: (-)-omeprazole
has_related_synonym: (S)-(-)-omeprazole
has_related_synonym: (S)-omeprazole
has_related_synonym: Alenia
has_related_synonym: Escz
has_related_synonym: Esofag
has_related_synonym: Inexium paranova
has_related_synonym: esomeprazol
has_related_synonym: esomeprazole
has_related_synonym: esomeprazolum
id: CHEBI:50275
in subset: 3 STAR

EC 5.99.1.2 (DNA topoisomerase) inhibitor
type: Class
subclass of: topoisomerase inhibitor
textual definition: A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: DNA topoisomerase inhibitor
has_related_synonym: DNA topoisomerase inhibitors
has_related_synonym: EC 5.99.1.2 (DNA topoisomerase) inhibitors
has_related_synonym: EC 5.99.1.2 (topoisomerase I) inhibitor
has_related_synonym: EC 5.99.1.2 (topoisomerase I) inhibitors
has_related_synonym: EC 5.99.1.2 inhibitor
has_related_synonym: EC 5.99.1.2 inhibitors
has_related_synonym: topoisomerase I (EC 5.99.1.2) inhibitor
has_related_synonym: topoisomerase I (EC 5.99.1.2) inhibitors
has_related_synonym: topoisomerase I inhibitor
has_related_synonym: topoisomerase I inhibitors
has_related_synonym: type I DNA topoisomerase inhibitor
has_related_synonym: type I DNA topoisomerase inhibitors
id: CHEBI:50276
in subset: 3 STAR

parasympatholytic
type: Class
subclass of: cholinergic antagonist
textual definition: Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: parasympatholytics
id: CHEBI:50370
in subset: 3 STAR

EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the activity of ceramide glucosyltransferase (EC 2.4.1.80).
imported from: chebi.owl
has_alternative_id: CHEBI:75128
has cross-reference: PMID:19285492
has cross-reference: PMID:21974949
has cross-reference: PMID:22918683
has cross-reference: Wikipedia:Ceramide_glucosyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.80 (ceramide glucosyltransferase) inhibitors
has_related_synonym: EC 2.4.1.80 inhibitor
has_related_synonym: EC 2.4.1.80 inhibitors
has_related_synonym: UDP-glucose:N-acylsphingosine D-glucosyltransferase inhibitor
has_related_synonym: UDP-glucose:N-acylsphingosine D-glucosyltransferase inhibitors
has_related_synonym: UDP-glucose:ceramide glucosyltransferase inhibitor
has_related_synonym: UDP-glucose:ceramide glucosyltransferase inhibitors
has_related_synonym: ceramide glucosyltransferase (EC 2.4.1.80) inhibitor
has_related_synonym: ceramide glucosyltransferase (EC 2.4.1.80) inhibitors
has_related_synonym: ceramide glucosyltransferase inhibitor
has_related_synonym: ceramide glucosyltransferase inhibitors
has_related_synonym: ceramide:UDP-glucose glucosyltransferase inhibitor
has_related_synonym: ceramide:UDP-glucose glucosyltransferase inhibitors
has_related_synonym: ceramide:UDPGlc glucosyltransferase inhibitor
has_related_synonym: ceramide:UDPGlc glucosyltransferase inhibitors
has_related_synonym: glucosylceramide synthase inhibitor
has_related_synonym: glucosylceramide synthase inhibitors
has_related_synonym: uridine diphosphoglucose-ceramide glucosyltransferase inhibitor
has_related_synonym: uridine diphosphoglucose-ceramide glucosyltransferase inhibitors
id: CHEBI:50382
in subset: 3 STAR

EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor
type: Class
subclass of: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor
textual definition: An EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor that interferes with the action of NAD(P)H dehydrogenase (quinone), EC 1.6.5.2.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: DT diaphorase inhibitor
has_related_synonym: EC 1.6.5.2 (NAD(P)H dehydrogenase (quinone)) inhibitor
has_related_synonym: EC 1.6.5.2 (NAD(P)H dehydrogenase (quinone)) inhibitors
has_related_synonym: EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitors
has_related_synonym: EC 1.6.5.2 inhibitor
has_related_synonym: EC 1.6.5.2 inhibitors
has_related_synonym: NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) inhibitor
has_related_synonym: NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) inhibitors
has_related_synonym: NAD(P)H dehydrogenase (quinone) inhibitor
has_related_synonym: NAD(P)H dehydrogenase (quinone) inhibitors
has_related_synonym: NAD(P)H dehydrogenase inhibitor
has_related_synonym: NAD(P)H dehydrogenase inhibitors
has_related_synonym: NAD(P)H menadione reductase inhibitor
has_related_synonym: NAD(P)H menadione reductase inhibitors
has_related_synonym: NAD(P)H-quinone dehydrogenase inhibitor
has_related_synonym: NAD(P)H-quinone dehydrogenase inhibitors
has_related_synonym: NAD(P)H-quinone oxidoreductase inhibitor
has_related_synonym: NAD(P)H-quinone oxidoreductase inhibitors
has_related_synonym: NAD(P)H2 dehydrogenase (quinone) inhibitor
has_related_synonym: NAD(P)H2 dehydrogenase (quinone) inhibitors
has_related_synonym: NAD(P)H: menadione oxidoreductase inhibitor
has_related_synonym: NAD(P)H: menadione oxidoreductase inhibitors
has_related_synonym: NAD(P)H:(quinone-acceptor)oxidoreductase inhibitor
has_related_synonym: NAD(P)H:(quinone-acceptor)oxidoreductase inhibitors
has_related_synonym: NAD(P)H:quinone oxidoreductase inhibitor
has_related_synonym: NAD(P)H:quinone oxidoreductase inhibitors
has_related_synonym: NADH-menadione reductase inhibitor
has_related_synonym: NADH-menadione reductase inhibitors
has_related_synonym: NQO1 inhibitor
has_related_synonym: NQO1 inhibitors
has_related_synonym: QR1 inhibitor
has_related_synonym: QR1 inhibitors
has_related_synonym: dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) inhibitor
has_related_synonym: dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) inhibitors
has_related_synonym: diaphorase inhibitor
has_related_synonym: diaphorase inhibitors
has_related_synonym: flavoprotein NAD(P)H-quinone reductase inhibitor
has_related_synonym: flavoprotein NAD(P)H-quinone reductase inhibitors
has_related_synonym: menadione oxidoreductase inhibitor
has_related_synonym: menadione oxidoreductase inhibitors
has_related_synonym: menadione reductase inhibitor
has_related_synonym: menadione reductase inhibitors
has_related_synonym: naphthoquinone reductase inhibitor
has_related_synonym: naphthoquinone reductase inhibitors
has_related_synonym: p-benzoquinone reductase inhibitor
has_related_synonym: p-benzoquinone reductase inhibitors
has_related_synonym: phylloquinone reductase inhibitor
has_related_synonym: phylloquinone reductase inhibitors
has_related_synonym: quinone reductase inhibitor
has_related_synonym: quinone reductase inhibitors
has_related_synonym: reduced NAD(P)H dehydrogenase inhibitor
has_related_synonym: reduced NAD(P)H dehydrogenase inhibitors
has_related_synonym: reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase inhibitor
has_related_synonym: reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase inhibitors
has_related_synonym: viologen accepting pyridine nucleotide oxidoreductase inhibitor
has_related_synonym: viologen accepting pyridine nucleotide oxidoreductase inhibitors
has_related_synonym: vitamin K reductase inhibitor
has_related_synonym: vitamin K reductase inhibitors
has_related_synonym: vitamin-K reductase inhibitor
has_related_synonym: vitamin-K reductase inhibitors
id: CHEBI:50390
in subset: 3 STAR

probe
type: Class
subclass of: application
textual definition: A role played by a molecular entity used to study the microscopic environment.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50406
in subset: 3 STAR

acid-base indicator
type: Class
subclass of: colour indicator
textual definition: An acid or base which exhibits a colour change on neutralization by the basic or acidic titrant at or near the equivalence point of a titration.
imported from: chebi.owl
alternative_term: acid-base indicator
has_obo_namespace: chebi_ontology
has_related_synonym: Saeure-Base-Indikator
has_related_synonym: Saeure-Base-Indikatoren
has_related_synonym: indicador acido-base
has_related_synonym: indicateur acide-base
id: CHEBI:50407
in subset: 3 STAR

visual indicator
type: Class
subclass of: indicator
textual definition: Anything used in a scientific experiment that gives a visual change to indicate the presence of a substance or quality, change in a body, etc.
imported from: chebi.owl
alternative_term: visual indicator
has_obo_namespace: chebi_ontology
has_related_synonym: indicador visual
has_related_synonym: indicateur visuel
id: CHEBI:50408
in subset: 3 STAR

adsorption indicator
type: Class
subclass of: visual indicator
textual definition: A substance which is adsorbed or desorbed with concomitant colour change at or near the equivalence point of a titration.
imported from: chebi.owl
alternative_term: adsorption indicator
has_obo_namespace: chebi_ontology
has_related_synonym: indicador de adsorcion
has_related_synonym: indicateur par adsorption
id: CHEBI:50409
in subset: 3 STAR

colour indicator
type: Class
subclass of: visual indicator
imported from: chebi.owl
alternative_term: colour indicator
has_obo_namespace: chebi_ontology
has_related_synonym: indicador de color
has_related_synonym: indicateur colore
has_related_synonym: indicateurs colores
id: CHEBI:50410
in subset: 3 STAR

one-colour indicator
type: Class
subclass of: colour indicator
textual definition: A colour indicator that is colourless on one side of the transition interval.
imported from: chebi.owl
alternative_term: one-colour indicator
has_obo_namespace: chebi_ontology
has_related_synonym: indicador monocolor
has_related_synonym: indicador monocromico
has_related_synonym: indicateur monocolore
id: CHEBI:50411
in subset: 3 STAR

two-colour indicator
type: Class
subclass of: colour indicator
textual definition: A colour indicator that possesses a different colour on each side of the transition interval.
imported from: chebi.owl
alternative_term: two-colour indicator
has_obo_namespace: chebi_ontology
has_related_synonym: indicador bicolor
has_related_synonym: indicateur bicolore
id: CHEBI:50412
in subset: 3 STAR

EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor
type: Class
subclass of: EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor
textual definition: An EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor that interferes with the action of NAD(P)H oxidase (H2O2-forming), EC 1.6.3.1.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.6.3.1 inhibitor
has_related_synonym: EC 1.6.3.1 inhibitors
has_related_synonym: EC 1.6.3.1. (NAD(P)H oxidase (H2O2-forming)) inhibitor
has_related_synonym: EC 1.6.3.1. (NAD(P)H oxidase (H2O2-forming)) inhibitors
has_related_synonym: EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitors
has_related_synonym: NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) inhibitor
has_related_synonym: NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) inhibitors
has_related_synonym: NAD(P)H oxidase (H2O2-forming) inhibitor
has_related_synonym: NAD(P)H oxidase (H2O2-forming) inhibitors
has_related_synonym: NAD(P)H oxidase inhibitor
has_related_synonym: NAD(P)H oxidase inhibitors
has_related_synonym: NAD(P)H:oxygen oxidoreductase (H2O2-forming) inhibitor
has_related_synonym: NAD(P)H:oxygen oxidoreductase (H2O2-forming) inhibitors
has_related_synonym: NAD(P)H:oxygen oxidoreductase inhibitor
has_related_synonym: NAD(P)H:oxygen oxidoreductase inhibitors
has_related_synonym: NADPH oxidase inhibitor
has_related_synonym: NADPH oxidase inhibitors
has_related_synonym: THOX2 inhibitor
has_related_synonym: THOX2 inhibitors
has_related_synonym: ThOX inhibitor
has_related_synonym: ThOX inhibitors
has_related_synonym: dual oxidase inhibitor
has_related_synonym: dual oxidase inhibitors
has_related_synonym: p138tox inhibitor
has_related_synonym: p138tox inhibitors
has_related_synonym: thyroid NADPH oxidase inhibitor
has_related_synonym: thyroid NADPH oxidase inhibitors
has_related_synonym: thyroid oxidase 2 inhibitor
has_related_synonym: thyroid oxidase 2 inhibitors
has_related_synonym: thyroid oxidase inhibitor
has_related_synonym: thyroid oxidase inhibitors
id: CHEBI:50423
in subset: 3 STAR

platelet aggregation inhibitor
type: Class
subclass of: hematologic agent
textual definition: A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: platelet aggregation inhibitors
id: CHEBI:50427
in subset: 3 STAR

platelet glycoprotein-IIb/IIIa receptor antagonist
type: Class
subclass of: antagonist
subclass of: platelet aggregation inhibitor
textual definition: Antagonist of platelet surface glycoprotein-IIb/IIIa which has a key role in hemostasis and thrombosis such as platelet adhesion and aggregation.
imported from: chebi.owl
has cross-reference: Wikipedia:Glycoprotein_IIb/IIIa_inhibitors
has_obo_namespace: chebi_ontology
has_related_synonym: GPIIb/IIIa antagonist
has_related_synonym: GPIIb/IIIa antagonists
has_related_synonym: fibrinogen receptor antagonist
has_related_synonym: fibrinogen receptor antagonists
has_related_synonym: glycoprotein-IIb/IIIa receptor antagonist
has_related_synonym: glycoprotein-IIb/IIIa receptor antagonists
has_related_synonym: platelet glycoprotein-IIb/IIIa receptor antagonists
id: CHEBI:50433
in subset: 3 STAR

adenosine phosphodiesterase inhibitor
type: Class
subclass of: EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50444
in subset: 3 STAR

EC 3.5.4.4 (adenosine deaminase) inhibitor
type: Class
subclass of: EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor
textual definition: An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of adenosine deaminase (EC 3.5.4.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_deaminase
has_obo_namespace: chebi_ontology
has_related_synonym: ADA inhibitor
has_related_synonym: EC 3.5.4.4 (adenosine deaminase) inhibitors
has_related_synonym: EC 3.5.4.4 inhibitor
has_related_synonym: EC 3.5.4.4 inhibitors
has_related_synonym: adenosine aminohydrolase inhibitor
has_related_synonym: adenosine aminohydrolase inhibitors
has_related_synonym: adenosine deaminase (EC 3.5.4.4) inhibitor
has_related_synonym: adenosine deaminase (EC 3.5.4.4) inhibitors
has_related_synonym: adenosine deaminase inhibitor
has_related_synonym: adenosine deaminase inhibitors
has_related_synonym: deoxyadenosine deaminase inhibitor
has_related_synonym: deoxyadenosine deaminase inhibitors
id: CHEBI:50445
in subset: 3 STAR

EC 3.1.1.4 (phospholipase A2) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
textual definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of phospholipase A2 (EC 3.1.1.4).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.1.4 (phospholipase A2) inhibitors
has_related_synonym: EC 3.1.1.4 inhibitor
has_related_synonym: EC 3.1.1.4 inhibitors
has_related_synonym: lecithinase A inhibitor
has_related_synonym: lecithinase A inhibitors
has_related_synonym: phosphatidase inhibitor
has_related_synonym: phosphatidase inhibitors
has_related_synonym: phosphatidolipase inhibitor
has_related_synonym: phosphatidolipase inhibitors
has_related_synonym: phosphatidylcholine 2-acylhydrolase inhibitor
has_related_synonym: phosphatidylcholine 2-acylhydrolase inhibitors
has_related_synonym: phospholipase A inhibitor
has_related_synonym: phospholipase A inhibitors
has_related_synonym: phospholipase A2 (EC 3.1.1.4) inhibitor
has_related_synonym: phospholipase A2 (EC 3.1.1.4) inhibitors
has_related_synonym: phospholipase A2 inhibitor
has_related_synonym: phospholipase A2 inhibitors
id: CHEBI:50469
in subset: 3 STAR

EC 2.5.1.15 (dihydropteroate synthase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.
imported from: chebi.owl
has cross-reference: Wikipedia:Dihydropteroate_synthase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor
has_related_synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors
has_related_synonym: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor
has_related_synonym: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors
has_related_synonym: 7,8-dihydropteroate synthase inhibitor
has_related_synonym: 7,8-dihydropteroate synthase inhibitors
has_related_synonym: 7,8-dihydropteroate synthetase inhibitor
has_related_synonym: 7,8-dihydropteroate synthetase inhibitors
has_related_synonym: 7,8-dihydropteroic acid synthetase inhibitor
has_related_synonym: 7,8-dihydropteroic acid synthetase inhibitors
has_related_synonym: DHPS inhibitor
has_related_synonym: DHPS inhibitors
has_related_synonym: EC 2.5.1.15 (dihydropteroate synthase) inhibitors
has_related_synonym: EC 2.5.1.15 inhibitor
has_related_synonym: EC 2.5.1.15 inhibitors
has_related_synonym: dihydropteroate diphosphorylase inhibitor
has_related_synonym: dihydropteroate diphosphorylase inhibitors
has_related_synonym: dihydropteroate pyrophosphorylase inhibitor
has_related_synonym: dihydropteroate pyrophosphorylase inhibitors
has_related_synonym: dihydropteroate synthase (EC 2.5.1.15) inhibitor
has_related_synonym: dihydropteroate synthase (EC 2.5.1.15) inhibitors
has_related_synonym: dihydropteroate synthase inhibitor
has_related_synonym: dihydropteroate synthase inhibitors
has_related_synonym: dihydropteroate synthetase inhibitor
has_related_synonym: dihydropteroate synthetase inhibitors
has_related_synonym: dihydropteroic synthetase inhibitor
has_related_synonym: dihydropteroic synthetase inhibitors
id: CHEBI:50502
in subset: 3 STAR

laxative
type: Class
subclass of: drug
textual definition: An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: aperient
has_related_synonym: aperients
has_related_synonym: laxante
has_related_synonym: laxatives
has_related_synonym: purgative
has_related_synonym: purgatives
id: CHEBI:50503
in subset: 3 STAR

osmotic diuretic
type: Class
subclass of: diuretic
textual definition: Compound that increase urine volume by increasing the amount of osmotically active solute in the urine. It also increases the osmolarity of plasma.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50504
in subset: 3 STAR

sweetening agent
type: Class
subclass of: flavouring agent
textual definition: Substance that sweeten food, beverages, medications, etc.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sweetener
has_related_synonym: sweeteners
id: CHEBI:50505
in subset: 3 STAR

appetite depressant
type: Class
subclass of: appetite regulator
textual definition: Any agent that is used to decrease appetite.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: appetite suppressant
has_related_synonym: appetite suppressants
id: CHEBI:50507
in subset: 3 STAR

potassium channel blocker
type: Class
subclass of: potassium channel modulator
textual definition: An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50509
in subset: 3 STAR

potassium channel modulator
type: Class
subclass of: membrane transport modulator
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50510
in subset: 3 STAR

mydriatic agent
type: Class
subclass of: drug
textual definition: Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mydriatics
id: CHEBI:50513
in subset: 3 STAR

vasoconstrictor agent
type: Class
subclass of: cardiovascular drug
textual definition: Drug used to cause constriction of the blood vessels.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50514
in subset: 3 STAR

protein denaturant
type: Class
subclass of: application
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50533
in subset: 1 STAR

nitric oxide donor
type: Class
subclass of: donor
textual definition: An agent, with unique chemical structure and biochemical requirements, which generates nitric oxide.
imported from: chebi.owl
has_alternative_id: CHEBI:77704
has_obo_namespace: chebi_ontology
has_related_synonym: NO donor
has_related_synonym: NO donors
has_related_synonym: NO generator
has_related_synonym: NO generators
has_related_synonym: NO releasing agent
has_related_synonym: NO releasing agents
has_related_synonym: nitric oxide donors
has_related_synonym: nitric oxide generators
has_related_synonym: nitric oxide releasing agent
has_related_synonym: nitric oxide releasing agents
id: CHEBI:50566
in subset: 3 STAR

EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor
type: Class
subclass of: EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
textual definition: An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 3',5'-cyclic nucleoside monophosphate phosphodiesterase inhibitor
has_related_synonym: 3',5'-cyclic nucleoside monophosphate phosphodiesterase inhibitors
has_related_synonym: 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase inhibitor
has_related_synonym: 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase inhibitors
has_related_synonym: 3',5'-cyclic-nucleotide phosphodiesterase inhibitor
has_related_synonym: 3',5'-cyclic-nucleotide phosphodiesterase inhibitors
has_related_synonym: 3',5'-cyclonucleotide phosphodiesterase inhibitor
has_related_synonym: 3',5'-cyclonucleotide phosphodiesterase inhibitors
has_related_synonym: 3',5'-nucleotide phosphodiesterase inhibitor
has_related_synonym: 3',5'-nucleotide phosphodiesterase inhibitors
has_related_synonym: 3': 5'-monophosphate phosphodiesterase (cyclic CMP) inhibitor
has_related_synonym: 3': 5'-monophosphate phosphodiesterase (cyclic CMP) inhibitors
has_related_synonym: 3':5'-cyclic nucleotide 5'-nucleotidohydrolase inhibitor
has_related_synonym: 3':5'-cyclic nucleotide 5'-nucleotidohydrolase inhibitors
has_related_synonym: EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitors
has_related_synonym: EC 3.1.4.17 inhibitor
has_related_synonym: EC 3.1.4.17 inhibitors
has_related_synonym: PDE inhibitor
has_related_synonym: PDE inhibitors
has_related_synonym: cyclic 3',5'-mononucleotide phosphodiesterase inhibitor
has_related_synonym: cyclic 3',5'-mononucleotide phosphodiesterase inhibitors
has_related_synonym: cyclic 3',5'-nucleotide phosphodiesterase inhibitor
has_related_synonym: cyclic 3',5'-nucleotide phosphodiesterase inhibitors
has_related_synonym: cyclic 3',5'-phosphodiesterase inhibitor
has_related_synonym: cyclic 3',5'-phosphodiesterase inhibitors
has_related_synonym: cyclic 3',5-nucleotide monophosphate phosphodiesterase inhibitor
has_related_synonym: cyclic 3',5-nucleotide monophosphate phosphodiesterase inhibitors
has_related_synonym: cyclic AMP phosphodiesterase inhibitor
has_related_synonym: cyclic AMP phosphodiesterase inhibitors
has_related_synonym: cyclic nucleotide phosphodiesterase inhibitor
has_related_synonym: cyclic nucleotide phosphodiesterase inhibitors
has_related_synonym: cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) inhibitor
has_related_synonym: cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) inhibitors
has_related_synonym: nucleoside 3',5'-cyclic phosphate diesterase inhibitor
has_related_synonym: nucleoside 3',5'-cyclic phosphate diesterase inhibitors
has_related_synonym: nucleoside-3',5-monophosphate phosphodiesterase inhibitor
has_related_synonym: nucleoside-3',5-monophosphate phosphodiesterase inhibitors
has_related_synonym: phosphodiesterase III inhibitor
id: CHEBI:50568
in subset: 3 STAR

EC 3.2.1.1 (alpha-amylase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-amylase (EC 3.2.1.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Alpha-amylase
has_obo_namespace: chebi_ontology
has_related_synonym: 1,4-alpha-D-glucan glucanohydrolase inhibitor
has_related_synonym: 1,4-alpha-D-glucan glucanohydrolase inhibitors
has_related_synonym: 4-alpha-D-glucan glucanohydrolase inhibitor
has_related_synonym: 4-alpha-D-glucan glucanohydrolase inhibitors
has_related_synonym: EC 3.2.1.1 (alpha-amylase) inhibitors
has_related_synonym: EC 3.2.1.1 inhibitor
has_related_synonym: EC 3.2.1.1 inhibitors
has_related_synonym: Taka-amylase A inhibitor
has_related_synonym: Taka-amylase A inhibitors
has_related_synonym: alpha-amylase (EC 3.2.1.1) inhibitor
has_related_synonym: alpha-amylase (EC 3.2.1.1) inhibitors
has_related_synonym: alpha-amylase inhibitor
has_related_synonym: alpha-amylase inhibitors
has_related_synonym: endoamylase inhibitor
has_related_synonym: endoamylase inhibitors
has_related_synonym: glycogenase inhibitor
has_related_synonym: glycogenase inhibitors
id: CHEBI:50627
in subset: 3 STAR

cyclooxygenase 2 inhibitor
type: Class
subclass of: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
textual definition: A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
imported from: chebi.owl
has cross-reference: Wikipedia:Prostaglandin-endoperoxide_synthase_2
has_obo_namespace: chebi_ontology
has_related_synonym: COX-2 inhibitor
has_related_synonym: COX-2 inhibitors
has_related_synonym: PGHS-2 inhibitor
has_related_synonym: PGHS-2 inhibitors
has_related_synonym: cyclo-oxygenase 2 inhibitor
has_related_synonym: cyclo-oxygenase 2 inhibitors
has_related_synonym: cyclo-oxygenase-2 inhibitor
has_related_synonym: cyclo-oxygenase-2 inhibitors
has_related_synonym: cyclooxygenase 2 inhibitors
has_related_synonym: cyclooxygenase-2 inhibitor
has_related_synonym: cyclooxygenase-2 inhibitors
has_related_synonym: prostaglandin H synthase-2 inhibitor
has_related_synonym: prostaglandin H synthase-2 inhibitors
has_related_synonym: prostaglandin-endoperoxide synthase 2 inhibitor
has_related_synonym: prostaglandin-endoperoxide synthase 2 inhibitors
id: CHEBI:50629
in subset: 3 STAR

cyclooxygenase 1 inhibitor
type: Class
subclass of: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
textual definition: A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
imported from: chebi.owl
has cross-reference: Wikipedia:PTGS1
has_obo_namespace: chebi_ontology
has_related_synonym: COX-1 inhibitor
has_related_synonym: COX-1 inhibitors
has_related_synonym: PTGS1 inhibitor
has_related_synonym: PTGS1 inhibitors
has_related_synonym: cyclo-oxygenase 1 inhibitor
has_related_synonym: cyclo-oxygenase 1 inhibitors
has_related_synonym: cyclooxygenase 1 inhibitors
has_related_synonym: cyclooxygenase-1 inhibitor
has_related_synonym: cyclooxygenase-1 inhibitors
has_related_synonym: prostaglandin G/H synthase 1 inhibitor
has_related_synonym: prostaglandin G/H synthase 1 inhibitors
has_related_synonym: prostaglandin H2 synthase 1 inhibitor
has_related_synonym: prostaglandin H2 synthase 1 inhibitors
has_related_synonym: prostaglandin-endoperoxide synthase 1 inhibitor
has_related_synonym: prostaglandin-endoperoxide synthase 1 inhibitors
id: CHEBI:50630
in subset: 3 STAR

EC 3.5.1.5 (urease) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of urease (EC 3.5.1.5), reducing hydrolysis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.5 (urease) inhibitors
has_related_synonym: EC 3.5.1.5 inhibitor
has_related_synonym: EC 3.5.1.5 inhibitors
has_related_synonym: urea amidohydrolase inhibitor
has_related_synonym: urea amidohydrolase inhibitors
has_related_synonym: urease (EC 3.5.1.5) inhibitor
has_related_synonym: urease (EC 3.5.1.5) inhibitors
has_related_synonym: urease inhibitor
has_related_synonym: urease inhibitors
id: CHEBI:50635
in subset: 3 STAR

EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dimethylallyltranstransferase (EC 2.5.1.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Dimethylallyltranstransferase
has_obo_namespace: chebi_ontology
has_related_synonym: (2E,6E)-farnesyl diphosphate synthetase inhibitor
has_related_synonym: (2E,6E)-farnesyl diphosphate synthetase inhibitors
has_related_synonym: DMAPP:IPP-dimethylallyltransferase inhibitor
has_related_synonym: DMAPP:IPP-dimethylallyltransferase inhibitors
has_related_synonym: EC 2.5.1.1 (dimethylallyltranstransferase) inhibitors
has_related_synonym: EC 2.5.1.1 inhibitor
has_related_synonym: EC 2.5.1.1 inhibitors
has_related_synonym: dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase inhibitor
has_related_synonym: dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase inhibitors
has_related_synonym: dimethylallyltransferase inhibitor
has_related_synonym: dimethylallyltransferase inhibitors
has_related_synonym: dimethylallyltranstransferase (EC 2.5.1.1) inhibitor
has_related_synonym: dimethylallyltranstransferase (EC 2.5.1.1) inhibitors
has_related_synonym: dimethylallyltranstransferase inhibitor
has_related_synonym: dimethylallyltranstransferase inhibitors
has_related_synonym: diprenyltransferase inhibitor
has_related_synonym: diprenyltransferase inhibitors
has_related_synonym: geranyl pyrophosphate synthase inhibitor
has_related_synonym: geranyl pyrophosphate synthase inhibitors
has_related_synonym: geranyl pyrophosphate synthetase inhibitor
has_related_synonym: geranyl pyrophosphate synthetase inhibitors
has_related_synonym: geranyl-diphosphate synthase inhibitor
has_related_synonym: geranyl-diphosphate synthase inhibitors
has_related_synonym: prenyltransferase inhibitor
has_related_synonym: prenyltransferase inhibitors
has_related_synonym: trans-farnesyl pyrophosphate synthetase inhibitor
has_related_synonym: trans-farnesyl pyrophosphate synthetase inhibitors
id: CHEBI:50643
in subset: 3 STAR

bone density conservation agent
type: Class
subclass of: drug
textual definition: An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
imported from: chebi.owl
has_alternative_id: CHEBI:72497
has cross-reference: Wikipedia:Osteoporosis
has_obo_namespace: chebi_ontology
has_related_synonym: anti-osteopenia agent
has_related_synonym: anti-osteopenia agents
has_related_synonym: anti-osteopenia drug
has_related_synonym: anti-osteopenia drugs
has_related_synonym: anti-osteoporosis agent
has_related_synonym: anti-osteoporosis agents
has_related_synonym: anti-osteoporosis drug
has_related_synonym: anti-osteoporosis drugs
has_related_synonym: anti-osteoporotic
has_related_synonym: anti-osteoporotic agent
has_related_synonym: anti-osteoporotic agents
has_related_synonym: anti-osteoporotic drug
has_related_synonym: anti-osteoporotic drugs
has_related_synonym: anti-osteoporotics
has_related_synonym: antiosteoporotic
has_related_synonym: antiosteoporotics
has_related_synonym: bone density conservation agents
has_related_synonym: bone density conservation drug
has_related_synonym: bone density conservation drugs
id: CHEBI:50646
in subset: 3 STAR

matrix metalloproteinase inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: MMPI
has_related_synonym: matrix metalloproteinase inhibitors
id: CHEBI:50664
in subset: 3 STAR

antithyroid drug
type: Class
subclass of: hormone antagonist
textual definition: A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
imported from: chebi.owl
has cross-reference: Wikipedia:Antithyroid_agent
has_obo_namespace: chebi_ontology
has_related_synonym: antithyroid agent
has_related_synonym: antithyroid agents
has_related_synonym: antithyroid drugs
id: CHEBI:50671
in subset: 3 STAR

EC 1.5.1.3 (dihydrofolate reductase) inhibitor
type: Class
subclass of: antifolate
subclass of: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
imported from: chebi.owl
has cross-reference: Wikipedia:Dihydrofolate_reductase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: 7,8-dihydrofolate reductase inhibitor
has_related_synonym: 7,8-dihydrofolate reductase inhibitors
has_related_synonym: DHFR inhibitor
has_related_synonym: DHFR inhibitors
has_related_synonym: EC 1.5.1.3 (dihydrofolate reductase) inhibitors
has_related_synonym: EC 1.5.1.3 inhibitor
has_related_synonym: EC 1.5.1.3 inhibitors
has_related_synonym: NADPH-dihydrofolate reductase inhibitor
has_related_synonym: NADPH-dihydrofolate reductase inhibitors
has_related_synonym: dihydrofolate reductase (EC 1.5.1.3) inhibitor
has_related_synonym: dihydrofolate reductase (EC 1.5.1.3) inhibitors
has_related_synonym: dihydrofolate reductase inhibitor
has_related_synonym: dihydrofolate reductase inhibitors
has_related_synonym: dihydrofolic acid reductase inhibitor
has_related_synonym: dihydrofolic acid reductase inhibitors
has_related_synonym: dihydrofolic reductase inhibitor
has_related_synonym: dihydrofolic reductase inhibitors
has_related_synonym: folic acid reductase inhibitor
has_related_synonym: folic acid reductase inhibitors
has_related_synonym: folic reductase inhibitor
has_related_synonym: folic reductase inhibitors
has_related_synonym: tetrahydrofolate dehydrogenase inhibitor
has_related_synonym: tetrahydrofolate dehydrogenase inhibitors
id: CHEBI:50683
in subset: 3 STAR

cross-linking reagent
type: Class
subclass of: reagent
textual definition: A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cross-linking reagents
id: CHEBI:50684
in subset: 3 STAR

antitrichomonal drug
type: Class
subclass of: antiprotozoal drug
textual definition: A drug used to treat trichomonas infections.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antitrichomonal agent
id: CHEBI:50685
in subset: 3 STAR

reproductive control drug
type: Class
subclass of: drug
textual definition: A substance used either in the prevention or facilitation of pregnancy.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: reproductive control agent
has_related_synonym: reproductive control drugs
id: CHEBI:50689
in subset: 3 STAR

abortifacient
type: Class
subclass of: reproductive control drug
textual definition: A chemical substance that interrupts pregnancy after implantation.
imported from: chebi.owl
has cross-reference: Wikipedia:Abortifacient
has_obo_namespace: chebi_ontology
has_related_synonym: abortifacient agent
has_related_synonym: abortifacient agents
has_related_synonym: abortifacient drug
has_related_synonym: abortifacient drugs
has_related_synonym: abortifacients
id: CHEBI:50691
in subset: 3 STAR

EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of peptidoglycan glycosyltransferase (EC 2.4.1.129).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitors
has_related_synonym: EC 2.4.1.129 inhibitor
has_related_synonym: EC 2.4.1.129 inhibitors
has_related_synonym: PBP3 inhibitor
has_related_synonym: PG-II inhibitor
has_related_synonym: PG-II inhibitors
has_related_synonym: [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitor
has_related_synonym: [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitors
has_related_synonym: bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitor
has_related_synonym: bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitors
has_related_synonym: penicillin binding protein 1B inhibitor
has_related_synonym: penicillin binding protein 1B inhibitors
has_related_synonym: penicillin binding protein 3 inhibitor
has_related_synonym: penicillin binding protein 3 inhibitors
has_related_synonym: peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitor
has_related_synonym: peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitors
has_related_synonym: peptidoglycan glycosyltransferase inhibitor
has_related_synonym: peptidoglycan glycosyltransferase inhibitors
has_related_synonym: peptidoglycan transglycosylase inhibitor
has_related_synonym: peptidoglycan transglycosylase inhibitors
has_related_synonym: undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitor
has_related_synonym: undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitors
id: CHEBI:50696
in subset: 3 STAR

montelukast
type: Class
subclass of: molecular entity
imported from: chebi.owl
charge: 0
formula: C35H36ClNO3S
inchi: InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
inchikey: UCHDWCPVSPXUMX-TZIWLTJVSA-N
mass: 586.18398
monoisotopicmass: 585.21044
has_alternative_id: CHEBI:49756
has_alternative_id: CHEBI:6992
has cross-reference: Beilstein:7896575
has cross-reference: CAS:158966-92-8
has cross-reference: DrugBank:DB00471
has cross-reference: Drug_Central:1836
has cross-reference: KEGG:C07482
has cross-reference: KEGG:D08229
has cross-reference: PDBeChem:MTK
has cross-reference: Patent:EP1886997
has cross-reference: Wikipedia:Montelukast
alternative_term: MONTELUKAST
alternative_term: Montelukast
alternative_term: {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid
has_related_synonym: 1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid
has_related_synonym: montelukast
id: CHEBI:50730
in subset: 3 STAR

nutraceutical
type: Class
subclass of: drug
textual definition: A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Dietary Supplement
has_related_synonym: Food Supplementation
has_related_synonym: Nutritional supplement
id: CHEBI:50733
in subset: 3 STAR

estrogen receptor modulator
type: Class
subclass of: drug
textual definition: A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50739
in subset: 3 STAR

retinoic acid receptor alpha/beta agonist
type: Class
subclass of: retinoic acid receptor agonist
textual definition: Any retinoic acid receptor (RAR) agonist with specificity for RARalpha and RARbeta.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: RAR alpha/beta agonist
id: CHEBI:50741
in subset: 3 STAR

progestogen
type: Class
subclass of: sex hormone
textual definition: A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: gestagen
has_related_synonym: gestagens
has_related_synonym: progestagen
has_related_synonym: progestagens
has_related_synonym: progestogens
id: CHEBI:50745
in subset: 3 STAR

antipsoriatic
type: Class
subclass of: dermatologic drug
textual definition: A drug used to treat psoriasis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antipsoriatic agent
has_related_synonym: antipsoriatic drug
id: CHEBI:50748
in subset: 3 STAR

EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
type: Class
subclass of: topoisomerase inhibitor
textual definition: A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
imported from: chebi.owl
has_alternative_id: CHEBI:132229
has_alternative_id: CHEBI:50234
has_obo_namespace: chebi_ontology
has_related_synonym: DNA gyrase inhibitor
has_related_synonym: DNA gyrase inhibitors
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) inhibitor
has_related_synonym: DNA topoisomerase (ATP-hydrolysing) inhibitors
has_related_synonym: DNA topoisomerase II inhibitor
has_related_synonym: DNA topoisomerase II inhibitors
has_related_synonym: EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor
has_related_synonym: EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors
has_related_synonym: EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors
has_related_synonym: EC 5.99.1.3 inhibitor
has_related_synonym: EC 5.99.1.3 inhibitors
has_related_synonym: inhibitor of type II topoisomerase
has_related_synonym: inhibitors of type II topoisomerase
has_related_synonym: topoisomerase II inhibitor
has_related_synonym: topoisomerase II inhibitors
has_related_synonym: topoisomerase-II inhibitor
has_related_synonym: topoisomerase-II inhibitors
has_related_synonym: type II DNA topoisomerase inhibitor
has_related_synonym: type II DNA topoisomerase inhibitors
id: CHEBI:50750
in subset: 3 STAR

anti-estrogen
type: Class
subclass of: drug
textual definition: A drug which acts to reduce estrogenic activity in the body, either by reducing the amount of estrogen or by reducing the activity of whatever estrogen is present.
imported from: chebi.owl
has cross-reference: Wikipedia:Antiestrogen
has_obo_namespace: chebi_ontology
has_related_synonym: anti-estrogenic agent
has_related_synonym: anti-estrogenic drug
has_related_synonym: anti-oestrogen
has_related_synonym: anti-oestrogenic agent
has_related_synonym: anti-oestrogenic drug
has_related_synonym: antiestrogen
has_related_synonym: antiestrogenic agent
has_related_synonym: antiestrogenic drug
has_related_synonym: antioestrogen
has_related_synonym: antioestrogenic agent
has_related_synonym: antioestrogenic drug
id: CHEBI:50751
in subset: 3 STAR

appetite enhancer
type: Class
subclass of: appetite regulator
textual definition: A drug which increases appetite.
imported from: chebi.owl
has cross-reference: Wikipedia:Appetite_stimulants
has_obo_namespace: chebi_ontology
has_related_synonym: appetite enhancing drug
has_related_synonym: appetite stimulant
has_related_synonym: orexigenic
id: CHEBI:50779
in subset: 3 STAR

appetite regulator
type: Class
subclass of: drug
textual definition: An agent which regulates the physiologic mechanisms that control the appetite and food intake.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: appetite regulators
id: CHEBI:50780
in subset: 3 STAR

EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor
type: Class
subclass of: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of of 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)), EC 1.3.1.22, the enzyme which converts testosterone (CHEBI:17347) into the more potent androgen 5alpha-dihydrotestosterone.
imported from: chebi.owl
has cross-reference: Wikipedia:5-alpha-reductase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) (EC 1.3.1.22) inhibitor
has_related_synonym: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) (EC 1.3.1.22) inhibitors
has_related_synonym: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) inhibitor
has_related_synonym: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) inhibitors
has_related_synonym: 3-oxo-5alpha-steroid 4-dehydrogenase inhibitor
has_related_synonym: 3-oxo-5alpha-steroid 4-dehydrogenase inhibitors
has_related_synonym: 3-oxo-5alpha-steroid:NADP+ Delta(4)-oxidoreductase inhibitor
has_related_synonym: 3-oxo-5alpha-steroid:NADP+ Delta(4)-oxidoreductase inhibitors
has_related_synonym: 3-oxosteroid 5alpha-reductase inhibitor
has_related_synonym: 3-oxosteroid Delta4-dehydrogenase inhibitor
has_related_synonym: 4-ene-3-oxosteroid 5alpha-reductase inhibitor
has_related_synonym: 4-ene-5alpha-reductase inhibitor
has_related_synonym: 5alpha-oxidoreductase inhibitor
has_related_synonym: 5alpha-oxidoreductase inhibitors
has_related_synonym: 5alpha-reductase inhibitor
has_related_synonym: 5alpha-reductase inhibitors
has_related_synonym: Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitor
has_related_synonym: Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitors
has_related_synonym: EC 1.3.1.22 (3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))) inhibitor
has_related_synonym: EC 1.3.1.22 (3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))) inhibitors
has_related_synonym: EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitors
has_related_synonym: EC 1.3.1.22 inhibitor
has_related_synonym: EC 1.3.1.22 inhibitors
has_related_synonym: cholest-4-en-3-one 5alpha-reductase inhibitor
has_related_synonym: cholestenone 5alpha-reductase inhibitor
has_related_synonym: cholestenone 5alpha-reductase inhibitors
has_related_synonym: reduced nicotinamide adenine dinucleotide phosphate:Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitor
has_related_synonym: reduced nicotinamide adenine dinucleotide phosphate:Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitors
has_related_synonym: steroid 5alpha-hydrogenase inhibitor
has_related_synonym: steroid 5alpha-hydrogenase inhibitors
has_related_synonym: steroid 5alpha-reductase inhibitor
has_related_synonym: steroid 5alpha-reductase inhibitors
has_related_synonym: testosterone 5alpha-reductase inhibitor
has_related_synonym: testosterone 5alpha-reductase inhibitors
has_related_synonym: testosterone Delta(4)-5alpha-reductase inhibitor
has_related_synonym: testosterone Delta(4)-5alpha-reductase inhibitors
has_related_synonym: testosterone Delta(4)-hydrogenase inhibitor
has_related_synonym: testosterone Delta(4)-hydrogenase inhibitors
id: CHEBI:50781
in subset: 3 STAR

EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor which interferes with the action of 3beta-hydroxysteroid dehydrogenase (EC 1.1.1.210), a group of steroidogenic enzymes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 3beta (or 20alpha)-hydroxysteroid dehydrogenase inhibitor
has_related_synonym: 3beta (or 20alpha)-hydroxysteroid dehydrogenase inhibitors
has_related_synonym: 3beta(or 20alpha)-hydroxysteroid dehydrogenase (EC 1.1.1.210) inhibitor
has_related_synonym: 3beta(or 20alpha)-hydroxysteroid dehydrogenase (EC 1.1.1.210) inhibitors
has_related_synonym: 3beta(or 20alpha)-hydroxysteroid dehydrogenase inhibitor
has_related_synonym: 3beta(or 20alpha)-hydroxysteroid dehydrogenase inhibitors
has_related_synonym: 3beta(or 20alpha)-hydroxysteroid:NADP(+) oxidoreductase inhibitor
has_related_synonym: 3beta(or 20alpha)-hydroxysteroid:NADP(+) oxidoreductase inhibitors
has_related_synonym: 3beta,20alpha-hydroxysteroid oxidoreductase inhibitor
has_related_synonym: 3beta,20alpha-hydroxysteroid oxidoreductase inhibitors
has_related_synonym: 3beta-HSD
has_related_synonym: 3beta-hydroxysteroid dehydrogenase
has_related_synonym: 3beta-hydroxysteroid dehydrogenase inhibitor
has_related_synonym: EC 1.1.1.210 (3beta(or 20alpha)-hydroxysteroid dehydrogenase) inhibitor
has_related_synonym: EC 1.1.1.210 (3beta(or 20alpha)-hydroxysteroid dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitors
has_related_synonym: EC 1.1.1.210 inhibitor
has_related_synonym: EC 1.1.1.210 inhibitors
has_related_synonym: dehydrogenase, 3beta,20alpha-hydroxy steroid inhibitor
has_related_synonym: dehydrogenase, 3beta,20alpha-hydroxy steroid inhibitors
has_related_synonym: progesterone reductase inhibitor
has_related_synonym: progesterone reductase inhibitors
id: CHEBI:50788
in subset: 3 STAR

EC 1.14.14.14 (aromatase) inhibitor
type: Class
subclass of: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
textual definition: An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor which interferes with the action of aromatase (EC 1.14.14.14) and so reduces production of estrogenic steroid hormones.
imported from: chebi.owl
has cross-reference: Wikipedia:Aromatase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.14.14 (aromatase) inhibitors
has_related_synonym: EC 1.14.14.14 inhibitor
has_related_synonym: EC 1.14.14.14 inhibitors
has_related_synonym: aromatase (EC 1.14.14.14) inhibitor
has_related_synonym: aromatase (EC 1.14.14.14) inhibitors
has_related_synonym: aromatase inhibitor
has_related_synonym: aromatase inhibitors
has_related_synonym: estrogen synthase inhibitor
has_related_synonym: estrogen synthase inhibitors
has_related_synonym: estrogen synthetase inhibitor
has_related_synonym: estrogen synthetase inhibitors
has_related_synonym: oestrogen synthase inhibitor
has_related_synonym: oestrogen synthase inhibitors
has_related_synonym: oestrogen synthetase inhibitor
has_related_synonym: oestrogen synthetase inhibitors
id: CHEBI:50790
in subset: 3 STAR

estrogen receptor antagonist
type: Class
subclass of: drug
subclass of: antagonist
textual definition: An antagonist at the estrogen receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: estrogen receptor antagonists
id: CHEBI:50792
in subset: 3 STAR

antiparathyroid drug
type: Class
subclass of: hormone antagonist
textual definition: A drug used to treat hyperparathyroidism by reducing the excessive production of parathyroid hormones.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antiparathyroid agent
has_related_synonym: antiparathyroid agents
has_related_synonym: antiparathyroid drugs
id: CHEBI:50827
in subset: 3 STAR

estrogen antagonist
type: Class
subclass of: hormone antagonist
textual definition: A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: oestrogen antagonist
id: CHEBI:50837
in subset: 3 STAR

antimineralocorticoid
type: Class
subclass of: hormone antagonist
textual definition: A compound which inhibits or antagonizes the biosynthesis or actions of mineralocorticoids, a class of steroid hormones characterised by their similarity to aldosterone and their influence on salt and water balance.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50843
in subset: 3 STAR

aldosterone antagonist
type: Class
subclass of: antimineralocorticoid
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50844
in subset: 1 STAR

immunomodulator
type: Class
subclass of: drug
subclass of: biological role
textual definition: Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
imported from: chebi.owl
has cross-reference: Wikipedia:Immunotherapy
has_obo_namespace: chebi_ontology
has_related_synonym: Biomodulator
has_related_synonym: Immune factor
has_related_synonym: Immunologic factor
has_related_synonym: Immunological factor
has_related_synonym: immunomodulators
id: CHEBI:50846
in subset: 3 STAR

immunological adjuvant
type: Class
subclass of: immunomodulator
subclass of: adjuvant
textual definition: A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
imported from: chebi.owl
has cross-reference: Wikipedia:Immunologic_adjuvant
has_obo_namespace: chebi_ontology
has_related_synonym: Immunoactivator
has_related_synonym: Immunoadjuvant
has_related_synonym: Immunologic adjuvant
has_related_synonym: Immunopotentiator
has_related_synonym: Immunostimulant
id: CHEBI:50847
in subset: 3 STAR

antiatherogenic agent
type: Class
subclass of: cardiovascular drug
textual definition: A cardiovascular drug that prevents atherogenesis, the accumulation of lipid-containing plaques on the innermost layers of the arteries. Compare with antiatherosclerotic agent.
imported from: chebi.owl
has cross-reference: PMID:14592471
has cross-reference: PMID:16366593
has cross-reference: PMID:17990280
has cross-reference: PMID:20222342
has cross-reference: PMID:21074432
has cross-reference: PMID:21172387
has cross-reference: PMID:21649483
has cross-reference: PMID:3288054
has cross-reference: PMID:9796331
alternative_term: antiatherogenic agent
has_obo_namespace: chebi_ontology
has_related_synonym: anti-atherogenic agent
has_related_synonym: anti-atherogenic agents
has_related_synonym: anti-atherogenic drug
has_related_synonym: anti-atherogenic drugs
has_related_synonym: antiatherogenic agents
has_related_synonym: antiatherogenic drug
has_related_synonym: antiatherogenic drugs
id: CHEBI:50855
in subset: 3 STAR

anti-allergic agent
type: Class
subclass of: drug
textual definition: A drug used to treat allergic reactions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-allergic agents
has_related_synonym: anti-allergic drug
has_related_synonym: anti-allergic drugs
id: CHEBI:50857
in subset: 3 STAR

insulin-sensitizing drug
type: Class
subclass of: hypoglycemic agent
subclass of: agonist
subclass of: PPAR modulator
textual definition: An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: PPAR-gamma agonist
has_related_synonym: PPAR-gamma agonists
has_related_synonym: PPARgamma agonist
has_related_synonym: PPARgamma agonists
has_related_synonym: glitazonas
has_related_synonym: glitazone drug
has_related_synonym: glitazones
has_related_synonym: insulin sensitisers
has_related_synonym: insulin sensitizers
has_related_synonym: insulin-sensitising drug
has_related_synonym: insulin-sensitizing agent
has_related_synonym: peroxisome proliferator-activated receptor gamma agonist
has_related_synonym: peroxisome proliferator-activated receptor gamma agonists
has_related_synonym: proliferator activated receptor gamma agonist
has_related_synonym: proliferator activated receptor gamma agonists
has_related_synonym: thiazolidinediones
has_related_synonym: tiazolidinedionas
id: CHEBI:50864
in subset: 3 STAR

genotoxin
type: Class
subclass of: aetiopathogenetic role
textual definition: A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
imported from: chebi.owl
has cross-reference: Wikipedia:Genotoxicity
has_obo_namespace: chebi_ontology
has_related_synonym: genotoxic agent
has_related_synonym: genotoxic agents
has_related_synonym: genotoxins
id: CHEBI:50902
in subset: 3 STAR

carcinogenic agent
type: Class
subclass of: aetiopathogenetic role
textual definition: A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: agente carcinogeno
has_related_synonym: cancerigene
has_related_synonym: cancerogene
has_related_synonym: carcinogen
has_related_synonym: carcinogene
has_related_synonym: carcinogenic agents
has_related_synonym: carcinogeno
has_related_synonym: carcinogens
id: CHEBI:50903
in subset: 3 STAR

allergen
type: Class
subclass of: aetiopathogenetic role
textual definition: A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
imported from: chebi.owl
has cross-reference: Wikipedia:Allergen
has_obo_namespace: chebi_ontology
has_related_synonym: alergeno
has_related_synonym: allergene
has_related_synonym: allergenic agent
id: CHEBI:50904
in subset: 3 STAR

teratogenic agent
type: Class
subclass of: aetiopathogenetic role
textual definition: A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: agent teratogene
has_related_synonym: teratogen
has_related_synonym: teratogeno
id: CHEBI:50905
in subset: 3 STAR

deaminating agent
type: Class
subclass of: chemical role
textual definition: A deaminating agent is a role played by a chemical agent which exhibits the capability of causing the loss of an amine functional group on another molecular entity (e.g. DNA or protein).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50907
in subset: 3 STAR

hepatotoxic agent
type: Class
subclass of: aetiopathogenetic role
textual definition: A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: agente hepatotoxico
has_related_synonym: hepatotoxic agents
has_related_synonym: hepatotoxicant
has_related_synonym: hepatotoxicants
has_related_synonym: hepatotoxin
has_related_synonym: hepatotoxins
has_related_synonym: hepatoxic agent
has_related_synonym: hepatoxicant
id: CHEBI:50908
in subset: 3 STAR

nephrotoxic agent
type: Class
subclass of: aetiopathogenetic role
textual definition: A role played by any chemical compound (natural or synthetic) exhibiting itself through the ability to induce damage to the kidneys.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: agente nefrotoxico
has_related_synonym: nephrotoxic agents
has_related_synonym: nephrotoxicant
id: CHEBI:50909
in subset: 3 STAR

neurotoxin
type: Class
subclass of: aetiopathogenetic role
subclass of: poison
textual definition: A poison that interferes with the functions of the nervous system.
imported from: chebi.owl
has_alternative_id: CHEBI:50911
has cross-reference: Wikipedia:Neurotoxin
has_obo_namespace: chebi_ontology
has_related_synonym: agente neurotoxico
has_related_synonym: nerve poison
has_related_synonym: nerve poisons
has_related_synonym: neurotoxic agent
has_related_synonym: neurotoxic agents
has_related_synonym: neurotoxicant
has_related_synonym: neurotoxins
id: CHEBI:50910
in subset: 3 STAR

cardiotoxic agent
type: Class
subclass of: aetiopathogenetic role
textual definition: A role played by a chemical compound exhibiting itself through the ability to induce damage to the heart and cardiomyocytes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cardiotoxicant
id: CHEBI:50912
in subset: 3 STAR

fixative
type: Class
subclass of: biological role
textual definition: Any compound used for the purpose of preserving biological tissues from decay in such a way as to allow for the preparation of thin, stained sections for subsequent histological study.
imported from: chebi.owl
has cross-reference: Wikipedia:Fixation_(histology)
has_obo_namespace: chebi_ontology
has_related_synonym: fixating agent
has_related_synonym: fixating agents
has_related_synonym: fixation agent
id: CHEBI:50913
in subset: 3 STAR

EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
type: Class
subclass of: lipid kinase inhibitor
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 1-phosphatidylinositol 3-kinase inhibitor
has_related_synonym: 1-phosphatidylinositol 3-kinase inhibitors
has_related_synonym: ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase inhibitor
has_related_synonym: ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase inhibitors
has_related_synonym: EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitors
has_related_synonym: EC 2.7.1.137 inhibitor
has_related_synonym: EC 2.7.1.137 inhibitors
has_related_synonym: PI(3)K inhibitor
has_related_synonym: PI(3)K inhibitors
has_related_synonym: PI-3 kinase inhibitor
has_related_synonym: PI-3 kinase inhibitors
has_related_synonym: PI3-kinase inhibitor
has_related_synonym: PI3-kinase inhibitors
has_related_synonym: PI3K inhibitor
has_related_synonym: PI3K inhibitors
has_related_synonym: PtdIns-3-kinase inhibitor
has_related_synonym: PtdIns-3-kinase inhibitors
has_related_synonym: Vps34p inhibitor
has_related_synonym: Vps34p inhibitors
has_related_synonym: phosphatidylinositol 3-kinase (EC 2.7.1.137) inhibitor
has_related_synonym: phosphatidylinositol 3-kinase (EC 2.7.1.137) inhibitors
has_related_synonym: phosphatidylinositol 3-kinase inhibitor
has_related_synonym: phosphatidylinositol 3-kinase inhibitors
has_related_synonym: phosphatidylinositol-3-OH kinase inhibitor
has_related_synonym: phosphatidylinositol-3-OH kinase inhibitors
has_related_synonym: phosphoinositide 3-kinase inhibitor
has_related_synonym: phosphoinositide 3-kinase inhibitors
has_related_synonym: type I phosphatidylinositol kinase inhibitor
has_related_synonym: type I phosphatidylinositol kinase inhibitors
has_related_synonym: type III phosphoinositide 3-kinase inhibitor
has_related_synonym: type III phosphoinositide 3-kinase inhibitors
id: CHEBI:50914
in subset: 3 STAR

lipid kinase inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of lipid kinases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: lipid kinase inhibitors
id: CHEBI:50916
in subset: 3 STAR

antiemetic
type: Class
subclass of: drug
textual definition: A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Antiemetic
has_obo_namespace: chebi_ontology
has_related_synonym: anti-emetic
has_related_synonym: anti-emetics
has_related_synonym: antiemetico
has_related_synonym: antiemetics
id: CHEBI:50919
in subset: 3 STAR

EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
imported from: chebi.owl
has_alternative_id: CHEBI:75764
has_obo_namespace: chebi_ontology
has_related_synonym: A-kinase inhibitor
has_related_synonym: A-kinase inhibitors
has_related_synonym: AP50 kinase inhibitor
has_related_synonym: AP50 kinase inhibitors
has_related_synonym: ATP-protein transphosphorylase inhibitor
has_related_synonym: ATP-protein transphosphorylase inhibitors
has_related_synonym: ATP:protein phosphotransferase (non-specific) inhibitor
has_related_synonym: ATP:protein phosphotransferase (non-specific) inhibitors
has_related_synonym: BR serine/threonine-protein kinase 2 inhibitor
has_related_synonym: BR serine/threonine-protein kinase 2 inhibitors
has_related_synonym: CK-2 inhibitor
has_related_synonym: CK-2 inhibitors
has_related_synonym: CKI inhibitor
has_related_synonym: CKI inhibitors
has_related_synonym: CKII inhibitor
has_related_synonym: CKII inhibitors
has_related_synonym: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors
has_related_synonym: EC 2.7.11.1 inhibitor
has_related_synonym: EC 2.7.11.1 inhibitors
has_related_synonym: HIPK2 inhibitor
has_related_synonym: HIPK2 inhibitors
has_related_synonym: Hpr kinase inhibitor
has_related_synonym: Hpr kinase inhibitors
has_related_synonym: M phase-specific cdc2 kinase inhibitor
has_related_synonym: M phase-specific cdc2 kinase inhibitors
has_related_synonym: MKNK2 inhibitor
has_related_synonym: MKNK2 inhibitors
has_related_synonym: PAK-1 inhibitor
has_related_synonym: PAK-1 inhibitors
has_related_synonym: PAK1 inhibitor
has_related_synonym: PAK1 inhibitors
has_related_synonym: PKA inhibitor
has_related_synonym: PKA inhibitors
has_related_synonym: Prp4 protein kinase inhibitor
has_related_synonym: Prp4 protein kinase inhibitors
has_related_synonym: Raf kinase inhibitor
has_related_synonym: Raf kinase inhibitors
has_related_synonym: Raf-1 inhibitor
has_related_synonym: Raf-1 inhibitors
has_related_synonym: STK32 inhibitor
has_related_synonym: STK32 inhibitors
has_related_synonym: T-antigen kinase inhibitor
has_related_synonym: T-antigen kinase inhibitors
has_related_synonym: WEE1Hu inhibitor
has_related_synonym: WEE1Hu inhibitors
has_related_synonym: Wee 1-like kinase inhibitor
has_related_synonym: Wee 1-like kinase inhibitors
has_related_synonym: Wee-kinase inhibitor
has_related_synonym: Wee-kinase inhibitors
has_related_synonym: betaIIPKC inhibitor
has_related_synonym: betaIIPKC inhibitors
has_related_synonym: cAMP-dependent protein kinase A inhibitor
has_related_synonym: cAMP-dependent protein kinase A inhibitors
has_related_synonym: cAMP-dependent protein kinase inhibitor
has_related_synonym: cAMP-dependent protein kinase inhibitors
has_related_synonym: cGMP-dependent protein kinase inhibitor
has_related_synonym: cGMP-dependent protein kinase inhibitors
has_related_synonym: calcium-dependent protein kinase C inhibitor
has_related_synonym: calcium-dependent protein kinase C inhibitors
has_related_synonym: calcium/phospholipid-dependent protein kinase inhibitor
has_related_synonym: calcium/phospholipid-dependent protein kinase inhibitors
has_related_synonym: casein kinase (phosphorylating) inhibitor
has_related_synonym: casein kinase (phosphorylating) inhibitors
has_related_synonym: casein kinase 2 inhibitor
has_related_synonym: casein kinase 2 inhibitors
has_related_synonym: casein kinase I inhibitor
has_related_synonym: casein kinase I inhibitors
has_related_synonym: casein kinase II inhibitor
has_related_synonym: casein kinase II inhibitors
has_related_synonym: casein kinase inhibitor
has_related_synonym: casein kinase inhibitors
has_related_synonym: cyclic AMP-dependent protein kinase A inhibitor
has_related_synonym: cyclic AMP-dependent protein kinase A inhibitors
has_related_synonym: cyclic AMP-dependent protein kinase inhibitor

angiogenesis modulating agent
type: Class
subclass of: drug
textual definition: An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:50926
in subset: 3 STAR

serotonin uptake inhibitor
type: Class
subclass of: serotonergic drug
textual definition: A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
imported from: chebi.owl
has cross-reference: Wikipedia:Selective_serotonin_reuptake_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: SSRI
has_related_synonym: serotonin reuptake inhibitor
id: CHEBI:50949
in subset: 3 STAR

dopamine uptake inhibitor
type: Class
subclass of: dopaminergic agent
textual definition: A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
imported from: chebi.owl
has cross-reference: Wikipedia:Dopamine_uptake_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: DARI
has_related_synonym: DRI
has_related_synonym: dopamine reuptake inhibitor
has_related_synonym: dopamine reuptake inhibitors
has_related_synonym: dopamine uptake inhibitors
id: CHEBI:51039
in subset: 3 STAR

hormone agonist
type: Class
subclass of: agonist
subclass of: hormone receptor modulator
textual definition: A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51060
in subset: 3 STAR

hormone receptor modulator
type: Class
subclass of: drug
subclass of: receptor modulator
textual definition: A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hormone receptor modulators
id: CHEBI:51061
in subset: 3 STAR

dopamine agonist
type: Class
subclass of: dopaminergic agent
textual definition: A drug that binds to and activates dopamine receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Agonista dopaminergico
has_related_synonym: Dopamine receptor agonist
has_related_synonym: Dopaminergic agonist
id: CHEBI:51065
in subset: 3 STAR

miotic
type: Class
subclass of: neurotransmitter agent
textual definition: An agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Miotico
has_related_synonym: miotics
id: CHEBI:51068
in subset: 3 STAR

antifouling biocide
type: Class
subclass of: pesticide
textual definition: A compound that inhibits the growth of marine organisms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Antifoulant
has_related_synonym: Antifouling agent
has_related_synonym: Marine pesticide
id: CHEBI:51076
in subset: 3 STAR

chemical role
type: Class
subclass of: BAO_0002929
textual definition: A role played by the molecular entity or part thereof within a chemical context.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51086
in subset: 3 STAR

protecting group
type: Class
subclass of: application
textual definition: A group that is introduced into a molecule by chemical modification of a functional group in order to obtain chemoselectivity in a subsequent chemical reaction.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Schutzgruppe
has_related_synonym: Schutzgruppen
has_related_synonym: groupe protecteur
has_related_synonym: protective group
id: CHEBI:51087
in subset: 3 STAR

fluorescent dye
type: Class
subclass of: dye
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fluorescent dyes
id: CHEBI:51121
in subset: 3 STAR

Wittig reagent
type: Class
subclass of: reagent
textual definition: A role played by a phosphonium ylide in a Wittig reaction.
imported from: chebi.owl
alternative_term: Wittig reagents
has_obo_namespace: chebi_ontology
has_related_synonym: reactif de Wittig
has_related_synonym: reactivo de Wittig
has_related_synonym: reactivos de Wittig
id: CHEBI:51166
in subset: 3 STAR

antitussive
type: Class
subclass of: drug
textual definition: An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-tussive
has_related_synonym: cough suppressant
has_related_synonym: cough suppressants
id: CHEBI:51177
in subset: 3 STAR

fluorochrome
type: Class
subclass of: fluorescent dye
textual definition: A fluorescent dye used to stain biological specimens.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fluorochromes
id: CHEBI:51217
in subset: 3 STAR

Grignard reagent
type: Class
subclass of: reagent
textual definition: A role played by an organomagnesium halide in a Grignard reaction.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Grignards Reagens
id: CHEBI:51237
in subset: 3 STAR

gelator
type: Class
subclass of: reagent
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51266
in subset: 1 STAR

swelling agent
type: Class
subclass of: reagent
textual definition: A role played by a compound in a fluid state in swelling a gel, network, or solid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51267
in subset: 3 STAR

drying control chemical additive
type: Class
subclass of: solvent
textual definition: A role played by a compound that facilitates the rapid drying of gels without their cracking.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51268
in subset: 3 STAR

muscle relaxant
type: Class
subclass of: neuromuscular agent
textual definition: A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: muscle relaxants
id: CHEBI:51371
in subset: 3 STAR

neuromuscular agent
type: Class
subclass of: drug
textual definition: A drug used for its actions on skeletal muscle.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51372
in subset: 3 STAR

GABA agonist
type: Class
subclass of: GABA agent
textual definition: A drug that binds to and activates gamma-aminobutyric acid receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GABA agonists
has_related_synonym: GABA receptor agonist
has_related_synonym: GABA receptor agonists
has_related_synonym: gamma-aminobutyric acid receptor agonist
has_related_synonym: gamma-aminobutyric acid receptor agonists
id: CHEBI:51373
in subset: 3 STAR

GABA agent
type: Class
subclass of: neurotransmitter agent
textual definition: A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51374
in subset: 3 STAR

endothelin receptor antagonist
type: Class
subclass of: hormone antagonist
textual definition: A hormone antagonist that blocks endothelin receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ERA
id: CHEBI:51451
in subset: 3 STAR

endothelin A receptor antagonist
type: Class
subclass of: endothelin receptor antagonist
textual definition: A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51452
in subset: 3 STAR

partial prostacyclin agonist
type: Class
subclass of: vasodilator agent
subclass of: platelet aggregation inhibitor
textual definition: A compound which binds and activates the prostacyclin receptor IP1, but has only partial efficacy at the receptor relative to a full agonist.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51577
in subset: 3 STAR

biochemical role
type: Class
subclass of: biological role
textual definition: A biological role played by the molecular entity or part thereof within a biochemical context.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52206
in subset: 3 STAR

biophysical role
type: Class
subclass of: biological role
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52208
in subset: 1 STAR

aetiopathogenetic role
type: Class
subclass of: biological role
textual definition: A role played by the molecular entity or part thereof which causes the development of a pathological process.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: etiopathogenetic agent
has_related_synonym: etiopathogenetic role
id: CHEBI:52209
in subset: 3 STAR

pharmacological role
type: Class
subclass of: biological role
textual definition: A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52210
in subset: 3 STAR

physiological role
type: Class
subclass of: biological role
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52211
in subset: 1 STAR

ligand
type: Class
subclass of: chemical role
textual definition: Any molecule or ion capable of binding to a central metal atom to form coordination complexes.
imported from: chebi.owl
has cross-reference: Wikipedia:Ligand
has_obo_namespace: chebi_ontology
has_related_synonym: ligands
id: CHEBI:52214
in subset: 3 STAR

photochemical role
type: Class
subclass of: chemical role
textual definition: A chemical role played by the molecular entity or part thereof in a photochemical process.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: photochemical roles
id: CHEBI:52215
in subset: 3 STAR

photobiochemical role
type: Class
subclass of: biochemical role
subclass of: photochemical role
textual definition: A role played by a molecular entity or part thereof in a photobiochemical process.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52216
in subset: 3 STAR

pharmaceutical
type: Class
subclass of: application
textual definition: Any substance introduced into a living organism with therapeutic or diagnostic purpose.
imported from: chebi.owl
has_alternative_id: CHEBI:33293
has_alternative_id: CHEBI:33294
has_obo_namespace: chebi_ontology
has_related_synonym: farmaco
has_related_synonym: medicament
has_related_synonym: pharmaceuticals
id: CHEBI:52217
in subset: 3 STAR

squaraine dye
type: Class
subclass of: fluorescent dye
textual definition: An organic dye characterized by an aromatic four-membered ring system derived from squaric acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52271
in subset: 3 STAR

mitogen
type: Class
subclass of: biological role
textual definition: A chemical substance that encourages a cell to commence cell division, triggering mitosis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mitogens
id: CHEBI:52290
in subset: 3 STAR

sterol methyltransferase inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of sterol methyltransferase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52303
in subset: 3 STAR

EC 3.2.1.* (glycosidase) inhibitor
type: Class
subclass of: EC 3.2.* (glycosylase) inhibitor
textual definition: An EC 3.2.* (glycosylase) inhibitor that interferes with the action of any glycosidase (i.e. enzymes hydrolysing O- and S-glycosyl compounds, EC 3.2.1.*).
imported from: chebi.owl
has_alternative_id: CHEBI:76776
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.* (glycosidase) inhibitors
has_related_synonym: EC 3.2.1.* inhibitor
has_related_synonym: EC 3.2.1.* inhibitors
has_related_synonym: glycosidase (EC 3.2.1.*) inhibitor
has_related_synonym: glycosidase (EC 3.2.1.*) inhibitors
has_related_synonym: glycosidase inhibitor
has_related_synonym: glycosidase inhibitors
has_related_synonym: glycoside hydrolase inhibitors
id: CHEBI:52424
in subset: 3 STAR

EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
type: Class
subclass of: antiviral drug
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.18 (exo-alpha-sialidase) inhibitors
has_related_synonym: EC 3.2.1.18 inhibitor
has_related_synonym: EC 3.2.1.18 inhibitors
has_related_synonym: N-acylneuraminate glycohydrolase inhibitor
has_related_synonym: N-acylneuraminate glycohydrolase inhibitors
has_related_synonym: acetylneuraminidase inhibitor
has_related_synonym: acetylneuraminidase inhibitors
has_related_synonym: acetylneuraminyl hydrolase inhibitor
has_related_synonym: acetylneuraminyl hydrolase inhibitors
has_related_synonym: alpha-neuraminidase inhibitor
has_related_synonym: alpha-neuraminidase inhibitors
has_related_synonym: exo-alpha-sialidase (EC 3.2.1.18) inhibitor
has_related_synonym: exo-alpha-sialidase (EC 3.2.1.18) inhibitors
has_related_synonym: exo-alpha-sialidase inhibitor
has_related_synonym: exo-alpha-sialidase inhibitors
has_related_synonym: neuraminidase inhibitor
has_related_synonym: neuraminidase inhibitors
has_related_synonym: sialidase inhibitor
has_related_synonym: sialidase inhibitors
id: CHEBI:52425
in subset: 3 STAR

EC 3.1.26.13 (retroviral ribonuclease H) inhibitor
type: Class
subclass of: anti-HIV-1 agent
subclass of: EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor
textual definition: An inhibitor of ribonuclease H (EC 3.1.26.13), an enzyme required for specific hydrolysis of the RNA strand of an RNA/DNA hybrid.
imported from: chebi.owl
has cross-reference: Wikipedia:Retroviral_ribonuclease_H
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.26.13 (retroviral ribonuclease H) inhibitors
has_related_synonym: EC 3.1.26.13 inhibitor
has_related_synonym: EC 3.1.26.13 inhibitors
has_related_synonym: HIV RNase H inhibitor
has_related_synonym: HIV RNase H inhibitors
has_related_synonym: HIV-1 RNase H inhibitor
has_related_synonym: HIV-1 RNase H inhibitors
has_related_synonym: HIV-1 ribonuclease H inhibitor
has_related_synonym: HIV-1 ribonuclease H inhibitors
has_related_synonym: RT/RNase H inhibitor
has_related_synonym: RT/RNase H inhibitors
has_related_synonym: retroviral reverse transcriptase RNaseH inhibitor
has_related_synonym: retroviral reverse transcriptase RNaseH inhibitors
has_related_synonym: retroviral ribonuclease H (EC 3.1.26.13) inhibitor
has_related_synonym: retroviral ribonuclease H (EC 3.1.26.13) inhibitors
has_related_synonym: retroviral ribonuclease H inhibitor
id: CHEBI:52629
in subset: 3 STAR

proteasome inhibitor
type: Class
subclass of: drug
textual definition: A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: proteasome inhibitors
id: CHEBI:52726
in subset: 3 STAR

phosphate protecting group
type: Class
subclass of: protecting group
textual definition: A group that serves to protect a phosphate group in the context of a synthesis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phosphate protecting groups
id: CHEBI:52941
in subset: 3 STAR

carboxylic acid protecting group
type: Class
subclass of: protecting group
textual definition: A group that serves to protect a carboxylic acid function in the context of a synthesis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carboxylic acid protecting groups
id: CHEBI:52943
in subset: 3 STAR

epitope
type: Class
subclass of: biological role
textual definition: The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antigenic determinant
has_related_synonym: epitope function
has_related_synonym: epitope role
id: CHEBI:53000
in subset: 3 STAR

adenosine A2A receptor antagonist
type: Class
subclass of: adenosine receptor antagonist
textual definition: An antagonist at the A2A receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_A2A_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine A2A receptor antagonists
id: CHEBI:53121
in subset: 3 STAR

P2Y2 receptor agonist
type: Class
subclass of: agonist
textual definition: A compound that exhibits agonist activity at the P2Y2 receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: P2Y2 receptor agonists
id: CHEBI:53142
in subset: 3 STAR

tissue adhesive
type: Class
subclass of: biological role
textual definition: A substance used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: tissue adhesives
id: CHEBI:53337
in subset: 3 STAR

GHB receptor agonist
type: Class
subclass of: neurotransmitter agent
textual definition: A drug that binds to and activates gamma-hydroxybutyric acid receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GHB receptor agonists
id: CHEBI:53353
in subset: 3 STAR

chain carrier
type: Class
subclass of: chemical role
textual definition: The role played by a molecular entity, such as an atom or free radical, which is involved in chain-propagating reactions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: chain carriers
id: CHEBI:53431
in subset: 3 STAR

topoisomerase IV inhibitor
type: Class
subclass of: topoisomerase inhibitor
textual definition: A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: topoisomerase IV inhibitors
id: CHEBI:53559
in subset: 3 STAR

EC 1.4.3.22 (diamine oxidase) inhibitor
type: Class
subclass of: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor
textual definition: An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of diamine oxidase (EC 1.4.3.22).
imported from: chebi.owl
has cross-reference: Wikipedia:Diamine_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.3.22 (diamine oxidase) inhibitors
has_related_synonym: EC 1.4.3.22 inhibitor
has_related_synonym: EC 1.4.3.22 inhibitors
has_related_synonym: diamine oxidase (EC 1.4.3.22) inhibitor
has_related_synonym: diamine oxidase (EC 1.4.3.22) inhibitors
has_related_synonym: diamine oxidase inhibitor
has_related_synonym: diamine oxidase inhibitors
has_related_synonym: histaminase inhibitor
has_related_synonym: histaminase inhibitors
has_related_synonym: histamine:oxygen oxidoreductase (deaminating) inhibitor
has_related_synonym: histamine:oxygen oxidoreductase (deaminating) inhibitors
id: CHEBI:53659
in subset: 3 STAR

EC 1.1.1.205 (IMP dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.1.205 (IMP dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.205 inhibitor
has_related_synonym: EC 1.1.1.205 inhibitors
has_related_synonym: IMP dehydrogenase (EC 1.1.1.205) inhibitor
has_related_synonym: IMP dehydrogenase (EC 1.1.1.205) inhibitors
has_related_synonym: IMP dehydrogenase inhibitor
has_related_synonym: IMP dehydrogenase inhibitors
has_related_synonym: IMP oxidoreductase inhibitor
has_related_synonym: IMP oxidoreductase inhibitors
has_related_synonym: IMP:NAD(+) oxidoreductase inhibitor
has_related_synonym: IMP:NAD(+) oxidoreductase inhibitors
has_related_synonym: inosinate dehydrogenase inhibitor
has_related_synonym: inosinate dehydrogenase inhibitors
has_related_synonym: inosine 5'-monophosphate dehydrogenase inhibitors
has_related_synonym: inosine monophosphate dehydrogenase inhibitor
has_related_synonym: inosine monophosphate dehydrogenase inhibitors
has_related_synonym: inosine monophosphate oxidoreductase inhibitor
has_related_synonym: inosine monophosphate oxidoreductase inhibitors
has_related_synonym: inosinic acid dehydrogenase inhibitor
has_related_synonym: inosinic acid dehydrogenase inhibitors
id: CHEBI:53746
in subset: 3 STAR

HIV-1 reverse transcriptase inhibitor
type: Class
subclass of: EC 3.1.26.13 (retroviral ribonuclease H) inhibitor
subclass of: anti-HIV-1 agent
textual definition: An entity which inhibits the activity of HIV-1 reverse transcriptase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: HIV-1 reverse transcriptase inhibitors
has_related_synonym: reverse transcriptase inhibitor
has_related_synonym: reverse transcriptase inhibitors
id: CHEBI:53756
in subset: 3 STAR

antispasmodic drug
type: Class
subclass of: muscle relaxant
textual definition: A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antispasmodics
id: CHEBI:53784
in subset: 3 STAR

mu-opioid receptor agonist
type: Class
subclass of: mu-opioid agent
subclass of: opioid receptor agonist
textual definition: A compound that exhibits agonist activity at the mu-opioid receptor.
imported from: chebi.owl
has_alternative_id: CHEBI:50136
has_obo_namespace: chebi_ontology
has_related_synonym: mu opioid agonist
has_related_synonym: mu-opioid agonists
has_related_synonym: mu-opioid receptor agonists
id: CHEBI:55322
in subset: 3 STAR

antidiarrhoeal drug
type: Class
subclass of: gastrointestinal drug
textual definition: Any drug found useful in the symptomatic treatment of diarrhoea.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidiarrheal
has_related_synonym: antidiarrheal agent
has_related_synonym: antidiarrheal agents
has_related_synonym: antidiarrheal drug
has_related_synonym: antidiarrheal drugs
has_related_synonym: antidiarrheals
has_related_synonym: antidiarrhoeal
has_related_synonym: antidiarrhoeal agent
has_related_synonym: antidiarrhoeal agents
has_related_synonym: antidiarrhoeal drugs
has_related_synonym: antidiarrhoeals
has_related_synonym: antiperistaltic
has_related_synonym: antiperistaltic agent
has_related_synonym: antiperistaltic agents
has_related_synonym: antiperistaltic drug
has_related_synonym: antiperistaltic drugs
has_related_synonym: antiperistaltics
id: CHEBI:55323
in subset: 3 STAR

gastrointestinal drug
type: Class
subclass of: drug
textual definition: A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: gastrointestinal agent
has_related_synonym: gastrointestinal agents
has_related_synonym: gastrointestinal drugs
id: CHEBI:55324
in subset: 3 STAR

vitamin K antagonist
type: Class
subclass of: antagonist
textual definition: A class of anticoagulants which act by inhibiting the action of vitamin K.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin K antagonists
id: CHEBI:55347
in subset: 3 STAR

neurokinin-1 receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the neurokinin-1 receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NK-1 receptor antagonist
has_related_synonym: NK-1 receptor antagonists
has_related_synonym: NK1 receptor antagonist
has_related_synonym: NK1 receptor antagonists
has_related_synonym: neurokinin-1 receptor antagonists
id: CHEBI:55350
in subset: 3 STAR

substance P receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the substance P receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: substance P receptor antagonists
id: CHEBI:55351
in subset: 3 STAR

antiseborrheic
type: Class
subclass of: dermatologic drug
textual definition: A drug or agent applied to the skin to control seborrhea or seborrheic dermatitis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antiseborrheic agent
has_related_synonym: antiseborrheic agents
has_related_synonym: antiseborrheic drug
has_related_synonym: antiseborrheics
id: CHEBI:59010
in subset: 3 STAR

EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor
type: Class
subclass of: EC 6.3.* (C-N bond-forming ligase) inhibitor
textual definition: Any inhibitor of an acid--D-amino-acid ligase (EC 6.3.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.2.* (acid--D-amino-acid ligase (peptide synthase)) inhibitor
has_related_synonym: EC 6.3.2.* (acid--D-amino-acid ligase (peptide synthase)) inhibitors
has_related_synonym: EC 6.3.2.* (acid--D-amino-acid ligase) inhibitors
has_related_synonym: EC 6.3.2.* (acid--amino-acid ligase) inhibitor
has_related_synonym: EC 6.3.2.* (acid--amino-acid ligase) inhibitors
has_related_synonym: EC 6.3.2.* [acid--D-amino-acid ligase (peptide synthase)] inhibitor
has_related_synonym: EC 6.3.2.* [acid--D-amino-acid ligase (peptide synthase)] inhibitors
has_related_synonym: EC 6.3.2.* inhibitor
has_related_synonym: EC 6.3.2.* inhibitors
has_related_synonym: acid--amino-acid ligase inhibitor
has_related_synonym: acid--amino-acid ligase inhibitors
has_related_synonym: peptide synthase inhibitor
has_related_synonym: peptide synthase inhibitors
id: CHEBI:59105
in subset: 3 STAR

EC 3.4.24.* (metalloendopeptidase) inhibitor
type: Class
subclass of: protease inhibitor
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a metalloendopeptidase (EC 3.4.24.*).
imported from: chebi.owl
has_alternative_id: CHEBI:76786
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.24.* (metalloendopeptidase) inhibitors
has_related_synonym: EC 3.4.24.* inhibitor
has_related_synonym: EC 3.4.24.* inhibitors
has_related_synonym: inhibitor of metalloendopeptidases
has_related_synonym: inhibitor of metalloendopeptidases (EC 3.4.24.*)
has_related_synonym: inhibitors of metalloendopeptidases
has_related_synonym: inhibitors of metalloendopeptidases (EC 3.4.24.*)
has_related_synonym: metalloendopeptidase (EC 3.4.24.*) inhibitor
has_related_synonym: metalloendopeptidase (EC 3.4.24.*) inhibitors
has_related_synonym: metalloendopeptidase inhibitors
id: CHEBI:59107
in subset: 3 STAR

antigen
type: Class
subclass of: biological role
textual definition: Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antigens
id: CHEBI:59132
in subset: 3 STAR

biomarker
type: Class
subclass of: indicator
textual definition: A substance used as an indicator of a biological state.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: biological marker
id: CHEBI:59163
in subset: 3 STAR

hapten
type: Class
subclass of: biological role
textual definition: Any substance capable of eliciting an immune response only when attached to a large carrier such as a protein. Examples include dinitrophenols; oligosaccharides; peptides; and heavy metals.
imported from: chebi.owl
has cross-reference: PMID:17875790
has cross-reference: PMID:17986299
has cross-reference: PMID:19101624
has cross-reference: PMID:291959
has cross-reference: PMID:3782019
has_obo_namespace: chebi_ontology
has_related_synonym: haptens
id: CHEBI:59174
in subset: 3 STAR

GnRH antagonist
type: Class
subclass of: hormone antagonist
textual definition: A chemical substance which inhibits the function of gonadotrophin-releasing hormone (GnRH).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GnRH antagonists
has_related_synonym: gonadotrophin-releasing hormone antagonist
has_related_synonym: gonadotrophin-releasing hormone antagonists
id: CHEBI:59229
in subset: 3 STAR

EC 3.4.21.* (serine endopeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the activity of a serine endopeptidase (EC 3.4.21.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.* (serine endopeptidase) inhibitors
has_related_synonym: EC 3.4.21.* inhibitor
has_related_synonym: EC 3.4.21.* inhibitors
has_related_synonym: inhibitor of serine endopeptidase (EC 3.4.21.*)
has_related_synonym: inhibitor of serine endopeptidase (EC 3.4.21.*)s
has_related_synonym: serine endopeptidase inhibitor
has_related_synonym: serine endopeptidase inhibitors
id: CHEBI:5924
in subset: 3 STAR

kappa-opioid receptor agonist
type: Class
subclass of: kappa-opioid agent
subclass of: opioid receptor agonist
textual definition: A compound that exhibits agonist activity at the kappa-opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: kappa-opioid agonist
has_related_synonym: kappa-opioid receptor agonists
id: CHEBI:59282
in subset: 3 STAR

delta-opioid receptor antagonist
type: Class
subclass of: delta-opioid agent
subclass of: opioid receptor antagonist
textual definition: Any compound that exhibits antagonist activity at the delta-opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: delta-opioid antagonist
has_related_synonym: delta-opioid antagonists
id: CHEBI:59283
in subset: 3 STAR

EC 1.14.13.132 (squalene monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.13.132 (squalene monooxygenase) inhibitors
has_related_synonym: squalene 2,3-oxidocyclase inhibitor
has_related_synonym: squalene 2,3-oxidocyclase inhibitors
has_related_synonym: squalene epoxidase inhibitor
has_related_synonym: squalene epoxidase inhibitors
has_related_synonym: squalene hydroxylase inhibitor
has_related_synonym: squalene hydroxylase inhibitors
has_related_synonym: squalene monooxygenase (EC 1.14.13.132) inhibitor
has_related_synonym: squalene monooxygenase (EC 1.14.13.132) inhibitors
has_related_synonym: squalene monooxygenase inhibitor
has_related_synonym: squalene monooxygenase inhibitors
has_related_synonym: squalene oxydocyclase inhibitor
has_related_synonym: squalene oxydocyclase inhibitors
has_related_synonym: squalene-2,3-epoxidase inhibitor
has_related_synonym: squalene-2,3-epoxidase inhibitors
has_related_synonym: squalene-2,3-epoxide cyclase inhibitor
has_related_synonym: squalene-2,3-epoxide cyclase inhibitors
id: CHEBI:59285
in subset: 3 STAR

EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of aromatic-L-amino-acid decarboxylase (EC 4.1.1.28).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 5-hydroxytryptophan decarboxylase inhibitor
has_related_synonym: 5-hydroxytryptophan decarboxylase inhibitors
has_related_synonym: DOPA decarboxylase inhibitor
has_related_synonym: DOPA decarboxylase inhibitors
has_related_synonym: EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitors
has_related_synonym: EC 4.1.1.28 inhibitor
has_related_synonym: EC 4.1.1.28 inhibitors
has_related_synonym: L-DOPA decarboxylase inhibitor
has_related_synonym: L-DOPA decarboxylase inhibitors
has_related_synonym: aromatic amino acid decarboxylase inhibitor
has_related_synonym: aromatic amino acid decarboxylase inhibitors
has_related_synonym: aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) inhibitor
has_related_synonym: aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) inhibitors
has_related_synonym: aromatic-L-amino-acid decarboxylase inhibitor
has_related_synonym: aromatic-L-amino-acid decarboxylase inhibitors
has_related_synonym: hydroxytryptophan decarboxylase inhibitor
has_related_synonym: hydroxytryptophan decarboxylase inhibitors
has_related_synonym: tryptophan decarboxylase inhibitor
has_related_synonym: tryptophan decarboxylase inhibitors
id: CHEBI:59321
in subset: 3 STAR

EC 3.4.13.* (dipeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the action of a dipeptidase (EC 3.4.13.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.13.* (dipeptidase) inhibitors
has_related_synonym: EC 3.4.13.* inhibitor
has_related_synonym: EC 3.4.13.* inhibitors
has_related_synonym: dipeptidase inhibitor
has_related_synonym: dipeptidase inhibitors
id: CHEBI:59499
in subset: 3 STAR

DNA synthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: Any substance that inhibits the synthesis of DNA.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: DNA synthesis inhibitors
id: CHEBI:59517
in subset: 3 STAR

phosphoantigen
type: Class
subclass of: antigen
textual definition: Any antigen that is a phosphorylated microbial metabolite which activates an immune response in humans.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phosphoantigens
id: CHEBI:59544
in subset: 3 STAR

EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of serine palmitoyltransferase (EC 2.3.1.50).
imported from: chebi.owl
has cross-reference: Wikipedia:Serine_C-palmitoyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: 3-oxosphinganine synthetase inhibitor
has_related_synonym: 3-oxosphinganine synthetase inhibitors
has_related_synonym: EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitors
has_related_synonym: EC 2.3.1.50 inhibitor
has_related_synonym: EC 2.3.1.50 inhibitors
has_related_synonym: SPT inhibitor
has_related_synonym: SPT inhibitors
has_related_synonym: acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitor
has_related_synonym: acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitors
has_related_synonym: palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitor
has_related_synonym: palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitors
has_related_synonym: serine C-palmitoyltransferase (EC 2.3.1.50) inhibitor
has_related_synonym: serine C-palmitoyltransferase (EC 2.3.1.50) inhibitors
has_related_synonym: serine C-palmitoyltransferase inhibitor
has_related_synonym: serine C-palmitoyltransferase inhibitors
has_related_synonym: serine palmitoyltransferase inhibitor
has_related_synonym: serine palmitoyltransferase inhibitors
id: CHEBI:59647
in subset: 3 STAR

EC 2.4.1.16 (chitin synthase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of chitin synthase (EC 2.4.1.16).
imported from: chebi.owl
has cross-reference: Wikipedia:Chitin_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.16 (chitin synthase) inhibitors
has_related_synonym: EC 2.4.1.16 inhibitor
has_related_synonym: EC 2.4.1.16 inhibitors
has_related_synonym: UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitor
has_related_synonym: UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitors
has_related_synonym: chitin synthase (EC 2.4.1.16) inhibitor
has_related_synonym: chitin synthase (EC 2.4.1.16) inhibitors
has_related_synonym: chitin synthase inhibitor
has_related_synonym: chitin synthase inhibitors
has_related_synonym: chitin synthesis inhibitor
has_related_synonym: chitin synthesis inhibitors
has_related_synonym: chitin synthetase inhibitor
has_related_synonym: chitin synthetase inhibitors
has_related_synonym: chitin-UDP N-acetylglucosaminyltransferase inhibitor
has_related_synonym: chitin-UDP N-acetylglucosaminyltransferase inhibitors
has_related_synonym: chitin-UDP acetyl-glucosaminyl transferase inhibitor
has_related_synonym: chitin-UDP acetyl-glucosaminyl transferase inhibitors
has_related_synonym: chitin-uridine diphosphate acetylglucosaminyltransferase inhibitor
has_related_synonym: chitin-uridine diphosphate acetylglucosaminyltransferase inhibitors
has_related_synonym: trans-N-acetylglucosaminosylase inhibitor
has_related_synonym: trans-N-acetylglucosaminosylase inhibitors
id: CHEBI:59672
in subset: 3 STAR

vasopressin receptor antagonist
type: Class
subclass of: hormone antagonist
textual definition: Any drug which blocks vasopressin receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidiuretic hormone inhibitor
has_related_synonym: antidiuretic hormone inhibitors
has_related_synonym: arginine vasopressin receptor antagonist
has_related_synonym: arginine vasopressin receptor antagonists
has_related_synonym: argipressin receptor antagonist
has_related_synonym: argipressin receptor antagonists
has_related_synonym: vasopressin receptor antagonists
id: CHEBI:59680
in subset: 3 STAR

antipruritic drug
type: Class
subclass of: dermatologic drug
textual definition: A drug, usually applied topically, that relieves pruritus (itching).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-itching drug
has_related_synonym: anti-itching drugs
has_related_synonym: antipruritic agent
has_related_synonym: antipruritic agents
has_related_synonym: antipruritic drugs
id: CHEBI:59683
in subset: 3 STAR

vasopressin receptor agonist
type: Class
subclass of: hormone agonist
textual definition: Any drug which binds to vasopressin receptors and triggers a response.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidiuretic hormone agonist
has_related_synonym: antidiuretic hormone agonists
has_related_synonym: arginine vasopressin receptor agonist
has_related_synonym: arginine vasopressin receptor agonists
has_related_synonym: argipressin receptor agonist
has_related_synonym: argipressin receptor agonists
has_related_synonym: vasopressin receptor agonists
id: CHEBI:59727
in subset: 3 STAR

electrophilic reagent
type: Class
subclass of: reagent
subclass of: Lewis acid
textual definition: A reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: electrophile
has_related_synonym: electrophiles
has_related_synonym: electrophilic reagents
id: CHEBI:59739
in subset: 3 STAR

nucleophilic reagent
type: Class
subclass of: reagent
subclass of: Lewis base
textual definition: A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nucleophile
has_related_synonym: nucleophiles
has_related_synonym: nucleophilic reagents
id: CHEBI:59740
in subset: 3 STAR

chromatographic reagent
type: Class
subclass of: reagent
textual definition: A reagent used to improve selectivity in chromatographic analyses or separations, e.g. by formation of a derivative or by modification of the mobile phase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: derivatising reagents
has_related_synonym: derivatizing reagent
has_related_synonym: derivatizing reagents
id: CHEBI:59745
in subset: 3 STAR

bolaamphiphile
type: Class
subclass of: surfactant
textual definition: A surfactant molecule with hydrophilic groups at both ends of a hydrophobic hydrocarbon chain
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: alpha-omega-type surfactant
has_related_synonym: bolaamphiphiles
has_related_synonym: bolaform surfactant
has_related_synonym: bolaphile
id: CHEBI:59752
in subset: 3 STAR

progestin
type: Class
subclass of: progestogen
textual definition: A synthetic progestogen.
imported from: chebi.owl
has cross-reference: Wikipedia:Progestin
has_obo_namespace: chebi_ontology
has_related_synonym: progestins
id: CHEBI:59826
in subset: 3 STAR

antihyperplasia drug
type: Class
subclass of: drug
textual definition: A drug used for the treatment of hyperplasia (increaced cell production within an organ or tissue).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antihypergenesis drug
has_related_synonym: antihypergenesis drugs
has_related_synonym: antihyperplasia drugs
has_related_synonym: antihyperplastic
id: CHEBI:59844
in subset: 3 STAR

depigmentation drug
type: Class
subclass of: drug
textual definition: Any drug used to depigment skin, normally by decreasing the excretion of melanin from melanocytes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: depigmentation agent
has_related_synonym: depigmentation agents
has_related_synonym: depigmentation drugs
has_related_synonym: depigmentor
has_related_synonym: depigmentors
id: CHEBI:59864
in subset: 3 STAR

HIV fusion inhibitor
type: Class
subclass of: antiviral drug
subclass of: anti-HIV agent
textual definition: A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS.
imported from: chebi.owl
has cross-reference: PMID:22470838
has cross-reference: Wikipedia:Entry_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: HIV entry inhibitor
has_related_synonym: HIV entry inhibitors
has_related_synonym: HIV fusion inhibitors
id: CHEBI:59886
in subset: 3 STAR

EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
type: Class
subclass of: antiviral agent
subclass of: DNA polymerase inhibitor
textual definition: A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce.
imported from: chebi.owl
has cross-reference: Wikipedia:Reverse-transcriptase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: DNA nucleotidyltransferase (RNA-directed) inhibitor
has_related_synonym: DNA nucleotidyltransferase (RNA-directed) inhibitors
has_related_synonym: EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors
has_related_synonym: EC 2.7.7.49 inhibitor
has_related_synonym: EC 2.7.7.49 inhibitors
has_related_synonym: RNA revertase inhibitor
has_related_synonym: RNA revertase inhibitors
has_related_synonym: RNA-dependent DNA polymerase inhibitor
has_related_synonym: RNA-dependent DNA polymerase inhibitors
has_related_synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor
has_related_synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors
has_related_synonym: RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor
has_related_synonym: RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors
has_related_synonym: RNA-directed DNA polymerase inhibitor
has_related_synonym: RNA-directed DNA polymerase inhibitors
has_related_synonym: RNA-instructed DNA polymerase inhibitor
has_related_synonym: RNA-instructed DNA polymerase inhibitors
has_related_synonym: RT inhibitor
has_related_synonym: RT inhibitors
has_related_synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor
has_related_synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors
has_related_synonym: reverse transcriptase inhibitor
has_related_synonym: reverse transcriptase inhibitors
has_related_synonym: revertase inhibitor
has_related_synonym: revertase inhibitors
has_related_synonym: telomerase inhibitor
has_related_synonym: telomerase inhibitors
id: CHEBI:59897
in subset: 3 STAR

amphiphile
type: Class
subclass of: surfactant
textual definition: A surfactant molecule possessing both hydrophilic and lipophilic properties.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: amphiphiles
id: CHEBI:59941
in subset: 3 STAR

EC 1.14.18.1 (tyrosinase) inhibitor
type: Class
subclass of: EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor
textual definition: Any EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of tyrosinase (monophenol monooxygenase), EC 1.14.18.1, an enzyme that catalyses the oxidation of phenols (such as tyrosine) and is widespread in plants and animals.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.18.1 (tyrosinase) inhibitors
has_related_synonym: EC 1.14.18.1 inhibitor
has_related_synonym: EC 1.14.18.1 inhibitors
has_related_synonym: L-tyrosine,L-dopa:oxygen oxidoreductase inhibitor
has_related_synonym: L-tyrosine,L-dopa:oxygen oxidoreductase inhibitors
has_related_synonym: NN-acetyl-6-hydroxytryptophan oxidase inhibitor
has_related_synonym: NN-acetyl-6-hydroxytryptophan oxidase inhibitors
has_related_synonym: O-diphenol:O2 oxidoreductase inhibitor
has_related_synonym: O-diphenol:O2 oxidoreductase inhibitors
has_related_synonym: cresolase inhibitor
has_related_synonym: cresolase inhibitors
has_related_synonym: monophenol dihydroxyphenylalanine:oxygen oxidoreductase inhibitor
has_related_synonym: monophenol dihydroxyphenylalanine:oxygen oxidoreductase inhibitors
has_related_synonym: monophenol monooxidase inhibitor
has_related_synonym: monophenol monooxidase inhibitors
has_related_synonym: monophenol monooxygenase inhibitor
has_related_synonym: monophenol monooxygenase inhibitors
has_related_synonym: monophenol oxidase inhibitor
has_related_synonym: monophenol oxidase inhibitors
has_related_synonym: monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase inhibitor
has_related_synonym: monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase inhibitors
has_related_synonym: monophenolase inhibitor
has_related_synonym: monophenolase inhibitors
has_related_synonym: phenol oxidase inhibitor
has_related_synonym: phenol oxidase inhibitors
has_related_synonym: phenolase inhibitor
has_related_synonym: phenolase inhibitors
has_related_synonym: tyrosinase (EC 1.14.18.1) inhibitor
has_related_synonym: tyrosinase (EC 1.14.18.1) inhibitors
has_related_synonym: tyrosinase inhibitor
has_related_synonym: tyrosinase inhibitors
has_related_synonym: tyrosine-dopa oxidase inhibitor
has_related_synonym: tyrosine-dopa oxidase inhibitors
id: CHEBI:59997
in subset: 3 STAR

chemical substance
type: Class
subclass of: chemical entity
textual definition: A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Chemische Substanz
id: CHEBI:59999
in subset: 3 STAR

EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
textual definition: An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of Ca(2+)-transporting ATPase (EC 3.6.3.8).
imported from: chebi.owl
has cross-reference: Wikipedia:Ca(2%2B)-transporting_atpase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP phosphohydrolase (Ca(2+)-transporting) inhibitor
has_related_synonym: ATP phosphohydrolase (Ca(2+)-transporting) inhibitors
has_related_synonym: Ca(2+)-pumping ATPase inhibitor
has_related_synonym: Ca(2+)-pumping ATPase inhibitors
has_related_synonym: Ca(2+)-transporting ATPase (EC 3.6.3.8) inhibitor
has_related_synonym: Ca(2+)-transporting ATPase (EC 3.6.3.8) inhibitors
has_related_synonym: Ca(2+)-transporting ATPase inhibitor
has_related_synonym: Ca(2+)-transporting ATPase inhibitors
has_related_synonym: EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitors
has_related_synonym: SERCA inhibitor
has_related_synonym: SERCA inhibitors
has_related_synonym: calcium pump inhibitor
has_related_synonym: calcium pump inhibitors
has_related_synonym: plasma membrane Ca-ATPase inhibitor
has_related_synonym: plasma membrane Ca-ATPase inhibitors
has_related_synonym: sarco(endo)plasmic reticulum Ca(2+)-ATPase inhibitor
has_related_synonym: sarco(endo)plasmic reticulum Ca(2+)-ATPase inhibitors
has_related_synonym: sarcoplasmic reticulum ATPase inhibitor
has_related_synonym: sarcoplasmic reticulum ATPase inhibitors
id: CHEBI:60186
in subset: 3 STAR

mimotope
type: Class
subclass of: biological role
textual definition: Any macromolecule whose structure mimics that of an epitope. When applied to immunisation, a mimotope induces the desired antibody specificities exclusively based on the principle of molecular mimicry.
imported from: chebi.owl
has cross-reference: PMID:17825923
has cross-reference: PMID:18228183
has cross-reference: PMID:19344285
has_obo_namespace: chebi_ontology
has_related_synonym: antigenic determinant mimic
has_related_synonym: epitope mimic
has_related_synonym: mimeotope
has_related_synonym: mimeotope function
has_related_synonym: mimeotope role
has_related_synonym: mimetope
has_related_synonym: mimotope function
has_related_synonym: mimotope role
id: CHEBI:60218
in subset: 3 STAR

EC 3.4.* (hydrolases acting on peptide bond) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*).
imported from: chebi.owl
has_alternative_id: CHEBI:76763
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.* (hydrolase acting on peptide bond) inhibitor
has_related_synonym: EC 3.4.* (hydrolase acting on peptide bonds) inhibitors
has_related_synonym: EC 3.4.* (hydrolases acting on peptide bond) inhibitors
has_related_synonym: EC 3.4.* (peptidase) inhibitor
has_related_synonym: EC 3.4.* (peptidase) inhibitors
has_related_synonym: EC 3.4.* inhibitor
has_related_synonym: EC 3.4.* inhibitors
has_related_synonym: inhibitor of hydrolases acting on peptide bond (EC 3.4.*)
has_related_synonym: inhibitors of hydrolases acting on peptide bond (EC 3.4.*)
has_related_synonym: peptidase inhibitors
has_related_synonym: protease inhibitor
has_related_synonym: protease inhibitors
id: CHEBI:60258
in subset: 3 STAR

EC 3.5.1.2 (glutaminase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: Any EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of a glutaminase (EC 3.5.1.2) and thus the generation of glutamate from glutamine.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.2 (glutaminase) inhibitors
has_related_synonym: EC 3.5.1.2 inhibitor
has_related_synonym: EC 3.5.1.2 inhibitors
has_related_synonym: L-glutaminase inhibitor
has_related_synonym: L-glutaminase inhibitors
has_related_synonym: L-glutamine amidohydrolase inhibitor
has_related_synonym: L-glutamine amidohydrolase inhibitors
has_related_synonym: glutaminase (EC 3.5.1.2) inhibitor
has_related_synonym: glutaminase (EC 3.5.1.2) inhibitors
has_related_synonym: glutaminase I inhibitor
has_related_synonym: glutaminase I inhibitors
has_related_synonym: glutaminase inhibitor
has_related_synonym: glutaminase inhibitors
has_related_synonym: glutamine aminohydrolase inhibitor
has_related_synonym: glutamine aminohydrolase inhibitors
id: CHEBI:60280
in subset: 3 STAR

thyroid hormone
type: Class
subclass of: hormone
textual definition: Any hormone produced by the thyroid gland
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: thyroid hormones
id: CHEBI:60311
in subset: 3 STAR

phenoxy herbicide
type: Class
subclass of: herbicide
textual definition: Any member of the class of herbicides whose members contain a phenoxy or substituted phenoxy group.
imported from: chebi.owl
has cross-reference: Wikipedia:Phenoxy_herbicide
has_obo_namespace: chebi_ontology
has_related_synonym: phenoxy herbicides
id: CHEBI:60575
in subset: 3 STAR

opioid agent
type: Class
subclass of: neurotransmitter agent
textual definition: Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: opioid agents
id: CHEBI:60598
in subset: 3 STAR

mu-opioid agent
type: Class
subclass of: opioid agent
textual definition: Any agent that acts on a mu-opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mu-opioid agents
id: CHEBI:60599
in subset: 3 STAR

delta-opioid agent
type: Class
subclass of: opioid agent
textual definition: Any agent that acts on a delta-opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: delta-opioid agents
id: CHEBI:60601
in subset: 3 STAR

kappa-opioid agent
type: Class
subclass of: opioid agent
textual definition: Any agent that acts on a kappa-opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: kappa-opioid agents
id: CHEBI:60603
in subset: 3 STAR

opioid receptor antagonist
type: Class
subclass of: antagonist
subclass of: opioid agent
textual definition: An agent that binds to but does not activate an opioid receptor thereby blocking the actions of endogenous or exogenous opioid receptor agonists.
imported from: chebi.owl
has cross-reference: Wikipedia:Opioid_antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: opiate antagonist
has_related_synonym: opiate antagonists
has_related_synonym: opioid antagonist
has_related_synonym: opioid antagonists
has_related_synonym: opioid receptor antagonists
id: CHEBI:60605
in subset: 3 STAR

opioid receptor agonist
type: Class
subclass of: agonist
subclass of: opioid agent
textual definition: An agent that selectively binds to and activates an opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: opiate agonist
has_related_synonym: opiate agonists
has_related_synonym: opioid agonist
has_related_synonym: opioid agonists
has_related_synonym: opioid receptor agonists
id: CHEBI:60606
in subset: 3 STAR

NMDA receptor antagonist
type: Class
subclass of: excitatory amino acid antagonist
textual definition: Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
imported from: chebi.owl
has_alternative_id: CHEBI:60797
has_obo_namespace: chebi_ontology
has_related_synonym: N-methyl-D-aspartate receptor antagonist
has_related_synonym: N-methyl-D-aspartate receptor antagonists
has_related_synonym: NMDA receptor antagonists
has_related_synonym: NMDAR antagonist
has_related_synonym: NMDAR antagonists
id: CHEBI:60643
in subset: 3 STAR

chiral reagent
type: Class
subclass of: reagent
textual definition: A chiral compound used to induce stereoselectivity into a reaction.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:60646
in subset: 3 STAR

glucagon receptor antagonist
type: Class
subclass of: hormone antagonist
textual definition: An agent which blocks glucagon receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glucagon receptor antagonists
id: CHEBI:60649
in subset: 3 STAR

EC 4.2.1.20 (tryptophan synthase) inhibitor
type: Class
subclass of: EC 4.2.1.* (hydro-lyases) inhibitor
textual definition: An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of tryptophan synthase (EC 4.2.1.20).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.2.1.20 (tryptophan synthase) inhibitors
has_related_synonym: EC 4.2.1.20 inhibitor
has_related_synonym: EC 4.2.1.20 inhibitors
has_related_synonym: L-serine hydro-lyase (adding indoleglycerol-phosphate) inhibitor
has_related_synonym: L-serine hydro-lyase (adding indoleglycerol-phosphate) inhibitors
has_related_synonym: L-tryptophan synthetase inhibitor
has_related_synonym: L-tryptophan synthetase inhibitors
has_related_synonym: indoleglycerol phosphate aldolase inhibitor
has_related_synonym: indoleglycerol phosphate aldolase inhibitors
has_related_synonym: tryptophan desmolase inhibitor
has_related_synonym: tryptophan desmolase inhibitors
has_related_synonym: tryptophan synthase (EC 4.2.1.20) inhibitor
has_related_synonym: tryptophan synthase (EC 4.2.1.20) inhibitors
has_related_synonym: tryptophan synthase inhibitor
has_related_synonym: tryptophan synthase inhibitors
has_related_synonym: tryptophan synthetase inhibitor
has_related_synonym: tryptophan synthetase inhibitors
id: CHEBI:60688
in subset: 3 STAR

affinity label
type: Class
subclass of: enzyme inhibitor
textual definition: An enzyme inhibitor, generally irreversible, that is similar in structure to a particular substrate for a specific enzyme.
imported from: chebi.owl
has cross-reference: Wikipedia:Affinity_label
has_obo_namespace: chebi_ontology
has_related_synonym: affinity labels
id: CHEBI:60788
in subset: 3 STAR

excitatory amino acid antagonist
type: Class
subclass of: antagonist
textual definition: Any substance which inhibits the action of receptors for excitatory amino acids.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EAA receptor antagonist
has_related_synonym: EAA receptor antagonists
has_related_synonym: excitatory amino acid antagonists
has_related_synonym: excitatory amino acid receptor antagonist
has_related_synonym: excitatory amino acid receptor antagonists
id: CHEBI:60798
in subset: 3 STAR

anaesthesia adjuvant
type: Class
subclass of: adjuvant
textual definition: Any substance that possesses little anaesthetic effect by itself, but which enhances or potentiates the anaesthetic action of other drugs when given at the same time.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anaesthesia adjuvants
has_related_synonym: anaesthestic adjuvant
has_related_synonym: anaesthestic adjuvants
id: CHEBI:60807
in subset: 3 STAR

adjuvant
type: Class
subclass of: pharmaceutical
textual definition: Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adjuvants
id: CHEBI:60809
in subset: 3 STAR

immunogen
type: Class
subclass of: antigen
textual definition: An antigen capable, on its own, of inducing an immune response.
imported from: chebi.owl
has cross-reference: PMID:19152635
has cross-reference: PMID:19328011
has cross-reference: PMID:19397283
has_obo_namespace: chebi_ontology
id: CHEBI:60816
in subset: 3 STAR

tubulin modulator
type: Class
subclass of: pharmacological role
textual definition: Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: tubulin modulators
id: CHEBI:60832
in subset: 3 STAR

EC 2.5.1.9 (riboflavin synthase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that inhibits the action of riboflavin synthase (EC 2.5.1.9).
imported from: chebi.owl
has cross-reference: Wikipedia:Riboflavin_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase inhibitor
has_related_synonym: 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase inhibitors
has_related_synonym: EC 2.5.1.9 (riboflavin synthase) inhibitors
has_related_synonym: EC 2.5.1.9 inhibitor
has_related_synonym: EC 2.5.1.9 inhibitors
has_related_synonym: heavy riboflavin synthase inhibitor
has_related_synonym: heavy riboflavin synthase inhibitors
has_related_synonym: light riboflavin synthase inhibitor
has_related_synonym: light riboflavin synthase inhibitors
has_related_synonym: riboflavin synthase (EC 2.5.1.9) inhibitor
has_related_synonym: riboflavin synthase (EC 2.5.1.9) inhibitors
has_related_synonym: riboflavin synthase inhibitor
has_related_synonym: riboflavin synthase inhibitors
has_related_synonym: riboflavin synthetase inhibitor
has_related_synonym: riboflavin synthetase inhibitors
has_related_synonym: riboflavine synthase inhibitor
has_related_synonym: riboflavine synthase inhibitors
has_related_synonym: riboflavine synthetase inhibitor
has_related_synonym: riboflavine synthetase inhibitors
id: CHEBI:60901
in subset: 3 STAR

nephrotoxin
type: Class
subclass of: toxin
subclass of: nephrotoxic agent
textual definition: A toxin that is produced by a biological organism such as a microbe, animal or plant which interferes with the function of the kidney in animals.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nephrotoxins
id: CHEBI:61015
in subset: 3 STAR

angiotensin receptor antagonist
type: Class
subclass of: hormone antagonist
textual definition: A hormone antagonist that blocks angiotensin receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: angiotensin receptor antagonists
id: CHEBI:61016
in subset: 3 STAR

bile therapy drug
type: Class
subclass of: drug
textual definition: A drug used in the treatment of bile or liver disorders.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bile therapy agent
has_related_synonym: bile therapy agents
has_related_synonym: bile therapy drugs
id: CHEBI:61026
in subset: 3 STAR

EC 3.5.1.98 (histone deacetylase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
imported from: chebi.owl
has cross-reference: Wikipedia:Histone_deacetylase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.98 (histone deacetylase) inhibitors
has_related_synonym: EC 3.5.1.98 inhibitor
has_related_synonym: EC 3.5.1.98 inhibitors
has_related_synonym: HDAC inhibitor
has_related_synonym: HDAC inhibitors
has_related_synonym: HDACi
has_related_synonym: HDACis
has_related_synonym: HDI
has_related_synonym: HDIs
has_related_synonym: histone amidohydrolase inhibitor
has_related_synonym: histone amidohydrolase inhibitors
has_related_synonym: histone deacetylase (EC 3.5.1.98) inhibitor
has_related_synonym: histone deacetylase (EC 3.5.1.98) inhibitors
has_related_synonym: histone deacetylase inhibitor
has_related_synonym: histone deacetylase inhibitors
id: CHEBI:61115
in subset: 3 STAR

inositol phosphorylceramide synthase inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: An enzyme inhibitor that inhibits the action of inositol phosphorylceramide synthase.
imported from: chebi.owl
has cross-reference: PMID:17420564
has cross-reference: PMID:17420565
has cross-reference: PMID:19644518
has cross-reference: PMID:19644519
has cross-reference: PMID:19662087
has_obo_namespace: chebi_ontology
id: CHEBI:61774
in subset: 3 STAR

EC 1.14.13.39 (nitric oxide synthase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of nitric oxide synthase (EC 1.14.13.39).
imported from: chebi.owl
has cross-reference: Wikipedia:Nitric_oxide_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.13.39 (nitric oxide synthase) inhibitors
has_related_synonym: EC 1.14.13.39 inhibitor
has_related_synonym: EC 1.14.13.39 inhibitors
has_related_synonym: NADPH-diaphorase inhibitor
has_related_synonym: NADPH-diaphorase inhibitors
has_related_synonym: NO synthase inhibitor
has_related_synonym: NO synthase inhibitors
has_related_synonym: endothelium-derived relaxation factor-forming enzyme inhibitor
has_related_synonym: endothelium-derived relaxation factor-forming enzyme inhibitors
has_related_synonym: endothelium-derived relaxing factor synthase inhibitor
has_related_synonym: endothelium-derived relaxing factor synthase inhibitors
has_related_synonym: nitric oxide synthase (EC 1.14.13.39) inhibitor
has_related_synonym: nitric oxide synthase (EC 1.14.13.39) inhibitors
has_related_synonym: nitric oxide synthase inhibitor
has_related_synonym: nitric oxide synthase inhibitors
has_related_synonym: nitric oxide synthetase inhibitor
has_related_synonym: nitric oxide synthetase inhibitors
has_related_synonym: nitric-oxide synthetase inhibitor
has_related_synonym: nitric-oxide synthetase inhibitors
id: CHEBI:61908
in subset: 3 STAR

microtubule-stabilising agent
type: Class
subclass of: tubulin modulator
textual definition: Any substance that interacts with tubulin to promote polymerisation of microtubules.
imported from: chebi.owl
has cross-reference: PMID:11470606
has_obo_namespace: chebi_ontology
has_related_synonym: microtubule stabilising agent
has_related_synonym: microtubule stabilising role
has_related_synonym: microtubule stabilizing agent
has_related_synonym: microtubule stabilizing agents
has_related_synonym: microtubule stabilizing role
has_related_synonym: microtubule-stabilising agents
has_related_synonym: microtubule-stabilizing agent
id: CHEBI:61950
in subset: 3 STAR

microtubule-destabilising agent
type: Class
subclass of: tubulin modulator
subclass of: antimitotic
textual definition: Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
imported from: chebi.owl
has cross-reference: PMID:17099073
has_obo_namespace: chebi_ontology
has_related_synonym: microtubule destabilising agent
has_related_synonym: microtubule destabilising agents
has_related_synonym: microtubule destabilising role
has_related_synonym: microtubule destabilizing role
has_related_synonym: microtubule-destabilising agents
has_related_synonym: microtubule-destabilizing agent
has_related_synonym: microtubule-destabilizing agents
id: CHEBI:61951
in subset: 3 STAR

metabotropic glutamate receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates a metabotropic glutamate receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mGluRs agonist
has_related_synonym: metabotropic glutamate receptor agonists
id: CHEBI:61966
in subset: 3 STAR

acyl donor
type: Class
subclass of: donor
textual definition: Any donor that can transfer acyl groups between molecular entities.
imported from: chebi.owl
has cross-reference: PMID:16100120
has cross-reference: PMID:19052863
has_obo_namespace: chebi_ontology
id: CHEBI:62049
in subset: 3 STAR

EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor
type: Class
subclass of: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
textual definition: An EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor that interferes with the action of any glutamate synthase.
imported from: chebi.owl
has cross-reference: Wikipedia:Glutamate_synthase_(ferredoxin)
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitors
has_related_synonym: EC 1.4.7.1 inhibitor
has_related_synonym: EC 1.4.7.1 inhibitors
has_related_synonym: L-glutamate:ferredoxin oxidoreductase (transaminating) inhibitor
has_related_synonym: L-glutamate:ferredoxin oxidoreductase (transaminating) inhibitors
has_related_synonym: ferredoxin-dependent glutamate synthase inhibitor
has_related_synonym: ferredoxin-dependent glutamate synthase inhibitors
has_related_synonym: ferredoxin-glutamate synthase inhibitor
has_related_synonym: ferredoxin-glutamate synthase inhibitors
has_related_synonym: glutamate synthase (ferredoxin) (EC 1.4.7.1) inhibitor
has_related_synonym: glutamate synthase (ferredoxin) (EC 1.4.7.1) inhibitors
has_related_synonym: glutamate synthase (ferredoxin) inhibitor
has_related_synonym: glutamate synthase (ferredoxin) inhibitors
has_related_synonym: glutamate synthase (ferredoxin-dependent) inhibitor
has_related_synonym: glutamate synthase (ferredoxin-dependent) inhibitors
has_related_synonym: glutamate synthase inhibitor
has_related_synonym: glutamate synthase inhibitors
id: CHEBI:62089
in subset: 3 STAR

allelochemical
type: Class
subclass of: metabolite
textual definition: A class of secondary metabolites developed by many plants to influence the behaviour, growth or survival of herbivores, and thus acting as a defence against herbivory.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: allelochemicals
id: CHEBI:62215
in subset: 3 STAR

EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
type: Class
subclass of: tyrosine kinase inhibitor
subclass of: EC 2.7.10.* (protein-tyrosine kinase) inhibitor
textual definition: An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Anaplastic_lymphoma_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: AATK inhibitor
has_related_synonym: AATYK inhibitor
has_related_synonym: AATYK2 inhibitor
has_related_synonym: AATYK3 inhibitor
has_related_synonym: ACH inhibitor
has_related_synonym: ALK inhibitor
has_related_synonym: ALK inhibitors
has_related_synonym: ARK inhibitor
has_related_synonym: ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitor
has_related_synonym: ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitors
has_related_synonym: AXL inhibitor
has_related_synonym: BRT inhibitor
has_related_synonym: Bek inhibitor
has_related_synonym: Bfgfr inhibitor
has_related_synonym: Bsk inhibitor
has_related_synonym: C-FMS inhibitor
has_related_synonym: CAK inhibitor
has_related_synonym: CCK4 inhibitor
has_related_synonym: CD115 inhibitor
has_related_synonym: CD135 inhibitor
has_related_synonym: CDw135 inhibitor
has_related_synonym: CFD1 inhibitor
has_related_synonym: CKIT inhibitor
has_related_synonym: CSF1R inhibitor
has_related_synonym: Cek1 inhibitor
has_related_synonym: Cek10 inhibitor
has_related_synonym: Cek11 inhibitor
has_related_synonym: Cek2 inhibitor
has_related_synonym: Cek3 inhibitor
has_related_synonym: Cek5 inhibitor
has_related_synonym: Cek6 inhibitor
has_related_synonym: Cek7 inhibitor
has_related_synonym: DAlk inhibitor
has_related_synonym: DDR1 inhibitor
has_related_synonym: DDR2 inhibitor
has_related_synonym: DKFZp434C1418 inhibitor
has_related_synonym: DRT inhibitor
has_related_synonym: DTK inhibitor
has_related_synonym: Dek inhibitor
has_related_synonym: Drosophila Eph kinase inhibitor
has_related_synonym: EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitors
has_related_synonym: EC 2.7.10.1 inhibitor
has_related_synonym: EC 2.7.10.1 inhibitors
has_related_synonym: ECK inhibitor
has_related_synonym: EDDR1 inhibitor
has_related_synonym: EGFR inhibitor
has_related_synonym: EPH inhibitor
has_related_synonym: EPHA1 inhibitor
has_related_synonym: EPHA2 inhibitor
has_related_synonym: EPHA6 inhibitor
has_related_synonym: EPHA7 inhibitor
has_related_synonym: EPHA8 inhibitor
has_related_synonym: EPHB1 inhibitor
has_related_synonym: EPHB2 inhibitor
has_related_synonym: EPHB3 inhibitor
has_related_synonym: EPHB4 inhibitor
has_related_synonym: EPHT inhibitor
has_related_synonym: EPHT2 inhibitor
has_related_synonym: EPHT3 inhibitor
has_related_synonym: EPHX inhibitor
has_related_synonym: ERBB inhibitor
has_related_synonym: ERBB1 inhibitor
has_related_synonym: ERBB2 inhibitor
has_related_synonym: ERBB3 inhibitor
has_related_synonym: ERBB4 inhibitor
has_related_synonym: ERK inhibitor
has_related_synonym: Ebk inhibitor
has_related_synonym: Eek inhibitor
has_related_synonym: Ehk2 inhibitor
has_related_synonym: Ehk3 inhibitor
has_related_synonym: Elk inhibitor
has_related_synonym: EphB5 inhibitor
has_related_synonym: Eyk inhibitor

signalling molecule
type: Class
subclass of: molecular messenger
textual definition: A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: signal molecule
has_related_synonym: signal molecules
has_related_synonym: signaling molecule
has_related_synonym: signaling molecules
has_related_synonym: signalling molecules
id: CHEBI:62488
in subset: 3 STAR

EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of sphingosine N-acyltransferase (EC 2.3.1.24).
imported from: chebi.owl
has cross-reference: Wikipedia:Sphingosine_N-acyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitors
has_related_synonym: EC 2.3.1.24 inhibitor
has_related_synonym: EC 2.3.1.24 inhibitors
has_related_synonym: acyl-CoA:sphingosine N-acyltransferase inhibitor
has_related_synonym: acyl-CoA:sphingosine N-acyltransferase inhibitors
has_related_synonym: ceramide synthase inhibitor
has_related_synonym: ceramide synthase inhibitors
has_related_synonym: ceramide synthetase inhibitor
has_related_synonym: ceramide synthetase inhibitors
has_related_synonym: sphingosine N-acyltransferase (EC 2.3.1.24) inhibitor
has_related_synonym: sphingosine N-acyltransferase (EC 2.3.1.24) inhibitors
has_related_synonym: sphingosine N-acyltransferase inhibitor
has_related_synonym: sphingosine N-acyltransferase inhibitors
has_related_synonym: sphingosine acyltransferase inhibitor
has_related_synonym: sphingosine acyltransferase inhibitors
id: CHEBI:62530
in subset: 3 STAR

EC 4.2.1.3 (aconitate hydratase) inhibitor
type: Class
subclass of: EC 4.2.1.* (hydro-lyases) inhibitor
textual definition: An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the function of aconitase (EC 4.2.1.3).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 2-methylaconitate hydratase inhibitor
has_related_synonym: 2-methylaconitate hydratase inhibitors
has_related_synonym: 4.2.1.3 inhibitor
has_related_synonym: 4.2.1.3 inhibitors
has_related_synonym: AcnB inhibitor
has_related_synonym: AcnB inhibitors
has_related_synonym: EC 4.2.1.3 (aconitate hydratase) inhibitors
has_related_synonym: aconitase inhibitor
has_related_synonym: aconitase inhibitors
has_related_synonym: aconitate hydratase (EC 4.2.1.3) inhibitor
has_related_synonym: aconitate hydratase (EC 4.2.1.3) inhibitors
has_related_synonym: aconitate hydratase inhibitor
has_related_synonym: aconitate hydratase inhibitors
has_related_synonym: cis-aconitase inhibitor
has_related_synonym: cis-aconitase inhibitors
has_related_synonym: citrate hydro-lyase inhibitor
has_related_synonym: citrate hydro-lyase inhibitors
has_related_synonym: citrate(isocitrate) hydro-lyase (cis-aconitate-forming) inhibitor
has_related_synonym: citrate(isocitrate) hydro-lyase (cis-aconitate-forming) inhibitors
has_related_synonym: citrate(isocitrate) hydro-lyase inhibitor
has_related_synonym: citrate(isocitrate) hydro-lyase inhibitors
id: CHEBI:62608
in subset: 3 STAR

EC 3.11.1.3 (phosphonopyruvate hydrolase) inhibitor
type: Class
subclass of: EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitor
textual definition: An EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitor that interferes with the action of phosphonopyruvate hydrolase (EC 3.11.1.3).
imported from: chebi.owl
has cross-reference: Wikipedia:Phosphonopyruvate_hydrolase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.11.1.3 (phosphonopyruvate hydrolase) inhibitors
has_related_synonym: EC 3.11.1.3 inhibitor
has_related_synonym: EC 3.11.1.3 inhibitors
has_related_synonym: PPH inhibitor
has_related_synonym: PPH inhibitors
has_related_synonym: phosphonopyruvate hydrolase (EC 3.11.1.3) inhibitor
has_related_synonym: phosphonopyruvate hydrolase (EC 3.11.1.3) inhibitors
has_related_synonym: phosphonopyruvate hydrolase inhibitor
has_related_synonym: phosphonopyruvate hydrolase inhibitors
id: CHEBI:62609
in subset: 3 STAR

glycine receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that blocks glycine receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glycine receptor antagonists
id: CHEBI:62754
in subset: 3 STAR

fuel additive
type: Class
subclass of: chemical role
textual definition: Any additive that enhances the efficiency of fuel.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fuel additives
has_related_synonym: fuel enhancer
id: CHEBI:62803
in subset: 3 STAR

hepatoprotective agent
type: Class
subclass of: protective agent
textual definition: Any compound that is able to prevent damage to the liver.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antihepatotoxic agent
has_related_synonym: hepatoprotective agents
has_related_synonym: hepatoprotector
id: CHEBI:62868
in subset: 3 STAR

EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor
type: Class
subclass of: EC 4.3.1.* (ammonia-lyase) inhibitor
textual definition: An EC 4.3.* (C-N lyase) inhibitor that interferes with the action of phenylalanine ammonia-lyase (EC 4.3.1.24).
imported from: chebi.owl
has cross-reference: Wikipedia:Phenylalanine_ammonia-lyase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitors
has_related_synonym: EC 4.3.1.24 inhibitor
has_related_synonym: EC 4.3.1.24 inhibitors
has_related_synonym: L-phenylalanine ammonia-lyase (trans-cinnamate-forming) inhibitor
has_related_synonym: L-phenylalanine ammonia-lyase (trans-cinnamate-forming) inhibitors
has_related_synonym: L-phenylalanine ammonia-lyase inhibitor
has_related_synonym: L-phenylalanine ammonia-lyase inhibitors
has_related_synonym: PAL inhibitor
has_related_synonym: PAL inhibitors
has_related_synonym: Phe ammonia-lyase inhibitor
has_related_synonym: Phe ammonia-lyase inhibitors
has_related_synonym: phenylalanine ammonia-lyase (EC 4.3.1.24) inhibitor
has_related_synonym: phenylalanine ammonia-lyase (EC 4.3.1.24) inhibitors
has_related_synonym: phenylalanine ammonia-lyase inhibitor
has_related_synonym: phenylalanine ammonia-lyase inhibitors
has_related_synonym: phenylalanine ammonium-lyase inhibitor
has_related_synonym: phenylalanine ammonium-lyase inhibitors
has_related_synonym: phenylalanine deaminase inhibitor
has_related_synonym: phenylalanine deaminase inhibitors
id: CHEBI:62871
in subset: 3 STAR

EC 1.2.3.1 (aldehyde oxidase) inhibitor
type: Class
subclass of: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor
textual definition: An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Aldehyde_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.2.3.1 (aldehyde oxidase) inhibitors
has_related_synonym: EC 1.2.3.1 inhibitor
has_related_synonym: EC 1.2.3.1 inhibitors
has_related_synonym: aldehyde oxidase (EC 1.2.3.1) inhibitor
has_related_synonym: aldehyde oxidase (EC 1.2.3.1) inhibitors
has_related_synonym: aldehyde oxidase inhibitor
has_related_synonym: aldehyde oxidase inhibitors
has_related_synonym: aldehyde:oxygen oxidoreductase inhibitor
has_related_synonym: aldehyde:oxygen oxidoreductase inhibitors
has_related_synonym: quinoline oxidase inhibitor
has_related_synonym: quinoline oxidase inhibitors
has_related_synonym: retinal oxidase inhibitor
has_related_synonym: retinal oxidase inhibitors
has_related_synonym: retinoic acid synthase inhibitor
has_related_synonym: retinoic acid synthase inhibitors
id: CHEBI:62872
in subset: 3 STAR

odorant receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates an odorant receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:62873
in subset: 3 STAR

tankyrase inhibitor
type: Class
subclass of: EC 2.4.* (glycosyltransferase) inhibitor
textual definition: Any compound that inhibits the action of tankyrase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: tankyrase inhibitors
id: CHEBI:62887
in subset: 3 STAR

EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.2.* (pentosyltransferase) inhibitor
textual definition: An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD(+) ADP-ribosyltransferase (EC 2.4.2.30).
imported from: chebi.owl
has cross-reference: Wikipedia:PARP_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: ADP-ribosyltransferase (polymerising) inhibitor
has_related_synonym: ADP-ribosyltransferase (polymerising) inhibitors
has_related_synonym: ADP-ribosyltransferase (polymerizing) inhibitor
has_related_synonym: ADP-ribosyltransferase (polymerizing) inhibitors
has_related_synonym: EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitors
has_related_synonym: EC 2.4.2.30 inhibitor
has_related_synonym: EC 2.4.2.30 inhibitors
has_related_synonym: NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitor
has_related_synonym: NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitors
has_related_synonym: NAD(+) ADP-ribosyltransferase inhibitor
has_related_synonym: NAD(+) ADP-ribosyltransferase inhibitors
has_related_synonym: NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor
has_related_synonym: NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors
has_related_synonym: NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor
has_related_synonym: NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors
has_related_synonym: PARP
has_related_synonym: PARPs
has_related_synonym: poly(ADP-ribose) polymerase inhibitor
has_related_synonym: poly(ADP-ribose) polymerase inhibitors
has_related_synonym: poly(ADP-ribose) synthase inhibitor
has_related_synonym: poly(ADP-ribose) synthase inhibitors
has_related_synonym: poly(ADP-ribose) synthetase inhibitor
has_related_synonym: poly(ADP-ribose) synthetase inhibitors
has_related_synonym: poly(adenosine diphosphate ribose) polymerase inhibitor
has_related_synonym: poly(adenosine diphosphate ribose) polymerase inhibitors
id: CHEBI:62913
in subset: 3 STAR

axin stabilizer
type: Class
subclass of: biochemical role
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:62914
in subset: 1 STAR

sialyltransferase inhibitor
type: Class
subclass of: EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitor
textual definition: An EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitor that interferes with the action of a sialyltransferase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sialyltransferase inhibitors
id: CHEBI:62915
in subset: 3 STAR

emulsifier
type: Class
subclass of: chemical role
textual definition: The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: emulgent
has_related_synonym: emulgents
has_related_synonym: emulsifiers
id: CHEBI:63046
in subset: 3 STAR

food emulsifier
type: Class
subclass of: emulsifier
subclass of: food additive
textual definition: A food additive used to form or maintain a uniform emulsion of two (or more) phases in a food.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food emulsifiers
id: CHEBI:63047
in subset: 3 STAR

osteogenesis regulator
type: Class
subclass of: growth regulator
textual definition: Any compound that induces or regulates osteogenesis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: osteogenesis regulators
id: CHEBI:63054
in subset: 3 STAR

phase-transfer catalyst
type: Class
subclass of: catalyst
textual definition: A catalyst that facilitates the migration of a reactant from one phase into another phase where reaction occurs.
imported from: chebi.owl
has cross-reference: Wikipedia:Phase_transfer_catalyst
has_obo_namespace: chebi_ontology
has_related_synonym: PTC
has_related_synonym: phase transfer catalyst
has_related_synonym: phase transfer catalysts
has_related_synonym: phase-transfer catalysts
id: CHEBI:63060
in subset: 3 STAR

crystallisation adjutant
type: Class
subclass of: chemical role
textual definition: Chemical role played by a material when used to promote crystallisation.
imported from: chebi.owl
has cross-reference: Wikipedia:Crystallization_adjutant
has_obo_namespace: chebi_ontology
has_related_synonym: crystallisation adjutants
has_related_synonym: crystallization adjutant
has_related_synonym: crystallization adjutants
id: CHEBI:63064
in subset: 3 STAR

EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
type: Class
subclass of: EC 2.4.2.* (pentosyltransferase) inhibitor
textual definition: An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of purine nucleoside phosphorylase (EC 2.4.2.1).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitors
has_related_synonym: EC 2.4.2.1 inhibitor
has_related_synonym: EC 2.4.2.1 inhibitors
has_related_synonym: PNPase inhibitor
has_related_synonym: PNPase inhibitors
has_related_synonym: PUNPI inhibitor
has_related_synonym: PUNPI inhibitors
has_related_synonym: PUNPII inhibitor
has_related_synonym: PUNPII inhibitors
has_related_synonym: inosine phosphorylase inhibitor
has_related_synonym: inosine phosphorylase inhibitors
has_related_synonym: inosine-guanosine phosphorylase inhibitor
has_related_synonym: inosine-guanosine phosphorylase inhibitors
has_related_synonym: nucleotide phosphatase inhibitor
has_related_synonym: nucleotide phosphatase inhibitors
has_related_synonym: purine deoxynucleoside phosphorylase inhibitor
has_related_synonym: purine deoxynucleoside phosphorylase inhibitors
has_related_synonym: purine deoxyribonucleoside phosphorylase inhibitor
has_related_synonym: purine deoxyribonucleoside phosphorylase inhibitors
has_related_synonym: purine nucleoside phosphorylase inhibitor
has_related_synonym: purine nucleoside phosphorylase inhibitors
has_related_synonym: purine ribonucleoside phosphorylase inhibitor
has_related_synonym: purine ribonucleoside phosphorylase inhibitors
has_related_synonym: purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitor
has_related_synonym: purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitors
has_related_synonym: purine-nucleoside phosphorylase inhibitor
has_related_synonym: purine-nucleoside phosphorylase inhibitors
has_related_synonym: purine-nucleoside:phosphate ribosyltransferase inhibitor
has_related_synonym: purine-nucleoside:phosphate ribosyltransferase inhibitors
id: CHEBI:63090
in subset: 3 STAR

sphingosine-1-phosphate receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates sphingosine 1-phosphate receptors.
imported from: chebi.owl
has_alternative_id: CHEBI:63172
has_obo_namespace: chebi_ontology
has_related_synonym: EDG receptor agonist
has_related_synonym: S1P receptor agonist
has_related_synonym: S1P receptor agonists
has_related_synonym: SIP agonist
has_related_synonym: SIP agonists
has_related_synonym: sphingosine 1-phosphate receptor agonist
has_related_synonym: sphingosine 1-phosphate receptor agonists
has_related_synonym: sphingosine-1-phosphate receptor agonists
id: CHEBI:63114
in subset: 3 STAR

insulin release inhibitor
type: Class
subclass of: inhibitor
textual definition: Any substance that inhibits the release of insulin
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:63146
in subset: 3 STAR

EC 1.1.3.13 (alcohol oxidase) inhibitor
type: Class
subclass of: EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor
textual definition: An EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor that interferes with the action of alcohol oxidase (EC 1.1.3.13).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.3.13 (alcohol oxidase) inhibitors
has_related_synonym: EC 1.1.3.13 inhibitor
has_related_synonym: EC 1.1.3.13 inhibitors
has_related_synonym: alcohol oxidase (EC 1.1.3.13) inhibitor
has_related_synonym: alcohol oxidase (EC 1.1.3.13) inhibitors
has_related_synonym: alcohol oxidase inhibitor
has_related_synonym: alcohol oxidase inhibitors
has_related_synonym: alcohol:oxygen oxidoreductase inhibitor
has_related_synonym: alcohol:oxygen oxidoreductase inhibitors
has_related_synonym: ethanol oxidase inhibitor
has_related_synonym: ethanol oxidase inhibitors
id: CHEBI:63156
in subset: 3 STAR

EC 4.2.1.22 (cystathionine beta-synthase) inhibitor
type: Class
subclass of: EC 4.2.1.* (hydro-lyases) inhibitor
textual definition: An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of cystathionine beta-synthase (EC 4.2.1.22).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.2.1.22 (cystathionine beta-synthase) inhibitors
has_related_synonym: EC 4.2.1.22 inhibitor
has_related_synonym: EC 4.2.1.22 inhibitors
has_related_synonym: L-serine hydro-lyase (adding homocysteine) inhibitor
has_related_synonym: L-serine hydro-lyase (adding homocysteine) inhibitors
has_related_synonym: L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) inhibitor
has_related_synonym: L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) inhibitors
has_related_synonym: beta-thionase inhibitor
has_related_synonym: beta-thionase inhibitors
has_related_synonym: cystathionine beta-synthase (EC 4.2.1.22) inhibitor
has_related_synonym: cystathionine beta-synthase (EC 4.2.1.22) inhibitors
has_related_synonym: cystathionine beta-synthase inhibitor
has_related_synonym: cystathionine beta-synthase inhibitors
has_related_synonym: cystathionine-beta-synthase inhibitor
has_related_synonym: cystathionine-beta-synthase inhibitors
has_related_synonym: cysteine synthase inhibitor
has_related_synonym: cysteine synthase inhibitors
has_related_synonym: methylcysteine synthase inhibitor
has_related_synonym: methylcysteine synthase inhibitors
has_related_synonym: serine sulfhydrase inhibitor
has_related_synonym: serine sulfhydrase inhibitors
has_related_synonym: serine sulfhydrylase inhibitor
has_related_synonym: serine sulfhydrylase inhibitors
id: CHEBI:63157
in subset: 3 STAR

EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of mitochondrial carnitine O-palmitoyltransferase (EC 2.3.1.21).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CPT I (outer membrane carnitine palmitoyl transferase) inhibitor
has_related_synonym: CPT I (outer membrane carnitine palmitoyl transferase) inhibitors
has_related_synonym: CPT inhibitor
has_related_synonym: CPT inhibitors
has_related_synonym: CPT-A inhibitor
has_related_synonym: CPT-A inhibitors
has_related_synonym: CPT-B inhibitor
has_related_synonym: CPT-B inhibitors
has_related_synonym: CPTi inhibitor
has_related_synonym: CPTi inhibitors
has_related_synonym: CPTo inhibitor
has_related_synonym: CPTo inhibitors
has_related_synonym: CTP-1 inhibitor
has_related_synonym: CTP-1 inhibitors
has_related_synonym: EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitors
has_related_synonym: EC 2.3.1.21 inhibitor
has_related_synonym: EC 2.3.1.21 inhibitors
has_related_synonym: L-carnitine palmitoyltransferase inhibitor
has_related_synonym: L-carnitine palmitoyltransferase inhibitors
has_related_synonym: acylcarnitine transferase inhibitor
has_related_synonym: acylcarnitine transferase inhibitors
has_related_synonym: carnitine O-palmitoyltransferase (EC 2.3.1.21) inhibitor
has_related_synonym: carnitine O-palmitoyltransferase (EC 2.3.1.21) inhibitors
has_related_synonym: carnitine O-palmitoyltransferase inhibitor
has_related_synonym: carnitine O-palmitoyltransferase inhibitors
has_related_synonym: carnitine palmitoyltransferase II inhibitor
has_related_synonym: carnitine palmitoyltransferase II inhibitors
has_related_synonym: carnitine palmitoyltransferase inhibitor
has_related_synonym: carnitine palmitoyltransferase inhibitors
has_related_synonym: carnitine palmitoyltransferase-1 inhibitor
has_related_synonym: carnitine palmitoyltransferase-1 inhibitors
has_related_synonym: carnitine palmitoyltransferase-A inhibitor
has_related_synonym: carnitine palmitoyltransferase-A inhibitors
has_related_synonym: mitochondrial carnitine palmitoyltransferase-1 inhibitor
has_related_synonym: mitochondrial carnitine palmitoyltransferase-1 inhibitors
has_related_synonym: outer malonyl-CoA inhibitable carnitine palmitoyltransferase inhibitor
has_related_synonym: outer malonyl-CoA inhibitable carnitine palmitoyltransferase inhibitors
has_related_synonym: palmitoyl-CoA:L-carnitine O-palmitoyltransferase inhibitor
has_related_synonym: palmitoyl-CoA:L-carnitine O-palmitoyltransferase inhibitors
has_related_synonym: palmitoylcarnitine transferase inhibitor
has_related_synonym: palmitoylcarnitine transferase inhibitors
id: CHEBI:63158
in subset: 3 STAR

T-cell proliferation inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor that interferes with the process of T-cell proliferation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: T-cell proliferation inhibitors
id: CHEBI:63173
in subset: 3 STAR

peptidomimetic
type: Class
subclass of: biochemical role
textual definition: A small protein-like chain designed to mimic a peptide.
imported from: chebi.owl
has cross-reference: Wikipedia:Peptidomimetic
has_obo_namespace: chebi_ontology
has_related_synonym: peptidomimetics
id: CHEBI:63175
in subset: 3 STAR

reducing agent
type: Class
subclass of: chemical role
textual definition: The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species.
imported from: chebi.owl
has cross-reference: Wikipedia:Reducing_agent
has_obo_namespace: chebi_ontology
has_related_synonym: reducer
has_related_synonym: reducers
has_related_synonym: reducing agents
has_related_synonym: reductant
has_related_synonym: reductants
id: CHEBI:63247
in subset: 3 STAR

oxidising agent
type: Class
subclass of: chemical role
textual definition: A substance that removes electrons from another reactant in a redox reaction.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: oxidant
has_related_synonym: oxidants
has_related_synonym: oxidiser
has_related_synonym: oxidisers
has_related_synonym: oxidising agents
has_related_synonym: oxidizer
has_related_synonym: oxidizers
has_related_synonym: oxidizing agent
has_related_synonym: oxidizing agents
id: CHEBI:63248
in subset: 3 STAR

sodium-dependent Pi-transporter inhibitor
type: Class
subclass of: inhibitor
textual definition: Any substance that inhibits the action of sodium-dependent Pi-transporters.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NPC inhibitor
has_related_synonym: Na-Pi inhibitor
has_related_synonym: sodium-dependent inorganic phosphate cotransporter inhibitor
has_related_synonym: sodium-dependent inorganic phosphate transporter inhibitor
id: CHEBI:63330
in subset: 3 STAR

EC 3.1.3.1 (alkaline phosphatase) inhibitor
type: Class
subclass of: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
textual definition: An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of alkaline phosphatase (EC 3.1.3.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Alkaline_phosphatase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.3.1 (alkaline phosphatase) inhibitors
has_related_synonym: EC 3.1.3.1 inhibitor
has_related_synonym: EC 3.1.3.1 inhibitors
has_related_synonym: alkaline phenyl phosphatase inhibitor
has_related_synonym: alkaline phenyl phosphatase inhibitors
has_related_synonym: alkaline phosphatase (EC 3.1.3.1) inhibitor
has_related_synonym: alkaline phosphatase (EC 3.1.3.1) inhibitors
has_related_synonym: alkaline phosphatase inhibitor
has_related_synonym: alkaline phosphatase inhibitors
has_related_synonym: alkaline phosphohydrolase inhibitor
has_related_synonym: alkaline phosphohydrolase inhibitors
has_related_synonym: alkaline phosphomonoesterase inhibitor
has_related_synonym: alkaline phosphomonoesterase inhibitors
has_related_synonym: glycerophosphatase inhibitor
has_related_synonym: glycerophosphatase inhibitors
has_related_synonym: orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitor
has_related_synonym: orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitors
has_related_synonym: phosphate-monoester phosphohydrolase (alkaline optimum) inhibitor
has_related_synonym: phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors
has_related_synonym: phosphomonoesterase inhibitor
has_related_synonym: phosphomonoesterase inhibitors
id: CHEBI:63332
in subset: 3 STAR

fibroblast growth factor receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the fibroblast growth factor receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: FGFR inhibitor
has_related_synonym: FGFR inhibitors
has_related_synonym: fibroblast growth factor receptor antagonists
has_related_synonym: fibroblast growth factor receptor inhibitor
has_related_synonym: fibroblast growth factor receptor inhibitors
id: CHEBI:63457
in subset: 3 STAR

explosive
type: Class
subclass of: chemical role
textual definition: A substance capable of undergoing rapid and highly exothermic decomposition.
imported from: chebi.owl
has cross-reference: Wikipedia:Explosive_material
has_obo_namespace: chebi_ontology
has_related_synonym: explosive compound
has_related_synonym: explosive compounds
has_related_synonym: explosive material
has_related_synonym: explosives
has_related_synonym: explosives chemical
has_related_synonym: explosives chemicals
id: CHEBI:63490
in subset: 3 STAR

EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
textual definition: An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of Na(+)/K(+)-transporting ATPase (EC 3.6.3.9).
imported from: chebi.owl
has cross-reference: Wikipedia:Sodium-potassium_ATPase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitors
has_related_synonym: EC 3.6.3.9 inhibitor
has_related_synonym: EC 3.6.3.9 inhibitors
has_related_synonym: Na(+)/K(+)-ATPase inhibitor
has_related_synonym: Na(+)/K(+)-ATPase inhibitors
has_related_synonym: Na(+)/K(+)-pump inhibitor
has_related_synonym: Na(+)/K(+)-pump inhibitors
has_related_synonym: Na(+)/K(+)-transporting ATPase (EC 3.6.3.9) inhibitor
has_related_synonym: Na(+)/K(+)-transporting ATPase (EC 3.6.3.9) inhibitors
has_related_synonym: Na(+)/K(+)-transporting ATPase inhibitor
has_related_synonym: Na(+)/K(+)-transporting ATPase inhibitors
has_related_synonym: sodium pump inhibitor
has_related_synonym: sodium pump inhibitors
has_related_synonym: sodium-potassium adenosine triphosphatase inhibitor
has_related_synonym: sodium-potassium adenosine triphosphatase inhibitors
has_related_synonym: sodium-potassium pump inhibitor
has_related_synonym: sodium-potassium pump inhibitors
id: CHEBI:63510
in subset: 3 STAR

gonadotropin releasing hormone agonist
type: Class
subclass of: hormone agonist
textual definition: Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response.
imported from: chebi.owl
has cross-reference: Wikipedia:Gonadotropin-releasing_hormone_agonist
has_obo_namespace: chebi_ontology
has_related_synonym: GnRH agonist
has_related_synonym: GnRH agonists
has_related_synonym: GnRH-A
has_related_synonym: gonadotrophin releasing hormone agonist
has_related_synonym: gonadotrophin releasing hormone agonists
has_related_synonym: gonadotropin releasing hormone agonists
id: CHEBI:63533
in subset: 3 STAR

glucocorticoid receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates a glucocorticoid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glucocorticoid receptor agonists
id: CHEBI:63562
in subset: 3 STAR

chemokine receptor 5 antagonist
type: Class
subclass of: antagonist
textual definition: An antogonist that blocks chemokine receptor 5 (CCR5).
imported from: chebi.owl
has cross-reference: Wikipedia:CCR5
has_obo_namespace: chebi_ontology
has_related_synonym: C-C chemokine receptor 5 antagonist
has_related_synonym: C-C chemokine receptor 5 antagonists
has_related_synonym: CCR-5 antagonist
has_related_synonym: CCR-5 antagonists
has_related_synonym: CCR5 antagonist
has_related_synonym: CCR5 antagonists
has_related_synonym: chemokine receptor 5 antagonists
id: CHEBI:63673
in subset: 3 STAR

EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor
type: Class
subclass of: EC 2.6.1.* (transaminase) inhibitor
textual definition: An EC 2.6.1.* (transaminase) inhibitor that interferes with the action of 4-aminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.19).
imported from: chebi.owl
has cross-reference: Wikipedia:4-aminobutyrate_transaminase
has_obo_namespace: chebi_ontology
has_related_synonym: 4-aminobutanoate:2-oxoglutarate aminotransferase inhibitor
has_related_synonym: 4-aminobutanoate:2-oxoglutarate aminotransferase inhibitors
has_related_synonym: 4-aminobutyrate aminotransferase inhibitor
has_related_synonym: 4-aminobutyrate aminotransferase inhibitors
has_related_synonym: 4-aminobutyrate transaminase inhibitor
has_related_synonym: 4-aminobutyrate transaminase inhibitors
has_related_synonym: 4-aminobutyrate--2-ketoglutarate aminotransferase inhibitor
has_related_synonym: 4-aminobutyrate--2-ketoglutarate aminotransferase inhibitors
has_related_synonym: 4-aminobutyrate--2-oxoglutarate aminotransferase inhibitor
has_related_synonym: 4-aminobutyrate--2-oxoglutarate aminotransferase inhibitors
has_related_synonym: 4-aminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.19) inhibitor
has_related_synonym: 4-aminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.19) inhibitors
has_related_synonym: 4-aminobutyrate--2-oxoglutarate transaminase inhibitor
has_related_synonym: 4-aminobutyrate--2-oxoglutarate transaminase inhibitors
has_related_synonym: 4-aminobutyrate-2-oxoglutarate transaminase inhibitor
has_related_synonym: 4-aminobutyrate-2-oxoglutarate transaminase inhibitors
has_related_synonym: 4-aminobutyric acid 2-ketoglutaric acid aminotransferase inhibitor
has_related_synonym: 4-aminobutyric acid 2-ketoglutaric acid aminotransferase inhibitors
has_related_synonym: 4-aminobutyric acid aminotransferase inhibitor
has_related_synonym: 4-aminobutyric acid aminotransferase inhibitors
has_related_synonym: EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitors
has_related_synonym: EC 2.6.1.19 inhibitor
has_related_synonym: EC 2.6.1.19 inhibitors
has_related_synonym: GABA aminotransferase inhibitor
has_related_synonym: GABA aminotransferase inhibitors
has_related_synonym: GABA transaminase inhibitor
has_related_synonym: GABA transaminase inhibitors
has_related_synonym: GABA transferase inhibitor
has_related_synonym: GABA transferase inhibitors
has_related_synonym: GABA--2-oxoglutarate aminotransferase inhibitor
has_related_synonym: GABA--2-oxoglutarate aminotransferase inhibitors
has_related_synonym: GABA--2-oxoglutarate transaminase inhibitor
has_related_synonym: GABA--2-oxoglutarate transaminase inhibitors
has_related_synonym: GABA--alpha-ketoglutarate aminotransferase inhibitors
has_related_synonym: GABA--alpha-ketoglutarate transaminase inhibitor
has_related_synonym: GABA--alpha-ketoglutarate transaminase inhibitors
has_related_synonym: GABA--alpha-ketoglutaric acid transaminase inhibitor
has_related_synonym: GABA--alpha-ketoglutaric acid transaminase inhibitors
has_related_synonym: GABA--alpha-oxoglutarate aminotransferase inhibitor
has_related_synonym: GABA--alpha-oxoglutarate aminotransferase inhibitors
has_related_synonym: GABA--oxoglutarate aminotransferase inhibitor
has_related_synonym: GABA--oxoglutarate aminotransferase inhibitors
has_related_synonym: GABA--oxoglutarate transaminase inhibitor
has_related_synonym: GABA--oxoglutarate transaminase inhibitors
has_related_synonym: GabT inhibitor
has_related_synonym: GabT inhibitors
has_related_synonym: aminobutyrate aminotransferase inhibitor
has_related_synonym: aminobutyrate aminotransferase inhibitors
has_related_synonym: aminobutyrate transaminase inhibitor
has_related_synonym: aminobutyrate transaminase inhibitors
has_related_synonym: beta-alanine aminotransferase inhibitor
has_related_synonym: beta-alanine aminotransferase inhibitors
has_related_synonym: beta-alanine--oxoglutarate aminotransferase inhibitor
has_related_synonym: beta-alanine--oxoglutarate aminotransferase inhibitors
has_related_synonym: beta-alanine--oxoglutarate transaminase inhibitor
has_related_synonym: beta-alanine--oxoglutarate transaminase inhibitors
has_related_synonym: gamma-amino-N-butyrate transaminase inhibitor
has_related_synonym: gamma-amino-N-butyrate transaminase inhibitors
has_related_synonym: gamma-aminobutyrate aminotransaminase inhibitor
has_related_synonym: gamma-aminobutyrate aminotransaminase inhibitors
has_related_synonym: gamma-aminobutyrate transaminase inhibitor
has_related_synonym: gamma-aminobutyrate transaminase inhibitors
has_related_synonym: gamma-aminobutyrate--alpha-ketoglutarate aminotransferase inhibitor
has_related_synonym: gamma-aminobutyrate--alpha-ketoglutarate aminotransferase inhibitors
has_related_synonym: gamma-aminobutyrate--alpha-ketoglutarate transaminase inhibitor
has_related_synonym: gamma-aminobutyrate--alpha-ketoglutarate transaminase inhibitors
has_related_synonym: gamma-aminobutyrate:alpha-oxoglutarate aminotransferase inhibitor
has_related_synonym: gamma-aminobutyrate:alpha-oxoglutarate aminotransferase inhibitors
has_related_synonym: gamma-aminobutyric acid aminotransferase inhibitor
has_related_synonym: gamma-aminobutyric acid aminotransferase inhibitors
has_related_synonym: gamma-aminobutyric acid pyruvate transaminase inhibitor
has_related_synonym: gamma-aminobutyric acid pyruvate transaminase inhibitors
has_related_synonym: gamma-aminobutyric acid transaminase inhibitor
has_related_synonym: gamma-aminobutyric acid transaminase inhibitors

EC 2.1.1.45 (thymidylate synthase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of thymidylate synthase (EC 2.1.1.45).
imported from: chebi.owl
has cross-reference: Wikipedia:Thymidylate_synthase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase inhibitor
has_related_synonym: 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase inhibitors
has_related_synonym: EC 2.1.1.45 (thymidylate synthase) inhibitors
has_related_synonym: EC 2.1.1.45 inhibitor
has_related_synonym: EC 2.1.1.45 inhibitors
has_related_synonym: TMP synthetase inhibitor
has_related_synonym: TMP synthetase inhibitors
has_related_synonym: dTMP synthase inhibitor
has_related_synonym: dTMP synthase inhibitors
has_related_synonym: methylenetetrahydrofolate:dUMP C-methyltransferase inhibitor
has_related_synonym: methylenetetrahydrofolate:dUMP C-methyltransferase inhibitors
has_related_synonym: thymidylate synthase inhibitor
has_related_synonym: thymidylate synthase inhibitors
has_related_synonym: thymidylate synthetase inhibitor
has_related_synonym: thymidylate synthetase inhibitors
id: CHEBI:63720
in subset: 3 STAR

EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
type: Class
subclass of: EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor
textual definition: An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of phosphoribosylglycinamide formyltransferase (EC 2.1.2.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Phosphoribosylglycinamide_formyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase inhibitors
has_related_synonym: 2-amino-N-ribosylacetamide 5'-phosphate transformylase inhibitor
has_related_synonym: 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase inhibitor
has_related_synonym: 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase inhibitors
has_related_synonym: EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitors
has_related_synonym: EC 2.1.2.2 inhibitor
has_related_synonym: EC 2.1.2.2 inhibitors
has_related_synonym: GAR TFase inhibitor
has_related_synonym: GAR TFase inhibitors
has_related_synonym: GAR formyltransferase inhibitor
has_related_synonym: GAR formyltransferase inhibitors
has_related_synonym: GAR transformylase inhibitor
has_related_synonym: GAR transformylase inhibitors
has_related_synonym: glycinamide ribonucleotide formyltransferase inhibitor
has_related_synonym: glycinamide ribonucleotide formyltransferase inhibitors
has_related_synonym: glycinamide ribonucleotide transformylase inhibitor
has_related_synonym: glycinamide ribonucleotide transformylase inhibitors
has_related_synonym: phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) inhibitor
has_related_synonym: phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) inhibitors
has_related_synonym: phosphoribosylglycinamide formyltransferase inhibitor
has_related_synonym: phosphoribosylglycinamide formyltransferase inhibitors
id: CHEBI:63721
in subset: 3 STAR

neuroprotective agent
type: Class
subclass of: protective agent
textual definition: Any compound that can be used for the treatment of neurodegenerative disorders.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: neuroprotectant
has_related_synonym: neuroprotectants
has_related_synonym: neuroprotective agents
id: CHEBI:63726
in subset: 3 STAR

retinoid X receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates a retinoid X receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Retinoid_X_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: retinoid X receptor agonists
id: CHEBI:63794
in subset: 3 STAR

film-forming compound
type: Class
subclass of: chemical role
textual definition: Any compound that leaves a pliable, cohesive, and continuous covering over a surface when applied to it.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: film-forming agent
has_related_synonym: film-forming agents
has_related_synonym: film-forming compounds
id: CHEBI:63908
in subset: 3 STAR

sclerotherapy agent
type: Class
subclass of: biological role
textual definition: A sclerotherapy agent is used to treat blood vessels or blood vessel malformations (vascular malformations) and also those of the lymphatic system by injection into the vessels, which makes them shrink.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sclerotherapy agents
id: CHEBI:63923
in subset: 3 STAR

EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor
textual definition: An EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of tyrosine 3-monooxygenase (EC 1.14.16.2).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitors
has_related_synonym: EC 1.14.16.2 inhibitor
has_related_synonym: EC 1.14.16.2 inhibitors
has_related_synonym: L-tyrosine hydroxylase inhibitor
has_related_synonym: L-tyrosine hydroxylase inhibitors
has_related_synonym: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) inhibitor
has_related_synonym: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) inhibitors
has_related_synonym: tyrosine 3-hydroxylase inhibitor
has_related_synonym: tyrosine 3-hydroxylase inhibitors
has_related_synonym: tyrosine 3-monooxygenase (EC 1.14.16.2) inhibitor
has_related_synonym: tyrosine 3-monooxygenase (EC 1.14.16.2) inhibitors
has_related_synonym: tyrosine 3-monooxygenase inhibitor
has_related_synonym: tyrosine 3-monooxygenase inhibitors
has_related_synonym: tyrosine hydroxylase inhibitor
has_related_synonym: tyrosine hydroxylase inhibitors
id: CHEBI:63932
in subset: 3 STAR

alpha1B-adrenoceptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the alpha1B-adrenoceptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: alpha1B-adrenoceptor antagonists
id: CHEBI:63936
in subset: 3 STAR

estrogen receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist at the estrogen receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: estrogen receptor agonists
id: CHEBI:63951
in subset: 3 STAR

adenosine A1 receptor antagonist
type: Class
subclass of: adenosine receptor antagonist
textual definition: An antagonist at the A1 receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_A1_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine A1 receptor antagonists
id: CHEBI:63957
in subset: 3 STAR

cellulose synthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: An pathway inhibitor that inhibits the synthesis of cellulose.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cellulose biosynthesis inhibitor
has_related_synonym: cellulose biosynthesis inhibitors
has_related_synonym: cellulose synthesis inhibitors
id: CHEBI:63958
in subset: 3 STAR

Hsp90 inhibitor
type: Class
subclass of: EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor
textual definition: An EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor that blocks the action of heat shock protein 90.
imported from: chebi.owl
has cross-reference: PMID:19860732
has cross-reference: PMID:19946660
has cross-reference: PMID:22035754
has cross-reference: PMID:22920907
has cross-reference: PMID:22959035
has cross-reference: PMID:23160336
has cross-reference: PMID:23312026
has cross-reference: Wikipedia:Hsp90_inhibitors
has_obo_namespace: chebi_ontology
has_related_synonym: Hsp90 inhibitors
has_related_synonym: heat shock protein 90 inhibitor
has_related_synonym: heat shock protein 90 inhibitors
id: CHEBI:63962
in subset: 3 STAR

metabotropic glutamate receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the metabotropic glutamate receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: mGluR antagonist
has_related_synonym: mGluR antagonists
has_related_synonym: metabotropic glutamate receptor antagonists
id: CHEBI:63963
in subset: 3 STAR

protein kinase C agonist
type: Class
subclass of: protein kinase agonist
textual definition: An agonist that selectively binds to and activates a protein kinase C receptor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: protein kinase C agonists
id: CHEBI:64018
in subset: 3 STAR

EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of fatty acid amide hydrolase (EC 3.5.1.99).
imported from: chebi.owl
has cross-reference: PMID:8083191
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.99 (fatty acid amide hydrolase) inhibitors
has_related_synonym: EC 3.5.1.99 inhibitor
has_related_synonym: EC 3.5.1.99 inhibitors
has_related_synonym: FAAH inhibitor
has_related_synonym: FAAH inhibitors
has_related_synonym: anandamide amidohydrolase inhibitor
has_related_synonym: anandamide amidohydrolase inhibitors
has_related_synonym: arachidonoylethanolamide amidohydrolase inhibitor
has_related_synonym: arachidonoylethanolamide amidohydrolase inhibitors
has_related_synonym: fatty acid amide hydrolase (EC 3.5.1.99) inhibitor
has_related_synonym: fatty acid amide hydrolase (EC 3.5.1.99) inhibitors
has_related_synonym: fatty acid amide hydrolase inhibitor
has_related_synonym: fatty acid amide hydrolase inhibitors
has_related_synonym: fatty acylamide amidohydrolase inhibitor
has_related_synonym: fatty acylamide amidohydrolase inhibitors
has_related_synonym: oleamide hydrolase inhibitor
has_related_synonym: oleamide hydrolase inhibitors
id: CHEBI:64033
in subset: 3 STAR

food additive
type: Class
subclass of: application
subclass of: food component
textual definition: Any substance which is added to food to preserve or enhance its flavour and/or appearance.
imported from: chebi.owl
has cross-reference: Wikipedia:Food_additive
has_obo_namespace: chebi_ontology
has_related_synonym: food additives
id: CHEBI:64047
in subset: 3 STAR

food acidity regulator
type: Class
subclass of: food additive
textual definition: A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents.
imported from: chebi.owl
has cross-reference: Wikipedia:Acidity_regulator
has_obo_namespace: chebi_ontology
has_related_synonym: acidity regulator
has_related_synonym: acidity regulators
has_related_synonym: food acidity regulators
has_related_synonym: pH control agent
has_related_synonym: pH control agents
id: CHEBI:64049
in subset: 3 STAR

delta-opioid receptor agonist
type: Class
subclass of: delta-opioid agent
subclass of: opioid receptor agonist
textual definition: A compound that exhibits agonist activity at the delta-opioid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:64054
in subset: 3 STAR

incretin mimetic
type: Class
subclass of: biological role
textual definition: Any compound that mimics the action of incretins, gastrointestinal hormones that cause an increase in the amount of insulin released from the beta cells of the islets of Langerhans after eating, even before blood glucose levels become elevated.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: incretin mimetics
id: CHEBI:64088
in subset: 3 STAR

AMPA receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates AMPA receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:AMPA_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: AMPA receptor agonists
has_related_synonym: AMPAR agonist
has_related_synonym: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor agonist
has_related_synonym: quisqualate receptor agonist
id: CHEBI:64102
in subset: 3 STAR

protein kinase G agonist
type: Class
subclass of: protein kinase agonist
textual definition: An agonist that selectively binds to and activates a protein kinase G receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: protein kinase G agonists
id: CHEBI:64105
in subset: 3 STAR

protein kinase agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates a protein kinase receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: protein kinase agonists
id: CHEBI:64106
in subset: 3 STAR

EC 2.5.1.58 (protein farnesyltransferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein farnesyltransferase (EC 2.5.1.58), one of the three enzymes in the prenyltransferase group.
imported from: chebi.owl
has cross-reference: Wikipedia:Farnesyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.1.58 (protein farnesyltransferase) inhibitors
has_related_synonym: EC 2.5.1.58 inhibitor
has_related_synonym: EC 2.5.1.58 inhibitors
has_related_synonym: FTase inhibitor
has_related_synonym: FTase inhibitors
has_related_synonym: farnesyl transferase inhibitor
has_related_synonym: farnesyl transferase inhibitors
has_related_synonym: farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitor
has_related_synonym: farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitors
has_related_synonym: farnesyltransferase inhibitor
has_related_synonym: farnesyltransferase inhibitors
has_related_synonym: protein farnesyltransferase (EC 2.5.1.58) inhibitor
has_related_synonym: protein farnesyltransferase (EC 2.5.1.58) inhibitors
has_related_synonym: protein farnesyltransferase inhibitor
has_related_synonym: protein farnesyltransferase inhibitors
id: CHEBI:64133
in subset: 3 STAR

cysteine protease inhibitor
type: Class
subclass of: protease inhibitor
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: Any protease inhibitor that restricts the action of a cysteine protease.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cysteine protease inhibitors
has_related_synonym: cysteine proteinase inhibitor
has_related_synonym: cysteine proteinase inhibitors
id: CHEBI:64152
in subset: 3 STAR

H3-receptor agonist
type: Class
subclass of: histamine agonist
textual definition: A histamine agonist that binds to and activates histamine H3-receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: H3-receptor agonists
has_related_synonym: histamine H3-receptor agonist
has_related_synonym: histamine H3-receptor agonists
id: CHEBI:64154
in subset: 3 STAR

H4-receptor agonist
type: Class
subclass of: histamine agonist
textual definition: A histamine agonist that binds to and activates H4-receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: H4-receptor agonists
id: CHEBI:64155
in subset: 3 STAR

H3-receptor antagonist
type: Class
subclass of: histamine antagonist
textual definition: A histamine antagonist that selectively binds to but does not activate histamine H3 receptors, thereby blocking the actions of endogenous histamine.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: H3-receptor antagonists
has_related_synonym: histamine H3-receptor antagonist
has_related_synonym: histamine H3-receptor antagonists
id: CHEBI:64176
in subset: 3 STAR

EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor
type: Class
subclass of: EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor
textual definition: An EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor that interferes with the action of any UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15), preventing formation of N-acetylglucosamine lipid intermediates and glycosylation of newly synthesised glycoproteins.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitors
has_related_synonym: EC 2.7.8.15 inhibitor
has_related_synonym: EC 2.7.8.15 inhibitors
has_related_synonym: GlcNAc-1-P transferase inhibitor
has_related_synonym: GlcNAc-1-P transferase inhibitors
has_related_synonym: N-acetylglucosamine phosphotransferase inhibitor
has_related_synonym: N-acetylglucosamine transferase inhibitors
has_related_synonym: N-acetylglucosamine-1-phosphate transferase inhibitor
has_related_synonym: N-acetylglucosamine-1-phosphate transferase inhibitors
has_related_synonym: UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitor
has_related_synonym: UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitors
has_related_synonym: UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitor
has_related_synonym: UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitors
has_related_synonym: UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitor
has_related_synonym: UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitors
has_related_synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitor
has_related_synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitors
has_related_synonym: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitor
has_related_synonym: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitors
has_related_synonym: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitor
has_related_synonym: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitors
has_related_synonym: UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitor
has_related_synonym: UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitors
has_related_synonym: UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitor
has_related_synonym: UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitors
has_related_synonym: chitobiosylpyrophosphoryldolichol synthase inhibitor
has_related_synonym: chitobiosylpyrophosphoryldolichol synthase inhibitors
has_related_synonym: dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitor
has_related_synonym: dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitors
has_related_synonym: uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitor
has_related_synonym: uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitors
id: CHEBI:64237
in subset: 3 STAR

reaction intermediate
type: Class
subclass of: chemical role
textual definition: Any chemical substance produced during the conversion of a reactant to a product.
imported from: chebi.owl
has cross-reference: Wikipedia:Reaction_intermediate
has_obo_namespace: chebi_ontology
has_related_synonym: chemical intermediate
id: CHEBI:64297
in subset: 3 STAR

K-ATP channel agonist
type: Class
subclass of: agonist
textual definition: A compound which acts as an agonist at the ATP-sensitive K+ channel.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ATP-sensitive K(+) channel agonist
has_related_synonym: ATP-sensitive K(+) channel agonists
has_related_synonym: ATP-sensitive K+ channel agonist
has_related_synonym: ATP-sensitive K+ channel agonists
has_related_synonym: ATP-sensitive K+ channel opener
has_related_synonym: ATP-sensitive K+ channel openers
has_related_synonym: K(ATP) channel agonist
has_related_synonym: K(ATP) channel agonists
has_related_synonym: K-ATP channel agonists
id: CHEBI:64338
in subset: 3 STAR

MALDI matrix material
type: Class
subclass of: application
textual definition: A compound used to form the matrix for MALDI (matrix-assisted laser desorption/ionization) mass spectrometry. MALDI matrix materials are crystalline compounds with a fairly low molecular weight, so as to allow facile vaporization, have strong absorption at UV or IR wavelengths (to rapidly and efficiently absorb laser irradiation), generally contain polar groups (enabling them to be used in aqueous solutions) and are frequently acidic (so assisting ionisation of the compound being studied, which is contained within the matrix material).
imported from: chebi.owl
has cross-reference: PMID:15373456
has cross-reference: Patent:EP2060919
has cross-reference: Wikipedia:Matrix-assisted_laser_desorption/ionization#Matrix
has_obo_namespace: chebi_ontology
has_related_synonym: 'matrix-assisted laser desorption/ionization' matrix material
has_related_synonym: 'matrix-assisted laser desorption/ionization' matrix materials
has_related_synonym: MALDI matrix materials
has_related_synonym: MALDI matrix solution
has_related_synonym: MALDI matrix solutions
id: CHEBI:64345
in subset: 3 STAR

glutamate transporter activator
type: Class
subclass of: neurotransmitter transporter modulator
textual definition: A neurotransmitter transporter modulator that activates glutamate transporters.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: excitatory amino-acid transporter activator
has_related_synonym: excitatory amino-acid transporter activators
has_related_synonym: glutamate transporter activators
id: CHEBI:64370
in subset: 3 STAR

neurotransmitter transporter modulator
type: Class
subclass of: neurotransmitter agent
subclass of: membrane transport modulator
textual definition: A membrane transport modulator that affects the transport of neurotransmitters.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: neurotransmitter transporter modulators
id: CHEBI:64371
in subset: 3 STAR

EC 3.4.22.38 (cathepsin K) inhibitor
type: Class
subclass of: cysteine protease inhibitor
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: A cysteine protease inhibitor which inhibits cathepsin K (EC 3.4.22.38).
imported from: chebi.owl
has cross-reference: Wikipedia:Cathepsin_K
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.22.38 (cathepsin K) inhibitors
has_related_synonym: EC 3.4.22.38 inhibitor
has_related_synonym: EC 3.4.22.38 inhibitors
has_related_synonym: cathepsin K (EC 3.4.22.38) inhibitor
has_related_synonym: cathepsin K (EC 3.4.22.38) inhibitors
has_related_synonym: cathepsin K inhibitor
has_related_synonym: cathepsin K inhibitors
has_related_synonym: cathepsin O inhibitor
has_related_synonym: cathepsin O inhibitors
has_related_synonym: cathepsin O2 inhibitor
has_related_synonym: cathepsin O2 inhibitors
has_related_synonym: cathepsin X inhibitor
has_related_synonym: cathepsin X inhibitors
id: CHEBI:64406
in subset: 3 STAR

EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of geranylgeranyl diphosphate synthase (EC 2.5.1.29).
imported from: chebi.owl
has cross-reference: Patent:EP1280891
has cross-reference: Patent:US2002004218
has_obo_namespace: chebi_ontology
has_related_synonym: (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase inhibitor
has_related_synonym: (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase inhibitors
has_related_synonym: EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitors
has_related_synonym: EC 2.5.1.29 inhibitor
has_related_synonym: EC 2.5.1.29 inhibitors
has_related_synonym: GGPP synthase inhibitor
has_related_synonym: GGPP synthase inhibitors
has_related_synonym: farnesyltransferase inhibitor
has_related_synonym: farnesyltransferase inhibitors
has_related_synonym: geranylgeranyl diphosphate synthase (EC 2.5.1.29) inhibitor
has_related_synonym: geranylgeranyl diphosphate synthase (EC 2.5.1.29) inhibitors
has_related_synonym: geranylgeranyl diphosphate synthase inhibitor
has_related_synonym: geranylgeranyl diphosphate synthase inhibitors
has_related_synonym: geranylgeranyl pyrophosphate synthase inhibitor
has_related_synonym: geranylgeranyl pyrophosphate synthase inhibitors
has_related_synonym: geranylgeranyl pyrophosphate synthetase inhibitor
has_related_synonym: geranylgeranyl pyrophosphate synthetase inhibitors
has_related_synonym: geranylgeranyl-PP synthetase inhibitor
has_related_synonym: geranylgeranyl-PP synthetase inhibitors
id: CHEBI:64411
in subset: 3 STAR

EC 1.3.1.43 (arogenate dehydrogenase) inhibitor
type: Class
subclass of: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of arogenate dehydrogenase (EC 1.3.1.43).
imported from: chebi.owl
has cross-reference: Wikipedia:Arogenate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.1.43 (arogenate dehydrogenase) inhibitors
has_related_synonym: EC 1.3.1.43 inhibitor
has_related_synonym: EC 1.3.1.43 inhibitors
has_related_synonym: L-arogenate:NAD(+) oxidoreductase (decarboxylating) inhibitor
has_related_synonym: L-arogenate:NAD(+) oxidoreductase (decarboxylating) inhibitors
has_related_synonym: L-arogenate:NAD+ oxidoreductase (decarboxylating) inhibitor
has_related_synonym: L-arogenate:NAD+ oxidoreductase (decarboxylating) inhibitors
has_related_synonym: L-arogenate:NAD+ oxidoreductase inhibitor
has_related_synonym: L-arogenate:NAD+ oxidoreductase inhibitors
has_related_synonym: TyrA(a) inhibitor
has_related_synonym: TyrA(a) inhibitors
has_related_synonym: arogenate dehydrogenase (EC 1.3.1.43) inhibitor
has_related_synonym: arogenate dehydrogenase (EC 1.3.1.43) inhibitors
has_related_synonym: arogenate dehydrogenase inhibitor
has_related_synonym: arogenate dehydrogenase inhibitors
has_related_synonym: cyclohexadienyl dehydrogenase inhibitor
has_related_synonym: cyclohexadienyl dehydrogenase inhibitors
id: CHEBI:64416
in subset: 3 STAR

monolignol
type: Class
subclass of: plant metabolite
textual definition: A metabolite of plant origin (phytochemical) which acts as a source material for biosynthesis of both lignans and lignin.
imported from: chebi.owl
has cross-reference: Wikipedia:Monolignol
has_obo_namespace: chebi_ontology
has_related_synonym: monolignols
id: CHEBI:64477
in subset: 3 STAR

EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor
type: Class
subclass of: EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor
textual definition: An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of glycine hydroxymethyltransferase (EC 2.1.2.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Glycine_hydroxymethyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitor
has_related_synonym: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitors
has_related_synonym: EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitors
has_related_synonym: EC 2.1.2.1 inhibitor
has_related_synonym: EC 2.1.2.1 inhibitors
has_related_synonym: L-serine hydroxymethyltransferase inhibitor
has_related_synonym: L-serine hydroxymethyltransferase inhibitors
has_related_synonym: L-threonine aldolase inhibitor
has_related_synonym: L-threonine aldolase inhibitors
has_related_synonym: allothreonine aldolase inhibitor
has_related_synonym: allothreonine aldolase inhibitors
has_related_synonym: glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitor
has_related_synonym: glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitors
has_related_synonym: glycine hydroxymethyltransferase inhibitor
has_related_synonym: glycine hydroxymethyltransferase inhibitors
has_related_synonym: serine aldolase inhibitor
has_related_synonym: serine aldolase inhibitors
has_related_synonym: serine hydroxymethylase inhibitor
has_related_synonym: serine hydroxymethylase inhibitors
has_related_synonym: serine hydroxymethyltransferase inhibitor
has_related_synonym: serine hydroxymethyltransferase inhibitors
has_related_synonym: serine transhydroxymethylase inhibitor
has_related_synonym: serine transhydroxymethylase inhibitors
has_related_synonym: threonine aldolase inhibitor
has_related_synonym: threonine aldolase inhibitors
id: CHEBI:64570
in subset: 3 STAR

NMDA receptor agonist
type: Class
subclass of: excitatory amino acid agonist
textual definition: An excitatory amino acid agonist which binds to NMDA receptors and triggers a response.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: N-methyl-D-aspartate receptor agonist
has_related_synonym: N-methyl-D-aspartate receptor agonists
has_related_synonym: NMDA receptor agonists
has_related_synonym: NMDAR agonist
has_related_synonym: NMDAR agonists
id: CHEBI:64571
in subset: 3 STAR

flour treatment agent
type: Class
subclass of: food additive
textual definition: A food additive which is added to flour or dough to improve baking quality and/or colour.
imported from: chebi.owl
has cross-reference: Wikipedia:Flour_treatment_agent
alternative_term: flour treatment agent
has_obo_namespace: chebi_ontology
has_related_synonym: dough improver
has_related_synonym: dough improvers
has_related_synonym: improving agent
has_related_synonym: improving agents
id: CHEBI:64577
in subset: 3 STAR

uremic toxin
type: Class
subclass of: toxin
textual definition: A toxin that accumulates in patients with chronic kidney disease.
imported from: chebi.owl
has cross-reference: Wikipedia:Uremic_toxin
has_obo_namespace: chebi_ontology
has_related_synonym: uremic toxins
id: CHEBI:64584
in subset: 3 STAR

glycine transporter 1 inhibitor
type: Class
subclass of: glycine transporter inhibitor
textual definition: Any glycine transporter inhibitor that interferes with the action of glycine 1 transporters.
imported from: chebi.owl
has cross-reference: PMID:17504107
has cross-reference: PMID:18758757
has cross-reference: PMID:20678516
has cross-reference: PMID:21141920
has cross-reference: PMID:21531289
has cross-reference: PMID:22177408
has cross-reference: Wikipedia:Glycine_transporter_1
has_obo_namespace: chebi_ontology
has_related_synonym: GlyT1 inhibitor
has_related_synonym: GlyT1 inhibitors
has_related_synonym: glycine transporter 1 inhibitors
id: CHEBI:64588
in subset: 3 STAR

glycine receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates glycine receptors
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glycine receptor agonists
id: CHEBI:64589
in subset: 3 STAR

EC 1.8.1.9 (thioredoxin reductase) inhibitor
type: Class
subclass of: EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9).
imported from: chebi.owl
has cross-reference: Wikipedia:Thioredoxin_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.8.1.9 (thioredoxin reductase) inhibitors
has_related_synonym: EC 1.8.1.9 inhibitor
has_related_synonym: EC 1.8.1.9 inhibitors
has_related_synonym: NADP-thioredoxin reductase inhibitor
has_related_synonym: NADP-thioredoxin reductase inhibitors
has_related_synonym: NADPH-thioredoxin reductase inhibitor
has_related_synonym: NADPH-thioredoxin reductase inhibitors
has_related_synonym: NADPH2:oxidized thioredoxin oxidoreductase inhibitor
has_related_synonym: NADPH2:oxidized thioredoxin oxidoreductase inhibitors
has_related_synonym: TrxR inhibitor
has_related_synonym: TrxR inhibitors
has_related_synonym: thioredoxin reductase (EC 1.8.1.9) inhibitor
has_related_synonym: thioredoxin reductase (EC 1.8.1.9) inhibitors
has_related_synonym: thioredoxin reductase (NADPH) inhibitor
has_related_synonym: thioredoxin reductase (NADPH) inhibitors
has_related_synonym: thioredoxin reductase inhibitor
has_related_synonym: thioredoxin reductase inhibitors
has_related_synonym: thioredoxin-disulfide reductase inhibitor
has_related_synonym: thioredoxin-disulfide reductase inhibitors
has_related_synonym: thioredoxin:NADP+ oxidoreductase inhibitor
has_related_synonym: thioredoxin:NADP+ oxidoreductase inhibitors
id: CHEBI:64670
in subset: 3 STAR

EC 2.3.1.26 (sterol O-acyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of acyl-CoA:cholesterol acyltransferase (EC 2.3.1.26).
imported from: chebi.owl
has cross-reference: Wikipedia:Sterol_O-acyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: ACAT inhibitor
has_related_synonym: ACAT inhibitors
has_related_synonym: EC 2.3.1.26 (sterol O-acyltransferase) inhibitors
has_related_synonym: EC 2.3.1.26 inhibitor
has_related_synonym: EC 2.3.1.26 inhibitors
has_related_synonym: acyl coenzyme A-cholesterol-O-acyltransferase inhibitor
has_related_synonym: acyl coenzyme A-cholesterol-O-acyltransferase inhibitors
has_related_synonym: acyl-CoA:cholesterol O-acyltransferase inhibitor
has_related_synonym: acyl-CoA:cholesterol acyltransferase inhibitor
has_related_synonym: acyl-CoA:cholesterol acyltransferase inhibitors
has_related_synonym: acylcoenzyme A:cholesterol O-acyltransferase inhibitor
has_related_synonym: acylcoenzyme A:cholesterol O-acyltransferase inhibitors
has_related_synonym: cholesterol acyltransferase inhibitor
has_related_synonym: cholesterol acyltransferase inhibitors
has_related_synonym: cholesterol ester synthase inhibitor
has_related_synonym: cholesterol ester synthase inhibitors
has_related_synonym: cholesterol ester synthetase inhibitor
has_related_synonym: cholesterol ester synthetase inhibitors
has_related_synonym: cholesteryl ester synthetase inhibitor
has_related_synonym: cholesteryl ester synthetase inhibitors
has_related_synonym: sterol O-acyltransferase (EC 2.3.1.26) inhibitor
has_related_synonym: sterol O-acyltransferase (EC 2.3.1.26) inhibitors
has_related_synonym: sterol O-acyltransferase inhibitor
has_related_synonym: sterol O-acyltransferase inhibitors
has_related_synonym: sterol-ester synthase inhibitor
has_related_synonym: sterol-ester synthase inhibitors
has_related_synonym: sterol-ester synthetase inhibitor
has_related_synonym: sterol-ester synthetase inhibitors
id: CHEBI:64696
in subset: 3 STAR

acyl-CoA:cholesterol acyltransferase 2 inhibitor
type: Class
subclass of: EC 2.3.1.26 (sterol O-acyltransferase) inhibitor
textual definition: A sterol O-acyltransferase inhibitor that specifically inhibits acyl-CoA:cholesterol acyltransferase 2.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ACAT-2 inhibitor
has_related_synonym: ACAT-2 inhibitors
has_related_synonym: acyl-CoA:cholesterol acyltransferase 2 inhibitors
id: CHEBI:64697
in subset: 3 STAR

EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor
type: Class
subclass of: EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
textual definition: An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of phosphatidylinositol-specific phospholipase C (EC 3.1.4.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Phosphatidylinositol-specific_phospholipase_C
has_obo_namespace: chebi_ontology
has_related_synonym: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitor
has_related_synonym: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitors
has_related_synonym: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitor
has_related_synonym: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitors
has_related_synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase inhibitor
has_related_synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase inhibitors
has_related_synonym: EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitors
has_related_synonym: EC 3.1.4.11 inhibitor
has_related_synonym: EC 3.1.4.11 inhibitors
has_related_synonym: PI-PLC inhibitor
has_related_synonym: PI-PLC inhibitors
has_related_synonym: monophosphatidylinositol phosphodiesterase inhibitor
has_related_synonym: monophosphatidylinositol phosphodiesterase inhibitors
has_related_synonym: phosphatidylinositol phospholipase C inhibitor
has_related_synonym: phosphatidylinositol phospholipase C inhibitors
has_related_synonym: phosphatidylinositol-specific phospholipase C inhibitor
has_related_synonym: phosphatidylinositol-specific phospholipase C inhibitors
has_related_synonym: phosphoinositidase C inhibitor
has_related_synonym: phosphoinositidase C inhibitors
has_related_synonym: phosphoinositide phospholipase C (EC 3.1.4.11) inhibitor
has_related_synonym: phosphoinositide phospholipase C (EC 3.1.4.11) inhibitors
has_related_synonym: phosphoinositide phospholipase C inhibitor
has_related_synonym: phosphoinositide phospholipase C inhibitors
has_related_synonym: triphosphoinositide phosphodiesterase inhibitor
has_related_synonym: triphosphoinositide phosphodiesterase inhibitors
id: CHEBI:64763
in subset: 3 STAR

cosmetic
type: Class
subclass of: application
textual definition: The role played by a substance in enhancing the appearance or odour of the human body; a name given to the substance itself or to a component of it.
imported from: chebi.owl
has cross-reference: Wikipedia:Cosmetics
has_obo_namespace: chebi_ontology
has_related_synonym: cosmetic component
has_related_synonym: cosmetics
id: CHEBI:64857
in subset: 3 STAR

poison
type: Class
subclass of: biological role
textual definition: Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
imported from: chebi.owl
has cross-reference: Wikipedia:Poison
has_obo_namespace: chebi_ontology
has_related_synonym: poisonous agent
has_related_synonym: poisonous agents
has_related_synonym: poisonous substance
has_related_synonym: poisonous substances
has_related_synonym: poisons
has_related_synonym: toxic agent
has_related_synonym: toxic agents
has_related_synonym: toxic substance
has_related_synonym: toxic substances
id: CHEBI:64909
in subset: 3 STAR

antimitotic
type: Class
subclass of: pharmacological role
textual definition: Any compound that inhibits cell division (mitosis).
imported from: chebi.owl
has cross-reference: Wikipedia:Mitotic_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: antimitotics
has_related_synonym: mitosis inhibitor
has_related_synonym: mitosis inhibitors
has_related_synonym: mitotic inhibitor
has_related_synonym: mitotic inhibitors
id: CHEBI:64911
in subset: 3 STAR

antimycobacterial drug
type: Class
subclass of: antibacterial drug
textual definition: A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antimycobacterial agent
has_related_synonym: antimycobacterial agents
has_related_synonym: antimycobacterial drugs
has_related_synonym: antimycobacterials
has_related_synonym: antimycobacterium
id: CHEBI:64912
in subset: 3 STAR

antiplasmodial drug
type: Class
subclass of: antiparasitic agent
subclass of: antiprotozoal drug
textual definition: An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antiplasmodial agent
has_related_synonym: antiplasmodial agents
has_related_synonym: antiplasmodial drugs
has_related_synonym: antiplasmodium agent
has_related_synonym: antiplasmodium agents
has_related_synonym: antiplasmodium drug
has_related_synonym: antiplasmodium drugs
id: CHEBI:64915
in subset: 3 STAR

EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of diacylglycerol O-acyltransferase (EC 2.3.1.20).
imported from: chebi.owl
has cross-reference: Wikipedia:Dgat
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2-diacylglycerol acyltransferase inhibitor
has_related_synonym: 1,2-diacylglycerol acyltransferase inhibitors
has_related_synonym: DGAT inhibitor
has_related_synonym: DGAT inhibitors
has_related_synonym: EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitors
has_related_synonym: EC 2.3.1.20 inhibitor
has_related_synonym: EC 2.3.1.20 inhibitors
has_related_synonym: acyl-CoA:1,2-diacylglycerol O-acyltransferase inhibitor
has_related_synonym: acyl-CoA:1,2-diacylglycerol O-acyltransferase inhibitors
has_related_synonym: diacylglycerol O-acyltransferase (EC 2.3.1.20) inhibitor
has_related_synonym: diacylglycerol O-acyltransferase (EC 2.3.1.20) inhibitors
has_related_synonym: diacylglycerol O-acyltransferase inhibitor
has_related_synonym: diacylglycerol O-acyltransferase inhibitors
has_related_synonym: diacylglycerol acyltransferase inhibitor
has_related_synonym: diacylglycerol acyltransferase inhibitors
has_related_synonym: diglyceride O-acyltransferase inhibitor
has_related_synonym: diglyceride O-acyltransferase inhibitors
has_related_synonym: diglyceride acyltransferase inhibitor
has_related_synonym: diglyceride acyltransferase inhibitors
has_related_synonym: palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase inhibitor
has_related_synonym: palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase inhibitors
id: CHEBI:64919
in subset: 3 STAR

EC 6.5.1.1 [DNA ligase (ATP)] inhibitor
type: Class
subclass of: EC 6.5.1.* (DNA/RNA repair enzymes) inhibitor
textual definition: An EC 6.5.1.* (DNA/RNA repair enzymes) inhibitor that interferes with the action of DNA ligase (ATP), EC 6.5.1.1.
imported from: chebi.owl
has cross-reference: Wikipedia:Dna_Ligase
has_obo_namespace: chebi_ontology
has_related_synonym: DNA joinase inhibitor
has_related_synonym: DNA joinase inhibitors
has_related_synonym: DNA ligase (ATP) (EC 6.5.1.1) inhibitor
has_related_synonym: DNA ligase (ATP) (EC 6.5.1.1) inhibitors
has_related_synonym: DNA ligase (ATP) inhibitor
has_related_synonym: DNA ligase inhibitor
has_related_synonym: DNA ligase inhibitors
has_related_synonym: DNA repair enzyme inhibitor
has_related_synonym: DNA repair enzyme inhibitors
has_related_synonym: DNA-joining enzyme inhibitor
has_related_synonym: DNA-joining enzyme inhibitors
has_related_synonym: EC 6.5.1.1 (DNA ligase (ATP)) inhibitor
has_related_synonym: EC 6.5.1.1 (DNA ligase (ATP)) inhibitors
has_related_synonym: EC 6.5.1.1 [DNA ligase (ATP)] inhibitors
has_related_synonym: EC 6.5.1.1 inhibitor
has_related_synonym: EC 6.5.1.1 inhibitors
has_related_synonym: deoxyribonucleate ligase inhibitor
has_related_synonym: deoxyribonucleate ligase inhibitors
has_related_synonym: deoxyribonucleic acid joinase inhibitor
has_related_synonym: deoxyribonucleic acid joinase inhibitors
has_related_synonym: deoxyribonucleic acid ligase inhibitor
has_related_synonym: deoxyribonucleic acid ligase inhibitors
has_related_synonym: deoxyribonucleic acid repair enzyme inhibitor
has_related_synonym: deoxyribonucleic acid repair enzyme inhibitors
has_related_synonym: deoxyribonucleic acid-joining enzyme inhibitor
has_related_synonym: deoxyribonucleic acid-joining enzyme inhibitors
has_related_synonym: deoxyribonucleic joinase inhibitor
has_related_synonym: deoxyribonucleic joinase inhibitors
has_related_synonym: deoxyribonucleic ligase inhibitor
has_related_synonym: deoxyribonucleic ligase inhibitors
has_related_synonym: deoxyribonucleic repair enzyme inhibitor
has_related_synonym: deoxyribonucleic repair enzyme inhibitors
has_related_synonym: deoxyribonucleic-joining enzyme inhibitor
has_related_synonym: deoxyribonucleic-joining enzyme inhibitors
has_related_synonym: polydeoxyribonucleotide synthase (ATP) inhibitor
has_related_synonym: sealase inhibitor
has_related_synonym: sealase inhibitors
id: CHEBI:64920
in subset: 3 STAR

EC 3.4.21.37 (leukocyte elastase) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the activity of leukocyte elastase (EC 3.4.21.37).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.37 (leukocyte elastase) inhibitors
has_related_synonym: EC 3.4.21.37 inhibitor
has_related_synonym: EC 3.4.21.37 inhibitors
has_related_synonym: elastase inhibitor
has_related_synonym: elastase inhibitors
has_related_synonym: elaszym inhibitor
has_related_synonym: elaszym inhibitors
has_related_synonym: granulocyte elastase inhibitor
has_related_synonym: granulocyte elastase inhibitors
has_related_synonym: leukocyte elastase (EC 3.4.21.37) inhibitor
has_related_synonym: leukocyte elastase (EC 3.4.21.37) inhibitors
has_related_synonym: leukocyte elastase inhibitor
has_related_synonym: lysosomal elastase inhibitor
has_related_synonym: lysosomal elastase inhibitors
has_related_synonym: neutrophil elastase inhibitor
has_related_synonym: neutrophil elastase inhibitors
has_related_synonym: polymorphonuclear leukocyte elastase inhibitor
has_related_synonym: polymorphonuclear leukocyte elastase inhibitors
has_related_synonym: serine elastase inhibitor
has_related_synonym: serine elastase inhibitors
id: CHEBI:64922
in subset: 3 STAR

hepatitis C protease inhibitor
type: Class
subclass of: protease inhibitor
textual definition: An inhibitor of hepatitis C protease, an enzyme required for production of proteins needed for viral assembly.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hepatitis C protease inhibitors
id: CHEBI:64924
in subset: 3 STAR

serine protease inhibitor
type: Class
subclass of: protease inhibitor
textual definition: Any protease inhibitor that restricts the action of a serine protease.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: serine protease inhibitors
has_related_synonym: serine proteinase inhibitor
has_related_synonym: serine proteinase inhibitors
id: CHEBI:64926
in subset: 3 STAR

cathepsin B inhibitor
type: Class
subclass of: cysteine protease inhibitor
textual definition: A cysteine protease inhibitor which inhibits cathepsin B (EC 3.4.22.1).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.22.1 inhibitor
has_related_synonym: EC 3.4.22.1 inhibitors
has_related_synonym: cathepsin B inhibitors
has_related_synonym: cathepsin B1 inhibitor
has_related_synonym: cathepsin B1 inhibitors
has_related_synonym: cathepsin II inhibitor
has_related_synonym: cathepsin II inhibitors
id: CHEBI:64932
in subset: 3 STAR

melanin synthesis inhibitor
type: Class
subclass of: depigmentation drug
textual definition: A depigmentation agent which inhibits the synthesis of melanin.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: melanin biosynthesis inhibitor
has_related_synonym: melanin biosynthesis inhibitors
has_related_synonym: melanin synthesis inhibitors
has_related_synonym: melanogenesis inhibitor
has_related_synonym: melanogenesis inhibitors
id: CHEBI:64933
in subset: 3 STAR

EC 3.4.21.1 (chymotrypsin) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of chymotrypsin (EC 3.4.21.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Chymotrypsin
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.1 (chymotrypsin) inhibitors
has_related_synonym: EC 3.4.21.1 inhibitor
has_related_synonym: EC 3.4.21.1 inhibitors
has_related_synonym: alpha-chymar inhibitor
has_related_synonym: alpha-chymar inhibitors
has_related_synonym: alpha-chymar ophth inhibitor
has_related_synonym: alpha-chymar ophth inhibitors
has_related_synonym: alpha-chymotrypsin inhibitor
has_related_synonym: alpha-chymotrypsin inhibitors
has_related_synonym: avazyme inhibitor
has_related_synonym: avazyme inhibitors
has_related_synonym: chymar inhibitor
has_related_synonym: chymar inhibitors
has_related_synonym: chymotest inhibitor
has_related_synonym: chymotest inhibitors
has_related_synonym: chymotrypsin (EC 3.4.21.1) inhibitor
has_related_synonym: chymotrypsin (EC 3.4.21.1) inhibitors
has_related_synonym: chymotrypsin inhibitor
has_related_synonym: chymotrypsin inhibitors
has_related_synonym: chymotrypsins A and B inhibitor
has_related_synonym: chymotrypsins A and B inhibitors
has_related_synonym: chymotrypsins A inhibitor
has_related_synonym: chymotrypsins A inhibitors
has_related_synonym: chymotrypsins B inhibitor
has_related_synonym: chymotrypsins B inhibitors
has_related_synonym: enzeon inhibitor
has_related_synonym: enzeon inhibitors
has_related_synonym: quimar inhibitor
has_related_synonym: quimar inhibitors
has_related_synonym: quimotrase inhibitor
has_related_synonym: quimotrase inhibitors
id: CHEBI:64943
in subset: 3 STAR

anti-HIV agent
type: Class
subclass of: antiviral agent
textual definition: An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-AIDS agent
has_related_synonym: anti-AIDS agents
has_related_synonym: anti-HIV agents
id: CHEBI:64946
in subset: 3 STAR

anti-HIV-1 agent
type: Class
subclass of: anti-HIV agent
textual definition: An anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-HIV-1 agents
has_related_synonym: anti-HTLV-III agent
has_related_synonym: anti-HTLV-III agents
has_related_synonym: anti-LAV agent
has_related_synonym: anti-LAV agents
id: CHEBI:64947
in subset: 3 STAR

anti-HIV-2 agent
type: Class
subclass of: anti-HIV agent
textual definition: An anti-HIV agent that destroys or inhibits the replication of HIV-2, the less infective and less virulent of the two types of HIV virus.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-HIV-2 agents
id: CHEBI:64949
in subset: 3 STAR

anti-HBV agent
type: Class
subclass of: antiviral agent
textual definition: An antiviral agent that destroys or inhibits the replication of the hepatitis B virus.
imported from: chebi.owl
has cross-reference: PMID:20712567
has_obo_namespace: chebi_ontology
has_related_synonym: anti-HBV agents
has_related_synonym: anti-hepatitis B virus agent
has_related_synonym: anti-hepatitis B virus agents
id: CHEBI:64951
in subset: 3 STAR

anti-HSV agent
type: Class
subclass of: antiviral agent
textual definition: An antiviral agent that destroys or inhibits the replication of the herpes simplex virus (also known as the human herpes virus).
imported from: chebi.owl
has cross-reference: Wikipedia:Herpes_simplex_virus
has_obo_namespace: chebi_ontology
has_related_synonym: anti-HHV agent
has_related_synonym: anti-HHV agents
has_related_synonym: anti-HSV agents
has_related_synonym: anti-herpes simplex virus agent
has_related_synonym: anti-herpes simplex virus agents
has_related_synonym: anti-human herpes virus agent
has_related_synonym: anti-human herpes virus agents
id: CHEBI:64952
in subset: 3 STAR

anti-HSV-1 agent
type: Class
subclass of: anti-HSV agent
textual definition: An anti-HSV agent agent that destroys or inhibits the replication of herpes simplex virus-1.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-HHV-1 agent
has_related_synonym: anti-HHV-1 agents
has_related_synonym: anti-HHV-I agent
has_related_synonym: anti-HHV-I agents
has_related_synonym: anti-HSV-1 agents
has_related_synonym: anti-HSV-I agent
has_related_synonym: anti-HSV-I agents
has_related_synonym: anti-human herpes virus-1 agent
has_related_synonym: anti-human herpes virus-1 agents
has_related_synonym: anti-human herpes virus-I agent
has_related_synonym: anti-human herpes virus-I agents
id: CHEBI:64953
in subset: 3 STAR

anti-HSV-2 agent
type: Class
subclass of: anti-HSV agent
textual definition: An anti-HSV agent agent that destroys or inhibits the replication of herpes simplex virus-2.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-HHV-2 agent
has_related_synonym: anti-HHV-2 agents
has_related_synonym: anti-HHV-II agent
has_related_synonym: anti-HHV-II agents
has_related_synonym: anti-HSV-2 agents
has_related_synonym: anti-HSV-II agent
has_related_synonym: anti-HSV-II agents
has_related_synonym: anti-human herpes virus-2 agent
has_related_synonym: anti-human herpes virus-2 agents
has_related_synonym: anti-human herpes virus-II agent
has_related_synonym: anti-human herpes virus-II agents
id: CHEBI:64954
in subset: 3 STAR

EC 3.2.1.166 (heparanase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of heparanase (EC 3.2.1.166).
imported from: chebi.owl
has cross-reference: Wikipedia:Heparanase
has_obo_namespace: chebi_ontology
has_related_synonym: C1A heparanase inhibitor
has_related_synonym: C1A heparanase inhibitors
has_related_synonym: EC 3.2.1.166 (heparanase) inhibitors
has_related_synonym: HPSE inhibitor
has_related_synonym: HPSE inhibitors
has_related_synonym: Hpa1 heparanase inhibitor
has_related_synonym: Hpa1 heparanase inhibitors
has_related_synonym: Hpa1 inhibitor
has_related_synonym: Hpa1 inhibitors
has_related_synonym: heparan sulfate N-sulfo-D-glucosamine endoglucanase inhibitor
has_related_synonym: heparan sulfate N-sulfo-D-glucosamine endoglucanase inhibitors
has_related_synonym: heparanase (EC 3.2.1.166) inhibitor
has_related_synonym: heparanase (EC 3.2.1.166) inhibitors
has_related_synonym: heparanase 1 inhibitor
has_related_synonym: heparanase 1 inhibitors
has_related_synonym: heparanase inhibitor
has_related_synonym: heparanase inhibitors
has_related_synonym: heparanase-1 inhibitor
has_related_synonym: heparanase-1 inhibitors
id: CHEBI:64955
in subset: 3 STAR

EC 3.4.21.39 (chymase) inhibitor
type: Class
subclass of: protease inhibitor
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of chymase (EC 3.4.21.39).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.39 (chymase) inhibitors
has_related_synonym: EC 3.4.21.39 inhibitor
has_related_synonym: EC 3.4.21.39 inhibitors
has_related_synonym: SK protease inhibitor
has_related_synonym: SK protease inhibitors
has_related_synonym: chymase (EC 3.4.21.39) inhibitor
has_related_synonym: chymase (EC 3.4.21.39) inhibitors
has_related_synonym: chymase inhibitor
has_related_synonym: chymase inhibitors
has_related_synonym: mast cell protease I inhibitor
has_related_synonym: mast cell protease I inhibitors
has_related_synonym: skeletal muscle (SK) protease inhibitor
has_related_synonym: skeletal muscle (SK) protease inhibitors
has_related_synonym: skeletal muscle protease inhibitor
has_related_synonym: skeletal muscle protease inhibitors
has_related_synonym: skin chymotryptic proteinase inhibitor
has_related_synonym: skin chymotryptic proteinase inhibitors
id: CHEBI:64957
in subset: 3 STAR

EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
type: Class
subclass of: lipoxygenase inhibitor
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
textual definition: A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 5-LOX inhibitor
has_related_synonym: 5-LOX inhibitors
has_related_synonym: 5-lipoxygenase inhibitor
has_related_synonym: 5-lipoxygenase inhibitors
has_related_synonym: 5delta-lipoxygenase inhibitor
has_related_synonym: 5delta-lipoxygenase inhibitors
has_related_synonym: C-5-lipoxygenase inhibitor
has_related_synonym: C-5-lipoxygenase inhibitors
has_related_synonym: EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitors
has_related_synonym: EC 1.13.11.34 inhibitor
has_related_synonym: EC 1.13.11.34 inhibitors
has_related_synonym: LTA synthase inhibitor
has_related_synonym: LTA synthase inhibitors
has_related_synonym: arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitor
has_related_synonym: arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitors
has_related_synonym: arachidonate 5-lipoxygenase inhibitor
has_related_synonym: arachidonate 5-lipoxygenase inhibitors
has_related_synonym: arachidonic 5-lipoxygenase inhibitor
has_related_synonym: arachidonic 5-lipoxygenase inhibitors
has_related_synonym: arachidonic acid 5-lipoxygenase inhibitor
has_related_synonym: arachidonic acid 5-lipoxygenase inhibitors
has_related_synonym: delta(5)-lipoxygenase inhibitor
has_related_synonym: delta(5)-lipoxygenase inhibitors
has_related_synonym: leukotriene A4 synthase inhibitor
has_related_synonym: leukotriene A4 synthase inhibitors
has_related_synonym: leukotriene-A4 synthase inhibitor
has_related_synonym: leukotriene-A4 synthase inhibitors
id: CHEBI:64964
in subset: 3 STAR

EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor
type: Class
subclass of: lipoxygenase inhibitor
textual definition: A lipoxygenase inhibitor that interferes with the action of arachidonate 12-lipoxygenase (EC 1.13.11.31).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 12-LOX inhibitor
has_related_synonym: 12-LOX inhibitors
has_related_synonym: 12-lipoxygenase inhibitor
has_related_synonym: 12-lipoxygenase inhibitors
has_related_synonym: 12S-lipoxygenase inhibitor
has_related_synonym: 12S-lipoxygenase inhibitors
has_related_synonym: 5delta-lipoxygenase inhibitor
has_related_synonym: 5delta-lipoxygenase inhibitors
has_related_synonym: C-5-lipoxygenase inhibitor
has_related_synonym: C-5-lipoxygenase inhibitors
has_related_synonym: EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitors
has_related_synonym: EC 1.13.11.31 inhibitor
has_related_synonym: EC 1.13.11.31 inhibitors
has_related_synonym: LTA4 synthase inhibitor
has_related_synonym: LTA4 synthase inhibitors
has_related_synonym: arachidonate 12-lipoxygenase (EC 1.13.11.31) inhibitor
has_related_synonym: arachidonate 12-lipoxygenase (EC 1.13.11.31) inhibitors
has_related_synonym: arachidonate 12-lipoxygenase inhibitor
has_related_synonym: arachidonate 12-lipoxygenase inhibitors
has_related_synonym: delta(12)-lipoxygenase inhibitor
has_related_synonym: delta(12)-lipoxygenase inhibitors
has_related_synonym: leukotriene A4 synthase inhibitor
has_related_synonym: leukotriene A4 synthase inhibitors
id: CHEBI:64995
in subset: 3 STAR

EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor
type: Class
subclass of: lipoxygenase inhibitor
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
textual definition: A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33).
imported from: chebi.owl
has cross-reference: Wikipedia:ALOX15
has_obo_namespace: chebi_ontology
has_related_synonym: 15-LOX inhibitor
has_related_synonym: 15-LOX inhibitors
has_related_synonym: 15-lipoxygenase inhibitor
has_related_synonym: 15-lipoxygenase inhibitors
has_related_synonym: EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitors
has_related_synonym: EC 1.13.11.33 inhibitor
has_related_synonym: EC 1.13.11.33 inhibitors
has_related_synonym: arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitor
has_related_synonym: arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitors
has_related_synonym: arachidonate 15-lipoxygenase inhibitor
has_related_synonym: arachidonate 15-lipoxygenase inhibitors
has_related_synonym: arachidonate:oxygen 15-oxidoreductase inhibitor
has_related_synonym: arachidonate:oxygen 15-oxidoreductase inhibitors
has_related_synonym: linoleic acid omega(6)-lipoxygenase inhibitor
has_related_synonym: linoleic acid omega(6)-lipoxygenase inhibitors
has_related_synonym: omega(6) lipoxygenase inhibitor
has_related_synonym: omega(6) lipoxygenase inhibitors
id: CHEBI:64996
in subset: 3 STAR

EC 3.1.1.3 (triacylglycerol lipase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
textual definition: Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.1.3 (triacylglycerol lipase) inhibitors
has_related_synonym: EC 3.1.1.3 inhibitor
has_related_synonym: EC 3.1.1.3 inhibitors
has_related_synonym: GEH inhibitor
has_related_synonym: GEH inhibitors
has_related_synonym: PPL inhibitor
has_related_synonym: PPL inhibitors
has_related_synonym: Tween hydrolase inhibitor
has_related_synonym: Tween hydrolase inhibitors
has_related_synonym: Tweenase inhibitor
has_related_synonym: Tweenase inhibitors
has_related_synonym: Tweenesterase inhibitor
has_related_synonym: Tweenesterase inhibitors
has_related_synonym: butyrinase inhibitor
has_related_synonym: butyrinase inhibitors
has_related_synonym: cacordase inhibitor
has_related_synonym: cacordase inhibitors
has_related_synonym: capalase L inhibitor
has_related_synonym: capalase L inhibitors
has_related_synonym: glycerol ester hydrolase inhibitor
has_related_synonym: glycerol ester hydrolase inhibitors
has_related_synonym: glycerol-ester hydrolase inhibitor
has_related_synonym: glycerol-ester hydrolase inhibitors
has_related_synonym: heparin releasable hepatic lipase inhibitor
has_related_synonym: heparin releasable hepatic lipase inhibitors
has_related_synonym: hepatic lipase inhibitor
has_related_synonym: hepatic lipase inhibitors
has_related_synonym: hepatic monoacylglycerol acyltransferase inhibitor
has_related_synonym: hepatic monoacylglycerol acyltransferase inhibitors
has_related_synonym: lipase inhibitor
has_related_synonym: lipase inhibitors
has_related_synonym: lipazin inhibitor
has_related_synonym: lipazin inhibitors
has_related_synonym: liver lipase inhibitor
has_related_synonym: liver lipase inhibitors
has_related_synonym: pancreatic lipase inhibitor
has_related_synonym: pancreatic lipase inhibitors
has_related_synonym: pancreatic triacylglycerol lipase inhibitor
has_related_synonym: pancreatic triacylglycerol lipase inhibitors
has_related_synonym: post-heparin plasma protamine-resistant lipase inhibitor
has_related_synonym: post-heparin plasma protamine-resistant lipase inhibitors
has_related_synonym: salt-resistant post-heparin lipase inhibitor
has_related_synonym: salt-resistant post-heparin lipase inhibitors
has_related_synonym: steapsin inhibitor
has_related_synonym: steapsin inhibitors
has_related_synonym: triacetinase inhibitor
has_related_synonym: triacetinase inhibitors
has_related_synonym: triacylglycerol ester hydrolase inhibitor
has_related_synonym: triacylglycerol ester hydrolase inhibitors
has_related_synonym: triacylglycerol lipase (EC 3.1.1.3) inhibitor
has_related_synonym: triacylglycerol lipase (EC 3.1.1.3) inhibitors
has_related_synonym: triacylglycerol lipase inhibitor
has_related_synonym: triacylglycerol lipase inhibitors
has_related_synonym: tributyrase inhibitor
has_related_synonym: tributyrase inhibitors
has_related_synonym: tributyrin esterase inhibitor
has_related_synonym: tributyrin esterase inhibitors
has_related_synonym: tributyrinase inhibitor
has_related_synonym: tributyrinase inhibitors
has_related_synonym: triglyceridase inhibitor
has_related_synonym: triglyceridase inhibitors
has_related_synonym: triglyceride hydrolase inhibitor
has_related_synonym: triglyceride hydrolase inhibitors
has_related_synonym: triglyceride lipase inhibitor
has_related_synonym: triglyceride lipase inhibitors
has_related_synonym: triolein hydrolase inhibitor
has_related_synonym: triolein hydrolase inhibitors
has_related_synonym: tween-hydrolysing esterase inhibitor
has_related_synonym: tween-hydrolyzing esterase inhibitors
id: CHEBI:65001
in subset: 3 STAR

anti-asthmatic agent
type: Class
subclass of: application
textual definition: Any compound that has anti-asthmatic effects.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-asthmatic agents
has_related_synonym: antiasthmatic agent
has_related_synonym: antiasthmatic agents
id: CHEBI:65023
in subset: 3 STAR

EC 4.1.1.19 (arginine decarboxylase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of arginine decarboxylase (EC 4.1.1.19).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ADC inhibitor
has_related_synonym: ADC inhibitors
has_related_synonym: EC 4.1.1.19 (arginine decarboxylase) inhibitors
has_related_synonym: EC 4.1.1.19 inhibitor
has_related_synonym: EC 4.1.1.19 inhibitors
has_related_synonym: L-arginine carboxy-lyase (agmatine-forming) inhibitor
has_related_synonym: L-arginine carboxy-lyase (agmatine-forming) inhibitors
has_related_synonym: L-arginine carboxy-lyase inhibitor
has_related_synonym: L-arginine carboxy-lyase inhibitors
has_related_synonym: SpeA inhibitor
has_related_synonym: SpeA inhibitors
has_related_synonym: arginine decarboxylase (EC 4.1.1.19) inhibitor
has_related_synonym: arginine decarboxylase (EC 4.1.1.19) inhibitors
has_related_synonym: arginine decarboxylase inhibitor
has_related_synonym: arginine decarboxylase inhibitors
id: CHEBI:65053
in subset: 3 STAR

EC 3.1.3.11 (fructose-bisphosphatase) inhibitor
type: Class
subclass of: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
textual definition: An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of fructose-bisphosphatase (EC 3.1.3.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Fructose_1,6-bisphosphatase
has_obo_namespace: chebi_ontology
has_related_synonym: D-fructose 1,6-diphosphatase inhibitor
has_related_synonym: D-fructose 1,6-diphosphatase inhibitors
has_related_synonym: D-fructose-1,6-bisphosphate 1-phosphohydrolase inhibitor
has_related_synonym: D-fructose-1,6-bisphosphate 1-phosphohydrolase inhibitors
has_related_synonym: D-fructose-1,6-bisphosphate phosphatase inhibitor
has_related_synonym: D-fructose-1,6-bisphosphate phosphatase inhibitors
has_related_synonym: EC 3.1.3.11 (fructose-bisphosphatase) inhibitors
has_related_synonym: EC 3.1.3.11 inhibitor
has_related_synonym: EC 3.1.3.11 inhibitors
has_related_synonym: FBPase inhibitor
has_related_synonym: FBPase inhibitors
has_related_synonym: fructose 1,6-bisphosphatase inhibitor
has_related_synonym: fructose 1,6-bisphosphatase inhibitors
has_related_synonym: fructose 1,6-bisphosphate 1-phosphatase inhibitor
has_related_synonym: fructose 1,6-bisphosphate 1-phosphatase inhibitors
has_related_synonym: fructose 1,6-bisphosphate phosphatase inhibitor
has_related_synonym: fructose 1,6-bisphosphate phosphatase inhibitors
has_related_synonym: fructose 1,6-diphosphatase inhibitor
has_related_synonym: fructose 1,6-diphosphatase inhibitors
has_related_synonym: fructose 1,6-diphosphate phosphatase inhibitor
has_related_synonym: fructose 1,6-diphosphate phosphatase inhibitors
has_related_synonym: fructose bisphosphate phosphatase inhibitor
has_related_synonym: fructose bisphosphate phosphatase inhibitors
has_related_synonym: fructose diphosphatase inhibitor
has_related_synonym: fructose diphosphatase inhibitors
has_related_synonym: fructose diphosphate phosphatase inhibitor
has_related_synonym: fructose diphosphate phosphatase inhibitors
has_related_synonym: fructose-bisphosphatase (EC 3.1.3.11) inhibitor
has_related_synonym: fructose-bisphosphatase (EC 3.1.3.11) inhibitors
has_related_synonym: fructose-bisphosphatase inhibitor
has_related_synonym: fructose-bisphosphatase inhibitors
has_related_synonym: hexose bisphosphatase inhibitor
has_related_synonym: hexose bisphosphatase inhibitors
has_related_synonym: hexose diphosphatase inhibitor
id: CHEBI:65056
in subset: 3 STAR

adenosine A1 receptor agonist
type: Class
subclass of: adenosine receptor agonist
textual definition: An agonist at the A1 receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_A1_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine A1 receptor agonists
id: CHEBI:65057
in subset: 3 STAR

EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of cyclopropane fatty acid synthase (EC 2.1.1.79).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CFA synthase inhibitor
has_related_synonym: CFA synthase inhibitors
has_related_synonym: EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitors
has_related_synonym: EC 2.1.1.79 inhibitor
has_related_synonym: EC 2.1.1.79 inhibitors
has_related_synonym: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclising) inhibitor
has_related_synonym: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclising) inhibitors
has_related_synonym: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing) inhibitor
has_related_synonym: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing) inhibitors
has_related_synonym: cyclopropane fatty acid synthase inhibitors
has_related_synonym: cyclopropane fatty acid synthetase inhibitor
has_related_synonym: cyclopropane fatty acid synthetase inhibitors
has_related_synonym: cyclopropane synthase inhibitor
has_related_synonym: cyclopropane synthase inhibitors
has_related_synonym: cyclopropane synthetase inhibitor
has_related_synonym: cyclopropane synthetase inhibitors
has_related_synonym: cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) inhibitor
has_related_synonym: cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) inhibitors
has_related_synonym: cyclopropane-fatty-acyl-phospholipid synthase inhibitor
has_related_synonym: cyclopropane-fatty-acyl-phospholipid synthase inhibitors
has_related_synonym: unsaturated-phospholipid methyltransferase inhibitor
has_related_synonym: unsaturated-phospholipid methyltransferase inhibitors
id: CHEBI:65064
in subset: 3 STAR

EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of site-specific DNA-methyltransferase (adenine-specific), EC 2.1.1.72.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: DNA adenine methyltransferase inhibitor
has_related_synonym: DNA adenine methyltransferase inhibitors
has_related_synonym: Dam inhibitor
has_related_synonym: Dam inhibitors
has_related_synonym: EC 2.1.1.72 (site-specific DNA-methyltransferase (adenine-specific)) inhibitor
has_related_synonym: EC 2.1.1.72 (site-specific DNA-methyltransferase (adenine-specific)) inhibitors
has_related_synonym: EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitors
has_related_synonym: EC 2.1.1.72 inhibitor
has_related_synonym: EC 2.1.1.72 inhibitors
has_related_synonym: modification methylase inhibitor
has_related_synonym: modification methylase inhibitors
has_related_synonym: restriction-modification system inhibitor
has_related_synonym: restriction-modification system inhibitors
has_related_synonym: site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) inhibitor
has_related_synonym: site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) inhibitors
has_related_synonym: site-specific DNA-methyltransferase (adenine-specific) inhibitor
has_related_synonym: site-specific DNA-methyltransferase (adenine-specific) inhibitors
id: CHEBI:65065
in subset: 3 STAR

first generation antipsychotic
type: Class
subclass of: antipsychotic agent
textual definition: Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased.
imported from: chebi.owl
has cross-reference: Wikipedia:Typical_antipsychotic
has_obo_namespace: chebi_ontology
has_related_synonym: first generation antipsychotic agent
has_related_synonym: first generation antipsychotic agents
has_related_synonym: first generation antipsychotic drug
has_related_synonym: first generation antipsychotic drugs
has_related_synonym: first generation antipsychotics
has_related_synonym: typical antipsychotic
has_related_synonym: typical antipsychotic agent
has_related_synonym: typical antipsychotic agents
has_related_synonym: typical antipsychotic drug
has_related_synonym: typical antipsychotic drugs
has_related_synonym: typical antipsychotics
id: CHEBI:65190
in subset: 3 STAR

second generation antipsychotic
type: Class
subclass of: antipsychotic agent
textual definition: Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: atypical antipsychotic
has_related_synonym: atypical antipsychotic agent
has_related_synonym: atypical antipsychotic agents
has_related_synonym: atypical antipsychotic drug
has_related_synonym: atypical antipsychotic drugs
has_related_synonym: atypical antipsychotics
has_related_synonym: second generation antipsychotic agent
has_related_synonym: second generation antipsychotic agents
has_related_synonym: second generation antipsychotic drug
has_related_synonym: second generation antipsychotic drugs
has_related_synonym: second generation antipsychotics
id: CHEBI:65191
in subset: 3 STAR

vascular endothelial growth factor receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the vascular endothelial growth factor receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:VEGF_receptors
has_obo_namespace: chebi_ontology
has_related_synonym: VEGF receptor inhibitor
has_related_synonym: VEGF receptor inhibitors
has_related_synonym: VEGFR inhibitor
has_related_synonym: VEGFR inhibitors
has_related_synonym: vascular endothelial growth factor receptor antagonists
has_related_synonym: vascular endothelial growth factor receptor inhibitor
has_related_synonym: vascular endothelial growth factor receptor inhibitors
id: CHEBI:65207
in subset: 3 STAR

EC 3.4.21.5 (thrombin) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of thrombin (EC 3.4.21.5).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: E thrombin inhibitor
has_related_synonym: E thrombin inhibitors
has_related_synonym: EC 3.4.21.5 (thrombin) inhibitors
has_related_synonym: EC 3.4.21.5 inhibitor
has_related_synonym: EC 3.4.21.5 inhibitors
has_related_synonym: activated blood-coagulation factor II inhibitor
has_related_synonym: activated blood-coagulation factor II inhibitors
has_related_synonym: beta-thrombin inhibitor
has_related_synonym: beta-thrombin inhibitors
has_related_synonym: blood-coagulation factor IIa inhibitor
has_related_synonym: blood-coagulation factor IIa inhibitors
has_related_synonym: factor IIa inhibitor
has_related_synonym: factor IIa inhibitors
has_related_synonym: fibrinogenase inhibitor
has_related_synonym: fibrinogenase inhibitors
has_related_synonym: gamma-thrombin inhibitor
has_related_synonym: gamma-thrombin inhibitors
has_related_synonym: thrombase inhibitor
has_related_synonym: thrombase inhibitors
has_related_synonym: thrombin (EC 3.4.21.5) inhibitor
has_related_synonym: thrombin (EC 3.4.21.5) inhibitors
has_related_synonym: thrombin inhibitor
has_related_synonym: thrombin inhibitors
has_related_synonym: thrombin-C inhibitor
has_related_synonym: thrombin-C inhibitors
has_related_synonym: thrombofort inhibitor
has_related_synonym: thrombofort inhibitors
has_related_synonym: tropostasin inhibitor
has_related_synonym: tropostasin inhibitors
id: CHEBI:65232
in subset: 3 STAR

EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An enzyme inhibitor that interferes with the action of mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114), a key enzyme target in the development of anti-cancer therapies.
imported from: chebi.owl
has cross-reference: PMID:18759458
has_obo_namespace: chebi_ontology
has_related_synonym: (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitor
has_related_synonym: (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitors
has_related_synonym: 1,3(1,6)-alpha-D-mannosidase inhibitor
has_related_synonym: 1,3(1,6)-alpha-D-mannosidase inhibitors
has_related_synonym: 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitor
has_related_synonym: 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase inhibitors
has_related_synonym: EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitors
has_related_synonym: EC 3.2.1.114 inhibitor
has_related_synonym: EC 3.2.1.114 inhibitors
has_related_synonym: GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase inhibitor
has_related_synonym: GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase inhibitors
has_related_synonym: Golgi alpha-mannosidase II inhibitor
has_related_synonym: Golgi alpha-mannosidase II inhibitors
has_related_synonym: ManII inhibitor
has_related_synonym: ManII inhibitors
has_related_synonym: alpha-D-mannosidase II inhibitor
has_related_synonym: alpha-D-mannosidase II inhibitors
has_related_synonym: alpha-mannosidase II inhibitor
has_related_synonym: alpha-mannosidase II inhibitors
has_related_synonym: alpha1-3,6-mannosidase inhibitor
has_related_synonym: alpha1-3,6-mannosidase inhibitors
has_related_synonym: exo-1,3-1,6-alpha-mannosidase inhibitor
has_related_synonym: exo-1,3-1,6-alpha-mannosidase inhibitors
has_related_synonym: golgi alpha-mannosidase II inhibitor
has_related_synonym: golgi alpha-mannosidase II inhibitors
has_related_synonym: mannosidase II inhibitor
has_related_synonym: mannosidase II inhibitors
has_related_synonym: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114) inhibitor
has_related_synonym: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (EC 3.2.1.114) inhibitors
has_related_synonym: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase inhibitor
has_related_synonym: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase inhibitors
id: CHEBI:65239
in subset: 3 STAR

LRH-1 agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates liver receptor homologue-1 (LRH-1).
imported from: chebi.owl
has cross-reference: Wikipedia:Liver_receptor_homolog-1
has_obo_namespace: chebi_ontology
has_related_synonym: LRH-1 agonists
has_related_synonym: NR5A2 agonist
has_related_synonym: NR5A2 agonists
has_related_synonym: liver receptor homologue-1 agonist
has_related_synonym: liver receptor homologue-1 agonists
has_related_synonym: nuclear receptor subfamily 5 group A member 2 agonist
has_related_synonym: nuclear receptor subfamily 5 group A member 2 agonists
id: CHEBI:65254
in subset: 3 STAR

food preservative
type: Class
subclass of: food additive
textual definition: Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food preservatives
id: CHEBI:65255
in subset: 3 STAR

antimicrobial food preservative
type: Class
subclass of: antimicrobial agent
subclass of: food preservative
textual definition: A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antimicrobial food preservatives
has_related_synonym: antimicrobial preservative
has_related_synonym: antimicrobial preservatives
id: CHEBI:65256
in subset: 3 STAR

GABA antagonist
type: Class
subclass of: antagonist
subclass of: GABA agent
textual definition: A compound that inhibits the action of gamma-aminobutyric acid.
imported from: chebi.owl
has cross-reference: Wikipedia:GABA_antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: GABA antagonists
has_related_synonym: gamma-aminobutyric acid receptor antagonist
has_related_synonym: gamma-aminobutyric acid receptor antagonists
id: CHEBI:65259
in subset: 3 STAR

antacid
type: Class
subclass of: drug
subclass of: pharmacological role
textual definition: Any substance which is used to neutralise stomach acidity.
imported from: chebi.owl
has cross-reference: Wikipedia:Antacid
has_obo_namespace: chebi_ontology
has_related_synonym: antacids
id: CHEBI:65265
in subset: 3 STAR

erythropeotin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates erythropeotin receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Erythropoietin_receptor
alternative_term: erythropeotin receptor agonist
has_obo_namespace: chebi_ontology
has_related_synonym: erythropoiesis-stimulating agent
has_related_synonym: erythropoiesis-stimulating agents
id: CHEBI:66894
in subset: 3 STAR

prostaglandin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates prostaglandin receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: prostaglandin receptor agonists
id: CHEBI:66900
in subset: 3 STAR

CFTR potentiator
type: Class
subclass of: membrane transport modulator
textual definition: A membrane transport modulator that restores the chloride ion transport ability of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes.
imported from: chebi.owl
has cross-reference: Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator
has_obo_namespace: chebi_ontology
has_related_synonym: CFTR potentiators
has_related_synonym: cystic fibrosis transmembrane conductance regulator potentiator
has_related_synonym: cystic fibrosis transmembrane conductance regulator potentiators
id: CHEBI:66902
in subset: 3 STAR

SMO receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that interferes with the action of smoothened (SMO) receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Smoothened
has_obo_namespace: chebi_ontology
has_related_synonym: SMO receptor antagonists
has_related_synonym: smoothened antagonist
has_related_synonym: smoothened antagonists
has_related_synonym: smoothened receptor antagonist
has_related_synonym: smoothened receptor antagonists
id: CHEBI:66908
in subset: 3 STAR

antidyskinesia agent
type: Class
subclass of: drug
textual definition: Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidyskinesia agents
has_related_synonym: antidyskinesia drug
has_related_synonym: antidyskinesia drugs
has_related_synonym: antidyskinetic agent
has_related_synonym: antidyskinetic agents
has_related_synonym: antidyskinetic drug
has_related_synonym: antidyskinetic drugs
id: CHEBI:66956
in subset: 3 STAR

nootropic agent
type: Class
subclass of: drug
textual definition: Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
imported from: chebi.owl
has cross-reference: PMID:22393531
has cross-reference: PMID:22647316
has cross-reference: PMID:22742585
has cross-reference: PMID:22795553
has cross-reference: PMID:22828638
has cross-reference: PMID:22837964
has cross-reference: Wikipedia:Nootropic
has_obo_namespace: chebi_ontology
has_related_synonym: cognitive enhancer
has_related_synonym: cognitive enhancers
has_related_synonym: intelligence enhancer
has_related_synonym: intelligence enhancers
has_related_synonym: memory enhancer
has_related_synonym: memory enhancers
has_related_synonym: neuro enhancer
has_related_synonym: neuro enhancers
has_related_synonym: nootropic
has_related_synonym: nootropic agents
has_related_synonym: nootropic drug
has_related_synonym: nootropic drugs
has_related_synonym: nootropics
has_related_synonym: smart drug
has_related_synonym: smart drugs
id: CHEBI:66980
in subset: 3 STAR

ophthalmology drug
type: Class
subclass of: drug
textual definition: Any compound used for the treatment of eye conditions or eye diseases.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ophthalmic
has_related_synonym: ophthalmic agent
has_related_synonym: ophthalmic agents
has_related_synonym: ophthalmics
has_related_synonym: ophthalmological
has_related_synonym: ophthalmologicals
has_related_synonym: ophthalmology agent
has_related_synonym: ophthalmology agents
has_related_synonym: ophthalmology drugs
id: CHEBI:66981
in subset: 3 STAR

radiation protective agent
type: Class
subclass of: protective agent
textual definition: Any compound that is able to protect normal cells from the damage caused by radiation therapy.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: radiation mitigation agent
has_related_synonym: radiation mitigation agents
has_related_synonym: radiation protective agents
has_related_synonym: radiation protective drug
has_related_synonym: radiation protective drugs
has_related_synonym: radioprotective agent
has_related_synonym: radioprotective agents
has_related_synonym: radioprotector
has_related_synonym: radioprotectors
id: CHEBI:66987
in subset: 3 STAR

sympatholytic agent
type: Class
subclass of: adrenergic agent
textual definition: Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
imported from: chebi.owl
has cross-reference: Wikipedia:Sympatholytic
has_obo_namespace: chebi_ontology
has_related_synonym: sympatholytic
has_related_synonym: sympatholytic agents
has_related_synonym: sympatholytic drug
has_related_synonym: sympatholytic drugs
has_related_synonym: sympatholytics
id: CHEBI:66991
in subset: 3 STAR

tocolytic agent
type: Class
subclass of: reproductive control drug
textual definition: Any compound used to suppress premature labour and immature birth by suppressing uterine contractions.
imported from: chebi.owl
has cross-reference: Wikipedia:Tocolytic
has_obo_namespace: chebi_ontology
has_related_synonym: anti-contraction drug
has_related_synonym: anti-contraction drugs
has_related_synonym: anti-contraction medication
has_related_synonym: anti-contraction medications
has_related_synonym: labour repressant
has_related_synonym: labour repressants
has_related_synonym: tocolytic
has_related_synonym: tocolytic agents
has_related_synonym: tocolytic drug
has_related_synonym: tocolytic drugs
has_related_synonym: tocolytics
id: CHEBI:66993
in subset: 3 STAR

cannabinoid receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates cannabinoid receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Cannabinoid_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: cannabinoid receptor agonists
id: CHEBI:67072
in subset: 3 STAR

anti-inflammatory agent
type: Class
subclass of: application
textual definition: Any compound that has anti-inflammatory effects.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-inflammatory agents
has_related_synonym: antiinflammatory agent
has_related_synonym: antiinflammatory agents
id: CHEBI:67079
in subset: 3 STAR

insect sterilant
type: Class
subclass of: chemosterilant
subclass of: insecticide
textual definition: A chemosterilant intended to sterilize insects.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: insect chemosterilant
has_related_synonym: insect chemosterilants
has_related_synonym: insect sterilants
id: CHEBI:67105
in subset: 3 STAR

ryanodine receptor agonist
type: Class
subclass of: ryanodine receptor modulator
textual definition: A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction.
imported from: chebi.owl
has cross-reference: PMID:30679133
has cross-reference: PMID:30684528
has cross-reference: PMID:31840405
has cross-reference: PMID:8597061
has cross-reference: Wikipedia:Ryanodine_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: RyR activator
has_related_synonym: RyR activators
has_related_synonym: RyR agonist
has_related_synonym: RyR agonists
has_related_synonym: RyRs activator
has_related_synonym: RyRs agonist
has_related_synonym: ryanodine receptor activator
has_related_synonym: ryanodine receptor activators
id: CHEBI:67114
in subset: 3 STAR

colorimetric reagent
type: Class
subclass of: reagent
textual definition: A reagent used in the determination of the concentration of a coloured chemical element or chemical compound in solution.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: color reagent
has_related_synonym: color reagents
has_related_synonym: colorimetric reagents
has_related_synonym: colour reagent
has_related_synonym: colour reagents
id: CHEBI:67126
in subset: 3 STAR

NMR shift reagent
type: Class
subclass of: reagent
textual definition: In NMR spectroscopy a reagent added to a solution to induce chemical shifts and thus simplify complex spectra.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NMR shift reagents
has_related_synonym: lanthanide shift reagent
has_related_synonym: lanthanide shift reagents
has_related_synonym: nuclear magnetic resonance shift reagent
has_related_synonym: nuclear magnetic resonance shift reagents
id: CHEBI:67137
in subset: 3 STAR

EC 3.4.24.3 (microbial collagenase) inhibitor
type: Class
subclass of: EC 3.4.24.* (metalloendopeptidase) inhibitor
textual definition: An EC 3.4.24.* (metalloendopeptidase) inhibitor which interferes with the action of microbial collagenase (EC 3.4.24.3, also formerly EC 3.4.4.19 and EC 3.4.99.5).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Achromobacter iophagus collagenase inhibitor
has_related_synonym: Achromobacter iophagus collagenase inhibitors
has_related_synonym: Clostridium histolyticum collagenase inhibitor
has_related_synonym: Clostridium histolyticum collagenase inhibitors
has_related_synonym: Clostridium histolyticum proteinase A inhibitor
has_related_synonym: Clostridium histolyticum proteinase A inhibitors
has_related_synonym: EC 3.4.24.3 (microbial collagenase) inhibitors
has_related_synonym: EC 3.4.24.3 inhibitor
has_related_synonym: EC 3.4.24.3 inhibitors
has_related_synonym: MMP-1 inhibitor
has_related_synonym: MMP-1 inhibitors
has_related_synonym: MMP-8 inhibitor
has_related_synonym: MMP-8 inhibitors
has_related_synonym: aspergillopeptidase C inhibitor
has_related_synonym: aspergillopeptidase C inhibitors
has_related_synonym: azocollase inhibitor
has_related_synonym: azocollase inhibitors
has_related_synonym: clostridiopeptidase A inhibitor
has_related_synonym: clostridiopeptidase A inhibitors
has_related_synonym: clostridiopeptidase I inhibitor
has_related_synonym: clostridiopeptidase I inhibitors
has_related_synonym: clostridiopeptidase II inhibitor
has_related_synonym: clostridiopeptidase II inhibitors
has_related_synonym: collagen peptidase inhibitor
has_related_synonym: collagen peptidase inhibitors
has_related_synonym: collagen protease inhibitor
has_related_synonym: collagen protease inhibitors
has_related_synonym: collagenase A inhibitor
has_related_synonym: collagenase A inhibitors
has_related_synonym: collagenase I inhibitor
has_related_synonym: collagenase I inhibitors
has_related_synonym: collagenase MMP-1 inhibitor
has_related_synonym: collagenase MMP-1 inhibitors
has_related_synonym: collagenase inhibitor
has_related_synonym: collagenase inhibitors
has_related_synonym: interstitial collagenase inhibitor
has_related_synonym: interstitial collagenase inhibitors
has_related_synonym: kollaza inhibitor
has_related_synonym: kollaza inhibitors
has_related_synonym: matrix metalloproteinase-1 inhibitor
has_related_synonym: matrix metalloproteinase-1 inhibitors
has_related_synonym: matrix metalloproteinase-18 inhibitor
has_related_synonym: matrix metalloproteinase-18 inhibitors
has_related_synonym: matrix metalloproteinase-8 inhibitor
has_related_synonym: matrix metalloproteinase-8 inhibitors
has_related_synonym: metallocollagenase inhibitor
has_related_synonym: metallocollagenase inhibitors
has_related_synonym: metalloproteinase-1 inhibitor
has_related_synonym: metalloproteinase-1 inhibitors
has_related_synonym: microbial collagenase (EC 3.4.24.3) inhibitor
has_related_synonym: microbial collagenase (EC 3.4.24.3) inhibitors
has_related_synonym: microbial collagenase inhibitor
has_related_synonym: microbial collagenase inhibitors
has_related_synonym: nucleolysin inhibitor
has_related_synonym: nucleolysin inhibitors
has_related_synonym: soycollagestin inhibitor
has_related_synonym: soycollagestin inhibitors
id: CHEBI:67189
in subset: 3 STAR

gap junctional intercellular communication inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor that interferes with the process of gap junctional intercellular communication.
imported from: chebi.owl
has cross-reference: Wikipedia:Gap_junction
has_obo_namespace: chebi_ontology
has_related_synonym: gap junctional intercellular communication inhibitors
id: CHEBI:67195
in subset: 3 STAR

retinoic acid receptor agonist
type: Class
subclass of: agonist
subclass of: retinoic acid receptor modulator
textual definition: An agonist that selectively binds to and activates a retinoic acid receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Retinoic_acid_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: retinoic acid receptor agonists
id: CHEBI:67198
in subset: 3 STAR

AP-1 antagonist
type: Class
subclass of: antagonist
textual definition: An antogonist that interferes with the action of activator protein 1 (AP-1).
imported from: chebi.owl
has cross-reference: Wikipedia:Activator_protein_1
has_obo_namespace: chebi_ontology
has_related_synonym: AP-1 antagonists
has_related_synonym: activator protein-1 antagonist
has_related_synonym: activator protein-1 antagonists
id: CHEBI:67199
in subset: 3 STAR

provitamin A
type: Class
subclass of: provitamin
textual definition: A provitamin that can be converted into vitamin A by enzymes from animal tissues.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: provitamin As
id: CHEBI:67200
in subset: 3 STAR

EC 3.2.1.45 (glucosylceramidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of glucosylceramidase (EC 3.2.1.45).
imported from: chebi.owl
has cross-reference: Wikipedia:Glucosylceramidase
has_obo_namespace: chebi_ontology
has_related_synonym: D-glucosyl-N-acylsphingosine glucohydrolase inhibitor
has_related_synonym: D-glucosyl-N-acylsphingosine glucohydrolase inhibitors
has_related_synonym: EC 3.2.1.45 (glucosylceramidase) inhibitors
has_related_synonym: EC 3.2.1.45 inhibitor
has_related_synonym: EC 3.2.1.45 inhibitors
has_related_synonym: GlcCer-beta-glucosidase inhibitor
has_related_synonym: GlcCer-beta-glucosidase inhibitors
has_related_synonym: acid beta-glucosidase inhibitor
has_related_synonym: acid beta-glucosidase inhibitors
has_related_synonym: acid-beta-glucosidase inhibitor
has_related_synonym: acid-beta-glucosidase inhibitors
has_related_synonym: beta-D-glucocerebrosidase inhibitor
has_related_synonym: beta-D-glucocerebrosidase inhibitors
has_related_synonym: beta-glucosylceramidase inhibitor
has_related_synonym: beta-glucosylceramidase inhibitors
has_related_synonym: ceramide glucosidase inhibitor
has_related_synonym: ceramide glucosidase inhibitors
has_related_synonym: glucocerebrosidase inhibitor
has_related_synonym: glucocerebrosidase inhibitors
has_related_synonym: glucosphingosine glucosylhydrolase inhibitor
has_related_synonym: glucosphingosine glucosylhydrolase inhibitors
has_related_synonym: glucosylceramidase (EC 3.2.1.45) inhibitor
has_related_synonym: glucosylceramidase (EC 3.2.1.45) inhibitors
has_related_synonym: glucosylceramidase inhibitor
has_related_synonym: glucosylceramidase inhibitors
has_related_synonym: glucosylcerebrosidase inhibitor
has_related_synonym: glucosylcerebrosidase inhibitors
has_related_synonym: glucosylsphingosine beta-D-glucosidase inhibitor
has_related_synonym: glucosylsphingosine beta-D-glucosidase inhibitors
has_related_synonym: glucosylsphingosine beta-glucosidase inhibitor
has_related_synonym: glucosylsphingosine beta-glucosidase inhibitors
has_related_synonym: psychosine hydrolase inhibitor
has_related_synonym: psychosine hydrolase inhibitors
id: CHEBI:67230
in subset: 3 STAR

EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of sucrose alpha-glucosidase (EC 3.2.1.48).
imported from: chebi.owl
has cross-reference: Wikipedia:Sucrose_alpha-glucosidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitors
has_related_synonym: EC 3.2.1.48 inhibitor
has_related_synonym: EC 3.2.1.48 inhibitors
has_related_synonym: intestinal sucrase inhibitor
has_related_synonym: intestinal sucrase inhibitors
has_related_synonym: sucrase (invertase) inhibitor
has_related_synonym: sucrase (invertase) inhibitors
has_related_synonym: sucrase inhibitor
has_related_synonym: sucrase inhibitors
has_related_synonym: sucrase-isomaltase inhibitor
has_related_synonym: sucrase-isomaltase inhibitors
has_related_synonym: sucrose alpha-glucohydrolase inhibitor
has_related_synonym: sucrose alpha-glucohydrolase inhibitors
has_related_synonym: sucrose alpha-glucosidase (EC 3.2.1.48) inhibitor
has_related_synonym: sucrose alpha-glucosidase (EC 3.2.1.48) inhibitors
has_related_synonym: sucrose alpha-glucosidase inhibitor
has_related_synonym: sucrose alpha-glucosidase inhibitors
has_related_synonym: sucrose-alpha-D-glucohydrolase inhibitor
has_related_synonym: sucrose-alpha-D-glucohydrolase inhibitors
id: CHEBI:67231
in subset: 3 STAR

EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that inhibits the action of sucrose oligo-1,6-glucosidase (EC 3.2.1.10).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitors
has_related_synonym: EC 3.2.1.10 inhibitor
has_related_synonym: EC 3.2.1.10 inhibitors
has_related_synonym: alpha-limit dextrinase inhibitor
has_related_synonym: alpha-limit dextrinase inhibitors
has_related_synonym: dextrin 6-glucanohydrolase inhibitor
has_related_synonym: dextrin 6-glucanohydrolase inhibitors
has_related_synonym: dextrin 6alpha-glucanohydrolase inhibitor
has_related_synonym: dextrin 6alpha-glucanohydrolase inhibitors
has_related_synonym: exo-oligo-1,6-glucosidase inhibitor
has_related_synonym: exo-oligo-1,6-glucosidase inhibitors
has_related_synonym: isomaltase inhibitor
has_related_synonym: isomaltase inhibitors
has_related_synonym: oligo-1,6-glucosidase (EC 3.2.1.10) inhibitor
has_related_synonym: oligo-1,6-glucosidase (EC 3.2.1.10) inhibitors
has_related_synonym: oligo-1,6-glucosidase inhibitor
has_related_synonym: oligo-1,6-glucosidase inhibitors
has_related_synonym: oligosaccharide alpha-1,6-glucohydrolase inhibitor
has_related_synonym: oligosaccharide alpha-1,6-glucohydrolase inhibitors
has_related_synonym: sucrase-isomaltase inhibitor
has_related_synonym: sucrase-isomaltase inhibitors
id: CHEBI:67232
in subset: 3 STAR

EC 3.2.1.20 (alpha-glucosidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-glucosidase (EC 3.2.1.20).
imported from: chebi.owl
has_alternative_id: CHEBI:50628
has cross-reference: Wikipedia:Alpha-glucosidase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.20 (alpha-glucosidase) inhibitors
has_related_synonym: EC 3.2.1.20 inhibitor
has_related_synonym: EC 3.2.1.20 inhibitors
has_related_synonym: alpha-1,4-glucosidase inhibitor
has_related_synonym: alpha-1,4-glucosidase inhibitors
has_related_synonym: alpha-D-glucosidase inhibitor
has_related_synonym: alpha-D-glucosidase inhibitors
has_related_synonym: alpha-glucopyranosidase inhibitor
has_related_synonym: alpha-glucopyranosidase inhibitors
has_related_synonym: alpha-glucosidase (EC 3.2.1.20) inhibitor
has_related_synonym: alpha-glucosidase (EC 3.2.1.20) inhibitors
has_related_synonym: alpha-glucosidase inhibitor
has_related_synonym: alpha-glucosidase inhibitors
has_related_synonym: alpha-glucoside hydrolase inhibitor
has_related_synonym: alpha-glucoside hydrolase inhibitors
has_related_synonym: glucoinvertase inhibitor
has_related_synonym: glucoinvertase inhibitors
has_related_synonym: glucosidoinvertase inhibitor
has_related_synonym: glucosidoinvertase inhibitors
has_related_synonym: glucosidosucrase inhibitor
has_related_synonym: glucosidosucrase inhibitors
has_related_synonym: maltase inhibitor
has_related_synonym: maltase inhibitors
has_related_synonym: maltase-glucoamylase inhibitor
has_related_synonym: maltase-glucoamylase inhibitors
id: CHEBI:67239
in subset: 3 STAR

EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein geranylgeranyltransferase type I (EC 2.5.1.59).
imported from: chebi.owl
has cross-reference: Wikipedia:Protein_geranylgeranyltransferase_type_I
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitors
has_related_synonym: EC 2.5.1.59 inhibitor
has_related_synonym: EC 2.5.1.59 inhibitors
has_related_synonym: GGTase I inhibitor
has_related_synonym: GGTase I inhibitors
has_related_synonym: geranylgeranyl-diphosphate:protein-cysteine geranyltransferase inhibitor
has_related_synonym: geranylgeranyl-diphosphate:protein-cysteine geranyltransferase inhibitors
has_related_synonym: geranylgeranyltransferase type I inhibitor
has_related_synonym: geranylgeranyltransferase type I inhibitors
has_related_synonym: protein geranylgeranyltransferase type I (EC 2.5.1.59) inhibitor
has_related_synonym: protein geranylgeranyltransferase type I (EC 2.5.1.59) inhibitors
has_related_synonym: protein geranylgeranyltransferase type I inhibitor
has_related_synonym: protein geranylgeranyltransferase type I inhibitors
id: CHEBI:67267
in subset: 3 STAR

HIV-1 integrase inhibitor
type: Class
subclass of: anti-HIV-1 agent
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An inhibitor of HIV-1 integrase, an enzyme required for the integration of the genetic material of the retrovirus into the DNA of the infected cells.
imported from: chebi.owl
has cross-reference: Wikipedia:Discovery_and_development_of_integrase_inhibitors
has_obo_namespace: chebi_ontology
id: CHEBI:67268
in subset: 3 STAR

metformin
type: Class
subclass of: molecular entity
textual definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
imported from: chebi.owl
charge: 0
formula: C4H11N5
inchi: InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
inchikey: XZWYZXLIPXDOLR-UHFFFAOYSA-N
mass: 129.167
monoisotopicmass: 129.10145
smiles: CN(C)C(=N)NC(N)=N
has cross-reference: CAS:657-24-9
has cross-reference: DrugBank:DB00331
has cross-reference: Drug_Central:1725
has cross-reference: FooDB:FDB022739
has cross-reference: HMDB:HMDB0001921
has cross-reference: KEGG:C07151
has cross-reference: KEGG:D04966
has cross-reference: LINCS:LSM-4730
has cross-reference: PDBeChem:MF8
has cross-reference: PMID:10900588
has cross-reference: PMID:10983737
has cross-reference: PMID:10999803
has cross-reference: PMID:11012555
has cross-reference: PMID:11126815
has cross-reference: PMID:11192132
has cross-reference: PMID:11257323
has cross-reference: PMID:11544610
has cross-reference: PMID:11772907
has cross-reference: PMID:12086935
has cross-reference: PMID:12406042
has cross-reference: PMID:12436333
has cross-reference: PMID:12630933
has cross-reference: PMID:12909816
has cross-reference: PMID:15261814
has cross-reference: PMID:15606381
has cross-reference: PMID:15650645
has cross-reference: PMID:15717887
has cross-reference: PMID:15932841
has cross-reference: PMID:16294070
has cross-reference: PMID:16520442
has cross-reference: PMID:16941277
has cross-reference: PMID:17062558
has cross-reference: PMID:18212742
has cross-reference: PMID:18608522
has cross-reference: PMID:23077661
has cross-reference: PMID:23540700
has cross-reference: PMID:24428821
has cross-reference: PMID:28919040
has cross-reference: PMID:31208831
has cross-reference: PMID:33191721
has cross-reference: Reaxys:606492
has cross-reference: Wikipedia:Metformin
alternative_term: N,N-dimethyltriimidodicarbonic diamide
has_obo_namespace: chebi_ontology
has_related_synonym: 1,1-dimethylbiguanide
has_related_synonym: LA 6023
has_related_synonym: LA-6023
has_related_synonym: N(1),N(1)-dimethylbiguanide
has_related_synonym: N,N-dimethylbiguanide
has_related_synonym: N,N-dimethyldiguanide
has_related_synonym: N,N-dimethylguanylguanidine
has_related_synonym: N,N-dimethylimidodicarbonimidic diamide
has_related_synonym: dimethylbiguanide
has_related_synonym: dimethyldiguanide
has_related_synonym: metformin
has_related_synonym: metformina
has_related_synonym: metformine
has_related_synonym: metforminum
id: CHEBI:6801
in subset: 3 STAR

mTOR inhibitor
type: Class
subclass of: protein kinase inhibitor
textual definition: A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.
imported from: chebi.owl
has cross-reference: Wikipedia:MTOR_inhibitors
has_obo_namespace: chebi_ontology
has_related_synonym: mTOR inhibitors
has_related_synonym: mammalian target of rapamycin inhibitor
has_related_synonym: mammalian target of rapamycin inhibitors
id: CHEBI:68481
in subset: 3 STAR

apoptosis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Type I cell-death inhibitor
has_related_synonym: Type I cell-death inhibitors
has_related_synonym: Type I programmed cell-death inhibitor
has_related_synonym: Type I programmed cell-death inhibitors
has_related_synonym: apoptosis inhibitors
id: CHEBI:68494
in subset: 3 STAR

apoptosis inducer
type: Class
subclass of: biochemical role
textual definition: Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Type I cell-death inducer
has_related_synonym: Type I cell-death inducers
has_related_synonym: Type I programmed cell-death inducer
has_related_synonym: Type I programmed cell-death inducers
has_related_synonym: apoptosis inducers
id: CHEBI:68495
in subset: 3 STAR

glutathione depleting agent
type: Class
subclass of: biological role
textual definition: A compound which causes a reduction in the levels of glutathione in cells.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glutathione depleting agents
has_related_synonym: glutathione depletion agent
has_related_synonym: glutathione depletion agents
has_related_synonym: glutathione depletor
has_related_synonym: glutathione depletors
id: CHEBI:68509
in subset: 3 STAR

EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor
type: Class
subclass of: EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor
textual definition: An EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor that interferes with the action of dihydroorotate oxidase (fumarate), EC 1.3.98.1 (formerly EC 1.3.3.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Dihydroorotate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-dihydroorotate:fumarate oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:fumarate oxidoreductase inhibitors
has_related_synonym: DHODH inhibitor
has_related_synonym: DHODH inhibitors
has_related_synonym: EC 1.3.3.1 inhibitor
has_related_synonym: EC 1.3.3.1 inhibitors
has_related_synonym: EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitor
has_related_synonym: EC 1.3.98.1 (dihydroorotate oxidase (fumarate)) inhibitors
has_related_synonym: EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitors
has_related_synonym: EC 1.3.98.1 inhibitor
has_related_synonym: EC 1.3.98.1 inhibitors
has_related_synonym: dihydroorotate dehydrogenase inhibitor
has_related_synonym: dihydroorotate dehydrogenase inhibitors
has_related_synonym: dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitor
has_related_synonym: dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitors
has_related_synonym: dihydroorotate oxidase (fumarate) inhibitor
has_related_synonym: dihydroorotate oxidase (fumarate) inhibitors
id: CHEBI:68542
in subset: 3 STAR

pyrimidine synthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: A pathway inhibitor that inhibits the synthesis of pyrimidine.
imported from: chebi.owl
has cross-reference: Wikipedia:Pyrimidine_metabolism
has_obo_namespace: chebi_ontology
has_related_synonym: pyrimidine synthesis inhibitors
id: CHEBI:68543
in subset: 3 STAR

guanylate cyclase 2C agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates guanylate cyclase 2C receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GC-C agonist
has_related_synonym: GC-C agonists
has_related_synonym: guanylate cyclase 2C agonists
id: CHEBI:68553
in subset: 3 STAR

bradykinin receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the bradykinin receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bradykinin receptor antagonists
id: CHEBI:68557
in subset: 3 STAR

P2Y12 receptor antagonist
type: Class
subclass of: purinergic receptor P2 antagonist
textual definition: An antagonist at the P2Y12 receptor
imported from: chebi.owl
has cross-reference: Wikipedia:P2Y12
has_obo_namespace: chebi_ontology
has_related_synonym: ADP receptor subtype P2Y12 antagonist
has_related_synonym: ADP receptor subtype P2Y12 antagonists
has_related_synonym: P2Y12 receptor antagonists
has_related_synonym: purinergic receptor subtype P2Y12 antagonist
has_related_synonym: purinergic receptor subtype P2Y12 antagonists
id: CHEBI:68563
in subset: 3 STAR

EC 3.4.21.6 (coagulation factor Xa) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of coagulation factor Xa (EC 3.4.21.6).
imported from: chebi.owl
has cross-reference: Wikipedia:Factor_Xa_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.6 (coagulation factor Xa) inhibitors
has_related_synonym: EC 3.4.21.6 inhibitor
has_related_synonym: EC 3.4.21.6 inhibitors
has_related_synonym: Stuart factor inhibitor
has_related_synonym: Stuart factor inhibitors
has_related_synonym: activated Stuart-Prower factor inhibitor
has_related_synonym: activated Stuart-Prower factor inhibitors
has_related_synonym: activated blood-coagulation factor X inhibitor
has_related_synonym: activated blood-coagulation factor X inhibitors
has_related_synonym: activated factor X inhibitor
has_related_synonym: activated factor X inhibitors
has_related_synonym: autoprothrombin C inhibitor
has_related_synonym: autoprothrombin C inhibitors
has_related_synonym: coagulation factor Xa (EC 3.4.21.6) inhibitor
has_related_synonym: coagulation factor Xa (EC 3.4.21.6) inhibitors
has_related_synonym: coagulation factor Xa inhibitor
has_related_synonym: coagulation factor Xa inhibitors
has_related_synonym: factor Xa inhibitor
has_related_synonym: factor Xa inhibitors
has_related_synonym: plasma thromboplastin inhibitor
has_related_synonym: plasma thromboplastin inhibitors
has_related_synonym: prothrombase inhibitor
has_related_synonym: prothrombase inhibitors
has_related_synonym: prothrombinase inhibitor
has_related_synonym: prothrombinase inhibitors
has_related_synonym: thrombokinase inhibitor
has_related_synonym: thrombokinase inhibitors
has_related_synonym: thromboplastin inhibitor
has_related_synonym: thromboplastin inhibitors
id: CHEBI:68581
in subset: 3 STAR

EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor
type: Class
subclass of: EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor
textual definition: An EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor that specifically inhibits dipeptidyl peptidase-4 (EC 3.4.14.5).
imported from: chebi.owl
has_alternative_id: CHEBI:76927
has cross-reference: Wikipedia:Dipeptidyl_peptidase-4_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: DPP IV/CD26 inhibitor
has_related_synonym: DPP IV/CD26 inhibitors
has_related_synonym: DPP-4 inhibitor
has_related_synonym: DPP-4 inhibitors
has_related_synonym: EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitors
has_related_synonym: EC 3.4.14.5 inhibitor
has_related_synonym: EC 3.4.14.5 inhibitors
has_related_synonym: Gly-Pro naphthylamidase inhibitor
has_related_synonym: Gly-Pro naphthylamidase inhibitors
has_related_synonym: T cell triggering molecule Tp103 inhibitor
has_related_synonym: T cell triggering molecule Tp103 inhibitors
has_related_synonym: X-PDAP inhibitor
has_related_synonym: X-PDAP inhibitors
has_related_synonym: X-prolyl dipeptidyl aminopeptidase inhibitor
has_related_synonym: X-prolyl dipeptidyl aminopeptidase inhibitors
has_related_synonym: Xaa-Pro-dipeptidyl-aminopeptidase inhibitor
has_related_synonym: Xaa-Pro-dipeptidyl-aminopeptidase inhibitors
has_related_synonym: amino acyl-prolyl dipeptidyl aminopeptidase inhibitor
has_related_synonym: amino acyl-prolyl dipeptidyl aminopeptidase inhibitors
has_related_synonym: dipeptidyl aminopeptidase IV inhibitor
has_related_synonym: dipeptidyl aminopeptidase IV inhibitors
has_related_synonym: dipeptidyl peptidase IV inhibitor
has_related_synonym: dipeptidyl peptidase IV inhibitors
has_related_synonym: dipeptidyl peptidase-4 inhibitors
has_related_synonym: dipeptidyl-aminopeptidase IV inhibitor
has_related_synonym: dipeptidyl-aminopeptidase IV inhibitors
has_related_synonym: dipeptidyl-peptidase IV (EC 3.4.14.5) inhibitor
has_related_synonym: dipeptidyl-peptidase IV (EC 3.4.14.5) inhibitors
has_related_synonym: dipeptidyl-peptidase IV inhibitor
has_related_synonym: dipeptidyl-peptidase IV inhibitors
has_related_synonym: dipeptidyl-peptide hydrolase inhibitor
has_related_synonym: dipeptidyl-peptide hydrolase inhibitors
has_related_synonym: glycoprotein GP110 inhibitor
has_related_synonym: glycoprotein GP110 inhibitors
has_related_synonym: glycylproline aminopeptidase inhibitor
has_related_synonym: glycylproline aminopeptidase inhibitors
has_related_synonym: glycylprolyl aminopeptidase inhibitor
has_related_synonym: glycylprolyl aminopeptidase inhibitors
has_related_synonym: glycylprolyl dipeptidylaminopeptidase inhibitor
has_related_synonym: glycylprolyl dipeptidylaminopeptidase inhibitors
has_related_synonym: leukocyte antigen CD26 inhibitor
has_related_synonym: leukocyte antigen CD26 inhibitors
has_related_synonym: lymphocyte antigen CD26 inhibitor
has_related_synonym: lymphocyte antigen CD26 inhibitors
has_related_synonym: pep X inhibitor
has_related_synonym: pep X inhibitors
has_related_synonym: postproline dipeptidyl aminopeptidase IV inhibitor
has_related_synonym: postproline dipeptidyl aminopeptidase IV inhibitors
id: CHEBI:68612
in subset: 3 STAR

EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of cytochrome P450 17-alpha-hydroxylase/C17,20-lyase (EC 1.14.99.9).
imported from: chebi.owl
has cross-reference: Wikipedia:CYP17A1
has_obo_namespace: chebi_ontology
has_related_synonym: 17-alpha-hydroxylase/C17,20-lyase inhibitor
has_related_synonym: 17-alpha-hydroxylase/C17,20-lyase inhibitors
has_related_synonym: 17alpha-hydroxylase-C17,20 lyase inhibitor
has_related_synonym: 17alpha-hydroxylase-C17,20 lyase inhibitors
has_related_synonym: CYP17 inhibitor
has_related_synonym: CYP17 inhibitors
has_related_synonym: CYP17A1 inhibitor
has_related_synonym: CYP17A1 inhibitors
has_related_synonym: EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitors
has_related_synonym: EC 1.14.99.9 inhibitor
has_related_synonym: EC 1.14.99.9 inhibitors
has_related_synonym: cytochrome P-45017alpha inhibitor
has_related_synonym: cytochrome P-45017alpha inhibitors
has_related_synonym: cytochrome P450 (P-45017alpha,lyase) inhibitor
has_related_synonym: cytochrome P450 (P-45017alpha,lyase) inhibitors
has_related_synonym: cytochrome P450 17-alpha-hydroxylase/C17,20-lyase inhibitor
has_related_synonym: cytochrome P450 17-alpha-hydroxylase/C17,20-lyase inhibitors
has_related_synonym: cytochrome p450 XVIIA1 inhibitor
has_related_synonym: cytochrome p450 XVIIA1 inhibitors
has_related_synonym: steroid 17alpha-hydroxylase inhibitor
has_related_synonym: steroid 17alpha-hydroxylase inhibitors
has_related_synonym: steroid 17alpha-monooxygenase (EC 1.14.99.9) inhibitor
has_related_synonym: steroid 17alpha-monooxygenase (EC 1.14.99.9) inhibitors
has_related_synonym: steroid 17alpha-monooxygenase inhibitor
has_related_synonym: steroid 17alpha-monooxygenase inhibitors
has_related_synonym: steroid 17alphahydroxylase/17,20 lyase inhibitor
has_related_synonym: steroid 17alphahydroxylase/17,20 lyase inhibitors
has_related_synonym: steroid,NADPH--hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating) inhibitor
has_related_synonym: steroid,NADPH--hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating) inhibitors
id: CHEBI:68640
in subset: 3 STAR

phosphodiesterase IV inhibitor
type: Class
subclass of: EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor
textual definition: An EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor that specifically blocks the action of phosphodiesterase IV.
imported from: chebi.owl
has cross-reference: Wikipedia:Phosphodiesterase-4_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: PDE4 inhibitor
has_related_synonym: PDE4 inhibitors
has_related_synonym: phosphodiesterase 4 inhibitor
has_related_synonym: phosphodiesterase 4 inhibitors
has_related_synonym: phosphodiesterase IV inhibitors
has_related_synonym: type 4 phosphodiesterase inhibitor
has_related_synonym: type 4 phosphodiesterase inhibitors
id: CHEBI:68844
in subset: 3 STAR

midazolam
type: Class
subclass of: molecular entity
textual definition: An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
imported from: chebi.owl
charge: 0
formula: C18H13ClFN3
inchi: InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
inchikey: DDLIGBOFAVUZHB-UHFFFAOYSA-N
mass: 325.768
monoisotopicmass: 325.07820
has cross-reference: CAS:59467-70-8
has cross-reference: DrugBank:DB00683
has cross-reference: Drug_Central:1802
has cross-reference: HMDB:HMDB0014821
has cross-reference: KEGG:C07524
has cross-reference: KEGG:D00550
has cross-reference: LINCS:LSM-5200
has cross-reference: MetaCyc:CPD-20500
has cross-reference: PDBeChem:08J
has cross-reference: PMID:1832310
has cross-reference: PMID:26032507
has cross-reference: PMID:28706559
has cross-reference: PMID:29516686
has cross-reference: PMID:30076807
has cross-reference: PMID:30113394
has cross-reference: PMID:30157038
has cross-reference: Reaxys:625572
has cross-reference: Wikipedia:Midazolam
alternative_term: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
has_obo_namespace: chebi_ontology
has_related_synonym: Buccolam
has_related_synonym: Dormicum
has_related_synonym: mezolam
has_related_synonym: midazolam
has_related_synonym: midazolamum
id: CHEBI:6931
in subset: 3 STAR

progesterone receptor agonist
type: Class
subclass of: hormone agonist
textual definition: A hormone agonist that binds to and activates progesterone receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: PR agonist
has_related_synonym: PR agonists
has_related_synonym: progesterone receptor agonists
id: CHEBI:70709
in subset: 3 STAR

EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor
type: Class
subclass of: EC 6.4.1.* (carboxylase) inhibitor
textual definition: An EC 6.4.1.* (C-C bond-forming ligase) inhibitor that interferes with the action of acetyl-CoA carboxylase (EC 6.4.1.2).
imported from: chebi.owl
has cross-reference: PMID:19552511
has cross-reference: PMID:22560583
has cross-reference: PMID:22677317
has cross-reference: Patent:US2009270435
has cross-reference: Wikipedia:Acetyl_CoA_carboxylase
has_obo_namespace: chebi_ontology
has_related_synonym: ACC inhibitor
has_related_synonym: ACC inhibitors
has_related_synonym: ACCase inhibitor
has_related_synonym: ACCase inhibitors
has_related_synonym: EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitors
has_related_synonym: EC 6.4.1.2 inhibitor
has_related_synonym: EC 6.4.1.2 inhibitors
has_related_synonym: acetyl coenzyme A carboxylase inhibitor
has_related_synonym: acetyl coenzyme A carboxylase inhibitors
has_related_synonym: acetyl-CoA carboxylase (EC 6.4.1.2) inhibitor
has_related_synonym: acetyl-CoA carboxylase (EC 6.4.1.2) inhibitors
has_related_synonym: acetyl-CoA carboxylase inhibitor
has_related_synonym: acetyl-CoA carboxylase inhibitors
has_related_synonym: acetyl-CoA:carbon-dioxide ligase (ADP-forming) inhibitor
has_related_synonym: acetyl-CoA:carbon-dioxide ligase (ADP-forming) inhibitors
id: CHEBI:70722
in subset: 3 STAR

cell dedifferentiation agent
type: Class
subclass of: biochemical role
textual definition: Any compound which induces a partially or terminally differentiated cell to revert to an earlier developmental stage.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cell dedifferentiation agents
id: CHEBI:70724
in subset: 3 STAR

adenosine A3 receptor antagonist
type: Class
subclass of: adenosine receptor antagonist
textual definition: An antagonist at the A3 receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_A3_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine A3 receptor antagonistS
id: CHEBI:70725
in subset: 3 STAR

topoisomerase inhibitor
type: Class
subclass of: EC 5.99.1.* (miscellaneous isomerase) inhibitor
textual definition: An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
imported from: chebi.owl
has cross-reference: Wikipedia:Topoisomerase
has_obo_namespace: chebi_ontology
has_related_synonym: topoisomerase inhibitors
id: CHEBI:70727
in subset: 3 STAR

actin polymerisation inhibitor
type: Class
subclass of: inhibitor
textual definition: Any substance that inhibits the polymerisation of the protein actin.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: actin polymerisation inhibitors
has_related_synonym: actin polymerization inhibitor
has_related_synonym: actin polymerization inhibitors
has_related_synonym: inhibitor of actin polymerization
has_related_synonym: inhibitors of actin polymerization
id: CHEBI:70728
in subset: 3 STAR

Aurora kinase inhibitor
type: Class
subclass of: protein kinase inhibitor
textual definition: Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation).
imported from: chebi.owl
has cross-reference: PMID:19369091
has cross-reference: PMID:21147253
has cross-reference: PMID:22350019
has_obo_namespace: chebi_ontology
has_related_synonym: Aurora kinase inhibitors
id: CHEBI:70770
in subset: 3 STAR

capsaicin receptor antagonist
type: Class
subclass of: antagonist
textual definition: Any substance which blocks the painful sensation of heat caused by capsaicin acting on the TRPV1 ion channel.
imported from: chebi.owl
has cross-reference: Wikipedia:Discovery_and_development_of_TRPV1_antagonists
has_obo_namespace: chebi_ontology
has_related_synonym: TRPV1 antagonist
has_related_synonym: TRPV1 antagonists
has_related_synonym: TrpV1 antagonist
has_related_synonym: TrpV1 antagonists
has_related_synonym: capsaicin antagonist
has_related_synonym: capsaicin antagonists
has_related_synonym: capsaicin receptor antagonists
has_related_synonym: transient receptor potential cation channel subfamily V member 1 antagonist
has_related_synonym: transient receptor potential cation channel subfamily V member 1 antagonists
has_related_synonym: vanilloid receptor 1 antagonist
has_related_synonym: vanilloid receptor 1 antagonists
id: CHEBI:70774
in subset: 3 STAR

PPAR modulator
type: Class
subclass of: pharmacological role
textual definition: Any compound which acts on the peroxisome proliferator-activated receptor.
imported from: chebi.owl
has cross-reference: PMID:18566691
has cross-reference: PMID:19746174
has cross-reference: Wikipedia:Peroxisome_proliferator-activated_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: PPAR modulators
has_related_synonym: peroxisome proliferator-activated receptor modulator
has_related_synonym: peroxisome proliferator-activated receptor modulators
id: CHEBI:70781
in subset: 3 STAR

PPARalpha agonist
type: Class
subclass of: agonist
subclass of: PPAR modulator
textual definition: A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha.
imported from: chebi.owl
has cross-reference: Wikipedia:Peroxisome_proliferator-activated_receptor_alpha
alternative_term: PPARalpha agonist
has_obo_namespace: chebi_ontology
has_related_synonym: PPAR-alpha agonist
has_related_synonym: PPAR-alpha agonists
has_related_synonym: PPARalpha agonists
has_related_synonym: peroxisome proliferator-activated receptor-alpha agonist
has_related_synonym: peroxisome proliferator-activated receptor-alpha agonists
id: CHEBI:70782
in subset: 3 STAR

EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitor
type: Class
subclass of: EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12).
imported from: chebi.owl
has cross-reference: Wikipedia:Glyceraldehyde-3-phosphate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: 3-phosphoglyceraldehyde dehydrogenase inhibitor
has_related_synonym: 3-phosphoglyceraldehyde dehydrogenase inhibitors
has_related_synonym: D-glyceraldehyde-3-phosphate:NAD(+) oxidoreductase (phosphorylating) inhibitor
has_related_synonym: D-glyceraldehyde-3-phosphate:NAD(+) oxidoreductase (phosphorylating) inhibitors
has_related_synonym: EC 1.2.1.12 (glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)) inhibitor
has_related_synonym: EC 1.2.1.12 (glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)) inhibitors
has_related_synonym: EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitors
has_related_synonym: EC 1.2.1.12 inhibitor
has_related_synonym: EC 1.2.1.12 inhibitors
has_related_synonym: GAPDH inhibitor
has_related_synonym: GAPDH inhibitors
has_related_synonym: NAD-dependent glyceraldehyde phosphate dehydrogenase inhibitor
has_related_synonym: NAD-dependent glyceraldehyde phosphate dehydrogenase inhibitors
has_related_synonym: NADH-glyceraldehyde phosphate dehydrogenase inhibitor
has_related_synonym: NADH-glyceraldehyde phosphate dehydrogenase inhibitors
has_related_synonym: dehydrogenase, glyceraldehyde phosphate inhibitor
has_related_synonym: dehydrogenase, glyceraldehyde phosphate inhibitors
has_related_synonym: glyceraldehyde phosphate dehydrogenase (NAD) inhibitor
has_related_synonym: glyceraldehyde phosphate dehydrogenase (NAD) inhibitors
has_related_synonym: glyceraldehyde-3-P-dehydrogenase inhibitor
has_related_synonym: glyceraldehyde-3-P-dehydrogenase inhibitors
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase (NAD) inhibitor
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase (NAD) inhibitors
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) inhibitor
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) inhibitors
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) inhibitor
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) inhibitors
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase inhibitor
has_related_synonym: glyceraldehyde-3-phosphate dehydrogenase inhibitors
has_related_synonym: phosphoglyceraldehyde dehydrogenase inhibitor
has_related_synonym: phosphoglyceraldehyde dehydrogenase inhibitors
has_related_synonym: triosephosphate dehydrogenase inhibitor
has_related_synonym: triosephosphate dehydrogenase inhibitors
id: CHEBI:70817
in subset: 3 STAR

cathepsin L (EC 3.4.22.15) inhibitor
type: Class
subclass of: cysteine protease inhibitor
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: An EC 3.4.22.* (cysteine endopeptidase) inhibitor which interferes with the action of cathepsin L (EC 3.4.22.15).
imported from: chebi.owl
has cross-reference: Wikipedia:Cathepsin_L
alternative_term: cathepsin L (EC 3.4.22.15) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: Aldrichina grahami cysteine proteinase inhibitor
has_related_synonym: Aldrichina grahami cysteine proteinase inhibitors
has_related_synonym: EC 3.4.22.15 inhibitor
has_related_synonym: EC 3.4.22.15 inhibitors
has_related_synonym: cathepsin L (EC 3.4.22.15) inhibitors
has_related_synonym: cathepsin L inhibitor
has_related_synonym: cathepsin L inhibitors
has_related_synonym: cathepsin L1 inhibitor
has_related_synonym: cathepsin L1 inhibitors
id: CHEBI:70821
in subset: 3 STAR

EC 3.4.22.2 (papain) inhibitor
type: Class
subclass of: cysteine protease inhibitor
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: A cysteine protease inhibitor which inhibits papain (EC 3.4.22.2).
imported from: chebi.owl
alternative_term: EC 3.4.22.2 (papain) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.22.2 inhibitor
has_related_synonym: EC 3.4.22.2 inhibitors
has_related_synonym: papain (EC 3.4.22.2) inhibitor
has_related_synonym: papain (EC 3.4.22.2) inhibitors
has_related_synonym: papain inhibitor
has_related_synonym: papain inhibitors
has_related_synonym: papaine inhibitor
has_related_synonym: papaine inhibitors
has_related_synonym: papaya peptidase I inhibitor
has_related_synonym: papaya peptidase I inhibitors
has_related_synonym: papayotin inhibitor
has_related_synonym: papayotin inhibitors
has_related_synonym: summetrin inhibitor
has_related_synonym: summetrin inhibitors
has_related_synonym: velardon inhibitor
has_related_synonym: velardon inhibitors
id: CHEBI:70822
in subset: 3 STAR

antileishmanial agent
type: Class
subclass of: antiprotozoal drug
textual definition: An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antileishmanial agents
has_related_synonym: antileishmanial drug
has_related_synonym: antileishmanial drugs
id: CHEBI:70868
in subset: 3 STAR

reactive oxygen species generator
type: Class
subclass of: chemical role
textual definition: Any entity used to generate reactive oxygen species.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ROS generator
has_related_synonym: ROS generators
has_related_synonym: reactive oxygen species generators
id: CHEBI:70982
in subset: 3 STAR

G-protein-coupled receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates G-protein-coupled receptors
imported from: chebi.owl
has cross-reference: Wikipedia:G_protein-coupled_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: G-protein-coupled receptor agonists
has_related_synonym: GPCR agonist
has_related_synonym: GPCR agonists
id: CHEBI:70998
in subset: 3 STAR

AMPA receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the AMPA receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:AMPA_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: AMPA receptor antagonists
has_related_synonym: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist
has_related_synonym: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists
id: CHEBI:71014
in subset: 3 STAR

progesterone receptor modulator
type: Class
subclass of: hormone receptor modulator
textual definition: A hormone receptor modulator that acts as a complete or partial agonist or as an antagonist at the progesterone receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Selective_progesterone_receptor_modulator
has_obo_namespace: chebi_ontology
has_related_synonym: progesterone receptor modulators
id: CHEBI:71027
in subset: 3 STAR

orphan drug
type: Class
subclass of: drug
textual definition: Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
imported from: chebi.owl
has cross-reference: PMID:20036435
has cross-reference: PMID:20800761
has cross-reference: PMID:21180460
has cross-reference: PMID:21682893
has cross-reference: PMID:21947805
has cross-reference: PMID:22363762
has cross-reference: PMID:22366309
has cross-reference: PMID:22371464
has cross-reference: PMID:22731105
has cross-reference: PMID:22739138
has cross-reference: PMID:22747423
has cross-reference: PMID:22814659
has cross-reference: PMID:22814660
has cross-reference: PMID:22973866
has cross-reference: PMID:22981668
has cross-reference: PMID:22989856
has cross-reference: PMID:23013790
has cross-reference: PMID:23090701
has cross-reference: PMID:23109143
has cross-reference: PMID:23129684
has cross-reference: Wikipedia:Orphan_drug
has_obo_namespace: chebi_ontology
has_related_synonym: orphan drugs
id: CHEBI:71031
in subset: 3 STAR

carbamylphosphate synthetase I activator
type: Class
subclass of: enzyme activator
textual definition: Any compound that binds and activates the enzyme carbamylphosphate synthetase I.
imported from: chebi.owl
has cross-reference: Wikipedia:Carbamoyl_phosphate_synthetase_I
has_obo_namespace: chebi_ontology
has_related_synonym: carbamylphosphate synthetase I activators
id: CHEBI:71033
in subset: 3 STAR

HIV-1 maturation inhibitor
type: Class
subclass of: inhibitor
subclass of: anti-HIV-1 agent
textual definition: A compound that blocks the processing of the Gag precursor protein in HIV-1 by the viral protease enzyme, leading to the formation of noninfectious, immature virus particles that are incapable of infecting other cells.
imported from: chebi.owl
has cross-reference: Wikipedia:Maturation_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: HIV-1 maturation inhibitors
id: CHEBI:71168
in subset: 3 STAR

H1-receptor agonist
type: Class
subclass of: histamine agonist
textual definition: A histamine agonist that binds to and activates H1-receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Histamine_H1_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: H1-receptor agonists
has_related_synonym: histamine H1-receptor agonist
has_related_synonym: histamine H1-receptor agonists
id: CHEBI:71173
in subset: 3 STAR

EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of N-acetylserotonin methyltransferase (EC 2.1.1.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Acetylserotonin_O-methyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: ASMT inhibitor
has_related_synonym: ASMT inhibitors
has_related_synonym: EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.4 inhibitor
has_related_synonym: EC 2.1.1.4 inhibitors
has_related_synonym: N-acetylserotonin O-methyltransferase inhibitor
has_related_synonym: N-acetylserotonin O-methyltransferase inhibitors
has_related_synonym: N-acetylserotonin methyltransferase inhibitor
has_related_synonym: N-acetylserotonin methyltransferase inhibitors
has_related_synonym: S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase inhibitor
has_related_synonym: S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase inhibitors
has_related_synonym: acetylserotonin O-methyltransferase (EC 2.1.1.4) inhibitor
has_related_synonym: acetylserotonin O-methyltransferase (EC 2.1.1.4) inhibitors
has_related_synonym: acetylserotonin O-methyltransferase inhibitor
has_related_synonym: acetylserotonin O-methyltransferase inhibitors
has_related_synonym: acetylserotonin methyltransferase inhibitor
has_related_synonym: acetylserotonin methyltransferase inhibitors
has_related_synonym: hydroxyindole O-methyltransferase inhibitor
has_related_synonym: hydroxyindole O-methyltransferase inhibitors
has_related_synonym: hydroxyindole methyltransferase inhibitor
has_related_synonym: hydroxyindole methyltransferase inhibitors
id: CHEBI:71178
in subset: 3 STAR

Sir2 inhibitor
type: Class
subclass of: EC 3.5.1.98 (histone deacetylase) inhibitor
textual definition: An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir2.
imported from: chebi.owl
has cross-reference: Wikipedia:Sir2
has_obo_namespace: chebi_ontology
has_related_synonym: Sir2 inhibitors
id: CHEBI:71181
in subset: 3 STAR

glucagon-like peptide-1 receptor agonist
type: Class
subclass of: G-protein-coupled receptor agonist
textual definition: An agonist that binds to and activates glucagon-like peptide-1 (GLP-1) receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:GLP-1_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: GLP-1 receptor agonist
has_related_synonym: GLP-1 receptor agonists
has_related_synonym: glucagon-like peptide-1 receptor agonists
id: CHEBI:71196
in subset: 3 STAR

prohormone
type: Class
subclass of: biological role
textual definition: Any intra-glandular substance that acts as a precursor of a hormone, usually having minimal hormonal effect itself. Prohormones generally help in amplifying the effect of existing hormones.
imported from: chebi.owl
has cross-reference: Wikipedia:Prohormone
has_obo_namespace: chebi_ontology
has_related_synonym: prohormones
id: CHEBI:71212
in subset: 3 STAR

adenosine receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at any adenosine receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine receptor antagonists
id: CHEBI:71232
in subset: 3 STAR

EC 2.* (transferase) inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)
imported from: chebi.owl
has cross-reference: Wikipedia:Transferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2 inhibitor
has_related_synonym: EC 2 inhibitors
has_related_synonym: EC 2.* (transferase) inhibitors
has_related_synonym: EC 2.* inhibitor
has_related_synonym: EC 2.* inhibitors
has_related_synonym: transferase inhibitor
has_related_synonym: transferase inhibitors
id: CHEBI:71300
in subset: 3 STAR

autoinducer
type: Class
subclass of: signalling molecule
textual definition: A signalling molecule produced and used by bacteria participating in quorum sensing, that is, in cell-cell communication to coordinate community-wide regulation of processes such as biofilm formation, virulence, and bioluminescence in populations of bacteria. Such communication can occur both within and between different species of bacteria.
imported from: chebi.owl
has cross-reference: Wikipedia:Autoinducer
has_obo_namespace: chebi_ontology
has_related_synonym: autoinducers
id: CHEBI:71338
in subset: 3 STAR

EC 2.3.1.85 (fatty acid synthase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of fatty acid synthase (EC 2.3.1.85), a multi-enzyme protein involved in fatty acid synthesis.
imported from: chebi.owl
has cross-reference: Wikipedia:Fatty-acid_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: (FAS) inhibitors
has_related_synonym: EC 2.3.1.85 (fatty acid synthase) inhibitors
has_related_synonym: EC 2.3.1.85 inhibitor
has_related_synonym: EC 2.3.1.85 inhibitors
has_related_synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitor
has_related_synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitors
has_related_synonym: fatty acid synthase (EC 2.3.1.85) inhibitor
has_related_synonym: fatty acid synthase (EC 2.3.1.85) inhibitors
has_related_synonym: fatty acid synthase inhibitor
has_related_synonym: fatty acid synthase inhibitors
id: CHEBI:71476
in subset: 3 STAR

EC 3.5.1.23 (ceramidase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of ceramidase (EC 3.5.1.23).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: AC inhibitor
has_related_synonym: AC inhibitors
has_related_synonym: EC 3.5.1.23 (ceramidase) inhibitors
has_related_synonym: EC 3.5.1.23 inhibitor
has_related_synonym: EC 3.5.1.23 inhibitors
has_related_synonym: N-acylsphingosine amidohydrolase inhibitor
has_related_synonym: N-acylsphingosine amidohydrolase inhibitors
has_related_synonym: acid ceramidase inhibitor
has_related_synonym: acid ceramidase inhibitors
has_related_synonym: acylsphingosine deacylase inhibitor
has_related_synonym: acylsphingosine deacylase inhibitors
has_related_synonym: ceramidase (EC 3.5.1.23) inhibitor
has_related_synonym: ceramidase (EC 3.5.1.23) inhibitors
has_related_synonym: ceramidase inhibitor
has_related_synonym: ceramidase inhibitors
has_related_synonym: glycosphingolipid ceramide deacylase inhibitor
has_related_synonym: glycosphingolipid ceramide deacylase inhibitors
id: CHEBI:71551
in subset: 3 STAR

PPARgamma agonist
type: Class
subclass of: agonist
subclass of: PPAR modulator
textual definition: A PPAR modulator which activates the peroxisome proliferator-activated receptor-gamma.
imported from: chebi.owl
has cross-reference: Wikipedia:Peroxisome_proliferator-activated_receptor_gamma
alternative_term: PPARgamma agonist
has_obo_namespace: chebi_ontology
has_related_synonym: PPAR-gamma agonist
has_related_synonym: PPAR-gamma agonists
has_related_synonym: PPARgamma agonists
has_related_synonym: peroxisome proliferator-activated receptor-gamma agonist
has_related_synonym: peroxisome proliferator-activated receptor-gamma agonists
id: CHEBI:71554
in subset: 3 STAR

insect repellent
type: Class
subclass of: insecticide
textual definition: An insecticide that acts as a repellent to insects.
imported from: chebi.owl
has cross-reference: Wikipedia:Insect_repellent
has_obo_namespace: chebi_ontology
has_related_synonym: insect repellents
id: CHEBI:71692
in subset: 3 STAR

EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor
type: Class
subclass of: EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
textual definition: An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that blocks the action of 3',5'-cyclic-GMP phosphodiesterase (EC 3.1.4.35).
imported from: chebi.owl
has cross-reference: PMID:22996758
has cross-reference: PMID:23343170
has cross-reference: PMID:23346948
has cross-reference: Wikipedia:CGMP-specific_phosphodiesterase_type_5
has cross-reference: Wikipedia:PDE5_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: 3',5'-cyclic-GMP 5'-nucleotidohydrolase inhibitor
has_related_synonym: 3',5'-cyclic-GMP 5'-nucleotidohydrolase inhibitors
has_related_synonym: 3',5'-cyclic-GMP phosphodiesterase (EC 3.1.4.35) inhibitor
has_related_synonym: 3',5'-cyclic-GMP phosphodiesterase (EC 3.1.4.35) inhibitors
has_related_synonym: EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitors
has_related_synonym: EC 3.1.4.35 inhibitor
has_related_synonym: EC 3.1.4.35 inhibitors
has_related_synonym: PDE5 inhibitor
has_related_synonym: PDE5 inhibitors
has_related_synonym: cGMP phosphodiesterase inhibitor
has_related_synonym: cGMP phosphodiesterase inhibitors
has_related_synonym: cGMP-PDE inhibitor
has_related_synonym: cGMP-PDE inhibitors
has_related_synonym: cyclic 3',5'-GMP phosphodiesterase inhibitor
has_related_synonym: cyclic 3',5'-GMP phosphodiesterase inhibitors
has_related_synonym: cyclic GMP phosphodiesterase inhibitor
has_related_synonym: cyclic GMP phosphodiesterase inhibitors
has_related_synonym: cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitor
has_related_synonym: cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors
has_related_synonym: cyclic guanosine 3',5'-phosphate phosphodiesterase inhibitor
has_related_synonym: cyclic guanosine 3',5'-phosphate phosphodiesterase inhibitors
has_related_synonym: guanosine cyclic 3',5'-phosphate phosphodiesterase inhibitor
has_related_synonym: guanosine cyclic 3',5'-phosphate phosphodiesterase inhibitors
has_related_synonym: phosphodiesterase 5 inhibitor
has_related_synonym: phosphodiesterase 5 inhibitors
has_related_synonym: phosphodiesterase V inhibitor
has_related_synonym: phosphodiesterase V inhibitors
has_related_synonym: type 5 phosphodiesterase inhibitor
has_related_synonym: type 5 phosphodiesterase inhibitors
id: CHEBI:71942
in subset: 3 STAR

EC 3.5.1.88 (peptide deformylase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of peptide deformylase (EC 3.5.1.88), involved in the catalytic removal of the N-terminal formyl group of nascent proteins.
imported from: chebi.owl
has cross-reference: Wikipedia:Peptide_deformylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.88 (peptide deformylase) inhibitors
has_related_synonym: EC 3.5.1.88 inhibitor
has_related_synonym: EC 3.5.1.88 inhibitors
has_related_synonym: PDF inhibitors
has_related_synonym: formyl-L-methionyl peptide amidohydrolase inhibitor
has_related_synonym: formyl-L-methionyl peptide amidohydrolase inhibitors
has_related_synonym: peptide deformylase (EC 3.5.1.88) inhibitor
has_related_synonym: peptide deformylase (EC 3.5.1.88) inhibitors
has_related_synonym: peptide deformylase inhibitor
has_related_synonym: peptide deformylase inhibitors
id: CHEBI:71951
in subset: 3 STAR

nerve growth factor stimulator
type: Class
subclass of: neurotransmitter agent
textual definition: Any molecule shown to have the potentiality in stimulating the effect of nerve growth factor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NGF stimulator
has_related_synonym: NGF stimulators
has_related_synonym: nerve growth factor stimulators
id: CHEBI:72294
in subset: 3 STAR

MTP inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: An inhibitor that interferes with the action of MTP.
imported from: chebi.owl
has cross-reference: Wikipedia:Microsomal_triglyceride_transfer_protein
has_obo_namespace: chebi_ontology
has_related_synonym: MTP inhibitors
has_related_synonym: MTTP inhibitor
has_related_synonym: MTTP inhibitors
has_related_synonym: microsomal triglyceride transfer protein inhibitor
has_related_synonym: microsomal triglyceride transfer protein inhibitors
id: CHEBI:72298
in subset: 3 STAR

glucagon-like peptide-2 receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates glucagon-like peptide-2 (GLP-2) receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Glucagon-like_peptide_2_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: GLP-2 receptor agonist
has_related_synonym: GLP-2 receptor agonists
has_related_synonym: glucagon-like peptide-2 receptor agonists
id: CHEBI:72311
in subset: 3 STAR

virulence factor
type: Class
subclass of: toxin
textual definition: Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host.
imported from: chebi.owl
has cross-reference: PMID:22851449
has cross-reference: Wikipedia:Virulence_factor
has_obo_namespace: chebi_ontology
has_related_synonym: virulence factors
id: CHEBI:72316
in subset: 3 STAR

provitamin B1
type: Class
subclass of: provitamin
textual definition: A provitamin that can be converted into vitamin B1 by enzymes from animal tissues.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: provitamin B1s
id: CHEBI:72470
in subset: 3 STAR

vesicular glutamate transport inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: An inhibitor that interferes with vesicular glutamate transport.
imported from: chebi.owl
has cross-reference: Wikipedia:Vesicular_glutamate_transporter_1
has_obo_namespace: chebi_ontology
has_related_synonym: vesicular glutamate transport inhibitors
has_related_synonym: vesicular glutamate transporter 1 inhibitor
has_related_synonym: vesicular glutamate transporter 1 inhibitors
id: CHEBI:72483
in subset: 3 STAR

pro-angiogenic agent
type: Class
subclass of: angiogenesis modulating agent
textual definition: Any compound that promotes the growth of new blood vessels from pre-existing vessels.
imported from: chebi.owl
has_alternative_id: CHEBI:50927
has_obo_namespace: chebi_ontology
has_related_synonym: angiogenesis inducing agent
has_related_synonym: angiogenesis inducing agents
has_related_synonym: pro-angiogenic agents
has_related_synonym: proangiogenic agent
has_related_synonym: proangiogenic agents
id: CHEBI:72571
in subset: 3 STAR

alarm pheromone
type: Class
subclass of: pheromone
textual definition: A pheromone which is released by an organism when damaged by a predator which warns other individuals that there is a danger.
imported from: chebi.owl
has cross-reference: PMID:20831948
has cross-reference: PMID:22870255
has_obo_namespace: chebi_ontology
has_related_synonym: alarm pheromones
has_related_synonym: alarm signal
has_related_synonym: alarm signals
has_related_synonym: alarm substance
has_related_synonym: alarm substances
id: CHEBI:72575
in subset: 3 STAR

EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor
type: Class
subclass of: EC 2.3.2.* (aminoacyltransferase) inhibitor
textual definition: An EC 2.3.2.* (aminoacyltransferase) inhibitor that interferes with the action of protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13).
imported from: chebi.owl
has cross-reference: Wikipedia:Transglutaminase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitors
has_related_synonym: EC 2.3.2.13 inhibitor
has_related_synonym: EC 2.3.2.13 inhibitors
has_related_synonym: Factor XIIIa inhibitor
has_related_synonym: R-glutaminyl-peptide:amine gamma-glutamyl transferase inhibitor
has_related_synonym: TG-2 inhibitor
has_related_synonym: TG-2 inhibitors
has_related_synonym: TG2 inhibitor
has_related_synonym: TG2 inhibitors
has_related_synonym: TGase inhibitor
has_related_synonym: TGase inhibitors
has_related_synonym: fibrin stabilizing factor inhibitor
has_related_synonym: fibrin stabilizing factor inhibitors
has_related_synonym: fibrinoligase inhibitor
has_related_synonym: fibrinoligase inhibitors
has_related_synonym: glutaminylpeptide gamma-glutamyltransferase inhibitor
has_related_synonym: glutaminylpeptide gamma-glutamyltransferase inhibitors
has_related_synonym: polyamine transglutaminase inhibitor
has_related_synonym: polyamine transglutaminase inhibitors
has_related_synonym: protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) inhibitor
has_related_synonym: protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) inhibitors
has_related_synonym: protein-glutamine gamma-glutamyltransferase inhibitor
has_related_synonym: protein-glutamine gamma-glutamyltransferase inhibitors
has_related_synonym: protein-glutamine:amine gamma-glutamyltransferase inhibitor
has_related_synonym: protein-glutamine:amine gamma-glutamyltransferase inhibitors
has_related_synonym: tissue transglutaminase inhibitor
has_related_synonym: tissue transglutaminase inhibitors
has_related_synonym: transglutaminase inhibitor
has_related_synonym: transglutaminase inhibitors
has_related_synonym: transglutaminase-2 inhibitor
has_related_synonym: transglutaminase-2 inhibitors
id: CHEBI:72716
in subset: 3 STAR

aryl hydrocarbon receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: AHR agonist
has_related_synonym: AHR agonists
has_related_synonym: AhR agonist
has_related_synonym: AhR agonists
has_related_synonym: aryl hydrocarbon receptor agonists
id: CHEBI:72768
in subset: 3 STAR

breast cancer resistance protein inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of breast cancer resistance protein (ABCG2).
imported from: chebi.owl
has cross-reference: Wikipedia:ABCG2
has_obo_namespace: chebi_ontology
has_related_synonym: ABCG2 inhibitor
has_related_synonym: ABCG2 inhibitors
has_related_synonym: breast cancer resistance protein inhibitors
id: CHEBI:72771
in subset: 3 STAR

carotogenesis inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor of the biosynthesis of carotenoids.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carotogenesis inhibitors
id: CHEBI:72773
in subset: 3 STAR

EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor
type: Class
subclass of: EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor
textual definition: An EC 1.3.99.* (oxidoreductase acting on donor CH-CH group with other acceptors) inhibitor that interferes with the action of phytoene desaturase (zeta-carotene-forming), EC 1.3.99.29, an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene (zeta-carotene) via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) inhibitor
has_related_synonym: 15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) inhibitors
has_related_synonym: 2-step phytoene desaturase inhibitor
has_related_synonym: 2-step phytoene desaturase inhibitors
has_related_synonym: CrtIa inhibitor
has_related_synonym: CrtIa inhibitors
has_related_synonym: EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitors
has_related_synonym: EC 1.3.99.29 inhibitor
has_related_synonym: EC 1.3.99.29 inhibitors
has_related_synonym: phytoene dehydrogenase inhibitor
has_related_synonym: phytoene dehydrogenase inhibitors
has_related_synonym: phytoene desaturase (zeta-carotene-forming) (EC 1.3.99.29) inhibitor
has_related_synonym: phytoene desaturase (zeta-carotene-forming) (EC 1.3.99.29) inhibitors
has_related_synonym: phytoene desaturase (zeta-carotene-forming) inhibitor
has_related_synonym: phytoene desaturase (zeta-carotene-forming) inhibitors
has_related_synonym: phytoene desaturase inhibitor
has_related_synonym: phytoene desaturase inhibitors
has_related_synonym: two-step phytoene desaturase inhibitor
has_related_synonym: two-step phytoene desaturase inhibitors
id: CHEBI:72774
in subset: 3 STAR

EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor
type: Class
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
textual definition: An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor that interferes with the action of indoleamine 2,3-dioxygenase (EC 1.13.11.52).
imported from: chebi.owl
has cross-reference: Wikipedia:Indoleamine_2,3-dioxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitor
has_related_synonym: D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) inhibitors
has_related_synonym: EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitors
has_related_synonym: EC 1.13.11.52 inhibitor
has_related_synonym: EC 1.13.11.52 inhibitors
has_related_synonym: IDO inhibitor
has_related_synonym: IDO inhibitors
has_related_synonym: indoleamine 2,3-dioxygenase (EC 1.13.11.52) inhibitor
has_related_synonym: indoleamine 2,3-dioxygenase (EC 1.13.11.52) inhibitors
has_related_synonym: indoleamine 2,3-dioxygenase inhibitor
has_related_synonym: indoleamine 2,3-dioxygenase inhibitors
id: CHEBI:72854
in subset: 3 STAR

EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of carbonyl reductase (NADPH), EC 1.1.1.184.
imported from: chebi.owl
has cross-reference: Wikipedia:Carbonyl_reductase_(NADPH)
has_obo_namespace: chebi_ontology
has_related_synonym: ALR3 inhibitor
has_related_synonym: ALR3 inhibitors
has_related_synonym: EC 1.1.1.184 (carbonyl reductase (NADPH)) inhibitor
has_related_synonym: EC 1.1.1.184 (carbonyl reductase (NADPH)) inhibitors
has_related_synonym: EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitors
has_related_synonym: EC 1.1.1.184 inhibitor
has_related_synonym: EC 1.1.1.184 inhibitors
has_related_synonym: NADPH2-dependent carbonyl reductase inhibitor
has_related_synonym: NADPH2-dependent carbonyl reductase inhibitors
has_related_synonym: aldehyde reductase 1 inhibitor
has_related_synonym: aldehyde reductase 1 inhibitors
has_related_synonym: carbonyl reductase (NADPH) (EC 1.1.1.184) inhibitor
has_related_synonym: carbonyl reductase (NADPH) (EC 1.1.1.184) inhibitors
has_related_synonym: carbonyl reductase (NADPH) inhibitor
has_related_synonym: carbonyl reductase (NADPH) inhibitors
has_related_synonym: carbonyl reductase (NADPH2) inhibitor
has_related_synonym: carbonyl reductase (NADPH2) inhibitors
has_related_synonym: carbonyl reductase inhibitor
has_related_synonym: carbonyl reductase inhibitors
has_related_synonym: nonspecific NADPH-dependent carbonyl reductase inhibitor
has_related_synonym: nonspecific NADPH-dependent carbonyl reductase inhibitors
has_related_synonym: prostaglandin 9-ketoreductase inhibitor
has_related_synonym: prostaglandin 9-ketoreductase inhibitors
has_related_synonym: secondary-alcohol:NADP+ oxidoreductase inhibitor
has_related_synonym: secondary-alcohol:NADP+ oxidoreductase inhibitors
has_related_synonym: xenobiotic ketone reductase inhibitor
has_related_synonym: xenobiotic ketone reductase inhibitors
id: CHEBI:73136
in subset: 3 STAR

EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor
type: Class
subclass of: EC 1.11.1.* (peroxidases) inhibitor
textual definition: An EC 1.11.1.* (peroxidases) inhibitor that inhibits the action of L-ascorbate peroxidase (EC 1.11.1.11).
imported from: chebi.owl
has cross-reference: Wikipedia:L-ascorbate_peroxidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.11.1.11 (L-ascorbate peroxidase) inhibitors
has_related_synonym: EC 1.11.1.11 inhibitor
has_related_synonym: EC 1.11.1.11 inhibitors
has_related_synonym: L-ascorbate peroxidase (EC 1.11.1.11) inhibitor
has_related_synonym: L-ascorbate peroxidase (EC 1.11.1.11) inhibitors
has_related_synonym: L-ascorbate peroxidase inhibitor
has_related_synonym: L-ascorbate peroxidase inhibitors
has_related_synonym: L-ascorbate:hydrogen-peroxide oxidoreductase inhibitor
has_related_synonym: L-ascorbate:hydrogen-peroxide oxidoreductase inhibitors
has_related_synonym: L-ascorbic acid peroxidase inhibitor
has_related_synonym: L-ascorbic acid peroxidase inhibitors
has_related_synonym: L-ascorbic acid-specific peroxidase inhibitor
has_related_synonym: L-ascorbic acid-specific peroxidase inhibitors
has_related_synonym: ascorbate peroxidase inhibitor
has_related_synonym: ascorbate peroxidase inhibitors
has_related_synonym: ascorbic acid peroxidase inhibitor
has_related_synonym: ascorbic acid peroxidase inhibitors
id: CHEBI:73181
in subset: 3 STAR

plant activator
type: Class
subclass of: agrochemical
textual definition: Any compound that protects plants by activating their defence mechanisms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: plant activators
id: CHEBI:73182
in subset: 3 STAR

brassinosteroid biosynthesis inhibitor
type: Class
subclass of: inhibitor
textual definition: Any compound that inhibits one or more steps in the pathway leading to the synthesis of brassinosteroids.
imported from: chebi.owl
has cross-reference: PMID:10462767
has_obo_namespace: chebi_ontology
has_related_synonym: brassinosteroid biosynthesis inhibitors
id: CHEBI:73189
in subset: 3 STAR

antimutagen
type: Class
subclass of: biological role
textual definition: An agent that reduces or interferes with the mutagenic actions or effects of a substance.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antimutagenic agent
has_related_synonym: antimutagenic agents
has_related_synonym: antimutagens
id: CHEBI:73190
in subset: 3 STAR

abscisic acid receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates abscisic acid receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ABA agonist
has_related_synonym: ABA agonists
has_related_synonym: ABA receptor agonist
has_related_synonym: ABA receptor agonists
has_related_synonym: abscisic acid receptor agonists
id: CHEBI:73191
in subset: 3 STAR

EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor
type: Class
subclass of: EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitor
textual definition: An EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitor that interferes with the action of protoporphyrinogen oxidase (EC 1.3.3.4).
imported from: chebi.owl
has cross-reference: PMID:15660355
has cross-reference: PMID:22273380
has cross-reference: Wikipedia:Protoporphyrinogen_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitors
has_related_synonym: EC 1.3.3.4 inhibitor
has_related_synonym: EC 1.3.3.4 inhibitors
has_related_synonym: HemG inhibitor
has_related_synonym: HemG inhibitors
has_related_synonym: HemY inhibitor
has_related_synonym: HemY inhibitors
has_related_synonym: PPO inhibitor
has_related_synonym: PPO inhibitors
has_related_synonym: Protox inhibitor
has_related_synonym: Protox inhibitors
has_related_synonym: protoporphyrinogen IX oxidase inhibitor
has_related_synonym: protoporphyrinogen IX oxidase inhibitors
has_related_synonym: protoporphyrinogen oxidase (EC 1.3.3.4) inhibitor
has_related_synonym: protoporphyrinogen oxidase (EC 1.3.3.4) inhibitors
has_related_synonym: protoporphyrinogen oxidase inhibitor
has_related_synonym: protoporphyrinogen oxidase inhibitors
has_related_synonym: protoporphyrinogen-IX:oxygen oxidoreductase inhibitor
has_related_synonym: protoporphyrinogen-IX:oxygen oxidoreductase inhibitors
has_related_synonym: protoporphyrinogenase inhibitor
has_related_synonym: protoporphyrinogenase inhibitors
id: CHEBI:73192
in subset: 3 STAR

gibberellin biosynthesis inhibitor
type: Class
subclass of: inhibitor
textual definition: Any compound that inhibits one or more steps in the pathway leading to the synthesis of gibberellins.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: gibberellin biosynthesis inhibitors
id: CHEBI:73193
in subset: 3 STAR

EC 4.4.1.11 (methionine gamma-lyase) inhibitor
type: Class
subclass of: EC 4.4.1.* (C-S lyase) inhibitor
textual definition: An EC 4.4.1.* (C-S lyase) inhibitor that interferes with the action of the enzyme methionine gamma-lyase (EC 4.4.1.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Methionine_gamma-lyase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.4.1.11 (methionine gamma-lyase) inhibitors
has_related_synonym: L-methioninase inhibitor
has_related_synonym: L-methioninase inhibitors
has_related_synonym: methioninase inhibitor
has_related_synonym: methioninase inhibitors
has_related_synonym: methionine gamma-lyase (EC 4.4.1.11) inhibitor
has_related_synonym: methionine gamma-lyase (EC 4.4.1.11) inhibitors
has_related_synonym: methionine gamma-lyase inhibitor
has_related_synonym: methionine gamma-lyase inhibitors
id: CHEBI:73196
in subset: 3 STAR

EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
textual definition: An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of H(+)-transporting two-sector ATPase inhibitor (EC 3.6.3.14).
imported from: chebi.owl
has cross-reference: Wikipedia:ATP_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP phosphohydrolase (H(+)-transporting) inhibitor
has_related_synonym: ATP phosphohydrolase (H(+)-transporting) inhibitors
has_related_synonym: ATP synthase inhibitor
has_related_synonym: ATP synthase inhibitors
has_related_synonym: EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitors
has_related_synonym: EC 3.6.3.14 inhibitor
has_related_synonym: EC 3.6.3.14 inhibitors
has_related_synonym: F1-ATPase inhibitor
has_related_synonym: F1-ATPase inhibitors
has_related_synonym: FoF1-ATPase inhibitor
has_related_synonym: FoF1-ATPase inhibitors
has_related_synonym: H(+)-transporting ATPase inhibitor
has_related_synonym: H(+)-transporting ATPase inhibitors
has_related_synonym: H(+)-transporting two-sector ATPase (EC 3.6.3.14) inhibitor
has_related_synonym: H(+)-transporting two-sector ATPase (EC 3.6.3.14) inhibitors
has_related_synonym: H(+)-transporting two-sector ATPase inhibitor
has_related_synonym: H(+)-transporting two-sector ATPase inhibitors
has_related_synonym: bacterial Ca(2+)/Mg(2+) ATPase inhibitor
has_related_synonym: bacterial Ca(2+)/Mg(2+) ATPase inhibitors
has_related_synonym: chloroplast ATPase inhibitor
has_related_synonym: chloroplast ATPase inhibitors
has_related_synonym: coupling factors (Fo, F1 and CF1) inhibitor
has_related_synonym: coupling factors (Fo, F1 and CF1) inhibitors
has_related_synonym: mitochondrial ATPase inhibitor
has_related_synonym: mitochondrial ATPase inhibitors
id: CHEBI:73214
in subset: 3 STAR

EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase which acts on acid anhydrides (EC 3.6.*.*).
imported from: chebi.owl
has_alternative_id: CHEBI:76765
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.6 inhibitor
has_related_synonym: EC 3.6 inhibitors
has_related_synonym: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors
has_related_synonym: EC 3.6.* inhibitor
has_related_synonym: EC 3.6.* inhibitors
has_related_synonym: EC 3.6.*.* inhibitor
has_related_synonym: EC 3.6.*.* inhibitors
has_related_synonym: acid anhydride hydrolase inhibitor
has_related_synonym: acid anhydride hydrolase inhibitors
has_related_synonym: inhibitor of hydrolase acting on acid anhydride (EC 3.6.*)
has_related_synonym: inhibitors of hydrolase acting on acid anhydride (EC 3.6.*)
id: CHEBI:73216
in subset: 3 STAR

NF-kappaB inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.
imported from: chebi.owl
has cross-reference: Wikipedia:NF-%CE%BAB
alternative_term: NF-kappaB inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: NF-kB inhibitor
has_related_synonym: NF-kB inhibitors
has_related_synonym: NF-kappaB inhibitors
has_related_synonym: Nuclear factor kappa B inhibitor
has_related_synonym: Nuclear factor kappa B inhibitors
has_related_synonym: nuclear factor kappa-light-chain-enhancer of activated B cells inhibitor
has_related_synonym: nuclear factor kappa-light-chain-enhancer of activated B cells inhibitors
id: CHEBI:73240
in subset: 3 STAR

cyclooxygenase 3 inhibitor
type: Class
subclass of: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
textual definition: A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 3.
imported from: chebi.owl
has cross-reference: PMID:12242329
has cross-reference: PMID:12374850
has cross-reference: PMID:14592546
has cross-reference: Wikipedia:COX-3
has_obo_namespace: chebi_ontology
has_related_synonym: COX-3 inhibitor
has_related_synonym: COX-3 inhibitors
has_related_synonym: cyclo-oxygenase 3 inhibitor
has_related_synonym: cyclo-oxygenase 3 inhibitors
has_related_synonym: cyclooxygenase 3 inhibitors
has_related_synonym: cyclooxygenase-3 inhibitor
has_related_synonym: cyclooxygenase-3 inhibitors
id: CHEBI:73263
in subset: 3 STAR

oxidative phosphorylation inhibitor
type: Class
subclass of: inhibitor
textual definition: Any compound that inhibits oxidative phosphorylation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: oxidative phosphorylation inhibitors
id: CHEBI:73267
in subset: 3 STAR

sodium-glucose transport protein subtype 2 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor that interferes with the action of sodium-glucose transport protein subtype 2.
imported from: chebi.owl
has cross-reference: Wikipedia:Sodium/glucose_cotransporter_2
has_obo_namespace: chebi_ontology
has_related_synonym: SGLT2 inhibitor
has_related_synonym: SGLT2 inhibitors
has_related_synonym: sodium glucose co-transporter 2 inhibitor
has_related_synonym: sodium glucose co-transporter 2 inhibitors
has_related_synonym: sodium-glucose transport protein subtype 2 inhibitors
has_related_synonym: sodium/glucose cotransporter 2 inhibitor
has_related_synonym: sodium/glucose cotransporter 2 inhibitors
id: CHEBI:73273
in subset: 3 STAR

cholecystokinin antagonist
type: Class
subclass of: hormone antagonist
textual definition: A hormone antagonist that inhibits the action of the peptide hormone cholecystokinin.
imported from: chebi.owl
has cross-reference: Wikipedia:Cholecystokinin_antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: CCK antagonist
has_related_synonym: CCK antagonists
has_related_synonym: cholecystokinin antagonists
id: CHEBI:73296
in subset: 3 STAR

adenosine A2A receptor agonist
type: Class
subclass of: adenosine receptor agonist
textual definition: An agonist at the A2A receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_A2A_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: A2A agonist
has_related_synonym: A2A agonists
has_related_synonym: A2A receptor agonist
has_related_synonym: A2A receptor agonists
has_related_synonym: adenosine A2A receptor agonists
id: CHEBI:73310
in subset: 3 STAR

adenosine receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist at any adenosine receptor.
imported from: chebi.owl
alternative_term: adenosine receptor agonist
has_obo_namespace: chebi_ontology
id: CHEBI:73311
in subset: 3 STAR

adenosine A3 receptor agonist
type: Class
subclass of: adenosine receptor agonist
textual definition: An agonist at the adenosine A3 receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosine_A3_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: A3 agonist
has_related_synonym: A3 agonists
has_related_synonym: A3 receptor agonist
has_related_synonym: A3 receptor agonists
has_related_synonym: adenosine A3 receptor agonists
id: CHEBI:73319
in subset: 3 STAR

scabicide
type: Class
subclass of: acaricide
textual definition: An acaricide that kills mites of the genus Sarcoptes.
imported from: chebi.owl
has cross-reference: Wikipedia:Scabicide
has_obo_namespace: chebi_ontology
has_related_synonym: scabicides
id: CHEBI:73333
in subset: 3 STAR

thyroid hormone agonist
type: Class
subclass of: hormone agonist
textual definition: A hormone agonist that binds to and activates a thyroid hormone receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Thyroid_hormone_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: thyroid hormone agonists
has_related_synonym: thyromimetic
has_related_synonym: thyromimetics
id: CHEBI:73334
in subset: 3 STAR

ultraviolet filter
type: Class
subclass of: photochemical role
textual definition: A photochemical role realized in the absorption of ultraviolet light, for example to protect skin cells from damage.
imported from: chebi.owl
has cross-reference: Wikipedia:UV_filter
has_obo_namespace: chebi_ontology
has_related_synonym: UV filter
has_related_synonym: UV filters
has_related_synonym: ultraviolet filters
id: CHEBI:73335
in subset: 3 STAR

vulnerary
type: Class
subclass of: drug
textual definition: A drug used in treating and healing of wounds.
imported from: chebi.owl
has cross-reference: Wikipedia:Wound_healing
has_obo_namespace: chebi_ontology
has_related_synonym: vulneraries
has_related_synonym: wound-healing agent
has_related_synonym: wound-healing agents
has_related_synonym: wound-healing drug
has_related_synonym: wound-healing drugs
id: CHEBI:73336
in subset: 3 STAR

protein-sequencing agent
type: Class
subclass of: application
textual definition: Any agent used to determine the amino-acid sequence in a polypeptide.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: protein-sequencing agents
has_related_synonym: sequencing agent
has_related_synonym: sequencing agents
id: CHEBI:73352
in subset: 3 STAR

EC 2.7.3.2 (creatine kinase) inhibitor
type: Class
subclass of: EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor
textual definition: An EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor that interferes with the action of creatine kinase, EC 2.7.3.2.
imported from: chebi.owl
has cross-reference: Wikipedia:Creatine_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: CK inhibitor
has_related_synonym: CK inhibitors
has_related_synonym: CPK inhibitor
has_related_synonym: CPK inhibitors
has_related_synonym: EC 2.7.3.2 (creatine kinase) inhibitors
has_related_synonym: creatine kinase (EC 2.7.3.2) inhibitor
has_related_synonym: creatine kinase (EC 2.7.3.2) inhibitors
has_related_synonym: creatine kinase inhibitor
has_related_synonym: creatine kinase inhibitors
has_related_synonym: creatine phosphokinase inhibitor
has_related_synonym: creatine phosphokinase inhibitors
id: CHEBI:73354
in subset: 3 STAR

EC 3.4.11.18 (methionyl aminopeptidase) inhibitor
type: Class
subclass of: EC 3.4.11.* (aminopeptidase) inhibitor
textual definition: Any EC 3.4.11.* (aminopeptidase) inhibitor that interferes with the action of methionyl aminopeptidase (EC 3.4.11.18).
imported from: chebi.owl
has cross-reference: Wikipedia:Methionyl_aminopeptidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.11.18 (methionyl aminopeptidase) inhibitors
has_related_synonym: EC 3.4.11.18 inhibitor
has_related_synonym: EC 3.4.11.18 inhibitors
has_related_synonym: L-methionine aminopeptidase inhibitor
has_related_synonym: L-methionine aminopeptidase inhibitors
has_related_synonym: MAP inhibitor
has_related_synonym: MAP inhibitors
has_related_synonym: methionine aminopeptidase inhibitor
has_related_synonym: methionine aminopeptidase inhibitors
has_related_synonym: methionyl aminopeptidase (EC 3.4.11.18) inhibitor
has_related_synonym: methionyl aminopeptidase (EC 3.4.11.18) inhibitors
has_related_synonym: methionyl aminopeptidase inhibitor
has_related_synonym: methionyl aminopeptidase inhibitors
has_related_synonym: peptidase M inhibitor
has_related_synonym: peptidase M inhibitors
id: CHEBI:73360
in subset: 3 STAR

methionine aminopeptidase 2 inhibitor
type: Class
subclass of: EC 3.4.11.18 (methionyl aminopeptidase) inhibitor
textual definition: Any methionyl aminopeptidase inhibitor that inhibits the action of methionyl aminopeptidase 2.
imported from: chebi.owl
has cross-reference: Wikipedia:METAP2
has_obo_namespace: chebi_ontology
has_related_synonym: MAP2 inhibitor
has_related_synonym: MAP2 inhibitors
has_related_synonym: METAP2 inhibitor
has_related_synonym: METAP2 inhibitors
has_related_synonym: MetAP2 inhibitor
has_related_synonym: MetAP2 inhibitors
has_related_synonym: methionine aminopeptidase 2 inhibitors
has_related_synonym: methionine aminopeptidase-2 inhibitor
has_related_synonym: methionine aminopeptidase-2 inhibitors
id: CHEBI:73361
in subset: 3 STAR

cannabinoid receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates cannabinoid receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Cannabinoid_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: cannabinoid receptor antagonists
id: CHEBI:73413
in subset: 3 STAR

CB1 receptor antagonist
type: Class
subclass of: cannabinoid receptor antagonist
textual definition: An antagonist that binds to and deactivates type 1 cannabinoid receptors.
imported from: chebi.owl
has cross-reference: PMID:22463610
has cross-reference: Wikipedia:Cannabinoid_receptor_type_1
alternative_term: CB1 receptor antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: CB1 receptor antagonists
has_related_synonym: CB1R antagonist
has_related_synonym: CB1R antagonists
has_related_synonym: cannabinoid receptor 1 antagonist
has_related_synonym: cannabinoid receptor 1 antagonists
has_related_synonym: cannabinoid receptor type 1 antagonist
has_related_synonym: cannabinoid receptor type 1 antagonists
has_related_synonym: type 1 cannabinoid receptor antagonist
has_related_synonym: type 1 cannabinoid receptor antagonists
id: CHEBI:73416
in subset: 3 STAR

CB2 receptor antagonist
type: Class
subclass of: cannabinoid receptor antagonist
textual definition: An antagonist that binds to and deactivates type 2 cannabinoid receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Cannabinoid_receptor_type_2
alternative_term: CB2 receptor antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: CB2 receptor antagonists
has_related_synonym: CB2R antagonist
has_related_synonym: CB2R antagonists
has_related_synonym: cannabinoid receptor 2 antagonist
has_related_synonym: cannabinoid receptor 2 antagonists
has_related_synonym: cannabinoid receptor type 2 antagonist
has_related_synonym: cannabinoid receptor type 2 antagonists
has_related_synonym: type 2 cannabinoid receptor antagonist
has_related_synonym: type 2 cannabinoid receptor antagonists
id: CHEBI:73417
in subset: 3 STAR

kynuramine
type: Class
subclass of: molecular entity
textual definition: A member of the class of kynurenamines that is aniline substituted at position 2 by a 3-aminopropanoyl group.
imported from: chebi.owl
charge: 0
formula: C9H12N2O
inchi: InChI=1S/C9H12N2O/c10-6-5-9(12)7-3-1-2-4-8(7)11/h1-4H,5-6,10-11H2
inchikey: QLPVTIQQFGWSQQ-UHFFFAOYSA-N
mass: 164.20440
monoisotopicmass: 164.09496
smiles: NCCC(=O)c1ccccc1N
has_alternative_id: CHEBI:24989
has cross-reference: CAS:363-36-0
has cross-reference: Chemspider:9311
has cross-reference: FooDB:FDB028888
has cross-reference: HMDB:HMDB0012246
has cross-reference: PMID:13843767
has cross-reference: PMID:14332461
has cross-reference: PMID:22547660
has cross-reference: PMID:3428356
has cross-reference: PMID:34648288
has cross-reference: PMID:3572806
has cross-reference: PMID:4017223
has cross-reference: PMID:4384132
has cross-reference: PMID:497017
has cross-reference: PMID:510362
has cross-reference: PMID:5472592
has cross-reference: PMID:562342
has cross-reference: PMID:6115758
has cross-reference: PMID:6132830
has cross-reference: PMID:6140297
has cross-reference: PMID:6503615
has cross-reference: PMID:6519183
has cross-reference: PMID:6877035
has cross-reference: Patent:WO2006061140
has cross-reference: Reaxys:2802772
alternative_term: 3-amino-1-(2-aminophenyl)propan-1-one
has_obo_namespace: chebi_ontology
has_related_synonym: 2',3-diaminopropiophenone
has_related_synonym: 3-amino-1-(2-aminophenyl)-1-propanone
has_related_synonym: kynurenamine
id: CHEBI:73472
in subset: 3 STAR

spectrophotometric reagent
type: Class
subclass of: reagent
textual definition: A reagent used in the determination by spectrophotometry of the concentration of a chemical element or chemical compound in solution.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: spectrophotometric reagents
id: CHEBI:73618
in subset: 3 STAR

tolerogen
type: Class
subclass of: biological role
textual definition: A substance that invokes a specific immune non-responsiveness due to its molecular form. If its molecular form is changed, a tolerogen can become an immunogen.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: tolerogens
id: CHEBI:73623
in subset: 3 STAR

peptide coupling reagent
type: Class
subclass of: reagent
textual definition: A reagent used to couple amino acids during artificial peptide synthesis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: peptide coupling reagents
id: CHEBI:73668
in subset: 3 STAR

PPARbeta/delta agonist
type: Class
subclass of: agonist
subclass of: PPAR modulator
textual definition: A PPAR modulator which activates the peroxisome proliferator-activated receptor-beta/delta.
imported from: chebi.owl
has_alternative_id: CHEBI:73729
has cross-reference: Wikipedia:Peroxisome_proliferator-activated_receptor_delta
alternative_term: PPARbeta/delta agonist
has_obo_namespace: chebi_ontology
has_related_synonym: NR1C2 agonist
has_related_synonym: NR1C2 agonists
has_related_synonym: PPAR(beta/delta) agonist
has_related_synonym: PPAR(beta/delta) agonists
has_related_synonym: PPAR-beta agonist
has_related_synonym: PPAR-beta agonists
has_related_synonym: PPAR-beta/delta agonist
has_related_synonym: PPAR-beta/delta agonists
has_related_synonym: PPAR-delta agonist
has_related_synonym: PPAR-delta agonists
has_related_synonym: PPARD agonist
has_related_synonym: PPARD agonists
has_related_synonym: PPARD receptor agonist
has_related_synonym: PPARD receptor agonists
has_related_synonym: PPARbeta agonist
has_related_synonym: PPARbeta agonists
has_related_synonym: PPARbeta/delta agonists
has_related_synonym: PPARdelta agonist
has_related_synonym: PPARdelta agonists
has_related_synonym: nuclear receptor subfamily 1, group C, member 2 agonist
has_related_synonym: nuclear receptor subfamily 1, group C, member 2 agonists
has_related_synonym: peroxisome proliferator-activated receptor-beta agonist
has_related_synonym: peroxisome proliferator-activated receptor-beta agonists
has_related_synonym: peroxisome proliferator-activated receptor-delta agonist
has_related_synonym: peroxisome proliferator-activated receptor-delta agonists
id: CHEBI:73730
in subset: 3 STAR

vibriostatic agent
type: Class
subclass of: antibacterial agent
textual definition: Any compound that inhibits the growth of bacteria of the genus Vibrio.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: vibriostatic
has_related_synonym: vibriostatics
id: CHEBI:73911
in subset: 3 STAR

antifolate
type: Class
subclass of: antimetabolite
textual definition: An antimetabolite that impairs the action of folic acids
imported from: chebi.owl
has cross-reference: Wikipedia:Antifolate
has_obo_namespace: chebi_ontology
has_related_synonym: antifolates
has_related_synonym: folic acid antagonist
has_related_synonym: folic acid antagonists
id: CHEBI:73913
in subset: 3 STAR

nitric oxide synthase activator
type: Class
subclass of: enzyme activator
textual definition: Any compound that binds to and activates the enzyme nitric oxide synthase (EC 1.14.13.39).
imported from: chebi.owl
has cross-reference: Wikipedia:Nitric_oxide_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: NOS activator
has_related_synonym: NOS activators
has_related_synonym: nitric oxide synthase activators
id: CHEBI:73966
in subset: 3 STAR

lachrymator
type: Class
subclass of: biophysical role
textual definition: Any substance that stimulates the corneal nerves in the eves to cause tears.
imported from: chebi.owl
has cross-reference: PMID:4919431
has_obo_namespace: chebi_ontology
has_related_synonym: lachrymators
id: CHEBI:74136
in subset: 3 STAR

mordant
type: Class
subclass of: application
textual definition: Substance used to set dyes on fabrics or tissue sections by forming a coordination complex with the dye which then attaches to the fabric or tissue.
imported from: chebi.owl
has cross-reference: Wikipedia:Mordant
has_obo_namespace: chebi_ontology
id: CHEBI:74152
in subset: 3 STAR

EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor
type: Class
subclass of: EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor
textual definition: An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Ribonucleoside-diphosphate_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitor
has_related_synonym: 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitors
has_related_synonym: ADP reductase inhibitor
has_related_synonym: ADP reductase inhibitors
has_related_synonym: CDP reductase inhibitor
has_related_synonym: CDP reductase inhibitors
has_related_synonym: EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitors
has_related_synonym: EC 1.17.4.1 inhibitor
has_related_synonym: EC 1.17.4.1 inhibitors
has_related_synonym: RR inhibitor
has_related_synonym: RR inhibitors
has_related_synonym: UDP reductase inhibitor
has_related_synonym: UDP reductase inhibitors
has_related_synonym: nucleoside diphosphate reductase inhibitor
has_related_synonym: nucleoside diphosphate reductase inhibitors
has_related_synonym: ribonucleoside diphosphate reductase inhibitor
has_related_synonym: ribonucleoside diphosphate reductase inhibitors
has_related_synonym: ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitor
has_related_synonym: ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitors
has_related_synonym: ribonucleoside-diphosphate reductase inhibitor
has_related_synonym: ribonucleoside-diphosphate reductase inhibitors
has_related_synonym: ribonucleotide diphosphate reductase inhibitor
has_related_synonym: ribonucleotide diphosphate reductase inhibitors
has_related_synonym: ribonucleotide reductase inhibitor
has_related_synonym: ribonucleotide reductase inhibitors
id: CHEBI:74213
in subset: 3 STAR

EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the activity of sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), EC 1.1.1.153, which plays an important part in the biosynthesis of tetrahydrobiopterin.
imported from: chebi.owl
has cross-reference: Wikipedia:Sepiapterin_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: 7,8-dihydrobiopterin:NADP(+) oxidoreductase
has_related_synonym: 7,8-dihydrobiopterin:NADP(+) oxidoreductases
has_related_synonym: EC 1.1.1.153 (sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)) inhibitor
has_related_synonym: EC 1.1.1.153 (sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)) inhibitors
has_related_synonym: EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitors
has_related_synonym: L-erythro-7,8-dihydrobiopterin:NADP(+) oxidoreductase inhibitor
has_related_synonym: L-erythro-7,8-dihydrobiopterin:NADP(+) oxidoreductase inhibitors
has_related_synonym: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) (EC 1.1.1.153) inhibitor
has_related_synonym: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) (EC 1.1.1.153) inhibitors
has_related_synonym: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) inhibitor
has_related_synonym: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) inhibitors
has_related_synonym: sepiapterin reductase inhibitor
has_related_synonym: sepiapterin reductase inhibitors
id: CHEBI:74234
in subset: 3 STAR

polymerisation monomer
type: Class
subclass of: chemical role
textual definition: Any compound used as a monomer for a polymerisation process. The term is generally used in relation to industrial polymerisation processes.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: polymerization monomer
id: CHEBI:74236
in subset: 3 STAR

quinol oxidation site inhibitor
type: Class
subclass of: inhibitor
textual definition: An compound that inhibits quinol oxidation sites.
imported from: chebi.owl
has cross-reference: PMID:15312779
has cross-reference: PMID:7961852
has_obo_namespace: chebi_ontology
has_related_synonym: QP site inhibitor
has_related_synonym: QP site inhibitors
has_related_synonym: quinol oxidation site inhibitors
id: CHEBI:74352
in subset: 3 STAR

epidermal growth factor receptor antagonist
type: Class
subclass of: protein kinase inhibitor
subclass of: antagonist
textual definition: An antagonist at the epidermal growth factor receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Epidermal_growth_factor_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: EGFR antagonoist
has_related_synonym: EGFR antagonoists
has_related_synonym: EGFR inhibitor
has_related_synonym: EGFR inhibitors
has_related_synonym: epidermal growth factor receptor antagonists
has_related_synonym: epidermal growth factor receptor inhibitor
has_related_synonym: epidermal growth factor receptor inhibitors
id: CHEBI:74440
in subset: 3 STAR

anti-obesity agent
type: Class
subclass of: pharmacological role
textual definition: Any substance which is used to reduce or control weight.
imported from: chebi.owl
has cross-reference: Wikipedia:Anti-obesity
has_obo_namespace: chebi_ontology
has_related_synonym: anti-obesity agents
has_related_synonym: anti-obestic agent
has_related_synonym: anti-obestic agents
id: CHEBI:74518
in subset: 3 STAR

EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase (EC 1.1.1.44).
imported from: chebi.owl
has cross-reference: Wikipedia:Phosphogluconate_dehydrogenase_(decarboxylating)
has_obo_namespace: chebi_ontology
has_related_synonym: 6-phospho-D-gluconate dehydrogenase inhibitor
has_related_synonym: 6-phospho-D-gluconate dehydrogenase inhibitors
has_related_synonym: 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) inhibitor
has_related_synonym: 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) inhibitors
has_related_synonym: 6-phosphogluconate dehydrogenase (decarboxylating) inhibitor
has_related_synonym: 6-phosphogluconate dehydrogenase (decarboxylating) inhibitors
has_related_synonym: 6-phosphogluconic carboxylase inhibitor
has_related_synonym: 6-phosphogluconic carboxylase inhibitors
has_related_synonym: 6-phosphogluconic dehydrogenase inhibitor
has_related_synonym: 6-phosphogluconic dehydrogenase inhibitors
has_related_synonym: EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.44 inhibitor
has_related_synonym: EC 1.1.1.44 inhibitors
has_related_synonym: NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase (EC 1.1.1.44) inhibitor
has_related_synonym: NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase (EC 1.1.1.44) inhibitors
has_related_synonym: NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase inhibitor
has_related_synonym: NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase inhibitors
has_related_synonym: phosphogluconate dehydrogenase (NADP+ -dependent, decarboxylating) inhibitor
has_related_synonym: phosphogluconate dehydrogenase (NADP+ -dependent, decarboxylating) inhibitors
has_related_synonym: phosphogluconic acid dehydrogenase inhibitor
has_related_synonym: phosphogluconic acid dehydrogenase inhibitors
id: CHEBI:74520
in subset: 3 STAR

antidote to paracetamol poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralize the deleterious effects of paracetamol (acetaminophen).
imported from: chebi.owl
has cross-reference: PMID:16354242
has cross-reference: PMID:16573399
has cross-reference: PMID:16575097
has cross-reference: PMID:22348679
has cross-reference: PMID:22352734
has cross-reference: PMID:22353666
has cross-reference: PMID:22835053
has cross-reference: PMID:22998987
has cross-reference: PMID:7112203
has_obo_namespace: chebi_ontology
has_related_synonym: Tylenol poisoning antidote
has_related_synonym: Tylenol poisoning antidotes
has_related_synonym: acetaminophen poisoning antidote
has_related_synonym: acetaminophen poisoning antidotes
has_related_synonym: antidote to Tylenol poisoning
has_related_synonym: antidote to acetaminophen poisoning
has_related_synonym: antidotes to Tylenol poisoning
has_related_synonym: antidotes to acetaminophen poisoning
has_related_synonym: antidotes to paracetamol poisoning
has_related_synonym: paracetamol poisoning antidote
has_related_synonym: paracetamol poisoning antidotes
id: CHEBI:74529
in subset: 3 STAR

antidote to curare poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralize the deleterious effects of curare.
imported from: chebi.owl
has cross-reference: PMID:13358565
has cross-reference: PMID:13386996
has cross-reference: PMID:14128111
has cross-reference: PMID:1579914
has cross-reference: PMID:3896015
has cross-reference: PMID:5333582
has cross-reference: PMID:5352084
has cross-reference: PMID:7720787
has_obo_namespace: chebi_ontology
has_related_synonym: antidote to curare
has_related_synonym: antidote to tubocurarine
has_related_synonym: antidote to tubocurarine poisoning
has_related_synonym: antidotes to curare
has_related_synonym: antidotes to curare poisoning
has_related_synonym: antidotes to tubocurarine
has_related_synonym: antidotes to tubocurarine poisoning
has_related_synonym: curare antidote
has_related_synonym: curare antidotes
has_related_synonym: curare poisoning antidote
has_related_synonym: curare poisoning antidotes
has_related_synonym: tubocurarine antidote
has_related_synonym: tubocurarine antidotes
id: CHEBI:74530
in subset: 3 STAR

EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor
type: Class
subclass of: EC 2.3.2.* (aminoacyltransferase) inhibitor
textual definition: An EC 2.3.2.* (aminoacyltransferase) inhibitor that interferes with the action of gamma-glutamyltransferase (EC 2.3.2.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Gamma-glutamyl_transpeptidase
has_obo_namespace: chebi_ontology
has_related_synonym: (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase inhibitor
has_related_synonym: (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase inhibitors
has_related_synonym: EC 2.3.2.2 (gamma-glutamyltransferase) inhibitors
has_related_synonym: EC 2.3.2.2 inhibitor
has_related_synonym: EC 2.3.2.2 inhibitors
has_related_synonym: GGT inhibitor
has_related_synonym: GGT inhibitors
has_related_synonym: L-gamma-glutamyl transpeptidase inhibitor
has_related_synonym: L-gamma-glutamyl transpeptidase inhibitors
has_related_synonym: L-gamma-glutamyltransferase inhibitor
has_related_synonym: L-gamma-glutamyltransferase inhibitors
has_related_synonym: L-glutamyltransferase inhibitor
has_related_synonym: L-glutamyltransferase inhibitors
has_related_synonym: alpha-glutamyl transpeptidase inhibitor
has_related_synonym: alpha-glutamyl transpeptidase inhibitors
has_related_synonym: gamma-GPT inhibitor
has_related_synonym: gamma-GPT inhibitors
has_related_synonym: gamma-GT inhibitor
has_related_synonym: gamma-GT inhibitors
has_related_synonym: gamma-GTP inhibitor
has_related_synonym: gamma-GTP inhibitors
has_related_synonym: gamma-glutamyl peptidyltransferase inhibitor
has_related_synonym: gamma-glutamyl peptidyltransferase inhibitors
has_related_synonym: gamma-glutamyl transpeptidase inhibitor
has_related_synonym: gamma-glutamyl transpeptidase inhibitors
has_related_synonym: gamma-glutamyltransferase (EC 2.3.2.2) inhibitor
has_related_synonym: gamma-glutamyltransferase (EC 2.3.2.2) inhibitors
has_related_synonym: gamma-glutamyltransferase inhibitor
has_related_synonym: gamma-glutamyltransferase inhibitors
has_related_synonym: gamma-glutamyltranspeptidase inhibitor
has_related_synonym: gamma-glutamyltranspeptidase inhibitors
has_related_synonym: glutamyl transpeptidase inhibitor
has_related_synonym: glutamyl transpeptidase inhibitors
id: CHEBI:74570
in subset: 3 STAR

astringent
type: Class
subclass of: drug
textual definition: A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.
imported from: chebi.owl
has cross-reference: Wikipedia:Astringent
has_obo_namespace: chebi_ontology
has_related_synonym: adstringent
has_related_synonym: adstringents
has_related_synonym: astringents
id: CHEBI:74783
in subset: 3 STAR

neoglycolipid probe
type: Class
subclass of: application
textual definition: A compound used as a probe during microarray analysis of oligosaccharide-protein interactions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:74886
in subset: 3 STAR

microarray analysis reagent
type: Class
subclass of: reagent
textual definition: A reagent used in the immobilization of compounds prior to their use in microarray analysis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: microarray analysis reagents
id: CHEBI:74914
in subset: 3 STAR

EC 3.4.23.46 (memapsin 2) inhibitor
type: Class
subclass of: EC 3.4.23.* (aspartic endopeptidase) inhibitor
textual definition: An EC 3.4.23.* (aspartic endopeptidase) inhibitor that interferes with the activity of memapsin 2 (EC 3.4.23.46).
imported from: chebi.owl
has cross-reference: Wikipedia:Gamma_secretase
has_obo_namespace: chebi_ontology
has_related_synonym: BACE1 inhibitor
has_related_synonym: BACE1 inhibitors
has_related_synonym: EC 3.4.23.46 (memapsin 2) inhibitors
has_related_synonym: EC 3.4.23.46 inhibitor
has_related_synonym: EC 3.4.23.46 inhibitors
has_related_synonym: Gamma-secretase inhibitor
has_related_synonym: Gamma-secretase inhibitors
has_related_synonym: beta-secretase inhibitor
has_related_synonym: beta-secretase inhibitors
has_related_synonym: beta-site APP-cleaving enzyme 1 inhibitor
has_related_synonym: beta-site APP-cleaving enzyme 1 inhibitors
has_related_synonym: beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor
has_related_synonym: beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors
has_related_synonym: beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 inhibitor
has_related_synonym: beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 inhibitors
has_related_synonym: gamma-secretase inhibitor
has_related_synonym: gamma-secretase inhibitors
has_related_synonym: memapsin 2 (EC 3.4.23.46) inhibitor
has_related_synonym: memapsin 2 (EC 3.4.23.46) inhibitors
has_related_synonym: memapsin 2 inhibitor
has_related_synonym: memapsin 2 inhibitors
has_related_synonym: membrane-associated aspartic protease 2 inhibitor
has_related_synonym: membrane-associated aspartic protease 2 inhibitors
id: CHEBI:74925
in subset: 3 STAR

EC 3.1.27.3 (ribonuclease T1) inhibitor
type: Class
subclass of: EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitor
textual definition: An EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitor that interferes with the action of ribonuclease T1 (EC 3.1.27.3).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Aspergillus oryzae ribonuclease inhibitor
has_related_synonym: Aspergillus oryzae ribonuclease inhibitors
has_related_synonym: EC 3.1.27.3 (ribonuclease T1) inhibitors
has_related_synonym: EC 3.1.27.3 inhibitor
has_related_synonym: EC 3.1.27.3 inhibitors
has_related_synonym: RNase F1 inhibitor
has_related_synonym: RNase F1 inhibitors
has_related_synonym: RNase G inhibitor
has_related_synonym: RNase G inhibitors
has_related_synonym: RNase N1 inhibitor
has_related_synonym: RNase N1 inhibitors
has_related_synonym: RNase N2 inhibitor
has_related_synonym: RNase N2 inhibitors
has_related_synonym: RNase Sa inhibitor
has_related_synonym: RNase Sa inhibitors
has_related_synonym: RNase T1 inhibitor
has_related_synonym: RNase T1 inhibitors
has_related_synonym: T1 inhibitor
has_related_synonym: T1 inhibitors
has_related_synonym: binase inhibitor
has_related_synonym: binase inhibitors
has_related_synonym: guanyl-specific RNase inhibitor
has_related_synonym: guanyl-specific RNase inhibitors
has_related_synonym: guanyloribonuclease inhibitor
has_related_synonym: guanyloribonuclease inhibitors
has_related_synonym: ribonuclease C2 inhibitor
has_related_synonym: ribonuclease C2 inhibitors
has_related_synonym: ribonuclease Ch inhibitor
has_related_synonym: ribonuclease Ch inhibitors
has_related_synonym: ribonuclease F1 inhibitor
has_related_synonym: ribonuclease F1 inhibitors
has_related_synonym: ribonuclease N1 inhibitor
has_related_synonym: ribonuclease N1 inhibitors
has_related_synonym: ribonuclease N3 inhibitor
has_related_synonym: ribonuclease N3 inhibitors
has_related_synonym: ribonuclease PP1 inhibitor
has_related_synonym: ribonuclease PP1 inhibitors
has_related_synonym: ribonuclease SA inhibitor
has_related_synonym: ribonuclease SA inhibitors
has_related_synonym: ribonuclease T1 (EC 3.1.27.3) inhibitor
has_related_synonym: ribonuclease T1 (EC 3.1.27.3) inhibitors
has_related_synonym: ribonuclease T1 inhibitor
has_related_synonym: ribonuclease T1 inhibitors
has_related_synonym: ribonuclease U1 inhibitor
has_related_synonym: ribonuclease U1 inhibitors
has_related_synonym: ribonuclease guaninenucleotido-2'-transferase (cyclising) inhibitor
has_related_synonym: ribonuclease guaninenucleotido-2'-transferase (cyclising) inhibitors
has_related_synonym: ribonuclease guaninenucleotido-2'-transferase (cyclizing) inhibitor
has_related_synonym: ribonuclease guaninenucleotido-2'-transferase (cyclizing) inhibitors
id: CHEBI:74949
in subset: 3 STAR

B-Raf inhibitor
type: Class
subclass of: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
textual definition: A serine/threonine kinase inhibitor that specifically inhibits human mutant serine/threonine kinase (B-Raf)
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: B-Raf inhibitors
has_related_synonym: BRAF inhibitor
has_related_synonym: BRAF inhibitors
has_related_synonym: human mutant serine/threonine kinase inhibitor
has_related_synonym: human mutant serine/threonine kinase inhibitors
id: CHEBI:75047
in subset: 3 STAR

chromogenic compound
type: Class
subclass of: one-colour indicator
textual definition: Colourless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into coloured compounds. They are used in biochemical assays and in diagnosis as indicators, particularly in the form of enzyme substrates.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: chromogen
has_related_synonym: chromogenic compounds
has_related_synonym: chromogens
id: CHEBI:75050
in subset: 3 STAR

EC 2.5.1.21 (squalene synthase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of squalene synthase (EC 2.5.1.21).
imported from: chebi.owl
has cross-reference: Wikipedia:Squalene_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.1.21 (squalene synthase) inhibitors
has_related_synonym: EC 2.5.1.21 inhibitor
has_related_synonym: EC 2.5.1.21 inhibitors
has_related_synonym: SQS inhibitor
has_related_synonym: SQS inhibitors
has_related_synonym: farnesyl-diphosphate farnesyltransferase inhibitor
has_related_synonym: farnesyl-diphosphate farnesyltransferase inhibitors
has_related_synonym: farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase inhibitor
has_related_synonym: farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase inhibitors
has_related_synonym: farnesyltransferase inhibitor
has_related_synonym: farnesyltransferase inhibitors
has_related_synonym: presqualene synthase inhibitor
has_related_synonym: presqualene synthase inhibitors
has_related_synonym: presqualene-diphosphate synthase inhibitor
has_related_synonym: presqualene-diphosphate synthase inhibitors
has_related_synonym: squalene synthase (EC 2.5.1.21) inhibitor
has_related_synonym: squalene synthase (EC 2.5.1.21) inhibitors
has_related_synonym: squalene synthase inhibitor
has_related_synonym: squalene synthase inhibitors
has_related_synonym: squalene synthetase inhibitor
has_related_synonym: squalene synthetase inhibitors
id: CHEBI:75174
in subset: 3 STAR

EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor
type: Class
subclass of: EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitor
textual definition: An EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitor that interferes with the action of lysine 2,3-aminomutase (EC 5.4.3.2).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitors
has_related_synonym: EC 5.4.3.2 inhibitor
has_related_synonym: EC 5.4.3.2 inhibitors
has_related_synonym: L-lysine 2,3-aminomutase inhibitor
has_related_synonym: L-lysine 2,3-aminomutase inhibitors
has_related_synonym: lysine 2,3-aminomutase (EC 5.4.3.2) inhibitor
has_related_synonym: lysine 2,3-aminomutase (EC 5.4.3.2) inhibitors
has_related_synonym: lysine 2,3-aminomutase inhibitor
has_related_synonym: lysine 2,3-aminomutase inhibitors
id: CHEBI:75190
in subset: 3 STAR

insulin-like growth factor receptor 1 antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the insulin-like growth factor receptor 1.
imported from: chebi.owl
has cross-reference: Wikipedia:Insulin-like_growth_factor_1_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: IGF-1R antagonist
has_related_synonym: IGF-1R antagonists
has_related_synonym: insulin-like growth factor receptor 1 antagonists
id: CHEBI:75252
in subset: 3 STAR

ergosterol biosynthesis inhibitor
type: Class
subclass of: sterol biosynthesis inhibitor
textual definition: Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol.
imported from: chebi.owl
has cross-reference: PMID:12604527
has cross-reference: PMID:19835945
has_obo_namespace: chebi_ontology
has_related_synonym: ergosterol biosynthesis inhibitors
id: CHEBI:75282
in subset: 3 STAR

histamine releasing agent
type: Class
subclass of: biochemical role
textual definition: Any substance that can induce the release of histamine from mast cells.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: histamine releasing agents
has_related_synonym: histamine releasing compound
has_related_synonym: histamine releasing compounds
has_related_synonym: histamine releasing substance
has_related_synonym: histamine releasing substances
id: CHEBI:75298
in subset: 3 STAR

excipient
type: Class
subclass of: application
textual definition: A generally pharmacologically inactive substance that is formulated with the active ingredient of a medication.
imported from: chebi.owl
has cross-reference: PMID:19709488
has cross-reference: PMID:21086329
has cross-reference: PMID:22707004
has cross-reference: PMID:22877709
has cross-reference: PMID:23450581
has cross-reference: PMID:23525964
has cross-reference: PMID:23657359
has cross-reference: Wikipedia:Excipient
alternative_term: excipient
has_obo_namespace: chebi_ontology
has_related_synonym: bulking agent
has_related_synonym: bulking agents
has_related_synonym: filler
has_related_synonym: fillers
id: CHEBI:75324
in subset: 3 STAR

cathartic
type: Class
subclass of: biophysical role
textual definition: Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic.
imported from: chebi.owl
has cross-reference: Wikipedia:Cathartic
has_obo_namespace: chebi_ontology
has_related_synonym: cathartics
id: CHEBI:75325
in subset: 3 STAR

curing agent
type: Class
subclass of: application
textual definition: A chemical additive used to toughen or harden a polymer material by cross-linking of polymer chains.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: curing agents
has_related_synonym: vulcanization agent
has_related_synonym: vulcanization agents
has_related_synonym: vulcanizing agent
has_related_synonym: vulcanizing agents
id: CHEBI:75358
in subset: 3 STAR

EC 1.11.1.6 (catalase) inhibitor
type: Class
subclass of: EC 1.11.1.* (peroxidases) inhibitor
textual definition: An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of catalase (EC 1.11.1.6).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CAT inhibitor
has_related_synonym: CAT inhibitors
has_related_synonym: EC 1.11.1.6 (catalase) inhibitors
has_related_synonym: EC 1.11.1.6 inhibitor
has_related_synonym: EC 1.11.1.6 inhibitors
has_related_synonym: caperase inhibitor
has_related_synonym: caperase inhibitors
has_related_synonym: catalase (EC 1.11.1.6) inhibitor
has_related_synonym: catalase (EC 1.11.1.6) inhibitors
has_related_synonym: catalase inhibitor
has_related_synonym: catalase inhibitors
has_related_synonym: catalase-peroxidase inhibitor
has_related_synonym: catalase-peroxidase inhibitors
has_related_synonym: equilase inhibitor
has_related_synonym: equilase inhibitors
has_related_synonym: hydrogen-peroxide:hydrogen-peroxide oxidoreductase inhibitor
has_related_synonym: hydrogen-peroxide:hydrogen-peroxide oxidoreductase inhibitors
has_related_synonym: optidase inhibitor
has_related_synonym: optidase inhibitors
id: CHEBI:75380
in subset: 3 STAR

EC 1.11.1.* (peroxidases) inhibitor
type: Class
subclass of: EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor
textual definition: An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any of the peroxidases (EC 1.11.1.*).
imported from: chebi.owl
has cross-reference: Wikipedia:Peroxidases
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.11.1 inhibitor
has_related_synonym: EC 1.11.1 inhibitors
has_related_synonym: EC 1.11.1.* (peroxidase) inhibitor
has_related_synonym: EC 1.11.1.* (peroxidase) inhibitors
has_related_synonym: EC 1.11.1.* (peroxidases) inhibitors
has_related_synonym: EC 1.11.1.* inhibitor
has_related_synonym: EC 1.11.1.* inhibitors
has_related_synonym: inhibitor of peroxidases
has_related_synonym: inhibitors of peroxidases
has_related_synonym: peroxidases inhibitors
id: CHEBI:75381
in subset: 3 STAR

platelet-activating factor receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates platelet-activating factor receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Platelet-activating_factor_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: platelet-activating factor receptor agonists
id: CHEBI:75414
in subset: 3 STAR

EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor
type: Class
subclass of: EC 6.1.* (C-O bond-forming ligase) inhibitor
textual definition: An EC 6.1.* (C-O bond-forming ligase) inhibitor that interferes with the action of any ligase forming aminoacyl tRNA and related compounds (EC 6.1.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitors
has_related_synonym: EC 6.1.1.* inhibitor
has_related_synonym: EC 6.1.1.* inhibitors
has_related_synonym: aminoacyl tRNA synthetase inhibitor
has_related_synonym: aminoacyl tRNA synthetase inhibitors
has_related_synonym: ligases forming aminoacyl tRNA and related compounds (EC 6.1.1.*) inhibitor
has_related_synonym: ligases forming aminoacyl tRNA and related compounds (EC 6.1.1.*) inhibitors
has_related_synonym: tRNA synthetase inhibitor
has_related_synonym: tRNA synthetase inhibitors
id: CHEBI:75416
in subset: 3 STAR

EC 1.4.4.2 [glycine dehydrogenase (aminomethyl-transferring)] inhibitor
type: Class
subclass of: EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitor
textual definition: An EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitor that interferes with the action of glycine decarboxylase (EC 1.4.4.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Glycine_cleavage_system
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.4.2 (glycine dehydrogenase (aminomethyl-transferring)) inhibitor
has_related_synonym: EC 1.4.4.2 (glycine dehydrogenase (aminomethyl-transferring)) inhibitors
has_related_synonym: EC 1.4.4.2 [glycine dehydrogenase (aminomethyl-transferring)] inhibitors
has_related_synonym: EC 1.4.4.2 inhibitor
has_related_synonym: EC 1.4.4.2 inhibitors
has_related_synonym: P-protein inhibitor
has_related_synonym: P-protein inhibitors
has_related_synonym: glycine cleavage system P-protein inhibitor
has_related_synonym: glycine cleavage system P-protein inhibitors
has_related_synonym: glycine decarboxylase inhibitor
has_related_synonym: glycine decarboxylase inhibitors
has_related_synonym: glycine dehydrogenase (aminomethyl-transferring) (EC 1.4.4.2) inhibitor
has_related_synonym: glycine dehydrogenase (aminomethyl-transferring) (EC 1.4.4.2) inhibitors
has_related_synonym: glycine dehydrogenase (aminomethyl-transferring) inhibitor
has_related_synonym: glycine dehydrogenase (aminomethyl-transferring) inhibitors
has_related_synonym: glycine dehydrogenase (decarboxylating) inhibitor
has_related_synonym: glycine dehydrogenase (decarboxylating) inhibitors
has_related_synonym: glycine-cleavage complex P-protein inhibitor
has_related_synonym: glycine-cleavage complex P-protein inhibitors
has_related_synonym: glycine-cleavage complex inhibitor
has_related_synonym: glycine-cleavage complex inhibitors
has_related_synonym: glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
has_related_synonym: glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating) inhibitor
has_related_synonym: glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) inhibitor
has_related_synonym: glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) inhibitors
has_related_synonym: protein P1 inhibitor
has_related_synonym: protein P1 inhibitors
id: CHEBI:75429
in subset: 3 STAR

EC 6.1.1.11 (serine--tRNA ligase) inhibitor
type: Class
subclass of: EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor
textual definition: An EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor that specifically inhibits the action of seryl-tRNA synthetase (EC 6.1.1.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Serine-tRNA_ligase
alternative_term: EC 6.1.1.11 (serine--tRNA ligase) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.1.1.11 (serine--tRNA ligase) inhibitors
has_related_synonym: EC 6.1.1.11 inhibitor
has_related_synonym: EC 6.1.1.11 inhibitors
has_related_synonym: L-serine:tRNA(Ser) ligase (AMP-forming) inhibitor
has_related_synonym: L-serine:tRNA(Ser) ligase (AMP-forming) inhibitors
has_related_synonym: SerRS inhibitor
has_related_synonym: SerRS inhibitors
has_related_synonym: serine translase inhibitor
has_related_synonym: serine translase inhibitors
has_related_synonym: serine--tRNA ligase (EC 6.1.1.11) inhibitor
has_related_synonym: serine--tRNA ligase (EC 6.1.1.11) inhibitors
has_related_synonym: serine--tRNA ligase inhibitor
has_related_synonym: serine--tRNA ligase inhibitors
has_related_synonym: seryl-tRNA synthetase inhibitor
has_related_synonym: seryl-tRNA synthetase inhibitors
has_related_synonym: seryl-transfer RNA synthetase inhibitor
has_related_synonym: seryl-transfer RNA synthetase inhibitors
has_related_synonym: seryl-transfer ribonucleate synthetase inhibitor
has_related_synonym: seryl-transfer ribonucleate synthetase inhibitors
has_related_synonym: seryl-transfer ribonucleic acid synthetase inhibitor
has_related_synonym: seryl-transfer ribonucleic acid synthetase inhibitors
id: CHEBI:75495
in subset: 3 STAR

EC 5.1.1.1 (alanine racemase) inhibitor
type: Class
subclass of: EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitor
textual definition: An EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitor that interferes with the action of alanine racemase (EC 5.1.1.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Alanine_racemase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.1.1.1 (alanine racemase) inhibitors
has_related_synonym: EC 5.1.1.1 inhibitor
has_related_synonym: EC 5.1.1.1 inhibitors
has_related_synonym: L-alanine racemase inhibitor
has_related_synonym: L-alanine racemase inhibitors
has_related_synonym: alanine racemase (EC 5.1.1.1) inhibitor
has_related_synonym: alanine racemase (EC 5.1.1.1) inhibitors
has_related_synonym: alanine racemase inhibitor
has_related_synonym: alanine racemase inhibitors
id: CHEBI:75595
in subset: 3 STAR

EC 5.* (isomerase) inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.* (isomerase) inhibitors
has_related_synonym: EC 5.* inhibitor
has_related_synonym: EC 5.* inhibitors
has_related_synonym: EC 5.*.*.* inhibitor
has_related_synonym: EC 5.*.*.* inhibitors
has_related_synonym: isomerase (EC 5.*) inhibitor
has_related_synonym: isomerase (EC 5.*) inhibitors
has_related_synonym: isomerase inhibitor
has_related_synonym: isomerase inhibitors
id: CHEBI:75596
in subset: 3 STAR

EC 6.3.2.4 (D-alanine--D-alanine ligase) inhibitor
type: Class
subclass of: EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor
textual definition: An acid--amino-acid ligase inhibitor that inhibits the action of a D-alanine--D-alanine ligase (EC 6.3.2.4).
imported from: chebi.owl
has cross-reference: Wikipedia:D-alanine_ligase
has_obo_namespace: chebi_ontology
has_related_synonym: D-alanine--D-alanine ligase (EC 6.3.2.4) inhibitor
has_related_synonym: D-alanine--D-alanine ligase (EC 6.3.2.4) inhibitors
has_related_synonym: D-alanine--D-alanine ligase inhibitor
has_related_synonym: D-alanine--D-alanine ligase inhibitors
has_related_synonym: D-alanine:D-alanine ligase (ADP-forming) inhibitor
has_related_synonym: D-alanine:D-alanine ligase (ADP-forming) inhibitors
has_related_synonym: EC 6.3.2.4 (D-alanine--D-alanine ligase) inhibitors
has_related_synonym: EC 6.3.2.4 inhibitor
has_related_synonym: EC 6.3.2.4 inhibitors
has_related_synonym: alanine:alanine ligase (ADP-forming) inhibitor
has_related_synonym: alanine:alanine ligase (ADP-forming) inhibitors
has_related_synonym: alanylalanine synthetase inhibitor
has_related_synonym: alanylalanine synthetase inhibitors
id: CHEBI:75598
in subset: 3 STAR

EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor
type: Class
subclass of: EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor
textual definition: An acid--amino-acid ligase inhibitor that inhibits the action of a glutamate--cysteine ligase (EC 6.3.2.2)
imported from: chebi.owl
has cross-reference: Wikipedia:Glutamate-cysteine_ligase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.2.2 (glutamate--cysteine ligase) inhibitors
has_related_synonym: EC 6.3.2.2 inhibitor
has_related_synonym: EC 6.3.2.2 inhibitors
has_related_synonym: gamma-glutamyl-L-cysteine synthetase inhibitor
has_related_synonym: gamma-glutamyl-L-cysteine synthetase inhibitors
has_related_synonym: gamma-glutamylcysteine synthetase inhibitor
has_related_synonym: gamma-glutamylcysteine synthetase inhibitors
has_related_synonym: gamma-glutamylcysteinyl synthetase inhibitor
has_related_synonym: gamma-glutamylcysteinyl synthetase inhibitors
has_related_synonym: glutamate--cysteine ligase (EC 6.3.2.2) inhibitor
has_related_synonym: glutamate--cysteine ligase (EC 6.3.2.2) inhibitors
has_related_synonym: glutamate--cysteine ligase inhibitor
has_related_synonym: glutamate--cysteine ligase inhibitors
id: CHEBI:75599
in subset: 3 STAR

EC 6.3.* (C-N bond-forming ligase) inhibitor
type: Class
subclass of: EC 6.* (ligase) inhibitor
textual definition: A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C--N bond-forming ligase inhibitor
has_related_synonym: C--N bond-forming ligase inhibitors
has_related_synonym: C-N bond-forming ligase (EC 6.3.*) inhibitor
has_related_synonym: C-N bond-forming ligase (EC 6.3.*) inhibitors
has_related_synonym: C-N bond-forming ligase inhibitor
has_related_synonym: C-N bond-forming ligase inhibitors
has_related_synonym: EC 6.3.* (C-N bond-forming ligase) inhibitorS
has_related_synonym: EC 6.3.* inhibitor
has_related_synonym: EC 6.3.* inhibitors
has_related_synonym: EC 6.3.*.* inhibitor
has_related_synonym: EC 6.3.*.* inhibitors
id: CHEBI:75600
in subset: 3 STAR

EC 6.* (ligase) inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: Any enzyme inhibitor that interferes with the action of a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
imported from: chebi.owl
has cross-reference: Wikipedia:Ligase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.* (ligase) inhibitors
has_related_synonym: EC 6.* inhibitor
has_related_synonym: EC 6.* inhibitors
has_related_synonym: EC 6.*.*.* inhibitor
has_related_synonym: EC 6.*.*.* inhibitors
has_related_synonym: ligase inhibitor
has_related_synonym: ligase inhibitors
id: CHEBI:75603
in subset: 3 STAR

EC 6.4.* (C-C bond-forming ligase) inhibitor
type: Class
subclass of: EC 6.* (ligase) inhibitor
textual definition: A ligase inhibitor that interferes with the action of a C-C bond-forming ligase (EC 6.4.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C--C bond-forming ligase inhibitor
has_related_synonym: C--C bond-forming ligase inhibitors
has_related_synonym: C-C bond-forming ligase (EC 6.4.*) inhibitor
has_related_synonym: C-C bond-forming ligase (EC 6.4.*) inhibitorS
has_related_synonym: C-C bond-forming ligase inhibitor
has_related_synonym: C-C bond-forming ligase inhibitors
has_related_synonym: EC 6.4.* (C-C bond-forming ligase) inhibitorS
has_related_synonym: EC 6.4.* inhibitor
has_related_synonym: EC 6.4.* inhibitors
has_related_synonym: EC 6.4.*.* inhibitor
has_related_synonym: EC 6.4.*.* inhibitors
id: CHEBI:75604
in subset: 3 STAR

EC 6.5.* (phosphoric ester bond-forming ligase) inhibitor
type: Class
subclass of: EC 6.* (ligase) inhibitor
textual definition: A ligase inhibitor which inhibits the action of a phosphoric ester bond-forming ligase (EC 6.5.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.5.* (phosphoric ester bond-forming ligase) inhibitors
has_related_synonym: EC 6.5.* inhibitor
has_related_synonym: EC 6.5.* inhibitors
has_related_synonym: EC 6.5.*.* inhibitor
has_related_synonym: EC 6.5.*.* inhibitors
has_related_synonym: phosphoric ester bond-forming ligase (EC 6.5.*) inhibitor
has_related_synonym: phosphoric ester bond-forming ligase (EC 6.5.*) inhibitors
has_related_synonym: phosphoric ester bond-forming ligase inhibitor
has_related_synonym: phosphoric ester bond-forming ligase inhibitors
id: CHEBI:75605
in subset: 3 STAR

nifedipine
type: Class
subclass of: molecular entity
imported from: chebi.owl
charge: 0
formula: C17H18N2O6
inchi: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
inchikey: HYIMSNHJOBLJNT-UHFFFAOYSA-N
mass: 346.33460
monoisotopicmass: 346.11649
smiles: COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC
has cross-reference: Beilstein:497773
has cross-reference: CAS:21829-25-4
has cross-reference: DrugBank:DB01115
has cross-reference: Drug_Central:1922
has cross-reference: KEGG:C07266
has cross-reference: KEGG:D00437
has cross-reference: LINCS:LSM-4176
has cross-reference: Wikipedia:Nifedipine
alternative_term: Nifedipine
alternative_term: dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
has_obo_namespace: chebi_ontology
has_related_synonym: 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester
has_related_synonym: Adalat
has_related_synonym: Adapine
has_related_synonym: Coracten
has_related_synonym: Nifecard
has_related_synonym: Nifecor
has_related_synonym: Nifedipres
has_related_synonym: Procardia
has_related_synonym: nifedipine
has_related_synonym: nifedipino
has_related_synonym: nifedipinum
id: CHEBI:7565
in subset: 3 STAR

eukaryotic metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: eukaryotic metabolites
id: CHEBI:75763
in subset: 3 STAR

animal metabolite
type: Class
subclass of: eukaryotic metabolite
textual definition: Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
imported from: chebi.owl
has_alternative_id: CHEBI:77721
has_alternative_id: CHEBI:77743
has_obo_namespace: chebi_ontology
has_related_synonym: animal metabolites
id: CHEBI:75767
in subset: 3 STAR

mammalian metabolite
type: Class
subclass of: animal metabolite
textual definition: Any animal metabolite produced during a metabolic reaction in mammals.
imported from: chebi.owl
has_alternative_id: CHEBI:77464
has_alternative_id: CHEBI:77744
has_obo_namespace: chebi_ontology
has_related_synonym: mammalian metabolites
id: CHEBI:75768
in subset: 3 STAR

mouse metabolite
type: Class
subclass of: mammalian metabolite
textual definition: Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Mus musculus metabolite
has_related_synonym: Mus musculus metabolites
has_related_synonym: mouse metabolites
id: CHEBI:75771
in subset: 3 STAR

Saccharomyces cerevisiae metabolite
type: Class
subclass of: fungal metabolite
textual definition: Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
imported from: chebi.owl
has_alternative_id: CHEBI:76949
has_alternative_id: CHEBI:76951
has_obo_namespace: chebi_ontology
has_related_synonym: S. cerevisiae metabolite
has_related_synonym: S. cerevisiae metabolites
has_related_synonym: S. cerevisiae secondary metabolite
has_related_synonym: S. cerevisiae secondary metabolites
has_related_synonym: Saccharomyces cerevisiae metabolites
has_related_synonym: Saccharomyces cerevisiae secondary metabolites
has_related_synonym: baker's yeast metabolite
has_related_synonym: baker's yeast metabolites
has_related_synonym: baker's yeast secondary metabolite
has_related_synonym: baker's yeast secondary metabolites
id: CHEBI:75772
in subset: 3 STAR

prokaryotic metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: prokaryotic metabolites
id: CHEBI:75787
in subset: 3 STAR

anti-anaemic agent
type: Class
subclass of: application
textual definition: A compound which increases either the number of red cells or the amount of haemoglobin in the blood.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-anaemic agents
has_related_synonym: anti-anaemic drug
has_related_synonym: anti-anaemic drugs
has_related_synonym: anti-anemia agent
has_related_synonym: anti-anemia agents
has_related_synonym: anti-anemia drug
has_related_synonym: anti-anemia drugs
has_related_synonym: anti-anemic agent
has_related_synonym: anti-anemic agents
has_related_synonym: anti-anemic drug
has_related_synonym: anti-anemic drugs
has_related_synonym: antianaemia agent
has_related_synonym: antianaemia agents
has_related_synonym: antianaemia drug
has_related_synonym: antianaemia drugs
has_related_synonym: antianaemic agent
has_related_synonym: antianaemic agents
has_related_synonym: antianaemic drug
has_related_synonym: antianaemic drugs
has_related_synonym: antianemia drug
has_related_synonym: antianemia drugs
id: CHEBI:75835
in subset: 3 STAR

EC 6.3.2.19 (ubiquitin--protein ligase) inhibitor
type: Class
subclass of: EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor
textual definition: An enzyme inhibitor that interferes with the action of ubiquitin--protein ligase (EC 6.3.2.19).
imported from: chebi.owl
has cross-reference: Wikipedia:Ubiquitin_ligase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.2.19 (ubiquitin--protein ligase) inhibitors
has_related_synonym: EC 6.3.2.19 inhibitor
has_related_synonym: EC 6.3.2.19 inhibitors
has_related_synonym: S-phase kinase-associated protein 2 inhibitor
has_related_synonym: S-phase kinase-associated protein 2 inhibitors
has_related_synonym: Skp2 inhibitor
has_related_synonym: Skp2 inhibitors
has_related_synonym: ubiquitin--protein ligase inhibitor
has_related_synonym: ubiquitin--protein ligase inhibitors
has_related_synonym: ubiquitin-activating enzyme inhibitor
has_related_synonym: ubiquitin-activating enzyme inhibitors
has_related_synonym: ubiquitin:protein-lysine N-ligase (AMP-forming) inhibitor
has_related_synonym: ubiquitin:protein-lysine N-ligase (AMP-forming) inhibitors
id: CHEBI:75968
in subset: 3 STAR

soluble guanylate cyclase activator
type: Class
subclass of: enzyme activator
textual definition: Any compound that binds to and activates soluble guanylate cyclase (EC 4.6.1.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Soluble_guanylyl_cyclase
has_obo_namespace: chebi_ontology
has_related_synonym: sGC activator
has_related_synonym: sGC activators
has_related_synonym: soluble guanylate cyclase activators
has_related_synonym: soluble guanylyl cyclase activator
has_related_synonym: soluble guanylyl cyclase activators
id: CHEBI:76022
in subset: 3 STAR

xenobiotic metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite produced by metabolism of a xenobiotic compound.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: xenobiotic metabolites
id: CHEBI:76206
in subset: 3 STAR

fluorogen
type: Class
subclass of: biological role
textual definition: A non-fluorescent small compound which become fluorescent only when complexed to a fluorogen activating protein (FAP).
imported from: chebi.owl
has cross-reference: PMID:22135118
has cross-reference: PMID:22191699
has cross-reference: PMID:23325316
has cross-reference: PMID:23404950
has cross-reference: PMID:23506236
has_obo_namespace: chebi_ontology
id: CHEBI:76219
in subset: 3 STAR

EC 2.3.1.48 (histone acetyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48).
imported from: chebi.owl
has cross-reference: Wikipedia:Histone_acetyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.1.48 (histone acetyltransferase) inhibitors
has_related_synonym: EC 2.3.1.48 inhibitor
has_related_synonym: EC 2.3.1.48 inhibitors
has_related_synonym: HAT inhibitor
has_related_synonym: HAT inhibitors
has_related_synonym: acetyl-CoA:histone acetyltransferase inhibitor
has_related_synonym: acetyl-CoA:histone acetyltransferase inhibitors
has_related_synonym: histone acetokinase inhibitor
has_related_synonym: histone acetokinase inhibitors
has_related_synonym: histone acetylase inhibitor
has_related_synonym: histone acetylase inhibitors
has_related_synonym: histone acetyltransferase (EC 2.3.1.48) inhibitor
has_related_synonym: histone acetyltransferase (EC 2.3.1.48) inhibitors
has_related_synonym: histone acetyltransferase inhibitor
has_related_synonym: histone acetyltransferase inhibitors
has_related_synonym: histone transacetylase inhibitor
has_related_synonym: histone transacetylase inhibitors
has_related_synonym: nucleosome-histone acetyltransferase inhibitor
has_related_synonym: nucleosome-histone acetyltransferase inhibitors
id: CHEBI:76395
in subset: 3 STAR

greenhouse gas
type: Class
subclass of: chemical role
textual definition: A gas in an atmosphere that absorbs and emits radiation within the thermal infrared range, so contributing to the 'greenhouse effect'.
imported from: chebi.owl
has cross-reference: Wikipedia:Greenhouse_gas
has_obo_namespace: chebi_ontology
has_related_synonym: greenhouse gases
id: CHEBI:76413
in subset: 3 STAR

propellant
type: Class
subclass of: application
textual definition: A compressed gas or liquid with a boiling point lower than room temperature which to used to propel and dispense liquids such as deodorants, insecticides, paints, etc. from aerosol cans.
imported from: chebi.owl
has cross-reference: PMID:22519407
has cross-reference: PMID:24001847
has_obo_namespace: chebi_ontology
has_related_synonym: propellants
id: CHEBI:76414
in subset: 3 STAR

coral metabolite
type: Class
subclass of: animal metabolite
subclass of: marine metabolite
textual definition: Any animal metabolite produced during a metabolic reaction in corals (marine invertebrates).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: coral metabolites
id: CHEBI:76498
in subset: 3 STAR

marine metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
imported from: chebi.owl
has_alternative_id: CHEBI:77078
has_obo_namespace: chebi_ontology
has_related_synonym: marine metabolites
id: CHEBI:76507
in subset: 3 STAR

odorant receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the odorant receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: odorant receptor antagonists
has_related_synonym: odorant receptor blocker
has_related_synonym: odorant receptor blockers
id: CHEBI:76531
in subset: 3 STAR

nephroprotective agent
type: Class
subclass of: protective agent
textual definition: Any protective agent that is able to prevent damage to the kidney.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nephroprotective agents
id: CHEBI:76595
in subset: 3 STAR

EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
type: Class
subclass of: tyrosine kinase inhibitor
subclass of: EC 2.7.10.* (protein-tyrosine kinase) inhibitor
textual definition: An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
imported from: chebi.owl
has_alternative_id: CHEBI:66921
has cross-reference: Wikipedia:Janus_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ABL inhibitor
has_related_synonym: ABL inhibitors
has_related_synonym: ABL1 inhibitor
has_related_synonym: ABL1 inhibitors
has_related_synonym: ABL2 inhibitor
has_related_synonym: ABL2 inhibitors
has_related_synonym: ABLL inhibitor
has_related_synonym: ABLL inhibitors
has_related_synonym: ACK1 inhibitor
has_related_synonym: ACK1 inhibitors
has_related_synonym: ACK2 inhibitor
has_related_synonym: ACK2 inhibitors
has_related_synonym: AGMX1 inhibitor
has_related_synonym: AGMX1 inhibitors
has_related_synonym: ARG inhibitor
has_related_synonym: ARG inhibitors
has_related_synonym: ATK inhibitor
has_related_synonym: ATK inhibitors
has_related_synonym: ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) inhibitor
has_related_synonym: ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) inhibitors
has_related_synonym: BLK inhibitor
has_related_synonym: BLK inhibitors
has_related_synonym: BMX inhibitor
has_related_synonym: BMX inhibitors
has_related_synonym: BRK inhibitor
has_related_synonym: BRK inhibitors
has_related_synonym: BTK inhibitor
has_related_synonym: BTK inhibitors
has_related_synonym: BTKL inhibitor
has_related_synonym: BTKL inhibitors
has_related_synonym: Bmk inhibitor
has_related_synonym: Bmk inhibitors
has_related_synonym: Bruton's tyrosine kinase inhibitor
has_related_synonym: Bruton's tyrosine kinase inhibitors
has_related_synonym: Bsk inhibitor
has_related_synonym: Bsk inhibitors
has_related_synonym: CAKb inhibitor
has_related_synonym: CAKb inhibitors
has_related_synonym: CHK inhibitor
has_related_synonym: CHK inhibitors
has_related_synonym: CSK inhibitor
has_related_synonym: CSK inhibitors
has_related_synonym: CTK inhibitor
has_related_synonym: CTK inhibitors
has_related_synonym: CYL inhibitor
has_related_synonym: CYL inhibitors
has_related_synonym: Cdgip inhibitor
has_related_synonym: Cdgip inhibitors
has_related_synonym: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitors
has_related_synonym: EC 2.7.10.2 inhibitor
has_related_synonym: EC 2.7.10.2 inhibitors
has_related_synonym: EMT inhibitor
has_related_synonym: EMT inhibitors
has_related_synonym: ETK inhibitor
has_related_synonym: ETK inhibitors
has_related_synonym: FAK inhibitor
has_related_synonym: FAK inhibitors
has_related_synonym: FAK2 inhibitor
has_related_synonym: FAK2 inhibitors
has_related_synonym: FER inhibitor
has_related_synonym: FER inhibitors
has_related_synonym: FES inhibitor
has_related_synonym: FES inhibitors
has_related_synonym: FGR inhibitor
has_related_synonym: FGR inhibitors
has_related_synonym: FPS inhibitor
has_related_synonym: FPS inhibitors
has_related_synonym: FRK inhibitor
has_related_synonym: FRK inhibitors
has_related_synonym: FYN inhibitor
has_related_synonym: FYN inhibitors
has_related_synonym: Fadk inhibitor

fluorescence quencher
type: Class
subclass of: chemical role
textual definition: A compound used to return an excited fluorophore to the ground state by transfer of energy from fluorophore to quencher without the emission of light, with the quencher being promoted to its own excited state.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fluorescence quenchers
id: CHEBI:76648
in subset: 3 STAR

EC 2.1.* (C1-transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor inhibiting the action of transferase of a one-carbon-containing group (EC 2.1.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C1-transferase (EC 2.1.*) inhibitor
has_related_synonym: C1-transferase (EC 2.1.*) inhibitors
has_related_synonym: C1-transferase inhibitor
has_related_synonym: C1-transferase inhibitors
has_related_synonym: EC 2.1.* (C1-transferase) inhibitors
has_related_synonym: EC 2.1.* inhibitor
has_related_synonym: EC 2.1.* inhibitors
has_related_synonym: one-carbon-containing group transferase inhibitor
has_related_synonym: one-carbon-containing group transferase inhibitors
id: CHEBI:76655
in subset: 3 STAR

EC 2.2.* (aldehyde or ketone transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor interfering with the action of any transferase that transfers an aldehyde or ketone group (EC 2.2.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.2.* (aldehyde or ketone transferase) inhibitors
has_related_synonym: EC 2.2.* inhibitor
has_related_synonym: EC 2.2.* inhibitors
has_related_synonym: aldehyde or ketone transferase inhibitor
has_related_synonym: aldehyde or ketone transferase inhibitors
has_related_synonym: aldehyde/ketone transferase (EC 2.2.*) inhibitor
has_related_synonym: aldehyde/ketone transferase (EC 2.2.*) inhibitors
has_related_synonym: aldehyde/ketone transferase inhibitor
has_related_synonym: aldehyde/ketone transferase inhibitors
id: CHEBI:76660
in subset: 3 STAR

EC 2.3.* (acyltransferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor that interferes with the action of an acyltransferase (EC 2.3.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.* (acyltransferase) inhibitors
has_related_synonym: EC 2.3.* inhibitor
has_related_synonym: EC 2.3.* inhibitors
has_related_synonym: acyltransferase inhibitor
has_related_synonym: acyltransferase inhibitors
id: CHEBI:76661
in subset: 3 STAR

EC 2.4.* (glycosyltransferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor inhibiting the action of a glycosyltransferase (EC 2.4.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.* (glycosyltransferase) inhibitors
has_related_synonym: EC 2.4.* inhibitor
has_related_synonym: EC 2.4.* inhibitors
has_related_synonym: glycosyltransferase (EC 2.4.*) inhibitor
has_related_synonym: glycosyltransferase (EC 2.4.*) inhibitors
has_related_synonym: glycosyltransferase inhibitor
has_related_synonym: glycosyltransferase inhibitors
id: CHEBI:76662
in subset: 3 STAR

EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
type: Class
subclass of: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors
has_related_synonym: EC 2.5.1.* inhibitor
has_related_synonym: EC 2.5.1.* inhibitors
has_related_synonym: alkyl/aryl (non-methyl) transferase inhibitor
has_related_synonym: alkyl/aryl (non-methyl) transferase inhibitors
has_related_synonym: non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor
has_related_synonym: non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors
has_related_synonym: non-methyl alkyl/aryl transferase inhibitor
has_related_synonym: non-methyl alkyl/aryl transferase inhibitors
has_related_synonym: non-methyl-alkyl or aryl transferase inhibitor
has_related_synonym: non-methyl-alkyl or aryl transferase inhibitors
id: CHEBI:76663
in subset: 3 STAR

EC 2.6.* (nitrogenous group transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor that inhibits a nitrogenous group transferase (EC 2.6.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.6.* inhibitor
has_related_synonym: EC 2.6.* inhibitors
has_related_synonym: nitrogenous group transferase (EC 2.6.*) inhibitor
has_related_synonym: nitrogenous group transferase (EC 2.6.*) inhibitors
has_related_synonym: nitrogenous group transferase inhibitor
has_related_synonym: nitrogenous group transferase inhibitors
id: CHEBI:76665
in subset: 3 STAR

EC 2.7.* (P-containing group transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.* (P-containing group transferase) inhibitors
has_related_synonym: EC 2.7.* (phosphorus-containing group transferase) inhibitor
has_related_synonym: EC 2.7.* (phosphorus-containing group transferase) inhibitors
has_related_synonym: EC 2.7.* inhibitor
has_related_synonym: EC 2.7.* inhibitors
has_related_synonym: phosphorus-containing group transferase (EC 2.7.*) inhibitor
has_related_synonym: phosphorus-containing group transferase (EC 2.7.*) inhibitors
has_related_synonym: phosphorus-containing group transferase inhibitor
has_related_synonym: phosphorus-containing group transferase inhibitors
id: CHEBI:76668
in subset: 3 STAR

EC 2.8.* (S-containing group transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor that interferes with the action of a sulfur-containing group transferase (EC 2.8.*.*).
imported from: chebi.owl
alternative_term: EC 2.8.* (S-containing group transferase) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.8.* (S-containing group transferase) inhibitors
has_related_synonym: EC 2.8.* inhibitor
has_related_synonym: EC 2.8.* inhibitors
has_related_synonym: S-containing group transferase inhibitor
has_related_synonym: S-containing group transferase inhibitors
has_related_synonym: sulfur-containing group transferase (EC 2.8.*) inhibitor
has_related_synonym: sulfur-containing group transferase (EC 2.8.*) inhibitors
has_related_synonym: sulfur-containing group transferase inhibitor
has_related_synonym: sulfur-containing group transferase inhibitors
id: CHEBI:76676
in subset: 3 STAR

EC 2.9.* (Se-containing group transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor that interferes with the action of a selenium-containing group transferase (EC 2.9.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.9.* (Se-containing group transferase) inhibitors
has_related_synonym: EC 2.9.* inhibitor
has_related_synonym: EC 2.9.* inhibitors
has_related_synonym: Se-containing group transferase inhibitor
has_related_synonym: Se-containing group transferase inhibitors
has_related_synonym: selenium-containing group transferase (EC 2.9.*) inhibitor
has_related_synonym: selenium-containing group transferase (EC 2.9.*) inhibitors
has_related_synonym: selenium-containing group transferase inhibitor
has_related_synonym: selenium-containing group transferase inhibitors
id: CHEBI:76677
in subset: 3 STAR

EC 2.10.* (Mo- or W-containing group transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: A transferase inhibitor that interferes with the action of a molybdenum- or tungsten-containing group transferase (EC 2.10.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.10.* (Mo- or W-containing group transferase) inhibitors
has_related_synonym: EC 2.10.* inhibitor
has_related_synonym: EC 2.10.* inhibitors
has_related_synonym: Mo- or W-containing group transferase (EC 2.10.*) inhibitor
has_related_synonym: Mo- or W-containing group transferase (EC 2.10.*) inhibitors
has_related_synonym: Mo- or W-containing group transferase inhibitor
has_related_synonym: Mo- or W-containing group transferase inhibitors
id: CHEBI:76681
in subset: 3 STAR

EC 5.1.* (racemase/epimerase) inhibitor
type: Class
subclass of: EC 5.* (isomerase) inhibitor
textual definition: An isomerase inhibitor interfering with the action of a racemase or epimerase (EC 5.1.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.1.* (racemase/epimerase) inhibitors
has_related_synonym: EC 5.1.* inhibitor
has_related_synonym: EC 5.1.* inhibitors
has_related_synonym: racemase and epimerase (EC 5.1*) inhibitor
has_related_synonym: racemase and epimerase (EC 5.1*) inhibitors
has_related_synonym: racemase and epimerase inhibitor
has_related_synonym: racemase and epimerase inhibitors
has_related_synonym: racemase/epimerase inhibitor
has_related_synonym: racemase/epimerase inhibitors
id: CHEBI:76692
in subset: 3 STAR

EC 5.2.* (cis-trans-isomerase) inhibitor
type: Class
subclass of: EC 5.* (isomerase) inhibitor
textual definition: An isomerase inhibitor interfering with the action of a cis-trans-isomerase (EC 5.2.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.2.* (cis-trans-isomerase) inhibitors
has_related_synonym: EC 5.2.* inhibitor
has_related_synonym: EC 5.2.* inhibitors
has_related_synonym: cis-trans-isomerase (EC5.2.*) inhibitor
has_related_synonym: cis-trans-isomerase (EC5.2.*) inhibitors
has_related_synonym: cis-trans-isomerase inhibitor
has_related_synonym: cis-trans-isomerase inhibitors
id: CHEBI:76693
in subset: 3 STAR

EC 5.3.* (intramolecular oxidoreductase) inhibitor
type: Class
subclass of: EC 5.* (isomerase) inhibitor
textual definition: An isomerase inhibitor that interferes with the action of an intramolecular oxidoreductase (EC 5.3.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.3.* (intramolecular oxidoreductase) inhibitors
has_related_synonym: intramolecular oxidoreductase (EC 5.3.*) inhibitor
has_related_synonym: intramolecular oxidoreductase (EC 5.3.*) inhibitors
has_related_synonym: intramolecular oxidoreductase inhibitor
has_related_synonym: intramolecular oxidoreductase inhibitors
id: CHEBI:76694
in subset: 3 STAR

EC 5.4.* (intramolecular transferase) inhibitor
type: Class
subclass of: EC 5.* (isomerase) inhibitor
textual definition: An isomerase inhibitor that interferes with the action of an intramolecular transferase (EC 5.4.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.4.* (intramolecular transferase) inhibitors
has_related_synonym: intramolecular transferase (EC 5.4.*) inhibitor
has_related_synonym: intramolecular transferase (EC 5.4.*) inhibitors
has_related_synonym: intramolecular transferase inhibitor
has_related_synonym: intramolecular transferase inhibitors
id: CHEBI:76695
in subset: 3 STAR

EC 5.5.* (intramolecular lyase) inhibitor
type: Class
subclass of: EC 5.* (isomerase) inhibitor
textual definition: An isomerase inhibitor that interferes with the action of an intramolecular lyase (EC 5.5.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.5.* (intramolecular lyase) inhibitors
has_related_synonym: EC 5.5.* inhibitor
has_related_synonym: EC 5.5.* inhibitors
has_related_synonym: intramolecular lyase inhibitor
has_related_synonym: intramolecular lyase inhibitors
id: CHEBI:76696
in subset: 3 STAR

EC 5.99.* (other isomerases) inhibitor
type: Class
subclass of: EC 5.* (isomerase) inhibitor
textual definition: An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.99.* (miscellaneous isomerases) inhibitor
has_related_synonym: EC 5.99.* (miscellaneous isomerases) inhibitors
has_related_synonym: EC 5.99.* (other isomerase) inhibitor
has_related_synonym: EC 5.99.* (other isomerase) inhibitors
has_related_synonym: EC 5.99.* (other isomerases) inhibitors
has_related_synonym: EC 5.99.* inhibitor
has_related_synonym: EC 5.99.* inhibitors
id: CHEBI:76697
in subset: 3 STAR

EC 6.1.* (C-O bond-forming ligase) inhibitor
type: Class
subclass of: EC 6.* (ligase) inhibitor
textual definition: A ligase inhibitor that interferes with the action of a C-O bond-forming ligase (EC 6.1.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-O bond-forming ligase (EC 6.1.*) inhibitor
has_related_synonym: C-O bond-forming ligase (EC 6.1.*) inhibitors
has_related_synonym: C-O bond-forming ligase inhibitor
has_related_synonym: C-O bond-forming ligase inhibitors
has_related_synonym: EC 6.1.* (C-O bond-forming ligase) inhibitors
has_related_synonym: EC 6.1.* inhibitor
has_related_synonym: EC 6.1.* inhibitors
id: CHEBI:76706
in subset: 3 STAR

EC 6.2.* (C-S bond-forming ligase) inhibitor
type: Class
subclass of: EC 6.* (ligase) inhibitor
textual definition: A ligase inhibitor that interferes with the action of a C-S bond-forming ligase (EC 6.2.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-S bond-forming ligase (EC 6.2.*) inhibitor
has_related_synonym: C-S bond-forming ligase (EC 6.2.*) inhibitors
has_related_synonym: C-S bond-forming ligase inhibitor
has_related_synonym: C-S bond-forming ligase inhibitors
has_related_synonym: EC 6.2.* (C-S bond-forming ligase) inhibitors
has_related_synonym: EC 6.2.* inhibitor
has_related_synonym: EC 6.2.* inhibitors
id: CHEBI:76707
in subset: 3 STAR

EC 6.6.* (N-metal bond-forming ligase) inhibitor
type: Class
subclass of: EC 6.* (ligase) inhibitor
textual definition: A ligase inhibitor which interferes with the action of a nitrogen-metal bond-forming ligase (EC 6.6.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.6.* (N-metal bond-forming ligase) inhibitors
has_related_synonym: EC 6.6.* inhibitor
has_related_synonym: EC 6.6.* inhibitors
has_related_synonym: N-metal bond-forming ligase (EC 6.6.*) inhibitor
has_related_synonym: N-metal bond-forming ligase (EC 6.6.*) inhibitors
has_related_synonym: N-metal bond-forming ligase inhibitor
has_related_synonym: N-metal bond-forming ligase inhibitors
id: CHEBI:76708
in subset: 3 STAR

EC 4.* (lyase) inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: An enzyme inhibitor which interferes with the action of a lyase (EC 4.*.*.*). Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation.
imported from: chebi.owl
has cross-reference: Wikipedia:Lyase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.* (lyase) inhibitors
has_related_synonym: EC 4.* inhibitor
has_related_synonym: EC 4.* inhibitors
has_related_synonym: EC 4.*.*.* inhibitor
has_related_synonym: EC 4.*.*.* inhibitors
has_related_synonym: lyase (EC 4.*) inhibitor
has_related_synonym: lyase (EC 4.*) inhibitorS
has_related_synonym: lyase inhibitor
has_related_synonym: lyase inhibitors
id: CHEBI:76710
in subset: 3 STAR

EC 4.1.* (C-C lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which inhibits the action of a C-C lyase (EC 4.1.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-C lyase (EC 4.1.*) inhibitor
has_related_synonym: C-C lyase (EC 4.1.*) inhibitors
has_related_synonym: C-C lyase inhibitor
has_related_synonym: C-C lyase inhibitors
has_related_synonym: EC 4.1.* (C-C lyase) inhibitors
has_related_synonym: EC 4.1.* inhibitor
has_related_synonym: EC 4.1.* inhibitors
id: CHEBI:76711
in subset: 3 STAR

EC 4.2.* (C-O lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which inhibits the action of a C-O lyase (EC 4.2.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-O lyase (EC 4.2.*) inhibitor
has_related_synonym: C-O lyase (EC 4.2.*) inhibitors
has_related_synonym: C-O lyase inhibitor
has_related_synonym: C-O lyase inhibitors
has_related_synonym: EC 4.2.* (C-O lyase) inhibitors
has_related_synonym: EC 4.2.* inhibitor
has_related_synonym: EC 4.2.* inhibitors
id: CHEBI:76712
in subset: 3 STAR

EC 4.3.* (C-N lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which inhibits the action of a C-N lyase (EC 4.3.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-N lyase (EC 4.3.*) inhibitor
has_related_synonym: C-N lyase (EC 4.3.*) inhibitors
has_related_synonym: C-N lyase inhibitor
has_related_synonym: C-N lyase inhibitors
has_related_synonym: EC 4.3.* (C-N lyase) inhibitors
has_related_synonym: EC 4.3.* inhibitor
has_related_synonym: EC 4.3.* inhibitors
id: CHEBI:76713
in subset: 3 STAR

EC 4.4.* (C-S lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which inhibits the action of a C-S lyase (EC 4.4.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-S lyase (EC 4.4.*) inhibitor
has_related_synonym: C-S lyase (EC 4.4.*) inhibitors
has_related_synonym: C-S lyase inhibitor
has_related_synonym: C-S lyase inhibitors
has_related_synonym: EC 4.4.* (C-S lyase) inhibitors
has_related_synonym: EC 4.4.* inhibitor
has_related_synonym: EC 4.4.* inhibitors
id: CHEBI:76714
in subset: 3 STAR

EC 4.5.* (C-halide lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which inhibits the action of a C-halide lyase (EC 4.5.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-halide lyase (EC 4.5.*) inhibitor
has_related_synonym: C-halide lyase (EC 4.5.*) inhibitors
has_related_synonym: C-halide lyase inhibitor
has_related_synonym: C-halide lyase inhibitors
has_related_synonym: EC 4.5.* (C-halide lyase) inhibitors
has_related_synonym: EC 4.5.* inhibitor
has_related_synonym: EC 4.5.* inhibitors
id: CHEBI:76715
in subset: 3 STAR

EC 4.6.* (P-O lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which inhibits the action of a P-O lyase (EC 4.6.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.6.* (P-O lyase) inhibitors
has_related_synonym: EC 4.6.* inhibitor
has_related_synonym: EC 4.6.* inhibitors
has_related_synonym: P-O lyase (EC 4.6.*) inhibitor
has_related_synonym: P-O lyase (EC 4.6.*) inhibitors
has_related_synonym: P-O lyase inhibitor
has_related_synonym: P-O lyase inhibitors
id: CHEBI:76716
in subset: 3 STAR

EC 4.7.* (C-P lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which inhibits the action of a C-P lyase (EC 4.6.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-P lyase (EC 4.7.*) inhibitor
has_related_synonym: C-P lyase (EC 4.7.*) inhibitors
has_related_synonym: C-P lyase inhibitor
has_related_synonym: C-P lyase inhibitors
has_related_synonym: EC 4.7.* (C-P lyase) inhibitors
has_related_synonym: EC 4.7.* inhibitor
has_related_synonym: EC 4.7.* inhibitors
id: CHEBI:76717
in subset: 3 STAR

EC 4.99.* (miscellaneous lyase) inhibitor
type: Class
subclass of: EC 4.* (lyase) inhibitor
textual definition: A lyase inhibitor which interferes with the activity of a lyase in the EC 4.99.*.* group.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.99.* (miscellaneous lyase) inhibitors
has_related_synonym: EC 4.99.* (other lyase) inhibitor
has_related_synonym: EC 4.99.* (other lyase) inhibitors
has_related_synonym: EC 4.99.* inhibitor
has_related_synonym: EC 4.99.* inhibitors
has_related_synonym: miscellaneous lyase (EC 4.99.*) inhibitor
has_related_synonym: miscellaneous lyase (EC 4.99.*) inhibitors
has_related_synonym: miscellaneous lyase inhibitor
has_related_synonym: miscellaneous lyase inhibitors
has_related_synonym: other lyase (EC 4.99.*) inhibitor
has_related_synonym: other lyase (EC 4.99.*) inhibitors
id: CHEBI:76718
in subset: 3 STAR

antisense oligonucleotide
type: Class
subclass of: biochemical role
textual definition: A synthetic oligonucleotide whose base sequence is complementary to a gene's messenger RNA (mRNA) and which will bind with the mRNA inactivating it.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:76720
in subset: 3 STAR

EC 1.* (oxidoreductase) inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*).
imported from: chebi.owl
has cross-reference: Wikipedia:Oxidoreductase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.* (oxidoreductase) inhibitors
has_related_synonym: EC 1.* inhibitor
has_related_synonym: EC 1.* inhibitors
has_related_synonym: oxidoreductase (EC 1.*) inhibitor
has_related_synonym: oxidoreductase (EC 1.*) inhibitors
has_related_synonym: oxidoreductase inhibitor
has_related_synonym: oxidoreductase inhibitors
id: CHEBI:76725
in subset: 3 STAR

EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors
has_related_synonym: EC 1.1.* inhibitor
has_related_synonym: EC 1.1.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-OH group of donor
has_related_synonym: inhibitor of oxidoreductase acting on CH-OH group of donors
has_related_synonym: inhibitors of oxidoreductase acting on CH-OH group of donor
has_related_synonym: inhibitors of oxidoreductase acting on CH-OH group of donors
has_related_synonym: oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors
has_related_synonym: oxidoreductase acting on donor CH-OH group inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group inhibitors
id: CHEBI:76726
in subset: 3 STAR

EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the aldehyde or oxo group of donors (EC 1.2.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor
has_related_synonym: EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors
has_related_synonym: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors
has_related_synonym: EC 1.2.* inhibitor
has_related_synonym: EC 1.2.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde or oxo group of donor
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde or oxo group of donors
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde/oxo group of donor
has_related_synonym: inhibitor of oxidoreductase acting on aldehyde/oxo group of donors
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde or oxo group of donor
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde or oxo group of donors
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde/oxo group of donor
has_related_synonym: inhibitors of oxidoreductase acting on aldehyde/oxo group of donors
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde or oxo group inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group inhibitors
id: CHEBI:76727
in subset: 3 STAR

EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors
has_related_synonym: EC 1.3.* inhibitor
has_related_synonym: EC 1.3.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH group of donor
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH group of donors
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH group of donor
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH group of donors
has_related_synonym: oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors
has_related_synonym: oxidoreductase acting on donor CH-CH group inhibitor
has_related_synonym: oxidoreductase acting on donor CH-CH group inhibitors
id: CHEBI:76729
in subset: 3 STAR

EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH2 group of donors (EC 1.4.*.*).
imported from: chebi.owl
alternative_term: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitors
has_related_synonym: EC 1.4.* inhibitor
has_related_synonym: EC 1.4.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-NH2 group of donor
has_related_synonym: inhibitor of oxidoreductase acting on CH-NH2 group of donors
has_related_synonym: inhibitors of oxidoreductase acting on CH-NH2 group of donor
has_related_synonym: inhibitors of oxidoreductase acting on CH-NH2 group of donors
has_related_synonym: oxidoreductase acting on CH-NH2 group of donor inhibitor
has_related_synonym: oxidoreductase acting on CH-NH2 group of donor inhibitors
has_related_synonym: oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitor
has_related_synonym: oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitors
id: CHEBI:76730
in subset: 3 STAR

EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors
has_related_synonym: EC 1.5.* inhibitor
has_related_synonym: EC 1.5.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-NH group of donor
has_related_synonym: inhibitor of oxidoreductase acting on CH-NH group of donors
has_related_synonym: inhibitors of oxidoreductase acting on CH-NH group of donor
has_related_synonym: inhibitors of oxidoreductase acting on CH-NH group of donors
has_related_synonym: oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors
id: CHEBI:76731
in subset: 3 STAR

EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on NADH or NADPH (EC 1.6.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on NADH or NADPH
has_related_synonym: inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*)
has_related_synonym: inhibitors of oxidoreductase acting on NADH or NADPH
has_related_synonym: inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*)
has_related_synonym: oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor
has_related_synonym: oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors
has_related_synonym: oxidoreductase acting on NADH or NADPH inhibitor
has_related_synonym: oxidoreductase acting on NADH or NADPH inhibitors
id: CHEBI:76733
in subset: 3 STAR

EC 1.7.* (oxidoreductase acting on other nitrogenous compounds as donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase of class EC 1.7.*.* (acting on other nitrogenous compounds as donors).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.7.* (oxidoreductase acting on other nitrogenous compounds as donors) inhibitors
has_related_synonym: EC 1.7.* inhibitor
has_related_synonym: EC 1.7.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on other nitrogenous compounds as donors
has_related_synonym: inhibitor of oxidoreductase acting on other nitrogenous compounds as donors (EC 1.7.*)
has_related_synonym: inhibitors of oxidoreductase acting on other nitrogenous compounds as donors
has_related_synonym: inhibitors of oxidoreductase acting on other nitrogenous compounds as donors (EC 1.7.*)
id: CHEBI:76734
in subset: 3 STAR

EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase of class EC 1.8.*.* (acting on a sulfur group of donors).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors
has_related_synonym: EC 1.8.* inhibitor
has_related_synonym: EC 1.8.* inhibitors
has_related_synonym: oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor
has_related_synonym: oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors
id: CHEBI:76735
in subset: 3 STAR

EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on a heme group of donors (EC 1.9.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitor
has_related_synonym: EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitors
has_related_synonym: EC 1.9.* (oxidoreductase acting on donor heme group) inhibitors
has_related_synonym: EC 1.9.* inhibitor
has_related_synonym: EC 1.9.* inhibitors
has_related_synonym: oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitor
has_related_synonym: oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitors
id: CHEBI:76736
in subset: 3 STAR

EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on diphenols and related substances as donors (EC 1.10.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitors
has_related_synonym: EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitor
has_related_synonym: EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitors
has_related_synonym: EC 1.10.* inhibitor
has_related_synonym: EC 1.10.* inhibitors
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donor
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donors
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donor
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donors
id: CHEBI:76737
in subset: 3 STAR

EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on peroxide as donors (EC 1.11.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitors
has_related_synonym: EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitor
has_related_synonym: EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitors
has_related_synonym: EC 1.11.* inhibitor
has_related_synonym: EC 1.11.* inhibitors
has_related_synonym: oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitor
has_related_synonym: oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitors
has_related_synonym: oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitor
has_related_synonym: oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitors
id: CHEBI:76738
in subset: 3 STAR

EC 1.12.* (oxidoreductase acting on hydrogen as donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.12.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.12.* (oxidoreductase acting on hydrogen as donors) inhibitors
has_related_synonym: EC 1.12.* (oxidoreductases acting on hydrogen as donors) inhibitor
has_related_synonym: EC 1.12.* (oxidoreductases acting on hydrogen as donors) inhibitors
has_related_synonym: EC 1.12.* inhibitor
has_related_synonym: EC 1.12.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on hydrogen as donors
has_related_synonym: inhibitor of oxidoreductase acting on hydrogen as donors (EC 1.12.*)
has_related_synonym: inhibitors of oxidoreductase acting on hydrogen as donors
has_related_synonym: inhibitors of oxidoreductase acting on hydrogen as donors (EC 1.12.*)
has_related_synonym: oxidoreductase acting on hydrogen as donors inhibitor
has_related_synonym: oxidoreductase acting on hydrogen as donors inhibitors
id: CHEBI:76739
in subset: 3 STAR

EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases), EC 1.13.*.*.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors
has_related_synonym: EC 1.13.* inhibitor
has_related_synonym: EC 1.13.* inhibitors
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor
has_related_synonym: oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors
id: CHEBI:76740
in subset: 3 STAR

EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.14.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors
has_related_synonym: EC 1.14.* inhibitor
has_related_synonym: EC 1.14.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors
id: CHEBI:76741
in subset: 3 STAR

EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on superoxide as acceptor (EC 1.15.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitors
has_related_synonym: EC 1.15.* inhibitor
has_related_synonym: EC 1.15.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on superoxide as acceptor
has_related_synonym: inhibitor of oxidoreductase acting on superoxide as acceptor (EC 1.15.*)
has_related_synonym: inhibitors of oxidoreductase acting on superoxide as acceptor
has_related_synonym: inhibitors of oxidoreductase acting on superoxide as acceptor (EC 1.15.*)
has_related_synonym: oxidoreductase acting on superoxide as acceptor (EC 1.15.*) inhibitor
has_related_synonym: oxidoreductase acting on superoxide as acceptor (EC 1.15.*) inhibitors
has_related_synonym: oxidoreductase acting on superoxide as acceptor inhibitor
has_related_synonym: oxidoreductase acting on superoxide as acceptor inhibitors
id: CHEBI:76742
in subset: 3 STAR

EC 1.16.* (oxidoreductase oxidising metal ions) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase oxidising metal ions (EC 1.16.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.16.* (oxidoreductase oxidising metal ions) inhibitors
has_related_synonym: EC 1.16.* (oxidoreductase oxidizing metal ions) inhibitor
has_related_synonym: EC 1.16.* (oxidoreductase oxidizing metal ions) inhibitors
has_related_synonym: EC 1.16.* inhibitor
has_related_synonym: EC 1.16.* inhibitors
has_related_synonym: oxidoreductase oxidising metal ions (EC 1.16.*) inhibitor
has_related_synonym: oxidoreductase oxidising metal ions (EC 1.16.*) inhibitors
has_related_synonym: oxidoreductase oxidising metal ions inhibitor
has_related_synonym: oxidoreductase oxidising metal ions inhibitors
has_related_synonym: oxidoreductase oxidizing metal ions (EC 1.16.*) inhibitor
has_related_synonym: oxidoreductase oxidizing metal ions (EC 1.16.*) inhibitors
has_related_synonym: oxidoreductase oxidizing metal ions inhibitor
has_related_synonym: oxidoreductase oxidizing metal ions inhibitors
id: CHEBI:76743
in subset: 3 STAR

EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on CH or CH2 (EC 1.17.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors
has_related_synonym: EC 1.17.* inhibitor
has_related_synonym: EC 1.17.* inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 inhibitors
id: CHEBI:76744
in subset: 3 STAR

EC 1.18.* (oxidoreductase acting on Fe-S proteins as donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on iron-sulfur proteins as donors (EC 1.18.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.18.* (oxidoreductase acting on Fe-S proteins as donors) inhibitors
has_related_synonym: EC 1.18.* (oxidoreductase acting on iron-sulfur proteins as donors) inhibitor
has_related_synonym: EC 1.18.* (oxidoreductase acting on iron-sulfur proteins as donors) inhibitors
has_related_synonym: EC 1.18.* inhibitor
has_related_synonym: EC 1.18.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on Fe-S proteins as donors
has_related_synonym: inhibitor of oxidoreductase acting on iron-sulfur proteins as donors
has_related_synonym: inhibitors of oxidoreductase acting on Fe-S proteins as donors
has_related_synonym: inhibitors of oxidoreductase acting on iron-sulfur proteins as donors
has_related_synonym: inhibitors of oxidoreductases acting on iron-sulfur proteins as donors
has_related_synonym: oxidoreductase acting on Fe-S proteins as donors (EC 1.18.*) inhibitor
has_related_synonym: oxidoreductase acting on Fe-S proteins as donors (EC 1.18.*) inhibitors
has_related_synonym: oxidoreductase acting on iron-sulfur proteins as donors (EC 1.18.*) inhibitor
has_related_synonym: oxidoreductase acting on iron-sulfur proteins as donors (EC 1.18.*) inhibitors
id: CHEBI:76745
in subset: 3 STAR

EC 1.19.* (oxidoreductase acting on reduced flavodoxin as donor) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.19.* (oxidoreductase acting on reduced flavodoxin as donor) inhibitors
has_related_synonym: EC 1.19.* inhibitor
has_related_synonym: EC 1.19.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on reduced flavodoxin as donor
has_related_synonym: inhibitor of oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*)
has_related_synonym: inhibitors of oxidoreductase acting on reduced flavodoxin as donor
has_related_synonym: inhibitors of oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*)
has_related_synonym: oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*) inhibitor
has_related_synonym: oxidoreductase acting on reduced flavodoxin as donor (EC 1.19.*) inhibitors
id: CHEBI:76746
in subset: 3 STAR

EC 1.20.* (oxidoreductase acting on P or As in donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on phosphorus or arsenic in donors (EC 1.20.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.20.* (oxidoreductase acting on P or As in donors) inhibitors
has_related_synonym: EC 1.20.* (oxidoreductase acting on phosphorus or arsenic in donors) inhibitor
has_related_synonym: EC 1.20.* (oxidoreductase acting on phosphorus or arsenic in donors) inhibitors
has_related_synonym: EC 1.20.* inhibitor
has_related_synonym: EC 1.20.* inhibitors
has_related_synonym: oxidoreductase acting on P or As in donors (EC 1.20.*) inhibitor
has_related_synonym: oxidoreductase acting on P or As in donors (EC 1.20.*) inhibitors
has_related_synonym: oxidoreductase acting on phosphorus or arsenic in donors (EC 1.20.*) inhibitor
has_related_synonym: oxidoreductase acting on phosphorus or arsenic in donors (EC 1.20.*) inhibitors
id: CHEBI:76747
in subset: 3 STAR

EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on X-H and Y-H to form an X-Y bond (EC 1.21.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitors
has_related_synonym: EC 1.21.* inhibitor
has_related_synonym: EC 1.21.* inhibitors
has_related_synonym: oxidoreductase acting on X-H and Y-H to form an X-Y bond (EC 1.21.*) inhibitor
has_related_synonym: oxidoreductase acting on X-H and Y-H to form an X-Y bond (EC 1.21.*) inhibitors
has_related_synonym: oxidoreductase acting on X-H and Y-H to form an X-Y bond inhibitor
has_related_synonym: oxidoreductase acting on X-H and Y-H to form an X-Y bond inhibitors
id: CHEBI:76748
in subset: 3 STAR

EC 1.22.* (oxidoreductase acting on halogen in donors) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on halogen in donors (EC 1.22.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.22.* (oxidoreductase acting on halogen in donors) inhibitors
has_related_synonym: EC 1.22.* inhibitor
has_related_synonym: EC 1.22.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on halogen in donors
has_related_synonym: inhibitor of oxidoreductase acting on halogen in donors (EC 1.22.*)
has_related_synonym: inhibitors of oxidoreductase acting on halogen in donors
has_related_synonym: inhibitors of oxidoreductase acting on halogen in donors (EC 1.22.*)
has_related_synonym: oxidoreductase acting on halogen in donors (EC 1.22.*) inhibitor
has_related_synonym: oxidoreductase acting on halogen in donors (EC 1.22.*) inhibitors
id: CHEBI:76750
in subset: 3 STAR

EC 1.23.* (oxidoreductase acting on C-O-C group as acceptor) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.23.* (oxidoreductase acting on C-O-C group as acceptor) inhibitors
has_related_synonym: EC 1.23.* inhibitor
has_related_synonym: EC 1.23.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on C-O-C group as acceptor
has_related_synonym: inhibitor of oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*)
has_related_synonym: inhibitors of oxidoreductase acting on C-O-C group as acceptor
has_related_synonym: inhibitors of oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*)
has_related_synonym: oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*) inhibitor
has_related_synonym: oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*) inhibitors
has_related_synonym: oxidoreductase acting on C-O-C group as acceptor inhibitor
has_related_synonym: oxidoreductase acting on C-O-C group as acceptor inhibitors
id: CHEBI:76752
in subset: 3 STAR

EC 1.97.* (other oxidoreductase) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of any oxidoreductase that is classified as EC 1.97.*.*, (those oxidoreductases not included in any other EC 1.* category).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.97.* (miscellaneous oxidoreductase) inhibitor
has_related_synonym: EC 1.97.* (miscellaneous oxidoreductase) inhibitors
has_related_synonym: EC 1.97.* (other oxidoreductase) inhibitors
has_related_synonym: EC 1.97.* inhibitor
has_related_synonym: EC 1.97.* inhibitors
has_related_synonym: inhibitor of 'other' oxidoreductase (EC 1.97.*)
has_related_synonym: inhibitor of miscellaneous oxidoreductase (EC 1.97.*)
has_related_synonym: inhibitors of 'other' oxidoreductase (EC 1.97.*)
has_related_synonym: inhibitors of miscellaneous oxidoreductase (EC 1.97.*)
id: CHEBI:76753
in subset: 3 STAR

EC 1.98.* (enzymes using H2 as reductant) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of any oxidoreductase using H2 as reductant (EC 1.98.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.98.* (enzymes using H2 as reductant) inhibitors
has_related_synonym: EC 1.98.* inhibitor
has_related_synonym: EC 1.98.* inhibitors
has_related_synonym: inhibitor of enzymes using H2 as reductant (EC 1.98.*)
has_related_synonym: inhibitors of enzymes using H2 as reductant (EC 1.98.*)
id: CHEBI:76755
in subset: 3 STAR

EC 1.99.* (other oxidoreductases using O2 as oxidant) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
textual definition: An oxidoreductase inhibitor which interferes with the action of any oxidoreductase that is classified as EC 1.99.*.* (other oxidoreductases using O2 as oxidant).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.99.* (other oxidoreductases using O2 as oxidant) inhibitors
has_related_synonym: EC 1.99.* inhibitor
has_related_synonym: EC 1.99.* inhibitors
id: CHEBI:76757
in subset: 3 STAR

EC 3.* (hydrolase) inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
imported from: chebi.owl
has cross-reference: Wikipedia:Hydrolase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.* (hydrolase) inhibitors
has_related_synonym: EC 3.* inhibitor
has_related_synonym: EC 3.* inhibitors
has_related_synonym: EC 3.*.*.* inhibitor
has_related_synonym: EC 3.*.*.* inhibitors
has_related_synonym: hydrolase (EC 3.*) inhibitor
has_related_synonym: hydrolase (EC 3.*) inhibitors
has_related_synonym: hydrolase inhibitor
has_related_synonym: hydrolase inhibitors
id: CHEBI:76759
in subset: 3 STAR

EC 3.1.* (ester hydrolase) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.* (ester hydrolase) inhibitors
has_related_synonym: EC 3.1.* inhibitor
has_related_synonym: EC 3.1.* inhibitors
has_related_synonym: ester hydrolase (EC 3.1.*) inhibitor
has_related_synonym: ester hydrolase (EC 3.1.*) inhibitors
has_related_synonym: ester hydrolase inhibitor
has_related_synonym: ester hydrolase inhibitors
id: CHEBI:76760
in subset: 3 STAR

EC 3.2.* (glycosylase) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: A hydrolase inhibitor that interferes with the action of any glycosylase (EC 3.2.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.* (glycosylase) inhibitors
has_related_synonym: EC 3.2.* inhibitor
has_related_synonym: EC 3.2.* inhibitors
has_related_synonym: glycosylase (EC 3.2.*) inhibitor
has_related_synonym: glycosylase (EC 3.2.*) inhibitors
has_related_synonym: glycosylase inhibitor
has_related_synonym: glycosylase inhibitors
id: CHEBI:76761
in subset: 3 STAR

EC 3.3.* (ether hydrolase) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: A hydrolase inhibitor that interferes with the action of any hydrolase acting on an ether bond (EC 3.3.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.3.* (ether hydrolase) inhibitors
has_related_synonym: EC 3.3.* (hydrolase acting on ether bond) inhibitor
has_related_synonym: EC 3.3.* (hydrolase acting on ether bond) inhibitors
has_related_synonym: EC 3.3.* inhibitor
has_related_synonym: EC 3.3.* inhibitors
has_related_synonym: ether hydrolase (EC 3.3.*) inhibitor
has_related_synonym: ether hydrolase (EC 3.3.*) inhibitors
has_related_synonym: ether hydrolase inhibitor
has_related_synonym: ether hydrolase inhibitors
id: CHEBI:76762
in subset: 3 STAR

EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor
has_related_synonym: EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors
has_related_synonym: EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor
has_related_synonym: EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors
has_related_synonym: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors
has_related_synonym: EC 3.5.* inhibitor
has_related_synonym: EC 3.5.* inhibitors
id: CHEBI:76764
in subset: 3 STAR

EC 3.7.* (hydrolases acting on C-C bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on carbon-carbon bonds (EC 3.7.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.7.* (hydrolases acting on C-C bonds) inhibitors
has_related_synonym: EC 3.7.* (hydrolases acting on carbon-carbon bonds) inhibitor
has_related_synonym: EC 3.7.* (hydrolases acting on carbon-carbon bonds) inhibitors
has_related_synonym: EC 3.7.* inhibitor
has_related_synonym: EC 3.7.* inhibitors
id: CHEBI:76766
in subset: 3 STAR

EC 3.8.* (hydrolases acting on halide bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on halide bonds (EC 3.8.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.8.* (hydrolases acting on halide bonds) inhibitors
has_related_synonym: EC 3.8.* inhibitor
has_related_synonym: EC 3.8.* inhibitors
has_related_synonym: hydrolases acting on halide bonds (EC 3.8.*) inhibitor
has_related_synonym: hydrolases acting on halide bonds (EC 3.8.*) inhibitors
has_related_synonym: inhibitor of hydrolases acting on halide bonds (EC 3.8.*)
has_related_synonym: inhibitors of hydrolases acting on halide bonds (EC 3.8.*)
id: CHEBI:76767
in subset: 3 STAR

EC 3.9.* (hydrolases acting on P-N bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on phosphorus-nitrogen bonds (EC 3.9.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.9.* (hydrolases acting on P-N bonds) inhibitors
has_related_synonym: EC 3.9.* (hydrolases acting on phosphorus-nitrogen bonds) inhibitor
has_related_synonym: EC 3.9.* (hydrolases acting on phosphorus-nitrogen bonds) inhibitors
has_related_synonym: EC 3.9.* inhibitor
has_related_synonym: EC 3.9.* inhibitors
has_related_synonym: hydrolases acting on P-N bonds (EC 3.9.*) inhibitor
has_related_synonym: hydrolases acting on P-N bonds (EC 3.9.*) inhibitors
has_related_synonym: hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*) inhibitor
has_related_synonym: hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*) inhibitors
has_related_synonym: inhibitor of hydrolases acting on P-N bonds
has_related_synonym: inhibitor of hydrolases acting on P-N bonds (EC 3.9.*)
has_related_synonym: inhibitor of hydrolases acting on phosphorus-nitrogen bonds
has_related_synonym: inhibitor of hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*)
has_related_synonym: inhibitors of hydrolases acting on P-N bonds
has_related_synonym: inhibitors of hydrolases acting on P-N bonds (EC 3.9.*)
has_related_synonym: inhibitors of hydrolases acting on phosphorus-nitrogen bonds
has_related_synonym: inhibitors of hydrolases acting on phosphorus-nitrogen bonds (EC 3.9.*)
id: CHEBI:76768
in subset: 3 STAR

EC 3.10.* (hydrolases acting on S-N bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on sulfur-nitrogen bonds (EC 3.10.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.10.* (hydrolases acting on S-N bonds) inhibitors
has_related_synonym: EC 3.10.* (hydrolases acting on sulfur-nitrogen bonds) inhibitor
has_related_synonym: EC 3.10.* (hydrolases acting on sulfur-nitrogen bonds) inhibitors
has_related_synonym: EC 3.10.* inhibitor
has_related_synonym: EC 3.10.* inhibitors
has_related_synonym: hydrolases acting on S-N bonds (EC 3.10.*) inhibitor
has_related_synonym: hydrolases acting on S-N bonds (EC 3.10.*) inhibitors
has_related_synonym: hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*) inhibitor
has_related_synonym: hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*) inhibitors
has_related_synonym: inhibitor of hydrolases acting on S-N bonds
has_related_synonym: inhibitor of hydrolases acting on S-N bonds (EC 3.10.*)
has_related_synonym: inhibitor of hydrolases acting on sulfur-nitrogen bonds
has_related_synonym: inhibitor of hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*)
has_related_synonym: inhibitors of hydrolases acting on S-N bonds
has_related_synonym: inhibitors of hydrolases acting on S-N bonds (EC 3.10.*)
has_related_synonym: inhibitors of hydrolases acting on sulfur-nitrogen bonds
has_related_synonym: inhibitors of hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*)
id: CHEBI:76769
in subset: 3 STAR

EC 3.11.* (hydrolases acting on C-P bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on carbon-phosphorus bonds (EC 3.11.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.11.* (hydrolases acting on C-P bonds) inhibitors
has_related_synonym: EC 3.11.* (hydrolases acting on carbon-phosphorus bonds) inhibitor
has_related_synonym: EC 3.11.* (hydrolases acting on carbon-phosphorus bonds) inhibitors
has_related_synonym: EC 3.11.* inhibitor
has_related_synonym: EC 3.11.* inhibitors
has_related_synonym: hydrolases acting on C-P bonds (EC 3.11.*) inhibitor
has_related_synonym: hydrolases acting on C-P bonds (EC 3.11.*) inhibitors
has_related_synonym: hydrolases acting on carbon-phosphorus bonds (EC 3.11.*) inhibitor
has_related_synonym: hydrolases acting on carbon-phosphorus bonds (EC 3.11.*) inhibitors
has_related_synonym: inhibitor of hydrolases acting on C-P bonds
has_related_synonym: inhibitor of hydrolases acting on C-P bonds (EC 3.11.*)
has_related_synonym: inhibitor of hydrolases acting on carbon-phosphorus bonds
has_related_synonym: inhibitor of hydrolases acting on carbon-phosphorus bonds (EC 3.11.*)
has_related_synonym: inhibitors of hydrolases acting on C-P bonds
has_related_synonym: inhibitors of hydrolases acting on C-P bonds (EC 3.11.*)
has_related_synonym: inhibitors of hydrolases acting on carbon-phosphorus bonds
has_related_synonym: inhibitors of hydrolases acting on carbon-phosphorus bonds (EC 3.11.*)
id: CHEBI:76770
in subset: 3 STAR

EC 3.12.* (hydrolases acting on S-S bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on sulfur-sulfur bonds (EC 3.12.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.12.* (hydrolases acting on S-S bonds) inhibitors
has_related_synonym: EC 3.12.* (hydrolases acting on sulfur-sulfur bonds) inhibitor
has_related_synonym: EC 3.12.* (hydrolases acting on sulfur-sulfur bonds) inhibitors
has_related_synonym: EC 3.12.* inhibitor
has_related_synonym: EC 3.12.* inhibitors
has_related_synonym: hydrolases acting on S-S bonds (EC 3.12.*) inhibitor
has_related_synonym: hydrolases acting on S-S bonds (EC 3.12.*) inhibitors
has_related_synonym: hydrolases acting on S-S bonds inhibitor
has_related_synonym: hydrolases acting on S-S bonds inhibitors
has_related_synonym: hydrolases acting on sulfur-sulfur bonds (EC 3.12.*) inhibitor
has_related_synonym: hydrolases acting on sulfur-sulfur bonds (EC 3.12.*) inhibitors
has_related_synonym: hydrolases acting on sulfur-sulfur bonds inhibitor
has_related_synonym: hydrolases acting on sulfur-sulfur bonds inhibitors
id: CHEBI:76771
in subset: 3 STAR

EC 3.13.* (hydrolases acting on C-S bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on carbon-sulfur bonds (EC 3.13.*.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.13.* (hydrolases acting on C-S bonds) inhibitors
has_related_synonym: EC 3.13.* (hydrolases acting on carbon-sulfur bonds) inhibitor
has_related_synonym: EC 3.13.* (hydrolases acting on carbon-sulfur bonds) inhibitors
has_related_synonym: EC 3.13.* inhibitor
has_related_synonym: EC 3.13.* inhibitors
has_related_synonym: hydrolases acting on C-S bonds (EC 3.13.*) inhibitor
has_related_synonym: hydrolases acting on C-S bonds (EC 3.13.*) inhibitors
has_related_synonym: hydrolases acting on C-S bonds inhibitor
has_related_synonym: hydrolases acting on C-S bonds inhibitors
has_related_synonym: hydrolases acting on carbon-sulfur bonds (EC 3.13.*) inhibitor
has_related_synonym: hydrolases acting on carbon-sulfur bonds (EC 3.13.*) inhibitors
has_related_synonym: hydrolases acting on carbon-sulfur bonds inhibitor
has_related_synonym: hydrolases acting on carbon-sulfur bonds inhibitors
id: CHEBI:76772
in subset: 3 STAR

EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
textual definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.1.* (carboxylic ester hydrolase) inhibitors
has_related_synonym: EC 3.1.1.* inhibitor
has_related_synonym: EC 3.1.1.* inhibitors
has_related_synonym: carboxylic ester hydrolase (EC 3.1.1.*) inhibitor
has_related_synonym: carboxylic ester hydrolase (EC 3.1.1.*) inhibitors
id: CHEBI:76773
in subset: 3 STAR

EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
textual definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors
has_related_synonym: EC 3.1.3.* inhibitor
has_related_synonym: EC 3.1.3.* inhibitors
has_related_synonym: inhibitor of phosphoric monoester hydrolase
has_related_synonym: inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)
has_related_synonym: inhibitors of phosphoric monoester hydrolase
has_related_synonym: inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)
has_related_synonym: phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor
has_related_synonym: phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors
has_related_synonym: phosphoric monoester hydrolase inhibitor
has_related_synonym: phosphoric monoester hydrolase inhibitors
id: CHEBI:76775
in subset: 3 STAR

EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.26 (prolyl oligopeptidase) inhibitors
has_related_synonym: EC 3.4.21.26 inhibitor
has_related_synonym: EC 3.4.21.26 inhibitors
has_related_synonym: endoprolylpeptidase inhibitor
has_related_synonym: endoprolylpeptidase inhibitors
has_related_synonym: post-proline cleaving enzyme inhibitor
has_related_synonym: post-proline cleaving enzyme inhibitors
has_related_synonym: post-proline endopeptidase inhibitor
has_related_synonym: post-proline endopeptidase inhibitors
has_related_synonym: proline endopeptidase inhibitor
has_related_synonym: proline endopeptidase inhibitors
has_related_synonym: proline-specific endopeptidase inhibitor
has_related_synonym: proline-specific endopeptidase inhibitors
has_related_synonym: prolyl endopeptidase inhibitor
has_related_synonym: prolyl endopeptidase inhibitors
has_related_synonym: prolyl oligopeptidase (EC 3.4.21.26) inhibitor
has_related_synonym: prolyl oligopeptidase (EC 3.4.21.26) inhibitors
has_related_synonym: prolyl oligopeptidase inhibitor
id: CHEBI:76779
in subset: 3 STAR

EC 3.4.15.* (peptidyl-dipeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a peptidyl dipeptidase (EC 3.4.15.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.15.* (peptidyl-dipeptidase) inhibitors
has_related_synonym: EC 3.4.15.* inhibitor
has_related_synonym: EC 3.4.15.* inhibitors
has_related_synonym: inhibitor of peptidyl-dipeptidases
has_related_synonym: inhibitor of peptidyl-dipeptidases (EC 3.4.15.*)
has_related_synonym: inhibitors of peptidyl-dipeptidases
has_related_synonym: inhibitors of peptidyl-dipeptidases (EC 3.4.15.*)
has_related_synonym: peptidyl-dipeptidase (EC 3.4.15.*) inhibitor
has_related_synonym: peptidyl-dipeptidase (EC 3.4.15.*) inhibitors
has_related_synonym: peptidyl-dipeptidase inhibitor
has_related_synonym: peptidyl-dipeptidase inhibitors
id: CHEBI:76782
in subset: 3 STAR

EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
textual definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitors
has_related_synonym: EC 3.1.26.* inhibitor
has_related_synonym: EC 3.1.26.* inhibitors
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitor
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitors
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters inhibitor
has_related_synonym: endoribonuclease producing 5'-phosphomonoesters inhibitors
id: CHEBI:76785
in subset: 3 STAR

EC 3.4.11.* (aminopeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes wtih the action of any aminopeptidase (EC 3.4.11.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.11.* (aminopeptidase) inhibitors
has_related_synonym: EC 3.4.11.* inhibitor
has_related_synonym: EC 3.4.11.* inhibitors
has_related_synonym: aminopeptidase (EC 3.4.11.*) inhibitor
has_related_synonym: aminopeptidase (EC 3.4.11.*) inhibitors
id: CHEBI:76787
in subset: 3 STAR

EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of any dipeptidyl- and tripeptidyl-peptidase (EC 3.4.14.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitors
has_related_synonym: EC 3.4.14.* inhibitor
has_related_synonym: EC 3.4.14.* inhibitors
has_related_synonym: EC 3.4.14.*(dipeptidyl-peptidases and tripeptidyl-peptidases) inhibitor
has_related_synonym: EC 3.4.14.*(dipeptidyl-peptidases and tripeptidyl-peptidases) inhibitors
has_related_synonym: dipeptidyl- and tripeptidyl-peptidase (EC 3.4.14.*) inhibitor
has_related_synonym: dipeptidyl- and tripeptidyl-peptidase (EC 3.4.14.*) inhibitors
has_related_synonym: dipeptidyl- and tripeptidyl-peptidase inhibitor
has_related_synonym: dipeptidyl- and tripeptidyl-peptidase inhibitors
has_related_synonym: dipeptidyl- and tripeptidyl-peptidases (EC 3.4.14.*) inhibitor
has_related_synonym: dipeptidyl- and tripeptidyl-peptidases (EC 3.4.14.*) inhibitors
has_related_synonym: dipeptidyl- and tripeptidyl-peptidases inhibitor
has_related_synonym: dipeptidyl- and tripeptidyl-peptidases inhibitors
has_related_synonym: dipeptidyl-peptidases and tripeptidyl-peptidases (EC 3.4.14.*) inhibitor
has_related_synonym: dipeptidyl-peptidases and tripeptidyl-peptidases (EC 3.4.14.*) inhibitors
id: CHEBI:76788
in subset: 3 STAR

EC 2.4.1.* (hexosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.* (glycosyltransferase) inhibitor
textual definition: An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any hexosyltransferase (EC 2.4.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.* (hexosyltransferase) inhibitors
has_related_synonym: EC 2.4.1.* inhibitor
has_related_synonym: EC 2.4.1.* inhibitors
has_related_synonym: hexosyltransferase (EC 2.4.1.*) inhibitor
has_related_synonym: hexosyltransferase (EC 2.4.1.*) inhibitors
has_related_synonym: hexosyltransferase inhibitor
has_related_synonym: hexosyltransferase inhibitors
id: CHEBI:76789
in subset: 3 STAR

EC 2.4.2.* (pentosyltransferase) inhibitor
type: Class
subclass of: EC 2.4.* (glycosyltransferase) inhibitor
textual definition: An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any pentosyltransferase (EC 2.4.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.2.* (pentosyltransferase) inhibitors
has_related_synonym: EC 2.4.2.* inhibitor
has_related_synonym: EC 2.4.2.* inhibitors
has_related_synonym: pentosyltransferase (EC 2.4.2.*) inhibitor
has_related_synonym: pentosyltransferase (EC 2.4.2.*) inhibitors
has_related_synonym: pentosyltransferase inhibitor
has_related_synonym: pentosyltransferase inhibitors
id: CHEBI:76790
in subset: 3 STAR

EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitor
type: Class
subclass of: EC 3.1.* (ester hydrolase) inhibitor
textual definition: An EC 3.1.* (ester hydrolase) inhibitor that interferes with the activity of any endoribonuclease producing other than a 5'-phosphomonoesters (EC 3.1.27.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitors
has_related_synonym: EC 3.1.27.* inhibitor
has_related_synonym: EC 3.1.27.* inhibitors
has_related_synonym: inhibitor of endoribonucleases producing other than 5'-phosphomonoesters
has_related_synonym: inhibitor of endoribonucleases producing other than 5'-phosphomonoesters (EC 3.1.27.*)
has_related_synonym: inhibitors of endoribonucleases producing other than 5'-phosphomonoesters
has_related_synonym: inhibitors of endoribonucleases producing other than 5'-phosphomonoesters (EC 3.1.27.*)
id: CHEBI:76791
in subset: 3 STAR

EC 3.4.22.36 (caspase-1) inhibitor
type: Class
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: Any EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the activity of caspase-1 (EC 3.4.22.36).
imported from: chebi.owl
has cross-reference: Wikipedia:Caspase_1
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.22.36 (caspase-1) inhibitors
has_related_synonym: EC 3.4.22.36 inhibitor
has_related_synonym: EC 3.4.22.36 inhibitors
has_related_synonym: ICE inhibitor
has_related_synonym: ICE inhibitors
has_related_synonym: caspase-1 (EC 3.4.22.36) inhibitor
has_related_synonym: caspase-1 (EC 3.4.22.36) inhibitors
has_related_synonym: caspase-1 inhibitor
has_related_synonym: caspase-1 inhibitors
has_related_synonym: interleukin 1 converting enzyme inhibitor
has_related_synonym: interleukin 1 converting enzyme inhibitors
has_related_synonym: interleukin 1beta converting enzyme inhibitor
has_related_synonym: interleukin 1beta converting enzyme inhibitors
has_related_synonym: interleukin 1beta precursor proteinase inhibitor
has_related_synonym: interleukin 1beta precursor proteinase inhibitors
has_related_synonym: interleukin 1beta-converting endopeptidase inhibitor
has_related_synonym: interleukin 1beta-converting endopeptidase inhibitors
has_related_synonym: interleukin 1beta-converting enzyme inhibitor
has_related_synonym: interleukin 1beta-converting enzyme inhibitors
has_related_synonym: interleukin-1 beta convertase precursor inhibitor
has_related_synonym: interleukin-1 beta convertase precursor inhibitors
has_related_synonym: interleukin-1beta convertase inhibitor
has_related_synonym: interleukin-1beta convertase inhibitors
has_related_synonym: interleukin-1beta converting enzyme inhibitor
has_related_synonym: interleukin-1beta converting enzyme inhibitors
has_related_synonym: interleukin-1beta precursor proteinase inhibitor
has_related_synonym: interleukin-1beta precursor proteinase inhibitors
has_related_synonym: precursor interleukin-1beta converting enzyme inhibitor
has_related_synonym: precursor interleukin-1beta converting enzyme inhibitors
has_related_synonym: pro-interleukin 1beta proteinase inhibitor
has_related_synonym: pro-interleukin 1beta proteinase inhibitors
has_related_synonym: prointerleukin 1beta protease inhibitor
has_related_synonym: prointerleukin 1beta protease inhibitors
has_related_synonym: protease A inhibitor
has_related_synonym: protease A inhibitors
has_related_synonym: protease VII inhibitor
has_related_synonym: protease VII inhibitors
id: CHEBI:76795
in subset: 3 STAR

EC 3.4.22.* (cysteine endopeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the action of any cysteine endopeptidase (EC 3.4.22.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.22.* (cysteine endopeptidase) inhibitors
has_related_synonym: EC 3.4.22.* inhibitor
has_related_synonym: EC 3.4.22.* inhibitors
has_related_synonym: cysteine endopeptidase (EC 3.4.22.*) inhibitor
has_related_synonym: cysteine endopeptidase (EC 3.4.22.*) inhibitors
has_related_synonym: cysteine endopeptidase inhibitor
has_related_synonym: cysteine endopeptidase inhibitors
id: CHEBI:76796
in subset: 3 STAR

EC 2.5.1.18 (glutathione transferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of a glutathione transferase (EC 2.5.1.18).
imported from: chebi.owl
has cross-reference: Wikipedia:Glutathione_S-transferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.1.18 (glutathione transferase) inhibitors
has_related_synonym: EC 2.5.1.18 inhibitor
has_related_synonym: EC 2.5.1.18 inhibitors
has_related_synonym: RX:glutathione R-transferase inhibitor
has_related_synonym: RX:glutathione R-transferase inhibitors
has_related_synonym: S-(hydroxyalkyl)glutathione lyase inhibitor
has_related_synonym: S-(hydroxyalkyl)glutathione lyase inhibitors
has_related_synonym: glutathione S-alkyl transferase inhibitor
has_related_synonym: glutathione S-alkyl transferase inhibitors
has_related_synonym: glutathione S-alkyltransferase inhibitor
has_related_synonym: glutathione S-alkyltransferase inhibitors
has_related_synonym: glutathione S-aralkyltransferase inhibitor
has_related_synonym: glutathione S-aralkyltransferase inhibitors
has_related_synonym: glutathione S-aryltransferase inhibitor
has_related_synonym: glutathione S-aryltransferase inhibitors
has_related_synonym: glutathione S-transferase inhibitor
has_related_synonym: glutathione S-transferase inhibitors
has_related_synonym: glutathione transferase (EC 2.5.1.18) inhibitor
has_related_synonym: glutathione transferase (EC 2.5.1.18) inhibitors
has_related_synonym: glutathione transferase inhibitor
has_related_synonym: glutathione transferase inhibitors
id: CHEBI:76797
in subset: 3 STAR

EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor
textual definition: An EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of steroid 11beta-monooxygenase (EC 1.14.15.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Steroid_11-beta-hydroxylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitors
has_related_synonym: EC 1.14.15.4 inhibitor
has_related_synonym: EC 1.14.15.4 inhibitors
has_related_synonym: cytochrome p450 XIB1 inhibitor
has_related_synonym: cytochrome p450 XIB1 inhibitors
has_related_synonym: steroid 11beta-hydroxylase inhibitor
has_related_synonym: steroid 11beta-hydroxylase inhibitors
has_related_synonym: steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor
has_related_synonym: steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitors
has_related_synonym: steroid 11beta-monooxygenase inhibitors
has_related_synonym: steroid 11beta/18-hydroxylase inhibitor
has_related_synonym: steroid 11beta/18-hydroxylase inhibitors
has_related_synonym: steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating) inhibitor
has_related_synonym: steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating) inhibitors
id: CHEBI:76798
in subset: 3 STAR

EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
type: Class
subclass of: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
textual definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors
has_related_synonym: EC 3.5.1.* inhibitor
has_related_synonym: EC 3.5.1.* inhibitors
has_related_synonym: non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor
has_related_synonym: non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors
id: CHEBI:76807
in subset: 3 STAR

EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor
type: Class
subclass of: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
textual definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitors
has_related_synonym: EC 3.5.2.* inhibitor
has_related_synonym: EC 3.5.2.* inhibitors
has_related_synonym: non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitor
has_related_synonym: non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitors
has_related_synonym: non-peptide cyclic amide C-N hydrolase inhibitor
has_related_synonym: non-peptide cyclic amide C-N hydrolase inhibitors
id: CHEBI:76808
in subset: 3 STAR

EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor
type: Class
subclass of: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
textual definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide cyclic amidine C-N hydrolase (EC 3.5.4.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitors
has_related_synonym: non-peptide cyclic amidine C-N hydrolase (EC 3.5.4.*) inhibitor
has_related_synonym: non-peptide cyclic amidine C-N hydrolase (EC 3.5.4.*) inhibitors
has_related_synonym: non-peptide cyclic amidine C-N hydrolase inhibitor
has_related_synonym: non-peptide cyclic amidine C-N hydrolase inhibitors
id: CHEBI:76809
in subset: 3 STAR

EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor
type: Class
subclass of: EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
textual definition: An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of sphingomyelin phosphodiesterase (EC 3.1.4.12).
imported from: chebi.owl
has cross-reference: Wikipedia:Sphingomyelin_phosphodiesterase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitors
has_related_synonym: EC 3.1.4.12 inhibitor
has_related_synonym: EC 3.1.4.12 inhibitors
has_related_synonym: SMase inhibitor
has_related_synonym: SMase inhibitors
has_related_synonym: acid sphingomyelinase inhibitor
has_related_synonym: acid sphingomyelinase inhibitors
has_related_synonym: neutral sphingomyelinase inhibitor
has_related_synonym: neutral sphingomyelinase inhibitors
has_related_synonym: sphingomyelin cholinephosphohydrolase inhibitor
has_related_synonym: sphingomyelin cholinephosphohydrolase inhibitors
has_related_synonym: sphingomyelin phosphodiesterase (EC 3.1.4.12) inhibitor
has_related_synonym: sphingomyelin phosphodiesterase (EC 3.1.4.12) inhibitors
has_related_synonym: sphingomyelin phosphodiesterase inhibitor
has_related_synonym: sphingomyelin phosphodiesterase inhibitors
id: CHEBI:76811
in subset: 3 STAR

EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
type: Class
subclass of: protein kinase inhibitor
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.11.* (protein-serine/threonine kinase) inhibitors
has_related_synonym: EC 2.7.11.* inhibitor
has_related_synonym: EC 2.7.11.* inhibitors
has_related_synonym: protein-serine/threonine kinase (EC 2.7.11.*) inhibitor
has_related_synonym: protein-serine/threonine kinase (EC 2.7.11.*) inhibitors
has_related_synonym: protein-serine/threonine kinase inhibitor
has_related_synonym: protein-serine/threonine kinase inhibitors
id: CHEBI:76812
in subset: 3 STAR

EC 2.7.7.* (nucleotidyltransferase) inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.7.* (nucleotidyltransferase) inhibitors
has_related_synonym: inhibitor of nucleotidyltransferases
has_related_synonym: inhibitor of nucleotidyltransferases (EC 2.7.7.*)
has_related_synonym: inhibitors of nucleotidyltransferases
has_related_synonym: inhibitors of nucleotidyltransferases (EC 2.7.7.*)
has_related_synonym: nucleotidyltransferase (EC 2.7.7.*) inhibitor
has_related_synonym: nucleotidyltransferase (EC 2.7.7.*) inhibitors
has_related_synonym: nucleotidyltransferase inhibitor
has_related_synonym: nucleotidyltransferase inhibitors
id: CHEBI:76815
in subset: 3 STAR

EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with any enzyme in the EC 2.7.8.* (transferases for other substituted phosphate groups) category.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitors
has_related_synonym: EC 2.7.8.* inhibitor
has_related_synonym: EC 2.7.8.* inhibitors
id: CHEBI:76816
in subset: 3 STAR

EC 2.7.10.* (protein-tyrosine kinase) inhibitor
type: Class
subclass of: protein kinase inhibitor
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-tyrosine kinase (EC 2.7.10.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.10.* (protein-tyrosine kinase) inhibitors
has_related_synonym: EC 2.7.10.* inhibitor
has_related_synonym: EC 2.7.10.* inhibitors
has_related_synonym: protein-tyrosine kinase (EC 2.7.10.*) inhibitor
has_related_synonym: protein-tyrosine kinase (EC 2.7.10.*) inhibitors
has_related_synonym: protein-tyrosine kinase inhibitor
has_related_synonym: protein-tyrosine kinase inhibitors
id: CHEBI:76817
in subset: 3 STAR

EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferases with a nitrogenous group as acceptor (EC 2.7.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitors
has_related_synonym: EC 2.7.3.* inhibitor
has_related_synonym: EC 2.7.3.* inhibitors
has_related_synonym: phosphotransferases with a nitrogenous group as acceptor (EC 2.7.3.*) inhibitor
has_related_synonym: phosphotransferases with a nitrogenous group as acceptor (EC 2.7.3.*) inhibitors
id: CHEBI:76818
in subset: 3 STAR

EC 3.2.1.31 (beta-glucuronidase) inhibitor
type: Class
subclass of: EC 3.2.1.* (glycosidase) inhibitor
textual definition: An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of beta-glucuronidase (EC 3.2.1.31).
imported from: chebi.owl
has cross-reference: Wikipedia:Beta-glucuronidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.31 (beta-glucuronidase) inhibitors
has_related_synonym: EC 3.2.1.31 inhibitor
has_related_synonym: EC 3.2.1.31 inhibitors
has_related_synonym: beta-D-glucuronoside glucuronosohydrolase inhibitor
has_related_synonym: beta-D-glucuronoside glucuronosohydrolase inhibitors
has_related_synonym: beta-glucuronidase (EC 3.2.1.31) inhibitor
has_related_synonym: beta-glucuronidase (EC 3.2.1.31) inhibitors
has_related_synonym: beta-glucuronidase inhibitor
has_related_synonym: beta-glucuronidase inhibitors
has_related_synonym: beta-glucuronide glucuronohydrolase inhibitor
has_related_synonym: beta-glucuronide glucuronohydrolase inhibitors
has_related_synonym: exo-beta-D-glucuronidase inhibitor
has_related_synonym: exo-beta-D-glucuronidase inhibitors
has_related_synonym: glucuronidase inhibitor
has_related_synonym: glucuronidase inhibitors
has_related_synonym: ketodase inhibitor
has_related_synonym: ketodase inhibitors
id: CHEBI:76822
in subset: 3 STAR

EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
type: Class
subclass of: EC 6.3.* (C-N bond-forming ligase) inhibitor
textual definition: An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors
has_related_synonym: EC 6.3.1.* inhibitor
has_related_synonym: EC 6.3.1.* inhibitors
has_related_synonym: acid-ammonia (or amine) ligase inhibitor
has_related_synonym: acid-ammonia (or amine) ligase inhibitors
id: CHEBI:76823
in subset: 3 STAR

EC 6.4.1.* (carboxylase) inhibitor
type: Class
subclass of: EC 6.4.* (C-C bond-forming ligase) inhibitor
textual definition: An EC 6.4.* (C-C bond-forming ligase) inhibitor that interferes with the action of a carboxylating enzyme (EC 6.4.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.4.1.* (C-C bond forming ligase) inhibitor
has_related_synonym: EC 6.4.1.* (C-C bond forming ligase) inhibitors
has_related_synonym: EC 6.4.1.* (C-C bond-forming ligase) inhibitors
has_related_synonym: EC 6.4.1.* (carboxylase) inhibitors
has_related_synonym: EC 6.4.1.* inhibitor
has_related_synonym: EC 6.4.1.* inhibitors
has_related_synonym: inhibitor of ligases forming C-C bonds
has_related_synonym: inhibitor of ligases forming C-C bonds (EC 6.4.1.*)
has_related_synonym: inhibitors of ligases forming C-C bonds
has_related_synonym: inhibitors of ligases forming C-C bonds (EC 6.4.1.*)
id: CHEBI:76824
in subset: 3 STAR

EC 6.5.1.* (DNA/RNA repair enzymes) inhibitor
type: Class
subclass of: EC 6.5.* (phosphoric ester bond-forming ligase) inhibitor
textual definition: An EC 6.5.* (phosphoric ester bond-forming ligase) inhibitor that inhibits the activity of and DNA or RNA repair enzyme (EC 6.5.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.5.1.* (DNA/RNA repair enzymes) inhibitors
has_related_synonym: EC 6.5.1.* inhibitor
has_related_synonym: EC 6.5.1.* inhibitors
id: CHEBI:76827
in subset: 3 STAR

EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitor
type: Class
subclass of: EC 5.1.* (racemase/epimerase) inhibitor
textual definition: An EC 5.1.* (racemase/epimerase) inhibitor that interferes with the function of any racemase acting on amino acids or their derivatives (EC 5.1.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitors
has_related_synonym: EC 5.1.1.* inhibitor
has_related_synonym: EC 5.1.1.* inhibitors
has_related_synonym: inhibitor of racemases acting on amino acids and derivatives
has_related_synonym: inhibitor of racemases acting on amino acids and derivatives (EC 5.1.1.*)
has_related_synonym: inhibitors of racemases acting on amino acids and derivatives
has_related_synonym: inhibitors of racemases acting on amino acids and derivatives (EC 5.1.1.*)
id: CHEBI:76828
in subset: 3 STAR

EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitor
type: Class
subclass of: EC 5.4.* (intramolecular transferase) inhibitor
textual definition: An EC 5.4.* (intramolecular transferase) inhibitor that interferes with the activity of any intramolecular transferase transferring amino groups (EC 5.4.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitors
has_related_synonym: EC 5.4.3.* inhibitor
has_related_synonym: EC 5.4.3.* inhibitors
has_related_synonym: inhibitor of intramolecular transferase transferring amino groups
has_related_synonym: inhibitor of intramolecular transferase transferring amino groups (EC 5.4.3.*)
has_related_synonym: inhibitors of intramolecular transferase transferring amino groups
has_related_synonym: inhibitors of intramolecular transferase transferring amino groups (EC 5.4.3.*)
id: CHEBI:76829
in subset: 3 STAR

EC 5.99.1.* (miscellaneous isomerase) inhibitor
type: Class
subclass of: EC 5.99.* (other isomerases) inhibitor
textual definition: An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.99.1.* (miscellaneous isomerase) inhibitors
has_related_synonym: EC 5.99.1.* inhibitor
has_related_synonym: EC 5.99.1.* inhibitors
id: CHEBI:76830
in subset: 3 STAR

EC 4.4.1.* (C-S lyase) inhibitor
type: Class
subclass of: EC 4.4.* (C-S lyase) inhibitor
textual definition: An EC 4.4.* (C-S lyase) inhibitor that interferes with the activity of any enzyme in the EC 4.4.1.* category.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C-S lyase (EC 4.4.1.*) inhibitor
has_related_synonym: C-S lyase (EC 4.4.1.*) inhibitors
has_related_synonym: EC 4.4.1.* (C-S lyase) inhibitors
has_related_synonym: EC 4.4.1.* inhibitor
has_related_synonym: EC 4.4.1.* inhibitors
id: CHEBI:76831
in subset: 3 STAR

EC 4.3.1.* (ammonia-lyase) inhibitor
type: Class
subclass of: EC 4.3.* (C-N lyase) inhibitor
textual definition: An EC 4.3.* (C-N lyase) inhibitor that interferes with the action of any ammonia-lyase (EC 4.3.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.3.1.* (ammonia-lyase) inhibitors
has_related_synonym: EC 4.3.1.* (ammonia-lyases) inhibitor
has_related_synonym: EC 4.3.1.* (ammonia-lyases) inhibitors
has_related_synonym: EC 4.3.1.* inhibitor
has_related_synonym: EC 4.3.1.* inhibitors
has_related_synonym: ammonia-lyase (EC 4.3.1.*) inhibitor
has_related_synonym: ammonia-lyase (EC 4.3.1.*) inhibitors
has_related_synonym: ammonia-lyase inhibitor
has_related_synonym: ammonia-lyase inhibitors
id: CHEBI:76832
in subset: 3 STAR

EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor
type: Class
subclass of: EC 2.* (transferase) inhibitor
textual definition: An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors
has_related_synonym: EC 2.5.* inhibitor
has_related_synonym: EC 2.5.* inhibitors
has_related_synonym: non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor
has_related_synonym: non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors
id: CHEBI:76834
in subset: 3 STAR

EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
type: Class
subclass of: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
textual definition: An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD(+) or NADP(+) as acceptor (EC 1.1.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors
has_related_synonym: EC 1.1.1.* inhibitor
has_related_synonym: EC 1.1.1.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors
id: CHEBI:76835
in subset: 3 STAR

EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
textual definition: An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.1.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitors
has_related_synonym: EC 1.1.3.* inhibitor
has_related_synonym: EC 1.1.3.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-OH group, oxygen as acceptor (EC 1.1.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group, oxygen as acceptor (EC 1.1.3.*) inhibitors
id: CHEBI:76836
in subset: 3 STAR

EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
type: Class
subclass of: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor
textual definition: An EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor that inhibits the action of any oxidoreductase incorporating 2 atoms of oxygen (EC 1.13.11.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors
has_related_synonym: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor
has_related_synonym: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors
has_related_synonym: EC 1.13.11.* inhibitor
has_related_synonym: EC 1.13.11.* inhibitors
has_related_synonym: oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor
has_related_synonym: oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors
id: CHEBI:76837
in subset: 3 STAR

EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors
has_related_synonym: EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
has_related_synonym: EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors
has_related_synonym: EC 1.14.14.* inhibitor
has_related_synonym: EC 1.14.14.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors
id: CHEBI:76838
in subset: 3 STAR

EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any enzyme in the EC 1.14.99.* (miscellaneous) category.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors
has_related_synonym: EC 1.14.99.* inhibitor
has_related_synonym: EC 1.14.99.* inhibitors
has_related_synonym: miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitor
has_related_synonym: miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitors
id: CHEBI:76840
in subset: 3 STAR

EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using NADH or NADPH as one donor (EC 1.14.13.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors
has_related_synonym: EC 1.14.13.* inhibitor
has_related_synonym: EC 1.14.13.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors
id: CHEBI:76841
in subset: 3 STAR

EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme with reduced iron-sulfur protein as one donor and incorporating one atom of oxygen (EC 1.14.15.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitors
has_related_synonym: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitor
has_related_synonym: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitors
has_related_synonym: EC 1.14.15.* inhibitor
has_related_synonym: EC 1.14.15.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitors
id: CHEBI:76843
in subset: 3 STAR

EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme using a miscellaneous compound as one donor and incorporating one atom of oxygen (EC 1.14.18.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitors
has_related_synonym: EC 1.14.18.* inhibitor
has_related_synonym: EC 1.14.18.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen (EC 1.14.18.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen (EC 1.14.18.*) inhibitors
id: CHEBI:76845
in subset: 3 STAR

EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme using reduced pteridine as one donor and incorporating one atom of oxygen (EC 1.14.16.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitors
has_related_synonym: EC 1.14.16.* inhibitor
has_related_synonym: EC 1.14.16.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen (EC 1.14.16.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen (EC 1.14.16.*) inhibitors
id: CHEBI:76847
in subset: 3 STAR

EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor
type: Class
subclass of: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
textual definition: An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the activity of any such enzyme that uses a disulfide as acceptor (EC 1.17.4.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitors
has_related_synonym: EC 1.17.4.* inhibitor
has_related_synonym: EC 1.17.4.* inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitors
id: CHEBI:76848
in subset: 3 STAR

EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
textual definition: An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the function of any such enzyme that uses oxygen as acceptor (EC 1.17.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.17.3.* inhibitor
has_related_synonym: EC 1.17.3.* inhibitors
has_related_synonym: oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitor
has_related_synonym: oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitors
id: CHEBI:76850
in subset: 3 STAR

EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
textual definition: An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.2.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.2.1.* inhibitor
has_related_synonym: EC 1.2.1.* inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitors
id: CHEBI:76852
in subset: 3 STAR

EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
textual definition: An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.2.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.2.3.* inhibitor
has_related_synonym: EC 1.2.3.* inhibitors
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors
id: CHEBI:76853
in subset: 3 STAR

EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
textual definition: An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.3.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitor
has_related_synonym: EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor
has_related_synonym: EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.3.1.* inhibitor
has_related_synonym: EC 1.3.1.* inhibitors
has_related_synonym: oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitor
has_related_synonym: oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitors
id: CHEBI:76857
in subset: 3 STAR

EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor
type: Class
subclass of: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
textual definition: An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the function of any such enzyme in the EC 1.3.98.* (with other, known, acceptors) category.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitor
has_related_synonym: EC 1.3.98.* (oxidoreductase acting on CH-CH group of donors, with other, known, acceptors) inhibitors
has_related_synonym: EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitors
has_related_synonym: EC 1.3.98.* inhibitor
has_related_synonym: EC 1.3.98.* inhibitors
has_related_synonym: oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitor
has_related_synonym: oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitors
id: CHEBI:76858
in subset: 3 STAR

EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor
type: Class
subclass of: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
textual definition: An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the function of any such enzyme in the EC 1.3.98.* (with other acceptors) category.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.99.* (oxidoreductase acting on donor CH-CH group with other acceptors) inhibitors
has_related_synonym: EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitors
has_related_synonym: EC 1.3.99.* inhibitor
has_related_synonym: EC 1.3.99.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-CH group with other acceptors (EC 1.3.99.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-CH group with other acceptors (EC 1.3.99.*) inhibitors
id: CHEBI:76859
in subset: 3 STAR

EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
textual definition: An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.3.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitor
has_related_synonym: EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitors
has_related_synonym: EC 1.3.3.* inhibitor
has_related_synonym: EC 1.3.3.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-CH group with oxygen as acceptor (EC 1.3.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-CH group with oxygen as acceptor (EC 1.3.3.*) inhibitors
id: CHEBI:76860
in subset: 3 STAR

EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
textual definition: An EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.4.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitors
has_related_synonym: EC 1.4.3.* inhibitor
has_related_synonym: EC 1.4.3.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitors
id: CHEBI:76861
in subset: 3 STAR

EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitor
type: Class
subclass of: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
textual definition: An EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor that interferes with the action of any such enzyme using a disulfide as acceptor (EC 1.4.4.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitors
has_related_synonym: EC 1.4.4.* inhibitor
has_related_synonym: EC 1.4.4.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor (EC 1.4.4.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor (EC 1.4.4.*) inhibitors
id: CHEBI:76862
in subset: 3 STAR

EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor
textual definition: An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.5.1.* inhibitor
has_related_synonym: EC 1.5.1.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors
id: CHEBI:76863
in subset: 3 STAR

EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor
type: Class
subclass of: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor
textual definition: An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using a quinone or similar as acceptor (EC 1.6.5.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors
has_related_synonym: EC 1.6.5.* inhibitor
has_related_synonym: EC 1.6.5.* inhibitors
has_related_synonym: oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor
has_related_synonym: oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors
id: CHEBI:76866
in subset: 3 STAR

EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor
textual definition: An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.6.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.6.3.* inhibitor
has_related_synonym: EC 1.6.3.* inhibitors
has_related_synonym: oxidoreductase acting on NADH or NADPH with oxygen as acceptor (EC 1.6.3.*) inhibitor
has_related_synonym: oxidoreductase acting on NADH or NADPH with oxygen as acceptor (EC 1.6.3.*) inhibitors
id: CHEBI:76867
in subset: 3 STAR

EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor
textual definition: An EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.8.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.8.1.* inhibitor
has_related_synonym: EC 1.8.1.* inhibitors
has_related_synonym: oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor
has_related_synonym: oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors
id: CHEBI:76869
in subset: 3 STAR

EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor
textual definition: An EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.9.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitors
has_related_synonym: EC 1.9.3.* inhibitor
has_related_synonym: EC 1.9.3.* inhibitors
has_related_synonym: oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitor
has_related_synonym: oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitors
id: CHEBI:76870
in subset: 3 STAR

EC 2.1.1.* (methyltransferases) inhibitor
type: Class
subclass of: EC 2.1.* (C1-transferase) inhibitor
textual definition: An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any methyltransferase (EC 2.1.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.1.1.* (methyltransferase) inhibitor
has_related_synonym: EC 2.1.1.* (methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.* (methyltransferases) inhibitors
has_related_synonym: EC 2.1.1.* inhibitor
has_related_synonym: EC 2.1.1.* inhibitors
has_related_synonym: methyltransferase (EC 2.1.1.*) inhibitor
has_related_synonym: methyltransferase (EC 2.1.1.*) inhibitors
id: CHEBI:76871
in subset: 3 STAR

EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor
type: Class
subclass of: EC 2.1.* (C1-transferase) inhibitor
textual definition: An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any hydroxymethyl-, formyl- and related transferase (EC 2.1.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitors
has_related_synonym: EC 2.1.2.* inhibitor
has_related_synonym: EC 2.1.2.* inhibitors
has_related_synonym: hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitor
has_related_synonym: hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitors
id: CHEBI:76874
in subset: 3 STAR

EC 2.2.1.* (transketolase/transaldolase) inhibitor
type: Class
subclass of: EC 2.2.* (aldehyde or ketone transferase) inhibitor
textual definition: An EC 2.2.* (aldehyde or ketone transferase) inhibitor that interferes with the action of any (transketolase or transaldolase (EC 2.2.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.2.1.* (transketolase/transaldolase) inhibitors
has_related_synonym: EC 2.2.1.* (transketolases and transaldolases) inhibitor
has_related_synonym: EC 2.2.1.* (transketolases and transaldolases) inhibitors
has_related_synonym: EC 2.2.1.* inhibitor
has_related_synonym: EC 2.2.1.* inhibitors
has_related_synonym: transketolase/transaldolase (EC 2.2.1.*) inhibitor
has_related_synonym: transketolase/transaldolase (EC 2.2.1.*) inhibitors
id: CHEBI:76876
in subset: 3 STAR

EC 2.3.2.* (aminoacyltransferase) inhibitor
type: Class
subclass of: EC 2.3.* (acyltransferase) inhibitor
textual definition: An EC 2.3.* (acyltransferase) inhibitor that interferes with the action of any aminoacyltransferase (EC 2.3.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.2.* (aminoacyltransferase) inhibitors
has_related_synonym: EC 2.3.2.* inhibitor
has_related_synonym: EC 2.3.2.* inhibitors
has_related_synonym: aminoacyltransferase (EC 2.3.2.*) inhibitor
has_related_synonym: aminoacyltransferase (EC 2.3.2.*) inhibitors
id: CHEBI:76877
in subset: 3 STAR

EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
type: Class
subclass of: EC 2.3.* (acyltransferase) inhibitor
textual definition: An EC 2.3.* (acyltransferase) inhibitor that inhibits the action of any acyltransferase transferring groups other than amino-acyl groups (EC 2.3.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors
has_related_synonym: EC 2.3.1.* inhibitor
has_related_synonym: EC 2.3.1.* inhibitors
has_related_synonym: acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitor
has_related_synonym: acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitors
id: CHEBI:76878
in subset: 3 STAR

EC 2.6.1.* (transaminase) inhibitor
type: Class
subclass of: EC 2.6.* (nitrogenous group transferase) inhibitor
textual definition: An EC 2.6.* (nitrogenous group transferase) inhibitor that inhibits the action of any transaminase (EC 2.6.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.6.1.* (transaminase) inhibitors
has_related_synonym: EC 2.6.1.* inhibitor
has_related_synonym: EC 2.6.1.* inhibitors
has_related_synonym: transaminase (EC 2.6.1.*) inhibitor
has_related_synonym: transaminase (EC 2.6.1.*) inhibitors
id: CHEBI:76879
in subset: 3 STAR

EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitors
has_related_synonym: EC 2.7.1.* inhibitor
has_related_synonym: EC 2.7.1.* inhibitors
has_related_synonym: phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitor
has_related_synonym: phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors
id: CHEBI:76881
in subset: 3 STAR

EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitor
type: Class
subclass of: EC 2.4.* (glycosyltransferase) inhibitor
textual definition: An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the activity of any glycosyltransferase in the EC 2.4.99.* (transferring other glycosyl groups) category.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitors
has_related_synonym: EC 2.4.99.* inhibitor
has_related_synonym: EC 2.4.99.* inhibitors
has_related_synonym: glycosyltransferases transferring other glycosyl groups (EC 2.4.99.*) inhibitor
has_related_synonym: glycosyltransferases transferring other glycosyl groups (EC 2.4.99.*) inhibitors
id: CHEBI:76882
in subset: 3 STAR

EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitor
type: Class
subclass of: EC 3.11.* (hydrolases acting on C-P bonds) inhibitor
textual definition: An EC 3.11.* (hydrolases acting on C-P bonds) inhibitor that interferes with the activity of any phosphonoacetaldehyde, phosphonoacetate, or phosphonopyruvate hydrolase (EC 3.11.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitors
has_related_synonym: EC 3.11.1.* inhibitor
has_related_synonym: EC 3.11.1.* inhibitors
has_related_synonym: hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate (EC 3.11.1.*) inhibitor
has_related_synonym: hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate (EC 3.11.1.*) inhibitors
id: CHEBI:76883
in subset: 3 STAR

EC 3.4.23.* (aspartic endopeptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the action of any aspartic endopeptidase (EC 3.4.23.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.23.* (aspartic endopeptidase) inhibitors
has_related_synonym: EC 3.4.23.* (aspartic endopeptidases) inhibitor
has_related_synonym: EC 3.4.23.* (aspartic endopeptidases) inhibitors
has_related_synonym: EC 3.4.23.* inhibitor
has_related_synonym: EC 3.4.23.* inhibitors
has_related_synonym: aspartic endopeptidase (EC 3.4.23.*) inhibitor
has_related_synonym: aspartic endopeptidase (EC 3.4.23.*) inhibitors
has_related_synonym: aspartic endopeptidases (EC 3.4.23.*) inhibitor
has_related_synonym: aspartic endopeptidases (EC 3.4.23.*) inhibitors
id: CHEBI:76885
in subset: 3 STAR

EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor
type: Class
subclass of: EC 3.4.11.* (aminopeptidase) inhibitor
textual definition: An EC 3.4.11.* (aminopeptidase) inhibitor that interferes with the action of cytosol alanyl aminopeptidase (EC 3.4.11.14).
imported from: chebi.owl
has cross-reference: Wikipedia:Cytosol_alanyl_aminopeptidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitors
has_related_synonym: EC 3.4.11.14 inhibitor
has_related_synonym: EC 3.4.11.14 inhibitors
has_related_synonym: alanine aminopeptidase inhibitor
has_related_synonym: alanine aminopeptidase inhibitors
has_related_synonym: aminopolypeptidase inhibitor
has_related_synonym: aminopolypeptidase inhibitors
has_related_synonym: arylamidase inhibitor
has_related_synonym: arylamidase inhibitors
has_related_synonym: cytosol alanyl aminopeptidase (EC 3.4.11.14) inhibitor
has_related_synonym: cytosol alanyl aminopeptidase (EC 3.4.11.14) inhibitors
has_related_synonym: cytosol alanyl aminopeptidase inhibitor
has_related_synonym: cytosol alanyl aminopeptidase inhibitors
has_related_synonym: cytosol aminopeptidase III inhibitor
has_related_synonym: cytosol aminopeptidase III inhibitors
has_related_synonym: human liver aminopeptidase inhibitor
has_related_synonym: human liver aminopeptidase inhibitors
has_related_synonym: puromycin-sensitive aminopeptidase inhibitor
has_related_synonym: puromycin-sensitive aminopeptidase inhibitors
has_related_synonym: soluble alanyl aminopeptidase inhibitor
has_related_synonym: soluble alanyl aminopeptidase inhibitors
has_related_synonym: thiol-activated aminopeptidase inhibitor
has_related_synonym: thiol-activated aminopeptidase inhibitors
id: CHEBI:76891
in subset: 3 STAR

EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor
type: Class
subclass of: EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor
textual definition: An EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor that interferes with the action of dipeptidyl-peptidase II (EC 3.4.14.2).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: DAP II inhibitor
has_related_synonym: DAP II inhibitors
has_related_synonym: EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitors
has_related_synonym: EC 3.4.14.2 inhibitor
has_related_synonym: EC 3.4.14.2 inhibitors
has_related_synonym: carboxytripeptidase inhibitor
has_related_synonym: carboxytripeptidase inhibitors
has_related_synonym: dipeptidyl aminopeptidase II inhibitor
has_related_synonym: dipeptidyl aminopeptidase II inhibitors
has_related_synonym: dipeptidyl arylamidase II inhibitor
has_related_synonym: dipeptidyl arylamidase II inhibitors
has_related_synonym: dipeptidyl peptidase II inhibitor
has_related_synonym: dipeptidyl peptidase II inhibitors
has_related_synonym: dipeptidyl(amino)peptidase II inhibitor
has_related_synonym: dipeptidyl(amino)peptidase II inhibitors
has_related_synonym: dipeptidyl-peptidase II (EC 3.4.14.2) inhibitor
has_related_synonym: dipeptidyl-peptidase II (EC 3.4.14.2) inhibitors
has_related_synonym: dipeptidyl-peptidase II inhibitor
has_related_synonym: dipeptidyl-peptidase II inhibitors
has_related_synonym: dipeptidylarylamidase inhibitor
has_related_synonym: dipeptidylarylamidase inhibitors
id: CHEBI:76893
in subset: 3 STAR

EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
type: Class
subclass of: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
textual definition: An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme that catalyses transmembrane movement of substances (EC 3.6.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors
has_related_synonym: EC 3.6.3.* inhibitor
has_related_synonym: EC 3.6.3.* inhibitors
has_related_synonym: acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor
has_related_synonym: acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors
id: CHEBI:76895
in subset: 3 STAR

EC 1.14.14.1 (unspecific monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
textual definition: An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of an unspecified monooxygenase (EC 1.14.14.1).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.14.1 (unspecific monooxygenase) inhibitors
has_related_synonym: EC 1.14.14.1 inhibitor
has_related_synonym: EC 1.14.14.1 inhibitors
has_related_synonym: aryl hydrocarbon hydroxylase inhibitor
has_related_synonym: aryl hydrocarbon hydroxylase inhibitors
has_related_synonym: aryl-4-monooxygenase inhibitor
has_related_synonym: aryl-4-monooxygenase inhibitors
has_related_synonym: flavoprotein monooxygenase inhibitor
has_related_synonym: flavoprotein monooxygenase inhibitors
has_related_synonym: flavoprotein-linked monooxygenase inhibitor
has_related_synonym: flavoprotein-linked monooxygenase inhibitors
has_related_synonym: microsomal P-450 inhibitor
has_related_synonym: microsomal P-450 inhibitors
has_related_synonym: microsomal monooxygenase inhibitor
has_related_synonym: microsomal monooxygenase inhibitors
has_related_synonym: substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor
has_related_synonym: substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors
has_related_synonym: unspecific monooxygenase (EC 1.14.14.1) inhibitor
has_related_synonym: unspecific monooxygenase (EC 1.14.14.1) inhibitors
has_related_synonym: unspecific monooxygenase inhibitor
has_related_synonym: unspecific monooxygenase inhibitors
has_related_synonym: xenobiotic monooxygenase inhibitor
has_related_synonym: xenobiotic monooxygenase inhibitors
id: CHEBI:76898
in subset: 3 STAR

EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the function of any such enzyme using 2-oxoglutarate as one donor and incorporating one atom each of oxygen into both donors (EC 1.14.11.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitors
has_related_synonym: EC 1.14.11.* (oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors) inhibitor
has_related_synonym: EC 1.14.11.* (oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors) inhibitors
has_related_synonym: EC 1.14.11.* inhibitor
has_related_synonym: EC 1.14.11.* inhibitors
has_related_synonym: oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors (EC 1.14.11.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors (EC 1.14.11.*) inhibitors
has_related_synonym: oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (EC 1.14.11.*) inhibitor
has_related_synonym: oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (EC 1.14.11.*) inhibitors
id: CHEBI:76902
in subset: 3 STAR

EC 4.1.1.* (carboxy-lyase) inhibitor
type: Class
subclass of: EC 4.1.* (C-C lyase) inhibitor
textual definition: An EC 4.1.* (C-C lyase) inhibitor that interferes with the action of any carboxy-lyase (EC 4.1.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.1.1.* (carboxy-lyase) inhibitors
has_related_synonym: EC 4.1.1.* inhibitor
has_related_synonym: EC 4.1.1.* inhibitors
has_related_synonym: carboxy-lyase (EC 4.1.1.*) inhibitor
has_related_synonym: carboxy-lyase (EC 4.1.1.*) inhibitors
has_related_synonym: carboxy-lyases (EC 4.1.1.*) inhibitor
has_related_synonym: carboxy-lyases (EC 4.1.1.*) inhibitors
id: CHEBI:76906
in subset: 3 STAR

EC 4.2.1.* (hydro-lyases) inhibitor
type: Class
subclass of: EC 4.2.* (C-O lyase) inhibitor
textual definition: An EC 4.2.* (C-O lyase) inhibitor that interferes with the action of any hydro-lyase (EC 4.2.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.2.1.* (hydro-lyase) inhibitor
has_related_synonym: EC 4.2.1.* (hydro-lyase) inhibitors
has_related_synonym: EC 4.2.1.* (hydro-lyases) inhibitors
has_related_synonym: EC 4.2.1.* inhibitor
has_related_synonym: EC 4.2.1.* inhibitors
has_related_synonym: hydro-lyase (EC 4.2.1.*) inhibitor
has_related_synonym: hydro-lyase (EC 4.2.1.*) inhibitors
id: CHEBI:76907
in subset: 3 STAR

hyperglycemic agent
type: Class
subclass of: drug
textual definition: A drug which increases the blood glucose level.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: diabetes inducer
has_related_synonym: hyperglycemic agents
id: CHEBI:76916
in subset: 3 STAR

EC 1.1.3.9 (galactose oxidase) inhibitor
type: Class
subclass of: EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor
textual definition: An EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor that interferes with the action of galactose oxidase (EC 1.1.3.9).
imported from: chebi.owl
has cross-reference: Wikipedia:Galactose_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: D-galactose oxidase inhibitor
has_related_synonym: D-galactose oxidase inhibitors
has_related_synonym: D-galactose:oxygen 6-oxidoreductase inhibitor
has_related_synonym: D-galactose:oxygen 6-oxidoreductase inhibitors
has_related_synonym: EC 1.1.3.9 (galactose oxidase) inhibitors
has_related_synonym: EC 1.1.3.9 inhibitor
has_related_synonym: EC 1.1.3.9 inhibitors
has_related_synonym: beta-galactose oxidase inhibitor
has_related_synonym: beta-galactose oxidase inhibitors
has_related_synonym: galactose oxidase inhibitor
has_related_synonym: galactose oxidase inhibitors
id: CHEBI:76920
in subset: 3 STAR

plant metabolite
type: Class
subclass of: eukaryotic metabolite
textual definition: Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
imported from: chebi.owl
has_alternative_id: CHEBI:75766
has_alternative_id: CHEBI:76925
has_obo_namespace: chebi_ontology
has_related_synonym: plant metabolites
has_related_synonym: plant secondary metabolites
id: CHEBI:76924
in subset: 3 STAR

EC 3.4.13.19 (membrane dipeptidase) inhibitor
type: Class
subclass of: EC 3.4.13.* (dipeptidase) inhibitor
textual definition: An EC 3.4.13.* (dipeptidase) inhibitor that interferes with the action of membrane dipeptidase (EC 3.4.13.19).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: DPH I inhibitors
has_related_synonym: EC 3.4.13.19 (membrane dipeptidase) inhibitors
has_related_synonym: EC 3.4.13.19 inhibitor
has_related_synonym: EC 3.4.13.19 inhibitors
has_related_synonym: MDP inhibitors
has_related_synonym: aminodipeptidase inhibitors
has_related_synonym: dehydropeptidase I (DPH I) inhibitors
has_related_synonym: dehydropeptidase I inhibitors
has_related_synonym: dipeptidase inhibitors
has_related_synonym: dipeptide hydrolase inhibitors
has_related_synonym: dipeptidyl hydrolase inhibitors
has_related_synonym: glycosyl-phosphatidylinositol-anchored renal dipeptidase inhibitors
has_related_synonym: membrane dipeptidase (EC 3.4.13.19) inhibitor
has_related_synonym: membrane dipeptidase (EC 3.4.13.19) inhibitors
has_related_synonym: membrane dipeptidase inhibitor
has_related_synonym: membrane dipeptidase inhibitors
has_related_synonym: microsomal dipeptidase inhibitors
has_related_synonym: nonspecific dipeptidase inhibitors
has_related_synonym: renal dipeptidase inhibitors
id: CHEBI:76926
in subset: 3 STAR

pathway inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: An enzyme inhibitor that interferes with one or more steps in a metabolic pathway.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: metabolic pathway inhibitor
has_related_synonym: metabolic pathway inhibitors
has_related_synonym: pathway inhibitors
id: CHEBI:76932
in subset: 3 STAR

EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor
type: Class
subclass of: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
textual definition: An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme acting on ATP and involved in cellular and subcellular movement (EC 3.6.4.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.6.4.* (hydrolase acting on ATP; involved in cellular and subcellular movement) inhibitor
has_related_synonym: EC 3.6.4.* (hydrolase acting on ATP; involved in cellular and subcellular movement) inhibitors
has_related_synonym: EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitors
has_related_synonym: EC 3.6.4.* inhibitor
has_related_synonym: EC 3.6.4.* inhibitors
has_related_synonym: hydrolases acting on ATP; involved in cellular and subcellular movement (EC 3.6.4.*) inhibitor
has_related_synonym: hydrolases acting on ATP; involved in cellular and subcellular movement (EC 3.6.4.*) inhibitors
id: CHEBI:76938
in subset: 3 STAR

EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor
type: Class
subclass of: EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor
textual definition: An EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor that interferes with the action of a non-chaperonin molecular chaperone ATPase (EC 3.6.4.10).
imported from: chebi.owl
has cross-reference: Wikipedia:Non-chaperonin_molecular_chaperone_ATPase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP phosphohydrolase (polypeptide-polymerising) inhibitor
has_related_synonym: ATP phosphohydrolase (polypeptide-polymerising) inhibitors
has_related_synonym: ATP phosphohydrolase (polypeptide-polymerizing) inhibitor
has_related_synonym: ATP phosphohydrolase (polypeptide-polymerizing) inhibitors
has_related_synonym: EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitors
has_related_synonym: EC 3.6.4.10 inhibitor
has_related_synonym: EC 3.6.4.10 inhibitors
has_related_synonym: molecular chaperone Hsc70 ATPase inhibitor
has_related_synonym: molecular chaperone Hsc70 ATPase inhibitors
has_related_synonym: non-chaperonin molecular chaperone ATPase (EC 3.6.4.10) inhibitor
has_related_synonym: non-chaperonin molecular chaperone ATPase (EC 3.6.4.10) inhibitors
id: CHEBI:76939
in subset: 3 STAR

EC 3.4.21.4 (trypsin) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of trypsin (EC 3.4.21.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Trypsin_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.4 (trypsin) inhibitors
has_related_synonym: EC 3.4.21.4 inhibitor
has_related_synonym: EC 3.4.21.4 inhibitors
has_related_synonym: alpha-trypsin inhibitor
has_related_synonym: alpha-trypsin inhibitors
has_related_synonym: beta-trypsin inhibitor
has_related_synonym: beta-trypsin inhibitors
has_related_synonym: cocoonase inhibitor
has_related_synonym: cocoonase inhibitors
has_related_synonym: parenzyme inhibitor
has_related_synonym: parenzyme inhibitors
has_related_synonym: parenzymol inhibitor
has_related_synonym: parenzymol inhibitors
has_related_synonym: pseudotrypsin inhibitor
has_related_synonym: pseudotrypsin inhibitors
has_related_synonym: sperm receptor hydrolase inhibitor
has_related_synonym: sperm receptor hydrolase inhibitors
has_related_synonym: tripcellim inhibitor
has_related_synonym: tripcellim inhibitors
has_related_synonym: trypsin (EC 3.4.21.4) inhibitor
has_related_synonym: trypsin (EC 3.4.21.4) inhibitors
has_related_synonym: trypsin inhibitor
has_related_synonym: trypsin inhibitors
has_related_synonym: tryptar inhibitor
has_related_synonym: tryptar inhibitors
has_related_synonym: tryptase inhibitor
has_related_synonym: tryptase inhibitors
has_related_synonym: trypure inhibitor
has_related_synonym: trypure inhibitors
id: CHEBI:76940
in subset: 3 STAR

fungal metabolite
type: Class
subclass of: eukaryotic metabolite
textual definition: Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
imported from: chebi.owl
has_alternative_id: CHEBI:75765
has_alternative_id: CHEBI:76947
has_obo_namespace: chebi_ontology
has_related_synonym: fungal metabolites
id: CHEBI:76946
in subset: 3 STAR

Aspergillus metabolite
type: Class
subclass of: fungal metabolite
textual definition: Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus.
imported from: chebi.owl
has_alternative_id: CHEBI:75864
has_alternative_id: CHEBI:76958
has_obo_namespace: chebi_ontology
has_related_synonym: Aspergillus metabolites
id: CHEBI:76956
in subset: 3 STAR

Chaetomium metabolite
type: Class
subclass of: fungal metabolite
textual definition: Any fungal metabolite produced during a metabolic reaction in the mould, Chaetomium.
imported from: chebi.owl
has_alternative_id: CHEBI:75916
has_alternative_id: CHEBI:76961
has_obo_namespace: chebi_ontology
has_related_synonym: Chaetomium metabolites
id: CHEBI:76960
in subset: 3 STAR

Penicillium metabolite
type: Class
subclass of: fungal metabolite
textual definition: Any fungal metabolite produced during a metabolic reaction in Penicillium.
imported from: chebi.owl
has_alternative_id: CHEBI:76205
has_alternative_id: CHEBI:76963
has_obo_namespace: chebi_ontology
has_related_synonym: Penicillium metabolites
id: CHEBI:76964
in subset: 3 STAR

human xenobiotic metabolite
type: Class
subclass of: xenobiotic metabolite
subclass of: human metabolite
textual definition: Any human metabolite produced by metabolism of a xenobiotic compound in humans.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: human xenobiotic metabolites
id: CHEBI:76967
in subset: 3 STAR

fungal xenobiotic metabolite
type: Class
subclass of: xenobiotic metabolite
subclass of: fungal metabolite
textual definition: Any fungal metabolite produced by metabolism of a xenobiotic compound in fungi.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fungal xenobiotic metabolites
id: CHEBI:76968
in subset: 3 STAR

bacterial metabolite
type: Class
subclass of: prokaryotic metabolite
textual definition: Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
imported from: chebi.owl
has_alternative_id: CHEBI:75760
has_alternative_id: CHEBI:76970
has_obo_namespace: chebi_ontology
id: CHEBI:76969
in subset: 3 STAR

Escherichia coli metabolite
type: Class
subclass of: bacterial metabolite
textual definition: Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: E.coli metabolite
has_related_synonym: E.coli metabolites
has_related_synonym: Escherichia coli metabolites
id: CHEBI:76971
in subset: 3 STAR

Streptococcus pneumoniae metabolite
type: Class
subclass of: bacterial metabolite
textual definition: Any bacterial metabolite produced during a metabolic reaction in Streptococcus pneumoniae.
imported from: chebi.owl
has_alternative_id: CHEBI:75789
has_alternative_id: CHEBI:76974
has_obo_namespace: chebi_ontology
has_related_synonym: S. pneumoniae metabolite
has_related_synonym: S. pneumoniae metabolites
has_related_synonym: S. pneumoniae secondary metabolite
has_related_synonym: S. pneumoniae secondary metabolites
has_related_synonym: Streptococcus pneumoniae metabolites
has_related_synonym: Streptococcus pneumoniae secondary metabolites
id: CHEBI:76973
in subset: 3 STAR

bacterial xenobiotic metabolite
type: Class
subclass of: xenobiotic metabolite
subclass of: bacterial metabolite
textual definition: Any bacterial metabolite produced by metabolism of a xenobiotic compound in bacteria.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bacterial xenobiotic metabolites
id: CHEBI:76976
in subset: 3 STAR

corticotropin-releasing factor receptor antagonist
type: Class
subclass of: hormone antagonist
textual definition: A hormone antagonist that blocks corticotropin-releasing factor receptors
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CRF antagonist
has_related_synonym: CRF antagonists
has_related_synonym: corticotropin-releasing factor receptor antagonists
id: CHEBI:76977
in subset: 3 STAR

xenoestrogen
type: Class
subclass of: endocrine disruptor
subclass of: estrogen
textual definition: A synthetic or semi-synthetic compound that has oestrogenic activity.
imported from: chebi.owl
has cross-reference: Wikipedia:Xenoestrogen
has_obo_namespace: chebi_ontology
has_related_synonym: xenoestrogens
id: CHEBI:76988
in subset: 3 STAR

phytoestrogen
type: Class
subclass of: estrogen
textual definition: Any compound produced by a plant that happens to have estrogenic activity.
imported from: chebi.owl
has cross-reference: Wikipedia:Phytoestrogen
has_obo_namespace: chebi_ontology
has_related_synonym: phytoestrogens
id: CHEBI:76989
in subset: 3 STAR

mycoestrogen
type: Class
subclass of: estrogen
textual definition: Any compound produced by a fungus that happens to have estrogenic activity.
imported from: chebi.owl
has cross-reference: PMID:17291736
has cross-reference: PMID:21392782
has cross-reference: Wikipedia:Mycoestrogen
has_obo_namespace: chebi_ontology
has_related_synonym: mycoestrogens
id: CHEBI:76990
in subset: 3 STAR

aryl hydrocarbon receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and activates aryl hydrocarbon receptors (AhRs).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: AhR antagonist
has_related_synonym: AhR antagonists
has_related_synonym: AhR receptor antagonist
has_related_synonym: AhR receptor antagonists
has_related_synonym: aryl hydrocarbon receptor antagonists
id: CHEBI:76998
in subset: 3 STAR

EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor
type: Class
subclass of: EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor
textual definition: An EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor that interferes with the action of any such enzyme in the EC 1.10.99.* category.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitors
has_related_synonym: EC 1.10.99.* inhibitor
has_related_synonym: EC 1.10.99.* inhibitors
has_related_synonym: oxidoreductases acting on diphenols and related substances as donors, other acceptors (EC 1.10.99.*) inhibitor
has_related_synonym: oxidoreductases acting on diphenols and related substances as donors, other acceptors (EC 1.10.99.*) inhibitors
id: CHEBI:77019
in subset: 3 STAR

EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor
type: Class
subclass of: EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor
textual definition: An EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor that interferes with the action of ribosyldihydronicotinamide dehydrogenase (quinone), EC 1.10.99.2.
imported from: chebi.owl
has cross-reference: Wikipedia:Ribosyldihydronicotinamide_dehydrogenase_(quinone)
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase inhibitor
has_related_synonym: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase inhibitors
has_related_synonym: EC 1.10.99.2 (ribosyldihydronicotinamide dehydrogenase (quinone)) inhibitor
has_related_synonym: EC 1.10.99.2 (ribosyldihydronicotinamide dehydrogenase (quinone)) inhibitors
has_related_synonym: EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitors
has_related_synonym: EC 1.10.99.2 inhibitor
has_related_synonym: EC 1.10.99.2 inhibitors
has_related_synonym: N-ribosyldihydronicotinamide dehydrogenase (quinone) inhibitor
has_related_synonym: N-ribosyldihydronicotinamide dehydrogenase (quinone) inhibitors
has_related_synonym: NAD(P)H:quinone oxidoreductase-2 inhibitor
has_related_synonym: NAD(P)H:quinone oxidoreductase-2 inhibitors
has_related_synonym: NAD(P)H:quinone oxidoreductase2 inhibitor
has_related_synonym: NAD(P)H:quinone oxidoreductase2 inhibitors
has_related_synonym: NQO2 inhibitor
has_related_synonym: NQO2 inhibitors
has_related_synonym: NRH:quinone oxidoreductase 2 inhibitor
has_related_synonym: NRH:quinone oxidoreductase 2 inhibitors
has_related_synonym: QR2 inhibitor
has_related_synonym: QR2 inhibitors
has_related_synonym: quinone reductase 2 inhibitor
has_related_synonym: quinone reductase 2 inhibitors
has_related_synonym: ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) inhibitor
has_related_synonym: ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) inhibitors
id: CHEBI:77020
in subset: 3 STAR

EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor
type: Class
subclass of: EC 2.3.* (acyltransferase) inhibitor
textual definition: An EC 2.3.* (acyltransferase) inhibitor that interferes with the action of an acyltransferase which converts the acyl group to an alkyl group on transfer (EC 2.3.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitors
has_related_synonym: EC 2.3.3.* inhibitor
has_related_synonym: EC 2.3.3.* inhibitors
has_related_synonym: acyltransferase converting acyl to alkyl group on transfer (EC 2.3.3.*) inhibitor
has_related_synonym: acyltransferase converting acyl to alkyl group on transfer (EC 2.3.3.*) inhibitors
id: CHEBI:77022
in subset: 3 STAR

EC 2.3.3.1 [citrate (Si)-synthase] inhibitor
type: Class
subclass of: EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor
textual definition: An EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor that interferes with the action of citrate (Si)-synthase, EC 2.3.3.1.
imported from: chebi.owl
has cross-reference: Wikipedia:Citrate_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: (R)-citrate synthase inhibitor
has_related_synonym: (R)-citrate synthase inhibitors
has_related_synonym: EC 2.3.3.1 (citrate (Si)-synthase) inhibitor
has_related_synonym: EC 2.3.3.1 (citrate (Si)-synthase) inhibitors
has_related_synonym: EC 2.3.3.1 [citrate (Si)-synthase] inhibitors
has_related_synonym: EC 2.3.3.1 inhibitor
has_related_synonym: EC 2.3.3.1 inhibitors
has_related_synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] inhibitor
has_related_synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] inhibitors
has_related_synonym: citrate (Si)-synthase (EC 2.3.3.1) inhibitor
has_related_synonym: citrate (Si)-synthase (EC 2.3.3.1) inhibitors
has_related_synonym: citrate condensing enzyme inhibitor
has_related_synonym: citrate condensing enzyme inhibitors
has_related_synonym: citrate oxaloacetate-lyase [(pro-3S)-CH2COO->acetyl-CoA] inhibitor
has_related_synonym: citrate oxaloacetate-lyase [(pro-3S)-CH2COO->acetyl-CoA] inhibitors
has_related_synonym: citrate oxaloacetate-lyase, CoA-acetylating inhibitor
has_related_synonym: citrate oxaloacetate-lyase, CoA-acetylating inhibitors
has_related_synonym: citrate synthase inhibitor
has_related_synonym: citrate synthase inhibitors
has_related_synonym: citrate synthetase inhibitor
has_related_synonym: citrate synthetase inhibitors
has_related_synonym: citric synthase inhibitor
has_related_synonym: citric synthase inhibitors
has_related_synonym: citric-condensing enzyme inhibitor
has_related_synonym: citric-condensing enzyme inhibitors
has_related_synonym: citrogenase inhibitor
has_related_synonym: citrogenase inhibitors
has_related_synonym: condensing enzyme inhibitor
has_related_synonym: condensing enzyme inhibitors
has_related_synonym: oxalacetic transacetase inhibitor
has_related_synonym: oxalacetic transacetase inhibitors
has_related_synonym: oxaloacetate transacetase inhibitor
has_related_synonym: oxaloacetate transacetase inhibitors
id: CHEBI:77023
in subset: 3 STAR

EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor
type: Class
subclass of: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
textual definition: An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of 4-nitrophenylphosphatase (EC 3.1.3.41).
imported from: chebi.owl
has cross-reference: Wikipedia:4-nitrophenylphosphatase
has_obo_namespace: chebi_ontology
has_related_synonym: 4-nitrophenylphosphatase (EC 3.1.3.41) inhibitor
has_related_synonym: 4-nitrophenylphosphatase (EC 3.1.3.41) inhibitors
has_related_synonym: 4-nitrophenylphosphate phosphohydrolase inhibitor
has_related_synonym: 4-nitrophenylphosphate phosphohydrolase inhibitors
has_related_synonym: EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitors
has_related_synonym: EC 3.1.3.41 inhibitor
has_related_synonym: EC 3.1.3.41 inhibitors
has_related_synonym: Ecto-p-nitrophenyl phosphatase inhibitor
has_related_synonym: Ecto-p-nitrophenyl phosphatase inhibitors
has_related_synonym: K-pNPPase inhibitor
has_related_synonym: K-pNPPase inhibitors
has_related_synonym: NPPase inhibitor
has_related_synonym: NPPase inhibitors
has_related_synonym: PNPPase inhibitor
has_related_synonym: PNPPase inhibitors
has_related_synonym: nitrophenyl phosphatase inhibitor
has_related_synonym: nitrophenyl phosphatase inhibitors
has_related_synonym: p-nitrophenylphosphatase inhibitor
has_related_synonym: p-nitrophenylphosphatase inhibitors
has_related_synonym: p-nitrophenylphosphate phosphohydrolase inhibitor
has_related_synonym: p-nitrophenylphosphate phosphohydrolase inhibitors
has_related_synonym: para-nitrophenyl phosphatase inhibitor
has_related_synonym: para-nitrophenyl phosphatase inhibitors
has_related_synonym: xK-pNPPase inhibitors
id: CHEBI:77024
in subset: 3 STAR

mucolytic
type: Class
subclass of: drug
textual definition: A compound that alters the structure of mucus so as to decrease its viscosity and thereby facilitate its removal by ciliary action and expectoration. Compare with antitussives, which suppress the cough reflex, and expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing.
imported from: chebi.owl
has cross-reference: PMID:17419975
has cross-reference: PMID:17594730
has cross-reference: PMID:20031934
has cross-reference: PMID:2117172
has cross-reference: PMID:22895919
has_obo_namespace: chebi_ontology
has_related_synonym: mucolytics
id: CHEBI:77034
in subset: 3 STAR

expectorant
type: Class
subclass of: drug
textual definition: Compounds that are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing. Compare with mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration, and antitussives, which suppress the cough reflex.
imported from: chebi.owl
has cross-reference: PMID:17594730
has_obo_namespace: chebi_ontology
has_related_synonym: expectorants
id: CHEBI:77035
in subset: 3 STAR

EC 1.4.7.* (oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor) inhibitor
type: Class
subclass of: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
textual definition: An EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor that interferes with the action of any such enzyme using a iron-sulfur protein as acceptor (EC 1.4.7.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.7.* (oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor) inhibitors
has_related_synonym: EC 1.4.7.* inhibitor
has_related_synonym: EC 1.4.7.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor
has_related_synonym: inhibitors of oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor
has_related_synonym: oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor (EC 1.4.7.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor (EC 1.4.7.*) inhibitors
id: CHEBI:77088
in subset: 3 STAR

EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49).
imported from: chebi.owl
has cross-reference: Wikipedia:O-acetylhomoserine_aminocarboxypropyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitors
has_related_synonym: EC 2.5.1.49 inhibitor
has_related_synonym: EC 2.5.1.49 inhibitors
has_related_synonym: O-acetyl-L-homoserine acetate-lyase (adding methanethiol) inhibitor
has_related_synonym: O-acetyl-L-homoserine acetate-lyase (adding methanethiol) inhibitors
has_related_synonym: O-acetyl-L-homoserine sulfhydrolase inhibitor
has_related_synonym: O-acetyl-L-homoserine sulfhydrolase inhibitors
has_related_synonym: O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase inhibitor
has_related_synonym: O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase inhibitors
has_related_synonym: O-acetylhomoserine (thiol)-lyase inhibitor
has_related_synonym: O-acetylhomoserine (thiol)-lyase inhibitors
has_related_synonym: O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) inhibitor
has_related_synonym: O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) inhibitors
has_related_synonym: O-acetylhomoserine aminocarboxypropyltransferase inhibitor
has_related_synonym: O-acetylhomoserine aminocarboxypropyltransferase inhibitors
has_related_synonym: O-acetylhomoserine sulfhydrolase inhibitor
has_related_synonym: O-acetylhomoserine sulfhydrolase inhibitors
has_related_synonym: methionine synthase inhibitor
has_related_synonym: methionine synthase inhibitors
id: CHEBI:77089
in subset: 3 STAR

EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
type: Class
subclass of: EC 4.3.1.* (ammonia-lyase) inhibitor
textual definition: An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of serine-sulfate ammonia-lyase (EC 4.3.1.10).
imported from: chebi.owl
has cross-reference: Wikipedia:Serine-sulfate_ammonia-lyase
has_obo_namespace: chebi_ontology
has_related_synonym: (L-SOS)lyase inhibitor
has_related_synonym: (L-SOS)lyase inhibitors
has_related_synonym: EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitors
has_related_synonym: EC 4.3.1.10 inhibitor
has_related_synonym: EC 4.3.1.10 inhibitors
has_related_synonym: L-serine-O-sulfate ammonia-lyase (pyruvate-forming) inhibitor
has_related_synonym: L-serine-O-sulfate ammonia-lyase (pyruvate-forming) inhibitors
has_related_synonym: serine-sulfate ammonia-lyase (EC 4.3.1.10) inhibitor
has_related_synonym: serine-sulfate ammonia-lyase (EC 4.3.1.10) inhibitors
has_related_synonym: serine-sulfate ammonia-lyase inhibitor
has_related_synonym: serine-sulfate ammonia-lyase inhibitors
id: CHEBI:77090
in subset: 3 STAR

EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor
type: Class
subclass of: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
textual definition: An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using a quinone or related compound as acceptor (EC 1.3.5.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitors
has_related_synonym: EC 1.3.5.* inhibitor
has_related_synonym: EC 1.3.5.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor
has_related_synonym: inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor
has_related_synonym: inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)
has_related_synonym: oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitor
has_related_synonym: oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors
id: CHEBI:77102
in subset: 3 STAR

EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor
type: Class
subclass of: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor
textual definition: An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2.
imported from: chebi.owl
has cross-reference: Wikipedia:Dihydroorotate_dehydrogenase_(quinone)
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-dihydroorotate:(acceptor) oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:(acceptor) oxidoreductase inhibitors
has_related_synonym: (S)-dihydroorotate:acceptor oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:acceptor oxidoreductase inhibitors
has_related_synonym: (S)-dihydroorotate:quinone oxidoreductase inhibitor
has_related_synonym: (S)-dihydroorotate:quinone oxidoreductase inhibitors
has_related_synonym: DHOD inhibitor
has_related_synonym: DHOD inhibitors
has_related_synonym: DHODH inhibitor
has_related_synonym: DHODH inhibitors
has_related_synonym: DHOdehase inhibitor
has_related_synonym: DHOdehase inhibitors
has_related_synonym: EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitor
has_related_synonym: EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitors
has_related_synonym: EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitors
has_related_synonym: EC 1.3.5.2 inhibitor
has_related_synonym: EC 1.3.5.2 inhibitors
has_related_synonym: dihydroorotate:ubiquinone oxidoreductase inhibitor
has_related_synonym: dihydroorotate:ubiquinone oxidoreductase inhibitors
id: CHEBI:77103
in subset: 3 STAR

EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor
type: Class
subclass of: EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor
textual definition: An EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor that interferes with the action of any such enzyme using a cytochrome as acceptor (EC 1.10.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitors
has_related_synonym: EC 1.10.2.* inhibitor
has_related_synonym: EC 1.10.2.* inhibitors
has_related_synonym: inhibitor of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*)
has_related_synonym: inhibitors of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*)
has_related_synonym: oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitor
has_related_synonym: oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) inhibitors
id: CHEBI:77105
in subset: 3 STAR

EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor
type: Class
subclass of: EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor
textual definition: An EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor that interferes with the action of quinol--cytochrome-c reductase (EC 1.10.2.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitors
has_related_synonym: EC 1.10.2.2 inhibitor
has_related_synonym: EC 1.10.2.2 inhibitors
has_related_synonym: inhibitor of quinol--cytochrome-c reductase (EC 1.10.2.2)
has_related_synonym: inhibitors of quinol--cytochrome-c reductase (EC 1.10.2.2)
has_related_synonym: quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitor
has_related_synonym: quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitors
id: CHEBI:77106
in subset: 3 STAR

EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of 15-hydroxyprostaglandin dehydrogenase (NAD(+)) (EC 1.1.1.141).
imported from: chebi.owl
has cross-reference: PMID:21072165
has cross-reference: Wikipedia:15-hydroxyprostaglandin_dehydrogenase_(NAD%2B)
has_obo_namespace: chebi_ontology
has_related_synonym: (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitor
has_related_synonym: (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitors
has_related_synonym: (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD(+) 15-oxidoreductase inhibitor
has_related_synonym: (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD(+) 15-oxidoreductase inhibitors
has_related_synonym: 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitor
has_related_synonym: 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD(+) 15-oxidoreductase inhibitors
has_related_synonym: 15-OH-PGDH inhibitor
has_related_synonym: 15-OH-PGDH inhibitors
has_related_synonym: 15-hydroxyprostaglandin dehydrogenase (NAD(+)) (EC 1.1.1.141) inhibitor
has_related_synonym: 15-hydroxyprostaglandin dehydrogenase (NAD(+)) (EC 1.1.1.141) inhibitors
has_related_synonym: 15-hydroxyprostaglandin dehydrogenase (NAD(+)) inhibitor
has_related_synonym: 15-hydroxyprostaglandin dehydrogenase (NAD(+)) inhibitors
has_related_synonym: 15-hydroxyprostaglandin dehydrogenase inhibitor
has_related_synonym: 15-hydroxyprostaglandin dehydrogenase inhibitors
has_related_synonym: 15-hydroxyprostanoic dehydrogenase inhibitor
has_related_synonym: 15-hydroxyprostanoic dehydrogenase inhibitors
has_related_synonym: EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitors
has_related_synonym: EC 1.1.1.141 inhibitor
has_related_synonym: EC 1.1.1.141 inhibitors
has_related_synonym: NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (type I) inhibitor
has_related_synonym: NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (type I) inhibitors
has_related_synonym: NAD-specific 15-hydroxyprostaglandin dehydrogenase inhibitor
has_related_synonym: NAD-specific 15-hydroxyprostaglandin dehydrogenase inhibitors
has_related_synonym: PGDH inhibitor
has_related_synonym: PGDH inhibitors
has_related_synonym: prostaglandin dehydrogenase inhibitor
has_related_synonym: prostaglandin dehydrogenase inhibitors
id: CHEBI:77108
in subset: 3 STAR

EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitor
textual definition: An EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.21.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.21.3.* inhibitor
has_related_synonym: EC 1.21.3.* inhibitors
has_related_synonym: inhibitor of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor
has_related_synonym: inhibitor of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*)
has_related_synonym: inhibitors of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor
has_related_synonym: inhibitors of oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*)
has_related_synonym: oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*) inhibitor
has_related_synonym: oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (EC 1.21.3.*) inhibitors
id: CHEBI:77109
in subset: 3 STAR

EC 1.21.3.3 (reticuline oxidase) inhibitor
type: Class
subclass of: EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor
textual definition: An EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor that interferes with the action of reticuline oxidase (EC 1.21.3.3, previously EC 1.5.3.9).
imported from: chebi.owl
has cross-reference: Wikipedia:Reticuline_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming) inhibitor
has_related_synonym: (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming) inhibitors
has_related_synonym: BBE inhibitor
has_related_synonym: BBE inhibitors
has_related_synonym: EC 1.21.3.3 (reticuline oxidase) inhibitors
has_related_synonym: EC 1.21.3.3 inhibitor
has_related_synonym: EC 1.21.3.3 inhibitors
has_related_synonym: EC 1.5.3.9 inhibitor
has_related_synonym: EC 1.5.3.9 inhibitors
has_related_synonym: berberine bridge enzyme inhibitor
has_related_synonym: berberine bridge enzyme inhibitors
has_related_synonym: berberine-bridge-forming enzyme inhibitor
has_related_synonym: berberine-bridge-forming enzyme inhibitors
has_related_synonym: reticuline oxidase (EC 1.21.3.3) inhibitor
has_related_synonym: reticuline oxidase (EC 1.21.3.3) inhibitors
has_related_synonym: reticuline oxidase inhibitor
has_related_synonym: reticuline oxidase inhibitors
has_related_synonym: tetrahydroprotoberberine synthase inhibitor
has_related_synonym: tetrahydroprotoberberine synthase inhibitors
id: CHEBI:77110
in subset: 3 STAR

EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC 2.1.1.116).
imported from: chebi.owl
has cross-reference: Wikipedia:3'-hydroxy-N-methyl-(S)-coclaurine_4'-O-methyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC 2.1.1.116) inhibitor
has_related_synonym: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC 2.1.1.116) inhibitors
has_related_synonym: EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitors
has_related_synonym: EC 2.1.1.116 inhibitor
has_related_synonym: EC 2.1.1.116 inhibitors
has_related_synonym: S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase inhibitor
has_related_synonym: S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase inhibitors
id: CHEBI:77111
in subset: 3 STAR

EC 2.7.11.10 (IkappaB kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of IkappaB kinase (EC 2.7.11.10).
imported from: chebi.owl
has cross-reference: Wikipedia:IkappaB_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:[IkappaB protein] phosphotransferase
has_related_synonym: ATP:[IkappaB protein] phosphotransferase inhibitor
has_related_synonym: CHUK inhibitor
has_related_synonym: CHUK inhibitors
has_related_synonym: EC 2.7.11.10 (IkappaB kinase) inhibitors
has_related_synonym: EC 2.7.11.10 inhibitor
has_related_synonym: EC 2.7.11.10 inhibitors
has_related_synonym: IKBKA inhibitor
has_related_synonym: IKBKA inhibitors
has_related_synonym: IKBKB inhibitor
has_related_synonym: IKBKB inhibitors
has_related_synonym: IKK inhibitor
has_related_synonym: IKK inhibitors
has_related_synonym: IKK-1 inhibitor
has_related_synonym: IKK-1 inhibitors
has_related_synonym: IKK-2 inhibitor
has_related_synonym: IKK-2 inhibitors
has_related_synonym: IkappaB kinase (EC 2.7.11.10) inhibitor
has_related_synonym: IkappaB kinase (EC 2.7.11.10) inhibitors
has_related_synonym: IkappaB kinase inhibitor
has_related_synonym: IkappaB kinase inhibitors
has_related_synonym: STK12 inhibitor
has_related_synonym: STK12 inhibitors
has_related_synonym: TANK-binding kinase 1 inhibitor
has_related_synonym: TANK-binding kinase 1 inhibitors
has_related_synonym: TBK1 inhibitor
has_related_synonym: TBK1 inhibitors
id: CHEBI:77113
in subset: 3 STAR

EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122).
imported from: chebi.owl
has cross-reference: Wikipedia:(S)-tetrahydroprotoberberine_N-methyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122) inhibitor
has_related_synonym: (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122) inhibitors
has_related_synonym: (S)-tetrahydroprotoberberine N-methyltransferase inhibitor
has_related_synonym: (S)-tetrahydroprotoberberine N-methyltransferase inhibitors
has_related_synonym: EC 2.1.1.122 ((S)-tetrahydroprotoberberine N-methyltransferase) inhibitor
has_related_synonym: EC 2.1.1.122 ((S)-tetrahydroprotoberberine N-methyltransferase) inhibitors
has_related_synonym: EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitors
has_related_synonym: EC 2.1.1.122 inhibitor
has_related_synonym: EC 2.1.1.122 inhibitors
has_related_synonym: S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase inhibitor
has_related_synonym: S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase inhibitors
has_related_synonym: tetrahydroprotoberberine cis-N-methyltransferase inhibitor
has_related_synonym: tetrahydroprotoberberine cis-N-methyltransferase inhibitors
id: CHEBI:77115
in subset: 3 STAR

EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor
type: Class
subclass of: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
textual definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any such enzyme acting on the C-N bond of nitriles (EC 3.5.5.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitors
has_related_synonym: EC 3.5.5.* inhibitor
has_related_synonym: EC 3.5.5.* inhibitors
has_related_synonym: hydrolase acting on C-N bonds in nitriles (EC 3.5.5.*) inhibitor
has_related_synonym: hydrolase acting on C-N bonds in nitriles (EC 3.5.5.*) inhibitors
has_related_synonym: inhibitor of hydrolases acting on C-N bonds in nitriles
has_related_synonym: inhibitors of hydrolases acting on C-N bonds in nitriles
id: CHEBI:77117
in subset: 3 STAR

EC 3.5.5.1 (nitrilase) inhibitor
type: Class
subclass of: EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor
textual definition: An EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor that interferes with the action of nitrilase (EC 3.5.5.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Nitrilase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.5.1 (nitrilase) inhibitors
has_related_synonym: EC 3.5.5.1 inhibitor
has_related_synonym: EC 3.5.5.1 inhibitors
has_related_synonym: acetonitrilase inhibitor
has_related_synonym: acetonitrilase inhibitors
has_related_synonym: benzonitrilase inhibitor
has_related_synonym: benzonitrilase inhibitors
has_related_synonym: nitrilase (EC 3.5.5.1) inhibitor
has_related_synonym: nitrilase (EC 3.5.5.1) inhibitors
has_related_synonym: nitrile aminohydrolase inhibitor
has_related_synonym: nitrile aminohydrolase inhibitors
id: CHEBI:77118
in subset: 3 STAR

EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of prostaglandin-E2 9-reductase (EC 1.1.1.189).
imported from: chebi.owl
has cross-reference: Wikipedia:Prostaglandin-E2_9-reductase
has_obo_namespace: chebi_ontology
has_related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitor
has_related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitors
has_related_synonym: 9-keto-prostaglandin E2 reductase inhibitor
has_related_synonym: 9-keto-prostaglandin E2 reductase inhibitors
has_related_synonym: 9-ketoprostaglandin reductase inhibitor
has_related_synonym: 9-ketoprostaglandin reductase inhibitors
has_related_synonym: EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitors
has_related_synonym: EC 1.1.1.189 inhibitor
has_related_synonym: EC 1.1.1.189 inhibitors
has_related_synonym: PGE-9-ketoreductase inhibitor
has_related_synonym: PGE-9-ketoreductase inhibitors
has_related_synonym: PGE2 9-oxoreductase inhibitor
has_related_synonym: PGE2 9-oxoreductase inhibitors
has_related_synonym: PGE2-9-OR inhibitor
has_related_synonym: PGE2-9-OR inhibitors
has_related_synonym: PGE2-9-ketoreductase inhibitor
has_related_synonym: PGE2-9-ketoreductase inhibitors
has_related_synonym: prostaglandin 9-ketoreductase inhibitor
has_related_synonym: prostaglandin 9-ketoreductase inhibitors
has_related_synonym: prostaglandin E 9-ketoreductase inhibitor
has_related_synonym: prostaglandin E 9-ketoreductase inhibitors
has_related_synonym: prostaglandin E2-9-oxoreductase inhibitor
has_related_synonym: prostaglandin E2-9-oxoreductase inhibitors
has_related_synonym: prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitor
has_related_synonym: prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitors
has_related_synonym: reductase, 15-hydroxy-9-oxoprostaglandin inhibitor
has_related_synonym: reductase, 15-hydroxy-9-oxoprostaglandin inhibitors
id: CHEBI:77119
in subset: 3 STAR

Toll-like receptor 2 agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates the Toll-like receptor 2 (TLR 2, TLR-2) protein.
imported from: chebi.owl
has cross-reference: PMID:24434326
has_obo_namespace: chebi_ontology
has_related_synonym: TLR 2 agonist
has_related_synonym: TLR 2 agonists
has_related_synonym: TLR-2 agonist
has_related_synonym: TLR-2 agonists
has_related_synonym: Toll-like receptor 2 agonists
has_related_synonym: Toll-like receptor-2 agonist
has_related_synonym: Toll-like receptor-2 agonists
id: CHEBI:77161
in subset: 3 STAR

histological dye
type: Class
subclass of: dye
textual definition: A dye used in microscopic or electron microscopic examination of cells and tissues to give contrast and to highlight particular features of interest, such as nuclei and cytoplasm.
imported from: chebi.owl
has cross-reference: PMID:21756020
has cross-reference: PMID:21838612
has cross-reference: PMID:23901948
has_obo_namespace: chebi_ontology
has_related_synonym: biological stain
has_related_synonym: biological stains
has_related_synonym: histological dyes
has_related_synonym: histological stain
has_related_synonym: histological stains
id: CHEBI:77178
in subset: 3 STAR

food colouring
type: Class
subclass of: food additive
textual definition: A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199).
imported from: chebi.owl
has cross-reference: Wikipedia:Food_coloring
has_obo_namespace: chebi_ontology
has_related_synonym: food coloring
has_related_synonym: food colorings
has_related_synonym: food colourings
id: CHEBI:77182
in subset: 3 STAR

EC 2.7.1.33 (pantothenate kinase) inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of pantothenate kinase (EC 2.7.1.33).
imported from: chebi.owl
has cross-reference: Wikipedia:Pantothenate_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:(R)-pantothenate 4'-phosphotransferase inhibitor
has_related_synonym: ATP:(R)-pantothenate 4'-phosphotransferase inhibitors
has_related_synonym: ATP:pantothenate 4'-phosphotransferase inhibitor
has_related_synonym: ATP:pantothenate 4'-phosphotransferase inhibitors
has_related_synonym: D-pantothenate kinase inhibitor
has_related_synonym: D-pantothenate kinase inhibitors
has_related_synonym: EC 2.7.1.33 (pantothenate kinase) inhibitors
has_related_synonym: EC 2.7.1.33 inhibitor
has_related_synonym: EC 2.7.1.33 inhibitors
has_related_synonym: pantothenate kinase (EC 2.7.1.33) inhibitor
has_related_synonym: pantothenate kinase (EC 2.7.1.33) inhibitors
has_related_synonym: pantothenate kinase (phosphorylating) inhibitor
has_related_synonym: pantothenate kinase (phosphorylating) inhibitors
has_related_synonym: pantothenic acid kinase inhibitor
has_related_synonym: pantothenic acid kinase inhibitors
id: CHEBI:77194
in subset: 3 STAR

EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor
type: Class
subclass of: EC 3.4.24.* (metalloendopeptidase) inhibitor
textual definition: An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83).
imported from: chebi.owl
has cross-reference: Wikipedia:Anthrax_lethal_factor_endopeptidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitors
has_related_synonym: EC 3.4.24.83 inhibitor
has_related_synonym: EC 3.4.24.83 inhibitors
has_related_synonym: anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitor
has_related_synonym: anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitors
has_related_synonym: lethal toxin inhibitor
has_related_synonym: lethal toxin inhibitors
id: CHEBI:77255
in subset: 3 STAR

cardioprotective agent
type: Class
subclass of: protective agent
textual definition: Any protective agent that is able to prevent damage to the heart.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cardioprotective agents
id: CHEBI:77307
in subset: 3 STAR

pregnane X receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates a pregnane X receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:Pregnane_X_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: PXR agonist
has_related_synonym: PXR agonists
has_related_synonym: pregnane X receptor agonists
id: CHEBI:77318
in subset: 3 STAR

UDP-glucuronosyltransferase activator
type: Class
subclass of: enzyme activator
textual definition: Any compound that activates UDP-glucuronosyltransferase (EC 2.4.1.17).
imported from: chebi.owl
has cross-reference: Wikipedia:Glucuronosyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: UDP-glucuronosyltransferase activators
id: CHEBI:77324
in subset: 3 STAR

androstane receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates androstane receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Constitutive_androstane_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: CAR agonist
has_related_synonym: CAR agonists
has_related_synonym: androstane receptor agonists
has_related_synonym: constitutive androstane receptor agonist
has_related_synonym: constitutive androstane receptor agonists
id: CHEBI:77326
in subset: 3 STAR

EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
type: Class
subclass of: EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12).
imported from: chebi.owl
has cross-reference: Wikipedia:Trypanothione-disulfide_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
has_related_synonym: EC 1.8.1.12 inhibitor
has_related_synonym: EC 1.8.1.12 inhibitors
has_related_synonym: N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor
has_related_synonym: N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors
has_related_synonym: NADPH2:trypanothione oxidoreductase inhibitor
has_related_synonym: NADPH2:trypanothione oxidoreductase inhibitors
has_related_synonym: NADPH:trypanothione oxidoreductase inhibitor
has_related_synonym: NADPH:trypanothione oxidoreductase inhibitors
has_related_synonym: trypanothione reductase inhibitor
has_related_synonym: trypanothione reductase inhibitors
has_related_synonym: trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor
has_related_synonym: trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors
has_related_synonym: trypanothione:NADP(+) oxidoreductase inhibitor
has_related_synonym: trypanothione:NADP(+) oxidoreductase inhibitors
id: CHEBI:77402
in subset: 3 STAR

EC 1.1.1.188 (prostaglandin-F synthase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of prostaglandin-F synthase (EC 1.1.1.188).
imported from: chebi.owl
has cross-reference: Wikipedia:Prostaglandin-F_synthase
has_obo_namespace: chebi_ontology
has_related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 11-oxidoreductase inhibitor
has_related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 11-oxidoreductase inhibitors
has_related_synonym: EC 1.1.1.188 (prostaglandin-F synthase) inhibitors
has_related_synonym: EC 1.1.1.188 inhibitor
has_related_synonym: EC 1.1.1.188 inhibitors
has_related_synonym: NADPH-dependent prostaglandin D2 11-keto reductase inhibitor
has_related_synonym: NADPH-dependent prostaglandin D2 11-keto reductase inhibitors
has_related_synonym: PGD2 11-ketoreductase inhibitor
has_related_synonym: PGD2 11-ketoreductase inhibitors
has_related_synonym: PGF synthetase inhibitor
has_related_synonym: PGF synthetase inhibitors
has_related_synonym: PGF2alpha synthetase inhibitor
has_related_synonym: PGF2alpha synthetase inhibitors
has_related_synonym: prostaglandin 11-keto reductase inhibitor
has_related_synonym: prostaglandin 11-keto reductase inhibitors
has_related_synonym: prostaglandin 11-ketoreductase inhibitor
has_related_synonym: prostaglandin 11-ketoreductase inhibitors
has_related_synonym: prostaglandin D2-ketoreductase inhibitor
has_related_synonym: prostaglandin D2-ketoreductase inhibitors
has_related_synonym: prostaglandin F synthase inhibitor
has_related_synonym: prostaglandin F synthase inhibitors
has_related_synonym: prostaglandin F synthetase inhibitor
has_related_synonym: prostaglandin F synthetase inhibitors
has_related_synonym: prostaglandin-D2 11-reductase inhibitor
has_related_synonym: prostaglandin-D2 11-reductase inhibitors
has_related_synonym: reductase, 15-hydroxy-11-oxoprostaglandin inhibitor
has_related_synonym: reductase, 15-hydroxy-11-oxoprostaglandin inhibitors
has_related_synonym: synthetase, prostaglandin F2alpha inhibitor
has_related_synonym: synthetase, prostaglandin F2alpha inhibitors
id: CHEBI:77425
in subset: 3 STAR

EC 1.1.1.25 (shikimate dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of shikimate dehydrogenase (EC 1.1.1.25).
imported from: chebi.owl
has cross-reference: Wikipedia:Shikimate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: 5-dehydroshikimate reductase inhibitor
has_related_synonym: 5-dehydroshikimate reductase inhibitors
has_related_synonym: 5-dehydroshikimic reductase inhibitor
has_related_synonym: 5-dehydroshikimic reductase inhibitors
has_related_synonym: AroE inhibitor
has_related_synonym: AroE inhibitors
has_related_synonym: DHS reductase inhibitor
has_related_synonym: DHS reductase inhibitors
has_related_synonym: EC 1.1.1.25 (shikimate dehydrogenase) inhibitors
has_related_synonym: EC 1.1.1.25 inhibitor
has_related_synonym: EC 1.1.1.25 inhibitors
has_related_synonym: dehydroshikimic reductase inhibitor
has_related_synonym: dehydroshikimic reductase inhibitors
has_related_synonym: shikimate 5-dehydrogenase inhibitor
has_related_synonym: shikimate 5-dehydrogenase inhibitors
has_related_synonym: shikimate dehydrogenase (EC 1.1.1.25) inhibitor
has_related_synonym: shikimate dehydrogenase (EC 1.1.1.25) inhibitors
has_related_synonym: shikimate dehydrogenase inhibitor
has_related_synonym: shikimate dehydrogenase inhibitors
has_related_synonym: shikimate oxidoreductase inhibitor
has_related_synonym: shikimate oxidoreductase inhibitors
has_related_synonym: shikimate:NADP(+) 3-oxidoreductase inhibitor
has_related_synonym: shikimate:NADP(+) 3-oxidoreductase inhibitors
has_related_synonym: shikimate:NADP(+) 5-oxidoreductase inhibitor
has_related_synonym: shikimate:NADP(+) 5-oxidoreductase inhibitors
has_related_synonym: shikimate:NADP(+) oxidoreductase inhibitor
has_related_synonym: shikimate:NADP(+) oxidoreductase inhibitors
id: CHEBI:77484
in subset: 3 STAR

bradykinin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates bradykinin receptors
imported from: chebi.owl
has cross-reference: Wikipedia:Bradykinin_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: bradykinin receptor agonists
id: CHEBI:77495
in subset: 3 STAR

bradykinin receptor B2 agonist
type: Class
subclass of: bradykinin receptor agonist
textual definition: A bradykinin agonist that binds to and activates bradykinin B2 receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Bradykinin_receptor_B2
has_obo_namespace: chebi_ontology
has_related_synonym: B2 receptor agonist
has_related_synonym: B2 receptor agonists
has_related_synonym: B2R agonist
has_related_synonym: B2R agonists
has_related_synonym: bradykinin receptor B2 agonists
id: CHEBI:77496
in subset: 3 STAR

thermal degradation product
type: Class
subclass of: chemical role
textual definition: Any product obtained as a result of thermally induced non-enzymatic degradation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: thermal artefact
has_related_synonym: thermal artefacts
has_related_synonym: thermal degradation products
id: CHEBI:77521
in subset: 3 STAR

Maillard reaction product
type: Class
subclass of: thermal degradation product
textual definition: Any thermal degradation product obtained as a result of a chemical reaction between an amino acid and a reducing sugar (Maillard reaction, a non-enzymatic browning procedure that usually imparts flavour to starch-based food products).
imported from: chebi.owl
has cross-reference: PMID:23588491
has cross-reference: PMID:23612540
has cross-reference: PMID:24246231
has cross-reference: Wikipedia:Maillard_reaction
has_obo_namespace: chebi_ontology
has_related_synonym: Maillard product
has_related_synonym: Maillard products
has_related_synonym: maillard reaction products
id: CHEBI:77523
in subset: 3 STAR

eugeroic
type: Class
subclass of: psychotropic drug
textual definition: A phsychotropic drug that improves wakefulness and alertness, and reduces tiredness, drowsiness, and the need for sleep. Eugeroics are relatively non-addictive and are used in the treatment of narcolepsy and other sleep disorders.
imported from: chebi.owl
has cross-reference: Wikipedia:Wakefulness-promoting_agent
has_obo_namespace: chebi_ontology
has_related_synonym: eugeroics
has_related_synonym: vigilance promoting agent
has_related_synonym: vigilance promoting agents
has_related_synonym: vigilance promoting drug
has_related_synonym: vigilance promoting drugs
has_related_synonym: vigilance-promoting agent
has_related_synonym: vigilance-promoting agents
has_related_synonym: vigilance-promoting drug
has_related_synonym: vigilance-promoting drugs
has_related_synonym: wake-promoting agent
has_related_synonym: wake-promoting agents
has_related_synonym: wake-promoting drug
has_related_synonym: wake-promoting drugs
has_related_synonym: wakefulness-promoting agent
has_related_synonym: wakefulness-promoting agents
has_related_synonym: wakefulness-promoting drug
has_related_synonym: wakefulness-promoting drugs
id: CHEBI:77567
in subset: 3 STAR

loop diuretic
type: Class
subclass of: diuretic
textual definition: A diuretic that acts on the ascending loop of Henle in the kidney.
imported from: chebi.owl
has cross-reference: Wikipedia:Loop_diuretic
has_obo_namespace: chebi_ontology
has_related_synonym: loop diuretics
id: CHEBI:77608
in subset: 3 STAR

EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267).
imported from: chebi.owl
has cross-reference: Wikipedia:DXP_reductoisomerase
has_obo_namespace: chebi_ontology
has_related_synonym: 1-deoxy-D-xylulose-5-phosphate isomeroreductase inhibitor
has_related_synonym: 1-deoxy-D-xylulose-5-phosphate isomeroreductase inhibitors
has_related_synonym: 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267) inhibitor
has_related_synonym: 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267) inhibitors
has_related_synonym: 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitor
has_related_synonym: 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors
has_related_synonym: 1-deoxyxylulose-5-phosphate reductoisomerase inhibitor
has_related_synonym: 1-deoxyxylulose-5-phosphate reductoisomerase inhibitors
has_related_synonym: 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerising) inhibitor
has_related_synonym: 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerising) inhibitors
has_related_synonym: 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerizing) inhibitor
has_related_synonym: 2-C-methyl-D-erythritol-4-phosphate:NADP(+) oxidoreductase (isomerizing) inhibitors
has_related_synonym: 2C-methyl-D-erythritol-4-phosphate (MEP) synthase inhibitor
has_related_synonym: 2C-methyl-D-erythritol-4-phosphate (MEP) synthase inhibitors
has_related_synonym: DXP-reductoisomerase inhibitor
has_related_synonym: DXP-reductoisomerase inhibitors
has_related_synonym: EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitors
has_related_synonym: EC 1.1.1.267 inhibitor
has_related_synonym: EC 1.1.1.267 inhibitors
id: CHEBI:77654
in subset: 3 STAR

EC 4.3.1.3 (histidine ammonia-lyase) inhibitor
type: Class
subclass of: EC 4.3.1.* (ammonia-lyase) inhibitor
textual definition: An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of histidine ammonia-lyase (EC 4.3.1.3).
imported from: chebi.owl
has cross-reference: Wikipedia:Histidine_ammonia-lyase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.3.1.3 (histidine ammonia-lyase) inhibitors
has_related_synonym: EC 4.3.1.3 inhibitor
has_related_synonym: EC 4.3.1.3 inhibitors
has_related_synonym: L-histidine ammonia-lyase (urocanate-forming) inhibitor
has_related_synonym: L-histidine ammonia-lyase (urocanate-forming) inhibitors
has_related_synonym: L-histidine ammonia-lyase inhibitor
has_related_synonym: L-histidine ammonia-lyase inhibitors
has_related_synonym: histidase inhibitor
has_related_synonym: histidase inhibitors
has_related_synonym: histidinase inhibitor
has_related_synonym: histidinase inhibitors
has_related_synonym: histidine alpha-deaminase inhibitor
has_related_synonym: histidine alpha-deaminase inhibitors
has_related_synonym: histidine ammonia-lyase (EC 4.3.1.3) inhibitor
has_related_synonym: histidine ammonia-lyase (EC 4.3.1.3) inhibitors
has_related_synonym: histidine ammonia-lyase inhibitor
has_related_synonym: histidine ammonia-lyase inhibitors
id: CHEBI:77703
in subset: 3 STAR

EC 3.4.19.* (omega-peptidase) inhibitor
type: Class
subclass of: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
textual definition: Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the action of any omega-peptidase (EC 3.4.19.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.19.* (omega-peptidase) inhibitors
has_related_synonym: EC 3.4.19.* inhibitor
has_related_synonym: EC 3.4.19.* inhibitors
has_related_synonym: omega-peptidase (EC 3.4.19.*) inhibitor
has_related_synonym: omega-peptidase (EC 3.4.19.*) inhibitors
has_related_synonym: omega-peptidase inhibitor
has_related_synonym: omega-peptidase inhibitors
id: CHEBI:77705
in subset: 3 STAR

EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
type: Class
subclass of: EC 3.4.19.* (omega-peptidase) inhibitor
textual definition: An EC 3.4.19.* (omega-peptidase) inhibitor that interferes with the action of pyroglutamyl-peptidase I (EC 3.4.19.3).
imported from: chebi.owl
has cross-reference: Wikipedia:Pyroglutamyl-peptidase_I
has_obo_namespace: chebi_ontology
has_related_synonym: 5-oxoprolyl-peptidase inhibitors
has_related_synonym: EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitors
has_related_synonym: EC 3.4.19.3 inhibitor
has_related_synonym: EC 3.4.19.3 inhibitors
has_related_synonym: L-pyroglutamyl peptide hydrolase inhibitor
has_related_synonym: L-pyroglutamyl peptide hydrolase inhibitors
has_related_synonym: L-pyrrolidonecarboxylate peptidase inhibitor
has_related_synonym: L-pyrrolidonecarboxylate peptidase inhibitors
has_related_synonym: pyrase inhibitor
has_related_synonym: pyrase inhibitors
has_related_synonym: pyroglutamate aminopeptidase inhibitor
has_related_synonym: pyroglutamate aminopeptidase inhibitors
has_related_synonym: pyroglutamidase inhibitor
has_related_synonym: pyroglutamidase inhibitors
has_related_synonym: pyroglutamyl aminopeptidase inhibitor
has_related_synonym: pyroglutamyl aminopeptidase inhibitors
has_related_synonym: pyroglutamyl-peptidase I (EC 3.4.19.3) inhibitor
has_related_synonym: pyroglutamyl-peptidase I (EC 3.4.19.3) inhibitors
has_related_synonym: pyroglutamyl-peptidase I inhibitor
has_related_synonym: pyroglutamyl-peptidase I inhibitors
has_related_synonym: pyrrolidone-carboxyl peptidase inhibitor
has_related_synonym: pyrrolidone-carboxyl peptidase inhibitors
has_related_synonym: pyrrolidonecarboxylyl peptidase inhibitor
has_related_synonym: pyrrolidonecarboxylyl peptidase inhibitors
has_related_synonym: pyrrolidonyl peptidase inhibitor
has_related_synonym: pyrrolidonyl peptidase inhibitors5-oxoprolyl-peptidase inhibitor
id: CHEBI:77706
in subset: 3 STAR

nasal decongestant
type: Class
subclass of: drug
textual definition: A drug used to relieve nasal congestion in the upper respiratory tract.
imported from: chebi.owl
has cross-reference: Wikipedia:Decongestant
has_obo_namespace: chebi_ontology
has_related_synonym: decongestant
has_related_synonym: decongestants
has_related_synonym: nasal decongestants
id: CHEBI:77715
in subset: 3 STAR

p53 activator
type: Class
subclass of: activator
textual definition: Any activator of tumour protein p53.
imported from: chebi.owl
has cross-reference: Wikipedia:P53
has_obo_namespace: chebi_ontology
has_related_synonym: cellular tumor antigen p53 activator
has_related_synonym: cellular tumor antigen p53 activators
has_related_synonym: p53 activators
has_related_synonym: phosphoprotein p53 activator
has_related_synonym: phosphoprotein p53 activators
has_related_synonym: tumor protein p53 activator
has_related_synonym: tumor protein p53 activators
has_related_synonym: tumour protein p53 activator
has_related_synonym: tumour protein p53 activators
has_related_synonym: tumour suppressor p53 activator
has_related_synonym: tumour suppressor p53 activators
id: CHEBI:77731
in subset: 3 STAR

EC 3.4.24.18 (meprin A) inhibitor
type: Class
subclass of: EC 3.4.24.* (metalloendopeptidase) inhibitor
textual definition: An EC 3.4.24.* (metalloendopeptidase) inhibitor that inhibits the action of meprin A (EC 3.4.24.18).
imported from: chebi.owl
has cross-reference: Wikipedia:Meprin_A
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.24.18 (meprin A) inhibitors
has_related_synonym: EC 3.4.24.18 inhibitor
has_related_synonym: EC 3.4.24.18 inhibitors
has_related_synonym: N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitor
has_related_synonym: N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitors
has_related_synonym: PABA-peptide hydrolase inhibitor
has_related_synonym: PABA-peptide hydrolase inhibitors
has_related_synonym: PPH inhibitor
has_related_synonym: PPH inhibitors
has_related_synonym: endopeptidase-2 inhibitor
has_related_synonym: endopeptidase-2 inhibitors
has_related_synonym: meprin A (EC 3.4.24.18) inhibitor
has_related_synonym: meprin A (EC 3.4.24.18) inhibitors
has_related_synonym: meprin A inhibitor
has_related_synonym: meprin A inhibitors
has_related_synonym: meprin inhibitor
has_related_synonym: meprin inhibitors
has_related_synonym: meprin-a inhibitor
has_related_synonym: meprin-a inhibitors
id: CHEBI:77745
in subset: 3 STAR

human metabolite
type: Class
subclass of: mammalian metabolite
textual definition: Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
imported from: chebi.owl
has_alternative_id: CHEBI:75770
has_alternative_id: CHEBI:77123
has_obo_namespace: chebi_ontology
has_related_synonym: H. sapiens metabolite
has_related_synonym: H. sapiens metabolites
has_related_synonym: Homo sapiens metabolite
has_related_synonym: Homo sapiens metabolites
id: CHEBI:77746
in subset: 3 STAR

EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
textual definition: An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of phospholipid-translocating ATPase (EC 3.6.3.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Phospholipid-translocating_ATPase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP phosphohydrolase (phospholipid-flipping) inhibitor
has_related_synonym: ATP phosphohydrolase (phospholipid-flipping) inhibitors
has_related_synonym: EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitors
has_related_synonym: EC 3.6.3.1 inhibitor
has_related_synonym: EC 3.6.3.1 inhibitors
has_related_synonym: Mg(2)(+)-ATPase inhibitor
has_related_synonym: Mg(2)(+)-ATPase inhibitors
has_related_synonym: aminophospholipid-transporting ATPase inhibitor
has_related_synonym: aminophospholipid-transporting ATPase inhibitors
has_related_synonym: flippase inhibitor
has_related_synonym: flippase inhibitors
has_related_synonym: magnesium-ATPase inhibitor
has_related_synonym: magnesium-ATPase inhibitors
has_related_synonym: phospholipid-translocating ATPase (EC 3.6.3.1) inhibitor
has_related_synonym: phospholipid-translocating ATPase (EC 3.6.3.1) inhibitors
has_related_synonym: phospholipid-translocating ATPase inhibitor
has_related_synonym: phospholipid-translocating ATPase inhibitors
has_related_synonym: phospholipid-transporting ATPase inhibitor
has_related_synonym: phospholipid-transporting ATPase inhibitors
id: CHEBI:77747
in subset: 3 STAR

EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
type: Class
subclass of: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
textual definition: An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44).
imported from: chebi.owl
has cross-reference: Wikipedia:Xenobiotic-transporting_ATPase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP phosphohydrolase (steroid-exporting) inhibitor
has_related_synonym: ATP phosphohydrolase (steroid-exporting) inhibitors
has_related_synonym: ATP phosphohydrolase (xenobiotic-exporting) inhibitor
has_related_synonym: ATP phosphohydrolase (xenobiotic-exporting) inhibitors
has_related_synonym: EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitors
has_related_synonym: EC 3.6.3.44 inhibitor
has_related_synonym: EC 3.6.3.44 inhibitors
has_related_synonym: MDR protein inhibitor
has_related_synonym: MDR protein inhibitors
has_related_synonym: P-glycoprotein inhibitor
has_related_synonym: P-glycoprotein inhibitors
has_related_synonym: PDR protein inhibitor
has_related_synonym: PDR protein inhibitors
has_related_synonym: multidrug-resistance protein inhibitor
has_related_synonym: multidrug-resistance protein inhibitors
has_related_synonym: pleiotropic-drug-resistance protein inhibitor
has_related_synonym: pleiotropic-drug-resistance protein inhibitors
has_related_synonym: steroid-transporting ATPase inhibitor
has_related_synonym: steroid-transporting ATPase inhibitors
has_related_synonym: xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor
has_related_synonym: xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitors
has_related_synonym: xenobiotic-transporting ATPase inhibitor
has_related_synonym: xenobiotic-transporting ATPase inhibitors
id: CHEBI:77748
in subset: 3 STAR

ATP/ADP translocase inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of the trasporter protein ATP/ADP translocase.
imported from: chebi.owl
has cross-reference: Wikipedia:ATP-ADP_translocase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP-ADP translocase inhibitor
has_related_synonym: ATP-ADP translocase inhibitors
has_related_synonym: ATP/ADP translocase inhibitors
id: CHEBI:77750
in subset: 3 STAR

EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor
type: Class
subclass of: EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
textual definition: An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of a 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53).
imported from: chebi.owl
has cross-reference: Wikipedia:3',5'-cyclic-AMP_phosphodiesterase
has_obo_namespace: chebi_ontology
has_related_synonym: 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitor
has_related_synonym: 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitors
has_related_synonym: 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitor
has_related_synonym: 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitors
has_related_synonym: 3',5'-cyclic-AMP phosphodiesterase inhibitor
has_related_synonym: 3',5'-cyclic-AMP phosphodiesterase inhibitors
has_related_synonym: EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitors
has_related_synonym: EC 3.1.4.53 inhibitor
has_related_synonym: EC 3.1.4.53 inhibitors
has_related_synonym: cAMP-specific PDE inhibitor
has_related_synonym: cAMP-specific PDE inhibitors
has_related_synonym: cAMP-specific phosphodiesterase inhibitor
has_related_synonym: cAMP-specific phosphodiesterase inhibitors
id: CHEBI:77758
in subset: 3 STAR

EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor
type: Class
subclass of: EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 1-pyrroline dehydrogenase inhibitor
has_related_synonym: 1-pyrroline dehydrogenase inhibitors
has_related_synonym: 1-pyrroline-5-carboxylate dehydrogenase inhibitor
has_related_synonym: 1-pyrroline-5-carboxylate dehydrogenase inhibitors
has_related_synonym: 1-pyrroline-5-carboxylate:NAD(+) oxidoreductase inhibitor
has_related_synonym: 1-pyrroline-5-carboxylate:NAD(+) oxidoreductase inhibitors
has_related_synonym: Delta(1)-pyrroline-5-carboxylate dehydrogenase inhibitor
has_related_synonym: Delta(1)-pyrroline-5-carboxylate dehydrogenase inhibitors
has_related_synonym: Delta(1)-pyrroline-5-carboxylic acid dehydrogenase inhibitor
has_related_synonym: Delta(1)-pyrroline-5-carboxylic acid dehydrogenase inhibitors
has_related_synonym: EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitors
has_related_synonym: EC 1.2.1.88 inhibitor
has_related_synonym: EC 1.2.1.88 inhibitors
has_related_synonym: L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) inhibitor
has_related_synonym: L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) inhibitors
has_related_synonym: L-glutamate gamma-semialdehyde dehydrogenase inhibitor
has_related_synonym: L-glutamate gamma-semialdehyde dehydrogenase inhibitors
has_related_synonym: L-glutamate gamma-semialdehyde:NAD(+) oxidoreductase inhibitor
has_related_synonym: L-glutamate gamma-semialdehyde:NAD(+) oxidoreductase inhibitors
has_related_synonym: L-pyrroline-5-carboxylate-NAD(+) oxidoreductase inhibitor
has_related_synonym: L-pyrroline-5-carboxylate-NAD(+) oxidoreductase inhibitors
has_related_synonym: pyrroline-5-carboxylate dehydrogenase inhibitor
has_related_synonym: pyrroline-5-carboxylate dehydrogenase inhibitors
has_related_synonym: pyrroline-5-carboxylic acid dehydrogenase inhibitor
has_related_synonym: pyrroline-5-carboxylic acid dehydrogenase inhibitors
id: CHEBI:77763
in subset: 3 STAR

sulfaphenazole
type: Class
subclass of: molecular entity
textual definition: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.
imported from: chebi.owl
charge: 0
formula: C15H14N4O2S
inchi: InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
inchikey: QWCJHSGMANYXCW-UHFFFAOYSA-N
mass: 314.36200
monoisotopicmass: 314.08375
smiles: Nc1ccc(cc1)S(=O)(=O)Nc1ccnn1-c1ccccc1
has cross-reference: CAS:526-08-9
has cross-reference: DrugBank:DB06729
has cross-reference: Drug_Central:2523
has cross-reference: HMDB:HMDB0015667
has cross-reference: KEGG:D01954
has cross-reference: LINCS:LSM-5279
has cross-reference: PMID:13873771
has cross-reference: PMID:18845175
has cross-reference: PMID:22785021
has cross-reference: PMID:24519941
has cross-reference: PMID:9864343
has cross-reference: Patent:US2858309
has cross-reference: Reaxys:308518
has cross-reference: Wikipedia:Sulfaphenazole
alternative_term: 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
has_obo_namespace: chebi_ontology
has_related_synonym: 1-phenyl-5-sulfanilamidopyrazole
has_related_synonym: 3-(p-aminobenzenesulfonamido)-2-phenylpyrazole
has_related_synonym: 5-sulfanilamido-1-phenylpyrazole
has_related_synonym: N'-(1-phenylpyrazol-5-yl)sulfanilamide
has_related_synonym: N(1)-(1-phenylpyrazol-5-yl)sulfanilamide
has_related_synonym: Sulfabid
has_related_synonym: sulfafenazol
has_related_synonym: sulfaphenazol
has_related_synonym: sulfaphenazole
has_related_synonym: sulfaphenazolum
has_related_synonym: sulphaphenazole
id: CHEBI:77780
in subset: 3 STAR

EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of 13-deoxydaunorubicin hydroxylase (EC 1.14.13.181).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 13-deoxydaunorubicin hydroxylase (EC 1.14.13.181) inhibitor
has_related_synonym: 13-deoxydaunorubicin hydroxylase (EC 1.14.13.181) inhibitors
has_related_synonym: 13-deoxydaunorubicin hydroxylase inhibitor
has_related_synonym: 13-deoxydaunorubicin hydroxylase inhibitors
has_related_synonym: 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating) inhibitor
has_related_synonym: 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating) inhibitors
has_related_synonym: DoxA inhibitor
has_related_synonym: DoxA inhibitors
has_related_synonym: EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitors
has_related_synonym: EC 1.14.13.181 inhibitor
has_related_synonym: EC 1.14.13.181 inhibitors
id: CHEBI:77781
in subset: 3 STAR

EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of quinine 3-monooxygenase (EC 1.14.13.67).
imported from: chebi.owl
has cross-reference: Wikipedia:Quinine_3-monooxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.13.67 (quinine 3-monooxygenase) inhibitors
has_related_synonym: EC 1.14.13.67 inhibitor
has_related_synonym: EC 1.14.13.67 inhibitors
has_related_synonym: quinine 3-hydroxylase inhibitor
has_related_synonym: quinine 3-hydroxylase inhibitors
has_related_synonym: quinine 3-monooxygenase (EC 1.14.13.67) inhibitor
has_related_synonym: quinine 3-monooxygenase (EC 1.14.13.67) inhibitors
has_related_synonym: quinine 3-monooxygenase inhibitor
has_related_synonym: quinine 3-monooxygenase inhibitors
has_related_synonym: quinine,NADPH:oxygen oxidoreductase inhibitor
has_related_synonym: quinine,NADPH:oxygen oxidoreductase inhibitors
id: CHEBI:77783
in subset: 3 STAR

persistent organic pollutant
type: Class
subclass of: environmental contaminant
textual definition: Any environmental contaminant that is resistant to environmental degradation through photolytic, biological or chemical processes. Such substances can have significant impact on health and the environment, as they persist in the environment, bioaccumulate in animal tissue and so biomagnify in food chains.
imported from: chebi.owl
has cross-reference: Wikipedia:Persistant_organic_pollutant
has_obo_namespace: chebi_ontology
has_related_synonym: POP
has_related_synonym: POPs
has_related_synonym: persistent organic pollutants
id: CHEBI:77853
in subset: 3 STAR

EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor
type: Class
subclass of: EC 4.3.1.* (ammonia-lyase) inhibitor
textual definition: An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of diaminopropionate ammonia-lyase (EC 4.3.1.15).
imported from: chebi.owl
has cross-reference: Wikipedia:Diaminopropionate_ammonia-lyase
has_obo_namespace: chebi_ontology
has_related_synonym: 2,3-diaminopropanoate ammonia-lyase (adding H2O; pyruvate-forming) inhibitor
has_related_synonym: 2,3-diaminopropanoate ammonia-lyase (adding H2O; pyruvate-forming) inhibitors
has_related_synonym: 2,3-diaminopropanoate ammonia-lyase (adding water; pyruvate-forming) inhibitor
has_related_synonym: 2,3-diaminopropanoate ammonia-lyase (adding water; pyruvate-forming) inhibitors
has_related_synonym: 2,3-diaminopropanoate ammonia-lyase inhibitor
has_related_synonym: 2,3-diaminopropanoate ammonia-lyase inhibitors
has_related_synonym: 2,3-diaminopropionate ammonia-lyase inhibitor
has_related_synonym: 2,3-diaminopropionate ammonia-lyase inhibitors
has_related_synonym: EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitors
has_related_synonym: EC 4.3.1.15 inhibitor
has_related_synonym: EC 4.3.1.15 inhibitors
has_related_synonym: alpha,beta-diaminopropionate ammonia-lyase inhibitor
has_related_synonym: alpha,beta-diaminopropionate ammonia-lyase inhibitors
has_related_synonym: diaminopropionatase inhibitor
has_related_synonym: diaminopropionatase inhibitors
has_related_synonym: diaminopropionate ammonia-lyase (EC 4.3.1.15) inhibitor
has_related_synonym: diaminopropionate ammonia-lyase (EC 4.3.1.15) inhibitors
has_related_synonym: diaminopropionate ammonia-lyase inhibitor
has_related_synonym: diaminopropionate ammonia-lyase inhibitors
id: CHEBI:77881
in subset: 3 STAR

EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
subclass of: sterol demethylation inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14alpha-demethylase).
imported from: chebi.owl
has cross-reference: Wikipedia:Sterol_14-demethylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitors
has_related_synonym: EC 1.14.13.70 inhibitor
has_related_synonym: EC 1.14.13.70 inhibitors
has_related_synonym: cytochrome P450 51 inhibitor
has_related_synonym: cytochrome P450 51 inhibitors
has_related_synonym: lanosterol 14-demethylase inhibitor
has_related_synonym: lanosterol 14-demethylase inhibitors
has_related_synonym: lanosterol 14alpha-demethylase inhibitor
has_related_synonym: lanosterol 14alpha-demethylase inhibitors
has_related_synonym: obtusufoliol 14-demethylase inhibitor
has_related_synonym: obtusufoliol 14-demethylase inhibitors
has_related_synonym: sterol 14-demethylase inhibitor
has_related_synonym: sterol 14-demethylase inhibitors
has_related_synonym: sterol 14alpha-demethylase inhibitor
has_related_synonym: sterol 14alpha-demethylase inhibitors
has_related_synonym: sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitor
has_related_synonym: sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitors
id: CHEBI:77884
in subset: 3 STAR

EC 3.5.1.4 (amidase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Amidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.4 (amidase) inhibitors
has_related_synonym: EC 3.5.1.4 inhibitor
has_related_synonym: EC 3.5.1.4 inhibitors
has_related_synonym: N-acetylaminohydrolase inhibitor
has_related_synonym: N-acetylaminohydrolase inhibitors
has_related_synonym: acylamidase inhibitor
has_related_synonym: acylamidase inhibitors
has_related_synonym: acylamide amidohydrolase inhibitor
has_related_synonym: acylamide amidohydrolase inhibitors
has_related_synonym: amidase (EC 3.5.1.4) inhibitor
has_related_synonym: amidase (EC 3.5.1.4) inhibitors
has_related_synonym: amidase inhibitor
has_related_synonym: amidase inhibitors
has_related_synonym: amidohydrolase inhibitor
has_related_synonym: amidohydrolase inhibitors
has_related_synonym: deaminase inhibitor
has_related_synonym: deaminase inhibitors
has_related_synonym: fatty acylamidase inhibitor
has_related_synonym: fatty acylamidase inhibitors
id: CHEBI:77941
in subset: 3 STAR

EC 6.1.1.4 (leucine--tRNA ligase) inhibitor
type: Class
subclass of: EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor
textual definition: An EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor that inhibits the action of leucine--tRNA synthetase (EC 6.1.1.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Leucyl-tRNA_synthetase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.1.1.4 (leucine--tRNA ligase) inhibitors
has_related_synonym: EC 6.1.1.4 inhibitor
has_related_synonym: EC 6.1.1.4 inhibitors
has_related_synonym: L-leucine:tRNA(Leu) ligase (AMP-forming) inhibitor
has_related_synonym: L-leucine:tRNA(Leu) ligase (AMP-forming) inhibitors
has_related_synonym: leucine translase inhibitor
has_related_synonym: leucine translase inhibitors
has_related_synonym: leucine--tRNA ligase inhibitor
has_related_synonym: leucine--tRNA ligase inhibitors
has_related_synonym: leucine--tRNA synthetase inhibitor
has_related_synonym: leucine--tRNA synthetase inhibitors
has_related_synonym: leucyl--tRNA synthetase inhibitor
has_related_synonym: leucyl--tRNA synthetase inhibitors
has_related_synonym: leucyl-transfer RNA synthetase inhibitor
has_related_synonym: leucyl-transfer RNA synthetase inhibitors
has_related_synonym: leucyl-transfer ribonucleate synthetase inhibitor
has_related_synonym: leucyl-transfer ribonucleate synthetase inhibitors
has_related_synonym: leucyl-transfer ribonucleic acid synthetase inhibitor
has_related_synonym: leucyl-transfer ribonucleic acid synthetase inhibitors
id: CHEBI:77953
in subset: 3 STAR

food firming agent
type: Class
subclass of: food additive
textual definition: A food additive that is used to make or keep fruit or vegetable tissues firm and crisp. or which interacts with gelling agents such as pectin to produce or strengthen a gel.
imported from: chebi.owl
has cross-reference: Wikipedia:Firming_agent
has_obo_namespace: chebi_ontology
has_related_synonym: firming agent
has_related_synonym: firming agents
has_related_synonym: food firming agents
id: CHEBI:77960
in subset: 3 STAR

food antioxidant
type: Class
subclass of: antioxidant
subclass of: food preservative
textual definition: An antioxidant that used as a food additives to help guard against food deterioration.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food antioxidants
id: CHEBI:77962
in subset: 3 STAR

sequestrant
type: Class
subclass of: chelator
subclass of: food preservative
textual definition: A food preservative that acts by chelating with metal cations (particularly those of copper, iron and nickel) that catalyse the oxidation of fats in food.
imported from: chebi.owl
has cross-reference: Wikipedia:Sequestrant
has_obo_namespace: chebi_ontology
has_related_synonym: sequestrants
id: CHEBI:77963
in subset: 3 STAR

anticaking agent
type: Class
subclass of: application
textual definition: A substance added to powdered or granulated materials in order to prevent the formation of lumps and so facilitate its packaging or transport.
imported from: chebi.owl
has cross-reference: Wikipedia:Anti-caking_agent
has_obo_namespace: chebi_ontology
has_related_synonym: anti-caking agent
has_related_synonym: anti-caking agents
has_related_synonym: anticaking agents
id: CHEBI:77964
in subset: 3 STAR

food anticaking agent
type: Class
subclass of: food additive
subclass of: anticaking agent
textual definition: An anticaking agent that is used to reduced the tendency of particles of food to adhere to one another.
imported from: chebi.owl
alternative_term: food anticaking agent
has_obo_namespace: chebi_ontology
has_related_synonym: food anti-caking agent
has_related_synonym: food anti-caking agents
id: CHEBI:77965
in subset: 3 STAR

food stabiliser
type: Class
subclass of: food additive
textual definition: A food additive that is used to preserve the structure of food.
imported from: chebi.owl
has cross-reference: Wikipedia:Stabiliser_(food)
has_obo_namespace: chebi_ontology
has_related_synonym: food stabilisers
has_related_synonym: food stabilizer
has_related_synonym: food stabilizers
has_related_synonym: stabiliser
has_related_synonym: stabilisers
has_related_synonym: stabilizer
has_related_synonym: stabilizers
id: CHEBI:77966
in subset: 3 STAR

humectant
type: Class
subclass of: application
textual definition: A compound that is used to keep a substance moist.
imported from: chebi.owl
has cross-reference: Wikipedia:humectant
has_obo_namespace: chebi_ontology
has_related_synonym: humectants
id: CHEBI:77968
in subset: 3 STAR

food humectant
type: Class
subclass of: food additive
subclass of: humectant
textual definition: A humectant that is used as a food additive to prevent foodstuffs from drying out.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food humectants
id: CHEBI:77969
in subset: 3 STAR

food thickening agent
type: Class
subclass of: food additive
textual definition: A food additive that is used to increase the viscosity of foodstuffs.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food thickening agents
has_related_synonym: thickening agent
has_related_synonym: thickening agents
id: CHEBI:77970
in subset: 3 STAR

raising agent
type: Class
subclass of: food additive
textual definition: A food additive which liberates gas so as to increase the volume of a dough or batter, resulting in a lighter and softer finished product.
imported from: chebi.owl
has cross-reference: Wikipedia:Leavening_agent
has_obo_namespace: chebi_ontology
has_related_synonym: food raising agent
has_related_synonym: food raising agents
has_related_synonym: leavening agent
has_related_synonym: leavening agents
has_related_synonym: raising agents
id: CHEBI:77971
in subset: 3 STAR

food glazing agent
type: Class
subclass of: food additive
textual definition: A food additive that is applied to the external surface or a food in order to give a smooth shiny appearance and/or to provide a protective coating to foodstuffs.
imported from: chebi.owl
has cross-reference: Wikipedia:Glazing_agent
has_obo_namespace: chebi_ontology
has_related_synonym: food glazing agents
has_related_synonym: glazing agent
has_related_synonym: glazing agents
id: CHEBI:77972
in subset: 3 STAR

antifoaming agent
type: Class
subclass of: application
textual definition: A substance that reduces and hinders the formation of foam in solutions and other liquids during their industrial or laboratory processing.
imported from: chebi.owl
has cross-reference: Wikipedia:Defoamer
has_obo_namespace: chebi_ontology
has_related_synonym: antifoaming agents
has_related_synonym: defoamer
has_related_synonym: defoamers
id: CHEBI:77973
in subset: 3 STAR

food packaging gas
type: Class
subclass of: food additive
textual definition: A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
imported from: chebi.owl
has cross-reference: Wikipedia:Packaging_gas
has_obo_namespace: chebi_ontology
has_related_synonym: food packaging gases
id: CHEBI:77974
in subset: 3 STAR

food bleaching agent
type: Class
subclass of: bleaching agent
subclass of: food additive
textual definition: A food additive that is used for the purpose of decolourising food.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food bleaching agents
id: CHEBI:78003
in subset: 3 STAR

food bulking agent
type: Class
subclass of: food additive
textual definition: A food additive that contributes to the bulk of a food without significantly contributing to its available energy value.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: filler
has_related_synonym: fillers
has_related_synonym: food bulking agents
id: CHEBI:78004
in subset: 3 STAR

food colour retention agent
type: Class
subclass of: food additive
textual definition: A food additive that intensifies, retains or stabilises the colour of a food.
imported from: chebi.owl
has cross-reference: Wikipedia:Colour_retention_agent
has_obo_namespace: chebi_ontology
has_related_synonym: color retention agent
has_related_synonym: color retention agents
has_related_synonym: colour retention agent
has_related_synonym: colour retention agents
has_related_synonym: food color retention agent
has_related_synonym: food color retention agents
has_related_synonym: food colour retention agents
id: CHEBI:78006
in subset: 3 STAR

foaming agent
type: Class
subclass of: food additive
textual definition: A food additive that makes it possible to form or maintain a uniform dispersion of a gaseous phase in a liquid or solid phase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: foaming agents
id: CHEBI:78007
in subset: 3 STAR

Wiskott-Aldrich syndrome protein inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of Wiskott-Aldrich syndrome protein.
imported from: chebi.owl
has cross-reference: Wikipedia:Wiskott-Aldrich_syndrome_protein
has_obo_namespace: chebi_ontology
has_related_synonym: N-WASP inhibitor
has_related_synonym: N-WASP inhibitors
has_related_synonym: WASP inhibitor
has_related_synonym: WASP inhibitors
has_related_synonym: Wiskott-Aldrich syndrome protein inhibitors
id: CHEBI:78009
in subset: 3 STAR

food gelling agent
type: Class
subclass of: food additive
textual definition: A food additive that enhances the texture of a foodstuff by gel formation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food gelling agents
id: CHEBI:78016
in subset: 3 STAR

food propellant
type: Class
subclass of: food additive
subclass of: propellant
textual definition: A propellant that is used to expel foods from an aerosol container.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food propellants
id: CHEBI:78017
in subset: 3 STAR

EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of adenosylmethionine decarboxylase (EC 4.1.1.50).
imported from: chebi.owl
has cross-reference: Wikipedia:Adenosylmethionine_decarboxylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitors
has_related_synonym: EC 4.1.1.50 inhibitor
has_related_synonym: EC 4.1.1.50 inhibitors
has_related_synonym: S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] inhibitor
has_related_synonym: S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] inhibitors
has_related_synonym: S-adenosyl-L-methionine carboxy-lyase [S-adenosyl 3-(methylthio)propylamine-forming] inhibitor
has_related_synonym: S-adenosyl-L-methionine carboxy-lyase [S-adenosyl 3-(methylthio)propylamine-forming] inhibitors
has_related_synonym: S-adenosyl-L-methionine carboxy-lyase inhibitor
has_related_synonym: S-adenosyl-L-methionine carboxy-lyase inhibitors
has_related_synonym: S-adenosyl-L-methionine decarboxylase inhibitor
has_related_synonym: S-adenosyl-L-methionine decarboxylase inhibitors
has_related_synonym: S-adenosylmethionine decarboxylase inhibitor
has_related_synonym: S-adenosylmethionine decarboxylase inhibitors
id: CHEBI:78024
in subset: 3 STAR

Wnt signalling inhibitor
type: Class
subclass of: inhibitor
textual definition: A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Wnt signaling inhibitor
has_related_synonym: Wnt signaling inhibitors
has_related_synonym: Wnt signalling inhibitors
has_related_synonym: Wnt-signaling inhibitor
has_related_synonym: Wnt-signaling inhibitors
has_related_synonym: Wnt-signalling inhibitor
has_related_synonym: Wnt-signalling inhibitors
id: CHEBI:78031
in subset: 3 STAR

food antifoaming agent
type: Class
subclass of: food additive
subclass of: antifoaming agent
textual definition: A food additive that is used to reduce or prevent foaming during the processing or manufacture of foodstuffs.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: food antifoaming agents
has_related_synonym: food defoamer
has_related_synonym: food defoamers
id: CHEBI:78058
in subset: 3 STAR

food additive carrier
type: Class
subclass of: food additive
textual definition: A food additive that is used to dilute, disperse or dissolve a food additive or nutrient without altering its function. Carriers are used to facilitate the handling or use of the food additive or nutrient.
imported from: chebi.owl
has_alternative_id: CHEBI:78005
has_obo_namespace: chebi_ontology
has_related_synonym: carrier
has_related_synonym: carriers
has_related_synonym: food additive carriers
id: CHEBI:78059
in subset: 3 STAR

enzyme mimic
type: Class
subclass of: application
textual definition: Any small molecule that mimics the action of an enzyme.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: enzyme mimetic
has_related_synonym: enzyme mimetics
has_related_synonym: enzyme mimics
id: CHEBI:78152
in subset: 3 STAR

oxazepam
type: Class
subclass of: molecular entity
textual definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
imported from: chebi.owl
charge: 0
formula: C15H11ClN2O2
inchi: InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)
inchikey: ADIMAYPTOBDMTL-UHFFFAOYSA-N
mass: 286.71300
monoisotopicmass: 286.05091
smiles: OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O
has cross-reference: CAS:604-75-1
has cross-reference: DrugBank:DB00842
has cross-reference: Drug_Central:2015
has cross-reference: HMDB:HMDB0014980
has cross-reference: KEGG:C07359
has cross-reference: KEGG:D00464
has cross-reference: PMID:17456431
has cross-reference: PMID:9811432
has cross-reference: Patent:CN1543961
has cross-reference: Reaxys:754065
has cross-reference: Wikipedia:Oxazepam
alternative_term: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
alternative_term: Oxazepam
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-Oxazepam
has_related_synonym: (RS)-Oxazepam
has_related_synonym: Serax
has_related_synonym: Tazepam
id: CHEBI:7823
in subset: 3 STAR

vitamin B1 antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist which acts by inhibiting the action of vitamin B1
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin B1 antagonists
id: CHEBI:78248
in subset: 3 STAR

food component
type: Class
subclass of: physiological role
textual definition: A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: dietary component
has_related_synonym: dietary components
has_related_synonym: food components
id: CHEBI:78295
in subset: 3 STAR

environmental contaminant
type: Class
subclass of: chemical role
textual definition: Any minor or unwanted substance introduced into the environment that can have undesired effects.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: environmental contaminants
id: CHEBI:78298
in subset: 3 STAR

environmental food contaminant
type: Class
subclass of: food component
subclass of: environmental contaminant
textual definition: Any unwanted chemical in food. The term includes agrochemicals and industrial chemicals that may contaminate foodstuffs during their production, transportation or storage.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: environmental food contaminants
id: CHEBI:78299
in subset: 3 STAR

lichen metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite that is produced during a metabolite reaction in lichens (composite organisms consisting of a fungus and a photosynthetic partner co-existing in a symbiotic relationship).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: lichen metabolites
id: CHEBI:78361
in subset: 3 STAR

EC 2.7.1.1 (hexokinase) inhibitor
type: Class
subclass of: lipid kinase inhibitor
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of hexokinase, EC 2.7.1.1, an enzyme that phosphorylates hexoses forming hexose phosphate.
imported from: chebi.owl
has cross-reference: Wikipedia:Hexokinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP-dependent hexokinase inhibitor
has_related_synonym: ATP-dependent hexokinase inhibitors
has_related_synonym: ATP:D-hexose 6-phosphotransferase inhibitor
has_related_synonym: ATP:D-hexose 6-phosphotransferase inhibitors
has_related_synonym: EC 2.7.1.1 (hexokinase) inhibitors
has_related_synonym: EC 2.7.1.1 inhibitor
has_related_synonym: EC 2.7.1.1 inhibitors
has_related_synonym: glucose ATP phosphotransferase inhibitor
has_related_synonym: glucose ATP phosphotransferase inhibitors
has_related_synonym: hexokinase (phosphorylating) inhibitor
has_related_synonym: hexokinase (phosphorylating) inhibitors
has_related_synonym: hexokinase D inhibitor
has_related_synonym: hexokinase D inhibitors
has_related_synonym: hexokinase inhibitor
has_related_synonym: hexokinase inhibitors
has_related_synonym: hexokinase type I inhibitor
has_related_synonym: hexokinase type I inhibitors
has_related_synonym: hexokinase type II inhibitor
has_related_synonym: hexokinase type II inhibitors
has_related_synonym: hexokinase type III inhibitor
has_related_synonym: hexokinase type III inhibitors
has_related_synonym: hexokinase type IV glucokinase inhibitor
has_related_synonym: hexokinase type IV glucokinase inhibitors
has_related_synonym: hexokinase type IV inhibitor
has_related_synonym: hexokinase type IV inhibitors
id: CHEBI:78366
in subset: 3 STAR

EC 3.1.1.5 (lysophospholipase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
textual definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of the enzyme lysophospholipase (EC 3.1.1.5), which catalyses the release of fatty acids from lysophospholipids.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 2-lysophosphatidylcholine acylhydrolase inhibitor
has_related_synonym: 2-lysophosphatidylcholine acylhydrolase inhibitors
has_related_synonym: EC 3.1.1.5 (lysophospholipase) inhibitors
has_related_synonym: EC 3.1.1.5 inhibitor
has_related_synonym: EC 3.1.1.5 inhibitors
has_related_synonym: NTE inhibitor
has_related_synonym: NTE inhibitors
has_related_synonym: NTE-LysoPLA inhibitor
has_related_synonym: NTE-LysoPLA inhibitors
has_related_synonym: NTE-lysophospholipase inhibitor
has_related_synonym: NTE-lysophospholipase inhibitors
has_related_synonym: lecithinase B inhibitor
has_related_synonym: lecithinase B inhibitors
has_related_synonym: lecitholipase inhibitor
has_related_synonym: lecitholipase inhibitors
has_related_synonym: lysolecithinase inhibitor
has_related_synonym: lysolecithinase inhibitors
has_related_synonym: lysophopholipase L2 inhibitor
has_related_synonym: lysophopholipase L2 inhibitors
has_related_synonym: lysophosphatidase inhibitor
has_related_synonym: lysophosphatidase inhibitors
has_related_synonym: lysophosphatidylcholine hydrolase inhibitor
has_related_synonym: lysophosphatidylcholine hydrolase inhibitors
has_related_synonym: lysophospholipase (EC 3.1.1.5) inhibitor
has_related_synonym: lysophospholipase (EC 3.1.1.5) inhibitors
has_related_synonym: lysophospholipase A1 inhibitor
has_related_synonym: lysophospholipase A1 inhibitors
has_related_synonym: lysophospholipase inhibitor
has_related_synonym: lysophospholipase inhibitors
has_related_synonym: lysophospholipase transacylase inhibitor
has_related_synonym: lysophospholipase transacylase inhibitors
has_related_synonym: neuropathy target esterase inhibitor
has_related_synonym: neuropathy target esterase inhibitors
has_related_synonym: phosphatidase B inhibitor
has_related_synonym: phosphatidase B inhibitors
has_related_synonym: phospholipase B inhibitor
has_related_synonym: phospholipase B inhibitors
id: CHEBI:78372
in subset: 3 STAR

EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor
type: Class
subclass of: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of acyl-CoA dehydrogenase (NADP(+)), EC 1.3.1.8.
imported from: chebi.owl
has cross-reference: Wikipedia:Acyl-CoA_dehydrogenase_(NADP%2B)
has_obo_namespace: chebi_ontology
has_related_synonym: 2-enoyl-CoA reductase inhibitor
has_related_synonym: 2-enoyl-CoA reductase inhibitors
has_related_synonym: EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitors
has_related_synonym: EC 1.3.1.8 inhibitor
has_related_synonym: EC 1.3.1.8 inhibitors
has_related_synonym: acyl-CoA dehydrogenase (NADP(+)) (EC 1.3.1.8) inhibitor
has_related_synonym: acyl-CoA dehydrogenase (NADP(+)) (EC 1.3.1.8) inhibitors
has_related_synonym: acyl-CoA dehydrogenase (NADP(+)) inhibitor
has_related_synonym: acyl-CoA dehydrogenase (NADP(+)) inhibitors
has_related_synonym: acyl-CoA:NADP(+) 2-oxidoreductase inhibitor
has_related_synonym: acyl-CoA:NADP(+) 2-oxidoreductase inhibitors
has_related_synonym: crotonyl coenzyme A reductase inhibitor
has_related_synonym: crotonyl coenzyme A reductase inhibitors
has_related_synonym: crotonyl-CoA reductase inhibitor
has_related_synonym: crotonyl-CoA reductase inhibitors
has_related_synonym: dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate) inhibitor
has_related_synonym: dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate) inhibitors
has_related_synonym: enoyl coenzyme A reductase inhibitor
has_related_synonym: enoyl coenzyme A reductase inhibitors
id: CHEBI:78377
in subset: 3 STAR

EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7).
imported from: chebi.owl
has cross-reference: Wikipedia:UDP-N-acetylglucosamine_1-carboxyvinyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitors
has_related_synonym: EC 2.5.1.7 inhibitor
has_related_synonym: EC 2.5.1.7 inhibitors
has_related_synonym: MurA transferase inhibitor
has_related_synonym: MurA transferase inhibitors
has_related_synonym: UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitor
has_related_synonym: UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitors
has_related_synonym: UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitor
has_related_synonym: UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitors
has_related_synonym: UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitor
has_related_synonym: UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitors
has_related_synonym: UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitor
has_related_synonym: UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitors
has_related_synonym: enoylpyruvate transferase inhibitor
has_related_synonym: enoylpyruvate transferase inhibitors
has_related_synonym: phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitor
has_related_synonym: phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitors
has_related_synonym: phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitor
has_related_synonym: phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitors
has_related_synonym: phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitor
has_related_synonym: phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitors
has_related_synonym: phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitor
has_related_synonym: phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitors
has_related_synonym: phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitor
has_related_synonym: phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitors
has_related_synonym: phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitor
has_related_synonym: phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitors
has_related_synonym: phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitor
has_related_synonym: phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitors
has_related_synonym: pyruvate-UDP-acetylglucosamine transferase inhibitor
has_related_synonym: pyruvate-UDP-acetylglucosamine transferase inhibitors
has_related_synonym: pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitor
has_related_synonym: pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitors
has_related_synonym: pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitor
has_related_synonym: pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitors
has_related_synonym: pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitor
has_related_synonym: pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitors
id: CHEBI:78379
in subset: 3 STAR

EC 3.5.4.1 (cytosine deaminase) inhibitor
type: Class
subclass of: EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor
textual definition: An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of cytosine deaminase (EC 3.5.4.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Cytosine_deaminase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.4.1 (cytosine deaminase) inhibitors
has_related_synonym: EC 3.5.4.1 inhibitor
has_related_synonym: EC 3.5.4.1 inhibitors
has_related_synonym: cytosine aminohydrolase inhibitor
has_related_synonym: cytosine aminohydrolase inhibitors
has_related_synonym: cytosine deaminase (EC 3.5.4.1) inhibitor
has_related_synonym: cytosine deaminase (EC 3.5.4.1) inhibitors
has_related_synonym: cytosine deaminase inhibitor
has_related_synonym: cytosine deaminase inhibitors
has_related_synonym: isocytosine deaminase inhibitor
has_related_synonym: isocytosine deaminase inhibitors
id: CHEBI:78380
in subset: 3 STAR

EC 5.1.2.* (racemases acting on hydroxy acids and derivatives) inhibitor
type: Class
subclass of: EC 5.1.* (racemase/epimerase) inhibitor
textual definition: An EC 5.1.* (racemase/epimerase) inhibitor that interferes with the action of any such enzyme acting on hydroxy acids and their derivatives (EC 5.1.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.1.2.* (racemases acting on hydroxy acids and derivatives) inhibitors
has_related_synonym: EC 5.1.2.* inhibitor
has_related_synonym: EC 5.1.2.* inhibitors
has_related_synonym: inhibitor of racemases acting on hydroxy acids and derivatives
has_related_synonym: inhibitor of racemases acting on hydroxy acids and derivatives (EC 5.1.2.*)
has_related_synonym: inhibitors of racemases acting on hydroxy acids and derivatives
has_related_synonym: inhibitors of racemases acting on hydroxy acids and derivatives (EC 5.1.2.*)
id: CHEBI:78381
in subset: 3 STAR

EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor
type: Class
subclass of: EC 5.1.* (racemase/epimerase) inhibitor
textual definition: An EC 5.1.* (racemase/epimerase) inhibitor that interferes with the action of any such enzyme acting on carbohydrates and their derivatives (EC 5.1.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitors
has_related_synonym: EC 5.1.3.* inhibitor
has_related_synonym: EC 5.1.3.* inhibitors
has_related_synonym: inhibitor of racemases acting on carbohydrates and derivatives
has_related_synonym: inhibitor of racemases acting on carbohydrates and derivatives (EC 5.1.3.*)
has_related_synonym: inhibitors of racemases acting on carbohydrates and derivatives
has_related_synonym: inhibitors of racemases acting on carbohydrates and derivatives (EC 5.1.3.*)
id: CHEBI:78382
in subset: 3 STAR

EC 5.1.99.* (racemases acting on other compounds) inhibitor
type: Class
subclass of: EC 5.1.* (racemase/epimerase) inhibitor
textual definition: An EC 5.1.* (racemase/epimerase) inhibitor that interferes with the action of any such enzyme acting compounds other than amino acids and their derivatives, hydroxy acids and their derivatives, or carbohydrates and their derivatives (EC 5.1.99.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.1.99.* (racemases acting on other compounds) inhibitors
has_related_synonym: EC 5.1.99.* inhibitor
has_related_synonym: EC 5.1.99.* inhibitors
has_related_synonym: inhibitor of racemases acting on other compounds (EC 5.1.99.*)
has_related_synonym: inhibitors of racemases acting on other compounds (EC 5.1.99.*)
id: CHEBI:78383
in subset: 3 STAR

EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor
type: Class
subclass of: EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor
textual definition: An EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor that interferes with the action of UDP-glucose 4-epimerase (EC 5.1.3.2).
imported from: chebi.owl
has cross-reference: Wikipedia:UDP-glucose_4-epimerase
has_obo_namespace: chebi_ontology
has_related_synonym: 4-epimerase inhibitor
has_related_synonym: 4-epimerase inhibitors
has_related_synonym: EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitors
has_related_synonym: EC 5.1.3.2 inhibitor
has_related_synonym: EC 5.1.3.2 inhibitors
has_related_synonym: UDP-D-galactose 4-epimerase inhibitor
has_related_synonym: UDP-D-galactose 4-epimerase inhibitors
has_related_synonym: UDP-alpha-D-glucose 4-epimerase inhibitor
has_related_synonym: UDP-alpha-D-glucose 4-epimerase inhibitors
has_related_synonym: UDP-galactose 4-epimerase inhibitor
has_related_synonym: UDP-galactose 4-epimerase inhibitors
has_related_synonym: UDP-glucose 4-epimerase (EC 5.1.3.2) inhibitor
has_related_synonym: UDP-glucose 4-epimerase (EC 5.1.3.2) inhibitors
has_related_synonym: UDP-glucose 4-epimerase inhibitor
has_related_synonym: UDP-glucose 4-epimerase inhibitors
has_related_synonym: UDP-glucose epimerase inhibitor
has_related_synonym: UDP-glucose epimerase inhibitors
has_related_synonym: UDPG-4-epimerase inhibitor
has_related_synonym: UDPG-4-epimerase inhibitors
has_related_synonym: UDPgalactose 4-epimerase inhibitor
has_related_synonym: UDPgalactose 4-epimerase inhibitors
has_related_synonym: UDPglucose 4-epimerase inhibitor
has_related_synonym: UDPglucose 4-epimerase inhibitors
has_related_synonym: galactowaldenase inhibitor
has_related_synonym: galactowaldenase inhibitors
has_related_synonym: uridine diphosphate galactose 4-epimerase inhibitor
has_related_synonym: uridine diphosphate galactose 4-epimerase inhibitors
has_related_synonym: uridine diphosphate glucose 4-epimerase inhibitor
has_related_synonym: uridine diphosphate glucose 4-epimerase inhibitors
has_related_synonym: uridine diphospho-galactose-4-epimerase inhibitor
has_related_synonym: uridine diphospho-galactose-4-epimerase inhibitors
has_related_synonym: uridine diphosphoglucose 4-epimerase inhibitor
has_related_synonym: uridine diphosphoglucose 4-epimerase inhibitors
has_related_synonym: uridine diphosphoglucose epimerase inhibitor
has_related_synonym: uridine diphosphoglucose epimerase inhibitors
id: CHEBI:78384
in subset: 3 STAR

refrigerant
type: Class
subclass of: application
textual definition: A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
imported from: chebi.owl
has cross-reference: Wikipedia:Refrigerant
has_obo_namespace: chebi_ontology
has_related_synonym: refrigerants
id: CHEBI:78433
in subset: 3 STAR

EC 3.1.1.1 (carboxylesterase) inhibitor
type: Class
subclass of: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
textual definition: Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 ).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Alpha-carboxylesterase inhibitor
has_related_synonym: Alpha-carboxylesterase inhibitors
has_related_synonym: Beta-esterase inhibitor
has_related_synonym: Beta-esterase inhibitors
has_related_synonym: EC 3.1.1.1 (carboxylesterase) inhibitors
has_related_synonym: ali-esterase inhibitor
has_related_synonym: ali-esterase inhibitors
has_related_synonym: butyrate esterase inhibitor
has_related_synonym: butyrate esterase inhibitors
has_related_synonym: butyryl esterase inhibitor
has_related_synonym: butyryl esterase inhibitors
has_related_synonym: carboxyl ester hydrolase inhibitor
has_related_synonym: carboxyl ester hydrolase inhibitors
has_related_synonym: carboxylate esterase inhibitor
has_related_synonym: carboxylate esterase inhibitors
has_related_synonym: carboxylesterase inhibitor
has_related_synonym: carboxylesterase inhibitors
has_related_synonym: carboxylic acid esterase inhibitor
has_related_synonym: carboxylic acid esterase inhibitors
has_related_synonym: carboxylic esterase inhibitor
has_related_synonym: carboxylic esterase inhibitors
has_related_synonym: carboxylic-ester hydrolase inhibitor
has_related_synonym: carboxylic-ester hydrolase inhibitors
has_related_synonym: cocaine esterase inhibitor
has_related_synonym: cocaine esterase inhibitors
has_related_synonym: esterase A inhibitor
has_related_synonym: esterase A inhibitors
has_related_synonym: esterase B inhibitor
has_related_synonym: esterase B inhibitors
has_related_synonym: esterase D inhibitor
has_related_synonym: esterase D inhibitors
has_related_synonym: methylbutyrase inhibitor
has_related_synonym: methylbutyrase inhibitors
has_related_synonym: methylbutyrate esterase inhibitor
has_related_synonym: methylbutyrate esterase inhibitors
has_related_synonym: monobutyrase inhibitor
has_related_synonym: monobutyrase inhibitors
has_related_synonym: nonspecific carboxylesterase inhibitor
has_related_synonym: nonspecific carboxylesterase inhibitors
has_related_synonym: procaine esterase inhibitor
has_related_synonym: procaine esterase inhibitors
has_related_synonym: propionyl esterase inhibitor
has_related_synonym: propionyl esterase inhibitors
has_related_synonym: serine esterase inhibitor
has_related_synonym: serine esterase inhibitors
has_related_synonym: triacetin esterase inhibitor
has_related_synonym: triacetin esterase inhibitors
has_related_synonym: vitamin A esterase inhibitor
has_related_synonym: vitamin A esterase inhibitors
id: CHEBI:78444
in subset: 3 STAR

venom
type: Class
subclass of: toxin
textual definition: A toxin used by animals and injected into their victims by a bite or sting.
imported from: chebi.owl
has cross-reference: Wikipedia:Venom
has_obo_namespace: chebi_ontology
has_related_synonym: venoms
id: CHEBI:78505
in subset: 3 STAR

protein kinase A agonist
type: Class
subclass of: protein kinase agonist
textual definition: A protein kinase agonist that selectively binds to and activates a protein kinase A receptor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: protein kinase A agonists
id: CHEBI:78547
in subset: 3 STAR

adenylate cyclase agonist
type: Class
subclass of: agonist
textual definition: Any agonist of one or more of the isoforms of adenylate cyclase (EC 4.6.1.1).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adenylate cyclase agonists
has_related_synonym: adenylyl cyclase agonist
has_related_synonym: adenylyl cyclase agonists
id: CHEBI:78548
in subset: 3 STAR

vesicant
type: Class
subclass of: biophysical role
textual definition: Any compound that causes severe skin, eye and mucosal pain and irritation.
imported from: chebi.owl
has cross-reference: PMID:16168310
has cross-reference: Wikipedia:Blister_agent
has_obo_namespace: chebi_ontology
has_related_synonym: blister agent
has_related_synonym: blister agents
has_related_synonym: vesicants
id: CHEBI:78592
in subset: 3 STAR

Hsp70 inducer
type: Class
subclass of: activator
textual definition: Any inducer of heat shock protein 70.
imported from: chebi.owl
has cross-reference: Wikipedia:Hsp70
has_obo_namespace: chebi_ontology
has_related_synonym: Hsp70 activator
has_related_synonym: Hsp70 activators
has_related_synonym: Hsp70 inducers
has_related_synonym: heat shock protein 70 activator
has_related_synonym: heat shock protein 70 activators
has_related_synonym: heat shock protein 70 inducer
has_related_synonym: heat shock protein 70 inducers
id: CHEBI:78606
in subset: 3 STAR

EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of any [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.11.31).
imported from: chebi.owl
has cross-reference: Wikipedia:AMP-activated_protein_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase inhibitor
has_related_synonym: 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase inhibitors
has_related_synonym: 3-hydroxy-3-methylglutaryl-CoA reductase kinase inhibitor
has_related_synonym: 3-hydroxy-3-methylglutaryl-CoA reductase kinase inhibitors
has_related_synonym: AMP-activated protein kinase inhibitor
has_related_synonym: AMP-activated protein kinase inhibitors
has_related_synonym: AMPK inhibitor
has_related_synonym: AMPK inhibitors
has_related_synonym: ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase inhibitor
has_related_synonym: ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase inhibitors
has_related_synonym: EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) inhibitor
has_related_synonym: EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) inhibitors
has_related_synonym: EC 2.7.11.31 inhibitor
has_related_synonym: EC 2.7.11.31 inhibitors
has_related_synonym: EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitors
has_related_synonym: HMG-CoA reductase kinase inhibitor
has_related_synonym: HMG-CoA reductase kinase inhibitors
has_related_synonym: STK29 inhibitor
has_related_synonym: STK29 inhibitors
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase inhibitor
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase inhibitors
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase inhibitor
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase inhibitors
has_related_synonym: beta-hydroxy-beta-methylglutaryl-CoA reductase kinase inhibitor
has_related_synonym: beta-hydroxy-beta-methylglutaryl-CoA reductase kinase inhibitors
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) inhibitor
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) inhibitors
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase inhibitor
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase inhibitors
has_related_synonym: hydroxymethylglutaryl-CoA reductase kinase inhibitor
has_related_synonym: hydroxymethylglutaryl-CoA reductase kinase inhibitors
has_related_synonym: reductase kinase inhibitor
has_related_synonym: reductase kinase inhibitors
id: CHEBI:78622
in subset: 3 STAR

bone morphogenetic protein receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at the bone morphogenetic protein receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: BMP antagonist
has_related_synonym: BMP antagonists
has_related_synonym: BMP receptor inhibitor
has_related_synonym: BMP receptor inhibitors
has_related_synonym: bone morphogenetic protein antagonists
has_related_synonym: bone morphogenetic protein inhibitor
has_related_synonym: bone morphogenetic protein receptor inhibitors
id: CHEBI:78623
in subset: 3 STAR

fundamental metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite produced by all living cells.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: essential metabolite
has_related_synonym: essential metabolites
has_related_synonym: fundamental metabolites
id: CHEBI:78675
in subset: 3 STAR

EC 4.6.1.2 (guanylate cyclase) inhibitor
type: Class
subclass of: EC 4.6.* (P-O lyase) inhibitor
textual definition: An EC 4.6.* (P-O lyase) inhibitor that interferes with the action of enzyme guanylate cyclase (EC 4.6.1.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Guanylate_cyclase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.6.1.2 (guanylate cyclase) inhibitors
has_related_synonym: EC 4.6.1.2 inhibitor
has_related_synonym: EC 4.6.1.2 inhibitors
has_related_synonym: GTP diphosphate-lyase (cyclizing) inhibitor
has_related_synonym: GTP diphosphate-lyase (cyclizing) inhibitors
has_related_synonym: GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitor
has_related_synonym: GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitors
has_related_synonym: guanyl cyclase inhibitor
has_related_synonym: guanyl cyclase inhibitors
has_related_synonym: guanylyl cyclase inhibitor
has_related_synonym: guanylyl cyclase inhibitors
id: CHEBI:78678
in subset: 3 STAR

tropomyosin-related kinase B receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates the tropomyosin-related kinase B (TrkB) receptor, the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: TrkB receptor antagonist
has_related_synonym: TrkB receptor antagonists
has_related_synonym: tropomyosin-related kinase B receptor antagonists
id: CHEBI:78681
in subset: 3 STAR

EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitors
has_related_synonym: myristoyl-CoA-protein N-myristoyltransferase inhibitor
has_related_synonym: myristoyl-CoA-protein N-myristoyltransferase inhibitors
has_related_synonym: myristoyl-coenzyme A:protein N-myristoyl transferase inhibitor
has_related_synonym: myristoyl-coenzyme A:protein N-myristoyl transferase inhibitors
has_related_synonym: peptide N-myristoyltransferase inhibitor
has_related_synonym: peptide N-myristoyltransferase inhibitors
has_related_synonym: protein N-myristoyltransferase inhibitor
has_related_synonym: protein N-myristoyltransferase inhibitors
has_related_synonym: tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase inhibitor
has_related_synonym: tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase inhibitors
id: CHEBI:78691
in subset: 3 STAR

EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor
type: Class
subclass of: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of Delta(24)-sterol reductase (EC 1.3.1.72).
imported from: chebi.owl
has cross-reference: Wikipedia:Delta24-sterol_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: Delta(24)-sterol reductase (EC 1.3.1.72) inhibitor
has_related_synonym: Delta(24)-sterol reductase (EC 1.3.1.72) inhibitors
has_related_synonym: Delta(24)-sterol reductase inhibitor
has_related_synonym: Delta(24)-sterol reductase inhibitors
has_related_synonym: EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitors
has_related_synonym: EC 1.3.1.72 inhibitor
has_related_synonym: EC 1.3.1.72 inhibitors
has_related_synonym: lanosterol Delta (24)-reductase
has_related_synonym: sterol:NADP(+) Delta(24)-oxidoreductase
id: CHEBI:78728
in subset: 3 STAR

EC 2.5.1.6 (methionine adenosyltransferase) inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of methionine adenosyltransferase (EC 2.5.1.6).
imported from: chebi.owl
has cross-reference: Wikipedia:S-adenosylmethionine_synthetase_enzyme
has_obo_namespace: chebi_ontology
has_related_synonym: ATP-methionine adenosyltransferase inhibitor
has_related_synonym: ATP-methionine adenosyltransferase inhibitors
has_related_synonym: ATP:L-methionine S-adenosyltransferase inhibitor
has_related_synonym: ATP:L-methionine S-adenosyltransferase inhibitors
has_related_synonym: AdoMet synthetase inhibitor
has_related_synonym: AdoMet synthetase inhibitors
has_related_synonym: EC 2.5.1.6 (methionine adenosyltransferase) inhibitors
has_related_synonym: EC 2.5.1.6 inhibitor
has_related_synonym: EC 2.5.1.6 inhibitors
has_related_synonym: S-adenosyl-L-methionine synthetase inhibitor
has_related_synonym: S-adenosyl-L-methionine synthetase inhibitors
has_related_synonym: S-adenosylmethionine synthase inhibitor
has_related_synonym: S-adenosylmethionine synthase inhibitors
has_related_synonym: S-adenosylmethionine synthetase inhibitor
has_related_synonym: S-adenosylmethionine synthetase inhibitors
has_related_synonym: adenosylmethionine synthetase inhibitor
has_related_synonym: adenosylmethionine synthetase inhibitors
has_related_synonym: methionine S-adenosyltransferase inhibitor
has_related_synonym: methionine S-adenosyltransferase inhibitors
has_related_synonym: methionine-activating enzyme inhibitor
has_related_synonym: methionine-activating enzyme inhibitors
id: CHEBI:78756
in subset: 3 STAR

EC 2.7.1.91 (sphingosine kinase) inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of sphinganine kinase (EC 2.7.1.91).
imported from: chebi.owl
has cross-reference: Wikipedia:Sphingosine_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:sphinganine 1-phosphotransferase inhibitor
has_related_synonym: ATP:sphinganine 1-phosphotransferase inhibitors
has_related_synonym: EC 2.7.1.91 (sphinganine kinase) inhibitor
has_related_synonym: EC 2.7.1.91 (sphinganine kinase) inhibitors
has_related_synonym: EC 2.7.1.91 (sphingosine kinase) inhibitors
has_related_synonym: EC 2.7.1.91 inhibitor
has_related_synonym: EC 2.7.1.91 inhibitors
has_related_synonym: SGK inhibitor
has_related_synonym: SGK inhibitors
has_related_synonym: SK inhibitor
has_related_synonym: SK inhibitors
has_related_synonym: dihydrosphingosine kinase (phosphorylating) inhibitor
has_related_synonym: dihydrosphingosine kinase (phosphorylating) inhibitors
has_related_synonym: dihydrosphingosine kinase inhibitor
has_related_synonym: dihydrosphingosine kinase inhibitors
has_related_synonym: sphinganine kinase inhibitor
has_related_synonym: sphinganine kinase inhibitors
has_related_synonym: sphingoid base kinase inhibitor
has_related_synonym: sphingoid base kinase inhibitors
has_related_synonym: sphingosine kinase (phosphorylating) inhibitor
has_related_synonym: sphingosine kinase (phosphorylating) inhibitors
id: CHEBI:78760
in subset: 3 STAR

EC 2.7.11.18 (myosin-light-chain kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of myosin-light-chain kinase (EC 2.7.11.18).
imported from: chebi.owl
has cross-reference: Wikipedia:Myosin_light-chain_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:[myosin-light-chain] O-phosphotransferase inhibitor
has_related_synonym: ATP:[myosin-light-chain] O-phosphotransferase inhibitors
has_related_synonym: ATP:myosin-light-chain O-phosphotransferase inhibitor
has_related_synonym: ATP:myosin-light-chain O-phosphotransferase inhibitors
has_related_synonym: EC 2.7.11.18 (myosin-light-chain kinase) inhibitors
has_related_synonym: EC 2.7.11.18 inhibitor
has_related_synonym: EC 2.7.11.18 inhibitors
has_related_synonym: MLCK inhibitor
has_related_synonym: MLCK inhibitors
has_related_synonym: MLCkase inhibitor
has_related_synonym: MLCkase inhibitors
has_related_synonym: [myosin-light-chain] kinase inhibitor
has_related_synonym: [myosin-light-chain] kinase inhibitors
has_related_synonym: calcium/calmodulin-dependent myosin light chain kinase inhibitor
has_related_synonym: calcium/calmodulin-dependent myosin light chain kinase inhibitors
has_related_synonym: myosin kinase inhibitor
has_related_synonym: myosin kinase inhibitors
has_related_synonym: myosin light chain kinase inhibitor
has_related_synonym: myosin light chain kinase inhibitors
has_related_synonym: myosin light chain protein kinase inhibitor
has_related_synonym: myosin light chain protein kinase inhibitors
has_related_synonym: myosin light-chain kinase (phosphorylating) inhibitor
has_related_synonym: myosin light-chain kinase (phosphorylating) inhibitors
has_related_synonym: myosin light-chain kinase inhibitor
has_related_synonym: myosin light-chain kinase inhibitors
has_related_synonym: myosin-light-chain kinase (EC 2.7.11.18) inhibitor
has_related_synonym: myosin-light-chain kinase (EC 2.7.11.18) inhibitors
has_related_synonym: myosin-light-chain kinase inhibitor
has_related_synonym: myosin-light-chain kinase inhibitors
has_related_synonym: smooth-muscle-myosin-light-chain kinase inhibitor
has_related_synonym: smooth-muscle-myosin-light-chain kinase inhibitors
id: CHEBI:78763
in subset: 3 STAR

nematode metabolite
type: Class
subclass of: animal metabolite
textual definition: An animal metabolite produced by any member of the phylum Nematoda.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nematode metabolites
id: CHEBI:78803
in subset: 3 STAR

Caenorhabditis elegans metabolite
type: Class
subclass of: nematode metabolite
textual definition: A nematode metabolite produced by Caenorhabditis elegans.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: C. elegans metabolite
has_related_synonym: C. elegans metabolites
has_related_synonym: Caenorhabditis elegans metabolites
id: CHEBI:78804
in subset: 3 STAR

survivin dimerisation modulator
type: Class
subclass of: pharmacological role
textual definition: Any compound that affects the dimerisation of the protein survivin.
imported from: chebi.owl
has cross-reference: PMID:23968825
has cross-reference: PMID:26924735
has cross-reference: Patent:FR2955113
has_obo_namespace: chebi_ontology
has_related_synonym: survivin dimerisation modulators
has_related_synonym: survivin modulator
has_related_synonym: survivin modulators
id: CHEBI:78926
in subset: 3 STAR

EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitor
type: Class
subclass of: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
textual definition: Any EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme acting on phosphorus-containing anhydrides.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitors
has_related_synonym: EC 3.6.1.* (hydrolases acting on acid anhydrides in phosphorus-containing anhydrides) inhibitor
has_related_synonym: EC 3.6.1.* (hydrolases acting on acid anhydrides in phosphorus-containing anhydrides) inhibitors
has_related_synonym: EC 3.6.1.* inhibitor
has_related_synonym: EC 3.6.1.* inhibitors
has_related_synonym: hydrolases acting on acid anhydrides in P-containing anhydrides (EC 3.6.1.*) inhibitor
has_related_synonym: hydrolases acting on acid anhydrides in P-containing anhydrides (EC 3.6.1.*) inhibitors
has_related_synonym: hydrolases acting on acid anhydrides in phosphorus-containing anhydrides (EC 3.6.1.*) inhibitor
has_related_synonym: hydrolases acting on acid anhydrides in phosphorus-containing anhydrides (EC 3.6.1.*) inhibitors
id: CHEBI:78927
in subset: 3 STAR

EC 3.6.1.3 (adenosinetriphosphatase) inhibitor
type: Class
subclass of: EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitor
textual definition: An EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitor that interferes with the action of adenosinetriphosphatase (EC 3.6.1.3).
imported from: chebi.owl
has cross-reference: Wikipedia:ATPase
has_obo_namespace: chebi_ontology
has_related_synonym: (Ca(2+) + Mg(2+))-ATPase inhibitor
has_related_synonym: (Ca(2+) + Mg(2+))-ATPase inhibitors
has_related_synonym: ATP hydrolase inhibitor
has_related_synonym: ATP hydrolase inhibitors
has_related_synonym: ATP monophosphatase inhibitor
has_related_synonym: ATP monophosphatase inhibitors
has_related_synonym: ATP phosphohydrolase inhibitor
has_related_synonym: ATP phosphohydrolase inhibitors
has_related_synonym: ATPase inhibitor
has_related_synonym: ATPase inhibitors
has_related_synonym: EC 3.6.1.3 (adenosinetriphosphatase) inhibitors
has_related_synonym: EC 3.6.1.3 inhibitor
has_related_synonym: EC 3.6.1.3 inhibitors
has_related_synonym: HCO3(-)-ATPase inhibitor
has_related_synonym: HCO3(-)-ATPase inhibitors
has_related_synonym: SV40 T-antigen inhibitor
has_related_synonym: SV40 T-antigen inhibitors
has_related_synonym: adenosine 5'-triphosphatase inhibitor
has_related_synonym: adenosine 5'-triphosphatase inhibitors
has_related_synonym: adenosine triphosphatase inhibitor
has_related_synonym: adenosine triphosphatase inhibitors
has_related_synonym: adenosinetriphosphatase (EC 3.6.1.3) inhibitor
has_related_synonym: adenosinetriphosphatase (EC 3.6.1.3) inhibitors
has_related_synonym: adenosinetriphosphatase inhibitor
has_related_synonym: adenosinetriphosphatase inhibitors
has_related_synonym: adenylpyrophosphatase inhibitor
has_related_synonym: adenylpyrophosphatase inhibitors
has_related_synonym: complex V (mitochondrial electron transport) inhibitor
has_related_synonym: complex V (mitochondrial electron transport) inhibitors
has_related_synonym: triphosphatase inhibitor
has_related_synonym: triphosphatase inhibitors
id: CHEBI:78928
in subset: 3 STAR

archaeal metabolite
type: Class
subclass of: prokaryotic metabolite
textual definition: Any prokaryotic metabolite produced during a metabolic reaction in single-celled microorganisms, archaea.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: archaeal metabolites
id: CHEBI:78947
in subset: 3 STAR

melatonin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates melatonin receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Melatonin_receptor_agonist
has_obo_namespace: chebi_ontology
has_related_synonym: melatonin receptor agonists
id: CHEBI:79046
in subset: 3 STAR

EC 3.4.22.52 (calpain-1) inhibitor
type: Class
subclass of: calpain inhibitor
textual definition: A calpain inhibitor that interferes with the action of calpain-1 (EC 3.4.22.52).
imported from: chebi.owl
has cross-reference: Wikipedia:Calpain-1
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.22.52 (calpain-1) inhibitors
has_related_synonym: EC 3.4.22.52 inhibitor
has_related_synonym: EC 3.4.22.52 inhibitors
has_related_synonym: calcium-activated neutral protease I inhibitor
has_related_synonym: calcium-activated neutral protease I inhibitors
has_related_synonym: calpain-1 (EC 3.4.22.52) inhibitor
has_related_synonym: calpain-1 (EC 3.4.22.52) inhibitors
has_related_synonym: calpain-1 inhibitor
has_related_synonym: calpain-1 inhibitors
has_related_synonym: mu-calpain inhibitor
has_related_synonym: mu-calpain inhibitors
id: CHEBI:79050
in subset: 3 STAR

plasticiser
type: Class
subclass of: application
textual definition: Any compound that is used as an additive to increase the plasticity or fluidity of a substance, particularly but not exclusively to synthetic polymers.
imported from: chebi.owl
has cross-reference: Wikipedia:Plasticizer
has_obo_namespace: chebi_ontology
has_related_synonym: plasticisers
has_related_synonym: plasticizer
has_related_synonym: plasticizers
id: CHEBI:79056
in subset: 3 STAR

potassium channel opener
type: Class
subclass of: potassium channel modulator
textual definition: A potassium channel modulator that opens the potassium channel.
imported from: chebi.owl
has cross-reference: Wikipedia:Potassium_channel_opener
has_obo_namespace: chebi_ontology
has_related_synonym: potassium channel activator
has_related_synonym: potassium channel activators
has_related_synonym: potassium channel agonist
has_related_synonym: potassium channel agonists
has_related_synonym: potassium channel openers
id: CHEBI:79085
in subset: 3 STAR

EC 3.4.24.35 (gelatinase B) inhibitor
type: Class
subclass of: matrix metalloproteinase inhibitor
subclass of: EC 3.4.24.* (metalloendopeptidase) inhibitor
textual definition: An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of gelatinase B (EC 3.4.24.35).
imported from: chebi.owl
has cross-reference: Wikipedia:Gelatinase_B
has_obo_namespace: chebi_ontology
has_related_synonym: 92-kDa gelatinase inhibitor
has_related_synonym: 92-kDa gelatinase inhibitors
has_related_synonym: 92-kDa type IV collagenase inhibitor
has_related_synonym: 92-kDa type IV collagenase inhibitors
has_related_synonym: 95 kDa type IV collagenase/gelatinase inhibitor
has_related_synonym: 95 kDa type IV collagenase/gelatinase inhibitors
has_related_synonym: EC 3.4.24.35 (gelatinase B) inhibitors
has_related_synonym: EC 3.4.24.35 inhibitor
has_related_synonym: EC 3.4.24.35 inhibitors
has_related_synonym: MMP 9 inhibitor
has_related_synonym: MMP 9 inhibitors
has_related_synonym: collagenase IV inhibitor
has_related_synonym: collagenase IV inhibitors
has_related_synonym: collagenase type IV inhibitor
has_related_synonym: collagenase type IV inhibitors
has_related_synonym: gelatinase B (EC 3.4.24.35) inhibitor
has_related_synonym: gelatinase B (EC 3.4.24.35) inhibitors
has_related_synonym: gelatinase B inhibitor
has_related_synonym: gelatinase B inhibitors
has_related_synonym: gelatinase MMP 9 inhibitor
has_related_synonym: gelatinase MMP 9 inhibitors
has_related_synonym: macrophage gelatinase inhibitor
has_related_synonym: macrophage gelatinase inhibitors
has_related_synonym: matrix metalloproteinase 9 inhibitor
has_related_synonym: matrix metalloproteinase 9 inhibitors
has_related_synonym: type IV collagen metalloproteinase inhibitor
has_related_synonym: type IV collagen metalloproteinase inhibitors
has_related_synonym: type V collagenase inhibitor
has_related_synonym: type V collagenase inhibitors
id: CHEBI:79088
in subset: 3 STAR

EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
type: Class
subclass of: protein kinase inhibitor
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
imported from: chebi.owl
has_alternative_id: CHEBI:75997
has cross-reference: Wikipedia:MEK_inhibitor
has cross-reference: Wikipedia:Mitogen-activated_protein_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:protein phosphotransferase (MAPKK-activated) inhibitor
has_related_synonym: ATP:protein phosphotransferase (MAPKK-activated) inhibitors
has_related_synonym: Dp38 inhibitor
has_related_synonym: Dp38 inhibitors
has_related_synonym: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors
has_related_synonym: EC 2.7.11.24 inhibitor
has_related_synonym: EC 2.7.11.24 inhibitors
has_related_synonym: ERK inhibitor
has_related_synonym: ERK inhibitors
has_related_synonym: ERK1 inhibitor
has_related_synonym: ERK1 inhibitors
has_related_synonym: ERK2 inhibitor
has_related_synonym: ERK2 inhibitors
has_related_synonym: JNK inhibitor
has_related_synonym: JNK inhibitors
has_related_synonym: JNK3alpha1 inhibitor
has_related_synonym: JNK3alpha1 inhibitors
has_related_synonym: LeMPK3 inhibitor
has_related_synonym: LeMPK3 inhibitors
has_related_synonym: MAP kinase inhibitor
has_related_synonym: MAP kinase inhibitors
has_related_synonym: MAP-2 kinase inhibitor
has_related_synonym: MAP-2 kinase inhibitors
has_related_synonym: MAPK inhibitor
has_related_synonym: MAPK inhibitors
has_related_synonym: MBP kinase I inhibitor
has_related_synonym: MBP kinase I inhibitors
has_related_synonym: MBP kinase II inhibitor
has_related_synonym: MBP kinase II inhibitors
has_related_synonym: MEK inhibitor
has_related_synonym: MEK inhibitors
has_related_synonym: PMK-1 inhibitor
has_related_synonym: PMK-1 inhibitors
has_related_synonym: PMK-2 inhibitor
has_related_synonym: PMK-2 inhibitors
has_related_synonym: PMK-3 inhibitor
has_related_synonym: PMK-3 inhibitors
has_related_synonym: SAPK inhibitor
has_related_synonym: SAPK inhibitors
has_related_synonym: STK26 inhibitor
has_related_synonym: STK26 inhibitors
has_related_synonym: c-Jun N-terminal kinase inhibitor
has_related_synonym: c-Jun N-terminal kinase inhibitors
has_related_synonym: extracellular signal-regulated kinase inhibitor
has_related_synonym: extracellular signal-regulated kinase inhibitors
has_related_synonym: microtubule-associated protein 2 kinase inhibitor
has_related_synonym: microtubule-associated protein 2 kinase inhibitors
has_related_synonym: microtubule-associated protein kinase inhibitor
has_related_synonym: microtubule-associated protein kinase inhibitors
has_related_synonym: mitogen-activated protein kinase (EC 2.7.11.24) inhibitor
has_related_synonym: mitogen-activated protein kinase (EC 2.7.11.24) inhibitors
has_related_synonym: mitogen-activated protein kinase inhibitor
has_related_synonym: mitogen-activated protein kinase inhibitors
has_related_synonym: myelin basic protein kinase inhibitor
has_related_synonym: myelin basic protein kinase inhibitors
has_related_synonym: p38-2 inhibitor
has_related_synonym: p38-2 inhibitors
has_related_synonym: p38delta inhibitor
has_related_synonym: p38delta inhibitors
has_related_synonym: p42 mitogen-activated protein kinase inhibitor
has_related_synonym: p42 mitogen-activated protein kinase inhibitors
has_related_synonym: p42(mapk) inhibitor
has_related_synonym: p42(mapk) inhibitors
has_related_synonym: p44mpk inhibitor
has_related_synonym: p44mpk inhibitors
has_related_synonym: pp42 inhibitor
has_related_synonym: pp42 inhibitors
has_related_synonym: pp44(mapk) inhibitor
has_related_synonym: pp44(mapk) inhibitors
has_related_synonym: stress-activated protein kinase inhibitor
has_related_synonym: stress-activated protein kinase inhibitors

EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor
type: Class
subclass of: EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor
textual definition: An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any such enzyme using H2O2 as acceptor and incorporating one oxygen atom of the H2O2 into the product (EC 1.11.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitors
has_related_synonym: EC 1.11.2.* inhibitor
has_related_synonym: EC 1.11.2.* inhibitors
id: CHEBI:79092
in subset: 3 STAR

EC 1.11.2.2 (myeloperoxidase) inhibitor
type: Class
subclass of: EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor
textual definition: An EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor that interferes with the action of myeloperoxidase (EC 1.11.2.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Myeloperoxidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.11.2.2 (myeloperoxidase) inhibitors
has_related_synonym: EC 1.11.2.2 inhibitor
has_related_synonym: EC 1.11.2.2 inhibitors
has_related_synonym: MPO inhibitor
has_related_synonym: MPO inhibitors
has_related_synonym: chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitor
has_related_synonym: chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitors
has_related_synonym: myeloperoxidase (EC 1.11.2.2) inhibitor
has_related_synonym: myeloperoxidase (EC 1.11.2.2) inhibitors
has_related_synonym: myeloperoxidase inhibitor
has_related_synonym: myeloperoxidase inhibitors
has_related_synonym: verdoperoxidase inhibitor
has_related_synonym: verdoperoxidase inhibitors
id: CHEBI:79093
in subset: 3 STAR

flame retardant
type: Class
subclass of: application
textual definition: Any compound that is added to manufactured materials to inhibit, suppress, or delay the production of flames and so prevent the spread of fire.
imported from: chebi.owl
has cross-reference: Wikipedia:Flame_retardant
has_obo_namespace: chebi_ontology
has_related_synonym: flame retardants
id: CHEBI:79314
in subset: 3 STAR

paroxetine
type: Class
subclass of: molecular entity
textual definition: A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
imported from: chebi.owl
charge: 0
formula: C19H20FNO3
inchi: InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
inchikey: AHOUBRCZNHFOSL-YOEHRIQHSA-N
mass: 329.36540
monoisotopicmass: 329.14272
has cross-reference: CAS:61869-08-7
has cross-reference: DrugBank:DB00715
has cross-reference: Drug_Central:2068
has cross-reference: KEGG:C07415
has cross-reference: KEGG:D02362
has cross-reference: LINCS:LSM-2843
has cross-reference: PMID:11009210
has cross-reference: PMID:11169163
has cross-reference: PMID:11271409
has cross-reference: PMID:11281965
has cross-reference: PMID:11324355
has cross-reference: PMID:11360029
has cross-reference: PMID:11513198
has cross-reference: PMID:11563413
has cross-reference: PMID:11565622
has cross-reference: PMID:11819027
has cross-reference: PMID:11893234
has cross-reference: PMID:11910269
has cross-reference: PMID:12027788
has cross-reference: PMID:12088162
has cross-reference: PMID:12369443
has cross-reference: PMID:12421645
has cross-reference: PMID:12818234
has cross-reference: PMID:12820211
has cross-reference: PMID:12906023
has cross-reference: PMID:12920419
has cross-reference: PMID:14516531
has cross-reference: PMID:14521492
has cross-reference: PMID:14566196
has cross-reference: PMID:14566200
has cross-reference: PMID:14619895
has cross-reference: PMID:14624192
has cross-reference: PMID:14673053
has cross-reference: PMID:14689334
has cross-reference: PMID:14978354
has cross-reference: PMID:15048901
has cross-reference: PMID:15199661
has cross-reference: PMID:15241233
has cross-reference: PMID:15264994
has cross-reference: PMID:15374134
has cross-reference: PMID:15376524
has cross-reference: PMID:15544025
has cross-reference: PMID:15613191
has cross-reference: PMID:15845695
has cross-reference: PMID:15853570
has cross-reference: PMID:15903129
has cross-reference: PMID:15963219
has cross-reference: PMID:15992089
has cross-reference: PMID:16395417
has cross-reference: PMID:16397315
has cross-reference: PMID:16426087
has cross-reference: PMID:16765127
has cross-reference: PMID:16822276
has cross-reference: PMID:16913391
has cross-reference: PMID:17122538
has cross-reference: PMID:17162096
has cross-reference: PMID:17219219
has cross-reference: PMID:17286545
has cross-reference: PMID:17452166
has cross-reference: PMID:17559097
has cross-reference: PMID:17612590
has cross-reference: PMID:17652957
has cross-reference: PMID:17874333
has cross-reference: PMID:18273418
has cross-reference: PMID:18345955
has cross-reference: PMID:18808757
has cross-reference: PMID:18983224
has cross-reference: PMID:19687003
has cross-reference: PMID:19851065
has cross-reference: PMID:21404089

glycerophosphoinositol synthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: A pathway inhibitor that disrupts the synthesis of glycerophosphoinositol
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GPI synthesis inhibitor
has_related_synonym: GPI synthesis inhibitors
has_related_synonym: glycerophosphoinositol synthesis inhibitors
id: CHEBI:79386
in subset: 3 STAR

EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitor
type: Class
subclass of: EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor
textual definition: An EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor that interferes with the action of any tryptophan--tRNA ligase (EC 6.1.1.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Tryptophan-tRNA_ligase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitors
has_related_synonym: EC 6.1.1.2 inhibitor
has_related_synonym: EC 6.1.1.2 inhibitors
has_related_synonym: L-tryptophan-tRNA(Trp) ligase (AMP-forming) inhibitor
has_related_synonym: L-tryptophan-tRNA(Trp) ligase (AMP-forming) inhibitors
has_related_synonym: L-tryptophan:tRNA(Trp) ligase (AMP-forming) inhibitor
has_related_synonym: L-tryptophan:tRNA(Trp) ligase (AMP-forming) inhibitors
has_related_synonym: TrpRS inhibitor
has_related_synonym: TrpRS inhibitors
has_related_synonym: tryptophan translase inhibitor
has_related_synonym: tryptophan translase inhibitors
has_related_synonym: tryptophan--tRNA ligase (EC 6.1.1.2) inhibitor
has_related_synonym: tryptophan--tRNA ligase (EC 6.1.1.2) inhibitors
has_related_synonym: tryptophanyl ribonucleic synthetase inhibitor
has_related_synonym: tryptophanyl ribonucleic synthetase inhibitors
has_related_synonym: tryptophanyl-tRNA synthase inhibitor
has_related_synonym: tryptophanyl-tRNA synthase inhibitors
has_related_synonym: tryptophanyl-tRNA synthetase inhibitor
has_related_synonym: tryptophanyl-tRNA synthetase inhibitors
has_related_synonym: tryptophanyl-transfer RNA synthetase inhibitor
has_related_synonym: tryptophanyl-transfer RNA synthetase inhibitors
has_related_synonym: tryptophanyl-transfer ribonucleate synthetase inhibitor
has_related_synonym: tryptophanyl-transfer ribonucleate synthetase inhibitors
has_related_synonym: tryptophanyl-transfer ribonucleic acid synthetase inhibitor
has_related_synonym: tryptophanyl-transfer ribonucleic acid synthetase inhibitors
has_related_synonym: tryptophanyl-transfer ribonucleic synthetase inhibitor
has_related_synonym: tryptophanyl-transfer ribonucleic synthetase inhibitors
id: CHEBI:79392
in subset: 3 STAR

phenacetin
type: Class
subclass of: molecular entity
textual definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.
imported from: chebi.owl
charge: 0
formula: C10H13NO2
inchi: InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
inchikey: CPJSUEIXXCENMM-UHFFFAOYSA-N
mass: 179.216
monoisotopicmass: 179.09463
smiles: C=1C=C(OCC)C=CC1NC(C)=O
has cross-reference: CAS:62-44-2
has cross-reference: DrugBank:DB03783
has cross-reference: Drug_Central:2115
has cross-reference: KEGG:C07591
has cross-reference: KEGG:D00569
has cross-reference: LINCS:LSM-2851
has cross-reference: PDBeChem:N4E
has cross-reference: PMID:24201458
has cross-reference: PMID:24447449
has cross-reference: Patent:US2887513
has cross-reference: Reaxys:1869238
has cross-reference: Wikipedia:Phenacetin
alternative_term: N-(4-ethoxyphenyl)acetamide
alternative_term: Phenacetin
has_obo_namespace: chebi_ontology
has_related_synonym: 1-Acetamido-4-ethoxybenzene
has_related_synonym: 4-Ethoxyacetanilide
has_related_synonym: Acetophenetidin
has_related_synonym: Acetophenetidine
has_related_synonym: Acetophenetin
has_related_synonym: Acetphenetidin
has_related_synonym: Achrocidin
has_related_synonym: Codempiral
has_related_synonym: Commotional
has_related_synonym: Contradol
has_related_synonym: Contradouleur
has_related_synonym: Fenacetina
has_related_synonym: N-(4-ethoxyphenyl)acetamide
has_related_synonym: Phenacetine
has_related_synonym: Phenacetinum
has_related_synonym: phenacetin
id: CHEBI:8050
in subset: 3 STAR

phytochrome chromophore
type: Class
subclass of: chromophore
textual definition: A chromophore that is a linear tetrapyrrolic prosthetic group covalently attached to a large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far-red light absorbing form.
imported from: chebi.owl
has cross-reference: PMID:2909515
has_obo_namespace: chebi_ontology
has_related_synonym: phytochrome chromophores
id: CHEBI:82632
in subset: 3 STAR

animal growth promotant
type: Class
subclass of: agrochemical
textual definition: Substances that are administered to farmed animals to improve productivity by promoting weight gain, increasing muscle mass, limiting fat deposition, reducing feed consumption, and reducing waste production.
imported from: chebi.owl
has cross-reference: PMID:22444918
has cross-reference: PMID:2745641
has cross-reference: PMID:6226938
has_obo_namespace: chebi_ontology
has_related_synonym: animal growth promotants
has_related_synonym: animal growth promoter
has_related_synonym: animal growth promoters
id: CHEBI:82655
in subset: 3 STAR

EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:cyclin phosphotransferase inhibitor
has_related_synonym: ATP:cyclin phosphotransferase inhibitors
has_related_synonym: Bur1 Cdk inhibitor
has_related_synonym: Bur1 Cdk inhibitors
has_related_synonym: Bur1 inhibitor
has_related_synonym: Bur1 inhibitors
has_related_synonym: CDK inhibitor
has_related_synonym: CDK inhibitors
has_related_synonym: Cak1 inhibitor
has_related_synonym: Cak1 inhibitors
has_related_synonym: Cak1p inhibitor
has_related_synonym: Cak1p inhibitors
has_related_synonym: Cdc28p inhibitor
has_related_synonym: Cdc28p inhibitors
has_related_synonym: Cdk-activating protein kinase inhibitors
has_related_synonym: Cdk1 inhibitor
has_related_synonym: Cdk1 inhibitors
has_related_synonym: Cdk19 inhibitor
has_related_synonym: Cdk19 inhibitors
has_related_synonym: Cdk2 inhibitor
has_related_synonym: Cdk2 inhibitors
has_related_synonym: Cdk3 inhibitor
has_related_synonym: Cdk3 inhibitors
has_related_synonym: Cdk4 inhibitor
has_related_synonym: Cdk4 inhibitors
has_related_synonym: Cdk5 inhibitor
has_related_synonym: Cdk5 inhibitors
has_related_synonym: Cdk6 inhibitor
has_related_synonym: Cdk6 inhibitors
has_related_synonym: Cdk7 inhibitor
has_related_synonym: Cdk7 inhibitors
has_related_synonym: Cdk8 inhibitor
has_related_synonym: Cdk8 inhibitors
has_related_synonym: Cdk9 inhibitor
has_related_synonym: Cdk9 inhibitors
has_related_synonym: D-type cyclin kinase inhibitor
has_related_synonym: D-type cyclin kinase inhibitors
has_related_synonym: EC 2.7.11.22 (cyclin-dependent kinase) inhibitors
has_related_synonym: EC 2.7.11.22 inhibitor
has_related_synonym: EC 2.7.11.22 inhibitors
has_related_synonym: PCTAIRE-1 inhibitor
has_related_synonym: PCTAIRE-1 inhibitors
has_related_synonym: STK25 inhibitor
has_related_synonym: STK25 inhibitors
has_related_synonym: cdc2 inhibitor
has_related_synonym: cdc2 inhibitors
has_related_synonym: cdc2 kinase inhibitor
has_related_synonym: cdc2 kinase inhibitors
has_related_synonym: cdk-activating kinase inhibitor
has_related_synonym: cdk-activating kinase inhibitors
has_related_synonym: cyclin A-activated cdc2 inhibitor
has_related_synonym: cyclin A-activated cdc2 inhibitors
has_related_synonym: cyclin A-activated cdk2 inhibitor
has_related_synonym: cyclin A-activated cdk2 inhibitors
has_related_synonym: cyclin D-cdk6 kinase inhibitor
has_related_synonym: cyclin D-cdk6 kinase inhibitors
has_related_synonym: cyclin D-dependent kinase inhibitor
has_related_synonym: cyclin D-dependent kinase inhibitors
has_related_synonym: cyclin E kinase inhibitor
has_related_synonym: cyclin E kinase inhibitors
has_related_synonym: cyclin-A associated kinase inhibitor
has_related_synonym: cyclin-A associated kinase inhibitors
has_related_synonym: cyclin-dependent kinase 6 inhibitor
has_related_synonym: cyclin-dependent kinase 6 inhibitors
has_related_synonym: cyclin-dependent kinase inhibitor
has_related_synonym: cyclin-dependent kinase inhibitors
has_related_synonym: cyclin-dependent kinase-2 inhibitor
has_related_synonym: cyclin-dependent kinase-2 inhibitors
has_related_synonym: cyclin-dependent kinase-4 inhibitor
has_related_synonym: cyclin-dependent kinase-4 inhibitors
has_related_synonym: cyclin-dependent protein kinase activating kinase inhibitor
has_related_synonym: cyclin-dependent protein kinase activating kinase inhibitors
has_related_synonym: cyk inhibitor
has_related_synonym: cyk inhibitors
has_related_synonym: ndk inhibitor

EC 6.1.1.12 (aspartate--tRNA ligase) inhibitor
type: Class
subclass of: EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor
textual definition: An EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor that specifically inhibits the action of aspartate--tRNA ligase (EC 6.1.1.12).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.1.1.12 (aspartate--tRNA ligase) inhibitors
has_related_synonym: EC 6.1.1.12 inhibitor
has_related_synonym: EC 6.1.1.12 inhibitors
has_related_synonym: L-aspartate:tRNA(Asp) ligase (AMP-forming) inhibitor
has_related_synonym: L-aspartate:tRNA(Asp) ligase (AMP-forming) inhibitors
has_related_synonym: aspartic acid translase inhibitor
has_related_synonym: aspartic acid translase inhibitors
has_related_synonym: aspartyl ribonucleate synthetase inhibitor
has_related_synonym: aspartyl ribonucleate synthetase inhibitors
has_related_synonym: aspartyl ribonucleic synthetase inhibitor
has_related_synonym: aspartyl ribonucleic synthetase inhibitors
has_related_synonym: aspartyl-tRNA synthetase inhibitors
has_related_synonym: aspartyl-transfer RNA synthetase inhibitor
has_related_synonym: aspartyl-transfer RNA synthetase inhibitors
has_related_synonym: aspartyl-transfer ribonucleic acid synthetase inhibitor
has_related_synonym: aspartyl-transfer ribonucleic acid synthetase inhibitors
id: CHEBI:82756
in subset: 3 STAR

EC 3.4.22.53 (calpain-2) inhibitor
type: Class
subclass of: calpain inhibitor
textual definition: A calpain inhibitor that interferes with the action of calpain-2 (EC 3.4.22.53).
imported from: chebi.owl
has cross-reference: Wikipedia:Calpain-2
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.22.53 (calpain-2) inhibitors
has_related_synonym: EC 3.4.22.53 inhibitor
has_related_synonym: EC 3.4.22.53 inhibitors
has_related_synonym: calcium-activated neutral protease II inhibitor
has_related_synonym: calcium-activated neutral protease II inhibitors
has_related_synonym: calpain-2 (EC 3.4.22.53) inhibitor
has_related_synonym: calpain-2 (EC 3.4.22.53) inhibitors
has_related_synonym: m-calpain inhibitor
has_related_synonym: m-calpain inhibitors
has_related_synonym: milli-calpain inhibitor
has_related_synonym: milli-calpain inhibitors
id: CHEBI:82821
in subset: 3 STAR

EC 3.4.22.54 (calpain-3) inhibitor
type: Class
subclass of: calpain inhibitor
textual definition: An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of calpain-3 (EC 3.4.22.54).
imported from: chebi.owl
has cross-reference: Wikipedia:Calpain-3
has_obo_namespace: chebi_ontology
has_related_synonym: CANP 3 inhibitor
has_related_synonym: CANP 3 inhibitors
has_related_synonym: CAPN3 inhibitor
has_related_synonym: CAPN3 inhibitors
has_related_synonym: EC 3.4.22.54 (calpain-3) inhibitors
has_related_synonym: EC 3.4.22.54 inhibitor
has_related_synonym: EC 3.4.22.54 inhibitors
has_related_synonym: calcium-activated neutral proteinase 3 inhibitor
has_related_synonym: calcium-activated neutral proteinase 3 inhibitors
has_related_synonym: calpain 3 inhibitor
has_related_synonym: calpain 3 inhibitors
has_related_synonym: calpain L3 inhibitor
has_related_synonym: calpain L3 inhibitors
has_related_synonym: calpain p94 inhibitor
has_related_synonym: calpain p94 inhibitors
has_related_synonym: calpain-3 (EC 3.4.22.54) inhibitor
has_related_synonym: calpain-3 (EC 3.4.22.54) inhibitors
has_related_synonym: muscle calpain inhibitor
has_related_synonym: muscle calpain inhibitors
has_related_synonym: muscle-specific calcium-activated neutral protease 3 inhibitor
has_related_synonym: muscle-specific calcium-activated neutral protease 3 inhibitors
has_related_synonym: p94 inhibitor
has_related_synonym: p94 inhibitors
id: CHEBI:82823
in subset: 3 STAR

calpain inhibitor
type: Class
subclass of: cysteine protease inhibitor
subclass of: EC 3.4.22.* (cysteine endopeptidase) inhibitor
textual definition: An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of any calpain.
imported from: chebi.owl
has cross-reference: PMID:22253611
has cross-reference: PMID:22863139
has cross-reference: Wikipedia:Calpain
has_obo_namespace: chebi_ontology
has_related_synonym: calpain inhibitors
id: CHEBI:82824
in subset: 3 STAR

glucocorticoid receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates glucocorticoid receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glucocorticoid receptor antagonists
id: CHEBI:82891
in subset: 3 STAR

gut flora metabolite
type: Class
subclass of: metabolite
textual definition: Metabolites produced by the gut microbiota or microorganisms (e.g. bacteria and fungi) that live in the digestive tracts of animals.
imported from: chebi.owl
has cross-reference: Wikipedia:Gut_flora
has_obo_namespace: chebi_ontology
has_related_synonym: gut flora metabolites
id: CHEBI:82933
in subset: 3 STAR

EC 3.4.24.11 (neprilysin) inhibitor
type: Class
subclass of: EC 3.4.24.* (metalloendopeptidase) inhibitor
textual definition: An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of neprilysin (EC 3.4.24.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Neprilysin
has_obo_namespace: chebi_ontology
has_related_synonym: CALLA (common acute lymphoblastic leukemia-associated) antigens inhibitor
has_related_synonym: CALLA (common acute lymphoblastic leukemia-associated) antigens inhibitors
has_related_synonym: CALLA antigen inhibitor
has_related_synonym: CALLA antigen inhibitors
has_related_synonym: CALLA glycoprotein inhibitor
has_related_synonym: CALLA glycoprotein inhibitors
has_related_synonym: CALLA glycoproteins inhibitor
has_related_synonym: CALLA glycoproteins inhibitors
has_related_synonym: CALLA inhibitor
has_related_synonym: CALLA inhibitors
has_related_synonym: CD10 inhibitor
has_related_synonym: CD10 inhibitors
has_related_synonym: EC 3.4.24.11 (neprilysin) inhibitors
has_related_synonym: EC 3.4.24.11 inhibitor
has_related_synonym: EC 3.4.24.11 inhibitors
has_related_synonym: NEP inhibitor
has_related_synonym: NEP inhibitors
has_related_synonym: acute lymphoblastic leukemia antigen inhibitor
has_related_synonym: acute lymphoblastic leukemia antigen inhibitors
has_related_synonym: common acute lymphoblastic leukemia antigen inhibitor
has_related_synonym: common acute lymphoblastic leukemia antigen inhibitors
has_related_synonym: common acute lymphoblastic leukemia-associated antigens inhibitor
has_related_synonym: common acute lymphoblastic leukemia-associated antigens inhibitors
has_related_synonym: endopeptidase 24.11 inhibitor
has_related_synonym: endopeptidase 24.11 inhibitors
has_related_synonym: endopeptidase inhibitor
has_related_synonym: endopeptidase inhibitors
has_related_synonym: endopeptidase-2 inhibitor
has_related_synonym: endopeptidase-2 inhibitors
has_related_synonym: enkephalinase inhibitor
has_related_synonym: enkephalinase inhibitors
has_related_synonym: kidney-brush-border neutral endopeptidase inhibitor
has_related_synonym: kidney-brush-border neutral endopeptidase inhibitors
has_related_synonym: kidney-brush-border neutral peptidase inhibitor
has_related_synonym: kidney-brush-border neutral peptidase inhibitors
has_related_synonym: kidney-brush-border neutral proteinase inhibitor
has_related_synonym: kidney-brush-border neutral proteinase inhibitors
has_related_synonym: membrane metalloendopeptidase inhibitor
has_related_synonym: membrane metalloendopeptidase inhibitors
has_related_synonym: neprilysin (EC 3.4.24.11) inhibitor
has_related_synonym: neprilysin (EC 3.4.24.11) inhibitors
has_related_synonym: neprilysin inhibitor
has_related_synonym: neprilysin inhibitors
has_related_synonym: neutral endopeptidase 24.11 inhibitor
has_related_synonym: neutral endopeptidase 24.11 inhibitors
has_related_synonym: neutral endopeptidase inhibitor
has_related_synonym: neutral endopeptidase inhibitors
has_related_synonym: neutral metallendopeptidase inhibitor
has_related_synonym: neutral metallendopeptidase inhibitors
id: CHEBI:82973
in subset: 3 STAR

EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor
type: Class
subclass of: EC 3.4.24.* (metalloendopeptidase) inhibitor
textual definition: An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of endothelin-converting enzyme 1 (EC 3.4.24.71).
imported from: chebi.owl
has cross-reference: Wikipedia:Endothelin-converting_enzyme_1
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitors
has_related_synonym: EC 3.4.24.71 inhibitor
has_related_synonym: EC 3.4.24.71 inhibitors
has_related_synonym: ECE-1 inhibitor
has_related_synonym: ECE-1 inhibitors
has_related_synonym: endothelin-converting enzyme 1 (EC 3.4.24.71) inhibitor
has_related_synonym: endothelin-converting enzyme 1 (EC 3.4.24.71) inhibitors
has_related_synonym: endothelin-converting enzyme 1 inhibitor
has_related_synonym: endothelin-converting enzyme 1 inhibitors
has_related_synonym: endothelin-converting enzyme inhibitor
has_related_synonym: endothelin-converting enzyme inhibitors
id: CHEBI:82974
in subset: 3 STAR

EC 4.1.2.27 (sphinganine-1-phosphate aldolase) inhibitor
type: Class
subclass of: EC 4.1.2.* (aldehyde-lyase) inhibitor
textual definition: An EC 4.1.2.* (aldehyde-lyase) inhibitor that interferes with the action of sphinganine-1-phosphate aldolase (EC 4.1.2.27).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.1.2.27 (sphinganine-1-phosphate aldolase) inhibitors
has_related_synonym: EC 4.1.2.27 inhibitor
has_related_synonym: EC 4.1.2.27 inhibitors
has_related_synonym: S1P lyase inhibitor
has_related_synonym: S1P lyase inhibitors
has_related_synonym: dihydrosphingosine 1-phosphate aldolase inhibitor
has_related_synonym: dihydrosphingosine 1-phosphate aldolase inhibitors
has_related_synonym: sphinganine-1-phosphate alkanal-lyase inhibitor
has_related_synonym: sphinganine-1-phosphate alkanal-lyase inhibitors
has_related_synonym: sphinganine-1-phosphate lyase inhibitor
has_related_synonym: sphinganine-1-phosphate lyase inhibitors
has_related_synonym: sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming) inhibitor
has_related_synonym: sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming) inhibitors
has_related_synonym: sphinganine-1-phosphate palmitaldehyde-lyase inhibitor
has_related_synonym: sphinganine-1-phosphate palmitaldehyde-lyase inhibitors
has_related_synonym: sphingosine-1-phosphate aldolase inhibitor
has_related_synonym: sphingosine-1-phosphate aldolase inhibitors
has_related_synonym: sphingosine-1-phosphate lyase inhibitor
has_related_synonym: sphingosine-1-phosphate lyase inhibitors
id: CHEBI:83034
in subset: 3 STAR

EC 4.1.2.* (aldehyde-lyase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: An EC 4.1.* (C-C lyase) inhibitor that interferes with the action of any aldehyde-lyase (EC 4.1.2.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.1.2.* (aldehyde-lyase) inhibitors
has_related_synonym: EC 4.1.2.* (aldehyde-lyases) inhibitor
has_related_synonym: EC 4.1.2.* (aldehyde-lyases) inhibitors
has_related_synonym: EC 4.1.2.* inhibitor
has_related_synonym: EC 4.1.2.* inhibitors
id: CHEBI:83035
in subset: 3 STAR

Daphnia galeata metabolite
type: Class
subclass of: Daphnia metabolite
textual definition: A Daphnia metabolite produced by the species Daphnia galeata.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Daphnia galeata metabolites
id: CHEBI:83038
in subset: 3 STAR

crustacean metabolite
type: Class
subclass of: animal metabolite
textual definition: An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: crustacean metabolites
id: CHEBI:83039
in subset: 3 STAR

Daphnia magna metabolite
type: Class
subclass of: Daphnia metabolite
textual definition: A Daphnia metabolite produced by the species Daphnia magna.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Daphnia magna metabolites
id: CHEBI:83056
in subset: 3 STAR

Daphnia metabolite
type: Class
subclass of: crustacean metabolite
textual definition: A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia
imported from: chebi.owl
has cross-reference: Wikipedia:Daphnia
has_obo_namespace: chebi_ontology
has_related_synonym: Daphnia metabolites
id: CHEBI:83057
in subset: 3 STAR

EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
type: Class
subclass of: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor
textual definition: An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of succinate dehydrogenase (quinone), EC 1.3.5.1.
imported from: chebi.owl
has cross-reference: Wikipedia:Succinate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitors
has_related_synonym: EC 1.3.5.1 inhibitor
has_related_synonym: EC 1.3.5.1 inhibitors
has_related_synonym: SDH inhibitor
has_related_synonym: SDH inhibitors
has_related_synonym: complex II inhibitor
has_related_synonym: complex II inhibitors
has_related_synonym: succinate dehydrogenase (ubiquinone) inhibitor
has_related_synonym: succinate dehydrogenase (ubiquinone) inhibitors
has_related_synonym: succinate dehydrogenase complex inhibitor
has_related_synonym: succinate dehydrogenase complex inhibitors
has_related_synonym: succinate dehydrogenase inhibitor
has_related_synonym: succinate dehydrogenase inhibitors
has_related_synonym: succinate:quinone oxidoreductase inhibitor
has_related_synonym: succinate:quinone oxidoreductase inhibitors
has_related_synonym: succinate:ubiquinone oxidoreductase inhibitor
has_related_synonym: succinate:ubiquinone oxidoreductase inhibitors
has_related_synonym: succinic dehydrogenase inhibitor
has_related_synonym: succinic dehydrogenase inhibitors
id: CHEBI:83072
in subset: 3 STAR

kairomone
type: Class
subclass of: semiochemical
textual definition: A semiochemical used for inter-species chemical communication in a way that benefits an individual of another species that receives the chemical signal.
imported from: chebi.owl
has cross-reference: Wikipedia:Kairomone
has_obo_namespace: chebi_ontology
has_related_synonym: kairomones
id: CHEBI:83074
in subset: 3 STAR

Daphnia pulex metabolite
type: Class
subclass of: Daphnia metabolite
textual definition: A Daphnia metabolite produced by the species Daphnia pulex.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Daphnia pulex metabolites
id: CHEBI:83075
in subset: 3 STAR

Daphnia tenebrosa metabolite
type: Class
subclass of: Daphnia metabolite
textual definition: A Daphnia metabolite produced by the species Daphnia tenebrosa.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Daphnia tenebrosa metabolites
id: CHEBI:83146
in subset: 3 STAR

EC 6.2.1.* (acid-thiol ligase) inhibitor
type: Class
subclass of: EC 6.2.* (C-S bond-forming ligase) inhibitor
textual definition: An EC 6.2.* (C-S bond-forming ligase) inhibitor that interferes with the action of an acid-thiol ligase inhibitor (EC 6.2.1.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.2.1.* (acid-thiol ligase) inhibitors
has_related_synonym: EC 6.2.1.* (acid-thiol ligases) inhibitor
has_related_synonym: EC 6.2.1.* (acid-thiol ligases) inhibitors
has_related_synonym: EC 6.2.1.* inhibitor
has_related_synonym: EC 6.2.1.* inhibitors
id: CHEBI:83156
in subset: 3 STAR

EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor
type: Class
subclass of: EC 6.2.1.* (acid-thiol ligase) inhibitor
textual definition: An EC 6.2.1.* (acid-thiol ligase) inhibitor that interferes with the action of a long-chain-fatty-acid--CoA ligase (EC 6.2.1.3).
imported from: chebi.owl
has cross-reference: Wikipedia:Long-chain-fatty-acid-CoA_ligase
has_obo_namespace: chebi_ontology
has_related_synonym: ACS3 inhibitor
has_related_synonym: ACS3 inhibitors
has_related_synonym: EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitors
has_related_synonym: EC 6.2.1.3 inhibitor
has_related_synonym: EC 6.2.1.3 inhibitors
has_related_synonym: FAA1 inhibitor
has_related_synonym: FAA1 inhibitors
has_related_synonym: LCFA synthetase inhibitor
has_related_synonym: LCFA synthetase inhibitors
has_related_synonym: acyl coenzyme A synthetase inhibitor
has_related_synonym: acyl coenzyme A synthetase inhibitors
has_related_synonym: acyl-CoA ligase inhibitor
has_related_synonym: acyl-CoA ligase inhibitors
has_related_synonym: acyl-CoA synthetase inhibitor
has_related_synonym: acyl-CoA synthetase inhibitors
has_related_synonym: acyl-activating enzyme inhibitor
has_related_synonym: acyl-activating enzyme inhibitors
has_related_synonym: acyl-coenzyme A ligase inhibitor
has_related_synonym: acyl-coenzyme A ligase inhibitors
has_related_synonym: arachidonyl-CoA synthetase inhibitor
has_related_synonym: arachidonyl-CoA synthetase inhibitors
has_related_synonym: fatty acid CoA ligase inhibitor
has_related_synonym: fatty acid CoA ligase inhibitors
has_related_synonym: fatty acid elongase inhibitor
has_related_synonym: fatty acid elongase inhibitors
has_related_synonym: fatty acid thiokinase (long chain) inhibitor
has_related_synonym: fatty acid thiokinase (long chain) inhibitors
has_related_synonym: fatty acyl-coenzyme A synthetase inhibitor
has_related_synonym: fatty acyl-coenzyme A synthetase inhibitors
has_related_synonym: lignoceroyl-CoA synthase inhibitor
has_related_synonym: lignoceroyl-CoA synthase inhibitors
has_related_synonym: long chain fatty acyl-CoA synthetase inhibitor
has_related_synonym: long chain fatty acyl-CoA synthetase inhibitors
has_related_synonym: long-chain acyl CoA synthetase inhibitor
has_related_synonym: long-chain acyl CoA synthetase inhibitors
has_related_synonym: long-chain acyl-CoA synthetase I inhibitor
has_related_synonym: long-chain acyl-CoA synthetase I inhibitors
has_related_synonym: long-chain acyl-CoA synthetase II inhibitor
has_related_synonym: long-chain acyl-CoA synthetase II inhibitors
has_related_synonym: long-chain acyl-coenzyme A synthetase inhibitor
has_related_synonym: long-chain acyl-coenzyme A synthetase inhibitors
has_related_synonym: long-chain fatty acid:CoA ligase (AMP-forming) inhibitor
has_related_synonym: long-chain fatty acid:CoA ligase (AMP-forming) inhibitors
has_related_synonym: long-chain fatty acyl coenzyme A synthetase inhibitor
has_related_synonym: long-chain fatty acyl coenzyme A synthetase inhibitors
has_related_synonym: oleoyl-CoA synthetase inhibitor
has_related_synonym: oleoyl-CoA synthetase inhibitors
has_related_synonym: palmitoyl coenzyme A synthetase inhibitor
has_related_synonym: palmitoyl coenzyme A synthetase inhibitors
has_related_synonym: palmitoyl-CoA ligase inhibitor
has_related_synonym: palmitoyl-CoA ligase inhibitors
has_related_synonym: palmitoyl-CoA synthase inhibitor
has_related_synonym: palmitoyl-CoA synthase inhibitors
has_related_synonym: pristanoyl-CoA synthetase inhibitor
has_related_synonym: pristanoyl-CoA synthetase inhibitors
has_related_synonym: stearoyl-CoA synthetase inhibitor
has_related_synonym: stearoyl-CoA synthetase inhibitors
has_related_synonym: thiokinase inhibitor
has_related_synonym: thiokinase inhibitors
id: CHEBI:83157
in subset: 3 STAR

orexin receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates orexin receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Orexin_antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: orexin receptor antagonists
id: CHEBI:83296
in subset: 3 STAR

protease-activated receptor-1 antagonist
type: Class
subclass of: G-protein-coupled receptor antagonist
textual definition: An antagonist at the protease-activated receptor-1.
imported from: chebi.owl
has cross-reference: PMID:20655904
has cross-reference: PMID:25777282
has cross-reference: PMID:35349275
has cross-reference: Wikipedia:Coagulation_factor_II_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: PAR-1 antagonist
has_related_synonym: PAR-1 antagonists
has_related_synonym: PAR-1 receptor antagonist
has_related_synonym: PAR-1 receptor antagonists
has_related_synonym: PAR1 antagonist
has_related_synonym: PAR1 antagonists
has_related_synonym: coagulation factor II (thrombin) receptor antagonist
has_related_synonym: coagulation factor II (thrombin) receptor antagonists
has_related_synonym: coagulation factor II receptor antagonist
has_related_synonym: coagulation factor II receptor antagonists
has_related_synonym: coagulation factor II thrombin receptor antagonist
has_related_synonym: coagulation factor II thrombin receptor antagonists
has_related_synonym: protease activated receptor 1 antagonist
has_related_synonym: protease activated receptor 1 antagonists
has_related_synonym: protease-activated receptor 1 antagonist
has_related_synonym: protease-activated receptor 1 antagonists
has_related_synonym: protease-activated receptor-1 antagonists
has_related_synonym: proteinase-activated receptor 1 antagonist
has_related_synonym: proteinase-activated receptor 1 antagonists
id: CHEBI:83313
in subset: 3 STAR

EC 1.14.13.72 (methylsterol monooxygenase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of methylsterol monooxygenase (EC 1.14.13.72).
imported from: chebi.owl
has cross-reference: Wikipedia:Methylsterol_monooxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitor
has_related_synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitors
has_related_synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitor
has_related_synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitors
has_related_synonym: 4-methylsterol oxidase inhibitor
has_related_synonym: 4-methylsterol oxidase inhibitors
has_related_synonym: EC 1.14.13.72 (ethylsterol monooxygenase) inhibitors
has_related_synonym: EC 1.14.13.72 inhibitor
has_related_synonym: EC 1.14.13.72 inhibitors
has_related_synonym: methylsterol hydroxylase inhibitor
has_related_synonym: methylsterol hydroxylase inhibitors
has_related_synonym: methylsterol monooxygenase (EC 1.14.13.72) inhibitor
has_related_synonym: methylsterol monooxygenase (EC 1.14.13.72) inhibitors
has_related_synonym: methylsterol monooxygenase inhibitor
has_related_synonym: methylsterol monooxygenase inhibitors
id: CHEBI:83316
in subset: 3 STAR

sterol biosynthesis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any compound that inhibits the biosynthesis of any sterol.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sterol biosynthesis inhibitors
id: CHEBI:83317
in subset: 3 STAR

EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor
type: Class
subclass of: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of Delta(14)-sterol reductase (EC 1.3.1.70).
imported from: chebi.owl
has cross-reference: Wikipedia:Delta14-sterol_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitor
has_related_synonym: 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitors
has_related_synonym: C-14 sterol reductase inhibitor
has_related_synonym: C-14 sterol reductase inhibitors
has_related_synonym: Delta(14)-sterol reductase (EC 1.3.1.70) inhibitor
has_related_synonym: Delta(14)-sterol reductase (EC 1.3.1.70) inhibitors
has_related_synonym: Delta(14)-sterol reductase inhibitor
has_related_synonym: Delta(14)-sterol reductase inhibitors
has_related_synonym: EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitors
has_related_synonym: EC 1.3.1.70 inhibitor
has_related_synonym: EC 1.3.1.70 inhibitors
has_related_synonym: sterol C14-reductase inhibitor
has_related_synonym: sterol C14-reductase inhibitors
id: CHEBI:83319
in subset: 3 STAR

marine xenobiotic metabolite
type: Class
subclass of: xenobiotic metabolite
subclass of: marine metabolite
textual definition: Any metabolite produced by metabolism of a xenobiotic compound in marine macro- and microorganisms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: marine xenobiotic metabolites
id: CHEBI:83399
in subset: 3 STAR

steatosis inducing agent
type: Class
subclass of: biochemical role
textual definition: Any agent capable of inducing steatosis, a pathological condition characterised by accumulation or abnormal retention of fats within a cell.
imported from: chebi.owl
has cross-reference: Wikipedia:Steatosis
has_obo_namespace: chebi_ontology
has_related_synonym: steatosis inducing agents
has_related_synonym: steatosis inducing drug
has_related_synonym: steatosis inducing drugs
id: CHEBI:83609
in subset: 3 STAR

hepatic steatosis inducing agent
type: Class
subclass of: hepatotoxic agent
subclass of: steatosis inducing agent
textual definition: Any hepatotoxic agent capable of inducing liver steatosis or fatty liver disease.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hepatic steatosis inducing agents
has_related_synonym: hepatic steatosis inducing drug
has_related_synonym: hepatic steatosis inducing drugs
id: CHEBI:83612
in subset: 3 STAR

sterol demethylation inhibitor
type: Class
subclass of: antifungal agent
subclass of: sterol biosynthesis inhibitor
textual definition: A sterol biosynthesis inhibitor that acts by inhibiting the C14 demethylation step within fungal steroid biosynthesis.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sterol demethylation inhibitors
id: CHEBI:83734
in subset: 3 STAR

phospholipid biosynthesis inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any compound that inhibits the biosynthesis of any phospholipid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phospholipid biosynthesis inhibitors
id: CHEBI:83741
in subset: 3 STAR

EC 2.4.1.231 [alpha,alpha-trehalose phosphorylase (configuration-retaining)] inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of alpha,alpha-trehalose phosphorylase (configuration-retaining) (EC 2.4.1.231).
imported from: chebi.owl
has cross-reference: Wikipedia:Alpha,alpha-trehalose_phosphorylase_(configuration-retaining)
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.231 [alpha,alpha-trehalose phosphorylase (configuration-retaining)] inhibitors
has_related_synonym: EC 2.4.1.231 inhibitor
has_related_synonym: EC 2.4.1.231 inhibitors
has_related_synonym: alpha,alpha-trehalose phosphorylase (configuration-retaining) (EC 2.4.1.231) inhibitor
has_related_synonym: alpha,alpha-trehalose phosphorylase (configuration-retaining) (EC 2.4.1.231) inhibitors
has_related_synonym: alpha,alpha-trehalose phosphorylase (configuration-retaining) inhibitor
has_related_synonym: alpha,alpha-trehalose phosphorylase (configuration-retaining) inhibitors
has_related_synonym: alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase inhibitor
has_related_synonym: alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase inhibitors
has_related_synonym: trehalose phosphorylase inhibitor
has_related_synonym: trehalose phosphorylase inhibitors
id: CHEBI:83757
in subset: 3 STAR

EC 2.4.1.64 (alpha,alpha-trehalose phosphorylase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of alpha,alpha-trehalose phosphorylase (EC 2.4.1.64).
imported from: chebi.owl
has cross-reference: Wikipedia:Alpha,alpha-trehalose_phosphorylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.1.64 (alpha,alpha-trehalose phosphorylase) inhibitors
has_related_synonym: EC 2.4.1.64 inhibitor
has_related_synonym: EC 2.4.1.64 inhibitors
has_related_synonym: alpha,alpha-trehalose phosphorylase (EC 2.4.1.64) inhibitor
has_related_synonym: alpha,alpha-trehalose phosphorylase (EC 2.4.1.64) inhibitors
has_related_synonym: alpha,alpha-trehalose phosphorylase inhibitor
has_related_synonym: alpha,alpha-trehalose phosphorylase inhibitors
has_related_synonym: alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase inhibitor
has_related_synonym: alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase inhibitors
has_related_synonym: trehalose phosphorylase inhibitor
has_related_synonym: trehalose phosphorylase inhibitors
id: CHEBI:83760
in subset: 3 STAR

EC 3.2.1.28 (alpha,alpha-trehalase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of alpha,alpha-trehalase (EC 2.4.1.28).
imported from: chebi.owl
has cross-reference: Wikipedia:Alpha,alpha-trehalase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.2.1.28 (alpha,alpha-trehalase) inhibitors
has_related_synonym: EC 3.2.1.28 inhibitor
has_related_synonym: EC 3.2.1.28 inhibitors
has_related_synonym: alpha,alpha-trehalase (EC 3.2.1.28) inhibitor
has_related_synonym: alpha,alpha-trehalase (EC 3.2.1.28) inhibitors
has_related_synonym: alpha,alpha-trehalase inhibitor
has_related_synonym: alpha,alpha-trehalase inhibitors
id: CHEBI:83762
in subset: 3 STAR

nonstructural protein 5A inhibitor
type: Class
subclass of: antiviral agent
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of nonstructural protein 5A.
imported from: chebi.owl
has cross-reference: Wikipedia:NS5A
has_obo_namespace: chebi_ontology
has_related_synonym: HCV non-structural protein 5A inhibitor
has_related_synonym: HCV non-structural protein 5A inhibitors
has_related_synonym: NS5A inhibitor
has_related_synonym: NS5A inhibitors
has_related_synonym: NS5A replication complex inhibitor
has_related_synonym: NS5A replication complex inhibitors
has_related_synonym: nonstructural protein 5A inhibitors
id: CHEBI:83799
in subset: 3 STAR

EC 4.2.1.94 (scytalone dehydratase) inhibitor
type: Class
subclass of: EC 4.2.1.* (hydro-lyases) inhibitor
textual definition: An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of scytalone dehydratase (EC 4.2.1.94).
imported from: chebi.owl
has cross-reference: Wikipedia:Scytalone_dehydratase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.2.1.94 (scytalone dehydratase) inhibitors
has_related_synonym: EC 4.2.1.94 inhibitor
has_related_synonym: EC 4.2.1.94 inhibitors
has_related_synonym: scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) inhibitor
has_related_synonym: scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) inhibitors
has_related_synonym: scytalone 7,8-hydro-lyase inhibitor
has_related_synonym: scytalone 7,8-hydro-lyase inhibitors
id: CHEBI:84012
in subset: 3 STAR

EC 3.4.24.24 (gelatinase A) inhibitor
type: Class
subclass of: EC 3.4.24.* (metalloendopeptidase) inhibitor
textual definition: An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of gelatinase A (EC 3.4.24.24).
imported from: chebi.owl
has cross-reference: Wikipedia:MMP2
has_obo_namespace: chebi_ontology
has_related_synonym: 72 kDa gelatinase inhibitor
has_related_synonym: 72 kDa gelatinase inhibitors
has_related_synonym: 72 kDa gelatinase type A inhibitor
has_related_synonym: 72 kDa gelatinase type A inhibitors
has_related_synonym: EC 3.4.24.35 (gelatinase B) inhibitors
has_related_synonym: EC 3.4.24.35 inhibitor
has_related_synonym: EC 3.4.24.35 inhibitors
has_related_synonym: MMP 2 inhibitor
has_related_synonym: MMP 2 inhibitors
has_related_synonym: collagenase IV inhibitor
has_related_synonym: collagenase IV inhibitors
has_related_synonym: collagenase type IV inhibitor
has_related_synonym: collagenase type IV inhibitors
has_related_synonym: matrix metalloproteinase 2 inhibitor
has_related_synonym: matrix metalloproteinase 2 inhibitors
has_related_synonym: type IV collagen metalloproteinase inhibitor
has_related_synonym: type IV collagen metalloproteinase inhibitors
has_related_synonym: type IV collagenase inhibitor
has_related_synonym: type IV collagenase inhibitors
has_related_synonym: type IV collagenase/gelatinase inhibitor
has_related_synonym: type IV collagenase/gelatinase inhibitors
id: CHEBI:84036
in subset: 3 STAR

human urinary metabolite
type: Class
subclass of: human metabolite
textual definition: Any metabolite (endogenous or exogenous) found in human urine samples.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: human urinary metabolites
id: CHEBI:84087
in subset: 3 STAR

EC 3.5.1.19 (nicotinamidase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of nicotinamidase (EC 3.5.1.19).
imported from: chebi.owl
has cross-reference: Wikipedia:Nicotinamidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.5.1.19 (nicotinamidase) inhibitors
has_related_synonym: EC 3.5.1.19 inhibitor
has_related_synonym: EC 3.5.1.19 inhibitors
has_related_synonym: YNDase inhibitor
has_related_synonym: YNDase inhibitors
has_related_synonym: nicotinamidase (EC 3.5.1.19) inhibitor
has_related_synonym: nicotinamidase (EC 3.5.1.19) inhibitors
has_related_synonym: nicotinamidase inhibitor
has_related_synonym: nicotinamidase inhibitors
has_related_synonym: nicotinamide amidase inhibitor
has_related_synonym: nicotinamide amidase inhibitors
has_related_synonym: nicotinamide amidohydrolase inhibitor
has_related_synonym: nicotinamide amidohydrolase inhibitors
has_related_synonym: nicotinamide deaminase inhibitor
has_related_synonym: nicotinamide deaminase inhibitors
id: CHEBI:84264
in subset: 3 STAR

EC 3.4.21.64 (peptidase K) inhibitor
type: Class
subclass of: protease inhibitor
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of peptidase K (EC 3.4.21.64).
imported from: chebi.owl
has cross-reference: Wikipedia:Proteinase_K
has_obo_namespace: chebi_ontology
has_related_synonym: EC 3.4.21.64 (peptidase K) inhibitors
has_related_synonym: EC 3.4.21.64 inhibitor
has_related_synonym: EC 3.4.21.64 inhibitors
has_related_synonym: Tritirachium album proteinase K inhibitor
has_related_synonym: Tritirachium album proteinase K inhibitors
has_related_synonym: Tritirachium album serine proteinase inhibitor
has_related_synonym: Tritirachium album serine proteinase inhibitors
has_related_synonym: endopeptidase K inhibitor
has_related_synonym: endopeptidase K inhibitors
has_related_synonym: peptidase K inhibitor
has_related_synonym: peptidase K inhibitors
has_related_synonym: proteinase K inhibitor
has_related_synonym: proteinase K inhibitors
id: CHEBI:84297
in subset: 3 STAR

algal metabolite
type: Class
subclass of: eukaryotic metabolite
textual definition: Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: algal metabolites
id: CHEBI:84735
in subset: 3 STAR

EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor
type: Class
subclass of: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
textual definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of arylamine N-acetyltransferase (EC 2.3.1.5).
imported from: chebi.owl
has cross-reference: PMID:18642144
has cross-reference: PMID:21204000
has cross-reference: Wikipedia:Arylamine_N-acetyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: 2-naphthylamine N-acetyltransferase inhibitor
has_related_synonym: 2-naphthylamine N-acetyltransferase inhibitors
has_related_synonym: 4-aminobiphenyl N-acetyltransferase inhibitor
has_related_synonym: 4-aminobiphenyl N-acetyltransferase inhibitors
has_related_synonym: EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitors
has_related_synonym: EC 2.3.1.5 inhibitor
has_related_synonym: EC 2.3.1.5 inhibitora
has_related_synonym: N-acetyltransferase inhibitor
has_related_synonym: N-acetyltransferase inhibitors
has_related_synonym: acetyl CoA-arylamine N-acetyltransferase inhibitor
has_related_synonym: acetyl CoA-arylamine N-acetyltransferase inhibitors
has_related_synonym: acetyl-CoA:arylamine N-acetyltransferase inhibitor
has_related_synonym: acetyl-CoA:arylamine N-acetyltransferase inhibitors
has_related_synonym: arylamine N-acetyltransferase (EC 2.3.1.5) inhibitor
has_related_synonym: arylamine N-acetyltransferase (EC 2.3.1.5) inhibitors
has_related_synonym: arylamine N-acetyltransferase inhibitor
has_related_synonym: arylamine N-acetyltransferase inhibitors
has_related_synonym: arylamine acetylase inhibitor
has_related_synonym: arylamine acetylase inhibitors
has_related_synonym: arylamine acetyltransferase inhibitor
has_related_synonym: arylamine acetyltransferase inhibitors
has_related_synonym: beta-naphthylamine N-acetyltransferase inhibitor
has_related_synonym: beta-naphthylamine N-acetyltransferase inhibitors
has_related_synonym: indoleamine N-acetyltransferase inhibitor
has_related_synonym: indoleamine N-acetyltransferase inhibitors
has_related_synonym: p-aminosalicylate N-acetyltransferase inhibitor
has_related_synonym: p-aminosalicylate N-acetyltransferase inhibitors
has_related_synonym: serotonin N-acetyltransferase inhibitor
has_related_synonym: serotonin N-acetyltransferase inhibitors
has_related_synonym: serotonin acetyltransferase inhibitor
has_related_synonym: serotonin acetyltransferase inhibitors
id: CHEBI:84799
in subset: 3 STAR

EC 2.4.1.1 (glycogen phosphorylase) inhibitor
type: Class
subclass of: EC 2.4.1.* (hexosyltransferase) inhibitor
textual definition: Any EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of glycogen phosphorylase (EC 2.4.1.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Glycogen_phosphorylase
has_obo_namespace: chebi_ontology
has_related_synonym: (1->4)-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitor
has_related_synonym: (1->4)-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitors
has_related_synonym: 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitor
has_related_synonym: 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitors
has_related_synonym: 1,4-alpha-glucan phosphorylase inhibitor
has_related_synonym: 1,4-alpha-glucan phosphorylase inhibitors
has_related_synonym: EC 2.4.1.1 (glycogen phosphorylase) inhibitors
has_related_synonym: EC 2.4.1.1 inhibitor
has_related_synonym: EC 2.4.1.1 inhibitors
has_related_synonym: alpha-glucan phosphorylase inhibitor
has_related_synonym: alpha-glucan phosphorylase inhibitors
has_related_synonym: amylopectin phosphorylase inhibitor
has_related_synonym: amylopectin phosphorylase inhibitors
has_related_synonym: amylophosphorylase inhibitor
has_related_synonym: amylophosphorylase inhibitors
has_related_synonym: glucan phosphorylase inhibitor
has_related_synonym: glucan phosphorylase inhibitors
has_related_synonym: glucosan phosphorylase inhibitor
has_related_synonym: glucosan phosphorylase inhibitors
has_related_synonym: glycogen phosphorylase (EC 2.4.1.1) inhibitor
has_related_synonym: glycogen phosphorylase (EC 2.4.1.1) inhibitors
has_related_synonym: glycogen phosphorylase inhibitor
has_related_synonym: glycogen phosphorylase inhibitors
has_related_synonym: granulose phosphorylase inhibitor
has_related_synonym: granulose phosphorylase inhibitors
has_related_synonym: maltodextrin phosphorylase inhibitor
has_related_synonym: maltodextrin phosphorylase inhibitors
has_related_synonym: muscle phosphorylase a and b inhibitor
has_related_synonym: muscle phosphorylase a and b inhibitors
has_related_synonym: muscle phosphorylase inhibitor
has_related_synonym: muscle phosphorylase inhibitors
has_related_synonym: myophosphorylase inhibitor
has_related_synonym: myophosphorylase inhibitors
has_related_synonym: phosphorylase inhibitor
has_related_synonym: phosphorylase inhibitors
has_related_synonym: polyphosphorylase inhibitor
has_related_synonym: polyphosphorylase inhibitors
has_related_synonym: potato phosphorylase inhibitor
has_related_synonym: potato phosphorylase inhibitors
has_related_synonym: starch phosphorylase inhibitor
has_related_synonym: starch phosphorylase inhibitors
id: CHEBI:84800
in subset: 3 STAR

EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: Any EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of inositol-trisphosphate 3-kinase (EC 2.7.1.127).
imported from: chebi.owl
has cross-reference: Wikipedia:Inositol-trisphosphate_3-kinase
has_obo_namespace: chebi_ontology
has_related_synonym: 1D-myo-inositol-trisphosphate 3-kinase inhibitor
has_related_synonym: 1D-myo-inositol-trisphosphate 3-kinase inhibitors
has_related_synonym: ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase inhibitor
has_related_synonym: ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase inhibitors
has_related_synonym: EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitors
has_related_synonym: EC 2.7.1.127 inhibitor
has_related_synonym: EC 2.7.1.127 inhibitors
has_related_synonym: IP3 3-kinase inhibitor
has_related_synonym: IP3 3-kinase inhibitors
has_related_synonym: IP3K inhibitor
has_related_synonym: IP3K inhibitors
has_related_synonym: Ins(1,4,5)P3 3-kinase inhibitor
has_related_synonym: Ins(1,4,5)P3 3-kinase inhibitors
has_related_synonym: inositol 1,4,5-trisphosphate 3-kinase inhibitor
has_related_synonym: inositol 1,4,5-trisphosphate 3-kinase inhibitors
has_related_synonym: inositol-trisphosphate 3-kinase (EC 2.7.1.127) inhibitor
has_related_synonym: inositol-trisphosphate 3-kinase (EC 2.7.1.127) inhibitors
has_related_synonym: inositol-trisphosphate 3-kinase inhibitor
has_related_synonym: inositol-trisphosphate 3-kinase inhibitors
id: CHEBI:84801
in subset: 3 STAR

EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor
type: Class
subclass of: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
textual definition: Any EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of inositol-polyphosphate multikinase (EC 2.7.1.151).
imported from: chebi.owl
has cross-reference: Wikipedia:Inositol-polyphosphate_multikinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase inhibitor
has_related_synonym: ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase inhibitors
has_related_synonym: ArgRIII inhibitor
has_related_synonym: ArgRIII inhibitors
has_related_synonym: AtIpk2alpha inhibitor
has_related_synonym: AtIpk2alpha inhibitors
has_related_synonym: AtIpk2beta inhibitor
has_related_synonym: AtIpk2beta inhibitors
has_related_synonym: EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitors
has_related_synonym: EC 2.7.1.151 inhibitor
has_related_synonym: EC 2.7.1.151 inhibitors
has_related_synonym: IP3/IP4 6-/3-kinase inhibitor
has_related_synonym: IP3/IP4 6-/3-kinase inhibitors
has_related_synonym: IP3/IP4 dual-specificity 6-/3-kinase inhibitor
has_related_synonym: IP3/IP4 dual-specificity 6-/3-kinase inhibitors
has_related_synonym: IpK2 inhibitor
has_related_synonym: IpK2 inhibitors
has_related_synonym: IpmK inhibitor
has_related_synonym: IpmK inhibitors
has_related_synonym: inositol polyphosphate 6-/3-/5-kinase inhibitor
has_related_synonym: inositol polyphosphate 6-/3-/5-kinase inhibitors
has_related_synonym: inositol-polyphosphate multikinase (EC 2.7.1.151) inhibitor
has_related_synonym: inositol-polyphosphate multikinase (EC 2.7.1.151) inhibitors
has_related_synonym: inositol-polyphosphate multikinase inhibitor
has_related_synonym: inositol-polyphosphate multikinase inhibitors
id: CHEBI:84802
in subset: 3 STAR

EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: Any EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with a phosphate group as acceptor (EC 2.7.4.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitors
has_related_synonym: EC 2.7.4.* inhibitor
has_related_synonym: EC 2.7.4.* inhibitors
has_related_synonym: phosphotransferases with a phosphate group as acceptor (EC 2.7.4.*) inhibitor
has_related_synonym: phosphotransferases with a phosphate group as acceptor (EC 2.7.4.*) inhibitors
id: CHEBI:84803
in subset: 3 STAR

EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor
type: Class
subclass of: EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitor
textual definition: Any EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitor that interferes with the action of nucleoside-diphosphate kinase (EC 2.7.4.6).
imported from: chebi.owl
has cross-reference: Wikipedia:Nucleoside-diphosphate_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:nucleoside-diphosphate phosphotransferase inhibitor
has_related_synonym: ATP:nucleoside-diphosphate phosphotransferase inhibitors
has_related_synonym: EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitors
has_related_synonym: EC 2.7.4.6 inhibitor
has_related_synonym: EC 2.7.4.6 inhibitors
has_related_synonym: UDP kinase inhibitor
has_related_synonym: UDP kinase inhibitors
has_related_synonym: nucleoside 5'-diphosphate kinase inhibitor
has_related_synonym: nucleoside 5'-diphosphate kinase inhibitors
has_related_synonym: nucleoside diphosphate (UDP) kinase inhibitor
has_related_synonym: nucleoside diphosphate (UDP) kinase inhibitors
has_related_synonym: nucleoside diphosphokinase inhibitor
has_related_synonym: nucleoside diphosphokinase inhibitors
has_related_synonym: nucleoside-diphosphate kinase (EC 2.7.4.6) inhibitor
has_related_synonym: nucleoside-diphosphate kinase (EC 2.7.4.6) inhibitors
has_related_synonym: nucleoside-diphosphate kinase inhibitor
has_related_synonym: nucleoside-diphosphate kinase inhibitors
has_related_synonym: nucleotide phosphate kinase inhibitor
has_related_synonym: nucleotide phosphate kinase inhibitors
has_related_synonym: uridine diphosphate kinase inhibitor
has_related_synonym: uridine diphosphate kinase inhibitors
id: CHEBI:84804
in subset: 3 STAR

EC 2.6.1.16 (glutamine--fructose-6-phosphate transaminase (isomerizing)) inhibitor
type: Class
subclass of: EC 2.6.1.* (transaminase) inhibitor
textual definition: An EC 2.6.1.* (transaminase) inhibitor that interferes with the action of glutamine--fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.19).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: D-fructose-6-phosphate amidotransferase inhibitor
has_related_synonym: D-fructose-6-phosphate amidotransferase inhibitors
has_related_synonym: EC 2.6.1.16 (glutamine--fructose-6-phosphate transaminase (isomerizing)) inhibitors
has_related_synonym: EC 2.6.1.16 inhibitor
has_related_synonym: EC 2.6.1.16 inhibitors
has_related_synonym: GlcN6P synthase inhibitor
has_related_synonym: GlcN6P synthase inhibitors
has_related_synonym: L-glutamine-D-fructose-6-phosphate amidotransferase inhibitor
has_related_synonym: L-glutamine-D-fructose-6-phosphate amidotransferase inhibitors
has_related_synonym: L-glutamine:D-fructose-6-phosphate isomerase (deaminating) inhibitor
has_related_synonym: L-glutamine:D-fructose-6-phosphate isomerase (deaminating) inhibitors
has_related_synonym: glucosamine 6-phosphate synthase inhibitor
has_related_synonym: glucosamine 6-phosphate synthase inhibitors
has_related_synonym: glucosamine-6-phosphate isomerase (glutamine-forming) inhibitor
has_related_synonym: glucosamine-6-phosphate isomerase (glutamine-forming) inhibitors
has_related_synonym: glucosamine-6-phosphate synthase inhibitor
has_related_synonym: glucosamine-6-phosphate synthase inhibitors
has_related_synonym: glucosaminephosphate isomerase inhibitor
has_related_synonym: glucosaminephosphate isomerase inhibitors
has_related_synonym: hexosephosphate aminotransferase inhibitor
has_related_synonym: hexosephosphate aminotransferase inhibitors
id: CHEBI:85011
in subset: 3 STAR

thrombopoietin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates the thrombopoietin receptor [myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110)].
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: TPO receptor agonist
has_related_synonym: TPO receptor agonists
has_related_synonym: thrombopoietin receptor agonists
id: CHEBI:85012
in subset: 3 STAR

skin lightening agent
type: Class
subclass of: cosmetic
textual definition: Any cosmetic used to lighten the colour of skin by reducing the concentration of melanin.
imported from: chebi.owl
has cross-reference: PMID:21265866
has cross-reference: PMID:22132817
has cross-reference: PMID:22314516
has cross-reference: PMID:23891889
has cross-reference: PMID:23974587
has cross-reference: PMID:25535470
has cross-reference: PMID:25574195
has cross-reference: PMID:25643794
has cross-reference: Wikipedia:Skin_whitening
has_obo_namespace: chebi_ontology
has_related_synonym: melanogenesis inhibitor
has_related_synonym: melanogenesis inhibitors
has_related_synonym: skin bleaching agent
has_related_synonym: skin bleaching agents
has_related_synonym: skin depigmenting agent
has_related_synonym: skin depigmenting agents
has_related_synonym: skin lightening agents
has_related_synonym: skin whitening agent
has_related_synonym: skin whitening agents
id: CHEBI:85046
in subset: 3 STAR

EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor
type: Class
subclass of: EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor
textual definition: An EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.10.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitors
has_related_synonym: EC 1.10.3.* inhibitor
has_related_synonym: EC 1.10.3.* inhibitors
id: CHEBI:85048
in subset: 3 STAR

EC 1.10.3.1 (catechol oxidase) inhibitor
type: Class
subclass of: EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor
textual definition: Any EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor that interferes with the action of catechol oxidase (EC 1.10.3.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Catechol_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2-benzenediol:oxygen oxidoreductase inhibitor
has_related_synonym: 1,2-benzenediol:oxygen oxidoreductase inhibitors
has_related_synonym: Dopa oxidase inhibitor
has_related_synonym: Dopa oxidase inhibitors
has_related_synonym: EC 1.10.3.1 (catechol oxidase) inhibitors
has_related_synonym: EC 1.10.3.1 inhibitor
has_related_synonym: EC 1.10.3.1 inhibitors
has_related_synonym: catechol oxidase (EC 1.10.3.1) inhibitor
has_related_synonym: catechol oxidase (EC 1.10.3.1) inhibitors
has_related_synonym: catechol oxidase inhibitor
has_related_synonym: catechol oxidase inhibitors
has_related_synonym: catecholase inhibitor
has_related_synonym: catecholase inhibitors
has_related_synonym: diphenol oxidase inhibitor
has_related_synonym: diphenol oxidase inhibitors
has_related_synonym: o-diphenol oxidoreductase inhibitor
has_related_synonym: o-diphenol oxidoreductase inhibitors
has_related_synonym: o-diphenol:oxygen oxidoreductase inhibitor
has_related_synonym: o-diphenol:oxygen oxidoreductase inhibitors
has_related_synonym: o-diphenolase inhibitor
has_related_synonym: o-diphenolase inhibitors
has_related_synonym: phenolase inhibitor
has_related_synonym: phenolase inhibitors
has_related_synonym: polyphenol oxidase inhibitor
has_related_synonym: polyphenol oxidase inhibitors
has_related_synonym: pyrocatechol oxidase inhibitor
has_related_synonym: pyrocatechol oxidase inhibitors
has_related_synonym: tyrosinase inhibitor
has_related_synonym: tyrosinase inhibitors
id: CHEBI:85049
in subset: 3 STAR

EC 1.10.3.2 (laccase) inhibitor
type: Class
subclass of: EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor
textual definition: Any EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor that interferes with the action of laccase (EC 1.10.3.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Laccase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.10.3.2 (laccase) inhibitors
has_related_synonym: EC 1.10.3.2 inhibitor
has_related_synonym: EC 1.10.3.2 inhibitors
has_related_synonym: benzenediol:oxygen oxidoreductase inhibitor
has_related_synonym: benzenediol:oxygen oxidoreductase inhibitors
has_related_synonym: laccase (EC 1.10.3.2) inhibitor
has_related_synonym: laccase (EC 1.10.3.2) inhibitors
has_related_synonym: laccase inhibitor
has_related_synonym: laccase inhibitors
has_related_synonym: p-diphenol oxidase inhibitor
has_related_synonym: p-diphenol oxidase inhibitors
has_related_synonym: urishiol oxidase inhibitor
has_related_synonym: urishiol oxidase inhibitors
has_related_synonym: urushiol oxidase inhibitor
has_related_synonym: urushiol oxidase inhibitors
id: CHEBI:85050
in subset: 3 STAR

EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor
type: Class
subclass of: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
textual definition: Any EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor that interferes with the action of quercetin 2,3-dioxygenase (EC 1.13.1.24).
imported from: chebi.owl
has cross-reference: Wikipedia:Quercetin_2,3-dioxygenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitors
has_related_synonym: EC 1.13.11.24 inhibitor
has_related_synonym: EC 1.13.11.24 inhibitors
has_related_synonym: flavonol 2,4-oxygenase inhibitor
has_related_synonym: flavonol 2,4-oxygenase inhibitors
has_related_synonym: quercetin 2,3-dioxygenase (EC 1.13.11.24) inhibitor
has_related_synonym: quercetin 2,3-dioxygenase (EC 1.13.11.24) inhibitors
has_related_synonym: quercetin 2,3-dioxygenase inhibitor
has_related_synonym: quercetin 2,3-dioxygenase inhibitors
has_related_synonym: quercetin:oxygen 2,3-oxidoreductase (decyclising) inhibitor
has_related_synonym: quercetin:oxygen 2,3-oxidoreductase (decyclising) inhibitors
has_related_synonym: quercetin:oxygen 2,3-oxidoreductase (decyclizing) inhibitor
has_related_synonym: quercetin:oxygen 2,3-oxidoreductase (decyclizing) inhibitors
has_related_synonym: quercetin:oxygen 2,3-oxidoreductase (ring-opening) inhibitor
has_related_synonym: quercetin:oxygen 2,3-oxidoreductase (ring-opening) inhibitors
has_related_synonym: quercetinase inhibitor
has_related_synonym: quercetinase inhibitors
id: CHEBI:85051
in subset: 3 STAR

EC 1.4.3.3 (D-amino-acid oxidase) inhibitor
type: Class
subclass of: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor
textual definition: Any EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of D-amino-acid oxidase (EC 1.4.3.3).
imported from: chebi.owl
has cross-reference: Wikipedia:D-amino_acid_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: D-amino-acid oxidase (EC 1.4.3.3) inhibitor
has_related_synonym: D-amino-acid oxidase (EC 1.4.3.3) inhibitors
has_related_synonym: D-amino-acid oxidase inhibitor
has_related_synonym: D-amino-acid oxidase inhibitors
has_related_synonym: D-amino-acid:oxygen oxidoreductase (deaminating) inhibitor
has_related_synonym: D-amino-acid:oxygen oxidoreductase (deaminating) inhibitors
has_related_synonym: EC 1.4.3.3 (D-amino-acid oxidase) inhibitors
has_related_synonym: EC 1.4.3.3 inhibitor
has_related_synonym: EC 1.4.3.3 inhibitors
has_related_synonym: L-amino acid:O2 oxidoreductase inhibitor
has_related_synonym: L-amino acid:O2 oxidoreductase inhibitors
has_related_synonym: new yellow enzyme inhibitor
has_related_synonym: new yellow enzyme inhibitors
has_related_synonym: ophio-amino-acid oxidase inhibitor
has_related_synonym: ophio-amino-acid oxidase inhibitors
id: CHEBI:85052
in subset: 3 STAR

EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator
type: Class
subclass of: enzyme activator
textual definition: Any compound that binds to and activates the enzyme [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.11.31).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activator
has_related_synonym: 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activators
has_related_synonym: 3-hydroxy-3-methylglutaryl-CoA reductase kinase activator
has_related_synonym: 3-hydroxy-3-methylglutaryl-CoA reductase kinase activators
has_related_synonym: AMP-activated protein kinase activator
has_related_synonym: AMP-activated protein kinase activators
has_related_synonym: AMPK activator
has_related_synonym: AMPK activators
has_related_synonym: ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase activator
has_related_synonym: ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase activators
has_related_synonym: EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) activator
has_related_synonym: EC 2.7.11.31 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase) activators
has_related_synonym: EC 2.7.11.31 activator
has_related_synonym: EC 2.7.11.31 activators
has_related_synonym: EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activators
has_related_synonym: HMG-CoA reductase kinase activator
has_related_synonym: HMG-CoA reductase kinase activators
has_related_synonym: STK29 activator
has_related_synonym: STK29 activators
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activator
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activators
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase activator
has_related_synonym: [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase activators
has_related_synonym: beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activator
has_related_synonym: beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activators
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activator
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activators
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase activator
has_related_synonym: hydroxymethylglutaryl coenzyme A reductase kinase activators
has_related_synonym: hydroxymethylglutaryl-CoA reductase kinase activator
has_related_synonym: hydroxymethylglutaryl-CoA reductase kinase activators
has_related_synonym: reductase kinase activator
has_related_synonym: reductase kinase activators
id: CHEBI:85053
in subset: 3 STAR

EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cAMP-dependent protein kinase (EC 2.7.11.11).
imported from: chebi.owl
has cross-reference: Wikipedia:Protein_kinase_A
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:protein phosphotransferase (cAMP-dependent) inhibitor
has_related_synonym: ATP:protein phosphotransferase (cAMP-dependent) inhibitors
has_related_synonym: EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitors
has_related_synonym: EC 2.7.11.11 inhibitor
has_related_synonym: EC 2.7.11.11 inhibitors
has_related_synonym: PKA C inhibitor
has_related_synonym: PKA C inhibitors
has_related_synonym: PKA inhibitor
has_related_synonym: PKA inhibitors
has_related_synonym: STK22 inhibitor inhibitor
has_related_synonym: STK22 inhibitors inhibitors
has_related_synonym: cAMP-dependent protein kinase (EC 2.7.11.11) inhibitor
has_related_synonym: cAMP-dependent protein kinase (EC 2.7.11.11) inhibitors
has_related_synonym: cAMP-dependent protein kinase inhibitor
has_related_synonym: cAMP-dependent protein kinase inhibitors
has_related_synonym: protein kinase A inhibitor
has_related_synonym: protein kinase A inhibitors
id: CHEBI:85094
in subset: 3 STAR

EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cGMP-dependent protein kinase (EC 2.7.11.12).
imported from: chebi.owl
has cross-reference: Wikipedia:CGMP-dependent_protein_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: 3':5'-cyclic GMP-dependent protein kinase inhibitor
has_related_synonym: 3':5'-cyclic GMP-dependent protein kinase inhibitors
has_related_synonym: ATP:protein phosphotransferase (cGMP-dependent) inhibitor
has_related_synonym: ATP:protein phosphotransferase (cGMP-dependent) inhibitors
has_related_synonym: EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitors
has_related_synonym: EC 2.7.11.12 inhibitor
has_related_synonym: EC 2.7.11.12 inhibitors
has_related_synonym: PKG 1alpha inhibitor
has_related_synonym: PKG 1alpha inhibitors
has_related_synonym: PKG 1beta inhibitor
has_related_synonym: PKG 1beta inhibitors
has_related_synonym: PKG II inhibitor
has_related_synonym: PKG II inhibitors
has_related_synonym: PKG inhibitor
has_related_synonym: PKG inhibitors
has_related_synonym: STK23 inhibitor
has_related_synonym: STK23 inhibitors
has_related_synonym: cGMP-dependent protein kinase (EC 2.7.11.12) inhibitor
has_related_synonym: cGMP-dependent protein kinase (EC 2.7.11.12) inhibitors
has_related_synonym: cGMP-dependent protein kinase Ibeta inhibitor
has_related_synonym: cGMP-dependent protein kinase Ibeta inhibitors
has_related_synonym: cGMP-dependent protein kinase inhibitor
has_related_synonym: cGMP-dependent protein kinase inhibitors
has_related_synonym: guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitor
has_related_synonym: guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitors
id: CHEBI:85113
in subset: 3 STAR

nonnucleoside hepatitis C virus polymerase inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of nonnucleoside hepatitis C virus polymerase.
imported from: chebi.owl
has cross-reference: Wikipedia:NS5B
has_obo_namespace: chebi_ontology
has_related_synonym: NS5B inhibitor
has_related_synonym: NS5B inhibitors
has_related_synonym: nonnucleoside hepatitis C virus polymerase inhibitors
has_related_synonym: nonstructural protein 5B inhibitor
has_related_synonym: nonstructural protein 5B inhibitors
id: CHEBI:85180
in subset: 3 STAR

hepatitis C virus nonstructural protein 5A inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of hepatitis C virus nonstructural protein 5A.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: NS5A inhibitor
has_related_synonym: NS5A inhibitors
has_related_synonym: hepatitis C virus nonstructural protein 5A inhibitors
has_related_synonym: nonstructural protein 5A inhibitor
has_related_synonym: nonstructural protein 5A inhibitors
id: CHEBI:85185
in subset: 3 STAR

human blood serum metabolite
type: Class
subclass of: human metabolite
textual definition: Any metabolite (endogenous or exogenous) found in human blood serum samples.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: human blood serum metabolites
id: CHEBI:85234
in subset: 3 STAR

GABA reuptake inhibitor
type: Class
subclass of: neurotransmitter agent
textual definition: A compound that inhibits the re-uptake of the neurotransmitter GABA from the synapse into the pre-synaptic neuron, so increasing the extracellular concentrations of the neurotransmitter and hence increasing neurotransmission.
imported from: chebi.owl
has cross-reference: Wikipedia:GABA_reuptake_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: GABA re-uptake inhibitor
has_related_synonym: GABA re-uptake inhibitors
has_related_synonym: GABA reuptake inhibitors
has_related_synonym: gamma-aminobutyric acid re-uptake inhibitor
has_related_synonym: gamma-aminobutyric acid re-uptake inhibitors
has_related_synonym: gamma-aminobutyric acid reuptake inhibitor
has_related_synonym: gamma-aminobutyric acid reuptake inhibitors
id: CHEBI:85384
in subset: 3 STAR

glycine transporter 2 inhibitor
type: Class
subclass of: glycine transporter inhibitor
textual definition: Any glycine transporter inhibitor that interferes with the action of glycine 2 transporters.
imported from: chebi.owl
has cross-reference: Wikipedia:Glycine_transporter_2
has_obo_namespace: chebi_ontology
has_related_synonym: GlyT2 inhibitor
has_related_synonym: GlyT2 inhibitors
has_related_synonym: glycine transporter 2 inhibitors
id: CHEBI:85424
in subset: 3 STAR

glycine transporter inhibitor
type: Class
subclass of: inhibitor
textual definition: Any substance that inhibits the action of glycine transporters.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glycine transporter inhibitors
id: CHEBI:85425
in subset: 3 STAR

thromboxane A2 antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates thromboxane A2 receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: TXA2/PGH2 antagonist
has_related_synonym: TXA2/PGH2 antagonists
has_related_synonym: TXA2/PGH2 receptor antagonist
has_related_synonym: TXA2/PGH2 receptor antagonists
has_related_synonym: thromboxane A2 antagonists
has_related_synonym: thromboxane A2 receptor antagonist
has_related_synonym: thromboxane A2 receptor antagonists
id: CHEBI:85540
in subset: 3 STAR

EC 2.5.1.31 {ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]} inhibitor
type: Class
subclass of: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
textual definition: An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific].
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 8 isopentenyl units) inhibitor
has_related_synonym: (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 8 isopentenyl units) inhibitors
has_related_synonym: EC 2.5.1.31 inhibitor
has_related_synonym: EC 2.5.1.31 inhibitors
has_related_synonym: EC 2.5.1.31 {ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]} inhibitors
has_related_synonym: UPP synthetase inhibitor
has_related_synonym: UPP synthetase inhibitors
has_related_synonym: bactoprenyl-diphosphate synthase inhibitor
has_related_synonym: bactoprenyl-diphosphate synthase inhibitors
has_related_synonym: ditrans,polycis-undecaprenyl-diphosphate synthase inhibitor
has_related_synonym: ditrans,polycis-undecaprenyl-diphosphate synthase inhibitors
has_related_synonym: ditrans,polycis-undecaprenylcistransferase inhibitor
has_related_synonym: ditrans,polycis-undecaprenylcistransferase inhibitors
has_related_synonym: undecaprenyl diphosphate synthetase inhibitor
has_related_synonym: undecaprenyl diphosphate synthetase inhibitors
has_related_synonym: undecaprenyl pyrophosphate synthase inhibitor
has_related_synonym: undecaprenyl pyrophosphate synthase inhibitors
has_related_synonym: undecaprenyl pyrophosphate synthetase inhibitor
has_related_synonym: undecaprenyl pyrophosphate synthetase inhibitors
has_related_synonym: undecaprenyl-diphosphate synthase inhibitor
has_related_synonym: undecaprenyl-diphosphate synthase inhibitors
id: CHEBI:85618
in subset: 3 STAR

EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitor
type: Class
subclass of: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
textual definition: Any EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor that interferes with the action any such enzyme that has NAD(+) or NADP(+) as acceptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group with NAD(+) or NADP(+) as acceptor) inhibitor
has_related_synonym: EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group with NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitors
has_related_synonym: EC 1.4.1.* inhibitor
has_related_synonym: EC 1.4.1.* inhibitors
id: CHEBI:86009
in subset: 3 STAR

EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitor
type: Class
subclass of: EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitor
textual definition: An EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of glutamate dehydrogenase [NAD(P)(+)] (EC 1.4.1.3).
imported from: chebi.owl
has cross-reference: Wikipedia:Glutamate_dehydrogenase_1
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.4.1.3 inhibitor
has_related_synonym: EC 1.4.1.3 inhibitors
has_related_synonym: EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitors
has_related_synonym: L-glutamate:NAD(P)(+) oxidoreductase (deaminating) inhibitor
has_related_synonym: L-glutamate:NAD(P)(+) oxidoreductase (deaminating) inhibitors
has_related_synonym: glutamate dehydrogenase [NAD(P)(+)] (EC 1.4.1.3) inhibitor
has_related_synonym: glutamate dehydrogenase [NAD(P)(+)] (EC 1.4.1.3) inhibitors
has_related_synonym: glutamate dehydrogenase [NAD(P)(+)] inhibitor
has_related_synonym: glutamate dehydrogenase [NAD(P)(+)] inhibitors
has_related_synonym: glutamic dehydrogenase inhibitor
has_related_synonym: glutamic dehydrogenase inhibitors
id: CHEBI:86010
in subset: 3 STAR

liver X receptor agonist
type: Class
subclass of: agonist
textual definition: Any compound that acts as an agonist towards the liver X receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:Liver_X_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: LXR agonist
has_related_synonym: LXR agonists
has_related_synonym: liver X receptor agonists
id: CHEBI:86029
in subset: 3 STAR

rat metabolite
type: Class
subclass of: mammalian metabolite
textual definition: Any mammalian metabolite produced during a metabolic reaction in rat (Rattus norvegicus).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Rattus norvegicus metabolite
has_related_synonym: Rattus norvegicus metabolites
has_related_synonym: rat metabolites
id: CHEBI:86264
in subset: 3 STAR

antifungal drug
type: Class
subclass of: drug
subclass of: antiinfective agent
subclass of: antifungal agent
textual definition: Any antifungal agent used to prevent or treat fungal infections in humans or animals.
imported from: chebi.owl
has cross-reference: Wikipedia:Antifungal
has_obo_namespace: chebi_ontology
has_related_synonym: anti-fungal drug
has_related_synonym: anti-fungal drugs
has_related_synonym: anti-fungal medication
has_related_synonym: anti-fungal medications
has_related_synonym: antifungal drugs
has_related_synonym: antifungal medication
has_related_synonym: antifungal medications
has_related_synonym: pharmaceutical fungicide
has_related_synonym: pharmaceutical fungicides
id: CHEBI:86327
in subset: 3 STAR

antifungal agrochemical
type: Class
subclass of: fungicide
subclass of: pesticide
subclass of: agrochemical
textual definition: Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: agrichemical fungicide
has_related_synonym: agrichemical fungicides
has_related_synonym: agrochemical fungicide
has_related_synonym: agrochemical fungicides
has_related_synonym: anti-fungal agrichemical
has_related_synonym: anti-fungal agrichemicals
has_related_synonym: anti-fungal agrochemical
has_related_synonym: anti-fungal agrochemicals
has_related_synonym: antifungal agrichemical
has_related_synonym: antifungal agrichemicals
has_related_synonym: antifungal agrochemicals
id: CHEBI:86328
in subset: 3 STAR

EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor
type: Class
subclass of: EC 5.3.* (intramolecular oxidoreductase) inhibitor
textual definition: An EC 5.3.* (intramolecular oxidoreductase) inhibitor that inhibits the action of any such enzyme that transposes C=C bonds (EC 5.3.3.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitors
has_related_synonym: EC 5.3.3.* inhibitor
has_related_synonym: EC 5.3.3.* inhibitors
has_related_synonym: intramolecular oxidase transposing C=C bonds inhibitor (EC 5.3.3.*) inhibitor
has_related_synonym: intramolecular oxidase transposing C=C bonds inhibitor (EC 5.3.3.*) inhibitors
id: CHEBI:86383
in subset: 3 STAR

EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor
type: Class
subclass of: EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor
textual definition: An EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor that interferes with the action of a cholestenol Delta-isomerase (EC 5.3.3.5).
imported from: chebi.owl
has cross-reference: Wikipedia:Cholestenol_Delta-isomerase
has_obo_namespace: chebi_ontology
has_related_synonym: Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitor
has_related_synonym: Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitors
has_related_synonym: EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitors
has_related_synonym: EC 5.3.3.5 inhibitor
has_related_synonym: EC 5.3.3.5 inhibitors
has_related_synonym: cholestenol Delta-isomerase (EC 5.3.3.5) inhibitor
has_related_synonym: cholestenol Delta-isomerase (EC 5.3.3.5) inhibitors
id: CHEBI:86385
in subset: 3 STAR

EC 1.14.13.78 (ent-kaurene oxidase) inhibitor
type: Class
subclass of: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of ent-kaurene oxidase (E.C. 1.14.13.78).
imported from: chebi.owl
has cross-reference: Wikipedia:Ent-kaurene_oxidase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.13.78 (ent-kaurene oxidase) inhibitors
has_related_synonym: EC 1.14.13.78 inhibitor
has_related_synonym: EC 1.14.13.78 inhibitors
has_related_synonym: ent-kaurene oxidase (EC 1.14.13.78) inhibitor
has_related_synonym: ent-kaurene oxidase (EC 1.14.13.78) inhibitors
id: CHEBI:86430
in subset: 3 STAR

EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor
type: Class
subclass of: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
textual definition: An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase).
imported from: chebi.owl
has cross-reference: Wikipedia:CYP3A4
has_obo_namespace: chebi_ontology
has_related_synonym: CYP3A4 inhibitor
has_related_synonym: CYP3A4 inhibitors
has_related_synonym: CYP4A21 inhibitor
has_related_synonym: CYP4A21 inhibitors
has_related_synonym: EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitors
has_related_synonym: EC 1.14.13.97 inhibitor
has_related_synonym: EC 1.14.13.97 inhibitors
has_related_synonym: cytochrome P450 3A4 inhibitor
has_related_synonym: cytochrome P450 3A4 inhibitors
has_related_synonym: taurochenodeoxycholate 6alpha-hydroxylase inhibitor
has_related_synonym: taurochenodeoxycholate 6alpha-hydroxylase inhibitors
has_related_synonym: taurochenodeoxycholate 6alpha-monooxygenase inhibitor
has_related_synonym: taurochenodeoxycholate 6alpha-monooxygenase inhibitors
has_related_synonym: taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) inhibitor
has_related_synonym: taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) inhibitors
id: CHEBI:86501
in subset: 3 STAR

EC 3.4.21.92 (endopeptidase Clp) inhibitor
type: Class
subclass of: EC 3.4.21.* (serine endopeptidase) inhibitor
textual definition: Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of endopeptidase Clp (EC 3.4.21.92).
imported from: chebi.owl
has cross-reference: Wikipedia:ATP-dependent_Clp_protease_proteolytic_subunit
has_obo_namespace: chebi_ontology
has_related_synonym: ATP-dependent Clp protease inhibitor
has_related_synonym: ATP-dependent Clp protease inhibitors
has_related_synonym: Clp protease inhibitor
has_related_synonym: Clp protease inhibitors
has_related_synonym: ClpP inhibitor
has_related_synonym: ClpP inhibitors
has_related_synonym: EC 3.4.21.92 (endopeptidase Clp) inhibitors
has_related_synonym: EC 3.4.21.92 inhibitor
has_related_synonym: EC 3.4.21.92 inhibitors
has_related_synonym: caseinolytic protease inhibitor
has_related_synonym: caseinolytic protease inhibitors
has_related_synonym: endopeptidase Ti inhibitor
has_related_synonym: endopeptidase Ti inhibitors
has_related_synonym: protease Ti inhibitor
has_related_synonym: protease Ti inhibitors
id: CHEBI:86966
in subset: 3 STAR

STAT3 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: An inhibitor of signal transducer and activator of transcription 3 (STAT3)
imported from: chebi.owl
has cross-reference: Wikipedia:STAT3
has_obo_namespace: chebi_ontology
has_related_synonym: STAT3 inhibitors
has_related_synonym: signal transducer and activator of transcription 3 inhibitor
has_related_synonym: signal transducer and activator of transcription 3 inhibitors
id: CHEBI:87183
in subset: 3 STAR

Smad3 inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor of the SMAD3 protein.
imported from: chebi.owl
has cross-reference: Wikipedia:Mothers_against_decapentaplegic_homolog_3
alternative_term: Smad3 inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: Mothers against decapentaplegic homolog 3 inhibitors
has_related_synonym: Mothers against decapentaplegic homologue 3 inhibitor
has_related_synonym: Mothers against decapentaplegic homologue 3 inhibitors
has_related_synonym: SMAD family member 3 inhibitor
has_related_synonym: SMAD family member 3 inhibitors
has_related_synonym: SMAD3 inhibitors
has_related_synonym: Smad3 inhibitors
has_related_synonym: mothers against decapentaplegic homolog 3 inhibitor
id: CHEBI:87588
in subset: 3 STAR

signal transducer and activator of transcription 5 protein inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of signal transducer and activator of transcription 5 protein
imported from: chebi.owl
has cross-reference: Wikipedia:STAT5
has_obo_namespace: chebi_ontology
has_related_synonym: STAT5 inhibitor
has_related_synonym: STAT5 inhibitors
has_related_synonym: signal transducer and activator of transcription 5 protein inhibitors
id: CHEBI:87786
in subset: 3 STAR

cyanotoxin
type: Class
subclass of: toxin
subclass of: bacterial metabolite
textual definition: Any toxin produced by cyanobacteria (blue-green algae).
imported from: chebi.owl
has cross-reference: Wikipedia:Cyanotoxin
has_obo_namespace: chebi_ontology
has_related_synonym: cyanotoxins
id: CHEBI:88048
in subset: 3 STAR

drug allergen
type: Class
subclass of: drug
subclass of: allergen
textual definition: Any drug which causes the onset of an allergic reaction.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: allergenic drug
id: CHEBI:88188
in subset: 3 STAR

potassium ionophore
type: Class
subclass of: ionophore
textual definition: Any ionophore capable of transportation of potassium ions across membranes.
imported from: chebi.owl
has cross-reference: PMID:11841304
has_obo_namespace: chebi_ontology
has_related_synonym: potassium ionophores
id: CHEBI:88227
in subset: 3 STAR

autophagy inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
imported from: chebi.owl
has cross-reference: PMID:24830781
has cross-reference: PMID:25727221
has cross-reference: PMID:25793774
has cross-reference: PMID:25896709
has cross-reference: Wikipedia:Autophagy
has_obo_namespace: chebi_ontology
has_related_synonym: autophagocytosis inhibitor
has_related_synonym: autophagocytosis inhibitors
has_related_synonym: autophagy inhibitors
id: CHEBI:88230
in subset: 3 STAR

EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor
type: Class
subclass of: EC 2.7.* (P-containing group transferase) inhibitor
textual definition: An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of duals specificity kinases acting on Ser/Thr and Tyr residues.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitors
has_related_synonym: EC 2.7.12.* inhibitor
has_related_synonym: EC 2.7.12.* inhibitors
has_related_synonym: inhibitor of dual-specificity kinases (those acting on Ser/Thr and Tyr residues) (EC 2.7.12.*)
has_related_synonym: inhibitors of dual-specificity kinases (those acting on Ser/Thr and Tyr residues) (EC 2.7.12.*)
id: CHEBI:88285
in subset: 3 STAR

EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor
type: Class
subclass of: EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor
textual definition: An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of mitogen-activated protein kinase kinase (EC 2.7.12.2).
imported from: chebi.owl
has cross-reference: Wikipedia:Mitogen-activated_protein_kinase_kinase
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:protein phosphotransferase (MAPKKK-activated) inhibitor
has_related_synonym: ATP:protein phosphotransferase (MAPKKK-activated) inhibitors
has_related_synonym: EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitors
has_related_synonym: EC 2.7.12.2 inhibitor
has_related_synonym: EC 2.7.12.2 inhibitors
has_related_synonym: MAP kinase kinase 4 inhibitor
has_related_synonym: MAP kinase kinase 4 inhibitors
has_related_synonym: MAP kinase kinase 7 inhibitor
has_related_synonym: MAP kinase kinase 7 inhibitors
has_related_synonym: MAP kinase kinase inhibitor
has_related_synonym: MAP kinase kinase inhibitors
has_related_synonym: MAP kinase or ERK kinase inhibitor
has_related_synonym: MAP kinase or ERK kinase inhibitors
has_related_synonym: MAP2K inhibitor
has_related_synonym: MAP2K inhibitors
has_related_synonym: MAPKK inhibitor
has_related_synonym: MAPKK inhibitors
has_related_synonym: MAPKK1 inhibitor
has_related_synonym: MAPKK1 inhibitors
has_related_synonym: MEK inhibitor
has_related_synonym: MEK inhibitors
has_related_synonym: MEK1 inhibitor
has_related_synonym: MEK1 inhibitors
has_related_synonym: MEK2 inhibitor
has_related_synonym: MEK2 inhibitors
has_related_synonym: MKK inhibitor
has_related_synonym: MKK inhibitors
has_related_synonym: MKK2 inhibitor
has_related_synonym: MKK2 inhibitors
has_related_synonym: MKK4 inhibitor
has_related_synonym: MKK4 inhibitors
has_related_synonym: MKK6 inhibitor
has_related_synonym: MKK6 inhibitors
has_related_synonym: MKK7 inhibitor
has_related_synonym: MKK7 inhibitors
has_related_synonym: STK27 inhibitor
has_related_synonym: STK27 inhibitors
has_related_synonym: mitogen-activated protein kinase kinase (EC 2.7.12.2) inhibitor
has_related_synonym: mitogen-activated protein kinase kinase (EC 2.7.12.2) inhibitors
has_related_synonym: mitogen-activated protein kinase kinase inhibitor
has_related_synonym: mitogen-activated protein kinase kinase inhibitors
id: CHEBI:88286
in subset: 3 STAR

G-protein-coupled receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at G-protein-coupled receptor.
imported from: chebi.owl
has cross-reference: Wikipedia:G_protein-coupled_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: G-protein-coupled receptor antagonists
has_related_synonym: GPCR antagonist
has_related_synonym: GPCR antagonists
id: CHEBI:88295
in subset: 3 STAR

retinoic acid receptor gamma agonist
type: Class
subclass of: retinoic acid receptor agonist
textual definition: Any retinoic acid receptor (RAR) agonist with specificity for RARgamma.
imported from: chebi.owl
has cross-reference: PMID:11829754
has cross-reference: Wikipedia:Retinoic_acid_receptor_gamma
has_obo_namespace: chebi_ontology
has_related_synonym: NR1B3 agonist
has_related_synonym: NR1B3 agonists
has_related_synonym: RARgamma agonist
has_related_synonym: RARgamma agonists
has_related_synonym: nuclear receptor subfamily 1, group B, member 3 agonist
has_related_synonym: nuclear receptor subfamily 1, group B, member 3 agonists
has_related_synonym: retinoic acid receptor gamma agonists
id: CHEBI:88336
in subset: 3 STAR

alpha-secretase activator
type: Class
subclass of: enzyme activator
textual definition: An activator of alpha-secretase, one of the three endopeptidases that are specific for amyloid protein precursor and which have been identified based upon the region of the amyloid protein precursor which they cleave.
imported from: chebi.owl
has cross-reference: PMID:19655822
has cross-reference: PMID:22202113
has cross-reference: Wikipedia:Alpha_secretase
has_obo_namespace: chebi_ontology
has_related_synonym: alpha-secretase activators
id: CHEBI:88355
in subset: 3 STAR

EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
textual definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170).
imported from: chebi.owl
has cross-reference: Wikipedia:Sterol-4alpha-carboxylate_3-dehydrogenase_(decarboxylating)
has_obo_namespace: chebi_ontology
has_related_synonym: 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitor
has_related_synonym: 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitors
has_related_synonym: 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitor
has_related_synonym: 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitors
has_related_synonym: 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase inhibitor
has_related_synonym: 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase inhibitors
has_related_synonym: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) inhibitor
has_related_synonym: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) inhibitors
has_related_synonym: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitor
has_related_synonym: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitors
has_related_synonym: 3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)(+) 3-oxidoreductase (decarboxylating) inhibitor
has_related_synonym: 3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)(+) 3-oxidoreductase (decarboxylating) inhibitors
has_related_synonym: EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitors
has_related_synonym: EC 1.1.1.170 inhibitor
has_related_synonym: EC 1.1.1.170 inhibitors
has_related_synonym: sterol 4alpha-carboxylic decarboxylase inhibitor
has_related_synonym: sterol 4alpha-carboxylic decarboxylase inhibitors
has_related_synonym: sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitor
has_related_synonym: sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) inhibitors
id: CHEBI:90113
in subset: 3 STAR

c-Jun N-terminal kinase inhibitor
type: Class
subclass of: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
textual definition: An EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor that inhibits the action of c-Jun N-terminal kinase.
imported from: chebi.owl
has cross-reference: Wikipedia:C-Jun_N-terminal_kinases
has_obo_namespace: chebi_ontology
has_related_synonym: JNK inhibitor
has_related_synonym: JNK inhibitors
has_related_synonym: c-Jun N-terminal kinase inhibitors
id: CHEBI:90172
in subset: 3 STAR

EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor
type: Class
subclass of: EC 2.1.1.* (methyltransferases) inhibitor
textual definition: An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37).
imported from: chebi.owl
has cross-reference: Wikipedia:DNMT1
has_obo_namespace: chebi_ontology
has_related_synonym: DNA 5-cytosine methylase inhibitor
has_related_synonym: DNA 5-cytosine methylase inhibitors
has_related_synonym: DNA cytosine c(5) methylase inhibitor
has_related_synonym: DNA cytosine c(5) methylase inhibitors
has_related_synonym: DNA cytosine methylase inhibitor
has_related_synonym: DNA cytosine methylase inhibitors
has_related_synonym: DNA methylase inhibitor
has_related_synonym: DNA methylase inhibitors
has_related_synonym: DNA methyltransferase inhibitor
has_related_synonym: DNA methyltransferase inhibitors
has_related_synonym: DNA transmethylase inhibitor
has_related_synonym: DNA transmethylase inhibitors
has_related_synonym: DNA-cytosine 5-methylase inhibitor
has_related_synonym: DNA-cytosine 5-methylase inhibitors
has_related_synonym: DNA-cytosine methyltransferase inhibitor
has_related_synonym: DNA-cytosine methyltransferase inhibitors
has_related_synonym: EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitors
has_related_synonym: EC 2.1.1.37 inhibitor
has_related_synonym: EC 2.1.1.37 inhibitors
has_related_synonym: EcoRI methylase inhibitor
has_related_synonym: EcoRI methylase inhibitors
has_related_synonym: HpaII methylase inhibitor
has_related_synonym: HpaII methylase inhibitors
has_related_synonym: HpaII' methylase inhibitor
has_related_synonym: HpaII' methylase inhibitors
has_related_synonym: M.BsuRIa inhibitor
has_related_synonym: M.BsuRIa inhibitors
has_related_synonym: M.BsuRIb inhibitor
has_related_synonym: M.BsuRIb inhibitors
has_related_synonym: S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase inhibitor
has_related_synonym: S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase inhibitors
has_related_synonym: Typ II DNA methylase inhibitor
has_related_synonym: Typ II DNA methylase inhibitors
has_related_synonym: cytosine 5-methyltransferase inhibitor
has_related_synonym: cytosine 5-methyltransferase inhibitors
has_related_synonym: cytosine DNA methylase inhibitors
has_related_synonym: cytosine DNA methyltransferase inhibitor
has_related_synonym: cytosine DNA methyltransferase inhibitors
has_related_synonym: cytosine-specific DNA methyltransferase inhibitor
has_related_synonym: cytosine-specific DNA methyltransferase inhibitors
has_related_synonym: deoxyribonucleate methylase inhibitor
has_related_synonym: deoxyribonucleate methylase inhibitors
has_related_synonym: deoxyribonucleate methyltransferase inhibitor
has_related_synonym: deoxyribonucleate methyltransferase inhibitors
has_related_synonym: deoxyribonucleic (cytosine-5-)-methyltransferase inhibitor
has_related_synonym: deoxyribonucleic (cytosine-5-)-methyltransferase inhibitors
has_related_synonym: deoxyribonucleic acid (cytosine-5-)-methyltransferase inhibitor
has_related_synonym: deoxyribonucleic acid (cytosine-5-)-methyltransferase inhibitors
has_related_synonym: deoxyribonucleic acid methylase inhibitor
has_related_synonym: deoxyribonucleic acid methylase inhibitors
has_related_synonym: deoxyribonucleic acid methyltransferase inhibitor
has_related_synonym: deoxyribonucleic acid methyltransferase inhibitors
has_related_synonym: deoxyribonucleic acid modification methylase inhibitor
has_related_synonym: deoxyribonucleic acid modification methylase inhibitors
has_related_synonym: deoxyribonucleic methylase inhibitor
has_related_synonym: deoxyribonucleic methylase inhibitors
has_related_synonym: methylphosphotriester-DNA methyltransferase inhibitor
has_related_synonym: methylphosphotriester-DNA methyltransferase inhibitors
has_related_synonym: modification methylase inhibitor
has_related_synonym: modification methylase inhibitors
has_related_synonym: restriction-modification system inhibitor
has_related_synonym: restriction-modification system inhibitors
has_related_synonym: site-specific DNA-methyltransferase (cytosine-specific) inhibitor
has_related_synonym: site-specific DNA-methyltransferase (cytosine-specific) inhibitors
id: CHEBI:90190
in subset: 3 STAR

c-Met tyrosine kinase inhibitor
type: Class
subclass of: EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
textual definition: An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.
imported from: chebi.owl
has cross-reference: Wikipedia:C-Met_inhibitors
has_obo_namespace: chebi_ontology
has_related_synonym: MET inhibitor
has_related_synonym: MET inhibitors
has_related_synonym: MET proto-oncogene, receptor tyrosine kinase inhibitor
has_related_synonym: MET proto-oncogene, receptor tyrosine kinase inhibitors
has_related_synonym: c-Met inhibitor
has_related_synonym: c-Met inhibitors
has_related_synonym: c-Met tyrosine kinase inhibitors
id: CHEBI:90199
in subset: 3 STAR

EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor
type: Class
subclass of: EC 4.1.1.* (carboxy-lyase) inhibitor
textual definition: Any EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of orotidine-5'-phosphate decarboxylase (EC 4.1.1.23).
imported from: chebi.owl
has cross-reference: Wikipedia:Orotidine_5'-phosphate_decarboxylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitors
has_related_synonym: EC 4.1.1.23 inhibitor
has_related_synonym: EC 4.1.1.23 inhibitors
has_related_synonym: ODCase inhibitor
has_related_synonym: ODCase inhibitors
has_related_synonym: OMP decarboxylase inhibitor
has_related_synonym: OMP decarboxylase inhibitors
has_related_synonym: OMP-DC inhibitor
has_related_synonym: OMP-DC inhibitors
has_related_synonym: OMPdcase inhibitor
has_related_synonym: OMPdcase inhibitors
has_related_synonym: UMP synthase inhibitor
has_related_synonym: UMP synthase inhibitors
has_related_synonym: orotate decarboxylase inhibitor
has_related_synonym: orotate decarboxylase inhibitors
has_related_synonym: orotate monophosphate decarboxylase inhibitor
has_related_synonym: orotate monophosphate decarboxylase inhibitors
has_related_synonym: orotic decarboxylase inhibitor
has_related_synonym: orotic decarboxylase inhibitors
has_related_synonym: orotidine 5'-phosphate decarboxylase inhibitor
has_related_synonym: orotidine 5'-phosphate decarboxylase inhibitors
has_related_synonym: orotidine monophosphate decarboxylase inhibitor
has_related_synonym: orotidine monophosphate decarboxylase inhibitors
has_related_synonym: orotidine phosphate decarboxylase inhibitor
has_related_synonym: orotidine phosphate decarboxylase inhibitors
has_related_synonym: orotidine-5'-monophosphate decarboxylase inhibitor
has_related_synonym: orotidine-5'-monophosphate decarboxylase inhibitors
has_related_synonym: orotidine-5'-phosphate carboxy-lyase (UMP-forming) inhibitor
has_related_synonym: orotidine-5'-phosphate carboxy-lyase (UMP-forming) inhibitors
has_related_synonym: orotidine-5'-phosphate carboxy-lyase inhibitor
has_related_synonym: orotidine-5'-phosphate carboxy-lyase inhibitors
has_related_synonym: orotidine-5'-phosphate decarboxylase (EC 4.1.1.23) inhibitor
has_related_synonym: orotidine-5'-phosphate decarboxylase (EC 4.1.1.23) inhibitors
has_related_synonym: orotidylic acid decarboxylase inhibitor
has_related_synonym: orotidylic acid decarboxylase inhibitors
has_related_synonym: orotidylic decarboxylase inhibitor
has_related_synonym: orotidylic decarboxylase inhibitors
has_related_synonym: orotodylate decarboxylase inhibitor
has_related_synonym: orotodylate decarboxylase inhibitors
has_related_synonym: uridine 5'-monophosphate synthase inhibitor
has_related_synonym: uridine 5'-monophosphate synthase inhibitors
id: CHEBI:90285
in subset: 3 STAR

EC 6.4.1.1 (pyruvate carboxylase) inhibitor
type: Class
subclass of: EC 6.4.1.* (carboxylase) inhibitor
textual definition: An EC 6.4.1.* (carboxylase) inhibitor that interferes with the action of pyruvate carboxylase (EC 6.4.1.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Pyruvate_carboxylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 6.4.1.1 (pyruvate carboxylase) inhibitors
has_related_synonym: EC 6.4.1.1 inhibitor
has_related_synonym: EC 6.4.1.1 inhibitors
has_related_synonym: pyruvate carboxylase (EC 6.4.1.1) inhibitor
has_related_synonym: pyruvate carboxylase (EC 6.4.1.1) inhibitors
has_related_synonym: pyruvate carboxylase inhibitor
has_related_synonym: pyruvate carboxylase inhibitors
has_related_synonym: pyruvate:carbon-dioxide ligase (ADP-forming) inhibitor
has_related_synonym: pyruvate:carbon-dioxide ligase (ADP-forming) inhibitors
has_related_synonym: pyruvic carboxylase inhibitor
has_related_synonym: pyruvic carboxylase inhibitors
id: CHEBI:90318
in subset: 3 STAR

EC 4.6.1.1 (adenylate cyclase) inhibitor
type: Class
subclass of: EC 4.6.* (P-O lyase) inhibitor
textual definition: An EC 4.6.* (P-O lyase) inhibitor that interferes with the action of enzyme adenylate cyclase (EC 4.6.1.1).
imported from: chebi.owl
has cross-reference: PMID:14979
has cross-reference: PMID:24006339
has cross-reference: PMID:25273392
has cross-reference: PMID:25319071
has cross-reference: Wikipedia:Adenylyl_cyclase
has_obo_namespace: chebi_ontology
has_related_synonym: 3',5'-cyclic AMP synthetase inhibitor
has_related_synonym: 3',5'-cyclic AMP synthetase inhibitors
has_related_synonym: ATP diphosphate-lyase (cyclising) inhibitor
has_related_synonym: ATP diphosphate-lyase (cyclising) inhibitors
has_related_synonym: ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitor
has_related_synonym: ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitors
has_related_synonym: ATP diphosphate-lyase (cyclizing) inhibitor
has_related_synonym: ATP diphosphate-lyase (cyclizing) inhibitors
has_related_synonym: ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitor
has_related_synonym: ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitors
has_related_synonym: ATP pyrophosphate-lyase inhibitor
has_related_synonym: ATP pyrophosphate-lyase inhibitors
has_related_synonym: EC 4.6.1.1 (adenylate cyclase) inhibitors
has_related_synonym: EC 4.6.1.1 inhibitor
has_related_synonym: EC 4.6.1.1 inhibitors
has_related_synonym: adenyl cyclase inhibitor
has_related_synonym: adenylate cyclase (EC 4.6.1.1) inhibitor
has_related_synonym: adenylate cyclase (EC 4.6.1.1) inhibitors
has_related_synonym: adenylate cyclase inhibitor
has_related_synonym: adenylate cyclase inhibitors
has_related_synonym: adenylyl cyclase inhibitor
has_related_synonym: adenylyl cyclase inhibitors
has_related_synonym: adenylylcyclase inhibitor
has_related_synonym: adenylylcyclase inhibitors
id: CHEBI:90365
in subset: 3 STAR

histone acetyltransferase activator
type: Class
subclass of: enzyme activator
textual definition: Any compound that binds to and activates the enzyme histone acetyltransferase (EC 2.3.1.48).
imported from: chebi.owl
has cross-reference: Wikipedia:Histone_acetyltransferase
has_obo_namespace: chebi_ontology
has_related_synonym: HAT activator
has_related_synonym: HAT activators
has_related_synonym: histone acetyltransferase activators
id: CHEBI:90374
in subset: 3 STAR

Sir1 inhibitor
type: Class
subclass of: EC 3.5.1.98 (histone deacetylase) inhibitor
textual definition: An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir1.
imported from: chebi.owl
has cross-reference: Wikipedia:Sirtuin_1
has_obo_namespace: chebi_ontology
has_related_synonym: SIRT1 inhibitor
has_related_synonym: SIRT1 inhibitors
has_related_synonym: Sir1 inhibitors
has_related_synonym: sirtuin 1 inhibitor
has_related_synonym: sirtuin 1 inhibitors
id: CHEBI:90375
in subset: 3 STAR

secretagogue
type: Class
subclass of: biochemical role
textual definition: A substance that causes another substance to be secreted.
imported from: chebi.owl
has cross-reference: Wikipedia:Secretagogue
has_obo_namespace: chebi_ontology
has_related_synonym: secretagogues
id: CHEBI:90414
in subset: 3 STAR

insulin secretagogue
type: Class
subclass of: secretagogue
textual definition: A secretagogue that causes the secretion of insulin.
imported from: chebi.owl
has cross-reference: PMID:11235637
has cross-reference: PMID:12365816
has cross-reference: PMID:15989662
has cross-reference: PMID:21185798
has cross-reference: PMID:22563104
has cross-reference: PMID:26229480
has_obo_namespace: chebi_ontology
has_related_synonym: insulin secretagogues
id: CHEBI:90415
in subset: 3 STAR

EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor
type: Class
subclass of: EC 5.3.* (intramolecular oxidoreductase) inhibitor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:90689
in subset: 1 STAR

EC 5.3.1.1 (triose-phosphate isomerase) inhibitor
type: Class
subclass of: EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor
textual definition: Any EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor that interferes with the action of a triose-phosphate isomerase (EC 5.3.1.1).
imported from: chebi.owl
has cross-reference: Wikipedia:Triosephosphate_isomerase
has_obo_namespace: chebi_ontology
has_related_synonym: D-glyceraldehyde-3-phosphate ketol-isomerase inhibitor
has_related_synonym: D-glyceraldehyde-3-phosphate ketol-isomerase inhibitors
has_related_synonym: EC 5.3.1.1 (triose-phosphate isomerase) inhibitors
has_related_synonym: EC 5.3.1.1 inhibitor
has_related_synonym: EC 5.3.1.1 inhibitors
has_related_synonym: phosphotriose isomerase inhibitor
has_related_synonym: phosphotriose isomerase inhibitors
has_related_synonym: triose phosphate mutase inhibitor
has_related_synonym: triose phosphate mutase inhibitors
has_related_synonym: triose phosphoisomerase inhibitor
has_related_synonym: triose phosphoisomerase inhibitors
has_related_synonym: triose-phosphate isomerase (EC 5.3.1.1) inhibitor
has_related_synonym: triose-phosphate isomerase (EC 5.3.1.1) inhibitors
has_related_synonym: triose-phosphate isomerase inhibitor
has_related_synonym: triose-phosphate isomerase inhibitors
has_related_synonym: triosephosphate isomerase inhibitor
has_related_synonym: triosephosphate isomerase inhibitors
has_related_synonym: triosephosphate mutase inhibitor
has_related_synonym: triosephosphate mutase inhibitors
id: CHEBI:90691
in subset: 3 STAR

retinoic acid receptor modulator
type: Class
subclass of: nuclear receptor modulator
textual definition: A nuclear receptor modulator that affects the retinoic acid receptor
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: retinoic acid receptor modulators
id: CHEBI:90708
in subset: 3 STAR

nuclear receptor modulator
type: Class
subclass of: receptor modulator
textual definition: Any receptor modulator acting on nuclear receptors
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nuclear receptor modulators
id: CHEBI:90709
in subset: 3 STAR

receptor modulator
type: Class
subclass of: drug
textual definition: A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.
imported from: chebi.owl
has_alternative_id: CHEBI:189678
has cross-reference: Wikipedia:Receptor_modulator
has_obo_namespace: chebi_ontology
has_related_synonym: receptor modulators
id: CHEBI:90710
in subset: 3 STAR

retinoic acid receptor alpha antagonist
type: Class
subclass of: retinoic acid receptor antagonist
textual definition: A retinoic acid receptor antagonist that antagonises retinoic acid receptor alpha.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: RAR alpha antagonist
has_related_synonym: RAR alpha antagonists
has_related_synonym: RARalpha antagonist
has_related_synonym: RARalpha antagonists
has_related_synonym: retinoic acid receptor alpha antagonists
id: CHEBI:90713
in subset: 3 STAR

retinoic acid receptor antagonist
type: Class
subclass of: antagonist
subclass of: retinoic acid receptor modulator
textual definition: An antagonist that acts at the retinoic acid receptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: RAR antagonist
has_related_synonym: RAR antagonists
has_related_synonym: retinoic acid receptor antagonists
id: CHEBI:90714
in subset: 3 STAR

retinoic acid receptor beta agonist
type: Class
subclass of: retinoic acid receptor agonist
textual definition: Any retinoic acid receptor (RAR) agonist with specificity for RARbeta.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: RAR beta agonist
has_related_synonym: RAR beta agonists
has_related_synonym: RARbeta agonist
has_related_synonym: RARbeta agonists
has_related_synonym: retinoic acid receptor beta agonists
id: CHEBI:90742
in subset: 3 STAR

retinoic acid receptor gamma antagonist
type: Class
subclass of: retinoic acid receptor antagonist
textual definition: A retinoic acid receptor antagonist that antagonises retinoic acid receptor gamma.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: RAR gamma antagonist
has_related_synonym: RAR gamma antagonists
has_related_synonym: RARgamma antagonist
has_related_synonym: RARgamma antagonists
has_related_synonym: retinoic acid receptor gamma antagonists
id: CHEBI:90744
in subset: 3 STAR

antidote to cyanide poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralize the deleterious effects of cyanide.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:90749
in subset: 3 STAR

antidote to organophosphate poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralise the deleterious effects of organophosphates or acetylcholinesterase inhibitors (nerve agents).
imported from: chebi.owl
has_alternative_id: CHEBI:90758
has_obo_namespace: chebi_ontology
has_related_synonym: antidote to acetylcholinesterase inhibitor poisoning
has_related_synonym: antidote to nerve agents
id: CHEBI:90753
in subset: 3 STAR

antidote to opioid poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralise the deleterious effects of opioids.
imported from: chebi.owl
has cross-reference: PMID:24510187
has cross-reference: PMID:24868924
has_obo_namespace: chebi_ontology
has_related_synonym: antidote to opioid overdose
id: CHEBI:90755
in subset: 3 STAR

antidote to benzodiazepine poisoning
type: Class
subclass of: antidote
textual definition: A role borne by a molecule that acts to counteract or neutralise the deleterious effects of benzodiazepines.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidote to benzodiazepine overdose
id: CHEBI:90757
in subset: 3 STAR

eukaryotic translation elongation factor 1alpha 1 inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any compound that inihibits the human protein, eukaryotic translation elongation factor 1alpha 1.
imported from: chebi.owl
has cross-reference: Wikipedia:Eukaryotic_translation_elongation_factor_1_alpha_1
has_obo_namespace: chebi_ontology
has_related_synonym: EEF1A1 inhibitor
has_related_synonym: EEF1A1 inhibitors
has_related_synonym: eEF1A inhibitor
has_related_synonym: eEF1A inhibitors
has_related_synonym: eukaryotic translation elongation factor 1alpha 1 inhibitors
id: CHEBI:90767
in subset: 3 STAR

AKT1 kinase inhibitor
type: Class
subclass of: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
textual definition: A serine/threonine kinase inhibitor that specifically inhibits RAC-alpha serine/threonine-protein kinase (ATK1).
imported from: chebi.owl
has cross-reference: Wikipedia:AKT1
has_obo_namespace: chebi_ontology
has_related_synonym: AKT1 kinase inhibitors
has_related_synonym: RAC-alpha serine/threonine-protein kinase inhibitor
has_related_synonym: RAC-alpha serine/threonine-protein kinase inhibitors
id: CHEBI:90780
in subset: 3 STAR

prostacyclin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that binds to and activates prostacyclin receptors
imported from: chebi.owl
has cross-reference: Wikipedia:Prostacyclin_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: IP receptor agonist
has_related_synonym: IP receptor agonists
has_related_synonym: IP1 agonist
has_related_synonym: IP1 agonists
has_related_synonym: prostacyclin receptor I2 agonist
has_related_synonym: prostacyclin receptor I2 agonists
has_related_synonym: prostacyclin receptor agonists
id: CHEBI:90845
in subset: 3 STAR

liver X receptor inverse agonist
type: Class
subclass of: inverse agonist
textual definition: An inverse agonist that binds to the same receptor as a liver X receptor agonist, but which induces a pharmacological response opposite to that agonist.
imported from: chebi.owl
has cross-reference: PMID:23237488
has cross-reference: PMID:23665929
has cross-reference: PMID:25830098
has_obo_namespace: chebi_ontology
has_related_synonym: LXR inverse agonist
has_related_synonym: LXR inverse agonists
has_related_synonym: liver X receptor inverse agonists
id: CHEBI:90846
in subset: 3 STAR

inverse agonist
type: Class
subclass of: pharmacological role
textual definition: A substance that binds to the same receptor binding-site as an agonist for that receptor, but which exerts the opposite pharmacological effect.
imported from: chebi.owl
has cross-reference: Wikipedia:Inverse_agonist
has_obo_namespace: chebi_ontology
has_related_synonym: inverse agonists
id: CHEBI:90847
in subset: 3 STAR

EC 2.4.2.4 (thymidine phosphorylase) inhibitor
type: Class
subclass of: EC 2.4.2.* (pentosyltransferase) inhibitor
textual definition: An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of thymidine phosphorylase (EC 2.4.2.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Thymidine_phosphorylase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 2.4.2.4 (thymidine phosphorylase) inhibitors
has_related_synonym: EC 2.4.2.4 inhibitor
has_related_synonym: EC 2.4.2.4 inhibitors
has_related_synonym: deoxythymidine phosphorylase inhibitor
has_related_synonym: deoxythymidine phosphorylase inhibitors
has_related_synonym: pyrimidine deoxynucleoside phosphorylase inhibitor
has_related_synonym: pyrimidine deoxynucleoside phosphorylase inhibitors
has_related_synonym: pyrimidine phosphorylase inhibitor
has_related_synonym: pyrimidine phosphorylase inhibitors
has_related_synonym: thymidine phosphorylase inhibitor
has_related_synonym: thymidine phosphorylase inhibitors
has_related_synonym: thymidine-orthophosphate deoxyribosyltransferase inhibitor
has_related_synonym: thymidine-orthophosphate deoxyribosyltransferase inhibitors
has_related_synonym: thymidine:phosphate deoxy-D-ribosyltransferase inhibitor
has_related_synonym: thymidine:phosphate deoxy-D-ribosyltransferase inhibitors
has_related_synonym: thymidine:phosphate deoxy-alpha-D-ribosyltransferase inhibitor
has_related_synonym: thymidine:phosphate deoxy-alpha-D-ribosyltransferase inhibitors
id: CHEBI:90878
in subset: 3 STAR

EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitor
type: Class
subclass of: EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor
textual definition: Any EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor that interferes with the action of any such enzyme using a quinone or similar compound as an acceptor.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitors
has_related_synonym: EC 1.8.5.* inhibitor
has_related_synonym: EC 1.8.5.* inhibitors
has_related_synonym: oxidoreductase acting on sulfur group donors, quinone or similar as acceptor (EC 1.8.5.*) inhibitor
has_related_synonym: oxidoreductase acting on sulfur group donors, quinone or similar as acceptor (EC 1.8.5.*) inhibitors
id: CHEBI:90920
in subset: 3 STAR

EC 1.8.5.4 (sulfide:quinone reductase) inhibitor
type: Class
subclass of: EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitor
textual definition: An EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitor that interferes with the action of sulfide:quinone reductase (EC 1.8.5.4).
imported from: chebi.owl
has cross-reference: Wikipedia:Sulfide:quinone_reductase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.8.5.4 (sulfide:quinone reductase) inhibitors
has_related_synonym: EC 1.8.5.4 inhibitor
has_related_synonym: EC 1.8.5.4 inhibitors
has_related_synonym: sulfide:quinone oxidoreductase inhibitor
has_related_synonym: sulfide:quinone oxidoreductase inhibitors
has_related_synonym: sulfide:quinone reductase (EC 1.8.5.4) inhibitor
has_related_synonym: sulfide:quinone reductase (EC 1.8.5.4) inhibitors
has_related_synonym: sulfide:quinone reductase inhibitor
has_related_synonym: sulfide:quinone reductase inhibitors
id: CHEBI:90921
in subset: 3 STAR

ERK dimerisation inhibitor
type: Class
subclass of: inhibitor
textual definition: An inhibitor that interferes with the dimerisation of extracellular signal-regulated kinase (ERK).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ERK dimerisation inhibitors
has_related_synonym: extracellular signal-regulated kinase dimerisation inhibitor
has_related_synonym: extracellular signal-regulated kinase dimerisation inhibitors
id: CHEBI:90961
in subset: 3 STAR

steroid receptor coactivator stimulator
type: Class
subclass of: biochemical role
textual definition: A compound that enhances the activity of a steroid receptor coactivator.
imported from: chebi.owl
has cross-reference: PMID:26267537
has_obo_namespace: chebi_ontology
has_related_synonym: SRC stimulator
has_related_synonym: SRC stimulators
has_related_synonym: steroid receptor coactivator small molecule stimulator
has_related_synonym: steroid receptor coactivator small molecule stimulators
has_related_synonym: steroid receptor coactivator stimulators
id: CHEBI:90991
in subset: 3 STAR

corrosion inhibitor
type: Class
subclass of: chemical role
textual definition: A chemical compound that, when added to a liquid or gas, decreases the corrosion rate of a material, typically a metal or an alloy.
imported from: chebi.owl
has cross-reference: PMID:23636692
has cross-reference: PMID:25594340
has cross-reference: PMID:25839822
has cross-reference: PMID:25912625
has cross-reference: PMID:25955130
has cross-reference: PMID:26160863
has cross-reference: PMID:26343626
has cross-reference: PMID:26347374
has cross-reference: PMID:26364631
has cross-reference: PMID:26727190
has cross-reference: Wikipedia:Corrosion_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: corrosion inhibitors
id: CHEBI:91015
in subset: 3 STAR

GABAA receptor agonist
type: Class
subclass of: GABA agonist
textual definition: A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: GABAA receptor agonists
id: CHEBI:91016
in subset: 3 STAR

erythropoietin inhibitor
type: Class
subclass of: inhibitor
textual definition: Any inhibitor of erythropoietin, a glycoprotein hormone that controls erythropoiesis (red blood cell production).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EPO inhibitor
has_related_synonym: EPO inhibitors
has_related_synonym: erythropoietin inhibitors
id: CHEBI:91025
in subset: 3 STAR

purinergic receptor P2 antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist at purinergic P2 receptors
imported from: chebi.owl
has cross-reference: Wikipedia:Purinergic_receptor
has_obo_namespace: chebi_ontology
has_related_synonym: P2 antagonist
has_related_synonym: P2 antagonists
has_related_synonym: non-selective P2 purinergic antagonist
has_related_synonym: non-selective P2 purinergic antagonists
has_related_synonym: purinergic receptor P2 antagonists
id: CHEBI:91079
in subset: 3 STAR

purinergic receptor P2X antagonist
type: Class
subclass of: purinergic receptor P2 antagonist
textual definition: An antagonist at purinergic P2X receptors
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: P2X antagonist
has_related_synonym: P2X antagonists
has_related_synonym: purinergic receptor P2X antagonists
id: CHEBI:91081
in subset: 3 STAR

collagen cross-linking inhibitor
type: Class
subclass of: inhibitor
textual definition: Any compound that inhibits collagen cross-linking.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: collagen cross-linking inhibitors
id: CHEBI:91085
in subset: 3 STAR

EC 2.7.11.26 (tau-protein kinase) inhibitor
type: Class
subclass of: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
textual definition: An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).
imported from: chebi.owl
has cross-reference: Wikipedia:GSK-3
has_obo_namespace: chebi_ontology
has_related_synonym: ATP:[tau-protein] O-phosphotransferase inhibitor
has_related_synonym: ATP:[tau-protein] O-phosphotransferase inhibitors
has_related_synonym: ATP:tau-protein O-phosphotransferase inhibitor
has_related_synonym: ATP:tau-protein O-phosphotransferase inhibitors
has_related_synonym: CDK5/p23 inhibitor
has_related_synonym: CDK5/p23 inhibitors
has_related_synonym: EC 2.7.11.26 (tau-protein kinase) inhibitors
has_related_synonym: EC 2.7.11.26 inhibitor
has_related_synonym: EC 2.7.11.26 inhibitors
has_related_synonym: GSK inhibitor
has_related_synonym: GSK inhibitors
has_related_synonym: GSK-3 inhibitor
has_related_synonym: GSK-3 inhibitors
has_related_synonym: STK31 inhibitor
has_related_synonym: STK31 inhibitors
has_related_synonym: TPK I inhibitor
has_related_synonym: TPK I inhibitors
has_related_synonym: TPK II inhibitor
has_related_synonym: TPK II inhibitors
has_related_synonym: TPK inhibitor
has_related_synonym: TPK inhibitors
has_related_synonym: TTK inhibitor
has_related_synonym: TTK inhibitors
has_related_synonym: [tau-protein] kinase inhibitor
has_related_synonym: [tau-protein] kinase inhibitors
has_related_synonym: brain protein kinase PK40erk inhibitor
has_related_synonym: brain protein kinase PK40erk inhibitors
has_related_synonym: cdk5/p20 inhibitor
has_related_synonym: cdk5/p20 inhibitors
has_related_synonym: glycogen synthase kinase-3beta inhibitor
has_related_synonym: glycogen synthase kinase-3beta inhibitors
has_related_synonym: protein tau kinase inhibitor
has_related_synonym: protein tau kinase inhibitors
has_related_synonym: tau kinase inhibitor
has_related_synonym: tau kinase inhibitors
has_related_synonym: tau-protein kinase I inhibitor
has_related_synonym: tau-protein kinase I inhibitors
has_related_synonym: tau-protein kinase II inhibitor
has_related_synonym: tau-protein kinase II inhibitors
has_related_synonym: tau-tubulin inhibitor
has_related_synonym: tau-tubulin inhibitors
id: CHEBI:91092
in subset: 3 STAR

elastin-laminin receptor agonist
type: Class
subclass of: agonist
textual definition: An agonist that selectively binds to and activates elastin-laminin receptors.
imported from: chebi.owl
has cross-reference: PMID:9856283
has_obo_namespace: chebi_ontology
has_related_synonym: ELR agonist
has_related_synonym: ELR agonists
has_related_synonym: elastin-laminin receptor agonists
id: CHEBI:91139
in subset: 3 STAR

EC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor
textual definition: An EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor that interferes with the action of glycerol-3-phosphate dehydrogenase (EC 1.1.5.3).
imported from: chebi.owl
has cross-reference: Wikipedia:Glycerol-3-phosphate_dehydrogenase
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitors
has_related_synonym: EC 1.1.5.3 inhibitor
has_related_synonym: EC 1.1.5.3 inhibitors
has_related_synonym: glycerol-3-phosphate dehydrogenase inhibitor
has_related_synonym: glycerol-3-phosphate dehydrogenase inhibitors
id: CHEBI:91141
in subset: 3 STAR

EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor
type: Class
subclass of: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
textual definition: An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that interferes with the action of any such enzyme using a quinone or similar compound as acceptor (EC 1.1.5.*).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or simliar compound as acceptor) inhibitors
has_related_synonym: EC 1.1.5.* inhibitor
has_related_synonym: EC 1.1.5.* inhibitors
has_related_synonym: oxidoreductase acting on donor CH-OH group, quinone or simliar compound as acceptor (EC 1.1.5.*) inhibitor
has_related_synonym: oxidoreductase acting on donor CH-OH group, quinone or simliar compound as acceptor (EC 1.1.5.*) inhibitors
id: CHEBI:91142
in subset: 3 STAR

VEGF activator
type: Class
subclass of: activator
textual definition: Any activator of vascular endothelial growth factor (VEGF).
imported from: chebi.owl
has cross-reference: Wikipedia:Vascular_endothelial_growth_factor
has_obo_namespace: chebi_ontology
has_related_synonym: VEGF activators
has_related_synonym: VEGF inducer
has_related_synonym: VEGF inducers
has_related_synonym: vascular endothelial growth factor activator
has_related_synonym: vascular endothelial growth factor activators
has_related_synonym: vascular endothelial growth factor inducer
has_related_synonym: vascular endothelial growth factor inducers
id: CHEBI:91189
in subset: 3 STAR

lysophosphatidic acid receptor antagonist
type: Class
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates lysophosphatidic acid receptors.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: LPA receptor antagonist
has_related_synonym: LPA receptor antagonists
has_related_synonym: LPAR antagonist
has_related_synonym: LPAR antagonists
has_related_synonym: lysophosphatidic acid receptor antagonists
id: CHEBI:91193
in subset: 3 STAR

TGFbeta receptor antagonist
type: Class
subclass of: EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor
subclass of: antagonist
textual definition: An antagonist that binds to and deactivates TGFbeta receptors.
imported from: chebi.owl
has cross-reference: Wikipedia:TGF_beta_receptors
has_obo_namespace: chebi_ontology
has_related_synonym: TGFR antagonist
has_related_synonym: TGFR antagonists
has_related_synonym: TGFbeta receptor antagonists
has_related_synonym: transforming growth factor receptor antagonist
has_related_synonym: transforming growth factor receptor antagonists
id: CHEBI:91202
in subset: 3 STAR

macrophage migration inhibitory factor inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: Any inhibitor of macrophage migration inhibitory factor (MIF).
imported from: chebi.owl
has cross-reference: Wikipedia:Macrophage_migration_inhibitory_factor
has_obo_namespace: chebi_ontology
has_related_synonym: MIF inhibitor
has_related_synonym: MIF inhibitors
has_related_synonym: macrophage migration inhibitory factor inhibitors
id: CHEBI:91214
in subset: 3 STAR

tienilic acid
type: Class
subclass of: molecular entity
textual definition: An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.
imported from: chebi.owl
charge: 0
formula: C13H8Cl2O4S
inchi: InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)
inchikey: AGHANLSBXUWXTB-UHFFFAOYSA-N
mass: 331.17100
monoisotopicmass: 329.95204
smiles: OC(=O)COc1ccc(C(=O)c2cccs2)c(Cl)c1Cl
has cross-reference: CAS:40180-04-9
has cross-reference: DrugBank:DB04831
has cross-reference: Drug_Central:2658
has cross-reference: KEGG:C11702
has cross-reference: KEGG:D02386
has cross-reference: LINCS:LSM-5478
has cross-reference: PMID:22462724
has cross-reference: PMID:23013248
has cross-reference: PMID:24575896
has cross-reference: PMID:2714684
has cross-reference: PMID:41229
has cross-reference: PMID:471149
has cross-reference: PMID:471154
has cross-reference: PMID:504040
has cross-reference: PMID:6996137
has cross-reference: PMID:7004678
has cross-reference: PMID:7074982
has cross-reference: PMID:7128663
has cross-reference: PMID:7398677
has cross-reference: PMID:8823314
has cross-reference: PMID:913063
has cross-reference: Reaxys:1260086
has cross-reference: Wikipedia:Tienilic_acid
alternative_term: [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid
has_related_synonym: (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid
has_related_synonym: 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure
has_related_synonym: 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid
has_related_synonym: Thienylic acid
has_related_synonym: Ticrynafen
has_related_synonym: acide tienilique
has_related_synonym: acido tienilico
has_related_synonym: acidum tienilicum
has_related_synonym: tienilic acid
id: CHEBI:9590
in subset: 3 STAR

cell line cell
type: Class
subclass of: BAO_0003114
editor preferred label: cell line cell
textual definition: A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
term editor: Yongqun He, Matthew Brush, Sirarat Sarntivijai, Alexander Diehl, Jie Zheng, Yu Lin, Bjoern Peters
imported from: clo.owl
imported from: obi.owl
comment: A 'cell line cell' is a part of a cell line established through the passaging/selection of a primary cultured cells or the experimental modification of an existing cell line. New types of cell line cells are established after sufficient passaging of a primary culture to establish a stable and homogenous population that qualifies as a line (typically 1-20 passages), or following some spontaneous or experimental modification that confers novel characteristics to an existing line. A cell line cell typically has mutations of five or more genes compared to the original cell that derives the cell line cell. Some gene mutations may turn on some oncogenes. Cell line cells can be in active culture, stored in a quiescent state for future use (e.g. frozen in liquid nitrogen), or applied in experimental procedures.

immortal cell line cell
type: Class
subclass of: cell line cell
editor preferred label: immortal cell line cell
textual definition: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line.
term editor: Yongqun He, Matthew Brush, Allen Xiang, Asiyah Yu Lin, Sirarat Sarntivijai, James Malone, Jie Zheng, Tomasz Adamusiak
alternative term: continuous cell line cell
alternative term: permanent cell line cell
imported from: clo.owl
imported from: obi.owl

cell line
type: Class
subclass of: BAO_0003114
editor preferred label: cell line
example of usage: He, Tong-Chuan, et al., Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512.: "To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene". Note that common usage in the literature is often of the form "a human colorectal cancer cell line", as seen above. But such references to studies in "a line" refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'.
textual definition: A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).
editor note: In the spring of 2013, a working group comprised of domain experts and representatives from CLO, OBI, CL, and ReO worked to establish a consensus model and definitions of cultured cells across these efforts. This included a careful characterization of how the term 'cell line' should be defined and applied. Notes about this work and its outcomes can be found on the CLO wiki here: http://code.google.com/p/clo-ontology/wiki/Cell_Lines
term editor: MB, SS, JZ, MAH, BP, CS, YH
imported from: clo.owl
imported from: obi.owl
comment: The term 'line' is used when a culture has undergone an intentional experimental process to establish a more uniform and stable population of cells (see 'establishing cell line'). This will require one or more passages, but may involve additional selection processes. Through such passaging and/or selection processes, the resulting 'line' attains some level of genetic stability and compositional homogeneity which is typically absent in primary cultures. Because of their relative homogeneity, ‘lines’ are capable of being characterized and stably propagated over a period of time. A new *type* of cell line can be established not only through the passaging/selection of a primary culture, but also through experimental modifications of existing lines (e.g. immortalization, stable genetic modifications, drug selection for a resistant subset, etc.). The definition provided here establishes the 'scale' of cell populations that qualify as cell lines - specifically those with a shared propagation history in culture. In this way, the 'cell line' class demarcates populations that represent what researchers actually use in the practice of science - e.g. as inputs to culturing, experimentation, and sharing. The definition is such that cell lines will exhibit important attributes. For example, they will have a relatively homogenous cell type composition as they have experienced similar selective pressures due to their continuous co-propagation. In addition, these populations can also be characterized by a passage number, again owing to their common passaging history. As defined here, 'cell line' can refer to a population of cells in active culture, applied experimentally, or stored in a quiescent state for future use.

697 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1042
alternative term: 697
imported from: clo.owl
see also: CHEMBL: CHEMBL3308147
see also: CVCL: CVCL_0079
see also: HyperCLDB: cl117
see also: Sanger: COSMIC ID:906800

HEK293
type: Class
subclass of: immortal cell line cell
alternative term: 293
alternative term: 293 HEK
alternative term: 293 cell
alternative term: HEK 293
alternative term: HEK-293
alternative term: Human Embryonic Kidney 293
definition source: WEB: http://hek293.com/
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0045
definition source: WEB: https://www.atcc.org/Products/All/CRL-1573.aspx
imported from: clo.owl
see also: ATCC: CRL-1573
see also: BTO: BTO_0000007
see also: EFO: EFO_0001182)
see also: RRID: CVCL_0045

293T/17 cell
type: Class
subclass of: immortal cell line cell
alternative term: 293T/17
definition source: WEB: https://www.atcc.org/Products/All/CRL-11268.aspx
imported from: clo.owl
see also: ATCC: CRL-11268

A549 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1601
alternative term: A549
imported from: clo.owl
see also: ATCC: CCL-185
see also: CHEMBL: CHEMBL3307651
see also: CVCL: CVCL_0023
see also: EFO: EFO_0001086
see also: HyperCLDB: cl207

ACHN cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1756
alternative term: ACHN
imported from: clo.owl
see also: ATCC: CRL-1611
see also: CHEMBL: CHEMBL3307633
see also: CVCL: CVCL_1067
see also: EFO: EFO_0002108

AML12 cell
type: Class
subclass of: immortal cell line cell
alternative term: AML12
imported from: clo.owl
see also: ATCC: CRL-2254

BA/F3 cell
type: Class
subclass of: immortal cell line cell
alternative term: BA/F3
imported from: clo.owl
see also: HyperCLDB: cl5028

BT-549 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1310
alternative term: BT-549
imported from: clo.owl
comment: disease: ductal carcinoma
see also: ATCC: HTB-122
see also: CHEMBL: CHEMBL3308490
see also: CVCL: CVCL_1092
see also: EFO: EFO_0001096

C-33 A cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1300
alternative term: C-33 A
imported from: clo.owl
see also: ATCC: HTB-31

Caco-2 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1170
alternative term: Caco-2
imported from: clo.owl
comment: disease: colorectal adenocarcinoma
see also: ATCC: HTB-37
see also: CHEMBL: CHEMBL3307519
see also: CVCL: CVCL_0025
see also: EFO: EFO_0001099
see also: HyperCLDB: cl618
see also: MeSH: D018938

CAKI-1 cell
type: Class
subclass of: immortal cell line cell
alternative term: CAKI-1
imported from: clo.owl
see also: HyperCLDB: cl623

Caki-1 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1774
alternative term: Caki-1
imported from: clo.owl
comment: disease: clear cell carcinoma (kidney primary)
see also: ATCC: HTB-46
see also: CHEMBL: CHEMBL3307522
see also: CVCL: CVCL_0234
see also: EFO: EFO_0002149

Calu-1 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1580
term editor: ZN
alternative term: Calu-1
imported from: clo.owl
comment: disease: epidermoid carcinoma (lung primary)
see also: ATCC: HTB-54
see also: CHEMBL: CHEMBL3308031
see also: CVCL: CVCL_0608
see also: EFO: EFO_0002151
see also: HyperCLDB: cl631
see also: HyperCLDB: cl632

CCRF-CEM cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1012
alternative term: CCRF-CEM
imported from: clo.owl
see also: ATCC: CCL-119
see also: CHEMBL: CHEMBL3307641
see also: CVCL: CVCL_0207
see also: EFO: EFO_0002128

CHL-1 cell
type: Class
subclass of: immortal cell line cell
alternative term: CHL-1
imported from: clo.owl
see also: ATCC: CRL-9446

CHO cell
type: Class
subclass of: immortal cell line cell
alternative term: CHO
alternative term: Chinese Hamster Ovary cell
imported from: clo.owl
see also: HyperCLDB: cl721
see also: MeSH: D016466

CHO-K1 cell
type: Class
subclass of: immortal cell line cell
alternative term: CHO-K1
imported from: clo.owl
see also: ATCC: CCL-61

COLO 205 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1173
alternative term: COLO 205
imported from: clo.owl
comment: disease: colorectal adenocarcinoma (colon primary)
see also: ATCC: CCL-222
see also: CHEMBL: CHEMBL3308348
see also: CVCL: CVCL_0218
see also: ECACC: 87061208
see also: EFO: EFO_0003082

COS-7 cell
type: Class
subclass of: immortal cell line cell
alternative term: COS-7
imported from: clo.owl
see also: ATCC: CRL-1651
see also: MeSH: D019556

DLD-1 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1175
alternative term: DLD-1
imported from: clo.owl
comment: disease: colorectal adenocarcinoma
see also: ATCC: CCL-221
see also: CHEMBL: CHEMBL3307580
see also: CVCL: CVCL_0248

DU 145 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1146
alternative term: DU 145
imported from: clo.owl
comment: disease: carcinoma (prostate primary)
see also: ATCC: HTB-81

H-4-II-E cell
type: Class
subclass of: immortal cell line cell
alternative term: H-4-II-E
imported from: clo.owl
comment: disease: hepatoma
see also: ATCC: CRL-1548

H69AR cell
type: Class
subclass of: immortal cell line cell
alternative term: H69AR
imported from: clo.owl
comment: disease: carcinoma; small cell lung cancer; multidrug resistant
see also: ATCC: CRL-11351

HCT 116 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1161
textual definition: immortal human epithelial cell line cell that was derived from some colon epithelial cell from a human patient with the disease colon carcinoma
alternative term: HCT 116
alternative term: HCT-116
alternative term: HCT116
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0291
definition source: WEB: https://www.atcc.org/products/all/CCL-247.aspx
imported from: clo.owl
comment: disease: colorectal carcinoma
see also: ATCC: CCL-247
see also: ECACC: 91091005
see also: HyperCLDB: cl1575
see also: MeSH: D045325

HEL cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1053
alternative term: HEL
imported from: clo.owl
see also: CHEMBL: CHEMBL3308090
see also: CVCL: CVCL_0001
see also: DSMZ: ACC 11
see also: HyperCLDB: cl1585

HeLa cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1512
textual definition: an immortal human uterine cervix-derived epithelial cell line that was derived from cervical adenocarcinoma cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of her cancer on October 4, 1951.
alternative term: HeLa
definition source: WEB: http://en.wikipedia.org/wiki/HeLa
definition source: WEB: http://www.atcc.org/products/all/CCL-2.aspx
definition source: WEB: https://www.ncbi.nlm.nih.gov/pubmed/12001993
imported from: clo.owl
see also: ATCC: CCL-2
see also: CHEMBL: CHEMBL3308376
see also: EFO: EFO_0001185
see also: HyperCLDB: cl1601
see also: MeSH: D006367

Hep G2 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1925
alternative term: HEP G2
alternative term: HEP-G2
alternative term: HEPG2
alternative term: Hep G2
alternative term: HepG2
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0027
definition source: WEB: https://en.wikipedia.org/wiki/Hep_G2
definition source: WEB: https://www.atcc.org/products/all/HB-8065.aspx
imported from: clo.owl
see also: ATCC: HB-8065
see also: HyperCLDB: cl1644

HL-60 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1054
alternative term: HL-60
imported from: clo.owl
comment: disease: promyeloblast; acute promyelocytic leukemia
see also: ATCC: CCL-240
see also: CHEMBL: CHEMBL3307654
see also: CVCL: CVCL_0002
see also: EFO: EFO_0002793
see also: HyperCLDB: cl1684
see also: HyperCLDB: cl1689
see also: MeSH: D018922

Hs 578T cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1315
alternative term: HS578T
alternative term: Hs 578T
imported from: clo.owl
comment: disease: ductal carcinoma
see also: ATCC: HTB-126

HT-1080 cell
type: Class
subclass of: immortal cell line cell
alternative term: HT-1080
imported from: clo.owl
comment: disease: fibrosarcoma
see also: ATCC: CCL-121

HT-29 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1180
alternative term: HT-29
alternative term: HT29
imported from: clo.owl
comment: disease: colorectal adenocarcinoma
see also: ATCC: HTB-38
see also: CHEMBL: CHEMBL3307768
see also: CVCL: CVCL_0320
see also: EFO: EFO_0001193
see also: HyperCLDB: cl1752
see also: MeSH: D019073

HUV-EC-C cell
type: Class
subclass of: immortal cell line cell
alternative term: HUV-EC-C
alternative term: HUVEC
definition source: WEB: https://www.atcc.org/Products/All/CRL-1730.aspx
imported from: clo.owl
see also: ATCC: CRL-1730

IEC-6 cell
type: Class
subclass of: immortal cell line cell
alternative term: IEC-6
imported from: clo.owl
comment: disease: epithelium
see also: ATCC: CRL-1592
see also: HyperCLDB: cl1802

JURKAT cell
type: Class
subclass of: immortal cell line cell
textual definition: an immortalized human T lymphocyte cell that was derived in the late 1970s from the peripheral blood of a 14-year-old boy with T cell leukemia
alternative term: JURKAT
definition source: WEB: https://en.wikipedia.org/wiki/Jurkat_cells
imported from: clo.owl
comment: disease: leukemia, T cell
see also: HyperCLDB: cl5296
see also: MeSH: D019169
see also: RRID: CVCL_0065

L6 cell
type: Class
subclass of: immortal cell line cell
alternative term: L6
imported from: clo.owl
see also: ATCC: CRL-1458

LLC-PK subscript(1) cell
type: Class
subclass of: immortal cell line cell
alternative term: LLC-PK subscript(1)
imported from: clo.owl
see also: ATCC: CL-101
see also: HyperCLDB: cl3221
see also: MeSH: D018374

MCF7 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1460
textual definition: an immortal breast cancer cell line cell isolated in 1970 from a 69-year-old Caucasian woman.
term editor: ZN
alternative term: MCF 7 cell
alternative term: MCF-7 cell
alternative term: MCF7
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0031
definition source: WEB: https://en.wikipedia.org/wiki/MCF-7
imported from: clo.owl
comment: disease: adenocarcinoma (mammary gland primary)
see also: ATCC: HTB-22
see also: CHEMBL: CHEMBL3308403
see also: EFO: EFO_0002082
see also: HyperCLDB: cl3366
see also: HyperCLDB: cl3372
see also: RRID: CVCL_0031

MDA-MB-231 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1461
textual definition: an immortal breast cancer cell line cell derived from a human patient with breast adenocarcinoma
term editor: ZN, YH
alternative term: MDA-MB-231
imported from: clo.owl
see also: ATCC: HTB-26
see also: CHEMBL: CHEMBL3307960
see also: EFO: EFO_0001209
see also: RRID: CVCL_0062

MDCK cell
type: Class
subclass of: immortal cell line cell
textual definition: A model mammalian cell line cell that was genereated from the initial isolation in 1958 of epithelial cells from the kidney tubule of an adult Cocker Spaniel dog by Stewart H. Madin and Norman B. Darby, Jr..
alternative term: MDCK
definition source: https://en.wikipedia.org/wiki/Madin-Darby_canine_kidney_cells
imported from: clo.owl
alternative term: Madin-Darby canine kidney cell
see also: HyperCLDB: cl5078

ME-180 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1305
alternative term: ME-180
imported from: clo.owl
comment: disease: epidermoid carcinoma (cervix primary)
see also: ATCC: HTB-33
see also: CHEMBL: CHEMBL3308114
see also: CVCL: CVCL_1401

MRC-5 cell
type: Class
subclass of: immortal cell line cell
alternative term: MRC-5
imported from: clo.owl
see also: ATCC: CCL-171
see also: HyperCLDB: cl3564

Mv 1 Lu cell
type: Class
subclass of: immortal cell line cell
alternative term: Mv 1 Lu
imported from: clo.owl
see also: HyperCLDB: cl3604
see also: HyperCLDB: cl3608
see also: HyperCLDB: cl3609

NIH-3T3 cell
type: Class
subclass of: immortal cell line cell
alternative term: NIH-3T3
imported from: clo.owl
see also: ATCC: CRL-1658
see also: HyperCLDB: cl3710
see also: HyperCLDB: cl3711
see also: MeSH: D041681

SH-SY5Y cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-2000
alternative term: SH-SY5Y
alternative term: SHSY5Y
definition source: https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Bone_Marrow/CRL-2266.aspx
imported from: clo.owl
see also: ATCC: CRL-2266

SK-MEL-5 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1282
textual definition: A melanoma cell line cell. This cell line was established in 1974 from a metastatic site (axillary lymph node) in a 24-year-old Caucasian female with malignant melanoma, expresses mutant B-Raf (V600E) and wildtype N-Ras.
alternative term: SK-MEL-5
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_1706
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/3121170
definition source: WEB: https://strap.nci.nih.gov/celline_detail.php?sample_id=56
imported from: clo.owl
see also: ATCC: HTB-70
see also: CHEMBL: CHEMBL3307744
see also: CVCL: CVCL_0527
see also: EFO: EFO_0002080
see also: PubChem AID: 488899
see also: Sanger: COSMIC ID:905956

SK-N-SH cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1971
alternative term: SK-N-SH
imported from: clo.owl
see also: ATCC: HTB-11
see also: CHEMBL: CHEMBL3307745
see also: CVCL: CVCL_0531
see also: EFO: EFO_0003072

SW403 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1195
alternative term: SW403
imported from: clo.owl
see also: ATCC: CCL-230
see also: PubChem AID: 504653
see also: RRID: CVCL_0545
see also: Sanger: COSMIC ID:910908

THP-1 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1072
alternative term: THP-1
alternative term: THP1
imported from: clo.owl
see also: ATCC: TIB-202
see also: CHEMBL: CHEMBL3307574
see also: CVCL: CVCL_0006
see also: EFO: EFO_0001253
see also: HyperCLDB: cl4514

U-2 OS cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1431
alternative term: U-2 OS
alternative term: U2OS
definition source: WEB: https://www.atcc.org/Products/All/HTB-96.aspx
imported from: clo.owl
see also: ATCC: HTB-96
see also: CHEMBL: CHEMBL3307757
see also: CVCL: CVCL_0042
see also: EFO: EFO_0002869

obsolete: U87 MG cell
type: Class
subclass of: immortal cell line cell
alternative term: U87 MG
imported from: clo.owl
comment: There is a CLO term for the cell line already: http://purl.obolibrary.org/obo/CLO_0009464
see also: HyperCLDB: cl5280

Vero cell
type: Class
subclass of: immortal cell line cell
alternative term: Vero
imported from: clo.owl
see also: ATCC: CCL-81
see also: HyperCLDB: cl4644
see also: MeSH: D014709

VERO 76 cell
type: Class
subclass of: immortal cell line cell
alternative term: VERO 76
imported from: clo.owl
see also: ATCC: CRL-1587
see also: HyperCLDB: cl4655

VERO C1008 cell
type: Class
subclass of: immortal cell line cell
alternative term: VERO C1008
imported from: clo.owl
see also: ATCC: CRL-1586
see also: HyperCLDB: cl4656
see also: HyperCLDB: cl4657

SNB75 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1346
textual definition: A human glioblastoma cell line cell. The cell line is part of the NCI-60 screening panel.
term editor: Oliver He, Jiangan Xie
alternative term: SNB-75
alternative term: SNB75
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_1706
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/3121170
definition source: WEB: https://strap.nci.nih.gov/celline_detail.php?sample_id=56
imported from: clo.owl
see also: PubChem AID: 652144
see also: Sanger: COSMIC ID:905982

SU-DHL-10 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1134
term editor: Oliver He, Jiangan Xie
alternative term: SU-DHL-10
imported from: clo.owl
see also: DSMZ: ACC 576

SU-DHL-6 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1138
term editor: Oliver He, Jiangan Xie
alternative term: SU-DHL-6
imported from: clo.owl
see also: DSMZ: ACC 572

BJeLR cell
type: Class
subclass of: immortal cell line cell
textual definition: BJeLR cell is BJ fibroblast cell line cell transformed with hTERT, genomic SV40 LT and ST oncoproteins, and oncogenic HRASV12.
term editor: YH, JX
alternative term: BJeLR
definition source: PubChem probe report: http://www.ncbi.nlm.nih.gov/books/NBK98919/
definition source: PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18355723
imported from: clo.owl
see also: PubChem AID: 2635

BJeH cell
type: Class
subclass of: immortal cell line cell
textual definition: BJeH=BJ derivative transformed only with hTERT (BJ fibroblasts were derived from primary human cells by transformation with hTERT, genomic SV40 Large T (LT) and Ssmall T (ST))
term editor: YH, JX
alternative term: BJeLR
definition source: PubChem probe report: http://www.ncbi.nlm.nih.gov/books/NBK98919/
definition source: PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18355723
imported from: clo.owl
see also: PUbChem AID: 493051

RS-11846 cell
type: Class
subclass of: immortal cell line cell
textual definition: A human follicular lymphoms cell line
term editor: Oliver He, Jiangan Xie
alternative term: RS11846
definition source: WEB: http://cellfinder.org/ontology?id=CELDA_00012667
imported from: clo.owl
see also: PubChem AID: 743410
see also: RRID: CVCL_E048

CHO-S cell
type: Class
subclass of: immortal cell line cell
textual definition: A derivative of the CHO cell line that is adapted to high-density, serum-free suspension culture
term editor: YH, JX
definition source: WEB: https://www.thermofisher.com/order/catalog/product/R80007
imported from: clo.owl
see also: PubChem AID: 624379

DRD cell
type: Class
subclass of: immortal cell line cell
textual definition: DRD=BJ fibroblasts expressing hTERT, SV40 small T oncoprotein, dominant negative p53, cyclin D1, a mutant form of CDK4, along with the oncogene HRASV12
term editor: JX, YH
definition source: WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683762/
imported from: clo.owl
see also: PubChem AID: 2633

HL2/3
type: Class
subclass of: immortal cell line cell
textual definition: HL2/3 is a derivative of HeLa cells and contains a stably integrated copies of the HIV-1 molecular clone HXB2/3gpt.
term editor: JX, YH
definition source: WEB: https://www.aidsreagent.org/reagentdetail.cfm?t=cell_lines&id=83
definition source: WEB: https://www.ncbi.nlm.nih.gov/pubmed/?term=2078409
imported from: clo.owl
see also: PubChem AID: 504574

HeLa-MAGI-CCR5
type: Class
subclass of: immortal cell line cell
textual definition: HeLa-MAGI-CCR5 cells are derived from HeLa cells and express human CD4, CXCR4 and CCR5, and an integrated gene encoding the b-galactosidase gene expressed from the HIV long terminal repeat.
term editor: JX, YH
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_D260
imported from: clo.owl
comment: MAGI-CCR5 cells; HeLa-R5-16, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL4 3
see also: PubChem AID: 504341
see also: RRID: CVCL_D260

HeLa-R5-16
type: Class
subclass of: immortal cell line cell
textual definition: HeLa-R5-16 (gift from Roche Palo Alto, LLC) is a derivative of HeLa cells, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL43
term editor: JX, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/?term=16314403
imported from: clo.owl
see also: PubChem AID: 504341

RD-HGA16
type: Class
subclass of: immortal cell line cell
textual definition: RD-HGA16 is derivative of CHO cells stably transfected with the promiscuous G-protein Gα16 gene and hygromycin-resistant. RD-HGA16 is from FLIPR LiveWare Cells (Molecular Devices, Sunnyvale CA), a series of cells and expression vectors successfully used in drug discovery, based on G-protein chimeras developed by Bruce Conklin and colleagues at the Gladstone Institute, UCSF.
term editor: YH, JX
definition source: WEB: http://go.pardot.com/l/83942/2015-06-17/njr/83942/4464/Data_Sheet__FLIPR_LiveWare_G_protein_Cells_and_Plasmids.pdf
imported from: clo.owl
see also: PubChem AID: 624467

Sufu-KO-LIGHT cell
type: Class
subclass of: immortal cell line cell
textual definition: Sufu-KO-LIGHT cells were derived from Sufu knockout mouse embryonic fibroblasts according to the method of Chen et al. [Genes Dev. 2009;23(16): 1910-28.] The cells were co-transfected with the zeocin resistance vector (pVgRXR, Invitrogen) and a firefly luciferase reporter driven by eight Gli binding sites and a γ-crystallin basal promoter (8XGHBS-FL). Sufu-KO-LIGHT lacks Sufu and exhibits constitutive Hh target gene expression in response to endogenous Gli activators.
term editor: JX, YH
definition source: WEB: https://www.google.com/patents/WO2013192301A1?cl=en
imported from: clo.owl
see also: PubChem AID: 588413

Ub-G76V-GFP/HeLa
type: Class
subclass of: immortal cell line cell
textual definition: A Hela-derived cell line cell that expresses ubiquitinated GFP (Green Fluroescent Protein)
term editor: JX, YH
imported from: clo.owl
see also: PubChem AID: 463185

GripTite 293 MSR cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 602478
textual definition: The GripTite™ 293 MSR Cell Line is a genetically engineered Human Embryonic Kidney (HEK 293) cell line that expresses the human macrophage scavenger receptor and strongly adheres to standard tissue culture plates for dependable results.
term editor: BAO, YH
alternative term: GripTite™ 293 MSR
definition source: https://pubchem.ncbi.nlm.nih.gov/bioassay/602478
definition source: https://www.thermofisher.com/order/catalog/product/R79507
imported from: clo.owl
see also: BAO: BAO_0030043
see also: ThermoFisher: R79507

2B4/BCL-2 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 493062
textual definition: A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein BCL-2.
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/16697956
definition source: https://www.google.com/patents/WO2007123791A2
definition source: https://www.ncbi.nlm.nih.gov/books/NBK143557
imported from: clo.owl
see also: BAO: BAO_0030042

2B4/MCL-1 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 493059
textual definition: A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein MCL-1.
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/16697956
definition source: https://www.google.com/patents/WO2007123791A2
definition source: https://www.ncbi.nlm.nih.gov/books/NBK143557
imported from: clo.owl
see also: BAO: BAO_0030044

AVA5 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 463235
textual definition: AVA5 cells are derived from the Huh-7 human hepatoma cell line, stably-expressing the HCV replicon (sub-genomic [CON1], genotype 1b); http://www.apath.com/index.html. See also PMID: 27013634, 1110665, 10390360
term editor: BAO, YH
definition source: https://www.ncbi.nlm.nih.gov/pubmed/10390360
definition source: https://www.ncbi.nlm.nih.gov/pubmed/1110665
definition source: https://www.ncbi.nlm.nih.gov/pubmed/27013634
imported from: clo.owl
see also: BAO: BAO_0030045

BCL-2 1863 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624396
textual definition: A murine leukemia cell line driven by the overexpression of Myc and BCL-2.
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919900/
imported from: clo.owl
see also: BAO: BAO_0030052

C17.2 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 1353
textual definition: An immortalised mouse neural progenitor cell line cell that is capable of differentiation in vitro and is established by retorviral-mediated transduction of the avian myc oncogene into mitotic progenitor cells of neonatal mouse cerrebellum. Mouse strain CD1 x C57BL/6.
term editor: BAO, YH
definition source: http://web.expasy.org/cellosaurus/CVCL_4511
definition source: http://www.sigmaaldrich.com/catalog/product/sigma/07062902
imported from: clo.owl
see also: BAO: BAO_0030046

CEM21 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651610
textual definition: CEM21 (aka CEM#21 or CEM-R5Luc1#21) is derived from CEM.NKR-CCR5 by stable transfecttion of a Tet-activator responsive Luciferase reporter
term editor: Oliver He
alternative term: CEM#21
alternative term: CEM-R5Luc1#21
definition source: https://www.ncbi.nlm.nih.gov/pubmed/10516002
imported from: clo.owl
see also: BAO: BAO_0030049

DPX2 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 434939
textual definition: DPX2 (aka DPX-2) is a HepG2-derived cell line stably integrated with a PXR (pregnane X receptor) expression vector plus a luciferase reporter, used to detect PXR activation/ CYP3A induction
term editor: BAO, YH
alternative term: DPX-2
definition source: http://www.ncbi.nlm.nih.gov/pubmed/15548381
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22912432
imported from: clo.owl
see also: BAO: BAO_0030035

FA2N-4 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 623928
textual definition: FA2N-4 is a human hepatocyte cell line. Reference: http://web.expasy.org/cellosaurus/CVCL_0267
term editor: BAO, YH
definition source: http://cellfinder.org/ontology
definition source: http://purl.bioontology.org/ontology/MCCL/MCC_0000158
definition source: http://web.expasy.org/cellosaurus/CVCL_0267
imported from: clo.owl
see also: BAO: BAO_0030036

HBL-1 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651646
textual definition: HBL-1 (aka human is an EBV-negative B-cell lymphoma cell line established from the pleural effusion of a patient with malignant lymphoma, diffuse, large cell.
term editor: BAO, YH
definition source: http://purl.obolibrary.org/obo/BTO_0002522
definition source: http://web.expasy.org/cellosaurus/CVCL_4213
imported from: clo.owl
see also: BAO: BAO_0030037
see also: BTO: BTO_0002522

HMC-1-8 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 449755
textual definition: HMC-1-8 is a human breast cancer cell line
term editor: BAO, YH
definition source: http://portals.broadinstitute.org/ccle/cell%20lines/HMC18_BREAST
definition source: http://web.expasy.org/cellosaurus/CVCL_2949
imported from: clo.owl
see also: BAO: BAO_0030037

HMLE_sh_ECAD cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 2717
textual definition: HMLE_sh_ECAD is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down E-Cadherin (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT)
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19682730
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22941295
imported from: clo.owl
see also: BAO: BAO_0030038

HMLE_sh_eGFP cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 463074
textual definition: HMLE_sh_eGFP is a human breast epithelial cell line containing shRNA to GFP (green fluorescent reporter); used as an isogenic control line for HMLE_sh_ECAD
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19682730
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22941295
imported from: clo.owl
see also: BAO: BAO_0030039

HMLE_sh_TWIST cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 588703
textual definition: HMLE_sh_TWIST is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down TWIST (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT); isogenic with another CSC line, HMLE_sh_ECAD
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19682730
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22941295
imported from: clo.owl
see also: BAO: BAO_0030040

LEADING LIGHT Wnt Reporter cell line cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651570
textual definition: An engineered 3T3 mouse fibroblast cell line, which expresses the firefly luciferase reporter gene under the control of Wnt-responsive promoters (TCF/LEF).
definition source: http://www.enzolifesciences.com/ENZ-61001/leading-light-wnt-reporter-assay-starter-kit/
imported from: clo.owl
see also: BAO: BAO_0030031

MCL-1 1780 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624396
textual definition: MCL-1 1780 is a murine leukemia cell line driven by the overexpression of Myc and MCL-1.
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919900/
imported from: clo.owl
comment: Source: Anthony Letai (Dana Farber)
see also: BAO: BAO_0030053

MG213 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 652260
textual definition: MG213 is a subline of the BRG1/BRM-deficient cell line SW13 (http://purl.obolibrary.org/obo/CLO_0009185) that contains a stably integrated glucocorticoid-responsive MMTV-luciferase reporter.
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615482/
imported from: clo.owl
see also: BAO: BAO_0030048

PathHunter CHO-K1 DRD2L Beta-Arrestin cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624495
textual definition: A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (DRD2L, long form of human DRD2) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD2L-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.
term editor: BAO, YH
definition source: https://www.discoverx.com/products/cell-line/cho-k1-drd2l-beta-arrestin-cell-line-93-0579c2
imported from: clo.owl
see also: BAO: BAO_0030056

PathHunter CHO-K1 DRD3 Beta-Arrestin cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624500
textual definition: A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (human DRD3) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD3-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.
term editor: BAO, YH
definition source: https://www.discoverx.com/products/cell-line/cho-k1-drd3-beta-arrestin-cell-line-93-0591c2
imported from: clo.owl
see also: BAO: BAO_0030057

RAW-Blue cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 652166
textual definition: RAW-Blue cells are derived from the murine RAW 264.7 macrophages with chromosomal integration of a secreted embryonic alkaline phosphatase (SEAP) reporter construct inducible by NF-κB and AP-1.
term editor: BAO, YH
definition source: http://web.expasy.org/cellosaurus/CVCL_X594
definition source: http://www.invivogen.com/raw-blue
imported from: clo.owl
see also: BAO: BAO_0030060

S16 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624032
textual definition: A rat immortilized Schwann cell line.
alternative term: S-16 cell
definition source: http://purl.obolibrary.org/obo/BTO_0002937
definition source: http://web.expasy.org/cellosaurus/CVCL_B072
imported from: clo.owl
see also: BAO: BAO_0030061
see also: BTO: BTO_0002937

SW1 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 1355
textual definition: A mouse melanoma cell line (which harbors N-Ras mutation), isolated from a small amelanotic lung metastasis in a mouse with a s.c. K-1735 tumor.
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158838/
definition source: http://www.ncbi.nlm.nih.gov/pubmed/2832058/
imported from: clo.owl
see also: BAO: BAO_0030062

Tango cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 485366
textual definition: 'Tango cell' refers to one of many stable cell lines, all based on the parental line HEK293T, designed to work in a 'Tango beta-arrestin' recruitiment assay to measure receptor activation for more than 300 GPCRs. See PMID25895059 and https://pdspdb.unc.edu/prestotango/
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/25895059
definition source: https://pdspdb.unc.edu/prestotango/
definition source: https://www.ncbi.nlm.nih.gov/pubmed/18165312
imported from: clo.owl
see also: BTO: BAO_0030063

TMD8 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651712
textual definition: Human diffuse large B cell lymphoma cell line derived from a 62-year-old male patient
term editor: BAO, YH
definition source: http://web.expasy.org/cellosaurus/CVCL_A442
imported from: clo.owl
see also: BAO: BAO_0030064

U87-EGFRvIII cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 504935
textual definition: U87-EGFRvIII (aka U87/vIII) is a stable cell line derived from U87MG (a human glioblastoma) to overexpress the most common mutation of epidermal growth factor receptor (EGFR) found in human glioblastomas--an in-frame deletion of an 801-bp sequence in the extracellular domain of EGFR termed EGFRvIII. (descr. in PMID 15548697).
term editor: BAO, YH
alternative term: U87/vIII
definition source: http://www.ncbi.nlm.nih.gov/pubmed/15548697/
imported from: clo.owl
see also: BAO: BAO_0030059

MDCK-II cell
type: Class
subclass of: immortal cell line cell
alternative term: MDCK-I
definition source: https://pubmed.ncbi.nlm.nih.gov/21982418/
definition source: https://www.cellosaurus.org/CVCL_0424
imported from: clo.owl
alternative term: MDCK II
alternative term: MDCK Type II
alternative term: MDCK-2
alternative term: MDCK2
alternative term: MDCKII
alternative term: MDCKII-WT
see also: BTO; BTO:0004607
see also: ChEMBL-Cells; CHEMBL3308862
see also: HyperCLDB: cl5079
see also: Wikidata; Q54904781

MDCKII-LE cell
type: Class
subclass of: immortal cell line cell
textual definition: Compared to the parent cell line, has a lower expression of endogenous ABCB1/MDR1.
alternative term: MDCKII-LE
alternative term: RRCK
alternative term: Ralph Russ Canine Kidney
definition source: https://pubmed.ncbi.nlm.nih.gov/21766308/
definition source: https://www.cellosaurus.org/CVCL_VR40
imported from: clo.owl
alternative term: MDCKII-Low Efflux
see also: Wikidata; Q95987829

disease of metabolism
type: Class
subclass of: disease
textual definition: A disease that involving errors in metabolic processes of building or degradation of molecules.
imported from: doid.owl
has cross-reference: ICD10CM:E88.9
has cross-reference: ICD9CM:277.9
has cross-reference: MESH:D008659
has cross-reference: NCI:C3235
has cross-reference: SNOMEDCT_US_2020_03_01:75934005
has cross-reference: UMLS_CUI:C0025517
alternative_term: metabolic disease
has_obo_namespace: disease_ontology
id: DOID:0014667
in subset: DO AGR slim
in subset: DO GXD slim
in subset: NCIthesaurus

chikungunya
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.
imported from: doid.owl
has cross-reference: GARD:6038
alternative_term: Chikungunya fever
has_obo_namespace: disease_ontology
id: DOID:0050012
in subset: zoonotic infectious disease

carbohydrate metabolism disease
type: Class
subclass of: acquired metabolic disease
textual definition: An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050013
in subset: DO FlyBase slim

human granulocytic anaplasmosis
type: Class
subclass of: ehrlichiosis
textual definition: An ehrlichiosis that results in infection located in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted by lone start tick (Amblyomma americanum ). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.
imported from: doid.owl
has_alternative_id: DOID:0050021
has_alternative_id: DOID:0050022
alternative_term: human granulocytic ehrlichiosis
has_obo_namespace: disease_ontology
has_related_synonym: HGE
id: DOID:0050025
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease

human monocytic ehrlichiosis
type: Class
subclass of: ehrlichiosis
textual definition: An ehrlichiosis that results in infection located in monocyte or located in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted by black-legged tick (Ixodes scapularis), transmitted by western black-legged tick (Ixodes pacificus) or transmitted by castor bean tick (Ixodes ricinus). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.
imported from: doid.owl
has_alternative_id: DOID:14091
has cross-reference: GARD:72
has_obo_namespace: disease_ontology
has_related_synonym: Ehrlichiosis chafeensis
id: DOID:0050026
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease

mineral metabolism disease
type: Class
subclass of: acquired metabolic disease
textual definition: An acquired metabolic disease that is characterized by abnormal mineral metabolism.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050032

African tick-bite fever
type: Class
subclass of: spotted fever
textual definition: A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash.
imported from: doid.owl
has_alternative_id: DOID:0050034
has_alternative_id: DOID:0050036
alternative_term: Rickettsia africae spotted fever
alternative_term: south african tick-bite fever
has_obo_namespace: disease_ontology
id: DOID:0050035
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

Far Eastern spotted fever
type: Class
subclass of: spotted fever
textual definition: A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy.
imported from: doid.owl
alternative_term: Rickettsia heilongjiangensis spotted fever
has_obo_namespace: disease_ontology
id: DOID:0050046
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

Japanese spotted fever
type: Class
subclass of: spotted fever
textual definition: A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities.
imported from: doid.owl
has_alternative_id: DOID:0050049
alternative_term: Rickettsia japonica spotted fever
alternative_term: oriental spotted fever
has_obo_namespace: disease_ontology
id: DOID:0050050
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

erysipeloid
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.
imported from: doid.owl
has cross-reference: MESH:D004887
has_obo_namespace: disease_ontology
id: DOID:0050061
in subset: gram-positive bacterial infectious disease
in subset: zoonotic infectious disease

adiaspiromycosis
type: Class
subclass of: primary systemic mycosis
subclass of: skin disease
subclass of: lung disease
textual definition: A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050072

invasive aspergillosis
type: Class
subclass of: aspergillosis
subclass of: lung disease
textual definition: An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050073

Keshan disease
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency that is disease characterized by a cardiomyopathy secondary to selenium deficiency.
imported from: doid.owl
has cross-reference: GARD:8761
has_obo_namespace: disease_ontology
id: DOID:0050083

disease by infectious agent
type: Class
subclass of: disease
textual definition: A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.
imported from: doid.owl
IEDB alternative term: infectious disease
has_alternative_id: DOID:10115
has_alternative_id: DOID:11078
has_alternative_id: DOID:1304
has_alternative_id: DOID:1321
has_alternative_id: DOID:2040
has_alternative_id: DOID:2288
has_alternative_id: DOID:3099
has_alternative_id: DOID:4120
has_alternative_id: DOID:4620
has_alternative_id: DOID:5256
has_alternative_id: DOID:945
has_alternative_id: DOID:95
has_alternative_id: DOID:9532
has_alternative_id: DOID:9696
has cross-reference: ICD9CM:079.0
has cross-reference: UMLS_CUI:C0001485
alternative_term: infectious disease
has_obo_namespace: disease_ontology
id: DOID:0050117
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus
comment: DO:wk

La Crosse encephalitis
type: Class
subclass of: DOID 934
subclass of: DOID 936
textual definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.
imported from: doid.owl
has_alternative_id: DOID:10840
has cross-reference: ICD10CM:A83.5
has cross-reference: ICD9CM:062.5
has cross-reference: MESH:D004670
has cross-reference: SNOMEDCT_US_2020_03_01:69627004
has cross-reference: UMLS_CUI:C0014053
alternative_term: California Encephalitis
alternative_term: California virus encephalitis
alternative_term: Neuroinvasive California encephalitis virus infection
has_obo_namespace: disease_ontology
id: DOID:0050118
in subset: zoonotic infectious disease

hemophagocytic lymphohistiocytosis
type: Class
subclass of: lymphatic system disease
textual definition: A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.
imported from: doid.owl
has_alternative_id: DOID:6453
has cross-reference: GARD:6589
has cross-reference: ICD10CM:D76.1
has cross-reference: MESH:D051359
has cross-reference: NCI:C34792
has cross-reference: OMIM:PS267700
has cross-reference: ORDO:540
has cross-reference: SNOMEDCT_US_2020_03_01:190958003
has cross-reference: UMLS_CUI:C0024291
alternative_term: haemophagocytic syndrome
has_obo_namespace: disease_ontology
id: DOID:0050120
in subset: NCIthesaurus
comment: Xref MGI. MESH:C537250 added from NeuroDevNet [WAK].

sinusitis
type: Class
subclass of: paranasal sinus disease
textual definition: A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip.
imported from: doid.owl
has_alternative_id: DOID:2052
has_alternative_id: DOID:9564
has cross-reference: ICD10CM:J01
has cross-reference: ICD9CM:461
has cross-reference: NCI:C128411
has cross-reference: SNOMEDCT_US_2020_03_01:195649005
has cross-reference: UMLS_CUI:C0149512
has_obo_namespace: disease_ontology
id: DOID:0050127
in subset: NCIthesaurus

secretory diarrhea
type: Class
subclass of: diarrhea
textual definition: Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050129

superficial mycosis
type: Class
subclass of: fungal infectious disease
textual definition: A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host.
imported from: doid.owl
has_alternative_id: DOID:13370
has cross-reference: ICD10CM:B36.9
has cross-reference: MESH:D010854
has cross-reference: SNOMEDCT_US_2020_03_01:266218008
has cross-reference: SNOMEDCT_US_2020_03_01:47382004
has cross-reference: UMLS_CUI:C0031898
has cross-reference: UMLS_CUI:C2980104
alternative_term: Steroid-modified tinea infection
alternative_term: piedra
has_obo_namespace: disease_ontology
id: DOID:0050133
comment: Adding a UMLS CUI for piedra C2980104.

cutaneous mycosis
type: Class
subclass of: fungal infectious disease
textual definition: A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050134

subcutaneous mycosis
type: Class
subclass of: fungal infectious disease
subclass of: skin disease
textual definition: A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050135

systemic mycosis
type: Class
subclass of: fungal infectious disease
textual definition: A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050136

acute diarrhea
type: Class
subclass of: diarrhea
textual definition: A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050140

intestinal botulism
type: Class
subclass of: botulism
textual definition: A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050141

adenoiditis
type: Class
subclass of: DOID 974
textual definition: An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.
imported from: doid.owl
has_alternative_id: DOID:13750
has cross-reference: ICD10CM:J35.02
has cross-reference: ICD9CM:474.01
has cross-reference: SNOMEDCT_US_2020_03_01:195794009
has cross-reference: UMLS_CUI:C0396023
alternative_term: chronic adenoiditis
has_obo_namespace: disease_ontology
id: DOID:0050145

otomycosis
type: Class
subclass of: DOID 9463
textual definition: An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.
imported from: doid.owl
has cross-reference: MESH:D059249
alternative_term: Singapore ear
has_obo_namespace: disease_ontology
id: DOID:0050147

laryngotracheitis
type: Class
subclass of: DOID 974
textual definition: An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.
imported from: doid.owl
has_alternative_id: DOID:11795
has_alternative_id: DOID:9390
has cross-reference: ICD10CM:J04
has cross-reference: ICD10CM:J37.1
has cross-reference: ICD9CM:464
has cross-reference: ICD9CM:476.1
has cross-reference: SNOMEDCT_US_2020_03_01:276443001
has cross-reference: SNOMEDCT_US_2020_03_01:83271005
has cross-reference: UMLS_CUI:C0155811
has cross-reference: UMLS_CUI:C0155837
has_obo_namespace: disease_ontology
id: DOID:0050148

Pontiac fever
type: Class
subclass of: legionellosis
textual definition: A legionellosis that involves a milder respiratory illness without pneumonia. Symptoms include fever, headache and muscle aches which last for 2 to 5 days.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050150
in subset: gram-negative bacterial infectious disease

aspiration pneumonia
type: Class
subclass of: DOID 874
textual definition: A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.
imported from: doid.owl
has cross-reference: ICD10CM:J69.0
has cross-reference: MESH:D011015
has cross-reference: SNOMEDCT_US_2020_03_01:47839005
has cross-reference: UMLS_CUI:C0032290
has_obo_namespace: disease_ontology
id: DOID:0050152

pulmonary aspergilloma
type: Class
subclass of: aspergillosis
subclass of: lung disease
textual definition: An aspergillosis that presents as a clump of tangled mass of Aspergillus fungus fibres, blood clots, and white blood cells, which exists in the cavities of the lungs that develop in an area of previous lung disease or lung scarring.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050153

sensory system disease
type: Class
subclass of: DOID 863
textual definition: A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050155
in subset: DO AGR slim
in subset: DO FlyBase slim
in subset: DO GXD slim

idiopathic pulmonary fibrosis
type: Class
subclass of: pulmonary fibrosis
textual definition: A pulmonary fibrosis that is characterized by scarring of the lung.
imported from: doid.owl
has cross-reference: EFO:0000768
has cross-reference: GARD:8609
has cross-reference: ICD10CM:J84.112
has cross-reference: ICD9CM:516.31
has cross-reference: MESH:D054990
has cross-reference: NCI:C35716
has cross-reference: OMIM:178500
has cross-reference: SNOMEDCT_US_2020_03_01:28168000
has cross-reference: UMLS_CUI:C1800706
alternative_term: FIBROCYSTIC PULMONARY DYSPLASIA
alternative_term: IDIOPATHIC PULMONARY FIBROSIS, FAMILIAL
alternative_term: cryptogenic fibrosing alveolitis
has_obo_namespace: disease_ontology
id: DOID:0050156
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cryptogenic organizing pneumonia
type: Class
subclass of: idiopathic interstitial pneumonia
textual definition: An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.
imported from: doid.owl
has_alternative_id: DOID:2798
has cross-reference: GARD:1620
has cross-reference: ICD10CM:J84.116
has cross-reference: ICD9CM:516.36
has cross-reference: MESH:D018549
has cross-reference: NCI:C62586
has cross-reference: SNOMEDCT_US_2020_03_01:129458007
has cross-reference: UMLS_CUI:C0242770
alternative_term: BOOP
alternative_term: Cryptogenic organising pneumonitis
alternative_term: Cryptogenic organizing pneumonitis
alternative_term: bronchiolitis obliterans organising pneumonia
alternative_term: bronchiolitis obliterans organizing pneumonia
alternative_term: cryptogenic organising pneumonia
alternative_term: idiopathic bronchiolitis obliterans with organising pneumonia
alternative_term: idiopathic bronchiolitis obliterans with organizing pneumonia
has_obo_namespace: disease_ontology
id: DOID:0050157
in subset: NCIthesaurus

inhalation anthrax
type: Class
subclass of: anthrax disease
textual definition: An anthrax disease that results in infection located in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches.
imported from: doid.owl
alternative_term: pulmonary anthrax
alternative_term: respiratory anthrax
alternative_term: wool-sorters' disease
alternative_term: woolsorters' disease
has_obo_namespace: disease_ontology
id: DOID:0050160
in subset: gram-positive bacterial infectious disease
in subset: zoonotic infectious disease

lower respiratory tract disease
type: Class
subclass of: respiratory system disease
textual definition: A respiratory system disease which involves the lower respiratory tract.
imported from: doid.owl
has cross-reference: ICD9CM:478.19
has cross-reference: SNOMEDCT_US_2020_03_01:195823002
has cross-reference: UMLS_CUI:C0029581
has_obo_namespace: disease_ontology
id: DOID:0050161

autoimmune polyendocrine syndrome type 1
type: Class
subclass of: autoimmune polyendocrine syndrome
textual definition: An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.
imported from: doid.owl
has cross-reference: GARD:8466
has cross-reference: OMIM:240300
alternative_term: Autoimmune Polyglandular Syndrome I
alternative_term: Whitaker syndrome
alternative_term: autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
has_obo_namespace: disease_ontology
id: DOID:0050167

autoimmune polyendocrine syndrome type 2
type: Class
subclass of: autoimmune polyendocrine syndrome
textual definition: An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene.
imported from: doid.owl
has cross-reference: GARD:7611
has cross-reference: OMIM:269200
alternative_term: Schmidt syndrome
has_obo_namespace: disease_ontology
id: DOID:0050168

cutaneous lupus erythematosus
type: Class
subclass of: skin disease
subclass of: DOID 8857
textual definition: A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight.
imported from: doid.owl
has cross-reference: GARD:6225
has_obo_namespace: disease_ontology
id: DOID:0050169

tick-borne encephalitis
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.
imported from: doid.owl
has_alternative_id: DOID:0050176
has_alternative_id: DOID:10251
has_alternative_id: DOID:10252
has cross-reference: GARD:5216
has cross-reference: ICD10CM:A84.1
has cross-reference: ICD9CM:063.2
has cross-reference: MESH:D004675
has cross-reference: SNOMEDCT_US_2020_03_01:16901001
has cross-reference: UMLS_CUI:C0014054
alternative_term: Central European encephalitis
alternative_term: Far Eastern TBE
alternative_term: Russian spring-summer encephalitis
alternative_term: Siberian tick-borne encephalitis
alternative_term: Taiga encephalitis
alternative_term: Western European tick-borne encephalitis
alternative_term: west-Siberian encephalitis
has_obo_namespace: disease_ontology
id: DOID:0050175
in subset: tick-borne infectious disease

monogenic disease
type: Class
subclass of: genetic disease
textual definition: A genetic disease that is the result of one or more abnormal alleles and may be dominant, semi-dominant, or recessive.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050177
in subset: DO AGR slim
in subset: DO GXD slim

erythema multiforme
type: Class
subclass of: allergic disease
subclass of: skin disease
textual definition: A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness.
imported from: doid.owl
has cross-reference: GARD:6372
has cross-reference: MESH:D004892
has_obo_namespace: disease_ontology
id: DOID:0050185

Argentine hemorrhagic fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050194
in subset: zoonotic infectious disease

Venezuelan hemorrhagic fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050196
in subset: zoonotic infectious disease

Korean hemorrhagic fever
type: Class
subclass of: Hantavirus hemorrhagic fever with renal syndrome
textual definition: A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050200
in subset: zoonotic infectious disease

Lambert-Eaton myasthenic syndrome
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: autoimmune disease of peripheral nervous system
subclass of: neuromuscular junction disease
textual definition: A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal.
imported from: doid.owl
has cross-reference: ICD10CM:G70.80
has cross-reference: ICD9CM:358.3
has cross-reference: MESH:D015624
has cross-reference: NCI:C3155
has cross-reference: SNOMEDCT_US_2020_03_01:230688006
has cross-reference: UMLS_CUI:C0022972
alternative_term: Eaton-Lambert syndrome
alternative_term: LEMS
alternative_term: Lambert-Eaton syndrome
has_obo_namespace: disease_ontology
id: DOID:0050214
in subset: NCIthesaurus

primary amebic meningoencephalitis
type: Class
subclass of: parasitic protozoa infectious disease
subclass of: central nervous system disease
textual definition: A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.
imported from: doid.owl
has cross-reference: GARD:9554
alternative_term: Naegleria fowleri infection
has_obo_namespace: disease_ontology
id: DOID:0050242

granulomatous amebic encephalitis
type: Class
subclass of: primary amebic meningoencephalitis
subclass of: DOID 936
textual definition: A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.
imported from: doid.owl
has cross-reference: GARD:12651
alternative_term: Acanthamoeba encephalitis
alternative_term: Acanthamoeba granulomatous encephalitis
alternative_term: Granulomatous Amebic Encephalitis due to Acanthamoeba
alternative_term: granulomatous amoebic encephalitis
has_obo_namespace: disease_ontology
id: DOID:0050246

angiostrongyliasis
type: Class
subclass of: central nervous system disease
subclass of: intestinal disease
subclass of: eye disease
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis.
imported from: doid.owl
has cross-reference: GARD:683
has_obo_namespace: disease_ontology
id: DOID:0050256

tungiasis
type: Class
subclass of: parasitic ectoparasitic infectious disease
textual definition: A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.
imported from: doid.owl
has cross-reference: GARD:393
has cross-reference: MESH:D058285
has_obo_namespace: disease_ontology
id: DOID:0050266

ophthalmomyiasis
type: Class
subclass of: myiasis
subclass of: eye disease
textual definition: A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050268

conidiobolomycosis
type: Class
subclass of: subcutaneous mycosis
textual definition: An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050279

fusariosis
type: Class
subclass of: opportunistic mycosis
textual definition: An opportunistic mycosis that involves localized or hematogenously disseminated fungal infection by Fusarium solani or Fusarium oxysporum. Skin lesions are seen in neutropenic patients, and indolent cellulitis or soft-tissue necrosis occur in immunocompromised patients at the site of trauma.
imported from: doid.owl
has cross-reference: MESH:D060585
has_obo_namespace: disease_ontology
id: DOID:0050289

trichosporonosis
type: Class
subclass of: opportunistic mycosis
textual definition: An opportunistic mycosis that results_in disseminated infection, has_material_basis_in Trichosporon and results_in_formation_of nontender erythematous nodules anywhere on the body.
imported from: doid.owl
has cross-reference: MESH:D060586
has_obo_namespace: disease_ontology
id: DOID:0050290

primary systemic mycosis
type: Class
subclass of: systemic mycosis
textual definition: A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050292

aniseikonia
type: Class
subclass of: DOID 9835
textual definition: A refractive error that is characterized by the significant difference in perceived sizes of an object between the two eyes.
imported from: doid.owl
has cross-reference: MESH:D000839
has_obo_namespace: disease_ontology
id: DOID:0050304

congenital hypothyroidism
type: Class
subclass of: physical disorder
subclass of: hypothyroidism
textual definition: A hypothyroidism that is present at birth.
imported from: doid.owl
has_alternative_id: DOID:11631
has_alternative_id: DOID:11632
has cross-reference: GARD:1487
has cross-reference: ICD10CM:E00.1
has cross-reference: ICD10CM:E03.1
has cross-reference: ICD9CM:243
has cross-reference: MESH:D003409
has cross-reference: NCI:C26734
has cross-reference: NCI:C98921
has cross-reference: OMIM:PS275200
has cross-reference: SNOMEDCT_US_2020_03_01:217710005
has cross-reference: SNOMEDCT_US_2020_03_01:75065003
has cross-reference: UMLS_CUI:C0010308
has cross-reference: UMLS_CUI:C0342200
has_obo_namespace: disease_ontology
id: DOID:0050328
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

LADD syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by autosomal dominant inheritance of abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.
imported from: doid.owl
has cross-reference: OMIM:149730
alternative_term: LEVY-HOLLISTER SYNDROME
alternative_term: lacrimoauriculodentodigital syndrome
has_obo_namespace: disease_ontology
id: DOID:0050331
comment: OMIM mapping confirmed by DO. [SN].

enlarged vestibular aqueduct
type: Class
subclass of: vestibular disease
textual definition: A vestibular disease that is characterized by progressive hearing loss resulting from congenital enlargement of the vestibular aqueducts.
imported from: doid.owl
has cross-reference: GARD:8651
has_obo_namespace: disease_ontology
id: DOID:0050332
comment: OMIM mapping confirmed by DO. [SN].

hypophosphatemia
type: Class
subclass of: phosphorus metabolism disease
textual definition: A phosphorus metabolism disease that is characterized by hypophosphatemia and the symptoms of osteomalacia including bone pain, skeletal deformities and osteoarthritis.
imported from: doid.owl
has cross-reference: MESH:D017674
has_obo_namespace: disease_ontology
id: DOID:0050336

primary bacterial infectious disease
type: Class
subclass of: bacterial infectious disease
textual definition: A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050338
in subset: DO FlyBase slim

commensal bacterial infectious disease
type: Class
subclass of: bacterial infectious disease
textual definition: A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050339

opportunistic bacterial infectious disease
type: Class
subclass of: bacterial infectious disease
textual definition: A bacterial infectious disease that results_in infection by bacteria in individuals whose host defense mechanisms have been compromised.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050340
in subset: DO FlyBase slim

foodborne botulism
type: Class
subclass of: botulism
textual definition: A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has symptom blurred vision, has symptom diplopia, has symptom dysarthria, has symptom dysphonia, has symptom dysphagia and has symptom descending muscle paralysis.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050352
in subset: GOLD
in subset: gram-positive bacterial infectious disease

wound botulism
type: Class
subclass of: botulism
textual definition: A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050353
in subset: gram-positive bacterial infectious disease

infant botulism
type: Class
subclass of: botulism
textual definition: A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050354
in subset: gram-positive bacterial infectious disease

Carrion's disease
type: Class
subclass of: bartonellosis
textual definition: A bartonellosis that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.
imported from: doid.owl
alternative_term: Carrion disease
alternative_term: Oroya fever
has_obo_namespace: disease_ontology
id: DOID:0050398

familial adenomatous polyposis
type: Class
subclass of: autosomal genetic disease
subclass of: intestinal disease
textual definition: An intestinal disease that has_material_basis_in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.
imported from: doid.owl
has cross-reference: GARD:6408
has cross-reference: MESH:D011125
has cross-reference: NCI:C3339
has cross-reference: OMIM:PS175100
has cross-reference: ORDO:733
has cross-reference: SNOMEDCT_US_2020_03_01:72900001
has cross-reference: UMLS_CUI:C0032580
alternative_term: adenomatous polyposis of the colon
has_obo_namespace: disease_ontology
id: DOID:0050424
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Stevens-Johnson syndrome
type: Class
subclass of: skin disease
textual definition: A skin disease that is characterized by ulceration of less than 10 percent of the surface area of the body. The disease is often precipitated by the use of medications, such as antibiotics or antiepileptics, or onset of infection.
imported from: doid.owl
has cross-reference: EFO:0004276
has cross-reference: GARD:7700
has cross-reference: ICD10CM:L51.1
has cross-reference: ICD9CM:695.13
has cross-reference: NCI:C79484
has cross-reference: NCI:C79777
has cross-reference: SNOMEDCT_US_2020_03_01:73442001
has cross-reference: UMLS_CUI:C0038325
has_obo_namespace: disease_ontology
id: DOID:0050426
in subset: NCIthesaurus

xeroderma pigmentosum
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair.
imported from: doid.owl
has cross-reference: GARD:7910
has cross-reference: ICD10CM:Q82.1
has cross-reference: MESH:D014983
has cross-reference: NCI:C3452
has cross-reference: ORDO:910
has cross-reference: SNOMEDCT_US_2020_03_01:44600005
has cross-reference: UMLS_CUI:C0043346
has_obo_namespace: disease_ontology
id: DOID:0050427
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

nonepidermolytic palmoplantar keratoderma
type: Class
subclass of: palmoplantar keratosis
textual definition: A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles.
imported from: doid.owl
has cross-reference: MESH:D015776
has cross-reference: NCI:C3147
has cross-reference: OMIM:600962
has cross-reference: OMIM:613000
has cross-reference: OMIM:615735
has cross-reference: ORDO:2337
has cross-reference: SNOMEDCT_US_2020_03_01:81206005
has cross-reference: UMLS_CUI:C0022584
has cross-reference: UMLS_CUI:C3489771
alternative_term: Thost-Unna Syndrome
alternative_term: Unna-Thost Syndrome
alternative_term: diffuse nonepidermolytic palmomplantar keratoderma
alternative_term: tylosis
has_obo_namespace: disease_ontology
id: DOID:0050428
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Hailey-Hailey disease
type: Class
subclass of: autosomal dominant disease
subclass of: DOID 9182
textual definition: A pemphigus that is characterized by recurring blistering most commonly occurring in the folds of the skin and has_material_basis_in mutations in the ATP2C1 gene that result in loss of adhesion within the skin.
imported from: doid.owl
has cross-reference: GARD:6559
has cross-reference: ICD10CM:Q82.8
has cross-reference: MESH:D016506
has cross-reference: NCI:C82865
has cross-reference: OMIM:169600
has cross-reference: SNOMEDCT_US_2020_03_01:79468000
has cross-reference: UMLS_CUI:C0085106
alternative_term: BENIGN CHRONIC PEMPHIGUS
alternative_term: Pemphigus, Benign Familial
has_obo_namespace: disease_ontology
id: DOID:0050429
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

multiple endocrine neoplasia type 2A
type: Class
subclass of: autosomal dominant disease
subclass of: multiple endocrine neoplasia
textual definition: A multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis.
imported from: doid.owl
has cross-reference: ICD10CM:E31.22
has cross-reference: ICD9CM:258.02
has cross-reference: MESH:D018813
has cross-reference: NCI:C3226
has cross-reference: OMIM:171400
has cross-reference: ORDO:247698
has cross-reference: SNOMEDCT_US_2020_03_01:721188000
has cross-reference: UMLS_CUI:C0025268
alternative_term: MEN2A
alternative_term: Sipple syndrome
alternative_term: multiple endocrine neoplasia II
has_obo_namespace: disease_ontology
id: DOID:0050430
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

arrhythmogenic right ventricular cardiomyopathy
type: Class
subclass of: intrinsic cardiomyopathy
textual definition: An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle.
imported from: doid.owl
has cross-reference: MESH:D019571
has cross-reference: NCI:C84571
has cross-reference: OMIM:PS107970
has cross-reference: ORDO:217656
has cross-reference: ORDO:247
has cross-reference: SNOMEDCT_US_2020_03_01:281170005
has cross-reference: UMLS_CUI:C0349788
alternative_term: ARVC
alternative_term: ARVC cardiomyopathy
alternative_term: ARVD
alternative_term: arrhythmogenic right ventricular dysplasia
alternative_term: arrhythmogenic right ventricular dysplasia/cardiomyopathy
has_obo_namespace: disease_ontology
id: DOID:0050431
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Asperger syndrome
type: Class
subclass of: autism spectrum disorder
textual definition: An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.
imported from: doid.owl
has cross-reference: GARD:5855
has cross-reference: ICD10CM:F84.5
has cross-reference: MESH:D020817
has cross-reference: NCI:C97159
has cross-reference: OMIM:608631
has cross-reference: OMIM:608638
has cross-reference: OMIM:608781
has cross-reference: OMIM:609954
has cross-reference: ORDO:1162
has cross-reference: SNOMEDCT_US_2020_03_01:154879004
has cross-reference: UMLS_CUI:C0236792
has_obo_namespace: disease_ontology
id: DOID:0050432
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

fatal familial insomnia
type: Class
subclass of: prion disease
textual definition: A prion disease that is characterized by insomnia, hallucinations, dementia and death, located_in the brain.
imported from: doid.owl
has cross-reference: GARD:6429
has cross-reference: ICD10CM:A81.83
has cross-reference: ICD9CM:046.72
has cross-reference: MESH:D034062
has cross-reference: NCI:C84711
has cross-reference: OMIM:600072
has cross-reference: SNOMEDCT_US_2020_03_01:83157008
has cross-reference: UMLS_CUI:C0206042
has_obo_namespace: disease_ontology
id: DOID:0050433
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mulibrey nanism
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by global growth retardation of the muscle, liver, brain and eyes as well as constrictive pericarditis and has_material_basis_in mutations in the TRIM37 gene.
imported from: doid.owl
has cross-reference: GARD:95
has cross-reference: MESH:D050336
has cross-reference: NCI:C84906
has cross-reference: OMIM:253250
has cross-reference: ORDO:2576
has cross-reference: SNOMEDCT_US_2020_03_01:81604003
has cross-reference: UMLS_CUI:C0524582
alternative_term: MUL
alternative_term: Mulibrey growth disorder
alternative_term: Muscle-Liver-Brain-Eye Nanism
alternative_term: PERICARDIAL CONSTRICTION AND GROWTH FAILURE
alternative_term: Perheentupa Syndrome
has_obo_namespace: disease_ontology
id: DOID:0050436
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Danon disease
type: Class
subclass of: X-linked dominant disease
subclass of: lysosomal storage disease
textual definition: A lysosomal storage disease that is characterized by cardiomyopathy, skeletal myopathy and intellectual disability and has_material_basis_in mutations in the LAMP2 gene.
imported from: doid.owl
has cross-reference: GARD:9730
has cross-reference: MESH:D052120
has cross-reference: NCI:C84735
has cross-reference: OMIM:300257
has cross-reference: SNOMEDCT_US_2020_03_01:419097006
has cross-reference: UMLS_CUI:C0878677
alternative_term: ANTOPOL DISEASE
alternative_term: PSEUDOGLYCOGENOSIS II
has_obo_namespace: disease_ontology
id: DOID:0050437
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Frasier syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by gonadal dysgenesis, streak gonads, progressive focal segmental glomerulonephropathy and the development of urogenital cancers that is the result of mutation in the WT1 gene.
imported from: doid.owl
has cross-reference: GARD:2375
has cross-reference: MESH:D052159
has cross-reference: NCI:C122805
has cross-reference: OMIM:136680
has cross-reference: SNOMEDCT_US_2020_03_01:445431000
has cross-reference: UMLS_CUI:C0950122
has_obo_namespace: disease_ontology
id: DOID:0050438
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Usher syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by a combination of hearing loss and visual impairment.
imported from: doid.owl
has cross-reference: GARD:7843
has cross-reference: MESH:D052245
has cross-reference: NCI:C85217
has cross-reference: OMIM:PS276900
has cross-reference: ORDO:886
has cross-reference: SNOMEDCT_US_2020_03_01:57838006
has cross-reference: UMLS_CUI:C0271097
has_obo_namespace: disease_ontology
id: DOID:0050439
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [LS].

mucosulfatidosis
type: Class
subclass of: autosomal recessive disease
subclass of: sphingolipidosis
textual definition: A sphingolipidosis that is characterized by leukodystrophy, ichthyosis, skeletal abnormalities and shortened life expectancy and has_material_basis_in mutation in the SUMF1 gene that results in deficiency in multiple sulfatase enzymes.
imported from: doid.owl
has cross-reference: ICD10CM:E75.26
has cross-reference: MESH:D052517
has cross-reference: NCI:C84908
has cross-reference: OMIM:272200
has cross-reference: SNOMEDCT_US_2020_03_01:254076009
has cross-reference: SNOMEDCT_US_2020_03_01:54898003
has cross-reference: UMLS_CUI:C0268263
has cross-reference: UMLS_CUI:C1720864
alternative_term: Sulfatidosis, Juvenile, Austin Type
alternative_term: multiple sulfatase deficiency disease
has_obo_namespace: disease_ontology
id: DOID:0050441
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

infantile Refsum disease
type: Class
subclass of: DOID 906
textual definition: A peroxisomal disease that is characterized by neurological impairment, intellectual disability, hepatosplenomegaly and ichthyosis and results from the accumulation of very long chain fatty acids and phytanic acid, secondary to mutation in the PEX genes.
imported from: doid.owl
has cross-reference: ICD10CM:G60.1
has cross-reference: MESH:D052919
has cross-reference: NCI:C84789
has cross-reference: OMIM:266510
has cross-reference: SNOMEDCT_US_2020_03_01:238062008
has cross-reference: UMLS_CUI:C0282527
alternative_term: infantile phytanic acid storage disease
has_obo_namespace: disease_ontology
id: DOID:0050444
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

X-linked dominant hypophosphatemic rickets
type: Class
subclass of: X-linked dominant disease
subclass of: rickets
textual definition: A rickets has_material_basis in X-linked mutations in the PHEX gene that lead to increased circulating levels of FGF-23, a phosphate-regulating hormone (phosphatonin), that leads to reduced renal phosphate reabsorption and consequently abnormal bone mineralization.
imported from: doid.owl
has cross-reference: MESH:D053098
has cross-reference: NCI:C123265
has cross-reference: NCI:C85234
has cross-reference: OMIM:307800
has cross-reference: UMLS_CUI:C0733682
has cross-reference: UMLS_CUI:C1845168
has cross-reference: UMLS_CUI:C3540852
alternative_term: Hypophosphatemia, Vitamin D-Resistant Rickets
alternative_term: Vitamin D-Resistant Rickets, X-Linked
alternative_term: X-linked hypophosphatemia
alternative_term: hypophosphatemic rickets X-linked dominant
has_obo_namespace: disease_ontology
id: DOID:0050445
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hereditary mucosal leukokeratosis
type: Class
subclass of: skin disease
textual definition: A skin disease characterized by a defect in the normal process of keratinization of the mucosa.
imported from: doid.owl
has cross-reference: MESH:D053529
has cross-reference: NCI:C84760
has cross-reference: OMIM:193900
has cross-reference: OMIM:615785
has cross-reference: ORDO:171723
has cross-reference: SNOMEDCT_US_2020_03_01:85388002
has cross-reference: UMLS_CUI:C1721005
alternative_term: white sponge nevus
alternative_term: white sponge nevus of Cannon
has_obo_namespace: disease_ontology
id: DOID:0050448
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

pachyonychia congenita
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by hypertrophic nails and hyperkeratosis of the hands and feet and has_material_basis in gene mutations that result in changes in keratin.
imported from: doid.owl
has cross-reference: GARD:10753
has cross-reference: MESH:D053549
has cross-reference: NCI:C84986
has cross-reference: OMIM:PS167200
has cross-reference: ORDO:2309
has cross-reference: SNOMEDCT_US_2020_03_01:39427000
has cross-reference: UMLS_CUI:C0265334
has cross-reference: UMLS_CUI:C1706595
has cross-reference: UMLS_CUI:C1721007
alternative_term: Jackson-Lawler Type Pachyonychia Congenita
alternative_term: Jadassohn-Lewandowsky Syndrome
alternative_term: PACHYONYCHIA CONGENITA, JADASSOHN-LEWANDOWSKY TYPE
alternative_term: Pachyonychia Congenita Type 1
has_obo_namespace: disease_ontology
id: DOID:0050449
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Gitelman syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: renal tubular transport disease
textual definition: A renal tubular transport disease that is has_material_basis_in mutations in genes that produce proteins involved in the kidneys' reabsorption of salt (sodium chloride or NaCl) from urine back into the bloodstream, thus impairing the kidneys' ability to reabsorb salt, leading to the loss of excess salt in the urine (salt wasting).
imported from: doid.owl
has cross-reference: GARD:8547
has cross-reference: MESH:D053579
has cross-reference: NCI:C84730
has cross-reference: OMIM:263800
has cross-reference: SNOMEDCT_US_2020_03_01:3188003
has cross-reference: UMLS_CUI:C0268450
alternative_term: HYPOMAGNESEMIA-HYPOKALEMIA, PRIMARY RENOTUBULAR, WITH HYPOCALCIURIA
has_obo_namespace: disease_ontology
id: DOID:0050450
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Brugada syndrome
type: Class
subclass of: monogenic disease
subclass of: heart conduction disease
textual definition: A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death.
imported from: doid.owl
has cross-reference: GARD:1030
has cross-reference: ICD10CM:I49.8
has cross-reference: MESH:D053840
has cross-reference: NCI:C142891
has cross-reference: OMIM:PS601144
has cross-reference: ORDO:130
has cross-reference: SNOMEDCT_US_2020_03_01:418818005
has cross-reference: UMLS_CUI:C1142166
has cross-reference: UMLS_CUI:C1721096
alternative_term: Bangungut
alternative_term: Brugada type idiopathic ventricular fibrillation
alternative_term: Dream disease
alternative_term: Pokkuri death syndrome
alternative_term: SUNDS
alternative_term: sudden unexplained nocturnal death syndrome
has_obo_namespace: disease_ontology
id: DOID:0050451
comment: OMIM mapping confirmed by DO. [SN].

mevalonic aciduria
type: Class
subclass of: genetic disease
subclass of: DOID 906
textual definition: A peroxisomal disease that is characterized by cortical atrophy, microcephaly, dysmorphic facies, muscular hypotonia and intellectual disability and has_material_basis_in mutation in the MVK gene that results in deficiency of mevalonate kinase and impaired cholesterol. biosynthesis.
imported from: doid.owl
has cross-reference: GARD:3588
has cross-reference: ICD10CM:M04.1
has cross-reference: MESH:D054078
has cross-reference: NCI:C84890
has cross-reference: OMIM:610377
has cross-reference: ORDO:29
has cross-reference: SNOMEDCT_US_2020_03_01:124327008
has cross-reference: SNOMEDCT_US_2020_03_01:234538002
has cross-reference: UMLS_CUI:C0342731
has cross-reference: UMLS_CUI:C0398691
has cross-reference: UMLS_CUI:C1959626
alternative_term: Mevalonate Kinase Deficiency
has_obo_namespace: disease_ontology
id: DOID:0050452
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

lissencephaly
type: Class
subclass of: congenital nervous system abnormality
textual definition: A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation.
imported from: doid.owl
has cross-reference: GARD:12291
has cross-reference: ICD10CM:Q04.3
has cross-reference: MESH:D054082
has cross-reference: NCI:C103921
has cross-reference: OMIM:300067
has cross-reference: OMIM:300215
has cross-reference: OMIM:607432
has cross-reference: OMIM:611603
has cross-reference: OMIM:614019
has cross-reference: OMIM:615191
has cross-reference: ORDO:102009
has cross-reference: SNOMEDCT_US_2020_03_01:204036008
has cross-reference: SNOMEDCT_US_2020_03_01:23024003
has cross-reference: UMLS_CUI:C0266463
has cross-reference: UMLS_CUI:C0266483
has_obo_namespace: disease_ontology
id: DOID:0050453
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

periventricular nodular heterotopia
type: Class
subclass of: congenital nervous system abnormality
textual definition: A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain.
imported from: doid.owl
has cross-reference: MESH:D054091
has cross-reference: OMIM:300049
has cross-reference: OMIM:608097
has cross-reference: OMIM:608098
has cross-reference: OMIM:612881
has cross-reference: OMIM:615544
has cross-reference: ORDO:98892
has cross-reference: SNOMEDCT_US_2020_03_01:448227009
has cross-reference: SNOMEDCT_US_2020_03_01:816068000
has cross-reference: UMLS_CUI:C1848213
has cross-reference: UMLS_CUI:C1868720
alternative_term: periventricular heterotopia
has_obo_namespace: disease_ontology
id: DOID:0050454
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Buruli ulcer disease
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.
imported from: doid.owl
has cross-reference: GARD:9520
has cross-reference: ICD10CM:A31.1
has cross-reference: MESH:D054312
has cross-reference: NCI:C84604
has cross-reference: SNOMEDCT_US_2020_03_01:186343005
has cross-reference: UMLS_CUI:C0085568
alternative_term: Bairnsdale ulcer
alternative_term: Daintree ulcer
alternative_term: Mossman ulcer
alternative_term: Searl ulcer
alternative_term: Searle's ulcer
has_obo_namespace: disease_ontology
id: DOID:0050456
in subset: NCIthesaurus

Sertoli cell-only syndrome
type: Class
subclass of: male infertility
textual definition: A male infertility disease characterized by male sterility, has_material_basis_in azospermia without abnormal sexual development.
imported from: doid.owl
has cross-reference: GARD:8406
has cross-reference: MESH:D054331
has cross-reference: SNOMEDCT_US_2020_03_01:73465006
has cross-reference: UMLS_CUI:C1384583
alternative_term: DEL CASTILLO SYNDROME
alternative_term: Germinal Cell Aplasia
has_obo_namespace: disease_ontology
id: DOID:0050457
comment: OMIM mapping confirmed by DO. [SN].

juvenile myelomonocytic leukemia
type: Class
subclass of: myelodysplastic/myeloproliferative neoplasm
textual definition: A myelodysplastic/myeloproliferative neoplasm that is characterized by the uncontrolled growth of monocytes.
imported from: doid.owl
has cross-reference: GARD:9884
has cross-reference: ICD10CM:C93.3
has cross-reference: MESH:D054429
has cross-reference: NCI:C9233
has cross-reference: OMIM:607785
has cross-reference: SNOMEDCT_US_2020_03_01:445227008
has cross-reference: UMLS_CUI:C0349639
has_obo_namespace: disease_ontology
id: DOID:0050458
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hyperphosphatemia
type: Class
subclass of: phosphorus metabolism disease
textual definition: A phosphorus metabolism disease characterized by hyperphosphatemia and abnormal deposits of phosphate and calcium in joints and soft tissues, results from abnomral phosphorus metabolism and has_material_basis_in mutations in the FGF23, GALNT3 or KL gene.
imported from: doid.owl
has cross-reference: MESH:D054559
has cross-reference: NCI:C113750
has cross-reference: SNOMEDCT_US_2020_03_01:20165001
has cross-reference: UMLS_CUI:C0085681
has_obo_namespace: disease_ontology
id: DOID:0050459
in subset: NCIthesaurus

Wolf-Hirschhorn syndrome
type: Class
subclass of: chromosomal deletion syndrome
textual definition: A chromosomal deletion syndrome that is characterized by distinct craniofacial features, hypotonia and intellectual disability and has_material_basis_in a microdeletion of the short arm of chromosome 4.
imported from: doid.owl
has_alternative_id: DOID:6684
has cross-reference: GARD:7896
has cross-reference: ICD10CM:Q93.3
has cross-reference: MESH:D054877
has cross-reference: NCI:C35528
has cross-reference: OMIM:194190
has cross-reference: ORDO:280
has cross-reference: SNOMEDCT_US_2020_03_01:17122004
has cross-reference: UMLS_CUI:C0796117
has cross-reference: UMLS_CUI:C1956097
alternative_term: 4p deletion syndrome
alternative_term: PITT SYNDROME
alternative_term: Pitt-Rogers-Danks Syndrome
alternative_term: chromosome 4p16.3 deletion syndrome
has_obo_namespace: disease_ontology
id: DOID:0050460
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

aspartylglucosaminuria
type: Class
subclass of: lysosomal storage disease
subclass of: genetic disease
textual definition: A lysosomal storage disease that is characterized by delayed speech at 2-3 years of age, has_material_basis_in mutations in the AGA gene that result in the absence or shortage of the aspartylglucosaminidase enzyme in lysosomes, preventing the normal breakdown of glycoproteins.
imported from: doid.owl
has cross-reference: GARD:5854
has cross-reference: ICD10CM:E77.1
has cross-reference: MESH:D054880
has cross-reference: NCI:C61273
has cross-reference: OMIM:208400
has cross-reference: SNOMEDCT_US_2020_03_01:54954004
has cross-reference: UMLS_CUI:C0268225
alternative_term: aspartylglucosaminidase deficiency
alternative_term: aspartylglycosaminuria
alternative_term: glycosylasparaginase deficiency
has_obo_namespace: disease_ontology
id: DOID:0050461
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Antley-Bixler syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene.
imported from: doid.owl
has cross-reference: OMIM:201750
has cross-reference: OMIM:207410
has cross-reference: SNOMEDCT_US_2020_03_01:62964007
alternative_term: trapezoidocephaly-synostosis syndrome
has_obo_namespace: disease_ontology
id: DOID:0050462
comment: OMIM mapping confirmed by DO. [SN].

campomelic dysplasia
type: Class
subclass of: autosomal dominant disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur.
imported from: doid.owl
has cross-reference: GARD:10027
has cross-reference: MESH:D055036
has cross-reference: NCI:C120205
has cross-reference: NCI:C84609
has cross-reference: OMIM:114290
has cross-reference: ORDO:140
has cross-reference: SNOMEDCT_US_2020_03_01:74928006
has cross-reference: UMLS_CUI:C1861922
has cross-reference: UMLS_CUI:C1861923
alternative_term: Acampomelic Campomelic Dysplasia
has_obo_namespace: disease_ontology
id: DOID:0050463
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Farber lipogranulomatosis
type: Class
subclass of: DOID 9455
textual definition: A lipid storage disease that is characterized by abnormalities in swallowing, cognition, joint function, and central nervous system due to a deficiency in the enzyme ceramidase that results in sphingolipids deposition.
imported from: doid.owl
has cross-reference: GARD:6426
has cross-reference: MESH:D055577
has cross-reference: NCI:C84710
has cross-reference: OMIM:228000
has cross-reference: SNOMEDCT_US_2020_03_01:79935000
has cross-reference: UMLS_CUI:C0268255
alternative_term: Farber disease
alternative_term: N-laurylsphingosine deacylase deficiency
alternative_term: acid ceramidase deficiency
has_obo_namespace: disease_ontology
id: DOID:0050464
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Muir-Torre syndrome
type: Class
subclass of: Lynch syndrome
textual definition: A Lynch syndrome that is characterized by a propensity to develop cancers of the gastrointestinal tract, genitourinary tract, and skin that has_material_basis_in mutations in DNA mismatch repair genes.
imported from: doid.owl
has cross-reference: GARD:6821
has cross-reference: MESH:D055653
has cross-reference: NCI:C84905
has cross-reference: OMIM:158320
has cross-reference: SNOMEDCT_US_2020_03_01:403824007
has cross-reference: UMLS_CUI:C1321489
has_obo_namespace: disease_ontology
id: DOID:0050465
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Loeys-Dietz syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by increased risk of aortic aneurysm and dissection, elongated limbs, hypertelorism, bifid uvula and easy skin bruising due to mutations in TGFB3 that results in connective tissue defects.
imported from: doid.owl
has cross-reference: GARD:10788
has cross-reference: MESH:D055947
has cross-reference: NCI:C75006
has cross-reference: ORDO:60030
has cross-reference: SNOMEDCT_US_2020_03_01:446263001
has cross-reference: UMLS_CUI:C1836635
has cross-reference: UMLS_CUI:C2697932
has_obo_namespace: disease_ontology
id: DOID:0050466
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

erythrokeratodermia variabilis
type: Class
subclass of: monogenic disease
subclass of: skin disease
textual definition: A skin disease that is characterized by areas of sharply demarcated, brown hyperkeratosis and has_material_basis_in mutations in genes encoding for connexin channels proteins in the epidermis.
imported from: doid.owl
has cross-reference: MESH:D056266
has cross-reference: NCI:C84696
has cross-reference: OMIM:PS133200
has cross-reference: ORDO:317
has cross-reference: SNOMEDCT_US_2020_03_01:70041004
has cross-reference: UMLS_CUI:C0265961
has cross-reference: UMLS_CUI:C1851480
alternative_term: Erythrokeratodermia Figurata Variabilis
alternative_term: Greither Disease
has_obo_namespace: disease_ontology
id: DOID:0050467
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

yellow nail syndrome
type: Class
subclass of: syndrome
subclass of: skin disease
subclass of: nail disease
textual definition: A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached.
imported from: doid.owl
has cross-reference: GARD:184
has cross-reference: ICD10CM:L60.5
has cross-reference: MESH:D056684
has cross-reference: NCI:C85238
has cross-reference: OMIM:153300
has cross-reference: SNOMEDCT_US_2020_03_01:400211001
has cross-reference: UMLS_CUI:C0221348
has_obo_namespace: disease_ontology
id: DOID:0050468
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Costello syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: RASopathy
textual definition: A RASopathy characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays.
imported from: doid.owl
has cross-reference: GARD:1550
has cross-reference: MESH:D056685
has cross-reference: NCI:C84652
has cross-reference: OMIM:218040
has cross-reference: SNOMEDCT_US_2020_03_01:205803001
has cross-reference: UMLS_CUI:C0587248
alternative_term: FCS SYNDROME
alternative_term: Faciocutaneoskeletal Syndrome
has_obo_namespace: disease_ontology
id: DOID:0050469
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Donohue syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by protuberant and low-set ears, flaring nostrils, thick lips, enlarged secondary sex organs and overwhelming insulin resistance and has_material_basis_in mutation within the INSR gene causing abnormalities in the insulin receptor.
imported from: doid.owl
has cross-reference: MESH:D056731
has cross-reference: NCI:C131000
has cross-reference: NCI:C84676
has cross-reference: OMIM:246200
has cross-reference: ORDO:508
has cross-reference: SNOMEDCT_US_2020_03_01:111307005
has cross-reference: SNOMEDCT_US_2020_03_01:33559001
has cross-reference: UMLS_CUI:C0265344
has cross-reference: UMLS_CUI:C0271695
alternative_term: Leprechaunism
has_obo_namespace: disease_ontology
id: DOID:0050470
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Carney complex
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity.
imported from: doid.owl
has cross-reference: GARD:1119
has cross-reference: MESH:D056733
has cross-reference: NCI:C4705
has cross-reference: OMIM:160980
has cross-reference: OMIM:605244
has cross-reference: OMIM:608837
has cross-reference: ORDO:1359
has cross-reference: SNOMEDCT_US_2020_03_01:733491005
has cross-reference: UMLS_CUI:C0406810
has cross-reference: UMLS_CUI:C1854540
has cross-reference: UMLS_CUI:C2607929
alternative_term: Carney Complex, Type 1
alternative_term: Carney Complex, Type 2
alternative_term: Carney Syndrome
alternative_term: Carney complex variant
alternative_term: LAMB Syndrome
alternative_term: NAME Syndrome
has_obo_namespace: disease_ontology
id: DOID:0050471
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

monilethrix
type: Class
subclass of: autosomal dominant disease
subclass of: hair disease
textual definition: A hair disease that is characterized by short, easily broken hair that results in alopecia and has_material_basis_in mutations in genes for type II hair cortex keratins.
imported from: doid.owl
has cross-reference: GARD:93
has cross-reference: ICD10CM:Q84.1
has cross-reference: MESH:D056734
has cross-reference: NCI:C84894
has cross-reference: OMIM:158000
has cross-reference: SNOMEDCT_US_2020_03_01:69488000
has cross-reference: UMLS_CUI:C0546966
has_obo_namespace: disease_ontology
id: DOID:0050472
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Alstrom syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.
imported from: doid.owl
has cross-reference: MESH:D056769
has cross-reference: NCI:C84549
has cross-reference: OMIM:203800
has cross-reference: SNOMEDCT_US_2020_03_01:63702009
has cross-reference: UMLS_CUI:C0268425
has_obo_namespace: disease_ontology
id: DOID:0050473
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Netherton syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: skin disease
textual definition: A skin disease that is characterized by chronic skin inflammation, trichorrhexis invaginata, atopic dermatitis and has_material_basis_in mutations in the SPINK5 gene resulting in reduced capacity to inhibit serine proteases expressed in the skin.
imported from: doid.owl
has cross-reference: GARD:7182
has cross-reference: MESH:D056770
has cross-reference: NCI:C84922
has cross-reference: OMIM:256500
has cross-reference: ORDO:634
has cross-reference: SNOMEDCT_US_2020_03_01:312514006
has cross-reference: UMLS_CUI:C0265962
has_obo_namespace: disease_ontology
id: DOID:0050474
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Weill-Marchesani syndrome
type: Class
subclass of: autosomal genetic disease
subclass of: syndrome
textual definition: A syndrome characterized by short stature, bachycephaly and other facial abnormalities, brachydactyly, joint stiffness and distinctive ocular abnormalities.
imported from: doid.owl
has cross-reference: GARD:4936
has cross-reference: MESH:D056846
has cross-reference: NCI:C85226
has cross-reference: OMIM:277600
has cross-reference: OMIM:608328
has cross-reference: OMIM:613195
has cross-reference: OMIM:614819
has cross-reference: ORDO:3449
has cross-reference: SNOMEDCT_US_2020_03_01:205801004
has cross-reference: UMLS_CUI:C0265313
has cross-reference: UMLS_CUI:C1869114
has cross-reference: UMLS_CUI:C1869115
alternative_term: GEMSS syndrome
alternative_term: Marchesani-Weill Syndrome
alternative_term: Mesodermal Dysmorphodystrophy, Congenital
alternative_term: Spherophakia Brachymorphia Syndrome
alternative_term: congenital mesodermal dystrophy
has_obo_namespace: disease_ontology
id: DOID:0050475
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [LS].

Barth syndrome
type: Class
subclass of: X-linked recessive disease
subclass of: lipid metabolism disorder
textual definition: A lipid metabolism disorder that has_material_basis_in X-linked inheritance of the tafazzin gene and is characterized by decreased production of an enzyme required to produce cardiolipin.
imported from: doid.owl
has cross-reference: GARD:5890
has cross-reference: ICD10CM:E78.71
has cross-reference: MESH:D056889
has cross-reference: NCI:C84585
has cross-reference: OMIM:302060
has cross-reference: SNOMEDCT_US_2020_03_01:297231002
has cross-reference: UMLS_CUI:C0574083
alternative_term: 3-methylglutaconicaciduria type 2
alternative_term: 3-methylglutaconicaciduria type II
alternative_term: MGA Type 2
alternative_term: MGA type II
has_obo_namespace: disease_ontology
id: DOID:0050476
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Liddle syndrome
type: Class
subclass of: renal tubular transport disease
textual definition: A renal tubular transport disease that is characterized by hypertension and hypokalemia caused by dysregulation of epithelial sodium channels causing over expression of the channel.
imported from: doid.owl
has cross-reference: GARD:7381
has cross-reference: MESH:D056929
has cross-reference: NCI:C84827
has cross-reference: OMIM:177200
has cross-reference: SNOMEDCT_US_2020_03_01:707749005
has cross-reference: UMLS_CUI:C0221043
alternative_term: Liddle's syndrome
alternative_term: Pseudoaldosteronism
has_obo_namespace: disease_ontology
id: DOID:0050477
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

endemic typhus
type: Class
subclass of: typhus
textual definition: A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash.
imported from: doid.owl
has_alternative_id: DOID:0050028
has_alternative_id: DOID:0050029
has_alternative_id: DOID:0050030
has_alternative_id: DOID:0050057
has_alternative_id: DOID:0050058
alternative_term: Rat-Flea Typhus
alternative_term: Rickettsia felis spotted fever
alternative_term: Urban Typhus of Malaya
alternative_term: cat flea rickettsiosis
alternative_term: fleaborne typhus
alternative_term: murine typhus
alternative_term: toulon typhus
alternative_term: urban typhus
has_obo_namespace: disease_ontology
has_related_synonym: Shop typhus
id: DOID:0050481
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

sennetsu fever
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.
imported from: doid.owl
has cross-reference: GARD:120
alternative_term: Sennetsu ehrlichiosis
has_obo_namespace: disease_ontology
id: DOID:0050485
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

exanthem
type: Class
subclass of: skin disease
textual definition: A skin disease that is characterized by a rash that results from a variety of causes including bacteria, viruses, toxins, drugs and autoimmune disorders.
imported from: doid.owl
has cross-reference: ICD10CM:R21
has cross-reference: ICD9CM:782.1
has cross-reference: MESH:D005076
has cross-reference: NCI:C111884
has cross-reference: SNOMEDCT_US_2020_03_01:112625008
has cross-reference: UMLS_CUI:C0015230
alternative_term: Rash
alternative_term: exanthema
has_obo_namespace: disease_ontology
id: DOID:0050486
in subset: NCIthesaurus

exanthema subitum
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.
imported from: doid.owl
has cross-reference: ICD10CM:B08.2
has cross-reference: ICD9CM:058.1
has cross-reference: MESH:D005077
has cross-reference: SNOMEDCT_US_2020_03_01:54385001
has cross-reference: UMLS_CUI:C0015231
alternative_term: Roseola Infantum
alternative_term: Sixth Disease
has_obo_namespace: disease_ontology
id: DOID:0050495

adult T-cell leukemia
type: Class
subclass of: T-cell lymphoblastic leukemia/lymphoma
subclass of: DOID 934
textual definition: A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions.
imported from: doid.owl
has cross-reference: GARD:13103
has cross-reference: ICD10CM:C91.5
has cross-reference: MESH:D015459
has cross-reference: NCI:C3184
has cross-reference: SNOMEDCT_US_2020_03_01:77430005
has cross-reference: UMLS_CUI:C0023493
alternative_term: Adult T-cell leukemia/lymphoma
has_obo_namespace: disease_ontology
id: DOID:0050523
in subset: DO cancer slim
in subset: NCIthesaurus

maturity-onset diabetes of the young
type: Class
subclass of: autosomal dominant disease
subclass of: DOID 9351
textual definition: A diabetes mellitus that has_material_basis_in autosomal dominant inheritance of mutations in the MODY genes impacting beta-cell function, typically occurring before 25 years of age and caused by primary insulin secretion defects.
imported from: doid.owl
has cross-reference: GARD:3697
has cross-reference: ICD10CM:E11.8
has cross-reference: KEGG:04950
has cross-reference: OMIM:606391
has cross-reference: ORDO:552
alternative_term: MODY
alternative_term: Mason-type diabetes
has_obo_namespace: disease_ontology
id: DOID:0050524
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

nonphotosensitive trichothiodystrophy 4
type: Class
subclass of: autosomal recessive disease
subclass of: nonphotosensitive trichothiodystrophy
textual definition: A syndrome that is characterized by brittle hair, short stature, decreased fertility and cognitive impairment without photosensitivity has_material_basis_in mutations in the TTDN1 gene.
imported from: doid.owl
has cross-reference: OMIM:234050
alternative_term: AMISH BRITTLE HAIR BRAIN SYNDROME
alternative_term: BIDS syndrome
alternative_term: HAIR-BRAIN SYNDROME
alternative_term: TTD4
has_obo_namespace: disease_ontology
id: DOID:0050528
comment: OMIM mapping confirmed by DO. [SN].

adult spinal muscular atrophy
type: Class
subclass of: autosomal recessive disease
subclass of: spinal muscular atrophy
textual definition: A spinal muscular atrophy that is characterized by progressive muscular weakness and motor disability that typically presents in the third decade of life and has_material_basis_in mutations in the SMN1 or SMN2 genes that are required for the survival of motor neurons.
imported from: doid.owl
has cross-reference: ICD10CM:G12.1
has cross-reference: MESH:C563948
has cross-reference: OMIM:271150
has cross-reference: ORDO:83420
has cross-reference: UMLS_CUI:C1838230
alternative_term: SMA4
alternative_term: SPINAL MUSCULAR ATROPHY, ADULT FORM
alternative_term: SPINAL MUSCULAR ATROPHY, TYPE IV
alternative_term: spinal muscular atrophy 4
has_obo_namespace: disease_ontology
id: DOID:0050529
comment: OMIM mapping confirmed by DO. [SN].

congenital stationary night blindness
type: Class
subclass of: physical disorder
subclass of: hereditary night blindness
textual definition: A hereditary night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves.
imported from: doid.owl
has cross-reference: ICD10CM:H53.63
has cross-reference: ICD9CM:368.61
has cross-reference: MESH:C537743
has cross-reference: OMIM:PS310500
has cross-reference: ORDO:215
has cross-reference: SNOMEDCT_US_2020_03_01:193687000
has cross-reference: UMLS_CUI:C1306122
alternative_term: congenital essential nyctalopia
has_obo_namespace: disease_ontology
id: DOID:0050534
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

exudative vitreoretinopathy
type: Class
subclass of: retinal vascular disease
textual definition: A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina.
imported from: doid.owl
has cross-reference: GARD:1613
has cross-reference: ICD10CM:H35.00
has cross-reference: ICD9CM:362.10
has cross-reference: OMIM:PS133780
has cross-reference: ORDO:891
has cross-reference: SNOMEDCT_US_2020_03_01:193355009
has cross-reference: UMLS_CUI:C0004608
alternative_term: FEVR
alternative_term: familial exudative vitreoretinopathy
has_obo_namespace: disease_ontology
id: DOID:0050535
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

posterior polar cataract
type: Class
subclass of: cataract
textual definition: A cataract that is characterized by a distinctive discoid lens opacity situated posteriorly and adjacent to the posterior capsule.
imported from: doid.owl
alternative_term: CATARACT, POSTERIOR POLAR
has_obo_namespace: disease_ontology
id: DOID:0050537
comment: OMIM mapping confirmed by DO. [SN].

Charcot-Marie-Tooth disease type 1
type: Class
subclass of: Charcot-Marie-Tooth disease
textual definition: A Charcot-Marie-Tooth disease characterized by demyelination of the peripheral nerve axons.
imported from: doid.owl
has cross-reference: GARD:12433
alternative_term: hereditary motor and sensory neuropathy type 1
has_obo_namespace: disease_ontology
id: DOID:0050538
comment: OMIM mapping confirmed by DO. [SN].

Charcot-Marie-Tooth disease type 3
type: Class
subclass of: autosomal dominant disease
subclass of: autosomal recessive disease
subclass of: Charcot-Marie-Tooth disease
textual definition: A Charcot-Marie-Tooth disease that is characterized by motor and sensory peripheral neuropathies caused by demyelination.
imported from: doid.owl
has cross-reference: OMIM:145900
alternative_term: DEJERINE-SOTTAS NEUROPATHY
alternative_term: DEJERINE-SOTTAS SYNDROME
has_obo_namespace: disease_ontology
id: DOID:0050540
comment: OMIM mapping confirmed by DO. [SN].

hypermethioninemia
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050544
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

visceral heterotaxy
type: Class
subclass of: physical disorder
textual definition: A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen.
imported from: doid.owl
has cross-reference: GARD:10875
has cross-reference: OMIM:306955
has cross-reference: OMIM:605376
has cross-reference: OMIM:606325
has cross-reference: OMIM:613751
has cross-reference: OMIM:614779
has cross-reference: ORDO:450
alternative_term: heterotaxia
alternative_term: situs ambiguus
has_obo_namespace: disease_ontology
id: DOID:0050545
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

congenital adrenal insufficiency
type: Class
subclass of: autosomal dominant disease
subclass of: autosomal recessive disease
subclass of: physical disorder
subclass of: DOID 9553
textual definition: An adrenal gland disease that is characterized by cortisol deficiency, hypoaldosteronism and excessive or insufficient sex hormones, has_material_basis_in the mutation in the gene for 21-hydroxylase, 11beta-hydroxylase, 3beta-hydroxysteroid, 17alpha-hydroxylase or 20,22-desmolase.
imported from: doid.owl
has cross-reference: OMIM:613743
alternative_term: ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL, PARTIAL OR COMPLETE
alternative_term: P450scc DEFICIENCY
has_obo_namespace: disease_ontology
id: DOID:0050546
comment: OMIM mapping confirmed by DO. [SN].

familial medullary thyroid carcinoma
type: Class
subclass of: thyroid gland medullary carcinoma
textual definition: A thyroid gland medullary carcinoma that has_material_basis_in autosomal dominant inheritance.
imported from: doid.owl
has cross-reference: OMIM:155240
alternative_term: THYROID CARCINOMA, FAMILIAL MEDULLARY
has_obo_namespace: disease_ontology
id: DOID:0050547
in subset: DO FlyBase slim
comment: OMIM mapping confirmed by DO. [SN].

hereditary sensory neuropathy
type: Class
subclass of: DOID 870
textual definition: A neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages.
imported from: doid.owl
has cross-reference: OMIM:PS162400
alternative_term: familial dysautonomia, type II
alternative_term: hereditary sensory and autonomic neuropathy
has_obo_namespace: disease_ontology
id: DOID:0050548
in subset: DO FlyBase slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

JMP syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy that has_material_basis_in homozygous or compound heterozygous mutation in PSMB8 on chromosome 6p21.32.
imported from: doid.owl
has cross-reference: GARD:10988
has cross-reference: OMIM:256040
has cross-reference: ORDO:324999
alternative_term: JOINT CONTRACTURES, MUSCULAR ATROPHY, MICROCYTIC ANEMIA, AND PANNICULITIS-INDUCED LIPODYSTROPHY
has_obo_namespace: disease_ontology
id: DOID:0050553

X-linked sideroblastic anemia with ataxia
type: Class
subclass of: X-linked recessive disease
subclass of: DOID 8955
textual definition: A sideroblastic anemia that is characterized by decreased production of hemoglobin and ataxia and has_material_basis_in the mutation in the ABCB7 gene.
imported from: doid.owl
has_alternative_id: DOID:0060064
has cross-reference: OMIM:301310
alternative_term: Anemia sideroblastic and spinocerebellar ataxia
alternative_term: X-linked sideroblastic anaemia and ataxia
alternative_term: X-linked sideroblastic anaemia with ataxia
alternative_term: X-linked sideroblastic anemia and ataxia
has_obo_namespace: disease_ontology
id: DOID:0050554
comment: OMIM mapping confirmed by DO. [SN].

congenital muscular dystrophy
type: Class
subclass of: physical disorder
subclass of: DOID 9884
textual definition: A muscular dystrophy that is characterized by diminished muscle tone (hypotonia), progressive muscle weakness and degeneration (atrophy), abnormally fixed joints, spinal rigidity, and delays in reaching motor milestones such as sitting or standing unassisted.
imported from: doid.owl
has cross-reference: GARD:9138
has cross-reference: ICD9CM:359.0
has cross-reference: OMIM:254100
has cross-reference: ORDO:97242
has cross-reference: SNOMEDCT_US_2020_03_01:193221009
has cross-reference: UMLS_CUI:C2937300
has_obo_namespace: disease_ontology
id: DOID:0050557
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Ullrich congenital muscular dystrophy
type: Class
subclass of: congenital muscular dystrophy
subclass of: autosomal dominant disease
subclass of: autosomal recessive disease
textual definition: A congenital muscular dystrophy that is characterized by muscle weakness and respiratory depression and has_material_basis_in mutation in the COL6A1, COL6A2 and COL6A3 that produce components of type VI collagen.
imported from: doid.owl
has cross-reference: GARD:4769
has cross-reference: OMIM:254090
alternative_term: ULLRICH DISEASE
alternative_term: Ullrich scleroatonic muscular dystrophy
has_obo_namespace: disease_ontology
id: DOID:0050558
comment: OMIM mapping confirmed by DO. [SN].

Fukuyama congenital muscular dystrophy
type: Class
subclass of: congenital muscular dystrophy-dystroglycanopathy type A
textual definition: A congenital muscular dystrophy-dystroglycanopathy type A that is characterized by muscle weakness, failure to thrive, severe intellectual and developmental disability, impaired vision and cardiac abnormalities and has_material_basis_in mutation in the FKTN gene that produces the fukutin protein.
imported from: doid.owl
has cross-reference: GARD:6475
has cross-reference: OMIM:253800
has cross-reference: ORDO:272
has_obo_namespace: disease_ontology
id: DOID:0050559
comment: OMIM mapping confirmed by DO. [SN].

Walker-Warburg syndrome
type: Class
subclass of: congenital muscular dystrophy
subclass of: autosomal recessive disease
textual definition: A congenital muscular dystrophy that is characterized by hypotonia, seizures, severe intellectual and developmental disability, eye abnormalities and early death and has_material_basis_in mutations in multiple genes including POMT1, POMT2, ISPD, FKTN, FKRP, and LARGE1.
imported from: doid.owl
has cross-reference: GARD:2599
has cross-reference: MESH:D058494
alternative_term: HARD syndrome
alternative_term: cerebroocular dysplasia-muscular dystrophy syndrome
has_obo_namespace: disease_ontology
id: DOID:0050560
in subset: DO FlyBase slim
comment: OMIM mapping confirmed by DO. [SN].

Lennox-Gastaut syndrome
type: Class
subclass of: childhood electroclinical syndrome
textual definition: A childhood electroclinical syndrome that is characterized by frequent seizures and intellectual disability that present in early childhood.
imported from: doid.owl
has cross-reference: GARD:9912
has cross-reference: OMIM:606369
has cross-reference: ORDO:2382
alternative_term: Lennox syndrome
has_obo_namespace: disease_ontology
id: DOID:0050561

nonsyndromic deafness
type: Class
subclass of: auditory system disease
textual definition: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.
imported from: doid.owl
alternative_term: nonsyndromic hearing loss
alternative_term: nonsyndromic hereditary hearing loss
has_obo_namespace: disease_ontology
id: DOID:0050563

X-linked nonsyndromic deafness
type: Class
subclass of: nonsyndromic deafness
subclass of: X-linked monogenic disease
textual definition: A nonsyndromic deafness characterized by an X-linked inheritance mode.
imported from: doid.owl
has cross-reference: ICD10CM:H90.3
has cross-reference: OMIM:PS304500
has cross-reference: ORDO:90625
alternative_term: X-linked deafness
has_obo_namespace: disease_ontology
id: DOID:0050566
in subset: DO rare slim
comment: OMIM mapping confirmed by DO. [SN].

orofacial cleft
type: Class
subclass of: physical disorder
subclass of: syndrome
textual definition: A physical disorder that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development.
imported from: doid.owl
has cross-reference: OMIM:PS119530
has_obo_namespace: disease_ontology
id: DOID:0050567
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

spondylocostal dysostosis
type: Class
subclass of: spinal disease
subclass of: dysostosis
textual definition: A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together.
imported from: doid.owl
has cross-reference: GARD:12174
has cross-reference: GARD:6798
has cross-reference: OMIM:122600
has cross-reference: OMIM:277300
has cross-reference: OMIM:608681
has cross-reference: OMIM:609813
has cross-reference: OMIM:613686
has cross-reference: ORDO:1797
has cross-reference: ORDO:2311
alternative_term: Jarcho-Levin syndrome
alternative_term: spondylocostal dysostosis, autosomal recessive 3
alternative_term: spondylothoracic dysostosis
alternative_term: spondylothoracic dysplasia
has_obo_namespace: disease_ontology
id: DOID:0050568
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Seckel syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability.
imported from: doid.owl
has cross-reference: GARD:8562
has cross-reference: ICD10CM:Q87.1
has cross-reference: OMIM:PS210600
has cross-reference: ORDO:808
alternative_term: Harper's syndrome
alternative_term: Virchow-Seckel dwarfism
alternative_term: bird-headed dwarfism
alternative_term: microcephalic primordial dwarfism
has_obo_namespace: disease_ontology
id: DOID:0050569
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

cone-rod dystrophy
type: Class
subclass of: monogenic disease
subclass of: retinal degeneration
textual definition: A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells.
imported from: doid.owl
has cross-reference: GARD:10790
has cross-reference: ICD10CM:H35.5
has cross-reference: ORDO:1872
alternative_term: cone-rod retinal dystrophy
has_obo_namespace: disease_ontology
id: DOID:0050572
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

2-hydroxyglutaric aciduria
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage.
imported from: doid.owl
has cross-reference: GARD:10761
has_obo_namespace: disease_ontology
id: DOID:0050573

L-2-hydroxyglutaric aciduria
type: Class
subclass of: 2-hydroxyglutaric aciduria
subclass of: cerebellar disease
textual definition: An 2-hydroxyglutaric aciduria that involves damage to cerebellum affecting movement coordination resulting in problems with balance and muscle coordination (ataxia).
imported from: doid.owl
has cross-reference: GARD:10472
has cross-reference: OMIM:236792
has cross-reference: ORDO:79314
alternative_term: L-2-HYDROXYGLUTARIC ACIDEMIA
has_obo_namespace: disease_ontology
id: DOID:0050574

D-2-hydroxyglutaric aciduria
type: Class
subclass of: 2-hydroxyglutaric aciduria
textual definition: An 2-hydroxyglutaric aciduria that involves developmental delay, seizures, weak muscle tone (hypotonia), and abnormalities in the largest part of the brain (the cerebrum), which controls many important functions such as muscle movement, speech, vision, thinking, emotion, and memory.
imported from: doid.owl
has cross-reference: GARD:5661
has cross-reference: OMIM:PS600721
has_obo_namespace: disease_ontology
id: DOID:0050575
in subset: DO FlyBase slim

cranioectodermal dysplasia
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by characterized by sagittal craniosynostosis and facial, ectodermal, and skeletal anomalies.
imported from: doid.owl
has cross-reference: OMIM:PS218330
alternative_term: Levin syndrome
alternative_term: Sensenbrenner syndrome
has_obo_namespace: disease_ontology
id: DOID:0050577
comment: OMIM mapping confirmed by DO. [SN].

occult macular dystrophy
type: Class
subclass of: macular degeneration
textual definition: A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.
imported from: doid.owl
has cross-reference: OMIM:613587
has_obo_namespace: disease_ontology
id: DOID:0050578
comment: OMIM mapping confirmed by DO. [SN].

brachydactyly
type: Class
subclass of: dysostosis
textual definition: A dysostosis characterized by short fingers and toes.
imported from: doid.owl
has cross-reference: GARD:11913
has cross-reference: ORDO:294937
has_obo_namespace: disease_ontology
id: DOID:0050581
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

trichotillomania
type: Class
subclass of: impulse control disorder
textual definition: An impulse control disorder that involves the uncontrollable plucking of ones hair.
imported from: doid.owl
has cross-reference: GARD:7803
has cross-reference: MESH:D014256
has cross-reference: OMIM:613229
has_obo_namespace: disease_ontology
id: DOID:0050587
comment: OMIM mapping confirmed by DO. [SN].

muscular dystrophy-dystroglycanopathy
type: Class
subclass of: congenital muscular dystrophy
subclass of: autosomal recessive disease
textual definition: A congenital muscular dystrophy characterized by muscle weakness, cognitive impairment and brain abnormalities and has_material_basis_in mutation to the POMT1 gene that encodes O-mannosyltransferase.
imported from: doid.owl
has cross-reference: ICD10CM:G71.2
has cross-reference: OMIM:613151
has cross-reference: OMIM:613152
has cross-reference: OMIM:613155
has cross-reference: OMIM:613156
has cross-reference: OMIM:615351
has cross-reference: OMIM:616094
has cross-reference: OMIM:PS613155
has cross-reference: ORDO:370953
alternative_term: CMD due to dystroglycanopathy
has_obo_namespace: disease_ontology
id: DOID:0050588
in subset: DO rare slim
comment: Xref MGI.

inflammatory bowel disease
type: Class
subclass of: intestinal disease
textual definition: An intestinal disease characterized by inflammation located in all parts of digestive tract.
imported from: doid.owl
has cross-reference: EFO:0003767
has cross-reference: KEGG:05321
has cross-reference: MESH:D015212
has cross-reference: NCI:C3138
has cross-reference: OMIM:PS266600
has cross-reference: SNOMEDCT_US_2020_03_01:155759008
has cross-reference: UMLS_CUI:C0021390
has_obo_namespace: disease_ontology
id: DOID:0050589
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

severe congenital neutropenia
type: Class
subclass of: physical disorder
subclass of: neutropenia
textual definition: A neutropenia characterized by a maturation arrest of granulopoiesis at the level or promyelocytes and early onset of severe bacterial infections.
imported from: doid.owl
has cross-reference: GARD:13592
has cross-reference: ICD10CM:D70
has cross-reference: OMIM:PS202700
has cross-reference: ORDO:42738
has_obo_namespace: disease_ontology
id: DOID:0050590
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

tooth agenesis
type: Class
subclass of: tooth disease
textual definition: A tooth disease characterized by failure to develop on or more missing teeth.
imported from: doid.owl
has cross-reference: ICD10CM:K00.0
has cross-reference: ICD9CM:520.0
has cross-reference: MESH:D000848
has cross-reference: OMIM:106600
has cross-reference: OMIM:150400
has cross-reference: OMIM:313500
has cross-reference: OMIM:602639
has cross-reference: OMIM:604625
has cross-reference: OMIM:610926
has cross-reference: ORDO:2227
has cross-reference: ORDO:99798
has cross-reference: SNOMEDCT_US_2020_03_01:234951001
has cross-reference: UMLS_CUI:C0399352
alternative_term: familial tooth agenesis
alternative_term: hypodontia
alternative_term: oligodontia
alternative_term: selective tooth agenesis
has_obo_namespace: disease_ontology
id: DOID:0050591
in subset: DO rare slim
comment: Xref MGI.

asphyxiating thoracic dystrophy
type: Class
subclass of: bone development disease
textual definition: A bone development disease characterized by skeletal abnormalities and resulting in difficulty in breathing caused by mutations that result in ciliopathy.
imported from: doid.owl
has cross-reference: ICD10CM:Q77.2
has cross-reference: OMIM:PS208500
has cross-reference: ORDO:474
alternative_term: Jeune syndrome
alternative_term: short-rib thoracic dysplasia with or without polydactyly
alternative_term: thoracic pelvic phalangeal dystrophy
has_obo_namespace: disease_ontology
id: DOID:0050592
comment: OMIM mapping confirmed by DO. [SN].

taeniasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that has_material_basis_in Taenia solium or has_material_basis_in Taenia saginata, which are transmitted by ingestion of undercooked contaminated meat.
imported from: doid.owl
has_alternative_id: DOID:10076
has cross-reference: ICD10CM:B68.1
has cross-reference: ICD9CM:123.2
has cross-reference: SNOMEDCT_US_2020_03_01:69163003
has cross-reference: UMLS_CUI:C0152073
has_obo_namespace: disease_ontology
has_related_synonym: Beef tapeworm infection
has_related_synonym: Infection by Taeniarhynchus saginatus
has_related_synonym: Taenia saginata infectious disease
id: DOID:0050596

intestinal schistosomiasis
type: Class
subclass of: schistosomiasis
subclass of: intestinal disease
textual definition: A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.
imported from: doid.owl
has_alternative_id: DOID:13692
has_alternative_id: DOID:13721
has_alternative_id: DOID:3468
has cross-reference: ICD10CM:B65.1
has cross-reference: ICD10CM:B65.2
has cross-reference: ICD9CM:120.1
has cross-reference: ICD9CM:120.2
has cross-reference: MESH:D012554
has cross-reference: MESH:D012555
has cross-reference: NCI:C35001
has cross-reference: NCI:C35002
has cross-reference: NCI:C35364
has cross-reference: OMIM:181460
has cross-reference: ORDO:1247
has cross-reference: SNOMEDCT_US_2020_03_01:187114003
has cross-reference: SNOMEDCT_US_2020_03_01:52179003
has cross-reference: SNOMEDCT_US_2020_03_01:750009
has cross-reference: UMLS_CUI:C0036329
has cross-reference: UMLS_CUI:C0036330
has cross-reference: UMLS_CUI:C0276932
alternative_term: Katayama fever
alternative_term: Schistosoma japonicum infection
alternative_term: Schistosoma mansoni infectious disease
alternative_term: schistosomiasis japonica
has_obo_namespace: disease_ontology
id: DOID:0050597
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

extrapulmonary tuberculosis
type: Class
subclass of: tuberculosis
textual definition: A tuberculosis that occurs at body sites other than the lung.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050598

abdominal tuberculosis
type: Class
subclass of: extrapulmonary tuberculosis
textual definition: An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050599

ABCD syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB).
imported from: doid.owl
has cross-reference: OMIM:600501
alternative_term: ABCDS
alternative_term: albinism, black lock, cell migration disorder of the neurocytes of the gut, and deafness
has_obo_namespace: disease_ontology
id: DOID:0050600
comment: OMIM mapping confirmed by DO. [SN].

ADULT syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63.
imported from: doid.owl
has cross-reference: GARD:384
has cross-reference: OMIM:103285
alternative_term: acro-dermato-ungual-lacrimal-tooth syndrome
has_obo_namespace: disease_ontology
id: DOID:0050601
comment: OMIM mapping confirmed by DO. [SN].

triple-A syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by achalasia, adrenal insufficiency and alacrima and has_material_basis_in mutations in the AAAS gene that encodes ALADIN within the nuclear envelope and results in dysfunction of the autonomic nervous system.
imported from: doid.owl
has cross-reference: GARD:457
has cross-reference: OMIM:231550
alternative_term: AAAS
alternative_term: Achalasia-Addisonianism-Alacrimia syndrome
alternative_term: Allgrove Syndrome
has_obo_namespace: disease_ontology
id: DOID:0050602
comment: OMIM mapping confirmed by DO. [SN].

acheiropody
type: Class
subclass of: autosomal recessive disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia characterized by a lack of formation of the distal extremities has_material_basis_in mutation in the LMBR1 gene.
imported from: doid.owl
has cross-reference: GARD:376
has cross-reference: OMIM:200500
alternative_term: Acheiropodia
alternative_term: Horn-Kolb Syndrome
has_obo_namespace: disease_ontology
id: DOID:0050603
comment: OMIM mapping confirmed by DO. [SN].

acrodermatitis enteropathica
type: Class
subclass of: genetic disease
subclass of: DOID 896
textual definition: A metal metabolism disorder characterized by dermatitis around bodily openings and the tips of fingers and toes, alopecia and diarrhea and has_material_basis_in mutation in the SLC39A4 gene that encodes a zinc uptake protein and results in zinc deficiency.
imported from: doid.owl
has cross-reference: GARD:5723
has cross-reference: OMIM:201100
has_obo_namespace: disease_ontology
id: DOID:0050605

acrokeratosis verruciformis
type: Class
subclass of: autosomal dominant disease
subclass of: keratosis
textual definition: A keratosis that has_material_basis_in mutations in the ATP2A2 gene.
imported from: doid.owl
has cross-reference: OMIM:101900
alternative_term: Acrokeratosis verruciformis of Hopf
alternative_term: Hopf disease
has_obo_namespace: disease_ontology
id: DOID:0050606
comment: OMIM mapping confirmed by DO. [SN].

respiratory system cancer
type: Class
subclass of: organ system cancer
subclass of: respiratory system disease
textual definition: An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050615

paranasal sinus cancer
type: Class
subclass of: respiratory system cancer
subclass of: paranasal sinus disease
textual definition: A respiratory system cancer that is located_in the paranasal sinuses.
imported from: doid.owl
has_alternative_id: DOID:1354
has_alternative_id: DOID:2442
has_alternative_id: DOID:2765
has_alternative_id: DOID:2767
has_alternative_id: DOID:4689
has cross-reference: MESH:D010255
has cross-reference: NCI:C6014
has cross-reference: NCI:C6017
has cross-reference: NCI:C6018
has cross-reference: NCI:C6019
has cross-reference: NCI:C8193
has cross-reference: UMLS_CUI:C0280334
has cross-reference: UMLS_CUI:C0854995
has cross-reference: UMLS_CUI:C1335336
has cross-reference: UMLS_CUI:C1335337
has cross-reference: UMLS_CUI:C1335340
alternative_term: Epidermoid carcinoma of the paranasal sinus
alternative_term: Mucoepidermoid carcinoma of Accessory sinus
alternative_term: adenoid cystic carcinoma of Accessory sinus
alternative_term: paranasal sinus adenocarcinoma
alternative_term: paranasal sinus adenoid cystic carcinoma
alternative_term: paranasal sinus mucoepidermoid carcinoma
alternative_term: paranasal sinus squamous cell carcinoma
has_obo_namespace: disease_ontology
has_related_synonym: adenoid cystic carcinoma of paranasal sinus
has_related_synonym: squamous cell carcinoma of paranasal sinus
id: DOID:0050619
in subset: NCIthesaurus

respiratory system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: respiratory system disease
textual definition: An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050621

reproductive organ benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: reproductive system disease
textual definition: An organ system benign neoplasm that is located_in reproductive system organs.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050622

bladder benign neoplasm
type: Class
subclass of: bladder disease
subclass of: urinary system benign neoplasm
textual definition: A urinary system benign neoplasm located_in the bladder including papillomas, leiomyomas, fibromas, hemangiomas, neurofibromas and lipomas.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050623

gastrointestinal system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: gastrointestinal system disease
textual definition: An organ system benign neoplasm located_in gastrointestinal tract organs.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050624

biliary tract benign neoplasm
type: Class
subclass of: hepatobiliary benign neoplasm
subclass of: DOID 9741
textual definition: A hepatobiliary benign neoplasm located_in the biliary tract.
imported from: doid.owl
has_alternative_id: DOID:4609
has cross-reference: NCI:C4441
has cross-reference: SNOMEDCT_US_2020_03_01:126855001
has cross-reference: UMLS_CUI:C0345913
alternative_term: extrahepatic bile duct neoplasm
alternative_term: neoplasm of extrahepatic bile ducts
alternative_term: tumor of the extrahepatic bile duct
has_obo_namespace: disease_ontology
id: DOID:0050625
in subset: NCIthesaurus

Aicardi-Goutieres syndrome
type: Class
subclass of: autosomal genetic disease
subclass of: syndrome
textual definition: A syndrome that is a genetically heterogeneous encephalopathy characterized in its most severe form by cerebral atrophy, leukodystrophy, intracranial calcifications, chronic cerebrospinal fluid lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infections.
imported from: doid.owl
has cross-reference: GARD:575
has cross-reference: ICD10CM:G31.8
has cross-reference: OMIM:225750
has cross-reference: OMIM:610181
has cross-reference: OMIM:610329
has cross-reference: OMIM:610333
has cross-reference: OMIM:612952
has cross-reference: OMIM:615010
has cross-reference: OMIM:615846
has cross-reference: ORDO:51
alternative_term: Cree encephalitis
has_obo_namespace: disease_ontology
id: DOID:0050629
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Aland Island eye disease
type: Class
subclass of: X-linked recessive disease
subclass of: eye disease
textual definition: An eye disease characterized by fundus hypopigmentation, decreased visual acuity, nystagmus, astigmatism, myopia and defective darkness adaptation and has_material_basis_in mutation in the CACNA1F gene.
imported from: doid.owl
has cross-reference: GARD:10574
has cross-reference: MESH:C562664
has cross-reference: OMIM:300600
alternative_term: FORSIUS-ERIKSSON TYPE OCULAR ALBINISM
alternative_term: Forsius-Eriksson syndrome
has_obo_namespace: disease_ontology
id: DOID:0050630

Allan-Herndon-Dudley syndrome
type: Class
subclass of: X-linked recessive disease
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in mutation at is in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.
imported from: doid.owl
has cross-reference: GARD:5617
has cross-reference: MESH:C537047
has cross-reference: OMIM:300523
has cross-reference: ORDO:59
alternative_term: AHDS
alternative_term: ALLAN-HERNDON SYNDROME
has_obo_namespace: disease_ontology
id: DOID:0050631
comment: OMIM mapping confirmed by DO. [SN].

oculocutaneous albinism
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by abnormal pigmentation of the skin, hair and eyes.
imported from: doid.owl
has cross-reference: GARD:10958
has cross-reference: ICD10CM:E70.3
has cross-reference: MESH:D016115
has cross-reference: OMIM:PS203100
has cross-reference: ORDO:55
has_obo_namespace: disease_ontology
id: DOID:0050632
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

ocular albinism
type: Class
subclass of: eye disease
textual definition: An eye disease that is characterized by reduced pigmentation of the iris and the resulting impairment of visual acuity without significantly affecting the color of skin or hair and has_material_basis in mutation in the GPR143 gene that encodes segments of the melanosomes that stores melanin.
imported from: doid.owl
has cross-reference: MESH:D016117
has cross-reference: OMIM:300500
has_obo_namespace: disease_ontology
id: DOID:0050633

primary cutaneous amyloidosis
type: Class
subclass of: skin disease
subclass of: DOID 9120
textual definition: An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis.
imported from: doid.owl
has cross-reference: GARD:132
has cross-reference: OMIM:105250
has cross-reference: OMIM:613955
has cross-reference: ORDO:137807
alternative_term: PCA
alternative_term: familial primary localized cutaneous amyloidosis
has_obo_namespace: disease_ontology
id: DOID:0050639
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

arterial calcification of infancy
type: Class
subclass of: artery disease
textual definition: A vascular disease that is characterized by generalized calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall.
imported from: doid.owl
has cross-reference: GARD:8380
has cross-reference: MESH:C537440
has cross-reference: OMIM:208000
has cross-reference: OMIM:614473
has cross-reference: ORDO:51608
alternative_term: generalized arterial calcification of infancy
alternative_term: idiopathic infantile arterial calcification
alternative_term: infantile arteriosclerosis
has_obo_namespace: disease_ontology
id: DOID:0050644
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

arterial tortuosity syndrome
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta.
imported from: doid.owl
has cross-reference: GARD:774
has cross-reference: MESH:C565942
has cross-reference: OMIM:208050
has_obo_namespace: disease_ontology
id: DOID:0050645
comment: OMIM mapping confirmed by DO. [SN].

distal arthrogryposis
type: Class
subclass of: muscle tissue disease
textual definition: A muscle tissue disease characterized by congenital joint contractures of hand and feet.
imported from: doid.owl
has cross-reference: GARD:786
has cross-reference: OMIM:108120
has cross-reference: OMIM:108145
has cross-reference: OMIM:108200
has cross-reference: OMIM:114300
has cross-reference: OMIM:121050
has cross-reference: OMIM:121070
has cross-reference: OMIM:158300
has cross-reference: OMIM:187370
has cross-reference: OMIM:193700
has cross-reference: OMIM:601680
has cross-reference: OMIM:609128
has cross-reference: OMIM:614335
has cross-reference: OMIM:615065
has cross-reference: ORDO:1147
has cross-reference: ORDO:97120
alternative_term: Arthrogryposis Multiplex Congenita
alternative_term: Freeman-Sheldon syndrome
has_obo_namespace: disease_ontology
id: DOID:0050646
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Arts syndrome
type: Class
subclass of: syndromic X-linked intellectual disability
textual definition: An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene.
imported from: doid.owl
has cross-reference: GARD:8756
has cross-reference: MESH:C535388
has cross-reference: OMIM:301835
has cross-reference: ORDO:1187
has cross-reference: SNOMEDCT_US_2020_03_01:702441001
has cross-reference: UMLS_CUI:C0796028
alternative_term: ARTS
alternative_term: Lethal ataxia with deafness and optic atrophy
alternative_term: MRXS18
alternative_term: MRXSARTS
alternative_term: fatal X-linked ataxia with deafness and loss of vision
alternative_term: syndromic X-linked mental retardation 18
alternative_term: syndromic X-linked mental retardation Arts type
has_obo_namespace: disease_ontology
id: DOID:0050647
comment: OMIM mapping confirmed by DO. [SN].

atelosteogenesis
type: Class
subclass of: spinal disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that is characterized by specific patterns of aplasia/hypoplasia of humeri, femora, spine in newborns.
imported from: doid.owl
has cross-reference: OMIM:108720
has cross-reference: OMIM:108721
has cross-reference: OMIM:256050
has_obo_namespace: disease_ontology
id: DOID:0050648
comment: OMIM mapping confirmed by DO. [SN].

atransferrinemia
type: Class
subclass of: autosomal recessive disease
subclass of: DOID 896
textual definition: A metal metabolism disorder that is characterized by transferrin deficiency, microcytic anemia, and iron loading, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the structural gene for transferrin on chromosome 3q22.
imported from: doid.owl
has cross-reference: GARD:9595
has cross-reference: NCI:C125693
has cross-reference: OMIM:209300
has cross-reference: ORDO:1195
alternative_term: familial hypotransferrinemia
has_obo_namespace: disease_ontology
id: DOID:0050649
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

familial atrial fibrillation
type: Class
subclass of: atrial fibrillation
textual definition: An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes.
imported from: doid.owl
has cross-reference: GARD:9740
has cross-reference: OMIM:607554
has cross-reference: OMIM:608583
has cross-reference: OMIM:608988
has cross-reference: OMIM:611493
has cross-reference: OMIM:611494
has cross-reference: OMIM:612201
has cross-reference: OMIM:612240
has cross-reference: OMIM:613055
has cross-reference: OMIM:613980
has cross-reference: OMIM:614022
has cross-reference: OMIM:614049
has cross-reference: OMIM:614050
has cross-reference: OMIM:615377
has cross-reference: OMIM:615378
has cross-reference: OMIM:615770
has cross-reference: OMIM:PS608583
has cross-reference: ORDO:334
alternative_term: ATFB
has_obo_namespace: disease_ontology
id: DOID:0050650
in subset: DO rare slim
comment: Xref MGI.

atrioventricular septal defect
type: Class
subclass of: heart septal defect
textual definition: A congenital heart septal defect characterized by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the atrial septum and the muscular portion of the ventricular septum, thus allowing extra blood to circulate the lungs.
imported from: doid.owl
has cross-reference: GARD:802
has cross-reference: ICD10CM:Q21.2
has cross-reference: ICD9CM:745.6
has cross-reference: MESH:D004694
has cross-reference: OMIM:600309
has cross-reference: OMIM:606215
has cross-reference: OMIM:614430
has cross-reference: OMIM:614474
has cross-reference: ORDO:98722
has cross-reference: SNOMEDCT_US_2020_03_01:204322008
has cross-reference: UMLS_CUI:C0014116
alternative_term: AVCD
alternative_term: AVSD
alternative_term: ECD
alternative_term: atrioventricular canal defect
alternative_term: endocardial cushion defect
has_obo_namespace: disease_ontology
id: DOID:0050651
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Baller-Gerold syndrome
type: Class
subclass of: synostosis
textual definition: A synostosis characterized by coronal craniosynostosis, short stature, and aplasia or hypoplasia of the radial bone.
imported from: doid.owl
has cross-reference: GARD:1602
has cross-reference: MESH:C536788
has cross-reference: OMIM:218600
has cross-reference: ORDO:1223
has cross-reference: SNOMEDCT_US_2020_03_01:77608001
has cross-reference: UMLS_CUI:C0265308
has_obo_namespace: disease_ontology
id: DOID:0050654
in subset: DO rare slim
comment: OMIM mapping confirmed by DO. [SN].

Bamforth-Lazarus syndrome
type: Class
subclass of: hypothyroidism
textual definition: A hypothyroidism that is characterized by thyroid dysgenesis, cleft palate, spiky hair and bifid epiglottis, has_material_basis_in homozygous mutation in the FKHL15 gene on chromosome 9q22.
imported from: doid.owl
has cross-reference: OMIM:241850
alternative_term: HYPOTHYROIDISM, ATHYROIDAL, WITH SPIKY HAIR AND CLEFT PALATE
has_obo_namespace: disease_ontology
id: DOID:0050655
comment: OMIM mapping confirmed by DO. [SN].

pseudo-TORCH syndrome 1
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by congenital microcephaly, intracranial calcifications, severe developmental delay, simplified gyration and polymicrogyria that has_material_basis_in homozygous or compound heterozygous mutation in OCLN on chromosome 5q13.2.
imported from: doid.owl
has cross-reference: GARD:12426
has cross-reference: OMIM:251290
has cross-reference: ORDO:1229
alternative_term: BLC-PMG
alternative_term: BLCPMG
alternative_term: Baraitser-Brett-Piesowicz syndrome
alternative_term: Baraitser-Reardon syndrome
alternative_term: PTORCH1
alternative_term: band-like calcification with simplified gyration and polymicrogyria
alternative_term: bilateral band-like calcification with polymicrogyria
alternative_term: microcephaly-intracranial calcification-intellectual disability syndrome
has_obo_namespace: disease_ontology
id: DOID:0050656

Bannayan-Riley-Ruvalcaba syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: penile disease
subclass of: syndrome
textual definition: A syndrome that is characterized by macrocephaly, multiple noncancerous tumors and hamartomas, and dark freckles on the penis, and has_material_basis_in heterozygous germline mutation in the PTEN gene on chromosome 10q23.
imported from: doid.owl
has cross-reference: GARD:5887
has cross-reference: ICD10CM:Q87.89
has cross-reference: MESH:D006223
has cross-reference: NCI:C3939
has cross-reference: OMIM:158350
has cross-reference: ORDO:109
alternative_term: Bannayan-Zonana syndrome
alternative_term: Riley-Smith syndrome
alternative_term: Ruvalcaba-Myhre-Smith syndrome
has_obo_namespace: disease_ontology
id: DOID:0050657
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Bart-Pumphrey syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by leukonychia, wart-like skin growths, palmoplantar keratoderma and hearing loss, has_material_basis_in heterozygous mutation in the GJB2 gene on chromosome 13q12.
imported from: doid.owl
has cross-reference: OMIM:149200
alternative_term: KNUCKLE PADS, LEUKONYCHIA, AND SENSORINEURAL DEAFNESS
has_obo_namespace: disease_ontology
id: DOID:0050658
comment: OMIM mapping confirmed by DO. [SN].

biotin-responsive basal ganglia disease
type: Class
subclass of: basal ganglia disease
textual definition: A basal ganglia disease that is characterized by recurrent subacute encephalopathy, has_symptom confusion, has_symptom seizure, has_symptom ataxia, has_symptom dystonia, has_symptom supranuclear facial palsy, has_symptom external ophthalmoplegia, and has_symptom dysphagia.
imported from: doid.owl
has cross-reference: MESH:C537658
has cross-reference: OMIM:607483
has_obo_namespace: disease_ontology
id: DOID:0050659
comment: OMIM mapping confirmed by DO. [SN].

Beare-Stevenson cutis gyrata syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by cutis gyrata, acanthosis nigricans and craniosynostosis, has_material_basis_in heterozygous mutation in the FGFR2 gene on chromosome 10q26.
imported from: doid.owl
has cross-reference: GARD:332
has cross-reference: OMIM:123790
has_obo_namespace: disease_ontology
id: DOID:0050660
comment: OMIM mapping confirmed by DO. [SN].

vitelliform macular dystrophy
type: Class
subclass of: macular degeneration
textual definition: A macular degeneration that it is characterized by the disruption of cells in a small area near the center of the retina, the macula and may cause progressive vision loss.
imported from: doid.owl
has cross-reference: GARD:10120
has cross-reference: GARD:182
has cross-reference: ICD10CM:H35.5
has cross-reference: MESH:D057826
has cross-reference: OMIM:153700
has cross-reference: OMIM:153840
has cross-reference: OMIM:608161
has cross-reference: OMIM:616151
has cross-reference: OMIM:616152
has cross-reference: ORDO:1243
has cross-reference: ORDO:99000
alternative_term: Best disease
alternative_term: Best macular dystrophy
alternative_term: juvenile-onset vitelliform macular dystrophy
has_obo_namespace: disease_ontology
id: DOID:0050661
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

bestrophinopathy
type: Class
subclass of: macular degeneration
textual definition: A macular degeneration that is characterized by central vision loss, an absent electrooculogram light rise and a reduced electroretinogram, has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the BEST1 gene on chromosome 11q12.
imported from: doid.owl
has cross-reference: MESH:C567518
has cross-reference: OMIM:611809
alternative_term: autosomal recessive bestrophinopathy
has_obo_namespace: disease_ontology
id: DOID:0050662
comment: OMIM mapping confirmed by DO. [SN].

Bethlem myopathy
type: Class
subclass of: congenital muscular dystrophy
textual definition: A congenital muscular dystrophy that is characterized by myopathy and joint contractures that progresses slowly, has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the COL6A1 gene, the COL6A2 gene, or the COL6A3 gene.
imported from: doid.owl
has cross-reference: GARD:873
has cross-reference: OMIM:158810
alternative_term: benign congenital muscular dystrophy
has_obo_namespace: disease_ontology
id: DOID:0050663
comment: OMIM mapping confirmed by DO. [SN].

fetal alcohol syndrome
type: Class
subclass of: fetal alcohol spectrum disorder
textual definition: A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050665

partial fetal alcohol syndrome
type: Class
subclass of: fetal alcohol spectrum disorder
textual definition: A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050666

alcohol-related neurodevelopmental disorder
type: Class
subclass of: fetal alcohol spectrum disorder
textual definition: A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.
imported from: doid.owl
alternative_term: ARND
alternative_term: static encephalopathy
has_obo_namespace: disease_ontology
id: DOID:0050667

spastic cerebral palsy
type: Class
subclass of: cerebral palsy
textual definition: A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050669

ataxic cerebral palsy
type: Class
subclass of: cerebral palsy
textual definition: A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.
imported from: doid.owl
has cross-reference: GARD:10451
has cross-reference: OMIM:605388
alternative_term: hypotonic cerebral palsy
has_obo_namespace: disease_ontology
id: DOID:0050670

congenital bile acid synthesis defect
type: Class
subclass of: physical disorder
subclass of: steroid inherited metabolic disorder
textual definition: A steroid inherited metabolic disorder characterized by abnormal conversion of cholesterol into bile acids which occurs predominantly in the liver.
imported from: doid.owl
has cross-reference: ICD10CM:K76.8
alternative_term: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency
alternative_term: CBA
alternative_term: cholestasis with delta(4)-3-oxosteroid-5-beta-reductase deficiency
has_obo_namespace: disease_ontology
id: DOID:0050674
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Birk-Barel syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by intellectual disability, hypotonia, hyperactivity and facies, has_material_basis_in heterozygous mutation in the KCNK9 gene on chromosome 8q24.
imported from: doid.owl
has cross-reference: GARD:10358
has cross-reference: MESH:C567357
has cross-reference: OMIM:612292
alternative_term: Birk-Barel mental retardation dysmorphism syndrome
has_obo_namespace: disease_ontology
id: DOID:0050675
comment: OMIM mapping confirmed by DO. [SN].

Birt-Hogg-Dube syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: skin disease
textual definition: A skin disease that is characterized by the development of skin papules on the head, face and upper torso, has_material_basis_in heterozygous mutation in the gene encoding folliculin on chromosome 17p11.
imported from: doid.owl
has cross-reference: GARD:2322
has cross-reference: MESH:D058249
has cross-reference: OMIM:135150
has_obo_namespace: disease_ontology
id: DOID:0050676
in subset: DO FlyBase slim
comment: OMIM mapping confirmed by DO. [SN].

Blau syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome characterized by familial granulomatous arthritis, uveitis and skin granulomas. It has_material_basis_in heterozygous mutations in the NOD2 gene.
imported from: doid.owl
has cross-reference: GARD:304
has cross-reference: NCI:C116794
has cross-reference: OMIM:186580
alternative_term: ARTHROCUTANEOUVEAL GRANULOMATOSIS
alternative_term: BLAUS
alternative_term: Jabs syndrome
has_obo_namespace: disease_ontology
id: DOID:0050678
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

blue cone monochromacy
type: Class
subclass of: X-linked recessive disease
subclass of: achromatopsia
textual definition: An achromatopsia that is characterized by severely impaired color discrimination, low visual acuity, nystagmus, photophobia due to the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina and has_material_basis_in recessive X-linked inheritance.
imported from: doid.owl
has cross-reference: GARD:917
has cross-reference: OMIM:303700
has_obo_namespace: disease_ontology
id: DOID:0050679
comment: OMIM mapping confirmed by DO. [SN].

Boomerang dysplasia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that is characterized by severe dwarfism, dislocated joints, club feet, distinctive facies and dysplastic tubular bones with boomerang-like bowing, has_material_basis_in heterozygous mutation in the FLNB gene on chromosome 3p14.
imported from: doid.owl
has cross-reference: GARD:933
has cross-reference: OMIM:112310
has_obo_namespace: disease_ontology
id: DOID:0050680
comment: OMIM mapping confirmed by DO. [SN].

Borjeson-Forssman-Lehmann syndrome
type: Class
subclass of: syndromic X-linked intellectual disability
subclass of: X-linked recessive disease
textual definition: An X-linked disease that is characterized by intellectual disability, truncal obesity, seizures, hypogonadism, developmental delay, distinctive facial features, tapered fingers and short toes and has_material_basis_in X-linked recessive inheritance of mutations in the PHF6 gene.
imported from: doid.owl
has cross-reference: GARD:936
has cross-reference: MESH:C536575
has cross-reference: NCI:C157122
has cross-reference: OMIM:301900
has cross-reference: ORDO:127
has cross-reference: SNOMEDCT_US_2020_03_01:21634003
has cross-reference: UMLS_CUI:C0265339
alternative_term: BFLS
alternative_term: BORJ
alternative_term: Borjeson syndrome
alternative_term: MRXSBFL
alternative_term: intellectual deficiency-epilepsy-endocrine disorders syndrome
alternative_term: mental retardation, epilepsy, and endocrine disorder
alternative_term: syndromic X-linked mental retardation Borjeson-Forssman-Lehmann type
has_obo_namespace: disease_ontology
id: DOID:0050681
in subset: DO rare slim
comment: OMIM mapping confirmed by DO. [SN].

Bowen-Conradi syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by growth delays, failure to thrive and malformations of the head and face that results in infantile death, has_material_basis_in homozygous mutation in the EMG1 gene on chromosome 12p13.
imported from: doid.owl
has cross-reference: GARD:5950
has cross-reference: MESH:C537081
has cross-reference: OMIM:211180
has cross-reference: ORDO:1270
has cross-reference: SNOMEDCT_US_2020_03_01:711153001
has cross-reference: UMLS_CUI:C1859405
alternative_term: BWCNS
alternative_term: Bowen Hutterite syndrome
alternative_term: Bowen-Conradi Hutterite syndrome
has_obo_namespace: disease_ontology
id: DOID:0050684
comment: OMIM mapping confirmed by DO. [SN].

small cell carcinoma
type: Class
subclass of: carcinoma
textual definition: A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-13T01:25:14Z
has_alternative_id: DOID:7137
has cross-reference: NCI:C4099
has cross-reference: SNOMEDCT_US_2020_03_01:5958006
has cross-reference: UMLS_CUI:C0334239
alternative_term: Small cell carcinoma - intermediate cell
alternative_term: Small cell carcinoma, intermediate cell
alternative_term: intermediate cell small cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:0050685
in subset: NCIthesaurus

organ system cancer
type: Class
subclass of: cancer
textual definition: A cancer that is classified based on the organ it starts in.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-13T03:28:33Z
has cross-reference: MESH:D009371
has_obo_namespace: disease_ontology
id: DOID:0050686

cell type cancer
type: Class
subclass of: cancer
textual definition: A cancer that is classified by the type of cell from which it is derived.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-13T03:28:50Z
has_obo_namespace: disease_ontology
id: DOID:0050687
in subset: DO MGI slim

anal canal cancer
type: Class
subclass of: large intestine cancer
textual definition: A large intestine cancer that is located_in the terminal part of the large intestine.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-14T01:34:36Z
has_obo_namespace: disease_ontology
id: DOID:0050688

brachydactyly-syndactyly syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by brachydactyly and syndactyly, has_material_basis_in heterozygous mutation in the HOXD13 gene on chromosome 2q31.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-17T03:55:47Z
has cross-reference: MESH:C565193
has cross-reference: OMIM:610713
has_obo_namespace: disease_ontology
id: DOID:0050689
comment: OMIM mapping confirmed by DO. [SN].

brachyolmia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia characterized by generalized platyspondyly without significant long bone abnormalities and short stature.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-17T04:00:27Z
has cross-reference: GARD:10903
has cross-reference: OMIM:113500
has cross-reference: OMIM:271530
has cross-reference: OMIM:271630
has cross-reference: OMIM:613678
has cross-reference: ORDO:1293
alternative_term: brachyrachia
has_obo_namespace: disease_ontology
id: DOID:0050690
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

branchiooculofacial syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by low birth weight and growth retardation, bilateral branchial clefts.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-17T04:10:18Z
has cross-reference: GARD:3212
has cross-reference: OMIM:113620
has_obo_namespace: disease_ontology
id: DOID:0050691
comment: OMIM mapping confirmed by DO. [SN].

Brooke-Spiegler syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: skin disease
textual definition: A skin disease that is characterized by the development of several types of tumors from the skin, has_material_basis_in heterozygous mutation in the CYLD gene on chromosome 16q12.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-17T04:34:10Z
has cross-reference: GARD:10179
has cross-reference: OMIM:605041
has cross-reference: ORDO:79493
has cross-reference: SNOMEDCT_US_2020_03_01:703531009
has cross-reference: UMLS_CUI:C1857941
alternative_term: BRSS
alternative_term: BSS
alternative_term: CYLD cutaneous syndrome
alternative_term: SBS
alternative_term: Spiegler-Brooke Syndrome
has_obo_namespace: disease_ontology
id: DOID:0050693
comment: OMIM mapping confirmed by DO. [SN].

Brown-Vialetto-Van Laere syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by sensorineural hearing loss and a variety of cranial nerve palsies, usually involving the motor components of the seventh and ninth to twelfth cranial nerves.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-17T04:38:07Z
has cross-reference: MESH:C537111
has cross-reference: OMIM:PS211530
has_obo_namespace: disease_ontology
id: DOID:0050694
comment: OMIM mapping confirmed by DO. [SN].

fetal alcohol spectrum disorder
type: Class
subclass of: specific developmental disorder
textual definition: A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-12-01T01:01:25Z
has_obo_namespace: disease_ontology
id: DOID:0050696

chorioamnionitis
type: Class
subclass of: placenta disease
textual definition: A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-01-03T01:13:08Z
has cross-reference: MESH:D002821
has_obo_namespace: disease_ontology
id: DOID:0050697

funisitis
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-01-03T01:18:35Z
has_obo_namespace: disease_ontology
id: DOID:0050698

cardiomyopathy
type: Class
subclass of: heart disease
textual definition: A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-01-03T02:54:11Z
has cross-reference: ICD10CM:I42
has cross-reference: ICD9CM:425
has cross-reference: ICD9CM:425.9
has cross-reference: MESH:D009202
has cross-reference: NCI:C34830
has cross-reference: NCI:C53654
has cross-reference: SNOMEDCT_US_2020_03_01:266301006
has cross-reference: SNOMEDCT_US_2020_03_01:89461002
has cross-reference: SNOMEDCT_US_2020_03_01:89600009
has cross-reference: UMLS_CUI:C0033141
has cross-reference: UMLS_CUI:C0036529
has cross-reference: UMLS_CUI:C0878544
alternative_term: Cardiomyopathies
has_obo_namespace: disease_ontology
id: DOID:0050700
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: MESH:D009202 added from NeuroDevNet [WAK].

electroclinical syndrome
type: Class
subclass of: epilepsy
textual definition: An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-04-11T11:42:46Z
alternative_term: electro-clinical syndrome
has_obo_namespace: disease_ontology
id: DOID:0050701

neonatal period electroclinical syndrome
type: Class
subclass of: electroclinical syndrome
textual definition: An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-04-11T11:48:18Z
has_obo_namespace: disease_ontology
id: DOID:0050702
comment: JA:Epilepsy Genetics Kiel

infancy electroclinical syndrome
type: Class
subclass of: electroclinical syndrome
textual definition: An electroclinical syndrome with onset in infancy occurring between birth and one year of age.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-04-11T11:48:18Z
has_obo_namespace: disease_ontology
id: DOID:0050703
comment: JA:Epilepsy Genetics Kiel

childhood electroclinical syndrome
type: Class
subclass of: absence epilepsy
textual definition: An electroclinical syndrome with onset in childhood between one and 12 years of age.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-04-11T11:48:18Z
has_obo_namespace: disease_ontology
id: DOID:0050704
comment: JA:Epilepsy Genetics Kiel

adolescence-adult electroclinical syndrome
type: Class
subclass of: absence epilepsy
textual definition: An electroclinical syndrome with onset in adolescence and adulthood.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-04-11T11:48:18Z
has_obo_namespace: disease_ontology
id: DOID:0050705

variable age at onset electroclinical syndrome
type: Class
subclass of: electroclinical syndrome
textual definition: An electroclinial syndrome that is characterized by development of seizures later in life with a variable age of onset and duration.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-04-11T11:48:18Z
has_obo_namespace: disease_ontology
id: DOID:0050706

early onset absence epilepsy
type: Class
subclass of: childhood electroclinical syndrome
textual definition: A childhood electroclinical syndrome characterized by the occurrence of typical absence seizures starting between the age of four and ten years.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-04-11T02:29:04Z
has_obo_namespace: disease_ontology
id: DOID:0050708
comment: JA:Epilepsy Genetics Kiel

early infantile epileptic encephalopathy
type: Class
subclass of: neonatal period electroclinical syndrome
textual definition: A neonatal period electroclinical syndrome that is characterized by tonic spasms and partial seizures.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-05-10T10:02:58Z
has_alternative_id: DOID:2481
has cross-reference: GARD:9255
has cross-reference: OMIM:PS308350
has cross-reference: ORDO:1934
alternative_term: Early Infantile Epileptic Encephalopathy with Burst-Suppression
has_obo_namespace: disease_ontology
id: DOID:0050709

3-Methylcrotonyl-CoA carboxylase deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: muscular disease
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that is classified by inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-05-22T10:32:44Z
has cross-reference: GARD:10954
has cross-reference: OMIM:PS210200
has cross-reference: ORDO:6
alternative_term: 3-Methylcrotonylglycinuria
alternative_term: 3MCC deficiency
alternative_term: BMCC deficiency
has_obo_namespace: disease_ontology
id: DOID:0050710

aceruloplasminemia
type: Class
subclass of: autosomal recessive disease
subclass of: iron metabolism disease
textual definition: An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-05-22T11:47:25Z
has cross-reference: GARD:9499
has cross-reference: OMIM:604290
has_obo_namespace: disease_ontology
id: DOID:0050711

AGAT deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: cerebral creatine deficiency syndrome
textual definition: An amino acid metabolic disorder that has_material_basis_in a mutation in the GATM gene resulting in deficiency of arginine:glycine amidinotransferase which then limits creatine synthesis.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-05-22T11:53:57Z
has cross-reference: OMIM:612718
alternative_term: CEREBRAL CREATINE DEFICIENCY SYNDROME 3
alternative_term: arginine:glycine amidinotransferase deficiency
has_obo_namespace: disease_ontology
id: DOID:0050712

vitamin metabolic disorder
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-06-11T02:44:53Z
has_obo_namespace: disease_ontology
id: DOID:0050718

ornithine translocase deficiency
type: Class
subclass of: disease by infectious agent
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-06-13T03:09:31Z
has cross-reference: OMIM:238970
alternative_term: HHH syndrome
alternative_term: Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome
has_obo_namespace: disease_ontology
id: DOID:0050720

serine deficiency
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that has_material_basis_in defects in the biosynthesis of the amino acid L-serine.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-06-13T03:09:31Z
has_obo_namespace: disease_ontology
id: DOID:0050721

tyrosinemia type III
type: Class
subclass of: DOID 9275
textual definition: A tyrosinemia that has_material_basis_in deficiency of 4-hydroxyphenylpyruvate dioxygenase disrupting the break down of tyrosine.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-06T02:55:45Z
has cross-reference: OMIM:276710
has_obo_namespace: disease_ontology
id: DOID:0050727

glycogen metabolism disorder
type: Class
subclass of: carbohydrate metabolic disorder
textual definition: A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-13T10:42:54Z
has_obo_namespace: disease_ontology
id: DOID:0050728

neutral lipid storage disease
type: Class
subclass of: DOID 9455
textual definition: A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-17T12:31:48Z
has cross-reference: OMIM:275630
alternative_term: Chanarin-Dorfman syndrome
has_obo_namespace: disease_ontology
id: DOID:0050729

coenzyme Q10 deficiency disease
type: Class
subclass of: mitochondrial metabolism disease
textual definition: A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-17T12:58:37Z
has cross-reference: GARD:10423
has cross-reference: OMIM:PS607426
alternative_term: COENZYME Q10 DEFICIENCY, PRIMARY
has_obo_namespace: disease_ontology
id: DOID:0050730

vitamin B12 deficiency
type: Class
subclass of: vitamin metabolic disorder
textual definition: A vitamin metabolic disorder that results from low blood levels of vitamin B12.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-17T01:01:29Z
alternative_term: cobalamin deficiency
alternative_term: hypocobalaminemia
has_obo_namespace: disease_ontology
id: DOID:0050731

X-linked monogenic disease
type: Class
subclass of: monogenic disease
textual definition: A monogenic disease that has_material_basis_in muations in genes on the X chromosome.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-24T12:47:31Z
has_obo_namespace: disease_ontology
id: DOID:0050735
in subset: DO MGI slim

autosomal dominant disease
type: Class
subclass of: autosomal genetic disease
textual definition: An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-24T12:51:47Z
has_obo_namespace: disease_ontology
id: DOID:0050736

autosomal recessive disease
type: Class
subclass of: autosomal genetic disease
textual definition: An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-24T12:51:47Z
has_obo_namespace: disease_ontology
id: DOID:0050737

autosomal genetic disease
type: Class
subclass of: monogenic disease
textual definition: A monogenic disease that has_material_basis_in a mutation in a single gene on one of the non-sex chromosomes.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-07-24T04:45:53Z
has_obo_namespace: disease_ontology
id: DOID:0050739
in subset: DO MGI slim

alcohol dependence
type: Class
subclass of: DOID 9973
textual definition: A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-05T11:48:42Z
has cross-reference: EFO:0003829
has cross-reference: KEGG:05034
has cross-reference: OMIM:103780
has cross-reference: SNOMEDCT_US_2020_03_01:66590003
alternative_term: alcoholism
has_obo_namespace: disease_ontology
id: DOID:0050741
in subset: DO FlyBase slim
in subset: NCIthesaurus

nicotine dependence
type: Class
subclass of: DOID 9973
textual definition: A substance dependence that is characterized by a physical dependence on nicotine.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-05T11:48:42Z
has cross-reference: EFO:0003768
has cross-reference: ICD10CM:F17
has cross-reference: MESH:D014029
has cross-reference: NCI:C54203
has cross-reference: SNOMEDCT_US_2020_03_01:56294008
has cross-reference: UMLS_CUI:C0028043
alternative_term: tobacco use disorder
has_obo_namespace: disease_ontology
id: DOID:0050742
in subset: NCIthesaurus

mature T-cell and NK-cell lymphoma
type: Class
subclass of: non-Hodgkin lymphoma
textual definition: A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-18T01:56:52Z
alternative_term: NK-T cell lymphoma
alternative_term: mature T-cell and natural killer cell lymphoma
has_obo_namespace: disease_ontology
id: DOID:0050743
in subset: DO cancer slim

anaplastic large cell lymphoma
type: Class
subclass of: non-Hodgkin lymphoma
textual definition: A non-Hodgkin lymphoma involving aberrant T-cells.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-18T01:57:40Z
has_obo_namespace: disease_ontology
id: DOID:0050744

diffuse large B-cell lymphoma
type: Class
subclass of: B-cell lymphoma
textual definition: A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-18T01:58:25Z
has cross-reference: GARD:3178
has_obo_namespace: disease_ontology
id: DOID:0050745
in subset: DO cancer slim

mantle cell lymphoma
type: Class
subclass of: B-cell lymphoma
textual definition: A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-18T02:00:45Z
has cross-reference: GARD:6969
has cross-reference: MESH:D020522
has_obo_namespace: disease_ontology
id: DOID:0050746

marginal zone B-cell lymphoma
type: Class
subclass of: B-cell lymphoma
subclass of: DOID 9500
textual definition: A B-cell lymphoma that is characterized by initial formation in the marginal zones of lymph tissue.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-18T02:00:45Z
alternative_term: marginal zone lymphoma
has_obo_namespace: disease_ontology
id: DOID:0050748
in subset: DO cancer slim

peripheral T-cell lymphoma
type: Class
subclass of: mature T-cell and NK-cell lymphoma
textual definition: A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-18T02:01:49Z
has cross-reference: GARD:7368
has_obo_namespace: disease_ontology
id: DOID:0050749
in subset: DO cancer slim

splenic marginal zone lymphoma
type: Class
subclass of: marginal zone B-cell lymphoma
subclass of: spleen cancer
textual definition: A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp.
imported from: doid.owl
created_by: lschriml
creation_date: 2012-09-18T02:03:06Z
has_obo_namespace: disease_ontology
id: DOID:0050750

cerebellar ataxia
type: Class
subclass of: hereditary ataxia
subclass of: cerebellar disease
textual definition: A hereditary ataxia that is characterized by ataxia originating in the cerebellum.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-16T01:07:02Z
has cross-reference: MESH:D002524
has_obo_namespace: disease_ontology
id: DOID:0050753

ataxia with oculomotor apraxia type 2
type: Class
subclass of: autosomal recessive cerebellar ataxia
textual definition: An autosomal recessive cerebellar ataxia that is characterized by the onset of ataxia between age three and thirty including axonal sensorimotor neuropathy, oculomotor apraxia, cerebellar atrophy and elevated alpha-fetoprotein, has_material_basis_in homozygous or compound heterozygous mutation in the SETX gene on chromosome 9q34.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-16T01:07:02Z
has cross-reference: OMIM:606002
has_obo_namespace: disease_ontology
id: DOID:0050755

deafness-dystonia-optic neuronopathy syndrome
type: Class
subclass of: genetic disease
subclass of: mitochondrial metabolism disease
textual definition: A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems, and has_material_basis_in mutations in the TIMM8A gene resulting in abnormal protein transport within the mitochondria.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-16T01:20:50Z
has_alternative_id: DOID:0050867
has cross-reference: MESH:C535808
has cross-reference: OMIM:304700
has cross-reference: ORDO:3213
alternative_term: Deafness Dystonia Optic Atrophy Syndrome
alternative_term: Deafness Dystonia Optic Neuronopathy Syndrome
alternative_term: Dystonia Deafness Syndrome
alternative_term: Jensen syndrome
alternative_term: Mohr-Tranebjaerg Syndrome
alternative_term: Mohr-Tranebjaerg syndrome
alternative_term: deafness dystonia syndrome
has_obo_namespace: disease_ontology
id: DOID:0050757

metabolic acidosis
type: Class
subclass of: acquired metabolic disease
textual definition: An acquired metabolic disease that characterized by excessive production of acid.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-16T01:23:37Z
has_obo_namespace: disease_ontology
id: DOID:0050758

myotonic dystrophy type 2
type: Class
subclass of: myotonic disease
textual definition: A myotonic disease that is characterized by myotonia and progressive, proximal muscle wasting and weakness affecting the skeletal and smooth muscles of the neck, shoulders, elbows and hips and has_material_basis_in the autosomal dominant inheritance of the CNBP (ZNF9) gene containing an expansion of a CCTG repeat in intron one.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-16T01:27:31Z
has cross-reference: GARD:9728
has cross-reference: ICD10CM:G71.1
has cross-reference: ICD10CM:G71.19
has cross-reference: ICD9CM:359.2
has cross-reference: MESH:D020967
has cross-reference: NCI:C122789
has cross-reference: NCI:C122790
has cross-reference: NCI:C84913
has cross-reference: OMIM:602668
has cross-reference: SNOMEDCT_US_2020_03_01:155096007
has cross-reference: SNOMEDCT_US_2020_03_01:41574007
has cross-reference: SNOMEDCT_US_2020_03_01:715788001
has cross-reference: UMLS_CUI:C0221055
has cross-reference: UMLS_CUI:C0553604
has cross-reference: UMLS_CUI:C0752355
alternative_term: proximal myotonic myopathy
has_obo_namespace: disease_ontology
id: DOID:0050759
in subset: NCIthesaurus
has narrower match: MESH:C535686

ARC syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by congenital joint contractures, renal tubular dysfunction, cholestasis, severe failure to thrive, ichthyosis and a defect in platelet alpha-granule biogenesis and that has_material_basis_in homozygous or compound heterozygous mutation in the VPS33B gene or homozygous or compound heterozygous mutation in the VIPAR gene on chromosome 14q24.3.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-17T12:46:38Z
has cross-reference: OMIM:PS208085
has cross-reference: ORDO:2697
alternative_term: ARTHROGRYPOSIS, RENAL DYSFUNCTION, AND CHOLESTASIS
alternative_term: Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome
alternative_term: Arthrogryposis-renal dysfunction-cholestasis
has_obo_namespace: disease_ontology
id: DOID:0050763
in subset: DO FlyBase slim

neuroacanthocytosis
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease that is characterized by characterized by misshapen, spiny red blood cells (acanthocytosis) and neurological abnormalities, especially movement disorders.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-17T12:54:19Z
has cross-reference: GARD:10902
has cross-reference: MESH:D054546
has cross-reference: ORDO:263440
has_obo_namespace: disease_ontology
id: DOID:0050765

choreaacanthocytosis
type: Class
subclass of: autosomal recessive disease
subclass of: neuroacanthocytosis
textual definition: A neuroacanthocytosis characterized by progressive neurodegeneration and red cell acanthocytosis, with onset in the third to fifth decade of life and has_material_basis_in homozygous or compound heterozygous mutation in the VPS13A gene, which encodes chorein, on chromosome 9q21.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-01-17T12:54:19Z
has cross-reference: GARD:3956
has cross-reference: MESH:D054546
has cross-reference: NCI:C84926
has cross-reference: OMIM:200150
has cross-reference: ORDO:2388
has cross-reference: SNOMEDCT_US_2020_03_01:26848004
has cross-reference: UMLS_CUI:C0393576
alternative_term: Levine-Critchley syndrome
alternative_term: choreo-acanthocytosis
has_obo_namespace: disease_ontology
id: DOID:0050766
in subset: NCIthesaurus

N syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by intellectual disability, deafness, ocular abnormalities, T-cell leukemia, cryptorchidism, hypospadias and spasticity.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-02-21T11:32:26Z
has cross-reference: GARD:3902
has cross-reference: OMIM:310465
has cross-reference: ORDO:2608
alternative_term: NSX
has_obo_namespace: disease_ontology
id: DOID:0050769

polycystic liver disease
type: Class
subclass of: autosomal dominant disease
subclass of: liver disease
textual definition: A liver disease that is characterized by the presence of multiple cysts located_in the liver.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-02-21T11:36:13Z
has_alternative_id: DOID:1173
has cross-reference: GARD:9457
has cross-reference: OMIM:174050
alternative_term: congenital cystic liver disease
alternative_term: congenital hepatic cyst
alternative_term: fibrocystic liver disease
has_obo_namespace: disease_ontology
id: DOID:0050770

pheochromocytoma
type: Class
subclass of: endocrine organ benign neoplasm
textual definition: An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-02-21T11:40:58Z
has cross-reference: GARD:7385
has cross-reference: MESH:D010673
has cross-reference: OMIM:171300
alternative_term: phaeochromocytoma
has_obo_namespace: disease_ontology
id: DOID:0050771

paraganglioma
type: Class
subclass of: autosomal dominant disease
subclass of: pheochromocytoma
textual definition: A pheochromocytoma that arises in extraadrenal sympathetic ganglia.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-02-21T11:51:57Z
has cross-reference: MESH:D010235
has cross-reference: NCI:C3308
has cross-reference: OMIM:115310
has cross-reference: OMIM:168000
has cross-reference: OMIM:601650
has cross-reference: OMIM:605373
has cross-reference: OMIM:614165
has cross-reference: OMIM:PS168000
has cross-reference: SNOMEDCT_US_2020_03_01:302833002
has cross-reference: UMLS_CUI:C0030421
alternative_term: chemodectoma
alternative_term: glomus body tumor
has_obo_namespace: disease_ontology
id: DOID:0050773
in subset: NCIthesaurus
comment: Xref MGI.

rapadilino syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by radial ray defect, patellae hypoplasia, cleft palate, diarrhea, dislocated joints, limb malformations, long nose and normal intelligence, has_material_basis_in homozygous or compound heterozygous mutation in the DNA helicase gene RECQL4 on chromosome 8q24.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-02-21T11:56:15Z
has cross-reference: GARD:4637
has cross-reference: MESH:C535288
has cross-reference: OMIM:266280
has cross-reference: ORDO:3021
has cross-reference: SNOMEDCT_US_2020_03_01:702413000
has cross-reference: UMLS_CUI:C1849453
has_obo_namespace: disease_ontology
id: DOID:0050774

schneckenbecken dysplasia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that is characterized by hypoplastic iliac bones, hypoplastic vertebral bodies, short ribs and broad long bones, prenatally lethal, has_material_basis_in homozygous or compound heterozygous mutation in the SLC35D1 gene on chromosome 1p31.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-02-21T12:00:39Z
has cross-reference: GARD:169
has cross-reference: MESH:C536637
has cross-reference: OMIM:269250
has_obo_namespace: disease_ontology
id: DOID:0050775

non-syndromic X-linked intellectual disability
type: Class
subclass of: X-linked monogenic disease
subclass of: non-syndromic intellectual disability
textual definition: A non-syndromic intellectual disability characterized by a X-linked inheritance pattern.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-02-21T12:06:40Z
has cross-reference: OMIM:300716
has cross-reference: OMIM:PS309530
has cross-reference: ORDO:777
alternative_term: non-specific X-linked mental retardation
has_obo_namespace: disease_ontology
id: DOID:0050776
in subset: DO FlyBase slim
in subset: DO rare slim
comment: Xref MGI.

cerebral creatine deficiency syndrome
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that is characterized by mental retardation, severe speech delay, behavioral abnormalities and seizures, has_material_basis_in mutation in the creatine transporter gene on chromosome Xq28.
imported from: doid.owl
created_by: lschriml
creation_date: 2013-11-21T12:10:58Z
has_obo_namespace: disease_ontology
id: DOID:0050798

atrioventricular block
type: Class
subclass of: heart conduction disease
textual definition: A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-02-12T01:35:05Z
has cross-reference: ICD10CM:I44.3
has cross-reference: ICD9CM:426.10
has cross-reference: MESH:D054537
has cross-reference: NCI:C26703
has cross-reference: SNOMEDCT_US_2020_03_01:58547007
has cross-reference: UMLS_CUI:C0004245
alternative_term: AV block
has_obo_namespace: disease_ontology
id: DOID:0050820
in subset: NCIthesaurus

sinoatrial node disease
type: Class
subclass of: muscular disease
subclass of: heart conduction disease
textual definition: A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-02-12T01:47:54Z
alternative_term: SA node
alternative_term: sinuatrial node
has_obo_namespace: disease_ontology
id: DOID:0050824

endocardium disease
type: Class
subclass of: heart disease
textual definition: A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-02-12T01:53:42Z
has_obo_namespace: disease_ontology
id: DOID:0050825

tricuspid valve disease
type: Class
subclass of: heart valve disease
textual definition: A heart valve disease that is characterized by valvular insufficiency or valvular stenosis, located_in tricuspid valve between the right atrium and right ventricle.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-02-12T02:55:24Z
has_alternative_id: DOID:13834
has cross-reference: ICD10CM:I07
has cross-reference: ICD9CM:397.0
has cross-reference: SNOMEDCT_US_2020_03_01:49699002
has cross-reference: UMLS_CUI:C0264776
alternative_term: RH. tricuspid valve disease
alternative_term: Rheumatic disease of tricuspid valve
alternative_term: Rheumatic tricuspid valve disease
alternative_term: Tricuspid disease
alternative_term: disease of tricuspid valve
alternative_term: rheumatic tricuspid valve disease
has_obo_namespace: disease_ontology
id: DOID:0050826

artery disease
type: Class
subclass of: vascular disease
textual definition: A vascular disease that is located_in an artery.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-02-12T03:08:35Z
has_obo_namespace: disease_ontology
id: DOID:0050828

pericardium disease
type: Class
subclass of: cardiovascular system disease
textual definition: A cardiovascular system disease that is located_in the fibrous sac surrounding the heart.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-02-18T12:20:15Z
has_obo_namespace: disease_ontology
id: DOID:0050829

focal dystonia
type: Class
subclass of: dystonia
textual definition: A dystonia that is localized to a specific part of the body.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-03-18T01:13:36Z
has cross-reference: GARD:6458
has_obo_namespace: disease_ontology
id: DOID:0050836

cranio-facial dystonia
type: Class
subclass of: focal dystonia
textual definition: A focal dystonia that is characterized as dystonia that affects the muscles of the head, face, and neck.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-03-18T01:33:33Z
has_obo_namespace: disease_ontology
id: DOID:0050845

sleep apnea
type: Class
subclass of: sleep disorder
textual definition: A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-03-20T03:57:22Z
has cross-reference: ICD10CM:G47.3
has cross-reference: ICD9CM:780.57
has cross-reference: MESH:D012891
has cross-reference: NCI:C26884
has cross-reference: SNOMEDCT_US_2020_03_01:206750008
has cross-reference: UMLS_CUI:C0037315
has_obo_namespace: disease_ontology
id: DOID:0050847
in subset: NCIthesaurus

glomerulosclerosis
type: Class
subclass of: glomerulonephritis
textual definition: A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-04-15T03:40:31Z
has_obo_namespace: disease_ontology
id: DOID:0050851

syndromic intellectual disability
type: Class
subclass of: intellectual disability
textual definition: An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-08-14T10:55:32Z
has_obo_namespace: disease_ontology
id: DOID:0050888
in subset: DO FlyBase slim

non-syndromic intellectual disability
type: Class
subclass of: intellectual disability
textual definition: An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-08-14T10:57:36Z
has cross-reference: OMIM:613192
has cross-reference: OMIM:614202
has_obo_namespace: disease_ontology
id: DOID:0050889

synucleinopathy
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-08-14T03:29:17Z
alternative_term: Synucleinopathies
alternative_term: alpha Synucleinopathies
has_obo_namespace: disease_ontology
id: DOID:0050890
in subset: DO FlyBase slim

medulloblastoma
type: Class
subclass of: infratentorial cancer
textual definition: An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-10-06T14:36:37Z
has_alternative_id: DOID:0060105
has_alternative_id: DOID:168
has_alternative_id: DOID:3858
has_alternative_id: DOID:4981
has cross-reference: GARD:7005
has cross-reference: MESH:D008527
has cross-reference: MESH:D018242
has cross-reference: NCI:C27294
has cross-reference: NCI:C3222
has cross-reference: NCI:C3716
has cross-reference: OMIM:155255
has cross-reference: SNOMEDCT_US_2020_03_01:189925001
has cross-reference: SNOMEDCT_US_2020_03_01:443333004
has cross-reference: UMLS_CUI:C0025149
has cross-reference: UMLS_CUI:C0206663
has cross-reference: UMLS_CUI:C1334410
alternative_term: CNS PNET
alternative_term: CPNET
alternative_term: brain medulloblastoma
alternative_term: infratentorial primitive neuroectodermal tumor
alternative_term: localized primitive neuroectodermal tumor
has_obo_namespace: disease_ontology
id: DOID:0050902
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

salivary gland carcinoma
type: Class
subclass of: carcinoma
subclass of: DOID 8850
textual definition: A salivary gland cancer that has_material_basis_in epithelial cells.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-10-08T16:52:58Z
has_obo_namespace: disease_ontology
id: DOID:0050904
in subset: DO cancer slim

breast lobular carcinoma
type: Class
subclass of: breast carcinoma
textual definition: A breast carcinoma that derives_from breast lobules (milk glands).
imported from: doid.owl
created_by: lschriml
creation_date: 2014-10-22T13:05:34Z
has_obo_namespace: disease_ontology
id: DOID:0050938
in subset: DO cancer slim

autosomal recessive cerebellar ataxia
type: Class
subclass of: autosomal recessive disease
subclass of: cerebellar ataxia
textual definition: A cerebellar ataxia that has_material_basis_in autosomal recessive inheritance.
imported from: doid.owl
created_by: lschriml
creation_date: 2015-10-05T14:21:08Z
has cross-reference: OMIM:PS213200
has cross-reference: ORDO:1172
has_obo_namespace: disease_ontology
id: DOID:0050950

hereditary ataxia
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements.
imported from: doid.owl
created_by: lschriml
creation_date: 2015-10-05T14:38:17Z
has cross-reference: GARD:6614
has_obo_namespace: disease_ontology
id: DOID:0050951

infective endocarditis
type: Class
subclass of: disease by infectious agent
subclass of: endocarditis
textual definition: An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.
imported from: doid.owl
has cross-reference: GARD:6337
has_obo_namespace: disease_ontology
id: DOID:0060000

withdrawal disorder
type: Class
subclass of: substance-related disorder
textual definition: A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060001

C1 inhibitor deficiency
type: Class
subclass of: complement deficiency
textual definition: A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue.
imported from: doid.owl
alternative_term: Quincke edema
has_obo_namespace: disease_ontology
id: DOID:0060002

autoimmune disease of central nervous system
type: Class
subclass of: autoimmune disease of the nervous system
textual definition: An autoimmune hypersensitivity disease located_in the central nervous system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060004

autoimmune disease of endocrine system
type: Class
subclass of: endocrine system disease
subclass of: autoimmune disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060005

MHC class I deficiency
type: Class
subclass of: severe combined immunodeficiency
textual definition: A severe combined immunodeficiency that is characterized by recurrent bacterial, viral, and fungal infections, especially of the lung, and sterile necrotizing granulomas of the skin, develops_from deficiency or decreased surface expression of MHC Class I, has_material_basis_in autosomal recessive inheritance of mutation affecting MHC Class I production or expression and frequently involves TAP1 and TAP2 subunits, and is typically asymptomatic in infancy.
imported from: doid.owl
has cross-reference: OMIM:604571
alternative_term: BLS, TYPE I
alternative_term: BLSI
alternative_term: HLA CLASS I DEFICIENCY
alternative_term: bare lymphocyte syndrome type I
has_obo_namespace: disease_ontology
id: DOID:0060009
comment: OMIM mapping confirmed by DO. [SN].

Omenn syndrome
type: Class
subclass of: severe combined immunodeficiency
textual definition: A severe combined immunodeficiency that has_material_basis in the RAG1 and RAG2 genes on chromosome 11p and the Artemis gene on chromosome 10p. It is characterized by erythroderma, desquamation, alopecia, chronic diarrhea, failure to thrive, lymphadenopathy, and hepatosplenomegaly.
imported from: doid.owl
has cross-reference: GARD:8198
has cross-reference: ICD10CM:D81.8
has cross-reference: OMIM:603554
alternative_term: combined immunodeficiency with hypereosinophilia
has_obo_namespace: disease_ontology
id: DOID:0060010

X-linked severe combined immunodeficiency
type: Class
subclass of: X-linked recessive disease
subclass of: severe combined immunodeficiency
textual definition: A severe combined immunodeficiency that is a X-linked SCID that has_material_basis_in mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.
imported from: doid.owl
has_alternative_id: DOID:5811
has cross-reference: GARD:5618
has cross-reference: MESH:D053632
has cross-reference: NCI:C4682
has cross-reference: OMIM:300400
has cross-reference: SNOMEDCT_US_2020_03_01:203592006
has cross-reference: UMLS_CUI:C1279481
alternative_term: SCID-X1
alternative_term: X-Linked Severe Combined Immunodeficiency
alternative_term: XSCID
alternative_term: gamma chain deficiency
alternative_term: thymic epithelial hypoplasia
has_obo_namespace: disease_ontology
id: DOID:0060013
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

coronin-1A deficiency
type: Class
subclass of: severe combined immunodeficiency
textual definition: A severe combined immunodeficiency that is an actin regulator when mutated results in SCID through inhibition of thymic egress of mature thymocytes into peripheral lymphoid organs.
imported from: doid.owl
has cross-reference: OMIM:615401
has_obo_namespace: disease_ontology
id: DOID:0060019

reticular dysgenesis
type: Class
subclass of: autosomal recessive disease
subclass of: severe combined immunodeficiency
textual definition: A severe combined immunodeficiency that is the most severe form of SCID and has_material_basis_in mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.
imported from: doid.owl
has_alternative_id: DOID:1226
has cross-reference: GARD:8625
has cross-reference: MESH:C538361
has cross-reference: NCI:C27070
has cross-reference: OMIM:267500
has cross-reference: SNOMEDCT_US_2020_03_01:111584000
has cross-reference: UMLS_CUI:C0272167
alternative_term: De Vaal disease
has_obo_namespace: disease_ontology
has_related_synonym: aleukocytosis
id: DOID:0060020
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

DNA ligase IV deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: combined T cell and B cell immunodeficiency
textual definition: A combined T cell and B cell immunodeficiency that has_material_basis_in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.
imported from: doid.owl
has cross-reference: OMIM:606593
alternative_term: LIG4 Syndrome
has_obo_namespace: disease_ontology
id: DOID:0060021
comment: OMIM mapping confirmed by DO. [SN].

CD40 ligand deficiency
type: Class
subclass of: X-linked recessive disease
subclass of: combined T cell and B cell immunodeficiency
textual definition: A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.
imported from: doid.owl
has cross-reference: OMIM:308230
alternative_term: HIGMX-1
alternative_term: X-linked hyper-IgM syndrome
has_obo_namespace: disease_ontology
id: DOID:0060022

immunoglobulin alpha deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: B cell deficiency
textual definition: A B cell deficiency that is an autosomal recessive disorder that has_material_basis_in mutation in the IgA (CD79 alpha) antigen receptor.
imported from: doid.owl
has cross-reference: GARD:10197
has cross-reference: MESH:D017098
has cross-reference: OMIM:137100
has cross-reference: OMIM:269650
has cross-reference: OMIM:609529
has cross-reference: ORDO:69127
has cross-reference: SNOMEDCT_US_2020_03_01:29260007
has cross-reference: UMLS_CUI:C0162538
alternative_term: IgA deficiency
alternative_term: gamma-A-globulin deficiency
has_obo_namespace: disease_ontology
id: DOID:0060025
in subset: DO rare slim
comment: Xref MGI.

Good syndrome
type: Class
subclass of: combined T cell and B cell immunodeficiency
textual definition: A combined T cell and B cell immunodeficiency that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma.
imported from: doid.owl
alternative_term: thymoma with hypogammaglobulinemia
has_obo_namespace: disease_ontology
id: DOID:0060028

autoimmune disease of exocrine system
type: Class
subclass of: autoimmune disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the exocrine system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060029

autoimmune disease of gastrointestinal tract
type: Class
subclass of: autoimmune disease
subclass of: gastrointestinal system disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060031

autoimmune disease of musculoskeletal system
type: Class
subclass of: musculoskeletal system disease
subclass of: autoimmune disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060032

autoimmune disease of peripheral nervous system
type: Class
subclass of: autoimmune disease of the nervous system
subclass of: peripheral nervous system disease
textual definition: An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060033

intrinsic cardiomyopathy
type: Class
subclass of: cardiomyopathy
textual definition: A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060036

developmental disorder of mental health
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060037

specific developmental disorder
type: Class
subclass of: developmental disorder of mental health
textual definition: A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060038

autoimmune disease of skin and connective tissue
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: skin disease
subclass of: connective tissue disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060039

pervasive developmental disorder
type: Class
subclass of: developmental disorder of mental health
textual definition: A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.
imported from: doid.owl
has_alternative_id: DOID:1208
has cross-reference: ICD9CM:299.80
has cross-reference: UMLS_CUI:C0154451
alternative_term: pervasive development disorder
has_obo_namespace: disease_ontology
id: DOID:0060040

autism spectrum disorder
type: Class
subclass of: pervasive developmental disorder
textual definition: A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.
imported from: doid.owl
has cross-reference: GARD:10248
has cross-reference: MESH:D000067877
has_obo_namespace: disease_ontology
id: DOID:0060041
in subset: DO FlyBase slim

atypical autism
type: Class
subclass of: autism spectrum disorder
textual definition: An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism.
imported from: doid.owl
alternative_term: PDD
has_obo_namespace: disease_ontology
id: DOID:0060042

sexual disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that involves the impairment in normal sexual functioning.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060043

paraphilia disorder
type: Class
subclass of: sexual disorder
textual definition: A sexual disorder that is characterized recurrent, intense sexually arousing fantasies, sexual urges or behaviors generally involving nonhuman objects.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060044

aphasia
type: Class
subclass of: DOID 93
textual definition: A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060046

writing disorder
type: Class
subclass of: DOID 8927
textual definition: A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060047

autoimmune disease of urogenital tract
type: Class
subclass of: autoimmune disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060049

autoimmune disease of blood
type: Class
subclass of: autoimmune disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060050
in subset: DO FlyBase slim

autoimmune disease of cardiovascular system
type: Class
subclass of: cardiovascular system disease
subclass of: autoimmune disease
textual definition: An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060051

hypersensitivity reaction disease
type: Class
subclass of: immune system disease
textual definition: An immune system disease that has_material_basis_in abnormal immune responses.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060056

lymphoma
type: Class
subclass of: lymphatic system cancer
subclass of: hematologic cancer
textual definition: A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.
imported from: doid.owl
has_alternative_id: DOID:1033
has_alternative_id: DOID:353
has cross-reference: ICD10CM:C85.9
has cross-reference: MESH:D008223
has cross-reference: NCI:C3208
has cross-reference: NCI:C7065
has cross-reference: SNOMEDCT_US_2020_03_01:118600007
has cross-reference: SNOMEDCT_US_2020_03_01:414628006
has cross-reference: UMLS_CUI:C0024299
has cross-reference: UMLS_CUI:C0598798
alternative_term: lymphoid cancer
has_obo_namespace: disease_ontology
id: DOID:0060058
in subset: DO cancer slim
in subset: NCIthesaurus

non-Hodgkin lymphoma
type: Class
subclass of: lymphoma
textual definition: A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma.
imported from: doid.owl
has cross-reference: MESH:D008228
has cross-reference: OMIM:605027
has cross-reference: ORDO:547
has_obo_namespace: disease_ontology
id: DOID:0060060
comment: OMIM mapping confirmed by DO. [LS].

cutaneous T cell lymphoma
type: Class
subclass of: peripheral T-cell lymphoma
textual definition: A non-Hodgkin's lymphoma that has_material_basis_in a mutation of T cells.
imported from: doid.owl
has cross-reference: GARD:6226
has cross-reference: MESH:D016410
alternative_term: cutaneous T-cell lymphoma
has_obo_namespace: disease_ontology
id: DOID:0060061
in subset: DO rare slim

familial juvenile hyperuricemic nephropathy
type: Class
subclass of: kidney disease
textual definition: A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease.
imported from: doid.owl
has cross-reference: OMIM:162000
has cross-reference: OMIM:613092
has cross-reference: OMIM:614227
has cross-reference: ORDO:209886
has cross-reference: ORDO:217330
has_obo_namespace: disease_ontology
id: DOID:0060062
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [LS].

pyridoxine-responsive sideroblastic anemia
type: Class
subclass of: DOID 8955
textual definition: A sideoblastic anemia that is characterized by the presence of microcytic hypochromic anemia and iron overload, and has_material_basis_in X-linked inheritance.
imported from: doid.owl
has cross-reference: OMIM:206000
has_obo_namespace: disease_ontology
id: DOID:0060066
comment: OMIM mapping confirmed by DO. [LS].

Pearson syndrome
type: Class
subclass of: mitochondrial metabolism disease
textual definition: A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction.
imported from: doid.owl
has cross-reference: GARD:7343
has cross-reference: OMIM:557000
alternative_term: Pearson Marrow-Pancreas Syndrome
has_obo_namespace: disease_ontology
id: DOID:0060067
comment: OMIM mapping confirmed by DO. [LS].

pre-malignant neoplasm
type: Class
subclass of: disease of cellular proliferation
textual definition: A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-05-11T12:18:41Z
has_obo_namespace: disease_ontology
id: DOID:0060071
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

benign neoplasm
type: Class
subclass of: disease of cellular proliferation
textual definition: A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-05-11T12:18:41Z
has_obo_namespace: disease_ontology
id: DOID:0060072
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

lymphatic system cancer
type: Class
subclass of: immune system cancer
subclass of: lymphatic system disease
textual definition: An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-05-11T01:05:14Z
has_obo_namespace: disease_ontology
id: DOID:0060073

ductal carcinoma in situ
type: Class
subclass of: DOID 8791
textual definition: A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-06-08T12:19:28Z
has_obo_namespace: disease_ontology
id: DOID:0060074

estrogen-receptor positive breast cancer
type: Class
subclass of: breast cancer
textual definition: A breast cancer that is characterized by the presence of estrogen receptors.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-06-08T12:23:02Z
has_obo_namespace: disease_ontology
id: DOID:0060075

breast benign neoplasm
type: Class
subclass of: thoracic benign neoplasm
subclass of: breast disease
textual definition: A thoracic benign neoplasm that is characterized by lack of malignancy.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-06-08T01:02:29Z
has_obo_namespace: disease_ontology
id: DOID:0060082

immune system cancer
type: Class
subclass of: organ system cancer
subclass of: immune system disease
textual definition: An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-06-08T01:11:18Z
has_obo_namespace: disease_ontology
id: DOID:0060083

cell type benign neoplasm
type: Class
subclass of: benign neoplasm
textual definition: A benign neoplasm that is classified by the type of cell or tissue from which it is derived.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-14T11:59:48Z
has_obo_namespace: disease_ontology
id: DOID:0060084

organ system benign neoplasm
type: Class
subclass of: benign neoplasm
textual definition: A benign neoplasm that is classified by the organ system from which it is arising from.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-14T12:12:23Z
has_obo_namespace: disease_ontology
id: DOID:0060085
in subset: DO FlyBase slim

female reproductive organ benign neoplasm
type: Class
subclass of: reproductive organ benign neoplasm
subclass of: female reproductive system disease
textual definition: A reproductive organ benign neoplasm that is characterized by a lack of malignancy located_in the female reproductive system.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-14T12:20:52Z
has_obo_namespace: disease_ontology
id: DOID:0060086

male reproductive organ benign neoplasm
type: Class
subclass of: reproductive organ benign neoplasm
subclass of: male reproductive system disease
textual definition: A reproductive organ benign neoplasm that is characterized by a lack of malignancy located_in the male reproductive system.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-14T12:20:52Z
has_obo_namespace: disease_ontology
id: DOID:0060087

endocrine organ benign neoplasm
type: Class
subclass of: organ system benign neoplasm
textual definition: An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-14T01:45:15Z
has_obo_namespace: disease_ontology
id: DOID:0060089

central nervous system benign neoplasm
type: Class
subclass of: nervous system benign neoplasm
subclass of: central nervous system disease
textual definition: A nervous system benign neoplasm that is characterized by lack of malignancy.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-14T01:45:15Z
has_obo_namespace: disease_ontology
id: DOID:0060090

cardiovascular organ benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: cardiovascular system disease
textual definition: An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-14T01:45:15Z
has_obo_namespace: disease_ontology
id: DOID:0060091

bone benign neoplasm
type: Class
subclass of: connective tissue benign neoplasm
subclass of: bone disease
textual definition: A connective tissue benign neoplasm that is located_in bone.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-15T01:34:59Z
has_obo_namespace: disease_ontology
id: DOID:0060094

uterine benign neoplasm
type: Class
subclass of: female reproductive organ benign neoplasm
subclass of: uterine disease
textual definition: A female reproductive organ benign neoplasm that is located_in the uterus.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-15T01:42:11Z
has_alternative_id: DOID:0060113
has_obo_namespace: disease_ontology
id: DOID:0060095

sensory organ benign neoplasm
type: Class
subclass of: sensory system disease
subclass of: nervous system benign neoplasm
textual definition: A nervous system benign neoplasm that is located_in a sensory organ.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-15T01:45:26Z
has_obo_namespace: disease_ontology
id: DOID:0060096

thoracic benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: thoracic disease
textual definition: An organ system benign neoplam that is located_in the thoracic cavity.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-15T01:55:57Z
has_obo_namespace: disease_ontology
id: DOID:0060097

osteoblastoma
type: Class
subclass of: bone benign neoplasm
textual definition: A bone benign neoplasm of the bone that is characterized by clinical and histological similarity to osteoid osteomas.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-15T02:14:40Z
has cross-reference: MESH:D018215
has_obo_namespace: disease_ontology
id: DOID:0060098

musculoskeletal system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: musculoskeletal system disease
textual definition: An organ system benign neoplasm that is located_in the muscular and skeletal organs.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-15T02:28:52Z
has_obo_namespace: disease_ontology
id: DOID:0060099

musculoskeletal system cancer
type: Class
subclass of: organ system cancer
subclass of: musculoskeletal system disease
textual definition: An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-15T02:30:51Z
has_alternative_id: DOID:0060124
alternative_term: skeletal system cancer
has_obo_namespace: disease_ontology
id: DOID:0060100

benign glioma
type: Class
subclass of: cell type benign neoplasm
subclass of: central nervous system benign neoplasm
subclass of: spinal cord disease
subclass of: DOID 936
textual definition: A cell type benign neoplasm that has_material_basis_in glial cells.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-19T01:27:04Z
has_obo_namespace: disease_ontology
id: DOID:0060101

central nervous system primitive neuroectodermal neoplasm
type: Class
subclass of: neuroectodermal tumor
subclass of: central nervous system cancer
textual definition: A central nervous system cancer of children and young adults that develops from neural crest cells located_in cerebrum, has_material_basis_in abnormally proliferating cells derives_from neuroectoderm.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-21T02:24:10Z
has_obo_namespace: disease_ontology
id: DOID:0060103
in subset: DO cancer slim

brain glioma
type: Class
subclass of: brain cancer
textual definition: A brain cancer that has_material_basis_in glial cells.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-22T12:42:50Z
alternative_term: lower grade glioma
has_obo_namespace: disease_ontology
id: DOID:0060108
in subset: DO FlyBase slim
in subset: DO cancer slim

vulvar benign neoplasm
type: Class
subclass of: female reproductive organ benign neoplasm
subclass of: vulvar disease
textual definition: A female reproductive organ benign neoplasm that is located_in the vulva.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-25T11:50:50Z
has_obo_namespace: disease_ontology
id: DOID:0060109

ovarian benign neoplasm
type: Class
subclass of: female reproductive organ benign neoplasm
subclass of: ovarian disease
textual definition: A female reproductive organ benign neoplasm that is located_in the ovary.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-25T11:50:50Z
has_obo_namespace: disease_ontology
id: DOID:0060112

nervous system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: DOID 863
textual definition: An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-25T12:47:43Z
has_obo_namespace: disease_ontology
id: DOID:0060115

sensory system cancer
type: Class
subclass of: sensory system disease
subclass of: nervous system cancer
textual definition: A nervous system cancer that is located in the sensory system.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-25T01:51:56Z
has_obo_namespace: disease_ontology
id: DOID:0060116

thoracic disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in the thoracic cavity.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-25T02:23:47Z
has_obo_namespace: disease_ontology
id: DOID:0060118
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

pharynx cancer
type: Class
subclass of: gastrointestinal system cancer
textual definition: A gastrointestinal system cancer that is located_in the pharynx.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-27T01:26:34Z
has cross-reference: MESH:D010610
has cross-reference: NCI:C3325
has cross-reference: SNOMEDCT_US_2020_03_01:126685009
has cross-reference: UMLS_CUI:C0031347
alternative_term: pharyngeal neoplasm
alternative_term: pharynx neoplasm
has_obo_namespace: disease_ontology
has_related_synonym: pharyngeal cancer
id: DOID:0060119
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

integumentary system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: integumentary system disease
textual definition: An organ system benign neoplasm located_in the integumentary system organs.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-27T01:49:44Z
has_obo_namespace: disease_ontology
id: DOID:0060121

integumentary system cancer
type: Class
subclass of: organ system cancer
subclass of: integumentary system disease
textual definition: An organ system cancer that is located_in the skin, hair and nails.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-27T02:31:34Z
has_obo_namespace: disease_ontology
id: DOID:0060122

connective tissue benign neoplasm
type: Class
subclass of: musculoskeletal system benign neoplasm
subclass of: connective tissue disease
textual definition: A musculoskeletal system benign neoplasm that is located_in connective tissue.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-27T02:35:57Z
has_alternative_id: DOID:177
has cross-reference: MESH:D012983
has cross-reference: NCI:C3377
has cross-reference: SNOMEDCT_US_2020_03_01:126600002
has cross-reference: UMLS_CUI:C0037579
alternative_term: neoplasm of soft tissue
alternative_term: neoplasm of soft tissues
alternative_term: soft tissue benign neoplasm
alternative_term: tumor of the soft tissue
has_obo_namespace: disease_ontology
id: DOID:0060123
in subset: NCIthesaurus

heavy chain disease
type: Class
subclass of: hypersensitivity reaction type IV disease
textual definition: A hypersensitivity reaction type IV disease that results from a proliferation of cells producing immunoglobulin heavy chains.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T11:23:09Z
has cross-reference: ICD10CM:C88.2
has cross-reference: MESH:D006362
has cross-reference: NCI:C3082
has cross-reference: NCI:C3083
has cross-reference: NCI:C3892
has cross-reference: SNOMEDCT_US_2020_03_01:61493004
has cross-reference: SNOMEDCT_US_2020_03_01:6381009
has cross-reference: SNOMEDCT_US_2020_03_01:68979007
has cross-reference: UMLS_CUI:C0018852
has cross-reference: UMLS_CUI:C0018854
has cross-reference: UMLS_CUI:C0242310
has_obo_namespace: disease_ontology
id: DOID:0060125
in subset: NCIthesaurus

alpha chain disease
type: Class
subclass of: heavy chain disease
textual definition: A heavy chain disease that results from an overproduction of alpha antibodies (IgA).
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T11:23:09Z
alternative_term: Seligmann's disease
has_obo_namespace: disease_ontology
id: DOID:0060126

gamma heavy chain disease
type: Class
subclass of: heavy chain disease
textual definition: A heavy chain disease that results from an overproduction of gamma antibody (IgG).
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T11:23:09Z
has cross-reference: GARD:10346
alternative_term: Franklin's disease
has_obo_namespace: disease_ontology
id: DOID:0060127

mu chain disease
type: Class
subclass of: heavy chain disease
textual definition: A heavy chain disease that results from an overproduction of mu antibody (IgM).
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T11:23:09Z
has_obo_namespace: disease_ontology
id: DOID:0060128

alexithymia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a deficiency in understanding, processing, or describing emotions.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060131

amusia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to recognize musical notes, rhythms, and intervals.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
alternative_term: receptive amusia
has_obo_namespace: disease_ontology
id: DOID:0060132

anosognosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to gain feedback about one's own condition or impairments.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060133

apperceptive agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to distinguish visual shapes.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060134

apraxia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has cross-reference: GARD:5838
has cross-reference: ICD10CM:R48.2
has cross-reference: SNOMEDCT_US_2019_09_01:68345001
has_obo_namespace: disease_ontology
id: DOID:0060135

associative agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to recognize visual scenes or classes of objects but retain the abilty to describe them.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060136

auditory agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to distinguishing environmental and non-verbal auditory cues including difficulty distinguishing speech from non-speech sounds even though hearing is usually normal.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060137

cortical deafness
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060140

finger agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to distinguish the fingers on the hand.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060141

form agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060142

pain agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to perceive and process pain.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
alternative_term: analgesia
has_obo_namespace: disease_ontology
id: DOID:0060145

simultanagnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to recgonize a whole image or scene while retianing the ability to recognize objects or details in their visual field one at a time.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has cross-reference: GARD:11943
has_obo_namespace: disease_ontology
id: DOID:0060148

astereognosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is the loss of the ability to recognize objects by touch based on its texture, size and weight.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
alternative_term: somatosensory agnosia
has_obo_namespace: disease_ontology
id: DOID:0060150

tactile agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to recognize or identify objects by touch alone.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060151

verbal auditory agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to recognising spoken words as semantically meaningful.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has_obo_namespace: disease_ontology
id: DOID:0060154

visual agnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that is a loss of the ability to visually recognize objects.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-22T12:04:56Z
has cross-reference: MESH:C531604
has cross-reference: UMLS_CUI:C2930796
has_obo_namespace: disease_ontology
id: DOID:0060155

acquired metabolic disease
type: Class
subclass of: disease of metabolism
textual definition: A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-24T02:53:03Z
has_obo_namespace: disease_ontology
id: DOID:0060158
in subset: DO MGI slim

organic acidemia
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-26T11:17:14Z
has cross-reference: GARD:9433
alternative_term: organic acid metabolism disorder
alternative_term: organic aciduria
has_obo_namespace: disease_ontology
id: DOID:0060159

childhood spinal muscular atrophy
type: Class
subclass of: spinal muscular atrophy
textual definition: A spinal muscular atrophy that is associated with the survival of motor neuron protein in childhood.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-29T01:15:14Z
has cross-reference: GARD:7674
has cross-reference: MESH:D014897
has cross-reference: NCI:C85076
has cross-reference: ORDO:70
has cross-reference: UMLS_CUI:C0700595
alternative_term: spinal muscular atrophies of childhood
alternative_term: survival motor neuron spinal muscular atrophy
has_obo_namespace: disease_ontology
id: DOID:0060160
in subset: DO FlyBase slim
in subset: NCIthesaurus

Kennedy's disease
type: Class
subclass of: X-linked recessive disease
subclass of: spinal muscular atrophy
textual definition: A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine) in exon 1 of AR gene encoding the androgen receptor.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-29T01:31:03Z
has cross-reference: GARD:6818
has cross-reference: MESH:D055534
has cross-reference: NCI:C85233
has cross-reference: OMIM:313200
has cross-reference: SNOMEDCT_US_2020_03_01:230253001
has cross-reference: UMLS_CUI:C1839259
alternative_term: Kennedy disease
alternative_term: SBMA
alternative_term: Spinobulbar Muscular Atrophy
alternative_term: X-Linked Bulbo-Spinal Atrophy
alternative_term: X-linked Spinal and Bulbar Muscular Atrophy
alternative_term: spinal bulbar muscular atrophy
has_obo_namespace: disease_ontology
id: DOID:0060161
in subset: DO FlyBase slim
in subset: NCIthesaurus

dentatorubral-pallidoluysian atrophy
type: Class
subclass of: autosomal dominant cerebellar ataxia
textual definition: An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-08-29T01:41:48Z
has cross-reference: GARD:5643
has cross-reference: MESH:D020191
has cross-reference: NCI:C122653
has cross-reference: OMIM:125370
has cross-reference: SNOMEDCT_US_2020_03_01:702422004
has cross-reference: UMLS_CUI:C0751781
alternative_term: DRPLA
alternative_term: Haw River Syndrome
alternative_term: Naito-Oyanagi disease
has_obo_namespace: disease_ontology
id: DOID:0060162
in subset: DO FlyBase slim
in subset: NCIthesaurus

body dysmorphic disorder
type: Class
subclass of: somatoform disorder
textual definition: A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image).
imported from: doid.owl
created_by: lschriml
creation_date: 2011-09-07T01:38:34Z
alternative_term: body dysmorphia
alternative_term: dysmorphic syndrome
alternative_term: dysmorphophobia
has_obo_namespace: disease_ontology
id: DOID:0060163

pain disorder
type: Class
subclass of: somatoform disorder
textual definition: A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-09-07T01:42:46Z
has_obo_namespace: disease_ontology
id: DOID:0060164

Kleine-Levin syndrome
type: Class
subclass of: DOID 8619
textual definition: A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-09-07T02:46:02Z
has cross-reference: MESH:D017593
has cross-reference: OMIM:148840
has_obo_namespace: disease_ontology
id: DOID:0060165

histidinemia
type: Class
subclass of: DOID 9265
textual definition: A histidine metabolism disease characterized by a deficiency of the enzyme histidase.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-09-20T12:47:05Z
has cross-reference: GARD:6661
has cross-reference: MESH:C538320
has cross-reference: OMIM:235800
alternative_term: histidinuria
has_obo_namespace: disease_ontology
id: DOID:0060168

benign familial infantile epilepsy
type: Class
subclass of: infancy electroclinical syndrome
textual definition: An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-10-28T02:55:02Z
has cross-reference: GARD:1518
has cross-reference: GARD:857
has cross-reference: OMIM:601764
has cross-reference: OMIM:605751
has cross-reference: OMIM:607745
has cross-reference: OMIM:612627
has cross-reference: ORDO:306
alternative_term: BFIC
alternative_term: BFIE
alternative_term: benign familial infantile convulsion
alternative_term: benign familial infantile seizures
has_obo_namespace: disease_ontology
id: DOID:0060169
in subset: DO rare slim
comment: Xref MGI.

juvenile absence epilepsy
type: Class
subclass of: adolescence-adult electroclinical syndrome
textual definition: An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-11-08T10:42:18Z
has_obo_namespace: disease_ontology
id: DOID:0060172
comment: JA:Epilepsy Genetics Kiel

Timothy syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form that has_material_basis_in mutations in a transcript variant of CACNA1C on chromosome 12p13.33.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-11-08T12:52:33Z
has_alternative_id: DOID:0110649
has cross-reference: ICD10CM:G72.3
has cross-reference: MESH:C536962
has cross-reference: OMIM:601005
has cross-reference: ORDO:65283
has cross-reference: ORDO:768
has_obo_namespace: disease_ontology
id: DOID:0060173

succinic semialdehyde dehydrogenase deficiency
type: Class
subclass of: gamma-amino butyric acid metabolism disorder
textual definition: A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-11-08T02:02:12Z
has cross-reference: MESH:C535803
has cross-reference: OMIM:271980
alternative_term: 4-hydroxybutyric aciduria
alternative_term: SSADH
alternative_term: gamma-hydroxybutyric aciduria
has_obo_namespace: disease_ontology
id: DOID:0060175

gamma-amino butyric acid metabolism disorder
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-11-08T02:02:12Z
has_obo_namespace: disease_ontology
id: DOID:0060176

homocarnosinosis
type: Class
subclass of: gamma-amino butyric acid metabolism disorder
subclass of: DOID 936
textual definition: A gamma-amino butyric acid metabolism disorder that is characterized by an excess of homocarnosine in the brain and has_material_basis_in a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-11-08T02:02:12Z
has cross-reference: GARD:2730
has cross-reference: MESH:C535328
has_obo_namespace: disease_ontology
id: DOID:0060177

colitis
type: Class
subclass of: inflammatory bowel disease
textual definition: An inflammatory bowel disease that involves inflammation located_in colon.
imported from: doid.owl
created_by: emitraka
creation_date: 2014-09-12T14:31:45Z
has cross-reference: EFO:0003872
has cross-reference: ICD10CM:K52.9
has cross-reference: MESH:D003092
has cross-reference: NCI:C26723
has cross-reference: SNOMEDCT_US_2020_03_01:64226004
has cross-reference: UMLS_CUI:C0009319
has_obo_namespace: disease_ontology
id: DOID:0060180
in subset: NCIthesaurus

physical urticaria
type: Class
subclass of: urticaria
textual definition: An urticaria induced by external physical influences.
imported from: doid.owl
created_by: emitraka
creation_date: 2014-11-21T15:51:38Z
has_obo_namespace: disease_ontology
id: DOID:0060220
comment: WD correction.

atrial fibrillation
type: Class
subclass of: heart conduction disease
textual definition: A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.
imported from: doid.owl
created_by: emitraka
creation_date: 2015-01-16T14:55:21Z
has cross-reference: ICD9CM:427.31
has cross-reference: MESH:D001281
has cross-reference: NCI:C50466
has cross-reference: SNOMEDCT_US_2020_03_01:266306001
has cross-reference: UMLS_CUI:C0004238
alternative_term: A-fib
has_obo_namespace: disease_ontology
id: DOID:0060224
in subset: NCIthesaurus

gallbladder disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the gallbladder.
imported from: doid.owl
created_by: emitraka
creation_date: 2015-02-02T15:48:08Z
has_alternative_id: DOID:0000000
has cross-reference: ICD10CM:K82.9
has cross-reference: ICD9CM:575.9
has cross-reference: MESH:D005705
has cross-reference: NCI:C34631
has cross-reference: OMIM:609918
has cross-reference: OMIM:609919
has cross-reference: OMIM:611465
has cross-reference: SNOMEDCT_US_2020_03_01:155807008
has cross-reference: UMLS_CUI:C0016977
has_obo_namespace: disease_ontology
id: DOID:0060262
in subset: NCIthesaurus
comment: Xref MGI.

autosomal dominant non-syndromic intellectual disability
type: Class
subclass of: autosomal dominant disease
subclass of: non-syndromic intellectual disability
textual definition: A non-syndromic intellectual disability characterized by an autosomal dominant inheritance pattern.
imported from: doid.owl
created_by: emitraka
creation_date: 2015-02-10T16:47:55Z
has cross-reference: GARD:12107
has cross-reference: OMIM:PS156200
has cross-reference: ORDO:178469
alternative_term: autosomal dominant mental retardation
alternative_term: autosomal dominant non-syndromic mental retardation
has_obo_namespace: disease_ontology
id: DOID:0060307
in subset: DO rare slim
comment: NT MGI.

syndromic X-linked intellectual disability
type: Class
subclass of: X-linked monogenic disease
subclass of: syndromic intellectual disability
textual definition: A syndromic intellectual characterized by an X-linked inheritance pattern.
imported from: doid.owl
created_by: emitraka
creation_date: 2015-02-11T16:14:46Z
has cross-reference: OMIM:PS309510
alternative_term: syndromic X-linked mental retardation
has_obo_namespace: disease_ontology
id: DOID:0060309
comment: NT MGI.

ciliopathy
type: Class
subclass of: monogenic disease
subclass of: syndrome
textual definition: A syndrome associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia.
imported from: doid.owl
created_by: emitraka
creation_date: 2015-05-21T10:41:29Z
has_obo_namespace: disease_ontology
id: DOID:0060340

chromosomal deletion syndrome
type: Class
subclass of: chromosomal disease
textual definition: A chromosomal disease that has_material_basis_in partial deletion of chromosomes.
imported from: doid.owl
created_by: elvira
creation_date: 2015-09-28T15:48:41Z
has_obo_namespace: disease_ontology
id: DOID:0060388

chromosomal duplication syndrome
type: Class
subclass of: chromosomal disease
textual definition: A chromosomal disease that has_material_basis_in extra copies of a chromosomal region.
imported from: doid.owl
created_by: elvira
creation_date: 2015-10-02T15:19:23Z
has_obo_namespace: disease_ontology
id: DOID:0060429

epithelial-stromal TGFBI dystrophy
type: Class
subclass of: corneal dystrophy
textual definition: A corneal dystrophy that is characterized by abnormal deposition of proteins in the cornea and is caused by mutations in TGFBI gene of chromosome 5q.
imported from: doid.owl
created_by: elvira
creation_date: 2015-10-16T16:39:25Z
has_obo_namespace: disease_ontology
id: DOID:0060441

stromal dystrophy
type: Class
subclass of: corneal dystrophy
textual definition: A corneal dystrophy that affects the corneal stroma.
imported from: doid.owl
created_by: elvira
creation_date: 2015-10-16T16:39:25Z
has_obo_namespace: disease_ontology
id: DOID:0060442

corneal endothelial dystrophy
type: Class
subclass of: corneal dystrophy
textual definition: A corneal dystrophy that affects the corneal endothelium and/or the descemet membrane.
imported from: doid.owl
created_by: elvira
creation_date: 2015-10-16T16:39:25Z
alternative_term: endothelial dystrophy
has_obo_namespace: disease_ontology
id: DOID:0060443

respiratory allergy
type: Class
subclass of: allergic disease
textual definition: An allergic disease that is located_in the respiratory tract.
imported from: doid.owl
alternative_term: airway allergy
has_obo_namespace: disease_ontology
id: DOID:0060496
in subset: DO IEDB slim

gastrointestinal allergy
type: Class
subclass of: allergic disease
textual definition: An allergic disease that is located_in the gastrointestinal tract.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060502
in subset: DO IEDB slim

fruit allergy
type: Class
subclass of: food allergy
textual definition: A food allergy triggered by a plant fruit product.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060503
in subset: DO IEDB slim

spinal disease
type: Class
subclass of: bone disease
textual definition: A bone disease that is located_in the spine.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060564

abdominal obesity-metabolic syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease.
imported from: doid.owl
has cross-reference: GARD:9226
has cross-reference: OMIM:PS605552
has_obo_namespace: disease_ontology
id: DOID:0060611

autosomal recessive congenital ichthyosis
type: Class
subclass of: autosomal recessive disease
subclass of: physical disorder
subclass of: ichthyosis
textual definition: An ichthyosis that is characterized by autosomal recessive inheritance and abnormal skin scaling over the whole body due to a defect in keratinization.
imported from: doid.owl
has_alternative_id: DOID:1699
has cross-reference: ICD10CM:Q80.2
has cross-reference: MESH:D017490
has cross-reference: NCI:C84805
has cross-reference: OMIM:PS242300
has cross-reference: ORDO:281097
has cross-reference: SNOMEDCT_US_2020_03_01:12215009
has cross-reference: UMLS_CUI:C0079154
alternative_term: ARCI
alternative_term: lamellar ichthyosis
alternative_term: non bullous congenital ichthyosiform erythroderma
has_obo_namespace: disease_ontology
id: DOID:0060655
in subset: NCIthesaurus

anencephaly
type: Class
subclass of: congenital nervous system abnormality
textual definition: A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp.
imported from: doid.owl
has cross-reference: GARD:5808
has cross-reference: ICD10CM:Q00.0
has cross-reference: OMIM:206500
has cross-reference: ORDO:1048
has_obo_namespace: disease_ontology
id: DOID:0060668
in subset: DO rare slim

hypomyelinating leukodystrophy
type: Class
subclass of: leukodystrophy
textual definition: A leukodystrophy characterized by T2 hyperintensity and T1 iso- or hyperintensity of affected white matter in the central nervous system.
imported from: doid.owl
has cross-reference: OMIM:PS312080
alternative_term: HLD
has_obo_namespace: disease_ontology
id: DOID:0060786

hypotonia-cystinuria syndrome
type: Class
subclass of: chromosomal deletion syndrome
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in homozygous deletion on chromosome 2p21 that disrupts the SLC3A1 and PREPL genes. The deletion ranges in size from 23.8 to 75.5 kb. Itis characterized_by neonatal and infantile hypotonia and failure to thrive, cystinuria type 1 and nephrolithiasis, growth retardation due to growth hormone deficiency, and minor facial dysmorphism.
imported from: doid.owl
has cross-reference: ICD10CM:E72.0
has cross-reference: OMIM:606407
has cross-reference: ORDO:163690
alternative_term: cystinuria with mitochondrial disease
has_obo_namespace: disease_ontology
id: DOID:0060858

salmonellosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease caused by the bacteria of the genus Salmonella. It has sypmtoms diarrhea, fever, vomiting, and abdominal cramps 12 to 72 hours after infection. In most cases, the illness lasts four to seven days, and most people recover without treatment.
imported from: doid.owl
has cross-reference: ICD10CM:A02.0
has cross-reference: ICD9CM:003.0
alternative_term: Salmonella infection
has_obo_namespace: disease_ontology
id: DOID:0060859

thrombosis
type: Class
subclass of: vascular disease
textual definition: A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
imported from: doid.owl
has cross-reference: MESH:D013927
has_obo_namespace: disease_ontology
id: DOID:0060903

legume allergy
type: Class
subclass of: fruit allergy
textual definition: A fruit allergy triggered by Fabaceae (legume) plant fruit or seed food product.
imported from: doid.owl
alternative_term: Fabaceae allergy
has_obo_namespace: disease_ontology
id: DOID:0060904

blastoma
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from precursor cells called blast cells.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0070003

myeloid neoplasm
type: Class
subclass of: bone marrow cancer
textual definition: A bone marrow cancer that is formed of any one of the bone marrow cells belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages.
imported from: doid.owl
alternative_term: myeloma
has_obo_namespace: disease_ontology
id: DOID:0070004

absence epilepsy
type: Class
subclass of: electroclinical syndrome
textual definition: An electroclinical syndrome characterized by the occurrence of generalized onset seizures that cause lapses in awareness, begin and end abruptly, typically last only a few seconds and are associated with abnormal spike-wave discharges as seen by electroencephalogram.
imported from: doid.owl
has cross-reference: MESH:D004832
has_obo_namespace: disease_ontology
id: DOID:0070309

thiamine deficiency disease
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by low levels of thiamine.
imported from: doid.owl
has cross-reference: NCI:C34418
has cross-reference: SNOMEDCT_US_2020_03_01:399357009
has_obo_namespace: disease_ontology
id: DOID:0070313
in subset: NCIthesaurus

mitochondrial DNA depletion syndrome
type: Class
subclass of: mitochondrial metabolism disease
textual definition: A mitochondrial metabolism disease that is characterized by significant reduction in mitochondrial DNA in affected tissues, resulting in impaired mtDNA-encoded protein synthesis and energy production in the affected tissues and organs.
imported from: doid.owl
has cross-reference: GARD:13643
has cross-reference: OMIM:PS603041
has cross-reference: ORDO:35698
alternative_term: mtDNA depletion syndrome
has_obo_namespace: disease_ontology
id: DOID:0070329

muscular disease
type: Class
subclass of: musculoskeletal system disease
textual definition: A musculoskeletal system disease that affects the muscles.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080000

bone disease
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.
imported from: doid.owl
has_alternative_id: DOID:1290
has cross-reference: ICD10CM:M89.9
has cross-reference: MESH:D001847
has cross-reference: SNOMEDCT_US_2020_03_01:76069003
has cross-reference: UMLS_CUI:C0005940
has_obo_namespace: disease_ontology
has_related_synonym: skeletal disease
id: DOID:0080001

bone remodeling disease
type: Class
subclass of: bone disease
textual definition: A bone disease that results_in formation or resorption abnormalities located_in bone.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080005

bone development disease
type: Class
subclass of: bone disease
textual definition: A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080006

bone deterioration disease
type: Class
subclass of: bone structure disease
textual definition: A bone structure disease that results_in change or damage of structure located_in bone.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080007

ischemic bone disease
type: Class
subclass of: bone disease
textual definition: A bone disease that results_in an interruption of blood supply located_in bone.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080008

X-linked dominant disease
type: Class
subclass of: X-linked monogenic disease
textual definition: A X-linked monogenic disease that has_material_basis_in dominant inheritance.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080009

bone structure disease
type: Class
subclass of: spinal disease
textual definition: A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080010

bone resorption disease
type: Class
subclass of: bone remodeling disease
textual definition: A bone remodeling disease that results in an abnormal decrease of bone density or mass.
imported from: doid.owl
has cross-reference: MESH:D001862
has_obo_namespace: disease_ontology
id: DOID:0080011

X-linked recessive disease
type: Class
subclass of: X-linked monogenic disease
textual definition: A X-linked monogenic disease that has_material_basis_in recessive inheritance.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080012

chromosomal disease
type: Class
subclass of: genetic disease
textual definition: A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080014
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

physical disorder
type: Class
subclass of: disease
textual definition: A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.
imported from: doid.owl
alternative_term: congenital disorder
has_obo_namespace: disease_ontology
id: DOID:0080015
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

spina bifida
type: Class
subclass of: neural tube defect
textual definition: A neural tube defect that is characterized by incomplete closing of the spine and membranes around the spinal cord during early development.
imported from: doid.owl
has cross-reference: GARD:7673
has cross-reference: ICD10CM:Q05
has cross-reference: ICD9CM:741
has cross-reference: MESH:D016135
has cross-reference: NCI:C101214
has cross-reference: SNOMEDCT_US_2020_03_01:156888006
has cross-reference: UMLS_CUI:C0080178
has_obo_namespace: disease_ontology
id: DOID:0080016

metaphyseal dysplasia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that is characterized by abnormally broad ends of the arm and leg long bones resembling a boat oar or paddle due to enlargement of the spongy inner layer of bone.
imported from: doid.owl
has cross-reference: OMIM:215050
alternative_term: Bakwin-Krida syndrome
alternative_term: Pyle's disease
alternative_term: Pyle-Cohn syndrome
has_obo_namespace: disease_ontology
id: DOID:0080019

spondyloepimetaphyseal dysplasia
type: Class
subclass of: spinal disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that results_in abnormalities of bone growth located_in vertebral column, located_in epiphysis, located_in metaphysis.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080027

fibrous dysplasia
type: Class
subclass of: bone remodeling disease
textual definition: A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue.
imported from: doid.owl
has cross-reference: GARD:6444
has_obo_namespace: disease_ontology
id: DOID:0080031

craniometaphyseal dysplasia
type: Class
subclass of: osteosclerosis
textual definition: An osteosclerosis that is characterized by hyperostosis and sclerosis of the craniofacial bones associated with abnormal modeling of the metaphyses.
imported from: doid.owl
has cross-reference: OMIM:PS123000
has cross-reference: ORDO:1522
has_obo_namespace: disease_ontology
id: DOID:0080033
in subset: DO rare slim
comment: Xref MGI.

SOST-related sclerosing bone dysplasia
type: Class
subclass of: autosomal recessive disease
subclass of: hyperostosis
textual definition: A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.
imported from: doid.owl
has_alternative_id: DOID:0080035
has cross-reference: OMIM:239100
has cross-reference: ORDO:3152
alternative_term: van Buchem disease
has_obo_namespace: disease_ontology
id: DOID:0080036

pycnodysostosis
type: Class
subclass of: autosomal recessive disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.
imported from: doid.owl
has cross-reference: GARD:4611
has cross-reference: MESH:D058631
has cross-reference: OMIM:265800
has cross-reference: ORDO:763
has_obo_namespace: disease_ontology
id: DOID:0080038

hypochondroplasia
type: Class
subclass of: autosomal dominant disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism.
imported from: doid.owl
has cross-reference: GARD:6724
has cross-reference: ICD10CM:Q77.4
has cross-reference: MESH:C562937
has cross-reference: NCI:C118697
has cross-reference: OMIM:146000
has cross-reference: ORDO:429
has cross-reference: SNOMEDCT_US_2020_03_01:205468002
has cross-reference: UMLS_CUI:C0410529
has_obo_namespace: disease_ontology
id: DOID:0080041

achondrogenesis
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.
imported from: doid.owl
has cross-reference: GARD:2882
has cross-reference: OMIM:PS200600
has_obo_namespace: disease_ontology
id: DOID:0080043

Kniest dysplasia
type: Class
subclass of: autosomal dominant disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.
imported from: doid.owl
has cross-reference: GARD:6841
has cross-reference: MESH:C537207
has cross-reference: OMIM:156550
has_obo_namespace: disease_ontology
id: DOID:0080045

Stickler syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems.
imported from: doid.owl
has cross-reference: GARD:10782
has cross-reference: OMIM:PS108300
has cross-reference: ORDO:828
has_obo_namespace: disease_ontology
id: DOID:0080046
comment: OMIM mapping confirmed by DO. [SN].

pseudoachondroplasia
type: Class
subclass of: autosomal dominant disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism.
imported from: doid.owl
has_alternative_id: DOID:14800
has cross-reference: GARD:4540
has cross-reference: MESH:C535819
has cross-reference: OMIM:177170
alternative_term: PSEUDOACHONDROPLASIA
alternative_term: SPONDYLOEPIPHYSEAL DYSPLASIA, PSEUDOACHONDROPLASTIC
alternative_term: pseudoachondroplastic dysplasia
has_obo_namespace: disease_ontology
id: DOID:0080047
comment: OMIM mapping confirmed by DO. [SN].

acromesomelic dysplasia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb dwarfism.
imported from: doid.owl
has cross-reference: GARD:6
has cross-reference: ORDO:93437
has_obo_namespace: disease_ontology
id: DOID:0080049

intestinal pseudo-obstruction
type: Class
subclass of: colonic disease
textual definition: A colonic disease that is characterized by bowel obstruction resulting from impairment of the muscle contractions that move food through the digestive tract.
imported from: doid.owl
created_by: lschriml
creation_date: 2015-10-19T14:28:30Z
has_alternative_id: DOID:3878
has cross-reference: GARD:12744
has cross-reference: GARD:6789
has cross-reference: MESH:D007418
has cross-reference: NCI:C34733
has cross-reference: ORDO:2978
has cross-reference: SNOMEDCT_US_2020_03_01:715201005
has cross-reference: UMLS_CUI:C0021847
alternative_term: Chronic intestinal pseudo-obstruction
alternative_term: neuronal intestinal dysplasia
has_obo_namespace: disease_ontology
id: DOID:0080072
in subset: NCIthesaurus

neural tube defect
type: Class
subclass of: physical disorder
textual definition: A physical disorder characterized by incomplete closure of the neural tube.
imported from: doid.owl
created_by: lschriml
creation_date: 2015-10-19T14:41:42Z
has cross-reference: GARD:4016
has cross-reference: OMIM:301410
has cross-reference: OMIM:601634
has_obo_namespace: disease_ontology
id: DOID:0080074

Alpers-Huttenlocher syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: mitochondrial DNA depletion syndrome
textual definition: A mitochondrial DNA depletion syndrome that is characterized by a clinical triad of psychomotor retardation, intractable epilepsy, and liver failure in infants and young children, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the nuclear gene encoding mitochondrial DNA polymerase gamma on chromosome 15q26.
imported from: doid.owl
has_alternative_id: DOID:1442
has cross-reference: GARD:5783
has cross-reference: ICD10CM:G31.81
has cross-reference: MESH:D002549
has cross-reference: NCI:C35257
has cross-reference: OMIM:203700
has cross-reference: ORDO:726
has cross-reference: SNOMEDCT_US_2020_03_01:20415001
has cross-reference: UMLS_CUI:C0205710
alternative_term: Alper's syndrome
alternative_term: Alpers disease
alternative_term: Alpers progressive infantile poliodystrophy
alternative_term: Alpers syndrome
alternative_term: Alpers' disease or gray-matter degeneration
alternative_term: Diffuse Cerebral Sclerosis of Schilder
alternative_term: mitochondrial DNA depletion syndrome 4a
alternative_term: progressive sclerosing poliodystrophy
has_obo_namespace: disease_ontology
id: DOID:0080122
in subset: DO rare slim
in subset: NCIthesaurus

mitochondrial DNA depletion syndrome 7
type: Class
subclass of: autosomal recessive disease
subclass of: mitochondrial DNA depletion syndrome
textual definition: A mitochondrial DNA depletion syndrome that is characterized by progressive ataxia, hypotonia, hyporeflexia, athetosis and sensory impairment and has_material_basis_in autosomal recessive homozygous or compound heterozygous mutation in the C10ORF2 gene, which encodes the twinkle and twinky proteins, on chromosome 10q24.
imported from: doid.owl
has_alternative_id: DOID:0050556
has cross-reference: GARD:4062
has cross-reference: MESH:C535523
has cross-reference: OMIM:271245
alternative_term: OHAHA SYNDROME
alternative_term: infantile onset spinocerebellar ataxia
has_obo_namespace: disease_ontology
id: DOID:0080126

lysosomal and lipase deficiency
type: Class
subclass of: DOID 9455
textual definition: A lipid storage disease characterized by lysosomal and lipase deficiency.
imported from: doid.owl
has cross-reference: OMIM:278000
has_obo_namespace: disease_ontology
id: DOID:0080217

peripheral nervous system benign neoplasm
type: Class
subclass of: central nervous system benign neoplasm
textual definition: A central nervous system benign neoplasm the is located_in the peripheral nervous system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080320

autonomic nervous system benign neoplasm
type: Class
subclass of: peripheral nervous system benign neoplasm
textual definition: A peripheral nervous system benign neoplasm that is located_in the autonomic nervous system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080321

polycystic kidney disease
type: Class
subclass of: cystic kidney disease
textual definition: A cystic kidney disease that is characterized by the growth of fluid-filled cysts in the kidneys that reduces kidney function and may lead to kidney failure.
imported from: doid.owl
has cross-reference: OMIM:PS173900
has_obo_namespace: disease_ontology
id: DOID:0080322

hepatobiliary system cancer
type: Class
subclass of: gastrointestinal system cancer
textual definition: A gastrointestinal system cancer that is located_in the hepatobiliary system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080355

malignant adenoma
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures, representing an early form of colorectal cancer.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080364

epididymis disease
type: Class
subclass of: male reproductive system disease
textual definition: A male reproductive system disease that is located_in the epididymis.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080373

peroxisomal biogenesis disorder
type: Class
subclass of: DOID 906
textual definition: A peroxisomal biogenesis disorder that has_material_basis_in defects in PEX genes.
imported from: doid.owl
has_alternative_id: DOID:0080378
has cross-reference: OMIM:PS214100
has_obo_namespace: disease_ontology
id: DOID:0080377

Dravet syndrome
type: Class
subclass of: early infantile epileptic encephalopathy
textual definition: An early infantile epileptic encephalopathy that has_material_basis_in heterozygous mutation in the SCN1A gene on chromosome 2q24.
imported from: doid.owl
has_alternative_id: DOID:0060171
has cross-reference: GARD:10430
has cross-reference: OMIM:607208
has cross-reference: ORDO:33069
alternative_term: early infantile epileptic encephalopathy 6
has_obo_namespace: disease_ontology
id: DOID:0080422
in subset: DO FlyBase slim

mucolipidosis
type: Class
subclass of: DOID 9455
textual definition: A lipid storage disease that is characterized by increased storage of carbohydrates and lipids.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080488

thyroid gland adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: thyroid gland carcinoma
textual definition: A thyroid gland carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C27380
has_obo_namespace: disease_ontology
id: DOID:0080524
in subset: DO cancer slim
in subset: NCIthesaurus

differentiated thyroid gland carcinoma
type: Class
subclass of: thyroid gland adenocarcinoma
textual definition: A thyroid gland adenocarcinoma characterized by extensive evidence of follicular cell differentiation.
imported from: doid.owl
has cross-reference: NCI:C7153
has_obo_namespace: disease_ontology
id: DOID:0080525
in subset: DO cancer slim
in subset: NCIthesaurus

hyper IgM syndrome
type: Class
subclass of: hyperimmunoglobulin syndrome
textual definition: A hyperimmunoglobin syndrome that is characterized by an immune system that fails to produce normal levels of the antibodies IgA, IgG and IgE but can produce normal or elevated levels of IgM.
imported from: doid.owl
has cross-reference: NCI:C3990
has cross-reference: OMIM:PS308230
alternative_term: immunodeficiency with hyper-IgM
has_obo_namespace: disease_ontology
id: DOID:0080544

hyper IgE syndrome
type: Class
subclass of: hyperimmunoglobulin syndrome
textual definition: A hyperimmunoglobulin syndrome that is characterized by eczema, distinct facial features, a tendency to experience bone fractures and recurrent bacterial infections of the skin and lungs.
imported from: doid.owl
has cross-reference: GARD:10956
has cross-reference: OMIM:PS147060
alternative_term: hyper immunoglobulin E syndrome
has_obo_namespace: disease_ontology
id: DOID:0080545

Coronavirus infectious disease
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that has_material_basis_in Coronavirus.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080599

germ cell benign neoplasm
type: Class
subclass of: cell type benign neoplasm
textual definition: A benign neoplasm that derives_from germ cells.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080601

benign teratoma
type: Class
subclass of: germ cell benign neoplasm
textual definition: A germ cell benign neoplasm that derives_from mature tissue elements or a limited amount of immature tissue elements.
imported from: doid.owl
has cross-reference: NCI:C67107
has_obo_namespace: disease_ontology
id: DOID:0080602

nephroma
type: Class
subclass of: kidney cortex disease
subclass of: kidney benign neoplasm
textual definition: A kidney benign neoplasm that is located_in the kidney cortex.
imported from: doid.owl
alternative_term: benign nephroma
has_obo_namespace: disease_ontology
id: DOID:0080615

kidney cortex disease
type: Class
subclass of: kidney disease
textual definition: A kidney disease that is located_in the kidney cortex.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080616

auditory system benign neoplasm
type: Class
subclass of: sensory organ benign neoplasm
subclass of: auditory system disease
textual definition: A sensory system benign neoplasm that is located in the auditory system.
imported from: doid.owl
has cross-reference: NCI:C8417
has_obo_namespace: disease_ontology
id: DOID:0080619

B-lymphoblastic leukemia/lymphoma
type: Class
subclass of: B-cell acute lymphoblastic leukemia
textual definition: A B-cell acute lymphoblastic leukemia that is characterized by the presence of too many B-cell lymphoblasts in the blood and bone marrow.
imported from: doid.owl
has_alternative_id: DOID:7061
has cross-reference: NCI:C8936
has cross-reference: UMLS_CUI:C0862030
alternative_term: B-ALL
alternative_term: precursor B lymphoblastic lymphoma/leukemia
has_obo_namespace: disease_ontology
id: DOID:0080630
in subset: DO cancer slim
in subset: NCIthesaurus

B-cell acute lymphoblastic leukemia
type: Class
subclass of: lymphoma
subclass of: DOID 9952
textual definition: An acute lymphocytic leukemia characterized by too many B-cell lymphoblasts (immature white blood cells) in the bone marrow and blood.
imported from: doid.owl
has cross-reference: NCI:C8644
alternative_term: B acute lymphoblastic leukemia
alternative_term: B-cell acute lymphocytic leukemia
has_obo_namespace: disease_ontology
id: DOID:0080638
in subset: DO cancer slim

bone sarcoma
type: Class
subclass of: sarcoma
subclass of: bone cancer
textual definition: A bone cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080639

RASopathy
type: Class
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in mutations in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction.
imported from: doid.owl
alternative_term: RAS/mitogen-activated protein kinase syndrome
has_obo_namespace: disease_ontology
id: DOID:0080690

acute asthma
type: Class
subclass of: asthma
textual definition: An asthma that is characterized by severe and sudden onset of increasing wheezing, airways closing, smooth muscle contraction, mucus plugging and lower airway edema that may be reversible upon treatment.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080810

low-grade glioma
type: Class
subclass of: malignant glioma
textual definition: A malignant glioma that originate from two types of glial cells, astrocytes and oligodendrocytes.
imported from: doid.owl
has cross-reference: NCI:C132067
has_obo_namespace: disease_ontology
id: DOID:0080829
in subset: DO cancer slim

pediatric low-grade glioma
type: Class
subclass of: low-grade glioma
textual definition: A low-grade glioma that occurs in children and encompasses tumors of astrocytic, oligodendroglial, and mixed glial-neuronal histology.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080830
in subset: DO cancer slim

hypogonadotropic hypogonadism
type: Class
subclass of: hypogonadism
textual definition: A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone.
imported from: doid.owl
has_alternative_id: DOID:7455
has cross-reference: ICD10CM:E23.0
has cross-reference: OMIM:PS147950
has cross-reference: ORDO:432
has cross-reference: ORDO:478
alternative_term: congenital idiopathic hypogonadotropic hypogonadism
alternative_term: hypogonadotropism
alternative_term: isolated congenital gonadotropin deficiency
has_obo_namespace: disease_ontology
id: DOID:0090070

neuronal ceroid lipofuscinosis 3
type: Class
subclass of: neuronal ceroid lipofuscinosis
subclass of: genetic disease
textual definition: A neuronal ceroid lipofuscinosis that is characterized by juvenile-onset of progressive dementia, seizures, and progressive visual failure and an ultrastructural pattern of lipopigment with a 'fingerprint' profile and has_material_basis_in homozygous or compound heterozygous mutation in the CLN3 gene on chromosome 16p11.
imported from: doid.owl
has_alternative_id: DOID:0050756
has cross-reference: GARD:5897
has cross-reference: ICD10CM:E75.4
has cross-reference: OMIM:204200
has cross-reference: ORDO:228346
alternative_term: Batten disease
alternative_term: CLN3
alternative_term: juvenile neuronal ceroid lipofuscinosis
has_obo_namespace: disease_ontology
id: DOID:0110731
in subset: DO FlyBase slim

neurodegeneration with brain iron accumulation
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease characterized by progressive iron accumulation in the basal ganglia and other regions of the brain, resulting in extrapyramidal movements, such as parkinsonism and dystonia.
imported from: doid.owl
has cross-reference: GARD:11899
has cross-reference: MESH:C538421
has cross-reference: OMIM:PS234200
has cross-reference: ORDO:385
has cross-reference: UMLS_CUI:C2931845
alternative_term: NBIA
has_obo_namespace: disease_ontology
id: DOID:0110734

congenital muscular dystrophy-dystroglycanopathy type A
type: Class
subclass of: muscular dystrophy-dystroglycanopathy
textual definition: A congenital muscular dystrophy-dystroglycanopathy type A characterized by cobblestone lissencephaly, muscle weakness, and brain and eye anomalies that has_material_basis_in autosomal recessive inheritance a defect in alpha-dystroglycan post-translational processing.
imported from: doid.owl
has cross-reference: OMIM:PS236670
has cross-reference: ORDO:352687
alternative_term: MDDGA
alternative_term: congenital muscular alpha-dystroglycanopathy with brain and eye anomalies
alternative_term: klissencephaly type 2 with muscular and ocular involvement
has_obo_namespace: disease_ontology
id: DOID:0111229

familial chylomicronemia syndrome
type: Class
subclass of: familial hyperlipidemia
textual definition: A familial hyperlipidemia characterized by hypertriglyceridemia and fasting chylomicronemia.
imported from: doid.owl
has cross-reference: ORDO:444490
has_obo_namespace: disease_ontology
id: DOID:0111417

Aarskog syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome characterized by facial, limbs and genital anomalies, and a disproportionate acromelic short stature.
imported from: doid.owl
has cross-reference: ORDO:915
alternative_term: Aarskog-Scott syndrome
alternative_term: faciodigitogenital syndrome
alternative_term: faciogenital dysplasia
has_obo_namespace: disease_ontology
id: DOID:0111824

trichothiodystrophy
type: Class
subclass of: syndrome
textual definition: A syndrome characterized by sparse, brittle, sulfur-deficient hair that is easily broken and in more severe cases delayed development, significant intellectual disability, and recurrent infections.
imported from: doid.owl
has cross-reference: MESH:D054463
has cross-reference: NCI:C4924
has cross-reference: ORDO:33364
has cross-reference: SNOMEDCT_US_2020_03_01:723551003
has cross-reference: UMLS_CUI:C1955934
alternative_term: TTD
has_obo_namespace: disease_ontology
id: DOID:0111866

nonphotosensitive trichothiodystrophy
type: Class
subclass of: trichothiodystrophy
textual definition: A trichothiodystrophy characterized by absence of extreme sensitivity to UV radiation.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0111867

combined immunodeficiency
type: Class
subclass of: primary immunodeficiency disease
textual definition: A primary immunodeficiency disease that involves multiple components of the immune system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0111962

intestinal infectious disease
type: Class
subclass of: intestinal disease
textual definition: An intestinal disease that involves intestinal infection that has_material_basis_in viruses, bacteria, fungi and parasites.
imported from: doid.owl
has_alternative_id: DOID:10960
has_alternative_id: DOID:12509
has_alternative_id: DOID:5270
has cross-reference: ICD10CM:A00-A09
has cross-reference: ICD9CM:001-009.99
has cross-reference: SNOMEDCT_US_2020_03_01:187266003
has cross-reference: UMLS_CUI:C0178238
alternative_term: bacterial enteritis
has_obo_namespace: disease_ontology
id: DOID:100
comment: Updating outdated UMLS CUI.

sensorineural hearing loss
type: Class
subclass of: inner ear disease
imported from: doid.owl
has_alternative_id: DOID:11053
has_alternative_id: DOID:12112
has_alternative_id: DOID:12114
has cross-reference: ICD9CM:389.1
has cross-reference: MESH:D006319
has cross-reference: NCI:C26739
has cross-reference: SNOMEDCT_US_2020_03_01:60700002
has cross-reference: UMLS_CUI:C0018784
alternative_term: High Frequency Hearing Loss
alternative_term: High frequency deafness
alternative_term: Perceptive deafness
alternative_term: Perceptive hearing loss
alternative_term: Perceptive hearing loss or deafness
alternative_term: Sensorineural Deafness
alternative_term: Sensory hearing loss
alternative_term: central hearing loss
alternative_term: high-frequency hearing loss
has_obo_namespace: disease_ontology
id: DOID:10003
in subset: DO FlyBase slim
in subset: NCIthesaurus

thyroid lymphoma
type: Class
subclass of: lymphoma
subclass of: thyroid gland cancer
imported from: doid.owl
has cross-reference: NCI:C5265
has cross-reference: UMLS_CUI:C1336753
has_obo_namespace: disease_ontology
id: DOID:10011
in subset: NCIthesaurus

multiple endocrine neoplasia type 1
type: Class
subclass of: autosomal dominant disease
subclass of: multiple endocrine neoplasia
textual definition: A multiple endocrine neoplasia that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas.
imported from: doid.owl
has cross-reference: GARD:3829
has cross-reference: ICD10CM:E31.21
has cross-reference: ICD9CM:258.01
has cross-reference: MESH:D018761
has cross-reference: NCI:C3225
has cross-reference: OMIM:131100
has cross-reference: ORDO:652
has cross-reference: SNOMEDCT_US_2020_03_01:30664006
has cross-reference: UMLS_CUI:C0025267
alternative_term: MEN type I
alternative_term: Wermer syndrome
alternative_term: Wermer's syndrome
has_obo_namespace: disease_ontology
id: DOID:10017
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

endometritis
type: Class
subclass of: endometrial disease
textual definition: An endometrial disease that is characterized by inflammation of the endometrium.
imported from: doid.owl
has cross-reference: MESH:D004716
has cross-reference: NCI:C26764
has cross-reference: SNOMEDCT_US_2020_03_01:155975003
has cross-reference: UMLS_CUI:C0014179
has_obo_namespace: disease_ontology
id: DOID:1002
in subset: NCIthesaurus

ampulla of Vater cancer
type: Class
subclass of: duodenum cancer
subclass of: bile duct cancer
imported from: doid.owl
has cross-reference: ICD10CM:C24.1
has cross-reference: ICD9CM:156.2
has cross-reference: NCI:C3536
has cross-reference: SNOMEDCT_US_2020_03_01:93668007
has cross-reference: UMLS_CUI:C0153454
alternative_term: malignant tumour of ampulla of vater
has_obo_namespace: disease_ontology
id: DOID:10020
in subset: NCIthesaurus

duodenum cancer
type: Class
subclass of: small intestine cancer
subclass of: duodenum disease
textual definition: A small intestine cancer that is located_in the beginning section of the small intestine.
imported from: doid.owl
has_alternative_id: DOID:6072
has cross-reference: ICD10CM:C17.0
has cross-reference: ICD9CM:152.0
has cross-reference: MESH:D004379
has cross-reference: NCI:C4803
has cross-reference: NCI:C9328
has cross-reference: SNOMEDCT_US_2020_03_01:254570009
has cross-reference: SNOMEDCT_US_2020_03_01:363403002
has cross-reference: UMLS_CUI:C0153426
has cross-reference: UMLS_CUI:C0541912
alternative_term: Duodenal cancer
alternative_term: cancer of duodenum
alternative_term: duodenal neoplasm
has_obo_namespace: disease_ontology
id: DOID:10021
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

migraine with aura
type: Class
subclass of: migraine
textual definition: A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon.
imported from: doid.owl
has_alternative_id: DOID:10025
has cross-reference: ICD10CM:G43.1
has cross-reference: ICD9CM:346.0
has cross-reference: MESH:D020325
has cross-reference: NCI:C117005
has cross-reference: OMIM:609179
has cross-reference: OMIM:609670
has cross-reference: SNOMEDCT_US_2020_03_01:155047002
has cross-reference: UMLS_CUI:C0154723
alternative_term: classic migraine
has_obo_namespace: disease_ontology
id: DOID:10024
in subset: NCIthesaurus
comment: Xref MGI.

tabes dorsalis
type: Class
subclass of: DOID 9988
textual definition: A tertiary neurosyphilis that results in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has symptom intense, stabbing pain in the back and legs that recurs irregularly, has symptom gait ataxia, has symptom hyperesthesia, has symptom paresthesia, has symptom loss of bladder sensation leading to urine retention, has symptom erectile dysfunction.
imported from: doid.owl
has cross-reference: GARD:8730
has cross-reference: ICD10CM:A52.11
has cross-reference: ICD9CM:094.0
has cross-reference: MESH:D013606
has cross-reference: NCI:C35057
has cross-reference: SNOMEDCT_US_2020_03_01:266134000
has cross-reference: UMLS_CUI:C0039223
alternative_term: Posterior spinal sclerosis
alternative_term: Tabes dorsalis - neurosyphilis
has_obo_namespace: disease_ontology
id: DOID:10027
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: sexually transmitted infectious disease

pelvic inflammatory disease
type: Class
subclass of: disease by infectious agent
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is characterized by an infection of the female reproductive organs.
imported from: doid.owl
has cross-reference: ICD10CM:N73.9
has cross-reference: ICD9CM:614.9
has cross-reference: MESH:D000292
has cross-reference: NCI:C3889
has cross-reference: SNOMEDCT_US_2020_03_01:266648001
has cross-reference: UMLS_CUI:C0242172
alternative_term: PID
has_obo_namespace: disease_ontology
id: DOID:1003
in subset: NCIthesaurus

cycloplegia
type: Class
subclass of: eye accommodation disease
imported from: doid.owl
has cross-reference: ICD10CM:H52.52
has cross-reference: ICD9CM:367.51
has cross-reference: SNOMEDCT_US_2020_03_01:68158006
has cross-reference: UMLS_CUI:C0235238
alternative_term: Ciliary muscle paresis
alternative_term: Cycloplegic paralysis of accommodation
alternative_term: Paresis of accommodation
has_obo_namespace: disease_ontology
id: DOID:10033

eye accommodation disease
type: Class
subclass of: eye disease
textual definition: An eye disease that is characterized by decreased ability to change the optical power of the eye to maintain a clear image.
imported from: doid.owl
has cross-reference: ICD10CM:H52.5
has cross-reference: ICD9CM:367.5
has cross-reference: SNOMEDCT_US_2020_03_01:155137002
has cross-reference: UMLS_CUI:C0152198
has_obo_namespace: disease_ontology
id: DOID:10034

dysplastic nevus syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
imported from: doid.owl
has cross-reference: MESH:D004416
has cross-reference: UMLS_CUI:C0205747
alternative_term: FAMM syndrome
alternative_term: familial atypical multiple mole-melanoma
has_obo_namespace: disease_ontology
id: DOID:10041
comment: OMIM mapping confirmed by DO. [SN].

nodular malignant melanoma
type: Class
subclass of: DOID 8923
textual definition: A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.
imported from: doid.owl
has cross-reference: GARD:9961
has cross-reference: NCI:C4225
has cross-reference: SNOMEDCT_US_2020_03_01:2142002
has cross-reference: UMLS_CUI:C0334424
alternative_term: nodular melanoma
has_obo_namespace: disease_ontology
id: DOID:10047
in subset: DO cancer slim
in subset: NCIthesaurus

endometrial disease
type: Class
subclass of: uterine disease
textual definition: A uterine disease that is located_in the endometrium.
imported from: doid.owl
has cross-reference: NCI:C3504
has cross-reference: SNOMEDCT_US_2020_03_01:418632009
has cross-reference: UMLS_CUI:C0151622
has_obo_namespace: disease_ontology
id: DOID:1005
in subset: NCIthesaurus

subglottis neoplasm
type: Class
subclass of: laryngeal benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4426
has cross-reference: SNOMEDCT_US_2020_03_01:126696001
has cross-reference: UMLS_CUI:C0345746
alternative_term: Subglottic tumor
has_obo_namespace: disease_ontology
id: DOID:10069
in subset: NCIthesaurus

hymenolepiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the bowel by Hymenolepis nana or Hymenolepis diminuta. The symptoms include diarrhea, gastrointestinal discomfort, itchy anus, poor appetite and weakness.
imported from: doid.owl
has cross-reference: GARD:2787
has cross-reference: ICD10CM:B71.0
has cross-reference: ICD9CM:123.6
has cross-reference: MESH:D006925
has cross-reference: NCI:C84768
has cross-reference: SNOMEDCT_US_2020_03_01:187153007
has cross-reference: UMLS_CUI:C0020413
alternative_term: Hymenolepis infectious disease
alternative_term: dwarf tapeworm infection
has_obo_namespace: disease_ontology
id: DOID:10074
in subset: NCIthesaurus

diphyllobothriasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.
imported from: doid.owl
has cross-reference: GARD:942
has cross-reference: ICD10CM:B70.0
has cross-reference: ICD9CM:123.4
has cross-reference: MESH:D004169
has cross-reference: NCI:C128391
has cross-reference: SNOMEDCT_US_2020_03_01:187151009
has cross-reference: UMLS_CUI:C0012561
alternative_term: DiphylloboInOwlthrium infection
alternative_term: fish tapeworm
has_obo_namespace: disease_ontology
id: DOID:10075
in subset: NCIthesaurus

cysticercosis
type: Class
subclass of: taeniasis
subclass of: muscular disease
subclass of: heart disease
subclass of: central nervous system disease
subclass of: skin disease
subclass of: eye disease
textual definition: A taeniasis that results from ingestion of eggs or larvae of the Taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. Neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions.
imported from: doid.owl
has_alternative_id: DOID:10078
has_alternative_id: DOID:14424
has cross-reference: GARD:8194
has cross-reference: ICD10CM:B69
has cross-reference: ICD9CM:123.1
has cross-reference: MESH:D003551
has cross-reference: NCI:C34520
has cross-reference: SNOMEDCT_US_2020_03_01:59051007
has cross-reference: UMLS_CUI:C0010678
alternative_term: Pork tapeworm infection
alternative_term: Tapeworm infection: intestinal taenia solum
alternative_term: Tapeworm infection: pork
alternative_term: intestinal taenia solium infection
alternative_term: neurocysticercosis
alternative_term: tenia solium infectious disease
has_obo_namespace: disease_ontology
id: DOID:10079
in subset: NCIthesaurus

sparganosis
type: Class
subclass of: urinary system disease
subclass of: inner ear disease
subclass of: breast disease
subclass of: lung disease
subclass of: DOID 883
subclass of: DOID 936
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected.
imported from: doid.owl
has cross-reference: ICD10CM:B70.1
has cross-reference: ICD9CM:123.5
has cross-reference: MESH:D013031
has cross-reference: NCI:C35030
has cross-reference: SNOMEDCT_US_2020_03_01:187152002
has cross-reference: UMLS_CUI:C0037753
alternative_term: Infection by Sparganum
alternative_term: Sparganosis
has_obo_namespace: disease_ontology
id: DOID:10080
in subset: NCIthesaurus

intracranial abscess
type: Class
subclass of: central nervous system disease
textual definition: A central nervous system disease that is located_in the skull and is characterized by a collection of pus (infected material) inside the skull.
imported from: doid.owl
has cross-reference: ICD9CM:324.0
has cross-reference: NCI:C34734
has cross-reference: SNOMEDCT_US_2020_03_01:192738001
has cross-reference: UMLS_CUI:C0021874
has_obo_namespace: disease_ontology
id: DOID:10095
in subset: NCIthesaurus

sleeping sickness
type: Class
subclass of: trypanosomiasis
textual definition: A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.
imported from: doid.owl
has cross-reference: ICD10CM:B56
has cross-reference: ICD9CM:086.5
has cross-reference: KEGG:05143
has cross-reference: MESH:D014353
has cross-reference: NCI:C84541
has cross-reference: SNOMEDCT_US_2020_03_01:27031003
has cross-reference: UMLS_CUI:C0041228
alternative_term: African sleeping sickness
alternative_term: African trypanosomiasis
has_obo_namespace: disease_ontology
id: DOID:10112
in subset: NCIthesaurus
in subset: zoonotic infectious disease

trypanosomiasis
type: Class
subclass of: parasitic protozoa infectious disease
textual definition: A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.
imported from: doid.owl
has cross-reference: ICD10CM:B57.2
has cross-reference: ICD9CM:086
has cross-reference: MESH:D014352
has cross-reference: SNOMEDCT_US_2020_03_01:266205000
has cross-reference: UMLS_CUI:C0041227
has_obo_namespace: disease_ontology
id: DOID:10113

pigmentation disease
type: Class
subclass of: skin disease
textual definition: A skin disease that is characterized by discoloration of the skin.
imported from: doid.owl
has cross-reference: ICD9CM:709.09
has cross-reference: UMLS_CUI:C0375489
has_obo_namespace: disease_ontology
id: DOID:10123

corneal disease
type: Class
subclass of: eye disease
textual definition: An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction.
imported from: doid.owl
has_alternative_id: DOID:2284
has cross-reference: ICD10CM:H18.9
has cross-reference: ICD9CM:371.9
has cross-reference: MESH:D003316
has cross-reference: NCI:C26731
has cross-reference: SNOMEDCT_US_2020_03_01:15250008
has cross-reference: UMLS_CUI:C0010034
has_obo_namespace: disease_ontology
id: DOID:10124
in subset: NCIthesaurus

keratoconus
type: Class
subclass of: corneal disease
textual definition: A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape.
imported from: doid.owl
has cross-reference: GARD:6824
has cross-reference: ICD10CM:H18.6
has cross-reference: ICD9CM:371.6
has cross-reference: MESH:D007640
has cross-reference: NCI:C26806
has cross-reference: OMIM:148300
has cross-reference: OMIM:608586
has cross-reference: OMIM:608932
has cross-reference: OMIM:609271
has cross-reference: OMIM:614622
has cross-reference: OMIM:614623
has cross-reference: OMIM:614628
has cross-reference: OMIM:614629
has cross-reference: ORDO:156071
has cross-reference: SNOMEDCT_US_2020_03_01:267733008
has cross-reference: UMLS_CUI:C0022578
alternative_term: conical cornea
has_obo_namespace: disease_ontology
id: DOID:10126
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

venous insufficiency
type: Class
subclass of: DOID 866
textual definition: A vein disease that is characterized by impaired flow of blood through the veins.
imported from: doid.owl
has cross-reference: ICD9CM:459.81
has cross-reference: MESH:D014689
has cross-reference: NCI:C127822
has cross-reference: SNOMEDCT_US_2020_03_01:20696009
has cross-reference: UMLS_CUI:C0042485
alternative_term: peripheral venous insufficiency
has_obo_namespace: disease_ontology
id: DOID:10128
in subset: NCIthesaurus

psychosexual disorder
type: Class
subclass of: sexual disorder
imported from: doid.owl
has cross-reference: ICD9CM:302.79
has cross-reference: UMLS_CUI:C0033951
has_obo_namespace: disease_ontology
id: DOID:10132

xerophthalmia
type: Class
subclass of: dry eye syndrome
imported from: doid.owl
has cross-reference: ICD10CM:E50.7
has cross-reference: ICD9CM:375.15
has cross-reference: MESH:D014985
has cross-reference: NCI:C34503
has cross-reference: SNOMEDCT_US_2020_03_01:193887002
has cross-reference: UMLS_CUI:C0043349
alternative_term: Conjunctival xerosis
has_obo_namespace: disease_ontology
id: DOID:10138
in subset: NCIthesaurus

conjunctival degeneration
type: Class
subclass of: conjunctival disease
subclass of: DOID 9799
imported from: doid.owl
has cross-reference: ICD10CM:H11.10
has cross-reference: ICD9CM:372.50
has cross-reference: SNOMEDCT_US_2020_03_01:40787005
has cross-reference: UMLS_CUI:C0155160
has_obo_namespace: disease_ontology
id: DOID:10139

dry eye syndrome
type: Class
subclass of: lacrimal apparatus disease
textual definition: A lacrimal apparatus disease that is characterized by persistent irritation or burning of the coreneal surface.
imported from: doid.owl
has cross-reference: ICD10CM:H04.12
has cross-reference: MESH:D015352
has cross-reference: NCI:C34553
has cross-reference: SNOMEDCT_US_2020_03_01:193980001
has cross-reference: UMLS_CUI:C0013238
alternative_term: Tear film insufficiency
alternative_term: dry eye disease
has_obo_namespace: disease_ontology
id: DOID:10140
in subset: NCIthesaurus

small intestine cancer
type: Class
subclass of: intestinal cancer
textual definition: An intestinal cancer that is located_in the small intestine.
imported from: doid.owl
has cross-reference: GARD:9385
has cross-reference: ICD10CM:C17
has cross-reference: ICD9CM:152.9
has cross-reference: NCI:C7523
has cross-reference: SNOMEDCT_US_2020_03_01:363509000
has cross-reference: UMLS_CUI:C0153425
has_obo_namespace: disease_ontology
id: DOID:10154
in subset: NCIthesaurus

intestinal cancer
type: Class
subclass of: gastrointestinal system cancer
subclass of: intestinal disease
textual definition: A gastrointestinal system cancer that is located_in the intestine.
imported from: doid.owl
has cross-reference: ICD10CM:C26.0
has cross-reference: ICD9CM:159.0
has cross-reference: MESH:D007414
has cross-reference: NCI:C4572
has cross-reference: SNOMEDCT_US_2020_03_01:93838000
has cross-reference: UMLS_CUI:C0346627
alternative_term: malignant intestinal tumors
alternative_term: malignant neoplasm of intestine
has_obo_namespace: disease_ontology
id: DOID:10155
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

osteonecrosis
type: Class
subclass of: ischemic bone disease
textual definition: An ischemic bone disease that results_in necrosis located_in bone.
imported from: doid.owl
has_alternative_id: DOID:10160
has_alternative_id: DOID:10161
has_alternative_id: DOID:10162
has_alternative_id: DOID:10163
has_alternative_id: DOID:10164
has_alternative_id: DOID:4128
has_alternative_id: DOID:8380
has_alternative_id: DOID:86
has cross-reference: ICD10CM:M87
has cross-reference: ICD10CM:M87.9
has cross-reference: ICD9CM:732.3
has cross-reference: ICD9CM:733.41
has cross-reference: ICD9CM:733.42
has cross-reference: ICD9CM:733.43
has cross-reference: ICD9CM:733.44
has cross-reference: MESH:D010020
has cross-reference: NCI:C34404
has cross-reference: NCI:C34841
has cross-reference: NCI:C34880
has cross-reference: NCI:C35226
has cross-reference: NCI:C35517
has cross-reference: SNOMEDCT_US_2020_03_01:156837008
has cross-reference: SNOMEDCT_US_2020_03_01:17926002
has cross-reference: SNOMEDCT_US_2020_03_01:240196003
has cross-reference: SNOMEDCT_US_2020_03_01:29281007
has cross-reference: SNOMEDCT_US_2020_03_01:43453000
has cross-reference: SNOMEDCT_US_2020_03_01:62100001
has cross-reference: SNOMEDCT_US_2020_03_01:83453001
has cross-reference: UMLS_CUI:C0003977
has cross-reference: UMLS_CUI:C0027543
has cross-reference: UMLS_CUI:C0029445
has cross-reference: UMLS_CUI:C0158442
has cross-reference: UMLS_CUI:C0158449
has cross-reference: UMLS_CUI:C0158450
has cross-reference: UMLS_CUI:C0158451
has cross-reference: UMLS_CUI:C0745048
alternative_term: Avascular necrosis of bone
alternative_term: aseptic necrosis
alternative_term: bone necrosis
has_obo_namespace: disease_ontology
id: DOID:10159
in subset: NCIthesaurus

skin lipoma
type: Class
subclass of: skin benign neoplasm
subclass of: lipoma
textual definition: A skin benign neoplasm that derives_from fat cells.
imported from: doid.owl
has_alternative_id: DOID:10198
has_alternative_id: DOID:3943
has cross-reference: ICD9CM:214.0
has cross-reference: NCI:C4616
has cross-reference: NCI:C5566
has cross-reference: SNOMEDCT_US_2020_03_01:255187008
has cross-reference: SNOMEDCT_US_2020_03_01:93159009
has cross-reference: UMLS_CUI:C0153968
has cross-reference: UMLS_CUI:C0347394
has cross-reference: UMLS_CUI:C1333174
alternative_term: Cutaneous Lipoma
alternative_term: Lipoma of skin
alternative_term: cutaneous lipomatous tumor
alternative_term: lipoma of face
has_obo_namespace: disease_ontology
id: DOID:10188
in subset: NCIthesaurus

osteomyelitis
type: Class
subclass of: disease by infectious agent
subclass of: bone inflammation disease
textual definition: A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow.
imported from: doid.owl
has_alternative_id: DOID:1018
has_alternative_id: DOID:1020
has_alternative_id: DOID:10281
has_alternative_id: DOID:10282
has_alternative_id: DOID:10692
has_alternative_id: DOID:10860
has_alternative_id: DOID:1164
has_alternative_id: DOID:11788
has_alternative_id: DOID:11959
has_alternative_id: DOID:12011
has_alternative_id: DOID:13673
has_alternative_id: DOID:13674
has_alternative_id: DOID:13675
has_alternative_id: DOID:13678
has_alternative_id: DOID:13684
has_alternative_id: DOID:13737
has_alternative_id: DOID:14003
has_alternative_id: DOID:14100
has_alternative_id: DOID:14166
has_alternative_id: DOID:2249
has_alternative_id: DOID:2250
has_alternative_id: DOID:5858
has_alternative_id: DOID:9456
has cross-reference: GARD:7286
has cross-reference: ICD9CM:730.1
has cross-reference: SNOMEDCT_US_2020_03_01:203181001
has cross-reference: UMLS_CUI:C0008707
has_obo_namespace: disease_ontology
id: DOID:1019

breast lipoma
type: Class
subclass of: breast benign neoplasm
subclass of: lipoma
textual definition: A breast benign neoplasm that is composed of lipocytes.
imported from: doid.owl
has cross-reference: NCI:C4647
has cross-reference: SNOMEDCT_US_2020_03_01:276891009
has cross-reference: UMLS_CUI:C0349565
alternative_term: Lipoma of breast
has_obo_namespace: disease_ontology
id: DOID:10199
in subset: NCIthesaurus

cholelithiasis
type: Class
subclass of: gallbladder disease
imported from: doid.owl
has cross-reference: EFO:0004799
has cross-reference: ICD9CM:574.5
has cross-reference: SNOMEDCT_US_2020_03_01:197397004
has cross-reference: UMLS_CUI:C0006739
has_obo_namespace: disease_ontology
id: DOID:10211

dermatomyositis
type: Class
subclass of: skin disease
subclass of: myositis
textual definition: A myositis that results_in inflammation located_in muscle or located_in skin where a skin rash is often seen prior to the onset of muscle weakness. The disease may result from either a viral infection or an autoimmune reaction.
imported from: doid.owl
has cross-reference: GARD:6263
has cross-reference: ICD10CM:M33
has cross-reference: ICD9CM:710.3
has cross-reference: MESH:D003882
has cross-reference: NCI:C26744
has cross-reference: SNOMEDCT_US_2020_03_01:38826005
has cross-reference: UMLS_CUI:C0011633
alternative_term: Polymyositis with skin involvement
alternative_term: dermatopolymyositis
has_obo_namespace: disease_ontology
has_related_synonym: Amyopathic dermatomyositis
id: DOID:10223
in subset: NCIthesaurus
comment: MESH:C538250 added from NeuroDevNet [WAK].

aortic atherosclerosis
type: Class
subclass of: atherosclerosis
imported from: doid.owl
has cross-reference: ICD10CM:I70.0
has cross-reference: ICD9CM:440.0
has cross-reference: SNOMEDCT_US_2020_03_01:81817003
has cross-reference: UMLS_CUI:C0155733
alternative_term: Aortic atherosclerosis
alternative_term: Atherosclerosis of aorta
has_obo_namespace: disease_ontology
id: DOID:10230

exhibitionism
type: Class
subclass of: paraphilia disorder
imported from: doid.owl
has cross-reference: ICD10CM:F65.2
has cross-reference: ICD9CM:302.4
has cross-reference: MESH:D005084
has cross-reference: NCI:C94352
has cross-reference: SNOMEDCT_US_2020_03_01:192514003
has cross-reference: UMLS_CUI:C0015269
has_obo_namespace: disease_ontology
id: DOID:10236
in subset: NCIthesaurus

leprosy
type: Class
subclass of: primary bacterial infectious disease
subclass of: testicular disease
subclass of: eye disease
subclass of: peripheral nervous system disease
subclass of: DOID 974
textual definition: A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.
imported from: doid.owl
has cross-reference: EFO:0001054
has cross-reference: GARD:6886
has cross-reference: ICD10CM:A30
has cross-reference: ICD9CM:030
has cross-reference: MESH:D007918
has cross-reference: NCI:C84824
has cross-reference: OMIM:607572
has cross-reference: OMIM:609888
has cross-reference: OMIM:613407
has cross-reference: ORDO:548
has cross-reference: SNOMEDCT_US_2020_03_01:154298007
has cross-reference: UMLS_CUI:C0023343
has_obo_namespace: disease_ontology
id: DOID:1024
in subset: DO rare slim
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease
comment: Xref MGI.

thalassemia
type: Class
subclass of: autosomal recessive disease
subclass of: hemolytic anemia
textual definition: A hemolytic anemia characterized by decreased synthesis of one or more hemoglobin polypeptide chains.
imported from: doid.owl
has_alternative_id: DOID:12242
has_alternative_id: DOID:12243
has cross-reference: GARD:7756
has cross-reference: ICD10CM:D56
has cross-reference: ICD9CM:282.4
has cross-reference: MESH:D013789
has cross-reference: NCI:C35069
has cross-reference: SNOMEDCT_US_2020_03_01:191192008
has cross-reference: UMLS_CUI:C0039730
alternative_term: Sickle-cell thalassemia with crisis
alternative_term: Sickle-cell thalassemia without crisis
alternative_term: thalassemia Hb-S disease with crisis
alternative_term: thalassemia Hb-S disease without crisis
has_obo_namespace: disease_ontology
id: DOID:10241
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

ehrlichiosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash.
imported from: doid.owl
has_alternative_id: DOID:0050023
has cross-reference: GARD:2092
has cross-reference: ICD10CM:A77.4
has cross-reference: ICD9CM:082.4
has cross-reference: MESH:D016873
has cross-reference: SNOMEDCT_US_2020_03_01:77361002
has cross-reference: UMLS_CUI:C0085399
alternative_term: human ehrlichiosis
has_obo_namespace: disease_ontology
id: DOID:10242
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease

pleurisy
type: Class
subclass of: pleural disease
textual definition: A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.
imported from: doid.owl
has cross-reference: ICD9CM:511.8
has cross-reference: UMLS_CUI:C0029799
has_obo_namespace: disease_ontology
id: DOID:10247

louping ill
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted by sheep tick, Ixodes ricinus. The infection has symptom lethargy, has symptom muscle pains, has symptom fever, and has symptom focal neurological signs.
imported from: doid.owl
has cross-reference: ICD10CM:A84.8
has cross-reference: ICD9CM:063.1
has cross-reference: MESH:D008146
has cross-reference: SNOMEDCT_US_2020_03_01:59350003
has cross-reference: UMLS_CUI:C0024025
alternative_term: Louping ill
has_obo_namespace: disease_ontology
id: DOID:10250
in subset: tick-borne infectious disease

mumps
type: Class
subclass of: salivary gland disease
subclass of: herpangina
textual definition: A viral infectious disease that results in inflammation located in salivary gland, has_material_basis_in Mumps rubulavirus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. The infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.
imported from: doid.owl
has cross-reference: GARD:7116
has cross-reference: ICD10CM:B26
has cross-reference: ICD9CM:072
has cross-reference: MESH:D009107
has cross-reference: NCI:C29888
has cross-reference: SNOMEDCT_US_2020_03_01:154352008
has cross-reference: UMLS_CUI:C0026780
has_obo_namespace: disease_ontology
id: DOID:10264
in subset: NCIthesaurus

heart conduction disease
type: Class
subclass of: heart disease
textual definition: A cardiovascular system disease that involves the heart's electrical conduction system.
imported from: doid.owl
has cross-reference: ICD9CM:426.6
has cross-reference: SNOMEDCT_US_2020_03_01:195053008
has cross-reference: UMLS_CUI:C0029630
alternative_term: heart rhythm disease
has_obo_namespace: disease_ontology
id: DOID:10273

prostate cancer
type: Class
subclass of: male reproductive organ cancer
subclass of: prostate disease
textual definition: A male reproductive organ cancer that is located_in the prostate.
imported from: doid.owl
has_alternative_id: DOID:514
has cross-reference: ICD10CM:C61
has cross-reference: ICD9CM:185
has cross-reference: KEGG:05215
has cross-reference: MESH:D011471
has cross-reference: NCI:C3343
has cross-reference: NCI:C7378
has cross-reference: OMIM:176807
has cross-reference: OMIM:300147
has cross-reference: OMIM:300704
has cross-reference: OMIM:601518
has cross-reference: OMIM:602759
has cross-reference: OMIM:608656
has cross-reference: OMIM:608658
has cross-reference: OMIM:609299
has cross-reference: OMIM:609558
has cross-reference: OMIM:610321
has cross-reference: OMIM:610997
has cross-reference: OMIM:611100
has cross-reference: OMIM:611868
has cross-reference: OMIM:611928
has cross-reference: OMIM:611955
has cross-reference: OMIM:611958
has cross-reference: OMIM:611959
has cross-reference: ORDO:1331
has cross-reference: SNOMEDCT_US_2020_03_01:126906006
has cross-reference: SNOMEDCT_US_2020_03_01:93974005
has cross-reference: UMLS_CUI:C0033578
has cross-reference: UMLS_CUI:C0376358
alternative_term: NGP - new growth of prostate
alternative_term: hereditary prostate cancer
alternative_term: malignant tumor of the prostate
alternative_term: prostate cancer, familial
alternative_term: prostate neoplasm
alternative_term: prostatic cancer
alternative_term: prostatic neoplasm
alternative_term: tumor of the prostate
has_obo_namespace: disease_ontology
id: DOID:10283
in subset: DO FlyBase slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

familial periodic paralysis
type: Class
subclass of: DOID 896
imported from: doid.owl
has cross-reference: GARD:6422
has cross-reference: ICD10CM:G72.3
has cross-reference: MESH:D010245
has cross-reference: NCI:C84709
has cross-reference: SNOMEDCT_US_2020_03_01:193241004
has cross-reference: UMLS_CUI:C0030443
has_obo_namespace: disease_ontology
id: DOID:1029
in subset: NCIthesaurus

Raynaud disease
type: Class
subclass of: peripheral vascular disease
imported from: doid.owl
has cross-reference: ICD10CM:I73.0
has cross-reference: MESH:D011928
has cross-reference: OMIM:179600
has cross-reference: SNOMEDCT_US_2020_03_01:195295006
has cross-reference: UMLS_CUI:C0034734
alternative_term: Raynaud's disease
alternative_term: Raynaud's syndrome
has_obo_namespace: disease_ontology
id: DOID:10300
comment: OMIM mapping confirmed by DO. [SN].

parotitis
type: Class
subclass of: parotid disease
textual definition: A parotid disease characterized by the inflammation of one or both parotid glands.
imported from: doid.owl
has cross-reference: ICD10CM:K11.2
has cross-reference: MESH:D010309
has cross-reference: NCI:C114281
has cross-reference: SNOMEDCT_US_2020_03_01:196481002
has cross-reference: UMLS_CUI:C0030583
has_obo_namespace: disease_ontology
id: DOID:10301
in subset: NCIthesaurus

parotid disease
type: Class
subclass of: salivary gland disease
imported from: doid.owl
has cross-reference: MESH:D010305
has cross-reference: UMLS_CUI:C0030579
has_obo_namespace: disease_ontology
id: DOID:10302

sialadenitis
type: Class
subclass of: salivary gland disease
subclass of: lymphadenitis
imported from: doid.owl
has cross-reference: GARD:7638
has cross-reference: ICD10CM:K11.2
has cross-reference: ICD9CM:527.2
has cross-reference: MESH:D012793
has cross-reference: NCI:C26882
has cross-reference: SNOMEDCT_US_2020_03_01:42982001
has cross-reference: UMLS_CUI:C0037023
alternative_term: Sialoadenitis
has_obo_namespace: disease_ontology
id: DOID:10303
in subset: NCIthesaurus

endocarditis
type: Class
subclass of: endocardium disease
textual definition: A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.
imported from: doid.owl
has_alternative_id: DOID:14058
has cross-reference: ICD10CM:I33.9
has cross-reference: ICD9CM:421.9
has cross-reference: MESH:D004696
has cross-reference: NCI:C34582
has cross-reference: NCI:C35432
has cross-reference: SNOMEDCT_US_2020_03_01:56819008
has cross-reference: SNOMEDCT_US_2020_03_01:91357005
has cross-reference: UMLS_CUI:C0014118
has cross-reference: UMLS_CUI:C0375268
has_obo_namespace: disease_ontology
id: DOID:10314
in subset: NCIthesaurus

pneumoconiosis
type: Class
subclass of: interstitial lung disease
textual definition: An interstitial lung disease that is caused by the inhalation of dust.
imported from: doid.owl
has cross-reference: ICD10CM:J64
has cross-reference: ICD9CM:505
has cross-reference: MESH:D011009
has cross-reference: NCI:C26861
has cross-reference: SNOMEDCT_US_2020_03_01:196004000
has cross-reference: UMLS_CUI:C0032273
has_obo_namespace: disease_ontology
id: DOID:10316
in subset: NCIthesaurus

asbestosis
type: Class
subclass of: pneumoconiosis
textual definition: A pneumoconiosis caused by inhalation and retention of asbestos fibers.
imported from: doid.owl
has cross-reference: GARD:5852
has cross-reference: ICD10CM:J61
has cross-reference: ICD9CM:501
has cross-reference: MESH:D001195
has cross-reference: NCI:C84573
has cross-reference: SNOMEDCT_US_2020_03_01:266400008
has cross-reference: UMLS_CUI:C0003949
has_obo_namespace: disease_ontology
id: DOID:10320
in subset: NCIthesaurus

byssinosis
type: Class
subclass of: pneumoconiosis
imported from: doid.owl
has cross-reference: GARD:5976
has cross-reference: ICD10CM:J66.0
has cross-reference: MESH:D002095
has cross-reference: NCI:C84605
has cross-reference: SNOMEDCT_US_2020_03_01:155589004
has cross-reference: UMLS_CUI:C0006542
alternative_term: Flax-dressers' disease
alternative_term: Stripper's asthma
alternative_term: cotton mill fever
has_obo_namespace: disease_ontology
id: DOID:10323
in subset: NCIthesaurus

silicosis
type: Class
subclass of: pneumoconiosis
textual definition: A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.
imported from: doid.owl
has_alternative_id: DOID:14007
has cross-reference: GARD:7647
has cross-reference: ICD10CM:J62.8
has cross-reference: ICD9CM:502
has cross-reference: MESH:D012829
has cross-reference: NCI:C3369
has cross-reference: SNOMEDCT_US_2020_03_01:155590008
has cross-reference: UMLS_CUI:C0037116
alternative_term: Pneumoconiosis due to silicates
alternative_term: Silica pneumoconiosis
alternative_term: Silicotic fibrosis of lung
alternative_term: silicotuberculosis
has_obo_namespace: disease_ontology
id: DOID:10325
in subset: NCIthesaurus

anthracosis
type: Class
subclass of: pneumoconiosis
imported from: doid.owl
has cross-reference: ICD10CM:J60
has cross-reference: ICD9CM:500
has cross-reference: MESH:D055008
has cross-reference: NCI:C34390
has cross-reference: SNOMEDCT_US_2020_03_01:29422001
has cross-reference: UMLS_CUI:C0003165
alternative_term: Coal Miner's Pneumoconiosis
alternative_term: Coal workers' lung
alternative_term: Coal workers' pneumoconiosis
alternative_term: Melanoedema
alternative_term: black lung
has_obo_namespace: disease_ontology
id: DOID:10327
in subset: NCIthesaurus

siderosis
type: Class
subclass of: pneumoconiosis
imported from: doid.owl
has cross-reference: GARD:7645
has cross-reference: ICD10CM:J63.4
has cross-reference: MESH:D012806
has cross-reference: SNOMEDCT_US_2020_03_01:155591007
has cross-reference: UMLS_CUI:C0037061
alternative_term: pulmonary siderosis
has_obo_namespace: disease_ontology
id: DOID:10328

blepharophimosis
type: Class
subclass of: eyelid disease
imported from: doid.owl
has cross-reference: GARD:5932
has cross-reference: ICD10CM:H02.52
has cross-reference: ICD9CM:374.46
has cross-reference: MESH:D016569
has cross-reference: UMLS_CUI:C0005744
has_obo_namespace: disease_ontology
id: DOID:10348

breast cyst
type: Class
subclass of: breast benign neoplasm
textual definition: A breast benign neoplasm that is characterized by a fluid-filled sac.
imported from: doid.owl
has cross-reference: ICD10CM:N60.0
has cross-reference: MESH:D047688
has cross-reference: NCI:C5315
has cross-reference: SNOMEDCT_US_2020_03_01:56726003
has cross-reference: UMLS_CUI:C0006144
alternative_term: Cyst of the breast
has_obo_namespace: disease_ontology
id: DOID:10350
in subset: NCIthesaurus

lymphoid leukemia
type: Class
subclass of: leukemia
textual definition: A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood.
imported from: doid.owl
has_alternative_id: DOID:10747
has cross-reference: ICD10CM:C91
has cross-reference: ICD9CM:204
has cross-reference: MESH:D007945
has cross-reference: NCI:C7539
has cross-reference: SNOMEDCT_US_2020_03_01:93170002
has cross-reference: UMLS_CUI:C0023448
alternative_term: lymphoblastic leukaemia
alternative_term: lymphoblastic leukemia
alternative_term: lymphocytic leukaemia
alternative_term: lymphoid leukemia
has_obo_namespace: disease_ontology
id: DOID:1037
in subset: DO cancer slim
in subset: NCIthesaurus

yaws
type: Class
subclass of: primary bacterial infectious disease
subclass of: bone disease
subclass of: skin disease
textual definition: A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. The infection has symptom skin lesions.
imported from: doid.owl
has cross-reference: GARD:7913
has cross-reference: ICD10CM:A66
has cross-reference: ICD9CM:102
has cross-reference: MESH:D015001
has cross-reference: NCI:C41353
has cross-reference: SNOMEDCT_US_2020_03_01:266213004
has cross-reference: UMLS_CUI:C0043388
alternative_term: Bouba
alternative_term: frambesia
alternative_term: frambesia tropica
alternative_term: frambosie
alternative_term: polypapilloma tropicum
alternative_term: thymosis
has_obo_namespace: disease_ontology
id: DOID:10371
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease

suppression amblyopia
type: Class
subclass of: amblyopia
imported from: doid.owl
has cross-reference: ICD10CM:H53.03
has cross-reference: ICD9CM:368.01
has cross-reference: MESH:D000550
has cross-reference: SNOMEDCT_US_2020_03_01:35600002
has cross-reference: UMLS_CUI:C0750903
alternative_term: Strabismic amblyopia
has_obo_namespace: disease_ontology
id: DOID:10375

amblyopia
type: Class
subclass of: eye disease
textual definition: An eye disease that is characterized by poor vision in one eye resulting from the brain failing to process inputs from one eye and over time favors the other eye.
imported from: doid.owl
has cross-reference: ICD10CM:H53.00
has cross-reference: ICD9CM:368.00
has cross-reference: MESH:D000550
has cross-reference: NCI:C118764
has cross-reference: SNOMEDCT_US_2020_03_01:155145007
has cross-reference: UMLS_CUI:C0002418
has_obo_namespace: disease_ontology
id: DOID:10376
in subset: NCIthesaurus

disuse amblyopia
type: Class
subclass of: amblyopia
imported from: doid.owl
has cross-reference: ICD10CM:H53.01
has cross-reference: ICD9CM:368.02
has cross-reference: SNOMEDCT_US_2020_03_01:193638002
has cross-reference: UMLS_CUI:C0152189
alternative_term: Deprivation amblyopia
has_obo_namespace: disease_ontology
id: DOID:10378

prolymphocytic leukemia
type: Class
subclass of: chronic lymphocytic leukemia
imported from: doid.owl
has cross-reference: MESH:D015463
has cross-reference: NCI:C3181
has cross-reference: SNOMEDCT_US_2020_03_01:110006004
has cross-reference: UMLS_CUI:C0023486
has_obo_namespace: disease_ontology
id: DOID:1039
in subset: NCIthesaurus

secondary hypertrophic osteoarthropathy
type: Class
subclass of: arthropathy
imported from: doid.owl
has cross-reference: ICD10CM:M89.4
has cross-reference: ICD9CM:731.2
has cross-reference: MESH:D010005
has cross-reference: SNOMEDCT_US_2020_03_01:46922002
has cross-reference: UMLS_CUI:C0029412
alternative_term: Bamberger-Marie disease
alternative_term: HPOA - hypertrophic pulmonary osteoarthropathy
alternative_term: Marie Bamberger disease
alternative_term: hypertrophic pulmonary osteoarthropathy
has_obo_namespace: disease_ontology
id: DOID:10393

pneumonic plague
type: Class
subclass of: plague
subclass of: lung disease
textual definition: A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing.
imported from: doid.owl
has_alternative_id: DOID:10401
has_alternative_id: DOID:10402
has cross-reference: ICD10CM:A20.2
has cross-reference: ICD9CM:020.3
has cross-reference: ICD9CM:020.4
has cross-reference: ICD9CM:020.5
has cross-reference: MESH:D010930
has cross-reference: SNOMEDCT_US_2020_03_01:35339003
has cross-reference: SNOMEDCT_US_2020_03_01:38976008
has cross-reference: SNOMEDCT_US_2020_03_01:67525007
has cross-reference: UMLS_CUI:C0152937
has cross-reference: UMLS_CUI:C0152938
has cross-reference: UMLS_CUI:C0524688
alternative_term: primary pneumonic plague
alternative_term: secondary pneumonic plague
has_obo_namespace: disease_ontology
id: DOID:10398
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

bacterial infectious disease
type: Class
subclass of: disease by infectious agent
textual definition: A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.
imported from: doid.owl
has cross-reference: ICD10CM:A49.9
has cross-reference: MESH:D001424
has cross-reference: NCI:C2890
has cross-reference: SNOMEDCT_US_2020_03_01:87628006
has cross-reference: UMLS_CUI:C0004623
has_obo_namespace: disease_ontology
id: DOID:104
in subset: DO AGR slim
in subset: DO FlyBase slim
in subset: NCIthesaurus

chronic lymphocytic leukemia
type: Class
subclass of: lymphoma
subclass of: lymphoid leukemia
textual definition: A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood.
imported from: doid.owl
has cross-reference: EFO:0000095
has cross-reference: GARD:6104
has cross-reference: ICD10CM:C91.10
has cross-reference: ICD9CM:204.1
has cross-reference: MESH:D015451
has cross-reference: NCI:C3163
has cross-reference: OMIM:109543
has cross-reference: OMIM:151400
has cross-reference: OMIM:609630
has cross-reference: OMIM:612557
has cross-reference: OMIM:612558
has cross-reference: OMIM:612559
has cross-reference: ORDO:67038
has cross-reference: SNOMEDCT_US_2020_03_01:51092000
has cross-reference: UMLS_CUI:C0023434
alternative_term: B-cell chronic lymphocytic leukaemia
alternative_term: B-cell chronic lymphocytic leukemia
alternative_term: CLL
alternative_term: chronic lymphatic leukaemia
alternative_term: chronic lymphatic leukemia
alternative_term: chronic lymphocytic leukaemia
alternative_term: lymphoplasmacytic leukaemia
alternative_term: lymphoplasmacytic leukemia
has_obo_namespace: disease_ontology
has_related_synonym: B-cell chronic lymphoid leukemia
id: DOID:1040
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

Klippel-Feil syndrome
type: Class
subclass of: spinal disease
subclass of: physical disorder
subclass of: syndrome
textual definition: A physical disorder that is characterized by abnormal segmentation of the vertebra during fetal development which results in fusion located in cervical vertebra.
imported from: doid.owl
has_alternative_id: DOID:14747
has cross-reference: GARD:10280
has cross-reference: ICD10CM:Q76.1
has cross-reference: ICD9CM:756.16
has cross-reference: MESH:D007714
has cross-reference: NCI:C98967
has cross-reference: OMIM:PS118100
has cross-reference: ORDO:2345
has cross-reference: SNOMEDCT_US_2020_03_01:268349005
has cross-reference: UMLS_CUI:C0022738
alternative_term: Klippel-Feil and Turner syndrome
alternative_term: Klippel-Feil deformity, deafness and facial asymmetry
alternative_term: autosomal dominant Klippel-Feil syndrome
alternative_term: congenital dystrophia brevicollis
alternative_term: congenital synostosis of cervical vertebrae
has_obo_namespace: disease_ontology
id: DOID:10426
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Mooren's ulcer
type: Class
subclass of: corneal ulcer
textual definition: A corneal ulcer that is characterized by painful peripheral corneal ulceration, sterile limbal inflammation, and episcleral and conjunctival edema.
imported from: doid.owl
has cross-reference: ICD10CM:H16.05
has cross-reference: ICD9CM:370.07
has cross-reference: SNOMEDCT_US_2020_03_01:22440001
has cross-reference: UMLS_CUI:C0155072
alternative_term: Mooren ulcer
has_obo_namespace: disease_ontology
id: DOID:10439

tonsillitis
type: Class
subclass of: DOID 974
textual definition: An upper respiratory tract disease which is characterized by inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat, painful or difficult swallowing, coughing, headache, myalgia, fever and chills.
imported from: doid.owl
has_alternative_id: DOID:10454
has_alternative_id: DOID:13751
has cross-reference: ICD10CM:J35.01
has cross-reference: ICD9CM:474.00
has cross-reference: MESH:D014069
has cross-reference: NCI:C116006
has cross-reference: SNOMEDCT_US_2020_03_01:195665006
has cross-reference: SNOMEDCT_US_2020_03_01:195794009
has cross-reference: UMLS_CUI:C0040425
has cross-reference: UMLS_CUI:C0149517
alternative_term: Throat infection - tonsillitis
alternative_term: chronic tonsillitis
has_obo_namespace: disease_ontology
id: DOID:10456
in subset: NCIthesaurus

Legionnaires' disease
type: Class
subclass of: legionellosis
textual definition: A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.
imported from: doid.owl
has cross-reference: ICD10CM:A48.1
has cross-reference: ICD9CM:482.84
has cross-reference: MESH:D007877
has cross-reference: NCI:C128339
has cross-reference: SNOMEDCT_US_2020_03_01:195889001
has cross-reference: UMLS_CUI:C0023241
alternative_term: Infection by Legionella pneumophilia
alternative_term: Legionella
alternative_term: Legionella pneumonia
alternative_term: Legionnaire's disease
has_obo_namespace: disease_ontology
id: DOID:10457
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease

legionellosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.
imported from: doid.owl
has cross-reference: MESH:D007876
has cross-reference: NCI:C128334
has cross-reference: SNOMEDCT_US_2020_03_01:26726000
has cross-reference: UMLS_CUI:C0023240
alternative_term: Legionella infection
has_obo_namespace: disease_ontology
id: DOID:10458
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease

common cold
type: Class
subclass of: DOID 974
textual definition: An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.
imported from: doid.owl
has cross-reference: ICD10CM:J00
has cross-reference: ICD9CM:460
has cross-reference: MESH:D003139
has cross-reference: NCI:C34500
has cross-reference: SNOMEDCT_US_2020_03_01:195648002
has cross-reference: UMLS_CUI:C0009443
alternative_term: Acute viral rhinopharyngitis
alternative_term: Nasopharyngitis - acute
alternative_term: Nasopharyngitis, acute
alternative_term: acute Nasopharyngitis
alternative_term: acute coryza
alternative_term: acute nasopharyngitis
alternative_term: acute rhinitis
alternative_term: rhino-sinusitis
has_obo_namespace: disease_ontology
id: DOID:10459
in subset: NCIthesaurus

nasopharyngitis
type: Class
subclass of: DOID 9561
textual definition: A nasopharyngeal disease which involves inflammation of the nasal passages and upper part of the pharynx.
imported from: doid.owl
has_alternative_id: DOID:11587
has cross-reference: ICD10CM:J00
has cross-reference: ICD10CM:J31.1
has cross-reference: ICD9CM:472.2
has cross-reference: MESH:D009304
has cross-reference: NCI:C34837
has cross-reference: SNOMEDCT_US_2020_03_01:155524006
has cross-reference: SNOMEDCT_US_2020_03_01:51476001
has cross-reference: UMLS_CUI:C0027441
has cross-reference: UMLS_CUI:C0155826
alternative_term: chronic nasopharyngitis
has_obo_namespace: disease_ontology
id: DOID:10460
in subset: NCIthesaurus

dentin caries
type: Class
subclass of: dental caries
imported from: doid.owl
has cross-reference: ICD10CM:K02
has cross-reference: ICD9CM:521.02
has cross-reference: SNOMEDCT_US_2020_03_01:442551007
has cross-reference: UMLS_CUI:C0266846
alternative_term: Compound dental caries
alternative_term: Dental caries extending into dentine
alternative_term: Dentin caries
has_obo_namespace: disease_ontology
id: DOID:10461

patellar tendinitis
type: Class
subclass of: DOID 971
imported from: doid.owl
has cross-reference: ICD10CM:M76.5
has cross-reference: ICD9CM:726.64
has cross-reference: SNOMEDCT_US_2020_03_01:156662006
has cross-reference: UMLS_CUI:C0158317
alternative_term: Patellar tendonitis
has_obo_namespace: disease_ontology
id: DOID:10471

diaphragmatic eventration
type: Class
subclass of: diaphragm disease
imported from: doid.owl
has cross-reference: ICD10CM:Q79.1
has cross-reference: MESH:D003965
has cross-reference: NCI:C98912
has cross-reference: SNOMEDCT_US_2020_03_01:34168003
has cross-reference: UMLS_CUI:C0011981
has_obo_namespace: disease_ontology
id: DOID:10480
in subset: NCIthesaurus

diaphragm disease
type: Class
subclass of: muscular disease
textual definition: A muscular disease that is located_in the diaphragm.
imported from: doid.owl
has cross-reference: ICD10CM:J98.6
has cross-reference: ICD9CM:519.4
has cross-reference: SNOMEDCT_US_2020_03_01:48475001
has cross-reference: UMLS_CUI:C0152097
has_obo_namespace: disease_ontology
id: DOID:10481

esophageal atresia
type: Class
subclass of: esophageal disease
imported from: doid.owl
has cross-reference: GARD:6381
has cross-reference: ICD10CM:Q39.0
has cross-reference: MESH:D004933
has cross-reference: NCI:C87072
has cross-reference: SNOMEDCT_US_2020_03_01:156947007
has cross-reference: UMLS_CUI:C0014850
alternative_term: Congenital atresia of esophagus
alternative_term: Congenital imperforate esophagus
alternative_term: Imperforate esophagus
alternative_term: Oesophageal atresia
has_obo_namespace: disease_ontology
id: DOID:10485
in subset: NCIthesaurus

intestinal atresia
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: ICD10CM:Q41.1
has cross-reference: MESH:D007409
has cross-reference: NCI:C84790
has cross-reference: UMLS_CUI:C0021828
has_obo_namespace: disease_ontology
id: DOID:10486
in subset: NCIthesaurus

Hirschsprung's disease
type: Class
subclass of: megacolon
textual definition: A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.
imported from: doid.owl
has cross-reference: GARD:6660
has cross-reference: ICD10CM:Q43.1
has cross-reference: MESH:D006627
has cross-reference: NCI:C34700
has cross-reference: OMIM:600156
has cross-reference: OMIM:606874
has cross-reference: OMIM:606875
has cross-reference: OMIM:608462
has cross-reference: OMIM:611644
has cross-reference: ORDO:388
has cross-reference: SNOMEDCT_US_2020_03_01:204739008
has cross-reference: UMLS_CUI:C0019569
alternative_term: Hirschsprung disease
alternative_term: aganglionic megacolon
alternative_term: congenital megacolon
alternative_term: macrocolon
alternative_term: pelvirectal achalasia
alternative_term: total intestinal aganglionosis
has_obo_namespace: disease_ontology
id: DOID:10487
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

imperforate anus
type: Class
subclass of: physical disorder
subclass of: anus disease
imported from: doid.owl
has cross-reference: GARD:6769
has cross-reference: ICD10CM:Q42.3
has cross-reference: MESH:D001006
has cross-reference: NCI:C84784
has cross-reference: OMIM:207500
has cross-reference: OMIM:301800
has cross-reference: SNOMEDCT_US_2020_03_01:156956004
has cross-reference: UMLS_CUI:C0003466
alternative_term: Congenital atresia of anus
alternative_term: Congenital or infantile occlusion of anus
alternative_term: Imperforate anus
alternative_term: anal atresia
has_obo_namespace: disease_ontology
id: DOID:10488
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

adrenal cortical hypofunction
type: Class
subclass of: adrenal cortex disease
imported from: doid.owl
has cross-reference: ICD9CM:255.4
has cross-reference: NCI:C26691
has cross-reference: SNOMEDCT_US_2020_03_01:68588005
has cross-reference: UMLS_CUI:C0405580
alternative_term: Adrenal Cortical Insufficiency
alternative_term: Corticoadrenal insufficiency
has_obo_namespace: disease_ontology
id: DOID:10493
in subset: NCIthesaurus

viral pneumonia
type: Class
subclass of: pneumonia
subclass of: DOID 934
textual definition: A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus.
imported from: doid.owl
has_alternative_id: DOID:13167
has cross-reference: ICD10CM:J12.9
has cross-reference: ICD9CM:480
has cross-reference: MESH:D011024
has cross-reference: SNOMEDCT_US_2020_03_01:195880002
has cross-reference: UMLS_CUI:C0032310
has_obo_namespace: disease_ontology
id: DOID:10533

stomach cancer
type: Class
subclass of: gastrointestinal system cancer
subclass of: stomach disease
textual definition: A gastrointestinal system cancer that is located_in the stomach.
imported from: doid.owl
has_alternative_id: DOID:10539
has_alternative_id: DOID:10542
has_alternative_id: DOID:10543
has_alternative_id: DOID:4713
has cross-reference: GARD:7704
has cross-reference: ICD10CM:C16
has cross-reference: ICD10CM:C16.2
has cross-reference: ICD10CM:C16.5
has cross-reference: ICD10CM:C16.6
has cross-reference: ICD9CM:151
has cross-reference: ICD9CM:151.4
has cross-reference: ICD9CM:151.5
has cross-reference: ICD9CM:151.6
has cross-reference: MESH:D013274
has cross-reference: NCI:C3387
has cross-reference: NCI:C9331
has cross-reference: OMIM:613659
has cross-reference: SNOMEDCT_US_2020_03_01:126824007
has cross-reference: SNOMEDCT_US_2020_03_01:269459004
has cross-reference: SNOMEDCT_US_2020_03_01:269460009
has cross-reference: SNOMEDCT_US_2020_03_01:93717002
has cross-reference: SNOMEDCT_US_2020_03_01:94074003
has cross-reference: UMLS_CUI:C0024623
has cross-reference: UMLS_CUI:C0038356
has cross-reference: UMLS_CUI:C0153421
has cross-reference: UMLS_CUI:C0153422
has cross-reference: UMLS_CUI:C0153423
alternative_term: gastric cancer
alternative_term: gastric neoplasm
has_obo_namespace: disease_ontology
id: DOID:10534
in subset: DO FlyBase slim
in subset: DO cancer slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: OMIM mapping confirmed by DO. [SN].

gastric lymphoma
type: Class
subclass of: lymphoma
subclass of: stomach cancer
imported from: doid.owl
has cross-reference: GARD:6485
has cross-reference: NCI:C4636
has cross-reference: SNOMEDCT_US_2020_03_01:276811008
has cross-reference: UMLS_CUI:C0349532
alternative_term: Lymphoma of the stomach
has_obo_namespace: disease_ontology
id: DOID:10540
in subset: NCIthesaurus

cardia cancer
type: Class
subclass of: stomach cancer
imported from: doid.owl
has cross-reference: ICD10CM:C16.0
has cross-reference: ICD9CM:151.0
has cross-reference: SNOMEDCT_US_2020_03_01:93738008
has cross-reference: UMLS_CUI:C0153417
alternative_term: Ca cardia - stomach
alternative_term: malignant neoplasm of cardia of stomach
has_obo_namespace: disease_ontology
id: DOID:10548

meningoencephalitis
type: Class
subclass of: central nervous system disease
textual definition: A central nervous system disease that involves encephalitis which occurs along with meningitis.
imported from: doid.owl
has cross-reference: ICD10CM:A69.22
has cross-reference: MESH:D008590
has cross-reference: NCI:C34813
has cross-reference: SNOMEDCT_US_2020_03_01:7125002
has cross-reference: UMLS_CUI:C0025309
alternative_term: Meningoencephalitis
has_obo_namespace: disease_ontology
id: DOID:10554
in subset: NCIthesaurus

oculocerebrorenal syndrome
type: Class
subclass of: X-linked recessive disease
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in mutation in the OCRL gene on chromosome Xq26 and that is characterized by hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, amino aciduria, and reduced ammonia production by the kidney.
imported from: doid.owl
has cross-reference: GARD:3295
has cross-reference: ICD10CM:E72.03
has cross-reference: MEDDRA:10051707
has cross-reference: MESH:D009800
has cross-reference: NCI:C84940
has cross-reference: OMIM:309000
has cross-reference: ORDO:534
has cross-reference: SNOMEDCT_US_2020_03_01:79385002
has cross-reference: UMLS_CUI:C0028860
alternative_term: Lowe syndrome
alternative_term: lowe oculocerebrorenal syndrome
alternative_term: oculocerebrorenal syndrome of Lowe
has_obo_namespace: disease_ontology
id: DOID:1056
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

osteomalacia
type: Class
subclass of: bone remodeling disease
textual definition: A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone.
imported from: doid.owl
has cross-reference: GARD:7285
has cross-reference: ICD9CM:268.2
has cross-reference: NCI:C26838
has cross-reference: SNOMEDCT_US_2020_03_01:190639009
has cross-reference: UMLS_CUI:C0029442
has_obo_namespace: disease_ontology
id: DOID:10573
in subset: NCIthesaurus

calcium metabolism disease
type: Class
subclass of: mineral metabolism disease
imported from: doid.owl
has cross-reference: ICD10CM:E83.5
has cross-reference: ICD9CM:275.4
has cross-reference: MESH:D002128
has cross-reference: SNOMEDCT_US_2020_03_01:267442002
has cross-reference: UMLS_CUI:C0006705
has_obo_namespace: disease_ontology
id: DOID:10575

leukodystrophy
type: Class
subclass of: cerebral degeneration
textual definition: A cerebral degeneration characterized by dysfunction of the white matter of the brain.
imported from: doid.owl
has cross-reference: GARD:6895
has cross-reference: ICD9CM:330.0
has cross-reference: NCI:C61253
has cross-reference: SNOMEDCT_US_2020_03_01:5101009
has cross-reference: UMLS_CUI:C0023520
has_obo_namespace: disease_ontology
id: DOID:10579
in subset: NCIthesaurus

metachromatic leukodystrophy
type: Class
subclass of: sphingolipidosis
textual definition: A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system.
imported from: doid.owl
has cross-reference: GARD:3230
has cross-reference: ICD10CM:E75.25
has cross-reference: MESH:D007966
has cross-reference: NCI:C61251
has cross-reference: OMIM:249900
has cross-reference: OMIM:250100
has cross-reference: ORDO:512
has cross-reference: SNOMEDCT_US_2020_03_01:3621006
has cross-reference: UMLS_CUI:C0023522
alternative_term: MLD
alternative_term: Scholz cerebral sclerosis
alternative_term: arylsulfatase A deficiency
alternative_term: deficiency of cerebroside-sulfatase
alternative_term: sulfatide lipoidosis
has_obo_namespace: disease_ontology
id: DOID:10581
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Refsum disease
type: Class
subclass of: lipid metabolism disorder
imported from: doid.owl
has cross-reference: GARD:5691
has cross-reference: ICD10CM:G60.1
has cross-reference: ICD9CM:356.3
has cross-reference: MESH:D012035
has cross-reference: NCI:C85043
has cross-reference: OMIM:266500
has cross-reference: OMIM:266510
has cross-reference: SNOMEDCT_US_2020_03_01:25362006
has cross-reference: UMLS_CUI:C0034960
alternative_term: HMSN type IV
alternative_term: HSMN IV
alternative_term: Heredopathia atactica polyneuritiformis
alternative_term: Refsum's disease
has_obo_namespace: disease_ontology
id: DOID:10582
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

retinitis pigmentosa
type: Class
subclass of: retinal degeneration
textual definition: A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss.
imported from: doid.owl
has_alternative_id: DOID:14742
has cross-reference: GARD:5694
has cross-reference: ICD10CM:H35.52
has cross-reference: MESH:C538365
has cross-reference: MESH:D012174
has cross-reference: NCI:C85045
has cross-reference: OMIM:PS268000
has cross-reference: ORDO:791
has cross-reference: SNOMEDCT_US_2020_03_01:155113002
has cross-reference: UMLS_CUI:C0035334
has cross-reference: UMLS_CUI:C0220701
alternative_term: pericentral pigmentary retinopathy
has_obo_namespace: disease_ontology
id: DOID:10584
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [LS].

Krabbe disease
type: Class
subclass of: sphingolipidosis
imported from: doid.owl
has cross-reference: GARD:6844
has cross-reference: ICD10CM:E75.23
has cross-reference: MESH:D007965
has cross-reference: NCI:C61254
has cross-reference: OMIM:245200
has cross-reference: SNOMEDCT_US_2020_03_01:192782005
has cross-reference: UMLS_CUI:C0023521
alternative_term: Diffuse globoInOwlid body sclerosis
alternative_term: GLOBOID CELL LEUKOENCEPHALOPATHY
alternative_term: Galactosylceramide beta-galactosidase deficiency
alternative_term: Krabbe's disease
alternative_term: Krabbe's leukodystrophy
alternative_term: beta galactocerebrosidase deficiency
alternative_term: globoInOwlid cell leukodystrophy
has_obo_namespace: disease_ontology
id: DOID:10587
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

adrenoleukodystrophy
type: Class
subclass of: X-linked recessive disease
subclass of: leukodystrophy
textual definition: A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death.
imported from: doid.owl
has_alternative_id: DOID:13451
has cross-reference: ICD10CM:E71.52
has cross-reference: MESH:D000326
has cross-reference: NCI:C61252
has cross-reference: OMIM:300100
has cross-reference: SNOMEDCT_US_2020_03_01:65389002
has cross-reference: UMLS_CUI:C0162309
alternative_term: ALD
alternative_term: Bronze Schilder disease
alternative_term: Encephalitis periaxialis concentrica
alternative_term: Encephalitis periaxialis, Schilder's
alternative_term: Siemerling-Creutzfeldt Disease
alternative_term: X-linked adrenoleukodystrophy
alternative_term: diffuse sclerosis
alternative_term: sudanophilic cerebral sclerosis
has_obo_namespace: disease_ontology
id: DOID:10588
in subset: NCIthesaurus
comment: MESH:D000326w added from NeuroDevNet [WAK].

intellectual disability
type: Class
subclass of: specific developmental disorder
textual definition: A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.
imported from: doid.owl
has cross-reference: NCI:C84392
has cross-reference: SNOMEDCT_US_2020_03_01:1855002
has cross-reference: UMLS_CUI:C0025362
alternative_term: MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15
has_obo_namespace: disease_ontology
has_related_synonym: mental retardation
id: DOID:1059
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping submitted by NeuroDevNet. [LS].

pre-eclampsia
type: Class
subclass of: hypertension
textual definition: A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.
imported from: doid.owl
has_alternative_id: DOID:12684
has cross-reference: ICD10CM:O14
has cross-reference: MESH:D011225
has cross-reference: NCI:C85021
has cross-reference: OMIM:189800
has cross-reference: OMIM:609402
has cross-reference: OMIM:609403
has cross-reference: OMIM:609404
has cross-reference: OMIM:614592
has cross-reference: ORDO:275555
has cross-reference: SNOMEDCT_US_2020_03_01:6758009
has cross-reference: UMLS_CUI:C0032914
alternative_term: gestational hypertension
alternative_term: hypertension induced by pregnancy
alternative_term: pre-eclamptic toxaemia
alternative_term: preeclampsia
alternative_term: preeclampsia/eclampsia
alternative_term: pregnancy associated hypertension
alternative_term: pregnancy toxemia
alternative_term: proteinuric hypertension of pregnancy
alternative_term: toxaemia of pregnancy
has_obo_namespace: disease_ontology
id: DOID:10591
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Charcot-Marie-Tooth disease
type: Class
subclass of: neuromuscular disease
textual definition: A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm.
imported from: doid.owl
has cross-reference: GARD:6034
has cross-reference: ICD10CM:G60.0
has cross-reference: ICD9CM:356.1
has cross-reference: MESH:D002607
has cross-reference: NCI:C75467
has cross-reference: OMIM:PS118220
has cross-reference: SNOMEDCT_US_2020_03_01:193158000
has cross-reference: UMLS_CUI:C0007959
alternative_term: CMT - Charcot-Marie-Tooth disease
has_obo_namespace: disease_ontology
id: DOID:10595
in subset: DO FlyBase slim
in subset: NCIthesaurus

Hartnup disease
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that is caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.
imported from: doid.owl
has cross-reference: GARD:6569
has cross-reference: ICD10CM:E72.02
has cross-reference: MESH:D006250
has cross-reference: NCI:C84748
has cross-reference: OMIM:234500
has cross-reference: SNOMEDCT_US_2020_03_01:80902009
has cross-reference: UMLS_CUI:C0018609
alternative_term: Neutral 1 amino acid transport defect
alternative_term: deficiency of tryptophan oxygenase
alternative_term: neutral amino acid transport defect
has_obo_namespace: disease_ontology
id: DOID:1060
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chronic tic disorder
type: Class
subclass of: tic disorder
textual definition: A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.
imported from: doid.owl
has cross-reference: ICD10CM:F95.1
has cross-reference: ICD9CM:307.22
has cross-reference: MESH:D013981
has cross-reference: NCI:C116768
has cross-reference: SNOMEDCT_US_2020_03_01:192623005
has cross-reference: UMLS_CUI:C0008701
alternative_term: chronic motor or vocal tic disorder
has_obo_namespace: disease_ontology
id: DOID:10600
in subset: NCIthesaurus

glucose intolerance
type: Class
subclass of: hyperglycemia
imported from: doid.owl
has cross-reference: ICD10CM:R73.03
has cross-reference: MESH:D018149
has cross-reference: NCI:C34646
has cross-reference: SNOMEDCT_US_2020_03_01:267426009
has cross-reference: UMLS_CUI:C0271650
alternative_term: Glucose: intolerance
alternative_term: Glucose: malabsorption
alternative_term: Malabsorption of glucose
has_obo_namespace: disease_ontology
id: DOID:10603
in subset: NCIthesaurus

lactose intolerance
type: Class
subclass of: carbohydrate metabolic disorder
imported from: doid.owl
has cross-reference: ICD10CM:E73
has cross-reference: MESH:D007787
has cross-reference: NCI:C3154
has cross-reference: OMIM:223100
has cross-reference: SNOMEDCT_US_2020_03_01:267497007
has cross-reference: UMLS_CUI:C0022951
alternative_term: LM - Lactose malabsorption
has_obo_namespace: disease_ontology
id: DOID:10604
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

short bowel syndrome
type: Class
subclass of: intestinal disease
textual definition: An intestinal disease that is characterized by a reduced ability to absorb nutrients due to the physical loss or the loss of function of a portion of the small and/or large intestine.
imported from: doid.owl
has cross-reference: MESH:D012778
has cross-reference: NCI:C99059
has cross-reference: SNOMEDCT_US_2020_03_01:204768009
has cross-reference: UMLS_CUI:C0036992
alternative_term: acquired short bowel syndrome
alternative_term: short gut syndrome
has_obo_namespace: disease_ontology
id: DOID:10605
in subset: NCIthesaurus

blind loop syndrome
type: Class
subclass of: intestinal disease
textual definition: An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption.
imported from: doid.owl
has cross-reference: ICD10CM:K90.2
has cross-reference: ICD9CM:579.2
has cross-reference: MESH:D001765
has cross-reference: NCI:C34431
has cross-reference: SNOMEDCT_US_2020_03_01:77225009
has cross-reference: UMLS_CUI:C0005750
alternative_term: Bacterial overgrowth syndrome
alternative_term: Blind loop syndrome
has_obo_namespace: disease_ontology
id: DOID:10606
in subset: NCIthesaurus

tropical sprue
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: GARD:7824
has cross-reference: ICD10CM:K90.1
has cross-reference: ICD9CM:579.1
has cross-reference: MESH:D013182
has cross-reference: NCI:C45428
has cross-reference: SNOMEDCT_US_2020_03_01:155846005
has cross-reference: UMLS_CUI:C0038054
alternative_term: Sprue - tropical
alternative_term: Tropical steatorrhea
has_obo_namespace: disease_ontology
id: DOID:10607
in subset: NCIthesaurus

celiac disease
type: Class
subclass of: autoimmune disease of gastrointestinal tract
textual definition: An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.
imported from: doid.owl
has cross-reference: EFO:0001060
has cross-reference: GARD:11998
has cross-reference: ICD10CM:K90.0
has cross-reference: ICD9CM:579.0
has cross-reference: MESH:D002446
has cross-reference: NCI:C26714
has cross-reference: OMIM:607202
has cross-reference: OMIM:609754
has cross-reference: OMIM:611598
has cross-reference: OMIM:612005
has cross-reference: OMIM:612006
has cross-reference: OMIM:612007
has cross-reference: OMIM:612008
has cross-reference: OMIM:612009
has cross-reference: OMIM:612011
has cross-reference: ORDO:555
has cross-reference: SNOMEDCT_US_2020_03_01:197477005
has cross-reference: UMLS_CUI:C0007570
alternative_term: celiac sprue
alternative_term: coeliac disease
alternative_term: idiopathic steatorrhea
has_obo_namespace: disease_ontology
id: DOID:10608
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

rickets
type: Class
subclass of: bone remodeling disease
textual definition: A bone remodeling disease that has_material_basis_in impaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone.
imported from: doid.owl
has_alternative_id: DOID:11672
has cross-reference: GARD:5700
has cross-reference: ICD10CM:E55.0
has cross-reference: ICD9CM:268.0
has cross-reference: MESH:D012279
has cross-reference: NCI:C26878
has cross-reference: OMIM:264700
has cross-reference: OMIM:277440
has cross-reference: OMIM:600081
has cross-reference: OMIM:600785
has cross-reference: ORDO:289157
has cross-reference: SNOMEDCT_US_2020_03_01:190639009
has cross-reference: SNOMEDCT_US_2020_03_01:68295002
has cross-reference: UMLS_CUI:C0035579
has cross-reference: UMLS_CUI:C0221468
alternative_term: active rickets
alternative_term: vitamin D hydroxylation-deficient rickets
alternative_term: vitamin D-dependent rickets
has_obo_namespace: disease_ontology
id: DOID:10609
in subset: NCIthesaurus
comment: Xref MGI.

pancreatic steatorrhea
type: Class
subclass of: pancreas disease
imported from: doid.owl
has cross-reference: ICD10CM:K90.3
has cross-reference: ICD9CM:579.4
has cross-reference: SNOMEDCT_US_2020_03_01:155845009
has cross-reference: UMLS_CUI:C0152166
alternative_term: pancreatic steatorrhoea
has_obo_namespace: disease_ontology
id: DOID:10610

protein-losing enteropathy
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: MESH:D011504
has cross-reference: OMIM:226300
has cross-reference: SNOMEDCT_US_2020_03_01:66972006
has cross-reference: UMLS_CUI:C0033680
alternative_term: Enteropathy, exudative
alternative_term: Exudative enteropathy
alternative_term: Protein-losing enteropathy
has_obo_namespace: disease_ontology
id: DOID:10611
comment: OMIM mapping confirmed by DO. [SN].

allergic urticaria
type: Class
subclass of: allergic disease
subclass of: urticaria
textual definition: An urticaria that is characterized by erythematous papules and plaques, has_symptom pruritis, and has_material_basis_in allergic reaction.
imported from: doid.owl
has cross-reference: ICD10CM:L50.0
has cross-reference: ICD9CM:708.0
has cross-reference: SNOMEDCT_US_2020_03_01:201260002
has cross-reference: UMLS_CUI:C0149526
alternative_term: Allergic urticaria
has_obo_namespace: disease_ontology
id: DOID:10612

Fanconi syndrome
type: Class
subclass of: renal tubular transport disease
textual definition: A renal tubular transport disease of the proximal renal tubes characterized by glucosuria, phosphaturia, generalized aminoaciduria and HCO3 wasting.
imported from: doid.owl
has_alternative_id: DOID:5956
has cross-reference: GARD:9118
has cross-reference: MESH:D005198
has cross-reference: NCI:C3034
has cross-reference: NCI:C4377
has cross-reference: OMIM:PS134600
has cross-reference: ORDO:3337
has cross-reference: SNOMEDCT_US_2020_03_01:236468006
has cross-reference: SNOMEDCT_US_2020_03_01:40488004
has cross-reference: UMLS_CUI:C0015624
has cross-reference: UMLS_CUI:C0341703
alternative_term: Congenital Fanconi syndrome
alternative_term: De Toni-Fanconi syndrome
alternative_term: Fanconi-de Toni syndrome
alternative_term: Fanconi-de-Toni syndrome
alternative_term: Infantile nephropathic cystinosis
alternative_term: Lignac-Fanconi syndrome
alternative_term: adult Fanconi Anemia
alternative_term: adult Fanconi syndrome
alternative_term: deToni Fanconi syndrome
has_obo_namespace: disease_ontology
id: DOID:1062
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

microphthalmia
type: Class
subclass of: eye disease
textual definition: An eye disease where one or both eyeballs are abnormally small.
imported from: doid.owl
has_alternative_id: DOID:10650
has cross-reference: GARD:12085
has cross-reference: ICD10CM:Q11.2
has cross-reference: ICD9CM:743.1
has cross-reference: MESH:D008850
has cross-reference: NCI:C98989
has cross-reference: SNOMEDCT_US_2020_03_01:156902006
has cross-reference: UMLS_CUI:C0026010
alternative_term: microphthalmos
alternative_term: simple microphthalmos
has_obo_namespace: disease_ontology
id: DOID:10629
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

interstitial nephritis
type: Class
subclass of: nephritis
imported from: doid.owl
has cross-reference: ICD10CM:N12
has cross-reference: MESH:D009395
has cross-reference: NCI:C26834
has cross-reference: SNOMEDCT_US_2020_03_01:28689008
has cross-reference: UMLS_CUI:C0027707
alternative_term: renal tubulo-interstitial disease
has_obo_namespace: disease_ontology
id: DOID:1063
in subset: NCIthesaurus

Wolfram syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by diabetes mellitus, optic atrophy, and deafness.
imported from: doid.owl
has cross-reference: GARD:7898
has cross-reference: MESH:D014929
has cross-reference: NCI:C35133
has cross-reference: ORDO:3463
has cross-reference: SNOMEDCT_US_2020_03_01:70694009
has cross-reference: UMLS_CUI:C0043207
has_obo_namespace: disease_ontology
id: DOID:10632
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

cystinosis
type: Class
subclass of: autosomal recessive disease
subclass of: lysosomal storage disease
textual definition: A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and that has_material_basis_in mutations in the CTNS gene, located on chromosome 17.
imported from: doid.owl
has cross-reference: GARD:6236
has cross-reference: MESH:D003554
has cross-reference: NCI:C129932
has cross-reference: OMIM:219750
has cross-reference: OMIM:219800
has cross-reference: OMIM:219900
has cross-reference: ORDO:213
has cross-reference: SNOMEDCT_US_2020_03_01:62332007
has cross-reference: UMLS_CUI:C2931187
alternative_term: cystine storage disease
has_obo_namespace: disease_ontology
id: DOID:1064
in subset: DO rare slim
in subset: NCIthesaurus

schizotypal personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs.
imported from: doid.owl
has cross-reference: ICD10CM:F21
has cross-reference: ICD9CM:301.22
has cross-reference: MESH:D012569
has cross-reference: NCI:C92632
has cross-reference: SNOMEDCT_US_2020_03_01:231486008
has cross-reference: UMLS_CUI:C0036363
has_obo_namespace: disease_ontology
id: DOID:10646
in subset: NCIthesaurus

Alzheimer's disease
type: Class
subclass of: tauopathy
textual definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
imported from: doid.owl
has cross-reference: EFO:0000249
has cross-reference: GARD:10254
has cross-reference: ICD10CM:G30
has cross-reference: ICD9CM:331.0
has cross-reference: KEGG:05010
has cross-reference: MESH:D000544
has cross-reference: NCI:C2866
has cross-reference: SNOMEDCT_US_2020_03_01:73768007
has cross-reference: UMLS_CUI:C0002395
alternative_term: Alzheimer disease
alternative_term: Alzheimers dementia
has_obo_namespace: disease_ontology
id: DOID:10652
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

lipoma of colon
type: Class
subclass of: colonic disease
subclass of: large intestine lipoma
imported from: doid.owl
has cross-reference: NCI:C5493
has cross-reference: UMLS_CUI:C0940607
alternative_term: Colonic Lipoma
has_obo_namespace: disease_ontology
id: DOID:10655
in subset: NCIthesaurus

open-angle glaucoma
type: Class
subclass of: glaucoma
textual definition: A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.
imported from: doid.owl
has cross-reference: EFO:0004190
has cross-reference: ICD10CM:H40.1
has cross-reference: ICD9CM:365.1
has cross-reference: MESH:D005902
has cross-reference: NCI:C34641
has cross-reference: OMIM:137750
has cross-reference: OMIM:177700
has cross-reference: OMIM:602429
has cross-reference: OMIM:603383
has cross-reference: OMIM:606689
has cross-reference: OMIM:608695
has cross-reference: OMIM:608696
has cross-reference: OMIM:609745
has cross-reference: OMIM:609887
has cross-reference: OMIM:610535
has cross-reference: OMIM:611274
has cross-reference: OMIM:611276
has cross-reference: OMIM:613100
has cross-reference: SNOMEDCT_US_2020_03_01:84494001
has cross-reference: UMLS_CUI:C0017612
alternative_term: Wide-angle glaucoma
alternative_term: glaucoma simplex
alternative_term: open angle glaucoma
alternative_term: pigmentary glaucoma
has_obo_namespace: disease_ontology
id: DOID:1067
in subset: NCIthesaurus
comment: Xref MGI.

mastitis
type: Class
subclass of: breast disease
textual definition: A breast disease characterized by painful infection of the breast tissue.
imported from: doid.owl
has cross-reference: MESH:D008413
has cross-reference: NCI:C53662
has cross-reference: SNOMEDCT_US_2020_03_01:155952005
has cross-reference: UMLS_CUI:C0024894
alternative_term: Inflammatory breast disease
alternative_term: Inflammatory disease of breast
alternative_term: breast inflammation
has_obo_namespace: disease_ontology
id: DOID:10690
in subset: NCIthesaurus

chronic endophthalmitis
type: Class
subclass of: DOID 9724
imported from: doid.owl
has cross-reference: ICD9CM:360.03
has cross-reference: SNOMEDCT_US_2020_03_01:193269007
has cross-reference: UMLS_CUI:C0154774
has_obo_namespace: disease_ontology
id: DOID:10697

paragonimiasis
type: Class
subclass of: splenic disease
subclass of: liver disease
subclass of: DOID 883
subclass of: DOID 936
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection by flukes of the genus Paragonimus. In the acute phase, the symptoms are diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. Pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Various organs like brain, spleen and liver can be infected.
imported from: doid.owl
has cross-reference: GARD:9815
has cross-reference: ICD10CM:B66.4
has cross-reference: ICD9CM:121.2
has cross-reference: MESH:D010237
has cross-reference: NCI:C84995
has cross-reference: SNOMEDCT_US_2020_03_01:30369007
has cross-reference: UMLS_CUI:C0030424
alternative_term: Infection by Paragonimus
alternative_term: lung fluke disease
alternative_term: lung fluke infection
alternative_term: pulmonary paragonimiasis
has_obo_namespace: disease_ontology
id: DOID:10699
in subset: NCIthesaurus

primary open angle glaucoma
type: Class
subclass of: open-angle glaucoma
textual definition: An open-angle glaucoma that is characterized by the absence of any apparent obstruction of aqueous outflow through the trabecular meshwork with gonioscopy, but often with elevated intraocular pressure.
imported from: doid.owl
has cross-reference: ICD10CM:H40.11
has cross-reference: ICD9CM:365.11
has cross-reference: MESH:D005902
has cross-reference: NCI:C35394
has cross-reference: OMIM:137760
has cross-reference: SNOMEDCT_US_2020_03_01:77075001
has cross-reference: UMLS_CUI:C0339573
alternative_term: chronic simple glaucoma
has_obo_namespace: disease_ontology
id: DOID:1070
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

giardiasis
type: Class
subclass of: parasitic protozoa infectious disease
textual definition: A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.
imported from: doid.owl
has cross-reference: ICD10CM:A07.1
has cross-reference: ICD9CM:007.1
has cross-reference: MESH:D005873
has cross-reference: SNOMEDCT_US_2020_03_01:266176008
has cross-reference: UMLS_CUI:C0017536
alternative_term: Infection by Giardia lamblia
alternative_term: beaver feaver
has_obo_namespace: disease_ontology
id: DOID:10718

toxic diffuse goiter
type: Class
subclass of: hyperthyroidism
imported from: doid.owl
has cross-reference: GARD:6549
has cross-reference: ICD9CM:242.00
has cross-reference: UMLS_CUI:C0154138
has_obo_namespace: disease_ontology
id: DOID:10719

kidney failure
type: Class
subclass of: kidney disease
textual definition: A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood.
imported from: doid.owl
has cross-reference: ICD10CM:N19
has cross-reference: ICD9CM:586
has cross-reference: MESH:D051437
has cross-reference: NCI:C4376
has cross-reference: SNOMEDCT_US_2020_03_01:42399005
has cross-reference: UMLS_CUI:C0035078
alternative_term: renal failure
has_obo_namespace: disease_ontology
id: DOID:1074
in subset: NCIthesaurus
comment: PRISM.

cerebral lipidosis
type: Class
subclass of: cerebral degeneration
imported from: doid.owl
has cross-reference: ICD9CM:330.1
has cross-reference: SNOMEDCT_US_2020_03_01:16517004
has cross-reference: UMLS_CUI:C0007788
has_obo_namespace: disease_ontology
id: DOID:10742

otitis media
type: Class
subclass of: middle ear disease
textual definition: A otitis which involves inflammation of the middle ear.
imported from: doid.owl
has cross-reference: ICD10CM:H66.9
has cross-reference: ICD9CM:382.9
has cross-reference: MESH:D010033
has cross-reference: NCI:C34885
has cross-reference: SNOMEDCT_US_2020_03_01:65363002
has cross-reference: UMLS_CUI:C0029882
has_obo_namespace: disease_ontology
id: DOID:10754
in subset: NCIthesaurus

chronic pyelonephritis
type: Class
subclass of: pyelonephritis
imported from: doid.owl
has cross-reference: ICD10CM:N11
has cross-reference: ICD9CM:590.0
has cross-reference: NCI:C123216
has cross-reference: SNOMEDCT_US_2020_03_01:123293005
has cross-reference: UMLS_CUI:C0085697
has_obo_namespace: disease_ontology
id: DOID:1076
in subset: NCIthesaurus

portal hypertension
type: Class
subclass of: hepatic vascular disease
imported from: doid.owl
has cross-reference: GARD:8229
has cross-reference: ICD10CM:K76.6
has cross-reference: ICD9CM:572.3
has cross-reference: MESH:D006975
has cross-reference: NCI:C3119
has cross-reference: SNOMEDCT_US_2020_03_01:155821005
has cross-reference: UMLS_CUI:C0020541
has_obo_namespace: disease_ontology
id: DOID:10762
in subset: NCIthesaurus

hypertension
type: Class
subclass of: artery disease
textual definition: An artery disease characterized by chronic elevated blood pressure in the arteries.
imported from: doid.owl
has cross-reference: EFO:0000537
has cross-reference: ICD10CM:I10
has cross-reference: ICD9CM:401-405.99
has cross-reference: MESH:D006973
has cross-reference: NCI:C3117
has cross-reference: SNOMEDCT_US_2020_03_01:38341003
has cross-reference: UMLS_CUI:C0020538
alternative_term: HTN
alternative_term: High blood pressure
alternative_term: hyperpiesia
alternative_term: vascular hypertensive disorder
has_obo_namespace: disease_ontology
has_related_synonym: hypertensive disease
id: DOID:10763
in subset: NCIthesaurus

thrombotic thrombocytopenic purpura
type: Class
subclass of: thrombophilia
imported from: doid.owl
has cross-reference: GARD:9430
has cross-reference: ICD10CM:M31.1
has cross-reference: MESH:D011697
has cross-reference: NCI:C78797
has cross-reference: OMIM:274150
has cross-reference: SNOMEDCT_US_2020_03_01:360402008
has cross-reference: UMLS_CUI:C0034155
alternative_term: Moschcowitz's syndrome
has_obo_namespace: disease_ontology
id: DOID:10772
in subset: NCIthesaurus

fiedler's myocarditis
type: Class
subclass of: acute myocarditis
imported from: doid.owl
has cross-reference: ICD10CM:I40.1
has cross-reference: ICD9CM:422.91
has cross-reference: SNOMEDCT_US_2020_03_01:194954007
has cross-reference: UMLS_CUI:C0155689
alternative_term: Idiopathic myocarditis
alternative_term: Isolated (Fiedler's) myocarditis
alternative_term: fiedler myocarditis
has_obo_namespace: disease_ontology
id: DOID:10778

methemoglobinemia
type: Class
subclass of: hemoglobinopathy
imported from: doid.owl
has cross-reference: ICD10CM:D74
has cross-reference: ICD9CM:289.7
has cross-reference: MESH:D008708
has cross-reference: NCI:C34817
has cross-reference: SNOMEDCT_US_2020_03_01:191386007
has cross-reference: UMLS_CUI:C0025637
has_obo_namespace: disease_ontology
id: DOID:10783
in subset: NCIthesaurus

Queensland tick typhus
type: Class
subclass of: spotted fever
textual definition: A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy.
imported from: doid.owl
has_alternative_id: DOID:0050038
alternative_term: Australian tick typhus
alternative_term: Rickettsia australis spotted fever
has_obo_namespace: disease_ontology
has_related_synonym: North Queensland tick typhus
id: DOID:10784
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

frontal sinusitis
type: Class
subclass of: sinusitis
textual definition: A sinusitis which involves infection of the frontal sinuses over the eyes in the brow area. This causes pain or pressure in the frontal sinus cavity and headache over the forehead.
imported from: doid.owl
has cross-reference: ICD10CM:J32.1
has cross-reference: MESH:D015522
has cross-reference: NCI:C34626
has cross-reference: SNOMEDCT_US_2020_03_01:275485006
has cross-reference: UMLS_CUI:C0016735
has_obo_namespace: disease_ontology
id: DOID:10791
in subset: NCIthesaurus

chronic maxillary sinusitis
type: Class
subclass of: maxillary sinusitis
textual definition: A maxillary sinusitis which lasts for 12 weeks or more.
imported from: doid.owl
has cross-reference: ICD10CM:J32.0
has cross-reference: ICD9CM:473.0
has cross-reference: NCI:C34477
has cross-reference: SNOMEDCT_US_2020_03_01:195785003
has cross-reference: UMLS_CUI:C0008698
alternative_term: chronic antritis
has_obo_namespace: disease_ontology
id: DOID:10792
in subset: NCIthesaurus

sphenoid sinusitis
type: Class
subclass of: sinusitis
textual definition: A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head.
imported from: doid.owl
has cross-reference: ICD10CM:J32.3
has cross-reference: MESH:D015524
has cross-reference: NCI:C35031
has cross-reference: SNOMEDCT_US_2020_03_01:13266007
has cross-reference: UMLS_CUI:C0037886
alternative_term: Sphenoidal sinusitis
has_obo_namespace: disease_ontology
id: DOID:10794
in subset: NCIthesaurus

filariasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.
imported from: doid.owl
has cross-reference: ICD10CM:B74
has cross-reference: ICD9CM:125.9
has cross-reference: MESH:D005368
has cross-reference: NCI:C34611
has cross-reference: SNOMEDCT_US_2020_03_01:50342004
has cross-reference: UMLS_CUI:C0016085
alternative_term: disease due to superfamily Filarioidea
has_obo_namespace: disease_ontology
id: DOID:1080
in subset: NCIthesaurus

nasal cavity cancer
type: Class
subclass of: respiratory system cancer
subclass of: nasal cavity disease
textual definition: A respiratory system cancer that is located_in the nasal cavity.
imported from: doid.owl
has cross-reference: ICD10CM:C30.0
has cross-reference: ICD9CM:160.0
has cross-reference: NCI:C4918
has cross-reference: SNOMEDCT_US_2020_03_01:93917007
has cross-reference: UMLS_CUI:C0728864
alternative_term: malignant neoplasm of nasal cavities
alternative_term: malignant tumor of the nasal cavity
has_obo_namespace: disease_ontology
id: DOID:10811
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

nasal cavity lymphoma
type: Class
subclass of: lymphoma
subclass of: nasal cavity cancer
imported from: doid.owl
has cross-reference: NCI:C6074
has cross-reference: UMLS_CUI:C1334921
alternative_term: Lymphoma of the nasal cavity
alternative_term: lymphoma of nasal cavity
has_obo_namespace: disease_ontology
id: DOID:10813
in subset: NCIthesaurus

duodenum adenocarcinoma
type: Class
subclass of: duodenum cancer
subclass of: adenocarcinoma
textual definition: A duodenum cancer that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C7889
has cross-reference: SNOMEDCT_US_2020_03_01:408644002
has cross-reference: UMLS_CUI:C0278804
alternative_term: Duodenal adenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:10816
in subset: NCIthesaurus

dirofilariasis
type: Class
subclass of: filariasis
subclass of: skin disease
subclass of: lung disease
textual definition: A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.
imported from: doid.owl
has cross-reference: GARD:11908
has cross-reference: ICD10CM:B74.8
has cross-reference: MESH:D004184
has cross-reference: SNOMEDCT_US_2020_03_01:73328005
has cross-reference: UMLS_CUI:C0012602
alternative_term: Dirofilaria infectious disease
alternative_term: Infection by Dirofilaria
has_obo_namespace: disease_ontology
id: DOID:1082
in subset: zoonotic infectious disease

voyeurism
type: Class
subclass of: paraphilia disorder
imported from: doid.owl
has cross-reference: ICD10CM:F65.3
has cross-reference: ICD9CM:302.82
has cross-reference: MESH:D014843
has cross-reference: NCI:C94360
has cross-reference: SNOMEDCT_US_2020_03_01:192515002
has cross-reference: UMLS_CUI:C0042979
has_obo_namespace: disease_ontology
id: DOID:10834
in subset: NCIthesaurus

Eastern equine encephalitis
type: Class
subclass of: DOID 934
subclass of: DOID 936
textual definition: A viral infectious disease that results in inflammation located in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted by Aedes, transmitted by Coquillettidia, and transmitted by Culex species of mosquitoes. The infection has symptom sudden onset of headache, has symptom high fever, has symptom chills, has symptom vomiting, has symptom disorientation, has symptom seizures, and has symptom coma.
imported from: doid.owl
has cross-reference: GARD:10821
has cross-reference: ICD10CM:A83.2
has cross-reference: ICD9CM:062.2
has cross-reference: MESH:D020242
has cross-reference: SNOMEDCT_US_2020_03_01:40177004
has cross-reference: UMLS_CUI:C0153065
alternative_term: Neuroinvasive Eastern equine encephalitis virus infection
has_obo_namespace: disease_ontology
has_related_synonym: EEE
id: DOID:10841
in subset: zoonotic infectious disease

Murray Valley encephalitis
type: Class
subclass of: DOID 934
subclass of: DOID 936
textual definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.
imported from: doid.owl
has cross-reference: ICD10CM:A83.4
has cross-reference: ICD9CM:062.4
has cross-reference: SNOMEDCT_US_2020_03_01:66454007
has cross-reference: UMLS_CUI:C0153066
alternative_term: Australian X disease
alternative_term: Australian encephalitis
has_obo_namespace: disease_ontology
id: DOID:10842

Western equine encephalitis
type: Class
subclass of: DOID 934
subclass of: DOID 936
textual definition: A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.
imported from: doid.owl
has cross-reference: GARD:7888
has cross-reference: ICD10CM:A83.1
has cross-reference: ICD9CM:062.1
has cross-reference: MESH:D020241
has cross-reference: NCI:C85227
has cross-reference: SNOMEDCT_US_2020_03_01:47523006
has cross-reference: UMLS_CUI:C0153064
has_obo_namespace: disease_ontology
has_related_synonym: WEE
id: DOID:10843
in subset: NCIthesaurus
in subset: zoonotic infectious disease

Japanese encephalitis
type: Class
subclass of: DOID 934
subclass of: DOID 936
textual definition: A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.
imported from: doid.owl
has cross-reference: GARD:6797
has cross-reference: ICD10CM:A83.0
has cross-reference: ICD9CM:062.0
has cross-reference: MESH:D004672
has cross-reference: NCI:C34577
has cross-reference: SNOMEDCT_US_2020_03_01:266194002
has cross-reference: UMLS_CUI:C0014057
alternative_term: Japanese B encephalitis
has_obo_namespace: disease_ontology
id: DOID:10844
in subset: NCIthesaurus

St. Louis encephalitis
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.
imported from: doid.owl
has cross-reference: ICD10CM:A83.3
has cross-reference: ICD9CM:062.3
has cross-reference: MESH:D004674
has cross-reference: SNOMEDCT_US_2020_03_01:10429004
has cross-reference: UMLS_CUI:C0014060
alternative_term: Neuroinvasive St. Louis encephalitis virus infection
has_obo_namespace: disease_ontology
id: DOID:10845

Edwards syndrome
type: Class
subclass of: chromosomal duplication syndrome
textual definition: A chromosomal duplciation syndrome that is characterized by slow growth before birth and a low birth weight and that has_material_basis_in three copies of chromosome 18.
imported from: doid.owl
has cross-reference: ICD9CM:758.2
has cross-reference: MESH:D000073842
has cross-reference: NCI:C101362
has cross-reference: SNOMEDCT_US_2020_03_01:51500006
has cross-reference: UMLS_CUI:C0152096
alternative_term: Complete trisomy 18 syndrome
alternative_term: E3 Trisomy
alternative_term: trisomy 18
has_obo_namespace: disease_ontology
id: DOID:1085
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

salivary gland disease
type: Class
subclass of: mouth disease
textual definition: A mouth disease located_in the salivary gland.
imported from: doid.owl
has_alternative_id: DOID:12898
has cross-reference: ICD9CM:527.8
has cross-reference: UMLS_CUI:C0029773
alternative_term: Non-neoplastic Salivary gland disease
alternative_term: Salivary gland disease
has_obo_namespace: disease_ontology
id: DOID:10854

paralytic squint
type: Class
subclass of: strabismus
imported from: doid.owl
has cross-reference: ICD10CM:H49
has cross-reference: ICD9CM:378.5
has cross-reference: SNOMEDCT_US_2020_03_01:12942001
has cross-reference: UMLS_CUI:C0152221
alternative_term: Incomitant dissociation
alternative_term: Paralytic strabismus
has_obo_namespace: disease_ontology
id: DOID:10863

age related macular degeneration
type: Class
subclass of: autosomal dominant disease
subclass of: degeneration of macula and posterior pole
textual definition: A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.
imported from: doid.owl
has cross-reference: EFO:0001365
has cross-reference: ICD10CM:H35.30
has cross-reference: ICD9CM:362.50
has cross-reference: MESH:D008268
has cross-reference: NCI:C84391
has cross-reference: OMIM:PS603075
has cross-reference: SNOMEDCT_US_2020_03_01:18222007
has cross-reference: UMLS_CUI:C0242383
alternative_term: Age Related Maculopathies
alternative_term: Age Related Maculopathy
alternative_term: Senile macular degeneration
alternative_term: Senile macular retinal degeneration
alternative_term: age-related macular degeneration
has_obo_namespace: disease_ontology
id: DOID:10871
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Kuhnt-Junius degeneration
type: Class
subclass of: degeneration of macula and posterior pole
imported from: doid.owl
has cross-reference: ICD10CM:H35.32
has cross-reference: ICD9CM:362.52
has cross-reference: SNOMEDCT_US_2020_03_01:11290001
has cross-reference: UMLS_CUI:C0271084
alternative_term: Exudative senile macular degeneration of retina
alternative_term: Neovascular age-related macular degeneration
alternative_term: Senile macular degeneration, wet
alternative_term: Wet senile macular retinal degeneration
has_obo_namespace: disease_ontology
id: DOID:10873

meningocele
type: Class
subclass of: spina bifida
textual definition: A spina bifida that is characterized by herniation of the meninges between the vertebrae.
imported from: doid.owl
has cross-reference: SNOMEDCT_US_2020_03_01:268308005
has cross-reference: UMLS_CUI:C0025299
has_obo_namespace: disease_ontology
id: DOID:1088

hand, foot and mouth disease
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.
imported from: doid.owl
has cross-reference: ICD10CM:B08.4
has cross-reference: ICD9CM:074.3
has cross-reference: MESH:D006232
has cross-reference: NCI:C128439
has cross-reference: SNOMEDCT_US_2020_03_01:175497008
has cross-reference: UMLS_CUI:C0018572
alternative_term: Vesicular stomatitis and exanthem
has_obo_namespace: disease_ontology
id: DOID:10881
in subset: NCIthesaurus

epidemic pleurodynia
type: Class
subclass of: muscular disease
subclass of: DOID 934
textual definition: A viral infectious disease that results in necrosis located in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has symptom severe chest pain, has symptom fever, has symptom malaise, has symptom pleuritis, and has symptom headache.
imported from: doid.owl
has cross-reference: ICD10CM:B33.0
has cross-reference: ICD9CM:074.1
has cross-reference: MESH:D011000
has cross-reference: SNOMEDCT_US_2020_03_01:83264000
has cross-reference: UMLS_CUI:C0032238
alternative_term: Bamble disease
alternative_term: Bornholm disease
alternative_term: Epidemic pleurisy
alternative_term: Epidemic, myositis
alternative_term: devil's grip
alternative_term: epidemic myalgia
has_obo_namespace: disease_ontology
id: DOID:10882

herpangina
type: Class
subclass of: mouth disease
subclass of: DOID 934
textual definition: A viral infectious disease that results in infection located in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.
imported from: doid.owl
has cross-reference: ICD10CM:B08.5
has cross-reference: ICD9CM:074.0
has cross-reference: MESH:D006557
has cross-reference: SNOMEDCT_US_2020_03_01:154358007
has cross-reference: UMLS_CUI:C0019338
alternative_term: Vesicular pharyngitis
has_obo_namespace: disease_ontology
id: DOID:10883

tethered spinal cord syndrome
type: Class
subclass of: spinal cord disease
imported from: doid.owl
has cross-reference: GARD:4018
has cross-reference: SNOMEDCT_US_2020_03_01:282784007
has cross-reference: UMLS_CUI:C0560648
alternative_term: spinal dysraphism
has_obo_namespace: disease_ontology
id: DOID:1089
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

hypospadias
type: Class
subclass of: physical disorder
textual definition: A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum.
imported from: doid.owl
has cross-reference: ICD10CM:Q54
has cross-reference: MESH:D007021
has cross-reference: NCI:C40341
has cross-reference: OMIM:146450
has cross-reference: OMIM:300633
has cross-reference: OMIM:300758
has cross-reference: OMIM:300856
has cross-reference: ORDO:440
has cross-reference: SNOMEDCT_US_2020_03_01:156968008
has cross-reference: UMLS_CUI:C0848558
alternative_term: familial hypospadias
has_obo_namespace: disease_ontology
id: DOID:10892
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

microcephaly
type: Class
subclass of: congenital nervous system abnormality
textual definition: A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants.
imported from: doid.owl
has cross-reference: GARD:3603
has cross-reference: GARD:7038
has cross-reference: ICD10CM:Q02
has cross-reference: ICD9CM:742.1
has cross-reference: MESH:D008831
has cross-reference: NCI:C85874
has cross-reference: SNOMEDCT_US_2020_03_01:156893009
has cross-reference: UMLS_CUI:C0025958
alternative_term: Microcephalus
alternative_term: microencephaly
has_obo_namespace: disease_ontology
id: DOID:10907
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hydrocephalus
type: Class
subclass of: cerebral degeneration
textual definition: A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head.
imported from: doid.owl
has cross-reference: GARD:6682
has cross-reference: ICD10CM:G91
has cross-reference: MESH:D006849
has cross-reference: NCI:C3111
has cross-reference: OMIM:123155
has cross-reference: OMIM:236600
has cross-reference: OMIM:236635
has cross-reference: OMIM:307000
has cross-reference: OMIM:615219
has cross-reference: ORDO:2182
has cross-reference: ORDO:2185
has cross-reference: SNOMEDCT_US_2020_03_01:267687006
has cross-reference: UMLS_CUI:C0020255
alternative_term: hydrocephalus, X-linked
alternative_term: hydrocephalus, nonsyndromic, autosomal recessive
has_obo_namespace: disease_ontology
id: DOID:10908
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

tooth disease
type: Class
subclass of: mouth disease
textual definition: A mouth disease located_in the teeth.
imported from: doid.owl
has cross-reference: MESH:D014076
has cross-reference: SNOMEDCT_US_2020_03_01:72722003
has cross-reference: UMLS_CUI:C0040435
alternative_term: teeth disease
has_obo_namespace: disease_ontology
id: DOID:1091

amnestic disorder
type: Class
subclass of: cognitive disorder
textual definition: A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.
imported from: doid.owl
has_alternative_id: DOID:4544
has cross-reference: ICD10CM:R41.3
has cross-reference: ICD9CM:294.0
has cross-reference: MESH:D000647
has cross-reference: NCI:C2867
has cross-reference: SNOMEDCT_US_2020_03_01:247606008
has cross-reference: SNOMEDCT_US_2020_03_01:3298001
has cross-reference: UMLS_CUI:C0002622
has cross-reference: UMLS_CUI:C0002625
alternative_term: Amnestic syndrome
alternative_term: Korsakoff's psychosis or syndrome
alternative_term: amnesia
has_obo_namespace: disease_ontology
id: DOID:10914
in subset: DO FlyBase slim
in subset: NCIthesaurus

Wernicke-Korsakoff syndrome
type: Class
subclass of: thiamine deficiency disease
textual definition: A nutritional deficiency disease that is characterized by ophthalmoplegia, ataxia, change in mental status and acute onset of severe memory impairment without any dysfunction in intellectual abilities, and has_material_basis_in thiamine deficiency.
imported from: doid.owl
has cross-reference: MESH:D020915
has cross-reference: NCI:C35764
has cross-reference: OMIM:277730
has cross-reference: SNOMEDCT_US_2020_03_01:69482004
has cross-reference: UMLS_CUI:C0349464
alternative_term: Korsakoff Syndrome
alternative_term: Korsakoff's psychosis
alternative_term: Korsakoff's syndrome
alternative_term: Korsakov psychosis
alternative_term: Korsakov's psychosis
has_obo_namespace: disease_ontology
id: DOID:10915
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

transsexualism
type: Class
subclass of: gender identity disorder
textual definition: A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.
imported from: doid.owl
has cross-reference: ICD9CM:302.50
has cross-reference: SNOMEDCT_US_2020_03_01:191782007
has cross-reference: UMLS_CUI:C0040630
has_obo_namespace: disease_ontology
id: DOID:10919

sickle cell anemia
type: Class
subclass of: autosomal recessive disease
subclass of: blood protein disease
textual definition: A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
imported from: doid.owl
has_alternative_id: DOID:12924
has_alternative_id: DOID:13024
has cross-reference: GARD:8614
has cross-reference: ICD10CM:D57.1
has cross-reference: ICD10CM:D57.2
has cross-reference: ICD9CM:282.6
has cross-reference: ICD9CM:282.63
has cross-reference: MESH:D000755
has cross-reference: MESH:D006450
has cross-reference: NCI:C34383
has cross-reference: NCI:C34676
has cross-reference: OMIM:603903
has cross-reference: ORDO:232
has cross-reference: SNOMEDCT_US_2020_03_01:154798006
has cross-reference: SNOMEDCT_US_2020_03_01:35434009
has cross-reference: UMLS_CUI:C0002895
has cross-reference: UMLS_CUI:C0019034
alternative_term: Hb SC disease
alternative_term: Hb-S/Hb-C disease
alternative_term: Hb-SS disease without crisis
alternative_term: Hemoglobin S disease without crisis
alternative_term: Sickle-cell/Hb-C disease without crisis
alternative_term: drepanocytosis
alternative_term: haemoglobin SC disease
alternative_term: hemoglobin SC disease
alternative_term: sickle cell anaemia
has_obo_namespace: disease_ontology
id: DOID:10923
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

borderline personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.
imported from: doid.owl
has cross-reference: ICD10CM:F60.3
has cross-reference: ICD9CM:301.83
has cross-reference: MESH:D001883
has cross-reference: NCI:C92633
has cross-reference: SNOMEDCT_US_2020_03_01:20010003
has cross-reference: UMLS_CUI:C0006012
has_obo_namespace: disease_ontology
id: DOID:10930
in subset: NCIthesaurus

dependent personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that is characterized by a pervasive psychological dependence on other people.
imported from: doid.owl
has cross-reference: ICD10CM:F60.7
has cross-reference: ICD9CM:301.6
has cross-reference: MESH:D003859
has cross-reference: NCI:C92637
has cross-reference: SNOMEDCT_US_2020_03_01:192492003
has cross-reference: UMLS_CUI:C0011548
has_obo_namespace: disease_ontology
id: DOID:10931
in subset: NCIthesaurus

obsessive-compulsive personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that is characterized by a pervasive pattern of preoccupation with orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency.
imported from: doid.owl
has cross-reference: ICD10CM:F60.5
has cross-reference: ICD9CM:301.4
has cross-reference: MESH:D003193
has cross-reference: NCI:C92638
has cross-reference: SNOMEDCT_US_2020_03_01:191761001
has cross-reference: UMLS_CUI:C0009595
alternative_term: OCPD
has_obo_namespace: disease_ontology
has_related_synonym: Anankastic personality disorder
id: DOID:10932
in subset: NCIthesaurus

multiple personality disorder
type: Class
subclass of: dissociative disorder
textual definition: A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities.
imported from: doid.owl
has cross-reference: ICD10CM:F44.81
has cross-reference: ICD9CM:300.14
has cross-reference: MESH:D009105
has cross-reference: NCI:C94330
has cross-reference: SNOMEDCT_US_2020_03_01:31611000
has cross-reference: UMLS_CUI:C0026773
alternative_term: Dissociative identity disorder
has_obo_namespace: disease_ontology
id: DOID:10934
in subset: NCIthesaurus

dissociative disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated).
imported from: doid.owl
has_alternative_id: DOID:4963
has cross-reference: ICD10CM:F44.9
has cross-reference: ICD10CM:F48.9
has cross-reference: ICD9CM:300.15
has cross-reference: ICD9CM:300.9
has cross-reference: MESH:D004213
has cross-reference: NCI:C92197
has cross-reference: SNOMEDCT_US_2020_03_01:154883004
has cross-reference: UMLS_CUI:C0012746
has cross-reference: UMLS_CUI:C0041857
alternative_term: dissociative disease
alternative_term: dissociative reaction
has_obo_namespace: disease_ontology
id: DOID:10935
in subset: NCIthesaurus

schizoid personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world.
imported from: doid.owl
has cross-reference: ICD10CM:F60.1
has cross-reference: ICD9CM:301.2
has cross-reference: MESH:D012557
has cross-reference: NCI:C92631
has cross-reference: SNOMEDCT_US_2020_03_01:192486009
has cross-reference: UMLS_CUI:C0036339
has_obo_namespace: disease_ontology
id: DOID:10936
in subset: NCIthesaurus

impulse control disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.
imported from: doid.owl
has cross-reference: ICD10CM:F63.9
has cross-reference: ICD9CM:312.30
has cross-reference: MESH:D007174
has cross-reference: NCI:C34723
has cross-reference: SNOMEDCT_US_2020_03_01:192098008
has cross-reference: UMLS_CUI:C0021122
has_obo_namespace: disease_ontology
id: DOID:10937
in subset: NCIthesaurus

paranoid personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that is characterized by paranoia and a pervasive, long-standing suspiciousness and generalized mistrust of others.
imported from: doid.owl
has cross-reference: ICD10CM:F60.0
has cross-reference: ICD9CM:301.0
has cross-reference: MESH:D010260
has cross-reference: NCI:C92630
has cross-reference: SNOMEDCT_US_2020_03_01:270529002
has cross-reference: UMLS_CUI:C0030477
has_obo_namespace: disease_ontology
id: DOID:10938
in subset: NCIthesaurus

antisocial personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.
imported from: doid.owl
has cross-reference: ICD10CM:F60.2
has cross-reference: ICD9CM:301.7
has cross-reference: MESH:D000987
has cross-reference: NCI:C88413
has cross-reference: SNOMEDCT_US_2020_03_01:191769004
has cross-reference: UMLS_CUI:C0003431
alternative_term: Asocial personality
alternative_term: Dissocial personality disorder
alternative_term: Psychopath.personality
alternative_term: Psychopathic personality
alternative_term: Psychopathic personality disorder
alternative_term: sociopathic personality
has_obo_namespace: disease_ontology
id: DOID:10939
in subset: NCIthesaurus

attention deficit hyperactivity disorder
type: Class
subclass of: specific developmental disorder
textual definition: A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age.
imported from: doid.owl
has_alternative_id: DOID:1093
has cross-reference: EFO:0003888
has cross-reference: MESH:D001289
has cross-reference: NCI:C35092
has cross-reference: OMIM:143465
has cross-reference: OMIM:608903
has cross-reference: OMIM:608904
has cross-reference: OMIM:608905
has cross-reference: OMIM:608906
has cross-reference: OMIM:612311
has cross-reference: OMIM:612312
has cross-reference: SNOMEDCT_US_2020_03_01:229713001
has cross-reference: UMLS_CUI:C0041671
alternative_term: ADHD
alternative_term: attention deficit disorder
alternative_term: hyperkinetic disorder
has_obo_namespace: disease_ontology
id: DOID:1094
in subset: NCIthesaurus
comment: Xref MGI.

intracranial aneurysm
type: Class
subclass of: cerebral arterial disease
imported from: doid.owl
has cross-reference: EFO:0003870
has cross-reference: MESH:D002532
has cross-reference: NCI:C34458
has cross-reference: SNOMEDCT_US_2020_03_01:128609009
has cross-reference: UMLS_CUI:C0007766
alternative_term: brain aneurysm
has_obo_namespace: disease_ontology
id: DOID:10941
in subset: NCIthesaurus

tongue disease
type: Class
subclass of: mouth disease
textual definition: A mouth disease located_in the tongue.
imported from: doid.owl
has cross-reference: ICD10CM:K14
has cross-reference: ICD9CM:529.9
has cross-reference: MESH:D014060
has cross-reference: SNOMEDCT_US_2020_03_01:69244009
has cross-reference: UMLS_CUI:C0040409
has_obo_namespace: disease_ontology
id: DOID:10944

nephritis
type: Class
subclass of: kidney disease
textual definition: A kidney disease that is characterized by an inflammation of the kidneys.
imported from: doid.owl
has cross-reference: ICD10CM:N08
has cross-reference: MESH:D009393
has cross-reference: NCI:C26833
has cross-reference: SNOMEDCT_US_2020_03_01:52845002
has cross-reference: UMLS_CUI:C0027697
has_obo_namespace: disease_ontology
id: DOID:10952
in subset: NCIthesaurus

strongyloidiasis
type: Class
subclass of: central nervous system disease
subclass of: skin disease
subclass of: intestinal disease
subclass of: lung disease
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.
imported from: doid.owl
has_alternative_id: DOID:0050008
has cross-reference: GARD:8195
has cross-reference: ICD10CM:B78
has cross-reference: ICD9CM:127.2
has cross-reference: MESH:D013322
has cross-reference: NCI:C128398
has cross-reference: SNOMEDCT_US_2020_03_01:1214006
has cross-reference: UMLS_CUI:C0038463
alternative_term: Infection by Strongyloides
alternative_term: disseminated strongyloidiasis
has_obo_namespace: disease_ontology
id: DOID:10955
in subset: NCIthesaurus

spastic diplegia
type: Class
subclass of: spastic cerebral palsy
textual definition: A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. The legs cross at the knees, making it difficult to walk.
imported from: doid.owl
has_alternative_id: DOID:3778
has cross-reference: ICD10CM:G80.1
has cross-reference: ICD9CM:343.0
has cross-reference: MESH:D002547
has cross-reference: NCI:C34781
has cross-reference: SNOMEDCT_US_2020_03_01:1178005
has cross-reference: SNOMEDCT_US_2020_03_01:275469001
has cross-reference: UMLS_CUI:C0023882
has cross-reference: UMLS_CUI:C0154695
alternative_term: Diplegic infantile cerebral palsy
alternative_term: Infantile spastic cerebral palsy
alternative_term: Little's disease
alternative_term: Littles disease
alternative_term: cerebral spastic infantile paralysis
alternative_term: infantile diplegic cerebral palsy
has_obo_namespace: disease_ontology
id: DOID:10965
in subset: NCIthesaurus

spastic hemiplegia
type: Class
subclass of: spastic cerebral palsy
textual definition: A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally.
imported from: doid.owl
has cross-reference: GARD:10448
has cross-reference: ICD9CM:343.1
has cross-reference: SNOMEDCT_US_2020_03_01:258714003
has cross-reference: UMLS_CUI:C0270805
alternative_term: Congenital hemiplegia
alternative_term: Hemiplegic cerebral palsy
alternative_term: Hemiplegic infantile cerebral palsy
alternative_term: hemiplegic cerebral palsy
alternative_term: spastic hemiplegic cerebral palsy
has_obo_namespace: disease_ontology
id: DOID:10967

hemiplegia
type: Class
subclass of: central nervous system disease
textual definition: A central nervous system disease that is characterized by the complete paralysis of half of the body.
imported from: doid.owl
has cross-reference: GARD:6583
has cross-reference: ICD9CM:343.4
has cross-reference: MESH:D006429
has cross-reference: SNOMEDCT_US_2020_03_01:155024003
has cross-reference: UMLS_CUI:C0392550
alternative_term: Infantile hemiplegia
alternative_term: Postnatal infantile hemiplegia
has_obo_namespace: disease_ontology
id: DOID:10969

spastic quadriplegia
type: Class
subclass of: spastic cerebral palsy
textual definition: A spastic cerebral palsy that affects all four limbs. The individuals have difficulty with walking and talking.
imported from: doid.owl
has cross-reference: ICD9CM:343.2
has cross-reference: MESH:D002547
has cross-reference: OMIM:603513
has cross-reference: OMIM:612900
has cross-reference: ORDO:210141
has cross-reference: SNOMEDCT_US_2020_03_01:192953000
has cross-reference: UMLS_CUI:C0154697
alternative_term: quadriplegic infantile cerebral palsy
alternative_term: spastic quadriplegic cerebral palsy
alternative_term: tetraplegic infantile cerebral palsy
has_obo_namespace: disease_ontology
id: DOID:10970
in subset: DO rare slim
comment: Xref MGI.

salpingo-oophoritis
type: Class
subclass of: oophoritis
imported from: doid.owl
has cross-reference: ICD10CM:N70
has cross-reference: ICD9CM:614.2
has cross-reference: SNOMEDCT_US_2020_03_01:46536000
has cross-reference: UMLS_CUI:C0036133
alternative_term: Salpingitis/oophoritis
alternative_term: Tubo-ovarian inflammatory disease
has_obo_namespace: disease_ontology
id: DOID:10972

acute salpingitis
type: Class
subclass of: salpingitis
imported from: doid.owl
has cross-reference: ICD10CM:N70.01
has cross-reference: NCI:C40120
has cross-reference: SNOMEDCT_US_2020_03_01:8912009
has cross-reference: UMLS_CUI:C0269038
has_obo_namespace: disease_ontology
id: DOID:10973
in subset: NCIthesaurus

oophoritis
type: Class
subclass of: ovarian disease
textual definition: An ovarian disease that is characterized by inflammation of the ovary.
imported from: doid.owl
has cross-reference: ICD10CM:N70.92
has cross-reference: MESH:D009869
has cross-reference: SNOMEDCT_US_2020_03_01:266648001
has cross-reference: UMLS_CUI:C0029051
has_obo_namespace: disease_ontology
id: DOID:10974

membranous glomerulonephritis
type: Class
subclass of: glomerulonephritis
imported from: doid.owl
has cross-reference: EFO:0004254
has cross-reference: ICD10CM:N03.2
has cross-reference: MESH:D015433
has cross-reference: NCI:C34645
has cross-reference: SNOMEDCT_US_2020_03_01:197710000
has cross-reference: UMLS_CUI:C0017665
alternative_term: membranous nephropathy
has_obo_namespace: disease_ontology
id: DOID:10976
in subset: NCIthesaurus

Alport syndrome
type: Class
subclass of: monogenic disease
subclass of: syndrome
textual definition: A syndrome disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss.
imported from: doid.owl
has cross-reference: GARD:5785
has cross-reference: MESH:D009394
has cross-reference: ORDO:63
has cross-reference: SNOMEDCT_US_2020_03_01:57333009
has cross-reference: UMLS_CUI:C0027706
alternative_term: Hereditary Nephritis
has_obo_namespace: disease_ontology
id: DOID:10983
in subset: DO MGI slim
comment: OMIM mapping confirmed by DO. [SN].

alpha thalassemia
type: Class
subclass of: thalassemia
textual definition: Alpha thalassemia is a thalassemia involving the genes HBA1and HBA2 hemoglobin genes.
imported from: doid.owl
has cross-reference: GARD:621
has cross-reference: ICD10CM:D56.0
has cross-reference: ICD9CM:282.43
has cross-reference: MESH:D017085
has cross-reference: NCI:C34368
has cross-reference: OMIM:604131
has cross-reference: SNOMEDCT_US_2020_03_01:191186002
has cross-reference: UMLS_CUI:C0002312
alternative_term: Alpha thalassaemia
alternative_term: alpha-Thalassemia
has_obo_namespace: disease_ontology
id: DOID:1099
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

acute hemorrhagic leukoencephalitis
type: Class
subclass of: acute disseminated encephalomyelitis
textual definition: A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema.
imported from: doid.owl
has cross-reference: GARD:8629
has cross-reference: MESH:D004684
has cross-reference: NCI:C84535
has cross-reference: OMIM:606752
has cross-reference: SNOMEDCT_US_2020_03_01:72986009
has cross-reference: UMLS_CUI:C0014077
alternative_term: AHL
alternative_term: Weston-Hurst syndrome
alternative_term: acute haemorrhagic leucoencephalitis of Weston Hurst
alternative_term: acute hemorrhagic encephalomyelitis
alternative_term: acute necrotizing hemorrhagic leukoencephalitis
has_obo_namespace: disease_ontology
id: DOID:10992
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

lens disease
type: Class
subclass of: eye disease
textual definition: An eye disease that affects the lens of the eye, which is the transparent disc that focuses light to the photosensors in the back of the eye.
imported from: doid.owl
has cross-reference: ICD10CM:H27.9
has cross-reference: MESH:D007905
has cross-reference: NCI:C26812
has cross-reference: SNOMEDCT_US_2020_03_01:194613002
has cross-reference: UMLS_CUI:C0023308
has_obo_namespace: disease_ontology
id: DOID:110
in subset: NCIthesaurus

ovarian disease
type: Class
subclass of: gonadal disease
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is located_in the ovary.
imported from: doid.owl
has cross-reference: MESH:D010049
has cross-reference: NCI:C26841
has cross-reference: SNOMEDCT_US_2020_03_01:5552004
has cross-reference: UMLS_CUI:C0029928
has_obo_namespace: disease_ontology
id: DOID:1100
in subset: NCIthesaurus

pseudopterygium
type: Class
subclass of: corneal disease
imported from: doid.owl
has cross-reference: ICD9CM:372.52
has cross-reference: SNOMEDCT_US_2020_03_01:66139007
has cross-reference: UMLS_CUI:C0155161
has_obo_namespace: disease_ontology
id: DOID:11028

pinguecula
type: Class
subclass of: conjunctival degeneration
imported from: doid.owl
has cross-reference: ICD10CM:H11.15
has cross-reference: ICD9CM:372.51
has cross-reference: MESH:D059407
has cross-reference: NCI:C129468
has cross-reference: SNOMEDCT_US_2020_03_01:267735001
has cross-reference: UMLS_CUI:C0152255
has_obo_namespace: disease_ontology
id: DOID:11029
in subset: NCIthesaurus

corneal edema
type: Class
subclass of: corneal disease
imported from: doid.owl
has cross-reference: ICD10CM:H18.20
has cross-reference: ICD9CM:371.2
has cross-reference: MESH:D015715
has cross-reference: NCI:C50508
has cross-reference: SNOMEDCT_US_2020_03_01:193811006
has cross-reference: UMLS_CUI:C0010037
alternative_term: Corneal oedema
has_obo_namespace: disease_ontology
id: DOID:11030
in subset: NCIthesaurus

bullous keratopathy
type: Class
subclass of: corneal edema
imported from: doid.owl
has cross-reference: ICD10CM:H18.1
has cross-reference: ICD9CM:371.23
has cross-reference: NCI:C26970
has cross-reference: SNOMEDCT_US_2020_03_01:193815002
has cross-reference: UMLS_CUI:C0155111
has_obo_namespace: disease_ontology
id: DOID:11031
in subset: NCIthesaurus

idiopathic corneal edema
type: Class
subclass of: corneal edema
imported from: doid.owl
has cross-reference: ICD10CM:H18.22
has cross-reference: ICD9CM:371.21
has cross-reference: SNOMEDCT_US_2020_03_01:193813009
has cross-reference: UMLS_CUI:C0155109
has_obo_namespace: disease_ontology
id: DOID:11033

dissociative amnesia
type: Class
subclass of: dissociative disorder
textual definition: A dissociative disorder where he continuity of the patient's memory is disrupted. Patients with dissociative amnesia have recurrent episodes in which they forget important personal information or events, usually connected with trauma or severe stress.
imported from: doid.owl
has cross-reference: ICD10CM:F44.0
has cross-reference: ICD9CM:300.12
has cross-reference: MESH:D000647
has cross-reference: NCI:C94328
has cross-reference: SNOMEDCT_US_2020_03_01:192420000
has cross-reference: UMLS_CUI:C0236795
alternative_term: psychogenic amnesia
has_obo_namespace: disease_ontology
id: DOID:11037
in subset: NCIthesaurus

depersonalization disorder
type: Class
subclass of: dissociative disorder
textual definition: A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization.
imported from: doid.owl
has cross-reference: GARD:6260
has cross-reference: ICD9CM:300.6
has cross-reference: MESH:D003861
has cross-reference: NCI:C94331
has cross-reference: SNOMEDCT_US_2020_03_01:70764005
has cross-reference: UMLS_CUI:C0683416
alternative_term: Neurotic derealization
has_obo_namespace: disease_ontology
id: DOID:11038
in subset: NCIthesaurus

Felty's syndrome
type: Class
subclass of: syndrome
subclass of: autoimmune disease
textual definition: A syndrome that results_in rheumatoid arthritis, splenomegaly and neutropenia.
imported from: doid.owl
has cross-reference: GARD:8234
has cross-reference: ICD10CM:M05.0
has cross-reference: ICD9CM:714.1
has cross-reference: MESH:D005258
has cross-reference: NCI:C84712
has cross-reference: OMIM:134750
has cross-reference: SNOMEDCT_US_2020_03_01:57160007
has cross-reference: UMLS_CUI:C0015773
alternative_term: Felty syndrome
alternative_term: Rheumatoid arthritis with splenoadenomegaly and leukopenia
has_obo_namespace: disease_ontology
id: DOID:11042
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

gastroschisis
type: Class
subclass of: physical disorder
imported from: doid.owl
has cross-reference: GARD:8661
has cross-reference: ICD10CM:Q79.3
has cross-reference: ICD9CM:756.73
has cross-reference: MESH:D020139
has cross-reference: NCI:C84725
has cross-reference: OMIM:230750
has cross-reference: SNOMEDCT_US_2020_03_01:72951007
has cross-reference: UMLS_CUI:C0265706
has_obo_namespace: disease_ontology
id: DOID:11044
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

meconium aspiration syndrome
type: Class
subclass of: lung disease
textual definition: A lung disease that is characterized by a newborn breathing in a mixture of meconium and amniotic fluid into the lungs around the time of delivery.
imported from: doid.owl
has cross-reference: GARD:10494
has cross-reference: ICD10CM:P24.01
has cross-reference: MESH:D008471
has cross-reference: NCI:C87093
has cross-reference: SNOMEDCT_US_2020_03_01:85779008
has cross-reference: UMLS_CUI:C0025048
alternative_term: Neonatal aspiration of meconium
alternative_term: meconium aspiration
has_obo_namespace: disease_ontology
id: DOID:11049
in subset: NCIthesaurus

urinary bladder cancer
type: Class
subclass of: bladder disease
subclass of: urinary system cancer
textual definition: An urinary system cancer that results_in malignant growth located_in the urinary bladder.
imported from: doid.owl
has_alternative_id: DOID:5428
has cross-reference: GARD:12210
has cross-reference: ICD10CM:C67
has cross-reference: ICD9CM:188
has cross-reference: KEGG:05219
has cross-reference: MESH:D001749
has cross-reference: NCI:C2901
has cross-reference: NCI:C9334
has cross-reference: OMIM:109800
has cross-reference: SNOMEDCT_US_2020_03_01:126885006
has cross-reference: SNOMEDCT_US_2020_03_01:363455001
has cross-reference: UMLS_CUI:C0005684
has cross-reference: UMLS_CUI:C0005695
alternative_term: bladder cancer
alternative_term: tumor of the bladder
has_obo_namespace: disease_ontology
id: DOID:11054
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: OMIM mapping confirmed by DO. [SN].

pasteurellosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.
imported from: doid.owl
has cross-reference: ICD10CM:A28.0
has cross-reference: ICD9CM:027.2
has cross-reference: MESH:D010326
has cross-reference: SNOMEDCT_US_2020_03_01:276199008
has cross-reference: UMLS_CUI:C0030636
alternative_term: Pasteurella infection
alternative_term: Pasteurella infectious disease
has_obo_namespace: disease_ontology
id: DOID:11055
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

placenta praevia
type: Class
subclass of: placenta disease
textual definition: A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.
imported from: doid.owl
has cross-reference: ICD10CM:O44
has cross-reference: MESH:D010923
has cross-reference: NCI:C26858
has cross-reference: SNOMEDCT_US_2020_03_01:157059004
has cross-reference: UMLS_CUI:C0032046
has_obo_namespace: disease_ontology
id: DOID:11060
in subset: NCIthesaurus

esophageal carcinoma
type: Class
subclass of: carcinoma
subclass of: esophageal cancer
textual definition: A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: EFO:0002916
has cross-reference: NCI:C3513
has cross-reference: SNOMEDCT_US_2020_03_01:255079005
has cross-reference: UMLS_CUI:C0152018
alternative_term: cancer of esophagus
alternative_term: cancer of oesophagus
alternative_term: carcinoma OF ESOPHAGUS
alternative_term: carcinoma of esophagus
alternative_term: carcinoma of oesophagus
has_obo_namespace: disease_ontology
id: DOID:1107
in subset: DO cancer slim
in subset: NCIthesaurus

brucellosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.
imported from: doid.owl
has_alternative_id: DOID:0050060
has cross-reference: GARD:5966
has cross-reference: ICD10CM:A23
has cross-reference: ICD9CM:023
has cross-reference: MESH:D002006
has cross-reference: NCI:C84602
has cross-reference: SNOMEDCT_US_2020_03_01:154296006
has cross-reference: UMLS_CUI:C0006309
alternative_term: Maltese fever
alternative_term: undulant fever
has_obo_namespace: disease_ontology
has_related_synonym: Bang's disease
has_related_synonym: Gibraltar fever
has_related_synonym: Malta fever
has_related_synonym: Mediterranean fever
id: DOID:11077
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

myiasis
type: Class
subclass of: parasitic ectoparasitic infectious disease
textual definition: A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue.
imported from: doid.owl
has cross-reference: ICD10CM:B87
has cross-reference: ICD9CM:134.0
has cross-reference: MESH:D009198
has cross-reference: NCI:C128400
has cross-reference: SNOMEDCT_US_2020_03_01:266225001
has cross-reference: UMLS_CUI:C0027030
alternative_term: Infestation by fly larvae
alternative_term: Infestation by maggots
alternative_term: Maggot infestation
has_obo_namespace: disease_ontology
id: DOID:11080
in subset: NCIthesaurus

chorioretinal scar
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: ICD10CM:H31.0
has cross-reference: ICD9CM:363.3
has cross-reference: SNOMEDCT_US_2020_03_01:53854005
has cross-reference: UMLS_CUI:C0008512
has_obo_namespace: disease_ontology
id: DOID:11086

asphyxia neonatorum
type: Class
subclass of: respiratory system disease
textual definition: A respiratory system disease that is characterized by deprivation of oxygen to a newborn infant that lasts long enough during the birth process to cause physical harm, usually to the brain.
imported from: doid.owl
has cross-reference: GARD:5857
has cross-reference: ICD10CM:P84
has cross-reference: ICD9CM:768.9
has cross-reference: MESH:D001238
has cross-reference: SNOMEDCT_US_2020_03_01:413654009
has cross-reference: UMLS_CUI:C0004045
alternative_term: Asphyxia - birth
alternative_term: Asphyxia, in liveborn infant
alternative_term: Birth asphyxia
alternative_term: postnatal asphyxia
has_obo_namespace: disease_ontology
id: DOID:11088

Q fever
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.
imported from: doid.owl
has cross-reference: GARD:7515
has cross-reference: ICD10CM:A78
has cross-reference: ICD9CM:083.0
has cross-reference: MESH:D011778
has cross-reference: NCI:C34970
has cross-reference: SNOMEDCT_US_2020_03_01:266205000
has cross-reference: UMLS_CUI:C0034362
alternative_term: Infection due to Coxiella burnetii
has_obo_namespace: disease_ontology
id: DOID:11100
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

trench fever
type: Class
subclass of: bartonellosis
textual definition: A primary bacterial infectious disease that results in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.
imported from: doid.owl
has cross-reference: ICD10CM:A79.0
has cross-reference: ICD9CM:083.1
has cross-reference: MESH:D014205
has cross-reference: SNOMEDCT_US_2020_03_01:82214002
has cross-reference: UMLS_CUI:C0040830
alternative_term: His-Werner disease
alternative_term: Quintan fever
alternative_term: Wolhynian fever
alternative_term: shin bone fever
alternative_term: tibialgic fever
has_obo_namespace: disease_ontology
id: DOID:11101
in subset: gram-negative bacterial infectious disease

bartonellosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella.
imported from: doid.owl
has cross-reference: ICD10CM:A44
has cross-reference: ICD9CM:088.0
has cross-reference: MESH:D001474
has cross-reference: NCI:C84586
has cross-reference: SNOMEDCT_US_2020_03_01:17116008
has cross-reference: UMLS_CUI:C0004771
alternative_term: Bartonella infectious disease
alternative_term: Rochalimaea infection
alternative_term: bartonelliasis
has_obo_namespace: disease_ontology
id: DOID:11102
in subset: GOLD
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease

spotted fever
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.
imported from: doid.owl
has cross-reference: GARD:4998
has cross-reference: ICD10CM:A77.9
has cross-reference: ICD9CM:082.0
has cross-reference: MESH:D000073605
has cross-reference: SNOMEDCT_US_2020_03_01:186771002
has cross-reference: UMLS_CUI:C0038041
alternative_term: Spotted fever group rickettsial disease
has_obo_namespace: disease_ontology
id: DOID:11104
in subset: gram-negative bacterial infectious disease

fundus albipunctatus
type: Class
subclass of: fundus dystrophy
textual definition: A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement.
imported from: doid.owl
has cross-reference: MESH:C562733
has cross-reference: OMIM:136880
has cross-reference: SNOMEDCT_US_2020_03_01:68222009
has cross-reference: UMLS_CUI:C0311338
alternative_term: Pigmentary retinal dystrophy
alternative_term: retinitis punctata albescens
has_obo_namespace: disease_ontology
id: DOID:11105
comment: OMIM mapping confirmed by DO. [SN].

hydronephrosis
type: Class
subclass of: urinary tract obstruction
imported from: doid.owl
has cross-reference: ICD10CM:N13.30
has cross-reference: ICD9CM:591
has cross-reference: MESH:D006869
has cross-reference: NCI:C26796
has cross-reference: SNOMEDCT_US_2020_03_01:155866001
has cross-reference: UMLS_CUI:C0020295
has_obo_namespace: disease_ontology
id: DOID:11111
in subset: NCIthesaurus

Gilles de la Tourette syndrome
type: Class
subclass of: tic disorder
textual definition: A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.
imported from: doid.owl
has cross-reference: EFO:0004895
has cross-reference: GARD:7783
has cross-reference: ICD10CM:F95.2
has cross-reference: ICD9CM:307.23
has cross-reference: MESH:D005879
has cross-reference: NCI:C35078
has cross-reference: OMIM:137580
has cross-reference: SNOMEDCT_US_2020_03_01:5158005
has cross-reference: UMLS_CUI:C0040517
alternative_term: Guinon's disease
alternative_term: Psychogenic tics
alternative_term: Tourette syndrome
alternative_term: motor-verbal tic disorder
has_obo_namespace: disease_ontology
id: DOID:11119
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pulpitis
type: Class
subclass of: dental pulp disease
imported from: doid.owl
has cross-reference: ICD10CM:K04.0
has cross-reference: ICD9CM:522.0
has cross-reference: MESH:D011671
has cross-reference: NCI:C52595
has cross-reference: SNOMEDCT_US_2020_03_01:155638006
has cross-reference: UMLS_CUI:C0034103
has_obo_namespace: disease_ontology
id: DOID:11121
in subset: NCIthesaurus

Henoch-Schoenlein purpura
type: Class
subclass of: DOID 9809
textual definition: A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection.
imported from: doid.owl
has cross-reference: GARD:8204
has cross-reference: ICD10CM:D69.0
has cross-reference: ICD9CM:287.0
has cross-reference: MESH:D011695
has cross-reference: NCI:C34963
has cross-reference: SNOMEDCT_US_2020_03_01:191306005
has cross-reference: UMLS_CUI:C0034152
alternative_term: Allergic purpura
alternative_term: Autoimmune purpura
alternative_term: Henoch-Sch?nlein purpura
alternative_term: Henoch-Sch@nlein purpura
alternative_term: Henoch-Scholein purpura
alternative_term: Henoch-Schonlein Purpura
alternative_term: Purpura, autoimmune
has_obo_namespace: disease_ontology
id: DOID:11123
in subset: NCIthesaurus

prostatic hypertrophy
type: Class
subclass of: prostate disease
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:11132

sarcoma
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm.
imported from: doid.owl
has_alternative_id: DOID:3936
has cross-reference: ICD10CM:C49
has cross-reference: ICD9CM:171.9
has cross-reference: SNOMEDCT_US_2020_03_01:93765001
has cross-reference: UMLS_CUI:C0153519
alternative_term: connective and soft tissue neoplasm
alternative_term: tumor of soft tissue and skeleton
has_obo_namespace: disease_ontology
id: DOID:1115
in subset: DO cancer slim
in subset: TopNodes DOcancerslim

cholecystolithiasis
type: Class
subclass of: gallbladder disease
imported from: doid.owl
has cross-reference: MESH:D041761
has cross-reference: NCI:C34443
has cross-reference: SNOMEDCT_US_2020_03_01:235919008
has cross-reference: UMLS_CUI:C0947622
has_obo_namespace: disease_ontology
id: DOID:11151
in subset: NCIthesaurus

miliaria rubra
type: Class
subclass of: miliaria
textual definition: A miliaria that is characterized by erythematous papules resulting in leakage of sweat into the deeper, subcorneal layers of the epidermis provoking a local inflammatory reaction.
imported from: doid.owl
has cross-reference: ICD10CM:L74.0
has cross-reference: ICD9CM:705.1
has cross-reference: MESH:D008883
has cross-reference: SNOMEDCT_US_2020_03_01:44279002
has cross-reference: UMLS_CUI:C0162423
alternative_term: prickly heat
has_obo_namespace: disease_ontology
id: DOID:11153

hypohidrosis
type: Class
subclass of: sweat gland disease
textual definition: A sweat gland disease that is characterized by reduced ability to sweat, has_symptom hyperthermia and dry skin of affected areas, and has_material_basis_in trauma to the sweat glands.
imported from: doid.owl
has cross-reference: ICD10CM:L74.4
has cross-reference: MESH:D007007
has cross-reference: NCI:C34718
has cross-reference: SNOMEDCT_US_2020_03_01:201189007
has cross-reference: UMLS_CUI:C0020620
alternative_term: Hypohidrosis
alternative_term: Oligohidrosis
has_obo_namespace: disease_ontology
id: DOID:11155
in subset: NCIthesaurus

anhidrosis
type: Class
subclass of: hypohidrosis
textual definition: A hypohidrosis that is characterized by the inability to sweat and has_symptom hyperthermia and dry skin.
imported from: doid.owl
has cross-reference: ICD10CM:L74.4
has cross-reference: ICD9CM:705.0
has cross-reference: MESH:D007007
has cross-reference: NCI:C34385
has cross-reference: OMIM:206600
has cross-reference: SNOMEDCT_US_2020_03_01:201189007
has cross-reference: UMLS_CUI:C0003028
alternative_term: Adiaphoresis
alternative_term: absence of sweating
has_obo_namespace: disease_ontology
id: DOID:11156
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pertussis
type: Class
subclass of: commensal bacterial infectious disease
textual definition: A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).
imported from: doid.owl
has_alternative_id: DOID:11333
has_alternative_id: DOID:11751
has cross-reference: KEGG:05133
has cross-reference: MESH:D001885
has cross-reference: SNOMEDCT_US_2020_03_01:26484003
has cross-reference: UMLS_CUI:C0006015
alternative_term: WC - Whooping cough
alternative_term: bordetella infection
alternative_term: whooping cough
has_obo_namespace: disease_ontology
id: DOID:1116
in subset: gram-negative bacterial infectious disease

respiratory failure
type: Class
subclass of: lung disease
textual definition: A lung disease characterized by inadequate gas exchange by the respiratory system.
imported from: doid.owl
has_alternative_id: DOID:11391
has_alternative_id: DOID:11392
has_alternative_id: DOID:11393
has cross-reference: ICD10CM:J96.0
has cross-reference: ICD9CM:518.81
has cross-reference: NCI:C27043
has cross-reference: SNOMEDCT_US_2020_03_01:65710008
has cross-reference: UMLS_CUI:C0264490
alternative_term: acute and chronic respiratory failure
alternative_term: acute respiratory Failure
alternative_term: acute-on-chronic respiratory failure
alternative_term: chronic respiratory failure
alternative_term: respiratory insufficiency/failure
has_obo_namespace: disease_ontology
id: DOID:11162
in subset: NCIthesaurus

band keratopathy
type: Class
subclass of: corneal degeneration
imported from: doid.owl
has cross-reference: ICD10CM:H18.42
has cross-reference: ICD9CM:371.43
has cross-reference: MESH:C562399
has cross-reference: NCI:C118765
has cross-reference: OMIM:217500
has cross-reference: SNOMEDCT_US_2020_03_01:35055000
has cross-reference: UMLS_CUI:C0155120
alternative_term: Band-shaped keratopathy
has_obo_namespace: disease_ontology
id: DOID:11164
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

common wart
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.
imported from: doid.owl
has cross-reference: ICD10CM:B07.8
has cross-reference: ICD9CM:078.1
has cross-reference: NCI:C27087
has cross-reference: SNOMEDCT_US_2020_03_01:57019003
has cross-reference: UMLS_CUI:C0043037
has_obo_namespace: disease_ontology
id: DOID:11165
in subset: NCIthesaurus

anogenital venereal wart
type: Class
subclass of: herpangina
subclass of: vaginal disease
subclass of: penile disease
subclass of: cervix disease
subclass of: anus disease
textual definition: A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.
imported from: doid.owl
has_alternative_id: DOID:7877
has cross-reference: ICD10CM:A63.0
has cross-reference: ICD9CM:078.11
has cross-reference: MESH:D003218
has cross-reference: NCI:C2960
has cross-reference: NCI:C4820
has cross-reference: SNOMEDCT_US_2020_03_01:240542006
has cross-reference: SNOMEDCT_US_2020_03_01:302812006
has cross-reference: UMLS_CUI:C0009663
has cross-reference: UMLS_CUI:C0554632
alternative_term: Anogenital Human papilloma Virus Infectious Disease
alternative_term: Anogenital warts
alternative_term: Genital warts
alternative_term: genital wart virus infectious disease
alternative_term: venereal wart
has_obo_namespace: disease_ontology
has_related_synonym: Condyloma acuminatum
id: DOID:11168
in subset: NCIthesaurus
in subset: sexually transmitted infectious disease

enophthalmos
type: Class
subclass of: DOID 930
imported from: doid.owl
has cross-reference: ICD10CM:H05.4
has cross-reference: ICD9CM:376.5
has cross-reference: MESH:D015841
has cross-reference: NCI:C79552
has cross-reference: SNOMEDCT_US_2020_03_01:267746003
has cross-reference: UMLS_CUI:C0014306
has_obo_namespace: disease_ontology
id: DOID:11175
in subset: NCIthesaurus

non-suppurative otitis media
type: Class
subclass of: otitis media
textual definition: A otitis media which involves transudation of fluid in the middle ear without pus formation.
imported from: doid.owl
has cross-reference: ICD10CM:H65
has cross-reference: ICD9CM:381.4
has cross-reference: SNOMEDCT_US_2020_03_01:275481002
has cross-reference: UMLS_CUI:C0271446
alternative_term: Nonsuppurative otitis media
has_obo_namespace: disease_ontology
id: DOID:11180

acute conjunctivitis
type: Class
subclass of: conjunctivitis
imported from: doid.owl
has cross-reference: ICD10CM:H10.02
has cross-reference: ICD9CM:372.03
has cross-reference: UMLS_CUI:C0029668
has_obo_namespace: disease_ontology
id: DOID:11184

syndactyly
type: Class
subclass of: chromosomal duplication syndrome
subclass of: synostosis
textual definition: A synostosis that results_in the fusion of two or more digits.
imported from: doid.owl
has cross-reference: GARD:13181
has cross-reference: ICD10CM:Q70
has cross-reference: ICD9CM:755.1
has cross-reference: MESH:D013576
has cross-reference: NCI:C87125
has cross-reference: ORDO:295012
has cross-reference: ORDO:90025
has cross-reference: ORDO:93403
has cross-reference: SNOMEDCT_US_2020_03_01:156989004
has cross-reference: UMLS_CUI:C0039075
alternative_term: chromosome 2q35 duplication syndrome
alternative_term: symphalangism
alternative_term: symphalangy
alternative_term: webbing of digits
has_obo_namespace: disease_ontology
id: DOID:11193
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

DiGeorge syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: chromosomal deletion syndrome
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in a large deletion of the chromosome 22q11.2 region which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production.
imported from: doid.owl
has cross-reference: GARD:10299
has cross-reference: ICD10CM:D82.1
has cross-reference: ICD9CM:279.11
has cross-reference: MESH:D004062
has cross-reference: NCI:C2989
has cross-reference: OMIM:188400
has cross-reference: SNOMEDCT_US_2020_03_01:77128003
has cross-reference: UMLS_CUI:C0012236
alternative_term: 22q11.2 deletion syndrome
alternative_term: DiGeorge sequence
alternative_term: DiGeorge's syndrome
alternative_term: Pharyngeal pouch syndrome
has_obo_namespace: disease_ontology
id: DOID:11198
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hypoparathyroidism
type: Class
subclass of: parathyroid gland disease
textual definition: A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.
imported from: doid.owl
has cross-reference: GARD:6733
has cross-reference: ICD10CM:E20
has cross-reference: ICD9CM:252.1
has cross-reference: MESH:D007011
has cross-reference: NCI:C78350
has cross-reference: OMIM:146200
has cross-reference: OMIM:307700
has cross-reference: ORDO:2238
has cross-reference: SNOMEDCT_US_2020_03_01:154697005
has cross-reference: UMLS_CUI:C0020626
has_obo_namespace: disease_ontology
id: DOID:11199
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

esophageal varix
type: Class
subclass of: esophageal disease
subclass of: DOID 866
imported from: doid.owl
has_alternative_id: DOID:111
has_alternative_id: DOID:13536
has_alternative_id: DOID:14031
has cross-reference: GARD:6384
has cross-reference: ICD10CM:I85.01
has cross-reference: ICD9CM:456.0
has cross-reference: ICD9CM:456.2
has cross-reference: ICD9CM:456.20
has cross-reference: NCI:C78282
has cross-reference: SNOMEDCT_US_2020_03_01:195475003
has cross-reference: SNOMEDCT_US_2020_03_01:195643006
has cross-reference: SNOMEDCT_US_2020_03_01:236067006
has cross-reference: UMLS_CUI:C0155789
has cross-reference: UMLS_CUI:C0155791
has cross-reference: UMLS_CUI:C0155792
alternative_term: Bleeding esophageal varices
alternative_term: Bleeding oesophageal varices
alternative_term: esophageal varices
alternative_term: esophageal varices in disease classified elsewhere, with bleeding
alternative_term: esophageal varices with bleeding
alternative_term: esophageal varices with bleeding in disease EC
alternative_term: esophageal varices without bleeding
alternative_term: esophageal varices without mention of bleeding
has_obo_namespace: disease_ontology
id: DOID:112
in subset: NCIthesaurus

T cell deficiency
type: Class
subclass of: primary immunodeficiency disease
textual definition: A primary immunodeficiency disease that is characterized by decreased numbers of circulating or functioning T cells.
imported from: doid.owl
has_alternative_id: DOID:613
has cross-reference: NCI:C27145
has cross-reference: NCI:C27872
has cross-reference: SNOMEDCT_US_2020_03_01:402792003
has cross-reference: UMLS_CUI:C1274233
has cross-reference: UMLS_CUI:C1333147
alternative_term: T cell immunodeficiency
alternative_term: T lymphocyte deficiency
alternative_term: T lymphocyte immunodeficiency
has_obo_namespace: disease_ontology
id: DOID:11200
in subset: NCIthesaurus

parathyroid gland disease
type: Class
subclass of: endocrine system disease
textual definition: An endocrine system disease that is located_in the parathyroid gland.
imported from: doid.owl
has cross-reference: ICD10CM:E21.5
has cross-reference: ICD9CM:252.9
has cross-reference: MESH:D010279
has cross-reference: NCI:C26844
has cross-reference: SNOMEDCT_US_2020_03_01:73132005
has cross-reference: UMLS_CUI:C0030517
alternative_term: disease of parathyroid glands
has_obo_namespace: disease_ontology
id: DOID:11201
in subset: NCIthesaurus

allergic conjunctivitis
type: Class
subclass of: allergic disease
subclass of: chronic conjunctivitis
textual definition: A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant.
imported from: doid.owl
has cross-reference: MESH:D003233
has cross-reference: NCI:C34506
has cross-reference: SNOMEDCT_US_2020_03_01:231854006
has cross-reference: UMLS_CUI:C0009766
has_obo_namespace: disease_ontology
id: DOID:11204
in subset: NCIthesaurus

opioid abuse
type: Class
subclass of: substance abuse
textual definition: A substance abuse that involves the recurring use of opioid drugs despite negative consequences.
imported from: doid.owl
has cross-reference: ICD10CM:F11.1
has cross-reference: ICD9CM:305.5
has cross-reference: MESH:D009293
has cross-reference: SNOMEDCT_US_2020_03_01:5602001
has cross-reference: UMLS_CUI:C0029095
has_obo_namespace: disease_ontology
id: DOID:11206

acute hemorrhagic conjunctivitis
type: Class
subclass of: conjunctival disease
subclass of: DOID 934
textual definition: A viral infectious disease that results in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.
imported from: doid.owl
has cross-reference: ICD9CM:077.4
has cross-reference: MESH:D003232
has cross-reference: NCI:C34505
has cross-reference: SNOMEDCT_US_2020_03_01:186677009
has cross-reference: UMLS_CUI:C0009765
alternative_term: Apollo disease
alternative_term: Epidemic hemorrhagic conjunctivitis
has_obo_namespace: disease_ontology
has_related_synonym: viral conjunctivitis
id: DOID:11227
in subset: NCIthesaurus

acute orbital inflammation
type: Class
subclass of: DOID 930
imported from: doid.owl
has cross-reference: ICD10CM:H05.0
has cross-reference: ICD9CM:376.0
has cross-reference: SNOMEDCT_US_2020_03_01:20551005
has cross-reference: UMLS_CUI:C0155256
alternative_term: acute inflammation of orbit
has_obo_namespace: disease_ontology
id: DOID:11230

orbital cellulitis
type: Class
subclass of: acute orbital inflammation
textual definition: An acute orbital inflammation that is characterized by painful orbital mass and has_symptom eyelid edema, has_symptom erythema, has_symptom chemiosis, has_symptom proptosis, has_symptom blurred vision, has_symptom headache, has_symptom fever and has_symptom double vision.
imported from: doid.owl
has cross-reference: ICD10CM:H05.01
has cross-reference: ICD9CM:376.01
has cross-reference: MESH:D054517
has cross-reference: NCI:C99000
has cross-reference: SNOMEDCT_US_2020_03_01:194005002
has cross-reference: UMLS_CUI:C0149507
has_obo_namespace: disease_ontology
id: DOID:11234
in subset: NCIthesaurus

appendix cancer
type: Class
subclass of: intestinal cancer
subclass of: appendix disease
textual definition: A intestinal cancer that is located_in the appendix.
imported from: doid.owl
has cross-reference: ICD10CM:C18.1
has cross-reference: ICD9CM:153.5
has cross-reference: MESH:D001063
has cross-reference: NCI:C9333
has cross-reference: SNOMEDCT_US_2020_03_01:93679002
has cross-reference: UMLS_CUI:C0496779
alternative_term: cancer of the appendix
alternative_term: malignant neoplasm of appendix vermiformis
alternative_term: malignant tumor of appendix
alternative_term: malignant tumor of the appendix
has_obo_namespace: disease_ontology
id: DOID:11239
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

appendiceal neoplasm
type: Class
subclass of: intestinal benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D001063
has cross-reference: NCI:C4434
has cross-reference: SNOMEDCT_US_2020_03_01:126846004
has cross-reference: UMLS_CUI:C0003614
alternative_term: appendix neoplasm
alternative_term: neoplasm of appendix
has_obo_namespace: disease_ontology
id: DOID:11240
in subset: NCIthesaurus

neonatal anemia
type: Class
subclass of: anemia
imported from: doid.owl
has cross-reference: MESH:D000751
has cross-reference: SNOMEDCT_US_2020_03_01:111468003
has cross-reference: UMLS_CUI:C0002891
alternative_term: anaemia neonatal
alternative_term: anemia neonatal
alternative_term: neonatal anaemia
has_obo_namespace: disease_ontology
id: DOID:11244

disseminated intravascular coagulation
type: Class
subclass of: thrombophilia
imported from: doid.owl
has cross-reference: ICD10CM:D65
has cross-reference: ICD9CM:286.6
has cross-reference: MESH:D004211
has cross-reference: NCI:C2992
has cross-reference: SNOMEDCT_US_2020_03_01:67406007
has cross-reference: UMLS_CUI:C0012739
alternative_term: DIC
alternative_term: Defibrination syndrome
alternative_term: Diffuse or disseminated intravascular coagulation
has_obo_namespace: disease_ontology
id: DOID:11247
in subset: NCIthesaurus

vitamin K deficiency bleeding
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by easy bleeding due to an inability to form blood clots caused by vitamin K deficiency, occurs most commonly in newborns, and has_material_basis_in deficiency of vitamin K secondary to liver prematurity, lack of vitamin K in a breastmillk diet, largely sterile gut, malabsorption, diarrhea, chronic illness, menorrhagia, chronic kidney disease, and some medications.
imported from: doid.owl
has cross-reference: ICD10CM:E56.1
has cross-reference: ICD9CM:269.0
has cross-reference: MESH:D014813
has cross-reference: NCI:C99108
has cross-reference: SNOMEDCT_US_2020_03_01:52675005
has cross-reference: UMLS_CUI:C0042880
alternative_term: deficiency of vitamin K
alternative_term: vitamin K deficiency
alternative_term: vitamin K deficiency hemorrhagic disease
has_obo_namespace: disease_ontology
id: DOID:11249
in subset: NCIthesaurus

typhus
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that refers to a group of diseases, located in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted by lice, transmitted by fleas, and transmitted by mites.
imported from: doid.owl
has_alternative_id: DOID:11255
has_alternative_id: DOID:12353
has cross-reference: GARD:7833
has cross-reference: ICD10CM:A75.0
has cross-reference: ICD10CM:A75.2
has cross-reference: ICD10CM:A75.9
has cross-reference: ICD9CM:080
has cross-reference: ICD9CM:081.0
has cross-reference: ICD9CM:081.9
has cross-reference: MESH:D014437
has cross-reference: MESH:D014438
has cross-reference: NCI:C84688
has cross-reference: NCI:C84689
has cross-reference: SNOMEDCT_US_2020_03_01:154375001
has cross-reference: SNOMEDCT_US_2020_03_01:25668000
has cross-reference: SNOMEDCT_US_2020_03_01:39111003
has cross-reference: UMLS_CUI:C0041471
has cross-reference: UMLS_CUI:C0041472
has cross-reference: UMLS_CUI:C0041473
alternative_term: Endemic Typhus fever
alternative_term: Exanthematic Typhus fever
alternative_term: Flea typhus
alternative_term: Louse-borne [epidemic] typhus
alternative_term: Moscow typhus
alternative_term: Murine [endemic] typhus
alternative_term: Typhus fever
alternative_term: endemic flea-borne typhus
alternative_term: epidemic louse-borne typhus
has_obo_namespace: disease_ontology
has_related_synonym: Classical typhus
has_related_synonym: Epidemic (louse-borne) typhus
has_related_synonym: Epidemic louse-borne typhus fever due to Rickettsia prowazekii
has_related_synonym: European typhus
has_related_synonym: Exanthematous typhus
has_related_synonym: Famine fever
has_related_synonym: Flea-borne rickettsiosis
has_related_synonym: Flea-borne typhus
has_related_synonym: Hospital fever
has_related_synonym: Jail fever
has_related_synonym: Louse-borne rickettsiosis
has_related_synonym: Louse-borne typhus
has_related_synonym: Mexican typhus
has_related_synonym: Murine typhus
has_related_synonym: Petechial fever
has_related_synonym: Prison fever
has_related_synonym: Rat flea typhus
has_related_synonym: Ship fever
has_related_synonym: Shop typhus
has_related_synonym: Typhus exanthematique
has_related_synonym: Urban typhus
id: DOID:11256
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

cat-scratch disease
type: Class
subclass of: bartonellosis
subclass of: DOID 9942
textual definition: A bartonellosis that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain.
imported from: doid.owl
has cross-reference: ICD10CM:A28.1
has cross-reference: ICD9CM:078.3
has cross-reference: MESH:D002372
has cross-reference: NCI:C84620
has cross-reference: SNOMEDCT_US_2020_03_01:123319006
has cross-reference: UMLS_CUI:C0007361
alternative_term: Debre's Syndrome
alternative_term: Debre-Mollaret Syndrome
alternative_term: Foshay-Mollaret Cat Scratch Fever
alternative_term: benign lymphoreticulosis
alternative_term: cat scratch fever
has_obo_namespace: disease_ontology
id: DOID:11258
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

rabies
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results in inflammation located in brain or located in spinal cord, has_material_basis_in Rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. The infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis.
imported from: doid.owl
has cross-reference: GARD:7516
has cross-reference: ICD10CM:A82
has cross-reference: ICD9CM:071
has cross-reference: MESH:D011818
has cross-reference: NCI:C28182
has cross-reference: SNOMEDCT_US_2020_03_01:14168008
has cross-reference: UMLS_CUI:C0034494
alternative_term: Lyssa
has_obo_namespace: disease_ontology
id: DOID:11260
in subset: NCIthesaurus
in subset: zoonotic infectious disease

ornithosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.
imported from: doid.owl
has cross-reference: ICD10CM:A70
has cross-reference: ICD9CM:073
has cross-reference: MESH:D009956
has cross-reference: NCI:C34873
has cross-reference: SNOMEDCT_US_2020_03_01:154369005
has cross-reference: UMLS_CUI:C0029291
alternative_term: psittacosis
has_obo_namespace: disease_ontology
id: DOID:11262
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

trachoma
type: Class
subclass of: commensal bacterial infectious disease
subclass of: eye disease
textual definition: A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.
imported from: doid.owl
has_alternative_id: DOID:13013
has_alternative_id: DOID:13264
has cross-reference: GARD:10374
has cross-reference: ICD10CM:A71
has cross-reference: ICD10CM:A71.0
has cross-reference: ICD10CM:A71.1
has cross-reference: ICD9CM:076
has cross-reference: ICD9CM:076.0
has cross-reference: ICD9CM:076.1
has cross-reference: MESH:D014141
has cross-reference: SNOMEDCT_US_2020_03_01:154367007
has cross-reference: SNOMEDCT_US_2020_03_01:29976007
has cross-reference: SNOMEDCT_US_2020_03_01:52812002
has cross-reference: UMLS_CUI:C0040592
has cross-reference: UMLS_CUI:C0153107
has cross-reference: UMLS_CUI:C0153108
alternative_term: active stage trachoma
alternative_term: trachoma dubium
has_obo_namespace: disease_ontology
id: DOID:11265
in subset: gram-negative bacterial infectious disease

Hantavirus hemorrhagic fever with renal syndrome
type: Class
subclass of: kidney disease
subclass of: DOID 934
textual definition: A viral infectious disease that is a hemorrhagic fever, located in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade orthohantavirus has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.
imported from: doid.owl
has cross-reference: ICD10CM:A98.5
has cross-reference: ICD9CM:078.6
has cross-reference: MESH:D006480
has cross-reference: NCI:C84753
has cross-reference: SNOMEDCT_US_2020_03_01:186701001
has cross-reference: UMLS_CUI:C0019101
alternative_term: HFRS
alternative_term: Hemorrhagic fever, Russian
alternative_term: Hemorrhagic nephrosonephritis
alternative_term: Puumala virus nephropathy
has_obo_namespace: disease_ontology
id: DOID:11266
in subset: NCIthesaurus
in subset: zoonotic infectious disease

keratomalacia
type: Class
subclass of: corneal degeneration
imported from: doid.owl
has cross-reference: GARD:6825
has cross-reference: ICD10CM:H18.44
has cross-reference: ICD9CM:371.45
has cross-reference: MESH:C536156
has cross-reference: SNOMEDCT_US_2020_03_01:85149007
has cross-reference: UMLS_CUI:C0152455
has_obo_namespace: disease_ontology
id: DOID:11267

chronic apical periodontitis
type: Class
subclass of: periapical periodontitis
imported from: doid.owl
has cross-reference: ICD10CM:K04.5
has cross-reference: ICD9CM:522.6
has cross-reference: SNOMEDCT_US_2020_03_01:718052004
has cross-reference: UMLS_CUI:C0392492
has_obo_namespace: disease_ontology
id: DOID:11269

Plummer's disease
type: Class
subclass of: hyperthyroidism
imported from: doid.owl
has cross-reference: ICD10CM:E05.2
has cross-reference: ICD9CM:242.3
has cross-reference: NCI:C35171
has cross-reference: SNOMEDCT_US_2020_03_01:57777000
has cross-reference: UMLS_CUI:C0342127
alternative_term: Plummer disease
alternative_term: Toxic nodular Goiter
alternative_term: Toxic nodular goiter
has_obo_namespace: disease_ontology
id: DOID:11277
in subset: NCIthesaurus

pituitary apoplexy
type: Class
subclass of: pituitary infarct
imported from: doid.owl
has cross-reference: MESH:D010899
has cross-reference: NCI:C26853
has cross-reference: SNOMEDCT_US_2020_03_01:237701005
has cross-reference: UMLS_CUI:C0032001
alternative_term: Pituitary apoplexy
has_obo_namespace: disease_ontology
id: DOID:1129
in subset: NCIthesaurus

arteriovenous malformation
type: Class
subclass of: hemangioma
textual definition: A hemangioma that is characterized by a configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system.
imported from: doid.owl
has cross-reference: ICD10CM:I77.0
has cross-reference: NCI:C2882
has cross-reference: SNOMEDCT_US_2020_03_01:403966009
has cross-reference: UMLS_CUI:C0334533
alternative_term: Arteriovenous hemangioma
alternative_term: Cirsoid aneurysm
alternative_term: Racemose Angioma
alternative_term: Racemose aneurysm
alternative_term: Racemose hemangioma
has_obo_namespace: disease_ontology
id: DOID:11294
in subset: NCIthesaurus

pituitary infarct
type: Class
subclass of: necrosis of pituitary
imported from: doid.owl
has cross-reference: NCI:C27117
has cross-reference: SNOMEDCT_US_2020_03_01:95830009
has cross-reference: UMLS_CUI:C0342405
alternative_term: Pituitary infarction
has_obo_namespace: disease_ontology
id: DOID:1130
in subset: NCIthesaurus

cercarial dermatitis
type: Class
subclass of: schistosomiasis
subclass of: skin disease
textual definition: A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has symptom skin reddening, has symptom skin itching, in the water or immediately after emerging and has symptom itchy, raised papules, occur within hours of infection.
imported from: doid.owl
has cross-reference: GARD:9747
has cross-reference: ICD10CM:B65.3
has cross-reference: ICD9CM:120.3
has cross-reference: NCI:C34457
has cross-reference: SNOMEDCT_US_2020_03_01:187115002
has cross-reference: UMLS_CUI:C0546996
alternative_term: Cutaneous schistosomiasis
alternative_term: Sea bather's eruption
has_obo_namespace: disease_ontology
id: DOID:11302
in subset: NCIthesaurus

Kyasanur forest disease
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted by Haemaphysalis spinigera tick bite. The infection has symptom fever, has symptom headache, has symptom stiffness of the neck, has symptom severe muscle pain, has symptom cough, has symptom dehydration, and has symptom bleeding problems.
imported from: doid.owl
has cross-reference: GARD:8257
has cross-reference: ICD10CM:A98.2
has cross-reference: ICD9CM:065.2
has cross-reference: MESH:D007733
has cross-reference: SNOMEDCT_US_2020_03_01:23097003
has cross-reference: UMLS_CUI:C0022810
has_obo_namespace: disease_ontology
id: DOID:11320
in subset: tick-borne infectious disease

erysipelas
type: Class
subclass of: dermatitis
imported from: doid.owl
has cross-reference: GARD:6370
has cross-reference: ICD10CM:A46
has cross-reference: ICD9CM:035
has cross-reference: MESH:D004886
has cross-reference: SNOMEDCT_US_2020_03_01:266005008
has cross-reference: UMLS_CUI:C0014733
has_obo_namespace: disease_ontology
id: DOID:11330
in subset: gram-positive bacterial infectious disease

sarcoidosis
type: Class
subclass of: hypersensitivity reaction type IV disease
textual definition: A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs.
imported from: doid.owl
has cross-reference: GARD:7607
has cross-reference: ICD10CM:D86
has cross-reference: ICD9CM:135
has cross-reference: MESH:D012507
has cross-reference: NCI:C34995
has cross-reference: ORDO:797
has cross-reference: SNOMEDCT_US_2020_03_01:154425004
has cross-reference: UMLS_CUI:C0036202
alternative_term: Boeck sarcoid
alternative_term: lymphogranulomatosis
has_obo_namespace: disease_ontology
id: DOID:11335
in subset: NCIthesaurus

rhinoscleroma
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.
imported from: doid.owl
has cross-reference: ICD9CM:040.1
has cross-reference: MESH:D012226
has cross-reference: SNOMEDCT_US_2020_03_01:72409005
has cross-reference: UMLS_CUI:C0035468
has_obo_namespace: disease_ontology
id: DOID:11336
in subset: gram-negative bacterial infectious disease

tetanus
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.
imported from: doid.owl
has cross-reference: GARD:5144
has cross-reference: ICD10CM:A35
has cross-reference: ICD9CM:037
has cross-reference: MESH:D013742
has cross-reference: NCI:C85185
has cross-reference: SNOMEDCT_US_2020_03_01:154312006
has cross-reference: UMLS_CUI:C0039614
alternative_term: Infection due to Clostridium tetani
alternative_term: clostridial tetanus
has_obo_namespace: disease_ontology
id: DOID:11338
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

pneumocystosis
type: Class
subclass of: opportunistic mycosis
subclass of: lung disease
textual definition: An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever.
imported from: doid.owl
has cross-reference: GARD:4386
has cross-reference: ICD10CM:B59
has cross-reference: ICD9CM:136.3
has cross-reference: MESH:D011020
has cross-reference: NCI:C3334
has cross-reference: SNOMEDCT_US_2020_03_01:57541005
has cross-reference: UMLS_CUI:C1535939
alternative_term: Pneumocystis carinii pneumonia
alternative_term: Pneumocystis jirovecii pneumonia
alternative_term: Pneumocystis pneumonia
alternative_term: Pneumocystosis
alternative_term: Pneumocystosis pneumonia
alternative_term: pulmonary pneumocystosis
has_obo_namespace: disease_ontology
id: DOID:11339
in subset: NCIthesaurus

gingival recession
type: Class
subclass of: gingival disease
imported from: doid.owl
has_alternative_id: DOID:1133
has_alternative_id: DOID:13280
has_alternative_id: DOID:13901
has_alternative_id: DOID:2405
has cross-reference: ICD10CM:K06.0
has cross-reference: ICD10CM:K06.01
has cross-reference: ICD9CM:523.2
has cross-reference: ICD9CM:523.24
has cross-reference: MESH:D005889
has cross-reference: NCI:C82068
has cross-reference: SNOMEDCT_US_2020_03_01:155645006
has cross-reference: SNOMEDCT_US_2020_03_01:59898000
has cross-reference: UMLS_CUI:C0017572
has cross-reference: UMLS_CUI:C0266916
alternative_term: Gingival recession
alternative_term: Gingival recession, localized
alternative_term: localized gingival recession
alternative_term: minimal gingival recession
alternative_term: moderate gingival recession
alternative_term: severe gingival recession
has_obo_namespace: disease_ontology
id: DOID:1134
in subset: NCIthesaurus

scleral disease
type: Class
subclass of: eye disease
textual definition: An eye disease that affects the sclera, which is the white fibrous outer layer of the eyeball.
imported from: doid.owl
has cross-reference: ICD10CM:H15
has cross-reference: MESH:D015422
has cross-reference: NCI:C79717
has cross-reference: SNOMEDCT_US_2020_03_01:33064008
has cross-reference: UMLS_CUI:C0036412
has_obo_namespace: disease_ontology
id: DOID:11343
in subset: NCIthesaurus

bladder diverticulum
type: Class
subclass of: bladder disease
imported from: doid.owl
has cross-reference: ICD10CM:N32.3
has cross-reference: ICD9CM:596.3
has cross-reference: MESH:C562406
has cross-reference: NCI:C160155
has cross-reference: OMIM:109820
has cross-reference: SNOMEDCT_US_2020_03_01:268335001
has cross-reference: UMLS_CUI:C0156273
alternative_term: Diverticulum - bladder
alternative_term: Diverticulum of bladder
has_obo_namespace: disease_ontology
id: DOID:11353
comment: OMIM mapping confirmed by DO. [SN].

Phlebotomus fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted by Phlebotomus papatasi sandfly. The infection has symptom fever, has symptom severe frontal headaches, has symptom muscle ache, has symptom joint aches, has symptom flushing of the face, and has symptom tachycardia.
imported from: doid.owl
has cross-reference: ICD10CM:A93.1
has cross-reference: ICD9CM:066.0
has cross-reference: MESH:D010217
has cross-reference: SNOMEDCT_US_2020_03_01:33670001
has cross-reference: UMLS_CUI:C0030372
alternative_term: Sandfly fever
alternative_term: Sandfly-borne arboviral fever
alternative_term: Sandfly-borne bunyavirus fever
alternative_term: Sandfly-borne phleboviral disease
alternative_term: pappataci fever
has_obo_namespace: disease_ontology
id: DOID:11360
in subset: zoonotic infectious disease

lens subluxation
type: Class
subclass of: lens disease
imported from: doid.owl
has cross-reference: ICD10CM:H27.11
has cross-reference: ICD9CM:379.32
has cross-reference: MESH:D007906
has cross-reference: NCI:C34772
has cross-reference: SNOMEDCT_US_2020_03_01:155203002
has cross-reference: UMLS_CUI:C0023316
alternative_term: Subluxation of lens
has_obo_namespace: disease_ontology
id: DOID:11364
in subset: NCIthesaurus

congenital aphakia
type: Class
subclass of: physical disorder
subclass of: lens disease
imported from: doid.owl
has cross-reference: ICD10CM:Q12.3
has cross-reference: ICD9CM:743.35
has cross-reference: NCI:C35172
has cross-reference: OMIM:610256
has cross-reference: SNOMEDCT_US_2020_03_01:35387008
has cross-reference: UMLS_CUI:C0152422
alternative_term: APHAKIA, CONGENITAL PRIMARY
alternative_term: Congenital absence of lens
has_obo_namespace: disease_ontology
id: DOID:11367
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

megacolon
type: Class
subclass of: colonic disease
textual definition: A colonic disease that is characterized by an abnormal dilation of the colon.
imported from: doid.owl
has_alternative_id: DOID:1771
has cross-reference: ICD10CM:K59.39
has cross-reference: MESH:D008531
has cross-reference: NCI:C34810
has cross-reference: SNOMEDCT_US_2020_03_01:33995003
has cross-reference: UMLS_CUI:C0025160
alternative_term: Dilatation of colon
has_obo_namespace: disease_ontology
id: DOID:11372
in subset: NCIthesaurus

gnathomiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis.
imported from: doid.owl
has cross-reference: GARD:9286
has cross-reference: ICD10CM:B83.1
has cross-reference: ICD9CM:128.1
has cross-reference: MESH:D058429
has cross-reference: NCI:C128395
has cross-reference: SNOMEDCT_US_2020_03_01:44086001
has cross-reference: UMLS_CUI:C0018013
alternative_term: Gnathostomiasis
alternative_term: Infectious Disease by Gnathostoma
has_obo_namespace: disease_ontology
id: DOID:11379
in subset: NCIthesaurus

spinal meningioma
type: Class
subclass of: spinal canal and spinal cord meningioma
subclass of: meningioma
imported from: doid.owl
has cross-reference: GARD:10264
has cross-reference: MESH:D008579
has cross-reference: NCI:C6935
has cross-reference: SNOMEDCT_US_2020_03_01:189167009
has cross-reference: UMLS_CUI:C0347515
alternative_term: Spinal Cord meningioma
alternative_term: Spinal meningioma
has_obo_namespace: disease_ontology
id: DOID:1138
in subset: NCIthesaurus

cryptorchidism
type: Class
subclass of: disorder of sexual development
imported from: doid.owl
has cross-reference: ICD10CM:Q53.9
has cross-reference: ICD9CM:752.51
has cross-reference: MESH:D003456
has cross-reference: NCI:C12326
has cross-reference: OMIM:219050
has cross-reference: SNOMEDCT_US_2020_03_01:204879009
has cross-reference: UMLS_CUI:C0010417
alternative_term: Cryptorchism
alternative_term: Undescended testicle
alternative_term: Undescended testis
alternative_term: undescended testicles
has_obo_namespace: disease_ontology
id: DOID:11383
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

expressive language disorder
type: Class
subclass of: DOID 93
textual definition: A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits.
imported from: doid.owl
has cross-reference: ICD10CM:F80.1
has cross-reference: ICD9CM:315.31
has cross-reference: NCI:C92562
has cross-reference: SNOMEDCT_US_2020_03_01:80360005
has cross-reference: UMLS_CUI:C0236826
alternative_term: Developmental expressive language disorder
has_obo_namespace: disease_ontology
id: DOID:11385
in subset: NCIthesaurus

epidural abscess
type: Class
subclass of: central nervous system disease
textual definition: A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges).
imported from: doid.owl
has cross-reference: MESH:D020802
has cross-reference: SNOMEDCT_US_2020_03_01:310671007
has cross-reference: UMLS_CUI:C0270629
alternative_term: abscess epidural
has_obo_namespace: disease_ontology
id: DOID:11387

cerebral arteritis
type: Class
subclass of: cerebrovascular disease
imported from: doid.owl
has cross-reference: ICD9CM:437.4
has cross-reference: SNOMEDCT_US_2020_03_01:28366008
has cross-reference: UMLS_CUI:C0007773
alternative_term: Cerebral arteritis
has_obo_namespace: disease_ontology
id: DOID:11390

adult respiratory distress syndrome
type: Class
subclass of: respiratory failure
textual definition: A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.
imported from: doid.owl
has cross-reference: GARD:5698
has cross-reference: ICD10CM:J80
has cross-reference: MESH:D012128
has cross-reference: NCI:C3353
has cross-reference: SNOMEDCT_US_2020_03_01:155627006
has cross-reference: UMLS_CUI:C0035222
alternative_term: ARDS
alternative_term: Non-cardiogenic pulmonary edema
alternative_term: Shock lung
alternative_term: acute respiratory distress syndrome
alternative_term: adult RDS
has_obo_namespace: disease_ontology
id: DOID:11394
in subset: NCIthesaurus
comment: PRISM.

heart disease
type: Class
subclass of: cardiovascular system disease
textual definition: A cardiovascular system disease that involves the heart.
imported from: doid.owl
has cross-reference: ICD10CM:I51.9
has cross-reference: ICD9CM:429.9
has cross-reference: MESH:D006331
has cross-reference: NCI:C3079
has cross-reference: SNOMEDCT_US_2020_03_01:194707003
has cross-reference: UMLS_CUI:C0018799
has_obo_namespace: disease_ontology
id: DOID:114
in subset: DO FlyBase slim
in subset: NCIthesaurus

spinal canal and spinal cord meningioma
type: Class
subclass of: spinal cancer
imported from: doid.owl
has cross-reference: NCI:C5134
has cross-reference: UMLS_CUI:C1334264
has_obo_namespace: disease_ontology
id: DOID:1140
in subset: NCIthesaurus

pyelonephritis
type: Class
subclass of: pyelitis
imported from: doid.owl
has cross-reference: ICD10CM:N16
has cross-reference: ICD9CM:590.80
has cross-reference: MESH:D011704
has cross-reference: NCI:C34965
has cross-reference: SNOMEDCT_US_2020_03_01:45816000
has cross-reference: UMLS_CUI:C0034186
has_obo_namespace: disease_ontology
id: DOID:11400
in subset: NCIthesaurus

xanthogranulomatous pyelonephritis
type: Class
subclass of: chronic pyelonephritis
imported from: doid.owl
has cross-reference: MESH:D011705
has cross-reference: NCI:C123038
has cross-reference: SNOMEDCT_US_2020_03_01:197777006
has cross-reference: UMLS_CUI:C0034188
alternative_term: Xanthogranulomatous pyelonephritis
has_obo_namespace: disease_ontology
id: DOID:11401
in subset: NCIthesaurus

diphtheria
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.
imported from: doid.owl
has_alternative_id: DOID:4132
has cross-reference: GARD:1875
has cross-reference: MESH:D003354
has cross-reference: SNOMEDCT_US_2020_03_01:397434007
has cross-reference: UMLS_CUI:C0010153
alternative_term: corynebacterium infection
has_obo_namespace: disease_ontology
id: DOID:11405
in subset: gram-positive bacterial infectious disease

endosalpingiosis
type: Class
subclass of: endometriosis
textual definition: A female reproductive system disease characterized by the growth of fallopian tube-like epithelium outside the fallopian tube.
imported from: doid.owl
has cross-reference: NCI:C40121
has cross-reference: SNOMEDCT_US_2020_03_01:55850004
has cross-reference: UMLS_CUI:C0269106
has_obo_namespace: disease_ontology
id: DOID:11427
in subset: NCIthesaurus

exotropia
type: Class
subclass of: strabismus
imported from: doid.owl
has cross-reference: ICD10CM:H50.1
has cross-reference: ICD9CM:378.1
has cross-reference: MESH:D005099
has cross-reference: NCI:C34601
has cross-reference: SNOMEDCT_US_2020_03_01:155194007
has cross-reference: UMLS_CUI:C0015310
alternative_term: Divergent Strabismus
alternative_term: Divergent concomitant strabismus
has_obo_namespace: disease_ontology
id: DOID:1143
in subset: NCIthesaurus

brain compression
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by pressure on the intracranial tissues by an effusion of blood or cerebrospinal fluid, an abscess, a neoplasm, a depressed fracture of the skull, or edema of the brain.
imported from: doid.owl
has cross-reference: ICD10CM:G93.5
has cross-reference: ICD9CM:348.4
has cross-reference: SNOMEDCT_US_2020_03_01:46963008
has cross-reference: UMLS_CUI:C0009592
has_obo_namespace: disease_ontology
id: DOID:11457

pseudotumor cerebri
type: Class
subclass of: DOID 9428
imported from: doid.owl
has cross-reference: GARD:4561
has cross-reference: ICD10CM:G93.2
has cross-reference: ICD9CM:348.2
has cross-reference: MESH:D011559
has cross-reference: NCI:C85035
has cross-reference: OMIM:243200
has cross-reference: SNOMEDCT_US_2020_03_01:68267002
has cross-reference: UMLS_CUI:C0033845
alternative_term: Pseudotumor cerebri
alternative_term: benign intracran. hypt.
alternative_term: benign intracranial hypertension
alternative_term: idiopathic intracranial hypertension
has_obo_namespace: disease_ontology
id: DOID:11459
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

autonomic nervous system disease
type: Class
subclass of: peripheral nervous system disease
imported from: doid.owl
has cross-reference: ICD9CM:337.1
has cross-reference: UMLS_CUI:C0154691
alternative_term: autonomic nervous system disorder
has_obo_namespace: disease_ontology
id: DOID:11465

osteoporosis
type: Class
subclass of: bone resorption disease
textual definition: A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.
imported from: doid.owl
has cross-reference: EFO:0003882
has cross-reference: ICD10CM:M81.0
has cross-reference: ICD9CM:733.0
has cross-reference: MESH:D010024
has cross-reference: NCI:C3298
has cross-reference: OMIM:166710
has cross-reference: SNOMEDCT_US_2020_03_01:156825006
has cross-reference: UMLS_CUI:C0029456
has_obo_namespace: disease_ontology
id: DOID:11476
in subset: NCIthesaurus
comment: Xref MGI.

polydactyly
type: Class
subclass of: physical disorder
textual definition: A physical disorder that is characterized by the presence of more than five fingers per hand or five toes per foot.
imported from: doid.owl
has_alternative_id: DOID:14779
has cross-reference: GARD:4410
has cross-reference: ICD10CM:Q69
has cross-reference: ICD9CM:755.0
has cross-reference: MESH:C562429
has cross-reference: MESH:D017689
has cross-reference: NCI:C87110
has cross-reference: OMIM:174200
has cross-reference: OMIM:174500
has cross-reference: OMIM:174700
has cross-reference: OMIM:603596
has cross-reference: SNOMEDCT_US_2020_03_01:205119005
has cross-reference: UMLS_CUI:C0152427
has cross-reference: UMLS_CUI:C0220697
alternative_term: postaxial polydactyly
has_obo_namespace: disease_ontology
has_related_synonym: Supernumerary digit
id: DOID:1148
in subset: NCIthesaurus

constrictive pericarditis
type: Class
subclass of: pericarditis
imported from: doid.owl
has cross-reference: ICD9CM:423.2
has cross-reference: MESH:D010494
has cross-reference: NCI:C78246
has cross-reference: SNOMEDCT_US_2020_03_01:155340008
has cross-reference: UMLS_CUI:C0031048
alternative_term: Constrictive pericarditis
has_obo_namespace: disease_ontology
id: DOID:11481
in subset: NCIthesaurus

hemopericardium
type: Class
subclass of: pericardial effusion
textual definition: A pericardial effusion that results from blood in the pericardial sac.
imported from: doid.owl
has cross-reference: ICD9CM:423.0
has cross-reference: MESH:D010490
has cross-reference: NCI:C111644
has cross-reference: SNOMEDCT_US_2020_03_01:155339006
has cross-reference: UMLS_CUI:C0019064
alternative_term: Haemopericardium
has_obo_namespace: disease_ontology
id: DOID:11482
in subset: NCIthesaurus

Horner's syndrome
type: Class
subclass of: autonomic neuropathy
imported from: doid.owl
has cross-reference: GARD:6670
has cross-reference: ICD10CM:G90.2
has cross-reference: MESH:D006732
has cross-reference: NCI:C28155
has cross-reference: OMIM:143000
has cross-reference: SNOMEDCT_US_2020_03_01:192922002
has cross-reference: UMLS_CUI:C0019937
alternative_term: Bernard Horner syndrome
alternative_term: Horner syndrome
alternative_term: cervical sympathetic paralysis
has_obo_namespace: disease_ontology
id: DOID:11486
in subset: NCIthesaurus

cardiac tamponade
type: Class
subclass of: pericardial effusion
textual definition: A pericardial effusion in which fluid accumulates in the pericardium (the sac in which the heart is enclosed) and the pericardial spaces fills up faster than the pericardial sac can stretch.
imported from: doid.owl
has cross-reference: ICD10CM:I31.4
has cross-reference: ICD9CM:423.3
has cross-reference: MESH:D002305
has cross-reference: NCI:C50481
has cross-reference: SNOMEDCT_US_2020_03_01:266295005
has cross-reference: UMLS_CUI:C0007177
alternative_term: Rose's tamponade
alternative_term: pericardial tamponade
has_obo_namespace: disease_ontology
id: DOID:115
in subset: NCIthesaurus

mitral valve insufficiency
type: Class
subclass of: mitral valve disease
imported from: doid.owl
has_alternative_id: DOID:11737
has_alternative_id: DOID:13947
has cross-reference: ICD10CM:Q23.3
has cross-reference: ICD9CM:396.3
has cross-reference: ICD9CM:746.6
has cross-reference: MESH:D008944
has cross-reference: NCI:C50888
has cross-reference: SNOMEDCT_US_2020_03_01:194736003
has cross-reference: SNOMEDCT_US_2020_03_01:194977007
has cross-reference: SNOMEDCT_US_2020_03_01:29928006
has cross-reference: UMLS_CUI:C0026266
has cross-reference: UMLS_CUI:C0158619
has cross-reference: UMLS_CUI:C0264774
alternative_term: Congenital insufficiency of mitral valve
alternative_term: Mitral valve incompetence
alternative_term: congenital mitral insufficiency
alternative_term: congenital mitral regurgitation
alternative_term: mitral regurgitation
has_obo_namespace: disease_ontology
id: DOID:11502
in subset: NCIthesaurus

autonomic neuropathy
type: Class
subclass of: autonomic nervous system disease
imported from: doid.owl
has cross-reference: NCI:C27033
has cross-reference: SNOMEDCT_US_2020_03_01:277879009
has cross-reference: UMLS_CUI:C0259749
has_obo_namespace: disease_ontology
id: DOID:11504
in subset: NCIthesaurus

suppurative otitis media
type: Class
subclass of: otitis media
textual definition: A otitis media which involves inflammation of the middle ear with infected effusion containing pus.
imported from: doid.owl
has cross-reference: ICD10CM:H66.4
has cross-reference: ICD9CM:382.4
has cross-reference: MESH:D010035
has cross-reference: SNOMEDCT_US_2020_03_01:267758003
has cross-reference: UMLS_CUI:C0029888
alternative_term: Otitis media with effusion - purulent
alternative_term: Purulent otitis media
has_obo_namespace: disease_ontology
id: DOID:11506

Budd-Chiari syndrome
type: Class
subclass of: hepatic vascular disease
imported from: doid.owl
has cross-reference: ICD10CM:I82.0
has cross-reference: MESH:D006502
has cross-reference: OMIM:600880
has cross-reference: SNOMEDCT_US_2020_03_01:195436007
has cross-reference: UMLS_CUI:C0019154
alternative_term: hepatic vein thrombosis
has_obo_namespace: disease_ontology
id: DOID:11512

fissured tongue
type: Class
subclass of: tongue disease
imported from: doid.owl
has cross-reference: ICD10CM:K14.5
has cross-reference: ICD9CM:529.5
has cross-reference: MESH:D014063
has cross-reference: OMIM:137400
has cross-reference: SNOMEDCT_US_2020_03_01:52368004
has cross-reference: UMLS_CUI:C0040412
alternative_term: Congenital fissure of tongue
alternative_term: Congenital plicated tongue
alternative_term: Fissure of tongue
alternative_term: Fissure of tongue, congenital
alternative_term: Furrowed tongue
alternative_term: Plicated tongue
alternative_term: Tongue, Fissured
alternative_term: geographic tongue and fissured tongue
alternative_term: lingua plicata
alternative_term: scrotal tongue
has_obo_namespace: disease_ontology
id: DOID:11514
comment: OMIM mapping confirmed by DO. [SN].

hypertensive heart disease
type: Class
subclass of: heart disease
textual definition: A heart disease that is caused by high blood pressure.
imported from: doid.owl
has cross-reference: ICD10CM:I11
has cross-reference: ICD9CM:402
has cross-reference: NCI:C157879
has cross-reference: SNOMEDCT_US_2020_03_01:155297007
has cross-reference: UMLS_CUI:C0152105
has_obo_namespace: disease_ontology
id: DOID:11516

laryngostenosis
type: Class
subclass of: laryngeal disease
imported from: doid.owl
has cross-reference: ICD10CM:J38.6
has cross-reference: ICD9CM:478.74
has cross-reference: MESH:D007829
has cross-reference: NCI:C79608
has cross-reference: SNOMEDCT_US_2020_03_01:195864007
has cross-reference: UMLS_CUI:C0023075
alternative_term: Stenosis of larynx
has_obo_namespace: disease_ontology
id: DOID:11527
in subset: NCIthesaurus

recurrent corneal erosion
type: Class
subclass of: corneal degeneration
imported from: doid.owl
has cross-reference: ICD10CM:H18.83
has cross-reference: ICD9CM:371.42
has cross-reference: SNOMEDCT_US_2020_03_01:2055003
has cross-reference: UMLS_CUI:C0155119
alternative_term: recurrent erosion of cornea
alternative_term: recurrent erosion syndrome
has_obo_namespace: disease_ontology
id: DOID:11541

corneal abscess
type: Class
subclass of: DOID 9858
imported from: doid.owl
has cross-reference: ICD10CM:H16.31
has cross-reference: ICD9CM:370.55
has cross-reference: NCI:C26969
has cross-reference: SNOMEDCT_US_2020_03_01:64366002
has cross-reference: UMLS_CUI:C0155091
has_obo_namespace: disease_ontology
id: DOID:11543
in subset: NCIthesaurus

Fuchs' endothelial dystrophy
type: Class
subclass of: corneal endothelial dystrophy
textual definition: A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.
imported from: doid.owl
has cross-reference: EFO:0003946
has cross-reference: GARD:10018
has cross-reference: ICD10CM:H18.51
has cross-reference: MESH:D005642
has cross-reference: NCI:C84721
has cross-reference: OMIM:136800
has cross-reference: OMIM:610158
has cross-reference: OMIM:613267
has cross-reference: OMIM:613268
has cross-reference: OMIM:613269
has cross-reference: OMIM:613270
has cross-reference: OMIM:613271
has cross-reference: OMIM:615523
has cross-reference: ORDO:98974
has cross-reference: SNOMEDCT_US_2020_03_01:16949007
has cross-reference: UMLS_CUI:C0016781
alternative_term: FCED
alternative_term: Fuchs' corneal dystrophy
alternative_term: Fuchs' endothelial corneal dystrophy
has_obo_namespace: disease_ontology
id: DOID:11555
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

chondrocalcinosis
type: Class
subclass of: arthritis
textual definition: An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint.
imported from: doid.owl
has_alternative_id: DOID:11303
has_alternative_id: DOID:1155
has_alternative_id: DOID:12090
has_alternative_id: DOID:12102
has_alternative_id: DOID:12945
has_alternative_id: DOID:13298
has_alternative_id: DOID:13299
has_alternative_id: DOID:13301
has_alternative_id: DOID:13302
has_alternative_id: DOID:13303
has_alternative_id: DOID:13304
has_alternative_id: DOID:14143
has_alternative_id: DOID:14220
has_alternative_id: DOID:14513
has_alternative_id: DOID:1834
has_alternative_id: DOID:1945
has_alternative_id: DOID:2486
has cross-reference: ICD9CM:712.1
has cross-reference: NCI:C34955
has cross-reference: OMIM:118600
has cross-reference: OMIM:118610
has cross-reference: OMIM:600668
has cross-reference: ORDO:1416
has cross-reference: SNOMEDCT_US_2020_03_01:201624004
has cross-reference: SNOMEDCT_US_2020_03_01:201625003
has cross-reference: UMLS_CUI:C0033802
has cross-reference: UMLS_CUI:C0157852
alternative_term: calcium pyrophosphate deposition disease
alternative_term: pseudogout
has_obo_namespace: disease_ontology
id: DOID:1156
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

hypertensive retinopathy
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: ICD10CM:H35.03
has cross-reference: ICD9CM:362.11
has cross-reference: MESH:D058437
has cross-reference: NCI:C3514
has cross-reference: SNOMEDCT_US_2020_03_01:422001004
has cross-reference: UMLS_CUI:C0152132
has_obo_namespace: disease_ontology
id: DOID:11561
in subset: NCIthesaurus

neurocirculatory asthenia
type: Class
subclass of: somatoform disorder
textual definition: A somatoform disorder that involves heart disease symptoms without any identifiable physiological abnormatlities.
imported from: doid.owl
has cross-reference: ICD9CM:306.2
has cross-reference: MESH:D009449
has cross-reference: SNOMEDCT_US_2020_03_01:46219009
has cross-reference: UMLS_CUI:C0027821
alternative_term: Cardiovascular malfunction arising from mental factors
alternative_term: Cardiovascular neurosis
alternative_term: Da Costa's syndrome
alternative_term: Krishaber's disease
has_obo_namespace: disease_ontology
id: DOID:11569

listeriosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.
imported from: doid.owl
has cross-reference: ICD10CM:A32
has cross-reference: ICD9CM:027.0
has cross-reference: MESH:D008088
has cross-reference: NCI:C82994
has cross-reference: SNOMEDCT_US_2020_03_01:186315001
has cross-reference: UMLS_CUI:C0023860
alternative_term: Infection by Listeria monocytogenes
alternative_term: Listeria infection
has_obo_namespace: disease_ontology
id: DOID:11573
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease
in subset: zoonotic infectious disease

Cauda equina syndrome
type: Class
subclass of: syndrome
subclass of: peripheral nervous system disease
textual definition: A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord.
imported from: doid.owl
has cross-reference: GARD:10987
has cross-reference: ICD10CM:G83.4
has cross-reference: ICD9CM:344.6
has cross-reference: MESH:D000077684
has cross-reference: NCI:C35436
has cross-reference: SNOMEDCT_US_2020_03_01:89356000
has cross-reference: UMLS_CUI:C0392548
has_obo_namespace: disease_ontology
id: DOID:11577
in subset: NCIthesaurus

phlyctenulosis
type: Class
subclass of: DOID 9368
imported from: doid.owl
has cross-reference: ICD10CM:H16.25
has cross-reference: ICD9CM:370.31
has cross-reference: SNOMEDCT_US_2020_03_01:193773009
has cross-reference: UMLS_CUI:C0155080
alternative_term: Phlyctenular keratoconjunctivitis
alternative_term: Strumous ophthalmia
has_obo_namespace: disease_ontology
id: DOID:11581

Riley-Day syndrome
type: Class
subclass of: hereditary sensory neuropathy
imported from: doid.owl
has cross-reference: ICD10CM:G90.1
has cross-reference: MESH:D004402
has cross-reference: NCI:C84706
has cross-reference: OMIM:223900
has cross-reference: SNOMEDCT_US_2020_03_01:204087006
has cross-reference: UMLS_CUI:C0013364
alternative_term: HSAN III
alternative_term: familial autonomic nervous dysfunction
alternative_term: familial dysautonomia
has_obo_namespace: disease_ontology
id: DOID:11589
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

functional gastric disease
type: Class
subclass of: stomach disease
imported from: doid.owl
has cross-reference: ICD9CM:536.8
has cross-reference: UMLS_CUI:C0013396
has_obo_namespace: disease_ontology
id: DOID:1159

scleral staphyloma
type: Class
subclass of: scleral disease
imported from: doid.owl
has cross-reference: ICD10CM:H15.84
has cross-reference: ICD9CM:379.11
has cross-reference: SNOMEDCT_US_2020_03_01:111534007
has cross-reference: UMLS_CUI:C0155359
alternative_term: Scleral ectasia
has_obo_namespace: disease_ontology
id: DOID:11595

Frey syndrome
type: Class
subclass of: autonomic nervous system disease
imported from: doid.owl
has cross-reference: GARD:6467
has cross-reference: MESH:D013547
has cross-reference: OMIM:144100
has cross-reference: SNOMEDCT_US_2020_03_01:56046002
has cross-reference: UMLS_CUI:C0038994
alternative_term: Baillarger syndrome
alternative_term: gustatory hyperhidrosis
alternative_term: gustatory sweating
has_obo_namespace: disease_ontology
id: DOID:11599
comment: OMIM mapping confirmed by DO. [SN].

pericardium cancer
type: Class
subclass of: pericardium disease
subclass of: heart cancer
imported from: doid.owl
has_alternative_id: DOID:5780
has cross-reference: ICD10CM:C38.0
has cross-reference: NCI:C4567
has cross-reference: NCI:C4651
has cross-reference: SNOMEDCT_US_2020_03_01:126734005
has cross-reference: SNOMEDCT_US_2020_03_01:93957005
has cross-reference: UMLS_CUI:C0346609
has cross-reference: UMLS_CUI:C0349574
alternative_term: Pericardial tumor
alternative_term: malignant neoplasm of pericardium
alternative_term: malignant tumor of Pericardium
has_obo_namespace: disease_ontology
id: DOID:116
in subset: NCIthesaurus

fungal meningitis
type: Class
subclass of: fungal infectious disease
subclass of: DOID 9471
textual definition: A meningitis that has_material_basis_in a fungal infection.
imported from: doid.owl
has cross-reference: MESH:D016921
has cross-reference: SNOMEDCT_US_2020_03_01:24321005
has cross-reference: UMLS_CUI:C0085438
has_obo_namespace: disease_ontology
id: DOID:11608

polycystic ovary syndrome
type: Class
subclass of: ovarian dysfunction
textual definition: An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.
imported from: doid.owl
has cross-reference: EFO:0000660
has cross-reference: ICD10CM:E28.2
has cross-reference: ICD9CM:256.4
has cross-reference: MESH:D011085
has cross-reference: NCI:C26862
has cross-reference: OMIM:184700
has cross-reference: SNOMEDCT_US_2020_03_01:69878008
has cross-reference: UMLS_CUI:C0032460
alternative_term: Multicystic ovaries
alternative_term: PCOS
alternative_term: Polycystic Ovarian disease
alternative_term: Polycystic ovaries
alternative_term: Polycystic ovary syndrome
alternative_term: Stein-Leventhal synd.
alternative_term: Stein-Leventhal syndrome
alternative_term: polycystic ovary
has_obo_namespace: disease_ontology
id: DOID:11612
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hyperandrogenism
type: Class
subclass of: disorder of sexual development
imported from: doid.owl
has cross-reference: MESH:D017588
has cross-reference: SNOMEDCT_US_2020_03_01:237793004
has cross-reference: UMLS_CUI:C0206081
alternative_term: hyperandrogenization syndrome
has_obo_namespace: disease_ontology
id: DOID:11613

penile cancer
type: Class
subclass of: penile disease
subclass of: male reproductive organ cancer
imported from: doid.owl
has_alternative_id: DOID:11614
has cross-reference: ICD10CM:C60
has cross-reference: ICD10CM:C60.2
has cross-reference: ICD9CM:187.3
has cross-reference: ICD9CM:187.4
has cross-reference: MESH:D010412
has cross-reference: NCI:C7547
has cross-reference: SNOMEDCT_US_2020_03_01:93716006
has cross-reference: SNOMEDCT_US_2020_03_01:93954003
has cross-reference: UMLS_CUI:C0153600
has cross-reference: UMLS_CUI:C0153601
alternative_term: Ca penis
alternative_term: Penile Ca
alternative_term: malignant Penile tumor
alternative_term: malignant neoplasm of body of penis
alternative_term: penile neoplasm
has_obo_namespace: disease_ontology
id: DOID:11615
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

dental pulp necrosis
type: Class
subclass of: dental pulp disease
imported from: doid.owl
has cross-reference: ICD10CM:K04.1
has cross-reference: ICD9CM:522.1
has cross-reference: MESH:D003790
has cross-reference: SNOMEDCT_US_2020_03_01:196332000
has cross-reference: UMLS_CUI:C0011407
alternative_term: necrosis of the pulp
alternative_term: necrotic pulp
alternative_term: pulp necrosis
has_obo_namespace: disease_ontology
id: DOID:11623

penile benign neoplasm
type: Class
subclass of: male reproductive organ benign neoplasm
subclass of: penile disease
imported from: doid.owl
has cross-reference: MESH:D010412
has cross-reference: NCI:C3317
has cross-reference: SNOMEDCT_US_2020_03_01:126896003
has cross-reference: UMLS_CUI:C0030849
alternative_term: Penile tumor
alternative_term: neoplasm of penis
has_obo_namespace: disease_ontology
id: DOID:11624
in subset: NCIthesaurus

thyroid hormone resistance syndrome
type: Class
subclass of: hypothyroidism
imported from: doid.owl
has cross-reference: MESH:D018382
has cross-reference: NCI:C85191
has cross-reference: OMIM:188570
has cross-reference: OMIM:274300
has cross-reference: SNOMEDCT_US_2020_03_01:50375007
has cross-reference: UMLS_CUI:C2940786
alternative_term: Generalized thyroid hormone resistance
alternative_term: Refetoff syndrome
alternative_term: Thyroid hormone resistance syndrome
alternative_term: Thyroid hormone responsiveness defect
alternative_term: thyroid hormone resistance
has_obo_namespace: disease_ontology
id: DOID:11633
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

presbyopia
type: Class
subclass of: eye accommodation disease
imported from: doid.owl
has cross-reference: ICD10CM:H52.4
has cross-reference: ICD9CM:367.4
has cross-reference: MESH:D011305
has cross-reference: SNOMEDCT_US_2020_03_01:155135005
has cross-reference: UMLS_CUI:C0033075
has_obo_namespace: disease_ontology
id: DOID:11638

cicatricial pemphigoid
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: bullous skin disease
textual definition: A bullous skin disease characterized by skin lesions and scaring and located_in mucous membranes and located_in skin.
imported from: doid.owl
has_alternative_id: DOID:11655
has cross-reference: GARD:5913
has cross-reference: ICD10CM:L12.1
has cross-reference: ICD9CM:694.6
has cross-reference: ICD9CM:694.61
has cross-reference: MESH:D010390
has cross-reference: NCI:C34907
has cross-reference: OMIM:164185
has cross-reference: SNOMEDCT_US_2020_03_01:34250006
has cross-reference: SNOMEDCT_US_2020_03_01:76092003
has cross-reference: UMLS_CUI:C0030804
has cross-reference: UMLS_CUI:C0157721
alternative_term: Cicatricial pemphigoid with ocular involvement
alternative_term: Ocular pemphigoid
alternative_term: benign mucous membrane pemphigoid
alternative_term: benign mucous membrane pemphigoid with ocular involvement
alternative_term: ocular pemphigus
has_obo_namespace: disease_ontology
id: DOID:11656
in subset: NCIthesaurus

palindromic rheumatism
type: Class
subclass of: arthritis
textual definition: An arthritis that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.
imported from: doid.owl
has_alternative_id: DOID:1165
has_alternative_id: DOID:1177
has_alternative_id: DOID:1178
has_alternative_id: DOID:1179
has_alternative_id: DOID:12951
has_alternative_id: DOID:13354
has_alternative_id: DOID:13355
has_alternative_id: DOID:13771
has cross-reference: GARD:7304
has cross-reference: ICD10CM:M12.3
has cross-reference: ICD9CM:719.3
has cross-reference: ICD9CM:719.31
has cross-reference: MESH:C538103
has cross-reference: SNOMEDCT_US_2020_03_01:202455001
has cross-reference: SNOMEDCT_US_2020_03_01:202457009
has cross-reference: UMLS_CUI:C0085574
has cross-reference: UMLS_CUI:C0158178
alternative_term: Hench's syndrome
alternative_term: Hench-Rosenberg syndrome
has_obo_namespace: disease_ontology
id: DOID:1166

blue color blindness
type: Class
subclass of: autosomal dominant disease
subclass of: color blindness
textual definition: A color blindness that is characterised by a selective deficiency of blue vision, has_material_basis_in autosomal dominant inheritance of a mutation in the OPN1SW gene and is associated with a deficiency or absence of blue-sensitive cone photoreceptor function.
imported from: doid.owl
has cross-reference: ICD10CM:H53.55
has cross-reference: ICD9CM:368.53
has cross-reference: MESH:D003117
has cross-reference: OMIM:190900
has cross-reference: SNOMEDCT_US_2020_03_01:51886007
has cross-reference: UMLS_CUI:C0155017
alternative_term: Tritan defect
alternative_term: Tritanopia
has_obo_namespace: disease_ontology
id: DOID:11661
comment: OMIM mapping confirmed by DO. [SN].

Patau syndrome
type: Class
subclass of: chromosomal disease
imported from: doid.owl
has cross-reference: ICD10CM:Q91.7
has cross-reference: ICD9CM:758.1
has cross-reference: MESH:D000073839
has cross-reference: NCI:C101223
has cross-reference: SNOMEDCT_US_2020_03_01:21111006
has cross-reference: UMLS_CUI:C0152095
alternative_term: D1 Trisomy
alternative_term: trisomy 13
has_obo_namespace: disease_ontology
has_related_synonym: Patau's syndrome
id: DOID:11665
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

onchocerciasis
type: Class
subclass of: filariasis
textual definition: A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.
imported from: doid.owl
has cross-reference: GARD:7252
has cross-reference: ICD10CM:B73
has cross-reference: ICD9CM:125.3
has cross-reference: MESH:D009855
has cross-reference: NCI:C34861
has cross-reference: SNOMEDCT_US_2020_03_01:38539003
has cross-reference: UMLS_CUI:C0029001
alternative_term: Infection by Onchocerca volvulus
alternative_term: Onchocerca volvulus infection
alternative_term: volvulosis
has_obo_namespace: disease_ontology
id: DOID:11678
in subset: NCIthesaurus

familial hyperlipidemia
type: Class
subclass of: lipid metabolism disorder
imported from: doid.owl
has_alternative_id: DOID:3147
has cross-reference: ICD10CM:E78.5
has cross-reference: MESH:D006949
has cross-reference: MESH:D006951
has cross-reference: NCI:C34707
has cross-reference: NCI:C34709
has cross-reference: SNOMEDCT_US_2020_03_01:154739000
has cross-reference: SNOMEDCT_US_2020_03_01:3744001
has cross-reference: UMLS_CUI:C0020473
has cross-reference: UMLS_CUI:C0020476
alternative_term: familial hyperlipoproteinemia
alternative_term: hyperlipemia
has_obo_namespace: disease_ontology
has_related_synonym: hyperlipidaemia
id: DOID:1168
in subset: NCIthesaurus

melanoacanthoma
type: Class
subclass of: seborrheic keratosis
imported from: doid.owl
has cross-reference: NCI:C27548
has cross-reference: SNOMEDCT_US_2020_03_01:201096007
has cross-reference: UMLS_CUI:C1321683
has_obo_namespace: disease_ontology
id: DOID:11684
in subset: NCIthesaurus

acute apical periodontitis
type: Class
subclass of: periapical periodontitis
imported from: doid.owl
has cross-reference: ICD10CM:K04.4
has cross-reference: ICD9CM:522.4
has cross-reference: SNOMEDCT_US_2020_03_01:88071000
has cross-reference: UMLS_CUI:C0155934
alternative_term: acute apical periodontitis of pulpal origin
has_obo_namespace: disease_ontology
id: DOID:11693

portal vein thrombosis
type: Class
subclass of: thrombosis
subclass of: hepatic vascular disease
subclass of: DOID 866
textual definition: A hepatic vascular disease that is characterized by a blood clot that forms within the hepatic portal vein.
imported from: doid.owl
has cross-reference: ICD10CM:I81
has cross-reference: ICD9CM:452
has cross-reference: NCI:C78565
has cross-reference: SNOMEDCT_US_2020_03_01:155455003
has cross-reference: UMLS_CUI:C0155773
has_obo_namespace: disease_ontology
id: DOID:11695
in subset: NCIthesaurus

heart cancer
type: Class
subclass of: heart disease
subclass of: cardiovascular cancer
textual definition: A cardiovascular cancer located_in the heart.
imported from: doid.owl
has_alternative_id: DOID:9918
has cross-reference: GARD:2619
has cross-reference: ICD10CM:C38.0
has cross-reference: ICD9CM:164.1
has cross-reference: MESH:D006338
has cross-reference: NCI:C3081
has cross-reference: NCI:C3548
has cross-reference: SNOMEDCT_US_2020_03_01:126730001
has cross-reference: SNOMEDCT_US_2020_03_01:93825008
has cross-reference: UMLS_CUI:C0018809
has cross-reference: UMLS_CUI:C0153500
alternative_term: Cardiac tumor
alternative_term: Tumour of heart
alternative_term: malignant Cardiac tumor
alternative_term: malignant neoplasm of heart
has_obo_namespace: disease_ontology
id: DOID:117
in subset: NCIthesaurus

dysgammaglobulinemia
type: Class
subclass of: selective immunoglobulin deficiency disease
textual definition: A selective immunoglobulin deficiency disease that is caused by a reduction in some types of gamma globulins.
imported from: doid.owl
has cross-reference: MESH:D004406
has cross-reference: SNOMEDCT_US_2020_03_01:127389001
has cross-reference: UMLS_CUI:C0013374
alternative_term: Dysgammaglobulinemia
has_obo_namespace: disease_ontology
id: DOID:11702

diabetic angiopathy
type: Class
subclass of: peripheral vascular disease
textual definition: A peripheral vascular disease that is characterized by narrowing of the arteries as a complication arising from chronic diabetes.
imported from: doid.owl
has_alternative_id: DOID:10182
has cross-reference: ICD9CM:250.7
has cross-reference: MESH:D003925
has cross-reference: NCI:C35610
has cross-reference: SNOMEDCT_US_2020_03_01:127014009
has cross-reference: UMLS_CUI:C0011871
has cross-reference: UMLS_CUI:C0011875
alternative_term: Diabetic vascular disorder
alternative_term: diabetic peripheral angiopathy
has_obo_namespace: disease_ontology
id: DOID:11713
in subset: NCIthesaurus

gestational diabetes
type: Class
subclass of: DOID 9351
textual definition: A diabetes mellitus that manifests during pregnancy.
imported from: doid.owl
has cross-reference: EFO:0004593
has cross-reference: ICD10CM:O24.4
has cross-reference: MESH:D016640
has cross-reference: NCI:C34942
has cross-reference: SNOMEDCT_US_2020_03_01:11687002
has cross-reference: UMLS_CUI:C0085207
alternative_term: GDM
alternative_term: Gestational diabetes mellitus
alternative_term: Maternal gestational diabetes mellitus
has_obo_namespace: disease_ontology
id: DOID:11714
in subset: NCIthesaurus

prediabetes syndrome
type: Class
subclass of: glucose metabolism disease
textual definition: A glucose metabolism disease that is characterized by blood glucose levels are high, but not high enough to be classified as type 2 diabetes.
imported from: doid.owl
has cross-reference: ICD10CM:R73.03
has cross-reference: MESH:D011236
has cross-reference: NCI:C122685
has cross-reference: SNOMEDCT_US_2020_03_01:15777000
has cross-reference: UMLS_CUI:C0362046
alternative_term: Prediabetes
alternative_term: impaired glucose tolerance
alternative_term: prediabetic state
has_obo_namespace: disease_ontology
id: DOID:11716
in subset: NCIthesaurus

neonatal diabetes
type: Class
subclass of: DOID 9351
textual definition: A diabetes mellitus that is characterized by hyperglycemia occuring within the first 6 months of life.
imported from: doid.owl
has cross-reference: ICD10CM:P70.2
has cross-reference: ICD9CM:775.1
has cross-reference: NCI:C99248
has cross-reference: SNOMEDCT_US_2020_03_01:49817004
has cross-reference: UMLS_CUI:C0158981
alternative_term: diabetes mellitus syndrome in newborn infant
alternative_term: neonatal diabetes mellitus
has_obo_namespace: disease_ontology
id: DOID:11717
in subset: DO FlyBase slim
in subset: NCIthesaurus

hyperlipoproteinemia type IV
type: Class
subclass of: familial hyperlipidemia
imported from: doid.owl
has_alternative_id: DOID:0050527
has cross-reference: ICD10CM:E78.1
has cross-reference: ICD9CM:272.1
has cross-reference: MESH:D006953
has cross-reference: NCI:C34711
has cross-reference: OMIM:144600
has cross-reference: OMIM:145750
has cross-reference: SNOMEDCT_US_2020_03_01:154741004
has cross-reference: UMLS_CUI:C0020480
alternative_term: Endogenous hyperlipidaemia
alternative_term: Fredrickson type IV Lipidemia
alternative_term: Fredrickson type IV hyperlipoproteinemia
alternative_term: Fredrickson type IV lipidaemia
alternative_term: VLDL hyperlipoproteinemia
alternative_term: familial hypertriglyceridemia
has_obo_namespace: disease_ontology
id: DOID:1172
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

distal myopathy
type: Class
subclass of: DOID 9884
textual definition: A muscular dystrophy that is characterized by predominant weakness and atrophy beginning in the feet and/or hands.
imported from: doid.owl
has cross-reference: ICD10CM:G71.09
has cross-reference: MESH:D049310
has cross-reference: NCI:C84675
has cross-reference: ORDO:399096
has cross-reference: ORDO:5448
has cross-reference: ORDO:59135
has cross-reference: SNOMEDCT_US_2020_03_01:58795000
has cross-reference: UMLS_CUI:C0751336
alternative_term: Miyoshi muscular dystrophy
alternative_term: distal muscular dystrophy
has_obo_namespace: disease_ontology
id: DOID:11720
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

myotonic dystrophy type 1
type: Class
subclass of: myotonic disease
textual definition: A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_material_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region.
imported from: doid.owl
has cross-reference: GARD:8310
has cross-reference: ICD10CM:G71.11
has cross-reference: ICD9CM:359.21
has cross-reference: MESH:D009223
has cross-reference: NCI:C84914
has cross-reference: OMIM:160900
has cross-reference: SNOMEDCT_US_2020_03_01:77956009
has cross-reference: UMLS_CUI:C0027126
alternative_term: Dystrophia myotonica
alternative_term: Steinert disease
alternative_term: congenital myotonic dystrophy
alternative_term: myotonic dystrophy of Steinert
has_obo_namespace: disease_ontology
id: DOID:11722
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Duchenne muscular dystrophy
type: Class
subclass of: X-linked recessive disease
subclass of: DOID 9884
textual definition: A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.
imported from: doid.owl
has cross-reference: GARD:6291
has cross-reference: MESH:D020388
has cross-reference: NCI:C75482
has cross-reference: OMIM:310200
has cross-reference: SNOMEDCT_US_2020_03_01:155095006
has cross-reference: UMLS_CUI:C0013264
alternative_term: Muscular dystrophy, Duchenne
has_obo_namespace: disease_ontology
id: DOID:11723
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

limb-girdle muscular dystrophy
type: Class
subclass of: DOID 9884
textual definition: A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles.
imported from: doid.owl
has cross-reference: GARD:6907
has cross-reference: ICD10CM:G71.09
has cross-reference: MESH:D049288
has cross-reference: NCI:C84828
has cross-reference: ORDO:263
has cross-reference: SNOMEDCT_US_2020_03_01:56096001
has cross-reference: UMLS_CUI:C0686353
alternative_term: Erb's muscular dystrophy
alternative_term: Leyden-Mbius muscular dystrophy
alternative_term: limb girdle muscular dystrophy
has_obo_namespace: disease_ontology
id: DOID:11724
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Cornelia de Lange syndrome
type: Class
subclass of: monogenic disease
subclass of: syndrome
textual definition: A syndrome that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features.
imported from: doid.owl
has cross-reference: GARD:10109
has cross-reference: ICD10CM:Q87.19
has cross-reference: MESH:D003635
has cross-reference: NCI:C75016
has cross-reference: OMIM:PS122470
has cross-reference: ORDO:199
has cross-reference: SNOMEDCT_US_2020_03_01:40354009
has cross-reference: UMLS_CUI:C0270972
alternative_term: Brachmann de Lange syndrome
alternative_term: De Lange syndrome
has_obo_namespace: disease_ontology
id: DOID:11725
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Emery-Dreifuss muscular dystrophy
type: Class
subclass of: DOID 9884
textual definition: A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle.
imported from: doid.owl
has cross-reference: GARD:6329
has cross-reference: MESH:D020389
has cross-reference: NCI:C84685
has cross-reference: OMIM:PS310300
has cross-reference: ORDO:261
has cross-reference: SNOMEDCT_US_2020_03_01:129620000
has cross-reference: UMLS_CUI:C0410189
alternative_term: EDMD
has_obo_namespace: disease_ontology
id: DOID:11726
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

facioscapulohumeral muscular dystrophy
type: Class
subclass of: DOID 9884
imported from: doid.owl
has cross-reference: GARD:9941
has cross-reference: ICD10CM:G71.02
has cross-reference: MESH:D020391
has cross-reference: NCI:C84704
has cross-reference: SNOMEDCT_US_2020_03_01:56096001
has cross-reference: UMLS_CUI:C0238288
alternative_term: Landouzy Dejerine muscular dystrophy
alternative_term: Landouzy-Dejerine muscular dystrophy
alternative_term: Muscular dystrophy, Landouzy-Dejerine
has_obo_namespace: disease_ontology
id: DOID:11727
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Lyme disease
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.
imported from: doid.owl
has_alternative_id: DOID:12233
has cross-reference: GARD:12073
has cross-reference: ICD10CM:A69.2
has cross-reference: ICD9CM:088.81
has cross-reference: MESH:D008193
has cross-reference: MESH:D020852
has cross-reference: NCI:C45161
has cross-reference: SNOMEDCT_US_2020_03_01:154376000
has cross-reference: SNOMEDCT_US_2020_03_01:715507005
has cross-reference: UMLS_CUI:C0024198
has cross-reference: UMLS_CUI:C0752235
alternative_term: Bannwarth syndrome
alternative_term: Bannworth's syndrome
alternative_term: Lyme borreliosis
alternative_term: Neurological Lyme disease
alternative_term: lyme neuroboInOwlrreliosis
alternative_term: neuroboInOwlrreliosis
has_obo_namespace: disease_ontology
id: DOID:11729
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

choledocholithiasis
type: Class
subclass of: common bile duct disease
imported from: doid.owl
has cross-reference: MESH:D042883
has cross-reference: SNOMEDCT_US_2020_03_01:197397004
has cross-reference: UMLS_CUI:C0701818
has_obo_namespace: disease_ontology
id: DOID:11755

hypochromic anemia
type: Class
subclass of: anemia
imported from: doid.owl
has cross-reference: ICD10CM:D50
has cross-reference: MESH:D000747
has cross-reference: NCI:C34380
has cross-reference: SNOMEDCT_US_2020_03_01:44452003
has cross-reference: UMLS_CUI:C0002884
alternative_term: ANEMIA HYPOCHROMIC
has_obo_namespace: disease_ontology
id: DOID:11759
in subset: NCIthesaurus

bronchial disease
type: Class
subclass of: lower respiratory tract disease
textual definition: A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage.
imported from: doid.owl
has_alternative_id: DOID:1175
has_alternative_id: DOID:12322
has cross-reference: MESH:D001982
has cross-reference: SNOMEDCT_US_2020_03_01:41427001
has cross-reference: UMLS_CUI:C0006261
alternative_term: Bronchospasm
has_obo_namespace: disease_ontology
id: DOID:1176

spontaneous ocular nystagmus
type: Class
subclass of: DOID 9650
imported from: doid.owl
has cross-reference: ICD10CM:H55.03
has cross-reference: ICD9CM:379.53
has cross-reference: MESH:D009759
has cross-reference: SNOMEDCT_US_2020_03_01:39771000
has cross-reference: UMLS_CUI:C0271384
alternative_term: Ocular nystagmus
alternative_term: Searching eye movements
alternative_term: visual deprivation nystagmus
has_obo_namespace: disease_ontology
id: DOID:11771

leukocoria
type: Class
subclass of: DOID 9799
imported from: doid.owl
has cross-reference: ICD10CM:H44.53
has cross-reference: ICD9CM:360.44
has cross-reference: SNOMEDCT_US_2020_03_01:193288000
has cross-reference: UMLS_CUI:C0152458
alternative_term: Leucocoria
has_obo_namespace: disease_ontology
id: DOID:11772

regular astigmatism
type: Class
subclass of: astigmatism
imported from: doid.owl
has cross-reference: ICD10CM:H52.22
has cross-reference: ICD9CM:367.21
has cross-reference: SNOMEDCT_US_2020_03_01:68905002
has cross-reference: UMLS_CUI:C0152193
has_obo_namespace: disease_ontology
id: DOID:11781

astigmatism
type: Class
subclass of: DOID 9835
textual definition: A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision.
imported from: doid.owl
has cross-reference: EFO:0004222
has cross-reference: ICD10CM:H52.2
has cross-reference: ICD9CM:367.2
has cross-reference: MESH:D001251
has cross-reference: OMIM:603047
has cross-reference: SNOMEDCT_US_2020_03_01:155134009
has cross-reference: UMLS_CUI:C0004106
has_obo_namespace: disease_ontology
id: DOID:11782
comment: OMIM mapping confirmed by DO. [SN].

splenic sequestration
type: Class
subclass of: splenic disease
imported from: doid.owl
has cross-reference: ICD9CM:289.52
has cross-reference: UMLS_CUI:C1260402
has_obo_namespace: disease_ontology
id: DOID:11786

pericardial effusion
type: Class
subclass of: pericardium disease
textual definition: A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.
imported from: doid.owl
has cross-reference: MESH:D010490
has cross-reference: NCI:C3319
has cross-reference: SNOMEDCT_US_2020_03_01:70370001
has cross-reference: UMLS_CUI:C0031039
has_obo_namespace: disease_ontology
id: DOID:118
in subset: NCIthesaurus

protein-energy malnutrition
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by inadequate dietary protein and calories, which can have profound systemic effects including decreased metabolism, altered tissue distribution, compromised immunity, and impaired growth, and has_material_basis_in dietary deprivation.
imported from: doid.owl
has cross-reference: ICD10CM:E46
has cross-reference: ICD9CM:263.9
has cross-reference: MESH:D011502
has cross-reference: NCI:C34952
has cross-reference: SNOMEDCT_US_2020_03_01:72608005
has cross-reference: UMLS_CUI:C0033677
has_obo_namespace: disease_ontology
id: DOID:11801
in subset: NCIthesaurus

vitreous syneresis
type: Class
subclass of: DOID 9720
imported from: doid.owl
has cross-reference: ICD10CM:H43.81
has cross-reference: ICD9CM:379.21
has cross-reference: SNOMEDCT_US_2020_03_01:60189009
has cross-reference: UMLS_CUI:C0155366
alternative_term: Vitreous degeneration
has_obo_namespace: disease_ontology
id: DOID:11816

ureter cancer
type: Class
subclass of: ureteral disease
subclass of: urinary system cancer
textual definition: A urinary system cancer that is located_in the ureter.
imported from: doid.owl
has cross-reference: ICD10CM:C66
has cross-reference: ICD9CM:189.2
has cross-reference: MESH:D014516
has cross-reference: NCI:C7543
has cross-reference: OMIM:191600
has cross-reference: SNOMEDCT_US_2020_03_01:94121005
has cross-reference: UMLS_CUI:C0153619
alternative_term: malignant tumour of ureter
alternative_term: malignant ureteral tumor
has_obo_namespace: disease_ontology
id: DOID:11819
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: OMIM mapping confirmed by DO. [SN].

multicentric reticulohistiocytosis
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.
imported from: doid.owl
has cross-reference: GARD:7103
has cross-reference: ICD10CM:E78.81
has cross-reference: NCI:C27896
has cross-reference: ORDO:139436
has cross-reference: SNOMEDCT_US_2020_03_01:84241008
has cross-reference: UMLS_CUI:C0311284
alternative_term: Lipoid dermatoarthritis
alternative_term: Multicentric reticulohistiocytosis
has_obo_namespace: disease_ontology
id: DOID:11824
in subset: DO rare slim
in subset: NCIthesaurus

myopia
type: Class
subclass of: DOID 9835
textual definition: A refractive error characterized by the inability to see farther objects clearly.
imported from: doid.owl
has cross-reference: EFO:0003927
has cross-reference: ICD10CM:H52.1
has cross-reference: ICD9CM:367.1
has cross-reference: MESH:D009216
has cross-reference: NCI:C102533
has cross-reference: OMIM:160700
has cross-reference: OMIM:255500
has cross-reference: OMIM:300613
has cross-reference: OMIM:310460
has cross-reference: OMIM:603221
has cross-reference: OMIM:608367
has cross-reference: OMIM:608474
has cross-reference: OMIM:608908
has cross-reference: OMIM:609256
has cross-reference: OMIM:609257
has cross-reference: OMIM:609258
has cross-reference: OMIM:609259
has cross-reference: OMIM:609994
has cross-reference: OMIM:609995
has cross-reference: OMIM:610320
has cross-reference: OMIM:612554
has cross-reference: OMIM:612717
has cross-reference: OMIM:613959
has cross-reference: OMIM:613969
has cross-reference: OMIM:614166
has cross-reference: OMIM:614167
has cross-reference: OMIM:615420
has cross-reference: OMIM:615431
has cross-reference: OMIM:615946
has cross-reference: SNOMEDCT_US_2020_03_01:155133003
has cross-reference: UMLS_CUI:C0027092
alternative_term: near vision
alternative_term: near-sightedness
alternative_term: short-sightedness
has_obo_namespace: disease_ontology
id: DOID:11830
in subset: NCIthesaurus
comment: Xref MGI.

cortical blindness
type: Class
subclass of: visual cortex disease
imported from: doid.owl
has cross-reference: ICD10CM:H47.61
has cross-reference: ICD9CM:377.75
has cross-reference: MESH:D019575
has cross-reference: NCI:C118707
has cross-reference: SNOMEDCT_US_2020_03_01:68574006
has cross-reference: UMLS_CUI:C0155320
has_obo_namespace: disease_ontology
id: DOID:11831
in subset: NCIthesaurus

visual epilepsy
type: Class
subclass of: epilepsy
imported from: doid.owl
has cross-reference: MESH:D012640
has cross-reference: NCI:C3980
has cross-reference: SNOMEDCT_US_2020_03_01:39194005
has cross-reference: UMLS_CUI:C0270824
alternative_term: epilepsy, visual
has_obo_namespace: disease_ontology
id: DOID:11832
in subset: NCIthesaurus

clubfoot
type: Class
subclass of: bone development disease
textual definition: A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.
imported from: doid.owl
has_alternative_id: DOID:0001874
has cross-reference: ICD10CM:Q66.89
has cross-reference: ICD9CM:754.51
has cross-reference: MESH:D003025
has cross-reference: NCI:C84641
has cross-reference: OMIM:119800
has cross-reference: SNOMEDCT_US_2020_03_01:33163000
has cross-reference: UMLS_CUI:C0009081
alternative_term: Congenital equinovarus
alternative_term: Equinovarus deformity of foot
alternative_term: congenital clubfoot
alternative_term: congenital talipes equinovarus
has_obo_namespace: disease_ontology
id: DOID:11836
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

nephrotic syndrome
type: Class
subclass of: nephrosis
textual definition: A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.
imported from: doid.owl
has cross-reference: ICD10CM:N04
has cross-reference: ICD9CM:581
has cross-reference: MESH:D009404
has cross-reference: NCI:C34845
has cross-reference: SNOMEDCT_US_2020_03_01:155851004
has cross-reference: UMLS_CUI:C0027726
has_obo_namespace: disease_ontology
id: DOID:1184
in subset: NCIthesaurus
comment: Xref MGI.

coronary artery vasospasm
type: Class
subclass of: coronary artery disease
imported from: doid.owl
has cross-reference: MESH:D003329
has cross-reference: NCI:C34515
has cross-reference: SNOMEDCT_US_2020_03_01:23687008
has cross-reference: UMLS_CUI:C0010073
alternative_term: Coronary Vasospasm
alternative_term: Coronary artery spasm
has_obo_namespace: disease_ontology
id: DOID:11840
in subset: NCIthesaurus

tibial neuropathy
type: Class
subclass of: mononeuropathy
imported from: doid.owl
has cross-reference: MESH:D020429
has cross-reference: SNOMEDCT_US_2020_03_01:359842002
has cross-reference: UMLS_CUI:C0751932
alternative_term: Posterior tibial neuropathy
alternative_term: Tibial neuropathy
has_obo_namespace: disease_ontology
id: DOID:1187

Pick's disease
type: Class
subclass of: neurodegenerative disease
imported from: doid.owl
has cross-reference: GARD:7392
has cross-reference: ICD10CM:G31.01
has cross-reference: ICD9CM:331.11
has cross-reference: MESH:D020774
has cross-reference: NCI:C85008
has cross-reference: OMIM:172700
has cross-reference: SNOMEDCT_US_2020_03_01:154998003
has cross-reference: UMLS_CUI:C0236642
alternative_term: Dementia in Pick's disease
alternative_term: LOBAR ATROPHY OF BRAIN
alternative_term: PICK DISEASE OF BRAIN
alternative_term: Pick disease
has_obo_namespace: disease_ontology
id: DOID:11870
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

denture stomatitis
type: Class
subclass of: DOID 9637
imported from: doid.owl
has cross-reference: ICD10CM:K12.1
has cross-reference: MESH:D013282
has cross-reference: SNOMEDCT_US_2020_03_01:196576008
has cross-reference: UMLS_CUI:C0038364
alternative_term: Denture sore mouth
has_obo_namespace: disease_ontology
id: DOID:11875

mononeuropathy
type: Class
subclass of: DOID 870
textual definition: A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.
imported from: doid.owl
has cross-reference: ICD10CM:G58.9
has cross-reference: MESH:D020422
has cross-reference: SNOMEDCT_US_2020_03_01:304595001
has cross-reference: UMLS_CUI:C0494491
has_obo_namespace: disease_ontology
id: DOID:1188

ureteral benign neoplasm
type: Class
subclass of: ureteral disease
subclass of: urinary system benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D014516
has cross-reference: NCI:C3427
has cross-reference: SNOMEDCT_US_2020_03_01:126882009
has cross-reference: UMLS_CUI:C0041955
alternative_term: neoplasm of ureter
alternative_term: ureteral tumor
has_obo_namespace: disease_ontology
id: DOID:11885
in subset: NCIthesaurus

vaginal cancer
type: Class
subclass of: female reproductive organ cancer
subclass of: vaginal disease
textual definition: A female reproductive system cancer that is located_in the vagina.
imported from: doid.owl
has_alternative_id: DOID:1902
has cross-reference: GARD:9348
has cross-reference: ICD10CM:C52
has cross-reference: ICD9CM:184.0
has cross-reference: MESH:D014625
has cross-reference: NCI:C3437
has cross-reference: NCI:C7410
has cross-reference: SNOMEDCT_US_2020_03_01:126921000
has cross-reference: SNOMEDCT_US_2020_03_01:188210000
has cross-reference: UMLS_CUI:C0042237
has cross-reference: UMLS_CUI:C0042258
alternative_term: malignant neoplasm of vagina
alternative_term: malignant tumor of vagina
alternative_term: malignant vaginal tumor
alternative_term: neoplasm of vagina
alternative_term: vagina neoplasm
alternative_term: vaginal tumor
has_obo_namespace: disease_ontology
id: DOID:119
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

gastroparesis
type: Class
subclass of: functional gastric disease
imported from: doid.owl
has cross-reference: ICD10CM:K31.84
has cross-reference: ICD9CM:536.3
has cross-reference: MESH:D018589
has cross-reference: NCI:C80512
has cross-reference: SNOMEDCT_US_2020_03_01:235675006
has cross-reference: UMLS_CUI:C0152020
alternative_term: Gastroparalysis
alternative_term: Gastroparesis syndrome
alternative_term: gastric atonia
has_obo_namespace: disease_ontology
id: DOID:11914
in subset: NCIthesaurus

tinea cruris
type: Class
subclass of: skin disease
subclass of: DOID 8913
textual definition: A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.
imported from: doid.owl
has cross-reference: ICD9CM:110.3
has cross-reference: NCI:C34535
has cross-reference: SNOMEDCT_US_2020_03_01:59089002
has cross-reference: UMLS_CUI:C0011638
alternative_term: Dermatophytosis of Groin and Perianal Area
alternative_term: Dermatophytosis of groin & perianal area
alternative_term: Dermatophytosis of groin and perianal area
alternative_term: Dhobie itch
has_obo_namespace: disease_ontology
id: DOID:11917
in subset: NCIthesaurus

peripheral nervous system neoplasm
type: Class
subclass of: nervous system cancer
subclass of: peripheral nervous system disease
textual definition: A nervous system cancer that is located in the peripheral nervous system.
imported from: doid.owl
has_alternative_id: DOID:3194
has cross-reference: MESH:D010524
has cross-reference: MESH:D018317
has cross-reference: NCI:C3321
has cross-reference: NCI:C4972
has cross-reference: SNOMEDCT_US_2020_03_01:126980002
has cross-reference: SNOMEDCT_US_2020_03_01:189946005
has cross-reference: UMLS_CUI:C0031118
has cross-reference: UMLS_CUI:C0206727
alternative_term: neoplasm of peripheral nerve
alternative_term: nerve sheath neoplasm
alternative_term: tumor of PNS
has_obo_namespace: disease_ontology
id: DOID:1192
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

tracheal cancer
type: Class
subclass of: respiratory system cancer
subclass of: tracheal disease
textual definition: A respiratory system cancer that is located_in the trachea.
imported from: doid.owl
has cross-reference: ICD10CM:C33
has cross-reference: ICD9CM:162.0
has cross-reference: NCI:C9346
has cross-reference: SNOMEDCT_US_2020_03_01:187855003
has cross-reference: UMLS_CUI:C0153489
has_obo_namespace: disease_ontology
id: DOID:11920
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

head and neck cancer
type: Class
subclass of: organ system cancer
subclass of: cancer
textual definition: An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx.
imported from: doid.owl
has cross-reference: GARD:12425
has cross-reference: MESH:D006258
has cross-reference: NCI:C3077
has cross-reference: SNOMEDCT_US_2020_03_01:255055008
has cross-reference: UMLS_CUI:C0018671
alternative_term: head and neck neoplasm
alternative_term: head and neck tumours
alternative_term: head/neck neoplasm
alternative_term: tumor of head and neck
has_obo_namespace: disease_ontology
id: DOID:11934
in subset: DO MGI slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

Creutzfeldt-Jakob disease
type: Class
subclass of: prion disease
imported from: doid.owl
has cross-reference: EFO:0004226
has cross-reference: GARD:6956
has cross-reference: ICD10CM:A81.0
has cross-reference: ICD9CM:046.1
has cross-reference: MESH:D007562
has cross-reference: NCI:C26802
has cross-reference: OMIM:123400
has cross-reference: SNOMEDCT_US_2020_03_01:155061007
has cross-reference: UMLS_CUI:C0022336
alternative_term: CJD
alternative_term: Creutzfeldt Jacob syndrome
alternative_term: Creutzfeldt Jakob disease
alternative_term: Creutzfeldt-Jacob disease
alternative_term: Jakob-Creutzfeldt disease
alternative_term: Subacute spongiform encephalopathy
alternative_term: Transmissible virus dementia
has_obo_namespace: disease_ontology
id: DOID:11949
in subset: NCIthesaurus
in subset: zoonotic infectious disease
comment: OMIM mapping confirmed by DO. [SN].

ischemic neuropathy
type: Class
subclass of: DOID 870
imported from: doid.owl
has cross-reference: NCI:C27025
has cross-reference: SNOMEDCT_US_2020_03_01:129611009
has cross-reference: UMLS_CUI:C0238309
alternative_term: Ischemic peripheral neuropathy
has_obo_namespace: disease_ontology
id: DOID:1195
in subset: NCIthesaurus

esophagitis
type: Class
subclass of: esophageal disease
imported from: doid.owl
has_alternative_id: DOID:11962
has cross-reference: ICD10CM:K20
has cross-reference: ICD9CM:530.1
has cross-reference: MESH:D004941
has cross-reference: NCI:C9224
has cross-reference: SNOMEDCT_US_2020_03_01:155673008
has cross-reference: UMLS_CUI:C0014868
alternative_term: acute esophagitis
has_obo_namespace: disease_ontology
id: DOID:11963
in subset: NCIthesaurus

synostosis
type: Class
subclass of: dysostosis
textual definition: A dysostosis that results_in abnormal fusing of adjacent bones.
imported from: doid.owl
has cross-reference: MESH:D013580
has cross-reference: UMLS_CUI:C0039093
has_obo_namespace: disease_ontology
id: DOID:11971

botulism
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F.
imported from: doid.owl
has cross-reference: GARD:943
has cross-reference: ICD10CM:A05.1
has cross-reference: MESH:D001906
has cross-reference: NCI:C84599
has cross-reference: SNOMEDCT_US_2020_03_01:154276003
has cross-reference: UMLS_CUI:C0006057
alternative_term: Botulism poisoning
alternative_term: Food poisoning due to Clostridium botulinum
alternative_term: Foodborne botulism
alternative_term: Infection due to clostridium botulinum
alternative_term: Intoxication with Clostridium botulinum toxin
has_obo_namespace: disease_ontology
id: DOID:11976
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

morbid obesity
type: Class
subclass of: DOID 9970
imported from: doid.owl
has cross-reference: ICD9CM:278.01
has cross-reference: MESH:D009767
has cross-reference: NCI:C34858
has cross-reference: SNOMEDCT_US_2020_03_01:389986000
has cross-reference: UMLS_CUI:C0028756
alternative_term: Severe obesity
has_obo_namespace: disease_ontology
id: DOID:11981
in subset: NCIthesaurus

Prader-Willi syndrome
type: Class
subclass of: chromosomal disease
subclass of: syndrome
textual definition: A chromosomal disease that is characterized by weak muscle tone, feeding difficulties, poor growth, and delayed development. Beginning in childhood, affected individuals develop an insatiable appetite, which leads to chronic overeating and obesity.
imported from: doid.owl
has cross-reference: GARD:5575
has cross-reference: ICD10CM:Q87.11
has cross-reference: ICD9CM:759.81
has cross-reference: MESH:D011218
has cross-reference: NCI:C75463
has cross-reference: OMIM:176270
has cross-reference: ORDO:739
has cross-reference: SNOMEDCT_US_2020_03_01:205794007
has cross-reference: UMLS_CUI:C0032897
alternative_term: Prader Willi syndrome
has_obo_namespace: disease_ontology
id: DOID:11983
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hypertrophic cardiomyopathy
type: Class
subclass of: intrinsic cardiomyopathy
textual definition: An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.
imported from: doid.owl
has_alternative_id: DOID:11986
has cross-reference: ICD9CM:425.1
has cross-reference: KEGG:05410
has cross-reference: MESH:D002312
has cross-reference: MESH:D024741
has cross-reference: NCI:C34449
has cross-reference: NCI:C84773
has cross-reference: ORDO:217568
has cross-reference: SNOMEDCT_US_2020_03_01:389998005
has cross-reference: SNOMEDCT_US_2020_03_01:83978005
has cross-reference: UMLS_CUI:C0007194
has cross-reference: UMLS_CUI:C0949658
alternative_term: familial hypertrophic cardiomyopathy
alternative_term: hypertrophic obstructive cardiomyopathy
has_obo_namespace: disease_ontology
id: DOID:11984
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

osteopoikilosis
type: Class
subclass of: osteosclerosis
textual definition: An osteosclerosis that results_in numerous bone islands located_in skeleton.
imported from: doid.owl
has cross-reference: GARD:4158
has cross-reference: ICD10CM:Q78.8
has cross-reference: ICD9CM:756.53
has cross-reference: MESH:D010023
has cross-reference: NCI:C84985
has cross-reference: SNOMEDCT_US_2020_03_01:9147009
has cross-reference: UMLS_CUI:C0029455
has_obo_namespace: disease_ontology
id: DOID:11991
in subset: NCIthesaurus

atrophy of testis
type: Class
subclass of: testicular disease
imported from: doid.owl
has cross-reference: ICD10CM:N50.0
has cross-reference: ICD9CM:608.3
has cross-reference: NCI:C123259
has cross-reference: SNOMEDCT_US_2020_03_01:155938008
has cross-reference: UMLS_CUI:C0156312
has_obo_namespace: disease_ontology
id: DOID:11994
in subset: NCIthesaurus

spermatic cord torsion
type: Class
subclass of: testicular disease
imported from: doid.owl
has cross-reference: ICD10CM:N44.02
has cross-reference: ICD9CM:608.2
has cross-reference: MESH:D013086
has cross-reference: NCI:C26885
has cross-reference: OMIM:187400
has cross-reference: SNOMEDCT_US_2020_03_01:198046000
has cross-reference: UMLS_CUI:C0037856
alternative_term: Torsion of testicle
alternative_term: Torsion of testis
alternative_term: testicular Torsion
has_obo_namespace: disease_ontology
id: DOID:11996
in subset: NCIthesaurus

spermatocele
type: Class
subclass of: male reproductive system disease
imported from: doid.owl
has cross-reference: ICD10CM:N43.4
has cross-reference: ICD9CM:608.1
has cross-reference: MESH:D013088
has cross-reference: NCI:C120909
has cross-reference: SNOMEDCT_US_2020_03_01:155936007
has cross-reference: UMLS_CUI:C0037859
has_obo_namespace: disease_ontology
id: DOID:11997
in subset: NCIthesaurus

female reproductive organ cancer
type: Class
subclass of: reproductive organ cancer
subclass of: female reproductive system disease
textual definition: A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva.
imported from: doid.owl
has_alternative_id: DOID:1244
has_alternative_id: DOID:1281
has cross-reference: ICD10CM:C57
has cross-reference: ICD9CM:184
has cross-reference: MESH:D005833
has cross-reference: NCI:C3053
has cross-reference: NCI:C4913
has cross-reference: SNOMEDCT_US_2020_03_01:126907002
has cross-reference: SNOMEDCT_US_2020_03_01:188207007
has cross-reference: UMLS_CUI:C0017416
has cross-reference: UMLS_CUI:C0153585
has cross-reference: UMLS_CUI:C0699889
alternative_term: female reproductive cancer
alternative_term: malignant Gynecologic tumor
alternative_term: malignant neoplasm of female genital organ
has_obo_namespace: disease_ontology
id: DOID:120
in subset: NCIthesaurus

anterior ischemic optic neuropathy
type: Class
subclass of: optic nerve disease
imported from: doid.owl
has cross-reference: GARD:9790
has cross-reference: ICD10CM:H47.01
has cross-reference: ICD9CM:377.41
has cross-reference: MESH:D018917
has cross-reference: SNOMEDCT_US_2020_03_01:14357004
has cross-reference: UMLS_CUI:C0155305
alternative_term: Ischemic optic neuropathy
has_obo_namespace: disease_ontology
id: DOID:12010

Conn's syndrome
type: Class
subclass of: adrenal adenoma
textual definition: An adrenal adenoma characterized by the over production of aldosterone.
imported from: doid.owl
has cross-reference: GARD:7456
has cross-reference: ICD10CM:E26.01
has cross-reference: ICD9CM:255.12
has cross-reference: MESH:D006929
has cross-reference: NCI:C34510
has cross-reference: SNOMEDCT_US_2020_03_01:13536004
has cross-reference: UMLS_CUI:C1384514
alternative_term: Conn syndrome
alternative_term: primary aldosteronism
alternative_term: primary hyperaldosteronism
has_obo_namespace: disease_ontology
id: DOID:12028
in subset: NCIthesaurus

drug-induced mental disorder
type: Class
subclass of: DOID 8646
imported from: doid.owl
has cross-reference: ICD9CM:292.8
has cross-reference: UMLS_CUI:C0154325
has_obo_namespace: disease_ontology
id: DOID:1203

panuveitis
type: Class
subclass of: uveitis
textual definition: An uveitis that is characterized by inflammation of all layers of the uvea (middle layer) of the eye, which includes the iris, ciliary body, and choroid.
imported from: doid.owl
has cross-reference: GARD:8577
has cross-reference: ICD10CM:H44.11
has cross-reference: ICD9CM:360.12
has cross-reference: MESH:D015864
has cross-reference: NCI:C84989
has cross-reference: SNOMEDCT_US_2020_03_01:75614007
has cross-reference: UMLS_CUI:C0030343
alternative_term: Diffuse uveitis
has_obo_namespace: disease_ontology
id: DOID:12030
in subset: NCIthesaurus

allergic disease
type: Class
subclass of: immune system disease
textual definition: An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.
imported from: doid.owl
IEDB alternative term: allergic disease
has cross-reference: ICD10CM:T78.40
has cross-reference: MESH:D006967
has cross-reference: NCI:C3114
has cross-reference: SNOMEDCT_US_2020_03_01:257550005
has cross-reference: UMLS_CUI:C0020517
alternative_term: allergic hypersensitivity disease
alternative_term: hypersensitivity
alternative_term: hypersensitivity reaction type I disease
has_obo_namespace: disease_ontology
id: DOID:1205
in subset: NCIthesaurus

cryptococcosis
type: Class
subclass of: opportunistic mycosis
textual definition: An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii.
imported from: doid.owl
has cross-reference: GARD:6218
has cross-reference: ICD10CM:B45
has cross-reference: ICD9CM:117.5
has cross-reference: MESH:D003453
has cross-reference: NCI:C2967
has cross-reference: SNOMEDCT_US_2020_03_01:42386007
has cross-reference: UMLS_CUI:C0010414
alternative_term: Busse-Buschke's disease
alternative_term: European cryptococcosis
alternative_term: cryptococcal infection
alternative_term: torula
alternative_term: torulosis
has_obo_namespace: disease_ontology
has_related_synonym: cryptococcus neoformans infection
id: DOID:12053
in subset: NCIthesaurus

Rett syndrome
type: Class
subclass of: pervasive developmental disorder
textual definition: A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability.
imported from: doid.owl
has cross-reference: GARD:5696
has cross-reference: ICD10CM:F84.2
has cross-reference: MESH:D015518
has cross-reference: NCI:C75488
has cross-reference: OMIM:312750
has cross-reference: OMIM:613454
has cross-reference: SNOMEDCT_US_2020_03_01:192583003
has cross-reference: UMLS_CUI:C0035372
alternative_term: Rett's disorder
alternative_term: cerebroatrophic hyperammonemia
has_obo_namespace: disease_ontology
id: DOID:1206
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

trigeminal neuralgia
type: Class
subclass of: trigeminal nerve disease
imported from: doid.owl
has cross-reference: GARD:7805
has cross-reference: ICD10CM:G50.0
has cross-reference: ICD9CM:350.1
has cross-reference: MESH:D014277
has cross-reference: OMIM:190400
has cross-reference: SNOMEDCT_US_2020_03_01:155066002
has cross-reference: UMLS_CUI:C0040997
alternative_term: Trifacial neuralgia
alternative_term: Trigeminal neuralgia
alternative_term: trifocal neuralgia
has_obo_namespace: disease_ontology
id: DOID:12098
comment: OMIM mapping confirmed by DO. [LS].

vaginal disease
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is located_in the vagina.
imported from: doid.owl
has cross-reference: MESH:D014623
has cross-reference: NCI:C26910
has cross-reference: SNOMEDCT_US_2020_03_01:25658005
has cross-reference: UMLS_CUI:C0042251
has_obo_namespace: disease_ontology
id: DOID:121
in subset: NCIthesaurus

optic neuritis
type: Class
subclass of: optic nerve disease
textual definition: An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision.
imported from: doid.owl
has cross-reference: GARD:7320
has cross-reference: ICD10CM:H46
has cross-reference: ICD9CM:377.3
has cross-reference: MESH:D009902
has cross-reference: NCI:C84950
has cross-reference: SNOMEDCT_US_2020_03_01:194051001
has cross-reference: UMLS_CUI:C0029134
has_obo_namespace: disease_ontology
id: DOID:1210
in subset: NCIthesaurus

pulmonary alveolar microlithiasis
type: Class
subclass of: lung disease
textual definition: A lung disease that is characterized the accumulation of tiny fragments of calcium phosphate gradually accumulate in the alveoli of the lungs.
imported from: doid.owl
has cross-reference: GARD:11894
has cross-reference: ICD10CM:J84.02
has cross-reference: ICD9CM:516.2
has cross-reference: MESH:C562405
has cross-reference: OMIM:265100
has cross-reference: SNOMEDCT_US_2020_03_01:196160008
has cross-reference: UMLS_CUI:C0155912
has_obo_namespace: disease_ontology
id: DOID:12117
comment: OMIM mapping confirmed by DO. [SN].

hemosiderosis
type: Class
subclass of: iron metabolism disease
textual definition: An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.
imported from: doid.owl
has cross-reference: GARD:6595
has cross-reference: MESH:D006486
has cross-reference: NCI:C82892
has cross-reference: SNOMEDCT_US_2020_03_01:39011001
has cross-reference: UMLS_CUI:C0019114
alternative_term: haemosiderosis
has_obo_namespace: disease_ontology
id: DOID:12119
in subset: NCIthesaurus

pulmonary alveolar proteinosis
type: Class
subclass of: lung disease
textual definition: A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange.
imported from: doid.owl
has cross-reference: ICD10CM:J84.01
has cross-reference: ICD9CM:516.0
has cross-reference: MESH:D011649
has cross-reference: NCI:C85037
has cross-reference: OMIM:265120
has cross-reference: OMIM:300770
has cross-reference: OMIM:610913
has cross-reference: OMIM:610921
has cross-reference: OMIM:614370
has cross-reference: ORDO:264675
has cross-reference: SNOMEDCT_US_2020_03_01:10501004
has cross-reference: UMLS_CUI:C0034050
has_obo_namespace: disease_ontology
id: DOID:12120
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

granulomatosis with polyangiitis
type: Class
subclass of: autoimmune disease of blood
subclass of: skin disease
subclass of: kidney disease
subclass of: lung disease
textual definition: An autoimmune disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera, and is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.
imported from: doid.owl
has cross-reference: GARD:7880
has cross-reference: ICD10CM:M31.3
has cross-reference: ICD9CM:446.4
has cross-reference: MESH:D014890
has cross-reference: NCI:C3444
has cross-reference: OMIM:608710
has cross-reference: SNOMEDCT_US_2020_03_01:195353004
has cross-reference: UMLS_CUI:C3495801
alternative_term: Necrotizing respiratory granulomatosis
alternative_term: Wegener granulomatosis, formerly
has_obo_namespace: disease_ontology
id: DOID:12132
in subset: NCIthesaurus

factor VIII deficiency
type: Class
subclass of: X-linked recessive disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged.
imported from: doid.owl
has cross-reference: GARD:6591
has cross-reference: ICD10CM:D66
has cross-reference: ICD9CM:286.0
has cross-reference: MESH:D006467
has cross-reference: NCI:C27146
has cross-reference: OMIM:306700
has cross-reference: ORDO:98878
has cross-reference: SNOMEDCT_US_2020_03_01:28293008
has cross-reference: UMLS_CUI:C0019069
alternative_term: Congenital factor VIII disorder
alternative_term: Hemophilia A
alternative_term: Subhemophilia
alternative_term: classic hemophilia A
has_obo_namespace: disease_ontology
id: DOID:12134
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

dysthymic disorder
type: Class
subclass of: mood disorder
textual definition: A mood disorder that involves the presence of a low mood almost daily over a span of at least two years.
imported from: doid.owl
has cross-reference: ICD10CM:F34.1
has cross-reference: ICD9CM:300.4
has cross-reference: MESH:D019263
has cross-reference: NCI:C34562
has cross-reference: SNOMEDCT_US_2020_03_01:192384008
has cross-reference: UMLS_CUI:C0013415
alternative_term: dysthymia
has_obo_namespace: disease_ontology
id: DOID:12139
in subset: NCIthesaurus

Chagas disease
type: Class
subclass of: trypanosomiasis
textual definition: A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.
imported from: doid.owl
has_alternative_id: DOID:0050016
has_alternative_id: DOID:0050019
has_alternative_id: DOID:0050020
has cross-reference: GARD:6030
has cross-reference: ICD9CM:086.2
has cross-reference: KEGG:05142
has cross-reference: SNOMEDCT_US_2020_03_01:186817003
has cross-reference: UMLS_CUI:C0007932
alternative_term: Chagas' disease
alternative_term: chagas' disease with digestive system involvement
alternative_term: chagas' disease with nervous system involvement
alternative_term: chagas' disease with other organ involvement
has_obo_namespace: disease_ontology
has_related_synonym: American trypanosomiasis
id: DOID:12140
in subset: zoonotic infectious disease

neurogenic bladder
type: Class
subclass of: bladder disease
imported from: doid.owl
has cross-reference: ICD9CM:596.54
has cross-reference: MESH:D001750
has cross-reference: NCI:C79696
has cross-reference: SNOMEDCT_US_2020_03_01:192972000
has cross-reference: UMLS_CUI:C0005697
alternative_term: Neuropathic bladder
alternative_term: neurogenic dysfunction of the urinary bladder
alternative_term: neurogenic urinary bladder disorder
has_obo_namespace: disease_ontology
id: DOID:12143
in subset: NCIthesaurus

low compliance bladder
type: Class
subclass of: bladder disease
imported from: doid.owl
has cross-reference: ICD9CM:596.52
has cross-reference: SNOMEDCT_US_2020_03_01:9009001
has cross-reference: UMLS_CUI:C0489967
alternative_term: Low bladder compliance
alternative_term: hyperactivity of bladder
alternative_term: hypertonic bladder
alternative_term: hypertonicity of bladder
has_obo_namespace: disease_ontology
id: DOID:12144

detrusor sphincter dyssynergia
type: Class
subclass of: bladder disease
imported from: doid.owl
has cross-reference: ICD9CM:596.55
has cross-reference: SNOMEDCT_US_2020_03_01:236655005
has cross-reference: UMLS_CUI:C0341747
has_obo_namespace: disease_ontology
id: DOID:12145

lymphocytic choriomeningitis
type: Class
subclass of: DOID 934
subclass of: DOID 936
textual definition: A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.
imported from: doid.owl
has_alternative_id: DOID:10662
has cross-reference: ICD10CM:A87.2
has cross-reference: MESH:D008216
has cross-reference: SNOMEDCT_US_2020_03_01:192668002
has cross-reference: UMLS_CUI:C0024266
alternative_term: LCM
alternative_term: Lymphocytic choriomeningitis virus encephalomyelitis
alternative_term: Lymphocytic meningitis
alternative_term: Lymphocytic meningoencephalitis
has_obo_namespace: disease_ontology
id: DOID:12155
in subset: zoonotic infectious disease

peripheral retinal degeneration
type: Class
subclass of: retinal degeneration
imported from: doid.owl
has cross-reference: ICD10CM:H35.4
has cross-reference: ICD9CM:362.6
has cross-reference: NCI:C34919
has cross-reference: SNOMEDCT_US_2020_03_01:193393004
has cross-reference: UMLS_CUI:C1320640
alternative_term: peripheral degeneration of retina
has_obo_namespace: disease_ontology
id: DOID:12161
in subset: NCIthesaurus

ulnar nerve lesion
type: Class
subclass of: mononeuritis of upper limb and mononeuritis multiplex
imported from: doid.owl
has cross-reference: ICD10CM:G56.2
has cross-reference: ICD9CM:354.2
has cross-reference: SNOMEDCT_US_2020_03_01:55802003
has cross-reference: UMLS_CUI:C1288279
alternative_term: Lesion of ulnar nerve
has_obo_namespace: disease_ontology
id: DOID:12168

carpal tunnel syndrome
type: Class
subclass of: nerve compression syndrome
imported from: doid.owl
has cross-reference: ICD10CM:G56.0
has cross-reference: ICD9CM:354.0
has cross-reference: MESH:D002349
has cross-reference: NCI:C34450
has cross-reference: OMIM:115430
has cross-reference: SNOMEDCT_US_2020_03_01:193126005
has cross-reference: UMLS_CUI:C0007286
alternative_term: CTS - Carpal tunnel syndrome
alternative_term: Carpal tunnel syndrome
alternative_term: Median nerve entrapment
alternative_term: carpal tunnel median neuropathy
has_obo_namespace: disease_ontology
id: DOID:12169
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

dyshormonogenic goiter
type: Class
subclass of: goiter
imported from: doid.owl
has cross-reference: ICD10CM:E07.1
has cross-reference: ICD9CM:246.1
has cross-reference: SNOMEDCT_US_2020_03_01:190304001
has cross-reference: UMLS_CUI:C0152077
alternative_term: Dyshormonogenic goiter
alternative_term: Dyshormonogenic goitre
alternative_term: dyshormonogenic goitre
has_obo_namespace: disease_ontology
id: DOID:12175

goiter
type: Class
subclass of: thyroid gland disease
textual definition: A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.
imported from: doid.owl
has cross-reference: ICD10CM:E04.9
has cross-reference: ICD9CM:240.9
has cross-reference: MESH:D006042
has cross-reference: NCI:C26785
has cross-reference: SNOMEDCT_US_2020_03_01:237568003
has cross-reference: UMLS_CUI:C0018021
alternative_term: goitre
has_obo_namespace: disease_ontology
id: DOID:12176
in subset: NCIthesaurus

common variable immunodeficiency
type: Class
subclass of: agammaglobulinemia
subclass of: autoimmune disease
textual definition: An agammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells.
imported from: doid.owl
has cross-reference: GARD:6140
has cross-reference: ICD10CM:D83
has cross-reference: ICD9CM:279.06
has cross-reference: MESH:D017074
has cross-reference: OMIM:240500
has cross-reference: OMIM:607594
has cross-reference: OMIM:613493
has cross-reference: OMIM:613494
has cross-reference: OMIM:613495
has cross-reference: OMIM:613496
has cross-reference: OMIM:614699
has cross-reference: OMIM:614700
has cross-reference: OMIM:615577
has cross-reference: OMIM:615767
has cross-reference: ORDO:1572
has cross-reference: SNOMEDCT_US_2020_03_01:191010004
has cross-reference: UMLS_CUI:C0009447
alternative_term: CVID
alternative_term: acquired agammaglobulinemia
alternative_term: acquired hypogammaglobulinemia
alternative_term: common variable agammaglobulinemia
alternative_term: sporadic hypogammaglobulinemia
has_obo_namespace: disease_ontology
id: DOID:12177
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

otosclerosis
type: Class
subclass of: inner ear disease
textual definition: An otitis interna characterized by an abnormal bone growth in the middle ear.
imported from: doid.owl
has cross-reference: EFO:0004213
has cross-reference: ICD10CM:H80.80
has cross-reference: ICD9CM:387.8
has cross-reference: OMIM:166800
has cross-reference: OMIM:605727
has cross-reference: OMIM:608244
has cross-reference: OMIM:608484
has cross-reference: OMIM:611571
has cross-reference: OMIM:611572
has cross-reference: OMIM:612096
has cross-reference: OMIM:615589
has cross-reference: ORDO:2794
has cross-reference: SNOMEDCT_US_2020_03_01:194382008
has cross-reference: UMLS_CUI:C0029696
has_obo_namespace: disease_ontology
id: DOID:12185
in subset: DO rare slim
comment: Xref MGI.

sigmoid colon cancer
type: Class
subclass of: colon cancer
imported from: doid.owl
has cross-reference: ICD10CM:C18.7
has cross-reference: ICD9CM:153.3
has cross-reference: MESH:D012811
has cross-reference: SNOMEDCT_US_2020_03_01:94006002
has cross-reference: UMLS_CUI:C0153436
alternative_term: Ca sigmoid colon
alternative_term: malignant tumor of sigmoid colon
has_obo_namespace: disease_ontology
id: DOID:12192

punctate epithelial keratoconjunctivitis
type: Class
subclass of: DOID 9368
imported from: doid.owl
has cross-reference: ICD10CM:H16.14
has cross-reference: ICD9CM:370.21
has cross-reference: SNOMEDCT_US_2020_03_01:193767008
has cross-reference: UMLS_CUI:C0259799
alternative_term: Punctate keratitis
alternative_term: Thygeson superficial punctate keratitis
alternative_term: Thygeson's superficial punctate keratitis
has_obo_namespace: disease_ontology
id: DOID:12197

dengue disease
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.
imported from: doid.owl
has_alternative_id: DOID:0050142
has cross-reference: GARD:6254
has cross-reference: ICD10CM:A90
has cross-reference: ICD9CM:061
has cross-reference: MESH:D003715
has cross-reference: NCI:C34528
has cross-reference: SNOMEDCT_US_2020_03_01:38362002
has cross-reference: UMLS_CUI:C0011311
alternative_term: Dengue Fever
alternative_term: breakbone fever
alternative_term: classic dengue
has_obo_namespace: disease_ontology
has_related_synonym: classical dengue
id: DOID:12205
in subset: NCIthesaurus
in subset: zoonotic infectious disease

oligohydramnios
type: Class
subclass of: placenta disease
textual definition: A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.
imported from: doid.owl
has_alternative_id: DOID:12595
has_alternative_id: DOID:12596
has cross-reference: ICD10CM:O41.0
has cross-reference: ICD9CM:658.0
has cross-reference: MESH:D016104
has cross-reference: NCI:C92839
has cross-reference: SNOMEDCT_US_2020_03_01:157051001
has cross-reference: UMLS_CUI:C0079924
alternative_term: Oligohydramnios - delivered
alternative_term: antepartum oligohydramnios
alternative_term: delivered oligohydramnios
has_obo_namespace: disease_ontology
id: DOID:12215
in subset: NCIthesaurus

Lewy body dementia
type: Class
subclass of: dementia
textual definition: A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
imported from: doid.owl
has cross-reference: GARD:3243
has cross-reference: ICD10CM:G31.83
has cross-reference: ICD9CM:331.82
has cross-reference: MESH:D020961
has cross-reference: NCI:C84826
has cross-reference: OMIM:127750
has cross-reference: SNOMEDCT_US_2020_03_01:192808003
has cross-reference: UMLS_CUI:C0752347
alternative_term: Dementia with Lewy bodies
alternative_term: Diffuse Lewy body disease
alternative_term: Lewy body disease
alternative_term: Senile dementia of the Lewy body type
has_obo_namespace: disease_ontology
id: DOID:12217
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cartilage disease
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease that is located_in cartilage.
imported from: doid.owl
has cross-reference: ICD10CM:M94.9
has cross-reference: MESH:D002357
has cross-reference: SNOMEDCT_US_2020_03_01:50927007
has cross-reference: UMLS_CUI:C0007302
alternative_term: Cartilage disorder
alternative_term: Chondropathy
has_obo_namespace: disease_ontology
id: DOID:1222

cascade stomach
type: Class
subclass of: stomach disease
imported from: doid.owl
has cross-reference: ICD10CM:K31.2
has cross-reference: ICD9CM:537.6
has cross-reference: SNOMEDCT_US_2020_03_01:54051005
has cross-reference: UMLS_CUI:C0267183
alternative_term: Hourglass stricture or stenosis of stomach
has_obo_namespace: disease_ontology
id: DOID:12234

primary biliary cholangitis
type: Class
subclass of: autoimmune disease of gastrointestinal tract
subclass of: liver cirrhosis
textual definition: A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.
imported from: doid.owl
has_alternative_id: DOID:1851
has cross-reference: EFO:0004267
has cross-reference: GARD:7459
has cross-reference: ICD10CM:K74.3
has cross-reference: ICD10CM:K74.5
has cross-reference: ICD9CM:571.6
has cross-reference: MESH:D008105
has cross-reference: NCI:C27167
has cross-reference: NCI:C51225
has cross-reference: OMIM:109720
has cross-reference: OMIM:613007
has cross-reference: OMIM:613008
has cross-reference: OMIM:614220
has cross-reference: OMIM:614221
has cross-reference: ORDO:186
has cross-reference: SNOMEDCT_US_2020_03_01:1761006
has cross-reference: SNOMEDCT_US_2020_03_01:31712002
has cross-reference: UMLS_CUI:C0008312
has cross-reference: UMLS_CUI:C0023892
alternative_term: biliary liver cirrhosis
alternative_term: cholestatic cirrhosis
alternative_term: chronic nonsuppurative destructive cholangitis
alternative_term: primary biliary cirrhosis
has_obo_namespace: disease_ontology
id: DOID:12236
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

bile reflux
type: Class
subclass of: DOID 9741
imported from: doid.owl
has cross-reference: MESH:D001655
has cross-reference: UMLS_CUI:C0005403
has_obo_namespace: disease_ontology
id: DOID:12237

testicular lymphoma
type: Class
subclass of: lymphoma
subclass of: testicular cancer
imported from: doid.owl
has cross-reference: NCI:C6810
has cross-reference: SNOMEDCT_US_2020_03_01:277664004
has cross-reference: UMLS_CUI:C0349644
alternative_term: lymphoma of the testis
alternative_term: malignant lymphoma of testis
alternative_term: testicular Lymphoma
has_obo_namespace: disease_ontology
id: DOID:12253
in subset: NCIthesaurus

hemophilia B
type: Class
subclass of: X-linked recessive disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that has_material_basis_in Factor IX deficiency, which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.
imported from: doid.owl
has cross-reference: GARD:8732
has cross-reference: ICD10CM:D67
has cross-reference: ICD9CM:286.1
has cross-reference: MESH:D002836
has cross-reference: NCI:C26721
has cross-reference: OMIM:306900
has cross-reference: SNOMEDCT_US_2020_03_01:41788008
has cross-reference: UMLS_CUI:C0008533
alternative_term: Congenital factor IX deficiency
alternative_term: Congenital factor IX disorder
alternative_term: deficiency, functional factor IX
alternative_term: factor IX deficiency
has_obo_namespace: disease_ontology
id: DOID:12259
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

neutropenia
type: Class
subclass of: agranulocytosis
imported from: doid.owl
has cross-reference: ICD10CM:D70
has cross-reference: ICD9CM:288.0
has cross-reference: MESH:D009503
has cross-reference: SNOMEDCT_US_2020_03_01:191336001
has cross-reference: UMLS_CUI:C0027947
has_obo_namespace: disease_ontology
id: DOID:1227

coloboma
type: Class
subclass of: eye disease
textual definition: An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc.
imported from: doid.owl
has cross-reference: GARD:1433
has cross-reference: ICD10CM:Q13.0
has cross-reference: MESH:D003103
has cross-reference: NCI:C98877
has cross-reference: OMIM:120200
has cross-reference: OMIM:120300
has cross-reference: OMIM:216820
has cross-reference: ORDO:194
has cross-reference: ORDO:98945
has cross-reference: SNOMEDCT_US_2020_03_01:93390002
has cross-reference: UMLS_CUI:C0009363
alternative_term: coloboInOwlma of eye
alternative_term: coloboInOwlma of macula
alternative_term: congenital ocular coloboInOwlma
has_obo_namespace: disease_ontology
id: DOID:12270
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

aniridia
type: Class
subclass of: iris disease
textual definition: An iris disease that is characterized by a complete or partial absence of the colored part of the eye.
imported from: doid.owl
has cross-reference: GARD:5816
has cross-reference: ICD10CM:Q13.1
has cross-reference: ICD9CM:743.45
has cross-reference: MESH:D015783
has cross-reference: NCI:C84563
has cross-reference: OMIM:106210
has cross-reference: SNOMEDCT_US_2020_03_01:69278003
has cross-reference: UMLS_CUI:C0003076
alternative_term: Aplasia of iris
has_obo_namespace: disease_ontology
id: DOID:12271
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

anisometropia
type: Class
subclass of: DOID 9835
imported from: doid.owl
has cross-reference: ICD10CM:H52.31
has cross-reference: ICD9CM:367.31
has cross-reference: MESH:D015858
has cross-reference: SNOMEDCT_US_2020_03_01:3289004
has cross-reference: UMLS_CUI:C0003081
has_obo_namespace: disease_ontology
id: DOID:12273

testicular leukemia
type: Class
subclass of: testicular cancer
imported from: doid.owl
has cross-reference: NCI:C9277
has cross-reference: UMLS_CUI:C1336711
has_obo_namespace: disease_ontology
id: DOID:12286
in subset: NCIthesaurus

Crimean-Congo hemorrhagic fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.
imported from: doid.owl
has cross-reference: ICD10CM:A98.0
has cross-reference: ICD9CM:065.0
has cross-reference: MESH:D006479
has cross-reference: NCI:C34682
has cross-reference: SNOMEDCT_US_2020_03_01:43489008
has cross-reference: UMLS_CUI:C0019099
alternative_term: CHF Congo virus
alternative_term: Congo-Crimean Hemorrhagic Fever
alternative_term: Crimean hemorrhagic fever
has_obo_namespace: disease_ontology
id: DOID:12287
in subset: NCIthesaurus
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

Vogt-Koyanagi-Harada disease
type: Class
subclass of: autoimmune disease of skin and connective tissue
textual definition: An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.
imported from: doid.owl
has cross-reference: GARD:7862
has cross-reference: ICD10CM:H20.82
has cross-reference: ICD9CM:364.24
has cross-reference: MESH:D014607
has cross-reference: NCI:C85218
has cross-reference: SNOMEDCT_US_2020_03_01:44923005
has cross-reference: UMLS_CUI:C0042170
alternative_term: Harada's disease
alternative_term: Vogt-Koyanagi syndrome
alternative_term: uveomeningoencephalitic syndrome
has_obo_namespace: disease_ontology
id: DOID:12297
in subset: NCIthesaurus

vitiligo
type: Class
subclass of: autoimmune disease of skin and connective tissue
textual definition: An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.
imported from: doid.owl
has cross-reference: EFO:0004208
has cross-reference: GARD:10751
has cross-reference: ICD10CM:L80
has cross-reference: ICD9CM:709.01
has cross-reference: MESH:D014820
has cross-reference: NCI:C26915
has cross-reference: OMIM:193200
has cross-reference: SNOMEDCT_US_2020_03_01:156437000
has cross-reference: UMLS_CUI:C0042900
has_obo_namespace: disease_ontology
id: DOID:12306
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

Dubin-Johnson syndrome
type: Class
subclass of: bilirubin metabolic disorder
textual definition: A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin without elevation of liver alanine transaminase and aspartate transaminase enzymes as a result of the deficient ability of hepatocytes to secrete conjugated bilirubin into the bile.
imported from: doid.owl
has cross-reference: GARD:6289
has cross-reference: ICD10CM:E80.6
has cross-reference: MESH:D007566
has cross-reference: NCI:C34741
has cross-reference: OMIM:237500
has cross-reference: SNOMEDCT_US_2020_03_01:44553005
has cross-reference: UMLS_CUI:C0022350
alternative_term: Dubin Johnson syndrome
alternative_term: chronic idiopathic jaundice
has_obo_namespace: disease_ontology
id: DOID:12308
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

granular corneal dystrophy
type: Class
subclass of: autosomal dominant disease
subclass of: epithelial-stromal TGFBI dystrophy
textual definition: An epithelial-stromal TGFBI dystrophy that is characterized by progressive accumulation of deposits within the layers of the cornea.
imported from: doid.owl
has cross-reference: ICD10CM:H18.53
has cross-reference: ICD9CM:371.53
has cross-reference: MESH:D003317
has cross-reference: NCI:C34651
has cross-reference: SNOMEDCT_US_2020_03_01:45283008
has cross-reference: UMLS_CUI:C0018179
alternative_term: granular corneal dystrophy
has_obo_namespace: disease_ontology
id: DOID:12318
in subset: NCIthesaurus

chronic pulmonary heart disease
type: Class
subclass of: Cor pulmonale
imported from: doid.owl
has cross-reference: ICD9CM:416.8
has cross-reference: SNOMEDCT_US_2020_03_01:194887007
has cross-reference: UMLS_CUI:C0155673
has_obo_namespace: disease_ontology
id: DOID:12326

transvestism
type: Class
subclass of: fetishism
imported from: doid.owl
has cross-reference: ICD10CM:F64.1
has cross-reference: ICD9CM:302.3
has cross-reference: MESH:D014190
has cross-reference: NCI:C94359
has cross-reference: SNOMEDCT_US_2020_03_01:472948001
has cross-reference: UMLS_CUI:C0040774
alternative_term: Dual-role transvestism
alternative_term: Fetishistic transvestism
alternative_term: Transvestic fetishism
alternative_term: cross dresser
has_obo_namespace: disease_ontology
id: DOID:1233
in subset: NCIthesaurus

male infertility
type: Class
subclass of: male reproductive system disease
imported from: doid.owl
has cross-reference: ICD10CM:N46
has cross-reference: ICD9CM:606
has cross-reference: MESH:D007248
has cross-reference: SNOMEDCT_US_2020_03_01:155924001
has cross-reference: UMLS_CUI:C0021364
has_obo_namespace: disease_ontology
id: DOID:12336

varicocele
type: Class
subclass of: DOID 9742
imported from: doid.owl
has cross-reference: ICD10CM:I86.1
has cross-reference: ICD9CM:456.4
has cross-reference: MESH:D014646
has cross-reference: SNOMEDCT_US_2020_03_01:195480007
has cross-reference: UMLS_CUI:C0042341
alternative_term: Scrotal varices
has_obo_namespace: disease_ontology
id: DOID:12337

gender identity disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.
imported from: doid.owl
has cross-reference: ICD10CM:F64.2
has cross-reference: ICD9CM:302.6
has cross-reference: SNOMEDCT_US_2020_03_01:5095008
has cross-reference: UMLS_CUI:C0236802
has_obo_namespace: disease_ontology
id: DOID:1234

retroperitoneal sarcoma
type: Class
subclass of: retroperitoneal cancer
textual definition: A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space.
imported from: doid.owl
has cross-reference: NCI:C4832
has cross-reference: SNOMEDCT_US_2020_03_01:307219002
has cross-reference: UMLS_CUI:C0585129
has_obo_namespace: disease_ontology
id: DOID:12341
in subset: NCIthesaurus

osteogenesis imperfecta
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue.
imported from: doid.owl
has_alternative_id: DOID:14708
has cross-reference: GARD:1017
has cross-reference: ICD10CM:Q78.0
has cross-reference: ICD9CM:756.51
has cross-reference: MESH:D010013
has cross-reference: NCI:C26837
has cross-reference: OMIM:PS166200
has cross-reference: ORDO:666
has cross-reference: SNOMEDCT_US_2020_03_01:78314001
has cross-reference: UMLS_CUI:C0029434
alternative_term: Lobstein's syndrome
alternative_term: Osteopsathyrosis
alternative_term: Vrolik's disease
alternative_term: brittle bone disease
has_obo_namespace: disease_ontology
has_related_synonym: Fragilitas ossium
id: DOID:12347
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

fetishism
type: Class
subclass of: paraphilia disorder
imported from: doid.owl
has cross-reference: ICD10CM:F65.0
has cross-reference: ICD9CM:302.81
has cross-reference: MESH:D005329
has cross-reference: NCI:C94353
has cross-reference: SNOMEDCT_US_2020_03_01:192513009
has cross-reference: UMLS_CUI:C0015957
has_obo_namespace: disease_ontology
id: DOID:1235
in subset: NCIthesaurus

alcoholic hepatitis
type: Class
subclass of: hepatitis
imported from: doid.owl
has_alternative_id: DOID:12350
has cross-reference: ICD9CM:571.1
has cross-reference: NCI:C34352
has cross-reference: SNOMEDCT_US_2020_03_01:9953008
has cross-reference: UMLS_CUI:C0001306
alternative_term: Alcoholic Hepatitis
alternative_term: Alcoholic hepatitis
alternative_term: acute Alcoholic Hepatitis
alternative_term: acute alcoholic hepatitis
alternative_term: acute alcoholic liver disease
has_obo_namespace: disease_ontology
id: DOID:12351
in subset: NCIthesaurus

patulous eustachian tube
type: Class
subclass of: DOID 9739
textual definition: A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection.
imported from: doid.owl
has cross-reference: GARD:10812
has cross-reference: ICD10CM:H69.0
has cross-reference: ICD9CM:381.7
has cross-reference: SNOMEDCT_US_2020_03_01:30280005
has cross-reference: UMLS_CUI:C0155434
has_obo_namespace: disease_ontology
id: DOID:12358

Graves' disease
type: Class
subclass of: autoimmune disease of endocrine system
textual definition: An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland.
imported from: doid.owl
has cross-reference: EFO:0004237
has cross-reference: ICD10CM:E05.0
has cross-reference: MESH:D006111
has cross-reference: NCI:C3071
has cross-reference: SNOMEDCT_US_2020_03_01:154655004
has cross-reference: UMLS_CUI:C0018213
alternative_term: Grave's disease
alternative_term: Graves disease
alternative_term: exophthalmic goiter
has_obo_namespace: disease_ontology
has_related_synonym: Basedow's disease
id: DOID:12361
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

malaria
type: Class
subclass of: parasitic protozoa infectious disease
textual definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.
imported from: doid.owl
has_alternative_id: DOID:12552
has cross-reference: EFO:0001068
has cross-reference: GARD:6961
has cross-reference: ICD10CM:B54
has cross-reference: ICD9CM:084
has cross-reference: MESH:D008288
has cross-reference: NCI:C34797
has cross-reference: SNOMEDCT_US_2020_03_01:154374002
has cross-reference: UMLS_CUI:C0024530
alternative_term: induced malaria
has_obo_namespace: disease_ontology
id: DOID:12365
in subset: NCIthesaurus
comment: Xref MGI.

corneal degeneration
type: Class
subclass of: corneal disease
subclass of: DOID 9799
imported from: doid.owl
has cross-reference: ICD10CM:H18.4
has cross-reference: ICD9CM:371.4
has cross-reference: SNOMEDCT_US_2020_03_01:111521006
has cross-reference: UMLS_CUI:C0155118
has_obo_namespace: disease_ontology
id: DOID:1237

bronchopneumonia
type: Class
subclass of: pneumonia
textual definition: A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.
imported from: doid.owl
has cross-reference: ICD10CM:J18.0
has cross-reference: ICD9CM:485
has cross-reference: MESH:D001996
has cross-reference: NCI:C26710
has cross-reference: SNOMEDCT_US_2020_03_01:155551009
has cross-reference: UMLS_CUI:C0006285
alternative_term: Chest infection - bronchopneumonia
alternative_term: bronchial pneumonia
alternative_term: lobular pneumonia
has_obo_namespace: disease_ontology
id: DOID:12375
in subset: NCIthesaurus

spinal muscular atrophy
type: Class
subclass of: motor neuron disease
textual definition: A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy.
imported from: doid.owl
has cross-reference: GARD:7674
has cross-reference: ICD10CM:G12.9
has cross-reference: ICD9CM:335.1
has cross-reference: MESH:D009134
has cross-reference: NCI:C85075
has cross-reference: SNOMEDCT_US_2020_03_01:5262007
has cross-reference: UMLS_CUI:C0026847
has_obo_namespace: disease_ontology
id: DOID:12377
in subset: DO FlyBase slim
in subset: NCIthesaurus

complex partial epilepsy
type: Class
subclass of: focal epilepsy
imported from: doid.owl
has cross-reference: MESH:D017029
has cross-reference: SNOMEDCT_US_2020_03_01:307358009
has cross-reference: UMLS_CUI:C0085417
alternative_term: Complex partial epileptic seizure
alternative_term: Psychomotor epilepsy
alternative_term: epilepsy, psychomotor
alternative_term: psychomotor epilepsy
has_obo_namespace: disease_ontology
id: DOID:12382

dysentery
type: Class
subclass of: intestinal infectious disease
textual definition: An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood.
imported from: doid.owl
has cross-reference: ICD9CM:009.2
has cross-reference: MESH:D004403
has cross-reference: SNOMEDCT_US_2020_03_01:154268000
has cross-reference: UMLS_CUI:C0013369
alternative_term: Infectious diarrhea
has_obo_namespace: disease_ontology
id: DOID:12384

shigellosis
type: Class
subclass of: primary bacterial infectious disease
subclass of: colonic disease
textual definition: A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.
imported from: doid.owl
has_alternative_id: DOID:11378
has_alternative_id: DOID:12950
has_alternative_id: DOID:2041
has_alternative_id: DOID:924
has_alternative_id: DOID:925
has cross-reference: GARD:4818
has cross-reference: ICD10CM:A03
has cross-reference: ICD10CM:A03.0
has cross-reference: ICD10CM:A03.1
has cross-reference: ICD10CM:A03.2
has cross-reference: ICD9CM:004
has cross-reference: ICD9CM:004.0
has cross-reference: ICD9CM:004.1
has cross-reference: ICD9CM:004.2
has cross-reference: KEGG:05131
has cross-reference: MESH:D004405
has cross-reference: NCI:C157978
has cross-reference: SNOMEDCT_US_2020_03_01:111817006
has cross-reference: SNOMEDCT_US_2020_03_01:34335000
has cross-reference: SNOMEDCT_US_2020_03_01:55760004
has cross-reference: SNOMEDCT_US_2020_03_01:66301008
has cross-reference: UMLS_CUI:C0013371
has cross-reference: UMLS_CUI:C0302358
has cross-reference: UMLS_CUI:C0302359
has cross-reference: UMLS_CUI:C0302360
alternative_term: Shigella boydii infectious disease
alternative_term: Shigella flexneri infectious disease
alternative_term: Shigella gastroenteritis
alternative_term: Shigella sonnei infectious disease
alternative_term: bacillary dysentery
has_obo_namespace: disease_ontology
id: DOID:12385

nephrogenic diabetes insipidus
type: Class
subclass of: kidney disease
textual definition: A kidney disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH).
imported from: doid.owl
has cross-reference: GARD:7178
has cross-reference: ICD10CM:N25.1
has cross-reference: ICD9CM:588.1
has cross-reference: MESH:D018500
has cross-reference: NCI:C84919
has cross-reference: OMIM:125800
has cross-reference: OMIM:304800
has cross-reference: ORDO:223
has cross-reference: SNOMEDCT_US_2020_03_01:123294004
has cross-reference: UMLS_CUI:C0162283
has_obo_namespace: disease_ontology
has_related_synonym: vasopressin-resistant diabetes insipidus
id: DOID:12387
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS].

neurohypophyseal diabetes insipidus
type: Class
subclass of: pancreas disease
imported from: doid.owl
has cross-reference: MESH:D020790
has cross-reference: NCI:C84933
has cross-reference: OMIM:125700
has cross-reference: OMIM:304900
has cross-reference: SNOMEDCT_US_2020_03_01:267393007
has cross-reference: UMLS_CUI:C0687720
alternative_term: Pituitary diabetes insipidus
alternative_term: Vasopressin deficiency
alternative_term: central diabetes insipidus
alternative_term: vasopressin defective diabetes insipidus
has_obo_namespace: disease_ontology
id: DOID:12388
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

entropion
type: Class
subclass of: eyelid disease
imported from: doid.owl
has_alternative_id: DOID:14446
has cross-reference: ICD9CM:374.00
has cross-reference: MESH:D004774
has cross-reference: SNOMEDCT_US_2020_03_01:246821008
has cross-reference: UMLS_CUI:C0014390
has_obo_namespace: disease_ontology
id: DOID:12397

pathological gambling
type: Class
subclass of: impulse control disorder
textual definition: An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.
imported from: doid.owl
has cross-reference: ICD10CM:F63.0
has cross-reference: ICD9CM:312.31
has cross-reference: MESH:D005715
has cross-reference: NCI:C94335
has cross-reference: OMIM:606349
has cross-reference: SNOMEDCT_US_2020_03_01:18085000
has cross-reference: UMLS_CUI:C0030662
alternative_term: Compulsive gambling
alternative_term: Pathological gambling
has_obo_namespace: disease_ontology
id: DOID:12399
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

leukemia
type: Class
subclass of: hematologic cancer
textual definition: A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.
imported from: doid.owl
has_alternative_id: DOID:9145
has cross-reference: ICD10CM:C95.90
has cross-reference: ICD9CM:208
has cross-reference: MESH:D007938
has cross-reference: NCI:C3161
has cross-reference: SNOMEDCT_US_2020_03_01:255049003
has cross-reference: UMLS_CUI:C0023418
has_obo_namespace: disease_ontology
id: DOID:1240
in subset: DO cancer slim
in subset: NCIthesaurus

kleptomania
type: Class
subclass of: impulse control disorder
textual definition: An impulse control disorder that involves the repeated impulse to steal for no great gain, when he or she has sufficient money to pay for the item and no need for what is stolen.
imported from: doid.owl
has cross-reference: ICD10CM:F63.2
has cross-reference: ICD9CM:312.32
has cross-reference: MESH:D007174
has cross-reference: NCI:C94333
has cross-reference: SNOMEDCT_US_2020_03_01:69361009
has cross-reference: UMLS_CUI:C0022734
alternative_term: Pathological stealing
has_obo_namespace: disease_ontology
id: DOID:12400
in subset: NCIthesaurus

intermittent explosive disorder
type: Class
subclass of: impulse control disorder
textual definition: An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.
imported from: doid.owl
has_alternative_id: DOID:9404
has cross-reference: ICD10CM:F60.3
has cross-reference: ICD10CM:F63.81
has cross-reference: ICD9CM:301.3
has cross-reference: ICD9CM:312.34
has cross-reference: MESH:D007174
has cross-reference: NCI:C94332
has cross-reference: SNOMEDCT_US_2020_03_01:192096007
has cross-reference: SNOMEDCT_US_2020_03_01:268757006
has cross-reference: UMLS_CUI:C0021776
has cross-reference: UMLS_CUI:C0152183
alternative_term: explosive personality disorder
has_obo_namespace: disease_ontology
id: DOID:12401
in subset: NCIthesaurus

pyromania
type: Class
subclass of: impulse control disorder
textual definition: An impulse control disorder that involves the uncontrollable impulse to repeatedly set fires with no obvious motive.
imported from: doid.owl
has cross-reference: ICD10CM:F63.1
has cross-reference: ICD9CM:312.33
has cross-reference: MESH:D005391
has cross-reference: NCI:C94334
has cross-reference: SNOMEDCT_US_2020_03_01:600009
has cross-reference: UMLS_CUI:C0016142
alternative_term: Pathological firesetting
alternative_term: firesetting behavior
has_obo_namespace: disease_ontology
id: DOID:12402
in subset: NCIthesaurus

tinea pedis
type: Class
subclass of: skin disease
subclass of: DOID 8913
textual definition: A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot.
imported from: doid.owl
has cross-reference: ICD10CM:B35.3
has cross-reference: ICD9CM:110.4
has cross-reference: MESH:D014008
has cross-reference: SNOMEDCT_US_2020_03_01:186993002
has cross-reference: UMLS_CUI:C0040259
alternative_term: Athlete's foot
alternative_term: Dermatophytosis of foot
has_obo_namespace: disease_ontology
has_related_synonym: ringworm of foot
id: DOID:12403

globe disease
type: Class
subclass of: eye disease
textual definition: An eye disease that involves the globe of the eye.
imported from: doid.owl
has cross-reference: ICD10CM:H44.39
has cross-reference: ICD9CM:360.29
has cross-reference: SNOMEDCT_US_2020_03_01:194638007
has cross-reference: UMLS_CUI:C0154780
has_obo_namespace: disease_ontology
id: DOID:1242

conjugate gaze palsy
type: Class
subclass of: strabismus
imported from: doid.owl
has cross-reference: ICD9CM:378.81
has cross-reference: SNOMEDCT_US_2020_03_01:1534008
has cross-reference: UMLS_CUI:C0702143
alternative_term: Palsy of conjugate gaze
has_obo_namespace: disease_ontology
id: DOID:12445

aplastic anemia
type: Class
subclass of: anemia
textual definition: An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.
imported from: doid.owl
has cross-reference: GARD:5836
has cross-reference: ICD10CM:D61.9
has cross-reference: ICD9CM:284.9
has cross-reference: MESH:D000741
has cross-reference: NCI:C2870
has cross-reference: OMIM:609135
has cross-reference: SNOMEDCT_US_2020_03_01:154807001
has cross-reference: UMLS_CUI:C0002874
has_obo_namespace: disease_ontology
id: DOID:12449
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

vulva cancer
type: Class
subclass of: female reproductive organ cancer
subclass of: vulvar disease
textual definition: A female reproductive organ cancer that is located_in the vulva.
imported from: doid.owl
has_alternative_id: DOID:1282
has cross-reference: GARD:9349
has cross-reference: ICD10CM:C51
has cross-reference: ICD9CM:184.4
has cross-reference: MESH:D014846
has cross-reference: NCI:C3443
has cross-reference: NCI:C7502
has cross-reference: SNOMEDCT_US_2020_03_01:126922007
has cross-reference: SNOMEDCT_US_2020_03_01:94143002
has cross-reference: UMLS_CUI:C0042995
has cross-reference: UMLS_CUI:C0375071
alternative_term: Ca vulva
alternative_term: Vulvar tumor
alternative_term: malignant Vulvar tumor
alternative_term: malignant neoplasm of vulva
alternative_term: malignant tumor of vulva
alternative_term: neoplasm of vulva
alternative_term: vulval cancer
alternative_term: vulval neoplasm
alternative_term: vulvar neoplasm
has_obo_namespace: disease_ontology
id: DOID:1245
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

pancytopenia
type: Class
subclass of: anemia
textual definition: An anemia that is characterized by a reduction in the number of red blood cells, white blood cells, and platelets.
imported from: doid.owl
has cross-reference: ICD10CM:D61.81
has cross-reference: ICD9CM:284.1
has cross-reference: MESH:D010198
has cross-reference: NCI:C34889
has cross-reference: SNOMEDCT_US_2020_03_01:127034005
has cross-reference: UMLS_CUI:C0030312
has_obo_namespace: disease_ontology
id: DOID:12450
in subset: NCIthesaurus

sulfhemoglobinemia
type: Class
subclass of: blood protein disease
imported from: doid.owl
has cross-reference: MESH:D013436
has cross-reference: SNOMEDCT_US_2020_03_01:32117000
has cross-reference: UMLS_CUI:C0038732
alternative_term: Sulfemoglobinemia
alternative_term: Sulfhemoglobinemia
has_obo_namespace: disease_ontology
id: DOID:12451

blood coagulation disease
type: Class
subclass of: hematopoietic system disease
textual definition: A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding.
imported from: doid.owl
has_alternative_id: DOID:13997
has_alternative_id: DOID:2212
has_alternative_id: DOID:9474
has cross-reference: ICD10CM:D68.9
has cross-reference: ICD9CM:286
has cross-reference: MESH:D001778
has cross-reference: NCI:C2902
has cross-reference: SNOMEDCT_US_2020_03_01:64779008
has cross-reference: UMLS_CUI:C0005779
alternative_term: coagulation protein disease
alternative_term: postpartum coagulation defect
alternative_term: postpartum coagulation defect with delivery
has_narrow_synonym: inherited blood coagulation disease
has_obo_namespace: disease_ontology
id: DOID:1247
in subset: NCIthesaurus

capillariasis
type: Class
subclass of: liver disease
subclass of: intestinal disease
subclass of: lung disease
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species.
imported from: doid.owl
has cross-reference: ICD10CM:B81.1
has cross-reference: ICD9CM:127.5
has cross-reference: MESH:D017189
has cross-reference: SNOMEDCT_US_2020_03_01:52979002
has cross-reference: UMLS_CUI:C0006897
alternative_term: Capillaria infection
has_obo_namespace: disease_ontology
id: DOID:12474

Bell's palsy
type: Class
subclass of: facial paralysis
textual definition: A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).
imported from: doid.owl
has cross-reference: GARD:5906
has cross-reference: ICD10CM:G51.0
has cross-reference: ICD9CM:351.0
has cross-reference: MESH:D020330
has cross-reference: SNOMEDCT_US_2020_03_01:193093009
has cross-reference: UMLS_CUI:C0376175
alternative_term: Bell palsy
alternative_term: Bell's (facial) palsy
has_obo_namespace: disease_ontology
id: DOID:12506

tuberculous epididymitis
type: Class
subclass of: epididymis disease
subclass of: urogenital tuberculosis
textual definition: An urogenital tuberculosis that is located_in epididymis, has_symptom pain and has_symptom scrotal swelling.
imported from: doid.owl
has cross-reference: ICD9CM:016.4
has cross-reference: SNOMEDCT_US_2020_03_01:83652003
has cross-reference: UMLS_CUI:C0152814
has_obo_namespace: disease_ontology
id: DOID:1251
in subset: gram-positive bacterial infectious disease

retinal perforation
type: Class
subclass of: retinal detachment
imported from: doid.owl
has cross-reference: MESH:D012167
has cross-reference: NCI:C50732
has cross-reference: SNOMEDCT_US_2020_03_01:40024006
has cross-reference: UMLS_CUI:C0035321
alternative_term: Retinal break
alternative_term: Retinal dialysis
alternative_term: Retinal tear
has_obo_namespace: disease_ontology
id: DOID:12514
in subset: NCIthesaurus

trichuriasis
type: Class
subclass of: intestinal disease
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.
imported from: doid.owl
has cross-reference: GARD:10720
has cross-reference: ICD10CM:B79
has cross-reference: ICD9CM:127.3
has cross-reference: MESH:D014257
has cross-reference: NCI:C128399
has cross-reference: SNOMEDCT_US_2020_03_01:60570001
has cross-reference: UMLS_CUI:C0040954
alternative_term: Infection by Trichuris trichura
alternative_term: Trichuriasis infection
alternative_term: Whipworm disease
alternative_term: trichuris trichiura infection
has_obo_namespace: disease_ontology
id: DOID:1252
in subset: NCIthesaurus

tarsal tunnel syndrome
type: Class
subclass of: tibial neuropathy
imported from: doid.owl
has cross-reference: GARD:7733
has cross-reference: ICD10CM:G57.5
has cross-reference: ICD9CM:355.5
has cross-reference: MESH:D013641
has cross-reference: NCI:C85183
has cross-reference: SNOMEDCT_US_2020_03_01:155077008
has cross-reference: UMLS_CUI:C0039319
has_obo_namespace: disease_ontology
id: DOID:12526
in subset: NCIthesaurus

von Willebrand's disease
type: Class
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is a hereditary abnormality which slows the blood clotting process. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion.
imported from: doid.owl
has cross-reference: GARD:7867
has cross-reference: ICD10CM:D68.0
has cross-reference: ICD9CM:286.4
has cross-reference: MESH:D014842
has cross-reference: NCI:C68677
has cross-reference: SNOMEDCT_US_2020_03_01:11093006
has cross-reference: UMLS_CUI:C0042974
alternative_term: vascular hemophilia
alternative_term: vascular pseudohemophilia
alternative_term: von Willebrand disease
alternative_term: von Willebrand disorder
alternative_term: von Willebrand's-Jurgens' disease
alternative_term: von Willebrand-Jrgens disease
has_obo_namespace: disease_ontology
id: DOID:12531
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

trichostrongylosis
type: Class
subclass of: trichostrongyloidiasis
textual definition: A trichostrongyloidiasis that involves infection of the small intestine with Trichostrongylus colubriformis or Trichostrongylus axei, which results in abdominal pain, diarrhea, anorexia, headache, fatigue, anemia and eosinophilia.
imported from: doid.owl
has cross-reference: ICD10CM:B81.2
has cross-reference: ICD9CM:127.6
has cross-reference: MESH:D014253
has cross-reference: SNOMEDCT_US_2020_03_01:33710003
has cross-reference: UMLS_CUI:C0040948
alternative_term: Infection by Trichostrongylus
alternative_term: Infection by Trichostrongylus species
alternative_term: Trichostrongyliasis
has_obo_namespace: disease_ontology
id: DOID:1254

hepatitis A
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.
imported from: doid.owl
has_alternative_id: DOID:12547
has cross-reference: MESH:D006506
has cross-reference: NCI:C3096
has cross-reference: SNOMEDCT_US_2020_03_01:40468003
has cross-reference: UMLS_CUI:C0019159
alternative_term: Viral hepatitis, type A
has_obo_namespace: disease_ontology
has_related_synonym: Viral hepatitis A
id: DOID:12549
in subset: NCIthesaurus

trichostrongyloidiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by nematodes of the superfamily Trichostrongyloidea.
imported from: doid.owl
has cross-reference: MESH:D014252
has cross-reference: UMLS_CUI:C0040947
has_obo_namespace: disease_ontology
id: DOID:1255

hemolytic-uremic syndrome
type: Class
subclass of: kidney disease
textual definition: A kidney disease that is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs.
imported from: doid.owl
has cross-reference: GARD:6588
has cross-reference: ICD10CM:D59.3
has cross-reference: ICD9CM:283.11
has cross-reference: MESH:D006463
has cross-reference: NCI:C75545
has cross-reference: ORDO:2134
has cross-reference: SNOMEDCT_US_2020_03_01:123308008
has cross-reference: UMLS_CUI:C0019061
alternative_term: haemolytic-uraemic syndrome
alternative_term: hemolytic uremic syndrome
has_obo_namespace: disease_ontology
id: DOID:12554
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

Duane retraction syndrome
type: Class
subclass of: strabismus
imported from: doid.owl
has cross-reference: ICD10CM:H50.81
has cross-reference: ICD9CM:378.71
has cross-reference: MESH:D004370
has cross-reference: NCI:C84678
has cross-reference: OMIM:126800
has cross-reference: OMIM:604356
has cross-reference: ORDO:233
has cross-reference: SNOMEDCT_US_2020_03_01:60318001
has cross-reference: UMLS_CUI:C0013261
alternative_term: Duane's syndrome
alternative_term: Stilling-Turk-Duane syndrome
has_obo_namespace: disease_ontology
id: DOID:12557
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chronic progressive external ophthalmoplegia
type: Class
subclass of: mitochondrial myopathy
imported from: doid.owl
has cross-reference: GARD:4503
has cross-reference: ICD10CM:H49.4
has cross-reference: ICD9CM:378.72
has cross-reference: MESH:D017246
has cross-reference: OMIM:PS157640
has cross-reference: SNOMEDCT_US_2020_03_01:194126004
has cross-reference: UMLS_CUI:C0162674
alternative_term: progressive external ophthalmoplegia
has_obo_namespace: disease_ontology
id: DOID:12558

idiopathic juvenile osteoporosis
type: Class
subclass of: osteoporosis
textual definition: An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.
imported from: doid.owl
has cross-reference: ICD9CM:733.02
has cross-reference: OMIM:259750
has cross-reference: SNOMEDCT_US_2020_03_01:3345002
has cross-reference: UMLS_CUI:C0158447
alternative_term: Idiopathic osteoporosis
alternative_term: juvenile osteoporosis
has_obo_namespace: disease_ontology
id: DOID:12559

dyscalculia
type: Class
subclass of: DOID 8927
textual definition: A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page.
imported from: doid.owl
has cross-reference: MESH:D060705
alternative_term: Mathematics disorder
alternative_term: disorder of arithmetical skills
has_obo_namespace: disease_ontology
id: DOID:12568

phacogenic glaucoma
type: Class
subclass of: glaucoma
textual definition: A glaucoma characterized by glaucomatous optic atrophy secondary to a lens abnormality and has_symptom progressive decreased vision, especially decreased peripheral vision. Phacogenic glaucoma can be caused by cataracts, trauma to the eye, or age-related damage that obstructs aqueous outflow, leading to inappropriately increased intraocular pressure and eventual optic nerve atrophy with associated vision loss.
imported from: doid.owl
has cross-reference: ICD9CM:365.59
has cross-reference: SNOMEDCT_US_2020_03_01:84333006
has cross-reference: UMLS_CUI:C0154959
has_obo_namespace: disease_ontology
id: DOID:12571

neonatal thyrotoxicosis
type: Class
subclass of: thyrotoxicosis
imported from: doid.owl
has cross-reference: ICD10CM:P72.1
has cross-reference: ICD9CM:775.3
has cross-reference: NCI:C114906
has cross-reference: SNOMEDCT_US_2020_03_01:13795004
has cross-reference: UMLS_CUI:C0158983
alternative_term: Neonatal thyrotoxicosis
has_obo_namespace: disease_ontology
id: DOID:12573
in subset: NCIthesaurus

urethral obstruction
type: Class
subclass of: urethral disease
imported from: doid.owl
has cross-reference: MESH:D014524
has cross-reference: NCI:C79804
has cross-reference: SNOMEDCT_US_2020_03_01:95588004
has cross-reference: UMLS_CUI:C0041972
alternative_term: Obstruction of urethra
has_obo_namespace: disease_ontology
id: DOID:12577
in subset: NCIthesaurus

Cri-Du-Chat syndrome
type: Class
subclass of: chromosomal deletion syndrome
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in deletion of the end of the chromosome 5 p arm and that is characterized by intellectual disability, delayed development, small head size, low birth weight, weak muscle tone widely set eyes, low-set ears, a small jaw, a rounded face and a high-pitched cry that sounds like that of a cat.
imported from: doid.owl
has cross-reference: GARD:6213
has cross-reference: ICD10CM:Q93.4
has cross-reference: ICD9CM:758.31
has cross-reference: MESH:D003410
has cross-reference: NCI:C34518
has cross-reference: OMIM:123450
has cross-reference: SNOMEDCT_US_2020_03_01:70173007
has cross-reference: UMLS_CUI:C0010314
alternative_term: 5p deletion syndrome
alternative_term: 5p partial monosomy syndrome
alternative_term: Cri-du-chat syndrome
alternative_term: chromosome 5 short arm deletion syndrome
alternative_term: chromosome 5p deletion syndrome
has_obo_namespace: disease_ontology
id: DOID:12580
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

velocardiofacial syndrome
type: Class
subclass of: chromosomal deletion syndrome
textual definition: A chromosomal deletion disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and that is characterized by variable developmental problems and schizoid features.
imported from: doid.owl
has cross-reference: ICD10CM:Q93.81
has cross-reference: ICD9CM:758.32
has cross-reference: MESH:D004062
has cross-reference: OMIM:192430
has cross-reference: SNOMEDCT_US_2020_03_01:205642004
has cross-reference: UMLS_CUI:C0220704
alternative_term: 22q11 Deletion Syndrome
alternative_term: Shprintzen syndrome
alternative_term: VCF-Velocardiofacial syndrome
alternative_term: deletion 22q11.2 syndrome
has_obo_namespace: disease_ontology
id: DOID:12583
comment: OMIM mapping confirmed by DO. [LS].

Potter's syndrome
type: Class
subclass of: renal agenesis
textual definition: A renal agenesis characterized by the typical physical appearance and associated pulmonary hypoplasia of a newborn as a direct result of kidney failure, oligohydramnios and compression while in the uterus.
imported from: doid.owl
has cross-reference: GARD:4462
has cross-reference: ICD10CM:Q60.6
has cross-reference: NCI:C40435
has cross-reference: SNOMEDCT_US_2020_03_01:41962002
has cross-reference: UMLS_CUI:C0178426
alternative_term: Potter sequence
alternative_term: Potter syndrome
has_obo_namespace: disease_ontology
id: DOID:12594
in subset: NCIthesaurus

parametritis
type: Class
subclass of: pelvic inflammatory disease
imported from: doid.owl
has cross-reference: MESH:D010249
has cross-reference: SNOMEDCT_US_2020_03_01:280483007
has cross-reference: UMLS_CUI:C0030455
alternative_term: pelvic cellulitis
has_obo_namespace: disease_ontology
id: DOID:1260

acute leukemia
type: Class
subclass of: lymphoid leukemia
textual definition: A lymphoid leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity producing large numbers of white blood cells to be produced and enter the blood stream.
imported from: doid.owl
has_alternative_id: DOID:12621
has cross-reference: ICD10CM:C95.00
has cross-reference: ICD9CM:208.0
has cross-reference: NCI:C9300
has cross-reference: OMIM:308960
has cross-reference: SNOMEDCT_US_2020_03_01:24072005
has cross-reference: UMLS_CUI:C0085669
has cross-reference: UMLS_CUI:C1378511
alternative_term: Stem cell Leukemia
alternative_term: Stem cell leukaemia
has_obo_namespace: disease_ontology
id: DOID:12603
in subset: NCIthesaurus

pyloric stenosis
type: Class
subclass of: gastric outlet obstruction
imported from: doid.owl
has cross-reference: ICD10CM:K31.1
has cross-reference: MESH:D011707
has cross-reference: NCI:C34966
has cross-reference: SNOMEDCT_US_2020_03_01:367403001
has cross-reference: UMLS_CUI:C0034194
has_obo_namespace: disease_ontology
id: DOID:12639
in subset: NCIthesaurus

hiatus hernia
type: Class
subclass of: stomach disease
imported from: doid.owl
has cross-reference: ICD10CM:K44
has cross-reference: MESH:D006551
has cross-reference: NCI:C98945
has cross-reference: OMIM:142400
has cross-reference: SNOMEDCT_US_2020_03_01:236053002
has cross-reference: SNOMEDCT_US_2020_03_01:3662000
has cross-reference: SNOMEDCT_US_2020_03_01:84089009
has cross-reference: UMLS_CUI:C0267725
has cross-reference: UMLS_CUI:C0376710
has cross-reference: UMLS_CUI:C3489393
alternative_term: Diaphragmatic - hiatus -hernia
alternative_term: hiatal hernia
has_obo_namespace: disease_ontology
id: DOID:12642
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

vestibulocochlear nerve disease
type: Class
subclass of: retrocochlear disease
subclass of: cranial nerve disease
imported from: doid.owl
has cross-reference: ICD10CM:H93.3
has cross-reference: ICD9CM:388.5
has cross-reference: MESH:D000160
has cross-reference: NCI:C27207
has cross-reference: SNOMEDCT_US_2020_03_01:77949003
has cross-reference: UMLS_CUI:C0001163
alternative_term: acoustic nerve disease
has_obo_namespace: disease_ontology
id: DOID:12657
in subset: NCIthesaurus

paracoccidioidomycosis
type: Class
subclass of: primary systemic mycosis
subclass of: bone disease
subclass of: skin disease
subclass of: lung disease
subclass of: DOID 9942
textual definition: A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.
imported from: doid.owl
has cross-reference: GARD:7323
has cross-reference: ICD10CM:B41
has cross-reference: ICD9CM:116.1
has cross-reference: MESH:D010229
has cross-reference: NCI:C34891
has cross-reference: SNOMEDCT_US_2020_03_01:59925007
has cross-reference: UMLS_CUI:C0030409
alternative_term: Mucocutaneous-lymphangitic paracoccidioidomycosis
alternative_term: Paracoccidioidomycosis
alternative_term: paracoccidioidal mycosis
has_obo_namespace: disease_ontology
id: DOID:12662
in subset: NCIthesaurus

blastomycosis
type: Class
subclass of: primary systemic mycosis
textual definition: A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening.
imported from: doid.owl
has_alternative_id: DOID:13067
has cross-reference: GARD:5931
has cross-reference: ICD10CM:B40
has cross-reference: ICD9CM:116.0
has cross-reference: MESH:D001759
has cross-reference: NCI:C34428
has cross-reference: SNOMEDCT_US_2020_03_01:266217003
has cross-reference: UMLS_CUI:C0005716
alternative_term: Blastomyces Dermatitidis Infection
alternative_term: Blastomycotic infection
alternative_term: Chicago disease
alternative_term: Gilchrist's disease
alternative_term: Infection by Blastomyces dermatitidis
alternative_term: North American blastomycosis
has_obo_namespace: disease_ontology
id: DOID:12663
in subset: NCIthesaurus

binocular vision disease
type: Class
subclass of: strabismus
imported from: doid.owl
has_alternative_id: DOID:12671
has cross-reference: ICD10CM:H53.30
has cross-reference: ICD9CM:368.30
has cross-reference: NCI:C34422
has cross-reference: SNOMEDCT_US_2020_03_01:83275001
has cross-reference: UMLS_CUI:C0005461
alternative_term: simultaneous visual perception without fusion
has_obo_namespace: disease_ontology
id: DOID:12667
in subset: NCIthesaurus

abnormal retinal correspondence
type: Class
subclass of: binocular vision disease
imported from: doid.owl
has cross-reference: ICD10CM:H53.31
has cross-reference: ICD9CM:368.34
has cross-reference: SNOMEDCT_US_2020_03_01:79195003
has cross-reference: UMLS_CUI:C0155010
has_obo_namespace: disease_ontology
id: DOID:12668

hypercalcemia
type: Class
subclass of: calcium metabolism disease
imported from: doid.owl
has cross-reference: ICD10CM:E83.52
has cross-reference: ICD9CM:275.42
has cross-reference: MESH:D006934
has cross-reference: NCI:C3112
has cross-reference: SNOMEDCT_US_2020_03_01:154752005
has cross-reference: UMLS_CUI:C0020437
has_obo_namespace: disease_ontology
id: DOID:12678
in subset: NCIthesaurus

nephrocalcinosis
type: Class
subclass of: kidney disease
imported from: doid.owl
has cross-reference: GARD:7177
has cross-reference: MESH:D009397
has cross-reference: NCI:C84918
has cross-reference: SNOMEDCT_US_2020_03_01:154752005
has cross-reference: UMLS_CUI:C0027709
has_obo_namespace: disease_ontology
id: DOID:12679
in subset: NCIthesaurus

pseudobulbar palsy
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by damage to neurons of the corticobulbar tract, has_symptom dysarthria, has_symptom dysphagia, has_symptom spasticity located_in tongue, has_symptom abnormal bulbar reflexes, and has_symptom emotional outbursts.
imported from: doid.owl
has cross-reference: ICD9CM:335.23
has cross-reference: MESH:D020828
has cross-reference: NCI:C129934
has cross-reference: SNOMEDCT_US_2020_03_01:7379000
has cross-reference: UMLS_CUI:C0033790
alternative_term: Pseudobulbar palsy
alternative_term: pseudobulbar paralysis
has_obo_namespace: disease_ontology
id: DOID:12680
in subset: NCIthesaurus

vestibular neuronitis
type: Class
subclass of: vestibulocochlear nerve disease
subclass of: poliomyelitis
textual definition: A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.
imported from: doid.owl
has cross-reference: ICD10CM:H81.2
has cross-reference: ICD9CM:386.12
has cross-reference: MESH:D020338
has cross-reference: SNOMEDCT_US_2020_03_01:232293008
has cross-reference: UMLS_CUI:C0751908
alternative_term: Epidemic neurolabyrinthitis
alternative_term: Vestibular neuritis
has_obo_namespace: disease_ontology
id: DOID:12683

acoustic neuroma
type: Class
subclass of: neurilemmoma
imported from: doid.owl
has cross-reference: GARD:223
has cross-reference: MESH:D009464
has cross-reference: NCI:C3276
has cross-reference: SNOMEDCT_US_2020_03_01:269643009
has cross-reference: UMLS_CUI:C0027859
alternative_term: Vestibular Neurilemmoma
alternative_term: Vestibular schwannoma
has_obo_namespace: disease_ontology
id: DOID:12689
in subset: NCIthesaurus

locked-in syndrome
type: Class
subclass of: DOID 863
textual definition: A nervous system disease that is characterized by complete paralysis of all voluntary muscles except for the ones that control the movements of the eyes.
imported from: doid.owl
has cross-reference: GARD:6919
has cross-reference: ICD10CM:G83.5
has cross-reference: ICD9CM:344.81
has cross-reference: MESH:D000080422
has cross-reference: SNOMEDCT_US_2020_03_01:38023001
has cross-reference: UMLS_CUI:C0023944
alternative_term: Locked in syndrome
alternative_term: Locked-in state
has_obo_namespace: disease_ontology
id: DOID:12697
in subset: DO rare slim

gynecomastia
type: Class
subclass of: disorder of sexual development
textual definition: A disorder of sexual development that is characterized by enlargement or swelling of male breast tissue resulting from elevated male estrogen levels or imbalanced estrogen and testosterone levels.
imported from: doid.owl
has cross-reference: ICD10CM:N62
has cross-reference: MESH:D006177
has cross-reference: NCI:C3073
has cross-reference: SNOMEDCT_US_2020_03_01:155963008
has cross-reference: UMLS_CUI:C0018418
has_obo_namespace: disease_ontology
id: DOID:12698
in subset: NCIthesaurus

leiomyoma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm that is a benign tumor of smooth muscle cells.
imported from: doid.owl
has cross-reference: MESH:D007889
has cross-reference: NCI:C3157
has cross-reference: SNOMEDCT_US_2020_03_01:702978006
has cross-reference: UMLS_CUI:C0023267
alternative_term: leiomyomatous neoplasm
alternative_term: leiomyomatous tumor
has_obo_namespace: disease_ontology
id: DOID:127
in subset: NCIthesaurus

hereditary hemorrhagic telangiectasia
type: Class
subclass of: autosomal dominant disease
subclass of: vascular disease
textual definition: A vascular disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins.
imported from: doid.owl
has cross-reference: GARD:6626
has cross-reference: ICD10CM:I78.0
has cross-reference: ICD9CM:448.0
has cross-reference: MESH:D013683
has cross-reference: NCI:C35064
has cross-reference: OMIM:187300
has cross-reference: OMIM:600376
has cross-reference: OMIM:601101
has cross-reference: OMIM:615506
has cross-reference: ORDO:774
has cross-reference: SNOMEDCT_US_2020_03_01:266324004
has cross-reference: UMLS_CUI:C0039445
alternative_term: Osler hemorrhagic telangiectasia syndrome
alternative_term: Osler-Weber-Rendu disease
alternative_term: Rendu-Osler-Weber disease
has_obo_namespace: disease_ontology
id: DOID:1270
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

hyperprolactinemia
type: Class
subclass of: acquired metabolic disease
textual definition: An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.
imported from: doid.owl
has_alternative_id: DOID:12699
has cross-reference: ICD10CM:E22.1
has cross-reference: MESH:D002640
has cross-reference: MESH:D006966
has cross-reference: SNOMEDCT_US_2020_03_01:190468001
has cross-reference: SNOMEDCT_US_2020_03_01:85039006
has cross-reference: UMLS_CUI:C0008043
has cross-reference: UMLS_CUI:C0020514
alternative_term: Chiari-Frommel syndrome
alternative_term: Pregnancy-related A-G syndrome
alternative_term: hyperprolactinaemia
has_obo_namespace: disease_ontology
id: DOID:12700
in subset: NCIthesaurus

ataxia telangiectasia
type: Class
subclass of: autosomal recessive cerebellar ataxia
textual definition: An autosomal recessive cerebellar ataxia that is characterized by cerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancy and that has_material_basis_in homozygous or compound heterozygous mutation in the ATM gene on chromosome 11q22.
imported from: doid.owl
has cross-reference: GARD:5862
has cross-reference: MESH:D001260
has cross-reference: NCI:C2887
has cross-reference: OMIM:208900
has cross-reference: SNOMEDCT_US_2020_03_01:68504005
has cross-reference: UMLS_CUI:C0004135
alternative_term: Boder-Sedgwick syndrome
alternative_term: Louis Bar syndrome
has_obo_namespace: disease_ontology
id: DOID:12704
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Friedreich ataxia
type: Class
subclass of: autosomal recessive cerebellar ataxia
imported from: doid.owl
has_alternative_id: DOID:0050555
has cross-reference: GARD:6468
has cross-reference: ICD9CM:334.0
has cross-reference: MESH:D005621
has cross-reference: NCI:C84718
has cross-reference: SNOMEDCT_US_2020_03_01:155011003
has cross-reference: UMLS_CUI:C0016719
alternative_term: Friedreich ataxia 1
alternative_term: Friedreich's ataxia
alternative_term: Friedreich's tabes
has_obo_namespace: disease_ontology
id: DOID:12705
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: Xref MGI.

capillary disease
type: Class
subclass of: vascular disease
textual definition: A vascular disease that is located_in the capillaries.
imported from: doid.owl
has cross-reference: ICD10CM:I78
has cross-reference: ICD9CM:448
has cross-reference: SNOMEDCT_US_2020_03_01:58729003
has cross-reference: UMLS_CUI:C0155765
alternative_term: disease of capillaries
has_obo_namespace: disease_ontology
id: DOID:1271

nephronophthisis
type: Class
subclass of: autosomal recessive disease
subclass of: kidney disease
textual definition: A kidney disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy).
imported from: doid.owl
has cross-reference: GARD:206
has cross-reference: ICD10CM:Q61.5
has cross-reference: NCI:C123200
has cross-reference: OMIM:PS256100
has cross-reference: ORDO:655
has cross-reference: SNOMEDCT_US_2020_03_01:204958008
has cross-reference: UMLS_CUI:C0687120
alternative_term: medullary cystic disease
alternative_term: medullary cystic kidney
has_obo_namespace: disease_ontology
id: DOID:12712
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Ellis-Van Creveld syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by short limbs, short ribs, postaxial polydactyly, dysplastic nails and teeth, and in many patients congenital cardiac defects that has_material_basis_in homozygous or compound heterozygous mutation in either EVC or EVC2 on chromosome 4p16.2.
imported from: doid.owl
has cross-reference: GARD:1301
has cross-reference: ICD10CM:Q77.6
has cross-reference: ICD9CM:756.55
has cross-reference: MESH:D004613
has cross-reference: NCI:C84684
has cross-reference: OMIM:225500
has cross-reference: SNOMEDCT_US_2020_03_01:62501005
has cross-reference: UMLS_CUI:C0013903
alternative_term: Chondroectodermal dysplasia
alternative_term: Ellis-van Creveld syndrome
alternative_term: mesoectodermal dysplasia
has_obo_namespace: disease_ontology
id: DOID:12714
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

newborn respiratory distress syndrome
type: Class
subclass of: respiratory failure
textual definition: A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.
imported from: doid.owl
has_alternative_id: DOID:11395
has_alternative_id: DOID:13859
has cross-reference: ICD10CM:P22.0
has cross-reference: MESH:D006819
has cross-reference: OMIM:267450
has cross-reference: SNOMEDCT_US_2020_03_01:26168007
has cross-reference: UMLS_CUI:C0020192
alternative_term: HMD - Hyaline membrane disease
alternative_term: Neonatal respiratory Distress syndrome
alternative_term: hyaline membrane disease
alternative_term: pulmonary hyaline membrane disease
alternative_term: pulmonary hypoperfusion syndrome of newborn
alternative_term: respiratory distress syndrome of newborn
has_obo_namespace: disease_ontology
id: DOID:12716

telangiectasis
type: Class
subclass of: peripheral vascular disease
imported from: doid.owl
has cross-reference: MESH:D013684
has cross-reference: NCI:C28194
has cross-reference: SNOMEDCT_US_2020_03_01:112641009
has cross-reference: UMLS_CUI:C0039446
alternative_term: telangiectasia
has_obo_namespace: disease_ontology
id: DOID:1272
in subset: NCIthesaurus

cerebral atherosclerosis
type: Class
subclass of: atherosclerosis
imported from: doid.owl
has cross-reference: ICD10CM:I67.2
has cross-reference: ICD9CM:437.0
has cross-reference: MESH:D002537
has cross-reference: NCI:C34459
has cross-reference: SNOMEDCT_US_2020_03_01:266258005
has cross-reference: UMLS_CUI:C0007775
alternative_term: Cerebral atherosclerosis
has_obo_namespace: disease_ontology
id: DOID:12720
in subset: NCIthesaurus

multiple epiphyseal dysplasia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results in irregular ossification centers of the located in hip or located in knee. The disease has symptom fatigue, has symptom joint pain.
imported from: doid.owl
has cross-reference: GARD:10756
has cross-reference: ICD9CM:756.56
has cross-reference: MESH:D010009
has cross-reference: ORDO:251
has cross-reference: SNOMEDCT_US_2020_03_01:59708000
has cross-reference: UMLS_CUI:C0026760
alternative_term: polyepiphyseal dysplasia
has_obo_namespace: disease_ontology
id: DOID:12721
in subset: DO rare slim
comment: Xref MGI.

respiratory syncytial virus infectious disease
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.
imported from: doid.owl
has cross-reference: MESH:D018357
has cross-reference: NCI:C3354
has cross-reference: SNOMEDCT_US_2020_03_01:186750007
has cross-reference: UMLS_CUI:C0035235
has_obo_namespace: disease_ontology
id: DOID:1273
in subset: NCIthesaurus

hypercementosis
type: Class
subclass of: teeth hard tissue disease
imported from: doid.owl
has cross-reference: ICD10CM:K03.4
has cross-reference: ICD9CM:521.5
has cross-reference: MESH:D006936
has cross-reference: SNOMEDCT_US_2020_03_01:78537008
has cross-reference: UMLS_CUI:C0020441
alternative_term: Cementation hyperplasia
has_obo_namespace: disease_ontology
id: DOID:12733

corneal staphyloma
type: Class
subclass of: corneal disease
imported from: doid.owl
has cross-reference: ICD10CM:H18.72
has cross-reference: ICD9CM:371.73
has cross-reference: SNOMEDCT_US_2020_03_01:193849005
has cross-reference: UMLS_CUI:C0152440
has_obo_namespace: disease_ontology
id: DOID:12753

choroid cancer
type: Class
subclass of: choroid disease
subclass of: uveal cancer
imported from: doid.owl
has_alternative_id: DOID:12760
has cross-reference: ICD10CM:C69.3
has cross-reference: ICD9CM:190.6
has cross-reference: MESH:D002830
has cross-reference: NCI:C2949
has cross-reference: NCI:C3566
has cross-reference: SNOMEDCT_US_2020_03_01:127001008
has cross-reference: SNOMEDCT_US_2020_03_01:93755007
has cross-reference: UMLS_CUI:C0008523
has cross-reference: UMLS_CUI:C0153630
alternative_term: Choroidal tumor
alternative_term: choroid neoplasm
alternative_term: malignant tumor of choroid
alternative_term: malignant tumor of the Choroid
alternative_term: neoplasm of choroid
has_obo_namespace: disease_ontology
id: DOID:12759
in subset: NCIthesaurus

tolosa-hunt syndrome
type: Class
subclass of: ocular motility disease
imported from: doid.owl
has cross-reference: GARD:7777
has cross-reference: MESH:D020333
has cross-reference: NCI:C85193
has cross-reference: SNOMEDCT_US_2020_03_01:75111000
has cross-reference: UMLS_CUI:C0040381
alternative_term: Tolosa-Hunt syndrome
has_obo_namespace: disease_ontology
id: DOID:1278
in subset: NCIthesaurus

cicatricial ectropion
type: Class
subclass of: ectropion
imported from: doid.owl
has cross-reference: ICD9CM:374.14
has cross-reference: SNOMEDCT_US_2020_03_01:28914006
has cross-reference: UMLS_CUI:C0155196
has_obo_namespace: disease_ontology
id: DOID:12782

migraine without aura
type: Class
subclass of: migraine
textual definition: A migraine that is characterized by migraine headaches that are not accompanied by an aura.
imported from: doid.owl
has cross-reference: ICD10CM:G43.0
has cross-reference: ICD9CM:346.1
has cross-reference: MESH:D020326
has cross-reference: NCI:C117004
has cross-reference: OMIM:607501
has cross-reference: SNOMEDCT_US_2020_03_01:56097005
has cross-reference: UMLS_CUI:C0338480
alternative_term: common migraine
has_obo_namespace: disease_ontology
id: DOID:12783
in subset: NCIthesaurus
comment: Xref MGI.

ocular motility disease
type: Class
subclass of: eye disease
subclass of: cranial nerve disease
imported from: doid.owl
has cross-reference: GARD:7061
has cross-reference: GARD:7237
has cross-reference: ICD9CM:378.9
has cross-reference: MESH:D015835
has cross-reference: SNOMEDCT_US_2020_03_01:45030009
has cross-reference: UMLS_CUI:C0028850
alternative_term: disorder of eye movements
alternative_term: eye movement disorder
has_obo_namespace: disease_ontology
id: DOID:1279

mucopolysaccharidosis
type: Class
subclass of: lysosomal storage disease
textual definition: A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine.
imported from: doid.owl
has_alternative_id: DOID:14716
has cross-reference: GARD:7065
has cross-reference: ICD10CM:E76.3
has cross-reference: ICD9CM:277.5
has cross-reference: MESH:D009083
has cross-reference: NCI:C61259
has cross-reference: OMIM:252700
has cross-reference: OMIM:PS607014
has cross-reference: ORDO:79213
has cross-reference: SNOMEDCT_US_2020_03_01:267452003
has cross-reference: UMLS_CUI:C0026703
has_obo_namespace: disease_ontology
id: DOID:12798
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS].

mucopolysaccharidosis VI
type: Class
subclass of: mucopolysaccharidosis
textual definition: A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase.
imported from: doid.owl
has cross-reference: GARD:7095
has cross-reference: MESH:D009087
has cross-reference: NCI:C61264
has cross-reference: OMIM:253200
has cross-reference: SNOMEDCT_US_2020_03_01:69463008
has cross-reference: UMLS_CUI:C0026709
alternative_term: MPS VI - Maroteaux-Lamy syndrome
alternative_term: Maroteaux - Lamy syndrome
alternative_term: Maroteaux-Lamy syndrome
alternative_term: arylsulfatase B deficiency
alternative_term: deficiency of N-acetylgalactosamine-4-sulfatase
has_obo_namespace: disease_ontology
id: DOID:12800
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mucopolysaccharidosis III
type: Class
subclass of: mucopolysaccharidosis
textual definition: A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain.
imported from: doid.owl
has_alternative_id: DOID:14729
has_alternative_id: DOID:14788
has cross-reference: MESH:D009084
has cross-reference: NCI:C61262
has cross-reference: OMIM:252940
has cross-reference: ORDO:581
has cross-reference: SNOMEDCT_US_2020_03_01:190936000
has cross-reference: UMLS_CUI:C0026706
alternative_term: Mucopolysaccharidosis, MPS-III
alternative_term: N-sulphoglucosamine sulphohydrolase deficiency
alternative_term: Sanfilippo's syndrome
alternative_term: heparan sulfate sulfatase deficiency
has_narrow_synonym: naglu deficiency
has_obo_namespace: disease_ontology
id: DOID:12801
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mucopolysaccharidosis IV
type: Class
subclass of: mucopolysaccharidosis
textual definition: A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain.
imported from: doid.owl
has_alternative_id: DOID:0050808
has_alternative_id: DOID:14767
has cross-reference: ICD10CM:E76.219
has cross-reference: MESH:D009085
has cross-reference: NCI:C61263
has cross-reference: SNOMEDCT_US_2020_03_01:378007
has cross-reference: UMLS_CUI:C0026707
alternative_term: Mucopolysaccharidosis, MPS-IV
alternative_term: deficiency of N-acetylgalactosamine-6-sulphatase
alternative_term: deficiency of chondroitinsulphatase
alternative_term: galactosamine-6-sulfatase deficiency
has_narrow_synonym: Osteochondrodystrophy
has_narrow_synonym: chondroosteodystrophy
has_obo_namespace: disease_ontology
id: DOID:12804
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

quadriplegia
type: Class
subclass of: central nervous system disease
imported from: doid.owl
has cross-reference: ICD10CM:G82.5
has cross-reference: ICD9CM:344.00
has cross-reference: MESH:D011782
has cross-reference: NCI:C50721
has cross-reference: SNOMEDCT_US_2020_03_01:11538006
has cross-reference: UMLS_CUI:C0034372
alternative_term: tetraplegia
has_obo_namespace: disease_ontology
id: DOID:12835
in subset: NCIthesaurus

thyroid crisis
type: Class
subclass of: thyroid gland disease
imported from: doid.owl
has cross-reference: MESH:D013958
has cross-reference: NCI:C112836
has cross-reference: SNOMEDCT_US_2020_03_01:190262002
has cross-reference: UMLS_CUI:C0040127
alternative_term: Thyroid crisis
alternative_term: Thyrotoxic crisis
has_obo_namespace: disease_ontology
id: DOID:12837
in subset: NCIthesaurus

prolapse of female genital organ
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is characteried by the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening.
imported from: doid.owl
has cross-reference: ICD9CM:618.8
has cross-reference: UMLS_CUI:C0029801
has_obo_namespace: disease_ontology
id: DOID:1284

ancylostomiasis
type: Class
subclass of: skin disease
subclass of: eye disease
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.
imported from: doid.owl
has cross-reference: GARD:9742
has cross-reference: ICD10CM:B76.0
has cross-reference: MESH:D000724
has cross-reference: NCI:C35805
has cross-reference: SNOMEDCT_US_2020_03_01:85807000
has cross-reference: UMLS_CUI:C0002831
has_obo_namespace: disease_ontology
id: DOID:12841
in subset: NCIthesaurus

Guillain-Barre syndrome
type: Class
subclass of: autoimmune disease of peripheral nervous system
textual definition: An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.
imported from: doid.owl
has cross-reference: GARD:6554
has cross-reference: ICD10CM:G61.0
has cross-reference: MESH:D020275
has cross-reference: NCI:C116345
has cross-reference: OMIM:139393
has cross-reference: SNOMEDCT_US_2020_03_01:155082001
has cross-reference: UMLS_CUI:C0018378
alternative_term: Infectious neuronitis
alternative_term: Post-infectious polyneuritis
alternative_term: Postinfectious polyneuritis
alternative_term: acute infective polyneuritis
alternative_term: acute inflammatory demyelinating polyradiculopathy
alternative_term: acute postinfectious polyneuropathy
has_obo_namespace: disease_ontology
id: DOID:12842
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

autistic disorder
type: Class
subclass of: autism spectrum disorder
textual definition: An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.
imported from: doid.owl
has cross-reference: EFO:0003758
has cross-reference: ICD10CM:F84.0
has cross-reference: ICD9CM:299.0
has cross-reference: MESH:D001321
has cross-reference: NCI:C97161
has cross-reference: OMIM:209850
has cross-reference: ORDO:106
has cross-reference: SNOMEDCT_US_2020_03_01:38763009
has cross-reference: UMLS_CUI:C0004352
alternative_term: Kanner's syndrome
alternative_term: autism
alternative_term: autistic disorder of childhood onset
alternative_term: childhood autism
alternative_term: infantile autism
has_obo_namespace: disease_ontology
id: DOID:12849
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

rectal disease
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: MESH:D012002
has cross-reference: SNOMEDCT_US_2020_03_01:5964004
has cross-reference: UMLS_CUI:C0034882
has_obo_namespace: disease_ontology
id: DOID:1285

Huntington's disease
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.
imported from: doid.owl
has cross-reference: GARD:6677
has cross-reference: ICD10CM:G10
has cross-reference: ICD9CM:333.4
has cross-reference: KEGG:05016
has cross-reference: MESH:D006816
has cross-reference: NCI:C82342
has cross-reference: OMIM:143100
has cross-reference: SNOMEDCT_US_2020_03_01:155006000
has cross-reference: UMLS_CUI:C0020179
alternative_term: HD
alternative_term: Huntington disease
alternative_term: Huntington's chorea
has_obo_namespace: disease_ontology
id: DOID:12858
in subset: DO FlyBase slim
in subset: NCIthesaurus

cardiovascular system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
imported from: doid.owl
has_alternative_id: DOID:73
has cross-reference: ICD9CM:429.2
has cross-reference: MESH:D002318
has cross-reference: NCI:C2931
has cross-reference: SNOMEDCT_US_2020_03_01:266275004
has cross-reference: UMLS_CUI:C0007222
alternative_term: disease of subdivision of hemolymphoid system
has_obo_namespace: disease_ontology
id: DOID:1287
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

Miller Fisher syndrome
type: Class
subclass of: Guillain-Barre syndrome
textual definition: A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia.
imported from: doid.owl
has cross-reference: GARD:3668
has cross-reference: ICD10CM:G61.0
has cross-reference: MESH:D019846
has cross-reference: NCI:C116958
has cross-reference: SNOMEDCT_US_2020_03_01:1767005
has cross-reference: UMLS_CUI:C0393799
alternative_term: Fisher's syndrome
alternative_term: Miller-Fisher variant of Guillain-Barre syndrome
has_obo_namespace: disease_ontology
id: DOID:12889
in subset: NCIthesaurus

neurodegenerative disease
type: Class
subclass of: central nervous system disease
textual definition: A central nervous system disease that results in the progressive deterioration of function or structure of neurons.
imported from: doid.owl
has_alternative_id: DOID:4874
has cross-reference: ICD10CM:G31.9
has cross-reference: MESH:D019636
has cross-reference: NCI:C27090
has cross-reference: SNOMEDCT_US_2020_03_01:362975008
has cross-reference: UMLS_CUI:C0524851
has cross-reference: UMLS_CUI:C1285162
alternative_term: Neurodegenerative disease
alternative_term: degenerative disease
has_obo_namespace: disease_ontology
id: DOID:1289
in subset: DO FlyBase slim
in subset: NCIthesaurus

Sjogren's syndrome
type: Class
subclass of: autoimmune disease of exocrine system
textual definition: An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.
imported from: doid.owl
has_alternative_id: DOID:416
has cross-reference: GARD:10252
has cross-reference: ICD10CM:M35.0
has cross-reference: ICD10CM:M35.00
has cross-reference: ICD9CM:710.2
has cross-reference: MESH:D012859
has cross-reference: NCI:C26883
has cross-reference: NCI:C70647
has cross-reference: OMIM:270150
has cross-reference: SNOMEDCT_US_2020_03_01:267875002
has cross-reference: SNOMEDCT_US_2020_03_01:83901003
has cross-reference: UMLS_CUI:C0086981
has cross-reference: UMLS_CUI:C1527336
alternative_term: Sicca syndrome
alternative_term: Sjogren syndrome
alternative_term: xerodermosteosis
has_obo_namespace: disease_ontology
id: DOID:12894
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

keratoconjunctivitis sicca
type: Class
subclass of: dry eye syndrome
imported from: doid.owl
has cross-reference: GARD:8444
has cross-reference: MESH:D007638
has cross-reference: SNOMEDCT_US_2020_03_01:78946008
has cross-reference: UMLS_CUI:C0022575
alternative_term: KCS
has_obo_namespace: disease_ontology
id: DOID:12895

Mikulicz disease
type: Class
subclass of: autoimmune disease
textual definition: An autoimmune disease that is characterized by chronic enlargement of the glands of the head and neck, has_symptom lumps of the face and neck, dry eyes, dry mouth, and intermittent fever, and is often associated with an underlying autoimmune disorder, hematologic malignancy, tuberculosis infection, or syphilis infection.
imported from: doid.owl
has cross-reference: GARD:7043
has cross-reference: ICD10CM:K11.8
has cross-reference: MESH:D008882
has cross-reference: NCI:C34819
has cross-reference: SNOMEDCT_US_2020_03_01:7826003
has cross-reference: UMLS_CUI:C0026103
alternative_term: IgG4-related dacryoadenitis and sialadenitis
alternative_term: Mikulicz's disease
has_obo_namespace: disease_ontology
id: DOID:12900
in subset: NCIthesaurus

necrotizing sialometaplasia
type: Class
subclass of: salivary gland disease
imported from: doid.owl
has cross-reference: ICD10CM:K11.8
has cross-reference: MESH:D012797
has cross-reference: SNOMEDCT_US_2020_03_01:109769000
has cross-reference: UMLS_CUI:C0037033
alternative_term: Necrotizing sialometaplasia
has_obo_namespace: disease_ontology
id: DOID:12901

mucocele of salivary gland
type: Class
subclass of: salivary gland disease
imported from: doid.owl
has cross-reference: ICD10CM:K11.6
has cross-reference: ICD9CM:527.6
has cross-reference: NCI:C27649
has cross-reference: SNOMEDCT_US_2020_03_01:196508008
has cross-reference: UMLS_CUI:C0026686
alternative_term: Mucous retention cyst of salivary gland
alternative_term: Ranula
alternative_term: Salivary Cyst
alternative_term: Salivary gland mucocele
has_obo_namespace: disease_ontology
id: DOID:12904
in subset: NCIthesaurus

endocardial fibroelastosis
type: Class
subclass of: endocardium disease
textual definition: An endocardium disease that is characterized by a thickening of the inmost lining of the heart chambers due to an increase in the amount of supporting connective tissue and elastic fibers.
imported from: doid.owl
has cross-reference: GARD:2121
has cross-reference: GARD:6336
has cross-reference: ICD10CM:I42.4
has cross-reference: ICD9CM:425.3
has cross-reference: MESH:D004695
has cross-reference: NCI:C98922
has cross-reference: OMIM:226000
has cross-reference: SNOMEDCT_US_2020_03_01:65457005
has cross-reference: UMLS_CUI:C0014117
alternative_term: Elastomyofibrosis
has_obo_namespace: disease_ontology
id: DOID:12929
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

dilated cardiomyopathy
type: Class
subclass of: intrinsic cardiomyopathy
textual definition: An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.
imported from: doid.owl
has cross-reference: EFO:0000407
has cross-reference: GARD:221
has cross-reference: ICD10CM:I42.0
has cross-reference: KEGG:05414
has cross-reference: MESH:D002311
has cross-reference: NCI:C84673
has cross-reference: OMIM:PS115200
has cross-reference: ORDO:217604
has cross-reference: SNOMEDCT_US_2020_03_01:74368002
has cross-reference: UMLS_CUI:C0007193
alternative_term: primary dilated cardiomyopathy
has_obo_namespace: disease_ontology
has_related_synonym: Congestive cardiomyopathy
has_related_synonym: Familial dilated cardiomyopathy
has_related_synonym: Idiopathic dilation cardiomyopathy
id: DOID:12930
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [LS].

endomyocardial fibrosis
type: Class
subclass of: restrictive cardiomyopathy
imported from: doid.owl
has cross-reference: GARD:6340
has cross-reference: ICD9CM:425.0
has cross-reference: MESH:D004719
has cross-reference: NCI:C34585
has cross-reference: SNOMEDCT_US_2020_03_01:111507009
has cross-reference: UMLS_CUI:C0553980
alternative_term: African endomyocardial fibrosis
alternative_term: Becker's disease
alternative_term: Endomyocardial sclerosis
alternative_term: Obscure African cardiomyopathy
alternative_term: obscure African cardiomyopathy
has_obo_namespace: disease_ontology
id: DOID:12932
in subset: NCIthesaurus

Kearns-Sayre syndrome
type: Class
subclass of: chronic progressive external ophthalmoplegia
imported from: doid.owl
has cross-reference: GARD:6817
has cross-reference: ICD10CM:H49.81
has cross-reference: MESH:D007625
has cross-reference: NCI:C84798
has cross-reference: OMIM:530000
has cross-reference: SNOMEDCT_US_2020_03_01:25792000
has cross-reference: UMLS_CUI:C0022541
has_obo_namespace: disease_ontology
id: DOID:12934
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

vulva carcinoma
type: Class
subclass of: vulva cancer
subclass of: carcinoma
textual definition: A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C4866
has cross-reference: UMLS_CUI:C0677055
alternative_term: Vulvar carcinoma
has_obo_namespace: disease_ontology
has_related_synonym: carcinoma of vulva
id: DOID:1294
in subset: NCIthesaurus

lagophthalmos
type: Class
subclass of: eyelid disease
imported from: doid.owl
has cross-reference: ICD10CM:H02.2
has cross-reference: ICD9CM:374.2
has cross-reference: SNOMEDCT_US_2020_03_01:193936001
has cross-reference: UMLS_CUI:C0152226
has_obo_namespace: disease_ontology
id: DOID:12959

acrocephalosyndactylia
type: Class
subclass of: synostosis
textual definition: A synostosis that results_in craniosynostosis and syndactyly.
imported from: doid.owl
has_alternative_id: DOID:0080004
has cross-reference: ICD9CM:755.55
has cross-reference: MESH:D000168
has cross-reference: NCI:C34348
has cross-reference: OMIM:101200
has cross-reference: SNOMEDCT_US_2020_03_01:63661009
has cross-reference: UMLS_CUI:C1510455
alternative_term: Apert syndrome
has_obo_namespace: disease_ontology
id: DOID:12960
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

central nervous system leukemia
type: Class
subclass of: central nervous system cancer
textual definition: A hematologic cancer located_in the central nervous system.
imported from: doid.owl
has cross-reference: NCI:C5440
has cross-reference: UMLS_CUI:C1332884
alternative_term: Leukemia of the CNS
has_obo_namespace: disease_ontology
id: DOID:12969
in subset: NCIthesaurus

hereditary spherocytosis
type: Class
subclass of: congenital hemolytic anemia
textual definition: A congenital hemolytic anemia characterized by the production of red blood cells with a sphere shape, rather than the normal biconcave disk shape.
imported from: doid.owl
has cross-reference: GARD:6639
has cross-reference: ICD10CM:D58.0
has cross-reference: ICD9CM:282.0
has cross-reference: MESH:D013103
has cross-reference: NCI:C97074
has cross-reference: ORDO:822
has cross-reference: SNOMEDCT_US_2020_03_01:154795009
has cross-reference: UMLS_CUI:C0037889
alternative_term: Congenital spherocytic hemolytic anemia
alternative_term: Minkowski Chauffard syndrome
alternative_term: spherocytic anemia
has_obo_namespace: disease_ontology
id: DOID:12971
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

leukostasis
type: Class
subclass of: DOID 9500
imported from: doid.owl
has cross-reference: MESH:D018921
has cross-reference: NCI:C4062
has cross-reference: SNOMEDCT_US_2020_03_01:30419000
has cross-reference: UMLS_CUI:C0282548
alternative_term: Leukostasis
has_obo_namespace: disease_ontology
id: DOID:12986
in subset: NCIthesaurus

agranulocytosis
type: Class
subclass of: leukopenia
textual definition: A leukopenia that is characterized by a severe lack of of granulocytes with a drop in granulocyte concentration below 200 cells/mm³ of blood.
imported from: doid.owl
has cross-reference: ICD10CM:D70
has cross-reference: MESH:D000380
has cross-reference: SNOMEDCT_US_2020_03_01:154830007
has cross-reference: UMLS_CUI:C0001824
alternative_term: Granulocytopenic disorder
alternative_term: Granulopenia
alternative_term: granulocytopenia
has_obo_namespace: disease_ontology
id: DOID:12987
in subset: NCIthesaurus

conduct disorder
type: Class
subclass of: specific developmental disorder
textual definition: A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.
imported from: doid.owl
has cross-reference: EFO:0004216
has cross-reference: ICD10CM:F91
has cross-reference: ICD9CM:312.9
has cross-reference: MESH:D019955
has cross-reference: NCI:C89329
has cross-reference: SNOMEDCT_US_2020_03_01:430909002
has cross-reference: UMLS_CUI:C0149654
has_obo_namespace: disease_ontology
id: DOID:12995
in subset: NCIthesaurus

carotid stenosis
type: Class
subclass of: carotid artery disease
imported from: doid.owl
has cross-reference: MESH:D016893
has cross-reference: NCI:C95804
has cross-reference: SNOMEDCT_US_2020_03_01:195181000
has cross-reference: UMLS_CUI:C0007282
alternative_term: Carotid artery stenosis
alternative_term: Stenosis, carotid artery
has_obo_namespace: disease_ontology
id: DOID:13001
in subset: NCIthesaurus

subclavian steal syndrome
type: Class
subclass of: syndrome
imported from: doid.owl
has cross-reference: ICD9CM:435.2
has cross-reference: MESH:D013349
has cross-reference: NCI:C35044
has cross-reference: SNOMEDCT_US_2020_03_01:15258001
has cross-reference: UMLS_CUI:C0038531
alternative_term: Subclavian artery stenosis
alternative_term: subclavian steal phenomenon
alternative_term: subclavian steal steno-occlusive disease
has_obo_namespace: disease_ontology
id: DOID:13002
in subset: NCIthesaurus

vertebrobasilar insufficiency
type: Class
subclass of: transient cerebral ischemia
imported from: doid.owl
has cross-reference: ICD10CM:G45.0
has cross-reference: ICD9CM:435.3
has cross-reference: MESH:D014715
has cross-reference: SNOMEDCT_US_2020_03_01:195196001
has cross-reference: UMLS_CUI:C0042568
alternative_term: Vertebro-basilar insufficiency
alternative_term: Vertebrobasilar arterial insufficiency
alternative_term: Vertebrobasilar artery syndrome
alternative_term: Vertebrobasilar insufficiency
has_obo_namespace: disease_ontology
id: DOID:13003

shipyard eye
type: Class
subclass of: DOID 9368
imported from: doid.owl
has cross-reference: ICD10CM:B30.0
has cross-reference: ICD9CM:077.1
has cross-reference: NCI:C34590
has cross-reference: SNOMEDCT_US_2020_03_01:60548004
has cross-reference: UMLS_CUI:C0014493
alternative_term: EKC
alternative_term: Epidemic keratoconjunctivitis
has_obo_namespace: disease_ontology
id: DOID:13014
in subset: NCIthesaurus

retinopathy of prematurity
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: GARD:5695
has cross-reference: ICD10CM:H35.1
has cross-reference: ICD9CM:362.21
has cross-reference: MESH:D012178
has cross-reference: NCI:C34982
has cross-reference: SNOMEDCT_US_2020_03_01:155110004
has cross-reference: UMLS_CUI:C0035344
alternative_term: Retrolental fibroplasia
alternative_term: premature retinopathy
has_obo_namespace: disease_ontology
id: DOID:13025
in subset: NCIthesaurus

transient global amnesia
type: Class
subclass of: amnestic disorder
textual definition: An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.
imported from: doid.owl
has cross-reference: GARD:8172
has cross-reference: ICD10CM:G45.4
has cross-reference: ICD9CM:437.7
has cross-reference: MESH:D020236
has cross-reference: NCI:C85198
has cross-reference: SNOMEDCT_US_2020_03_01:366963000
has cross-reference: UMLS_CUI:C0338591
has_obo_namespace: disease_ontology
id: DOID:13027
in subset: NCIthesaurus

balanitis
type: Class
subclass of: penile disease
imported from: doid.owl
has cross-reference: ICD10CM:N48.1
has cross-reference: MESH:D001446
has cross-reference: NCI:C26705
has cross-reference: SNOMEDCT_US_2020_03_01:155928003
has cross-reference: UMLS_CUI:C0004690
has_obo_namespace: disease_ontology
id: DOID:13033
in subset: NCIthesaurus

relapsing fever
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse.
imported from: doid.owl
has cross-reference: ICD10CM:A68
has cross-reference: ICD9CM:087
has cross-reference: MESH:D012061
has cross-reference: SNOMEDCT_US_2020_03_01:186820006
has cross-reference: UMLS_CUI:C0035021
has_obo_namespace: disease_ontology
id: DOID:13034
in subset: gram-negative bacterial infectious disease

tick-borne relapsing fever
type: Class
subclass of: relapsing fever
textual definition: A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.
imported from: doid.owl
has cross-reference: ICD10CM:A68.1
has cross-reference: ICD9CM:087.1
has cross-reference: NCI:C34976
has cross-reference: SNOMEDCT_US_2020_03_01:10301003
has cross-reference: UMLS_CUI:C0035022
alternative_term: Relapsing fever, tick-borne
alternative_term: Tick-borne relapsing fever
has_obo_namespace: disease_ontology
id: DOID:13036
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

persistent fetal circulation syndrome
type: Class
subclass of: pulmonary hypertension
imported from: doid.owl
has cross-reference: ICD10CM:P29.3
has cross-reference: ICD9CM:747.83
has cross-reference: MESH:D010547
has cross-reference: NCI:C85006
has cross-reference: OMIM:265380
has cross-reference: SNOMEDCT_US_2020_03_01:35604006
has cross-reference: UMLS_CUI:C0031190
alternative_term: Fetal circulation
alternative_term: Persistent fetal circulation
alternative_term: Persistent fetal circulation syndrome
alternative_term: Persistent foetal circulation
alternative_term: Persistent foetal circulation syndrome
alternative_term: Persistent pulmonary hypertension of the newborn
alternative_term: congenital alveolar capillary dysplasia with misalignment of pulmonary veins
alternative_term: persistent foetal circulation syndrome
alternative_term: persistent pulmonary hypertension of the newborn
has_obo_namespace: disease_ontology
id: DOID:13042
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

renal osteodystrophy
type: Class
subclass of: kidney disease
imported from: doid.owl
has cross-reference: ICD10CM:N25.0
has cross-reference: ICD9CM:588.0
has cross-reference: MESH:D012080
has cross-reference: NCI:C114827
has cross-reference: SNOMEDCT_US_2020_03_01:266617009
has cross-reference: UMLS_CUI:C0035086
alternative_term: renal rickets
has_obo_namespace: disease_ontology
id: DOID:13068
in subset: NCIthesaurus

dementia
type: Class
subclass of: cognitive disorder
textual definition: A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.
imported from: doid.owl
has cross-reference: ICD9CM:290.8
has cross-reference: UMLS_CUI:C0154319
has_obo_namespace: disease_ontology
id: DOID:1307

tinea unguium
type: Class
subclass of: nail disease
subclass of: DOID 8913
textual definition: A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.
imported from: doid.owl
has_alternative_id: DOID:10462
has_alternative_id: DOID:11399
has_alternative_id: DOID:11761
has_alternative_id: DOID:12844
has_alternative_id: DOID:12845
has_alternative_id: DOID:12846
has_alternative_id: DOID:12847
has_alternative_id: DOID:12848
has_alternative_id: DOID:13119
has_alternative_id: DOID:9412
has_alternative_id: DOID:9690
has_alternative_id: DOID:9691
has cross-reference: ICD9CM:681.9
has cross-reference: UMLS_CUI:C0007644
alternative_term: Dermatophytic onychia
alternative_term: Dermatophytosis of nail
alternative_term: Onychomycosis due to dermatophyte
alternative_term: cellulitis and abscess of buttock
alternative_term: cellulitis and abscess of face
alternative_term: cellulitis and abscess of finger
alternative_term: cellulitis and abscess of finger and toe
alternative_term: cellulitis and abscess of gluteal region
alternative_term: cellulitis and abscess of trunk
alternative_term: cellulitis and abscess of upper arm and forearm
alternative_term: dermatophytic onychomycosis
has_obo_namespace: disease_ontology
has_related_synonym: Tinea unguium
has_related_synonym: cellulitis and abscess
id: DOID:13074

eumycotic mycetoma
type: Class
subclass of: dermatomycosis
textual definition: A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules.
imported from: doid.owl
has cross-reference: ICD10CM:B47
has cross-reference: MESH:D008271
has cross-reference: NCI:C85505
has cross-reference: SNOMEDCT_US_2020_03_01:410039003
has cross-reference: UMLS_CUI:C0024449
alternative_term: Madura foot
alternative_term: Maduromycosis, mycotic
alternative_term: Mycotic mycetoma
alternative_term: eumycetoma
alternative_term: maduromycosis
has_obo_namespace: disease_ontology
id: DOID:13078
in subset: NCIthesaurus

periventricular leukomalacia
type: Class
subclass of: encephalomalacia
imported from: doid.owl
has cross-reference: GARD:10285
has cross-reference: ICD10CM:P91.2
has cross-reference: ICD9CM:779.7
has cross-reference: MESH:D007969
has cross-reference: NCI:C99013
has cross-reference: SNOMEDCT_US_2020_03_01:230769007
has cross-reference: UMLS_CUI:C0023529
has_obo_namespace: disease_ontology
id: DOID:13088
in subset: NCIthesaurus

intracranial arterial disease
type: Class
subclass of: cerebrovascular disease
imported from: doid.owl
has cross-reference: MESH:D020765
has cross-reference: UMLS_CUI:C0752138
has_obo_namespace: disease_ontology
id: DOID:13089

branch retinal artery occlusion
type: Class
subclass of: retinal artery occlusion
imported from: doid.owl
has cross-reference: ICD10CM:H34.23
has cross-reference: ICD9CM:362.32
has cross-reference: MESH:D015356
has cross-reference: NCI:C34436
has cross-reference: SNOMEDCT_US_2020_03_01:50821009
has cross-reference: UMLS_CUI:C0006123
alternative_term: Arterial retinal branch occlusion
alternative_term: Retinal Arterial Branch Occlusion
alternative_term: Retinal arterial branch occlusion
has_obo_namespace: disease_ontology
id: DOID:13094
in subset: NCIthesaurus

vertebral artery insufficiency
type: Class
subclass of: artery disease
subclass of: transient cerebral ischemia
subclass of: syndrome
imported from: doid.owl
has cross-reference: MESH:D014715
has cross-reference: UMLS_CUI:C0042560
alternative_term: Vertebral artery syndrome
has_obo_namespace: disease_ontology
id: DOID:13095

central retinal artery occlusion
type: Class
subclass of: retinal artery occlusion
textual definition: A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.
imported from: doid.owl
has cross-reference: ICD10CM:H34.1
has cross-reference: ICD9CM:362.31
has cross-reference: MESH:D015356
has cross-reference: NCI:C34456
has cross-reference: SNOMEDCT_US_2020_03_01:38742007
has cross-reference: UMLS_CUI:C0007688
has_obo_namespace: disease_ontology
id: DOID:13098
in subset: NCIthesaurus

Moyamoya disease
type: Class
subclass of: cerebral arterial disease
textual definition: A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.
imported from: doid.owl
has cross-reference: GARD:7064
has cross-reference: ICD10CM:I67.5
has cross-reference: ICD9CM:437.5
has cross-reference: MESH:D009072
has cross-reference: NCI:C84895
has cross-reference: OMIM:252350
has cross-reference: OMIM:300845
has cross-reference: OMIM:607151
has cross-reference: OMIM:608796
has cross-reference: OMIM:614042
has cross-reference: OMIM:615750
has cross-reference: ORDO:2573
has cross-reference: ORDO:280679
has cross-reference: ORDO:401945
has cross-reference: SNOMEDCT_US_2020_03_01:69116000
has cross-reference: UMLS_CUI:C0026654
alternative_term: progressive intracranial arterial occlusion
has_obo_namespace: disease_ontology
id: DOID:13099
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

intracranial vasospasm
type: Class
subclass of: cerebrovascular disease
imported from: doid.owl
has cross-reference: MESH:D020301
has cross-reference: UMLS_CUI:C0751895
has_obo_namespace: disease_ontology
id: DOID:13100

bladder leiomyoma
type: Class
subclass of: bladder benign neoplasm
subclass of: leiomyoma
textual definition: A bladder benign neoplasm that derives_from smooth muscle cells.
imported from: doid.owl
has cross-reference: NCI:C6178
has cross-reference: UMLS_CUI:C1332560
alternative_term: leiomyoma of the urinary bladder
has_obo_namespace: disease_ontology
id: DOID:13109
in subset: NCIthesaurus

cicatricial entropion
type: Class
subclass of: entropion
imported from: doid.owl
has cross-reference: ICD9CM:374.04
has cross-reference: SNOMEDCT_US_2020_03_01:67383002
has cross-reference: UMLS_CUI:C0155191
has_obo_namespace: disease_ontology
id: DOID:13113

focal segmental glomerulosclerosis
type: Class
subclass of: glomerulosclerosis
imported from: doid.owl
has_alternative_id: DOID:3945
has cross-reference: EFO:0004236
has cross-reference: GARD:6517
has cross-reference: MESH:D005923
has cross-reference: NCI:C37308
has cross-reference: OMIM:PS603278
has cross-reference: SNOMEDCT_US_2020_03_01:25821008
has cross-reference: UMLS_CUI:C0017668
alternative_term: FGS
alternative_term: FSGS
alternative_term: focal glomerular sclerosis
alternative_term: focal glomerulosclerosis
has_obo_namespace: disease_ontology
id: DOID:1312
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

protein-deficiency anemia
type: Class
subclass of: deficiency anemia
imported from: doid.owl
has cross-reference: ICD10CM:D53.0
has cross-reference: ICD9CM:281.4
has cross-reference: SNOMEDCT_US_2020_03_01:85746008
has cross-reference: UMLS_CUI:C0154290
alternative_term: Anemia due to protein deficiency
alternative_term: Protein-deficiency anaemia
alternative_term: Protein-deficiency anemia
alternative_term: protein-deficiency anaemia
has_obo_namespace: disease_ontology
id: DOID:13120

deficiency anemia
type: Class
subclass of: anemia
imported from: doid.owl
has cross-reference: ICD9CM:281.9
has cross-reference: SNOMEDCT_US_2020_03_01:191125001
has cross-reference: UMLS_CUI:C0041782
alternative_term: deficiency anemias
has_obo_namespace: disease_ontology
id: DOID:13121

Werdnig-Hoffmann disease
type: Class
subclass of: childhood spinal muscular atrophy
textual definition: A childhood spinal muscular atrophy that is a severe form and is characterized by muscle weakness onset from birth to six months of age, the inability to sit unassisted.
imported from: doid.owl
has cross-reference: GARD:7883
has cross-reference: ICD10CM:G12.0
has cross-reference: ICD9CM:335.0
has cross-reference: MESH:D014897
has cross-reference: NCI:C98670
has cross-reference: OMIM:253300
has cross-reference: SNOMEDCT_US_2020_03_01:64383006
has cross-reference: UMLS_CUI:C0043116
alternative_term: HMN (Hereditary motor Neuropathy) Proximal type I
alternative_term: SMA1
alternative_term: Spinal muscular atrophy 1
alternative_term: hereditary motor neuropathy proximal type I
alternative_term: infantile muscular atrophy
alternative_term: progressive muscular atrophy of infancy
has_obo_namespace: disease_ontology
id: DOID:13137
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

acute proliferative glomerulonephritis
type: Class
subclass of: glomerulonephritis
imported from: doid.owl
has cross-reference: ICD9CM:580.0
has cross-reference: SNOMEDCT_US_2020_03_01:197579006
has cross-reference: UMLS_CUI:C0341692
alternative_term: acute glomerulonephritis with lesion of proliferative glomerulonephritis
has_obo_namespace: disease_ontology
id: DOID:13138

crescentic glomerulonephritis
type: Class
subclass of: acute proliferative glomerulonephritis
imported from: doid.owl
has cross-reference: NCI:C128143
has cross-reference: SNOMEDCT_US_2020_03_01:45406000
has cross-reference: UMLS_CUI:C0403416
has_obo_namespace: disease_ontology
id: DOID:13139
in subset: NCIthesaurus

uveitis
type: Class
subclass of: uveal disease
textual definition: An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid.
imported from: doid.owl
has cross-reference: ICD10CM:H20.9
has cross-reference: MESH:D014605
has cross-reference: NCI:C26909
has cross-reference: SNOMEDCT_US_2020_03_01:267719008
has cross-reference: UMLS_CUI:C0042164
has_obo_namespace: disease_ontology
id: DOID:13141
in subset: NCIthesaurus

dissociated nystagmus
type: Class
subclass of: DOID 9650
imported from: doid.owl
has cross-reference: ICD10CM:H55.04
has cross-reference: ICD9CM:379.55
has cross-reference: MESH:D009759
has cross-reference: SNOMEDCT_US_2020_03_01:9520006
has cross-reference: UMLS_CUI:C0155380
alternative_term: Dissociated nystagmus
has_obo_namespace: disease_ontology
id: DOID:13174

gout
type: Class
subclass of: arthritis
textual definition: An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.
imported from: doid.owl
has_alternative_id: DOID:14144
has cross-reference: EFO:0004274
has cross-reference: ICD10CM:M10
has cross-reference: ICD9CM:274
has cross-reference: ICD9CM:274.0
has cross-reference: MESH:D006073
has cross-reference: MESH:D015210
has cross-reference: NCI:C34650
has cross-reference: SNOMEDCT_US_2020_03_01:201661008
has cross-reference: SNOMEDCT_US_2020_03_01:90560007
has cross-reference: UMLS_CUI:C0003868
has cross-reference: UMLS_CUI:C0018099
alternative_term: Articular gout
alternative_term: Gouty arthropathy
alternative_term: gouty arthritis
has_obo_namespace: disease_ontology
id: DOID:13189
in subset: NCIthesaurus

brain cancer
type: Class
subclass of: central nervous system cancer
subclass of: DOID 936
textual definition: A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain.
imported from: doid.owl
has_alternative_id: DOID:2125
has_alternative_id: DOID:2126
has_alternative_id: DOID:3543
has_alternative_id: DOID:6649
has_alternative_id: DOID:911
has cross-reference: ICD10CM:C71
has cross-reference: ICD9CM:191
has cross-reference: ICD9CM:239.6
has cross-reference: MESH:D001932
has cross-reference: NCI:C2907
has cross-reference: NCI:C3568
has cross-reference: NCI:C5115
has cross-reference: NCI:C7710
has cross-reference: SNOMEDCT_US_2020_03_01:126952004
has cross-reference: SNOMEDCT_US_2020_03_01:428061005
has cross-reference: SNOMEDCT_US_2020_03_01:93727008
has cross-reference: UMLS_CUI:C0006118
has cross-reference: UMLS_CUI:C0153633
has cross-reference: UMLS_CUI:C0220624
has cross-reference: UMLS_CUI:C0750974
has cross-reference: UMLS_CUI:C0750979
has cross-reference: UMLS_CUI:C1334557
alternative_term: BT - Brain tumour
alternative_term: adult brain tumor
alternative_term: adult malignant brain neoplasm
alternative_term: brain neoplasm
alternative_term: brain neoplasm, adult
alternative_term: malignant brain tumour
alternative_term: malignant primary brain neoplasm
alternative_term: malignant primary brain tumor
alternative_term: malignant tumor of Brain
alternative_term: malignant tumor of adult brain
alternative_term: neoplasm of brain
alternative_term: primary brain neoplasm
alternative_term: primary brain tumor
alternative_term: primary malignant neoplasm of brain
alternative_term: tumor of the Brain
has_obo_namespace: disease_ontology
id: DOID:1319
in subset: DO FlyBase slim
in subset: DO cancer slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

substernal goiter
type: Class
subclass of: goiter
imported from: doid.owl
has cross-reference: MESH:D006045
has cross-reference: SNOMEDCT_US_2020_03_01:66392007
has cross-reference: UMLS_CUI:C0018024
alternative_term: Retrosternal thyroid goiter
alternative_term: Retrosternal thyroid goitre
alternative_term: Substernal goiter
alternative_term: Substernal goitre
alternative_term: substernal goitre
has_obo_namespace: disease_ontology
id: DOID:13200

proliferative diabetic retinopathy
type: Class
subclass of: DOID 8947
imported from: doid.owl
has cross-reference: ICD9CM:362.02
has cross-reference: NCI:C84457
has cross-reference: SNOMEDCT_US_2020_03_01:154679002
has cross-reference: UMLS_CUI:C0154830
alternative_term: PDR
has_obo_namespace: disease_ontology
id: DOID:13207
in subset: NCIthesaurus

right bundle branch block
type: Class
subclass of: heart conduction disease
imported from: doid.owl
has cross-reference: ICD9CM:426.51
has cross-reference: SNOMEDCT_US_2020_03_01:46319007
has cross-reference: UMLS_CUI:C0155704
alternative_term: Right bundle branch block with left posterior fascicular block
has_obo_namespace: disease_ontology
id: DOID:13209

uterine fibroid
type: Class
subclass of: uterine benign neoplasm
textual definition: An uterine benign neoplasm derived from the smooth muscle layer of the uterus.
imported from: doid.owl
has cross-reference: EFO:0000731
has cross-reference: ICD10CM:D25
has cross-reference: ICD9CM:218
has cross-reference: MESH:D007889
has cross-reference: NCI:C3434
has cross-reference: OMIM:150699
has cross-reference: SNOMEDCT_US_2020_03_01:95315005
has cross-reference: UMLS_CUI:C0042133
alternative_term: Plexiform leiomyoma
alternative_term: UTERUS FIBROMA
alternative_term: leiomyoma of Corpus Uteri
alternative_term: uterine leiomyoma
has_obo_namespace: disease_ontology
id: DOID:13223
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

lung cancer
type: Class
subclass of: respiratory system cancer
subclass of: lung disease
textual definition: A respiratory system cancer that is located_in the lung.
imported from: doid.owl
has_alternative_id: DOID:13075
has_alternative_id: DOID:1322
has_alternative_id: DOID:9881
has cross-reference: ICD10CM:C34.1
has cross-reference: ICD10CM:C34.2
has cross-reference: ICD10CM:C34.3
has cross-reference: ICD9CM:162.3
has cross-reference: ICD9CM:162.4
has cross-reference: ICD9CM:162.5
has cross-reference: ICD9CM:162.8
has cross-reference: OMIM:211980
has cross-reference: OMIM:608935
has cross-reference: OMIM:612571
has cross-reference: OMIM:612593
has cross-reference: OMIM:614210
has cross-reference: SNOMEDCT_US_2020_03_01:187860004
has cross-reference: SNOMEDCT_US_2020_03_01:187864008
has cross-reference: SNOMEDCT_US_2020_03_01:187868006
has cross-reference: SNOMEDCT_US_2020_03_01:187874006
has cross-reference: UMLS_CUI:C0024624
has cross-reference: UMLS_CUI:C0153491
has cross-reference: UMLS_CUI:C0153492
has cross-reference: UMLS_CUI:C0153493
has_obo_namespace: disease_ontology
has_related_synonym: lung neoplasm
id: DOID:1324
in subset: TopNodes DOcancerslim

tooth resorption
type: Class
subclass of: teeth hard tissue disease
imported from: doid.owl
has cross-reference: ICD10CM:K03.3
has cross-reference: ICD9CM:521.4
has cross-reference: MESH:D014091
has cross-reference: SNOMEDCT_US_2020_03_01:70931000
has cross-reference: UMLS_CUI:C0040451
has_obo_namespace: disease_ontology
id: DOID:13240

bronchus cancer
type: Class
subclass of: respiratory system cancer
subclass of: bronchial disease
textual definition: A respiratory system cancer that is located_in the bronchus.
imported from: doid.owl
has cross-reference: ICD10CM:C34
has cross-reference: ICD9CM:162.9
has cross-reference: SNOMEDCT_US_2020_03_01:187875007
has cross-reference: UMLS_CUI:C0348343
alternative_term: malignant neoplasm of bronchus and lung
alternative_term: malignant neoplasm of bronchus or lung
has_obo_namespace: disease_ontology
id: DOID:1325

diarrhea
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.
imported from: doid.owl
has_alternative_id: DOID:0050006
has cross-reference: ICD9CM:009.2
has cross-reference: MESH:D004403
has cross-reference: SNOMEDCT_US_2020_03_01:154268000
has cross-reference: UMLS_CUI:C0013369
has_obo_namespace: disease_ontology
has_related_synonym: diarrhea of presumed infectious origin
has_related_synonym: diarrhoea
id: DOID:13250
in subset: GOLD
comment: diarrhea is both a disease and a symptom [ms]

typhoid fever
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.
imported from: doid.owl
has_alternative_id: DOID:3054
has cross-reference: GARD:9564
has cross-reference: ICD10CM:A01.0
has cross-reference: ICD9CM:002.0
has cross-reference: MESH:D014435
has cross-reference: NCI:C35089
has cross-reference: SNOMEDCT_US_2020_03_01:186091002
has cross-reference: UMLS_CUI:C0041466
alternative_term: Typhoid
has_obo_namespace: disease_ontology
id: DOID:13258
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease

porphyria
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins.
imported from: doid.owl
has cross-reference: GARD:10353
has cross-reference: ICD10CM:E80.20
has cross-reference: ICD9CM:277.1
has cross-reference: MESH:D011164
has cross-reference: NCI:C97096
has cross-reference: SNOMEDCT_US_2020_03_01:190912004
has cross-reference: UMLS_CUI:C0032708
alternative_term: Hematoporphyria
alternative_term: Porphyrinopathy
alternative_term: disorder of porphyrin and hem metabolism
alternative_term: disorder of porphyrin metabolism
has_obo_namespace: disease_ontology
id: DOID:13268
in subset: NCIthesaurus

hereditary coproporphyria
type: Class
subclass of: acute porphyria
imported from: doid.owl
has cross-reference: GARD:6619
has cross-reference: ICD10CM:E80.29
has cross-reference: MESH:D046349
has cross-reference: NCI:C84759
has cross-reference: OMIM:121300
has cross-reference: SNOMEDCT_US_2020_03_01:7425008
has cross-reference: UMLS_CUI:C0162531
alternative_term: Coproporphyrinogen oxidase deficiency
alternative_term: Hereditary coproporphyria
alternative_term: hereditary coproporphyria porphyria
has_obo_namespace: disease_ontology
id: DOID:13269
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

erythropoietic protoporphyria
type: Class
subclass of: acute porphyria
textual definition: An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue.
imported from: doid.owl
has cross-reference: GARD:4527
has cross-reference: ICD10CM:E80.0
has cross-reference: MESH:D046351
has cross-reference: NCI:C84698
has cross-reference: OMIM:177000
has cross-reference: OMIM:300752
has cross-reference: ORDO:79278
has cross-reference: SNOMEDCT_US_2020_03_01:51022005
has cross-reference: UMLS_CUI:C0162568
alternative_term: EPP
alternative_term: Erythropoietic protoporphyria
alternative_term: Protoporphyria
has_obo_namespace: disease_ontology
id: DOID:13270
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

cutaneous porphyria
type: Class
subclass of: porphyria
subclass of: skin disease
imported from: doid.owl
has cross-reference: GARD:4446
has cross-reference: ICD10CM:E80.0
has cross-reference: MESH:D017092
has cross-reference: NCI:C84697
has cross-reference: OMIM:263700
has cross-reference: SNOMEDCT_US_2020_03_01:67312003
has cross-reference: UMLS_CUI:C0162530
alternative_term: Erythropoietic porphyria
has_obo_namespace: disease_ontology
id: DOID:13271
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Rift Valley fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.
imported from: doid.owl
has cross-reference: ICD10CM:A92.4
has cross-reference: MESH:D012295
has cross-reference: NCI:C128419
has cross-reference: SNOMEDCT_US_2020_03_01:7077006
has cross-reference: UMLS_CUI:C0035613
has_obo_namespace: disease_ontology
id: DOID:1328
in subset: NCIthesaurus
in subset: zoonotic infectious disease

intestinal tuberculosis
type: Class
subclass of: gastrointestinal tuberculosis
subclass of: intestinal disease
textual definition: A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.
imported from: doid.owl
has cross-reference: ICD9CM:014.8
has cross-reference: UMLS_CUI:C0152724
alternative_term: tuberculosis of intestine
has_obo_namespace: disease_ontology
id: DOID:13282
in subset: gram-positive bacterial infectious disease

Scheuermann's disease
type: Class
subclass of: spinal disease
subclass of: osteochondrosis
textual definition: An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column.
imported from: doid.owl
has cross-reference: GARD:7610
has cross-reference: ICD10CM:M42.0
has cross-reference: ICD9CM:732.0
has cross-reference: MESH:D012544
has cross-reference: NCI:C34999
has cross-reference: OMIM:181440
has cross-reference: SNOMEDCT_US_2020_03_01:53406005
has cross-reference: UMLS_CUI:C0036310
alternative_term: Juvenile osteochondritis of the spine
alternative_term: Juvenile osteochondrosis of Scheurermann
alternative_term: Juvenile osteochondrosis of spine
alternative_term: Scheuermann's kyphosis
alternative_term: Sherman's Disease
has_narrow_synonym: Scheuermann disease
has_obo_namespace: disease_ontology
id: DOID:13300
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

exocrine pancreatic insufficiency
type: Class
subclass of: pancreas disease
imported from: doid.owl
has cross-reference: ICD10CM:K86.81
has cross-reference: MESH:D010188
has cross-reference: NCI:C84316
has cross-reference: SNOMEDCT_US_2020_03_01:47367009
has cross-reference: UMLS_CUI:C0267963
alternative_term: Exocrine pancreatic insufficiency
has_obo_namespace: disease_ontology
id: DOID:13316
in subset: NCIthesaurus

hyperinsulinemic hypoglycemia
type: Class
subclass of: carbohydrate metabolic disorder
textual definition: A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin.
imported from: doid.owl
has_alternative_id: DOID:9996
has cross-reference: ICD10CM:E16.9
has cross-reference: MESH:D046768
has cross-reference: NCI:C4375
has cross-reference: SNOMEDCT_US_2020_03_01:42681006
has cross-reference: UMLS_CUI:C0027773
alternative_term: Islet cell hyperplasia
alternative_term: nesidioblastosis
alternative_term: persistent hyperinsulinemia hypoglycemia of infancy
has_obo_namespace: disease_ontology
id: DOID:13317
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

diabetic cataract
type: Class
subclass of: cataract
textual definition: A cataract that is characterized by loss of lens transparency secondary to hyperglycemia related to diabetes mellitus.
imported from: doid.owl
has cross-reference: ICD9CM:366.41
has cross-reference: SNOMEDCT_US_2020_03_01:43959009
has cross-reference: UMLS_CUI:C0011876
alternative_term: Cataract - diabetic
has_obo_namespace: disease_ontology
id: DOID:13328

congenital toxoplasmosis
type: Class
subclass of: physical disorder
subclass of: DOID 9965
textual definition: A toxoplasmosis that involves a reactivated infection of the mother transmitted to the fetus during pregnancy. Spontaneous abortion and stillbirth may occur.
imported from: doid.owl
has cross-reference: GARD:10326
has cross-reference: ICD10CM:P37.1
has cross-reference: MESH:D014125
has cross-reference: NCI:C50503
has cross-reference: SNOMEDCT_US_2020_03_01:268875000
has cross-reference: UMLS_CUI:C0040560
alternative_term: Congenital toxoplasmosis
alternative_term: Toxoplasmosis - congen.
has_obo_namespace: disease_ontology
id: DOID:13336
in subset: NCIthesaurus

pedophilia
type: Class
subclass of: paraphilia disorder
imported from: doid.owl
has cross-reference: ICD10CM:F65.4
has cross-reference: ICD9CM:302.2
has cross-reference: MESH:D010378
has cross-reference: NCI:C94355
has cross-reference: SNOMEDCT_US_2020_03_01:192516001
has cross-reference: UMLS_CUI:C0030764
alternative_term: Paedophilia
has_obo_namespace: disease_ontology
id: DOID:13351
in subset: NCIthesaurus

chondromalacia patellae
type: Class
subclass of: bone disease
subclass of: chondromalacia
imported from: doid.owl
has cross-reference: ICD10CM:M22.4
has cross-reference: ICD9CM:717.7
has cross-reference: MESH:D046789
has cross-reference: OMIM:168900
has cross-reference: SNOMEDCT_US_2020_03_01:156521009
has cross-reference: UMLS_CUI:C0008475
alternative_term: Chondromalacia of patella
alternative_term: Chondromalacia patellae
alternative_term: softening of articular cartilage of patella
has_obo_namespace: disease_ontology
id: DOID:13357
comment: OMIM mapping confirmed by DO. [SN].

Ehlers-Danlos syndrome
type: Class
subclass of: DOID 854
textual definition: A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules.
imported from: doid.owl
has_alternative_id: DOID:14696
has cross-reference: GARD:6322
has cross-reference: ICD10CM:Q79.6
has cross-reference: ICD9CM:756.83
has cross-reference: MESH:D004535
has cross-reference: NCI:C34568
has cross-reference: OMIM:PS130000
has cross-reference: SNOMEDCT_US_2020_03_01:268352002
has cross-reference: UMLS_CUI:C0013720
alternative_term: Cutis hyperelastica
alternative_term: elastic skin
has_obo_namespace: disease_ontology
id: DOID:13359
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS]. OMIM mapping by NeuroDevNet. [LS].

reading disorder
type: Class
subclass of: DOID 8927
textual definition: A learning disability involing difficulty reading resulting primarily from neurological factors which affect any part of the reading process.
imported from: doid.owl
has cross-reference: ICD9CM:315.09
has cross-reference: UMLS_CUI:C0154631
has_obo_namespace: disease_ontology
id: DOID:13365

Stiff-Person syndrome
type: Class
subclass of: movement disease
textual definition: A movement disease that is of unknown etiology characterized by progressive rigidity.
imported from: doid.owl
has cross-reference: GARD:5023
has cross-reference: ICD10CM:G25.82
has cross-reference: ICD9CM:333.91
has cross-reference: MESH:D016750
has cross-reference: NCI:C85170
has cross-reference: OMIM:184850
has cross-reference: SNOMEDCT_US_2020_03_01:5217008
has cross-reference: UMLS_CUI:C0085292
alternative_term: Stiff-man syndrome
alternative_term: stiff man syndrome
has_obo_namespace: disease_ontology
id: DOID:13366
in subset: NCIthesaurus

tinea manuum
type: Class
subclass of: skin disease
subclass of: DOID 8913
textual definition: A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling.
imported from: doid.owl
has cross-reference: ICD10CM:B35.2
has cross-reference: ICD9CM:110.2
has cross-reference: SNOMEDCT_US_2020_03_01:48971001
has cross-reference: UMLS_CUI:C0153246
alternative_term: Dermatophytosis of hand
alternative_term: Tinea manus
has_obo_namespace: disease_ontology
id: DOID:13369

scrub typhus
type: Class
subclass of: typhus
textual definition: A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.
imported from: doid.owl
has cross-reference: ICD10CM:A75.3
has cross-reference: ICD9CM:081.2
has cross-reference: MESH:D012612
has cross-reference: SNOMEDCT_US_2020_03_01:73911003
has cross-reference: UMLS_CUI:C0036472
alternative_term: Japanese river fever
alternative_term: Kedani fever
alternative_term: Scrub mite-borne typhus
alternative_term: Tsutsugamushi
alternative_term: Tsutsugamushi disease
has_obo_namespace: disease_ontology
has_related_synonym: Chigger-borne rickettsiosis
has_related_synonym: Chigger-borne typhus
has_related_synonym: Mite-borne rickettsiosis
has_related_synonym: Mite-borne typhus
has_related_synonym: Scrub (mite-borne) typhus
has_related_synonym: Tropical typhus
has_related_synonym: Tsutsugamushi fever
has_related_synonym: Typhus fever due to Rickettsia tsutsugamushi
id: DOID:13371
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

alpha 1-antitrypsin deficiency
type: Class
subclass of: plasma protein metabolism disease
textual definition: A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.
imported from: doid.owl
has cross-reference: GARD:5784
has cross-reference: ICD10CM:E88.01
has cross-reference: ICD9CM:273.4
has cross-reference: MESH:D019896
has cross-reference: NCI:C84397
has cross-reference: OMIM:613490
has cross-reference: SNOMEDCT_US_2020_03_01:30188007
has cross-reference: UMLS_CUI:C0221757
alternative_term: AAT deficiency
has_obo_namespace: disease_ontology
id: DOID:13372
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

fibrodysplasia ossificans progressiva
type: Class
subclass of: autosomal dominant disease
subclass of: connective tissue disease
textual definition: A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.
imported from: doid.owl
has cross-reference: GARD:6445
has cross-reference: ICD10CM:M61.1
has cross-reference: ICD9CM:728.11
has cross-reference: MESH:D009221
has cross-reference: NCI:C3040
has cross-reference: OMIM:135100
has cross-reference: ORDO:337
has cross-reference: SNOMEDCT_US_2020_03_01:82725007
has cross-reference: UMLS_CUI:C0016037
alternative_term: Stone Man Syndrome
alternative_term: myositis ossificans progressiva
alternative_term: progressive myositis ossificans
alternative_term: progressive ossifying myositis
has_obo_namespace: disease_ontology
id: DOID:13374
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Kawasaki disease
type: Class
subclass of: lymphadenitis
textual definition: A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities.
imported from: doid.owl
has cross-reference: EFO:0004246
has cross-reference: GARD:6816
has cross-reference: ICD10CM:M30.3
has cross-reference: ICD9CM:446.1
has cross-reference: MESH:D009080
has cross-reference: NCI:C34825
has cross-reference: OMIM:611775
has cross-reference: SNOMEDCT_US_2020_03_01:75053002
has cross-reference: UMLS_CUI:C0026691
alternative_term: Kawasaki's disease
alternative_term: MLNS
alternative_term: acute febrile MCLS
alternative_term: acute febrile mucocutaneous lymph node syndrome
alternative_term: mucocutaneous lymph node syndrome
has_obo_namespace: disease_ontology
id: DOID:13378
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

congenital dyserythropoietic anemia
type: Class
subclass of: congenital hemolytic anemia
textual definition: A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood.
imported from: doid.owl
has cross-reference: GARD:1999
has cross-reference: ICD10CM:D64.4
has cross-reference: MESH:D000742
has cross-reference: NCI:C84646
has cross-reference: OMIM:PS224120
has cross-reference: ORDO:85
has cross-reference: SNOMEDCT_US_2020_03_01:191272005
has cross-reference: UMLS_CUI:C0002876
alternative_term: congenital dyshaematopoietic anaemia
has_obo_namespace: disease_ontology
id: DOID:1338
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

pernicious anemia
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by a decrease in red blood cells due to malabsorption of vitamin B12, has_symptom fatigue, pallor, shortness of breath, glossitis, ataxia, and/or paresthesia, has_material_basis_in atrophic gastritis, autoimmune disorder affecting the production or function of intrinsic factor, and/or genetic factors.
imported from: doid.owl
has cross-reference: GARD:12671
has cross-reference: ICD10CM:D51.0
has cross-reference: ICD9CM:281.0
has cross-reference: MESH:D000752
has cross-reference: NCI:C2871
has cross-reference: OMIM:170900
has cross-reference: SNOMEDCT_US_2020_03_01:191139001
has cross-reference: UMLS_CUI:C0002892
alternative_term: ANEMIA PERNICIOUS
alternative_term: Addison's anaemia
alternative_term: Biermer's anaemia
alternative_term: Biermer's anemia
alternative_term: pernicious anaemia
has_obo_namespace: disease_ontology
id: DOID:13381
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

megaloblastic anemia
type: Class
subclass of: macrocytic anemia
textual definition: A macrocytic anemia that is characterized by inhibition of DNA synthesis during red blood cell production.
imported from: doid.owl
has cross-reference: ICD10CM:D53.1
has cross-reference: MESH:D000749
has cross-reference: NCI:C34382
has cross-reference: OMIM:261100
has cross-reference: OMIM:613839
has cross-reference: SNOMEDCT_US_2020_03_01:191138009
has cross-reference: UMLS_CUI:C0002888
alternative_term: Grasbeck-Imerslund syndrome
alternative_term: Imerslund-Grasbeck syndrome
alternative_term: MGA1 Norwegian type
alternative_term: RH-MGA1
alternative_term: megaloblastic anaemia
alternative_term: recessive hereditary megaloblastic anaemia 1
alternative_term: recessive hereditary megaloblastic anemia 1
has_obo_namespace: disease_ontology
has_related_synonym: IGS
id: DOID:13382
in subset: NCIthesaurus
comment: Xref MGI.

Diamond-Blackfan anemia
type: Class
subclass of: congenital hypoplastic anemia
textual definition: A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis_insufficient levels of red blood cells due to bone marrow dysfunction.
imported from: doid.owl
has cross-reference: GARD:6274
has cross-reference: ICD10CM:D61.01
has cross-reference: MESH:D029503
has cross-reference: NCI:C61236
has cross-reference: OMIM:PS105650
has cross-reference: ORDO:124
has cross-reference: SNOMEDCT_US_2020_03_01:188588001
alternative_term: Blackfan - Diamond syndrome
alternative_term: chronic constitutional pure red cell anaemia
has_obo_namespace: disease_ontology
id: DOID:1339
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

color blindness
type: Class
subclass of: blindness
textual definition: A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions.
imported from: doid.owl
has cross-reference: ICD10CM:H53.5
has cross-reference: ICD9CM:368.5
has cross-reference: MESH:D003117
has cross-reference: NCI:C3891
has cross-reference: SNOMEDCT_US_2020_03_01:193683001
has cross-reference: UMLS_CUI:C0242225
alternative_term: BLINDNESS COLOR
alternative_term: Colour blindness
alternative_term: Colour vision deficiency
has_obo_namespace: disease_ontology
id: DOID:13399
in subset: NCIthesaurus

pure red-cell aplasia
type: Class
subclass of: aplastic anemia
imported from: doid.owl
has cross-reference: GARD:7504
has cross-reference: MESH:D012010
has cross-reference: NCI:C34974
has cross-reference: SNOMEDCT_US_2020_03_01:191252000
has cross-reference: UMLS_CUI:C0034902
alternative_term: Pure Red cell Aplasia
alternative_term: Pure red cell aplasia
alternative_term: Red cell hypoplasia
alternative_term: primary red cell aplasia
has_obo_namespace: disease_ontology
id: DOID:1340
in subset: NCIthesaurus

angioid streaks
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: MESH:D000793
has cross-reference: OMIM:607140
has cross-reference: UMLS_CUI:C0002982
has_obo_namespace: disease_ontology
id: DOID:13401
comment: OMIM mapping confirmed by DO. [SN].

skin sarcoidosis
type: Class
subclass of: sarcoidosis
subclass of: skin disease
imported from: doid.owl
has cross-reference: ICD10CM:D86.3
has cross-reference: NCI:C34996
has cross-reference: SNOMEDCT_US_2020_03_01:55941000
has cross-reference: UMLS_CUI:C0036203
alternative_term: Cutaneous Sarcoidosis
alternative_term: Cutaneous sarcoid
alternative_term: Cutaneous sarcoidosis
has_obo_namespace: disease_ontology
id: DOID:13402
in subset: NCIthesaurus

cardiac sarcoidosis
type: Class
subclass of: sarcoidosis
textual definition: A sarcoidosis that is characterized by conduction abnormalities, arrhythmias, and congestive heart failure with noncaseating granulomas present on endomyocardial biopsy, and develops_from a type IV hypersensitivity reaction with noncaseating granulomas infiltrating the myocardial tissue, especially that of the left ventricle.
imported from: doid.owl
has cross-reference: NCI:C35589
has cross-reference: SNOMEDCT_US_2020_03_01:75403004
has cross-reference: UMLS_CUI:C0392077
alternative_term: Cardiac sarcoidosis
has_obo_namespace: disease_ontology
id: DOID:13405
in subset: NCIthesaurus

hepatic encephalopathy
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood.
imported from: doid.owl
has cross-reference: GARD:10452
has cross-reference: ICD10CM:K72
has cross-reference: ICD9CM:572.2
has cross-reference: MESH:D006501
has cross-reference: NCI:C79596
has cross-reference: SNOMEDCT_US_2020_03_01:197332007
has cross-reference: UMLS_CUI:C0019151
alternative_term: Portal-systemic encephalopathy
has_obo_namespace: disease_ontology
id: DOID:13413
in subset: NCIthesaurus

congenital hypoplastic anemia
type: Class
subclass of: physical disorder
subclass of: aplastic anemia
imported from: doid.owl
has_alternative_id: DOID:13639
has cross-reference: ICD10CM:D61.0
has cross-reference: ICD10CM:D61.01
has cross-reference: ICD9CM:284.0
has cross-reference: MESH:D029502
has cross-reference: SNOMEDCT_US_2020_03_01:191236003
has cross-reference: SNOMEDCT_US_2020_03_01:267523003
has cross-reference: UMLS_CUI:C0702159
has cross-reference: UMLS_CUI:C0949116
alternative_term: congenital aplastic anaemia
alternative_term: congenital aplastic anemia
alternative_term: congenital hypoplastic anaemia
has_obo_namespace: disease_ontology
has_related_synonym: Constitutional aplastic anaemia
id: DOID:1342

urethritis
type: Class
subclass of: urethral disease
imported from: doid.owl
has_alternative_id: DOID:2863
has cross-reference: ICD10CM:N34.2
has cross-reference: ICD9CM:597.80
has cross-reference: MESH:D014526
has cross-reference: NCI:C26904
has cross-reference: SNOMEDCT_US_2020_03_01:154388003
has cross-reference: SNOMEDCT_US_2020_03_01:31822004
has cross-reference: UMLS_CUI:C0041976
has cross-reference: UMLS_CUI:C0311389
alternative_term: Non-Gonococcal Urethritis
alternative_term: Nongonococcal urethritis
has_obo_namespace: disease_ontology
id: DOID:1343
in subset: NCIthesaurus

glanders
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.
imported from: doid.owl
has cross-reference: GARD:9536
has cross-reference: ICD10CM:A24.0
has cross-reference: ICD9CM:024
has cross-reference: MESH:D005896
has cross-reference: NCI:C34638
has cross-reference: SNOMEDCT_US_2020_03_01:4639008
has cross-reference: UMLS_CUI:C0017589
alternative_term: Farcy pipes
alternative_term: Infection due to Pseudomonas mallei
has_obo_namespace: disease_ontology
id: DOID:13444
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

basilar artery occlusion
type: Class
subclass of: artery disease
subclass of: occlusion precerebral artery
imported from: doid.owl
has cross-reference: ICD10CM:I65.1
has cross-reference: ICD9CM:433.0
has cross-reference: SNOMEDCT_US_2020_03_01:78658006
has cross-reference: UMLS_CUI:C0265098
has_obo_namespace: disease_ontology
id: DOID:13446

coccidioidomycosis
type: Class
subclass of: primary systemic mycosis
textual definition: A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules.
imported from: doid.owl
has_alternative_id: DOID:13981
has cross-reference: GARD:9525
has cross-reference: ICD10CM:B38
has cross-reference: ICD9CM:114
has cross-reference: MESH:D003047
has cross-reference: NCI:C84642
has cross-reference: SNOMEDCT_US_2020_03_01:266218008
has cross-reference: UMLS_CUI:C0009186
alternative_term: primary extrapulmonary coccidioidomycosis
has_obo_namespace: disease_ontology
id: DOID:13450
in subset: NCIthesaurus

scleritis
type: Class
subclass of: scleral disease
imported from: doid.owl
has cross-reference: GARD:12911
has cross-reference: ICD10CM:H15.0
has cross-reference: ICD9CM:379.00
has cross-reference: MESH:D015423
has cross-reference: NCI:C119046
has cross-reference: SNOMEDCT_US_2020_03_01:155201000
has cross-reference: UMLS_CUI:C0036416
has_obo_namespace: disease_ontology
id: DOID:13452
in subset: NCIthesaurus

urethral intrinsic sphincter deficiency
type: Class
subclass of: urethral disease
imported from: doid.owl
has cross-reference: ICD10CM:N36.42
has cross-reference: ICD9CM:599.82
has cross-reference: SNOMEDCT_US_2020_03_01:16031000119101
has cross-reference: UMLS_CUI:C0375381
alternative_term: Intrinsic (urethral) sphincter deficiency [ISD]
has_obo_namespace: disease_ontology
id: DOID:13461

balanitis xerotica obliterans
type: Class
subclass of: balanitis
textual definition: A balantitis characterized by white plaques or patches on genitals.
imported from: doid.owl
has cross-reference: ICD9CM:607.81
has cross-reference: NCI:C3523
has cross-reference: SNOMEDCT_US_2020_03_01:198028006
has cross-reference: UMLS_CUI:C0152460
alternative_term: Penile Lichen Sclerosus
has_obo_namespace: disease_ontology
id: DOID:13477
in subset: NCIthesaurus

thanatophoric dysplasia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.
imported from: doid.owl
has cross-reference: GARD:85
has cross-reference: ICD10CM:Q77.1
has cross-reference: MESH:D013796
has cross-reference: NCI:C85187
has cross-reference: OMIM:187600
has cross-reference: OMIM:187601
has cross-reference: OMIM:273680
has cross-reference: ORDO:1860
has cross-reference: ORDO:2655
has cross-reference: ORDO:93274
has cross-reference: ORDO:93275
has cross-reference: SNOMEDCT_US_2020_03_01:29352008
has cross-reference: UMLS_CUI:C0039743
has_obo_namespace: disease_ontology
id: DOID:13481
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [LS].

Proteus syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by overgrowth of the bones, skin, and other tissues.
imported from: doid.owl
has cross-reference: GARD:7475
has cross-reference: MESH:D016715
has cross-reference: NCI:C85032
has cross-reference: OMIM:176920
has cross-reference: SNOMEDCT_US_2020_03_01:394527003
has cross-reference: UMLS_CUI:C0085261
alternative_term: Wiedemann's syndrome
has_obo_namespace: disease_ontology
id: DOID:13482
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

childhood disintegrative disease
type: Class
subclass of: pervasive developmental disorder
textual definition: A pervasive developmental disorder that is a rare condition characterized by late onset (greater than 3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress.
imported from: doid.owl
has cross-reference: GARD:6040
has cross-reference: ICD10CM:F84.3
has cross-reference: ICD9CM:299.1
has cross-reference: NCI:C97164
has cross-reference: SNOMEDCT_US_2020_03_01:71961003
has cross-reference: UMLS_CUI:C0236791
alternative_term: Disintegrative psychosis
alternative_term: Heller's syndrome
alternative_term: Symbiotic psychosis
has_obo_namespace: disease_ontology
id: DOID:13487
in subset: NCIthesaurus

urethral syndrome
type: Class
subclass of: urethral disease
imported from: doid.owl
has cross-reference: ICD10CM:N34.3
has cross-reference: ICD9CM:597.81
has cross-reference: SNOMEDCT_US_2020_03_01:31273004
has cross-reference: UMLS_CUI:C0156279
has_obo_namespace: disease_ontology
id: DOID:13498

paranasal sinus benign neoplasm
type: Class
subclass of: respiratory system benign neoplasm
subclass of: paranasal sinus disease
imported from: doid.owl
has cross-reference: MESH:D010255
has cross-reference: NCI:C7488
has cross-reference: SNOMEDCT_US_2020_03_01:126675008
has cross-reference: UMLS_CUI:C0030470
alternative_term: neoplasm of accessory sinus
alternative_term: tumor of Accessory sinus
has_obo_namespace: disease_ontology
id: DOID:1350
in subset: NCIthesaurus

Mobius syndrome
type: Class
subclass of: facial nerve disease
textual definition: A facial nerve disease characterized by congenital, uni- or bilateral, non-progressive facial weakness and limited abduction of the eye(s).
imported from: doid.owl
has cross-reference: GARD:8549
has cross-reference: ICD10CM:Q87.0
has cross-reference: MESH:D020331
has cross-reference: NCI:C84893
has cross-reference: OMIM:157900
has cross-reference: SNOMEDCT_US_2020_03_01:89444000
has cross-reference: UMLS_CUI:C0221060
alternative_term: Moebius congenital oculofacial paralysis
alternative_term: Oromandibular-limb hypogenesis spectrum
has_obo_namespace: disease_ontology
id: DOID:13501
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

trigonitis
type: Class
subclass of: cystitis
imported from: doid.owl
has cross-reference: ICD10CM:N30.3
has cross-reference: ICD9CM:595.3
has cross-reference: NCI:C123175
has cross-reference: SNOMEDCT_US_2020_03_01:155885003
has cross-reference: UMLS_CUI:C1261278
has_obo_namespace: disease_ontology
id: DOID:13507
in subset: NCIthesaurus

tuberous sclerosis
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by the growth of numerous noncancerous tumors in many parts of the body.
imported from: doid.owl
has cross-reference: GARD:7830
has cross-reference: ICD10CM:Q85.1
has cross-reference: ICD9CM:759.5
has cross-reference: MESH:D014402
has cross-reference: NCI:C3424
has cross-reference: OMIM:PS191100
has cross-reference: SNOMEDCT_US_2020_03_01:157033002
has cross-reference: UMLS_CUI:C0041341
alternative_term: Bourneville's disease
alternative_term: Epiloia
alternative_term: Tuberose sclerosis
alternative_term: Tuberous sclerosis syndrome
alternative_term: cerebral sclerosis
has_obo_namespace: disease_ontology
id: DOID:13515
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

paranasal sinus disease
type: Class
subclass of: nose disease
imported from: doid.owl
has cross-reference: MESH:D010254
has cross-reference: NCI:C26843
has cross-reference: SNOMEDCT_US_2020_03_01:7393007
has cross-reference: UMLS_CUI:C0030469
alternative_term: disorder of nasal sinus
has_obo_namespace: disease_ontology
id: DOID:1352
in subset: NCIthesaurus

tetanus neonatorum
type: Class
subclass of: tetanus
textual definition: A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has symptom stiff body, has symptom muscle spasms, has symptom difficulty in breathing, and has symptom exhaustion.
imported from: doid.owl
has cross-reference: ICD10CM:A33
has cross-reference: ICD9CM:771.3
has cross-reference: NCI:C116814
has cross-reference: SNOMEDCT_US_2020_03_01:43424001
has cross-reference: UMLS_CUI:C0343312
alternative_term: Tetanus neonatorum
alternative_term: neonatal tetanus
has_obo_namespace: disease_ontology
id: DOID:13521
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

loiasis
type: Class
subclass of: filariasis
subclass of: skin disease
subclass of: eye disease
textual definition: A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.
imported from: doid.owl
has cross-reference: GARD:3283
has cross-reference: ICD10CM:B74.3
has cross-reference: ICD9CM:125.2
has cross-reference: MESH:D008118
has cross-reference: NCI:C34784
has cross-reference: SNOMEDCT_US_2020_03_01:44250009
has cross-reference: UMLS_CUI:C0023968
has_obo_namespace: disease_ontology
id: DOID:13523
in subset: NCIthesaurus

osteopetrosis
type: Class
subclass of: osteosclerosis
textual definition: An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.
imported from: doid.owl
has cross-reference: GARD:4155
has cross-reference: ICD10CM:Q78.2
has cross-reference: ICD9CM:756.52
has cross-reference: MESH:D010022
has cross-reference: NCI:C26840
has cross-reference: OMIM:PS259700
has cross-reference: OMIM:PS607634
has cross-reference: ORDO:667
has cross-reference: SNOMEDCT_US_2020_03_01:205500005
has cross-reference: UMLS_CUI:C0029454
alternative_term: Albers-Schonberg disease
alternative_term: marble bone
has_obo_namespace: disease_ontology
id: DOID:13533
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS].

hyperparathyroidism
type: Class
subclass of: parathyroid gland disease
textual definition: A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body.
imported from: doid.owl
has cross-reference: ICD10CM:E21.3
has cross-reference: ICD9CM:252.0
has cross-reference: MESH:D006961
has cross-reference: NCI:C48259
has cross-reference: OMIM:145000
has cross-reference: OMIM:145001
has cross-reference: OMIM:610071
has cross-reference: ORDO:99879
has cross-reference: SNOMEDCT_US_2020_03_01:190451000
has cross-reference: UMLS_CUI:C0020502
has_obo_namespace: disease_ontology
id: DOID:13543
in subset: NCIthesaurus
comment: Xref MGI.

low tension glaucoma
type: Class
subclass of: open-angle glaucoma
textual definition: An open-angle glaucoma characterized by increased intrinsic resistance to aqueous outflow without known secondary causes, an anatomically narrow anterior chamber angle, or elevated intraocular pressure compared to the average population. Normal tension glaucoma has_symptom progressive decreased vision and progressive loss of peripheral vision.
imported from: doid.owl
has cross-reference: ICD10CM:H40.12
has cross-reference: ICD9CM:365.12
has cross-reference: MESH:D057066
has cross-reference: SNOMEDCT_US_2020_03_01:155124000
has cross-reference: UMLS_CUI:C0152136
alternative_term: Normal tension glaucoma
has_obo_namespace: disease_ontology
id: DOID:13544

interval angle-closure glaucoma
type: Class
subclass of: primary angle-closure glaucoma
textual definition: A primary angle-closure glaucoma characterized by acute closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes suddenly inappropriately elevated threatening optic nerve damage and visual field loss; but that typically resolves spontaneously after several hours, even though it may recur. Interval angle-closure glaucoma has_symptom sudden pain, redness, headache, and blurry vision with haloes around lights that resolves spontaneously. Interval angle-closure glaucoma can be caused by exacerbation of chronic primary angle-closure glaucoma, typically by a medication or state that dilates the eyes and thus narrows the anterior chamber angle, blocking any aqueous outflow.
imported from: doid.owl
has cross-reference: ICD10CM:H40.23
has cross-reference: ICD9CM:365.21
has cross-reference: SNOMEDCT_US_2020_03_01:65460003
has cross-reference: UMLS_CUI:C0154945
alternative_term: Angle-closure glaucoma, subacute
alternative_term: Intermittent angle-closure glaucoma
alternative_term: Prodromal angle closure glaucoma
has_obo_namespace: disease_ontology
id: DOID:13549

angle-closure glaucoma
type: Class
subclass of: glaucoma
textual definition: A glaucoma characterized by closure of the anterior chamber angle such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Angle closure glaucoma can be caused by anatomically narrow angle, injury to the trabecular meshwork, and injuries to the anterior chamber, such as neovascularization and uveitis.
imported from: doid.owl
has cross-reference: MESH:D015812
has cross-reference: NCI:C34639
has cross-reference: SNOMEDCT_US_2020_03_01:270882001
has cross-reference: UMLS_CUI:C0017605
alternative_term: ACG - Angle-closure glaucoma
alternative_term: Angle Closure Glaucoma
alternative_term: Angle-closure glaucoma
alternative_term: Closed angle glaucoma
alternative_term: Narrow cleft glaucoma
alternative_term: primary open-angle glaucoma with narrow angles
has_obo_namespace: disease_ontology
id: DOID:13550
in subset: NCIthesaurus

optic disk drusen
type: Class
subclass of: optic nerve disease
imported from: doid.owl
has cross-reference: ICD10CM:H47.32
has cross-reference: ICD9CM:377.21
has cross-reference: MESH:D015594
has cross-reference: SNOMEDCT_US_2020_03_01:33629003
has cross-reference: UMLS_CUI:C0029128
alternative_term: Drusen of optic disc
alternative_term: optic nerve head drusen
has_obo_namespace: disease_ontology
id: DOID:13561

aspergillosis
type: Class
subclass of: opportunistic mycosis
textual definition: An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.
imported from: doid.owl
has cross-reference: GARD:5856
has cross-reference: ICD10CM:B44
has cross-reference: ICD9CM:117.3
has cross-reference: MESH:D001228
has cross-reference: NCI:C2886
has cross-reference: SNOMEDCT_US_2020_03_01:266218008
has cross-reference: UMLS_CUI:C0004030
alternative_term: Infection due to Aspergillus
has_obo_namespace: disease_ontology
id: DOID:13564
in subset: NCIthesaurus

twin-to-twin transfusion syndrome
type: Class
subclass of: neonatal anemia
imported from: doid.owl
has cross-reference: ICD10CM:O43.02
has cross-reference: MESH:D005330
has cross-reference: NCI:C113824
has cross-reference: SNOMEDCT_US_2020_03_01:13404009
has cross-reference: UMLS_CUI:C2909036
alternative_term: Fetal blood loss from fetal hemorrhage into co-twin
alternative_term: Fetal hemorrhage into co-twin
alternative_term: Twin to twin transfusion
alternative_term: Twin-to-twin blood transfer
has_obo_namespace: disease_ontology
id: DOID:13576
in subset: NCIthesaurus

cholestasis
type: Class
subclass of: bile duct disease
textual definition: A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum.
imported from: doid.owl
has cross-reference: ICD10CM:K83.1
has cross-reference: ICD9CM:576.2
has cross-reference: MESH:D002779
has cross-reference: NCI:C83006
has cross-reference: SNOMEDCT_US_2020_03_01:33688009
has cross-reference: UMLS_CUI:C0008370
alternative_term: Obstruction of bile duct
alternative_term: bile occlusion
has_obo_namespace: disease_ontology
id: DOID:13580
in subset: NCIthesaurus

eclampsia
type: Class
subclass of: pre-eclampsia
textual definition: A pre-eclampsia characterized by the presence of seizures.
imported from: doid.owl
has_alternative_id: DOID:13592
has cross-reference: GARD:6316
has cross-reference: ICD10CM:O15
has cross-reference: MESH:D004461
has cross-reference: NCI:C87167
has cross-reference: SNOMEDCT_US_2020_03_01:156111007
has cross-reference: UMLS_CUI:C0013537
alternative_term: Eclampsia in puerperium
alternative_term: Eclampsia, postpartum
alternative_term: Postpartum eclampsia
has_obo_namespace: disease_ontology
id: DOID:13593
in subset: NCIthesaurus

biliary atresia
type: Class
subclass of: cholestasis
textual definition: A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder.
imported from: doid.owl
has cross-reference: GARD:12010
has cross-reference: ICD10CM:Q44.2
has cross-reference: ICD9CM:751.61
has cross-reference: MESH:D001656
has cross-reference: NCI:C34421
has cross-reference: OMIM:210500
has cross-reference: ORDO:30391
has cross-reference: SNOMEDCT_US_2020_03_01:77480004
has cross-reference: UMLS_CUI:C0005411
alternative_term: Atresia of bile duct
alternative_term: Congenital biliary atresia
alternative_term: biliary atresia, congenital
has_obo_namespace: disease_ontology
id: DOID:13608
in subset: DO rare slim
in subset: NCIthesaurus

frontal sinus benign neoplasm
type: Class
subclass of: paranasal sinus benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4419
has cross-reference: SNOMEDCT_US_2020_03_01:126678005
has cross-reference: UMLS_CUI:C0345672
alternative_term: neoplasm of frontal sinus
alternative_term: tumor of the Frontal sinus
has_obo_namespace: disease_ontology
id: DOID:1361
in subset: NCIthesaurus

patent foramen ovale
type: Class
subclass of: atrial heart septal defect
imported from: doid.owl
has cross-reference: ICD10CM:Q21.1
has cross-reference: MESH:D054092
has cross-reference: NCI:C34619
has cross-reference: SNOMEDCT_US_2020_03_01:268316001
has cross-reference: UMLS_CUI:C0016522
alternative_term: Atrial septal defect within oval fossa
alternative_term: Defect, Patent or persistent, ostium secundum
alternative_term: Ostium secundum type atrial septal defect
alternative_term: Persistent ostium secundum
alternative_term: foramen ovale patent
has_obo_namespace: disease_ontology
id: DOID:13620
in subset: NCIthesaurus

campylobacteriosis
type: Class
subclass of: bacterial infectious disease
subclass of: gastroenteritis
textual definition: A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.
imported from: doid.owl
has_alternative_id: DOID:13621
has cross-reference: MESH:D002169
has cross-reference: SNOMEDCT_US_2020_03_01:86500004
has cross-reference: UMLS_CUI:C0006818
alternative_term: Campylobacteriosis
has_obo_namespace: disease_ontology
id: DOID:13622
in subset: gram-negative bacterial infectious disease

photokeratitis
type: Class
subclass of: keratitis
imported from: doid.owl
has cross-reference: ICD10CM:H16.13
has cross-reference: ICD9CM:370.24
has cross-reference: NCI:C118750
has cross-reference: SNOMEDCT_US_2020_03_01:1714005
has cross-reference: UMLS_CUI:C0155078
has_obo_namespace: disease_ontology
id: DOID:13626
in subset: NCIthesaurus

favism
type: Class
subclass of: glucosephosphate dehydrogenase deficiency
textual definition: A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.
imported from: doid.owl
has cross-reference: ICD10CM:D55.0
has cross-reference: MESH:D005236
has cross-reference: NCI:C34607
has cross-reference: SNOMEDCT_US_2020_03_01:154801000
has cross-reference: UMLS_CUI:C0015702
has_obo_namespace: disease_ontology
id: DOID:13628
in subset: NCIthesaurus

dentine erosion
type: Class
subclass of: tooth erosion
imported from: doid.owl
has cross-reference: ICD9CM:521.32
has cross-reference: UMLS_CUI:C1456162
has_obo_namespace: disease_ontology
id: DOID:13629

Fanconi anemia
type: Class
subclass of: congenital hypoplastic anemia
textual definition: A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair.
imported from: doid.owl
has cross-reference: GARD:6425
has cross-reference: ICD10CM:D61.09
has cross-reference: MESH:D005199
has cross-reference: NCI:C62505
has cross-reference: OMIM:PS227650
has cross-reference: ORDO:84
has cross-reference: SNOMEDCT_US_2020_03_01:30575002
has cross-reference: UMLS_CUI:C0015625
alternative_term: Fanconi anaemia
alternative_term: Fanconi pancytopenia
alternative_term: Fanconi panmyelopathy
alternative_term: Fanconi's anaemia
alternative_term: Fanconi's anemia
has_obo_namespace: disease_ontology
id: DOID:13636
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS].

exfoliation syndrome
type: Class
subclass of: phacogenic glaucoma
subclass of: iris disease
textual definition: A phacogenic glaucoma that is characterized by open-angle glaucoma related to deposition of extracellular fibrillar material in anterior segment structures, which blocks aqueous fluid outflow, raises intraocular pressure, and leads to eventual optic nerve atrophy and visual field loss. Exfoliation syndrome has_symptom progressive decreased vision, especially peripheral vision. Exfoliation syndrome is caused by age-related deposition of fibrillar material in anterior segment structures.
imported from: doid.owl
has cross-reference: EFO:0004235
has cross-reference: ICD9CM:365.52
has cross-reference: MESH:D017889
has cross-reference: NCI:C129025
has cross-reference: OMIM:177650
has cross-reference: SNOMEDCT_US_2020_03_01:111514006
has cross-reference: UMLS_CUI:C0206368
alternative_term: Pseudoexfoliation glaucoma
alternative_term: Pseudoexfoliation syndrome
has_obo_namespace: disease_ontology
id: DOID:13641
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

SAPHO syndrome
type: Class
subclass of: syndrome
imported from: doid.owl
has cross-reference: GARD:7606
has cross-reference: MESH:D020083
has cross-reference: NCI:C119049
has cross-reference: SNOMEDCT_US_2020_03_01:60684003
has cross-reference: UMLS_CUI:C0263859
alternative_term: Synovitis, acne, pustulosis palmaris, hyperostosis, osteomyelitis syndrome
has_obo_namespace: disease_ontology
id: DOID:13677
in subset: NCIthesaurus

premature ejaculation
type: Class
subclass of: psychosexual disorder
imported from: doid.owl
has cross-reference: ICD10CM:F52.4
has cross-reference: ICD9CM:302.75
has cross-reference: MESH:D061686
has cross-reference: NCI:C94349
has cross-reference: SNOMEDCT_US_2020_03_01:123302009
has cross-reference: UMLS_CUI:C0033038
has_obo_namespace: disease_ontology
id: DOID:13709
in subset: NCIthesaurus

dental fluorosis
type: Class
subclass of: tooth disease
imported from: doid.owl
has cross-reference: ICD10CM:K00.3
has cross-reference: ICD9CM:520.3
has cross-reference: MESH:D009050
has cross-reference: NCI:C85059
has cross-reference: SNOMEDCT_US_2020_03_01:30265004
has cross-reference: UMLS_CUI:C0026618
alternative_term: Intrinsic enamel discolouration of fluorosis
alternative_term: Mottled teeth
alternative_term: Mottling of enamel
has_obo_namespace: disease_ontology
id: DOID:13711
in subset: NCIthesaurus

mature cataract
type: Class
subclass of: DOID 9669
textual definition: A senile cataract that is characterized by full white or brunescent opacification of the lens of the eye such that the red reflex is obscured. It is a later stage of senile cataracts and is caused by a multifactorial etiology related to aging.
imported from: doid.owl
has cross-reference: SNOMEDCT_US_2020_03_01:193590000
has cross-reference: UMLS_CUI:C0152257
alternative_term: Total or mature cataract
alternative_term: Total, mature senile cataract
has_obo_namespace: disease_ontology
id: DOID:13717

neuroschistosomiasis
type: Class
subclass of: schistosomiasis
subclass of: spinal cord disease
subclass of: DOID 936
textual definition: A schistosomiasis that involves parasitic infection of the brain and spinal cord by Schistosoma haematobium, Schistosoma mansoni or Schistosoma japonicum causing acute or subacute myelopathy, focal central nervous system impairment, seizures and increased intracranial pressure.
imported from: doid.owl
has cross-reference: MESH:D020818
has cross-reference: UMLS_CUI:C0752191
has_obo_namespace: disease_ontology
id: DOID:13722

scurvy
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by vitamin C (ascorbic acid) deficiency and has_symptom fatigue, weakness, anemia, petechiae, corkscrew hair, gingivitis, and poor wound healing.
imported from: doid.owl
has cross-reference: GARD:10406
has cross-reference: ICD10CM:E54
has cross-reference: MESH:D012614
has cross-reference: NCI:C35010
has cross-reference: OMIM:240400
has cross-reference: SNOMEDCT_US_2020_03_01:267493006
has cross-reference: UMLS_CUI:C0036474
has_obo_namespace: disease_ontology
id: DOID:13724
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

beriberi
type: Class
subclass of: thiamine deficiency disease
textual definition: A thiamine deficiency disease that is characterized by being severe and chronic.
imported from: doid.owl
has cross-reference: GARD:9948
has cross-reference: ICD10CM:E51.1
has cross-reference: ICD9CM:265.0
has cross-reference: MESH:D001602
has cross-reference: NCI:C34418
has cross-reference: SNOMEDCT_US_2020_03_01:267491008
has cross-reference: UMLS_CUI:C0005122
has_obo_namespace: disease_ontology
id: DOID:13725
in subset: NCIthesaurus

endometrial stromal nodule
type: Class
subclass of: uterine benign neoplasm
textual definition: An uterine benign neoplasm that has_material_basis_in cells reminiscent of proliferative phase endometrial stroma.
imported from: doid.owl
has cross-reference: NCI:C4262
has cross-reference: SNOMEDCT_US_2020_03_01:189810002
has cross-reference: UMLS_CUI:C0334485
has_obo_namespace: disease_ontology
id: DOID:1373
in subset: NCIthesaurus

panophthalmitis
type: Class
subclass of: DOID 9724
imported from: doid.owl
has cross-reference: ICD9CM:360.02
has cross-reference: MESH:D010202
has cross-reference: SNOMEDCT_US_2020_03_01:33382000
has cross-reference: UMLS_CUI:C0030332
has_obo_namespace: disease_ontology
id: DOID:13732

excessive tearing
type: Class
subclass of: lacrimal apparatus disease
imported from: doid.owl
has cross-reference: ICD10CM:H04.2
has cross-reference: ICD9CM:375.2
has cross-reference: MESH:D007766
has cross-reference: NCI:C50552
has cross-reference: SNOMEDCT_US_2020_03_01:49393005
has cross-reference: UMLS_CUI:C0152227
alternative_term: Epiphora
alternative_term: Excessive tear production
alternative_term: Watering eye
has_obo_namespace: disease_ontology
id: DOID:13757
in subset: NCIthesaurus

Pthirus pubis infestation
type: Class
subclass of: lice infestation
textual definition: A lice infestation that involves parasitic infestation by pubic lice Pthirus pubis, which are found in the pubic hair, less commonly in eyebrows, eyelashes, beard, mustache, armpit, perianal area, groin, trunk and scalp. The symptoms include itching in the pubic and groin area. Intense itching leads to scratching which can cause sores and secondary bacterial infection of the skin.
imported from: doid.owl
has cross-reference: ICD10CM:B85.3
has cross-reference: ICD9CM:132.2
has cross-reference: NCI:C35777
has cross-reference: SNOMEDCT_US_2020_03_01:71011005
has cross-reference: UMLS_CUI:C0030759
alternative_term: Infestation by Phthirus pubis
alternative_term: Pediculosis Pubis
alternative_term: Pediculus pubis
alternative_term: Phthiriasis pubis
alternative_term: Phthirus pubis
alternative_term: Phthirus/pediculus pubis - pubic lice - crabs
alternative_term: crabs
has_obo_namespace: disease_ontology
id: DOID:13760
in subset: NCIthesaurus
in subset: sexually transmitted infectious disease

clonorchiasis
type: Class
subclass of: liver disease
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.
imported from: doid.owl
has cross-reference: ICD10CM:B66.1
has cross-reference: ICD9CM:121.1
has cross-reference: MESH:D003003
has cross-reference: SNOMEDCT_US_2020_03_01:11938002
has cross-reference: UMLS_CUI:C0009021
alternative_term: Oriental liver fluke disease
has_obo_namespace: disease_ontology
id: DOID:13767

opisthorchiasis
type: Class
subclass of: gallbladder disease
subclass of: pancreas disease
subclass of: liver disease
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma.
imported from: doid.owl
has cross-reference: GARD:9746
has cross-reference: ICD10CM:B66.0
has cross-reference: ICD9CM:121.0
has cross-reference: MESH:D009889
has cross-reference: SNOMEDCT_US_2020_03_01:187124006
has cross-reference: UMLS_CUI:C0029106
alternative_term: Infection by Opisthorchis
has_obo_namespace: disease_ontology
id: DOID:13768

Addison's disease
type: Class
subclass of: adrenal cortical hypofunction
textual definition: An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands.
imported from: doid.owl
has cross-reference: GARD:5740
has cross-reference: ICD10CM:E27.1
has cross-reference: MESH:D000224
has cross-reference: NCI:C26689
has cross-reference: OMIM:103230
has cross-reference: OMIM:240200
has cross-reference: SNOMEDCT_US_2020_03_01:363732003
has cross-reference: UMLS_CUI:C0001403
alternative_term: Addison disease
alternative_term: Addison disease, chronic adrenal insufficiency
alternative_term: HYPOADRENOCORTICISM, FAMILIAL
alternative_term: primary adrenocortical insufficiency
alternative_term: primary hypoadrenalism
has_obo_namespace: disease_ontology
id: DOID:13774
in subset: NCIthesaurus

epidermodysplasia verruciformis
type: Class
subclass of: autosomal recessive disease
subclass of: primary immunodeficiency disease
textual definition: A primary immunodeficiency disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.
imported from: doid.owl
has cross-reference: GARD:6357
has cross-reference: MESH:D004819
has cross-reference: NCI:C126877
has cross-reference: OMIM:PS226400
has cross-reference: ORDO:302
has cross-reference: SNOMEDCT_US_2020_03_01:19138001
has cross-reference: UMLS_CUI:C0014522
has_obo_namespace: disease_ontology
id: DOID:13777
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chancroid
type: Class
subclass of: primary bacterial infectious disease
subclass of: skin disease
textual definition: A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has_material_basis_in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers.
imported from: doid.owl
has cross-reference: GARD:9522
has cross-reference: ICD10CM:A57
has cross-reference: ICD9CM:099.0
has cross-reference: MESH:D002602
has cross-reference: SNOMEDCT_US_2020_03_01:154391003
has cross-reference: UMLS_CUI:C0007947
alternative_term: Ulcus molle, skin
has_obo_namespace: disease_ontology
id: DOID:13778
in subset: gram-negative bacterial infectious disease
in subset: sexually transmitted infectious disease

hypermobility syndrome
type: Class
subclass of: arthropathy
imported from: doid.owl
has cross-reference: ICD10CM:M35.7
has cross-reference: ICD9CM:728.5
has cross-reference: SNOMEDCT_US_2020_03_01:85551004
has cross-reference: UMLS_CUI:C0152093
alternative_term: benign joint hypermobility
has_obo_namespace: disease_ontology
id: DOID:13781

acute tympanitis
type: Class
subclass of: tympanic membrane disease
imported from: doid.owl
has cross-reference: ICD10CM:H73.0
has cross-reference: ICD9CM:384.00
has cross-reference: SNOMEDCT_US_2020_03_01:297009
has cross-reference: UMLS_CUI:C0155460
alternative_term: acute myringitis
has_obo_namespace: disease_ontology
id: DOID:13790

endometrial cancer
type: Class
subclass of: endometriosis
subclass of: uterine cancer
textual definition: A uterine cancer that is located_in tissues lining the uterus.
imported from: doid.owl
has_alternative_id: DOID:5654
has cross-reference: EFO:0004230
has cross-reference: GARD:11981
has cross-reference: ICD10CM:C54.1
has cross-reference: KEGG:05213
has cross-reference: MESH:D016889
has cross-reference: NCI:C27815
has cross-reference: NCI:C3012
has cross-reference: OMIM:608089
has cross-reference: SNOMEDCT_US_2020_03_01:123844007
has cross-reference: UMLS_CUI:C0007103
has cross-reference: UMLS_CUI:C0014170
alternative_term: endometrial Ca
alternative_term: endometrial neoplasm
alternative_term: malignant endometrial neoplasm
alternative_term: malignant neoplasm of endometrium
alternative_term: neoplasm of endometrium
alternative_term: primary malignant neoplasm of endometrium
alternative_term: tumor of Endometrium
has_obo_namespace: disease_ontology
id: DOID:1380
in subset: DO cancer slim
in subset: NCIthesaurus

inclusion conjunctivitis
type: Class
subclass of: commensal bacterial infectious disease
subclass of: conjunctival disease
textual definition: A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.
imported from: doid.owl
has cross-reference: GARD:6777
has cross-reference: ICD10CM:A74.0
has cross-reference: ICD9CM:077.0
has cross-reference: MESH:D003235
has cross-reference: SNOMEDCT_US_2020_03_01:111840005
has cross-reference: UMLS_CUI:C0009770
alternative_term: Chlamydial conjunctivitis
alternative_term: Inclusion blennorrhoea
alternative_term: adult inclusion conjunctivitis
alternative_term: inclusion blenorrhea
has_obo_namespace: disease_ontology
has_related_synonym: Paratrachoma
id: DOID:13800
in subset: gram-negative bacterial infectious disease

familial combined hyperlipidemia
type: Class
subclass of: familial hyperlipidemia
imported from: doid.owl
has cross-reference: ICD10CM:E78.49
has cross-reference: MESH:D006950
has cross-reference: NCI:C35637
has cross-reference: OMIM:144250
has cross-reference: SNOMEDCT_US_2020_03_01:48190005
has cross-reference: UMLS_CUI:C0020474
alternative_term: familial multiple lipoprotein-type hyperlipidemia
alternative_term: hyperbetalipoproteinemia with prebetalipoproteinemia
alternative_term: mixed hyperlipidaemia
alternative_term: type IIb hyperlipoproteinemia
has_obo_namespace: disease_ontology
id: DOID:13809
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Fox-Fordyce disease
type: Class
subclass of: sweat gland disease
textual definition: A sweat gland disease that is characterized by dilatation of the follicular infundibulum with hyperkeratosis, acanthosis, and spongiosis with perifollicular inflammation leading to hair loss and has_symptom flesh colored papules with hair loss and pruritis, especially of the axilla.
imported from: doid.owl
has cross-reference: GARD:6462
has cross-reference: ICD10CM:L75.2
has cross-reference: ICD9CM:705.82
has cross-reference: MESH:D005588
has cross-reference: NCI:C84716
has cross-reference: SNOMEDCT_US_2020_03_01:254682006
has cross-reference: UMLS_CUI:C0016632
alternative_term: Fox Fordyce disease
has_obo_namespace: disease_ontology
id: DOID:1381
in subset: NCIthesaurus

lymphogranuloma venereum
type: Class
subclass of: commensal bacterial infectious disease
subclass of: DOID 9113
textual definition: A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis.
imported from: doid.owl
has cross-reference: GARD:9545
has cross-reference: ICD10CM:A55
has cross-reference: ICD9CM:099.1
has cross-reference: MESH:D008219
has cross-reference: NCI:C26822
has cross-reference: SNOMEDCT_US_2020_03_01:266213004
has cross-reference: UMLS_CUI:C0024286
alternative_term: Climatic or tropical bubo
alternative_term: Durand-Nicolas-Favre disease
alternative_term: Lymphogranuloma inguinale
alternative_term: Poradenitis inguinale
alternative_term: Strumous bubo
has_obo_namespace: disease_ontology
id: DOID:13819
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: sexually transmitted infectious disease

miliaria
type: Class
subclass of: sweat gland disease
textual definition: A sweat gland disease that is characterized by blocked eccrine sweat glands and ducts.
imported from: doid.owl
has cross-reference: ICD10CM:L74.3
has cross-reference: MESH:D008883
has cross-reference: NCI:C34820
has cross-reference: SNOMEDCT_US_2020_03_01:63951004
has cross-reference: UMLS_CUI:C0026113
alternative_term: eccrine miliaria
alternative_term: heat rash
alternative_term: sweat rash
has_obo_namespace: disease_ontology
id: DOID:1382
in subset: NCIthesaurus

sweat gland disease
type: Class
subclass of: skin disease
textual definition: A skin disease located_in the sweat glands.
imported from: doid.owl
has cross-reference: ICD10CM:L74.9
has cross-reference: ICD9CM:705.9
has cross-reference: MESH:D013543
has cross-reference: SNOMEDCT_US_2020_03_01:88232005
has cross-reference: UMLS_CUI:C0038986
has_obo_namespace: disease_ontology
id: DOID:1383

patent ductus arteriosus
type: Class
subclass of: congenital heart disease
imported from: doid.owl
has cross-reference: GARD:7342
has cross-reference: ICD10CM:Q25.0
has cross-reference: ICD9CM:747.0
has cross-reference: MESH:D004374
has cross-reference: NCI:C84492
has cross-reference: OMIM:607411
has cross-reference: SNOMEDCT_US_2020_03_01:156928009
has cross-reference: UMLS_CUI:C0013274
alternative_term: Patent ductus Botalli
has_obo_namespace: disease_ontology
has_related_synonym: ductus arteriosus, Patent
id: DOID:13832
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

abetalipoproteinemia
type: Class
subclass of: autosomal recessive disease
subclass of: hypolipoproteinemia
textual definition: A hypolipoproteinemia that is characterized by an inablility to fully absorb dietary fats, cholesterol and fat-soluble vitamins, has_material_basis_in an autosomal recessive disorder of lipid metabolism that has_material_basis_in mutation in the microsomal triglyceride transfer protein that catalyzes the transport of lipids and is required in the secretion of BETA-LIPOPROTEINS.
imported from: doid.owl
has cross-reference: GARD:5
has cross-reference: ICD10CM:E78.6
has cross-reference: MESH:D000012
has cross-reference: NCI:C84525
has cross-reference: OMIM:200100
has cross-reference: SNOMEDCT_US_2020_03_01:83123000
has cross-reference: UMLS_CUI:C0000744
alternative_term: familial hypobetalipoproteinemia
alternative_term: microsomal triglyceride transfer protein deficiency disease
has_obo_namespace: disease_ontology
id: DOID:1386
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

acute closed-angle glaucoma
type: Class
subclass of: primary angle-closure glaucoma
textual definition: A primary angle-closure glaucoma characterized by acute closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes suddenly inappropriately elevated threatening futher optic nerve damage and visual field loss. Acute closed-angle glaucoma has_symptom sudden pain, redness, headache, and blurry vision with haloes around lights. Acute closed-angle glaucoma can be caused by exacerbation of chronic primary angle-closure glaucoma, typically by a medication or state that dilates the eyes and thus narrows the anterior chamber angle, blocking any aqueous outflow.
imported from: doid.owl
has cross-reference: ICD10CM:H40.21
has cross-reference: ICD9CM:365.22
has cross-reference: SNOMEDCT_US_2020_03_01:30041005
has cross-reference: UMLS_CUI:C0154946
alternative_term: acute angle-closure glaucoma
has_obo_namespace: disease_ontology
id: DOID:13862

multiple cranial nerve palsy
type: Class
subclass of: glossopharyngeal nerve disease
imported from: doid.owl
has cross-reference: ICD10CM:G52.7
has cross-reference: ICD9CM:352.6
has cross-reference: SNOMEDCT_US_2020_03_01:78152008
has cross-reference: UMLS_CUI:C0154733
alternative_term: Multiple cranial nerve palsies
alternative_term: Multiple cranial nerve palsy
has_obo_namespace: disease_ontology
id: DOID:13866

hypoactive sexual desire disorder
type: Class
subclass of: psychosexual disorder
imported from: doid.owl
has cross-reference: ICD10CM:F52.0
has cross-reference: ICD9CM:302.71
has cross-reference: MESH:D020018
has cross-reference: NCI:C94337
has cross-reference: SNOMEDCT_US_2020_03_01:78889008
has cross-reference: UMLS_CUI:C0020594
alternative_term: Lack or loss of sexual desire
has_obo_namespace: disease_ontology
id: DOID:13868
in subset: NCIthesaurus

hypolipoproteinemia
type: Class
subclass of: lipid metabolism disorder
imported from: doid.owl
has cross-reference: GARD:8394
has cross-reference: ICD10CM:E78.6
has cross-reference: ICD9CM:272.5
has cross-reference: MESH:D007009
has cross-reference: SNOMEDCT_US_2020_03_01:363140000
has cross-reference: UMLS_CUI:C0020623
alternative_term: Hypolipoproteinaemia
has_obo_namespace: disease_ontology
has_related_synonym: Lipoprotein deficiencies
id: DOID:1387

Tangier disease
type: Class
subclass of: hypolipoproteinemia
imported from: doid.owl
has cross-reference: GARD:7731
has cross-reference: ICD10CM:E78.6
has cross-reference: MESH:D013631
has cross-reference: NCI:C85182
has cross-reference: OMIM:205400
has cross-reference: SNOMEDCT_US_2020_03_01:190783007
has cross-reference: UMLS_CUI:C0039292
alternative_term: familial alpha-lipoprotein deficiency
alternative_term: familial high density lipoprotein deficiency
alternative_term: familial hypoalphalipoproteinemia
has_obo_namespace: disease_ontology
id: DOID:1388
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

sick sinus syndrome
type: Class
subclass of: sinoatrial node disease
imported from: doid.owl
has cross-reference: ICD10CM:I49.5
has cross-reference: MESH:D012804
has cross-reference: NCI:C62244
has cross-reference: OMIM:163800
has cross-reference: OMIM:608567
has cross-reference: ORDO:166282
has cross-reference: SNOMEDCT_US_2020_03_01:266307005
has cross-reference: UMLS_CUI:C0037052
alternative_term: sinus node infection
has_obo_namespace: disease_ontology
id: DOID:13884
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

polyneuropathy
type: Class
subclass of: peripheral nervous system disease
textual definition: A peripheral system disease that is characterized by damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain.
imported from: doid.owl
has cross-reference: ICD10CM:A69.22
has cross-reference: MESH:D011115
has cross-reference: NCI:C26951
has cross-reference: SNOMEDCT_US_2020_03_01:193166009
has cross-reference: UMLS_CUI:C0152025
has_obo_namespace: disease_ontology
id: DOID:1389
in subset: DO FlyBase slim
in subset: NCIthesaurus

squamous cell papilloma
type: Class
subclass of: papilloma
imported from: doid.owl
has cross-reference: MESH:D010212
has cross-reference: NCI:C3712
has cross-reference: SNOMEDCT_US_2020_03_01:63451008
has cross-reference: UMLS_CUI:C0205874
alternative_term: Epidermoid papilloma
has_obo_namespace: disease_ontology
id: DOID:139
in subset: NCIthesaurus

hypobetalipoproteinemia
type: Class
subclass of: hypolipoproteinemia
textual definition: A hypolipoproteinemia characterized by permanently low levels of apolipoprotein B and LDL cholesterol resulting from an impaired ability to absorb and transport fats.
imported from: doid.owl
has cross-reference: MESH:D006995
has cross-reference: SNOMEDCT_US_2020_03_01:190786004
has cross-reference: UMLS_CUI:C0020597
alternative_term: Hypo-beta-lipoproteinemia
has_obo_namespace: disease_ontology
id: DOID:1390

Norum disease
type: Class
subclass of: hypolipoproteinemia
imported from: doid.owl
has cross-reference: ICD10CM:E78.6
has cross-reference: MESH:D007863
has cross-reference: NCI:C84813
has cross-reference: OMIM:245900
has cross-reference: SNOMEDCT_US_2020_03_01:238091006
has cross-reference: UMLS_CUI:C0023195
alternative_term: LECITHIN:CHOLESTEROL ACYLTRANSFERASE DEFICIENCY
alternative_term: lecithin acyltransferase deficiency
has_obo_namespace: disease_ontology
id: DOID:1391
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

red color blindness
type: Class
subclass of: color blindness
imported from: doid.owl
has cross-reference: ICD9CM:368.51
has cross-reference: MESH:D003117
has cross-reference: OMIM:303900
has cross-reference: SNOMEDCT_US_2020_03_01:51445007
has cross-reference: UMLS_CUI:C0155015
alternative_term: Protan defect
alternative_term: Protanopia
has_obo_namespace: disease_ontology
id: DOID:13910

achromatopsia
type: Class
subclass of: color blindness
textual definition: A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance.
imported from: doid.owl
has cross-reference: ICD10CM:H53.51
has cross-reference: ICD9CM:368.54
has cross-reference: MESH:D003117
has cross-reference: NCI:C84528
has cross-reference: ORDO:49382
has cross-reference: SNOMEDCT_US_2020_03_01:56852002
has cross-reference: UMLS_CUI:C0152200
alternative_term: ACHM
alternative_term: Monochromatism
has_obo_namespace: disease_ontology
id: DOID:13911
in subset: DO rare slim
in subset: NCIthesaurus

irregular astigmatism
type: Class
subclass of: astigmatism
imported from: doid.owl
has cross-reference: ICD10CM:H52.21
has cross-reference: ICD9CM:367.22
has cross-reference: SNOMEDCT_US_2020_03_01:47099006
has cross-reference: UMLS_CUI:C0152194
has_obo_namespace: disease_ontology
id: DOID:13919

pseudopapilledema
type: Class
subclass of: visual pathway disease
imported from: doid.owl
has cross-reference: ICD9CM:377.24
has cross-reference: MESH:C562401
has cross-reference: OMIM:177800
has cross-reference: SNOMEDCT_US_2020_03_01:57138009
has cross-reference: UMLS_CUI:C0155300
has_obo_namespace: disease_ontology
id: DOID:1392
comment: OMIM mapping confirmed by DO. [SN].

eosinophilic esophagitis
type: Class
subclass of: esophagitis
textual definition: An esophagitis characterized by inflammation involving eosinophils located_in esophagus.
imported from: doid.owl
has cross-reference: EFO:0004232
has cross-reference: ICD10CM:K20.0
has cross-reference: ICD9CM:530.13
has cross-reference: MESH:D057765
has cross-reference: NCI:C27105
has cross-reference: OMIM:610247
has cross-reference: OMIM:613412
has cross-reference: ORDO:73247
has cross-reference: SNOMEDCT_US_2020_03_01:235599003
has cross-reference: UMLS_CUI:C0341106
has_obo_namespace: disease_ontology
id: DOID:13922
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

lacrimal duct obstruction
type: Class
subclass of: lacrimal apparatus disease
imported from: doid.owl
has cross-reference: MESH:D007767
has cross-reference: NCI:C34757
has cross-reference: SNOMEDCT_US_2020_03_01:95769009
has cross-reference: UMLS_CUI:C0022906
alternative_term: Blocked lacrimal canaliculus
alternative_term: Obstruction of lacrimal canaliculus
alternative_term: Obstruction of lacrimal ducts
has_obo_namespace: disease_ontology
id: DOID:13929
in subset: NCIthesaurus

visual pathway disease
type: Class
subclass of: eye disease
textual definition: An eye disease that affects the neural pathway from the optic nerve to the visual cortex, through which light is interpreted as an image.
imported from: doid.owl
has cross-reference: ICD10CM:H47.9
has cross-reference: NCI:C35342
has cross-reference: SNOMEDCT_US_2020_03_01:54767005
has cross-reference: UMLS_CUI:C0155287
has_obo_namespace: disease_ontology
id: DOID:1393
in subset: NCIthesaurus

facial paralysis
type: Class
subclass of: facial nerve disease
imported from: doid.owl
has cross-reference: ICD10CM:G51.0
has cross-reference: MESH:D005158
has cross-reference: NCI:C26769
has cross-reference: SNOMEDCT_US_2020_03_01:90039006
has cross-reference: UMLS_CUI:C0015469
alternative_term: Facial Palsy
has_obo_namespace: disease_ontology
id: DOID:13934
in subset: NCIthesaurus

amenorrhea
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is characterized by the absence of menstruation.
imported from: doid.owl
has cross-reference: ICD10CM:N91.2
has cross-reference: ICD9CM:626.0
has cross-reference: MESH:D000568
has cross-reference: NCI:C61443
has cross-reference: SNOMEDCT_US_2020_03_01:156034000
has cross-reference: UMLS_CUI:C0002453
alternative_term: absence of menstruation
alternative_term: amenia
has_obo_namespace: disease_ontology
id: DOID:13938
in subset: NCIthesaurus

urinary schistosomiasis
type: Class
subclass of: schistosomiasis
subclass of: bladder disease
textual definition: A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.
imported from: doid.owl
has cross-reference: ICD9CM:120.0
has cross-reference: MESH:D012553
has cross-reference: NCI:C39294
has cross-reference: SNOMEDCT_US_2020_03_01:60979006
has cross-reference: UMLS_CUI:C0276926
alternative_term: Schistosoma Hematobium Infection
alternative_term: Schistosoma haematobium
alternative_term: Schistosoma hematobium infectious disease
alternative_term: Schistosomiasis due to schistosoma haematobium
alternative_term: Schistosomiasis of bladder
alternative_term: Vesical schistosomiasis
alternative_term: bladder Schistosomiasis
alternative_term: cystitis with bilharziasis
has_obo_namespace: disease_ontology
has_related_synonym: Schistosoma haematobium infection
id: DOID:1394
in subset: NCIthesaurus
in subset: zoonotic infectious disease

benign paroxysmal positional nystagmus
type: Class
subclass of: DOID 9847
imported from: doid.owl
has cross-reference: ICD9CM:386.11
has cross-reference: MESH:D065635
has cross-reference: OMIM:193007
has cross-reference: OMIM:613106
has cross-reference: SNOMEDCT_US_2020_03_01:111541001
has cross-reference: UMLS_CUI:C0155502
alternative_term: benign paroxysmal positional vertigo
has_obo_namespace: disease_ontology
id: DOID:13941
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

CADASIL
type: Class
subclass of: leukodystrophy
textual definition: A leukodystrophy characterized by recurrent subcortical ischemic stroke and cognitive impairment.
imported from: doid.owl
has cross-reference: GARD:1049
has cross-reference: ICD10CM:I67.850
has cross-reference: MESH:D046589
has cross-reference: NCI:C84606
has cross-reference: OMIM:600142
has cross-reference: OMIM:PS125310
has cross-reference: ORDO:136
has cross-reference: SNOMEDCT_US_2020_03_01:390723008
has cross-reference: UMLS_CUI:C0751587
alternative_term: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
alternative_term: hereditary multi-infarct dementia
has_obo_namespace: disease_ontology
id: DOID:13945
in subset: NCIthesaurus

bladder neck obstruction
type: Class
subclass of: bladder disease
imported from: doid.owl
has cross-reference: ICD10CM:N32.0
has cross-reference: ICD9CM:596.0
has cross-reference: MESH:D001748
has cross-reference: NCI:C79541
has cross-reference: SNOMEDCT_US_2020_03_01:197859007
has cross-reference: UMLS_CUI:C0005694
alternative_term: Obstruction of bladder neck or vesicourethral orifice
has_obo_namespace: disease_ontology
id: DOID:13948
in subset: NCIthesaurus

interstitial cystitis
type: Class
subclass of: cystitis
imported from: doid.owl
has cross-reference: GARD:6787
has cross-reference: MESH:D018856
has cross-reference: NCI:C27189
has cross-reference: SNOMEDCT_US_2020_03_01:197834003
has cross-reference: UMLS_CUI:C0282488
alternative_term: ulcerative cystitis
has_obo_namespace: disease_ontology
id: DOID:13949
in subset: NCIthesaurus

schistosomiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.
imported from: doid.owl
has cross-reference: GARD:9687
has cross-reference: ICD9CM:120.8
has cross-reference: SNOMEDCT_US_2020_03_01:187116001
has cross-reference: UMLS_CUI:C0029827
has_obo_namespace: disease_ontology
id: DOID:1395

Morgagni cataract
type: Class
subclass of: DOID 9669
textual definition: A senile cataract that is characterized by dense white opacification of the lens and milky fluid in the lens capsule such that the dense nucleus of the lens sinks in the surrounding fluid. It is the late stage of senile cataracts and is caused by a multifactorial etiology related to aging.
imported from: doid.owl
has cross-reference: ICD9CM:366.18
has cross-reference: SNOMEDCT_US_2020_03_01:247065006
has cross-reference: UMLS_CUI:C0152258
alternative_term: hypermature cataract
has_obo_namespace: disease_ontology
id: DOID:13964

parasitic infectious disease
type: Class
subclass of: disease by infectious agent
textual definition: A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host.
imported from: doid.owl
has_alternative_id: DOID:11681
has_alternative_id: DOID:13509
has_alternative_id: DOID:1396
has_alternative_id: DOID:1494
has_alternative_id: DOID:2114
has_alternative_id: DOID:2293
has_alternative_id: DOID:2922
has_alternative_id: DOID:3564
has_alternative_id: DOID:4191
has_alternative_id: DOID:886
has_alternative_id: DOID:948
has_alternative_id: DOID:9639
has_alternative_id: DOID:9644
has cross-reference: ICD10CM:H44.12
has cross-reference: ICD9CM:360.13
has cross-reference: NCI:C34587
has cross-reference: SNOMEDCT_US_2020_03_01:57100005
has cross-reference: UMLS_CUI:C0014238
alternative_term: Ectoparasitic disease
alternative_term: parasitemia
has_obo_namespace: disease_ontology
id: DOID:1398
in subset: DO AGR slim
in subset: NCIthesaurus

cleidocranial dysplasia
type: Class
subclass of: autosomal dominant disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in undeveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull.
imported from: doid.owl
has cross-reference: GARD:6118
has cross-reference: ICD10CM:Q74.0
has cross-reference: MESH:D002973
has cross-reference: NCI:C75020
has cross-reference: OMIM:119600
has cross-reference: OMIM:216330
has cross-reference: ORDO:1452
has cross-reference: SNOMEDCT_US_2020_03_01:65976001
has cross-reference: UMLS_CUI:C0008928
alternative_term: Marie-Sainton Disease
alternative_term: cleidocranial dysostosis
has_obo_namespace: disease_ontology
id: DOID:13994
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

small intestine lymphoma
type: Class
subclass of: lymphoma
subclass of: small intestine cancer
imported from: doid.owl
has cross-reference: NCI:C4007
has cross-reference: SNOMEDCT_US_2020_03_01:449074003
has cross-reference: UMLS_CUI:C0278805
alternative_term: small intestinal Lymphoma
has_obo_namespace: disease_ontology
id: DOID:13996
in subset: NCIthesaurus

lacrimal apparatus disease
type: Class
subclass of: eye disease
textual definition: An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye.
imported from: doid.owl
has cross-reference: ICD10CM:H04
has cross-reference: ICD9CM:375
has cross-reference: MESH:D007766
has cross-reference: NCI:C26809
has cross-reference: SNOMEDCT_US_2020_03_01:267740009
has cross-reference: UMLS_CUI:C0022904
has_obo_namespace: disease_ontology
id: DOID:1400
in subset: NCIthesaurus

splenic artery aneurysm
type: Class
subclass of: artery disease
imported from: doid.owl
has cross-reference: ICD9CM:442.83
has cross-reference: SNOMEDCT_US_2020_03_01:70405009
has cross-reference: UMLS_CUI:C0155747
has_obo_namespace: disease_ontology
id: DOID:14006

alcoholic liver cirrhosis
type: Class
subclass of: liver cirrhosis
imported from: doid.owl
has cross-reference: ICD10CM:K70.3
has cross-reference: ICD9CM:571.2
has cross-reference: MESH:D008104
has cross-reference: NCI:C34782
has cross-reference: SNOMEDCT_US_2020_03_01:420054005
has cross-reference: UMLS_CUI:C0023891
alternative_term: Alcoholic Cirrhosis
alternative_term: Alcoholic cirrhosis of liver
alternative_term: Laennec's cirrhosis
alternative_term: Laennec's cirrhosis, alcoholic
alternative_term: Portal cirrhosis
has_obo_namespace: disease_ontology
id: DOID:14018
in subset: NCIthesaurus

folic acid deficiency anemia
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has_material_basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines.
imported from: doid.owl
has cross-reference: ICD10CM:D52
has cross-reference: ICD9CM:281.2
has cross-reference: SNOMEDCT_US_2020_03_01:85649008
has cross-reference: UMLS_CUI:C0151482
alternative_term: Folate deficiency anaemia
alternative_term: Folate deficiency anemia
alternative_term: Folate-deficiency anaemia
alternative_term: Folate-deficiency anemia
alternative_term: Folate-deficient megaloblastic anaemia
alternative_term: folic acid deficiency anaemia
has_obo_namespace: disease_ontology
id: DOID:14026

POEMS syndrome
type: Class
subclass of: blood protein disease
textual definition: A blood protein disease that is characterized by polyneuropathy, oranomegaly, endocrinopathy, monoclonal gammopathy, and skin changes, especially hyperpigmentation.
imported from: doid.owl
has cross-reference: GARD:7411
has cross-reference: MESH:D016878
has cross-reference: NCI:C80303
has cross-reference: SNOMEDCT_US_2020_03_01:79268002
has cross-reference: UMLS_CUI:C0085404
has_obo_namespace: disease_ontology
id: DOID:14039
in subset: NCIthesaurus

autoimmune polyendocrine syndrome
type: Class
subclass of: autoimmune disease of endocrine system
textual definition: An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.
imported from: doid.owl
has cross-reference: ICD10CM:E31.0
has cross-reference: MESH:D016884
has cross-reference: NCI:C84576
has cross-reference: SNOMEDCT_US_2020_03_01:41864002
has cross-reference: UMLS_CUI:C0085409
alternative_term: Autoimmune polyglandular failure
alternative_term: Lloyd's syndrome
alternative_term: autoimmune polyendocrinopathy
has_obo_namespace: disease_ontology
id: DOID:14040
in subset: NCIthesaurus

bipolar I disorder
type: Class
subclass of: bipolar disorder
textual definition: A bipolar disorder that is characterized by at least one manic or mixed episode.
imported from: doid.owl
has cross-reference: ICD9CM:296.50
has cross-reference: SNOMEDCT_US_2020_03_01:49468007
has cross-reference: UMLS_CUI:C0236773
has_obo_namespace: disease_ontology
id: DOID:14042

phaeohyphomycosis
type: Class
subclass of: primary systemic mycosis
subclass of: paranasal sinus disease
subclass of: skin disease
subclass of: lung disease
subclass of: DOID 936
textual definition: A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.
imported from: doid.owl
has cross-reference: GARD:12803
has cross-reference: MESH:D060446
alternative_term: Infection by dematiacious fungi
alternative_term: phaehyphomycosis
has_obo_namespace: disease_ontology
id: DOID:14049

primary angle-closure glaucoma
type: Class
subclass of: angle-closure glaucoma
textual definition: An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.
imported from: doid.owl
has cross-reference: ICD10CM:H40.2
has cross-reference: ICD9CM:365.2
has cross-reference: SNOMEDCT_US_2020_03_01:193544008
has cross-reference: UMLS_CUI:C0017606
alternative_term: primary Angle Closure Glaucoma
has_obo_namespace: disease_ontology
id: DOID:1405

iritis
type: Class
subclass of: iris disease
imported from: doid.owl
has cross-reference: MESH:D007500
has cross-reference: NCI:C50621
has cross-reference: SNOMEDCT_US_2020_03_01:65074000
has cross-reference: UMLS_CUI:C0022081
has_obo_namespace: disease_ontology
id: DOID:1406
in subset: NCIthesaurus

acute poststreptococcal glomerulonephritis
type: Class
subclass of: glomerulonephritis
imported from: doid.owl
has cross-reference: NCI:C35443
has cross-reference: SNOMEDCT_US_2020_03_01:68544003
has cross-reference: UMLS_CUI:C0403414
alternative_term: Post-Streptococcal Glomerulonephritis
has_obo_namespace: disease_ontology
id: DOID:14064
in subset: NCIthesaurus

acute diffuse nephritis
type: Class
subclass of: diffuse glomerulonephritis
imported from: doid.owl
has cross-reference: NCI:C35587
has cross-reference: SNOMEDCT_US_2020_03_01:197585004
has cross-reference: UMLS_CUI:C0341689
alternative_term: acute Diffuse Glomerulonephritis
has_obo_namespace: disease_ontology
id: DOID:14066
in subset: NCIthesaurus

blackwater fever
type: Class
subclass of: malaria
textual definition: A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.
imported from: doid.owl
has cross-reference: ICD9CM:084.8
has cross-reference: MESH:D001742
has cross-reference: NCI:C34426
has cross-reference: SNOMEDCT_US_2020_03_01:56625005
has cross-reference: UMLS_CUI:C0005681
alternative_term: Black water fever
alternative_term: Blackwater fever
alternative_term: Hemoglobinuric, malaria
alternative_term: Malarial Hemoglobinuria
has_obo_namespace: disease_ontology
id: DOID:14068
in subset: NCIthesaurus

anterior uveitis
type: Class
subclass of: panuveitis
imported from: doid.owl
has cross-reference: GARD:10941
has cross-reference: MESH:D014606
has cross-reference: NCI:C35109
has cross-reference: SNOMEDCT_US_2020_03_01:193500005
has cross-reference: UMLS_CUI:C0042165
has_obo_namespace: disease_ontology
id: DOID:1407
in subset: NCIthesaurus

vestibular nystagmus
type: Class
subclass of: globe disease
imported from: doid.owl
has cross-reference: ICD9CM:379.54
has cross-reference: SNOMEDCT_US_2020_03_01:46888001
has cross-reference: UMLS_CUI:C0155379
alternative_term: Nystagmus associated with disorder of the vestibular system
has_obo_namespace: disease_ontology
id: DOID:14070

epicondylitis
type: Class
subclass of: bone inflammation disease
textual definition: A bone inflammation disease that results_in inflammation located_in epicondyle.
imported from: doid.owl
has_alternative_id: DOID:14162
has cross-reference: ICD10CM:M77.1
has cross-reference: ICD9CM:726.32
has cross-reference: MESH:D013716
has cross-reference: NCI:C34589
has cross-reference: NCI:C35067
has cross-reference: SNOMEDCT_US_2020_03_01:156659008
has cross-reference: SNOMEDCT_US_2020_03_01:268088003
has cross-reference: UMLS_CUI:C0014488
has cross-reference: UMLS_CUI:C0039516
alternative_term: Lateral epicondylitis
alternative_term: andrel epicondylitis
alternative_term: archer's elbow
alternative_term: golfer's elbow
alternative_term: hockey elbow
alternative_term: medial epicondylitis
has_obo_namespace: disease_ontology
has_related_synonym: shooter's elbow
has_related_synonym: tennis elbow
id: DOID:14087
in subset: NCIthesaurus

root caries
type: Class
subclass of: dental caries
imported from: doid.owl
has cross-reference: ICD9CM:521.08
has cross-reference: MESH:D017213
has cross-reference: SNOMEDCT_US_2020_03_01:30512007
has cross-reference: UMLS_CUI:C0162644
alternative_term: Cementum caries
alternative_term: Dental caries of root surface
alternative_term: Root caries
has_obo_namespace: disease_ontology
id: DOID:14089

boutonneuse fever
type: Class
subclass of: spotted fever
textual definition: A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities.
imported from: doid.owl
has_alternative_id: DOID:0050039
has_alternative_id: DOID:0050040
has_alternative_id: DOID:0050044
has_alternative_id: DOID:0050045
has cross-reference: ICD10CM:A77.1
has cross-reference: ICD9CM:082.1
has cross-reference: MESH:D001907
has cross-reference: SNOMEDCT_US_2020_03_01:186779000
has cross-reference: UMLS_CUI:C0006060
alternative_term: African tick typhus
alternative_term: Rickettsia conorii spotted fever
alternative_term: South African tick-bite fever
alternative_term: african tick typhus
alternative_term: kenya tick typhus
alternative_term: marseilles fever
has_obo_namespace: disease_ontology
has_related_synonym: Boutonneuse disease
has_related_synonym: Conor and Bruch's disease
has_related_synonym: Kenya fever
has_related_synonym: Kenyan tick typhus
has_related_synonym: Mediterranean spotted fever
has_related_synonym: Mediterranean tick fever
id: DOID:14095
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

anus cancer
type: Class
subclass of: anus disease
subclass of: large intestine cancer
textual definition: A large intestine cancer that is located_in the anus.
imported from: doid.owl
has_alternative_id: DOID:12240
has cross-reference: GARD:9300
has cross-reference: ICD10CM:C21.0
has cross-reference: ICD10CM:C21.1
has cross-reference: ICD9CM:154.2
has cross-reference: ICD9CM:154.3
has cross-reference: NCI:C7379
has cross-reference: SNOMEDCT_US_2020_03_01:93669004
has cross-reference: SNOMEDCT_US_2020_03_01:93676009
has cross-reference: UMLS_CUI:C0153445
has cross-reference: UMLS_CUI:C0153446
alternative_term: anal cancer
alternative_term: malignant anal tumor
has_obo_namespace: disease_ontology
id: DOID:14110
in subset: NCIthesaurus

median rhomboid glossitis
type: Class
subclass of: glossitis
imported from: doid.owl
has cross-reference: ICD10CM:K14.2
has cross-reference: ICD9CM:529.2
has cross-reference: SNOMEDCT_US_2020_03_01:7522008
has cross-reference: UMLS_CUI:C0155963
alternative_term: Persistent tuberculum impar
has_obo_namespace: disease_ontology
id: DOID:14111

toxic shock syndrome
type: Class
subclass of: commensal bacterial infectious disease
textual definition: A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.
imported from: doid.owl
has cross-reference: ICD10CM:A48.3
has cross-reference: ICD9CM:040.82
has cross-reference: MESH:D012772
has cross-reference: NCI:C35498
has cross-reference: SNOMEDCT_US_2020_03_01:18504008
has cross-reference: UMLS_CUI:C0600327
alternative_term: TSS
alternative_term: Toxic Shock syndrome
alternative_term: Toxic shock syndrome
alternative_term: toxic shock
has_obo_namespace: disease_ontology
id: DOID:14115
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

familial lipoprotein lipase deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: familial chylomicronemia syndrome
textual definition: A familial hyperlipemia characterized by a deficiency of the enzyme lipoprotein lipase and the subsequent build up of chylomicrons and increased plasma concentration of triglycerides.
imported from: doid.owl
has cross-reference: GARD:12241
has cross-reference: ICD10CM:E78.3
has cross-reference: ICD9CM:272.3
has cross-reference: MESH:D008072
has cross-reference: NCI:C84771
has cross-reference: OMIM:238600
has cross-reference: ORDO:309015
has cross-reference: SNOMEDCT_US_2020_03_01:34171006
has cross-reference: UMLS_CUI:C0023817
alternative_term: Fredrickson type I hyperlipoproteinemia
alternative_term: Fredrickson type I lipaemia
alternative_term: familial LPL deficiency
alternative_term: familial chylomicronemia syndrome
alternative_term: familial hyperlipoproteinemia type I
alternative_term: hypercholesterinaemic xanthomatosis
alternative_term: hyperchylomicronemia
alternative_term: mixed hyperglyceridemia
has_obo_namespace: disease_ontology
id: DOID:14118
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

bacteriuria
type: Class
subclass of: urinary system disease
textual definition: A urinary system disease which consists of the presence of bacteria in urine.
imported from: doid.owl
has cross-reference: ICD10CM:R82.71
has cross-reference: MEDDRA:10004056
has cross-reference: MESH:D001437
has cross-reference: SNOMEDCT_US_2020_03_01:61373006
has cross-reference: UMLS_CUI:C0004659
has_obo_namespace: disease_ontology
id: DOID:1412

lateral cystocele
type: Class
subclass of: prolapse of female genital organ
textual definition: A prolapse of the female genital organ that is characterized by the descent of the bladder causing a bulge in the anterolateral vaginal walls.
imported from: doid.owl
has cross-reference: ICD10CM:N81.12
has cross-reference: ICD9CM:618.02
has cross-reference: SNOMEDCT_US_2020_03_01:441891001
has cross-reference: UMLS_CUI:C2711750
has_obo_namespace: disease_ontology
id: DOID:14130

Masters-Allen syndrome
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is characterized by an excessively mobile uterus secondary to lacerations of the broad and cardinal ligaments, specific tenderness with movement of the cervix and previous untoward obstetrics events, such as premature maternal voluntary efforts, precipate delivery, and forceps delivery.
imported from: doid.owl
has cross-reference: ICD9CM:620.6
has cross-reference: SNOMEDCT_US_2020_03_01:69186005
has cross-reference: UMLS_CUI:C0152079
alternative_term: Broad ligament laceration syndrome
has_obo_namespace: disease_ontology
id: DOID:14133

ovarian dysfunction
type: Class
subclass of: ovarian disease
textual definition: An ovarian disease that is characterized by irregular or absent ovulation.
imported from: doid.owl
has cross-reference: ICD9CM:256.3
has cross-reference: SNOMEDCT_US_2020_03_01:267399006
has cross-reference: UMLS_CUI:C0029697
has_obo_namespace: disease_ontology
id: DOID:1414

ureterolithiasis
type: Class
subclass of: ureteral disease
textual definition: An ureteral disease this is characterized by the formation of stoney concentrations in the ureter.
imported from: doid.owl
has cross-reference: ICD10CM:N20.1
has cross-reference: ICD9CM:592.1
has cross-reference: MESH:D053039
has cross-reference: NCI:C114696
has cross-reference: SNOMEDCT_US_2020_03_01:31054009
has cross-reference: UMLS_CUI:C0041952
alternative_term: Ureteric calculus
alternative_term: Ureteric stone
alternative_term: calculus of ureter
has_obo_namespace: disease_ontology
id: DOID:14146
in subset: NCIthesaurus

gyrate atrophy
type: Class
subclass of: choroid disease
imported from: doid.owl
has cross-reference: GARD:6556
has cross-reference: MESH:D015799
has cross-reference: NCI:C84744
has cross-reference: OMIM:258870
has cross-reference: SNOMEDCT_US_2020_03_01:314467007
has cross-reference: UMLS_CUI:C0018425
alternative_term: Gyrate atrophy of the choroid and/or retina
alternative_term: Ornithinemia with gyrate atrophy
alternative_term: gyrate atrophy of the retina
has_obo_namespace: disease_ontology
id: DOID:1415
in subset: NCIthesaurus
comment: OMIM mapping by NeuroDevNet. [LS].

choroid disease
type: Class
subclass of: uveal disease
imported from: doid.owl
has cross-reference: ICD10CM:H31.9
has cross-reference: ICD9CM:363.9
has cross-reference: MESH:D015862
has cross-reference: NCI:C34468
has cross-reference: SNOMEDCT_US_2020_03_01:193480005
has cross-reference: UMLS_CUI:C0008521
has_obo_namespace: disease_ontology
id: DOID:1417
in subset: NCIthesaurus

central neurocytoma
type: Class
subclass of: cerebral ventricle cancer
imported from: doid.owl
has cross-reference: MESH:D018306
has cross-reference: NCI:C3791
has cross-reference: SNOMEDCT_US_2020_03_01:302832007
has cross-reference: UMLS_CUI:C0206719
alternative_term: Neurolipocytoma
has_obo_namespace: disease_ontology
id: DOID:14174
in subset: NCIthesaurus

von Hippel-Lindau disease
type: Class
subclass of: hemangioblastoma
imported from: doid.owl
has cross-reference: GARD:7855
has cross-reference: ICD10CM:Q85.8
has cross-reference: MESH:D006623
has cross-reference: NCI:C3105
has cross-reference: OMIM:193300
has cross-reference: SNOMEDCT_US_2020_03_01:46659004
has cross-reference: UMLS_CUI:C0019562
alternative_term: Hippel Lindau syndrome
alternative_term: Von Hippel-Lindau syndrome
alternative_term: von Hippel-Lindau syndrome
has_obo_namespace: disease_ontology
id: DOID:14175
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

congenital hypogammaglobulinemia
type: Class
subclass of: physical disorder
subclass of: B cell deficiency
imported from: doid.owl
has cross-reference: ICD9CM:279.04
has cross-reference: SNOMEDCT_US_2020_03_01:190983003
has cross-reference: UMLS_CUI:C1457897
alternative_term: Congenital hypogammaglobulinaemia
alternative_term: Congenital hypogammaglobulinemia
has_obo_namespace: disease_ontology
id: DOID:14177

X-linked agammaglobulinemia
type: Class
subclass of: X-linked recessive disease
subclass of: agammaglobulinemia
textual definition: An agammaglobulinemia that is that has_material_basis_in a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.
imported from: doid.owl
has cross-reference: MESH:C537409
has cross-reference: NCI:C3822
has cross-reference: OMIM:300755
has cross-reference: ORDO:47
has cross-reference: SNOMEDCT_US_2020_03_01:65880007
has cross-reference: UMLS_CUI:C0221026
alternative_term: BTK deficiency
alternative_term: Bruton agammaglobulinemia tyrosine kinase deficiency
alternative_term: Bruton's Sex-Linked Agammaglobulinemia
alternative_term: Bruton's agammaglobulinaemia
alternative_term: Bruton's type agammaglobulinemia
alternative_term: Bruton-type agammaglobulinemia
has_obo_namespace: disease_ontology
id: DOID:14179
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

calcific tendinitis
type: Class
subclass of: DOID 971
imported from: doid.owl
has cross-reference: ICD10CM:M75.3
has cross-reference: ICD9CM:726.11
has cross-reference: SNOMEDCT_US_2020_03_01:239957000
has cross-reference: UMLS_CUI:C0158303
has_obo_namespace: disease_ontology
id: DOID:14181

alcoholic neuropathy
type: Class
subclass of: inflammatory and toxic neuropathy
imported from: doid.owl
has cross-reference: ICD10CM:G62.1
has cross-reference: ICD9CM:357.5
has cross-reference: MESH:D020269
has cross-reference: NCI:C26926
has cross-reference: SNOMEDCT_US_2020_03_01:7916009
has cross-reference: UMLS_CUI:C0085677
alternative_term: Alcohol-related polyneuropathy
alternative_term: Alcoholic polyneuropathy
has_obo_namespace: disease_ontology
id: DOID:14183
in subset: NCIthesaurus

frozen shoulder
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease characterized by restriction of both active and passive range of motion located_in the scapulohumeral joint and has_symptom pain and has_symptom restricted range of motion.
imported from: doid.owl
has cross-reference: ICD10CM:M75.0
has cross-reference: ICD9CM:726.0
has cross-reference: MESH:D002062
has cross-reference: SNOMEDCT_US_2020_03_01:156664007
has cross-reference: UMLS_CUI:C0311223
alternative_term: Adhesive capsulitis of shoulder
alternative_term: adhesions-capsulitis,shoulder
has_obo_namespace: disease_ontology
id: DOID:14188

adult dermatomyositis
type: Class
subclass of: dermatomyositis
imported from: doid.owl
alternative_term: adult onset dermatomyositis
has_obo_namespace: disease_ontology
id: DOID:14202

hypophosphatasia
type: Class
subclass of: autosomal genetic disease
subclass of: syndrome
textual definition: A syndrome characterized by disruption of mineralization of bones and teeth that has_material_basis_in mutation in ALPL on chromosome 1p36.12.
imported from: doid.owl
has_alternative_id: DOID:14763
has cross-reference: GARD:6734
has cross-reference: ICD10CM:E83.39
has cross-reference: MESH:C562440
has cross-reference: MESH:D007014
has cross-reference: NCI:C26798
has cross-reference: ORDO:436
has cross-reference: SNOMEDCT_US_2020_03_01:30174008
has cross-reference: SNOMEDCT_US_2020_03_01:70848009
has cross-reference: UMLS_CUI:C0020630
has cross-reference: UMLS_CUI:C0220743
alternative_term: childhood hypophosphatasia
alternative_term: deficiency of alkaline phosphatase
alternative_term: hypophospatasia, childhood
has_obo_namespace: disease_ontology
id: DOID:14213
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

dihydropyrimidine dehydrogenase deficiency
type: Class
subclass of: purine-pyrimidine metabolic disorder
textual definition: A purine-pyrimidine metabolic disorder that is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine.
imported from: doid.owl
has cross-reference: GARD:19
has cross-reference: MESH:D054067
has cross-reference: NCI:C84672
has cross-reference: OMIM:274270
has cross-reference: SNOMEDCT_US_2020_03_01:238016000
has cross-reference: UMLS_CUI:C1959620
has cross-reference: UMLS_CUI:C3495551
alternative_term: Dihydropyrimidine dehydrogenase deficiency
alternative_term: Dihydrouracil Dehydrogenase deficiency
alternative_term: familial pyrimidinaemia
alternative_term: thymine-uracilurea
has_obo_namespace: disease_ontology
id: DOID:14218
in subset: NCIthesaurus

renal tubular acidosis
type: Class
subclass of: renal tubular transport disease
textual definition: A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine.
imported from: doid.owl
has cross-reference: GARD:7552
has cross-reference: ICD10CM:N25.89
has cross-reference: MESH:D000141
has cross-reference: NCI:C28129
has cross-reference: OMIM:179830
has cross-reference: OMIM:267200
has cross-reference: OMIM:602722
has cross-reference: SNOMEDCT_US_2020_03_01:1776003
has cross-reference: UMLS_CUI:C0001126
has_obo_namespace: disease_ontology
id: DOID:14219
in subset: NCIthesaurus
comment: Xref MGI.

abdominal obesity-metabolic syndrome 1
type: Class
subclass of: abdominal obesity-metabolic syndrome
textual definition: An abdominal obesity-metabolic syndrome characterized by insulin resistance and hyperinsulinemia, dyslipidemia, essential hypertension, abdominal obesity, glucose intolerance or noninsulin-dependent diabetes mellitus and an increased risk of cardiovascular events.
imported from: doid.owl
has cross-reference: EFO:0000195
has cross-reference: GARD:9226
has cross-reference: ICD10CM:E88.81
has cross-reference: ICD9CM:277.7
has cross-reference: MESH:D024821
has cross-reference: NCI:C84442
has cross-reference: OMIM:605552
has cross-reference: SNOMEDCT_US_2020_03_01:190394009
has cross-reference: UMLS_CUI:C0524620
alternative_term: abdominal obesity-metabolic syndrome 1
alternative_term: dysmetabolic syndrome X
alternative_term: metabolic syndrome X
has_obo_namespace: disease_ontology
id: DOID:14221
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

ochronosis
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease characterized by bluish-brown discoloration of connective tissues that develops from the deposition of homogentisic acid and subsequent oxidation and polymerization reactions.
imported from: doid.owl
has cross-reference: GARD:7231
has cross-reference: ICD10CM:E70.29
has cross-reference: MESH:D009794
has cross-reference: NCI:C84938
has cross-reference: SNOMEDCT_US_2020_03_01:21924005
has cross-reference: UMLS_CUI:C0028817
has_obo_namespace: disease_ontology
id: DOID:14223
in subset: NCIthesaurus

acute frontal sinusitis
type: Class
subclass of: frontal sinusitis
textual definition: A frontal sinusitis which lasts for less than 4 weeks.
imported from: doid.owl
has cross-reference: ICD10CM:J01.1
has cross-reference: ICD9CM:461.1
has cross-reference: SNOMEDCT_US_2020_03_01:155500003
has cross-reference: UMLS_CUI:C0155805
has_obo_namespace: disease_ontology
id: DOID:14225

azoospermia
type: Class
subclass of: male infertility
textual definition: A male infertility disease characterized by the absence of any measurable level of sperm in semen.
imported from: doid.owl
has cross-reference: EFO:0000279
has cross-reference: ICD10CM:N46.0
has cross-reference: ICD9CM:606.0
has cross-reference: MESH:D053713
has cross-reference: NCI:C80076
has cross-reference: ORDO:217034
has cross-reference: SNOMEDCT_US_2020_03_01:425558002
has cross-reference: UMLS_CUI:C0004509
alternative_term: spermatogenic failure
has_obo_namespace: disease_ontology
id: DOID:14227
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

oligospermia
type: Class
subclass of: male infertility
textual definition: A male fertility issue defined as a low sperm concentration in the ejaculate.
imported from: doid.owl
has cross-reference: ICD10CM:N46.1
has cross-reference: ICD9CM:606.1
has cross-reference: MESH:D009845
has cross-reference: NCI:C34860
has cross-reference: UMLS_CUI:C0028960
has_obo_namespace: disease_ontology
id: DOID:14228
in subset: NCIthesaurus

scleromalacia perforans
type: Class
subclass of: scleral disease
textual definition: A scleral disease that is characterized by a painless severe necrotizing scleritis where the sclera is white, avascular, and thin. The choroid can become exposed leading to infarction and necrosis of related areas; the sclera can also thin such that the dark uvea protrudes through the front of the eye, forming a staphyloma which has_symptom loss of vision and appearance of a dark bulge. Scleromalacia perforans is usually caused by a rare complication of autoimmune disease like rheumatoid arthritis.
imported from: doid.owl
has cross-reference: ICD10CM:H15.05
has cross-reference: ICD9CM:379.04
has cross-reference: SNOMEDCT_US_2020_03_01:26664005
has cross-reference: UMLS_CUI:C0155354
has_obo_namespace: disease_ontology
id: DOID:14230

chronic purulent otitis media
type: Class
subclass of: suppurative otitis media
textual definition: A suppurative otitis media which is persistent and long-lasting.
imported from: doid.owl
has cross-reference: ICD10CM:H66.3
has cross-reference: ICD9CM:382.3
has cross-reference: NCI:C128386
has cross-reference: SNOMEDCT_US_2020_03_01:38394007
has cross-reference: UMLS_CUI:C0271454
alternative_term: chronic suppurative otitis media
has_obo_namespace: disease_ontology
id: DOID:14247
in subset: NCIthesaurus

Down syndrome
type: Class
subclass of: chromosomal duplication syndrome
textual definition: A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability.
imported from: doid.owl
has cross-reference: GARD:10247
has cross-reference: ICD10CM:Q90
has cross-reference: ICD9CM:758.0
has cross-reference: MESH:D004314
has cross-reference: NCI:C2993
has cross-reference: OMIM:190685
has cross-reference: ORDO:870
has cross-reference: SNOMEDCT_US_2020_03_01:41040004
has cross-reference: UMLS_CUI:C0013080
alternative_term: Complete trisomy 21 syndrome
alternative_term: Down's syndrome
alternative_term: Down's syndrome - trisomy 21
alternative_term: Downs syndrome
alternative_term: G Trisomy
alternative_term: trisomy 21 syndrome
has_obo_namespace: disease_ontology
id: DOID:14250
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

vitreoretinal dystrophy
type: Class
subclass of: fundus dystrophy
imported from: doid.owl
has cross-reference: ICD10CM:H35.51
has cross-reference: ICD9CM:362.73
has cross-reference: SNOMEDCT_US_2020_03_01:79556007
has cross-reference: UMLS_CUI:C0154863
alternative_term: Vitreoretinal dystrophies
has_obo_namespace: disease_ontology
id: DOID:14251

adult-onset Still's disease
type: Class
subclass of: rheumatoid arthritis
textual definition: A rheumatoid arthritis that is characterized by high fevers, rash, sore throat and joint pain.
imported from: doid.owl
has cross-reference: GARD:436
has cross-reference: ICD10CM:M06.1
has cross-reference: MESH:D016706
has cross-reference: SNOMEDCT_US_2020_03_01:239920006
has cross-reference: UMLS_CUI:C0085253
alternative_term: adult onset Still's disease
alternative_term: adult-onset Still disease
has_obo_namespace: disease_ontology
id: DOID:14256

ureteral disease
type: Class
subclass of: urinary system disease
textual definition: A urinary system disease that is located_in the ureter.
imported from: doid.owl
has cross-reference: MESH:D014515
has cross-reference: UMLS_CUI:C0041954
has_obo_namespace: disease_ontology
id: DOID:1426
in subset: NCIthesaurus

fragile X syndrome
type: Class
subclass of: X-linked dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function.
imported from: doid.owl
has cross-reference: GARD:6464
has cross-reference: ICD10CM:Q99.2
has cross-reference: ICD9CM:759.83
has cross-reference: MESH:D005600
has cross-reference: NCI:C84717
has cross-reference: OMIM:300624
has cross-reference: ORDO:908
has cross-reference: SNOMEDCT_US_2020_03_01:390007001
has cross-reference: UMLS_CUI:C0016667
alternative_term: FRAGILE X MENTAL RETARDATION SYNDROME
alternative_term: MARKER X SYNDROME
alternative_term: MARTIN-BELL SYNDROME
has_obo_namespace: disease_ontology
id: DOID:14261
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

benign neonatal seizures
type: Class
subclass of: neonatal period electroclinical syndrome
textual definition: A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion.
imported from: doid.owl
has cross-reference: MESH:D020936
has cross-reference: NCI:C84593
has cross-reference: OMIM:121200
has cross-reference: OMIM:121201
has cross-reference: OMIM:269720
has cross-reference: ORDO:1949
has cross-reference: SNOMEDCT_US_2020_03_01:38281008
has cross-reference: UMLS_CUI:C0270851
alternative_term: benign familial neonatal seizures
alternative_term: benign neonatal convulsions
has_obo_namespace: disease_ontology
id: DOID:14264
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

pulmonary valve insufficiency
type: Class
subclass of: pulmonary valve disease
textual definition: A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur.
imported from: doid.owl
has_alternative_id: DOID:11210
has cross-reference: MESH:D011665
has cross-reference: NCI:C51447
has cross-reference: SNOMEDCT_US_2020_03_01:91434003
has cross-reference: UMLS_CUI:C0034088
alternative_term: Pulmonic insufficiency
alternative_term: Pulmonic valve regurgitation
alternative_term: pulmonary incompetence
alternative_term: pulmonary incompetence, non-rheumatic
alternative_term: pulmonary insufficiency following trauma and surgery
alternative_term: pulmonary regurg.
alternative_term: pulmonary regurgitation
has_obo_namespace: disease_ontology
id: DOID:14265
in subset: NCIthesaurus
comment: Replacing outdated UMLS CUI.

sclerosing cholangitis
type: Class
subclass of: DOID 9446
imported from: doid.owl
has cross-reference: EFO:0004268
has cross-reference: ICD10CM:K83.09
has cross-reference: MESH:D015209
has cross-reference: SNOMEDCT_US_2020_03_01:4032000
has cross-reference: UMLS_CUI:C0008313
alternative_term: fibrosing cholangitis
has_obo_namespace: disease_ontology
id: DOID:14268

ascending cholangitis
type: Class
subclass of: DOID 9446
imported from: doid.owl
has cross-reference: ICD10CM:K83.09
has cross-reference: NCI:C35372
has cross-reference: SNOMEDCT_US_2020_03_01:26918003
has cross-reference: UMLS_CUI:C0311273
alternative_term: Ascending Cholangitis
alternative_term: Ascending cholangitis
has_obo_namespace: disease_ontology
id: DOID:14270
in subset: NCIthesaurus

endocrine pancreas disease
type: Class
subclass of: pancreas disease
imported from: doid.owl
has cross-reference: ICD10CM:E16
has cross-reference: ICD9CM:251
has cross-reference: SNOMEDCT_US_2020_03_01:190427005
has cross-reference: UMLS_CUI:C0154189
has_obo_namespace: disease_ontology
id: DOID:1428

primary hypertrophic osteoarthropathy
type: Class
subclass of: syndrome
imported from: doid.owl
has cross-reference: ICD10CM:M89.4
has cross-reference: MESH:D010004
has cross-reference: NCI:C85023
has cross-reference: OMIM:259100
has cross-reference: SNOMEDCT_US_2020_03_01:88220006
has cross-reference: UMLS_CUI:C0029411
alternative_term: Pachydermoperiostosis of nail
alternative_term: Pachydermoperiostosis syndrome
has_obo_namespace: disease_ontology
id: DOID:14283
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

patellofemoral pain syndrome
type: Class
subclass of: arthropathy
imported from: doid.owl
has cross-reference: MESH:D046788
has cross-reference: UMLS_CUI:C0877149
has_obo_namespace: disease_ontology
id: DOID:14284

Ebstein anomaly
type: Class
subclass of: tricuspid valve disease
textual definition: A tricuspid valve disease that is a congenital heart defect in which the septal leaflet of the tricuspid valve is displaced towards the apex of the right ventricle of the heart.
imported from: doid.owl
has cross-reference: GARD:6313
has cross-reference: ICD10CM:Q22.5
has cross-reference: ICD9CM:746.2
has cross-reference: MESH:D004437
has cross-reference: NCI:C84681
has cross-reference: OMIM:224700
has cross-reference: SNOMEDCT_US_2020_03_01:1796006
has cross-reference: UMLS_CUI:C0013481
alternative_term: Ebstein's anomaly
alternative_term: Ebstein's anomaly of common atrioventricular valve
alternative_term: Ebstein's anomaly of right atrioventricular valve
alternative_term: Ebstein's anomaly of tricuspid valve
has_obo_namespace: disease_ontology
id: DOID:14289
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Noonan syndrome with multiple lentigines
type: Class
subclass of: autosomal dominant disease
subclass of: RASopathy
textual definition: A RASopathy that is characterized by autosomal dominant inheritance of brown skin spots called lentigines that are similar to freckles, heart defects, widely spaced eyes a sunken chest or protruding chest and short stature.
imported from: doid.owl
has cross-reference: GARD:1100
has cross-reference: MESH:D044542
has cross-reference: NCI:C84820
has cross-reference: OMIM:PS151100
has cross-reference: ORDO:500
has cross-reference: SNOMEDCT_US_2020_03_01:111306001
has cross-reference: UMLS_CUI:C0175704
alternative_term: Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome
alternative_term: Generalized lentiginosis
alternative_term: Gorlin syndrome II
alternative_term: LEOPARD syndrome
alternative_term: Lentiginosis profusa syndrome
alternative_term: Moynahan syndrome
alternative_term: Multiple lentigines syndrome
alternative_term: Progressive cardiomyopathic lentiginosis
has_obo_namespace: disease_ontology
id: DOID:14291
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

tuberculous empyema
type: Class
subclass of: pleural empyema
textual definition: A pleural empyema which involves presence of pus in the pleural cavity and calcified visceral pleura. It results from a large number of mycobacteria spilling into the pleural space, usually from rupture of a cavity or an adjacent paranchymal focus via a bronchopleural fistula.
imported from: doid.owl
has cross-reference: MESH:D004654
has cross-reference: NCI:C34575
has cross-reference: SNOMEDCT_US_2020_03_01:186184002
has cross-reference: UMLS_CUI:C0014014
alternative_term: Tuberculous empyema
has_obo_namespace: disease_ontology
id: DOID:14305
in subset: NCIthesaurus

blindness
type: Class
subclass of: eye disease
textual definition: An eye disease characterized by a lack or loss of vision.
imported from: doid.owl
has cross-reference: ICD10CM:H54
has cross-reference: ICD9CM:369
has cross-reference: SNOMEDCT_US_2020_03_01:193698004
has cross-reference: UMLS_CUI:C0155020
alternative_term: vision impairment
alternative_term: vision loss
alternative_term: visual impairment
has_obo_namespace: disease_ontology
id: DOID:1432
in subset: DO FlyBase slim

generalized anxiety disorder
type: Class
subclass of: anxiety disorder
textual definition: An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.
imported from: doid.owl
has cross-reference: ICD10CM:F41.1
has cross-reference: ICD9CM:300.02
has cross-reference: NCI:C92622
has cross-reference: SNOMEDCT_US_2020_03_01:192401002
has cross-reference: UMLS_CUI:C0270549
has_obo_namespace: disease_ontology
id: DOID:14320
in subset: NCIthesaurus

Marfan syndrome
type: Class
subclass of: aortic disease
subclass of: eye disease
subclass of: connective tissue disease
textual definition: A connective tissue disease that is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens.
imported from: doid.owl
has cross-reference: GARD:6975
has cross-reference: ICD10CM:Q87.4
has cross-reference: ICD9CM:759.82
has cross-reference: MESH:D008382
has cross-reference: NCI:C34807
has cross-reference: OMIM:154700
has cross-reference: SNOMEDCT_US_2020_03_01:19346006
has cross-reference: UMLS_CUI:C0024796
alternative_term: Marfan's syndrome
has_obo_namespace: disease_ontology
id: DOID:14323
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mixed malaria
type: Class
subclass of: malaria
textual definition: A malaria that involves infection with more than one species of Plasmodium at the same time.
imported from: doid.owl
has cross-reference: ICD9CM:084.5
has cross-reference: SNOMEDCT_US_2020_03_01:21070001
has cross-reference: UMLS_CUI:C0153121
alternative_term: Malaria fever by more than one parasite
alternative_term: malaria by more than one parasite
has_obo_namespace: disease_ontology
id: DOID:14325

Parkinson's disease
type: Class
subclass of: synucleinopathy
textual definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
imported from: doid.owl
has cross-reference: EFO:0002508
has cross-reference: GARD:10251
has cross-reference: ICD10CM:G20
has cross-reference: ICD9CM:332
has cross-reference: KEGG:05012
has cross-reference: MESH:D010300
has cross-reference: NCI:C26845
has cross-reference: OMIM:PS168600
has cross-reference: ORDO:2828
has cross-reference: SNOMEDCT_US_2020_03_01:49049000
has cross-reference: UMLS_CUI:C0030567
alternative_term: Parkinson disease
alternative_term: paralysis agitans
has_obo_namespace: disease_ontology
id: DOID:14330
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

suppurative thyroiditis
type: Class
subclass of: thyroiditis
imported from: doid.owl
has cross-reference: ICD10CM:E06.0
has cross-reference: MESH:D013969
has cross-reference: NCI:C129724
has cross-reference: SNOMEDCT_US_2020_03_01:3511005
has cross-reference: UMLS_CUI:C0040150
alternative_term: Infectious thyroiditis
alternative_term: Suppurative thyroiditis
alternative_term: acute suppurative thyroiditis
has_obo_namespace: disease_ontology
id: DOID:14350
in subset: NCIthesaurus

corneal ectasia
type: Class
subclass of: corneal disease
imported from: doid.owl
has cross-reference: ICD10CM:H18.71
has cross-reference: ICD9CM:371.71
has cross-reference: SNOMEDCT_US_2020_03_01:14748007
has cross-reference: UMLS_CUI:C0155135
has_obo_namespace: disease_ontology
id: DOID:1436

systemic primary carnitine deficiency disease
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that involves defective proteins called carnitine transporters, which bring carnitine into cells and prevent its escape from the body preventing the body cannot utilize fats for energy.
imported from: doid.owl
has_alternative_id: DOID:1668
has cross-reference: ICD10CM:E71.41
has cross-reference: ICD9CM:277.81
has cross-reference: MESH:C536778
has cross-reference: NCI:C98864
has cross-reference: OMIM:212140
has cross-reference: SNOMEDCT_US_2020_03_01:21764004
has cross-reference: UMLS_CUI:C0342788
alternative_term: carnitine transporter deficiency
alternative_term: carnitine uptake defect
alternative_term: deficiency of plasma-membrane carnitine transporter
alternative_term: primary carnitine deficiency
alternative_term: renal carnitine transport defect
has_obo_namespace: disease_ontology
id: DOID:14365
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

norwegian scabies
type: Class
subclass of: scabies
textual definition: A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.
imported from: doid.owl
has cross-reference: NCI:C34855
has cross-reference: SNOMEDCT_US_2020_03_01:128870005
has cross-reference: UMLS_CUI:C0028425
alternative_term: Crusted scabies
has_obo_namespace: disease_ontology
id: DOID:14374
in subset: NCIthesaurus

pyuria
type: Class
subclass of: urinary system disease
imported from: doid.owl
has cross-reference: ICD10CM:R82.81
has cross-reference: MESH:D011776
has cross-reference: NCI:C119028
has cross-reference: SNOMEDCT_US_2020_03_01:4800001
has cross-reference: UMLS_CUI:C0034359
alternative_term: Pus cells in urine
has_obo_namespace: disease_ontology
id: DOID:1439
in subset: NCIthesaurus

Machado-Joseph disease
type: Class
subclass of: autosomal dominant cerebellar ataxia
textual definition: An autosomal dominant cerebellar ataxia that is characterized by slow degeneration of the hindbrain and has_material_basis_in expansion of CAG triplet repeats (glutamine) in the ATXN3 gene.
imported from: doid.owl
has cross-reference: MESH:D017827
has cross-reference: NCI:C84830
has cross-reference: OMIM:109150
has cross-reference: SNOMEDCT_US_2020_03_01:91952008
has cross-reference: UMLS_CUI:C0024408
alternative_term: Azorean disease
alternative_term: MJD
alternative_term: SCA3
alternative_term: spinocerebellar ataxia 3
alternative_term: spinocerebellar ataxia type 3
has_obo_namespace: disease_ontology
id: DOID:1440
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

capillary leak syndrome
type: Class
subclass of: capillary disease
imported from: doid.owl
has cross-reference: MESH:D019559
has cross-reference: NCI:C62578
has cross-reference: SNOMEDCT_US_2020_03_01:87730004
has cross-reference: UMLS_CUI:C0343084
alternative_term: Capillary leak syndrome
has_obo_namespace: disease_ontology
id: DOID:14400
in subset: NCIthesaurus

autosomal dominant cerebellar ataxia
type: Class
subclass of: autosomal dominant disease
subclass of: cerebellar ataxia
textual definition: A cerebellar ataxia that has_material_basis_in autosomal dominant inheritance.
imported from: doid.owl
has_alternative_id: DOID:2478
has cross-reference: MESH:D020754
has cross-reference: NCI:C82341
has cross-reference: OMIM:PS164400
has cross-reference: ORDO:94
has cross-reference: SNOMEDCT_US_2020_03_01:129609000
has cross-reference: UMLS_CUI:C0087012
alternative_term: spinocerebellar ataxia
has_obo_namespace: disease_ontology
id: DOID:1441
in subset: DO FlyBase slim
in subset: NCIthesaurus

Legg-Calve-Perthes disease
type: Class
subclass of: osteochondrosis
textual definition: An osteochondrosis that results_in death and fracture located_in hip joint.
imported from: doid.owl
has_alternative_id: DOID:14561
has cross-reference: GARD:6874
has cross-reference: ICD10CM:M91.2
has cross-reference: MESH:D007873
has cross-reference: NCI:C34766
has cross-reference: OMIM:150600
has cross-reference: SNOMEDCT_US_2020_03_01:15739006
has cross-reference: SNOMEDCT_US_2020_03_01:270545000
has cross-reference: UMLS_CUI:C0022441
has cross-reference: UMLS_CUI:C0023234
alternative_term: Calve - Perthes' disease
alternative_term: Coxa plana
alternative_term: Juvenile osteochond-hip/pelvis
alternative_term: Juvenile osteochondrosis of hip and/or pelvis
alternative_term: Perthe's disease
alternative_term: Perthes disease
alternative_term: Pseudocoxalgia
alternative_term: juvenile osteochondrosis of hip and pelvis
alternative_term: osteochondrosis of Legg-Calve-Perthes
alternative_term: pseudocoxalgia
has_obo_namespace: disease_ontology
has_related_synonym: Legg-Calve-Perthes symptom
id: DOID:14415
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

dracunculiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.
imported from: doid.owl
has cross-reference: GARD:6286
has cross-reference: ICD10CM:B72
has cross-reference: ICD9CM:125.7
has cross-reference: MESH:D004320
has cross-reference: NCI:C84677
has cross-reference: SNOMEDCT_US_2020_03_01:48874008
has cross-reference: UMLS_CUI:C0013100
alternative_term: Dracontiasis
alternative_term: Infection by Dracunculus medinensis
has_obo_namespace: disease_ontology
id: DOID:14418
in subset: NCIthesaurus

glossopharyngeal neuralgia
type: Class
subclass of: glossopharyngeal nerve disease
imported from: doid.owl
has cross-reference: GARD:6519
has cross-reference: ICD10CM:G52.1
has cross-reference: ICD9CM:352.1
has cross-reference: MESH:D020435
has cross-reference: SNOMEDCT_US_2020_03_01:43763009
has cross-reference: UMLS_CUI:C0154731
alternative_term: Glossopharyngeal neuralgia
has_obo_namespace: disease_ontology
id: DOID:14423

cerebral degeneration
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue.
imported from: doid.owl
has cross-reference: GARD:6019
has cross-reference: ICD9CM:331.9
has cross-reference: SNOMEDCT_US_2020_03_01:52522001
has cross-reference: UMLS_CUI:C0154671
alternative_term: Brain degeneration
has_obo_namespace: disease_ontology
id: DOID:1443

cholinergic urticaria
type: Class
subclass of: physical urticaria
textual definition: A physical urticaria induced by sweating.
imported from: doid.owl
has cross-reference: ICD10CM:L50.5
has cross-reference: ICD9CM:708.5
has cross-reference: SNOMEDCT_US_2020_03_01:73098005
has cross-reference: UMLS_CUI:C0152230
has_obo_namespace: disease_ontology
id: DOID:14443

sclerosing keratitis
type: Class
subclass of: DOID 9858
textual definition: A deep keratitis that is characterized by inflammation of the anterior sclera and subsequent inflammation of the adjacent cornea with opacification of the corneal stroma and has_symptom pain, red eyes, photophobia, tearing, and blurry vision. Sclerosing keratitis is caused by severe anterior scleritis that causes inflammation and injury to the adjacent corneal layer. Anterior scleritis can be caused by autoimmune diseases, connective tissue diseases, and infection.
imported from: doid.owl
has cross-reference: ICD10CM:H16.33
has cross-reference: ICD9CM:370.54
has cross-reference: SNOMEDCT_US_2020_03_01:27886001
has cross-reference: UMLS_CUI:C0155090
alternative_term: Sclerokeratitis
has_obo_namespace: disease_ontology
id: DOID:14444

gonadal dysgenesis
type: Class
subclass of: disorder of sexual development
textual definition: A disorder of sexual development that is characterized by a progressive loss of germ cells on the developing gonads of an embryo.
imported from: doid.owl
has cross-reference: GARD:2538
has cross-reference: ICD9CM:758.6
has cross-reference: MESH:D006059
has cross-reference: NCI:C61420
has cross-reference: SNOMEDCT_US_2020_03_01:268356004
has cross-reference: UMLS_CUI:C0018051
alternative_term: Gonadal dysgenesis syndrome
has_obo_namespace: disease_ontology
id: DOID:14447
in subset: NCIthesaurus

mixed gonadal dysgenesis
type: Class
subclass of: gonadal dysgenesis
textual definition: A gonadal dysgenesis that is characterized by progressive loss of primordial cells on the developing glands of an embryo, leading to extremely hypoplastic and dysfuctioning gonads resulting in one differentiated gonad and either a streak gonad or streak testis.
imported from: doid.owl
has cross-reference: MESH:D006060
has cross-reference: NCI:C120199
has cross-reference: SNOMEDCT_US_2020_03_01:205682006
has cross-reference: UMLS_CUI:C0018055
has_obo_namespace: disease_ontology
id: DOID:14449
in subset: NCIthesaurus

hyperkalemic periodic paralysis
type: Class
subclass of: familial periodic paralysis
imported from: doid.owl
has cross-reference: GARD:195
has cross-reference: ICD10CM:G72.3
has cross-reference: MESH:D020513
has cross-reference: NCI:C123429
has cross-reference: OMIM:170500
has cross-reference: ORDO:682
has cross-reference: SNOMEDCT_US_2020_03_01:304737009
has cross-reference: UMLS_CUI:C0238357
alternative_term: familial hyperkalemic periodic paralysis
has_obo_namespace: disease_ontology
id: DOID:14451
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hypokalemic periodic paralysis
type: Class
subclass of: familial periodic paralysis
imported from: doid.owl
has cross-reference: GARD:5557
has cross-reference: GARD:6729
has cross-reference: ICD10CM:G72.3
has cross-reference: MESH:D020514
has cross-reference: NCI:C84775
has cross-reference: OMIM:170400
has cross-reference: OMIM:613345
has cross-reference: ORDO:681
has cross-reference: SNOMEDCT_US_2020_03_01:240093008
has cross-reference: UMLS_CUI:C0238358
alternative_term: Hypokalemic familial periodic paralysis
alternative_term: Hypokalemic periodic paralysis
alternative_term: Periodic paralysis I
alternative_term: Westphal disease
alternative_term: familial hypokalemic periodic paralysis
alternative_term: familial periodic paralysis
alternative_term: periodic hypokalemic paralysis
has_obo_namespace: disease_ontology
id: DOID:14452
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

farmer's lung
type: Class
subclass of: extrinsic allergic alveolitis
textual definition: An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.
imported from: doid.owl
has cross-reference: GARD:6427
has cross-reference: ICD10CM:J67.0
has cross-reference: ICD9CM:495.0
has cross-reference: MESH:D005203
has cross-reference: NCI:C34605
has cross-reference: SNOMEDCT_US_2020_03_01:155581001
has cross-reference: UMLS_CUI:C0015634
alternative_term: Farmers lung
alternative_term: farmer lung
has_obo_namespace: disease_ontology
id: DOID:14453
in subset: NCIthesaurus

neuroleptic malignant syndrome
type: Class
subclass of: DOID 863
textual definition: A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers.
imported from: doid.owl
has cross-reference: GARD:7195
has cross-reference: ICD10CM:G21.0
has cross-reference: ICD9CM:333.92
has cross-reference: MESH:D009459
has cross-reference: NCI:C94829
has cross-reference: ORDO:94093
has cross-reference: SNOMEDCT_US_2020_03_01:15244003
has cross-reference: UMLS_CUI:C0027849
has_obo_namespace: disease_ontology
id: DOID:14464
in subset: DO rare slim
in subset: NCIthesaurus

hantavirus pulmonary syndrome
type: Class
subclass of: lung disease
subclass of: DOID 934
textual definition: A viral infectious disease that results in infection located in lung, has_material_basis_in Sin Nombre virus, transmitted by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted by rice rat (Oligoryzomys longicaudatus). The infection has _ymptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.
imported from: doid.owl
has cross-reference: GARD:69
has cross-reference: MESH:D018804
has cross-reference: NCI:C84747
has cross-reference: SNOMEDCT_US_2020_03_01:120639003
has cross-reference: UMLS_CUI:C0243025
has_obo_namespace: disease_ontology
id: DOID:14472
in subset: NCIthesaurus
in subset: zoonotic infectious disease

pemphigoid gestationis
type: Class
subclass of: autoimmune disease of skin and connective tissue
subclass of: vesiculobullous skin disease
textual definition: A vesiculobullous skin disease that is characterized by erythematous papules, vesicles, and plaques around the trunk and extremities that develop during pregnancy, particularly during the second and third trimesters, has_symptom pruritis, and has_material_basis_in autoantibodies to the basement membrane, which triggers a complement cascade and attracts eosinophils to the subepidermis.
imported from: doid.owl
has cross-reference: ICD10CM:O26.4
has cross-reference: MESH:D006559
has cross-reference: NCI:C85003
has cross-reference: SNOMEDCT_US_2020_03_01:86081009
has cross-reference: UMLS_CUI:C0019343
alternative_term: Gestational herpes
alternative_term: herpes gestationis
has_obo_namespace: disease_ontology
id: DOID:14482
in subset: NCIthesaurus

sporotrichosis
type: Class
subclass of: primary systemic mycosis
textual definition: A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation.
imported from: doid.owl
has cross-reference: GARD:7692
has cross-reference: ICD10CM:B42
has cross-reference: ICD9CM:117.1
has cross-reference: MESH:D013174
has cross-reference: SNOMEDCT_US_2020_03_01:266218008
has cross-reference: UMLS_CUI:C0038034
has_obo_namespace: disease_ontology
id: DOID:14484

dumping syndrome
type: Class
subclass of: postgastrectomy syndrome
imported from: doid.owl
has cross-reference: ICD10CM:K91.1
has cross-reference: MESH:D004377
has cross-reference: NCI:C2994
has cross-reference: SNOMEDCT_US_2020_03_01:155785007
has cross-reference: UMLS_CUI:C0013288
alternative_term: Dumping (jejunal) syndrome
alternative_term: Jejunal syndrome
has_obo_namespace: disease_ontology
id: DOID:14495
in subset: NCIthesaurus

Wolman disease
type: Class
subclass of: lysosomal and lipase deficiency
imported from: doid.owl
has cross-reference: GARD:7899
has cross-reference: ICD10CM:E75.5
has cross-reference: MESH:D015223
has cross-reference: NCI:C61271
has cross-reference: SNOMEDCT_US_2020_03_01:82500001
has cross-reference: UMLS_CUI:C0043208
alternative_term: Acid esterase deficiency
alternative_term: Acid lipase deficiency
alternative_term: Wolman xanthomatosis
alternative_term: Wolman's disease
alternative_term: Wolman's or triglyceride storage type III disease
alternative_term: Xanthomatosis, familial
has_obo_namespace: disease_ontology
id: DOID:14497
in subset: NCIthesaurus

lipoid proteinosis
type: Class
subclass of: lipid metabolism disorder
imported from: doid.owl
has cross-reference: GARD:3268
has cross-reference: MESH:D008065
has cross-reference: NCI:C84829
has cross-reference: OMIM:247100
has cross-reference: SNOMEDCT_US_2020_03_01:38692000
has cross-reference: UMLS_CUI:C0023795
alternative_term: Lipid proteinosis
alternative_term: Lipoid proteinosis
alternative_term: URBACH-WIETHE DISEASE
has_obo_namespace: disease_ontology
id: DOID:14498
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Fabry disease
type: Class
subclass of: sphingolipidosis
textual definition: A sphingolipidosis that is characterized by the buildup of globotriaosylceramide in the body's cells and has_material_basis_in X-linked inherited mutations in the GLA gene, encoding alpha-galactosidase A, on chromosome Xq22.
imported from: doid.owl
has cross-reference: GARD:6400
has cross-reference: ICD10CM:E75.21
has cross-reference: MESH:D000795
has cross-reference: NCI:C84701
has cross-reference: OMIM:301500
has cross-reference: SNOMEDCT_US_2020_03_01:16652001
has cross-reference: UMLS_CUI:C0002986
alternative_term: Alpha-galactosidase A deficiency
alternative_term: Angiokeratoma Corporis Diffusum
alternative_term: Fabry's disease
alternative_term: alpha galactosidase deficiency
alternative_term: deficiency of melibiase
has_obo_namespace: disease_ontology
id: DOID:14499
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

fucosidosis
type: Class
subclass of: lysosomal storage disease
imported from: doid.owl
has cross-reference: GARD:6473
has cross-reference: ICD10CM:E77.1
has cross-reference: MESH:D005645
has cross-reference: NCI:C61274
has cross-reference: OMIM:230000
has cross-reference: SNOMEDCT_US_2020_03_01:64716005
has cross-reference: UMLS_CUI:C0016788
alternative_term: A-fucosidase deficiency
alternative_term: alpha fucosidase deficiency
has_obo_namespace: disease_ontology
id: DOID:14500
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cholesterol ester storage disease
type: Class
subclass of: lysosomal and lipase deficiency
imported from: doid.owl
has cross-reference: MESH:D015217
has cross-reference: SNOMEDCT_US_2020_03_01:57218003
has cross-reference: UMLS_CUI:C0008384
has_obo_namespace: disease_ontology
id: DOID:14502

neuronal ceroid lipofuscinosis
type: Class
subclass of: DOID 9455
imported from: doid.owl
has cross-reference: GARD:10739
has cross-reference: ICD10CM:E75.4
has cross-reference: MESH:D009472
has cross-reference: NCI:C61257
has cross-reference: OMIM:PS256730
has cross-reference: ORDO:216
has cross-reference: ORDO:79262
has cross-reference: SNOMEDCT_US_2020_03_01:42012007
has cross-reference: UMLS_CUI:C0027877
alternative_term: hereditary ceroid lipofuscinosis
has_obo_namespace: disease_ontology
id: DOID:14503
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS].

Niemann-Pick disease
type: Class
subclass of: sphingolipidosis
textual definition: A sphingoliidosis characterized by the accumulation of the lipid sphingomyelin in lysosomes in cells.
imported from: doid.owl
has_alternative_id: DOID:0050442
has_alternative_id: DOID:0050443
has_alternative_id: DOID:14770
has cross-reference: GARD:13334
has cross-reference: ICD10CM:E75.24
has cross-reference: MESH:D009542
has cross-reference: NCI:C61269
has cross-reference: SNOMEDCT_US_2020_03_01:58459009
has cross-reference: UMLS_CUI:C0028064
alternative_term: Sphingomyelinase Deficiency Disease
alternative_term: lipoid histiocytosis
alternative_term: sphingomyelin lipidosis
has_obo_namespace: disease_ontology
id: DOID:14504
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

WAGR syndrome
type: Class
subclass of: chromosomal deletion syndrome
textual definition: A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.
imported from: doid.owl
has cross-reference: GARD:5528
has cross-reference: MESH:D017624
has cross-reference: NCI:C3718
has cross-reference: OMIM:194072
has cross-reference: SNOMEDCT_US_2020_03_01:715215007
has cross-reference: UMLS_CUI:C0206115
alternative_term: 11p partial monosomy syndrome
alternative_term: Wilms tumor-Aniridia-Genitourinary Anomalies-Mental Retardation syndrome
alternative_term: chromosome 11p13 deletion syndrome
has_obo_namespace: disease_ontology
id: DOID:14515
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

Reye syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use.
imported from: doid.owl
has cross-reference: GARD:7570
has cross-reference: ICD10CM:G93.7
has cross-reference: ICD9CM:331.81
has cross-reference: MESH:D012202
has cross-reference: NCI:C34983
has cross-reference: SNOMEDCT_US_2020_03_01:74351001
has cross-reference: UMLS_CUI:C0035400
alternative_term: Reye's syndrome
has_obo_namespace: disease_ontology
id: DOID:14525
in subset: NCIthesaurus

root resorption
type: Class
subclass of: tooth resorption
imported from: doid.owl
has cross-reference: MESH:D012391
has cross-reference: UMLS_CUI:C0035851
has_obo_namespace: disease_ontology
id: DOID:14550

primary pulmonary hypertension
type: Class
subclass of: chronic pulmonary heart disease
textual definition: A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling.
imported from: doid.owl
has cross-reference: ICD10CM:I27.0
has cross-reference: ICD9CM:416.0
has cross-reference: NCI:C97119
has cross-reference: OMIM:178600
has cross-reference: OMIM:265400
has cross-reference: OMIM:615342
has cross-reference: OMIM:615343
has cross-reference: OMIM:615344
has cross-reference: ORDO:422
has cross-reference: SNOMEDCT_US_2020_03_01:26174007
has cross-reference: UMLS_CUI:C0152171
has_obo_namespace: disease_ontology
id: DOID:14557
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

glossitis
type: Class
subclass of: tongue disease
imported from: doid.owl
has cross-reference: ICD10CM:K14.0
has cross-reference: ICD9CM:529.0
has cross-reference: MESH:D005928
has cross-reference: NCI:C112199
has cross-reference: SNOMEDCT_US_2020_03_01:155666003
has cross-reference: UMLS_CUI:C0017675
has_obo_namespace: disease_ontology
id: DOID:1456
in subset: NCIthesaurus

disease of cellular proliferation
type: Class
subclass of: disease
textual definition: A disease that is characterized by abnormally rapid cell division.
imported from: doid.owl
IEDB alternative term: neoplasm
has_alternative_id: DOID:0000818
alternative_term: cell process disease
alternative_term: neoplasm
has_obo_namespace: disease_ontology
id: DOID:14566
in subset: DO FlyBase slim

hypothyroidism
type: Class
subclass of: thyroid gland disease
textual definition: A thyroid gland disease which involves an underproduction of thyroid hormone.
imported from: doid.owl
has_alternative_id: DOID:11630
has cross-reference: EFO:0004705
has cross-reference: ICD10CM:E03.9
has cross-reference: ICD9CM:244.9
has cross-reference: MESH:D007037
has cross-reference: NCI:C26800
has cross-reference: SNOMEDCT_US_2020_03_01:267465007
has cross-reference: UMLS_CUI:C0020676
alternative_term: Thyroid deficiency
alternative_term: Thyroid insufficiency
has_obo_namespace: disease_ontology
id: DOID:1459
in subset: NCIthesaurus

papilledema
type: Class
subclass of: optic nerve disease
imported from: doid.owl
has cross-reference: GARD:7318
has cross-reference: ICD10CM:H47.1
has cross-reference: ICD9CM:377.0
has cross-reference: MESH:D010211
has cross-reference: NCI:C3307
has cross-reference: SNOMEDCT_US_2020_03_01:423341008
has cross-reference: UMLS_CUI:C0030353
has_obo_namespace: disease_ontology
id: DOID:146
in subset: NCIthesaurus

prostatitis
type: Class
subclass of: prostate disease
imported from: doid.owl
has cross-reference: ICD10CM:N41.9
has cross-reference: ICD9CM:601.9
has cross-reference: MESH:D011472
has cross-reference: NCI:C26866
has cross-reference: SNOMEDCT_US_2020_03_01:155907007
has cross-reference: UMLS_CUI:C0033581
has_obo_namespace: disease_ontology
id: DOID:14654
in subset: NCIthesaurus

acrodysostosis
type: Class
subclass of: dysostosis
textual definition: A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.
imported from: doid.owl
has cross-reference: GARD:2015
has cross-reference: GARD:5724
has cross-reference: MESH:C538179
has cross-reference: OMIM:101800
has cross-reference: OMIM:614613
has cross-reference: ORDO:950
has cross-reference: SNOMEDCT_US_2020_03_01:66758006
has cross-reference: UMLS_CUI:C0220659
has_obo_namespace: disease_ontology
id: DOID:14669
comment: OMIM mapping confirmed by DO. [SN].

multiple intestinal atresia
type: Class
subclass of: autosomal recessive disease
subclass of: intestinal disease
textual definition: An intestinal disease characterized by the presence of numerous atresic segments in the small and large intestines that has_material_basis_in homozygous or compound heterozygous mutation in TTC7A on chromosome 2p21.
imported from: doid.owl
has cross-reference: GARD:3013
has cross-reference: MESH:C562441
has cross-reference: OMIM:243150
has cross-reference: ORDO:2300
has cross-reference: SNOMEDCT_US_2020_03_01:95472001
has cross-reference: UMLS_CUI:C0220744
alternative_term: GIDID
alternative_term: MEDDRA:10028210
alternative_term: Multiple gastrointestinal atresias
alternative_term: familial intestinal polyatresia syndrome
alternative_term: gastrointestinal defects and immunodeficiency syndrome
has_obo_namespace: disease_ontology
id: DOID:14671
comment: OMIM mapping confirmed by DO. [SN].

VACTERL association
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities.
imported from: doid.owl
has cross-reference: GARD:5443
has cross-reference: ICD10CM:Q87.2
has cross-reference: MESH:C536534
has cross-reference: OMIM:192350
has cross-reference: OMIM:276950
has cross-reference: SNOMEDCT_US_2020_03_01:205830006
has cross-reference: UMLS_CUI:C0220708
has_obo_namespace: disease_ontology
has_related_synonym: VATER syndrome
id: DOID:14679
comment: OMIM mapping confirmed by DO. [LS].

labyrinthitis
type: Class
subclass of: otitis interna
textual definition: An otitis interna which involves inflammation of the labyrinths.
imported from: doid.owl
has cross-reference: ICD10CM:H83.0
has cross-reference: ICD9CM:386.3
has cross-reference: MESH:D007762
has cross-reference: SNOMEDCT_US_2020_03_01:155239008
has cross-reference: UMLS_CUI:C0022893
has_obo_namespace: disease_ontology
id: DOID:1468

Silver-Russell syndrome
type: Class
subclass of: physical disorder
textual definition: A physical disorder that is characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
imported from: doid.owl
has cross-reference: GARD:4870
has cross-reference: ICD10CM:Q87.19
has cross-reference: MESH:D056730
has cross-reference: NCI:C85068
has cross-reference: OMIM:180860
has cross-reference: SNOMEDCT_US_2020_03_01:15069006
has cross-reference: UMLS_CUI:C0175693
alternative_term: Silver Russell Dwarfism
has_obo_namespace: disease_ontology
id: DOID:14681
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

Axenfeld-Rieger syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: eye disease
textual definition: An eye disease characterized by abnormalities of the front part of the eye, the anterior segment.
imported from: doid.owl
has cross-reference: GARD:5701
has cross-reference: ICD10CM:Q13.81
has cross-reference: NCI:C131001
has cross-reference: ORDO:782
has cross-reference: SNOMEDCT_US_2020_03_01:47507006
has cross-reference: UMLS_CUI:C0265341
alternative_term: Anomaly, Rieger's
alternative_term: Axenfeld syndrome
alternative_term: RGS - Rieger syndrome
alternative_term: Rieger's anomaly
has_obo_namespace: disease_ontology
has_related_synonym: Hagedoom syndrome
id: DOID:14686
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

diastrophic dysplasia
type: Class
subclass of: autosomal recessive disease
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism.
imported from: doid.owl
has cross-reference: GARD:6275
has cross-reference: ICD10CM:Q77.5
has cross-reference: MESH:C536170
has cross-reference: NCI:C156311
has cross-reference: OMIM:222600
has cross-reference: SNOMEDCT_US_2020_03_01:58561002
has cross-reference: UMLS_CUI:C0220726
has_obo_namespace: disease_ontology
id: DOID:14687
comment: OMIM mapping confirmed by DO. [SN].

Smith-Lemli-Opitz syndrome
type: Class
subclass of: lipid metabolism disorder
imported from: doid.owl
has_alternative_id: DOID:4366
has cross-reference: GARD:5683
has cross-reference: ICD10CM:E78.72
has cross-reference: MESH:D019082
has cross-reference: NCI:C85071
has cross-reference: OMIM:270400
has cross-reference: SNOMEDCT_US_2020_03_01:43929004
has cross-reference: UMLS_CUI:C0175694
alternative_term: Rutledge lethal multiple congenital anomaly syndrome
alternative_term: Smith-Opitz-Inborn syndrome
has_obo_namespace: disease_ontology
id: DOID:14692
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

Clouston syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: ectodermal dysplasia
imported from: doid.owl
has cross-reference: GARD:2056
has cross-reference: MESH:D004476
has cross-reference: OMIM:129500
has cross-reference: SNOMEDCT_US_2020_03_01:54209007
has cross-reference: UMLS_CUI:C0162361
alternative_term: Clouston's hidrotic ectodermal dysplasia
alternative_term: Clouston's syndrome
alternative_term: Hidrotic ectodermal dysplasia syndrome
alternative_term: ectodermal dysplasia 2, Clouston type
alternative_term: hidrotic ectodermal dysplasia
has_obo_namespace: disease_ontology
id: DOID:14693
comment: OMIM mapping confirmed by DO. [SN].

Johanson-Blizzard syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that involves abnormal development of the pancreas, nose and scalp, with mental retardation, hearing loss and growth failure. It is inherited in an autosomal recessive manner.
imported from: doid.owl
has cross-reference: GARD:80
has cross-reference: MESH:C535880
has cross-reference: OMIM:243800
has cross-reference: ORDO:2315
has cross-reference: SNOMEDCT_US_2020_03_01:75979009
has cross-reference: UMLS_CUI:C0175692
alternative_term: JBS
has_obo_namespace: disease_ontology
id: DOID:14694
comment: OMIM mapping confirmed by DO. [SN].

galactokinase deficiency
type: Class
subclass of: DOID 9870
textual definition: A galactosemia that involves an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase.
imported from: doid.owl
has cross-reference: GARD:2422
has cross-reference: ICD10CM:E74.29
has cross-reference: MESH:D005693
has cross-reference: NCI:C114767
has cross-reference: OMIM:230200
has cross-reference: SNOMEDCT_US_2020_03_01:124302001
has cross-reference: UMLS_CUI:C0268155
alternative_term: Galactosemia II
has_obo_namespace: disease_ontology
id: DOID:14695
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

thrombocytopenia-absent radius syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: chromosomal deletion syndrome
subclass of: syndrome
textual definition: A chromosomal deletion syndrome that is characterized by absence of the radius bone and platelet deficiency and bilateral absence of the radii with the presence of both thumbs and generally transient thrombocytopenia (less than 50 platelets/nL) and that has_material_basis_in compound heterozygosity for a rare null mutation involving the RBM8A gene on chromosome 1q12 on 1 allele and 1 of 2 low-frequency noncoding single-nucleotide polymorphisms in RBM8A on the other.
imported from: doid.owl
has cross-reference: ICD10CM:Q87.2
has cross-reference: MESH:C536940
has cross-reference: NCI:C99038
has cross-reference: OMIM:274000
has cross-reference: ORDO:3320
has cross-reference: SNOMEDCT_US_2020_03_01:85589009
has cross-reference: UMLS_CUI:C0175703
alternative_term: Radial aplasia-thrombocytopenia syndrome
alternative_term: Thrombocytopenia with absent radii (TAR) syndrome
alternative_term: chromosome 1q21.1 deletion syndrome
has_obo_namespace: disease_ontology
id: DOID:14699
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

major depressive disorder
type: Class
subclass of: mental depression
textual definition: An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.
imported from: doid.owl
has_alternative_id: DOID:10614
has_alternative_id: DOID:2240
has_alternative_id: DOID:2241
has_alternative_id: DOID:7580
has cross-reference: ICD10CM:F32
has cross-reference: ICD10CM:F33.9
has cross-reference: ICD9CM:296.2
has cross-reference: ICD9CM:296.3
has cross-reference: NCI:C34796
has cross-reference: OMIM:608520
has cross-reference: OMIM:608691
has cross-reference: SNOMEDCT_US_2020_03_01:268621008
has cross-reference: SNOMEDCT_US_2020_03_01:36923009
has cross-reference: UMLS_CUI:C0024517
has cross-reference: UMLS_CUI:C0154409
alternative_term: recurrent major depression
alternative_term: single major depressive episode
has_obo_namespace: disease_ontology
id: DOID:1470
in subset: NCIthesaurus
comment: Xref MGI.

propionic acidemia
type: Class
subclass of: organic acidemia
textual definition: An organic acidemia that involes a nonfunctional propionyl CoA carboxylase affecting conversion of aminio acids and fats into sugar for energy.
imported from: doid.owl
has_alternative_id: DOID:14706
has cross-reference: GARD:467
has cross-reference: ICD10CM:E71.121
has cross-reference: MESH:D056693
has cross-reference: NCI:C85030
has cross-reference: OMIM:606054
has cross-reference: SNOMEDCT_US_2020_03_01:69080001
has cross-reference: UMLS_CUI:C0268579
has cross-reference: UMLS_CUI:C2717876
alternative_term: GLYCINEMIA, KETOTIC
alternative_term: KETOTIC HYPERGLYCINEMIA
alternative_term: ketotic II glycinemia
alternative_term: ketotic glycinemia
alternative_term: propionic aciduria
alternative_term: propionyl-CoA carboxylase deficiency
has_obo_namespace: disease_ontology
id: DOID:14701
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

branchiootorenal syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome characterized by branchial arch anomalies (branchial fistulas, clefts, or cysts), hearing impairment, structural defects of the outer, middle, and inner ear, and renal abnormalities.
imported from: doid.owl
has cross-reference: GARD:10147
has cross-reference: MEDDRA:10071135
has cross-reference: MESH:D019280
has cross-reference: NCI:C98983
has cross-reference: SNOMEDCT_US_2020_03_01:290006
has cross-reference: UMLS_CUI:C0265234
alternative_term: Branchio-Oto-renal syndrome
alternative_term: Branchio-otorenal dysplasia
alternative_term: Melnick-Fraser syndrome
alternative_term: branchiootorenal dysplasia
has_obo_namespace: disease_ontology
id: DOID:14702
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

FG syndrome
type: Class
subclass of: X-linked recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern.
imported from: doid.owl
has cross-reference: GARD:2317
has cross-reference: MESH:C537923
has cross-reference: OMIM:300321
has cross-reference: OMIM:300406
has cross-reference: OMIM:300422
has cross-reference: OMIM:300581
has cross-reference: OMIM:305450
has cross-reference: ORDO:323
has cross-reference: ORDO:93932
has cross-reference: SNOMEDCT_US_2020_03_01:49984004
has cross-reference: UMLS_CUI:C0220769
alternative_term: Keller syndrome
alternative_term: Opitz-Kaveggia syndrome
has_obo_namespace: disease_ontology
id: DOID:14711
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

centronuclear myopathy
type: Class
subclass of: myopathy
textual definition: A myopathy characterized by abnormally located nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery.
imported from: doid.owl
has cross-reference: GARD:101
has cross-reference: MESH:D020914
has cross-reference: NCI:C84648
has cross-reference: ORDO:595
has cross-reference: ORDO:596
has cross-reference: ORDO:69186
has cross-reference: ORDO:69189
has cross-reference: SNOMEDCT_US_2020_03_01:193223007
has cross-reference: UMLS_CUI:C0175709
alternative_term: myotubular myopathy
has_obo_namespace: disease_ontology
id: DOID:14717
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

beta-ketothiolase deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder characterized by inability to process isoleucine and ketones, has_symptom recurrent ketoacidotic attacks in infancy marked by vomitting, lethargy, dehydration, and seizures, and has_material_basis_in mutation in the ACAT1 gene of chromosome 11q22.3 responsible for producing the ACAT1 enzyme in mitochondria, which processes isoleucine and ketones.
imported from: doid.owl
has cross-reference: GARD:872
has cross-reference: MESH:C535818
has cross-reference: OMIM:203750
has cross-reference: ORDO:134
has cross-reference: SNOMEDCT_US_2020_03_01:238067002
has cross-reference: UMLS_CUI:C1533628
alternative_term: 2-methyl-3-hydroxybutyricacidemia
alternative_term: 3-ketothiolase deficiency
alternative_term: 3-oxothiolase deficiency
alternative_term: Mitochondrial acetoacetyl-CoA Thiolase deficiency
alternative_term: alpha-methylacetoaceticaciduria
alternative_term: peroxisomal thiolase deficiency
has_obo_namespace: disease_ontology
id: DOID:14723
comment: OMIM mapping confirmed by DO. [SN].

autosomal dominant microcephaly
type: Class
subclass of: autosomal dominant disease
subclass of: microcephaly
textual definition: A microcephaly that has_material_basis_in heterozygous mutation in an autosomal gene.
imported from: doid.owl
has cross-reference: MESH:C537323
has cross-reference: OMIM:156580
has cross-reference: UMLS_CUI:C0220693
has_obo_namespace: disease_ontology
id: DOID:14725
comment: OMIM mapping confirmed by DO. [SN].

Weaver syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by prenatal and postnatal overgrowth, accelerated osseous maturation, characteristic craniofacial appearance, and developmental delay and has_material_basis_in heterozygous mutation in the EZH2 gene on chromosome 7q36.
imported from: doid.owl
has cross-reference: GARD:5545
has cross-reference: GARD:7878
has cross-reference: MESH:C562443
has cross-reference: OMIM:277590
has cross-reference: UMLS_CUI:C0220765
alternative_term: WEAVER-LIKE SYNDROME
alternative_term: Weaver-Williams syndrome
has_obo_namespace: disease_ontology
id: DOID:14731
comment: OMIM mapping confirmed by DO. [LS].

craniofrontonasal syndrome
type: Class
subclass of: X-linked dominant disease
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in mutation in the EFNB1 gene on chromosome Xq13 and is characterized in hemizygous males by hypertelorism and with greater severity in females by frontonasal dysplasia, craniofacial asymmetry, craniosynostosis, bifid nasal tip, grooved nails, wiry hair, and abnormalities of the thoracic skeleton.
imported from: doid.owl
has cross-reference: GARD:1578
has cross-reference: MESH:C536456
has cross-reference: OMIM:304110
has cross-reference: ORDO:1520
has cross-reference: SNOMEDCT_US_2020_03_01:715421009
has cross-reference: UMLS_CUI:C0220767
alternative_term: CFND
alternative_term: CFNS
alternative_term: craniofrontonasal dysostosis
alternative_term: craniofrontonasal dysplasia
has_obo_namespace: disease_ontology
id: DOID:14737
comment: OMIM mapping confirmed by DO. [SN].

aggressive periodontitis
type: Class
subclass of: periodontitis
textual definition: A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.
imported from: doid.owl
has cross-reference: ICD10CM:K05.2
has cross-reference: MESH:D010520
has cross-reference: OMIM:170650
has cross-reference: OMIM:608526
has cross-reference: SNOMEDCT_US_2020_03_01:449908004
has cross-reference: UMLS_CUI:C0031106
alternative_term: juvenile periodontitis
has_obo_namespace: disease_ontology
id: DOID:1474
comment: OMIM mapping confirmed by DO. [SN].

trichorhinophalangeal syndrome type I
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by short stature, sparse hair, a bulbous nasal tip and cone-shaped epiphyses (the growing ends of bones), as well as severe generalized shortening of all finger and toe bones (brachydactyly).
imported from: doid.owl
has_alternative_id: DOID:0050552
has cross-reference: MESH:C536820
has cross-reference: NCI:C75109
has cross-reference: OMIM:190350
has cross-reference: SNOMEDCT_US_2020_03_01:239016009
has cross-reference: UMLS_CUI:C0432233
alternative_term: trichorhinophalangeal syndrome type 1
alternative_term: type I trichorhinophalangeal syndrome
has_obo_namespace: disease_ontology
has_related_synonym: Trichorhinophalangeal dysplasia type I
id: DOID:14743
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

Partington syndrome
type: Class
subclass of: syndromic X-linked intellectual disability
subclass of: X-linked recessive disease
textual definition: A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria.
imported from: doid.owl
has cross-reference: GARD:4235
has cross-reference: MESH:C562446
has cross-reference: OMIM:309510
has cross-reference: ORDO:94083
has cross-reference: UMLS_CUI:C0220775
alternative_term: X-linked Russell-Silver syndrome
has_obo_namespace: disease_ontology
id: DOID:14744
in subset: DO rare slim
comment: OMIM mapping confirmed by DO. [SN]. OMIM mapping submitted by NeuroDevNet. [LS].

Sotos syndrome
type: Class
subclass of: autosomal genetic disease
subclass of: syndrome
textual definition: A syndrome that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life.
imported from: doid.owl
has cross-reference: GARD:10091
has cross-reference: ICD10CM:Q87.3
has cross-reference: MESH:D058495
has cross-reference: NCI:C75019
has cross-reference: OMIM:PS117550
has cross-reference: ORDO:821
has cross-reference: SNOMEDCT_US_2020_03_01:75968004
has cross-reference: UMLS_CUI:C0175695
alternative_term: cerebral gigantism
has_obo_namespace: disease_ontology
id: DOID:14748
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

methylmalonic acidemia
type: Class
subclass of: organic acidemia
textual definition: An organic acidemia that involves an accumulation of methylmalonic acid in the blood.
imported from: doid.owl
has_alternative_id: DOID:14782
has_alternative_id: DOID:14802
has cross-reference: GARD:7033
alternative_term: methylmalonic aciduria
has_obo_namespace: disease_ontology
id: DOID:14749
comment: OMIM mapping confirmed by DO. [SN].

lymphangioma
type: Class
subclass of: benign vascular tumor
textual definition: A benign vascular tumor that is composed of dilated lymphatic channels.
imported from: doid.owl
has cross-reference: GARD:9789
has cross-reference: ICD10CM:D18.1
has cross-reference: ICD9CM:228.1
has cross-reference: MESH:D008202
has cross-reference: NCI:C8965
has cross-reference: SNOMEDCT_US_2020_03_01:154625006
has cross-reference: UMLS_CUI:C0024221
alternative_term: Congenital lymphangioma
alternative_term: benign lymphangioma
has_obo_namespace: disease_ontology
id: DOID:1475
in subset: NCIthesaurus

isovaleric acidemia
type: Class
subclass of: organic acidemia
textual definition: An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine.
imported from: doid.owl
has cross-reference: GARD:465
has cross-reference: ICD10CM:E71.110
has cross-reference: MESH:C538167
has cross-reference: NCI:C98964
has cross-reference: OMIM:243500
has cross-reference: SNOMEDCT_US_2020_03_01:87827003
has cross-reference: UMLS_CUI:C0268575
alternative_term: Isovaleryl-CoA dehydrogenase deficiency
alternative_term: isovaleric acid CoA dehydrogenase deficiency
alternative_term: isovaleric aciduria
has_obo_namespace: disease_ontology
id: DOID:14753
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

argininosuccinic aciduria
type: Class
subclass of: DOID 9252
textual definition: An amino acid metabolic disorder that involves the accumulation of argininosuccinic acid (ASA) in the blood and urine.
imported from: doid.owl
has cross-reference: GARD:5843
has cross-reference: MESH:D056807
has cross-reference: NCI:C84569
has cross-reference: OMIM:207900
has cross-reference: SNOMEDCT_US_2020_03_01:41013004
has cross-reference: UMLS_CUI:C0268547
alternative_term: Argininosuccinate lyase deficiency
alternative_term: argininosuccinic acidemia
alternative_term: arginosuccinase deficiency
alternative_term: deficiency of argininosuccinate lyase
has_obo_namespace: disease_ontology
id: DOID:14755
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

calcaneonavicular coalition
type: Class
subclass of: synostosis
textual definition: A synostosis characterized by the fusion of carpal and tarsal bones, which causes stiffness and immobility of the hands and the feet.
imported from: doid.owl
has cross-reference: OMIM:186400
has cross-reference: SNOMEDCT_US_2020_03_01:62628008
has cross-reference: UMLS_CUI:C0175700
alternative_term: Multiple synostosis syndrome
alternative_term: SYNOSTOSES, TARSAL, CARPAL AND DIGITAL
has_obo_namespace: disease_ontology
id: DOID:14762
comment: OMIM mapping confirmed by DO. [LS].

Larsen syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: Asyndrome that is characterized by autosomal dominant inheritance of large-joint dislocations and characteristic craniofacial abnormalities.
imported from: doid.owl
has cross-reference: GARD:6860
has cross-reference: OMIM:150250
alternative_term: dominant larsen syndrome
has_obo_namespace: disease_ontology
id: DOID:14764
comment: OMIM mapping confirmed by DO. [SN].

renal agenesis
type: Class
subclass of: kidney disease
textual definition: A renal disease that is characterized by the failure of one or both kidneys to develop.
imported from: doid.owl
has cross-reference: GARD:9228
has cross-reference: OMIM:191830
has cross-reference: ORDO:93108
alternative_term: hereditary renal aplasia
alternative_term: hereditary urogenital adysplasia
alternative_term: renal adysplasia
alternative_term: renal aplasia
has_obo_namespace: disease_ontology
id: DOID:14766

cartilage-hair hypoplasia
type: Class
subclass of: autosomal recessive disease
subclass of: ectodermal dysplasia
textual definition: An ectodermal dysplasia characterized by short-limbed short stature and fine, sparse hair that has_material_basis_in homozygous or compound heterozygous mutation in RMRP on chromosome 9p13.3.
imported from: doid.owl
has_alternative_id: DOID:0080022
has cross-reference: MESH:C535916
has cross-reference: NCI:C61245
has cross-reference: OMIM:250250
has cross-reference: SNOMEDCT_US_2020_03_01:234421004
has cross-reference: UMLS_CUI:C0220748
alternative_term: CHH
alternative_term: McKusick type metaphyseal chondrodysplasia
alternative_term: Metaphyseal chondrodysplasia, McKusick type
has_obo_namespace: disease_ontology
id: DOID:14773
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

blepharophimosis, ptosis, and epicanthus inversus syndrome
type: Class
subclass of: autosomal genetic disease
subclass of: syndrome
textual definition: A syndrome characterized by blepharophimosis, ptosis, epicanthus inversus, and telecanthus with (type I) or without (premature ovarian failure) that has_material_basis_in heterozygous or rarely homozygous mutation in FOXL2 on chromosome 3q22.3.
imported from: doid.owl
has cross-reference: MESH:C562419
has cross-reference: OMIM:110100
has cross-reference: SNOMEDCT_US_2020_03_01:79833006
has cross-reference: UMLS_CUI:C0220663
has_obo_namespace: disease_ontology
has_related_synonym: Blepharophimosis, ptosis, epicanthus inversus syndrome
id: DOID:14778
comment: OMIM mapping confirmed by DO. [SN].

KBG syndrome
type: Class
subclass of: spinal disease
subclass of: syndrome
textual definition: A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.
imported from: doid.owl
has cross-reference: GARD:82
has cross-reference: MESH:C537015
has cross-reference: OMIM:148050
has cross-reference: ORDO:2332
has cross-reference: SNOMEDCT_US_2020_03_01:711156009
has cross-reference: UMLS_CUI:C0220687
has_obo_namespace: disease_ontology
id: DOID:14780
in subset: DO rare slim
comment: OMIM mapping confirmed by DO. [SN].

spondyloepiphyseal dysplasia congenita
type: Class
subclass of: autosomal dominant disease
subclass of: spondyloepimetaphyseal dysplasia
imported from: doid.owl
has_alternative_id: DOID:0080025
has cross-reference: GARD:4987
has cross-reference: OMIM:183900
alternative_term: Late Spondyloepiphyseal Dysplasia
has_obo_namespace: disease_ontology
id: DOID:14789
comment: OMIM mapping confirmed by DO. [SN].

Leber congenital amaurosis
type: Class
subclass of: physical disorder
subclass of: retinal disease
textual definition: A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness.
imported from: doid.owl
has cross-reference: GARD:634
has cross-reference: MESH:D057130
has cross-reference: NCI:C129075
has cross-reference: OMIM:PS204000
has cross-reference: ORDO:65
has cross-reference: SNOMEDCT_US_2020_03_01:193413001
has cross-reference: UMLS_CUI:C0339527
alternative_term: LCA
alternative_term: Leber's amaurosis
alternative_term: Leber's congenital amaurosis
alternative_term: Leber's disease
has_obo_namespace: disease_ontology
id: DOID:14791
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

hypohidrotic ectodermal dysplasia
type: Class
subclass of: ectodermal dysplasia
textual definition: An ectodermal dysplasia that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth).
imported from: doid.owl
has_alternative_id: DOID:0050446
has_alternative_id: DOID:0050447
has cross-reference: GARD:76
has cross-reference: MESH:D053358
has cross-reference: NCI:C84562
has cross-reference: OMIM:129490
has cross-reference: OMIM:224900
has cross-reference: OMIM:300291
has cross-reference: OMIM:305100
has cross-reference: ORDO:238468
has cross-reference: SNOMEDCT_US_2020_03_01:239007005
has cross-reference: UMLS_CUI:C0162359
alternative_term: Christ-Siemens-Touraine Syndrome
alternative_term: Ectodermal Dysplasia 1, Anhydrotic
alternative_term: Hypohidrotic X-linked ectodermal dysplasia
alternative_term: anhidrotic ectodermal dysplasia 3
has_obo_namespace: disease_ontology
id: DOID:14793
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Dubowitz syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by microcephaly, growth retardation and a characteristic facial appearance including but not limited to narrow or triangular shaped head, micrognathia, ptosis, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.
imported from: doid.owl
has cross-reference: GARD:6290
has cross-reference: ICD10CM:Q87.19
has cross-reference: MEDDRA:10059589
has cross-reference: MESH:C535718
has cross-reference: NCI:C125591
has cross-reference: OMIM:223370
has cross-reference: SNOMEDCT_US_2020_03_01:2593002
has cross-reference: UMLS_CUI:C0175691
alternative_term: Dubowitz's syndrome
has_obo_namespace: disease_ontology
id: DOID:14796
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

gingival disease
type: Class
subclass of: periodontal disease
textual definition: A periodontal disease that is located_in the gums.
imported from: doid.owl
has cross-reference: MESH:D005882
has cross-reference: SNOMEDCT_US_2020_03_01:18718003
has cross-reference: UMLS_CUI:C0017563
alternative_term: gum disease
has_obo_namespace: disease_ontology
id: DOID:1483

cystic fibrosis
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs.
imported from: doid.owl
has_alternative_id: DOID:12447
has_alternative_id: DOID:13383
has_alternative_id: DOID:14395
has_alternative_id: DOID:1484
has cross-reference: GARD:6233
has cross-reference: ICD10CM:E84
has cross-reference: ICD9CM:277.0
has cross-reference: MESH:D003550
has cross-reference: NCI:C2975
has cross-reference: OMIM:219700
has cross-reference: ORDO:586
has cross-reference: SNOMEDCT_US_2020_03_01:85809002
has cross-reference: UMLS_CUI:C0010674
alternative_term: CF
alternative_term: mucoviscidosis
has_obo_namespace: disease_ontology
id: DOID:1485
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

echinococcosis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.
imported from: doid.owl
has_alternative_id: DOID:12149
has_alternative_id: DOID:2783
has cross-reference: ICD10CM:B67
has cross-reference: ICD9CM:122
has cross-reference: MESH:D004443
has cross-reference: NCI:C84682
has cross-reference: SNOMEDCT_US_2020_03_01:154414008
has cross-reference: UMLS_CUI:C0013502
alternative_term: Echinococcosis of liver
alternative_term: echinococcal disease
alternative_term: hepatic echinococcosis
alternative_term: hydatid disease
alternative_term: hydatidosis
alternative_term: liver echinococcus
alternative_term: pulmonary echinococcosis
has_obo_namespace: disease_ontology
id: DOID:1496
in subset: NCIthesaurus

cholera
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.
imported from: doid.owl
has cross-reference: GARD:6043
has cross-reference: ICD10CM:A00
has cross-reference: ICD9CM:001
has cross-reference: MESH:D002771
has cross-reference: SNOMEDCT_US_2020_03_01:186087007
has cross-reference: UMLS_CUI:C0008354
alternative_term: Cholera
alternative_term: Cholera - Vibrio cholerae
alternative_term: Cholera due to Vibrio cholerae
alternative_term: Vibrio cholerae
has_obo_namespace: disease_ontology
id: DOID:1498
in subset: DO FlyBase slim
in subset: GOLD
in subset: gram-negative bacterial infectious disease

reproductive system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in reproductive system organs.
imported from: doid.owl
has_alternative_id: DOID:6309
has cross-reference: NCI:C27613
has cross-reference: UMLS_CUI:C1335037
alternative_term: genital system disease
has_obo_namespace: disease_ontology
id: DOID:15
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

disease of mental health
type: Class
subclass of: disease
textual definition: A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.
imported from: doid.owl
has cross-reference: ICD10CM:F99
has cross-reference: MESH:D001523
has cross-reference: NCI:C2893
has cross-reference: SNOMEDCT_US_2020_03_01:74732009
has cross-reference: UMLS_CUI:C0004936
has_obo_namespace: disease_ontology
id: DOID:150
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

candidiasis
type: Class
subclass of: opportunistic mycosis
textual definition: An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons.
imported from: doid.owl
has_alternative_id: DOID:1507
has cross-reference: ICD10CM:B37
has cross-reference: ICD9CM:112
has cross-reference: MESH:D002177
has cross-reference: NCI:C26711
has cross-reference: SNOMEDCT_US_2020_03_01:154403005
has cross-reference: UMLS_CUI:C0006840
alternative_term: Disseminated candidiasis
alternative_term: systemic candidiasis
has_obo_namespace: disease_ontology
id: DOID:1508
in subset: NCIthesaurus

avoidant personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.
imported from: doid.owl
has cross-reference: ICD10CM:F60.6
has cross-reference: ICD9CM:301.82
has cross-reference: MESH:D010554
has cross-reference: NCI:C92636
has cross-reference: SNOMEDCT_US_2020_03_01:191771004
has cross-reference: UMLS_CUI:C0004444
alternative_term: anxious personality disorder
has_obo_namespace: disease_ontology
id: DOID:1509
in subset: NCIthesaurus

personality disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.
imported from: doid.owl
has cross-reference: ICD9CM:301.8
has cross-reference: SNOMEDCT_US_2020_03_01:191770003
has cross-reference: UMLS_CUI:C0029707
alternative_term: character disorder
has_obo_namespace: disease_ontology
id: DOID:1510

cecal disease
type: Class
subclass of: intestinal disease
textual definition: An intestinal disease located_in the cecum.
imported from: doid.owl
has cross-reference: MESH:D002429
has cross-reference: SNOMEDCT_US_2020_03_01:128525008
has cross-reference: UMLS_CUI:C0007527
alternative_term: disorder of cecum
has_obo_namespace: disease_ontology
id: DOID:1518

cecum carcinoma
type: Class
subclass of: cecum cancer
subclass of: carcinoma
textual definition: A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C3491
has cross-reference: SNOMEDCT_US_2020_03_01:269538009
has cross-reference: UMLS_CUI:C0149640
alternative_term: Caecum carcinoma
alternative_term: Cecal cancer
alternative_term: carcinoma of cecum
has_obo_namespace: disease_ontology
id: DOID:1519
in subset: NCIthesaurus

cecum cancer
type: Class
subclass of: cecal disease
subclass of: large intestine cancer
textual definition: A large intestine cancer that is located_in the cecum.
imported from: doid.owl
has cross-reference: ICD10CM:C18.0
has cross-reference: ICD9CM:153.4
has cross-reference: MESH:D002430
has cross-reference: NCI:C9329
has cross-reference: SNOMEDCT_US_2020_03_01:93736007
has cross-reference: UMLS_CUI:C0153437
alternative_term: malignant neoplasm of caecum
alternative_term: malignant tumor of the cecum
has_obo_namespace: disease_ontology
id: DOID:1521
in subset: NCIthesaurus

panniculitis
type: Class
subclass of: skin disease
textual definition: A skin disease that is characterized by inflammation of subcutaneous adipose tissue.
imported from: doid.owl
has cross-reference: ICD10CM:M79.3
has cross-reference: ICD9CM:729.30
has cross-reference: MESH:D015434
has cross-reference: NCI:C112112
has cross-reference: SNOMEDCT_US_2020_03_01:268122002
has cross-reference: UMLS_CUI:C0030326
has_obo_namespace: disease_ontology
id: DOID:1526
in subset: NCIthesaurus

penile disease
type: Class
subclass of: male reproductive system disease
imported from: doid.owl
has cross-reference: ICD10CM:N48.8
has cross-reference: ICD9CM:607.8
has cross-reference: SNOMEDCT_US_2020_03_01:198558008
has cross-reference: UMLS_CUI:C0029785
has_obo_namespace: disease_ontology
id: DOID:1529

pleural disease
type: Class
subclass of: lower respiratory tract disease
textual definition: A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.
imported from: doid.owl
has_alternative_id: DOID:1531
has cross-reference: MESH:D010995
has cross-reference: NCI:C26859
has cross-reference: SNOMEDCT_US_2020_03_01:88075009
has cross-reference: UMLS_CUI:C0032226
alternative_term: disorder of pleura
alternative_term: non-neoplastic pleural disease
has_obo_namespace: disease_ontology
id: DOID:1532
in subset: NCIthesaurus

mixed cell type cancer
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from two germinal layers of tissue.
imported from: doid.owl
has_alternative_id: DOID:1905
has cross-reference: MESH:D018198
has cross-reference: NCI:C3729
has cross-reference: NCI:C6930
has cross-reference: SNOMEDCT_US_2020_03_01:8145008
has cross-reference: UMLS_CUI:C0206625
has cross-reference: UMLS_CUI:C1368354
alternative_term: malignant mixed cancer
alternative_term: malignant mixed neoplasm
alternative_term: mixed tumor
alternative_term: mixed tumor, malignant
has_obo_namespace: disease_ontology
has_related_synonym: malignant mixed tumor
has_related_synonym: mixed neoplasm
id: DOID:154
in subset: NCIthesaurus

parathyroid carcinoma
type: Class
subclass of: parathyroid gland disease
subclass of: endocrine gland cancer
subclass of: carcinoma
textual definition: An endocrine gland cancer located_in the parathyroid glands located in the neck.
imported from: doid.owl
has_alternative_id: DOID:11006
has_alternative_id: DOID:1541
has cross-reference: GARD:7329
has cross-reference: ICD10CM:C75.0
has cross-reference: ICD9CM:194.1
has cross-reference: MESH:D010282
has cross-reference: NCI:C3313
has cross-reference: NCI:C4906
has cross-reference: NCI:C9322
has cross-reference: OMIM:608266
has cross-reference: SNOMEDCT_US_2020_03_01:127020005
has cross-reference: SNOMEDCT_US_2020_03_01:363481002
has cross-reference: UMLS_CUI:C0030521
has cross-reference: UMLS_CUI:C0153653
has cross-reference: UMLS_CUI:C0687150
alternative_term: Parathyroid gland neoplasm
alternative_term: carcinoma of Parathyroid gland
alternative_term: malignant neoplasm of parathyroid gland
alternative_term: malignant neoplasm of the Parathyroid
alternative_term: malignant tumor of parathyroid gland
alternative_term: neoplasm of parathyroid gland
alternative_term: parathyroid gland cancer
alternative_term: parathyroid neoplasm
has_obo_namespace: disease_ontology
has_related_synonym: parathyroid gland adenocarcinoma
id: DOID:1540
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

urticaria
type: Class
subclass of: skin disease
textual definition: A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis.
imported from: doid.owl
has cross-reference: ICD9CM:708.8
has cross-reference: SNOMEDCT_US_2020_03_01:267817001
has cross-reference: UMLS_CUI:C0029839
has_obo_namespace: disease_ontology
id: DOID:1555

hypersensitivity reaction type III disease
type: Class
subclass of: hypersensitivity reaction disease
textual definition: A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury.
imported from: doid.owl
has cross-reference: MESH:D007105
has cross-reference: UMLS_CUI:C0020951
alternative_term: immune complex disease
has_obo_namespace: disease_ontology
id: DOID:1557

angioedema
type: Class
subclass of: skin disease
textual definition: A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues.
imported from: doid.owl
has cross-reference: ICD10CM:T78.3
has cross-reference: MESH:D000799
has cross-reference: NCI:C112175
has cross-reference: SNOMEDCT_US_2020_03_01:41291007
has cross-reference: UMLS_CUI:C0002994
alternative_term: Angioneurotic oedema
alternative_term: Quincke's edema
alternative_term: angioneurotic edema
alternative_term: giant urticaria
has_obo_namespace: disease_ontology
id: DOID:1558
in subset: NCIthesaurus

cognitive disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.
imported from: doid.owl
has cross-reference: ICD10CM:F09
has cross-reference: MESH:D019965
has cross-reference: NCI:C34870
has cross-reference: SNOMEDCT_US_2020_03_01:111479008
has cross-reference: UMLS_CUI:C0029227
alternative_term: cognitive disease
has_obo_namespace: disease_ontology
has_related_synonym: Organic Mental disorder
id: DOID:1561
in subset: NCIthesaurus

chromoblastomycosis
type: Class
subclass of: subcutaneous mycosis
textual definition: A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.
imported from: doid.owl
has cross-reference: GARD:1319
has cross-reference: ICD10CM:B43.9
has cross-reference: ICD9CM:117.2
has cross-reference: MESH:D002862
has cross-reference: SNOMEDCT_US_2020_03_01:187079000
has cross-reference: UMLS_CUI:C0008582
alternative_term: Chromomycosis
alternative_term: Mossy foot disease
has_obo_namespace: disease_ontology
id: DOID:1562

dermatomycosis
type: Class
subclass of: cutaneous mycosis
subclass of: skin disease
textual definition: A cutaneous mycosis that results in fungal infection located in skin or of its appendages, has_material_basis_in Ascomycota fungi other than the dermatophytes.
imported from: doid.owl
has cross-reference: ICD9CM:111.9
has cross-reference: MESH:D003881
has cross-reference: SNOMEDCT_US_2020_03_01:47382004
has cross-reference: UMLS_CUI:C0011630
has_obo_namespace: disease_ontology
id: DOID:1563

fungal infectious disease
type: Class
subclass of: disease by infectious agent
textual definition: A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.
imported from: doid.owl
has cross-reference: ICD10CM:B49
has cross-reference: ICD9CM:110-118.99
has cross-reference: MESH:D009181
has cross-reference: NCI:C3245
has cross-reference: SNOMEDCT_US_2020_03_01:154393000
has cross-reference: UMLS_CUI:C0026946
alternative_term: mycosis
has_obo_namespace: disease_ontology
has_related_synonym: mycoses
id: DOID:1564
in subset: DO AGR slim
in subset: NCIthesaurus

ectropion
type: Class
subclass of: eyelid disease
imported from: doid.owl
has cross-reference: ICD10CM:H02.1
has cross-reference: ICD9CM:374.1
has cross-reference: MESH:D004483
has cross-reference: SNOMEDCT_US_2020_03_01:155178000
has cross-reference: UMLS_CUI:C0013592
alternative_term: Ectropion of eyelid
alternative_term: Everted margin
has_obo_namespace: disease_ontology
id: DOID:1570

normal pressure hydrocephalus
type: Class
subclass of: communicating hydrocephalus
imported from: doid.owl
has cross-reference: ICD10CM:G91.2
has cross-reference: MESH:D006850
has cross-reference: OMIM:236690
has cross-reference: SNOMEDCT_US_2020_03_01:30753002
has cross-reference: UMLS_CUI:C0020258
alternative_term: Low pressure hydrocephalus
has_obo_namespace: disease_ontology
id: DOID:1572
comment: OMIM mapping confirmed by DO. [SN].

communicating hydrocephalus
type: Class
subclass of: hydrocephalus
imported from: doid.owl
has cross-reference: ICD10CM:G91.0
has cross-reference: ICD9CM:331.3
has cross-reference: MESH:D006849
has cross-reference: NCI:C34501
has cross-reference: SNOMEDCT_US_2020_03_01:59013007
has cross-reference: UMLS_CUI:C0009451
has_obo_namespace: disease_ontology
id: DOID:1573
in subset: NCIthesaurus

rheumatic disease
type: Class
subclass of: connective tissue disease
textual definition: A musculoskeletal system disease that involves inflammation or pain in the muscles, joints, or fibrous tissue.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:1575

respiratory system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm.
imported from: doid.owl
has_alternative_id: DOID:3226
has cross-reference: ICD10CM:J98
has cross-reference: ICD9CM:519
has cross-reference: SNOMEDCT_US_2020_03_01:155603009
has cross-reference: UMLS_CUI:C0029582
has_obo_namespace: disease_ontology
id: DOID:1579
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

laryngeal tuberculosis
type: Class
subclass of: laryngitis
textual definition: A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.
imported from: doid.owl
has cross-reference: ICD10CM:A15.5
has cross-reference: ICD9CM:012.3
has cross-reference: MESH:D014387
has cross-reference: NCI:C26895
has cross-reference: SNOMEDCT_US_2020_03_01:70341005
has cross-reference: UMLS_CUI:C0041315
has_obo_namespace: disease_ontology
id: DOID:1583
in subset: NCIthesaurus

acute chest syndrome
type: Class
subclass of: lung disease
textual definition: A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.
imported from: doid.owl
has cross-reference: ICD9CM:517.3
has cross-reference: MESH:D056586
has cross-reference: NCI:C138179
has cross-reference: SNOMEDCT_US_2020_03_01:372146004
has cross-reference: UMLS_CUI:C0742343
alternative_term: acute chest syndrome in sickle cell disease
has_obo_namespace: disease_ontology
id: DOID:1584
in subset: NCIthesaurus

rheumatic fever
type: Class
subclass of: bacterial infectious disease
textual definition: A connective tissue disease that develops from an antecedent Group A Streptococcal pharyngeal infection and has_symptom carditis, has_symptom polyarthritis, has_symptom chorea, has_symptom erythema marginatum, has_symptom subcutaneous nodules, has_symptom arthralgia, has_symptom prolonged PR interval, and/or has_symptom fever.
imported from: doid.owl
has_alternative_id: DOID:1006
has_alternative_id: DOID:1007
has cross-reference: GARD:5699
has cross-reference: ICD10CM:I00
has cross-reference: ICD10CM:I00-I02
has cross-reference: ICD9CM:390
has cross-reference: ICD9CM:390-392.99
has cross-reference: MESH:D012213
has cross-reference: NCI:C34984
has cross-reference: SNOMEDCT_US_2020_03_01:155265007
has cross-reference: SNOMEDCT_US_2020_03_01:274095001
has cross-reference: UMLS_CUI:C0035436
has cross-reference: UMLS_CUI:C0264743
alternative_term: ACUTE RHEUMATIC FEVER
alternative_term: RhF - Rheumatic fever
has_obo_namespace: disease_ontology
id: DOID:1586
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

thrombocytopenia due to platelet alloimmunization
type: Class
subclass of: thrombocytopenia
imported from: doid.owl
has cross-reference: NCI:C3991
has cross-reference: SNOMEDCT_US_2020_03_01:2897005
has cross-reference: UMLS_CUI:C0272286
alternative_term: Auto-immune thrombocytopenia
alternative_term: Immune thrombocytopenia
alternative_term: Thrombocytopenia Due to Immune Destruction
has_obo_namespace: disease_ontology
id: DOID:1587
in subset: NCIthesaurus

thrombocytopenia
type: Class
subclass of: blood platelet disease
textual definition: A blood platelet disease that is characterized by low a platelet count in the blood.
imported from: doid.owl
has cross-reference: ICD10CM:D69.6
has cross-reference: ICD9CM:287.5
has cross-reference: MESH:D013921
has cross-reference: OMIM:188000
has cross-reference: OMIM:273900
has cross-reference: OMIM:300367
has cross-reference: OMIM:313900
has cross-reference: OMIM:612004
has cross-reference: ORDO:852
has cross-reference: SNOMEDCT_US_2020_03_01:165556002
has cross-reference: UMLS_CUI:C0040034
has_obo_namespace: disease_ontology
id: DOID:1588
in subset: DO rare slim
comment: Xref MGI.

endogenous depression
type: Class
subclass of: major depressive disorder
textual definition: A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system.
imported from: doid.owl
has_alternative_id: DOID:6340
has cross-reference: EFO:0003761
has cross-reference: MESH:D003866
has cross-reference: NCI:C34532
has cross-reference: NCI:C35094
has cross-reference: OMIM:608516
has cross-reference: SNOMEDCT_US_2020_03_01:191599006
has cross-reference: UMLS_CUI:C0011573
has cross-reference: UMLS_CUI:C0041696
alternative_term: clinical depression
alternative_term: unipolar depression
has_obo_namespace: disease_ontology
id: DOID:1595
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

mental depression
type: Class
subclass of: mood disorder
imported from: doid.owl
has_alternative_id: DOID:14672
has cross-reference: ICD10CM:F32.9
has cross-reference: MESH:D003863
has cross-reference: NCI:C2982
has cross-reference: SNOMEDCT_US_2020_03_01:41006004
has cross-reference: UMLS_CUI:C0011570
has_obo_namespace: disease_ontology
id: DOID:1596
in subset: NCIthesaurus

integumentary system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:16
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

lymphadenitis
type: Class
subclass of: DOID 9942
imported from: doid.owl
has_alternative_id: DOID:1600
has_alternative_id: DOID:9941
has cross-reference: ICD10CM:I88.1
has cross-reference: ICD10CM:L04
has cross-reference: ICD9CM:289.1
has cross-reference: ICD9CM:683
has cross-reference: MESH:D008199
has cross-reference: NCI:C26821
has cross-reference: NCI:C26966
has cross-reference: NCI:C26978
has cross-reference: SNOMEDCT_US_2020_03_01:154836001
has cross-reference: SNOMEDCT_US_2020_03_01:156318008
has cross-reference: SNOMEDCT_US_2020_03_01:19471005
has cross-reference: UMLS_CUI:C0024205
has cross-reference: UMLS_CUI:C0154304
has cross-reference: UMLS_CUI:C0157705
alternative_term: Adenitis
alternative_term: Inflammation of lymph node
alternative_term: acute adenitis
alternative_term: acute lymphadenitis
alternative_term: chronic Lymphadenitis
alternative_term: chronic adenitis
has_obo_namespace: disease_ontology
id: DOID:1602
in subset: NCIthesaurus

hypoglycemic coma
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by coma or unconsciousness, develops from a prolonged insufficient supply of glucose to the brain, has_symptom decreased cognition, has_symptom aberrant behavior, has_symptom seizure, and has_symptom coma.
imported from: doid.owl
has cross-reference: ICD10CM:E15
has cross-reference: ICD9CM:251.0
has cross-reference: SNOMEDCT_US_2020_03_01:267476006
has cross-reference: UMLS_CUI:C0020617
has_obo_namespace: disease_ontology
id: DOID:1607

keratosis
type: Class
subclass of: skin disease
textual definition: A skin disease characterized_by growth of keratin on the skin or mucous membranes.
imported from: doid.owl
has cross-reference: MESH:D007642
has cross-reference: NCI:C34747
has cross-reference: SNOMEDCT_US_2020_03_01:254666005
has cross-reference: UMLS_CUI:C0022593
has_obo_namespace: disease_ontology
id: DOID:161
in subset: NCIthesaurus

breast cancer
type: Class
subclass of: breast disease
subclass of: thoracic cancer
textual definition: A thoracic cancer that originates in the mammary gland.
imported from: doid.owl
has_alternative_id: DOID:1648
has_alternative_id: DOID:4241
has cross-reference: ICD10CM:C50
has cross-reference: MESH:D001943
has cross-reference: NCI:C9335
has cross-reference: OMIM:114480
has cross-reference: SNOMEDCT_US_2020_03_01:254837009
has cross-reference: UMLS_CUI:C0006142
alternative_term: breast tumor
alternative_term: malignant neoplasm of breast
alternative_term: malignant tumor of the breast
alternative_term: mammary cancer
alternative_term: mammary tumor
alternative_term: primary breast cancer
has_obo_namespace: disease_ontology
has_related_synonym: mammary neoplasm
id: DOID:1612
in subset: DO cancer slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

breast fibroadenoma
type: Class
subclass of: breast benign neoplasm
subclass of: adenoma
textual definition: A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast.
imported from: doid.owl
has_alternative_id: DOID:2684
has_alternative_id: DOID:2693
has_alternative_id: DOID:7226
has cross-reference: ICD10CM:D24
has cross-reference: MESH:D018226
has cross-reference: NCI:C3744
has cross-reference: NCI:C4276
has cross-reference: NCI:C5194
has cross-reference: SNOMEDCT_US_2020_03_01:254847007
has cross-reference: SNOMEDCT_US_2020_03_01:269640007
has cross-reference: SNOMEDCT_US_2020_03_01:65877006
has cross-reference: UMLS_CUI:C0178421
has cross-reference: UMLS_CUI:C0206650
has cross-reference: UMLS_CUI:C0346158
has cross-reference: UMLS_CUI:C1333137
alternative_term: Complex Fibroadenoma of breast
alternative_term: Fibroadenoma
alternative_term: Fibroadenoma of breast
alternative_term: Juvenile fibroadenoma
alternative_term: cellular Fibroadenoma
alternative_term: fibroadenoma
alternative_term: juvenile fibroadenoma of breast
has_obo_namespace: disease_ontology
id: DOID:1618
in subset: NCIthesaurus

cancer
type: Class
subclass of: disease of cellular proliferation
textual definition: A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
imported from: doid.owl
has cross-reference: ICD10CM:C80.1
has cross-reference: ICD9CM:199
has cross-reference: ICDO:M8000/3
has cross-reference: MESH:D009369
has cross-reference: NCI:C9305
has cross-reference: SNOMEDCT_US_2020_03_01:269513004
has cross-reference: UMLS_CUI:C0006826
alternative_term: malignant neoplasm
alternative_term: malignant tumor
alternative_term: primary cancer
has_obo_namespace: disease_ontology
id: DOID:162
in subset: DO AGR slim
in subset: DO FlyBase slim
in subset: DO GXD slim
in subset: NCIthesaurus
comment: Updating out dated UMLS CUI.

breast adenoma
type: Class
subclass of: breast benign neoplasm
subclass of: adenoma
textual definition: A breast benign neoplasm that is has_material_basis_in epithelial tissue in which tumor cells form glands or glandlike structures.
imported from: doid.owl
has cross-reference: NCI:C40382
has cross-reference: SNOMEDCT_US_2020_03_01:269640007
has cross-reference: UMLS_CUI:C1328385
alternative_term: Ademoma - breast
has_obo_namespace: disease_ontology
id: DOID:1625
in subset: NCIthesaurus

intraductal papilloma
type: Class
subclass of: papilloma
subclass of: intraductal breast benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D018300
has cross-reference: NCI:C3785
has cross-reference: SNOMEDCT_US_2020_03_01:5244003
has cross-reference: UMLS_CUI:C0206713
alternative_term: ductal papilloma
has_obo_namespace: disease_ontology
id: DOID:1627
in subset: NCIthesaurus

breast adenomyoepithelioma
type: Class
subclass of: breast myoepithelial neoplasm
textual definition: A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells.
imported from: doid.owl
has_alternative_id: DOID:6640
has cross-reference: NCI:C5143
has cross-reference: NCI:C6899
has cross-reference: UMLS_CUI:C1334564
has cross-reference: UMLS_CUI:C1510795
alternative_term: breast Adenomyoepithelioma with malignant Change
alternative_term: malignant adenomyoepithelioma of breast
has_obo_namespace: disease_ontology
has_related_synonym: adenomyoepithelioma of the breast
id: DOID:1642
in subset: NCIthesaurus

ventricular septal defect
type: Class
subclass of: heart septal defect
textual definition: A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles.
imported from: doid.owl
has cross-reference: GARD:7853
has cross-reference: ICD10CM:Q21.0
has cross-reference: ICD9CM:745.4
has cross-reference: MESH:D006345
has cross-reference: NCI:C84506
has cross-reference: OMIM:614429
has cross-reference: OMIM:614431
has cross-reference: OMIM:614432
has cross-reference: ORDO:1480
has cross-reference: SNOMEDCT_US_2020_03_01:156914003
has cross-reference: UMLS_CUI:C0018818
alternative_term: Interventricular septal defect
alternative_term: Ventricular septal abnormality
has_obo_namespace: disease_ontology
id: DOID:1657
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

supratentorial cancer
type: Class
subclass of: brain cancer
textual definition: A brain cancer that is located in the supratentorial region.
imported from: doid.owl
has_alternative_id: DOID:1658
has cross-reference: ICD10CM:C71.0
has cross-reference: MESH:D015173
has cross-reference: NCI:C3397
has cross-reference: NCI:C4964
has cross-reference: UMLS_CUI:C0038874
has cross-reference: UMLS_CUI:C0751589
alternative_term: Brain neoplasm, Supratentorial
alternative_term: malignant Supratentorial tumor
has_obo_namespace: disease_ontology
id: DOID:1659
in subset: NCIthesaurus

melanotic neuroectodermal tumor
type: Class
subclass of: bone benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D017600
has cross-reference: NCI:C3717
has cross-reference: SNOMEDCT_US_2020_03_01:1513001
has cross-reference: UMLS_CUI:C0206094
alternative_term: Infantile Melanotic neuroectodermal neoplasm
alternative_term: Melanotic neuroectodermal tumor
alternative_term: Melanotic neuroectodermal tumor of infancy
alternative_term: Melanotic neuroectodermal tumour
alternative_term: Melanotic neuroectodermal tumour of infancy
alternative_term: Pigmented neuroectodermal tumour of infancy
alternative_term: melanotic neuroectodermal tumour
has_obo_namespace: disease_ontology
id: DOID:166
in subset: NCIthesaurus

pineoblastoma
type: Class
subclass of: pineal gland cancer
textual definition: A pineal gland neoplasm located_in the brain.
imported from: doid.owl
has cross-reference: GARD:9369
has cross-reference: MESH:D010871
has cross-reference: NCI:C9344
has cross-reference: SNOMEDCT_US_2020_03_01:31671006
has cross-reference: UMLS_CUI:C0205898
alternative_term: Pineal PNET
has_obo_namespace: disease_ontology
id: DOID:1664
in subset: DO cancer slim
in subset: NCIthesaurus

pneumothorax
type: Class
subclass of: pleural disease
textual definition: A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall.
imported from: doid.owl
has cross-reference: ICD10CM:J93.1
has cross-reference: SNOMEDCT_US_2020_03_01:196103008
has cross-reference: UMLS_CUI:C0029850
has_obo_namespace: disease_ontology
id: DOID:1673

cystitis
type: Class
subclass of: bladder disease
textual definition: A bladder disease that is characterized by inflammation of the bladder.
imported from: doid.owl
has cross-reference: ICD10CM:N30
has cross-reference: ICD9CM:595
has cross-reference: MESH:D003556
has cross-reference: NCI:C26738
has cross-reference: SNOMEDCT_US_2020_03_01:38822007
has cross-reference: UMLS_CUI:C0010692
has_obo_namespace: disease_ontology
id: DOID:1679
in subset: NCIthesaurus

heart septal defect
type: Class
subclass of: congenital heart disease
imported from: doid.owl
has cross-reference: ICD10CM:Q21.9
has cross-reference: MESH:D006343
has cross-reference: NCI:C84482
has cross-reference: SNOMEDCT_US_2020_03_01:204290008
has cross-reference: UMLS_CUI:C0018816
alternative_term: Cardiac septal defects
alternative_term: Congenital septal defect of heart
alternative_term: Septal defect
alternative_term: septal defect
has_obo_namespace: disease_ontology
id: DOID:1681
in subset: NCIthesaurus

congenital heart disease
type: Class
subclass of: physical disorder
subclass of: heart disease
imported from: doid.owl
has cross-reference: ICD10CM:Q24.9
has cross-reference: ICD9CM:746.9
has cross-reference: MESH:D006330
has cross-reference: NCI:C34666
has cross-reference: SNOMEDCT_US_2020_03_01:268315002
has cross-reference: UMLS_CUI:C0018798
alternative_term: Congenital Heart Defects
alternative_term: Congenital anomaly of heart
alternative_term: Heart Malformation
alternative_term: congenital heart defect
alternative_term: heart defect
has_obo_namespace: disease_ontology
has_related_synonym: Heart-congenital defect
id: DOID:1682
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

glaucoma
type: Class
subclass of: eye disease
textual definition: An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function.
imported from: doid.owl
has cross-reference: EFO:0000516
has cross-reference: ICD10CM:H40
has cross-reference: ICD9CM:365
has cross-reference: MESH:D005901
has cross-reference: NCI:C26782
has cross-reference: SNOMEDCT_US_2020_03_01:155120009
has cross-reference: UMLS_CUI:C0017601
has_obo_namespace: disease_ontology
id: DOID:1686
in subset: DO FlyBase slim
in subset: NCIthesaurus

neovascular glaucoma
type: Class
subclass of: glaucoma
textual definition: A glaucoma characterized by narrowing of the anterior chamber angle secondary to neovascularization along the iris and iridocorneal angle such that the aqueous fluid outflow is blocked and intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Neovascular glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Neovascular glaucoma can be related to abnormal angiogenesis with ischemic retinal diseases, inflammation, diabetes mellitus, intraocular malignancy, and autoinmmune diseases.
imported from: doid.owl
has cross-reference: MESH:D015355
has cross-reference: SNOMEDCT_US_2020_03_01:193564003
has cross-reference: UMLS_CUI:C0017609
alternative_term: secondary angle-closure glaucoma with rubeosis
has_obo_namespace: disease_ontology
id: DOID:1687

neuroendocrine tumor
type: Class
subclass of: endocrine gland cancer
textual definition: An endocrine gland cancer that has_material_basis_in neuroendocrine cells.
imported from: doid.owl
has cross-reference: ICD10CM:D3A.8
has cross-reference: ICD9CM:209-209.99
has cross-reference: MESH:D018358
has cross-reference: NCI:C3809
has cross-reference: SNOMEDCT_US_2020_03_01:55937004
has cross-reference: UMLS_CUI:C0206754
alternative_term: neuroendocrine neoplasm
has_obo_namespace: disease_ontology
id: DOID:169
in subset: NCIthesaurus

ichthyosis
type: Class
subclass of: skin disease
textual definition: A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed.
imported from: doid.owl
has cross-reference: MESH:D007057
has cross-reference: ORDO:79354
alternative_term: ichthyoses
alternative_term: non-syndromic ichthyosis
has_obo_namespace: disease_ontology
id: DOID:1697

musculoskeletal system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that occurs in the muscular and/or skeletal system.
imported from: doid.owl
has cross-reference: MESH:D009140
has cross-reference: NCI:C107377
has cross-reference: SNOMEDCT_US_2020_03_01:268047003
has cross-reference: UMLS_CUI:C0026857
has_obo_namespace: disease_ontology
id: DOID:17
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

endocrine gland cancer
type: Class
subclass of: organ system cancer
textual definition: An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.
imported from: doid.owl
has_alternative_id: DOID:10009
has cross-reference: ICD10CM:C75.9
has cross-reference: ICD9CM:194.9
has cross-reference: MESH:D004701
has cross-reference: NCI:C3010
has cross-reference: NCI:C3575
has cross-reference: SNOMEDCT_US_2020_03_01:127015005
has cross-reference: SNOMEDCT_US_2020_03_01:93780007
has cross-reference: UMLS_CUI:C0014132
has cross-reference: UMLS_CUI:C0153658
alternative_term: Endocrine tumor
alternative_term: endocrine neoplasm
alternative_term: malignant Endocrine tumor
alternative_term: malignant neoplasm of endocrine gland
alternative_term: malignant tumour of endocrine gland
alternative_term: neoplasm of endocrine gland
alternative_term: neoplasm of endocrine system
has_obo_namespace: disease_ontology
id: DOID:170
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

X-linked ichthyosis
type: Class
subclass of: X-linked recessive disease
subclass of: ichthyosis
textual definition: An ichthyosis that is characterized by a build-up of scales on the skin, typically on the back of the neck and trunk resulting from skin cells that do not properly separate from the outermost surface of the skin, and has_material_basis_in X-linked recessive mutation or deletion of the STS gene on chromosome Xp22.
imported from: doid.owl
has cross-reference: GARD:7904
has cross-reference: ICD10CM:Q80.1
has cross-reference: MESH:D016114
has cross-reference: NCI:C84779
has cross-reference: OMIM:308100
has cross-reference: SNOMEDCT_US_2020_03_01:72523005
has cross-reference: UMLS_CUI:C0079588
alternative_term: X-linked ichthyosis with steryl-sulphatase deficiency
alternative_term: X-linked placental steryl-sulphatase deficiency
alternative_term: X-linked recessive ichthyosis
has_obo_namespace: disease_ontology
id: DOID:1700
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

steroid inherited metabolic disorder
type: Class
subclass of: lipid metabolism disorder
textual definition: A lipid metabolism disorder that involves defects in steroid metabolism.
imported from: doid.owl
has cross-reference: MESH:D043202
has cross-reference: UMLS_CUI:C1257809
has_obo_namespace: disease_ontology
id: DOID:1701

ichthyosis vulgaris
type: Class
subclass of: autosomal dominant disease
subclass of: ichthyosis
textual definition: An ichthyosis that has_material_basis_in heterozygous mutation in the filaggrin gene on chromosome 1q21 and is characterized by dead skin cells accumulate in thick, dry scales on your skin's surface.
imported from: doid.owl
has cross-reference: GARD:6752
has cross-reference: ICD10CM:Q80.0
has cross-reference: MESH:D016112
has cross-reference: NCI:C84778
has cross-reference: OMIM:146700
has cross-reference: SNOMEDCT_US_2020_03_01:205551004
has cross-reference: UMLS_CUI:C0079584
alternative_term: Dominant congenital ichthyosiform erythroderma
has_obo_namespace: disease_ontology
id: DOID:1702
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

neuroectodermal tumor
type: Class
subclass of: nervous system cancer
imported from: doid.owl
has cross-reference: MESH:D017599
has cross-reference: SNOMEDCT_US_2020_03_01:73676002
has cross-reference: UMLS_CUI:C0206093
alternative_term: primitive Neuroectodermal neoplasm
has_obo_namespace: disease_ontology
id: DOID:171

aortic valve stenosis
type: Class
subclass of: aortic valve disease
textual definition: An aortic valve disease that is characterized by narrowing of the heart's aortic valve opening.
imported from: doid.owl
has_alternative_id: DOID:12034
has_alternative_id: DOID:1711
has cross-reference: GARD:5830
has cross-reference: ICD10CM:I06.0
has cross-reference: ICD10CM:Q23.0
has cross-reference: ICD10CM:Q25.1
has cross-reference: ICD9CM:395.0
has cross-reference: ICD9CM:746.3
has cross-reference: MESH:D001024
has cross-reference: NCI:C50462
has cross-reference: SNOMEDCT_US_2020_03_01:155282009
has cross-reference: SNOMEDCT_US_2020_03_01:18546004
has cross-reference: SNOMEDCT_US_2020_03_01:60573004
has cross-reference: UMLS_CUI:C0003507
has cross-reference: UMLS_CUI:C0152417
has cross-reference: UMLS_CUI:C0155567
alternative_term: Aortic stenosis
alternative_term: Rheumatic aortic stenosis
alternative_term: rheumatic aortic valve stenosis
has_obo_namespace: disease_ontology
id: DOID:1712
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

clear cell acanthoma
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D049309
has cross-reference: NCI:C97041
has cross-reference: SNOMEDCT_US_2020_03_01:65540008
has cross-reference: UMLS_CUI:C0333992
alternative_term: Clear cell acanthoma
alternative_term: Pale (Clear cell) acanthoma
has_obo_namespace: disease_ontology
id: DOID:172
in subset: NCIthesaurus

duodenal ulcer
type: Class
subclass of: peptic ulcer disease
imported from: doid.owl
has_alternative_id: DOID:10297
has_alternative_id: DOID:11480
has_alternative_id: DOID:12880
has_alternative_id: DOID:13836
has_alternative_id: DOID:1723
has_alternative_id: DOID:9780
has_alternative_id: DOID:9781
has_alternative_id: DOID:9782
has_alternative_id: DOID:9783
has cross-reference: ICD10CM:K26
has cross-reference: ICD9CM:532
has cross-reference: MESH:D004381
has cross-reference: NCI:C26755
has cross-reference: SNOMEDCT_US_2020_03_01:155691003
has cross-reference: SNOMEDCT_US_2020_03_01:39755000
has cross-reference: UMLS_CUI:C0010474
has cross-reference: UMLS_CUI:C0013295
alternative_term: Curling Ulcer
alternative_term: Curling's ulcers
alternative_term: Stress Ulcer
has_obo_namespace: disease_ontology
id: DOID:1724
in subset: NCIthesaurus
comment: Adding UMLS CUI for Curling Ulcer C0013295.

peritoneum cancer
type: Class
subclass of: organ system cancer
textual definition: An organ system cancer that is located in the peritoneum.
imported from: doid.owl
has cross-reference: ICD10CM:C48.1
has cross-reference: ICD9CM:158.8
has cross-reference: SNOMEDCT_US_2020_03_01:187808008
has cross-reference: UMLS_CUI:C0153466
has_obo_namespace: disease_ontology
has_related_synonym: cancer of peritoneum
has_related_synonym: peritoneal neoplasm
id: DOID:1725
in subset: DO MGI slim
in subset: TopNodes DOcancerslim

retinal vein occlusion
type: Class
subclass of: retinal artery occlusion
subclass of: DOID 866
imported from: doid.owl
has cross-reference: MESH:D012170
has cross-reference: NCI:C34981
has cross-reference: SNOMEDCT_US_2020_03_01:46085004
has cross-reference: UMLS_CUI:C0035328
alternative_term: Occlusion, of retinal vein
alternative_term: Retinal vein occlusion
has_obo_namespace: disease_ontology
id: DOID:1727
in subset: NCIthesaurus

retinal vascular occlusion
type: Class
subclass of: retinal vascular disease
subclass of: peripheral vascular disease
imported from: doid.owl
has cross-reference: ICD10CM:H34
has cross-reference: ICD9CM:362.3
has cross-reference: NCI:C34980
has cross-reference: SNOMEDCT_US_2020_03_01:267717005
has cross-reference: UMLS_CUI:C0035326
alternative_term: Retinal vasc. occlusion
has_obo_namespace: disease_ontology
id: DOID:1729
in subset: NCIthesaurus

eccrine sweat gland neoplasm
type: Class
subclass of: sweat gland benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C6796
has cross-reference: UMLS_CUI:C1333371
alternative_term: Eccrine tumor
alternative_term: eccrine skin neoplasm
has_obo_namespace: disease_ontology
id: DOID:173
in subset: NCIthesaurus

histoplasmosis
type: Class
subclass of: primary systemic mycosis
textual definition: A primary systemic mycosis that results in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.
imported from: doid.owl
has_alternative_id: DOID:351
has cross-reference: ICD10CM:B39
has cross-reference: ICD9CM:115
has cross-reference: MESH:C538362
has cross-reference: MESH:D006660
has cross-reference: NCI:C34977
has cross-reference: NCI:C77201
has cross-reference: SNOMEDCT_US_2020_03_01:266218008
has cross-reference: UMLS_CUI:C0019655
has cross-reference: UMLS_CUI:C0035288
has_obo_namespace: disease_ontology
id: DOID:1731
in subset: NCIthesaurus

cryptosporidiosis
type: Class
subclass of: coccidiosis
subclass of: intestinal disease
textual definition: A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.
imported from: doid.owl
has_alternative_id: DOID:1732
has cross-reference: GARD:6219
has cross-reference: ICD10CM:A07.2
has cross-reference: ICD9CM:007.4
has cross-reference: MESH:D003457
has cross-reference: NCI:C128408
has cross-reference: SNOMEDCT_US_2020_03_01:186126003
has cross-reference: UMLS_CUI:C0010418
alternative_term: Cryptosporidial gastroenteritis
alternative_term: Infection by Cryptosporidium
alternative_term: intestinal cryptosporidiosis
has_obo_namespace: disease_ontology
id: DOID:1733
in subset: NCIthesaurus
in subset: zoonotic infectious disease

acanthoma
type: Class
subclass of: squamous cell neoplasm
imported from: doid.owl
has cross-reference: GARD:8604
has cross-reference: MESH:D049309
has cross-reference: NCI:C7419
has cross-reference: UMLS_CUI:C0846967
has_obo_namespace: disease_ontology
id: DOID:174
in subset: NCIthesaurus

drug psychosis
type: Class
subclass of: drug-induced mental disorder
imported from: doid.owl
has cross-reference: ICD9CM:292.1
has cross-reference: MESH:D011605
has cross-reference: SNOMEDCT_US_2020_03_01:191498001
has cross-reference: UMLS_CUI:C0033937
alternative_term: Drug-induced psychosis
alternative_term: Drug-induced psychotic disorder
has_obo_namespace: disease_ontology
id: DOID:1742

squamous cell carcinoma
type: Class
subclass of: carcinoma
textual definition: A carcinoma that derives_from squamous epithelial cells.
imported from: doid.owl
has_alternative_id: DOID:5512
has cross-reference: EFO:0000707
has cross-reference: GARD:1091
has cross-reference: MESH:D002294
has cross-reference: MESH:D018307
has cross-reference: NCI:C2929
has cross-reference: SNOMEDCT_US_2020_03_01:154605007
has cross-reference: UMLS_CUI:C0007137
has cross-reference: UMLS_CUI:C0751688
alternative_term: epidermoid carcinoma
alternative_term: malignant squamous cell tumor
alternative_term: squamous carcinoma
alternative_term: squamous cell Epithelioma
alternative_term: squamous cell cancer
has_obo_namespace: disease_ontology
id: DOID:1749
in subset: NCIthesaurus

vascular cancer
type: Class
subclass of: cardiovascular cancer
subclass of: vascular disease
textual definition: A cardiovascular cancer that is located_in blood vessels.
imported from: doid.owl
has_alternative_id: DOID:3339
has_alternative_id: DOID:5454
has_alternative_id: DOID:5548
has_alternative_id: DOID:7019
has_alternative_id: DOID:7020
has_alternative_id: DOID:7392
has cross-reference: MESH:D019043
has cross-reference: NCI:C5348
has cross-reference: NCI:C5380
has cross-reference: NCI:C5383
has cross-reference: NCI:C5388
has cross-reference: NCI:C7390
has cross-reference: SNOMEDCT_US_2020_03_01:126737003
has cross-reference: SNOMEDCT_US_2020_03_01:93817006
has cross-reference: UMLS_CUI:C0282607
has cross-reference: UMLS_CUI:C0346845
has cross-reference: UMLS_CUI:C1290407
has cross-reference: UMLS_CUI:C1334616
has cross-reference: UMLS_CUI:C1334617
has cross-reference: UMLS_CUI:C1334630
has cross-reference: UMLS_CUI:C1335753
alternative_term: Blood Vessel neoplasm
alternative_term: Blood vessel tumor
alternative_term: Blood vessel tumors
alternative_term: Blood vessel tumour disorder
alternative_term: Haemangiomatous tumour
alternative_term: blood vessel neoplasm
alternative_term: leiomyosarcoma of the renal Vein
alternative_term: malignant great vessel tumor
alternative_term: malignant tumor of pulmonary Vein
alternative_term: malignant tumor of pulmonary artery
alternative_term: malignant vascular neoplasm
alternative_term: malignant vascular tumor
alternative_term: neoplasm of great vessel
alternative_term: pulmonary artery malignant neoplasm
alternative_term: pulmonary vein malignant neoplasm
alternative_term: renal vein leiomyosarcoma
alternative_term: vascular tissue neoplasm
alternative_term: vascular tumors
has_obo_namespace: disease_ontology
id: DOID:175
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

mitral valve stenosis
type: Class
subclass of: mitral valve disease
textual definition: A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart.
imported from: doid.owl
has cross-reference: MESH:D008946
has cross-reference: NCI:C50654
has cross-reference: SNOMEDCT_US_2020_03_01:79619009
has cross-reference: UMLS_CUI:C0026269
alternative_term: Mitral stenosis
has_obo_namespace: disease_ontology
id: DOID:1754
in subset: NCIthesaurus

facial nerve disease
type: Class
subclass of: cranial nerve disease
imported from: doid.owl
has cross-reference: ICD10CM:G51
has cross-reference: ICD9CM:351
has cross-reference: MESH:D005155
has cross-reference: NCI:C27594
has cross-reference: SNOMEDCT_US_2020_03_01:90039006
has cross-reference: UMLS_CUI:C0015464
has_obo_namespace: disease_ontology
id: DOID:1756
in subset: NCIthesaurus

facial hemiatrophy
type: Class
subclass of: facial nerve disease
imported from: doid.owl
has cross-reference: MESH:D005150
has cross-reference: NCI:C84703
has cross-reference: OMIM:141300
has cross-reference: SNOMEDCT_US_2020_03_01:29868009
has cross-reference: UMLS_CUI:C0015458
alternative_term: PARRY-ROMBERG SYNDROME
has_obo_namespace: disease_ontology
id: DOID:1757
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cardiovascular cancer
type: Class
subclass of: organ system cancer
subclass of: cardiovascular system disease
textual definition: An organ system cancer that located_in the heart and blood vessels.
imported from: doid.owl
has cross-reference: NCI:C4784
has cross-reference: SNOMEDCT_US_2020_03_01:721573003
has cross-reference: UMLS_CUI:C0497243
alternative_term: Cardiovascular tumors
alternative_term: cardiovascular neoplasm
has_obo_namespace: disease_ontology
id: DOID:176
in subset: NCIthesaurus

Melkersson-Rosenthal syndrome
type: Class
subclass of: facial nerve disease
imported from: doid.owl
has cross-reference: GARD:7010
has cross-reference: ICD10CM:G51.2
has cross-reference: MESH:D008556
has cross-reference: NCI:C84886
has cross-reference: OMIM:155900
has cross-reference: SNOMEDCT_US_2020_03_01:2511001
has cross-reference: UMLS_CUI:C0025235
alternative_term: Cheilitis granulomatosa of Mescher-Melkersson-Rosenthal
alternative_term: Melkersson's syndrome
has_obo_namespace: disease_ontology
id: DOID:1761
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

toxic megacolon
type: Class
subclass of: megacolon
imported from: doid.owl
has cross-reference: ICD10CM:K59.31
has cross-reference: MESH:D008532
has cross-reference: SNOMEDCT_US_2020_03_01:28536002
has cross-reference: UMLS_CUI:C0025162
has_obo_namespace: disease_ontology
id: DOID:1770

vascular disease
type: Class
subclass of: cardiovascular system disease
textual definition: A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.
imported from: doid.owl
has_alternative_id: DOID:0000405
has_alternative_id: DOID:2403
has_alternative_id: DOID:2869
has_alternative_id: DOID:324
has_alternative_id: DOID:325
has_alternative_id: DOID:45
has cross-reference: ICD10CM:I72.9
has cross-reference: ICD9CM:442.9
has cross-reference: MESH:D000783
has cross-reference: MESH:D014652
has cross-reference: MESH:D020758
has cross-reference: MESH:D020760
has cross-reference: NCI:C26693
has cross-reference: NCI:C35117
has cross-reference: SNOMEDCT_US_2020_03_01:27550009
has cross-reference: SNOMEDCT_US_2020_03_01:371029002
has cross-reference: SNOMEDCT_US_2020_03_01:432119003
has cross-reference: UMLS_CUI:C0002940
has cross-reference: UMLS_CUI:C0042373
has cross-reference: UMLS_CUI:C0752127
has cross-reference: UMLS_CUI:C0752130
alternative_term: vascular tissue disease
has_obo_namespace: disease_ontology
id: DOID:178
in subset: NCIthesaurus

thyroid gland cancer
type: Class
subclass of: endocrine gland cancer
subclass of: thyroid gland disease
textual definition: An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.
imported from: doid.owl
has_alternative_id: DOID:10008
has cross-reference: ICD10CM:C73
has cross-reference: ICD9CM:193
has cross-reference: KEGG:05216
has cross-reference: MESH:D013964
has cross-reference: NCI:C3414
has cross-reference: NCI:C7510
has cross-reference: SNOMEDCT_US_2020_03_01:127018007
has cross-reference: SNOMEDCT_US_2020_03_01:94098005
has cross-reference: UMLS_CUI:C0007115
has cross-reference: UMLS_CUI:C0040136
alternative_term: Thyroid gland neoplasm
alternative_term: malignant neoplasm of thyroid gland
alternative_term: malignant tumour of thyroid gland
alternative_term: neoplasm of thyroid gland
alternative_term: thyroid neoplasm
has_obo_namespace: disease_ontology
id: DOID:1781
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

pituitary cancer
type: Class
subclass of: endocrine gland cancer
subclass of: pituitary gland disease
textual definition: An endocrine gland cancer located_in the pituitary gland located at the base of the brain.
imported from: doid.owl
has_alternative_id: DOID:5671
has cross-reference: GARD:9371
has cross-reference: ICD10CM:C75.1
has cross-reference: MESH:D010911
has cross-reference: NCI:C3330
has cross-reference: NCI:C4769
has cross-reference: SNOMEDCT_US_2020_03_01:127024001
has cross-reference: SNOMEDCT_US_2020_03_01:93964007
has cross-reference: UMLS_CUI:C0032019
has cross-reference: UMLS_CUI:C0496842
alternative_term: Pituitary gland neoplasm
alternative_term: malignant Pituitary neoplasm
alternative_term: malignant tumor of pituitary gland
alternative_term: neoplasm of pituitary gland
alternative_term: pituitary gland cancer
alternative_term: pituitary neoplasm
has_obo_namespace: disease_ontology
id: DOID:1785
in subset: NCIthesaurus

adrenal rest tumor
type: Class
subclass of: endocrine organ benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D000314
has cross-reference: NCI:C2860
has cross-reference: SNOMEDCT_US_2020_03_01:54292009
has cross-reference: UMLS_CUI:C0001630
alternative_term: Adrenal Rest neoplasm
has_obo_namespace: disease_ontology
id: DOID:1786
in subset: NCIthesaurus

pericarditis
type: Class
subclass of: pericardium disease
textual definition: A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.
imported from: doid.owl
has cross-reference: MESH:D010493
has cross-reference: NCI:C34915
has cross-reference: SNOMEDCT_US_2020_03_01:3238004
has cross-reference: UMLS_CUI:C0031046
has_obo_namespace: disease_ontology
id: DOID:1787
in subset: NCIthesaurus

peritoneal mesothelioma
type: Class
subclass of: peritoneum cancer
subclass of: squamous cell carcinoma
textual definition: A peritoneum cancer that develops from cells of the mesothelium and is located_in the peritoneum.
imported from: doid.owl
has_alternative_id: DOID:0050874
has_alternative_id: DOID:7954
has cross-reference: ICD10CM:C45.1
has cross-reference: NCI:C8704
has cross-reference: NCI:C9350
has cross-reference: SNOMEDCT_US_2020_03_01:187806007
has cross-reference: UMLS_CUI:C0346109
has cross-reference: UMLS_CUI:C0854886
alternative_term: Advanced malignant Mesothelioma of Peritoneum
alternative_term: advanced malignant peritoneal mesothelioma
alternative_term: malignant mesothelioma of peritoneum
has_obo_namespace: disease_ontology
id: DOID:1788
in subset: DO cancer slim
in subset: NCIthesaurus

malignant mesothelioma
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in mesothelial tissue that develops from the thin layer of tissue that covers many of the internal organs.
imported from: doid.owl
has_alternative_id: DOID:4487
has_alternative_id: DOID:6965
has_alternative_id: DOID:7434
has cross-reference: MESH:C562839
has cross-reference: NCI:C27926
has cross-reference: NCI:C4456
has cross-reference: NCI:C7865
has cross-reference: NCI:C8420
has cross-reference: OMIM:156240
has cross-reference: SNOMEDCT_US_2020_03_01:109378008
has cross-reference: UMLS_CUI:C0278752
has cross-reference: UMLS_CUI:C0345967
has cross-reference: UMLS_CUI:C0392400
has cross-reference: UMLS_CUI:C1332338
alternative_term: Diffuse malignant Mesothelioma
alternative_term: advanced malignant mesothelioma
alternative_term: asbestos-related malignant mesothelioma
alternative_term: malignant tumor of Mesothelium
has_obo_namespace: disease_ontology
id: DOID:1790
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

peritoneal carcinoma
type: Class
subclass of: peritoneum cancer
subclass of: carcinoma
subclass of: gastrointestinal system cancer
textual definition: A carcinoma that is located_in the inside of the abdomen.
imported from: doid.owl
has cross-reference: NCI:C40022
has cross-reference: UMLS_CUI:C1514428
alternative_term: primary peritoneal carcinoma
has_obo_namespace: disease_ontology
id: DOID:1791
in subset: NCIthesaurus

pancreatic cancer
type: Class
subclass of: endocrine gland cancer
subclass of: pancreas disease
textual definition: An endocrine gland cancer located_in the pancreas.
imported from: doid.owl
has_alternative_id: DOID:14356
has_alternative_id: DOID:1797
has_alternative_id: DOID:3588
has_alternative_id: DOID:9859
has cross-reference: GARD:9364
has cross-reference: ICD10CM:C25.0
has cross-reference: ICD10CM:C25.1
has cross-reference: ICD10CM:C25.2
has cross-reference: ICD9CM:157.0
has cross-reference: ICD9CM:157.1
has cross-reference: ICD9CM:157.2
has cross-reference: ICD9CM:157.8
has cross-reference: KEGG:05212
has cross-reference: MESH:D010190
has cross-reference: NCI:C3305
has cross-reference: ORDO:1333
has cross-reference: ORDO:217074
has cross-reference: SNOMEDCT_US_2020_03_01:126859007
has cross-reference: SNOMEDCT_US_2020_03_01:187796007
has cross-reference: SNOMEDCT_US_2020_03_01:93715005
has cross-reference: SNOMEDCT_US_2020_03_01:93823001
has cross-reference: SNOMEDCT_US_2020_03_01:94082003
has cross-reference: UMLS_CUI:C0030297
has cross-reference: UMLS_CUI:C0153458
has cross-reference: UMLS_CUI:C0153459
has cross-reference: UMLS_CUI:C0153460
has cross-reference: UMLS_CUI:C0153463
alternative_term: Ca body of pancreas
alternative_term: Ca head of pancreas
alternative_term: Ca tail of pancreas
alternative_term: malignant neoplasm of body of pancreas
alternative_term: malignant neoplasm of head of pancreas
alternative_term: malignant neoplasm of tail of pancreas
alternative_term: pancreas neoplasm
alternative_term: pancreatic neoplasm
alternative_term: pancreatic tumor
has_obo_namespace: disease_ontology
id: DOID:1793
in subset: DO rare slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: Xref MGI.

malignant exocrine pancreas neoplasm
type: Class
subclass of: pancreatic cancer
textual definition: A pancreatic cancer that arises from the epithelial cells of the exocrine pancreatic tissue.
imported from: doid.owl
has_alternative_id: DOID:1794
has cross-reference: NCI:C7430
has cross-reference: SNOMEDCT_US_2020_03_01:255088001
has cross-reference: UMLS_CUI:C0346648
alternative_term: malignant neoplasm of the Exocrine pancreas
alternative_term: malignant tumor of exocrine pancreas
alternative_term: malignant tumour of exocrine pancreas
has_obo_namespace: disease_ontology
id: DOID:1795
in subset: NCIthesaurus

pancreatic endocrine carcinoma
type: Class
subclass of: islet cell tumor
textual definition: An islet cell tumor that has_material_basis_in epithelial cells.
imported from: doid.owl
has cross-reference: GARD:13034
has cross-reference: ICD10CM:C25.4
has cross-reference: ICD9CM:157.4
has cross-reference: MESH:D018273
has cross-reference: NCI:C3770
has cross-reference: SNOMEDCT_US_2020_03_01:254612002
has cross-reference: UMLS_CUI:C1328479
alternative_term: Islet cell carcinoma
alternative_term: carcinoma of endocrine pancreas
alternative_term: malignant neoplasm of islets of Langerhans
alternative_term: pancreatic neuroendocrine carcinoma
has_obo_namespace: disease_ontology
id: DOID:1798
in subset: DO cancer slim
in subset: NCIthesaurus

islet cell tumor
type: Class
subclass of: pancreatic cancer
textual definition: A pancreatic cancer that is located_in the pancreatic islet cells.
imported from: doid.owl
has_alternative_id: DOID:10165
has cross-reference: ICD10CM:C25.4
has cross-reference: ICD10CM:D13.7
has cross-reference: MESH:D007516
has cross-reference: NCI:C27031
has cross-reference: SNOMEDCT_US_2020_03_01:254611009
has cross-reference: SNOMEDCT_US_2020_03_01:261713004
has cross-reference: UMLS_CUI:C0242363
has cross-reference: UMLS_CUI:C0496784
alternative_term: Islet cell neoplasm
alternative_term: Islet cell tumor
alternative_term: Islet cell tumour
alternative_term: endocrine pancreas cancer
alternative_term: islet cell tumour
alternative_term: malignant pancreatic Endocrine tumor
alternative_term: malignant pancreatic Endocrine tumour
alternative_term: malignant tumor of endocrine pancreas
alternative_term: malignant tumour of endocrine pancreas
alternative_term: pancreatic Endocrine neoplasm
has_obo_namespace: disease_ontology
id: DOID:1799
in subset: NCIthesaurus

urinary system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.
imported from: doid.owl
has_alternative_id: DOID:579
has cross-reference: NCI:C27599
has cross-reference: UMLS_CUI:C1335051
alternative_term: Non-neoplastic urinary tract disease
alternative_term: urinary tract disease
has_obo_namespace: disease_ontology
id: DOID:18
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

ossifying fibroma
type: Class
subclass of: bone benign neoplasm
textual definition: A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.
imported from: doid.owl
has cross-reference: MESH:D018214
has cross-reference: NCI:C8422
has cross-reference: SNOMEDCT_US_2020_03_01:189896007
has cross-reference: UMLS_CUI:C0206640
alternative_term: Fibro-osteoma
has_obo_namespace: disease_ontology
has_related_synonym: peripheral ossifying fibroma
id: DOID:180
in subset: NCIthesaurus

neuroendocrine carcinoma
type: Class
subclass of: carcinoma
textual definition: A carcinoma that derives_from neuroendocrine cells.
imported from: doid.owl
has cross-reference: MESH:D018278
has cross-reference: NCI:C3773
has cross-reference: SNOMEDCT_US_2020_03_01:55937004
has cross-reference: UMLS_CUI:C0206695
has_obo_namespace: disease_ontology
id: DOID:1800
in subset: NCIthesaurus

mononeuritis
type: Class
subclass of: mononeuropathy
imported from: doid.owl
has cross-reference: ICD9CM:355.9
has cross-reference: MESH:D020422
has cross-reference: SNOMEDCT_US_2020_03_01:32595002
has cross-reference: UMLS_CUI:C0235880
has_obo_namespace: disease_ontology
id: DOID:1802

neuritis
type: Class
subclass of: DOID 870
imported from: doid.owl
has cross-reference: MESH:D009443
has cross-reference: NCI:C116381
has cross-reference: SNOMEDCT_US_2020_03_01:247378004
has cross-reference: UMLS_CUI:C0027813
alternative_term: peripheral neuritis
has_obo_namespace: disease_ontology
id: DOID:1803
in subset: NCIthesaurus

reflex sympathetic dystrophy
type: Class
subclass of: complex regional pain syndrome
imported from: doid.owl
has cross-reference: ICD10CM:G90.5
has cross-reference: ICD9CM:337.2
has cross-reference: MESH:D012019
has cross-reference: NCI:C85042
has cross-reference: OMIM:604335
has cross-reference: SNOMEDCT_US_2020_03_01:203492008
has cross-reference: UMLS_CUI:C0034931
has_obo_namespace: disease_ontology
id: DOID:1811
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

calcinosis
type: Class
subclass of: calcium metabolism disease
textual definition: A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.
imported from: doid.owl
has cross-reference: MESH:D002114
has cross-reference: NCI:C3672
has cross-reference: SNOMEDCT_US_2020_03_01:237881004
has cross-reference: UMLS_CUI:C0006663
alternative_term: Pathologically calcified structure
alternative_term: pathologic calcification
has_obo_namespace: disease_ontology
id: DOID:182
in subset: NCIthesaurus

childhood absence epilepsy
type: Class
subclass of: childhood electroclinical syndrome
textual definition: A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.
imported from: doid.owl
has cross-reference: MESH:D004832
has cross-reference: NCI:C3023
has cross-reference: SNOMEDCT_US_2020_03_01:163596002
has cross-reference: UMLS_CUI:C0014553
alternative_term: petit mal seizure
alternative_term: pyknolepsy
has_obo_namespace: disease_ontology
has_related_synonym: absence seizure
id: DOID:1825
in subset: NCIthesaurus

epilepsy
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.
imported from: doid.owl
has cross-reference: EFO:0000474
has cross-reference: ICD10CM:G40.909
has cross-reference: ICD9CM:345.9
has cross-reference: MESH:D004827
has cross-reference: NCI:C3020
has cross-reference: SNOMEDCT_US_2020_03_01:267698007
has cross-reference: UMLS_CUI:C0014544
alternative_term: epilepsy syndrome
alternative_term: epileptic syndrome
has_obo_namespace: disease_ontology
id: DOID:1826
in subset: DO FlyBase slim
in subset: NCIthesaurus

idiopathic generalized epilepsy
type: Class
subclass of: epilepsy
textual definition: An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain.
imported from: doid.owl
has cross-reference: MESH:D004829
has cross-reference: NCI:C3021
has cross-reference: OMIM:600669
has cross-reference: SNOMEDCT_US_2020_03_01:155043003
has cross-reference: UMLS_CUI:C0014548
alternative_term: Generalised epilepsy
has_obo_namespace: disease_ontology
id: DOID:1827
in subset: NCIthesaurus
comment: Xref MGI.

urethral stricture
type: Class
subclass of: urethral obstruction
imported from: doid.owl
has cross-reference: ICD9CM:598.8
has cross-reference: UMLS_CUI:C0029752
has_obo_namespace: disease_ontology
id: DOID:1829

Menkes disease
type: Class
subclass of: DOID 896
imported from: doid.owl
has cross-reference: GARD:1521
has cross-reference: MESH:D007706
has cross-reference: NCI:C75486
has cross-reference: OMIM:309400
has cross-reference: SNOMEDCT_US_2020_03_01:59178007
has cross-reference: UMLS_CUI:C0022716
alternative_term: COPPER TRANSPORT DISEASE
alternative_term: Menkes kinky-hair syndrome
alternative_term: steely hair syndrome
has_obo_namespace: disease_ontology
id: DOID:1838
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

bone cancer
type: Class
subclass of: bone disease
subclass of: connective tissue cancer
textual definition: A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.
imported from: doid.owl
has_alternative_id: DOID:3348
has cross-reference: MESH:D001859
has cross-reference: NCI:C9343
has cross-reference: SNOMEDCT_US_2020_03_01:126537000
has cross-reference: UMLS_CUI:C0005967
alternative_term: CA - bone cancer
alternative_term: bone neoplasm
alternative_term: bone tumour
alternative_term: malignant bone neoplasm
alternative_term: malignant bone tumour
alternative_term: malignant neoplasm of bone
alternative_term: malignant osseous tumor
alternative_term: neoplasm of bone
alternative_term: osseous tumor
has_obo_namespace: disease_ontology
id: DOID:184
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

cannabis dependence
type: Class
subclass of: DOID 9977
textual definition: A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.
imported from: doid.owl
has cross-reference: ICD10CM:F12.2
has cross-reference: ICD9CM:304.3
has cross-reference: MESH:D002189
has cross-reference: NCI:C34445
has cross-reference: SNOMEDCT_US_2020_03_01:268766005
has cross-reference: UMLS_CUI:C0006870
has_obo_namespace: disease_ontology
id: DOID:1849
in subset: NCIthesaurus

intrahepatic cholestasis
type: Class
subclass of: cholestasis
textual definition: A cholestasis characterized by impairment of the bile flow caused by obstruction located_in liver.
imported from: doid.owl
has cross-reference: GARD:10214
has cross-reference: MESH:D002780
has cross-reference: NCI:C84400
has cross-reference: ORDO:284385
has cross-reference: SNOMEDCT_US_2020_03_01:4637005
has cross-reference: UMLS_CUI:C0008372
alternative_term: neonatal intrahepatic cholestasis
has_obo_namespace: disease_ontology
id: DOID:1852
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

cherubism
type: Class
subclass of: autosomal dominant disease
subclass of: skin disease
textual definition: A bone disease characterized by replacement of bone in the jaws with fibrous tissue leding to facial swelling that has_material_basis_in heterozygous mutation in SH3BP2 on chromosome 4p16.3.
imported from: doid.owl
has cross-reference: GARD:6036
has cross-reference: ICD10CM:M27.8
has cross-reference: MESH:D002636
has cross-reference: NCI:C84630
has cross-reference: OMIM:118400
has cross-reference: SNOMEDCT_US_2020_03_01:76098004
has cross-reference: UMLS_CUI:C0008029
has_obo_namespace: disease_ontology
id: DOID:1856
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

McCune Albright syndrome
type: Class
subclass of: autosomal genetic disease
subclass of: syndrome
textual definition: A syndrome that is characterized by polyostotic fibrous dysplasia, precocious puberty, and café-au-lait spots and has_material_basis_in spontaneous post zygotic missense mutation at ARG201 or Gln227 of the GNAS gene during embryogenesis.
imported from: doid.owl
has_alternative_id: DOID:11345
has cross-reference: GARD:6995
has cross-reference: ICD10CM:Q78.1
has cross-reference: ICD9CM:756.54
has cross-reference: NCI:C34610
has cross-reference: OMIM:174800
has cross-reference: SNOMEDCT_US_2020_03_01:726029005
has cross-reference: UMLS_CUI:C0016065
alternative_term: fibrous dysplasia of bone
alternative_term: osteitis fibrosa disseminata
alternative_term: polyostotic fibrous dysplasia
has_obo_namespace: disease_ontology
id: DOID:1858
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

jaw cancer
type: Class
subclass of: bone cancer
textual definition: A bone cancer and jaw disease that is located in the jaw and results in a swollen jaw, results in numbness or a tingling sensation in jaw, and results in an abnormal growth of the jaw bone.
imported from: doid.owl
has cross-reference: MESH:D007573
has cross-reference: SNOMEDCT_US_2020_03_01:126634001
has cross-reference: UMLS_CUI:C0022364
alternative_term: neoplasm of jaw
has_obo_namespace: disease_ontology
has_related_synonym: jaw neoplasm
id: DOID:1862

skull cancer
type: Class
subclass of: bone cancer
imported from: doid.owl
has cross-reference: MESH:D012888
has cross-reference: NCI:C3375
has cross-reference: SNOMEDCT_US_2020_03_01:126538005
has cross-reference: UMLS_CUI:C0037305
has_obo_namespace: disease_ontology
id: DOID:1863
in subset: NCIthesaurus

giant cell reparative granuloma
type: Class
subclass of: bone giant cell tumor
imported from: doid.owl
has cross-reference: ICD10CM:M27.1
has cross-reference: ICD9CM:526.3
has cross-reference: MESH:D006101
has cross-reference: SNOMEDCT_US_2020_03_01:15350006
has cross-reference: UMLS_CUI:C0162375
alternative_term: central giant cell (reparative) granuloma
alternative_term: central giant cell granuloma
alternative_term: central giant cell reparative granuloma of jaw
has_obo_namespace: disease_ontology
id: DOID:1866

impotence
type: Class
subclass of: sexual dysfunction
imported from: doid.owl
has cross-reference: EFO:0004234
alternative_term: Sexual impotence
alternative_term: erectile dysfunction
has_obo_namespace: disease_ontology
id: DOID:1875

sexual dysfunction
type: Class
subclass of: sexual disorder
imported from: doid.owl
has cross-reference: ICD10CM:F52.9
has cross-reference: NCI:C3347
has cross-reference: SNOMEDCT_US_2020_03_01:39894007
has cross-reference: UMLS_CUI:C0549622
has_obo_namespace: disease_ontology
id: DOID:1876
in subset: NCIthesaurus

atrial heart septal defect
type: Class
subclass of: heart septal defect
textual definition: A heart septal defect located_in in the septum that separates the two atria of the heart.
imported from: doid.owl
has cross-reference: ICD10CM:Q21.1
has cross-reference: MESH:D006344
has cross-reference: NCI:C84473
has cross-reference: OMIM:PS108800
has cross-reference: ORDO:1478
has cross-reference: SNOMEDCT_US_2020_03_01:156915002
has cross-reference: UMLS_CUI:C0018817
alternative_term: atrial septal defect
alternative_term: atrioseptal defect
alternative_term: auricular septal defect
alternative_term: congenital atrial septal defect
alternative_term: interatrial septal defect
alternative_term: interauricular septal defect
has_obo_namespace: disease_ontology
id: DOID:1882
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

hepatitis C
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.
imported from: doid.owl
has_alternative_id: DOID:12430
has_alternative_id: DOID:12432
has_alternative_id: DOID:2049
has cross-reference: EFO:0003047
has cross-reference: ICD10CM:B19.20
has cross-reference: ICD9CM:070.7
has cross-reference: MESH:D006526
has cross-reference: NCI:C3098
has cross-reference: SNOMEDCT_US_2020_03_01:154349000
has cross-reference: UMLS_CUI:C0019196
alternative_term: NANBH
alternative_term: Viral hepatitis C
alternative_term: chronic hepatitis C
alternative_term: hepatitis C infection
alternative_term: hepatitis nonA nonB
has_obo_namespace: disease_ontology
id: DOID:1883
in subset: NCIthesaurus

viral hepatitis
type: Class
subclass of: hepatitis
subclass of: DOID 934
textual definition: A hepatitis that involves viral infection causing inflammation of the liver.
imported from: doid.owl
has_alternative_id: DOID:12548
has_alternative_id: DOID:1331
has_alternative_id: DOID:1885
has cross-reference: MESH:D006524
has cross-reference: UMLS_CUI:C0019194
alternative_term: Viral hepatitis with hepatic coma
alternative_term: animal viral hepatitis
alternative_term: human viral hepatitis
has_obo_namespace: disease_ontology
id: DOID:1884

optic nerve disease
type: Class
subclass of: cranial nerve disease
textual definition: A cranial nerve disease that is located_in the optic nerve.
imported from: doid.owl
has cross-reference: MESH:D009901
has cross-reference: NCI:C79698
has cross-reference: SNOMEDCT_US_2020_03_01:77157004
has cross-reference: UMLS_CUI:C0029132
alternative_term: disorder of the second nerve
alternative_term: optic nerve disorder
alternative_term: optic neuropathy
has_obo_namespace: disease_ontology
id: DOID:1891
in subset: NCIthesaurus

malignant fibrous histiocytoma
type: Class
subclass of: sarcoma
imported from: doid.owl
has cross-reference: MESH:D051677
has cross-reference: NCI:C4247
has cross-reference: SNOMEDCT_US_2020_03_01:34360000
has cross-reference: UMLS_CUI:C0334463
alternative_term: Fibroxanthosarcoma
alternative_term: MFH
has_obo_namespace: disease_ontology
id: DOID:1907
in subset: NCIthesaurus

melanoma
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.
imported from: doid.owl
has cross-reference: EFO:0000756
has cross-reference: KEGG:05218
has cross-reference: MESH:D008545
has cross-reference: NCI:C3224
has cross-reference: SNOMEDCT_US_2020_03_01:2092003
has cross-reference: UMLS_CUI:C0025202
alternative_term: Naevocarcinoma
alternative_term: malignant melanoma
has_obo_namespace: disease_ontology
id: DOID:1909
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

endodermal sinus tumor
type: Class
subclass of: germ cell cancer
textual definition: A germ cell cancer that has_material_basis_in cells that line the yolk sac of the embryo.
imported from: doid.owl
has cross-reference: MESH:D018240
has cross-reference: NCI:C3011
has cross-reference: SNOMEDCT_US_2020_03_01:74409009
has cross-reference: UMLS_CUI:C0014145
alternative_term: Hepatoid yolk sac tumour
alternative_term: Yolk Sac neoplasm
alternative_term: Yolk sac tumor
alternative_term: Yolk sac tumour
alternative_term: endodermal sinus tumour
alternative_term: infantile embryonal carcinoma
has_obo_namespace: disease_ontology
id: DOID:1911
in subset: NCIthesaurus

Lesch-Nyhan syndrome
type: Class
subclass of: X-linked recessive disease
subclass of: purine-pyrimidine metabolic disorder
imported from: doid.owl
has cross-reference: ICD10CM:E79.1
has cross-reference: MESH:D007926
has cross-reference: NCI:C61255
has cross-reference: OMIM:300322
has cross-reference: SNOMEDCT_US_2020_03_01:190918000
has cross-reference: UMLS_CUI:C0023374
alternative_term: Complete hypoxanthine-guanine phosphoribosyltransferase deficiency
alternative_term: HG-PRT deficiency
alternative_term: Hypoxanthine-guanine phosphoribosyltransferase deficiency
alternative_term: Hypoxanthine-guanine-phosphoribosyltransferase deficiency
alternative_term: Lesch - Nyhan syndrome
alternative_term: X-linked hyperuricemia
alternative_term: deficiency of IMP pyrophosphorylase
alternative_term: hypoxanthine guanine phosphoribosyltransferase deficiency
has_obo_namespace: disease_ontology
id: DOID:1919
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

sex cord-gonadal stromal tumor
type: Class
subclass of: reproductive organ cancer
textual definition: A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary or testis and derives_from granulosa cells, Leydig cells, Sertoli cells, and fibroblasts.
imported from: doid.owl
has_alternative_id: DOID:12293
has cross-reference: MESH:D018312
has cross-reference: NCI:C3794
has cross-reference: SNOMEDCT_US_2020_03_01:253028001
has cross-reference: UMLS_CUI:C0206724
alternative_term: Sex Cord-Stromal neoplasm
alternative_term: Sex cord stromal tumour
alternative_term: Specialized gonadal neoplasm
alternative_term: Specialized gonadal tumor
alternative_term: Specialized gonadal tumour
alternative_term: sex cord-gonadal stromal tumour
has_obo_namespace: disease_ontology
id: DOID:192
in subset: NCIthesaurus

hyperuricemia
type: Class
subclass of: acquired metabolic disease
textual definition: An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood.
imported from: doid.owl
has cross-reference: MESH:D033461
has cross-reference: NCI:C3961
has cross-reference: SNOMEDCT_US_2020_03_01:271198001
has cross-reference: UMLS_CUI:C0740394
alternative_term: Blood urate raized
alternative_term: uricacidemia
has_obo_namespace: disease_ontology
id: DOID:1920
in subset: NCIthesaurus

Klinefelter syndrome
type: Class
subclass of: chromosomal duplication syndrome
textual definition: A chromosomal duplication syndrome that is characterized by infertility and that has_material_basis_in an extra X chromosome in cells in men.
imported from: doid.owl
has cross-reference: GARD:8705
has cross-reference: ICD10CM:Q98.0
has cross-reference: ICD9CM:758.7
has cross-reference: MESH:D007713
has cross-reference: NCI:C34752
has cross-reference: SNOMEDCT_US_2020_03_01:405770005
has cross-reference: UMLS_CUI:C0022735
alternative_term: 47, XXY
alternative_term: Hypogonadotropic Hypogonadism
alternative_term: Klinefelter's syndrome
alternative_term: XXY syndrome
alternative_term: XXY trisomy
has_obo_namespace: disease_ontology
id: DOID:1921
in subset: NCIthesaurus
comment: No OMIM mapping, confirmed by DO. [LS].

disorder of sexual development
type: Class
subclass of: gonadal disease
textual definition: A gonadal disease that is characterized by atypical development of chromosomal, gonadal, or anatomic sex.
imported from: doid.owl
has cross-reference: MESH:D012734
has cross-reference: UMLS_CUI:C0036875
alternative_term: sex development disorder
alternative_term: sex differentiation disease
has_obo_namespace: disease_ontology
id: DOID:1923

hypogonadism
type: Class
subclass of: gonadal disease
textual definition: A gonadal disease that is characterized by diminished functional activity of the gonads.
imported from: doid.owl
has cross-reference: MESH:D007006
has cross-reference: NCI:C9227
has cross-reference: OMIM:241100
has cross-reference: OMIM:312300
has cross-reference: SNOMEDCT_US_2020_03_01:48130008
has cross-reference: UMLS_CUI:C0020619
has_obo_namespace: disease_ontology
id: DOID:1924
in subset: NCIthesaurus

Coffin-Siris syndrome
type: Class
subclass of: autosomal dominant non-syndromic intellectual disability
subclass of: syndrome
textual definition: An autosomal dominant non-syndromic intellectual disability that is characterized by mental retardation associated with coarse facial features, hypertrichosis, sparse scalp hair, and hypoplastic or absent fifth fingernails or toenails.
imported from: doid.owl
has cross-reference: GARD:6124
has cross-reference: MESH:C536436
has cross-reference: NCI:C35321
has cross-reference: OMIM:PS135900
has cross-reference: ORDO:1465
has cross-reference: SNOMEDCT_US_2020_03_01:10007009
has cross-reference: UMLS_CUI:C0265338
alternative_term: Dwarfism-Onychodysplasia
alternative_term: Fifth Digit Syndrome
alternative_term: Short Stature-Onychodysplasia.
has_obo_namespace: disease_ontology
id: DOID:1925
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Gaucher's disease
type: Class
subclass of: sphingolipidosis
textual definition: A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver.
imported from: doid.owl
has cross-reference: GARD:8233
has cross-reference: ICD10CM:E75.22
has cross-reference: MESH:D005776
has cross-reference: NCI:C61268
has cross-reference: ORDO:355
has cross-reference: SNOMEDCT_US_2020_03_01:190794006
has cross-reference: UMLS_CUI:C0017205
alternative_term: Gaucher disease
alternative_term: acid beta-glucosidase deficiency
alternative_term: glocucerebrosidase deficiency
alternative_term: glucosylceramide beta-glucosidase deficiency
alternative_term: kerasin thesaurismosis
has_obo_namespace: disease_ontology
id: DOID:1926
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

sphingolipidosis
type: Class
subclass of: DOID 9455
textual definition: A lipid storage disease characterized by functional deficiencies in the enzymes needed for lysosomal degradation of sphingolipid substrates.
imported from: doid.owl
has cross-reference: GARD:7672
has cross-reference: ICD10CM:E75.3
has cross-reference: MESH:D013106
has cross-reference: NCI:C117254
has cross-reference: SNOMEDCT_US_2020_03_01:58459009
has cross-reference: UMLS_CUI:C0037899
alternative_term: Sphingolipidosis
alternative_term: sphingolipidoses
has_obo_namespace: disease_ontology
id: DOID:1927
in subset: NCIthesaurus

Williams-Beuren syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: chromosomal deletion syndrome
subclass of: syndrome
textual definition: A syndrome that is characterized by mild to moderate intellectual disability, a broad forehead, a short nose with a broad tip, full cheeks, and a wide mouth with full lips and difficulty with visual-spatial tasks and has_material_basis_in hemizygous deletion of 1.5 to 1.8 Mb on chromosome 7q11.23.
imported from: doid.owl
has cross-reference: ICD10CM:Q93.82
has cross-reference: MESH:D018980
has cross-reference: NCI:C85232
has cross-reference: OMIM:194050
has cross-reference: SNOMEDCT_US_2020_03_01:63247009
has cross-reference: UMLS_CUI:C0175702
alternative_term: Fanconi Schlesinger syndrome
has_obo_namespace: disease_ontology
id: DOID:1928
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

supravalvular aortic stenosis
type: Class
subclass of: aortic valve stenosis
textual definition: An aortic valve stenosis that is characterized by a narrowing of the section of the aorta just above the valve that connects the aorta to the heart.
imported from: doid.owl
has cross-reference: GARD:743
has cross-reference: ICD10CM:Q25.3
has cross-reference: MESH:D021921
has cross-reference: NCI:C85176
has cross-reference: OMIM:185500
has cross-reference: SNOMEDCT_US_2020_03_01:204436002
has cross-reference: UMLS_CUI:C0003499
alternative_term: Supra-valvular aortic stenosis
has_obo_namespace: disease_ontology
id: DOID:1929
in subset: NCIthesaurus

reproductive organ cancer
type: Class
subclass of: organ system cancer
subclass of: reproductive system disease
textual definition: An organ system cancer that is manifested in the reproductive organs.
imported from: doid.owl
has_alternative_id: DOID:1900
has cross-reference: NCI:C3674
has cross-reference: UMLS_CUI:C0178830
alternative_term: Reproductive tumor
alternative_term: malignant reproductive system neoplasm
has_obo_namespace: disease_ontology
has_related_synonym: cancer of reproductive system
id: DOID:193
in subset: NCIthesaurus

Laurence-Moon syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by pituitary dysfunction, childhood onset ataxia, peripheral neuropathy, spastic paraplegia, and chorioretinopathy that has_material_basis_in homozygous or compound heterozygous mutation in PNPLA6 on chromosome 19p13.2.
imported from: doid.owl
has cross-reference: GARD:12635
has cross-reference: MEDDRA:10056710
has cross-reference: MESH:D007849
has cross-reference: NCI:C34760
has cross-reference: OMIM:245800
has cross-reference: ORDO:2377
has cross-reference: SNOMEDCT_US_2020_03_01:232059000
has cross-reference: UMLS_CUI:C0023138
alternative_term: LNMS
has_obo_namespace: disease_ontology
has_related_synonym: Laurence-Moon-Biedl syndrome
id: DOID:1930
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Angelman syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by delayed development, intellectual disability, severe speech impairment, and problems with movement and balance.
imported from: doid.owl
has cross-reference: GARD:5810
has cross-reference: ICD10CM:Q93.51
has cross-reference: MESH:D017204
has cross-reference: NCI:C75462
has cross-reference: OMIM:105830
has cross-reference: SNOMEDCT_US_2020_03_01:76880004
has cross-reference: UMLS_CUI:C0162635
alternative_term: happy puppet syndrome
alternative_term: puppetlike syndrome
has_obo_namespace: disease_ontology
id: DOID:1932
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Rubinstein-Taybi syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: chromosomal deletion syndrome
subclass of: syndrome
textual definition: A syndrome characterized by short stature, moderate to sever intellectual disability, distinctive facial features and broad thumbs and first toes.
imported from: doid.owl
has cross-reference: GARD:7593
has cross-reference: ICD10CM:Q87.2
has cross-reference: MESH:D012415
has cross-reference: NCI:C75466
has cross-reference: OMIM:180849
has cross-reference: OMIM:610543
has cross-reference: OMIM:613684
has cross-reference: ORDO:783
has cross-reference: SNOMEDCT_US_2020_03_01:157032007
has cross-reference: UMLS_CUI:C0035934
alternative_term: Broad Thumb-Hallux syndrome
alternative_term: Rubinstein syndrome
alternative_term: proximal chromosome 16p13.3 deletion syndrome
has_obo_namespace: disease_ontology
id: DOID:1933
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

dysostosis
type: Class
subclass of: bone development disease
textual definition: A bone development disease that results in defective ossification of located in bone.
imported from: doid.owl
has cross-reference: MESH:D004413
has cross-reference: NCI:C34560
has cross-reference: SNOMEDCT_US_2020_03_01:109420003
has cross-reference: UMLS_CUI:C0013393
has_obo_namespace: disease_ontology
id: DOID:1934
in subset: NCIthesaurus

Bardet-Biedl syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, hypogonadism, and renal failure in some cases.
imported from: doid.owl
has cross-reference: GARD:6866
has cross-reference: ICD10CM:Q87.89
has cross-reference: MESH:D020788
has cross-reference: NCI:C118632
has cross-reference: OMIM:PS209900
has cross-reference: ORDO:110
has cross-reference: SNOMEDCT_US_2020_03_01:5619004
has cross-reference: UMLS_CUI:C0752166
has_obo_namespace: disease_ontology
id: DOID:1935
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

atherosclerosis
type: Class
subclass of: arteriosclerotic cardiovascular disease
imported from: doid.owl
has cross-reference: EFO:0003914
has cross-reference: ICD10CM:I70
has cross-reference: ICD9CM:440
has cross-reference: MESH:D050197
has cross-reference: NCI:C35768
has cross-reference: SNOMEDCT_US_2020_03_01:155414001
has cross-reference: UMLS_CUI:C0004153
has_obo_namespace: disease_ontology
id: DOID:1936
in subset: NCIthesaurus

trichomoniasis
type: Class
subclass of: parasitic protozoa infectious disease
textual definition: A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.
imported from: doid.owl
has_alternative_id: DOID:10996
has cross-reference: ICD10CM:A59
has cross-reference: ICD9CM:131
has cross-reference: MESH:D014245
has cross-reference: NCI:C35720
has cross-reference: SNOMEDCT_US_2020_03_01:56335008
has cross-reference: UMLS_CUI:C0040921
has_obo_namespace: disease_ontology
has_related_synonym: trichomonas infection
id: DOID:1947
in subset: NCIthesaurus

cholecystitis
type: Class
subclass of: DOID 9446
textual definition: A cholangitis that is characterized by an inflammation that is located in the gallbladder.
imported from: doid.owl
has_alternative_id: DOID:1948
has_alternative_id: DOID:2829
has_alternative_id: DOID:9438
has cross-reference: GARD:30
has cross-reference: ICD10CM:K81
has cross-reference: ICD9CM:575.10
has cross-reference: MESH:D002764
has cross-reference: NCI:C34465
has cross-reference: OMIM:600803
has cross-reference: SNOMEDCT_US_2020_03_01:76581006
has cross-reference: UMLS_CUI:C0008325
alternative_term: acute and chronic cholecystitis
alternative_term: acute cholecystitis
alternative_term: acute on chronic cholecystitis
alternative_term: chronic cholecystitis
has_obo_namespace: disease_ontology
id: DOID:1949
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

fallopian tube disease
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is located_in the fallopian tube.
imported from: doid.owl
has cross-reference: MESH:D005184
has cross-reference: NCI:C26771
has cross-reference: SNOMEDCT_US_2020_03_01:128134005
has cross-reference: UMLS_CUI:C0015556
has_obo_namespace: disease_ontology
id: DOID:1962
in subset: NCIthesaurus

fallopian tube carcinoma
type: Class
subclass of: fallopian tube cancer
subclass of: carcinoma
textual definition: A fallopian tube cancer that is located_in the fallopian tube.
imported from: doid.owl
has cross-reference: MESH:D005185
has cross-reference: NCI:C3867
has cross-reference: SNOMEDCT_US_2020_03_01:276870001
has cross-reference: UMLS_CUI:C0238122
alternative_term: cancer of the fallopian tube
alternative_term: carcinoma of fallopian tube
alternative_term: fallopian tube Ca
has_obo_namespace: disease_ontology
id: DOID:1963
in subset: NCIthesaurus

fallopian tube cancer
type: Class
subclass of: female reproductive organ cancer
subclass of: fallopian tube disease
textual definition: A female reproductive organ cancer that is located_in fallopian tube.
imported from: doid.owl
has_alternative_id: DOID:1961
has cross-reference: GARD:9162
has cross-reference: ICD10CM:C57.0
has cross-reference: ICD9CM:183.2
has cross-reference: MESH:D005185
has cross-reference: NCI:C3032
has cross-reference: NCI:C7480
has cross-reference: SNOMEDCT_US_2020_03_01:126916003
has cross-reference: SNOMEDCT_US_2020_03_01:93794008
has cross-reference: UMLS_CUI:C0015558
has cross-reference: UMLS_CUI:C0153579
alternative_term: fallopian tube neoplasm
alternative_term: malignant neoplasm of uterine tube
alternative_term: malignant tumor of fallopian tube
alternative_term: malignant tumour of fallopian tube
alternative_term: neoplasm of fallopian tube
alternative_term: tumor of the fallopian tube
alternative_term: tumor, fallopian tube, malignant
has_obo_namespace: disease_ontology
id: DOID:1964
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

leiomyosarcoma
type: Class
subclass of: smooth muscle cancer
textual definition: A smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.
imported from: doid.owl
has cross-reference: GARD:6880
has cross-reference: MESH:D007890
has cross-reference: NCI:C3158
has cross-reference: SNOMEDCT_US_2020_03_01:443719001
has cross-reference: UMLS_CUI:C0023269
alternative_term: Leiomyosarcomas
has_obo_namespace: disease_ontology
id: DOID:1967
in subset: DO cancer slim
in subset: NCIthesaurus

cerebral palsy
type: Class
subclass of: DOID 936
textual definition: A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.
imported from: doid.owl
has_alternative_id: DOID:1968
has cross-reference: ICD10CM:G80
has cross-reference: MESH:D002547
has cross-reference: NCI:C34460
has cross-reference: SNOMEDCT_US_2020_03_01:155024003
has cross-reference: UMLS_CUI:C0007789
alternative_term: infantile cerebral palsy
has_obo_namespace: disease_ontology
id: DOID:1969
in subset: DO FlyBase slim
in subset: NCIthesaurus

adenosarcoma
type: Class
subclass of: carcinosarcoma
textual definition: A carcinosarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium.
imported from: doid.owl
has cross-reference: MESH:D018195
has cross-reference: NCI:C9474
has cross-reference: SNOMEDCT_US_2020_03_01:189804002
has cross-reference: UMLS_CUI:C0001442
alternative_term: Adenosarcoma
alternative_term: mullerian Adenosarcoma
has_obo_namespace: disease_ontology
id: DOID:1974
in subset: NCIthesaurus

rectal benign neoplasm
type: Class
subclass of: intestinal benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D012004
has cross-reference: NCI:C3350
has cross-reference: SNOMEDCT_US_2020_03_01:126847008
has cross-reference: UMLS_CUI:C0034885
alternative_term: Rectal tumor
alternative_term: neoplasm of rectum
alternative_term: rectum neoplasm
has_obo_namespace: disease_ontology
id: DOID:1984
in subset: NCIthesaurus

rectum cancer
type: Class
subclass of: DOID 9256
textual definition: A colorectal cancer that is located_in the rectum.
imported from: doid.owl
has_alternative_id: DOID:1989
has cross-reference: ICD10CM:C20
has cross-reference: ICD9CM:154.1
has cross-reference: MESH:D012004
has cross-reference: NCI:C7418
has cross-reference: NCI:C9382
has cross-reference: SNOMEDCT_US_2020_03_01:254582000
has cross-reference: SNOMEDCT_US_2020_03_01:93984006
has cross-reference: UMLS_CUI:C0007113
has cross-reference: UMLS_CUI:C0949022
alternative_term: carcinoma of rectum
alternative_term: carcinoma of the rectum
alternative_term: malignant Rectal tumor
alternative_term: malignant neoplasm of rectum
alternative_term: malignant rectum tumor
alternative_term: malignant tumor of rectum
alternative_term: rectal cancer
has_obo_namespace: disease_ontology
has_related_synonym: cancer of rectum
id: DOID:1993
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

rectum adenocarcinoma
type: Class
subclass of: rectum cancer
subclass of: adenocarcinoma
textual definition: A rectum cancer that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C9383
has cross-reference: SNOMEDCT_US_2020_03_01:254582000
has cross-reference: UMLS_CUI:C0149978
alternative_term: Rectal adenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:1996
in subset: DO cancer slim
in subset: NCIthesaurus

benign giant cell tumor
type: Class
subclass of: bone benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D005870
has cross-reference: NCI:C3055
has cross-reference: SNOMEDCT_US_2020_03_01:443790001
has cross-reference: UMLS_CUI:C0017525
has_obo_namespace: disease_ontology
id: DOID:200
in subset: NCIthesaurus

neuroma
type: Class
subclass of: nervous system benign neoplasm
textual definition: A nervous system benign neoplasm that is characterized as a nerve tissue tumor.
imported from: doid.owl
has cross-reference: MESH:D009463
has cross-reference: NCI:C3275
has cross-reference: SNOMEDCT_US_2020_03_01:25169009
has cross-reference: UMLS_CUI:C0027858
has_obo_namespace: disease_ontology
id: DOID:2001
in subset: NCIthesaurus

preretinal fibrosis
type: Class
subclass of: degeneration of macula and posterior pole
imported from: doid.owl
has cross-reference: ICD9CM:362.56
has cross-reference: MESH:D019773
has cross-reference: SNOMEDCT_US_2020_03_01:193391002
has cross-reference: UMLS_CUI:C0339543
alternative_term: Macular puckering of retina
alternative_term: Macular retinal puckering
alternative_term: cellophane maculopathy
has_obo_namespace: disease_ontology
id: DOID:2006

degeneration of macula and posterior pole
type: Class
subclass of: macular degeneration
imported from: doid.owl
has cross-reference: ICD10CM:H35.3
has cross-reference: ICD9CM:362.5
has cross-reference: SNOMEDCT_US_2020_03_01:193384000
has cross-reference: UMLS_CUI:C0339436
alternative_term: degeneration of macula and posterior pole of retina
alternative_term: degeneration of macula or posterior pole
has_obo_namespace: disease_ontology
id: DOID:2007

connective tissue cancer
type: Class
subclass of: musculoskeletal system cancer
subclass of: connective tissue disease
textual definition: A musculoskeletal system cancer that is located_in connective tissue.
imported from: doid.owl
has cross-reference: MESH:D009372
has cross-reference: SNOMEDCT_US_2020_03_01:126598008
has cross-reference: UMLS_CUI:C0027656
alternative_term: Tumour of connective tissue
alternative_term: connective tissue neoplasm
alternative_term: neoplasm of connective tissues
has_obo_namespace: disease_ontology
id: DOID:201
in subset: TopNodes DOcancerslim

Nezelof syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: T cell deficiency
textual definition: A T cell deficiency that results from the disfunction or underdevelopment of the thymus.
imported from: doid.owl
has cross-reference: ICD10CM:D81.4
has cross-reference: ICD9CM:279.13
has cross-reference: OMIM:242700
has cross-reference: ORDO:83471
has cross-reference: SNOMEDCT_US_2020_03_01:55602000
has cross-reference: UMLS_CUI:C0152094
alternative_term: Nezelof's syndrome
alternative_term: T-cell immunodeficiency with thymic aplasia
alternative_term: TIDTA
alternative_term: thymic aplasia
alternative_term: thymic dysplasia with normal immunoglobulins
has_obo_namespace: disease_ontology
id: DOID:2012
comment: OMIM mapping confirmed by DO. [SN].

hyperinsulinism
type: Class
subclass of: pancreas disease
subclass of: glucose metabolism disease
imported from: doid.owl
has cross-reference: ICD10CM:E16.1
has cross-reference: MESH:D006946
has cross-reference: SNOMEDCT_US_2020_03_01:154694003
has cross-reference: UMLS_CUI:C0020459
alternative_term: hyperinsulinemia
has_obo_namespace: disease_ontology
id: DOID:2018

placenta cancer
type: Class
subclass of: uterine cancer
subclass of: placenta disease
textual definition: A female reproductive organ cancer that is located_in the placenta.
imported from: doid.owl
has_alternative_id: DOID:2023
has cross-reference: ICD10CM:C58
has cross-reference: ICD9CM:181
has cross-reference: NCI:C3555
has cross-reference: SNOMEDCT_US_2020_03_01:188187004
has cross-reference: UMLS_CUI:C0153572
alternative_term: Placental tumors
alternative_term: malignant Placental tumor
alternative_term: malignant neoplasm of placenta
alternative_term: neoplasm of placenta
alternative_term: placental cancer
alternative_term: primary malignant neoplasm of placenta
has_obo_namespace: disease_ontology
id: DOID:2021
in subset: NCIthesaurus

gestational choriocarcinoma
type: Class
subclass of: choriocarcinoma
textual definition: A choriocarcicoma that develops in the presence of a preceding gestational event.
imported from: doid.owl
has cross-reference: NCI:C4646
has cross-reference: SNOMEDCT_US_2020_03_01:1884006
has cross-reference: UMLS_CUI:C0349557
alternative_term: Gestational choriocarcinoma
alternative_term: Gestational chorionepithelioma
alternative_term: Molar pregnancy with choriocarcinoma
has_obo_namespace: disease_ontology
id: DOID:2025
in subset: NCIthesaurus

exostosis
type: Class
subclass of: hyperostosis
textual definition: A hyperostosis that involves formation of new bone on the surface of preexisting bone.
imported from: doid.owl
has cross-reference: ICD10CM:M27.8
has cross-reference: ICD9CM:726.91
has cross-reference: MESH:D005096
has cross-reference: NCI:C3029
has cross-reference: SNOMEDCT_US_2020_03_01:80400009
has cross-reference: UMLS_CUI:C1442903
alternative_term: bone spur
alternative_term: bony outgrowth
alternative_term: orbital exostosis
alternative_term: osteophyte
alternative_term: swimmer's exostosis
has_obo_namespace: disease_ontology
id: DOID:203
in subset: NCIthesaurus

anxiety disorder
type: Class
subclass of: cognitive disorder
textual definition: A cognitive disorder that involves an excessive, irrational dread of everyday situations.
imported from: doid.owl
has_alternative_id: DOID:12884
has cross-reference: ICD10CM:F41.9
has cross-reference: MESH:D001008
has cross-reference: NCI:C2878
has cross-reference: OMIM:607834
has cross-reference: SNOMEDCT_US_2020_03_01:65673007
has cross-reference: UMLS_CUI:C0003469
alternative_term: anxiety
alternative_term: anxiety state
has_obo_namespace: disease_ontology
id: DOID:2030
in subset: NCIthesaurus

communication disorder
type: Class
subclass of: specific developmental disorder
textual definition: A specific developmental disorder that involves specific developmental disorders of speech and language.
imported from: doid.owl
has cross-reference: ICD10CM:F80.9
has cross-reference: MESH:D003147
has cross-reference: NCI:C2958
has cross-reference: SNOMEDCT_US_2020_03_01:74825008
has cross-reference: UMLS_CUI:C0009460
has_obo_namespace: disease_ontology
id: DOID:2033
in subset: NCIthesaurus

encephalomalacia
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by cerebral softening located_in cerebrum has_material_basis_in injured or dead cells of the central nervous system.
imported from: doid.owl
has cross-reference: MESH:D004678
has cross-reference: NCI:C98920
has cross-reference: SNOMEDCT_US_2020_03_01:58762006
has cross-reference: UMLS_CUI:C0014068
has_obo_namespace: disease_ontology
id: DOID:2034
in subset: NCIthesaurus

enthesopathy
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease characterized by damage of tissues located_in the entheses, the site of insertion of tendons or ligaments into bones or joint capsules, with symptoms of pain, swelling and inflammation.
imported from: doid.owl
has cross-reference: ICD10CM:M77.9
has cross-reference: ICD9CM:726.90
has cross-reference: MESH:D000070676
has cross-reference: SNOMEDCT_US_2020_03_01:278525009
has cross-reference: UMLS_CUI:C0242490
has_obo_namespace: disease_ontology
id: DOID:204

hepatitis B
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.
imported from: doid.owl
has_alternative_id: DOID:12591
has_alternative_id: DOID:12592
has_alternative_id: DOID:2042
has cross-reference: EFO:0004197
has cross-reference: MESH:D006509
has cross-reference: NCI:C3097
has cross-reference: SNOMEDCT_US_2020_03_01:66071002
has cross-reference: UMLS_CUI:C0019163
alternative_term: chronic hepatitis B
alternative_term: hepatitis B infection
has_obo_namespace: disease_ontology
has_related_synonym: Serum hepatitis
id: DOID:2043
in subset: NCIthesaurus
in subset: sexually transmitted infectious disease

hepatitis D
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.
imported from: doid.owl
has_alternative_id: DOID:2046
has cross-reference: MESH:D003699
has cross-reference: SNOMEDCT_US_2020_03_01:424460009
has cross-reference: UMLS_CUI:C0011226
alternative_term: delta hepatitis
has_obo_namespace: disease_ontology
id: DOID:2047

autoimmune hepatitis
type: Class
subclass of: autoimmune disease of gastrointestinal tract
textual definition: An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells.
imported from: doid.owl
has_alternative_id: DOID:4745
has cross-reference: GARD:5871
has cross-reference: ICD9CM:571.42
has cross-reference: MESH:D019693
has cross-reference: NCI:C27778
has cross-reference: SNOMEDCT_US_2020_03_01:16098491000119109
has cross-reference: UMLS_CUI:C0241910
has cross-reference: UMLS_CUI:C1332355
alternative_term: Autoimmune Hepatitis
alternative_term: Autoimmune chronic active hepatitis
alternative_term: Autoimmune hepatitis
alternative_term: autoimmune hepatitis with centrilobular necrosis
has_obo_namespace: disease_ontology
id: DOID:2048
in subset: NCIthesaurus

hyperostosis
type: Class
subclass of: bone remodeling disease
textual definition: A bone remodeling disease that results in an abnormal growth of located in bone.
imported from: doid.owl
has cross-reference: ICD10CM:M89.3
has cross-reference: MESH:D015576
has cross-reference: NCI:C34712
has cross-reference: SNOMEDCT_US_2020_03_01:13814009
has cross-reference: UMLS_CUI:C0020492
alternative_term: bone hypertrophy
alternative_term: hypertrophy of bone
has_obo_namespace: disease_ontology
id: DOID:205
in subset: NCIthesaurus

acute maxillary sinusitis
type: Class
subclass of: maxillary sinusitis
textual definition: A maxillary sinusitis which lasts for less than 4 weeks.
imported from: doid.owl
has cross-reference: ICD10CM:J01.0
has cross-reference: ICD9CM:461.0
has cross-reference: SNOMEDCT_US_2020_03_01:155499007
has cross-reference: UMLS_CUI:C0155804
alternative_term: acute antritis
has_obo_namespace: disease_ontology
id: DOID:2050

maxillary sinusitis
type: Class
subclass of: sinusitis
textual definition: A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.
imported from: doid.owl
has cross-reference: ICD10CM:J32.0
has cross-reference: MESH:D015523
has cross-reference: NCI:C34809
has cross-reference: SNOMEDCT_US_2020_03_01:275484005
has cross-reference: UMLS_CUI:C0024959
has_obo_namespace: disease_ontology
id: DOID:2051
in subset: NCIthesaurus

post-traumatic stress disorder
type: Class
subclass of: anxiety disorder
textual definition: An anxiety disorder which results from a traumatic experience that results in psychological trauma.
imported from: doid.owl
has cross-reference: ICD10CM:F43.1
has cross-reference: ICD9CM:309.81
has cross-reference: MESH:D013313
has cross-reference: NCI:C3389
has cross-reference: SNOMEDCT_US_2020_03_01:192415000
has cross-reference: UMLS_CUI:C0038436
alternative_term: PTSD
alternative_term: traumatic neurosis
has_obo_namespace: disease_ontology
has_related_synonym: post-traumatic stress disorder
id: DOID:2055
in subset: NCIthesaurus

chronic mucocutaneous candidiasis
type: Class
subclass of: candidiasis
subclass of: skin disease
subclass of: nail disease
textual definition: A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.
imported from: doid.owl
has_alternative_id: DOID:2056
has cross-reference: GARD:12313
has cross-reference: MESH:D002178
has cross-reference: NCI:C34444
has cross-reference: OMIM:114580
has cross-reference: OMIM:212050
has cross-reference: OMIM:607644
has cross-reference: OMIM:613108
has cross-reference: OMIM:613956
has cross-reference: OMIM:614162
has cross-reference: OMIM:615527
has cross-reference: OMIM:616445
has cross-reference: ORDO:1334
has cross-reference: SNOMEDCT_US_2020_03_01:234568006
has cross-reference: UMLS_CUI:C0006845
alternative_term: chronic Mucocutaneous Candidiasis
has_obo_namespace: disease_ontology
id: DOID:2058
in subset: DO rare slim
in subset: NCIthesaurus

vulvar disease
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is located_in the vulva.
imported from: doid.owl
has cross-reference: MESH:D014845
has cross-reference: NCI:C27631
has cross-reference: SNOMEDCT_US_2020_03_01:5089007
has cross-reference: UMLS_CUI:C0042994
has_obo_namespace: disease_ontology
id: DOID:2059
in subset: NCIthesaurus

nodular hidradenoma
type: Class
subclass of: hidradenoma
imported from: doid.owl
has_obo_namespace: disease_ontology
has_related_synonym: Eccrine nodular hidradenoma
has_related_synonym: nodular hidradenoma
id: DOID:2061

syringoma
type: Class
subclass of: sweat gland benign neoplasm
imported from: doid.owl
has cross-reference: GARD:10547
has cross-reference: MESH:D018252
has cross-reference: NCI:C3761
has cross-reference: OMIM:186600
has cross-reference: SNOMEDCT_US_2020_03_01:189051001
has cross-reference: UMLS_CUI:C0206673
has_obo_namespace: disease_ontology
id: DOID:2065
in subset: NCIthesaurus

intestinal perforation
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: ICD9CM:569.83
has cross-reference: MESH:D007416
has cross-reference: NCI:C39611
has cross-reference: SNOMEDCT_US_2020_03_01:56905009
has cross-reference: UMLS_CUI:C0021845
alternative_term: Perforation of intestine
has_obo_namespace: disease_ontology
id: DOID:2074
in subset: NCIthesaurus

constipation
type: Class
subclass of: DOID 9779
textual definition: A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces.
imported from: doid.owl
has cross-reference: ICD10CM:K59.0
has cross-reference: ICD9CM:564.0
has cross-reference: MESH:D003248
has cross-reference: NCI:C37930
has cross-reference: SNOMEDCT_US_2020_03_01:363693003
has cross-reference: UMLS_CUI:C0009806
has_obo_namespace: disease_ontology
id: DOID:2089
in subset: NCIthesaurus

transient arthritis
type: Class
subclass of: arthropathy
imported from: doid.owl
has cross-reference: ICD10CM:M12.8
has cross-reference: ICD9CM:716.4
has cross-reference: NCI:C35761
has cross-reference: SNOMEDCT_US_2020_03_01:66191007
has cross-reference: UMLS_CUI:C0152083
has_obo_namespace: disease_ontology
id: DOID:2092
in subset: NCIthesaurus

vulvar melanoma
type: Class
subclass of: vulva cancer
textual definition: A vulva cancer that has_material_basis in melanocytes.
imported from: doid.owl
has cross-reference: NCI:C40329
has cross-reference: SNOMEDCT_US_2020_03_01:254896002
has cross-reference: UMLS_CUI:C0241989
alternative_term: malignant melanoma of vulva
has_obo_namespace: disease_ontology
id: DOID:2093
in subset: NCIthesaurus

sweat gland cancer
type: Class
subclass of: sweat gland disease
subclass of: skin cancer
imported from: doid.owl
has cross-reference: ICD10CM:C44
has cross-reference: NCI:C4810
has cross-reference: SNOMEDCT_US_2020_03_01:255095005
has cross-reference: UMLS_CUI:C1321904
alternative_term: malignant neoplasm of sweat gland
alternative_term: malignant tumor of the Sweat gland
has_obo_namespace: disease_ontology
id: DOID:2095
in subset: NCIthesaurus

vulval Paget's disease
type: Class
subclass of: vulva adenocarcinoma
textual definition: A vulva adenocarcinoma that is characterized by distinctive large cells with prominent cytoplasm, referred to as Paget cells and is an intraepithelial neoplasm of epithelial origin expressing apocrine or eccrine glandular-like features.
imported from: doid.owl
has cross-reference: NCI:C4027
has cross-reference: SNOMEDCT_US_2020_03_01:254898001
has cross-reference: UMLS_CUI:C1275217
alternative_term: Paget's disease of vulva
alternative_term: Vulval Paget's disease
alternative_term: Vulvar Paget's disease
alternative_term: vulval Paget disease
has_obo_namespace: disease_ontology
id: DOID:2097
in subset: NCIthesaurus

vulva adenocarcinoma
type: Class
subclass of: vulva carcinoma
subclass of: adenocarcinoma
textual definition: A vulva carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C6380
has cross-reference: UMLS_CUI:C1336975
alternative_term: adenocarcinoma of Vulva
has_obo_namespace: disease_ontology
has_related_synonym: adenocarcinoma of the vulva
id: DOID:2098
in subset: NCIthesaurus

myotonia congenita
type: Class
subclass of: muscle tissue disease
textual definition: A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres.
imported from: doid.owl
has cross-reference: GARD:12301
has cross-reference: ICD9CM:359.22
has cross-reference: MESH:D009224
has cross-reference: NCI:C84912
has cross-reference: OMIM:160800
has cross-reference: OMIM:255700
has cross-reference: ORDO:614
has cross-reference: UMLS_CUI:C0027127
alternative_term: Congenital myotonia, autosomal dominant form
alternative_term: Thomsen disease
alternative_term: Thomsen's disease
has_obo_namespace: disease_ontology
id: DOID:2106
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cystoisosporiasis
type: Class
subclass of: coccidiosis
textual definition: A coccidiosis that involves infection of the epithelial cells of the small intestine with Cystoisospora belli, which results in nonbloody diarrhea with crampy abdominal pain, malabsorption and weight loss.
imported from: doid.owl
has_alternative_id: DOID:4891
has cross-reference: ICD10CM:A07.3
has cross-reference: MESH:D021865
has cross-reference: NCI:C4076
has cross-reference: SNOMEDCT_US_2020_03_01:73034009
has cross-reference: UMLS_CUI:C0311386
alternative_term: Infection by Isospora belli and Isospora hominis
alternative_term: Isosporosis
alternative_term: isosporiasis
has_obo_namespace: disease_ontology
id: DOID:2112
in subset: NCIthesaurus

coccidiosis
type: Class
subclass of: parasitic protozoa infectious disease
textual definition: A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection.
imported from: doid.owl
has cross-reference: MESH:D003048
has cross-reference: NCI:C34493
has cross-reference: SNOMEDCT_US_2020_03_01:186125004
has cross-reference: UMLS_CUI:C0009187
alternative_term: Coccidiosis
has_obo_namespace: disease_ontology
has_related_synonym: intestinal coccidiosis
id: DOID:2113
in subset: NCIthesaurus

B cell deficiency
type: Class
subclass of: primary immunodeficiency disease
textual definition: A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly.
imported from: doid.owl
has_alternative_id: DOID:6026
has cross-reference: ICD9CM:279.03
has cross-reference: SNOMEDCT_US_2020_03_01:190982008
has cross-reference: UMLS_CUI:C0154276
alternative_term: B cell (antibody) deficiencies
alternative_term: Immunoglobulin heavy chain deficiency
alternative_term: immunoglobulin heavy chain deletion
has_obo_namespace: disease_ontology
id: DOID:2115

focal dermal hypoplasia
type: Class
subclass of: X-linked dominant disease
subclass of: syndrome
textual definition: A syndrome characterized at birth by streaks of very thin skin (dermal hypoplasia), cutis aplasia, and telangiectases, and has_material_basis_in heterozygous mutation in the PORCN gene on chromosome Xp11.23.
imported from: doid.owl
has cross-reference: GARD:6457
has cross-reference: MESH:D005489
has cross-reference: NCI:C84715
has cross-reference: OMIM:305600
has cross-reference: ORDO:2092
has cross-reference: SNOMEDCT_US_2020_03_01:205573006
has cross-reference: UMLS_CUI:C0016395
alternative_term: FDH
alternative_term: FODH
alternative_term: Goltz syndrome
alternative_term: Goltz-Gorlin syndrome
has_obo_namespace: disease_ontology
id: DOID:2120
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

ectodermal dysplasia
type: Class
subclass of: syndrome
textual definition: A syndrome characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings.
imported from: doid.owl
has cross-reference: GARD:6317
has cross-reference: ICD9CM:757.31
has cross-reference: MESH:D004476
has cross-reference: NCI:C84683
has cross-reference: OMIM:PS305100
has cross-reference: ORDO:79373
has cross-reference: SNOMEDCT_US_2020_03_01:8654005
has cross-reference: UMLS_CUI:C0013575
alternative_term: Congenital ectodermal defect
alternative_term: Congenital ectodermal dysplasia
has_obo_namespace: disease_ontology
id: DOID:2121

tularemia
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues.
imported from: doid.owl
has cross-reference: GARD:396
has cross-reference: ICD9CM:021.8
has cross-reference: SNOMEDCT_US_2020_03_01:186298002
has cross-reference: UMLS_CUI:C0029835
has_obo_namespace: disease_ontology
id: DOID:2123
in subset: gram-negative bacterial infectious disease
in subset: tick-borne infectious disease
in subset: zoonotic infectious disease

atypical teratoid rhabdoid tumor
type: Class
subclass of: brain cancer
textual definition: A brain cancer that is usually located in the brain, but can occur anywhere in the central nervous system.
imported from: doid.owl
has cross-reference: NCI:C6906
has cross-reference: OMIM:609322
has cross-reference: ORDO:99966
has cross-reference: SNOMEDCT_US_2020_03_01:128792003
has cross-reference: UMLS_CUI:C1266184
alternative_term: Atypical teratoid/rhabdoid tumor
alternative_term: Atypical teratoid/rhabdoid tumour
alternative_term: Rhabdoid tumor of the CNS
alternative_term: Rhabdoid tumour of the CNS
alternative_term: atypical teratoid rhabdoid tumour
has_obo_namespace: disease_ontology
has_related_synonym: AT/RT
has_related_synonym: rhabdoid tumor predisposition syndrome
id: DOID:2129
in subset: DO FlyBase slim
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

teeth hard tissue disease
type: Class
subclass of: tooth disease
imported from: doid.owl
has cross-reference: ICD10CM:K03.8
has cross-reference: ICD9CM:521.8
has cross-reference: SNOMEDCT_US_2020_03_01:197505001
has cross-reference: UMLS_CUI:C0029770
has_obo_namespace: disease_ontology
id: DOID:214

urogenital tuberculosis
type: Class
subclass of: extrapulmonary tuberculosis
textual definition: An extrapulmonary tuberculosis that is located_in urogenital system.
imported from: doid.owl
has cross-reference: ICD10CM:A18.1
has cross-reference: ICD9CM:016
has cross-reference: MESH:D014401
has cross-reference: SNOMEDCT_US_2020_03_01:4445009
has cross-reference: UMLS_CUI:C0041333
has_obo_namespace: disease_ontology
has_related_synonym: Genitourinary tuberculosis
id: DOID:2149
in subset: gram-positive bacterial infectious disease

malignant ovarian surface epithelial-stromal neoplasm
type: Class
subclass of: ovary epithelial cancer
textual definition: An ovary epithelial cancer that has_material_basis_in epithelial and stromal tissue and arises from the surface epithelium of the ovary.
imported from: doid.owl
has cross-reference: NCI:C40026
has cross-reference: UMLS_CUI:C1518236
has_obo_namespace: disease_ontology
id: DOID:2151
in subset: NCIthesaurus

ovary epithelial cancer
type: Class
subclass of: ovarian cancer
subclass of: carcinoma
textual definition: An ovarian cancer that is derives_from ovarian surface epithelium.
imported from: doid.owl
has cross-reference: NCI:C4381
has cross-reference: SNOMEDCT_US_2020_03_01:237057005
has cross-reference: UMLS_CUI:C0341823
alternative_term: Ovarian Surface epithelial-Stromal tumor
has_obo_namespace: disease_ontology
id: DOID:2152
in subset: NCIthesaurus

nephroblastoma
type: Class
subclass of: kidney cancer
textual definition: A kidney cancer that affects the kidneys and typically located_in children.
imported from: doid.owl
has_alternative_id: DOID:5177
has_alternative_id: DOID:5180
has cross-reference: ICDO:M8960/3
has cross-reference: MESH:D009396
has cross-reference: NCI:C27730
has cross-reference: NCI:C3267
has cross-reference: NCI:C6180
has cross-reference: OMIM:194070
has cross-reference: SNOMEDCT_US_2020_03_01:25081006
has cross-reference: UMLS_CUI:C0027708
has cross-reference: UMLS_CUI:C1332219
has cross-reference: UMLS_CUI:C1333015
alternative_term: adult nephroblastoma
has_obo_namespace: disease_ontology
has_related_synonym: Wilms' tumor
id: DOID:2154
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

ovarian germ cell cancer
type: Class
subclass of: ovarian cancer
textual definition: An ovarian cancer that originates in the germ (egg) cells of the ovary.
imported from: doid.owl
has cross-reference: GARD:9330
has cross-reference: NCI:C3873
has cross-reference: OMIM:603737
has cross-reference: SNOMEDCT_US_2020_03_01:237059008
has cross-reference: UMLS_CUI:C0238324
alternative_term: germ cell neoplasm of Ovary
alternative_term: germ cell tumor of ovary
has_obo_namespace: disease_ontology
has_related_synonym: ovarian germ cell tumor
id: DOID:2156
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

dental caries
type: Class
subclass of: teeth hard tissue disease
textual definition: A teeth hard tissue disease that is characterized by damage to a tooth that can happen when decay-causing bacteria in your mouth make acids that attack the tooth’s surface, or enamel.
imported from: doid.owl
has_alternative_id: DOID:10785
has_alternative_id: DOID:10870
has_alternative_id: DOID:11913
has cross-reference: EFO:0003819
has cross-reference: ICD10CM:K02
has cross-reference: ICD10CM:K02.6
has cross-reference: ICD9CM:521.0
has cross-reference: ICD9CM:521.07
has cross-reference: MESH:D003731
has cross-reference: NCI:C52593
has cross-reference: SNOMEDCT_US_2020_03_01:155632007
has cross-reference: UMLS_CUI:C0011334
has cross-reference: UMLS_CUI:C1456145
alternative_term: Dental caries extending into pulp
alternative_term: Dental caries of smooth surface
alternative_term: Dental caries pit and fissure
has_obo_namespace: disease_ontology
id: DOID:216
in subset: NCIthesaurus

nasal cavity disease
type: Class
subclass of: nose disease
imported from: doid.owl
has_alternative_id: DOID:4728
has cross-reference: NCI:C27102
has cross-reference: SNOMEDCT_US_2020_03_01:232340005
has cross-reference: UMLS_CUI:C0339820
has_obo_namespace: disease_ontology
id: DOID:2163
in subset: NCIthesaurus

enamel caries
type: Class
subclass of: dental caries
imported from: doid.owl
has cross-reference: ICD9CM:521.01
has cross-reference: SNOMEDCT_US_2020_03_01:80353004
has cross-reference: UMLS_CUI:C0266853
alternative_term: Dental caries limited to enamel
alternative_term: primary dental caries
alternative_term: simple dental cavity
has_obo_namespace: disease_ontology
id: DOID:217

vaginitis
type: Class
subclass of: vaginal disease
textual definition: A vaginal disease that is characterized by inflammation of the vagina.
imported from: doid.owl
has_alternative_id: DOID:10769
has cross-reference: ICD9CM:616.1
has cross-reference: MESH:D014627
has cross-reference: NCI:C26911
has cross-reference: SNOMEDCT_US_2020_03_01:198212006
has cross-reference: SNOMEDCT_US_2020_03_01:393596009
has cross-reference: UMLS_CUI:C0042267
has cross-reference: UMLS_CUI:C0042268
has_obo_namespace: disease_ontology
id: DOID:2170
in subset: NCIthesaurus

ocular cancer
type: Class
subclass of: sensory system cancer
subclass of: eye disease
textual definition: A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye.
imported from: doid.owl
has_alternative_id: DOID:9985
has cross-reference: ICD9CM:190.8
has cross-reference: MESH:D005134
has cross-reference: NCI:C3030
has cross-reference: SNOMEDCT_US_2020_03_01:126995000
has cross-reference: SNOMEDCT_US_2020_03_01:188277006
has cross-reference: UMLS_CUI:C0015414
has cross-reference: UMLS_CUI:C0153632
alternative_term: Ocular tumor
alternative_term: eye neoplasm
alternative_term: malignant eye neoplasm
alternative_term: neoplasm of eye
alternative_term: neoplasm of eye proper
has_obo_namespace: disease_ontology
id: DOID:2174
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

ascending colon cancer
type: Class
subclass of: colon cancer
imported from: doid.owl
has cross-reference: ICD10CM:C18.2
has cross-reference: ICD9CM:153.6
has cross-reference: SNOMEDCT_US_2020_03_01:93683002
has cross-reference: UMLS_CUI:C0153439
alternative_term: Ca ascending colon
alternative_term: malignant neoplasm of right colon
alternative_term: malignant tumor of ascending colon
has_obo_namespace: disease_ontology
id: DOID:218

amelogenesis imperfecta
type: Class
subclass of: dental enamel hypoplasia
textual definition: A dental enamel hypoplasia characterized by abnormal enamel formation.
imported from: doid.owl
has cross-reference: GARD:5791
has cross-reference: ICD10CM:K00.5
has cross-reference: MESH:D000567
has cross-reference: OMIM:PS104500
has cross-reference: ORDO:88661
has cross-reference: SNOMEDCT_US_2020_03_01:78494001
has cross-reference: UMLS_CUI:C0002452
has_obo_namespace: disease_ontology
id: DOID:2187
in subset: DO rare slim
comment: Xref MGI.

colon cancer
type: Class
subclass of: colonic disease
subclass of: DOID 9256
textual definition: A colorectal cancer that is located_in the colon.
imported from: doid.owl
has cross-reference: ICD10CM:C18
has cross-reference: ICD9CM:153
has cross-reference: MESH:D003110
has cross-reference: NCI:C9242
has cross-reference: SNOMEDCT_US_2020_03_01:363406005
has cross-reference: UMLS_CUI:C0007102
has_obo_namespace: disease_ontology
id: DOID:219
in subset: DO cancer slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

factor XIII deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by easy bleeding, has_symptom prolonged umbilical cord bleeding, epistaxis, bleeding of the gums, menorrhagia, recurrent miscarriages, abnormal scar formation and wound healing, and hemarthrosis, and has_material_basis_in autosomal recessive inheritance of mutation of the F13A1 or F13B gene, which encodes Factor XIII, formally known as fibrin stabilizing factor.
imported from: doid.owl
has cross-reference: GARD:10766
has cross-reference: MESH:D005177
has cross-reference: NCI:C98941
has cross-reference: OMIM:613225
has cross-reference: OMIM:613235
has cross-reference: SNOMEDCT_US_2020_03_01:50189006
has cross-reference: UMLS_CUI:C0015530
alternative_term: Factor XIII deficiency disease
alternative_term: Hereditary factor XIII deficiency disease
alternative_term: deficiency, Laki-Lorand factor
has_obo_namespace: disease_ontology
id: DOID:2211
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hemorrhagic disease
type: Class
subclass of: blood coagulation disease
imported from: doid.owl
has cross-reference: ICD10CM:D69.9
has cross-reference: ICD9CM:287.9
has cross-reference: MESH:D006474
has cross-reference: SNOMEDCT_US_2020_03_01:268884000
has cross-reference: UMLS_CUI:C0019087
alternative_term: Hemorrhagic diathesis
alternative_term: Hemorrhagic disease
has_obo_namespace: disease_ontology
id: DOID:2213

factor VII deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by easy bleeding, has_symptom epistaxis, bleeding of the gums, menorrhagia, and occasionally hemarthrosis, and has_material_basis_in autosomal recessive inheritance of mutation in the F7 gene, which encodes coagulation factor VII, an important factor in the clotting cascade.
imported from: doid.owl
has cross-reference: GARD:2238
has cross-reference: ICD10CM:D68.2
has cross-reference: MESH:D005168
has cross-reference: NCI:C131631
has cross-reference: SNOMEDCT_US_2020_03_01:154820003
has cross-reference: UMLS_CUI:C0015503
alternative_term: Factor VII deficiency
alternative_term: deficiency, stable
has_obo_namespace: disease_ontology
id: DOID:2215
in subset: NCIthesaurus

factor V deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: blood coagulation disease
imported from: doid.owl
has cross-reference: GARD:2237
has cross-reference: ICD10CM:D68.2
has cross-reference: MESH:D005166
has cross-reference: NCI:C98938
has cross-reference: OMIM:227400
has cross-reference: SNOMEDCT_US_2020_03_01:191284007
has cross-reference: UMLS_CUI:C0015499
alternative_term: Hereditary hypoproaccelerinaemia
alternative_term: Labile factor deficiency
alternative_term: Proaccelerin deficiency
alternative_term: deficiency, labile
has_obo_namespace: disease_ontology
id: DOID:2216
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Bernard-Soulier syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease characterized by autosomal recessive inheritance of mucosal bleeding, purpuric skin bleeding, epistaxis, and menorrhagia with prolonged bleeding times, enlarged platelets and absence of platelet aggregation in response to von Willebrand factor that has material_basis_in mutation in the GP1BA gene, the GP1BB gene, or the GP9 gene which are subunits of the platelet membrane von Willebrand factor receptor complex, glycoprotein Ib.
imported from: doid.owl
has cross-reference: MESH:D001606
has cross-reference: NCI:C84595
has cross-reference: OMIM:231200
has cross-reference: ORDO:274
has cross-reference: SNOMEDCT_US_2020_03_01:54569005
has cross-reference: UMLS_CUI:C0005129
alternative_term: Bernard - Soulier thrombopathy
alternative_term: Bernard Soulier syndrome
alternative_term: Giant platelet syndrome
alternative_term: Hemorrhagic dystrophic thrombocytopenia
alternative_term: Thrombopathy, Bernard-Soulier
has_obo_namespace: disease_ontology
id: DOID:2217
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

blood platelet disease
type: Class
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by an abnormal increase or decrease in platelets or platelet dysfunction.
imported from: doid.owl
has cross-reference: MESH:D001791
has cross-reference: NCI:C131634
has cross-reference: SNOMEDCT_US_2020_03_01:22716005
has cross-reference: UMLS_CUI:C0005818
alternative_term: Thrombocytopathy
alternative_term: platelet disorder
has_obo_namespace: disease_ontology
id: DOID:2218

Glanzmann's thrombasthenia
type: Class
subclass of: blood platelet disease
textual definition: A blood coagulation disease characterized by autosomal recessive inheritance of failure of platelet aggregation and absent or diminished clot retraction that has material_basis_in mutation in the ITGA2B or ITGB3 genes on chromosome 17q21.32.
imported from: doid.owl
has cross-reference: GARD:2478
has cross-reference: ICD10CM:D69.1
has cross-reference: MESH:D013915
has cross-reference: NCI:C61249
has cross-reference: OMIM:273800
has cross-reference: ORDO:849
has cross-reference: SNOMEDCT_US_2020_03_01:32942005
has cross-reference: UMLS_CUI:C0040015
alternative_term: BDPLT2
alternative_term: Glanzmann thrombasthenia
alternative_term: Glycoprotein IIb/IIIa defect
alternative_term: Thrombocytasthenia
alternative_term: deficiency of GP IIb-IIIa complex
alternative_term: deficiency of glycoprotein complex IIb-IIIa
alternative_term: deficiency of platelet fibrinogen receptor
alternative_term: platelet glycoprotein IIb-IIIa deficiency
alternative_term: platelet-type bleeding disorder 2
alternative_term: thrombasthenia of Glanzmann and Naegeli
has_obo_namespace: disease_ontology
id: DOID:2219
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

factor X deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by the partial or complete absence of factor X activity in the blood.
imported from: doid.owl
has cross-reference: GARD:6404
has cross-reference: MESH:D005171
has cross-reference: NCI:C131632
has cross-reference: SNOMEDCT_US_2020_03_01:76642003
has cross-reference: UMLS_CUI:C0015519
alternative_term: Factor X deficiency
alternative_term: disease, Stuart-Prower
has_obo_namespace: disease_ontology
id: DOID:2222
in subset: NCIthesaurus

platelet storage pool deficiency
type: Class
subclass of: blood platelet disease
imported from: doid.owl
has cross-reference: GARD:5034
has cross-reference: MESH:D010981
has cross-reference: OMIM:185050
has cross-reference: SNOMEDCT_US_2020_03_01:234474009
has cross-reference: UMLS_CUI:C0032197
alternative_term: Dense body defect
alternative_term: Platelet dense granule deficiency
alternative_term: Platelet storage pool defect
has_obo_namespace: disease_ontology
id: DOID:2223

essential thrombocythemia
type: Class
subclass of: myeloproliferative neoplasm
textual definition: A myeloproliferative neoplasm that is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage and that results_in the overproduction of platelets.
imported from: doid.owl
has cross-reference: GARD:6594
has cross-reference: ICD10CM:D47.3
has cross-reference: ICD9CM:238.71
has cross-reference: MESH:D013920
has cross-reference: NCI:C3407
has cross-reference: OMIM:187950
has cross-reference: OMIM:601977
has cross-reference: OMIM:614521
has cross-reference: ORDO:3318
has cross-reference: ORDO:71493
has cross-reference: SNOMEDCT_US_2020_03_01:234499005
has cross-reference: UMLS_CUI:C0040028
alternative_term: Essential thrombocythaemia
alternative_term: familial thrombocytosis
alternative_term: hemorrhagic thrombocythemia
alternative_term: hereditary thrombocythemia
alternative_term: primary Thrombocytosis
has_obo_namespace: disease_ontology
id: DOID:2224
in subset: DO cancer slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

myeloproliferative neoplasm
type: Class
subclass of: myeloid neoplasm
textual definition: A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.
imported from: doid.owl
has_alternative_id: DOID:6002
has cross-reference: ICD10CM:D47.1
has cross-reference: NCI:C4345
has cross-reference: SNOMEDCT_US_2020_03_01:115248004
has cross-reference: UMLS_CUI:C1292778
alternative_term: CMPD
alternative_term: CMPD, U
alternative_term: chronic myeloproliferative disease
has_obo_namespace: disease_ontology
id: DOID:2226
in subset: NCIthesaurus

thrombocytosis
type: Class
subclass of: blood platelet disease
textual definition: A blood platelet disease that is characterized by the presence of high platelet counts in the blood.
imported from: doid.owl
has cross-reference: MESH:D013922
has cross-reference: NCI:C35530
has cross-reference: SNOMEDCT_US_2020_03_01:165557006
has cross-reference: UMLS_CUI:C0836924
alternative_term: Thrombocythaemia
has_obo_namespace: disease_ontology
id: DOID:2228
in subset: NCIthesaurus

factor XI deficiency
type: Class
subclass of: autosomal genetic disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by deficiency of factor XI clotting factor and mild prolonged bleeding, especially of mucosal sites following trauma, and has_material_basis_in homozygous, compound heterozygous, or heterozygous mutation of the coagulation factor XI gene of chromosome 4q35.2.
imported from: doid.owl
has cross-reference: GARD:9670
has cross-reference: ICD10CM:D68.1
has cross-reference: ICD9CM:286.2
has cross-reference: MESH:D005173
has cross-reference: NCI:C84705
has cross-reference: OMIM:612416
has cross-reference: SNOMEDCT_US_2020_03_01:49762007
has cross-reference: UMLS_CUI:C0015523
alternative_term: Congenital factor XI deficiency
alternative_term: Hereditary factor XI deficiency disease
alternative_term: Rosenthal's disease
alternative_term: hemophilia C
alternative_term: plasma thromboplastin antecedent deficiency
has_obo_namespace: disease_ontology
id: DOID:2229
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

factor XII deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by prolonged PTT time without clinical symptoms, and has_material_basis_in a mutation in the F12 gene on chromosome 5q33.
imported from: doid.owl
has cross-reference: GARD:6558
has cross-reference: MESH:D005175
has cross-reference: NCI:C131740
has cross-reference: OMIM:234000
has cross-reference: ORDO:330
has cross-reference: SNOMEDCT_US_2020_03_01:46981006
has cross-reference: UMLS_CUI:C0015526
alternative_term: Factor XII deficiency disease
alternative_term: Hageman Factor deficiency
alternative_term: deficiency, Hageman
has_obo_namespace: disease_ontology
id: DOID:2231
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

focal epilepsy
type: Class
subclass of: epilepsy
textual definition: An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response.
imported from: doid.owl
has cross-reference: MESH:D004828
has cross-reference: NCI:C122812
has cross-reference: SNOMEDCT_US_2020_03_01:230381009
has cross-reference: UMLS_CUI:C0014547
alternative_term: localisation-related epilepsy
alternative_term: partial epilepsy
has_obo_namespace: disease_ontology
id: DOID:2234
in subset: NCIthesaurus

congenital afibrinogenemia
type: Class
subclass of: autosomal recessive disease
subclass of: physical disorder
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by an impaired blood clotting resulting from a lack deficiency of a the fibrinogen protein (coagulation factor I).
imported from: doid.owl
has cross-reference: GARD:5761
has cross-reference: MESH:D000347
has cross-reference: NCI:C98130
has cross-reference: OMIM:202400
has cross-reference: SNOMEDCT_US_2020_03_01:278504009
has cross-reference: UMLS_CUI:C0001733
alternative_term: Factor I deficiency
alternative_term: Fibrinogen deficiency
has_obo_namespace: disease_ontology
id: DOID:2236
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hepatitis
type: Class
subclass of: liver disease
imported from: doid.owl
has_alternative_id: DOID:12352
has_alternative_id: DOID:14551
has_alternative_id: DOID:1706
has_alternative_id: DOID:1707
has_alternative_id: DOID:2238
has cross-reference: ICD10CM:K73.9
has cross-reference: ICD9CM:570
has cross-reference: ICD9CM:571.4
has cross-reference: ICD9CM:571.41
has cross-reference: MESH:D006521
has cross-reference: NCI:C82978
has cross-reference: SNOMEDCT_US_2020_03_01:155813004
has cross-reference: SNOMEDCT_US_2020_03_01:197268000
has cross-reference: SNOMEDCT_US_2020_03_01:266539002
has cross-reference: UMLS_CUI:C0001308
has cross-reference: UMLS_CUI:C0019189
has cross-reference: UMLS_CUI:C0149519
alternative_term: acute and subacute liver necrosis
alternative_term: acute hepatitis
alternative_term: acute/subac. necrosis of liver
alternative_term: animal hepatitis
alternative_term: chronic hepatitis
alternative_term: chronic persistent hepatitis
has_obo_namespace: disease_ontology
id: DOID:2237
in subset: NCIthesaurus

transient cerebral ischemia
type: Class
subclass of: brain ischemia
textual definition: A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.
imported from: doid.owl
has_alternative_id: DOID:2315
has cross-reference: ICD10CM:G45.9
has cross-reference: MESH:D002546
has cross-reference: NCI:C50781
has cross-reference: SNOMEDCT_US_2020_03_01:195196001
has cross-reference: UMLS_CUI:C0007787
alternative_term: TIA
alternative_term: TIA - Transient ischaemic attack
alternative_term: TRANSIENT ISCHEMIC ATTACK
alternative_term: Transient cerebral ischaemia
alternative_term: Transient cerebral ischemia
alternative_term: Transient ischemic attacks
alternative_term: transient ischemic attack
has_obo_namespace: disease_ontology
id: DOID:224
in subset: NCIthesaurus

spondylosis
type: Class
subclass of: bone structure disease
textual definition: An bone structure disease that involves degeneration between vertebra located_in vertebral column.
imported from: doid.owl
has_alternative_id: DOID:8708
has_alternative_id: DOID:8709
has_alternative_id: DOID:8888
has_alternative_id: DOID:8905
has_alternative_id: DOID:9949
has cross-reference: ICD10CM:M47
has cross-reference: ICD9CM:721.9
has cross-reference: MESH:D055009
has cross-reference: OMIM:184300
has cross-reference: SNOMEDCT_US_2020_03_01:8847002
has cross-reference: UMLS_CUI:C0038019
alternative_term: Lumbar spondylosis with myelopathy
alternative_term: Spondylogenic compression of lumbar spinal cord
alternative_term: Spondylogenic compression of thoracic spinal cord
alternative_term: Spondylosis with myelopathy
alternative_term: Thoracic or lumbar spondylosis with myelopathy
alternative_term: lumbosacral spondylosis without myelopathy
alternative_term: spondylosis with myelopathy
has_obo_namespace: disease_ontology
id: DOID:2247

syndrome
type: Class
subclass of: disease
textual definition: A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality.
imported from: doid.owl
has cross-reference: MESH:D013577
has cross-reference: NCI:C28193
has cross-reference: SNOMEDCT_US_2020_03_01:64572001
has cross-reference: UMLS_CUI:C0039082
has_obo_namespace: disease_ontology
id: DOID:225
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

cervix disease
type: Class
subclass of: uterine disease
textual definition: A uterine disease that is located_in the cervix.
imported from: doid.owl
has cross-reference: MESH:D002577
has cross-reference: NCI:C40241
has cross-reference: SNOMEDCT_US_2020_03_01:63339007
has cross-reference: UMLS_CUI:C0007867
has_obo_namespace: disease_ontology
id: DOID:2253
in subset: NCIthesaurus

osteochondrodysplasia
type: Class
subclass of: bone development disease
textual definition: A bone development disease that results_in defective development of cartilage or bone.
imported from: doid.owl
has_alternative_id: DOID:1764
has cross-reference: ICD10CM:Q78.9
has cross-reference: ICD9CM:756.4
has cross-reference: MESH:D010009
has cross-reference: NCI:C34466
has cross-reference: NCI:C84978
has cross-reference: SNOMEDCT_US_2020_03_01:205510001
has cross-reference: SNOMEDCT_US_2020_03_01:67988000
has cross-reference: UMLS_CUI:C0008449
has cross-reference: UMLS_CUI:C0029422
alternative_term: Cartilage Development disorder
alternative_term: Congenital anomaly of cartilage
alternative_term: Osteochondrodysplasia syndrome
alternative_term: chondrodystrophy
alternative_term: skeletal dysplasia
has_obo_namespace: disease_ontology
id: DOID:2256
in subset: NCIthesaurus

ankylosis
type: Class
subclass of: arthropathy
textual definition: Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.
imported from: doid.owl
has cross-reference: ICD10CM:M24.6
has cross-reference: ICD9CM:718.5
has cross-reference: MESH:D000844
has cross-reference: SNOMEDCT_US_2020_03_01:36504009
has cross-reference: UMLS_CUI:C0003090
has_obo_namespace: disease_ontology
id: DOID:227

vulvovaginal candidiasis
type: Class
subclass of: vaginal disease
subclass of: candidiasis
textual definition: A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.
imported from: doid.owl
has cross-reference: ICD10CM:B37.3
has cross-reference: ICD9CM:112.1
has cross-reference: MESH:D002181
has cross-reference: NCI:C2914
has cross-reference: SNOMEDCT_US_2020_03_01:154404004
has cross-reference: UMLS_CUI:C0700345
alternative_term: Candidal vulvovaginitis
alternative_term: Candidal: cervix
alternative_term: Candidiasis of vulva and vagina
alternative_term: Monilial vulvovaginitis
alternative_term: Vulvovaginal Candidiasis
has_obo_namespace: disease_ontology
id: DOID:2272
in subset: NCIthesaurus

pharyngitis
type: Class
subclass of: DOID 974
textual definition: An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as sore throat. The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.
imported from: doid.owl
has_alternative_id: DOID:10455
has_alternative_id: DOID:11586
has_alternative_id: DOID:11588
has_alternative_id: DOID:938
has_alternative_id: DOID:939
has cross-reference: ICD10CM:J02
has cross-reference: ICD9CM:462
has cross-reference: ICD9CM:472
has cross-reference: ICD9CM:478.20
has cross-reference: MESH:D010608
has cross-reference: MESH:D010612
has cross-reference: NCI:C26850
has cross-reference: NCI:C26851
has cross-reference: NCI:C34355
has cross-reference: SNOMEDCT_US_2020_03_01:195654001
has cross-reference: SNOMEDCT_US_2020_03_01:195763009
has cross-reference: SNOMEDCT_US_2020_03_01:37616004
has cross-reference: SNOMEDCT_US_2020_03_01:75860007
has cross-reference: UMLS_CUI:C0001344
has cross-reference: UMLS_CUI:C0031345
has cross-reference: UMLS_CUI:C0031350
has cross-reference: UMLS_CUI:C0155824
alternative_term: Inflamed throat
alternative_term: Persistent sore throat
alternative_term: Pharyngeal disorder
alternative_term: Pharyngitis - acute
alternative_term: Sore throat - chronic
alternative_term: acute pharyngitis
alternative_term: acute sore throat
alternative_term: chronic pharyn/nasopharyngitis
alternative_term: chronic pharyngitis
alternative_term: chronic pharyngitis and nasopharyngitis
alternative_term: chronic sore throat
has_obo_namespace: disease_ontology
has_related_synonym: pharyngeal disease
id: DOID:2275
in subset: NCIthesaurus

gonadal disease
type: Class
subclass of: endocrine system disease
textual definition: An endocrine system disease that is located_in the gonads.
imported from: doid.owl
has cross-reference: MESH:D006058
has cross-reference: NCI:C26786
has cross-reference: UMLS_CUI:C0018050
has_obo_namespace: disease_ontology
id: DOID:2277
in subset: NCIthesaurus

hidradenitis suppurativa
type: Class
subclass of: hidradenitis
textual definition: A hidradenitis that is characterized by chronic inflammation of the apocrine sweat glands, has_symptom painful nodules, abscesses, sinus tract formation, scarring, erythema, pruritis, and pain, and has_material_basis_in chronic inflammation of the apocrine sweat glands leading to recurrent folliculitis and an accompanying immune response that worsens inflammation.
imported from: doid.owl
has cross-reference: GARD:6658
has cross-reference: ICD10CM:L73.2
has cross-reference: MESH:D017497
has cross-reference: NCI:C128429
has cross-reference: OMIM:142690
has cross-reference: OMIM:613736
has cross-reference: OMIM:613737
has cross-reference: SNOMEDCT_US_2020_03_01:201204008
has cross-reference: UMLS_CUI:C0162836
alternative_term: Acne inversa, familial
alternative_term: Hidradenitis suppurativa
has_obo_namespace: disease_ontology
id: DOID:2280
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hidradenitis
type: Class
subclass of: sweat gland disease
textual definition: A sweat gland disease that is characterized by inflammation of the apocrine sweat glands and has_symptom erythema, edema, papules, plaques, pruritis, and pain.
imported from: doid.owl
has cross-reference: ICD9CM:705.83
has cross-reference: MESH:D016575
has cross-reference: NCI:C112190
has cross-reference: SNOMEDCT_US_2020_03_01:267866004
has cross-reference: UMLS_CUI:C0085160
alternative_term: Hidradenitis
alternative_term: Hydradenitis
has_obo_namespace: disease_ontology
id: DOID:2282
in subset: NCIthesaurus

keratopathy
type: Class
subclass of: corneal disease
imported from: doid.owl
has cross-reference: NCI:C27012
has cross-reference: UMLS_CUI:C0235270
has_obo_namespace: disease_ontology
id: DOID:2283
in subset: NCIthesaurus

female reproductive system disease
type: Class
subclass of: reproductive system disease
textual definition: A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.
imported from: doid.owl
has cross-reference: ICD9CM:629.9
has cross-reference: MESH:D005831
has cross-reference: SNOMEDCT_US_2020_03_01:38233001
has cross-reference: UMLS_CUI:C0017411
has_obo_namespace: disease_ontology
id: DOID:229

leptospirosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.
imported from: doid.owl
has_alternative_id: DOID:11348
has cross-reference: GARD:7881
has cross-reference: ICD10CM:A27
has cross-reference: ICD10CM:A27.0
has cross-reference: ICD9CM:100
has cross-reference: ICD9CM:100.0
has cross-reference: MESH:D007922
has cross-reference: MESH:D014895
has cross-reference: NCI:C84825
has cross-reference: SNOMEDCT_US_2020_03_01:154391003
has cross-reference: SNOMEDCT_US_2020_03_01:398067003
has cross-reference: UMLS_CUI:C0023364
has cross-reference: UMLS_CUI:C0043102
alternative_term: Fort Bragg fever
alternative_term: Leptospirosis icterohaemorrhagica
alternative_term: Rat Catcher's Yellows
alternative_term: Weil's disease
alternative_term: nanukayami fever
alternative_term: spirochetal jaundice
has_obo_namespace: disease_ontology
id: DOID:2297
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

lateral sclerosis
type: Class
subclass of: motor neuron disease
textual definition: A motor neuron disease characterized by painless but progressive weakness and stiffness of the muscles of the legs.
imported from: doid.owl
has cross-reference: ICD10CM:G12.23
has cross-reference: ICD9CM:335.24
has cross-reference: MESH:D016472
has cross-reference: NCI:C129933
has cross-reference: OMIM:611637
has cross-reference: ORDO:35689
has cross-reference: SNOMEDCT_US_2020_03_01:81211007
has cross-reference: UMLS_CUI:C0154682
alternative_term: adult-onset primary lateral sclerosis
alternative_term: primary lateral sclerosis
has_obo_namespace: disease_ontology
id: DOID:230
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

spondylolysis
type: Class
subclass of: bone structure disease
textual definition: A bone structure disease that involves a defect located_in lumbar vertebral column.
imported from: doid.owl
has cross-reference: ICD10CM:M43.0
has cross-reference: MESH:D013169
has cross-reference: NCI:C35034
has cross-reference: SNOMEDCT_US_2020_03_01:203688008
has cross-reference: UMLS_CUI:C0038018
has_obo_namespace: disease_ontology
id: DOID:2300
in subset: NCIthesaurus

stereotypic movement disorder
type: Class
subclass of: specific developmental disorder
textual definition: A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking.
imported from: doid.owl
has cross-reference: ICD10CM:F98.4
has cross-reference: ICD9CM:307.3
has cross-reference: MESH:D019956
has cross-reference: SNOMEDCT_US_2020_03_01:5507002
has cross-reference: UMLS_CUI:C0038273
alternative_term: Stereotyped repetitive movements
alternative_term: Stereotypy habit disorder
has_obo_namespace: disease_ontology
id: DOID:2303

motor neuron disease
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease that is located_in the motor neurones.
imported from: doid.owl
has cross-reference: ICD10CM:G12.2
has cross-reference: ICD9CM:335.2
has cross-reference: MESH:D016472
has cross-reference: SNOMEDCT_US_2020_03_01:37340000
has cross-reference: UMLS_CUI:C0085084
has_obo_namespace: disease_ontology
id: DOID:231
in subset: DO FlyBase slim

nocardiosis
type: Class
subclass of: opportunistic bacterial infectious disease
textual definition: An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.
imported from: doid.owl
has cross-reference: GARD:7210
has cross-reference: ICD10CM:A43
has cross-reference: MESH:D009617
has cross-reference: SNOMEDCT_US_2020_03_01:29227009
has cross-reference: UMLS_CUI:C0028242
alternative_term: Nocardia infectious disease
has_obo_namespace: disease_ontology
id: DOID:2312
in subset: gram-positive bacterial infectious disease

brain ischemia
type: Class
subclass of: ischemia
subclass of: cerebrovascular disease
textual definition: An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.
imported from: doid.owl
has cross-reference: MESH:D002545
has cross-reference: SNOMEDCT_US_2020_03_01:193049009
has cross-reference: UMLS_CUI:C0007786
alternative_term: Ischaemic encephalopathy
alternative_term: Ischemic encephalopathy
alternative_term: cerebral ischemia
has_obo_namespace: disease_ontology
id: DOID:2316

obstructive lung disease
type: Class
subclass of: lung disease
textual definition: A lung disease that is characterized by narrowing of pulmonary airways.
imported from: doid.owl
has cross-reference: MESH:D008173
has cross-reference: UMLS_CUI:C0600260
alternative_term: respiratory airway obstruction
has_obo_namespace: disease_ontology
id: DOID:2320

gastroenteritis
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.
imported from: doid.owl
has_alternative_id: DOID:4094
has_alternative_id: DOID:5269
has cross-reference: ICD10CM:K52.9
has cross-reference: MESH:D005759
has cross-reference: NCI:C34632
has cross-reference: SNOMEDCT_US_2020_03_01:154278002
has cross-reference: UMLS_CUI:C0017160
alternative_term: cholera morbus
alternative_term: infectious colitis, enteritis and gastroenteritis
has_obo_namespace: disease_ontology
id: DOID:2326
in subset: NCIthesaurus

mandibular cancer
type: Class
subclass of: jaw cancer
textual definition: A jaw cancer and mandibular disease that affects your lower jawbone.
imported from: doid.owl
has_alternative_id: DOID:12408
has cross-reference: ICD10CM:C41.1
has cross-reference: ICD9CM:170.1
has cross-reference: MESH:D008339
has cross-reference: NCI:C35178
has cross-reference: SNOMEDCT_US_2020_03_01:126551000
has cross-reference: SNOMEDCT_US_2020_03_01:448668007
has cross-reference: UMLS_CUI:C0024694
has cross-reference: UMLS_CUI:C0153511
alternative_term: malignant neoplasm of inferior maxilla
alternative_term: malignant neoplasm of lower Jaw bone
alternative_term: mandible cancer
alternative_term: neoplasm of mandible
has_obo_namespace: disease_ontology
has_related_synonym: malignant neoplasm of mandible
has_related_synonym: mandibular neoplasm
id: DOID:2338
in subset: NCIthesaurus

craniosynostosis
type: Class
subclass of: synostosis
textual definition: A synostosis that results_in premature fusion located_in skull.
imported from: doid.owl
has cross-reference: GARD:6209
has cross-reference: ICD10CM:Q75.0
has cross-reference: MESH:D003398
has cross-reference: NCI:C84655
has cross-reference: OMIM:123100
has cross-reference: OMIM:182212
has cross-reference: OMIM:600593
has cross-reference: OMIM:600775
has cross-reference: OMIM:604757
has cross-reference: OMIM:615314
has cross-reference: ORDO:1531
has cross-reference: SNOMEDCT_US_2020_03_01:205414007
has cross-reference: UMLS_CUI:C0010278
alternative_term: Premature closure of cranial sutures
has_obo_namespace: disease_ontology
id: DOID:2340
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS].

polyclonal hypergammaglobulinemia
type: Class
subclass of: plasma protein metabolism disease
imported from: doid.owl
has cross-reference: ICD10CM:D89.0
has cross-reference: ICD9CM:273.0
has cross-reference: NCI:C35885
has cross-reference: SNOMEDCT_US_2020_03_01:190808009
has cross-reference: UMLS_CUI:C0154254
alternative_term: Polyclonal hypergammaglobulinemia
has_obo_namespace: disease_ontology
id: DOID:2344
in subset: NCIthesaurus

plasma protein metabolism disease
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder that involves plasma protein metabolism malfunction.
imported from: doid.owl
has cross-reference: ICD9CM:273.8
has cross-reference: SNOMEDCT_US_2020_03_01:190822009
has cross-reference: UMLS_CUI:C0029594
has_obo_namespace: disease_ontology
id: DOID:2345

arteriosclerotic cardiovascular disease
type: Class
subclass of: arteriosclerosis
imported from: doid.owl
has cross-reference: ICD10CM:I70
has cross-reference: ICD9CM:440
has cross-reference: MESH:D050197
has cross-reference: NCI:C34403
has cross-reference: NCI:C35768
has cross-reference: SNOMEDCT_US_2020_03_01:155414001
has cross-reference: SNOMEDCT_US_2020_03_01:39468009
has cross-reference: UMLS_CUI:C0004153
has cross-reference: UMLS_CUI:C3665365
alternative_term: Cardiovascular arteriosclerosis
has_obo_namespace: disease_ontology
id: DOID:2348
in subset: NCIthesaurus

arteriosclerosis
type: Class
subclass of: artery disease
textual definition: An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.
imported from: doid.owl
has cross-reference: ICD10CM:I70
has cross-reference: MESH:D001161
has cross-reference: NCI:C34398
has cross-reference: SNOMEDCT_US_2020_03_01:195251000
has cross-reference: UMLS_CUI:C0003850
alternative_term: Arteriosclerosis
alternative_term: Arteriosclerotic vascular disease
has_obo_namespace: disease_ontology
id: DOID:2349
in subset: NCIthesaurus

colonic benign neoplasm
type: Class
subclass of: lymphangioma
subclass of: intestinal benign neoplasm
subclass of: colonic disease
textual definition: An intestinal benign neoplasm that is located_in the colon.
imported from: doid.owl
has cross-reference: MESH:D003110
has cross-reference: NCI:C2953
has cross-reference: SNOMEDCT_US_2020_03_01:126838000
has cross-reference: UMLS_CUI:C0009375
alternative_term: Colonic Mass
alternative_term: Colonic tumor
alternative_term: colon neoplasm
alternative_term: neoplasm of colon
has_obo_namespace: disease_ontology
id: DOID:235
in subset: NCIthesaurus

iron metabolism disease
type: Class
subclass of: mineral metabolism disease
imported from: doid.owl
has cross-reference: ICD10CM:E83.1
has cross-reference: ICD9CM:275.0
has cross-reference: MESH:D019189
has cross-reference: SNOMEDCT_US_2020_03_01:30913008
has cross-reference: UMLS_CUI:C0012715
alternative_term: Iron disorder
alternative_term: disorder of iron metabolism
alternative_term: iron disorder
has_obo_namespace: disease_ontology
id: DOID:2351

hemochromatosis
type: Class
subclass of: DOID 896
textual definition: A metal metabolism disorder characterized by the accumulation of iron in various organs of the body.
imported from: doid.owl
has cross-reference: ICD10CM:E83.11
has cross-reference: MESH:D006432
has cross-reference: NCI:C84481
has cross-reference: OMIM:231100
has cross-reference: OMIM:PS235200
has cross-reference: ORDO:139498
has cross-reference: SNOMEDCT_US_2020_03_01:86781004
has cross-reference: UMLS_CUI:C0018995
alternative_term: Haemochromatosis
alternative_term: diabetes bronze
alternative_term: iron storage disorder
has_obo_namespace: disease_ontology
id: DOID:2352
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

myelophthisic anemia
type: Class
subclass of: aplastic anemia
textual definition: An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas.
imported from: doid.owl
has cross-reference: ICD10CM:D61.82
has cross-reference: MESH:D000750
has cross-reference: SNOMEDCT_US_2020_03_01:2694001
has cross-reference: UMLS_CUI:C0002890
alternative_term: ANEMIA LEUKOERYTHROBLASTIC
alternative_term: Anemia, leukoerythroblastic
alternative_term: Leukoerythroblastosis
has_obo_namespace: disease_ontology
has_related_synonym: myelophthisis
id: DOID:2354
in subset: NCIthesaurus

anemia
type: Class
subclass of: hematopoietic system disease
textual definition: A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.
imported from: doid.owl
has cross-reference: EFO:0004272
has cross-reference: ICD10CM:D64.9
has cross-reference: ICD9CM:285.9
has cross-reference: MESH:D000740
has cross-reference: NCI:C2869
has cross-reference: SNOMEDCT_US_2020_03_01:64593003
has cross-reference: UMLS_CUI:C0002871
alternative_term: anaemia
has_obo_namespace: disease_ontology
id: DOID:2355
in subset: NCIthesaurus
comment: PRISM.

macrocytic anemia
type: Class
subclass of: anemia
imported from: doid.owl
has cross-reference: MESH:D000748
has cross-reference: NCI:C34381
has cross-reference: SNOMEDCT_US_2020_03_01:83414005
has cross-reference: UMLS_CUI:C0002886
alternative_term: ANEMIA MACROCYTIC
alternative_term: Macrocytic anaemia
has_obo_namespace: disease_ontology
id: DOID:2361
in subset: NCIthesaurus

West Nile encephalitis
type: Class
subclass of: DOID 934
subclass of: DOID 936
textual definition: A viral infectious disease that results in inflammation located in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.
imported from: doid.owl
has cross-reference: GARD:9959
has cross-reference: ICD10CM:A92.31
has cross-reference: ICD9CM:066.41
has cross-reference: MESH:D014901
has cross-reference: SNOMEDCT_US_2020_03_01:392662004
has cross-reference: UMLS_CUI:C0751583
alternative_term: West Nile Fever with encephalitis
alternative_term: West Nile fever encephalitis
has_obo_namespace: disease_ontology
id: DOID:2365
in subset: zoonotic infectious disease

West Nile fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.
imported from: doid.owl
has cross-reference: ICD10CM:A92.3
has cross-reference: ICD9CM:066.4
has cross-reference: MESH:D014901
has cross-reference: SNOMEDCT_US_2020_03_01:12381007
has cross-reference: UMLS_CUI:C0043124
has_obo_namespace: disease_ontology
id: DOID:2366
in subset: zoonotic infectious disease

neuroaxonal dystrophy
type: Class
subclass of: cerebral degeneration
imported from: doid.owl
has cross-reference: MESH:D019150
has cross-reference: NCI:C161542
has cross-reference: SNOMEDCT_US_2020_03_01:230365004
has cross-reference: UMLS_CUI:C0338473
has_obo_namespace: disease_ontology
id: DOID:2367

gangliosidosis
type: Class
subclass of: autosomal recessive disease
subclass of: sphingolipidosis
textual definition: A sphingolipidosis that is characterized by the accumulation of lipids known as gangliosides.
imported from: doid.owl
has cross-reference: GARD:12510
has cross-reference: ICD10CM:E75.10
has cross-reference: MESH:D005733
has cross-reference: ORDO:309144
has cross-reference: SNOMEDCT_US_2020_03_01:50967008
has cross-reference: UMLS_CUI:C0017083
has_obo_namespace: disease_ontology
id: DOID:2368

hereditary elliptocytosis
type: Class
subclass of: hematopoietic system disease
textual definition: A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present.
imported from: doid.owl
has cross-reference: GARD:6621
has cross-reference: ICD10CM:D58.1
has cross-reference: ICD9CM:282.1
has cross-reference: MESH:D004612
has cross-reference: NCI:C35882
has cross-reference: OMIM:130600
has cross-reference: OMIM:611804
has cross-reference: ORDO:288
has cross-reference: SNOMEDCT_US_2020_03_01:154801000
has cross-reference: UMLS_CUI:C0013902
alternative_term: Congenital elliptocytosis
alternative_term: ovalocytosis
has_obo_namespace: disease_ontology
id: DOID:2373
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

multiple sclerosis
type: Class
subclass of: autoimmune disease of central nervous system
subclass of: demyelinating disease
textual definition: A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
imported from: doid.owl
has cross-reference: EFO:0003885
has cross-reference: GARD:10255
has cross-reference: ICD10CM:G35
has cross-reference: ICD9CM:340
has cross-reference: MESH:D009103
has cross-reference: NCI:C3243
has cross-reference: OMIM:612594
has cross-reference: OMIM:612595
has cross-reference: OMIM:612596
has cross-reference: SNOMEDCT_US_2020_03_01:155023009
has cross-reference: UMLS_CUI:C0026769
alternative_term: Generalized multiple sclerosis
alternative_term: insular sclerosis
has_obo_namespace: disease_ontology
id: DOID:2377
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

kernicterus
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction.
imported from: doid.owl
has cross-reference: GARD:6830
has cross-reference: ICD10CM:P57
has cross-reference: MESH:D007647
has cross-reference: NCI:C84799
has cross-reference: SNOMEDCT_US_2020_03_01:157135006
has cross-reference: UMLS_CUI:C0022610
alternative_term: bilirubin encephalopathy
has_obo_namespace: disease_ontology
id: DOID:2382
in subset: NCIthesaurus

neonatal jaundice
type: Class
subclass of: pigmentation disease
textual definition: A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.
imported from: doid.owl
has cross-reference: ICD10CM:P59.9
has cross-reference: MESH:D007567
has cross-reference: NCI:C99246
has cross-reference: SNOMEDCT_US_2020_03_01:299968002
has cross-reference: UMLS_CUI:C0022353
alternative_term: neonatal hyperbilirubinemia
alternative_term: neonatal icterus
has_obo_namespace: disease_ontology
id: DOID:2383
in subset: NCIthesaurus

Wernicke encephalopathy
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).
imported from: doid.owl
has cross-reference: ICD10CM:E51.2
has cross-reference: MESH:D014899
has cross-reference: SNOMEDCT_US_2020_03_01:190627001
has cross-reference: UMLS_CUI:C0043121
alternative_term: Wernicke's disease
alternative_term: Wernicke's encephalopathy
has_obo_namespace: disease_ontology
id: DOID:2384

renal artery disease
type: Class
subclass of: artery disease
imported from: doid.owl
has cross-reference: ICD9CM:593.81
has cross-reference: NCI:C35338
has cross-reference: SNOMEDCT_US_2020_03_01:16934004
has cross-reference: UMLS_CUI:C0268790
alternative_term: renal vascular disease
alternative_term: vascular disorder of kidney
has_obo_namespace: disease_ontology
id: DOID:2388
in subset: NCIthesaurus

ovarian cancer
type: Class
subclass of: ovarian disease
subclass of: female reproductive organ cancer
textual definition: A female reproductive organ cancer that is located_in the ovary.
imported from: doid.owl
has_alternative_id: DOID:0060070
has_alternative_id: DOID:2144
has_alternative_id: DOID:9595
has cross-reference: GARD:7295
has cross-reference: ICD10CM:C56
has cross-reference: ICD9CM:183.0
has cross-reference: MESH:D010051
has cross-reference: NCI:C4984
has cross-reference: NCI:C7431
has cross-reference: OMIM:167000
has cross-reference: OMIM:607893
has cross-reference: ORDO:213500
has cross-reference: ORDO:213517
has cross-reference: SNOMEDCT_US_2020_03_01:123843001
has cross-reference: SNOMEDCT_US_2020_03_01:372117006
has cross-reference: SNOMEDCT_US_2020_03_01:93934004
has cross-reference: UMLS_CUI:C0919267
has cross-reference: UMLS_CUI:C1140680
has cross-reference: UMLS_CUI:C1299247
alternative_term: malignant Ovarian tumor
alternative_term: malignant tumour of ovary
alternative_term: ovarian neoplasm
alternative_term: ovary neoplasm
alternative_term: primary ovarian cancer
alternative_term: tumor of the Ovary
has_obo_namespace: disease_ontology
id: DOID:2394
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

iris disease
type: Class
subclass of: uveal disease
imported from: doid.owl
has cross-reference: MESH:D007499
has cross-reference: NCI:C34737
has cross-reference: SNOMEDCT_US_2020_03_01:85478004
has cross-reference: UMLS_CUI:C0022078
has_obo_namespace: disease_ontology
id: DOID:240
in subset: NCIthesaurus

granular cell tumor
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: GARD:9618
has cross-reference: MESH:D016586
has cross-reference: NCI:C3474
has cross-reference: SNOMEDCT_US_2020_03_01:12169001
has cross-reference: UMLS_CUI:C0085167
alternative_term: neoplasm of granular cell
has_obo_namespace: disease_ontology
id: DOID:2411
in subset: NCIthesaurus

cutaneous ganglioneuroma
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4481
has cross-reference: SNOMEDCT_US_2020_03_01:254766004
has cross-reference: UMLS_CUI:C0346063
alternative_term: Cutaneous Ganglioneuroma
alternative_term: Ganglioneuroma of skin
has_obo_namespace: disease_ontology
id: DOID:2425
in subset: NCIthesaurus

gangliocytoma
type: Class
subclass of: central nervous system benign neoplasm
textual definition: A central nervous system benign neoplasm that has_material_basis_in mature neurons, and is classified by the absence of neoplastic glial cells.
imported from: doid.owl
has cross-reference: GARD:10638
has cross-reference: MESH:D005729
has cross-reference: NCI:C6934
has cross-reference: SNOMEDCT_US_2020_03_01:78268004
alternative_term: gangliocytoma of central nervous system
has_obo_namespace: disease_ontology
id: DOID:2426
in subset: NCIthesaurus

epidermal appendage tumor
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4463
has cross-reference: SNOMEDCT_US_2020_03_01:126489007
has cross-reference: UMLS_CUI:C0345988
alternative_term: neoplasm of skin with adnexal differentiation
alternative_term: neoplasm of the skin Appendage
alternative_term: skin appendage tumour
has_obo_namespace: disease_ontology
id: DOID:2433
in subset: NCIthesaurus

glomangioma
type: Class
subclass of: benign perivascular tumor
imported from: doid.owl
has cross-reference: MESH:D005918
has cross-reference: NCI:C4222
has cross-reference: SNOMEDCT_US_2020_03_01:7429002
has cross-reference: UMLS_CUI:C0334421
has_obo_namespace: disease_ontology
id: DOID:2436
in subset: NCIthesaurus

dermis tumor
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4475
has cross-reference: SNOMEDCT_US_2020_03_01:254735005
has cross-reference: UMLS_CUI:C0346041
alternative_term: dermis tumour
alternative_term: neoplasm of Dermis
alternative_term: tumor of dermis
alternative_term: tumour of dermis
has_obo_namespace: disease_ontology
id: DOID:2438
in subset: NCIthesaurus

hyperpituitarism
type: Class
subclass of: pituitary gland disease
imported from: doid.owl
has cross-reference: MESH:D006964
has cross-reference: SNOMEDCT_US_2020_03_01:10649000
has cross-reference: UMLS_CUI:C0020506
has_obo_namespace: disease_ontology
id: DOID:2444

acromegaly
type: Class
subclass of: hyperpituitarism
textual definition: A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.
imported from: doid.owl
has cross-reference: GARD:5725
has cross-reference: MESH:D000172
has cross-reference: NCI:C84533
has cross-reference: SNOMEDCT_US_2020_03_01:154698000
has cross-reference: UMLS_CUI:C0001206
has_obo_namespace: disease_ontology
id: DOID:2449
in subset: NCIthesaurus

central retinal vein occlusion
type: Class
subclass of: retinal vein occlusion
imported from: doid.owl
has cross-reference: ICD10CM:H34.81
has cross-reference: ICD9CM:362.35
has cross-reference: MESH:D012170
has cross-reference: NCI:C118859
has cross-reference: SNOMEDCT_US_2020_03_01:193378003
has cross-reference: UMLS_CUI:C0154841
has_obo_namespace: disease_ontology
id: DOID:2450
in subset: NCIthesaurus

protein S deficiency
type: Class
subclass of: thrombophilia
subclass of: blood protein disease
imported from: doid.owl
has cross-reference: GARD:4524
has cross-reference: ICD10CM:D68.59
has cross-reference: MESH:D018455
has cross-reference: NCI:C99026
has cross-reference: SNOMEDCT_US_2020_03_01:1563006
has cross-reference: UMLS_CUI:C0242666
alternative_term: Protein S deficiency
alternative_term: Protein S deficiency disease
has_obo_namespace: disease_ontology
id: DOID:2451
in subset: NCIthesaurus

thrombophilia
type: Class
subclass of: blood coagulation disease
textual definition: A blood coagulation disease that is characterized by an increased tendency to form clots.
imported from: doid.owl
has cross-reference: ICD10CM:D68.59
has cross-reference: MESH:D019851
has cross-reference: NCI:C84479
has cross-reference: OMIM:PS188050
has cross-reference: SNOMEDCT_US_2020_03_01:191302007
has cross-reference: UMLS_CUI:C0398623
alternative_term: hypercoagulability state
has_obo_namespace: disease_ontology
id: DOID:2452
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

retinal vascular disease
type: Class
subclass of: vascular disease
subclass of: retinal disease
imported from: doid.owl
has cross-reference: NCI:C35170
has cross-reference: SNOMEDCT_US_2020_03_01:57534004
has cross-reference: UMLS_CUI:C0154833
alternative_term: retina circulation disorder
has_obo_namespace: disease_ontology
id: DOID:2462
in subset: NCIthesaurus

psychotic disorder
type: Class
subclass of: cognitive disorder
textual definition: A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.
imported from: doid.owl
has cross-reference: EFO:0000677
has cross-reference: ICD9CM:298.8
has cross-reference: UMLS_CUI:C0029516
alternative_term: mental or behavioural disorder
has_obo_namespace: disease_ontology
id: DOID:2468

opportunistic mycosis
type: Class
subclass of: systemic mycosis
textual definition: A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.
imported from: doid.owl
has_alternative_id: DOID:0050137
has cross-reference: ICD9CM:118
has cross-reference: SNOMEDCT_US_2020_03_01:78999002
has cross-reference: UMLS_CUI:C0029119
alternative_term: Opportunistic mycoses
alternative_term: Opportunistic mycosis
alternative_term: opportunistic systemic mycoses
has_obo_namespace: disease_ontology
id: DOID:2473

chronic conjunctivitis
type: Class
subclass of: conjunctivitis
imported from: doid.owl
has cross-reference: ICD10CM:H10.4
has cross-reference: ICD9CM:372.1
has cross-reference: NCI:C35197
has cross-reference: SNOMEDCT_US_2020_03_01:155163007
has cross-reference: UMLS_CUI:C0155145
alternative_term: chronic Conjunctivitis
has_obo_namespace: disease_ontology
id: DOID:2475
in subset: NCIthesaurus

motor peripheral neuropathy
type: Class
subclass of: DOID 870
imported from: doid.owl
has cross-reference: ICD10CM:G60.0
has cross-reference: MESH:D015417
has cross-reference: NCI:C75467
has cross-reference: SNOMEDCT_US_2020_03_01:128202008
has cross-reference: UMLS_CUI:C0027888
alternative_term: HSMN
alternative_term: HSMN - Hereditary sensory and motor neuropathy
alternative_term: Hereditary motor and sensory neuropathy
alternative_term: neuropathic muscular atrophy
has_obo_namespace: disease_ontology
id: DOID:2477
in subset: NCIthesaurus

central nervous system origin vertigo
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by vertigo caused by hemorrhagic insult, ischemic insult or mass lesion of the cerebellum, the vestibular nuclei, and the brainstem, has_symptom dizziness, has_symptom nausea, has_symptom vomiting and has_symptom difficulty walking.
imported from: doid.owl
has cross-reference: ICD10CM:H81.4
has cross-reference: ICD9CM:386.2
has cross-reference: MESH:D014717
has cross-reference: SNOMEDCT_US_2020_03_01:20425006
has cross-reference: UMLS_CUI:C0155503
alternative_term: Vertigo of central origin
alternative_term: central vestibular vertigo
has_obo_namespace: disease_ontology
id: DOID:2479

trachea leiomyoma
type: Class
subclass of: respiratory system benign neoplasm
subclass of: leiomyoma
subclass of: tracheal disease
textual definition: A respiratory system benign neoplasm that derives_from smooth muscle cells and is located_in the trachea.
imported from: doid.owl
has_alternative_id: DOID:246
has cross-reference: MESH:D014134
has cross-reference: NCI:C3419
has cross-reference: NCI:C6049
has cross-reference: SNOMEDCT_US_2020_03_01:126703006
has cross-reference: UMLS_CUI:C0040582
has cross-reference: UMLS_CUI:C1336772
alternative_term: leiomyoma of the Trachea
has_obo_namespace: disease_ontology
id: DOID:248
in subset: NCIthesaurus

phosphorus metabolism disease
type: Class
subclass of: mineral metabolism disease
imported from: doid.owl
has cross-reference: ICD9CM:275.3
has cross-reference: MESH:D010760
has cross-reference: NCI:C97095
has cross-reference: SNOMEDCT_US_2020_03_01:190858002
has cross-reference: UMLS_CUI:C0031707
alternative_term: Phosphorus disorder
alternative_term: disorder of phosphorus metabolism
alternative_term: phosphorus metabolism disorder
has_obo_namespace: disease_ontology
id: DOID:2485
in subset: NCIthesaurus

congenital nervous system abnormality
type: Class
subclass of: physical disorder
subclass of: DOID 863
imported from: doid.owl
has cross-reference: ICD9CM:742
has cross-reference: SNOMEDCT_US_2020_03_01:204018008
has cross-reference: UMLS_CUI:C0158538
alternative_term: congenital neurologic anomaly
has_obo_namespace: disease_ontology
id: DOID:2490

sensory peripheral neuropathy
type: Class
subclass of: DOID 870
textual definition: A neuropathy that involves damage to nerves of the peripheral nervous system.
imported from: doid.owl
has_alternative_id: DOID:10596
has cross-reference: ICD9CM:356.2
has cross-reference: MESH:D009477
has cross-reference: NCI:C3501
has cross-reference: SNOMEDCT_US_2020_03_01:193163001
has cross-reference: SNOMEDCT_US_2020_03_01:95662005
has cross-reference: UMLS_CUI:C0151313
has cross-reference: UMLS_CUI:C0699739
alternative_term: Sensory neuropathy
alternative_term: peripheral Sensory Neuropathy
alternative_term: sensory neuropathy
has_obo_namespace: disease_ontology
id: DOID:2491
in subset: NCIthesaurus

gastric antral vascular ectasia
type: Class
subclass of: capillary disease
imported from: doid.owl
has cross-reference: MESH:D020252
has cross-reference: NCI:C84724
has cross-reference: SNOMEDCT_US_2020_03_01:412795008
has cross-reference: UMLS_CUI:C0267211
alternative_term: Watermelon stomach
has_obo_namespace: disease_ontology
id: DOID:2493
in subset: NCIthesaurus

angiodysplasia
type: Class
subclass of: vascular disease
textual definition: A vascular disease that is characterized as a small vascular malformation of the gut.
imported from: doid.owl
has_alternative_id: DOID:12071
has cross-reference: MESH:D016888
has cross-reference: SNOMEDCT_US_2020_03_01:71072006
has cross-reference: UMLS_CUI:C0085411
alternative_term: angiodysplasia of stomach and duodenum with hemorrhage
has_obo_namespace: disease_ontology
id: DOID:2494

senile angioma
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4390
has cross-reference: SNOMEDCT_US_2020_03_01:5050001
has cross-reference: UMLS_CUI:C0343082
alternative_term: Senile hemangioma
alternative_term: Senile naevus of skin
has_obo_namespace: disease_ontology
id: DOID:2495
in subset: NCIthesaurus

enamel erosion
type: Class
subclass of: tooth erosion
imported from: doid.owl
has cross-reference: ICD9CM:521.31
has cross-reference: UMLS_CUI:C1456161
has_obo_namespace: disease_ontology
id: DOID:2497

tooth erosion
type: Class
subclass of: teeth hard tissue disease
imported from: doid.owl
has_alternative_id: DOID:11509
has_alternative_id: DOID:12687
has cross-reference: ICD10CM:K03.2
has cross-reference: ICD9CM:521.3
has cross-reference: MESH:D014077
has cross-reference: SNOMEDCT_US_2020_03_01:82212003
has cross-reference: UMLS_CUI:C0040436
alternative_term: generalized erosion
alternative_term: localized erosion
has_obo_namespace: disease_ontology
id: DOID:2498

Takayasu's arteritis
type: Class
subclass of: artery disease
subclass of: DOID 865
textual definition: A vasculitis that involves inflammation of the aorta that carries blood from the heart to the rest of the body.
imported from: doid.owl
has_alternative_id: DOID:13377
has cross-reference: GARD:7730
has cross-reference: ICD10CM:M31.4
has cross-reference: ICD9CM:446.7
has cross-reference: MESH:D001015
has cross-reference: MESH:D013625
has cross-reference: NCI:C34391
has cross-reference: NCI:C35062
has cross-reference: OMIM:207600
has cross-reference: SNOMEDCT_US_2020_03_01:359789008
has cross-reference: SNOMEDCT_US_2020_03_01:42153001
has cross-reference: UMLS_CUI:C0003490
has cross-reference: UMLS_CUI:C0039263
alternative_term: Aortic Arch syndrome
alternative_term: Aortic arch arteritis
alternative_term: Aortic arch syndrome
alternative_term: Idiopathic aortitis
alternative_term: Takayasu arteritis
alternative_term: Takayasu's disease
has_obo_namespace: disease_ontology
id: DOID:2508
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

alcohol-induced mental disorder
type: Class
subclass of: DOID 8646
imported from: doid.owl
has cross-reference: ICD9CM:291.89
has cross-reference: UMLS_CUI:C1456283
has_obo_namespace: disease_ontology
id: DOID:251

nevoid basal cell carcinoma syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome characterized by multiple early-onset basal cell carcinoma, multiple jaw keratocysts and skeletal abnormalities that has_material_basis_in heterozygous mutation in either PTCH1, PTCH2, or SUFU on chromosome 9q22, 1p32, or 10q24-q25, respectively.
imported from: doid.owl
has cross-reference: GARD:7166
has cross-reference: MEDDRA:10062804
has cross-reference: MESH:D001478
has cross-reference: NCI:C2892
has cross-reference: OMIM:109400
has cross-reference: ORDO:377
has cross-reference: SNOMEDCT_US_2020_03_01:69408002
has cross-reference: UMLS_CUI:C0004779
alternative_term: Gorlin syndrome
alternative_term: NBCCS
alternative_term: basal cell nevus syndrome
has_obo_namespace: disease_ontology
id: DOID:2512
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

basal cell carcinoma
type: Class
subclass of: skin carcinoma
textual definition: A skin carcinoma affecting basal cells.
imported from: doid.owl
has_alternative_id: DOID:4275
has_alternative_id: DOID:4276
has cross-reference: EFO:0004193
has cross-reference: KEGG:05217
has cross-reference: MESH:D018295
has cross-reference: NCI:C156767
has cross-reference: NCI:C3784
has cross-reference: NCI:C7586
has cross-reference: SNOMEDCT_US_2020_03_01:127570002
has cross-reference: SNOMEDCT_US_2020_03_01:154507009
has cross-reference: SNOMEDCT_US_2020_03_01:252995000
has cross-reference: UMLS_CUI:C0007117
has cross-reference: UMLS_CUI:C0206710
has cross-reference: UMLS_CUI:C1368295
alternative_term: Basal cell cancer
alternative_term: Basal cell carcinoma of skin
alternative_term: Basal cell neoplasm
alternative_term: Basal cell tumor
alternative_term: Epithelioma basal cell
alternative_term: Rodent ulcer
alternative_term: malignant Basal cell neoplasm
alternative_term: malignant basal cell tumor
has_obo_namespace: disease_ontology
id: DOID:2513
in subset: NCIthesaurus
comment: Xref MGI.

orchitis
type: Class
subclass of: testicular disease
imported from: doid.owl
has cross-reference: ICD10CM:N45.2
has cross-reference: MESH:D009920
has cross-reference: NCI:C97145
has cross-reference: SNOMEDCT_US_2020_03_01:367112009
has cross-reference: UMLS_CUI:C0029191
alternative_term: Inflammation of testis
alternative_term: Orchititis
has_obo_namespace: disease_ontology
id: DOID:2518
in subset: NCIthesaurus

testicular disease
type: Class
subclass of: gonadal disease
subclass of: male reproductive system disease
imported from: doid.owl
has cross-reference: MESH:D013733
has cross-reference: NCI:C26890
has cross-reference: SNOMEDCT_US_2020_03_01:236763001
has cross-reference: UMLS_CUI:C0039584
alternative_term: disorder of testis
alternative_term: testis disorder
has_obo_namespace: disease_ontology
id: DOID:2519
in subset: NCIthesaurus

alcoholic psychosis
type: Class
subclass of: alcohol-induced mental disorder
textual definition: An alcohol-induced mental disorder involving prominent hallucinations and delusions occurring during or shortly after acute alcohol intoxication or withdrawal.
imported from: doid.owl
has cross-reference: ICD9CM:291.9
has cross-reference: MESH:D011604
has cross-reference: SNOMEDCT_US_2020_03_01:154852003
has cross-reference: UMLS_CUI:C0033936
alternative_term: Alcoholic psychoses
has_obo_namespace: disease_ontology
id: DOID:252

nephrosis
type: Class
subclass of: proteinuria
textual definition: A proteinuria that is characterized by the leaking of blood protein into the urine, swelling or edema, and degenerative lesions without inflammation.
imported from: doid.owl
has cross-reference: MESH:D009401
has cross-reference: SNOMEDCT_US_2020_03_01:90708001
has cross-reference: UMLS_CUI:C0027720
has_obo_namespace: disease_ontology
id: DOID:2527

splenic disease
type: Class
subclass of: lymphatic system disease
imported from: doid.owl
has_alternative_id: DOID:0000815
has cross-reference: ICD10CM:D73
has cross-reference: ICD9CM:289.50
has cross-reference: MESH:D013158
has cross-reference: NCI:C35823
has cross-reference: SNOMEDCT_US_2020_03_01:51244008
has cross-reference: UMLS_CUI:C0037997
alternative_term: Dyssplenism
alternative_term: Spleen disease
has_obo_namespace: disease_ontology
id: DOID:2529
in subset: NCIthesaurus

splenic abscess
type: Class
subclass of: splenic disease
imported from: doid.owl
has cross-reference: ICD10CM:D73.3
has cross-reference: NCI:C35347
has cross-reference: SNOMEDCT_US_2020_03_01:82053000
has cross-reference: UMLS_CUI:C0272412
has_obo_namespace: disease_ontology
id: DOID:2530
in subset: NCIthesaurus

hematologic cancer
type: Class
subclass of: organ system cancer
subclass of: hematopoietic system disease
textual definition: An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.
imported from: doid.owl
has_alternative_id: DOID:1034
has_alternative_id: DOID:2532
has cross-reference: MESH:D019337
has cross-reference: NCI:C27134
has cross-reference: SNOMEDCT_US_2020_03_01:414388001
has cross-reference: UMLS_CUI:C0376544
alternative_term: Hematologic malignancy
alternative_term: Hematologic neoplasm
alternative_term: Hematological tumors
alternative_term: blood cancer
alternative_term: hematopoietic and lymphoid system tumor
alternative_term: hematopoietic cancer
alternative_term: hematopoietic neoplasm
alternative_term: hematopoietic tumors
alternative_term: malignant hematopoietic neoplasm
has_obo_namespace: disease_ontology
id: DOID:2531
in subset: DO FlyBase slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

splenic infarction
type: Class
subclass of: splenic disease
imported from: doid.owl
has cross-reference: GARD:9973
has cross-reference: ICD10CM:D73.5
has cross-reference: MESH:D013159
has cross-reference: SNOMEDCT_US_2020_03_01:22996003
has cross-reference: UMLS_CUI:C0037998
alternative_term: Splenic infarct
alternative_term: Splenic infarction
has_obo_namespace: disease_ontology
id: DOID:2533

chronic inflammatory demyelinating polyneuritis
type: Class
subclass of: inflammatory and toxic neuropathy
imported from: doid.owl
has cross-reference: ICD10CM:G61.81
has cross-reference: ICD9CM:357.81
has cross-reference: MESH:D020277
has cross-reference: NCI:C84636
has cross-reference: SNOMEDCT_US_2020_03_01:128209004
has cross-reference: UMLS_CUI:C0393819
has_obo_namespace: disease_ontology
id: DOID:2536
in subset: NCIthesaurus

inflammatory and toxic neuropathy
type: Class
subclass of: DOID 870
imported from: doid.owl
has cross-reference: ICD9CM:357
has cross-reference: SNOMEDCT_US_2020_03_01:193172009
has cross-reference: UMLS_CUI:C0154758
has_obo_namespace: disease_ontology
id: DOID:2537

Landau-Kleffner syndrome
type: Class
subclass of: childhood electroclinical syndrome
imported from: doid.owl
has cross-reference: GARD:6855
has cross-reference: ICD10CM:G40.8
has cross-reference: MESH:D018887
has cross-reference: NCI:C84806
has cross-reference: OMIM:245570
has cross-reference: ORDO:98818
has cross-reference: SNOMEDCT_US_2020_03_01:230438007
has cross-reference: UMLS_CUI:C0282512
alternative_term: acquired epileptic aphasia
has_obo_namespace: disease_ontology
id: DOID:2538
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

extratemporal epilepsy
type: Class
subclass of: epilepsy
textual definition: An epilepsy syndrome that is located_in an area of the brain other than the temporal lobe.
imported from: doid.owl
has cross-reference: NCI:C7760
has cross-reference: SNOMEDCT_US_2020_03_01:111498005
has cross-reference: UMLS_CUI:C0270849
alternative_term: Extratemporal epilepsy
has_obo_namespace: disease_ontology
id: DOID:2544
in subset: NCIthesaurus

hemangioma
type: Class
subclass of: cell type benign neoplasm
subclass of: cardiovascular organ benign neoplasm
subclass of: vascular disease
textual definition: A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.
imported from: doid.owl
has cross-reference: ICD10CM:D18.0
has cross-reference: ICD9CM:228.00
has cross-reference: MESH:D006391
has cross-reference: NCI:C3085
has cross-reference: SNOMEDCT_US_2020_03_01:154625006
has cross-reference: UMLS_CUI:C0018916
has_obo_namespace: disease_ontology
id: DOID:255
in subset: NCIthesaurus

relapsing polychondritis
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: chondromalacia
textual definition: A chondromalacia that is characterized by recurrent inflammation of cartilage and other tissues throughout the body.
imported from: doid.owl
has cross-reference: GARD:7417
has cross-reference: ICD10CM:M94.1
has cross-reference: MESH:D011081
has cross-reference: NCI:C157268
has cross-reference: SNOMEDCT_US_2020_03_01:72275000
has cross-reference: UMLS_CUI:C0032453
alternative_term: Chondromalacia, systemic
has_obo_namespace: disease_ontology
id: DOID:2556

chondromalacia
type: Class
subclass of: articular cartilage disease
textual definition: A cartilage disease that is characterized by softening and breakdown of cartilage inside a joint.
imported from: doid.owl
has cross-reference: ICD10CM:M94.2
has cross-reference: ICD9CM:733.92
has cross-reference: MESH:D002357
has cross-reference: SNOMEDCT_US_2020_03_01:63198006
has cross-reference: UMLS_CUI:C0085700
has_obo_namespace: disease_ontology
id: DOID:2557

opiate dependence
type: Class
subclass of: DOID 9974
textual definition: A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.
imported from: doid.owl
has cross-reference: ICD10CM:F11.2
has cross-reference: ICD9CM:304.00
has cross-reference: MESH:D009293
has cross-reference: SNOMEDCT_US_2020_03_01:75544000
has cross-reference: UMLS_CUI:C0524662
alternative_term: Opioid type dependence
has_obo_namespace: disease_ontology
id: DOID:2559

morphine dependence
type: Class
subclass of: opiate dependence
textual definition: An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.
imported from: doid.owl
has cross-reference: MESH:D009021
has cross-reference: SNOMEDCT_US_2020_03_01:286934009
has cross-reference: UMLS_CUI:C0026552
has_obo_namespace: disease_ontology
id: DOID:2560

macular corneal dystrophy
type: Class
subclass of: stromal dystrophy
textual definition: A corneal dystrophy that is characterized by corneal haze, bilateral loss of vision, eventually necessitating corneal transplantation resulting from progressive punctate opacities in the cornea.
imported from: doid.owl
has cross-reference: ICD10CM:H18.55
has cross-reference: ICD9CM:371.55
has cross-reference: MESH:D003317
has cross-reference: NCI:C34793
has cross-reference: OMIM:217800
has cross-reference: SNOMEDCT_US_2020_03_01:60258001
has cross-reference: UMLS_CUI:C0024439
alternative_term: Fehr corneal dystrophy
alternative_term: MACULAR DYSTROPHY, CORNEAL, 1
has_obo_namespace: disease_ontology
id: DOID:2565
in subset: NCIthesaurus

corneal dystrophy
type: Class
subclass of: corneal disease
imported from: doid.owl
has_alternative_id: DOID:8944
has cross-reference: ICD10CM:H18.5
has cross-reference: ICD9CM:371.5
has cross-reference: MESH:D003317
has cross-reference: NCI:C34512
has cross-reference: NCI:C34513
has cross-reference: SNOMEDCT_US_2020_03_01:5587004
has cross-reference: SNOMEDCT_US_2020_03_01:77797009
has cross-reference: UMLS_CUI:C0010035
has cross-reference: UMLS_CUI:C0010036
has_obo_namespace: disease_ontology
id: DOID:2566
in subset: NCIthesaurus

cervicitis
type: Class
subclass of: cervix disease
textual definition: A cervix disease that is characterized by inflammation of the cervix.
imported from: doid.owl
has_alternative_id: DOID:10110
has cross-reference: ICD10CM:N72
has cross-reference: ICD9CM:616.0
has cross-reference: MESH:D002575
has cross-reference: NCI:C26716
has cross-reference: SNOMEDCT_US_2020_03_01:198199009
has cross-reference: SNOMEDCT_US_2020_03_01:237081003
has cross-reference: UMLS_CUI:C0007860
has cross-reference: UMLS_CUI:C0007861
has_obo_namespace: disease_ontology
id: DOID:2568
in subset: NCIthesaurus

retinal drusen
type: Class
subclass of: degeneration of macula and posterior pole
imported from: doid.owl
has cross-reference: ICD9CM:362.57
has cross-reference: MESH:D015593
has cross-reference: SNOMEDCT_US_2020_03_01:141199000
has cross-reference: UMLS_CUI:C0035312
has_obo_namespace: disease_ontology
id: DOID:2569
comment: OMIM mapping confirmed by DO. [SN].

Langerhans-cell histiocytosis
type: Class
subclass of: histiocytosis
textual definition: A histiocytosis that is characterized by clonal proliferation of Langerhans cells.
imported from: doid.owl
has_alternative_id: DOID:10617
has_alternative_id: DOID:10618
has_alternative_id: DOID:10620
has_alternative_id: DOID:10623
has_alternative_id: DOID:10624
has_alternative_id: DOID:10625
has_alternative_id: DOID:2553
has_alternative_id: DOID:2554
has_alternative_id: DOID:9582
has cross-reference: ICD10CM:C96.0
has cross-reference: ICD10CM:C96.6
has cross-reference: ICD9CM:202.5
has cross-reference: MESH:C538636
has cross-reference: MESH:D006646
has cross-reference: NCI:C3107
has cross-reference: NCI:C3160
has cross-reference: OMIM:246400
has cross-reference: OMIM:604856
has cross-reference: SNOMEDCT_US_2020_03_01:154583006
has cross-reference: SNOMEDCT_US_2020_03_01:234439008
has cross-reference: UMLS_CUI:C0019621
has cross-reference: UMLS_CUI:C0023381
alternative_term: Histiocytosis X
alternative_term: Langerhan's cell histiocytosis
alternative_term: Langerhans cell granulomatosis
alternative_term: Letterer-Siwe disease
alternative_term: Letterer-Siwe disease involving intra-abdominal lymph nodes
alternative_term: Letterer-Siwe disease involving intrapelvic lymph nodes
alternative_term: Letterer-Siwe disease involving intrathoracic lymph nodes
alternative_term: Letterer-Siwe disease involving lymph nodes of axilla and upper limb
alternative_term: Letterer-Siwe disease involving lymph nodes of head, face and neck
alternative_term: Letterer-Siwe disease involving lymph nodes of head, face, and neck
alternative_term: Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb
alternative_term: Letterer-Siwe disease involving lymph nodes of multiple sites
alternative_term: Letterer-Siwe disease involving spleen
alternative_term: Letterer-Siwe disease of intra-abdominal lymph nodes
alternative_term: Letterer-Siwe disease of intrapelvic lymph nodes
alternative_term: Letterer-Siwe disease of intrathoracic lymph nodes
alternative_term: Letterer-Siwe disease of lymph nodes of axilla and upper limb
alternative_term: Letterer-Siwe disease of lymph nodes of axilla and/or upper limb
alternative_term: Letterer-Siwe disease of lymph nodes of head, face and neck
alternative_term: Letterer-Siwe disease of lymph nodes of head, face and/or neck
alternative_term: Letterer-Siwe disease of lymph nodes of inguinal region amd/or lower limb
alternative_term: Letterer-Siwe disease of lymph nodes of inguinal region and lower limb
alternative_term: Letterer-Siwe disease of lymph nodes of inguinal region and/or lower limb
alternative_term: Letterer-Siwe disease of lymph nodes of multiple sites
alternative_term: Letterer-Siwe disease of spleen
has_obo_namespace: disease_ontology
id: DOID:2571
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

barbiturate dependence
type: Class
subclass of: DOID 9974
textual definition: A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance.
imported from: doid.owl
has cross-reference: ICD9CM:304.11
has cross-reference: UMLS_CUI:C0154482
has_obo_namespace: disease_ontology
id: DOID:2575

rhizomelic chondrodysplasia punctata
type: Class
subclass of: autosomal recessive disease
subclass of: chondrodysplasia punctata
textual definition: A chondrodysplasia punctata that is characterized by disproportionately short stature primarily affecting the proximal parts of the extremities, a typical facial appearance including a broad nasal bridge, epicanthus, high-arched palate, dysplastic external ears, and micrognathia, congenital contractures, characteristic ocular involvement, dwarfism, and severe mental retardation with spasticity.
imported from: doid.owl
has cross-reference: GARD:13160
has cross-reference: ICD10CM:E71.540
has cross-reference: MESH:D018902
has cross-reference: NCI:C85047
has cross-reference: OMIM:PS215100
has cross-reference: ORDO:177
has cross-reference: SNOMEDCT_US_2020_03_01:56692003
has cross-reference: UMLS_CUI:C0282529
alternative_term: Chondrodysplasia Punctata, Rhizomelic Form
has_obo_namespace: disease_ontology
id: DOID:2580
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chondrodysplasia punctata
type: Class
subclass of: monogenic disease
subclass of: syndrome
textual definition: A syndrome that is characterized by abnormal calcification of the epiphyses, causing stippling in radiography.
imported from: doid.owl
has cross-reference: GARD:8542
has cross-reference: ICD10CM:Q77.3
has cross-reference: MESH:D002806
has cross-reference: NCI:C84632
has cross-reference: OMIM:215105
has cross-reference: ORDO:93442
has cross-reference: SNOMEDCT_US_2020_03_01:205486004
has cross-reference: UMLS_CUI:C0008445
alternative_term: Chondrodysplasia punctata congenita
has_obo_namespace: disease_ontology
id: DOID:2581
in subset: NCIthesaurus
comment: DeObs MGI.
has narrower match: MESH:D002806

acatalasia
type: Class
subclass of: DOID 906
imported from: doid.owl
has cross-reference: GARD:363
has cross-reference: MESH:D020642
has cross-reference: NCI:C84526
has cross-reference: OMIM:614097
has cross-reference: SNOMEDCT_US_2020_03_01:190954001
has cross-reference: UMLS_CUI:C0268419
alternative_term: deficiency of catalase
has_obo_namespace: disease_ontology
id: DOID:2582
in subset: NCIthesaurus

agammaglobulinemia
type: Class
subclass of: B cell deficiency
textual definition: A B cell deficiency that is caused by a reduction in all types of gamma globulins.
imported from: doid.owl
has_alternative_id: DOID:618
has cross-reference: ICD10CM:D80.1
has cross-reference: ICD9CM:279.00
has cross-reference: MESH:D000361
has cross-reference: NCI:C26931
has cross-reference: OMIM:601495
has cross-reference: OMIM:612692
has cross-reference: OMIM:613500
has cross-reference: OMIM:613501
has cross-reference: OMIM:615214
has cross-reference: OMIM:PS601495
has cross-reference: SNOMEDCT_US_2020_03_01:119250001
has cross-reference: SNOMEDCT_US_2020_03_01:267512002
has cross-reference: UMLS_CUI:C0001768
has cross-reference: UMLS_CUI:C0086438
alternative_term: IGHM
alternative_term: hypogammaglobulinemia
alternative_term: mu heavy chain deficiency
has_obo_namespace: disease_ontology
id: DOID:2583
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

glottis cancer
type: Class
subclass of: larynx cancer
imported from: doid.owl
has cross-reference: ICD10CM:C32.0
has cross-reference: ICD9CM:161.0
has cross-reference: NCI:C3544
has cross-reference: SNOMEDCT_US_2020_03_01:187841006
has cross-reference: UMLS_CUI:C0153483
alternative_term: Ca larynx - glottis
alternative_term: malignant tumor of glottis
alternative_term: malignant tumor of the Glottis
has_obo_namespace: disease_ontology
id: DOID:2595
in subset: NCIthesaurus

larynx cancer
type: Class
subclass of: respiratory system cancer
subclass of: laryngeal disease
textual definition: A respiratory system cancer that is located_in the larynx.
imported from: doid.owl
has cross-reference: GARD:6862
has cross-reference: ICD10CM:C32
has cross-reference: ICD9CM:161
has cross-reference: MESH:D007822
has cross-reference: NCI:C7484
has cross-reference: SNOMEDCT_US_2020_03_01:93859007
has cross-reference: UMLS_CUI:C0007107
has_obo_namespace: disease_ontology
id: DOID:2596
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

laryngeal benign neoplasm
type: Class
subclass of: respiratory system benign neoplasm
subclass of: laryngeal disease
imported from: doid.owl
has cross-reference: MESH:D007822
has cross-reference: NCI:C3156
has cross-reference: SNOMEDCT_US_2020_03_01:126692004
has cross-reference: UMLS_CUI:C0023055
alternative_term: laryngeal tumor
alternative_term: larynx neoplasm
alternative_term: neoplasm of larynx
has_obo_namespace: disease_ontology
id: DOID:2598
in subset: NCIthesaurus

glottis carcinoma
type: Class
subclass of: glottis cancer
subclass of: carcinoma
imported from: doid.owl
has cross-reference: NCI:C4923
has cross-reference: SNOMEDCT_US_2020_03_01:372103002
has cross-reference: UMLS_CUI:C0740083
alternative_term: Glottic carcinoma
alternative_term: carcinoma of glottis
has_obo_namespace: disease_ontology
id: DOID:2599
in subset: NCIthesaurus

pancreas disease
type: Class
subclass of: endocrine system disease
textual definition: An endocrine system disease that is located_in the pancreas.
imported from: doid.owl
has cross-reference: ICD10CM:K86.8
has cross-reference: ICD9CM:577.8
has cross-reference: SNOMEDCT_US_2020_03_01:197566002
has cross-reference: UMLS_CUI:C0029771
has_obo_namespace: disease_ontology
id: DOID:26

laryngeal carcinoma
type: Class
subclass of: larynx cancer
subclass of: carcinoma
textual definition: A larynx cancer that has_material_basis_in epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C4855
has cross-reference: SNOMEDCT_US_2020_03_01:154480006
has cross-reference: UMLS_CUI:C0595989
alternative_term: cancer of Larynx
alternative_term: cancer of larynx
alternative_term: carcinoma of larynx
has_obo_namespace: disease_ontology
id: DOID:2600
in subset: NCIthesaurus

chondroma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.
imported from: doid.owl
has cross-reference: GARD:6052
has cross-reference: MESH:D002812
has cross-reference: NCI:C53459
has cross-reference: SNOMEDCT_US_2020_03_01:269638002
has cross-reference: UMLS_CUI:C0936248
alternative_term: central Chondroma
has_obo_namespace: disease_ontology
id: DOID:2602
in subset: NCIthesaurus

papilloma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue.
imported from: doid.owl
has_alternative_id: DOID:1635
has cross-reference: MESH:D010212
has cross-reference: NCI:C3713
has cross-reference: NCI:C7440
has cross-reference: SNOMEDCT_US_2020_03_01:711329002
has cross-reference: SNOMEDCT_US_2020_03_01:82049002
has cross-reference: UMLS_CUI:C0030354
has cross-reference: UMLS_CUI:C0205875
alternative_term: papillomatosis
has_obo_namespace: disease_ontology
id: DOID:2615
in subset: NCIthesaurus

kidney hemangiopericytoma
type: Class
subclass of: kidney cancer
textual definition: A kidney cancer which is manifested in the kidney.
imported from: doid.owl
has cross-reference: NCI:C4527
has cross-reference: SNOMEDCT_US_2020_03_01:254923001
has cross-reference: UMLS_CUI:C0346256
alternative_term: hemangiopericytoma of kidney
alternative_term: renal hemangiopericytoma
has_obo_namespace: disease_ontology
id: DOID:262
in subset: NCIthesaurus

autonomic nervous system neoplasm
type: Class
subclass of: peripheral nervous system neoplasm
textual definition: A peripheral nervous system neoplasm that is located_in the autonomic nervous system.
imported from: doid.owl
has cross-reference: NCI:C5112
has cross-reference: UMLS_CUI:C1332356
alternative_term: tumor of Autonomic nervous system
has_obo_namespace: disease_ontology
id: DOID:2621
in subset: NCIthesaurus

choroid plexus papilloma
type: Class
subclass of: papilloma
subclass of: cerebrovascular benign neoplasm
imported from: doid.owl
has_alternative_id: DOID:3661
has cross-reference: GARD:4214
has cross-reference: MESH:D020288
has cross-reference: NCI:C3698
has cross-reference: NCI:C5800
has cross-reference: OMIM:260500
has cross-reference: SNOMEDCT_US_2020_03_01:18021007
has cross-reference: UMLS_CUI:C0205770
has cross-reference: UMLS_CUI:C1332963
alternative_term: childhood choroid plexus papilloma
has_obo_namespace: disease_ontology
id: DOID:2626
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

kidney cancer
type: Class
subclass of: urinary system cancer
subclass of: kidney disease
textual definition: A urinary system cancer that is located_in the kidney.
imported from: doid.owl
has_alternative_id: DOID:11834
has_alternative_id: DOID:3676
has cross-reference: ICD10CM:C64
has cross-reference: ICD9CM:189.0
has cross-reference: MESH:D007680
has cross-reference: NCI:C120456
has cross-reference: NCI:C3150
has cross-reference: NCI:C7548
has cross-reference: SNOMEDCT_US_2020_03_01:126880001
has cross-reference: SNOMEDCT_US_2020_03_01:93849006
has cross-reference: UMLS_CUI:C0022665
has cross-reference: UMLS_CUI:C0494158
has cross-reference: UMLS_CUI:C0740457
alternative_term: malignant neoplasm of kidney except pelvis
alternative_term: malignant tumour of kidney
alternative_term: renal cancer
has_obo_namespace: disease_ontology
id: DOID:263
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

cystadenoma
type: Class
subclass of: adenoma
textual definition: An adenoma that forms a cyst.
imported from: doid.owl
has cross-reference: MESH:D003537
has cross-reference: NCI:C2972
has cross-reference: SNOMEDCT_US_2020_03_01:189680006
has cross-reference: UMLS_CUI:C0010633
alternative_term: Cystadenoma
alternative_term: Cystoma
has_obo_namespace: disease_ontology
id: DOID:2634
in subset: NCIthesaurus

ovarian Brenner tumor
type: Class
subclass of: ovarian benign neoplasm
textual definition: An ovarian benign neoplasm that has_material_basis_in the surface epithelium of the ovary.
imported from: doid.owl
has cross-reference: GARD:9397
has cross-reference: MESH:D001948
has cross-reference: NCI:C39954
has cross-reference: SNOMEDCT_US_2020_03_01:74739000
has cross-reference: UMLS_CUI:C0006160
alternative_term: benign ovarian Brenner tumor
alternative_term: benign ovarian Brenner tumour
alternative_term: ovarian Brenner tumour
has_obo_namespace: disease_ontology
id: DOID:2636
in subset: NCIthesaurus

breast pericanalicular fibroadenoma
type: Class
subclass of: breast fibroadenoma
textual definition: A breast fibroadenoma that is characterized by stromal proliferation around epithelial structures.
imported from: doid.owl
has cross-reference: NCI:C4272
has cross-reference: SNOMEDCT_US_2020_03_01:41382006
has cross-reference: UMLS_CUI:C0334497
alternative_term: Pericanalicular Fibroadenoma of breast
alternative_term: Pericanalicular fibroadenoma
has_obo_namespace: disease_ontology
id: DOID:2639
in subset: NCIthesaurus

hemangiopericytoma
type: Class
subclass of: connective tissue cancer
textual definition: A soft tissue cancer that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries.
imported from: doid.owl
has_alternative_id: DOID:5372
has cross-reference: GARD:2627
has cross-reference: MESH:D006393
has cross-reference: NCI:C3087
has cross-reference: SNOMEDCT_US_2020_03_01:134335004
has cross-reference: UMLS_CUI:C0018922
alternative_term: Haemangiopericytic meningioma
alternative_term: hemangiopericytoma, malignant
alternative_term: malignant hemangiopericytoma
has_obo_namespace: disease_ontology
id: DOID:264
in subset: NCIthesaurus

struma ovarii
type: Class
subclass of: ovarian germ cell monodermal and highly specialized teratoma
textual definition: An ovarian germ cell monodermal and highly specialized teratoma that is composed either exclusively or predominantly of thyroid tissue.
imported from: doid.owl
has cross-reference: MESH:D013330
has cross-reference: NCI:C7468
has cross-reference: SNOMEDCT_US_2020_03_01:24327009
has cross-reference: UMLS_CUI:C0038478
alternative_term: Struma ovarii
has_obo_namespace: disease_ontology
id: DOID:2640
in subset: NCIthesaurus

ovarian germ cell monodermal and highly specialized teratoma
type: Class
subclass of: monodermal teratoma
textual definition: A monodermal teratoma that has_material_basis in germ cells that are highly specialized and is located_in the ovary.
imported from: doid.owl
has cross-reference: NCI:C8113
has cross-reference: UMLS_CUI:C0280134
alternative_term: Ovarian Monodermal and Highly Specialized teratoma
has_obo_namespace: disease_ontology
id: DOID:2641
in subset: NCIthesaurus

perivascular epithelioid cell tumor
type: Class
subclass of: perivascular tumor
imported from: doid.owl
has cross-reference: MESH:D054973
has cross-reference: NCI:C38150
has cross-reference: SNOMEDCT_US_2020_03_01:388601000
has cross-reference: UMLS_CUI:C1300127
alternative_term: PEComa
alternative_term: neoplasm with Perivascular epithelioid cell differentiation
has_obo_namespace: disease_ontology
id: DOID:2643
in subset: NCIthesaurus

benign mesothelioma
type: Class
subclass of: angiomyolipoma
textual definition: A cell type benign neoplasm that has_material_basis_in mesothelium.
imported from: doid.owl
has_alternative_id: DOID:2644
has cross-reference: ICD10CM:C45
has cross-reference: MESH:D008654
has cross-reference: NCI:C3234
has cross-reference: SNOMEDCT_US_2020_03_01:154491004
has cross-reference: UMLS_CUI:C0025500
alternative_term: benign tumor of Mesothelium
has_obo_namespace: disease_ontology
id: DOID:2645
in subset: NCIthesaurus

parachordoma
type: Class
subclass of: mesenchymal cell neoplasm
imported from: doid.owl
has cross-reference: NCI:C6581
has cross-reference: SNOMEDCT_US_2020_03_01:404086000
has cross-reference: UMLS_CUI:C1266175
has_obo_namespace: disease_ontology
id: DOID:2647
in subset: NCIthesaurus

sebaceous adenoma
type: Class
subclass of: sebaceous gland neoplasm
imported from: doid.owl
has_alternative_id: DOID:7387
has cross-reference: NCI:C4174
has cross-reference: SNOMEDCT_US_2020_03_01:78424008
has cross-reference: UMLS_CUI:C1368816
alternative_term: Sebaceous adenoma
alternative_term: adenoma of the Sebaceous gland
alternative_term: skin appendage sebaceous adenoma
has_obo_namespace: disease_ontology
id: DOID:2648
in subset: NCIthesaurus

chondroblastoma
type: Class
subclass of: cell type benign neoplasm
subclass of: connective tissue benign neoplasm
textual definition: A connective tissue benign neoplasm that derives_from chondroblasts and begins in cartilage at the ends of long bones (thighbone, shinbone, humerus) close to the joints.
imported from: doid.owl
has cross-reference: GARD:6047
has cross-reference: MESH:D002804
has cross-reference: NCI:C2945
has cross-reference: SNOMEDCT_US_2020_03_01:9001003
has cross-reference: UMLS_CUI:C0008441
alternative_term: Chondroblastoma of bone
has_obo_namespace: disease_ontology
id: DOID:2649
in subset: NCIthesaurus

dermoid cyst
type: Class
subclass of: cystic teratoma
textual definition: A cystic teratoma that is composed exclusively of mature tissues derived from two or three germ layers (ectoderm, mesoderm and endoderm).
imported from: doid.owl
has cross-reference: ICD10CM:K09.8
has cross-reference: MESH:D003884
has cross-reference: NCI:C9011
has cross-reference: SNOMEDCT_US_2020_03_01:189117002
has cross-reference: UMLS_CUI:C0011649
alternative_term: Dermoid choristoma
alternative_term: Dermoid tumour
alternative_term: Mature cystic teratoma
alternative_term: cystic dermoid choristoma
alternative_term: teratoma, benign
has_obo_namespace: disease_ontology
id: DOID:2658
in subset: NCIthesaurus

cystic teratoma
type: Class
subclass of: benign teratoma
textual definition: A benign teratoma that is characterized by the presence of cysts or cystic spaces.
imported from: doid.owl
has cross-reference: NCI:C9014
has cross-reference: SNOMEDCT_US_2020_03_01:42717009
has cross-reference: UMLS_CUI:C1368903
has_obo_namespace: disease_ontology
id: DOID:2660
in subset: NCIthesaurus

myoepithelioma
type: Class
subclass of: sweat gland benign neoplasm
textual definition: A sweat gland benign neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland.
imported from: doid.owl
has cross-reference: MESH:D009208
has cross-reference: NCI:C40392
has cross-reference: SNOMEDCT_US_2020_03_01:69291002
has cross-reference: UMLS_CUI:C0027070
alternative_term: Myoepithelial adenoma
alternative_term: Myoepithelial neoplasm
alternative_term: benign myoepithelioma
has_obo_namespace: disease_ontology
id: DOID:2661
in subset: NCIthesaurus

sweat gland benign neoplasm
type: Class
subclass of: sweat gland disease
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D013544
has cross-reference: NCI:C3398
has cross-reference: SNOMEDCT_US_2020_03_01:126490003
has cross-reference: UMLS_CUI:C0038987
alternative_term: Sweat gland tumor
alternative_term: neoplasm of sweat gland
alternative_term: tumor of the Sweat gland
has_obo_namespace: disease_ontology
id: DOID:2664
in subset: NCIthesaurus

mesenchymoma
type: Class
subclass of: connective tissue cancer
imported from: doid.owl
has cross-reference: MESH:D008637
has cross-reference: NCI:C3233
has cross-reference: SNOMEDCT_US_2020_03_01:44524009
has cross-reference: UMLS_CUI:C0025464
has_obo_namespace: disease_ontology
id: DOID:2668
in subset: NCIthesaurus

transitional cell carcinoma
type: Class
subclass of: carcinoma
textual definition: A carcinoma that derives_from transitional epithelial cells.
imported from: doid.owl
has_alternative_id: DOID:3995
has cross-reference: GARD:7794
has cross-reference: MESH:D002295
has cross-reference: NCI:C2930
has cross-reference: NCI:C6783
has cross-reference: SNOMEDCT_US_2020_03_01:118287003
has cross-reference: SNOMEDCT_US_2020_03_01:27090000
has cross-reference: UMLS_CUI:C0007138
has cross-reference: UMLS_CUI:C0334265
alternative_term: transitional carcinoma
alternative_term: transitional cell tumor
alternative_term: urothelial cell carcinoma
has_obo_namespace: disease_ontology
has_related_synonym: transitional cell neoplasm
id: DOID:2671
in subset: NCIthesaurus

adult cystic nephroma
type: Class
subclass of: nephroma
textual definition: A nephroma that is characterized as a localized, well-circumscribed multilocular tumor lined by hobnail epithelium.
imported from: doid.owl
has cross-reference: NCI:C7504
alternative_term: multilocular cystic nephroma, mixed epithelial stromal tumour and renal epithelial stromal tumour
has_obo_namespace: disease_ontology
id: DOID:2673

dysembryoplastic neuroepithelial tumor
type: Class
subclass of: central nervous system benign neoplasm
imported from: doid.owl
has cross-reference: GARD:10640
has cross-reference: NCI:C9505
has cross-reference: SNOMEDCT_US_2020_03_01:87211000119104
has cross-reference: UMLS_CUI:C1266177
alternative_term: Dysembryoplastic Neuroepithelial neoplasm
alternative_term: Dysembryoplastic neuroepithelial tumor
alternative_term: Dysembryoplastic neuroepithelial tumour
alternative_term: dysembryoplastic neuroepithelial tumour
has_obo_namespace: disease_ontology
id: DOID:2679
in subset: NCIthesaurus

adenofibroma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands.
imported from: doid.owl
has cross-reference: MESH:D000232
has cross-reference: SNOMEDCT_US_2020_03_01:189823009
has cross-reference: UMLS_CUI:C0001422
has_obo_namespace: disease_ontology
id: DOID:2683

ossifying fibromyxoid tumor
type: Class
subclass of: mesenchymal cell neoplasm
imported from: doid.owl
has cross-reference: NCI:C6582
has cross-reference: SNOMEDCT_US_2020_03_01:404076001
has cross-reference: UMLS_CUI:C1266128
alternative_term: Ossifying Fibromyxoma
alternative_term: Ossifying fibromyxoid tumor
alternative_term: Ossifying fibromyxoid tumour
alternative_term: ossifying fibromyxoid tumour
has_obo_namespace: disease_ontology
id: DOID:2685
in subset: NCIthesaurus

lymphangiosarcoma
type: Class
subclass of: lymphatic system cancer
textual definition: A lymphatic system cancer that has_material_basis_in endothelial cells located_in lymphatic vessels.
imported from: doid.owl
has_alternative_id: DOID:2686
has cross-reference: MESH:C537491
has cross-reference: MESH:D008204
has cross-reference: NCI:C3205
has cross-reference: NCI:C4490
has cross-reference: SNOMEDCT_US_2020_03_01:403986008
has cross-reference: SNOMEDCT_US_2020_03_01:62497000
has cross-reference: UMLS_CUI:C0024224
has cross-reference: UMLS_CUI:C0346082
alternative_term: Lymphangiosarcoma of Stewart and Treves
alternative_term: Stewart-Treves syndrome
alternative_term: malignant Lymphangioendothelioma
alternative_term: skin lymphangiosarcoma
has_obo_namespace: disease_ontology
id: DOID:2689
in subset: NCIthesaurus

myoma
type: Class
subclass of: uterine benign neoplasm
subclass of: muscle benign neoplasm
textual definition: A muscle benign neoplasm that is characterized as benign hyperplastic lesions of uterine smooth muscle cells.
imported from: doid.owl
has cross-reference: ICD10CM:D21
has cross-reference: MESH:D009214
has cross-reference: NCI:C4882
has cross-reference: SNOMEDCT_US_2020_03_01:66357004
has cross-reference: UMLS_CUI:C0027086
alternative_term: benign neoplasm of the Muscle
has_obo_namespace: disease_ontology
id: DOID:2691
in subset: NCIthesaurus

Leydig cell tumor
type: Class
subclass of: sex cord-gonadal stromal tumor
textual definition: A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located_in ovary or testicle.
imported from: doid.owl
has_alternative_id: DOID:0050616
has cross-reference: MESH:D007984
has cross-reference: NCI:C3188
has cross-reference: NCI:C4213
has cross-reference: SNOMEDCT_US_2020_03_01:45002009
has cross-reference: SNOMEDCT_US_2020_03_01:77870005
has cross-reference: UMLS_CUI:C0023601
has cross-reference: UMLS_CUI:C0334410
alternative_term: Leydig cell neoplasm
has_obo_namespace: disease_ontology
id: DOID:2696
in subset: NCIthesaurus

renal adenoma
type: Class
subclass of: kidney benign neoplasm
subclass of: adenoma
imported from: doid.owl
has cross-reference: NCI:C8383
has cross-reference: SNOMEDCT_US_2020_03_01:41627005
has cross-reference: UMLS_CUI:C0334684
alternative_term: renal cell adenoma
has_obo_namespace: disease_ontology
id: DOID:2697
in subset: NCIthesaurus

nephrogenic adenofibroma
type: Class
subclass of: kidney benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C39812
has cross-reference: SNOMEDCT_US_2020_03_01:128760004
has cross-reference: UMLS_CUI:C1266141
alternative_term: Metanephric adenofibroma
has_obo_namespace: disease_ontology
id: DOID:2698
in subset: NCIthesaurus

liver sarcoma
type: Class
subclass of: liver cancer
textual definition: A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver.
imported from: doid.owl
has cross-reference: NCI:C4437
has cross-reference: SNOMEDCT_US_2020_03_01:254601002
has cross-reference: UMLS_CUI:C0345906
alternative_term: hepatic sarcoma
has_obo_namespace: disease_ontology
id: DOID:270
in subset: NCIthesaurus

nodular tenosynovitis
type: Class
subclass of: connective tissue benign neoplasm
imported from: doid.owl
has_alternative_id: DOID:2665
has cross-reference: MESH:D000070779
has cross-reference: NCI:C3829
has cross-reference: NCI:C6532
has cross-reference: SNOMEDCT_US_2020_03_01:5178002
has cross-reference: SNOMEDCT_US_2020_03_01:71508003
has cross-reference: UMLS_CUI:C0221289
has cross-reference: UMLS_CUI:C0588125
alternative_term: Synovioma, benign
alternative_term: benign synovioma
alternative_term: benign tumor of Synovium
alternative_term: localized Giant cell tumor of Tenosynovium
has_obo_namespace: disease_ontology
id: DOID:2701
in subset: NCIthesaurus

pigmented villonodular synovitis
type: Class
subclass of: synovitis
imported from: doid.owl
has cross-reference: GARD:7396
has cross-reference: ICD10CM:M12.2
has cross-reference: MESH:D013586
has cross-reference: NCI:C3401
has cross-reference: SNOMEDCT_US_2020_03_01:202903009
has cross-reference: UMLS_CUI:C0039106
alternative_term: Diffuse Giant cell tumor of Tenosynovium
alternative_term: villous tenosynovitis
has_obo_namespace: disease_ontology
id: DOID:2702
in subset: NCIthesaurus

synovitis
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.
imported from: doid.owl
has cross-reference: GARD:7722
has cross-reference: MESH:D013585
has cross-reference: NCI:C50766
has cross-reference: SNOMEDCT_US_2020_03_01:268092005
has cross-reference: UMLS_CUI:C0039103
has_obo_namespace: disease_ontology
id: DOID:2703
in subset: NCIthesaurus

synovium cancer
type: Class
subclass of: connective tissue cancer
imported from: doid.owl
has cross-reference: NCI:C6531
has cross-reference: UMLS_CUI:C1334624
alternative_term: malignant tumor of Synovium
has_obo_namespace: disease_ontology
id: DOID:2706
in subset: NCIthesaurus

sick building syndrome
type: Class
subclass of: extrinsic allergic alveolitis
textual definition: An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.
imported from: doid.owl
has cross-reference: MESH:D018877
has cross-reference: SNOMEDCT_US_2020_03_01:19076009
has cross-reference: UMLS_CUI:C0037050
has_obo_namespace: disease_ontology
id: DOID:2710

phimosis
type: Class
subclass of: penile disease
imported from: doid.owl
has cross-reference: ICD10CM:N47.1
has cross-reference: MESH:D010688
has cross-reference: NCI:C26852
has cross-reference: SNOMEDCT_US_2020_03_01:449826002
has cross-reference: UMLS_CUI:C0031538
alternative_term: Tight foreskin
alternative_term: Tight frenulum
has_obo_namespace: disease_ontology
id: DOID:2712
in subset: NCIthesaurus

Bloom syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability.
imported from: doid.owl
has cross-reference: MESH:D001816
has cross-reference: NCI:C2903
has cross-reference: OMIM:210900
has cross-reference: ORDO:125
has cross-reference: SNOMEDCT_US_2020_03_01:4434006
has cross-reference: UMLS_CUI:C0005859
alternative_term: Bloom-Torre-Machacek syndrome
alternative_term: Congenital Telangiectatic Erythema syndrome
has_obo_namespace: disease_ontology
id: DOID:2717
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hemopneumothorax
type: Class
subclass of: pneumothorax
textual definition: A pneumothorax that is characterized by having air in the chest cavity and blood in the chest cavity.
imported from: doid.owl
has cross-reference: ICD10CM:J94.2
has cross-reference: MESH:D006468
has cross-reference: SNOMEDCT_US_2020_03_01:16632002
has cross-reference: UMLS_CUI:C0019077
alternative_term: haemopneumothorax
has_obo_namespace: disease_ontology
id: DOID:2718

hepatic vascular disease
type: Class
subclass of: vascular disease
subclass of: liver disease
textual definition: A vascular disease that is located_in the liver.
imported from: doid.owl
has cross-reference: NCI:C35442
has cross-reference: SNOMEDCT_US_2020_03_01:235878005
has cross-reference: UMLS_CUI:C0400923
alternative_term: vascular disorder of liver
has_obo_namespace: disease_ontology
id: DOID:272
in subset: NCIthesaurus

acrodermatitis
type: Class
subclass of: dermatitis
textual definition: A dermatitis that selectively affects the hands and feet.
imported from: doid.owl
has cross-reference: GARD:5722
has cross-reference: MESH:D000169
has cross-reference: NCI:C84532
has cross-reference: SNOMEDCT_US_2020_03_01:8197001
has cross-reference: UMLS_CUI:C0001197
has_obo_namespace: disease_ontology
id: DOID:2722
in subset: NCIthesaurus

dermatitis
type: Class
subclass of: skin disease
textual definition: A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin.
imported from: doid.owl
has_alternative_id: DOID:8614
has_alternative_id: DOID:8917
has cross-reference: ICD10CM:L30.9
has cross-reference: MESH:D003872
has cross-reference: NCI:C2983
has cross-reference: SNOMEDCT_US_2020_03_01:238538009
has cross-reference: UMLS_CUI:C0011603
alternative_term: eczema
alternative_term: skin inflammation
has_obo_namespace: disease_ontology
id: DOID:2723
in subset: NCIthesaurus

capillary hemangioma
type: Class
subclass of: capillary disease
imported from: doid.owl
has cross-reference: ICD10CM:Q82.5
has cross-reference: MESH:D018324
has cross-reference: NCI:C7457
has cross-reference: SNOMEDCT_US_2020_03_01:56975005
has cross-reference: UMLS_CUI:C0206733
alternative_term: Capillary hemangioma
alternative_term: Congenital vascular hamartoma
alternative_term: Congenital vascular naevus
alternative_term: Infantile hemangioma
alternative_term: Juvenile hemangioma
alternative_term: Strawberry haemangioma
alternative_term: Strawberry nevus
alternative_term: Strawberry nevus of skin
alternative_term: cellular hemangioma of Infancy
has_obo_namespace: disease_ontology
id: DOID:2725
in subset: NCIthesaurus

dyskeratosis congenita
type: Class
subclass of: skin disease
textual definition: A skin disease characterized by cutaneous pigmentation, premature graying, dystrophy of the nails, leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts, often thrombocytopenia, anemia, testicular atrophy in the male carriers and predisposition to cancer.
imported from: doid.owl
has cross-reference: GARD:10905
has cross-reference: MESH:D019871
has cross-reference: NCI:C111802
has cross-reference: OMIM:PS127550
has cross-reference: ORDO:1775
has cross-reference: SNOMEDCT_US_2020_03_01:74911008
has cross-reference: UMLS_CUI:C0265965
has_obo_namespace: disease_ontology
id: DOID:2729
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping by NeuroDevNet. [LS].

epidermolysis bullosa
type: Class
subclass of: vesiculobullous skin disease
textual definition: A vesiculobullous skin disease that is characterized by formation of blisters with only minor skin trauma, which can cause widespread wounds, dehydration, electrolyte abnormalities, and severe infection, frequently develops_from mutations in connective tissue elements, including genes encoding keratin, collagen, and laminin.
imported from: doid.owl
has cross-reference: GARD:6359
has cross-reference: ICD10CM:Q81
has cross-reference: MESH:D004820
has cross-reference: NCI:C67383
has cross-reference: SNOMEDCT_US_2020_03_01:205580008
has cross-reference: UMLS_CUI:C0014527
alternative_term: Epidermolysis bullosa
alternative_term: acantholysis bullosa
has_obo_namespace: disease_ontology
id: DOID:2730
in subset: NCIthesaurus

vesiculobullous skin disease
type: Class
subclass of: skin disease
textual definition: A skin disease that is characterized by fluid filled blisters.
imported from: doid.owl
has cross-reference: MESH:D012872
has cross-reference: UMLS_CUI:C0037275
has_obo_namespace: disease_ontology
id: DOID:2731

Rothmund-Thomson syndrome
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: GARD:4392
has cross-reference: ICD10CM:Q82.8
has cross-reference: MESH:D011038
has cross-reference: NCI:C3335
has cross-reference: OMIM:268400
has cross-reference: SNOMEDCT_US_2020_03_01:205572001
has cross-reference: UMLS_CUI:C0032339
alternative_term: Congenital poikiloderma
alternative_term: RTS
has_obo_namespace: disease_ontology
id: DOID:2732
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

skin atrophy
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: ICD10CM:L90
has cross-reference: NCI:C35163
has cross-reference: SNOMEDCT_US_2020_03_01:16343004
has cross-reference: UMLS_CUI:C0151514
alternative_term: Atrophoderma
alternative_term: Atrophy - skin
alternative_term: atrophic condition of skin
has_obo_namespace: disease_ontology
id: DOID:2733
in subset: NCIthesaurus

keratosis follicularis
type: Class
subclass of: keratosis
imported from: doid.owl
has cross-reference: ICD10CM:E50.8
has cross-reference: MESH:D007644
has cross-reference: NCI:C84665
has cross-reference: OMIM:124200
has cross-reference: SNOMEDCT_US_2020_03_01:157017000
has cross-reference: UMLS_CUI:C0022595
alternative_term: DARIER-WHITE DISEASE
alternative_term: Darier's disease
alternative_term: Keratosis follicularis
has_obo_namespace: disease_ontology
id: DOID:2734
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Hajdu-Cheney syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: bone disease
textual definition: A bone disease characterized by short stature, coarse and dysmorphic facies, bowing of the long bones, and vertebral anomalies that has_material_basis_in heterozygous mutation in NOTCH2 on chromosome 1p12.
imported from: doid.owl
has_alternative_id: DOID:2735
has cross-reference: GARD:508
has cross-reference: MESH:D030981
has cross-reference: MESH:D031845
has cross-reference: NCI:C35545
has cross-reference: NCI:C84745
has cross-reference: OMIM:102500
has cross-reference: SNOMEDCT_US_2020_03_01:63122002
has cross-reference: UMLS_CUI:C0917715
has cross-reference: UMLS_CUI:C0917990
alternative_term: Cheney syndrome
alternative_term: HJCYS
alternative_term: SFPKS
alternative_term: acroosteolysis with osteoporosis and changes in skull and mandible
alternative_term: arthrodentoosteodysplasia
alternative_term: serpentine fibula-polycystic kidney syndrome
has_obo_namespace: disease_ontology
id: DOID:2736
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pseudoxanthoma elasticum
type: Class
subclass of: autosomal recessive disease
subclass of: connective tissue disease
textual definition: A connective tissue disease that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system.
imported from: doid.owl
has cross-reference: GARD:9643
has cross-reference: MESH:D011561
has cross-reference: NCI:C85036
has cross-reference: OMIM:177850
has cross-reference: OMIM:264800
has cross-reference: ORDO:758
has cross-reference: SNOMEDCT_US_2020_03_01:7109007
has cross-reference: UMLS_CUI:C0033847
alternative_term: Gronblad-Strandberg syndrome
has_obo_namespace: disease_ontology
id: DOID:2738
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Gilbert syndrome
type: Class
subclass of: bilirubin metabolic disorder
textual definition: A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity.
imported from: doid.owl
has cross-reference: GARD:6507
has cross-reference: ICD10CM:E80.4
has cross-reference: MESH:D005878
has cross-reference: NCI:C84729
has cross-reference: OMIM:143500
has cross-reference: SNOMEDCT_US_2020_03_01:27503000
has cross-reference: UMLS_CUI:C0017551
alternative_term: Constitutional hyperbilirubinemia
alternative_term: Gilbert's disease
alternative_term: Gilbert's syndrome
alternative_term: Gilbert-Meulengracht syndrome
alternative_term: hereditary nonhemolytic jaundice
has_obo_namespace: disease_ontology
id: DOID:2739
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

bilirubin metabolic disorder
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism.
imported from: doid.owl
has_alternative_id: DOID:2740
has cross-reference: MESH:D006932
has cross-reference: MESH:D006933
has cross-reference: NCI:C84761
has cross-reference: SNOMEDCT_US_2020_03_01:154770008
has cross-reference: UMLS_CUI:C0020433
has cross-reference: UMLS_CUI:C0020435
alternative_term: hereditary hyperbilirubinemia
alternative_term: hyperbilirubinemia
has_obo_namespace: disease_ontology
has_related_synonym: hyperbilirubinaemia
id: DOID:2741
in subset: NCIthesaurus

auditory system disease
type: Class
subclass of: sensory system disease
textual definition: A sensory system disease that is characterized by auditory dysfunction located_in the auditory system.
imported from: doid.owl
has_alternative_id: DOID:1490
has_alternative_id: DOID:2011
has cross-reference: ICD10CM:H93.9
has cross-reference: ICD9CM:388.9
has cross-reference: MESH:D004427
has cross-reference: NCI:C26757
has cross-reference: SNOMEDCT_US_2020_03_01:194193002
has cross-reference: UMLS_CUI:C0013447
alternative_term: ear and mastoid disease
has_obo_namespace: disease_ontology
id: DOID:2742
in subset: DO FlyBase slim
in subset: NCIthesaurus

pyelitis
type: Class
subclass of: kidney disease
imported from: doid.owl
has cross-reference: ICD10CM:N12
has cross-reference: MESH:D011702
has cross-reference: NCI:C34964
has cross-reference: SNOMEDCT_US_2020_03_01:27174002
has cross-reference: UMLS_CUI:C0034183
has_obo_namespace: disease_ontology
id: DOID:2744
in subset: NCIthesaurus

narcissistic personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity.
imported from: doid.owl
has cross-reference: ICD10CM:F60.81
has cross-reference: ICD9CM:301.81
has cross-reference: MESH:D010554
has cross-reference: NCI:C92635
has cross-reference: SNOMEDCT_US_2020_03_01:80711002
has cross-reference: UMLS_CUI:C0027402
has_obo_namespace: disease_ontology
id: DOID:2745
in subset: NCIthesaurus

glycogen storage disease V
type: Class
subclass of: glycogen storage disease
imported from: doid.owl
has cross-reference: GARD:6528
has cross-reference: ICD10CM:E74.04
has cross-reference: MESH:D006012
has cross-reference: NCI:C84738
has cross-reference: OMIM:232600
has cross-reference: SNOMEDCT_US_2020_03_01:55912009
has cross-reference: UMLS_CUI:C0017924
alternative_term: Glycogen storage disease, type V
alternative_term: McArdle's disease
alternative_term: glycogen storage disease type V
alternative_term: myophosphorylase deficiency
has_obo_namespace: disease_ontology
id: DOID:2746
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

glycogen storage disease
type: Class
subclass of: glycogen metabolism disorder
textual definition: A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.
imported from: doid.owl
has cross-reference: ICD10CM:E74.0
has cross-reference: ICD9CM:271.0
has cross-reference: MESH:D006008
has cross-reference: NCI:C61272
has cross-reference: SNOMEDCT_US_2020_03_01:267498002
has cross-reference: UMLS_CUI:C0017919
alternative_term: glycogenosis
has_narrow_synonym: glycogenoses
has_obo_namespace: disease_ontology
id: DOID:2747
in subset: NCIthesaurus

glycogen storage disease IV
type: Class
subclass of: glycogen storage disease
imported from: doid.owl
has cross-reference: GARD:2520
has cross-reference: ICD10CM:E74.09
has cross-reference: MESH:D006011
has cross-reference: NCI:C84737
has cross-reference: OMIM:232500
has cross-reference: SNOMEDCT_US_2020_03_01:11179002
has cross-reference: UMLS_CUI:C0017923
alternative_term: Amylopectinosis
alternative_term: Branching-transferase deficiency glycogenosis
alternative_term: Glycogen storage disease, type IV
alternative_term: brancher deficiency glycogenosis
alternative_term: deficiency of 1,4-alpha-glucan branching enzyme
has_obo_namespace: disease_ontology
id: DOID:2750
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

glycogen storage disease II
type: Class
subclass of: glycogen storage disease
textual definition: A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to an accumulation of glycogen in the lysosome.
imported from: doid.owl
has cross-reference: GARD:5714
has cross-reference: ICD10CM:E74.02
has cross-reference: MESH:D006009
has cross-reference: NCI:C84734
has cross-reference: OMIM:232300
has cross-reference: SNOMEDCT_US_2020_03_01:237967002
has cross-reference: UMLS_CUI:C0017921
alternative_term: Generalized glycogenosis
alternative_term: Glycogen storage disease, type II
alternative_term: Glycogenosis, type 2
alternative_term: Lysosomal alpha-1,4-glucosidase deficiency
alternative_term: Pompe's disease
alternative_term: acid maltase deficiency
alternative_term: deficiency of glucoamylase
alternative_term: deficiency of maltase
alternative_term: glycogen storage disease type II
has_obo_namespace: disease_ontology
id: DOID:2752
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Mycobacterium avium complex disease
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons.
imported from: doid.owl
has cross-reference: GARD:7123
has cross-reference: MESH:D015270
has cross-reference: NCI:C36197
has cross-reference: SNOMEDCT_US_2020_03_01:14009004
has cross-reference: UMLS_CUI:C0026916
alternative_term: Infection due to Mycobacterium intracellulare
alternative_term: MAC disease
alternative_term: Mycobacterium Avium Infection
alternative_term: Mycobacterium avium Complex
has_obo_namespace: disease_ontology
id: DOID:2755
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

tic disorder
type: Class
subclass of: specific developmental disorder
textual definition: A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.
imported from: doid.owl
has cross-reference: ICD10CM:F95
has cross-reference: ICD9CM:307.20
has cross-reference: MESH:D013981
has cross-reference: SNOMEDCT_US_2020_03_01:155005001
has cross-reference: UMLS_CUI:C0040188
has_obo_namespace: disease_ontology
id: DOID:2769

irritant dermatitis
type: Class
subclass of: contact dermatitis
textual definition: A contact dermatitis that is characterized by a cutaneous inflammatory reaction to repeated contact with an irritant substance, friction, liquid, or adverse temperature that interacts with the skin and often has_symptom erythema, edema, scaling, pain, pruritis, or burning sensation.
imported from: doid.owl
has cross-reference: ICD10CM:L24.9
has cross-reference: MESH:D017453
has cross-reference: NCI:C27151
has cross-reference: SNOMEDCT_US_2020_03_01:110979008
has cross-reference: UMLS_CUI:C0162823
alternative_term: Irritant Contact Dermatitis
alternative_term: Irritant contact dermatitis
alternative_term: primary irritant dermatitis
has_obo_namespace: disease_ontology
id: DOID:2772
in subset: NCIthesaurus

contact dermatitis
type: Class
subclass of: dermatitis
imported from: doid.owl
has cross-reference: ICD10CM:L25.9
has cross-reference: MESH:D003877
has cross-reference: NCI:C26743
has cross-reference: SNOMEDCT_US_2020_03_01:156338009
has cross-reference: UMLS_CUI:C0011616
alternative_term: Contact dermatitis
alternative_term: Contact dermatitis/eczema
alternative_term: Contact eczema
alternative_term: Dermatitis, venenata
alternative_term: dermatitis venenata
has_obo_namespace: disease_ontology
id: DOID:2773
in subset: NCIthesaurus

adamantinoma
type: Class
subclass of: bone cancer
textual definition: A bone cancer that is located_in almost exclusively in the long bones.
imported from: doid.owl
has cross-reference: MESH:D050398
has cross-reference: NCI:C7644
has cross-reference: ORDO:55881
has cross-reference: UMLS_CUI:C1367554
has_obo_namespace: disease_ontology
id: DOID:2776
in subset: NCIthesaurus

lung sarcoma
type: Class
subclass of: sarcoma
subclass of: lung cancer
textual definition: A lung cancer that is located_in the lung and that arises from transformed cells of mesenchymal origin.
imported from: doid.owl
has cross-reference: NCI:C4860
has cross-reference: UMLS_CUI:C0598790
alternative_term: pulmonary sarcoma
has_obo_namespace: disease_ontology
id: DOID:2784
in subset: NCIthesaurus

Dandy-Walker syndrome
type: Class
subclass of: cerebellar disease
textual definition: A cerebellar disease that is characterized by hypoplasia and upward rotation of the cerebellar vermis and cystic dilation of the fourth ventricle.
imported from: doid.owl
has cross-reference: GARD:6242
has cross-reference: ICD10CM:Q03.1
has cross-reference: MESH:D003616
has cross-reference: NCI:C75012
has cross-reference: OMIM:220200
has cross-reference: SNOMEDCT_US_2020_03_01:14447001
has cross-reference: UMLS_CUI:C0010964
alternative_term: Atresia of foramina of Magendie and Luschka
has_obo_namespace: disease_ontology
id: DOID:2785
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cerebellar disease
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome.
imported from: doid.owl
has cross-reference: MESH:D002526
has cross-reference: SNOMEDCT_US_2020_03_01:267691001
has cross-reference: UMLS_CUI:C0007760
has_obo_namespace: disease_ontology
id: DOID:2786

parasitic protozoa infectious disease
type: Class
subclass of: parasitic infectious disease
textual definition: A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.
imported from: doid.owl
has_alternative_id: DOID:0060003
has_alternative_id: DOID:10553
has_alternative_id: DOID:3734
has_alternative_id: DOID:3804
has_alternative_id: DOID:947
has cross-reference: ICD10CM:B64
has cross-reference: MESH:D011528
has cross-reference: NCI:C34953
has cross-reference: SNOMEDCT_US_2020_03_01:95896000
has cross-reference: UMLS_CUI:C0033740
alternative_term: mastigophora infectious disease
alternative_term: sarcomastigophora infectious disease
has_obo_namespace: disease_ontology
id: DOID:2789
in subset: NCIthesaurus

necatoriasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.
imported from: doid.owl
has_alternative_id: DOID:13048
has cross-reference: ICD10CM:B76.1
has cross-reference: MESH:D009332
has cross-reference: NCI:C34838
has cross-reference: SNOMEDCT_US_2020_03_01:36667009
has cross-reference: UMLS_CUI:C0027528
has_obo_namespace: disease_ontology
id: DOID:2790
in subset: NCIthesaurus

idiopathic interstitial pneumonia
type: Class
subclass of: pneumonia
textual definition: A pneumonia located_in the lung parenchyma of unknown cause.
imported from: doid.owl
has cross-reference: ICD10CM:J84.114
has cross-reference: MESH:D000080203
has cross-reference: SNOMEDCT_US_2020_03_01:129459004
has cross-reference: UMLS_CUI:C0085786
alternative_term: Diffuse idiopathic pulmonary fibrosis
alternative_term: Idiopathic fibrosing alveolitis
has_obo_namespace: disease_ontology
has_related_synonym: IPF
id: DOID:2797

bronchiolitis obliterans
type: Class
subclass of: bronchial disease
subclass of: interstitial lung disease
textual definition: A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.
imported from: doid.owl
has cross-reference: GARD:9551
has cross-reference: MESH:D001989
has cross-reference: NCI:C62580
has cross-reference: SNOMEDCT_US_2020_03_01:40100001
has cross-reference: UMLS_CUI:C0006272
alternative_term: Bronchiolitis exudativa
alternative_term: Bronchiolitis fibrosa obliterans
alternative_term: Obliterative bronchiolitis
has_obo_namespace: disease_ontology
id: DOID:2799
in subset: NCIthesaurus

endocrine system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.
imported from: doid.owl
has cross-reference: ICD10CM:E34.9
has cross-reference: ICD9CM:259.9
has cross-reference: MESH:D004700
has cross-reference: NCI:C3009
has cross-reference: SNOMEDCT_US_2020_03_01:67432001
has cross-reference: UMLS_CUI:C0014130
has_obo_namespace: disease_ontology
id: DOID:28
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

cranial nerve malignant neoplasm
type: Class
subclass of: cranial nerve neoplasm
imported from: doid.owl
has cross-reference: ICD10CM:C72.50
has cross-reference: ICD9CM:192.0
has cross-reference: MESH:D003390
has cross-reference: NCI:C3571
has cross-reference: SNOMEDCT_US_2020_03_01:188311003
has cross-reference: UMLS_CUI:C0153644
alternative_term: malignant neoplasm of cranial nerve
alternative_term: malignant neoplasm of cranial nerves
alternative_term: malignant tumor of cranial nerve
alternative_term: malignant tumor of the Cranial nerve
has_obo_namespace: disease_ontology
id: DOID:2815
in subset: NCIthesaurus

nose disease
type: Class
subclass of: DOID 974
imported from: doid.owl
has cross-reference: MESH:D009668
has cross-reference: SNOMEDCT_US_2020_03_01:89488007
has cross-reference: UMLS_CUI:C0028432
alternative_term: disorder of the nose
alternative_term: nasal disorder
has_obo_namespace: disease_ontology
id: DOID:2825

acalculous cholecystitis
type: Class
subclass of: cholecystitis
imported from: doid.owl
has_alternative_id: DOID:2827
has cross-reference: MESH:D042101
has cross-reference: NCI:C35578
has cross-reference: SNOMEDCT_US_2020_03_01:19968009
has cross-reference: UMLS_CUI:C0267841
alternative_term: acute acalculous cholecystitis
alternative_term: acute cholecystitis without calculus
alternative_term: cholecystitis without calculus
has_obo_namespace: disease_ontology
id: DOID:2828
in subset: NCIthesaurus

asthma
type: Class
subclass of: bronchial disease
textual definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.
imported from: doid.owl
has_alternative_id: DOID:12703
has_alternative_id: DOID:13829
has_alternative_id: DOID:13830
has_alternative_id: DOID:2840
has_alternative_id: DOID:5783
has cross-reference: EFO:0000270
has cross-reference: GARD:10246
has cross-reference: ICD10CM:J45
has cross-reference: ICD9CM:493
has cross-reference: KEGG:05310
has cross-reference: MESH:D001249
has cross-reference: NCI:C28397
has cross-reference: OMIM:600807
has cross-reference: SNOMEDCT_US_2020_03_01:187687003
has cross-reference: UMLS_CUI:C0004096
alternative_term: Exercise induced asthma
alternative_term: bronchial hyperreactivity
alternative_term: chronic obstructive asthma
alternative_term: chronic obstructive asthma with acute exacerbation
alternative_term: chronic obstructive asthma with status asthmaticus
alternative_term: exercise-induced asthma
has_obo_namespace: disease_ontology
id: DOID:2841
in subset: NCIthesaurus
comment: Xref MGI.

long QT syndrome
type: Class
subclass of: intrinsic cardiomyopathy
textual definition: An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).
imported from: doid.owl
has_alternative_id: DOID:4069
has cross-reference: GARD:6922
has cross-reference: ICD10CM:I45.81
has cross-reference: ICD9CM:426.82
has cross-reference: MESH:D008133
has cross-reference: NCI:C34786
has cross-reference: OMIM:PS192500
has cross-reference: ORDO:101016
has cross-reference: ORDO:768
has cross-reference: SNOMEDCT_US_2020_03_01:20852007
has cross-reference: SNOMEDCT_US_2020_03_01:9651007
has cross-reference: UMLS_CUI:C0023976
has cross-reference: UMLS_CUI:C0035828
alternative_term: LQT
alternative_term: Romano-Ward syndrome
alternative_term: long Q-T syndrome
has_obo_namespace: disease_ontology
id: DOID:2843
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

melancholia
type: Class
subclass of: mental depression
imported from: doid.owl
has cross-reference: MESH:D003866
has cross-reference: NCI:C34812
has cross-reference: SNOMEDCT_US_2020_03_01:35489007
has cross-reference: UMLS_CUI:C0025193
has_obo_namespace: disease_ontology
id: DOID:2848
in subset: NCIthesaurus

hairy cell leukemia
type: Class
subclass of: chronic lymphocytic leukemia
textual definition: A chronic lymphocytic leukemia that is characterized by over production of B cells (lymphocytes) by the bone marrow where the B cells appear hairy under a microscope.
imported from: doid.owl
has cross-reference: GARD:6560
has cross-reference: ICD10CM:C91.4
has cross-reference: ICD9CM:202.4
has cross-reference: MESH:D007943
has cross-reference: NCI:C7402
has cross-reference: SNOMEDCT_US_2020_03_01:118613001
has cross-reference: UMLS_CUI:C0023443
has_obo_namespace: disease_ontology
id: DOID:285
in subset: NCIthesaurus

hyperthyroxinemia
type: Class
subclass of: thyroid gland disease
textual definition: A thyroid gland disease that is characterized by elevated thyroxine levels in the blood.
imported from: doid.owl
has cross-reference: MESH:D006981
has cross-reference: NCI:C131850
has cross-reference: UMLS_CUI:C0020551
has_obo_namespace: disease_ontology
id: DOID:2855
in subset: NCIthesaurus

euthyroid sick syndrome
type: Class
subclass of: thyroid gland disease
imported from: doid.owl
has cross-reference: ICD10CM:E07.81
has cross-reference: ICD9CM:790.94
has cross-reference: MESH:D005067
has cross-reference: NCI:C113170
has cross-reference: SNOMEDCT_US_2020_03_01:237542005
has cross-reference: UMLS_CUI:C0015190
alternative_term: Euthyroid sick syndrome
alternative_term: Sick-euthyroid syndrome
has_obo_namespace: disease_ontology
id: DOID:2856
in subset: NCIthesaurus

hemoglobinopathy
type: Class
subclass of: congenital hemolytic anemia
imported from: doid.owl
has cross-reference: GARD:12455
has cross-reference: ICD10CM:D58.2
has cross-reference: MESH:D006453
has cross-reference: NCI:C3092
has cross-reference: SNOMEDCT_US_2020_03_01:154794008
has cross-reference: UMLS_CUI:C0019045
alternative_term: hemoglobinopathies
has_obo_namespace: disease_ontology
id: DOID:2860
in subset: NCIthesaurus

glucosephosphate dehydrogenase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
textual definition: A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH).
imported from: doid.owl
has cross-reference: GARD:6520
has cross-reference: MESH:D005955
has cross-reference: NCI:C98933
has cross-reference: SNOMEDCT_US_2020_03_01:124134002
has cross-reference: UMLS_CUI:C2939465
alternative_term: Glucose-6-phosphate dehydrogenase deficiency
alternative_term: deficiency of G-6PD
has_obo_namespace: disease_ontology
id: DOID:2862
in subset: NCIthesaurus

endometrial adenocarcinoma
type: Class
subclass of: endometrial carcinoma
subclass of: adenocarcinoma
textual definition: An endometrial carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has_alternative_id: DOID:5827
has_alternative_id: DOID:6650
has cross-reference: NCI:C6287
has cross-reference: NCI:C6290
has cross-reference: NCI:C7359
has cross-reference: SNOMEDCT_US_2020_03_01:123845008
has cross-reference: SNOMEDCT_US_2020_03_01:762458004
has cross-reference: UMLS_CUI:C0279763
has cross-reference: UMLS_CUI:C1153706
has cross-reference: UMLS_CUI:C1336905
alternative_term: adenocarcinoma of endometrium
alternative_term: adenocarcinoma of the Endometrium
alternative_term: adenocarcinoma of uterus
alternative_term: endometrial adenoacanthoma
alternative_term: endometrial endometrioid adenocarcinoma
alternative_term: endometrial endometrioid adenocarcinoma with squamous differentiation
alternative_term: endometrioid adenoma or carcinoma
alternative_term: endometrioid adenomas and carcinomas
alternative_term: endometrioid carcinoma of Endometrium
has_obo_namespace: disease_ontology
id: DOID:2870
in subset: NCIthesaurus

endometrial carcinoma
type: Class
subclass of: endometrial cancer
subclass of: carcinoma
textual definition: A endometrial cancer that is located_in the tissue lining the uterus.
imported from: doid.owl
has_alternative_id: DOID:3000
has cross-reference: MESH:D016889
has cross-reference: MESH:D018269
has cross-reference: NCI:C3769
has cross-reference: NCI:C7558
has cross-reference: SNOMEDCT_US_2020_03_01:30289006
has cross-reference: SNOMEDCT_US_2020_03_01:93781006
has cross-reference: UMLS_CUI:C0206687
has cross-reference: UMLS_CUI:C0476089
alternative_term: carcinoma of the Endometrium
alternative_term: endometrioid carcinoma
alternative_term: endometrioid carcinoma of female Reproductive system
has_obo_namespace: disease_ontology
id: DOID:2871
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

laryngeal squamous cell carcinoma
type: Class
subclass of: squamous cell carcinoma
subclass of: laryngeal carcinoma
textual definition: A laryngeal carcinoma that has_material_basis_in squamous cells.
imported from: doid.owl
has cross-reference: NCI:C4044
has cross-reference: SNOMEDCT_US_2020_03_01:707358000
has cross-reference: UMLS_CUI:C0280324
alternative_term: Epidermoid carcinoma of the Larynx
alternative_term: squamous cell carcinoma of larynx
has_obo_namespace: disease_ontology
id: DOID:2876
in subset: DO cancer slim
in subset: NCIthesaurus

endometriosis of uterus
type: Class
subclass of: endometriosis
subclass of: uterine disease
textual definition: A uterine disease that is characterized by the presence of endometrial tissue grows outside of the endometrium, such as into the myometrium.
imported from: doid.owl
has cross-reference: ICD10CM:N80.0
has cross-reference: ICD9CM:617.0
has cross-reference: MESH:D062788
has cross-reference: NCI:C6996
has cross-reference: OMIM:600458
has cross-reference: SNOMEDCT_US_2020_03_01:76376003
has cross-reference: UMLS_CUI:C0341858
alternative_term: Endometriosis interna
alternative_term: Endometriosis of myometrium
alternative_term: Endometriosis, myometrium
alternative_term: adenomyosis
alternative_term: uterine Adenomyosis
has_obo_namespace: disease_ontology
id: DOID:288
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

prostatic adenoma
type: Class
subclass of: cell type benign neoplasm
subclass of: male reproductive organ benign neoplasm
subclass of: prostate disease
textual definition: A male reproductive organ benign neoplasm that derives_from glandular epithelial cells and that is located_in the prostate.
imported from: doid.owl
has cross-reference: MESH:D011470
has cross-reference: NCI:C4795
has cross-reference: SNOMEDCT_US_2020_03_01:21173002
has cross-reference: UMLS_CUI:C0520477
alternative_term: adenoma - prostate
alternative_term: adenoma of prostate
alternative_term: benign adenoma of prostate
alternative_term: prostate adenoma
has_obo_namespace: disease_ontology
id: DOID:2883
in subset: NCIthesaurus

retrocochlear disease
type: Class
subclass of: auditory system disease
imported from: doid.owl
has cross-reference: MESH:D012181
has cross-reference: UMLS_CUI:C0035352
has_obo_namespace: disease_ontology
id: DOID:2889

endometriosis
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.
imported from: doid.owl
has cross-reference: EFO:0001065
has cross-reference: ICD10CM:N80
has cross-reference: ICD9CM:617
has cross-reference: MESH:D004715
has cross-reference: NCI:C3014
has cross-reference: SNOMEDCT_US_2020_03_01:11871002
has cross-reference: UMLS_CUI:C0014175
has_obo_namespace: disease_ontology
id: DOID:289
in subset: NCIthesaurus

thyroid adenoma
type: Class
subclass of: endocrine organ benign neoplasm
subclass of: thyroid gland disease
subclass of: adenoma
textual definition: An endocrine organ benign neoplasm that is located_in the thyroid and derives_from glandular epithelial cells.
imported from: doid.owl
has cross-reference: MESH:D013964
has cross-reference: NCI:C3502
has cross-reference: SNOMEDCT_US_2020_03_01:189174004
has cross-reference: UMLS_CUI:C0151468
alternative_term: adenoma of thyroid gland
has_obo_namespace: disease_ontology
id: DOID:2891
in subset: NCIthesaurus

cervix carcinoma
type: Class
subclass of: carcinoma
subclass of: cervical cancer
textual definition: A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C9039
has cross-reference: SNOMEDCT_US_2020_03_01:285432005
has cross-reference: UMLS_CUI:C0302592
alternative_term: cancer of cervix
alternative_term: carcinoma cervix uteri
alternative_term: carcinoma of cervix
alternative_term: carcinoma of the Cervix Uteri
has_obo_namespace: disease_ontology
id: DOID:2893
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Goldenhar syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.
imported from: doid.owl
has cross-reference: GARD:6540
has cross-reference: ICD10CM:Q87.0
has cross-reference: MESH:D006053
has cross-reference: NCI:C84740
has cross-reference: OMIM:164210
has cross-reference: ORDO:374
has cross-reference: SNOMEDCT_US_2020_03_01:46567003
has cross-reference: UMLS_CUI:C0265240
alternative_term: Facio-auriculo-vertebral spectrum
alternative_term: First AND second branchial arch syndrome
alternative_term: First arch syndrome
alternative_term: HEMIFACIAL MICROSOMIA
alternative_term: OAV (oculoauriculovertebral) dysplasia
alternative_term: Otomandibular dysostosis
has_obo_namespace: disease_ontology
id: DOID:2907
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Treacher Collins syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by bilateral and symmetric downslanting palpebral fissures, malar hypoplasia, micrognathia, and external ear abnormalities.
imported from: doid.owl
has cross-reference: GARD:9124
has cross-reference: ICD10CM:Q75.4
has cross-reference: MESH:D008342
has cross-reference: NCI:C75018
has cross-reference: OMIM:PS154500
has cross-reference: SNOMEDCT_US_2020_03_01:205416009
has cross-reference: UMLS_CUI:C0242387
alternative_term: Franceschetti syndrome
alternative_term: Mandibulofacial dysostosis
alternative_term: mandibulofacial dysostosis
has_obo_namespace: disease_ontology
id: DOID:2908
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

acute pancreatitis
type: Class
subclass of: pancreatitis
imported from: doid.owl
has_alternative_id: DOID:2912
has cross-reference: ICD10CM:K85
has cross-reference: ICD9CM:577.0
has cross-reference: MESH:D010195
has cross-reference: NCI:C95437
has cross-reference: SNOMEDCT_US_2020_03_01:39726008
has cross-reference: UMLS_CUI:C0001339
alternative_term: PANCREATITIS NECROTIZING
alternative_term: acute necrotizing pancreatitis
has_obo_namespace: disease_ontology
id: DOID:2913
in subset: NCIthesaurus

immune system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in the immune system.
imported from: doid.owl
has cross-reference: EFO:0000540
has cross-reference: ICD10CM:D89.9
has cross-reference: ICD9CM:279.9
has cross-reference: SNOMEDCT_US_2020_03_01:154782004
has cross-reference: UMLS_CUI:C0041806
has_obo_namespace: disease_ontology
id: DOID:2914
in subset: DO AGR slim
in subset: DO FlyBase slim
in subset: DO GXD slim
in subset: DO MGI slim

hypersensitivity reaction type IV disease
type: Class
subclass of: hypersensitivity reaction disease
textual definition: A hypersensitivity reaction disease that is characterized by a cell-mediated response to antigens, where Th1 helper T cells react with antigens on antigen-presenting cells and cause a delayed type immune response.
imported from: doid.owl
has cross-reference: ICD10CM:C88.9
has cross-reference: MESH:D007160
has cross-reference: SNOMEDCT_US_2020_03_01:127071007
has cross-reference: UMLS_CUI:C0021070
has_obo_namespace: disease_ontology
has_related_synonym: immunoproliferative disease
id: DOID:2916

cryoglobulinemia
type: Class
subclass of: hypersensitivity reaction type IV disease
textual definition: A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.
imported from: doid.owl
has cross-reference: GARD:6217
has cross-reference: ICD10CM:D89.1
has cross-reference: MESH:D003449
has cross-reference: NCI:C26736
has cross-reference: SNOMEDCT_US_2020_03_01:30911005
has cross-reference: UMLS_CUI:C0010403
alternative_term: CRYOGLOBULINEMIA
alternative_term: Cryoimmunoglobulinaemia
has_obo_namespace: disease_ontology
id: DOID:2917
in subset: NCIthesaurus

lacrimal system cancer
type: Class
subclass of: lacrimal apparatus disease
subclass of: ocular cancer
imported from: doid.owl
has cross-reference: NCI:C5102
has cross-reference: SNOMEDCT_US_2020_03_01:416510003
has cross-reference: UMLS_CUI:C1334361
alternative_term: lacrimal system neoplasm
alternative_term: neoplasm of lacrimal system
alternative_term: tumor of the lacrimal system
has_obo_namespace: disease_ontology
id: DOID:292
in subset: NCIthesaurus

membranoproliferative glomerulonephritis
type: Class
subclass of: glomerulonephritis
imported from: doid.owl
has cross-reference: GARD:11982
has cross-reference: MESH:D015432
has cross-reference: NCI:C34644
has cross-reference: OMIM:305800
has cross-reference: SNOMEDCT_US_2020_03_01:80321008
has cross-reference: UMLS_CUI:C0017662
alternative_term: Lobular glomerulonephritis
alternative_term: chronic glomerulonephritis, lobular
has_obo_namespace: disease_ontology
id: DOID:2920
in subset: NCIthesaurus

glomerulonephritis
type: Class
subclass of: nephritis
textual definition: A nephritis that causes inflammation of the glomeruli located_in kidney.
imported from: doid.owl
has cross-reference: GARD:6516
has cross-reference: ICD10CM:N08
has cross-reference: MESH:D005921
has cross-reference: NCI:C26784
has cross-reference: SNOMEDCT_US_2020_03_01:36171008
has cross-reference: UMLS_CUI:C0017658
has_obo_namespace: disease_ontology
id: DOID:2921
in subset: NCIthesaurus

Klippel-Trenaunay syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues.
imported from: doid.owl
has cross-reference: ICD10CM:Q87.2
has cross-reference: MESH:D007715
has cross-reference: NCI:C84801
has cross-reference: OMIM:149000
has cross-reference: SNOMEDCT_US_2020_03_01:59078009
has cross-reference: UMLS_CUI:C0022739
alternative_term: Haemangiectatic hypertrophy
alternative_term: Klippel-Trenaunay-Weber syndrome
alternative_term: angioosteohypertrophy syndrome
has_obo_namespace: disease_ontology
id: DOID:2926
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Newcastle disease
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.
imported from: doid.owl
has cross-reference: MESH:D009521
has cross-reference: NCI:C34849
has cross-reference: SNOMEDCT_US_2020_03_01:258300000
has cross-reference: UMLS_CUI:C0027983
alternative_term: Newcastle's disease
alternative_term: Pseudo-fowlpest
has_obo_namespace: disease_ontology
id: DOID:2929
in subset: NCIthesaurus
in subset: zoonotic infectious disease

Chediak-Higashi syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy; it is that has_material_basis_in mutations in the CHS1 gene.
imported from: doid.owl
has cross-reference: GARD:6035
has cross-reference: ICD10CM:E70.330
has cross-reference: MESH:D002609
has cross-reference: NCI:C2941
has cross-reference: OMIM:214500
has cross-reference: ORDO:167
has cross-reference: SNOMEDCT_US_2020_03_01:111396008
has cross-reference: UMLS_CUI:C0007965
alternative_term: CHS
alternative_term: Chediak - Steinbrinck anomaly
has_obo_namespace: disease_ontology
id: DOID:2935
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

lacrimal gland cancer
type: Class
subclass of: lacrimal system cancer
imported from: doid.owl
has_alternative_id: DOID:291
has cross-reference: ICD9CM:190.2
has cross-reference: NCI:C3563
has cross-reference: NCI:C4360
has cross-reference: SNOMEDCT_US_2020_03_01:127004000
has cross-reference: SNOMEDCT_US_2020_03_01:188271007
has cross-reference: UMLS_CUI:C0153627
has cross-reference: UMLS_CUI:C0339124
alternative_term: malignant neoplasm of lacrimal gland
alternative_term: malignant tumour of lacrimal gland
alternative_term: neoplasm of lacrimal gland
alternative_term: tumor of the lacrimal gland
has_obo_namespace: disease_ontology
id: DOID:294
in subset: NCIthesaurus

bronchiolitis
type: Class
subclass of: bronchial disease
subclass of: lung disease
textual definition: A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen.
imported from: doid.owl
has cross-reference: MESH:D001988
has cross-reference: NCI:C39658
has cross-reference: SNOMEDCT_US_2020_03_01:4120002
has cross-reference: UMLS_CUI:C0006271
has_obo_namespace: disease_ontology
id: DOID:2942
in subset: NCIthesaurus

severe acute respiratory syndrome
type: Class
subclass of: Coronavirus infectious disease
textual definition: A Coronavirus infection that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.
imported from: doid.owl
has cross-reference: GARD:9237
has cross-reference: ICD10CM:J12.81
has cross-reference: ICD9CM:079.82
has cross-reference: MESH:D045169
has cross-reference: NCI:C85064
has cross-reference: SNOMEDCT_US_2020_03_01:398447004
has cross-reference: UMLS_CUI:C1175175
alternative_term: SARS
alternative_term: SARS-CoV infection
has_obo_namespace: disease_ontology
id: DOID:2945
in subset: NCIthesaurus
in subset: zoonotic infectious disease

motion sickness
type: Class
subclass of: inner ear disease
imported from: doid.owl
has cross-reference: ICD10CM:T75.3
has cross-reference: ICD9CM:994.6
has cross-reference: MESH:D009041
has cross-reference: NCI:C34824
has cross-reference: OMIM:158280
has cross-reference: SNOMEDCT_US_2020_03_01:37031009
has cross-reference: UMLS_CUI:C0026603
alternative_term: Travel Sickness
has_obo_namespace: disease_ontology
id: DOID:2951
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

inner ear disease
type: Class
subclass of: auditory system disease
imported from: doid.owl
has cross-reference: ICD10CM:H83.9
has cross-reference: MESH:D007759
has cross-reference: NCI:C128369
has cross-reference: NCI:C27166
has cross-reference: SNOMEDCT_US_2020_03_01:194690003
has cross-reference: SNOMEDCT_US_2020_03_01:20425006
has cross-reference: UMLS_CUI:C0022890
has cross-reference: UMLS_CUI:C0494559
alternative_term: labyrinthine disease
has_obo_namespace: disease_ontology
id: DOID:2952
in subset: NCIthesaurus

hyperimmunoglobulin syndrome
type: Class
subclass of: B cell deficiency
textual definition: A B cell deficiency that is characterized by relative predominance of certain immunoglobulin subtypes and deficiencies of others.
imported from: doid.owl
has cross-reference: NCI:C27579
has cross-reference: UMLS_CUI:C1334069
has_obo_namespace: disease_ontology
id: DOID:2959
in subset: NCIthesaurus

photosensitive trichothiodystrophy
type: Class
subclass of: trichothiodystrophy
textual definition: A trichothiodystrophy characterized by skin that is extremely sensitive to ultraviolet (UV) rays from sunlight.
imported from: doid.owl
has cross-reference: MESH:D054463
has cross-reference: NCI:C4924
has cross-reference: OMIM:PS601675
has cross-reference: SNOMEDCT_US_2020_03_01:723551003
alternative_term: IBIDS syndrome
alternative_term: TTD-P
alternative_term: Tay syndrome
alternative_term: sulfur-deficient brittle hair syndrome
alternative_term: trichothiodystrophy with congenital ichthyosis
has_obo_namespace: disease_ontology
id: DOID:2960
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Cockayne syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome that has_material_basis_in rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.
imported from: doid.owl
has cross-reference: GARD:6122
has cross-reference: ICD10CM:Q87.19
has cross-reference: MESH:D003057
has cross-reference: NCI:C9460
has cross-reference: OMIM:133540
has cross-reference: OMIM:216400
has cross-reference: ORDO:191
has cross-reference: ORDO:90321
has cross-reference: ORDO:90322
has cross-reference: ORDO:90324
has cross-reference: SNOMEDCT_US_2020_03_01:205832003
has cross-reference: UMLS_CUI:C0009207
alternative_term: Neill-Dingwall syndrome
has_obo_namespace: disease_ontology
has_related_synonym: Cockayne's syndrome
id: DOID:2962
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

bursitis
type: Class
subclass of: arthropathy
imported from: doid.owl
has cross-reference: ICD10CM:M71.9
has cross-reference: MESH:D002062
has cross-reference: NCI:C94407
has cross-reference: SNOMEDCT_US_2020_03_01:156677003
has cross-reference: UMLS_CUI:C0006444
has_obo_namespace: disease_ontology
id: DOID:2965
in subset: NCIthesaurus

pleomorphic adenoma carcinoma
type: Class
subclass of: DOID 8850
imported from: doid.owl
has cross-reference: NCI:C4397
has cross-reference: SNOMEDCT_US_2020_03_01:17264009
has cross-reference: UMLS_CUI:C0344460
alternative_term: carcinoma ex pleomorphic adenoma
alternative_term: carcinoma in pleomorphic adenoma
has_obo_namespace: disease_ontology
id: DOID:297
in subset: NCIthesaurus

cystic kidney disease
type: Class
subclass of: kidney disease
imported from: doid.owl
has cross-reference: MESH:D052177
has cross-reference: UMLS_CUI:C0022679
alternative_term: renal Cyst
has_obo_namespace: disease_ontology
id: DOID:2975

primary hyperoxaluria
type: Class
subclass of: carbohydrate metabolic disorder
textual definition: A carbohydrate metabolic disorder characterized by impaired glyoxylate metabolism resulting in accumulation of oxalate throughout the body typically manifesting as kidney and bladder stones.
imported from: doid.owl
has_alternative_id: DOID:2979
has cross-reference: ICD10CM:E72.53
has cross-reference: ICD10CM:R82.992
has cross-reference: MESH:D006959
has cross-reference: MESH:D006960
has cross-reference: NCI:C123158
has cross-reference: OMIM:PS259900
has cross-reference: ORDO:416
has cross-reference: SNOMEDCT_US_2020_03_01:190766003
has cross-reference: SNOMEDCT_US_2020_03_01:367621000119107
has cross-reference: UMLS_CUI:C0020500
has cross-reference: UMLS_CUI:C0020501
has_obo_namespace: disease_ontology
id: DOID:2977
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

carbohydrate metabolic disorder
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates.
imported from: doid.owl
has_alternative_id: DOID:9434
has cross-reference: MESH:D002239
has cross-reference: UMLS_CUI:C0007001
alternative_term: disorder of carbohydrate transport and metabolism
alternative_term: inborn carbohydrate metabolism disorder
alternative_term: inborn errors of carbohydrate metabolism
has_obo_namespace: disease_ontology
id: DOID:2978

perinephritis
type: Class
subclass of: kidney disease
imported from: doid.owl
has cross-reference: MESH:D010501
has cross-reference: SNOMEDCT_US_2020_03_01:111404004
has cross-reference: UMLS_CUI:C0031065
has_obo_namespace: disease_ontology
id: DOID:2982

anuria
type: Class
subclass of: kidney disease
imported from: doid.owl
has cross-reference: MESH:D001002
has cross-reference: NCI:C114699
has cross-reference: SNOMEDCT_US_2020_03_01:139460001
has cross-reference: UMLS_CUI:C0003460
alternative_term: Suppression of urinary secretion
has_obo_namespace: disease_ontology
id: DOID:2983
in subset: NCIthesaurus

IgA glomerulonephritis
type: Class
subclass of: glomerulonephritis
textual definition: A glomerulonephritis characterized by build up of IgA antibody in the glomerulus.
imported from: doid.owl
has cross-reference: EFO:0004194
has cross-reference: GARD:863
has cross-reference: MESH:D005922
has cross-reference: NCI:C34643
has cross-reference: OMIM:161950
has cross-reference: SNOMEDCT_US_2020_03_01:236407003
has cross-reference: UMLS_CUI:C0017661
alternative_term: Berger's IgA or IgG nephropathy
alternative_term: Focal Glomerulonephritis
alternative_term: IGA glomerulonephritis
alternative_term: IgA nephropathy
alternative_term: primary IgA nephropathy
alternative_term: segmental glomerulonephritis
has_obo_namespace: disease_ontology
id: DOID:2986
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

familial Mediterranean fever
type: Class
subclass of: autosomal genetic disease
subclass of: autoimmune disease
textual definition: An autoimmune disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has_material_basis_in mutations in the MEFV gene, which encodes the protein pyrin.
imported from: doid.owl
has cross-reference: GARD:6421
has cross-reference: ICD10CM:M04.1
has cross-reference: ICD9CM:277.31
has cross-reference: MESH:D010505
has cross-reference: NCI:C84707
has cross-reference: OMIM:134610
has cross-reference: OMIM:249100
has cross-reference: ORDO:342
has cross-reference: SNOMEDCT_US_2020_03_01:12579009
has cross-reference: UMLS_CUI:C0031069
alternative_term: benign paroxysmal peritonitis
has_obo_namespace: disease_ontology
id: DOID:2987
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

antiphospholipid syndrome
type: Class
subclass of: autoimmune disease of cardiovascular system
textual definition: An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).
imported from: doid.owl
has cross-reference: GARD:5824
has cross-reference: ICD10CM:D68.61
has cross-reference: MESH:D016736
has cross-reference: NCI:C61283
has cross-reference: OMIM:107320
has cross-reference: SNOMEDCT_US_2020_03_01:201450008
has cross-reference: UMLS_CUI:C0085278
alternative_term: Antiphospholipid syndrome
alternative_term: antiphospholipid antibody syndrome
has_obo_namespace: disease_ontology
id: DOID:2988
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

adenocarcinoma
type: Class
subclass of: carcinoma
textual definition: A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.
imported from: doid.owl
has cross-reference: MESH:D000230
has cross-reference: NCI:C2852
has cross-reference: SNOMEDCT_US_2020_03_01:443961001
has cross-reference: UMLS_CUI:C0001418
has_obo_namespace: disease_ontology
id: DOID:299
in subset: NCIthesaurus

germ cell cancer
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells.
imported from: doid.owl
has_alternative_id: DOID:2157
has cross-reference: MESH:D009373
has cross-reference: NCI:C3708
has cross-reference: SNOMEDCT_US_2020_03_01:302853003
has cross-reference: UMLS_CUI:C0205851
alternative_term: malignant tumor of the germ cell
has_obo_namespace: disease_ontology
has_related_synonym: germ cell neoplasm
has_related_synonym: germ cell tumour
id: DOID:2994
in subset: NCIthesaurus

Sertoli-Leydig cell tumor
type: Class
subclass of: sex cord-gonadal stromal tumor
textual definition: A sex cord-gonadal stromal tumor characterized by variable proportions of Sertoli cells, Leydig cells, primitive gonadal stroma and/or heterologous elements located_in the ovaries and testicles.
imported from: doid.owl
has_alternative_id: DOID:0050618
has cross-reference: GARD:9967
has cross-reference: MESH:D018310
has cross-reference: SNOMEDCT_US_2020_03_01:34110004
has cross-reference: UMLS_CUI:C0206723
has_obo_namespace: disease_ontology
id: DOID:2997

testicular cancer
type: Class
subclass of: testicular disease
subclass of: male reproductive organ cancer
textual definition: A male reproductive system cancer that is located_in the testicles.
imported from: doid.owl
has_alternative_id: DOID:12231
has_alternative_id: DOID:5554
has cross-reference: GARD:7746
has cross-reference: ICD10CM:C62
has cross-reference: ICD9CM:186
has cross-reference: MESH:D013736
has cross-reference: NCI:C3404
has cross-reference: NCI:C5053
has cross-reference: NCI:C7251
has cross-reference: SNOMEDCT_US_2020_03_01:126900000
has cross-reference: SNOMEDCT_US_2020_03_01:94087009
has cross-reference: UMLS_CUI:C0039590
has cross-reference: UMLS_CUI:C0153594
has cross-reference: UMLS_CUI:C1333010
alternative_term: childhood neoplasm of the testis
alternative_term: neoplasm of testis
alternative_term: pediatric testicular neoplasm
alternative_term: testicular tumor
alternative_term: testis cancer
alternative_term: testis neoplasm
has_obo_namespace: disease_ontology
id: DOID:2998
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: OMIM mapping confirmed by DO. [SN].

granulosa cell tumor
type: Class
subclass of: sex cord-gonadal stromal tumor
textual definition: A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma.
imported from: doid.owl
has_alternative_id: DOID:5333
has cross-reference: MESH:D006106
has cross-reference: NCI:C3070
has cross-reference: NCI:C4205
has cross-reference: SNOMEDCT_US_2020_03_01:18861007
has cross-reference: SNOMEDCT_US_2020_03_01:46585005
has cross-reference: UMLS_CUI:C0018206
has cross-reference: UMLS_CUI:C0334401
alternative_term: Granulosa cell neoplasm
alternative_term: Granulosa cell tumor, adult type
alternative_term: Granulosa cell tumour, sarcomatoid
alternative_term: malignant granulosa cell neoplasm
has_obo_namespace: disease_ontology
id: DOID:2999
in subset: NCIthesaurus

breast myoepithelial neoplasm
type: Class
subclass of: breast cancer
textual definition: A breast cancer that arises from myoepithelial cells, which are a normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane.
imported from: doid.owl
has cross-reference: NCI:C40389
has cross-reference: UMLS_CUI:C1511319
has_obo_namespace: disease_ontology
id: DOID:3004
in subset: NCIthesaurus

lobular neoplasia
type: Class
subclass of: DOID 8791
textual definition: A breast carcinoma in situ that is characterized by abnormal cells are found in the lobules (glands that make milk) of the breast.
imported from: doid.owl
has cross-reference: NCI:C27939
has cross-reference: UMLS_CUI:C0861352
alternative_term: Lobular Intraepithelial Neoplasia
alternative_term: lobular carcinoma in situ
has_obo_namespace: disease_ontology
id: DOID:3010
in subset: NCIthesaurus

Li-Fraumeni syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome characterized by autosomal dominant inheritance of increased risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata.
imported from: doid.owl
has cross-reference: GARD:6902
has cross-reference: MESH:D016864
has cross-reference: NCI:C3476
has cross-reference: OMIM:PS151623
has cross-reference: ORDO:524
has cross-reference: SNOMEDCT_US_2020_03_01:428850001
has cross-reference: UMLS_CUI:C0085390
alternative_term: Li-Fraumeni Familiar cancer Susceptibility syndrome
alternative_term: SBLA syndrome
alternative_term: sarcoma, breast, leukaemia and adrenal gland syndrome
has_obo_namespace: disease_ontology
id: DOID:3012
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

intraductal breast benign neoplasm
type: Class
subclass of: breast benign neoplasm
textual definition: A breast benign neoplasm that is located_in the breast ducts.
imported from: doid.owl
has cross-reference: NCI:C36083
has cross-reference: UMLS_CUI:C0948967
has_obo_namespace: disease_ontology
id: DOID:3013
in subset: NCIthesaurus

breast malignant phyllodes tumor
type: Class
subclass of: breast cancer
textual definition: A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises_from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).
imported from: doid.owl
has_alternative_id: DOID:1632
has_alternative_id: DOID:3018
has cross-reference: MESH:D003557
has cross-reference: NCI:C4275
has cross-reference: NCI:C4504
has cross-reference: NCI:C7575
has cross-reference: SNOMEDCT_US_2020_03_01:254844000
has cross-reference: SNOMEDCT_US_2020_03_01:712989008
has cross-reference: SNOMEDCT_US_2020_03_01:87913009
has cross-reference: UMLS_CUI:C0238031
has cross-reference: UMLS_CUI:C0346154
has cross-reference: UMLS_CUI:C0600066
alternative_term: Phyllodes breast neoplasm
alternative_term: Phyllodes tumor, malignant
alternative_term: breast malignant phyllodes tumour
alternative_term: malignant Mammary Phyllodes tumor
alternative_term: malignant Mammary Phyllodes tumour
alternative_term: malignant Phyllodes neoplasm
alternative_term: malignant cystosarcoma phyllodes
alternative_term: malignant phyllodes tumor
alternative_term: malignant phyllodes tumor of breast
alternative_term: malignant phyllodes tumour
alternative_term: malignant phyllodes tumour of breast
alternative_term: phyllodes breast tumor
alternative_term: phyllodes breast tumour
has_obo_namespace: disease_ontology
id: DOID:3016
in subset: NCIthesaurus

breast sarcoma
type: Class
subclass of: breast cancer
textual definition: A breast cancer that has_material_basis_in abnormally proliferating cells derives_from mesenchymal cells.
imported from: doid.owl
has cross-reference: NCI:C4670
has cross-reference: SNOMEDCT_US_2020_03_01:278050001
has cross-reference: UMLS_CUI:C0349667
alternative_term: sarcoma of breast
has_obo_namespace: disease_ontology
id: DOID:3017
in subset: NCIthesaurus

substance abuse
type: Class
subclass of: substance-related disorder
textual definition: A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.
imported from: doid.owl
has cross-reference: MESH:D019966
has cross-reference: NCI:C16522
has cross-reference: SNOMEDCT_US_2020_03_01:26416006
has cross-reference: UMLS_CUI:C0013146
has_obo_namespace: disease_ontology
id: DOID:302
in subset: NCIthesaurus

acinar cell carcinoma
type: Class
subclass of: carcinoma
textual definition: A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from spindle cells and/or derives_from giant cells.
imported from: doid.owl
has cross-reference: GARD:8568
has cross-reference: MESH:D018267
has cross-reference: NCI:C3768
has cross-reference: SNOMEDCT_US_2020_03_01:45410002
has cross-reference: UMLS_CUI:C0206685
alternative_term: acinic cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:3025
in subset: NCIthesaurus

substance-related disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning.
imported from: doid.owl
has cross-reference: MESH:D019966
has cross-reference: NCI:C92203
has cross-reference: UMLS_CUI:C0236969
has_obo_namespace: disease_ontology
id: DOID:303
in subset: NCIthesaurus

mucinous adenocarcinoma
type: Class
subclass of: adenocarcinoma
textual definition: An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin.
imported from: doid.owl
has_alternative_id: DOID:4532
has cross-reference: MESH:D002288
has cross-reference: NCI:C26712
has cross-reference: NCI:C27379
has cross-reference: SNOMEDCT_US_2020_03_01:72495009
has cross-reference: SNOMEDCT_US_2020_03_01:900006
has cross-reference: UMLS_CUI:C0007130
has cross-reference: UMLS_CUI:C0334368
alternative_term: Mucin-Secreting adenocarcinoma
alternative_term: Mucin-Secreting carcinoma
alternative_term: Mucin-producing adenocarcinoma
alternative_term: Mucous carcinoma
alternative_term: Pseudomyxoma peritonei with unknown primary site
alternative_term: mucin-producing adenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:3030
in subset: NCIthesaurus

allergic contact dermatitis
type: Class
subclass of: allergic disease
subclass of: contact dermatitis
textual definition: A contact dermatitis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.
imported from: doid.owl
has cross-reference: ICD10CM:L23
has cross-reference: MESH:D017449
has cross-reference: NCI:C26998
has cross-reference: SNOMEDCT_US_2020_03_01:200841005
has cross-reference: UMLS_CUI:C0162820
has_obo_namespace: disease_ontology
id: DOID:3042
in subset: NCIthesaurus

food allergy
type: Class
subclass of: gastrointestinal allergy
textual definition: A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system.
imported from: doid.owl
has cross-reference: MESH:D005512
has cross-reference: SNOMEDCT_US_2020_03_01:213018006
has cross-reference: UMLS_CUI:C0016470
alternative_term: food hypersensitivity
has_obo_namespace: disease_ontology
id: DOID:3044
in subset: DO IEDB slim

Churg-Strauss syndrome
type: Class
subclass of: DOID 865
textual definition: A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding.
imported from: doid.owl
has cross-reference: ICD10CM:M30.1
has cross-reference: MESH:D015267
has cross-reference: NCI:C34481
has cross-reference: SNOMEDCT_US_2020_03_01:82275008
has cross-reference: UMLS_CUI:C0008728
alternative_term: Allergic Granulomatous Angiitis
alternative_term: Allergic granulomatosis angiitis
alternative_term: Churg-Strauss vasculitis
has_obo_namespace: disease_ontology
id: DOID:3049
in subset: NCIthesaurus

carcinoma
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has_alternative_id: DOID:2428
has_alternative_id: DOID:6570
has cross-reference: MESH:D002277
has cross-reference: MESH:D009375
has cross-reference: NCI:C2916
has cross-reference: NCI:C3709
has cross-reference: SNOMEDCT_US_2020_03_01:188083002
has cross-reference: SNOMEDCT_US_2020_03_01:269513004
has cross-reference: SNOMEDCT_US_2020_03_01:71298006
has cross-reference: UMLS_CUI:C0007097
has cross-reference: UMLS_CUI:C0553707
has cross-reference: UMLS_CUI:C1368683
alternative_term: epithelial cancer
alternative_term: epithelioma
alternative_term: malignant Epithelioma
has_obo_namespace: disease_ontology
id: DOID:305
in subset: DO FlyBase slim
in subset: DO cancer slim
in subset: NCIthesaurus

paratyphoid fever
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.
imported from: doid.owl
has_alternative_id: DOID:13324
has_alternative_id: DOID:13325
has_alternative_id: DOID:3053
has cross-reference: ICD10CM:A01.1
has cross-reference: ICD10CM:A01.2
has cross-reference: ICD10CM:A01.3
has cross-reference: ICD10CM:A01.4
has cross-reference: ICD9CM:002.1
has cross-reference: ICD9CM:002.2
has cross-reference: ICD9CM:002.3
has cross-reference: ICD9CM:002.9
has cross-reference: MESH:D010284
has cross-reference: NCI:C34894
has cross-reference: NCI:C34895
has cross-reference: NCI:C34896
has cross-reference: NCI:C34897
has cross-reference: SNOMEDCT_US_2020_03_01:51254007
has cross-reference: SNOMEDCT_US_2020_03_01:71085009
has cross-reference: SNOMEDCT_US_2020_03_01:76623002
has cross-reference: SNOMEDCT_US_2020_03_01:85904008
has cross-reference: UMLS_CUI:C0030528
has cross-reference: UMLS_CUI:C0343375
has cross-reference: UMLS_CUI:C0343376
has cross-reference: UMLS_CUI:C0343377
alternative_term: Paratyphoid
alternative_term: Paratyphoid A fever
alternative_term: Paratyphoid B fever
alternative_term: Paratyphoid C fever
alternative_term: Paratyphoid Fever A
alternative_term: Paratyphoid Fever B
alternative_term: Paratyphoid Fever C
alternative_term: Paratyphoid fever A
alternative_term: Paratyphoid fever B
alternative_term: Paratyphoid fever C
alternative_term: paratyphoid a
alternative_term: paratyphoid b
alternative_term: paratyphoid c
has_obo_namespace: disease_ontology
id: DOID:3055
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease

glioblastoma
type: Class
subclass of: astrocytoma
textual definition: An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.
imported from: doid.owl
has_alternative_id: DOID:3075
has_alternative_id: DOID:3080
has cross-reference: GARD:2491
has cross-reference: MESH:D005909
has cross-reference: NCI:C3058
has cross-reference: NCI:C39750
has cross-reference: NCI:C9094
has cross-reference: SNOMEDCT_US_2020_03_01:63634009
has cross-reference: UMLS_CUI:C0017636
has cross-reference: UMLS_CUI:C0278878
has cross-reference: UMLS_CUI:C1514422
alternative_term: GBM
alternative_term: adult glioblastoma multiforme
alternative_term: glioblastoma multiforme
alternative_term: grade IV adult Astrocytic tumor
alternative_term: primary glioblastoma multiforme
alternative_term: spongioblastoma multiforme
has_obo_namespace: disease_ontology
id: DOID:3068
in subset: DO cancer slim
in subset: NCIthesaurus

astrocytoma
type: Class
subclass of: malignant glioma
textual definition: A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord.
imported from: doid.owl
has_alternative_id: DOID:4861
has cross-reference: ICDO:M9400/3
has cross-reference: MESH:D001254
has cross-reference: NCI:C4951
has cross-reference: NCI:C60781
has cross-reference: SNOMEDCT_US_2020_03_01:189914005
has cross-reference: SNOMEDCT_US_2020_03_01:99131000119108
has cross-reference: UMLS_CUI:C0004114
has cross-reference: UMLS_CUI:C0750935
alternative_term: Astrocytic tumor
alternative_term: Astrocytoma, NOS
alternative_term: astrocytoma of Cerebrum
alternative_term: astrocytoma of brain
alternative_term: astroglioma
alternative_term: cerebral astrocytoma
has_obo_namespace: disease_ontology
id: DOID:3069
in subset: NCIthesaurus

malignant glioma
type: Class
subclass of: cell type cancer
subclass of: spinal disease
subclass of: brain cancer
subclass of: bone cancer
textual definition: A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.
imported from: doid.owl
has_alternative_id: DOID:2627
has cross-reference: ICDO:M9380/3
has cross-reference: KEGG:05214
has cross-reference: MESH:D005910
has cross-reference: NCI:C4822
has cross-reference: OMIM:PS137800
has cross-reference: ORDO:182067
has cross-reference: SNOMEDCT_US_2020_03_01:393564001
has cross-reference: SNOMEDCT_US_2020_03_01:74532006
has cross-reference: UMLS_CUI:C0017638
has cross-reference: UMLS_CUI:C0555198
alternative_term: Neuroglial tumor
alternative_term: glial cell tumor
alternative_term: glioma, malignant
alternative_term: malignant Neuroglial tumor
has_obo_namespace: disease_ontology
id: DOID:3070
in subset: DO cancer slim
in subset: DO rare slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

gliosarcoma
type: Class
subclass of: glioblastoma
textual definition: A gliomablastoma that is characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation.
imported from: doid.owl
has cross-reference: GARD:5653
has cross-reference: MESH:D018316
has cross-reference: NCI:C3796
has cross-reference: SNOMEDCT_US_2020_03_01:35262004
has cross-reference: UMLS_CUI:C0206726
alternative_term: Glioblastoma with sarcomatous component
has_obo_namespace: disease_ontology
id: DOID:3071
in subset: NCIthesaurus

early myoclonic encephalopathy
type: Class
subclass of: neonatal period electroclinical syndrome
imported from: doid.owl
has cross-reference: MESH:D004831
has cross-reference: UMLS_CUI:C0014550
alternative_term: Epileptic seizures - myoclonic
alternative_term: Epileptic seizures, myoclonic
alternative_term: Myoclonic seizure
alternative_term: Myoclonic seizure disorder
alternative_term: myoclonia epileptica
alternative_term: myoclonic epilepsy
has_obo_namespace: disease_ontology
id: DOID:308

cystic lymphangioma
type: Class
subclass of: lymphangioma
imported from: doid.owl
has cross-reference: GARD:6234
has cross-reference: MESH:D018191
has cross-reference: NCI:C3724
has cross-reference: OMIM:257350
has cross-reference: SNOMEDCT_US_2020_03_01:40225001
has cross-reference: UMLS_CUI:C0206620
alternative_term: cystic Hygroma
has_obo_namespace: disease_ontology
id: DOID:3081
in subset: NCIthesaurus

interstitial lung disease
type: Class
subclass of: connective tissue disease
subclass of: lung disease
textual definition: A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough.
imported from: doid.owl
has cross-reference: GARD:13336
has cross-reference: ICD10CM:J84.9
has cross-reference: MESH:D017563
has cross-reference: SNOMEDCT_US_2020_03_01:64667001
has cross-reference: UMLS_CUI:C0206062
alternative_term: ILD
has_obo_namespace: disease_ontology
id: DOID:3082

chronic obstructive pulmonary disease
type: Class
subclass of: obstructive lung disease
textual definition: An obstructive lung disease that is characterized by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease.
imported from: doid.owl
has_alternative_id: DOID:11500
has_alternative_id: DOID:6144
has cross-reference: EFO:0000341
has cross-reference: ICD10CM:J44.9
has cross-reference: MESH:D029424
has cross-reference: NCI:C3199
has cross-reference: OMIM:606963
has cross-reference: SNOMEDCT_US_2020_03_01:13645005
has cross-reference: UMLS_CUI:C0024117
alternative_term: COLD
alternative_term: COPD
alternative_term: chronic obstructive airway disease
alternative_term: chronic obstructive lung disease
has_obo_namespace: disease_ontology
id: DOID:3083
in subset: NCIthesaurus

gingival overgrowth
type: Class
subclass of: gingival disease
imported from: doid.owl
has cross-reference: ICD10CM:K06.1
has cross-reference: MESH:D019214
has cross-reference: SNOMEDCT_US_2020_03_01:54711002
has cross-reference: UMLS_CUI:C0376480
alternative_term: Gingival enlargement
has_obo_namespace: disease_ontology
id: DOID:3086

gingivitis
type: Class
subclass of: gingival disease
imported from: doid.owl
has_alternative_id: DOID:10422
has_alternative_id: DOID:10424
has cross-reference: ICD10CM:K05.0
has cross-reference: ICD10CM:K05.1
has cross-reference: ICD10CM:K05.10
has cross-reference: ICD9CM:523.0
has cross-reference: ICD9CM:523.1
has cross-reference: MESH:D005891
has cross-reference: NCI:C34474
has cross-reference: NCI:C34636
has cross-reference: SNOMEDCT_US_2020_03_01:155643004
has cross-reference: SNOMEDCT_US_2020_03_01:196355002
has cross-reference: SNOMEDCT_US_2020_03_01:266490003
has cross-reference: UMLS_CUI:C0008684
has cross-reference: UMLS_CUI:C0017574
has cross-reference: UMLS_CUI:C0155937
alternative_term: acute gingivitis
alternative_term: chronic gingivitis
has_obo_namespace: disease_ontology
id: DOID:3087
in subset: NCIthesaurus

nervous system cancer
type: Class
subclass of: organ system cancer
subclass of: DOID 863
textual definition: An organ system cancer located_in the nervous system that affects the central or peripheral nervous system.
imported from: doid.owl
has_alternative_id: DOID:1193
has_alternative_id: DOID:3195
has_alternative_id: DOID:4695
has cross-reference: ICD9CM:192.9
has cross-reference: MESH:D009380
has cross-reference: NCI:C35562
has cross-reference: SNOMEDCT_US_2020_03_01:188306000
has cross-reference: UMLS_CUI:C0027665
has cross-reference: UMLS_CUI:C0153643
has cross-reference: UMLS_CUI:C1334956
alternative_term: malignant neoplasm of nervous system
alternative_term: neoplasm of nervous system
alternative_term: nervous system neoplasm
alternative_term: neural neoplasm
alternative_term: neural tumor
alternative_term: tumor of the nervous system
has_obo_namespace: disease_ontology
id: DOID:3093
in subset: NCIthesaurus

germ cell and embryonal cancer
type: Class
subclass of: sarcoma
subclass of: germ cell cancer
textual definition: A germ cell cancer that is derives_from a mixture of germs cells and embryonal cells.
imported from: doid.owl
has cross-reference: MESH:D009373
has cross-reference: UMLS_CUI:C0027658
has_obo_namespace: disease_ontology
has_related_synonym: germ cell and embryonal neoplasm
id: DOID:3095

thoracic outlet syndrome
type: Class
subclass of: vascular disease
textual definition: A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles.
imported from: doid.owl
has cross-reference: GARD:7759
has cross-reference: ICD10CM:G54.0
has cross-reference: MESH:D013901
has cross-reference: NCI:C85188
has cross-reference: SNOMEDCT_US_2020_03_01:2040007
has cross-reference: UMLS_CUI:C0039984
alternative_term: TOS - Thoracic outlet syndrome
has_obo_namespace: disease_ontology
id: DOID:3103
in subset: NCIthesaurus

ascaridiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.
imported from: doid.owl
has cross-reference: MESH:D001198
has cross-reference: SNOMEDCT_US_2020_03_01:2435008
has cross-reference: UMLS_CUI:C0003952
has_obo_namespace: disease_ontology
id: DOID:3108

cystadenocarcinoma
type: Class
subclass of: malignant cystadenoma
textual definition: An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed.
imported from: doid.owl
has cross-reference: MESH:D003536
has cross-reference: NCI:C2971
has cross-reference: SNOMEDCT_US_2020_03_01:21008007
has cross-reference: UMLS_CUI:C0010631
has_obo_namespace: disease_ontology
id: DOID:3111
in subset: NCIthesaurus

papillary adenocarcinoma
type: Class
subclass of: adenocarcinoma
textual definition: An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.
imported from: doid.owl
has_alternative_id: DOID:5596
has cross-reference: MESH:D000231
has cross-reference: NCI:C2853
has cross-reference: SNOMEDCT_US_2020_03_01:4797003
has cross-reference: UMLS_CUI:C0001420
alternative_term: Infiltrating and papillary adenocarcinoma
alternative_term: Papillary adenocarcinoma
alternative_term: infiltrating papillary adenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:3112
in subset: NCIthesaurus

serous cystadenocarcinoma
type: Class
subclass of: cystadenocarcinoma
textual definition: A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue forming serous lesions.
imported from: doid.owl
has cross-reference: MESH:D018284
has cross-reference: NCI:C3778
has cross-reference: SNOMEDCT_US_2020_03_01:90725004
has cross-reference: UMLS_CUI:C0206701
alternative_term: serous adenocarcinoma
alternative_term: serous carcinoma
has_obo_namespace: disease_ontology
id: DOID:3114
in subset: NCIthesaurus

kidney benign neoplasm
type: Class
subclass of: lipoma
subclass of: kidney disease
subclass of: urinary system benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C7514
has cross-reference: UMLS_CUI:C1334323
alternative_term: renal and ureteral tumor
has_obo_namespace: disease_ontology
id: DOID:3116
in subset: NCIthesaurus

hepatobiliary benign neoplasm
type: Class
subclass of: gastrointestinal system benign neoplasm
textual definition: A gastrointestinal system benign neoplasm located_in the hepatobiliary system.
imported from: doid.owl
has cross-reference: NCI:C8614
has cross-reference: UMLS_CUI:C0854196
alternative_term: hepatobiliary tumors
has_obo_namespace: disease_ontology
id: DOID:3117
in subset: NCIthesaurus

hepatobiliary disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the liver and/or biliary tract.
imported from: doid.owl
has cross-reference: MESH:D004066
has cross-reference: NCI:C3959
has cross-reference: UMLS_CUI:C0267792
alternative_term: liver and biliary tract disease
has_obo_namespace: disease_ontology
id: DOID:3118
in subset: NCIthesaurus

gastrointestinal system cancer
type: Class
subclass of: organ system cancer
subclass of: gastrointestinal system disease
textual definition: An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.
imported from: doid.owl
has_alternative_id: DOID:4945
has_alternative_id: DOID:8377
has cross-reference: ICD10CM:C26.9
has cross-reference: ICD9CM:239.0
has cross-reference: MESH:D004067
has cross-reference: MESH:D005770
has cross-reference: NCI:C3052
has cross-reference: NCI:C4890
has cross-reference: SNOMEDCT_US_2020_03_01:128348002
has cross-reference: SNOMEDCT_US_2020_03_01:276806006
has cross-reference: SNOMEDCT_US_2020_03_01:428905002
has cross-reference: UMLS_CUI:C0012243
has cross-reference: UMLS_CUI:C0017185
has cross-reference: UMLS_CUI:C0685938
alternative_term: GI tumor
alternative_term: digestive system cancer
alternative_term: gastrointestinal tract cancer
has_obo_namespace: disease_ontology
id: DOID:3119
in subset: DO FlyBase slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

gallbladder cancer
type: Class
subclass of: gallbladder disease
subclass of: biliary tract cancer
textual definition: A biliary tract cancer that is located_in the gallbladder.
imported from: doid.owl
has_alternative_id: DOID:8090
has_alternative_id: DOID:8157
has cross-reference: GARD:9328
has cross-reference: ICD10CM:C23
has cross-reference: ICD9CM:156.0
has cross-reference: MESH:D005706
has cross-reference: NCI:C3048
has cross-reference: NCI:C35676
has cross-reference: NCI:C7481
has cross-reference: SNOMEDCT_US_2020_03_01:126854002
has cross-reference: SNOMEDCT_US_2020_03_01:93810008
has cross-reference: UMLS_CUI:C0016978
has cross-reference: UMLS_CUI:C0153452
has cross-reference: UMLS_CUI:C0278806
alternative_term: gallbladder Ca
alternative_term: gallbladder neoplasm
alternative_term: localized malignant gallbladder neoplasm
alternative_term: malignant neoplasm of gallbladder
alternative_term: malignant tumor of the gallbladder
alternative_term: malignant tumour of gallbladder
alternative_term: tumor of the gallbladder
has_obo_namespace: disease_ontology
id: DOID:3121
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

gastric outlet obstruction
type: Class
subclass of: stomach disease
imported from: doid.owl
has cross-reference: MESH:D017219
has cross-reference: SNOMEDCT_US_2020_03_01:196759006
has cross-reference: UMLS_CUI:C0162651
alternative_term: gastric outflow obstruction
has_obo_namespace: disease_ontology
id: DOID:3122

multiple endocrine neoplasia
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by tumors in at least two endocrine glands.
imported from: doid.owl
alternative_term: Multiple endocrine adenomatosis
has_obo_namespace: disease_ontology
id: DOID:3125

proctitis
type: Class
subclass of: rectal disease
textual definition: A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding.
imported from: doid.owl
has cross-reference: ICD10CM:K62.89
has cross-reference: MESH:D011349
has cross-reference: NCI:C38011
has cross-reference: SNOMEDCT_US_2020_03_01:266534007
has cross-reference: UMLS_CUI:C0033246
has_narrow_synonym: ulcerative proctitis
has_obo_namespace: disease_ontology
id: DOID:3127
in subset: NCIthesaurus

anus disease
type: Class
subclass of: rectal disease
imported from: doid.owl
has_alternative_id: DOID:11479
has_alternative_id: DOID:11993
has cross-reference: MESH:D001004
has cross-reference: NCI:C26695
has cross-reference: SNOMEDCT_US_2020_03_01:32110003
has cross-reference: UMLS_CUI:C0003462
alternative_term: Nontraumatic tear of anus
alternative_term: Solitary anal ulcer
alternative_term: Ulcer of anus
alternative_term: anal disease
alternative_term: anal fissure
alternative_term: anal fissure and fistula
alternative_term: anal ulcer
alternative_term: fissure in ano
has_obo_namespace: disease_ontology
id: DOID:3128
in subset: NCIthesaurus

porphyria cutanea tarda
type: Class
subclass of: acute porphyria
textual definition: An acute porphyria characterized by painful, blistering skin lesions that develop on sun-exposed skin.
imported from: doid.owl
has cross-reference: GARD:7433
has cross-reference: ICD10CM:E80.1
has cross-reference: MESH:D017119
has cross-reference: NCI:C27725
has cross-reference: OMIM:176090
has cross-reference: OMIM:176100
has cross-reference: ORDO:101330
has cross-reference: SNOMEDCT_US_2020_03_01:61860000
has cross-reference: UMLS_CUI:C0162566
has_obo_namespace: disease_ontology
id: DOID:3132
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

acute porphyria
type: Class
subclass of: porphyria
textual definition: A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis.
imported from: doid.owl
has cross-reference: MESH:D017094
has cross-reference: OMIM:612740
has cross-reference: ORDO:100924
has cross-reference: SNOMEDCT_US_2020_03_01:55056006
has cross-reference: UMLS_CUI:C0162533
alternative_term: hepatic porphyria
has_obo_namespace: disease_ontology
id: DOID:3133
in subset: DO rare slim
comment: Xref MGI.

facial dermatosis
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: MESH:D005148
has cross-reference: UMLS_CUI:C0015456
has_obo_namespace: disease_ontology
id: DOID:3134

scalp dermatosis
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: MESH:D012536
has cross-reference: SNOMEDCT_US_2020_03_01:402694007
has cross-reference: UMLS_CUI:C0036271
alternative_term: Dermatosis of scalp
has_obo_namespace: disease_ontology
id: DOID:3136

acanthosis nigricans
type: Class
subclass of: pigmentation disease
imported from: doid.owl
has cross-reference: GARD:8603
has cross-reference: ICD10CM:L83
has cross-reference: MESH:D000052
has cross-reference: NCI:C26687
has cross-reference: OMIM:100600
has cross-reference: OMIM:200170
has cross-reference: SNOMEDCT_US_2020_03_01:72129000
has cross-reference: UMLS_CUI:C0000889
alternative_term: AN - Acanthosis nigricans
alternative_term: Acanthosis nigricans
alternative_term: Keratosis nigricans
alternative_term: keratosis nigricans
has_obo_namespace: disease_ontology
id: DOID:3138
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mucinoses
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease characterized by accumulation of glycosaminoglycan located_in the dermal tissue.
imported from: doid.owl
has cross-reference: MESH:D017520
has cross-reference: SNOMEDCT_US_2020_03_01:11528001
has cross-reference: UMLS_CUI:C0162855
has_obo_namespace: disease_ontology
id: DOID:3141

cutis laxa
type: Class
subclass of: skin disease
textual definition: A skin disease characterized by loose, hanging, wrinkled skin lacking in elasticity.
imported from: doid.owl
has cross-reference: GARD:6227
has cross-reference: ICD10CM:Q82.8
has cross-reference: MESH:D003483
has cross-reference: NCI:C84663
has cross-reference: OMIM:PS123700
has cross-reference: ORDO:209
has cross-reference: SNOMEDCT_US_2020_03_01:238825007
has cross-reference: UMLS_CUI:C0010495
alternative_term: Cutis laxa
alternative_term: loose skin
has_obo_namespace: disease_ontology
id: DOID:3144
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

lipid metabolism disorder
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder that involves the creation and degradation of lipids.
imported from: doid.owl
has cross-reference: MESH:D008052
has cross-reference: UMLS_CUI:C0023772
alternative_term: dyslipidemia
alternative_term: fatty acid metabolism disorder
has_obo_namespace: disease_ontology
id: DOID:3146
in subset: DO FlyBase slim

lipomatosis
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: ICD10CM:E88.2
has cross-reference: MESH:D008068
has cross-reference: SNOMEDCT_US_2020_03_01:37095002
has cross-reference: UMLS_CUI:C0023801
has_obo_namespace: disease_ontology
id: DOID:3153

hand dermatosis
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: MESH:D006229
has cross-reference: UMLS_CUI:C0018567
has_obo_namespace: disease_ontology
id: DOID:3158

skin benign neoplasm
type: Class
subclass of: integumentary system benign neoplasm
subclass of: skin disease
imported from: doid.owl
has cross-reference: MESH:D012878
has cross-reference: NCI:C3372
has cross-reference: SNOMEDCT_US_2020_03_01:126488004
has cross-reference: UMLS_CUI:C0037286
alternative_term: neoplasm of skin
alternative_term: neoplasm of skin by site
alternative_term: skin neoplasm
alternative_term: tumor of the skin
has_obo_namespace: disease_ontology
id: DOID:3165
in subset: NCIthesaurus

squamous cell neoplasm
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities.
imported from: doid.owl
has cross-reference: MESH:D018307
has cross-reference: NCI:C3792
has cross-reference: SNOMEDCT_US_2020_03_01:118286007
has cross-reference: UMLS_CUI:C0206720
alternative_term: Epidermoid cell tumor
alternative_term: squamous cell tumor
has_obo_namespace: disease_ontology
id: DOID:3168
in subset: NCIthesaurus

papillary adenoma
type: Class
subclass of: adenoma
imported from: doid.owl
has cross-reference: MESH:D000236
has cross-reference: NCI:C79951
has cross-reference: SNOMEDCT_US_2020_03_01:86143001
has cross-reference: UMLS_CUI:C0205650
alternative_term: Papillary adenoma
alternative_term: glandular papilloma
has_obo_namespace: disease_ontology
id: DOID:3172
in subset: NCIthesaurus

verrucous papilloma
type: Class
subclass of: papilloma
imported from: doid.owl
has cross-reference: NCI:C4101
has cross-reference: SNOMEDCT_US_2020_03_01:48218007
has cross-reference: UMLS_CUI:C0334243
has_obo_namespace: disease_ontology
id: DOID:3177
in subset: NCIthesaurus

skin papilloma
type: Class
subclass of: papilloma
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4614
has cross-reference: SNOMEDCT_US_2020_03_01:189051001
has cross-reference: UMLS_CUI:C0347390
alternative_term: Cutaneous papilloma
alternative_term: cutaneous papilloma
alternative_term: papilloma of skin
has_obo_namespace: disease_ontology
id: DOID:3178
in subset: NCIthesaurus

inverted papilloma
type: Class
subclass of: papilloma
imported from: doid.owl
has cross-reference: MESH:D018308
has cross-reference: NCI:C3793
has cross-reference: SNOMEDCT_US_2020_03_01:104081000119103
has cross-reference: UMLS_CUI:C0206721
alternative_term: Inverted papilloma
alternative_term: Inverted papilloma, squamous cell
has_obo_namespace: disease_ontology
id: DOID:3179
in subset: NCIthesaurus

progressive muscular atrophy
type: Class
subclass of: motor neuron disease
imported from: doid.owl
has cross-reference: ICD9CM:335.21
has cross-reference: MESH:D009134
has cross-reference: NCI:C85027
has cross-reference: SNOMEDCT_US_2020_03_01:88923002
has cross-reference: UMLS_CUI:C0917981
alternative_term: Pure progressive muscular atrophy
alternative_term: progressive spinal muscular atrophy
has_obo_namespace: disease_ontology
id: DOID:318
in subset: NCIthesaurus

oligodendroglioma
type: Class
subclass of: malignant glioma
imported from: doid.owl
has_alternative_id: DOID:3182
has cross-reference: GARD:9953
has cross-reference: MESH:D009837
has cross-reference: NCI:C129319
has cross-reference: NCI:C6960
has cross-reference: SNOMEDCT_US_2020_03_01:73348003
has cross-reference: UMLS_CUI:C0028945
has cross-reference: UMLS_CUI:C1335110
alternative_term: oligodendroglial neoplasm
alternative_term: oligodendroglial tumor
has_obo_namespace: disease_ontology
id: DOID:3181
in subset: NCIthesaurus

spinal cord glioma
type: Class
subclass of: malignant glioma
subclass of: spinal cancer
textual definition: A spinal cancer that is located in the spinal cord and has_material_basis_in glial cells.
imported from: doid.owl
has cross-reference: NCI:C4534
has cross-reference: SNOMEDCT_US_2020_03_01:254946004
has cross-reference: UMLS_CUI:C2937245
alternative_term: Glial neoplasm Spinal Cord
alternative_term: Glial tumor of spinal cord
alternative_term: glioma of spinal cord
has_obo_namespace: disease_ontology
id: DOID:3185
in subset: NCIthesaurus

spinal cord disease
type: Class
subclass of: central nervous system disease
imported from: doid.owl
has cross-reference: ICD10CM:G95.9
has cross-reference: ICD9CM:336.9
has cross-reference: MESH:D013118
has cross-reference: NCI:C97110
has cross-reference: SNOMEDCT_US_2020_03_01:48522003
has cross-reference: UMLS_CUI:C0037928
has_obo_namespace: disease_ontology
has_related_synonym: myelopathy
id: DOID:319
in subset: NCIthesaurus

nemaline myopathy
type: Class
subclass of: congenital structural myopathy
textual definition: A congenital structural myopathy characterized by generally non-progressive muscle weakness of varying severity; certain muscle fibers show the presence of rod-like structures called nemaline bodies.
imported from: doid.owl
has cross-reference: GARD:12033
has cross-reference: ICD10CM:G71.2
has cross-reference: MESH:D017696
has cross-reference: OMIM:PS161800
has cross-reference: ORDO:607
has cross-reference: SNOMEDCT_US_2020_03_01:75072002
has cross-reference: UMLS_CUI:C0206157
alternative_term: Nemaline body disease
alternative_term: nemaline rod myopathy
alternative_term: rod myopathy
has_obo_namespace: disease_ontology
id: DOID:3191
in subset: DO FlyBase slim
in subset: DO rare slim
comment: Xref MGI.

neurilemmoma
type: Class
subclass of: neuroma
imported from: doid.owl
has cross-reference: MESH:D009442
has cross-reference: NCI:C3269
has cross-reference: SNOMEDCT_US_2020_03_01:985004
has cross-reference: UMLS_CUI:C0027809
alternative_term: Psammomatous schwannoma
alternative_term: schwannoma
has_obo_namespace: disease_ontology
id: DOID:3192
in subset: NCIthesaurus
comment: A neuroma that is characterized as a benign nerve sheath tumor that is composed of Schwann cells.

peripheral nerve sheath neoplasm
type: Class
subclass of: peripheral nervous system neoplasm
textual definition: A peripheral nervous system neoplasm that is located in the connective tissue surrounding nerves.
imported from: doid.owl
has cross-reference: MESH:D018317
has cross-reference: UMLS_CUI:C0751689
alternative_term: neoplasm of the nerve Sheath
alternative_term: nerve sheath tumour
has_obo_namespace: disease_ontology
id: DOID:3193
in subset: DO cancer slim

cerebellopontine angle tumor
type: Class
subclass of: brain stem cancer
textual definition: A brain stem cancer that is characterized by neoplasms in the fossa located_in cerebellopotine angle.
imported from: doid.owl
has cross-reference: NCI:C5414
alternative_term: Cerebellopontine angle tumor
alternative_term: Cerebellopontine angle tumour
alternative_term: cerebellopontine angle tumour
alternative_term: neoplasm of the Cerebellopontine Angle
has_obo_namespace: disease_ontology
id: DOID:3200
in subset: NCIthesaurus

melanotic neurilemmoma
type: Class
subclass of: neurilemmoma
imported from: doid.owl
has cross-reference: NCI:C6970
has cross-reference: SNOMEDCT_US_2020_03_01:253088003
has cross-reference: UMLS_CUI:C1306247
alternative_term: Melanotic Schwannoma
alternative_term: Melanotic neurilemmoma
alternative_term: Pigmented Neurilemmoma
alternative_term: Pigmented schwannoma
has_obo_namespace: disease_ontology
id: DOID:3205
in subset: NCIthesaurus

junctional epidermolysis bullosa
type: Class
subclass of: epidermolysis bullosa
textual definition: An epidermolysis bullosa that is characterized by recurrent blistering located in the lamina lucida of the basement membrane secondary to minor trauma, which can cause limited wounds, dehydration, electrolyte abnormalities, severe infection, among other issues, and has_material_basis_in mutation in genes related to laminin 332, which strengthens the skin.
imported from: doid.owl
has cross-reference: GARD:2152
has cross-reference: MESH:D016109
has cross-reference: NCI:C90598
has cross-reference: SNOMEDCT_US_2020_03_01:76905008
has cross-reference: UMLS_CUI:C0079301
alternative_term: congenital junctional epidermolysis bullosa
has_obo_namespace: disease_ontology
id: DOID:3209
in subset: NCIthesaurus
comment: Xref MGI.

tropical spastic paraparesis
type: Class
subclass of: spinal cord disease
subclass of: DOID 934
textual definition: A viral infectious disease that results in inflammation located in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.
imported from: doid.owl
has cross-reference: ICD10CM:G04.1
has cross-reference: MESH:D015493
has cross-reference: OMIM:159580
has cross-reference: SNOMEDCT_US_2020_03_01:45129002
has cross-reference: UMLS_CUI:C0030481
alternative_term: HTLV-associated myelopathy
alternative_term: Tropical spastic paralysis
alternative_term: Tropical spastic paraplegia
has_obo_namespace: disease_ontology
id: DOID:321
comment: OMIM mapping confirmed by DO. [LS].

Pelizaeus-Merzbacher disease
type: Class
subclass of: hypomyelinating leukodystrophy
subclass of: X-linked recessive disease
textual definition: A hypomyelinating leukodystrophy characterized by impaired myelin formation, nystagmus, spastic quadriplegia, ataxia, and developmental delay that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22.
imported from: doid.owl
has cross-reference: GARD:4265
has cross-reference: MESH:D020371
has cross-reference: NCI:C75487
has cross-reference: OMIM:312080
has cross-reference: ORDO:702
has cross-reference: SNOMEDCT_US_2020_03_01:64855000
has cross-reference: UMLS_CUI:C0205711
alternative_term: HLD1
alternative_term: Leukodystrophy, sudanophilic
alternative_term: PMD
alternative_term: Pelizaeus Merzbacher brain sclerosis
alternative_term: Pelizaeus-Merzbacher brain sclerosis
alternative_term: diffuse familial brain sclerosis
alternative_term: hypomyelinating leukodystrophy 1
alternative_term: sudanophilic leukodystrophy, Paelizeus-Merzbacher type
has_obo_namespace: disease_ontology
id: DOID:3210
in subset: NCIthesaurus

lysosomal storage disease
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.
imported from: doid.owl
has cross-reference: MESH:D016464
has cross-reference: NCI:C61250
has cross-reference: SNOMEDCT_US_2020_03_01:23585005
has cross-reference: UMLS_CUI:C0085078
alternative_term: disorder of lysosomal enzyme
alternative_term: inborn lysosomal enzyme disorder
alternative_term: lysosomal storage metabolism disorder
has_obo_namespace: disease_ontology
id: DOID:3211
in subset: DO FlyBase slim
in subset: NCIthesaurus

demyelinating disease
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease that is characterized by damage to the myelin sheath present around nerve axons.
imported from: doid.owl
has cross-reference: MESH:D003711
has cross-reference: NCI:C34527
has cross-reference: UMLS_CUI:C0011303
alternative_term: demyelinating disorder
has_obo_namespace: disease_ontology
id: DOID:3213
in subset: NCIthesaurus

myelitis
type: Class
subclass of: spinal cord disease
textual definition: A spinal cord disease that is characterized by inflammation of the white matter or gray matter of the spinal cord.
imported from: doid.owl
has cross-reference: GARD:7130
has cross-reference: MESH:D009187
has cross-reference: NCI:C26832
has cross-reference: SNOMEDCT_US_2020_03_01:192682002
has cross-reference: UMLS_CUI:C0026975
has_obo_namespace: disease_ontology
id: DOID:322
in subset: NCIthesaurus

complex regional pain syndrome
type: Class
subclass of: autonomic nervous system disease
imported from: doid.owl
has cross-reference: GARD:4647
has cross-reference: MESH:D020918
has cross-reference: SNOMEDCT_US_2020_03_01:128200000
has cross-reference: UMLS_CUI:C0458219
alternative_term: Complex regional pain syndromes
has_obo_namespace: disease_ontology
id: DOID:3223

tracheal disease
type: Class
subclass of: DOID 974
imported from: doid.owl
has cross-reference: ICD10CM:S12.8
has cross-reference: MESH:D014133
has cross-reference: NCI:C35079
has cross-reference: SNOMEDCT_US_2020_03_01:47125007
has cross-reference: UMLS_CUI:C0040580
has_obo_namespace: disease_ontology
id: DOID:3225
in subset: NCIthesaurus

tracheal stenosis
type: Class
subclass of: tracheal disease
imported from: doid.owl
has cross-reference: MESH:D014135
has cross-reference: NCI:C78646
has cross-reference: SNOMEDCT_US_2020_03_01:11296007
has cross-reference: UMLS_CUI:C0040583
alternative_term: Stenosis of trachea
has_obo_namespace: disease_ontology
id: DOID:3227
in subset: NCIthesaurus

gastric dilatation
type: Class
subclass of: stomach disease
imported from: doid.owl
has cross-reference: MESH:D013271
has cross-reference: UMLS_CUI:C0038353
alternative_term: stomach dilatation
has_obo_namespace: disease_ontology
id: DOID:3229

high pressure neurological syndrome
type: Class
subclass of: central nervous system disease
imported from: doid.owl
has cross-reference: MESH:D006610
has cross-reference: UMLS_CUI:C0019537
has_obo_namespace: disease_ontology
id: DOID:3230

central nervous system lymphoma
type: Class
subclass of: lymphoma
subclass of: central nervous system hematologic cancer
textual definition: A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system.
imported from: doid.owl
has_alternative_id: DOID:3233
has cross-reference: ICD9CM:200.5
has cross-reference: NCI:C9301
has cross-reference: SNOMEDCT_US_2020_03_01:307649006
has cross-reference: UMLS_CUI:C0280803
alternative_term: Microglioma
alternative_term: primary CNS lymphoma
has_obo_namespace: disease_ontology
id: DOID:3234
in subset: NCIthesaurus

aspiration pneumonitis
type: Class
subclass of: pneumonia
textual definition: A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disease has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.
imported from: doid.owl
has_alternative_id: DOID:13016
has_alternative_id: DOID:13506
has cross-reference: ICD10CM:J69.0
has cross-reference: MESH:D011015
has cross-reference: SNOMEDCT_US_2020_03_01:47839005
has cross-reference: UMLS_CUI:C0032290
alternative_term: Chemical pneumonitis
alternative_term: Mendelson's Syndrome
has_obo_namespace: disease_ontology
id: DOID:3240
in subset: NCIthesaurus

lipid pneumonia
type: Class
subclass of: aspiration pneumonitis
textual definition: An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent.
imported from: doid.owl
has_alternative_id: DOID:13015
has cross-reference: ICD10CM:J69.1
has cross-reference: MESH:D011017
has cross-reference: SNOMEDCT_US_2020_03_01:196038008
has cross-reference: UMLS_CUI:C0032298
alternative_term: Exogenous lipoid pneumonia
alternative_term: Lipoid pneumonitis
has_obo_namespace: disease_ontology
id: DOID:3241

embryonal rhabdomyosarcoma
type: Class
subclass of: rhabdomyosarcoma
textual definition: A rhabdomyosarcoma wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo; it occurs most often in the head and neck area or in the genital or urinary organs.
imported from: doid.owl
has cross-reference: GARD:4702
has cross-reference: MESH:D018233
has cross-reference: NCI:C8971
has cross-reference: OMIM:268210
has cross-reference: ORDO:99757
has cross-reference: SNOMEDCT_US_2020_03_01:404051002
has cross-reference: UMLS_CUI:C0206656
has_obo_namespace: disease_ontology
id: DOID:3246
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

rhabdomyosarcoma
type: Class
subclass of: skeletal muscle cancer
textual definition: A skeletal muscle cancer that arise from skeletal muscle progenitors.
imported from: doid.owl
has cross-reference: MESH:D012208
has cross-reference: NCI:C3359
has cross-reference: SNOMEDCT_US_2020_03_01:302847003
has cross-reference: UMLS_CUI:C0035412
has_obo_namespace: disease_ontology
id: DOID:3247
in subset: NCIthesaurus

prostate rhabdomyosarcoma
type: Class
subclass of: prostate sarcoma
textual definition: A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate.
imported from: doid.owl
has cross-reference: NCI:C5522
has cross-reference: UMLS_CUI:C1335518
alternative_term: Rhabdomyosarcoma of the prostate
has_obo_namespace: disease_ontology
id: DOID:3252
in subset: NCIthesaurus

ischemia
type: Class
subclass of: vascular disease
textual definition: A vascular disease that is characterized by a restriction in blood supply to tissues.
imported from: doid.owl
has cross-reference: MESH:D007511
has cross-reference: NCI:C34738
has cross-reference: SNOMEDCT_US_2020_03_01:52674009
has cross-reference: UMLS_CUI:C0022116
has_obo_namespace: disease_ontology
id: DOID:326
in subset: NCIthesaurus

hyper IgE recurrent infection syndrome 1
type: Class
subclass of: autosomal dominant disease
subclass of: hyper IgE syndrome
textual definition: A hyper IgE syndrome that has_material_basis_in heterozygous mutation in the STAT3 gene on chromosome 17q21.
imported from: doid.owl
has cross-reference: GARD:6800
has cross-reference: MESH:D007589
has cross-reference: NCI:C126342
has cross-reference: OMIM:147060
has cross-reference: ORDO:2314
has cross-reference: UMLS_CUI:C1968689
has cross-reference: UMLS_CUI:C2936739
alternative_term: Job syndrome
alternative_term: Job's syndrome
alternative_term: hyperimmunoglobulin E syndrome
has_obo_namespace: disease_ontology
id: DOID:3261
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

phagocyte bactericidal dysfunction
type: Class
subclass of: primary immunodeficiency disease
textual definition: A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection.
imported from: doid.owl
has cross-reference: MESH:D010585
has cross-reference: UMLS_CUI:C0031306
alternative_term: phagocytic dysfunction
has_obo_namespace: disease_ontology
id: DOID:3262

piebaldism
type: Class
subclass of: autosomal dominant disease
subclass of: integumentary system disease
textual definition: An integumentary system disease characterized by congenital absence of melanocytes in areas of the skin and hair that has_material_basis_in heterozygous mutation in either KIT or SNAI2 on chromosome 4q12 or 8q11.21, respectively.
imported from: doid.owl
has cross-reference: GARD:4344
has cross-reference: ICD10CM:E70.39
has cross-reference: MESH:D016116
has cross-reference: NCI:C85009
has cross-reference: OMIM:172800
has cross-reference: ORDO:2884
has cross-reference: SNOMEDCT_US_2020_03_01:718122005
has cross-reference: UMLS_CUI:C0080024
alternative_term: PIEBALD TRAIT
alternative_term: Partial albinism
has_obo_namespace: disease_ontology
id: DOID:3263
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chronic granulomatous disease
type: Class
subclass of: bone disease
subclass of: phagocyte bactericidal dysfunction
subclass of: skin disease
subclass of: lung disease
textual definition: A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed.
imported from: doid.owl
has cross-reference: GARD:6100
has cross-reference: ICD10CM:D71
has cross-reference: MESH:D006105
has cross-reference: NCI:C26788
has cross-reference: ORDO:379
has cross-reference: SNOMEDCT_US_2020_03_01:11210002
has cross-reference: UMLS_CUI:C0018203
alternative_term: Bridges-Good syndrome
alternative_term: CGD
alternative_term: Congenital dysphagocytosis
alternative_term: Quie syndrome
has_obo_namespace: disease_ontology
id: DOID:3265
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

ovarian cystadenoma
type: Class
subclass of: ovarian benign neoplasm
textual definition: An ovarian benign neoplasm that has_material_basis_in glandular epithelial tissue in which cystic accumulations of retained secretions are formed.
imported from: doid.owl
has cross-reference: NCI:C4060
has cross-reference: SNOMEDCT_US_2020_03_01:198297004
has cross-reference: UMLS_CUI:C0346169
alternative_term: Cystoma Serosum simplex
alternative_term: simple cystoma of ovary
alternative_term: simple cystoma of the ovary
has_obo_namespace: disease_ontology
id: DOID:3269
in subset: NCIthesaurus

syringomyelia
type: Class
subclass of: spinal cord disease
imported from: doid.owl
has cross-reference: GARD:7725
has cross-reference: MESH:D013595
has cross-reference: NCI:C85179
has cross-reference: OMIM:186700
has cross-reference: ORDO:3280
has cross-reference: SNOMEDCT_US_2020_03_01:155020007
has cross-reference: UMLS_CUI:C0039144
has_obo_namespace: disease_ontology
id: DOID:327
in subset: NCIthesaurus

thymoma
type: Class
subclass of: thymus cancer
textual definition: A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus.
imported from: doid.owl
has cross-reference: MESH:D013945
has cross-reference: NCI:C3411
has cross-reference: SNOMEDCT_US_2020_03_01:444231005
has cross-reference: UMLS_CUI:C0040100
has_obo_namespace: disease_ontology
id: DOID:3275
in subset: DO cancer slim
in subset: NCIthesaurus

thymus cancer
type: Class
subclass of: lymphatic system cancer
subclass of: endocrine gland cancer
subclass of: thymus gland disease
textual definition: An immune system cancer located_in the thymus.
imported from: doid.owl
has_alternative_id: DOID:10143
has cross-reference: ICD10CM:C37
has cross-reference: ICD9CM:164.0
has cross-reference: MESH:D013953
has cross-reference: NCI:C4962
has cross-reference: SNOMEDCT_US_2020_03_01:94096009
has cross-reference: UMLS_CUI:C0751552
alternative_term: Thymic tumor
alternative_term: neoplasm of thymus
alternative_term: thymic neoplasm
has_obo_namespace: disease_ontology
id: DOID:3277
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

dendritic cell thymoma
type: Class
subclass of: hematologic cancer
subclass of: thymoma
subclass of: DOID 9500
imported from: doid.owl
has cross-reference: NCI:C7114
has cross-reference: UMLS_CUI:C1328042
alternative_term: epithelioid Thymoma
has_obo_namespace: disease_ontology
id: DOID:3282
in subset: NCIthesaurus

thymic carcinoma
type: Class
subclass of: carcinoma
subclass of: thymus cancer
textual definition: A thymus cancer that derives_from epithelial cells. The tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found.
imported from: doid.owl
has cross-reference: MESH:D013945
has cross-reference: NCI:C7569
has cross-reference: SNOMEDCT_US_2020_03_01:128717008
has cross-reference: UMLS_CUI:C0205969
alternative_term: Thymic carcinoma
alternative_term: Thymoma, malignant
alternative_term: malignant Thymoma
has_obo_namespace: disease_ontology
id: DOID:3284
in subset: NCIthesaurus

monkeypox
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has_material_basis_in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy.
imported from: doid.owl
has cross-reference: GARD:10722
has cross-reference: ICD10CM:B04
has cross-reference: ICD9CM:059.01
has cross-reference: MESH:D045908
has cross-reference: NCI:C128421
has cross-reference: SNOMEDCT_US_2020_03_01:240466002
has cross-reference: UMLS_CUI:C0276180
has_obo_namespace: disease_ontology
id: DOID:3292
in subset: NCIthesaurus
in subset: zoonotic infectious disease

vaccinia
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.
imported from: doid.owl
has cross-reference: MESH:D014615
has cross-reference: SNOMEDCT_US_2020_03_01:111852003
has cross-reference: UMLS_CUI:C0042214
has_obo_namespace: disease_ontology
id: DOID:3298

gonadoblastoma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm that is composed_of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells (which comprises the granulosa, theca, and fibrocyte cells).
imported from: doid.owl
has cross-reference: MESH:D018238
has cross-reference: NCI:C3754
has cross-reference: OMIM:424500
has cross-reference: SNOMEDCT_US_2020_03_01:74751003
has cross-reference: UMLS_CUI:C0206661
has_obo_namespace: disease_ontology
id: DOID:3301
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chordoma
type: Class
subclass of: notochordal cancer
textual definition: A notochordal cancer that derives_from cellular remnants of the notochord.
imported from: doid.owl
has cross-reference: GARD:1303
has cross-reference: MESH:D002817
has cross-reference: NCI:C2947
has cross-reference: SNOMEDCT_US_2020_03_01:50007008
has cross-reference: UMLS_CUI:C0008487
alternative_term: notochordoma
has_obo_namespace: disease_ontology
id: DOID:3302
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

notochordal cancer
type: Class
subclass of: bone cancer
textual definition: An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord.
imported from: doid.owl
has cross-reference: NCI:C7063
has cross-reference: UMLS_CUI:C1335069
has_obo_namespace: disease_ontology
has_related_synonym: notochordal tumor
id: DOID:3303
in subset: NCIthesaurus

germinoma
type: Class
subclass of: germ cell cancer
textual definition: A germ cell cancer that lacks histologic differentiation. It usually refers to a tumor in the brain.
imported from: doid.owl
has cross-reference: MESH:D018237
has cross-reference: NCI:C3753
has cross-reference: SNOMEDCT_US_2020_03_01:154603000
has cross-reference: UMLS_CUI:C0206660
has_obo_namespace: disease_ontology
id: DOID:3304
in subset: NCIthesaurus

teratocarcinoma
type: Class
subclass of: germ cell and embryonal cancer
textual definition: A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.
imported from: doid.owl
has cross-reference: MESH:D018243
has cross-reference: NCI:C3756
has cross-reference: SNOMEDCT_US_2020_03_01:67830002
has cross-reference: UMLS_CUI:C0206664
alternative_term: Teratocarcinoma
alternative_term: mixed Embryonal carcinoma and teratoma
has_obo_namespace: disease_ontology
id: DOID:3305
in subset: NCIthesaurus

teratoma
type: Class
subclass of: germ cell and embryonal cancer
textual definition: A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.
imported from: doid.owl
has cross-reference: MESH:D013724
has cross-reference: NCI:C3403
has cross-reference: SNOMEDCT_US_2020_03_01:36591000119102
has cross-reference: UMLS_CUI:C0039538
has_obo_namespace: disease_ontology
id: DOID:3307
in subset: NCIthesaurus

embryonal carcinoma
type: Class
subclass of: carcinoma
subclass of: embryonal cancer
textual definition: An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes.
imported from: doid.owl
has_alternative_id: DOID:5676
has cross-reference: GARD:5140
has cross-reference: MESH:D018236
has cross-reference: NCI:C3752
has cross-reference: NCI:C8880
has cross-reference: SNOMEDCT_US_2020_03_01:28047004
has cross-reference: UMLS_CUI:C0206659
has cross-reference: UMLS_CUI:C0855159
alternative_term: primary extragonadal embryonal carcinoma
has_obo_namespace: disease_ontology
id: DOID:3308
in subset: NCIthesaurus

central nervous system disease
type: Class
subclass of: DOID 863
textual definition: A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.
imported from: doid.owl
has cross-reference: ICD10CM:G96.9
has cross-reference: MESH:D002493
has cross-reference: NCI:C2934
has cross-reference: SNOMEDCT_US_2020_03_01:267144009
has cross-reference: UMLS_CUI:C0007682
has_obo_namespace: disease_ontology
id: DOID:331
in subset: DO AGR slim
in subset: DO GXD slim
in subset: NCIthesaurus

atopic dermatitis
type: Class
subclass of: allergic contact dermatitis
textual definition: An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.
imported from: doid.owl
has cross-reference: EFO:0000274
has cross-reference: ICD10CM:L20
has cross-reference: MESH:D003876
has cross-reference: OMIM:603165
has cross-reference: OMIM:PS603165
has cross-reference: SNOMEDCT_US_2020_03_01:156331003
has cross-reference: UMLS_CUI:C0011615
alternative_term: Atopic dermatitis
alternative_term: Atopic neurodermatitis
alternative_term: Besnier's prurigo
alternative_term: allergic dermatitis
alternative_term: atopic eczema
has_obo_namespace: disease_ontology
id: DOID:3310
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

bipolar disorder
type: Class
subclass of: mood disorder
textual definition: A mood disorder that involves alternating periods of mania and depression.
imported from: doid.owl
has_alternative_id: DOID:3311
has_alternative_id: DOID:9554
has_alternative_id: DOID:9555
has cross-reference: EFO:0000289
has cross-reference: GARD:10249
has cross-reference: ICD10CM:F31
has cross-reference: ICD9CM:296.40
has cross-reference: ICD9CM:296.60
has cross-reference: ICD9CM:296.80
has cross-reference: MESH:D001714
has cross-reference: NCI:C34423
has cross-reference: NCI:C34424
has cross-reference: NCI:C34805
has cross-reference: SNOMEDCT_US_2020_03_01:16506000
has cross-reference: SNOMEDCT_US_2020_03_01:191627008
has cross-reference: SNOMEDCT_US_2020_03_01:192355004
has cross-reference: SNOMEDCT_US_2020_03_01:68569003
has cross-reference: UMLS_CUI:C0005586
has cross-reference: UMLS_CUI:C0005587
has cross-reference: UMLS_CUI:C0024713
has cross-reference: UMLS_CUI:C0236780
alternative_term: Manic Bipolar Affective disorder
alternative_term: Manic Depressive disorder
alternative_term: Manic bipolar I disorder
alternative_term: bipolar depression
alternative_term: bipolar disorder manic phase
alternative_term: manic depression
alternative_term: manic disorder
alternative_term: mixed bipolar disorder
has_obo_namespace: disease_ontology
has_related_synonym: Depressive-manic psych.
id: DOID:3312
in subset: NCIthesaurus

angiomyolipoma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm that is primarily located in the kidneys but may be found in the lungs, liver or other organs and is derived from perivascular epithelioid cells.
imported from: doid.owl
has cross-reference: MESH:D018207
has cross-reference: NCI:C3734
has cross-reference: SNOMEDCT_US_2020_03_01:19929002
has cross-reference: UMLS_CUI:C0206633
alternative_term: Angiomyolipoma
has_obo_namespace: disease_ontology
id: DOID:3314
in subset: NCIthesaurus

lipoma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm that is composed of lipocytes.
imported from: doid.owl
has_alternative_id: DOID:3154
has_alternative_id: DOID:9291
has cross-reference: ICD10CM:D17
has cross-reference: ICD10CM:D17.9
has cross-reference: ICD9CM:214
has cross-reference: MESH:D008067
has cross-reference: MESH:D018205
has cross-reference: NCI:C3192
has cross-reference: NCI:C4248
has cross-reference: NCI:C4502
has cross-reference: OMIM:151900
has cross-reference: SNOMEDCT_US_2020_03_01:115227001
has cross-reference: SNOMEDCT_US_2020_03_01:154612003
has cross-reference: SNOMEDCT_US_2020_03_01:254830006
has cross-reference: UMLS_CUI:C0023798
has cross-reference: UMLS_CUI:C0206631
has cross-reference: UMLS_CUI:C0346118
alternative_term: LIPOMATOSIS, FAMILIAL MULTIPLE
alternative_term: Lipomatous neoplasm
alternative_term: Lipomatous tumor
alternative_term: benign lipomatous tumor
alternative_term: benign tumor of Adipose tissue
alternative_term: multiple lipomatosis
alternative_term: tumor of adipose tissue
has_obo_namespace: disease_ontology
id: DOID:3315
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

perivascular tumor
type: Class
subclass of: vascular cancer
imported from: doid.owl
has_alternative_id: DOID:5234
has cross-reference: NCI:C6528
has cross-reference: NCI:C6530
has cross-reference: UMLS_CUI:C1334611
has cross-reference: UMLS_CUI:C1335392
alternative_term: malignant perivascular cancer
has_obo_namespace: disease_ontology
id: DOID:3316
in subset: NCIthesaurus

lymphangioleiomyomatosis
type: Class
subclass of: lung disease
textual definition: A lung disease that is characterized by progressive cystic destruction of the lung and lymphatic abnormalities, frequently associated with renal angiomyolipomas.
imported from: doid.owl
has_alternative_id: DOID:3682
has cross-reference: GARD:3319
has cross-reference: NCI:C38153
has cross-reference: OMIM:606690
has cross-reference: ORDO:538
has cross-reference: SNOMEDCT_US_2020_03_01:277844007
has cross-reference: UMLS_CUI:C0349649
alternative_term: lung lymphangioleiomyomatosis
alternative_term: lymphangiomyomatosis
alternative_term: pulmonary lymphangioleiomyomatosis
has_obo_namespace: disease_ontology
id: DOID:3319
in subset: NCIthesaurus

amyotrophic lateral sclerosis
type: Class
subclass of: monogenic disease
subclass of: motor neuron disease
textual definition: A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
imported from: doid.owl
has cross-reference: EFO:0000253
has cross-reference: GARD:5786
has cross-reference: ICD10CM:G12.21
has cross-reference: ICD9CM:335.20
has cross-reference: KEGG:05014
has cross-reference: MESH:D000690
has cross-reference: NCI:C34373
has cross-reference: OMIM:PS105400
has cross-reference: ORDO:803
has cross-reference: SNOMEDCT_US_2020_03_01:86044005
has cross-reference: UMLS_CUI:C0002736
alternative_term: ALS
alternative_term: Lou Gehrig's disease
alternative_term: motor neuron disease, bulbar
has_obo_namespace: disease_ontology
id: DOID:332
in subset: DO FlyBase slim
in subset: NCIthesaurus

Tay-Sachs disease
type: Class
subclass of: GM2 gangliosidosis
imported from: doid.owl
has cross-reference: GARD:7737
has cross-reference: ICD10CM:E75.02
has cross-reference: MESH:D013661
has cross-reference: NCI:C85184
has cross-reference: OMIM:272800
has cross-reference: SNOMEDCT_US_2020_03_01:111385000
has cross-reference: UMLS_CUI:C0039373
alternative_term: A GM2 gangliosidosis that is characterized the onset in infancy of developmental retardation, followed by paralysis, dementia and blindness, with death in the second or third year of life and has_material_basis_in homozygous or compound heterozygous mutation in the alpha subunit of the hexosaminidase A gene (HEXA) on chromosome 15q23.
alternative_term: GM2 gangliosidosis, type 1
alternative_term: hexosaminidase A deficiency
has_obo_namespace: disease_ontology
id: DOID:3320
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

GM2 gangliosidosis
type: Class
subclass of: gangliosidosis
textual definition: A gangliosidosis that is characterized by excessive accumulation of ganglioside GM2 and related glycolipids in the lysosomes.
imported from: doid.owl
has cross-reference: ICD10CM:E75.0
has cross-reference: MESH:D020143
has cross-reference: SNOMEDCT_US_2020_03_01:33316007
has cross-reference: UMLS_CUI:C0268274
alternative_term: gangliosidosis GM2
has_obo_namespace: disease_ontology
id: DOID:3321

Sandhoff disease
type: Class
subclass of: GM2 gangliosidosis
textual definition: A GM2 gangliosidosis that is characterized by an accumulation of GM2 gangliosides, particularly in neurons, and that has_material_basis_in mutation in the beta subunit of hexosaminidase (HEXB) on chromosome 5q13.
imported from: doid.owl
has cross-reference: GARD:7604
has cross-reference: ICD10CM:E75.01
has cross-reference: MESH:D012497
has cross-reference: NCI:C85052
has cross-reference: OMIM:268800
has cross-reference: SNOMEDCT_US_2020_03_01:23849003
has cross-reference: UMLS_CUI:C0036161
alternative_term: Sandhoff Jatzkewitz disease
has_obo_namespace: disease_ontology
id: DOID:3323
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mood disorder
type: Class
subclass of: cognitive disorder
textual definition: A cognitive disorder that involves a disturbance in mood as the predominant underlying feature.
imported from: doid.owl
has cross-reference: EFO:0004247
has cross-reference: ICD10CM:F39
has cross-reference: MESH:D019964
has cross-reference: NCI:C92200
has cross-reference: SNOMEDCT_US_2020_03_01:46206005
has cross-reference: UMLS_CUI:C0525045
alternative_term: episodic mood disorder
has_obo_namespace: disease_ontology
id: DOID:3324
in subset: NCIthesaurus
comment: Updating outdated UMLS CUI.

hyperglobulinemic purpura
type: Class
subclass of: purpura
imported from: doid.owl
has cross-reference: MESH:D011694
has cross-reference: SNOMEDCT_US_2020_03_01:402852007
has cross-reference: UMLS_CUI:C0034151
has_obo_namespace: disease_ontology
id: DOID:3325

purpura
type: Class
subclass of: hemorrhagic disease
imported from: doid.owl
has cross-reference: ICD10CM:D69.2
has cross-reference: MESH:D011693
has cross-reference: NCI:C78787
has cross-reference: SNOMEDCT_US_2020_03_01:423902002
has cross-reference: UMLS_CUI:C0034150
alternative_term: Purpuric disorder
has_obo_namespace: disease_ontology
id: DOID:3326
in subset: NCIthesaurus

benign epilepsy with centrotemporal spikes
type: Class
subclass of: childhood electroclinical syndrome
imported from: doid.owl
has cross-reference: MESH:D019305
has cross-reference: OMIM:117100
has cross-reference: UMLS_CUI:C0376532
alternative_term: BCECTS
alternative_term: benign Rolandic epilepsy
alternative_term: benign childhood epilepsy with centrotemporal spike
alternative_term: rolandic epilepsy
alternative_term: sylvan seizures
has_obo_namespace: disease_ontology
id: DOID:3329

histrionic personality disorder
type: Class
subclass of: personality disorder
textual definition: A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood.
imported from: doid.owl
has cross-reference: ICD10CM:F60.4
has cross-reference: ICD9CM:301.5
has cross-reference: MESH:D006677
has cross-reference: NCI:C92634
has cross-reference: SNOMEDCT_US_2020_03_01:192489002
has cross-reference: UMLS_CUI:C0019681
has_obo_namespace: disease_ontology
id: DOID:334
in subset: NCIthesaurus

osteitis fibrosa
type: Class
subclass of: bone resorption disease
textual definition: A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.
imported from: doid.owl
has cross-reference: MESH:D010002
has cross-reference: NCI:C34875
has cross-reference: SNOMEDCT_US_2020_03_01:190451000
has cross-reference: UMLS_CUI:C0029405
alternative_term: Osteitis fibrosa cystica generalisata
alternative_term: Von Recklinghausen's bone disease
alternative_term: hyperparathyroid bone disease
has_obo_namespace: disease_ontology
id: DOID:3341
in subset: NCIthesaurus

bone inflammation disease
type: Class
subclass of: bone disease
textual definition: A bone disease that results_in inflammation of the located_in bone.
imported from: doid.owl
has cross-reference: MESH:D010000
has cross-reference: SNOMEDCT_US_2020_03_01:274144001
has cross-reference: UMLS_CUI:C0029400
alternative_term: Inflammatory disorder of bone
alternative_term: bone inflammatory disease
alternative_term: osteitis
has_obo_namespace: disease_ontology
id: DOID:3342

glycoproteinosis
type: Class
subclass of: mucolipidosis
textual definition: A mucolipidosis that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase).
imported from: doid.owl
has cross-reference: GARD:10670
has cross-reference: MESH:D009081
has cross-reference: NCI:C61267
has cross-reference: OMIM:256550
has cross-reference: SNOMEDCT_US_2020_03_01:70528007
has cross-reference: UMLS_CUI:C0026697
alternative_term: Mucolipidosis type I
alternative_term: sialidosis
has_obo_namespace: disease_ontology
id: DOID:3343
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping submitted by NeuroDevNet. [LS].

xanthomatosis
type: Class
subclass of: DOID 9455
textual definition: A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts.
imported from: doid.owl
has cross-reference: MESH:D014973
has cross-reference: SNOMEDCT_US_2020_03_01:63103006
has cross-reference: UMLS_CUI:C0043325
alternative_term: xanthelasmatosis
has_obo_namespace: disease_ontology
id: DOID:3345

osteosarcoma
type: Class
subclass of: bone sarcoma
textual definition: A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.
imported from: doid.owl
has_alternative_id: DOID:183
has cross-reference: GARD:7284
has cross-reference: MESH:D012516
has cross-reference: MESH:D018213
has cross-reference: NCI:C9145
has cross-reference: OMIM:259500
has cross-reference: ORDO:668
has cross-reference: SNOMEDCT_US_2020_03_01:189878003
has cross-reference: UMLS_CUI:C0029463
has cross-reference: UMLS_CUI:C0206639
alternative_term: Osteogenic sarcoma
alternative_term: Skeletal sarcoma
alternative_term: bone tissue neoplasm
alternative_term: osteoid sarcoma
has_obo_namespace: disease_ontology
id: DOID:3347
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mesenchymal cell neoplasm
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.
imported from: doid.owl
has_alternative_id: DOID:1630
has cross-reference: NCI:C6587
has cross-reference: NCI:C7059
has cross-reference: UMLS_CUI:C1332517
has cross-reference: UMLS_CUI:C1334699
alternative_term: benign miscellaneous mesenchymal tumor
alternative_term: mesenchymal tumor
has_obo_namespace: disease_ontology
id: DOID:3350
in subset: NCIthesaurus

fibrosarcoma
type: Class
subclass of: connective tissue cancer
textual definition: A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.
imported from: doid.owl
has_alternative_id: DOID:156
has_alternative_id: DOID:3509
has cross-reference: GARD:2327
has cross-reference: MESH:D005354
has cross-reference: MESH:D018218
has cross-reference: NCI:C3043
has cross-reference: NCI:C6605
has cross-reference: NCI:C7075
has cross-reference: SNOMEDCT_US_2020_03_01:443250000
has cross-reference: UMLS_CUI:C0016057
has cross-reference: UMLS_CUI:C0206643
has cross-reference: UMLS_CUI:C1336021
alternative_term: Fibrocytic tumor
alternative_term: fibrosarcoma of soft tissue
alternative_term: fibrous tissue neoplasm
has_obo_namespace: disease_ontology
id: DOID:3355
in subset: NCIthesaurus

localized osteosarcoma
type: Class
subclass of: osteosarcoma
imported from: doid.owl
has cross-reference: NCI:C7780
has cross-reference: UMLS_CUI:C0278511
alternative_term: localised Osteogenic sarcoma
alternative_term: localised osteosarcoma
alternative_term: localized Osteogenic sarcoma
has_obo_namespace: disease_ontology
id: DOID:3356
in subset: NCIthesaurus

coronary aneurysm
type: Class
subclass of: DOID 9768
imported from: doid.owl
has cross-reference: GARD:6200
has cross-reference: ICD10CM:I25.41
has cross-reference: ICD9CM:414.11
has cross-reference: MESH:D003323
has cross-reference: SNOMEDCT_US_2020_03_01:50570003
has cross-reference: UMLS_CUI:C0010051
alternative_term: Aneurysm of coronary vessels
alternative_term: Aneurysmal lesion of coronary artery
alternative_term: Arteriovenous aneurysm of coronary vessels
has_obo_namespace: disease_ontology
id: DOID:3362

Ewing sarcoma
type: Class
subclass of: sarcoma
subclass of: connective tissue cancer
textual definition: A connective tissue cancer that has_material_basis in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.
imported from: doid.owl
has_alternative_id: DOID:0050607
has_alternative_id: DOID:4158
has_alternative_id: DOID:4390
has_alternative_id: DOID:4391
has_alternative_id: DOID:4392
has_alternative_id: DOID:4980
has cross-reference: GARD:6390
has cross-reference: MESH:C563168
has cross-reference: MESH:D012512
has cross-reference: MESH:D018241
has cross-reference: NCI:C27901
has cross-reference: NCI:C27903
has cross-reference: NCI:C4817
has cross-reference: NCI:C7542
has cross-reference: NCI:C7806
has cross-reference: NCI:C9341
has cross-reference: OMIM:612219
has cross-reference: SNOMEDCT_US_2020_03_01:134210007
has cross-reference: SNOMEDCT_US_2020_03_01:73676002
has cross-reference: SNOMEDCT_US_2020_03_01:76909002
has cross-reference: UMLS_CUI:C0553580
has cross-reference: UMLS_CUI:C0684337
has cross-reference: UMLS_CUI:C0796547
has cross-reference: UMLS_CUI:C0863029
has cross-reference: UMLS_CUI:C0877849
has cross-reference: UMLS_CUI:C1334408
alternative_term: Ewing's family localized tumor
alternative_term: Ewing's sarcoma/peripheral primitive neuroectodermal tumor
alternative_term: Ewing's tumor
alternative_term: Ewings sarcoma
alternative_term: Ewings sarcoma-primitive neuroectodermal tumor
alternative_term: PNET of Thoracopulmonary Region
alternative_term: localized Ewing sarcoma
alternative_term: localized Ewing's sarcoma
alternative_term: localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor
alternative_term: localized Ewing's tumor
alternative_term: localized peripheral primitive neuroectodermal tumor
alternative_term: peripheral primitive neuroectodermal tumor
has_obo_namespace: disease_ontology
id: DOID:3369
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chondrosarcoma
type: Class
subclass of: bone sarcoma
textual definition: A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.
imported from: doid.owl
has_alternative_id: DOID:3370
has cross-reference: GARD:6004
has cross-reference: GARD:6055
has cross-reference: MESH:D002813
has cross-reference: NCI:C2946
has cross-reference: NCI:C7155
has cross-reference: OMIM:215300
has cross-reference: SNOMEDCT_US_2020_03_01:443520009
has cross-reference: SNOMEDCT_US_2020_03_01:735679005
has cross-reference: UMLS_CUI:C0008479
has cross-reference: UMLS_CUI:C1335473
alternative_term: Cartilaginous cancer
alternative_term: chondrosarcoma of bone
alternative_term: primary chondrosarcoma of the bone
has_obo_namespace: disease_ontology
id: DOID:3371
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

juxtacortical osteosarcoma
type: Class
subclass of: peripheral osteosarcoma
imported from: doid.owl
has cross-reference: MESH:D018217
has cross-reference: NCI:C8969
has cross-reference: SNOMEDCT_US_2020_03_01:91242000
has cross-reference: UMLS_CUI:C0206642
alternative_term: Parosteal Osteogenic sarcoma
alternative_term: Parosteal Osteosarcoma
has_obo_namespace: disease_ontology
id: DOID:3373
in subset: NCIthesaurus

peripheral osteosarcoma
type: Class
subclass of: bone osteosarcoma
imported from: doid.owl
has cross-reference: NCI:C7134
has cross-reference: UMLS_CUI:C1332591
alternative_term: Surface Osteosarcoma
has_obo_namespace: disease_ontology
id: DOID:3374
in subset: NCIthesaurus

bone osteosarcoma
type: Class
subclass of: osteosarcoma
imported from: doid.owl
has_alternative_id: DOID:8580
has cross-reference: NCI:C53707
has cross-reference: SNOMEDCT_US_2020_03_01:307576001
has cross-reference: UMLS_CUI:C0585442
alternative_term: Osteosarcoma of bone
alternative_term: primary Osteosarcoma of bone
has_obo_namespace: disease_ontology
id: DOID:3376
in subset: DO cancer slim
in subset: NCIthesaurus

small cell osteogenic sarcoma
type: Class
subclass of: conventional central osteosarcoma
imported from: doid.owl
has cross-reference: NCI:C4023
has cross-reference: SNOMEDCT_US_2020_03_01:12302002
has cross-reference: UMLS_CUI:C0279622
alternative_term: Round cell osteosarcoma
alternative_term: small cell Osteosarcoma
has_obo_namespace: disease_ontology
id: DOID:3377
in subset: NCIthesaurus

conventional central osteosarcoma
type: Class
subclass of: bone osteosarcoma
imported from: doid.owl
alternative_term: Medullary Osteosarcoma
alternative_term: Medullary osteosarcoma
alternative_term: conventional Osteosarcoma
has_obo_namespace: disease_ontology
id: DOID:3378

cranial nerve neoplasm
type: Class
subclass of: central nervous system cancer
subclass of: cranial nerve disease
textual definition: A central nervous system cancer develops from schwann cells located_in cranial nerves, has_material_basis_in abnormally proliferating cells.
imported from: doid.owl
has cross-reference: MESH:D003390
has cross-reference: NCI:C2963
has cross-reference: SNOMEDCT_US_2020_03_01:126966009
has cross-reference: UMLS_CUI:C0010267
alternative_term: neoplasm of cranial nerve
has_obo_namespace: disease_ontology
id: DOID:338
in subset: NCIthesaurus

liposarcoma
type: Class
subclass of: lipomatous cancer
textual definition: A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum and the extremities.
imported from: doid.owl
has cross-reference: GARD:6913
has cross-reference: MESH:D008080
has cross-reference: NCI:C3194
has cross-reference: SNOMEDCT_US_2020_03_01:254829001
has cross-reference: UMLS_CUI:C0023827
has_obo_namespace: disease_ontology
id: DOID:3382
in subset: DO cancer slim
in subset: NCIthesaurus

bacterial vaginosis
type: Class
subclass of: bacterial infectious disease
subclass of: vaginitis
textual definition: A vaginitis that is characterized by a grayish vaginal discharge usually of foul odor and the presence of Gardnerella vaginalis.
imported from: doid.owl
has cross-reference: MESH:D016585
has cross-reference: NCI:C116973
has cross-reference: SNOMEDCT_US_2020_03_01:237092002
has cross-reference: UMLS_CUI:C0085166
has_obo_namespace: disease_ontology
id: DOID:3385
in subset: NCIthesaurus

periodontal disease
type: Class
subclass of: mouth disease
textual definition: A mouth disease that is relating to or affecting the structures surrounding and supporting the teeth.
imported from: doid.owl
has cross-reference: ICD10CM:K05.6
has cross-reference: MESH:D010510
has cross-reference: NCI:C63743
has cross-reference: SNOMEDCT_US_2020_03_01:196354003
has cross-reference: UMLS_CUI:C0031090
alternative_term: Periodontal disease
alternative_term: disease of supporting structures of teeth
alternative_term: periodontium disorder
has_obo_namespace: disease_ontology
id: DOID:3388
in subset: NCIthesaurus

Papillon-Lefevre disease
type: Class
subclass of: autosomal recessive disease
subclass of: tooth disease
subclass of: ectodermal dysplasia
textual definition: An ectodermal dysplasia that is characterized by palmoplantar keratoderma associated with early-onset periodontitis and has_material_basis_in homozygous or compound heterozygous mutation in the cathepsin C gene on chromosome 11q14.
imported from: doid.owl
has cross-reference: GARD:3100
has cross-reference: MESH:D010214
has cross-reference: NCI:C84992
has cross-reference: OMIM:245000
has cross-reference: ORDO:678
has cross-reference: SNOMEDCT_US_2020_03_01:40158001
has cross-reference: UMLS_CUI:C0030360
alternative_term: Papillon Lefevre syndrome
alternative_term: Papillon-Lefvre syndrome
has_obo_namespace: disease_ontology
id: DOID:3389
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

palmoplantar keratosis
type: Class
subclass of: keratosis
textual definition: A keratosis characterized by abnormal thickening of the palms and the soles.
imported from: doid.owl
has cross-reference: GARD:8167
has cross-reference: ICD10CM:L85.2
has cross-reference: SNOMEDCT_US_2020_03_01:28596004
has cross-reference: UMLS_CUI:C0022596
alternative_term: Keratosis palmaris et plantaris @fr
alternative_term: Palmoplantar Keratoderma
alternative_term: palmo-plantar keratodermas
has_obo_namespace: disease_ontology
id: DOID:3390
in subset: NCIthesaurus

coronary artery disease
type: Class
subclass of: artery disease
textual definition: An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.
imported from: doid.owl
has_alternative_id: DOID:10506
has_alternative_id: DOID:3363
has_alternative_id: DOID:3394
has_alternative_id: DOID:9420
has cross-reference: EFO:0001645
has cross-reference: ICD10CM:I20-I25
has cross-reference: ICD10CM:I25
has cross-reference: ICD10CM:I25.1
has cross-reference: ICD10CM:I25.10
has cross-reference: ICD9CM:410-414.99
has cross-reference: ICD9CM:414.0
has cross-reference: ICD9CM:414.9
has cross-reference: MESH:D003324
has cross-reference: MESH:D003327
has cross-reference: MESH:D017202
has cross-reference: NCI:C35505
has cross-reference: NCI:C50625
has cross-reference: OMIM:300464
has cross-reference: OMIM:607339
has cross-reference: OMIM:608316
has cross-reference: OMIM:608318
has cross-reference: OMIM:608320
has cross-reference: OMIM:610947
has cross-reference: OMIM:611139
has cross-reference: OMIM:612030
has cross-reference: OMIM:614293
has cross-reference: SNOMEDCT_US_2020_03_01:194852007
has cross-reference: SNOMEDCT_US_2020_03_01:233822007
has cross-reference: SNOMEDCT_US_2020_03_01:41702007
has cross-reference: SNOMEDCT_US_2020_03_01:53741008
has cross-reference: UMLS_CUI:C0010054
has cross-reference: UMLS_CUI:C0010068
has cross-reference: UMLS_CUI:C0151744
has cross-reference: UMLS_CUI:C0264694
alternative_term: CHD
alternative_term: Coronary disease
alternative_term: coronary arteriosclerosis
alternative_term: coronary heart disease
has_obo_namespace: disease_ontology
id: DOID:3393
in subset: NCIthesaurus
comment: Xref MGI.

inappropriate ADH syndrome
type: Class
subclass of: pituitary gland disease
imported from: doid.owl
has cross-reference: ICD10CM:E22.2
has cross-reference: MESH:D007177
has cross-reference: NCI:C3988
has cross-reference: SNOMEDCT_US_2020_03_01:55004003
has cross-reference: UMLS_CUI:C0021141
alternative_term: syndrome of Inappropriate Antidiuretic Hormone Secretion
alternative_term: syndrome of inappropriate secretion of ADH
alternative_term: syndrome of inappropriate secretion of antidiuretic hormone
alternative_term: syndrome of inappropriate vasopressin secretion
has_obo_namespace: disease_ontology
id: DOID:3401
in subset: NCIthesaurus

histiocytosis
type: Class
subclass of: lymphatic system disease
textual definition: A lymphatic system disease that is characterized by an excessive number of histiocytes.
imported from: doid.owl
has_alternative_id: DOID:3344
has cross-reference: MESH:D015614
has cross-reference: NCI:C3106
has cross-reference: SNOMEDCT_US_2020_03_01:60657004
has cross-reference: UMLS_CUI:C0019618
alternative_term: Hand Schuller Christian disease
alternative_term: chronic Histiocytosis X
has_obo_namespace: disease_ontology
id: DOID:3405
in subset: NCIthesaurus

carotid artery disease
type: Class
subclass of: artery disease
subclass of: cerebrovascular disease
imported from: doid.owl
has cross-reference: MESH:D002340
has cross-reference: NCI:C84476
has cross-reference: SNOMEDCT_US_2020_03_01:371160000
has cross-reference: UMLS_CUI:C0007273
alternative_term: disorder of carotid artery
has_obo_namespace: disease_ontology
id: DOID:3407
in subset: NCIthesaurus

peripheral vascular disease
type: Class
subclass of: vascular disease
textual definition: A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.
imported from: doid.owl
has_alternative_id: DOID:2868
has cross-reference: ICD9CM:443.81
has cross-reference: MESH:D001157
has cross-reference: SNOMEDCT_US_2020_03_01:195624006
has cross-reference: SNOMEDCT_US_2020_03_01:2929001
has cross-reference: UMLS_CUI:C0003838
has cross-reference: UMLS_CUI:C0031115
alternative_term: arterial occlusive disease
has_obo_namespace: disease_ontology
id: DOID:341

alpha-mannosidosis
type: Class
subclass of: lysosomal storage disease
textual definition: A lysosomal storage disease that has_material_basis_in deficiency of the alpha-D-manosidase enzyme resulting in the impairment of cell function from a build up of complex sugars derived from glycoproteins in the lysosome.
imported from: doid.owl
has cross-reference: GARD:6968
has cross-reference: MESH:D008363
has cross-reference: NCI:C84548
has cross-reference: OMIM:248500
has cross-reference: SNOMEDCT_US_2020_03_01:65524005
has cross-reference: UMLS_CUI:C0024748
alternative_term: Alpha-D-mannosidosis
alternative_term: alpha-mannosidase deficiency
alternative_term: deficiency of alpha-mannosidase
has_obo_namespace: disease_ontology
id: DOID:3413
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

glossopharyngeal nerve disease
type: Class
subclass of: cranial nerve disease
textual definition: A cranial nerve disease that is located_in the ninth cranial nerve or its nuclei in the medulla.
imported from: doid.owl
has cross-reference: ICD10CM:G52
has cross-reference: ICD9CM:352
has cross-reference: SNOMEDCT_US_2020_03_01:193098000
has cross-reference: UMLS_CUI:C0154730
alternative_term: ninth cranial nerve disease
has_obo_namespace: disease_ontology
id: DOID:3418

optic nerve neoplasm
type: Class
subclass of: optic nerve disease
subclass of: cranial nerve neoplasm
imported from: doid.owl
has cross-reference: MESH:D019574
has cross-reference: NCI:C4801
has cross-reference: SNOMEDCT_US_2020_03_01:126968005
has cross-reference: UMLS_CUI:C0524802
alternative_term: Tumour of optic nerve
alternative_term: neoplasm of optic nerve
alternative_term: tumor of Second Cranial nerve
has_obo_namespace: disease_ontology
id: DOID:3419
in subset: NCIthesaurus

subclavian artery aneurysm
type: Class
subclass of: artery disease
imported from: doid.owl
has cross-reference: ICD9CM:442.82
has cross-reference: SNOMEDCT_US_2020_03_01:40136003
has cross-reference: UMLS_CUI:C0155746
has_obo_namespace: disease_ontology
id: DOID:342

vestibular disease
type: Class
subclass of: inner ear disease
imported from: doid.owl
has cross-reference: ICD10CM:H81.9
has cross-reference: MESH:D015837
has cross-reference: SNOMEDCT_US_2020_03_01:20425006
has cross-reference: UMLS_CUI:C0042594
alternative_term: Vertigo, vestibular disorder
has_obo_namespace: disease_ontology
id: DOID:3426

inclusion body myositis
type: Class
subclass of: myositis
textual definition: A myositis that is characterized by late onset of skeletal muscle inflammation, weakness, and atrophy with cytoplasmic granules and vacuoles in the muscle.
imported from: doid.owl
has cross-reference: GARD:3896
has cross-reference: ICD10CM:G72.41
has cross-reference: ICD9CM:359.71
has cross-reference: MESH:D018979
has cross-reference: NCI:C84786
has cross-reference: OMIM:147421
has cross-reference: ORDO:611
has cross-reference: SNOMEDCT_US_2020_03_01:72315009
has cross-reference: UMLS_CUI:C0238190
has_obo_namespace: disease_ontology
id: DOID:3429
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

laryngitis
type: Class
subclass of: laryngeal disease
textual definition: A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.
imported from: doid.owl
has cross-reference: MESH:D007827
has cross-reference: NCI:C26811
has cross-reference: SNOMEDCT_US_2020_03_01:45913009
has cross-reference: UMLS_CUI:C0023067
has_obo_namespace: disease_ontology
id: DOID:3437
in subset: NCIthesaurus

mammary Paget's disease
type: Class
subclass of: breast adenocarcinoma
textual definition: A breast adenocarcinoma that has_material_basis_in epidermal Paget cells, which are malignant glandular epithelial cells with abundant and clear cytoplasm, usually containing mucin, and pleomorphic and hyperchromatic nucleus.
imported from: doid.owl
has cross-reference: NCI:C7073
has cross-reference: UMLS_CUI:C1368019
alternative_term: Paget cell neoplasm
alternative_term: Paget's disease
alternative_term: Paget's disease of the breast
alternative_term: mammary Paget disease
has_obo_namespace: disease_ontology
id: DOID:3443
in subset: NCIthesaurus

anal Paget's disease
type: Class
subclass of: anus adenocarcinoma
imported from: doid.owl
has cross-reference: NCI:C5598
has cross-reference: UMLS_CUI:C1332274
alternative_term: Paget's disease of anus
alternative_term: anal Paget disease
has_obo_namespace: disease_ontology
has_related_synonym: Paget's disease of the anus
id: DOID:3446
in subset: NCIthesaurus

anus adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: anal carcinoma
textual definition: An anal carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C5600
has cross-reference: SNOMEDCT_US_2020_03_01:423607006
has cross-reference: UMLS_CUI:C1332257
alternative_term: adenocarcinoma of anus
has_obo_namespace: disease_ontology
has_related_synonym: adenocarcinoma of the anus
id: DOID:3447
in subset: DO cancer slim
in subset: NCIthesaurus

penis carcinoma
type: Class
subclass of: penile cancer
subclass of: carcinoma
textual definition: A penile cancer that is located_in the skin or tissues of the penis.
imported from: doid.owl
has cross-reference: NCI:C9061
has cross-reference: SNOMEDCT_US_2020_03_01:372106005
has cross-reference: UMLS_CUI:C0853105
alternative_term: Penile carcinoma
alternative_term: carcinoma of penis
has_obo_namespace: disease_ontology
id: DOID:3449
in subset: DO cancer slim
in subset: NCIthesaurus

uterine disease
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is located_in the uterus.
imported from: doid.owl
has cross-reference: ICD10CM:N85.9
has cross-reference: ICD9CM:621.9
has cross-reference: MESH:D014591
has cross-reference: NCI:C26907
has cross-reference: SNOMEDCT_US_2020_03_01:237068005
has cross-reference: UMLS_CUI:C0042131
has_obo_namespace: disease_ontology
id: DOID:345
in subset: NCIthesaurus

skin carcinoma
type: Class
subclass of: carcinoma
subclass of: skin cancer
textual definition: A skin cancer that is located_in tissues of the skin and develops from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C4914
has cross-reference: UMLS_CUI:C0699893
alternative_term: carcinoma of skin
has_obo_namespace: disease_ontology
id: DOID:3451
in subset: NCIthesaurus

brain infarction
type: Class
subclass of: cerebrovascular disease
textual definition: A cerebrovascular disease that is characterized by tissue necrosis located_in the brain, resulting from inadequate blood flow through the brain.
imported from: doid.owl
has cross-reference: MESH:D020520
has cross-reference: UMLS_CUI:C0751955
has_obo_namespace: disease_ontology
id: DOID:3454

invasive lobular carcinoma
type: Class
subclass of: breast lobular carcinoma
textual definition: A breast lobular carcinoma that is characterized by infiltration into the tissue of the breast outside of the lobule where it originated.
imported from: doid.owl
has cross-reference: MESH:D018275
has cross-reference: NCI:C3771
has cross-reference: SNOMEDCT_US_2020_03_01:89740008
has cross-reference: UMLS_CUI:C0206692
alternative_term: Lobular carcinoma
alternative_term: Lobular carcinoma of breast
alternative_term: Lobular carcinoma of the breast
has_obo_namespace: disease_ontology
id: DOID:3457
in subset: NCIthesaurus

breast adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: breast carcinoma
textual definition: A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.
imported from: doid.owl
has cross-reference: NCI:C5214
has cross-reference: UMLS_CUI:C0858252
alternative_term: Mammary adenocarcinoma
has_obo_namespace: disease_ontology
has_related_synonym: adenocarcinoma of breast
id: DOID:3458
in subset: NCIthesaurus

breast carcinoma
type: Class
subclass of: breast cancer
textual definition: A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: EFO:0000305
has cross-reference: MESH:D001943
has cross-reference: NCI:C4872
has cross-reference: SNOMEDCT_US_2020_03_01:154513000
has cross-reference: UMLS_CUI:C0678222
alternative_term: Mammary carcinoma
alternative_term: carcinoma of breast
has_obo_namespace: disease_ontology
id: DOID:3459
in subset: DO cancer slim
in subset: NCIthesaurus

breast disease
type: Class
subclass of: thoracic disease
textual definition: A thoracic disease that is located_in the breast.
imported from: doid.owl
has cross-reference: ICD10CM:N64.9
has cross-reference: ICD9CM:610-612.99
has cross-reference: MESH:D001941
has cross-reference: NCI:C26709
has cross-reference: SNOMEDCT_US_2020_03_01:79604008
has cross-reference: UMLS_CUI:C0006145
has_obo_namespace: disease_ontology
id: DOID:3463
in subset: NCIthesaurus

uveal cancer
type: Class
subclass of: ocular cancer
subclass of: uveal disease
textual definition: An ocular cancer that is located_in the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid. The uvea is the most common location of intraocular malignancy in adults and may commonly be caused by a subtype of cancer that arises from melanocytes.
imported from: doid.owl
has_alternative_id: DOID:12754
has cross-reference: MESH:D014604
has cross-reference: NCI:C3436
has cross-reference: NCI:C6105
has cross-reference: UMLS_CUI:C0042162
has cross-reference: UMLS_CUI:C1334629
alternative_term: Uveal tumor
alternative_term: malignant Uveal tumor
alternative_term: malignant uvea neoplasm
has_obo_namespace: disease_ontology
id: DOID:3479
in subset: NCIthesaurus

blepharochalasis
type: Class
subclass of: eyelid disease
textual definition: An eyelid disease that is characterized by exacerbations and remissions of eyelid edema, which results in a stretching and subsequent atrophy of the eyelid tissue, leading to the formation of redundant folds over the lid margins.
imported from: doid.owl
has cross-reference: ICD10CM:H02.3
has cross-reference: ICD9CM:374.34
has cross-reference: SNOMEDCT_US_2020_03_01:193944001
has cross-reference: UMLS_CUI:C0005742
has_obo_namespace: disease_ontology
id: DOID:348

uveal disease
type: Class
subclass of: eye disease
textual definition: An eye disease affecting the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid.
imported from: doid.owl
has cross-reference: GARD:8192
has cross-reference: MESH:D014603
has cross-reference: NCI:C26908
has cross-reference: SNOMEDCT_US_2020_03_01:95678007
has cross-reference: UMLS_CUI:C0042161
has_obo_namespace: disease_ontology
id: DOID:3480
in subset: NCIthesaurus

plague
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.
imported from: doid.owl
has cross-reference: ICD10CM:A20
has cross-reference: ICD9CM:020
has cross-reference: MESH:D010930
has cross-reference: NCI:C85015
has cross-reference: SNOMEDCT_US_2020_03_01:58750007
has cross-reference: UMLS_CUI:C0032064
has_obo_namespace: disease_ontology
id: DOID:3482
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

systemic mastocytosis
type: Class
subclass of: mastocytosis
imported from: doid.owl
has cross-reference: GARD:8616
has cross-reference: ICD10CM:D47.02
has cross-reference: MESH:D034721
has cross-reference: NCI:C9235
has cross-reference: SNOMEDCT_US_2020_03_01:123310005
has cross-reference: UMLS_CUI:C0221013
alternative_term: SMCD - systemic mast cell disease
alternative_term: systemic tissue mast cell disease
has_obo_namespace: disease_ontology
id: DOID:349
in subset: NCIthesaurus

Noonan syndrome
type: Class
subclass of: monogenic disease
subclass of: RASopathy
textual definition: A RASopathy that is characterized by mildly unusual facial features, short stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms.
imported from: doid.owl
has cross-reference: GARD:10955
has cross-reference: ICD10CM:Q87.19
has cross-reference: MESH:D009634
has cross-reference: NCI:C34854
has cross-reference: OMIM:PS163950
has cross-reference: ORDO:648
has cross-reference: SNOMEDCT_US_2020_03_01:88327006
has cross-reference: UMLS_CUI:C0028326
alternative_term: Turner's phenotype, karyotype normal
has_obo_namespace: disease_ontology
id: DOID:3490
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Turner syndrome
type: Class
subclass of: gonadal dysgenesis
textual definition: A gonadal dysgenesis that is characterized by short stature and early loss of ovarian function resulting from ovarian hypofunction or premature ovarian failure and has_material_basis_in one missing or structurally altered X chromosome.
imported from: doid.owl
has_alternative_id: DOID:5448
has cross-reference: GARD:2540
has cross-reference: GARD:7831
has cross-reference: ICD10CM:Q96
has cross-reference: MESH:D014424
has cross-reference: NCI:C26900
has cross-reference: NCI:C34434
has cross-reference: SNOMEDCT_US_2020_03_01:38804009
has cross-reference: UMLS_CUI:C0041408
has cross-reference: UMLS_CUI:C1527168
alternative_term: Bonnevie-Ullrich syndrome
alternative_term: Gonadal dysgenesis - Turner
alternative_term: Karyotype 45, X
alternative_term: Monosomy X
alternative_term: XO syndrome
alternative_term: monosomy X syndrome
has_obo_namespace: disease_ontology
id: DOID:3491
in subset: DO rare slim
in subset: NCIthesaurus
comment: No OMIM mapping, confirmed by DO. [LS].

mixed connective tissue disease
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: DOID 854
textual definition: A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen.
imported from: doid.owl
has cross-reference: GARD:7051
has cross-reference: ICD10CM:M35.1
has cross-reference: MESH:D008947
has cross-reference: NCI:C84892
has cross-reference: SNOMEDCT_US_2020_03_01:33110008
has cross-reference: UMLS_CUI:C0026272
alternative_term: Connective tissue disease overlap syndrome
alternative_term: mixed collagen vascular disease
has_obo_namespace: disease_ontology
id: DOID:3492
in subset: NCIthesaurus

signet ring cell adenocarcinoma
type: Class
subclass of: adenocarcinoma
textual definition: An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance.
imported from: doid.owl
has cross-reference: MESH:D018279
has cross-reference: NCI:C3774
has cross-reference: SNOMEDCT_US_2020_03_01:189701002
has cross-reference: UMLS_CUI:C0206696
alternative_term: Signet Ring cell adenocarcinoma
alternative_term: Signet ring carcinoma
alternative_term: Signet ring cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:3493
in subset: NCIthesaurus

pancreatic ductal adenocarcinoma
type: Class
subclass of: pancreatic adenocarcinoma
textual definition: A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
imported from: doid.owl
has cross-reference: NCI:C9120
has cross-reference: SNOMEDCT_US_2020_03_01:792907004
has cross-reference: UMLS_CUI:C1335302
alternative_term: ductal adenocarcinoma of the pancreas
has_obo_namespace: disease_ontology
id: DOID:3498
in subset: DO cancer slim
in subset: NCIthesaurus

mastocytosis
type: Class
subclass of: DOID 9500
imported from: doid.owl
has cross-reference: GARD:6987
has cross-reference: ICD10CM:D47.09
has cross-reference: MESH:D008415
has cross-reference: NCI:C84269
has cross-reference: OMIM:154800
has cross-reference: SNOMEDCT_US_2020_03_01:78745000
has cross-reference: UMLS_CUI:C0024899
alternative_term: mast cell hyperplasia
has_obo_namespace: disease_ontology
id: DOID:350
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

dermatofibrosarcoma protuberans
type: Class
subclass of: fibrosarcoma
textual definition: A fibrosarcoma that is located_in the dermis laryer of the skin and that begins as a hard nodule and grows slowly.
imported from: doid.owl
has cross-reference: GARD:9569
has cross-reference: MESH:D018223
has cross-reference: OMIM:607907
has cross-reference: SNOMEDCT_US_2020_03_01:302844005
has cross-reference: UMLS_CUI:C0206647
has_obo_namespace: disease_ontology
id: DOID:3507
in subset: DO cancer slim
comment: MESH:C538219 added from NeuroDevNet [WAK].

neurofibrosarcoma
type: Class
subclass of: DOID 962
imported from: doid.owl
has cross-reference: GARD:8211
has cross-reference: MESH:D018319
has cross-reference: SNOMEDCT_US_2020_03_01:19897006
has cross-reference: UMLS_CUI:C0206729
alternative_term: Neurosarcoma
has_obo_namespace: disease_ontology
id: DOID:3512

pediatric fibrosarcoma
type: Class
subclass of: fibrosarcoma
imported from: doid.owl
has cross-reference: NCI:C8088
has cross-reference: UMLS_CUI:C0279981
has_obo_namespace: disease_ontology
id: DOID:3520
in subset: DO cancer slim
in subset: NCIthesaurus

middle cerebral artery infarction
type: Class
subclass of: cerebral infarction
imported from: doid.owl
has cross-reference: MESH:D020244
has cross-reference: UMLS_CUI:C0740392
has_obo_namespace: disease_ontology
id: DOID:3525

cerebral infarction
type: Class
subclass of: brain infarction
textual definition: A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain.
imported from: doid.owl
has cross-reference: ICD10CM:I63
has cross-reference: MESH:D002544
has cross-reference: NCI:C50486
has cross-reference: OMIM:601367
has cross-reference: SNOMEDCT_US_2020_03_01:195188006
has cross-reference: UMLS_CUI:C0007785
alternative_term: CVA - Cerebral infarction
alternative_term: Cerebral infarct
alternative_term: Cerebral infarction
has_obo_namespace: disease_ontology
id: DOID:3526
in subset: NCIthesaurus

cerebral arterial disease
type: Class
subclass of: artery disease
subclass of: intracranial arterial disease
imported from: doid.owl
has cross-reference: MESH:D002539
has cross-reference: UMLS_CUI:C0007774
has_obo_namespace: disease_ontology
id: DOID:3527

central core myopathy
type: Class
subclass of: congenital structural myopathy
imported from: doid.owl
has cross-reference: ICD10CM:G71.2
has cross-reference: MESH:D020512
has cross-reference: NCI:C83010
has cross-reference: OMIM:117000
has cross-reference: SNOMEDCT_US_2020_03_01:43152001
has cross-reference: UMLS_CUI:C0751951
alternative_term: central core disease
has_obo_namespace: disease_ontology
id: DOID:3529
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

chronic wasting disease
type: Class
subclass of: prion disease
imported from: doid.owl
has cross-reference: MESH:D034081
has cross-reference: UMLS_CUI:C1135993
has_obo_namespace: disease_ontology
id: DOID:3530

Unverricht-Lundborg syndrome
type: Class
subclass of: DOID 891
textual definition: A progressive myoclonus epilepsy characterized by onset between 6 and 13 years of age of action- and stimulus-sensitive myoclonus, tonic-clonic seizures with ataxia, and a mild cognitive decline.
imported from: doid.owl
has cross-reference: GARD:3876
has cross-reference: MESH:D020194
has cross-reference: SNOMEDCT_US_2020_03_01:192847001
has cross-reference: UMLS_CUI:C0751785
alternative_term: Unverricht - Lundborg disease
alternative_term: Unverricht's disease
alternative_term: Unverricht-Lundborg disease
has_obo_namespace: disease_ontology
id: DOID:3535
comment: OMIM mapping confirmed by DO. [LS].

choroid plexus cancer
type: Class
subclass of: cerebral ventricle cancer
textual definition: A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain.
imported from: doid.owl
has cross-reference: MESH:D016545
has cross-reference: NCI:C3473
has cross-reference: SNOMEDCT_US_2020_03_01:254942002
has cross-reference: UMLS_CUI:C0085138
alternative_term: tumor of choroid plexus
alternative_term: tumor of the Choroid Plexus
has_obo_namespace: disease_ontology
has_related_synonym: choroid plexus neoplasm
id: DOID:3540
in subset: NCIthesaurus

cerebral ventricle cancer
type: Class
subclass of: cerebrum cancer
textual definition: A cerebrum cancer that is located_in the cerebral ventricles.
imported from: doid.owl
has_alternative_id: DOID:10856
has cross-reference: GARD:6025
has cross-reference: ICD10CM:C71.5
has cross-reference: ICD9CM:191.5
has cross-reference: MESH:D002551
has cross-reference: NCI:C2937
has cross-reference: SNOMEDCT_US_2020_03_01:126958000
has cross-reference: SNOMEDCT_US_2020_03_01:363471001
has cross-reference: UMLS_CUI:C0007798
has cross-reference: UMLS_CUI:C0346906
alternative_term: Intraventricular tumor of brain
alternative_term: cerebral ventricle neoplasm
has_obo_namespace: disease_ontology
id: DOID:3541
in subset: NCIthesaurus

mast-cell sarcoma
type: Class
subclass of: sarcoma
subclass of: mast cell neoplasm
textual definition: A sarcoma that has_material_basis in mast cells.
imported from: doid.owl
has cross-reference: ICD10CM:C96.22
has cross-reference: ICD9CM:202.6
has cross-reference: MESH:D012515
has cross-reference: NCI:C9348
has cross-reference: SNOMEDCT_US_2020_03_01:118615008
has cross-reference: UMLS_CUI:C0036221
has_obo_namespace: disease_ontology
id: DOID:355
in subset: NCIthesaurus

superior mesenteric artery syndrome
type: Class
subclass of: duodenal obstruction
imported from: doid.owl
has cross-reference: GARD:7712
has cross-reference: MESH:D013478
has cross-reference: NCI:C85175
has cross-reference: SNOMEDCT_US_2020_03_01:24988007
has cross-reference: UMLS_CUI:C0038828
alternative_term: Superior mesenteric artery syndrome
has_obo_namespace: disease_ontology
id: DOID:3557
in subset: NCIthesaurus

duodenal obstruction
type: Class
subclass of: duodenum disease
imported from: doid.owl
has cross-reference: ICD10CM:K31.5
has cross-reference: MESH:D004380
has cross-reference: NCI:C79548
has cross-reference: SNOMEDCT_US_2020_03_01:95532008
has cross-reference: UMLS_CUI:C0013292
has_obo_namespace: disease_ontology
id: DOID:3558
in subset: NCIthesaurus

pseudomyxoma peritonei
type: Class
subclass of: appendix cancer
textual definition: An appendix cancer that is characterized by progressive accumulation of mucus-secreting tumor cells within the abdomen and pelvis.
imported from: doid.owl
has cross-reference: GARD:7488
has cross-reference: MESH:D011553
has cross-reference: NCI:C3345
has cross-reference: SNOMEDCT_US_2020_03_01:307601000
has cross-reference: UMLS_CUI:C0033822
alternative_term: Pseudomyxoma peritonei
alternative_term: mucinous Ascites
has_obo_namespace: disease_ontology
id: DOID:3559
in subset: DO cancer slim
in subset: NCIthesaurus

meningioma
type: Class
subclass of: central nervous system cancer
textual definition: A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid cap cells of the arachnoid villi in the meninges.
imported from: doid.owl
has_alternative_id: DOID:1137
has_alternative_id: DOID:3554
has_alternative_id: DOID:3567
has_alternative_id: DOID:4750
has cross-reference: GARD:7015
has cross-reference: ICD10CM:D32.9
has cross-reference: ICDO:M9530/3
has cross-reference: MESH:D008577
has cross-reference: MESH:D008579
has cross-reference: NCI:C3229
has cross-reference: NCI:C3230
has cross-reference: NCI:C4656
has cross-reference: NCI:C6971
has cross-reference: NCI:C7048
has cross-reference: SNOMEDCT_US_2020_03_01:127579001
has cross-reference: SNOMEDCT_US_2020_03_01:269643009
has cross-reference: SNOMEDCT_US_2020_03_01:302820008
has cross-reference: UMLS_CUI:C0025284
has cross-reference: UMLS_CUI:C0025286
has cross-reference: UMLS_CUI:C0349604
has cross-reference: UMLS_CUI:C1334698
has cross-reference: UMLS_CUI:C1336537
alternative_term: intracranial meningioma
alternative_term: meningeal neoplasm
alternative_term: meningothelial cell tumor
alternative_term: neoplasm of the meninges
alternative_term: primary Meningeal tumor
alternative_term: supratentorial meningioma
has_obo_namespace: disease_ontology
id: DOID:3565
in subset: DO cancer slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

liver cancer
type: Class
subclass of: hepatobiliary system cancer
subclass of: endocrine gland cancer
subclass of: liver disease
textual definition: A hepatobiliary system cancer that is located_in the liver.
imported from: doid.owl
has_alternative_id: DOID:12300
has_alternative_id: DOID:269
has_alternative_id: DOID:7330
has_alternative_id: DOID:915
has_alternative_id: DOID:919
has cross-reference: ICD10CM:C22.0
has cross-reference: ICD10CM:C22.9
has cross-reference: ICD9CM:155.0
has cross-reference: ICD9CM:155.2
has cross-reference: MESH:D008113
has cross-reference: NCI:C34803
has cross-reference: NCI:C7692
has cross-reference: SNOMEDCT_US_2020_03_01:126851005
has cross-reference: SNOMEDCT_US_2020_03_01:187771009
has cross-reference: SNOMEDCT_US_2020_03_01:93870000
has cross-reference: UMLS_CUI:C0023903
has cross-reference: UMLS_CUI:C0024620
has cross-reference: UMLS_CUI:C0345904
has cross-reference: UMLS_CUI:C0854795
alternative_term: Ca liver - primary
alternative_term: Resectable malignant neoplasm of Liver
alternative_term: ca liver - primary
alternative_term: hepatic cancer
alternative_term: hepatic neoplasm
alternative_term: malignant hepato-biliary neoplasm
alternative_term: malignant neoplasm of liver
alternative_term: malignant neoplasm of liver, not specified as primary or secondary
alternative_term: malignant neoplasm of liver, primary
alternative_term: malignant tumor of liver
alternative_term: neoplasm of liver
alternative_term: non-resectable primary hepatic malignant neoplasm
alternative_term: primary liver cancer
alternative_term: primary malignant neoplasm of Liver
alternative_term: primary malignant neoplasm of liver
alternative_term: resectable malignant neoplasm of the liver
has_obo_namespace: disease_ontology
id: DOID:3571
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

intracranial sinus thrombosis
type: Class
subclass of: intracranial thrombosis
imported from: doid.owl
has cross-reference: MESH:D012851
has cross-reference: UMLS_CUI:C0037198
has_obo_namespace: disease_ontology
id: DOID:3572

lateral sinus thrombosis
type: Class
subclass of: intracranial sinus thrombosis
imported from: doid.owl
has cross-reference: MESH:D020227
has cross-reference: SNOMEDCT_US_2020_03_01:21258007
has cross-reference: UMLS_CUI:C0270639
alternative_term: Thrombosis of lateral venous sinus
alternative_term: Thrombosis transverse sinus
has_obo_namespace: disease_ontology
id: DOID:3574

sagittal sinus thrombosis
type: Class
subclass of: intracranial sinus thrombosis
imported from: doid.owl
has cross-reference: MESH:D020225
has cross-reference: SNOMEDCT_US_2020_03_01:70607008
has cross-reference: UMLS_CUI:C0338575
alternative_term: Thrombosis of superior longitudinal sinus
alternative_term: Thrombosis of superior sagittal sinus
has_obo_namespace: disease_ontology
id: DOID:3576

Sertoli cell tumor
type: Class
subclass of: sex cord-gonadal stromal tumor
textual definition: A sex cord-gonadal stromal tumor characterized by excessive proliferation of Sertoli cells.
imported from: doid.owl
has_alternative_id: DOID:0050617
has cross-reference: MESH:D012707
has cross-reference: NCI:C39976
has cross-reference: SNOMEDCT_US_2020_03_01:89089007
has cross-reference: UMLS_CUI:C0036769
alternative_term: tubular androblastoma
has_obo_namespace: disease_ontology
id: DOID:3577
in subset: NCIthesaurus

testicular gonadoblastoma
type: Class
subclass of: male reproductive organ benign neoplasm
subclass of: testicular disease
subclass of: gonadoblastoma
imported from: doid.owl
has cross-reference: NCI:C39911
has cross-reference: UMLS_CUI:C1515283
has_obo_namespace: disease_ontology
id: DOID:3579
in subset: NCIthesaurus

gestational trophoblastic neoplasm
type: Class
subclass of: endometrial cancer
subclass of: trophoblastic neoplasm
imported from: doid.owl
has_alternative_id: DOID:14071
has_alternative_id: DOID:3598
has cross-reference: ICD10CM:O01
has cross-reference: ICD9CM:630
has cross-reference: MESH:D006828
has cross-reference: MESH:D031901
has cross-reference: NCI:C3110
has cross-reference: NCI:C4699
has cross-reference: NCI:C7887
has cross-reference: OMIM:231090
has cross-reference: SNOMEDCT_US_2020_03_01:156085008
has cross-reference: SNOMEDCT_US_2020_03_01:417475006
has cross-reference: UMLS_CUI:C0020217
has cross-reference: UMLS_CUI:C0278796
has cross-reference: UMLS_CUI:C1135868
alternative_term: gestational trophoblastic neoplasia
alternative_term: hydatidiform mole
alternative_term: molar pregnancy
has_obo_namespace: disease_ontology
id: DOID:3590
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

epithelioid trophoblastic tumor
type: Class
subclass of: lung cancer
subclass of: trophoblastic neoplasm
subclass of: cervical cancer
imported from: doid.owl
has cross-reference: NCI:C6900
has cross-reference: SNOMEDCT_US_2020_03_01:128767001
has cross-reference: UMLS_CUI:C1266159
has_obo_namespace: disease_ontology
id: DOID:3593
in subset: NCIthesaurus

choriocarcinoma
type: Class
subclass of: placenta cancer
textual definition: A placenta cancer that has_material_basis_in trophoblastic cells.
imported from: doid.owl
has cross-reference: GARD:6059
has cross-reference: ICD10CM:C58
has cross-reference: MESH:D002822
has cross-reference: NCI:C2948
has cross-reference: SNOMEDCT_US_2020_03_01:189444004
has cross-reference: UMLS_CUI:C0008497
alternative_term: Chorioepithelioma
has_obo_namespace: disease_ontology
id: DOID:3594
in subset: NCIthesaurus

placental site trophoblastic tumor
type: Class
subclass of: choriocarcinoma
textual definition: A choriocarcinoma that is characterized by low beta-hCG levels and arises from neoplastic transformation of intermediate trophoblastic cells.
imported from: doid.owl
has cross-reference: MESH:D018245
has cross-reference: NCI:C3757
has cross-reference: SNOMEDCT_US_2020_03_01:75320001
has cross-reference: UMLS_CUI:C0206666
alternative_term: Placental site trophoblastic tumor
alternative_term: Placental site trophoblastic tumour
alternative_term: Placental-Site Gestational Trophoblastic neoplasm
alternative_term: placental site trophoblastic tumour
has_obo_namespace: disease_ontology
id: DOID:3596
in subset: NCIthesaurus

toxic encephalopathy
type: Class
subclass of: DOID 863
textual definition: A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems.
imported from: doid.owl
has cross-reference: MESH:D020258
has cross-reference: NCI:C27961
has cross-reference: SNOMEDCT_US_2020_03_01:19466003
has cross-reference: UMLS_CUI:C0235032
alternative_term: neurotoxicity
alternative_term: neurotoxicity syndrome
has_obo_namespace: disease_ontology
id: DOID:3602
in subset: NCIthesaurus

mucinous cystadenocarcinoma
type: Class
subclass of: cystadenocarcinoma
textual definition: A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells.
imported from: doid.owl
has cross-reference: MESH:D018282
has cross-reference: NCI:C3776
has cross-reference: SNOMEDCT_US_2020_03_01:79143006
has cross-reference: UMLS_CUI:C0206699
alternative_term: Pseudomucinous cystadenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:3603
in subset: NCIthesaurus

ovarian mucinous cystadenocarcinoma
type: Class
subclass of: ovarian cystadenocarcinoma
textual definition: An ovarian cystadenocarcinoma that is characterized by the presence of mucin.
imported from: doid.owl
has cross-reference: NCI:C4026
has cross-reference: SNOMEDCT_US_2020_03_01:254851009
has cross-reference: UMLS_CUI:C0279665
alternative_term: Ovarian mucinous cystadenocarcinoma
alternative_term: mucinous cystadenocarcinoma of ovary
has_obo_namespace: disease_ontology
id: DOID:3604
in subset: NCIthesaurus

ovarian cystadenocarcinoma
type: Class
subclass of: ovary adenocarcinoma
textual definition: An ovary adenocarcinoma that is characterized by the presence of cysts or cystic spaces.
imported from: doid.owl
has cross-reference: NCI:C5228
has cross-reference: SNOMEDCT_US_2020_03_01:314191009
has cross-reference: UMLS_CUI:C1096638
alternative_term: cystadenocarcinoma of ovary
alternative_term: cystadenocarcinoma of the Ovary
has_obo_namespace: disease_ontology
id: DOID:3605
in subset: NCIthesaurus

ovarian mucinous adenocarcinoma
type: Class
subclass of: mucinous adenocarcinoma
subclass of: ovary adenocarcinoma
textual definition: An ovary adenocarcinoma that is characterized by the presence of mucin.
imported from: doid.owl
has cross-reference: NCI:C5243
has cross-reference: UMLS_CUI:C1335167
alternative_term: mucinous carcinoma of Ovary
has_obo_namespace: disease_ontology
id: DOID:3606
in subset: NCIthesaurus

appendix adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: appendix carcinoma
textual definition: An appendix carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C7718
has cross-reference: SNOMEDCT_US_2020_03_01:413445002
has cross-reference: UMLS_CUI:C0238003
alternative_term: Appendiceal adenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:3608
in subset: NCIthesaurus

cervix endometriosis
type: Class
subclass of: cervix disease
textual definition: A cervix disease that is characterized by the growth endometrial tissue that is located on the cervix.
imported from: doid.owl
has cross-reference: NCI:C27623
has cross-reference: SNOMEDCT_US_2020_03_01:61640006
has cross-reference: UMLS_CUI:C0269107
alternative_term: Endometriosis of cervix
alternative_term: cervical Endometriosis
has_obo_namespace: disease_ontology
id: DOID:361
in subset: NCIthesaurus

retinitis
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: ICD10CM:H30.9
has cross-reference: MESH:D012173
has cross-reference: NCI:C115993
has cross-reference: SNOMEDCT_US_2020_03_01:35426003
has cross-reference: UMLS_CUI:C0035333
has_obo_namespace: disease_ontology
id: DOID:3612
in subset: NCIthesaurus

Canavan disease
type: Class
subclass of: autosomal recessive disease
subclass of: leukodystrophy
imported from: doid.owl
has cross-reference: GARD:5984
has cross-reference: MESH:D017825
has cross-reference: NCI:C84611
has cross-reference: OMIM:271900
has cross-reference: SNOMEDCT_US_2020_03_01:80544005
has cross-reference: UMLS_CUI:C0206307
alternative_term: CANAVAN-VAN BOGAERT-BERTRAND DISEASE
alternative_term: Spongy degeneration of central nervous system
has_obo_namespace: disease_ontology
id: DOID:3613
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Kallmann syndrome
type: Class
subclass of: hypogonadotropic hypogonadism
textual definition: A hypogonadotropic hypogonadism with a defective sense of smell (anosmia or hyposmia).
imported from: doid.owl
has cross-reference: GARD:10771
has cross-reference: ICD10CM:E23.0
has cross-reference: MESH:D017436
has cross-reference: NCI:C75479
has cross-reference: ORDO:478
has cross-reference: SNOMEDCT_US_2020_03_01:190559001
has cross-reference: UMLS_CUI:C0162809
alternative_term: Hypogonadism with anosmia
alternative_term: Kallman syndrome
alternative_term: Kallman's syndrome
alternative_term: familial hypogonadism with anosmia
has_obo_namespace: disease_ontology
id: DOID:3614
in subset: NCIthesaurus

angiolipoma
type: Class
subclass of: lipoma
textual definition: A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma.
imported from: doid.owl
has cross-reference: MESH:D018206
has cross-reference: NCI:C3733
has cross-reference: SNOMEDCT_US_2020_03_01:404057003
has cross-reference: UMLS_CUI:C0206632
has_obo_namespace: disease_ontology
id: DOID:3616
in subset: NCIthesaurus

central nervous system cancer
type: Class
subclass of: nervous system cancer
subclass of: central nervous system disease
textual definition: A nervous system cancer that is located_in the central nervous system.
imported from: doid.owl
has_alternative_id: DOID:0060093
has_alternative_id: DOID:1318
has cross-reference: EFO:0000326
has cross-reference: ICD10CM:C72.9
has cross-reference: MESH:D016543
has cross-reference: NCI:C4627
has cross-reference: NCI:C9293
has cross-reference: SNOMEDCT_US_2020_03_01:126951006
has cross-reference: SNOMEDCT_US_2020_03_01:93744007
has cross-reference: UMLS_CUI:C0085136
has cross-reference: UMLS_CUI:C0348374
alternative_term: CNS neoplasm
alternative_term: central nervous system tumor
alternative_term: central nervous system tumors
alternative_term: malignant neoplasm of central nervous system
alternative_term: malignant tumor of CNS
alternative_term: neoplasm of central nervous system
has_obo_namespace: disease_ontology
id: DOID:3620
in subset: NCIthesaurus

aortic aneurysm
type: Class
subclass of: aortic disease
textual definition: An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.
imported from: doid.owl
has_alternative_id: DOID:11138
has_alternative_id: DOID:7682
has_alternative_id: DOID:7692
has_alternative_id: DOID:7703
has cross-reference: ICD10CM:I71.1
has cross-reference: ICD10CM:I71.3
has cross-reference: ICD10CM:I71.5
has cross-reference: ICD10CM:I71.8
has cross-reference: ICD10CM:I71.9
has cross-reference: ICD9CM:441.1
has cross-reference: ICD9CM:441.3
has cross-reference: ICD9CM:441.5
has cross-reference: ICD9CM:441.6
has cross-reference: MESH:D001014
has cross-reference: MESH:D001019
has cross-reference: NCI:C26697
has cross-reference: NCI:C27046
has cross-reference: NCI:C27198
has cross-reference: NCI:C27299
has cross-reference: SNOMEDCT_US_2020_03_01:14336007
has cross-reference: SNOMEDCT_US_2020_03_01:155419006
has cross-reference: SNOMEDCT_US_2020_03_01:195265003
has cross-reference: SNOMEDCT_US_2020_03_01:34365005
has cross-reference: SNOMEDCT_US_2020_03_01:73067008
has cross-reference: UMLS_CUI:C0003486
has cross-reference: UMLS_CUI:C0265010
has cross-reference: UMLS_CUI:C0265012
has cross-reference: UMLS_CUI:C0741160
has cross-reference: UMLS_CUI:C1305122
alternative_term: ruptured aortic aneurysm
has_obo_namespace: disease_ontology
id: DOID:3627
in subset: NCIthesaurus

uterine cancer
type: Class
subclass of: female reproductive organ cancer
subclass of: uterine disease
textual definition: A female reproductive organ cancer that is located_in the uterus.
imported from: doid.owl
has_alternative_id: DOID:4363
has cross-reference: ICD10CM:C55
has cross-reference: ICD9CM:179
has cross-reference: MESH:D014594
has cross-reference: NCI:C3435
has cross-reference: NCI:C3552
has cross-reference: SNOMEDCT_US_2020_03_01:126908007
has cross-reference: SNOMEDCT_US_2020_03_01:371973000
has cross-reference: UMLS_CUI:C0042138
has cross-reference: UMLS_CUI:C0153567
alternative_term: CA - cancer of uterus
alternative_term: Tumour of uterus
alternative_term: malignant neoplasm of uterus
alternative_term: malignant uterine tumor
alternative_term: neoplasm of uterus
alternative_term: uterine tumor
alternative_term: uterus neoplasm
has_obo_namespace: disease_ontology
id: DOID:363
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

beta-mannosidosis
type: Class
subclass of: lysosomal storage disease
textual definition: A lysosomal storage disease that has_material_basis_in deficiency of the beta-A-manosidase enzyme resulting in the disruption of N-linked glycoprotein oligosaccharide catabolism.
imported from: doid.owl
has cross-reference: MESH:D044905
has cross-reference: NCI:C84596
has cross-reference: OMIM:248510
has cross-reference: SNOMEDCT_US_2020_03_01:238047006
has cross-reference: UMLS_CUI:C4048196
alternative_term: Beta-D-mannosidosis
alternative_term: beta-mannosidase deficiency
alternative_term: lysosomal beta-mannosidase deficiency
has_obo_namespace: disease_ontology
id: DOID:3633
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

congenital myasthenic syndrome
type: Class
subclass of: physical disorder
subclass of: neuromuscular junction disease
textual definition: A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic).
imported from: doid.owl
has cross-reference: GARD:11902
has cross-reference: MESH:D020294
has cross-reference: NCI:C84647
has cross-reference: OMIM:PS601462
has cross-reference: ORDO:590
has cross-reference: SNOMEDCT_US_2020_03_01:230672006
has cross-reference: UMLS_CUI:C0751882
has_obo_namespace: disease_ontology
id: DOID:3635
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

central nervous system teratoma
type: Class
subclass of: sarcoma
subclass of: central nervous system germ cell tumor
textual definition: A teratoma that is located_in the central nervous system.
imported from: doid.owl
has cross-reference: NCI:C5441
has cross-reference: UMLS_CUI:C1332895
alternative_term: CNS teratoma
has_obo_namespace: disease_ontology
id: DOID:3640
in subset: NCIthesaurus

empty sella syndrome
type: Class
subclass of: pituitary gland disease
imported from: doid.owl
has cross-reference: GARD:6331
has cross-reference: MESH:D004652
has cross-reference: NCI:C84686
has cross-reference: SNOMEDCT_US_2020_03_01:393569006
has cross-reference: UMLS_CUI:C0014008
alternative_term: Empty sella syndrome
has_obo_namespace: disease_ontology
id: DOID:3642
in subset: NCIthesaurus

necrosis of pituitary
type: Class
subclass of: pituitary gland disease
imported from: doid.owl
has cross-reference: NCI:C27066
has cross-reference: SNOMEDCT_US_2020_03_01:59572000
has cross-reference: UMLS_CUI:C0271558
alternative_term: Pituitary necrosis
has_obo_namespace: disease_ontology
id: DOID:3646
in subset: NCIthesaurus

pyruvate decarboxylase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
textual definition: A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex.
imported from: doid.owl
has cross-reference: GARD:4620
has cross-reference: GARD:7513
has cross-reference: ICD10CM:E74.4
has cross-reference: MESH:D015325
has cross-reference: NCI:C103968
has cross-reference: OMIM:245348
has cross-reference: OMIM:245349
has cross-reference: OMIM:312170
has cross-reference: OMIM:608782
has cross-reference: OMIM:614111
has cross-reference: ORDO:79243
has cross-reference: SNOMEDCT_US_2020_03_01:46683007
has cross-reference: UMLS_CUI:C0034345
alternative_term: deficiency of pyruvic dehydrogenase
alternative_term: pyruvate dehydrogenase complex deficiency disease
alternative_term: pyruvate dehydrogenase deficiency
has_obo_namespace: disease_ontology
id: DOID:3649
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

bladder disease
type: Class
subclass of: urinary system disease
textual definition: A urinary system disease that is located_in the bladder.
imported from: doid.owl
has cross-reference: ICD10CM:N32.9
has cross-reference: ICD9CM:596.9
has cross-reference: MESH:D001745
has cross-reference: NCI:C2900
has cross-reference: SNOMEDCT_US_2020_03_01:42643001
has cross-reference: UMLS_CUI:C0005686
alternative_term: Urinary Bladder Disease
has_obo_namespace: disease_ontology
id: DOID:365
in subset: NCIthesaurus

lactic acidosis
type: Class
subclass of: metabolic acidosis
textual definition: A metabolic acidosis characterized by buildup of lactate.
imported from: doid.owl
has cross-reference: ICD10CM:E87.2
has cross-reference: MESH:D000140
has cross-reference: NCI:C98969
has cross-reference: SNOMEDCT_US_2020_03_01:91273001
has cross-reference: UMLS_CUI:C0001125
has_obo_namespace: disease_ontology
id: DOID:3650
in subset: NCIthesaurus

Leigh disease
type: Class
subclass of: mitochondrial metabolism disease
textual definition: A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.
imported from: doid.owl
has cross-reference: GARD:6877
has cross-reference: ICD10CM:G31.82
has cross-reference: MESH:D007888
has cross-reference: NCI:C84814
has cross-reference: OMIM:256000
has cross-reference: ORDO:506
has cross-reference: SNOMEDCT_US_2020_03_01:29570005
has cross-reference: UMLS_CUI:C0023264
alternative_term: Infantile necrotizing encephalomyelopathy
alternative_term: Leigh syndrome
alternative_term: juvenile subacute necrotizing encephalomyelopathy
has_obo_namespace: disease_ontology
has_related_synonym: subacute necrotizing encephalomyelopathy
id: DOID:3652
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

sialuria
type: Class
subclass of: lysosomal storage disease
textual definition: A lysosomal storage disease characterized by increased sialic acid in the urine.
imported from: doid.owl
has cross-reference: MESH:D029461
has cross-reference: NCI:C85067
has cross-reference: OMIM:269921
has cross-reference: OMIM:604369
has cross-reference: SNOMEDCT_US_2020_03_01:238051008
has cross-reference: UMLS_CUI:C0342853
has_obo_namespace: disease_ontology
id: DOID:3659
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS]. OMIM mapping submitted by NeuroDevNet. [LS].

olfactory nerve neoplasm
type: Class
subclass of: cranial nerve malignant neoplasm
imported from: doid.owl
has cross-reference: NCI:C5121
has cross-reference: SNOMEDCT_US_2020_03_01:126967000
has cross-reference: UMLS_CUI:C0346319
alternative_term: neoplasm of olfactory nerve
alternative_term: tumor of Olfactory nerve
has_obo_namespace: disease_ontology
id: DOID:366
in subset: NCIthesaurus

mast cell neoplasm
type: Class
subclass of: cell type cancer
subclass of: hematologic cancer
textual definition: A hematologic cancer that has_material_basis_in mast cells.
imported from: doid.owl
has cross-reference: ICD10CM:D47.09
has cross-reference: NCI:C9295
has cross-reference: SNOMEDCT_US_2020_03_01:127581004
has cross-reference: UMLS_CUI:C0334664
alternative_term: Mast cell Proliferative disease
alternative_term: mast cell tumor
alternative_term: mastocytoma
has_obo_namespace: disease_ontology
id: DOID:3664
in subset: DO cancer slim
in subset: NCIthesaurus

intermittent claudication
type: Class
subclass of: arteriosclerosis
imported from: doid.owl
has cross-reference: ICD10CM:I73.9
has cross-reference: MESH:D007383
has cross-reference: SNOMEDCT_US_2020_03_01:195312007
has cross-reference: UMLS_CUI:C0021775
alternative_term: Charcot's syndrome
alternative_term: Intermittent claudication
has_obo_namespace: disease_ontology
id: DOID:3669

rhabdoid cancer
type: Class
subclass of: childhood kidney cancer
textual definition: A childhood kidney neoplasm that is located_in the kidney, liver, muscle, heart, lung, soft tissues, skin and central nervous system.
imported from: doid.owl
has cross-reference: GARD:7572
has cross-reference: MESH:D018335
has cross-reference: NCI:C3808
has cross-reference: SNOMEDCT_US_2020_03_01:83118000
has cross-reference: UMLS_CUI:C0206743
alternative_term: Rhabdoid sarcoma
alternative_term: malignant rhabdoid tumour
has_obo_namespace: disease_ontology
has_related_synonym: rhabdoid tumor
id: DOID:3672
in subset: NCIthesaurus

childhood kidney cancer
type: Class
subclass of: kidney cancer
imported from: doid.owl
has cross-reference: NCI:C6563
has cross-reference: UMLS_CUI:C1333003
alternative_term: pediatric renal tumor
has_obo_namespace: disease_ontology
id: DOID:3675
in subset: DO cancer slim
in subset: NCIthesaurus

cerebrum cancer
type: Class
subclass of: supratentorial cancer
textual definition: A supratentorial cancer that is located_in the cerebrum.
imported from: doid.owl
has_alternative_id: DOID:912
has cross-reference: ICD9CM:191.8
has cross-reference: NCI:C4874
has cross-reference: SNOMEDCT_US_2020_03_01:126953009
has cross-reference: SNOMEDCT_US_2020_03_01:188300006
has cross-reference: UMLS_CUI:C0153642
has cross-reference: UMLS_CUI:C1263885
alternative_term: cerebral cancer
alternative_term: neoplasm of cerebrum
alternative_term: tumor of Cerebrum
has_obo_namespace: disease_ontology
id: DOID:368
in subset: NCIthesaurus

lung benign neoplasm
type: Class
subclass of: respiratory system benign neoplasm
subclass of: lung disease
imported from: doid.owl
has cross-reference: MESH:D008175
has cross-reference: NCI:C3200
has cross-reference: SNOMEDCT_US_2020_03_01:126713003
has cross-reference: UMLS_CUI:C0024121
alternative_term: tumor of the lung
has_obo_namespace: disease_ontology
id: DOID:3683
in subset: NCIthesaurus

MELAS syndrome
type: Class
subclass of: DOID 890
textual definition: A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, has_symptom myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and severe headaches, and develops_from mutation in mitochondrial genes including MT-TL1, which encodes tRNA proteins.
imported from: doid.owl
has cross-reference: ICD10CM:E88.41
has cross-reference: MESH:D017241
has cross-reference: NCI:C84885
has cross-reference: OMIM:540000
has cross-reference: SNOMEDCT_US_2020_03_01:39925003
has cross-reference: UMLS_CUI:C0162671
alternative_term: MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES
has_obo_namespace: disease_ontology
id: DOID:3687
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

brachial plexus neuritis
type: Class
subclass of: neuritis
subclass of: brachial plexus neuropathy
imported from: doid.owl
has cross-reference: ICD10CM:G54.5
has cross-reference: MESH:D020968
has cross-reference: NCI:C84600
has cross-reference: SNOMEDCT_US_2020_03_01:26609002
has cross-reference: UMLS_CUI:C0221759
alternative_term: Brachial neuritis
alternative_term: Parsonage-Aldren-Turner syndrome
has_obo_namespace: disease_ontology
id: DOID:3689
in subset: NCIthesaurus

olfactory neuroblastoma
type: Class
subclass of: olfactory nerve neoplasm
imported from: doid.owl
has cross-reference: GARD:2197
has cross-reference: MESH:D018304
has cross-reference: NCI:C3789
has cross-reference: SNOMEDCT_US_2020_03_01:76060004
has cross-reference: UMLS_CUI:C0206717
alternative_term: Asthesioneuroblastoma
alternative_term: Esthesioneuroblastoma
alternative_term: Esthesioneuroepithelioma
alternative_term: Olfactory Esthesioneuroblastoma
alternative_term: paranasal sinus Olfactory neuroblastoma
has_obo_namespace: disease_ontology
id: DOID:369
in subset: NCIthesaurus

brachial plexus neuropathy
type: Class
subclass of: DOID 870
imported from: doid.owl
has cross-reference: ICD10CM:G54.0
has cross-reference: MESH:D020516
has cross-reference: NCI:C27194
has cross-reference: SNOMEDCT_US_2020_03_01:3548001
has cross-reference: UMLS_CUI:C0700251
alternative_term: Brachial plexus disorder
alternative_term: brachial plexopathy
has_obo_namespace: disease_ontology
id: DOID:3690
in subset: NCIthesaurus

skin disease
type: Class
subclass of: integumentary system disease
textual definition: An integumentary system disease that is located_in skin.
imported from: doid.owl
has_alternative_id: DOID:1576
has_alternative_id: DOID:1698
has_alternative_id: DOID:187
has_alternative_id: DOID:6486
has_alternative_id: DOID:8948
has cross-reference: ICD9CM:702
has cross-reference: MESH:D012871
has cross-reference: MESH:D012873
has cross-reference: NCI:C156032
has cross-reference: NCI:C3371
has cross-reference: SNOMEDCT_US_2020_03_01:201095006
has cross-reference: SNOMEDCT_US_2020_03_01:5613003
has cross-reference: SNOMEDCT_US_2020_03_01:95320005
has cross-reference: UMLS_CUI:C0029574
has cross-reference: UMLS_CUI:C0037274
has cross-reference: UMLS_CUI:C0037277
alternative_term: Genodermatosis
alternative_term: skin and subcutaneous tissue disease
has_obo_namespace: disease_ontology
id: DOID:37
in subset: NCIthesaurus

fallopian tube adenocarcinoma
type: Class
subclass of: fallopian tube carcinoma
subclass of: adenocarcinoma
textual definition: A fallopian tube carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C6265
has cross-reference: UMLS_CUI:C1333590
alternative_term: adenocarcinoma of the fallopian tube
has_obo_namespace: disease_ontology
id: DOID:3706
in subset: NCIthesaurus

bladder adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: bladder carcinoma
textual definition: A bladder carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C4032
has cross-reference: SNOMEDCT_US_2020_03_01:255110003
has cross-reference: UMLS_CUI:C0279682
alternative_term: adenocarcinoma of bladder
alternative_term: adenocarcinoma of the urinary bladder
alternative_term: bladder adenocarcinoma, Not Otherwise Specified
has_obo_namespace: disease_ontology
id: DOID:3711
in subset: NCIthesaurus

ovary adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: ovarian carcinoma
textual definition: An ovarian carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has_alternative_id: DOID:7816
has cross-reference: NCI:C7700
has cross-reference: UMLS_CUI:C0948216
alternative_term: Ovarian adenocarcinoma
alternative_term: ovarian adenoacanthoma
has_obo_namespace: disease_ontology
has_related_synonym: adenocarcinoma of the ovary
id: DOID:3713
in subset: NCIthesaurus

gastric adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: stomach carcinoma
textual definition: A stomach carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C4004
has cross-reference: SNOMEDCT_US_2020_03_01:408647009
has cross-reference: UMLS_CUI:C0278701
alternative_term: adenocarcinoma of stomach
alternative_term: stomach adenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:3717
in subset: DO cancer slim
in subset: NCIthesaurus

plasmacytoma
type: Class
subclass of: plasma cell neoplasm
imported from: doid.owl
has cross-reference: ICD10CM:C90.3
has cross-reference: MESH:D010954
has cross-reference: NCI:C9349
has cross-reference: SNOMEDCT_US_2020_03_01:302852008
has cross-reference: UMLS_CUI:C0032131
alternative_term: Myeloma - solitary
alternative_term: Myeloma, solitary
alternative_term: Solitary myeloma
alternative_term: Solitary plasmacytoma
has_obo_namespace: disease_ontology
id: DOID:3721
in subset: NCIthesaurus

theileriasis
type: Class
subclass of: parasitic protozoa infectious disease
textual definition: A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks.
imported from: doid.owl
has cross-reference: MESH:D013801
has cross-reference: SNOMEDCT_US_2020_03_01:68771000
has cross-reference: UMLS_CUI:C0039753
alternative_term: Infection by Theileria
alternative_term: theileriosis
has_obo_namespace: disease_ontology
id: DOID:3733
in subset: tick-borne infectious disease

verrucous carcinoma
type: Class
subclass of: squamous cell carcinoma
textual definition: A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.
imported from: doid.owl
has cross-reference: MESH:D018289
has cross-reference: NCI:C3781
has cross-reference: SNOMEDCT_US_2020_03_01:89906000
has cross-reference: UMLS_CUI:C0206706
alternative_term: Warty carcinoma
alternative_term: verrucous squamous carcinoma
alternative_term: verrucous squamous cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:3737
in subset: NCIthesaurus

nutrition disease
type: Class
subclass of: acquired metabolic disease
textual definition: An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods.
imported from: doid.owl
has cross-reference: MESH:D009748
has cross-reference: NCI:C26836
has cross-reference: SNOMEDCT_US_2020_03_01:191077005
has cross-reference: UMLS_CUI:C3714509
alternative_term: Nutritional disorder
has_obo_namespace: disease_ontology
id: DOID:374
in subset: NCIthesaurus

cervical squamous cell carcinoma
type: Class
subclass of: squamous cell carcinoma
subclass of: cervix carcinoma
textual definition: A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
imported from: doid.owl
has cross-reference: NCI:C4028
has cross-reference: SNOMEDCT_US_2020_03_01:254886006
has cross-reference: UMLS_CUI:C0279671
alternative_term: squamous cell carcinoma of cervix
alternative_term: squamous cell carcinoma of the Cervix Uteri
has_obo_namespace: disease_ontology
id: DOID:3744
in subset: DO cancer slim
in subset: NCIthesaurus

esophagus squamous cell carcinoma
type: Class
subclass of: esophageal carcinoma
subclass of: squamous cell carcinoma
textual definition: An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.
imported from: doid.owl
has cross-reference: MESH:D000077277
has cross-reference: NCI:C4024
has cross-reference: SNOMEDCT_US_2020_03_01:276804009
has cross-reference: UMLS_CUI:C0279626
alternative_term: SCC of esophagus
alternative_term: SCC of oesophagus
alternative_term: oesophagus squamous cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:3748
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

larynx verrucous carcinoma
type: Class
subclass of: laryngeal squamous cell carcinoma
imported from: doid.owl
has cross-reference: NCI:C8188
has cross-reference: UMLS_CUI:C0280328
alternative_term: verrucous carcinoma of the Larynx
has_obo_namespace: disease_ontology
id: DOID:3752
in subset: NCIthesaurus

Hermansky-Pudlak syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by oculocutaneous albinism, bleeding problems due to platelet storage pool defect, visual impairment and lysosomal accumulation of ceroid lipofuscin.
imported from: doid.owl
has cross-reference: GARD:6643
has cross-reference: ICD10CM:E70.331
has cross-reference: MESH:D022861
has cross-reference: NCI:C37261
has cross-reference: OMIM:PS203300
has cross-reference: ORDO:231531
has cross-reference: ORDO:231537
has cross-reference: ORDO:280663
has cross-reference: ORDO:79430
has cross-reference: SNOMEDCT_US_2020_03_01:60255003
has cross-reference: UMLS_CUI:C0079504
has_obo_namespace: disease_ontology
id: DOID:3753
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

antithrombin III deficiency
type: Class
subclass of: autosomal dominant disease
subclass of: autosomal recessive disease
subclass of: thrombophilia
textual definition: A thrombophilia that is characterized by the tendency to form clots in the veins.
imported from: doid.owl
has cross-reference: ICD10CM:D68.59
has cross-reference: MESH:D020152
has cross-reference: NCI:C98815
has cross-reference: OMIM:613118
has cross-reference: SNOMEDCT_US_2020_03_01:36351005
has cross-reference: UMLS_CUI:C0272375
alternative_term: AT III deficiency
alternative_term: hereditary thrombophilia due to congenital antithrombin deficiency
has_obo_namespace: disease_ontology
id: DOID:3755
in subset: NCIthesaurus
comment: Xref MGI.

protein C deficiency
type: Class
subclass of: autosomal dominant disease
subclass of: thrombophilia
textual definition: A thrombophilia that is characterized by recurrent venous thrombosis and that has_material_basis_in heterozygous mutation in the PROC gene on chromosome 2q14.
imported from: doid.owl
has cross-reference: GARD:4521
has cross-reference: ICD10CM:D68.59
has cross-reference: MESH:D020151
has cross-reference: NCI:C99025
has cross-reference: ORDO:745
has cross-reference: SNOMEDCT_US_2020_03_01:76407009
has cross-reference: UMLS_CUI:C0398625
has_obo_namespace: disease_ontology
id: DOID:3756
in subset: NCIthesaurus

hermaphroditism
type: Class
subclass of: disorder of sexual development
imported from: doid.owl
has cross-reference: MESH:D012734
has cross-reference: NCI:C45909
has cross-reference: SNOMEDCT_US_2020_03_01:52572004
has cross-reference: UMLS_CUI:C0019269
has_obo_namespace: disease_ontology
id: DOID:3763
in subset: NCIthesaurus

Denys-Drash syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene).
imported from: doid.owl
has cross-reference: GARD:5576
has cross-reference: MESH:D030321
has cross-reference: NCI:C84668
has cross-reference: OMIM:194080
has cross-reference: SNOMEDCT_US_2020_03_01:236385009
has cross-reference: UMLS_CUI:C0950121
has_obo_namespace: disease_ontology
id: DOID:3764
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pseudohermaphroditism
type: Class
subclass of: disorder of sexual development
imported from: doid.owl
has_alternative_id: DOID:11226
has cross-reference: ICD10CM:Q56
has cross-reference: ICD10CM:Q56.3
has cross-reference: ICD9CM:752.7
has cross-reference: MESH:D012734
has cross-reference: NCI:C124575
has cross-reference: SNOMEDCT_US_2020_03_01:204895009
has cross-reference: SNOMEDCT_US_2020_03_01:268328009
has cross-reference: UMLS_CUI:C0021193
has cross-reference: UMLS_CUI:C0033804
alternative_term: Indeterminate sex and pseudohermaphroditism
has_obo_namespace: disease_ontology
id: DOID:3765
in subset: NCIthesaurus

leukorrhea
type: Class
subclass of: vaginal discharge
textual definition: A vaginal discharge that is characterized by a whitish or yellow color.
imported from: doid.owl
has cross-reference: ICD10CM:N89.8
has cross-reference: MESH:D007973
has cross-reference: NCI:C34775
has cross-reference: SNOMEDCT_US_2020_03_01:156017008
has cross-reference: UMLS_CUI:C0023533
alternative_term: Leukorrhea of vagina
alternative_term: discharge - leukorrhea
has_obo_namespace: disease_ontology
id: DOID:3766
in subset: NCIthesaurus

vaginal discharge
type: Class
subclass of: vaginal disease
textual definition: A vaginal disease that is characterized by the presence of discharge.
imported from: doid.owl
has cross-reference: MESH:D019522
has cross-reference: NCI:C50795
has cross-reference: SNOMEDCT_US_2020_03_01:70856007
has cross-reference: UMLS_CUI:C0227791
has_obo_namespace: disease_ontology
id: DOID:3767
in subset: NCIthesaurus

pulmonary fibrosis
type: Class
subclass of: interstitial lung disease
textual definition: An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation.
imported from: doid.owl
has cross-reference: MESH:D011658
has cross-reference: NCI:C26869
has cross-reference: SNOMEDCT_US_2020_03_01:155613001
has cross-reference: UMLS_CUI:C0034069
alternative_term: Fibrosis of lung
has_obo_namespace: disease_ontology
id: DOID:3770
in subset: NCIthesaurus

chordoid glioma
type: Class
subclass of: malignant glioma
imported from: doid.owl
has cross-reference: NCI:C5592
has cross-reference: SNOMEDCT_US_2020_03_01:128789002
has cross-reference: UMLS_CUI:C1322252
alternative_term: Chordoid glioma
has_obo_namespace: disease_ontology
id: DOID:3774
in subset: DO rare slim
in subset: NCIthesaurus

anovulation
type: Class
subclass of: ovarian disease
textual definition: An ovarian disease that is characterized by the absence of ovulation.
imported from: doid.owl
has cross-reference: MESH:D000858
has cross-reference: NCI:C34388
has cross-reference: SNOMEDCT_US_2020_03_01:34571000
has cross-reference: UMLS_CUI:C0003128
has_obo_namespace: disease_ontology
id: DOID:3781
in subset: NCIthesaurus

Coffin-Lowry syndrome
type: Class
subclass of: X-linked dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by skeletal malformations, growth retardation, hearing deficit, paroxysmal movement disorders, and cognitive impairment in affected males and some carrier females, and has_material_basis_in mutation in the RSK2 gene on chromosome Xp22.
imported from: doid.owl
has cross-reference: GARD:6123
has cross-reference: MESH:D038921
has cross-reference: NCI:C84643
has cross-reference: OMIM:303600
has cross-reference: SNOMEDCT_US_2020_03_01:15182000
has cross-reference: UMLS_CUI:C0265252
has_obo_namespace: disease_ontology
id: DOID:3783
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

external ear disease
type: Class
subclass of: auditory system disease
imported from: doid.owl
has_alternative_id: DOID:13122
has_alternative_id: DOID:835
has cross-reference: ICD10CM:H61.9
has cross-reference: ICD9CM:380
has cross-reference: NCI:C26972
has cross-reference: SNOMEDCT_US_2020_03_01:49130001
has cross-reference: UMLS_CUI:C0155388
alternative_term: Preauricular cyst
alternative_term: Preauricular sinus and fistula
alternative_term: Preauricular sinus or fistula
has_obo_namespace: disease_ontology
id: DOID:379
in subset: NCIthesaurus

pleural empyema
type: Class
subclass of: pleural disease
textual definition: A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath.
imported from: doid.owl
has_alternative_id: DOID:11023
has_alternative_id: DOID:13630
has_alternative_id: DOID:14304
has cross-reference: ICD10CM:J86
has cross-reference: MESH:D016724
has cross-reference: NCI:C45692
has cross-reference: SNOMEDCT_US_2020_03_01:196069007
has cross-reference: UMLS_CUI:C0014013
alternative_term: Empyema
alternative_term: Empyema of pleura
alternative_term: Empyema of pleura without fistula
alternative_term: Empyema with fistula
alternative_term: Empyema with no fistula
alternative_term: Empyema with pleural fistula
alternative_term: Empyema without mention of fistula
alternative_term: Empyema, chest
alternative_term: Pleural empyema with fistula
alternative_term: Purulent pleurisy
alternative_term: Thorax abscess
alternative_term: abscess of pleural cavity
alternative_term: abscess of thorax
alternative_term: empyema
alternative_term: empyema with fistula
alternative_term: lung empyema
alternative_term: pleural empyema with no fistula
alternative_term: purulent pleuritis
alternative_term: pyothorax
has_obo_namespace: disease_ontology
id: DOID:3798
in subset: NCIthesaurus
comment: Updating outdated UMLS CUI.

arthropathy
type: Class
subclass of: bone disease
textual definition: A bone disease that is located_in the joint.
imported from: doid.owl
has_alternative_id: DOID:13871
has_alternative_id: DOID:13960
has_alternative_id: DOID:1843
has_alternative_id: DOID:1903
has_alternative_id: DOID:226
has_alternative_id: DOID:2317
has_alternative_id: DOID:2318
has_alternative_id: DOID:546
has_alternative_id: DOID:9489
has cross-reference: ICD10CM:M00-M02
has cross-reference: ICD10CM:M12.9
has cross-reference: ICD9CM:711
has cross-reference: ICD9CM:719.90
has cross-reference: MESH:D007592
has cross-reference: NCI:C35760
has cross-reference: NCI:C78402
has cross-reference: SNOMEDCT_US_2020_03_01:48548006
has cross-reference: SNOMEDCT_US_2020_03_01:8316001
has cross-reference: UMLS_CUI:C0022408
has cross-reference: UMLS_CUI:C0157749
alternative_term: Ankylosis of joint of ankle and/or foot
alternative_term: Ankylosis of joint of forearm
alternative_term: Ankylosis of joint of hand
alternative_term: Ankylosis of joint of lower leg
alternative_term: Ankylosis of joint of multiple sites
alternative_term: Ankylosis of joint of shoulder region
alternative_term: Ankylosis of joint of upper arm
alternative_term: Ankylosis of multiple joints
alternative_term: Infectious arthropathy
alternative_term: Joint ankylosis of the ankle and foot
alternative_term: Joint ankylosis of the ankle and/or foot
alternative_term: Joint ankylosis of the forearm
alternative_term: Joint ankylosis of the hand
alternative_term: Joint ankylosis of the lower leg
alternative_term: Joint ankylosis of the pelvic region and thigh
alternative_term: Joint ankylosis of the shoulder region
alternative_term: Joint ankylosis of the upper arm
alternative_term: ankylosis of ankle and foot joint
alternative_term: ankylosis of forearm joint
alternative_term: ankylosis of hand joint
alternative_term: ankylosis of joint of multiple sites
alternative_term: ankylosis of joint of pelvic region and thigh
alternative_term: ankylosis of joint of shoulder region
alternative_term: ankylosis of lower leg joint
alternative_term: ankylosis of upper arm joint
has_obo_namespace: disease_ontology
id: DOID:381
in subset: NCIthesaurus

photoallergic dermatitis
type: Class
subclass of: allergic contact dermatitis
textual definition: An allergic contact dermatitis that is characterized by a delayed-type hypersensitivity cutaneous reaction in response to a photoantigen applied to the skin in individuals previously sensitized to the same substance, and has_symptom erythematous papules, vesicles, or eczema.
imported from: doid.owl
has cross-reference: MESH:D017454
has cross-reference: SNOMEDCT_US_2020_03_01:111209006
has cross-reference: UMLS_CUI:C0162824
alternative_term: Photoallergic contact dermatitis
alternative_term: Photoallergic dermatitis
alternative_term: Photoallergic eczema
has_obo_namespace: disease_ontology
id: DOID:3818

congenital diaphragmatic hernia
type: Class
subclass of: physical disorder
subclass of: diaphragm disease
textual definition: A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs.
imported from: doid.owl
has cross-reference: GARD:1481
has cross-reference: ICD10CM:K44
has cross-reference: MESH:D006548
has cross-reference: NCI:C34687
has cross-reference: OMIM:142340
has cross-reference: OMIM:222400
has cross-reference: OMIM:610187
has cross-reference: ORDO:2140
has cross-reference: SNOMEDCT_US_2020_03_01:155748004
has cross-reference: UMLS_CUI:C0019284
alternative_term: Diaphragmatic Hernia
has_obo_namespace: disease_ontology
id: DOID:3827
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

pituitary adenoma
type: Class
subclass of: pituitary gland benign neoplasm
subclass of: adenoma
textual definition: A pituitary gland benign neoplasm that derives_from glandular epithelial cells.
imported from: doid.owl
has cross-reference: MESH:D010911
has cross-reference: NCI:C3329
has cross-reference: OMIM:PS102200
has cross-reference: SNOMEDCT_US_2020_03_01:154621002
has cross-reference: UMLS_CUI:C0032000
alternative_term: adenoma of the Pituitary gland
has_obo_namespace: disease_ontology
id: DOID:3829
in subset: NCIthesaurus

Wolff-Parkinson-White syndrome
type: Class
subclass of: heart conduction disease
imported from: doid.owl
has_alternative_id: DOID:10392
has cross-reference: GARD:7897
has cross-reference: ICD10CM:I45.6
has cross-reference: ICD9CM:426.7
has cross-reference: MESH:D014927
has cross-reference: NCI:C35132
has cross-reference: OMIM:194200
has cross-reference: SNOMEDCT_US_2020_03_01:195057009
has cross-reference: SNOMEDCT_US_2020_03_01:74390002
has cross-reference: UMLS_CUI:C0043202
has cross-reference: UMLS_CUI:C0392470
alternative_term: Anomalous A-V excitation
alternative_term: Wolff-Parkinson-White pattern
alternative_term: anomalous atrioventricular excitation
has_obo_namespace: disease_ontology
id: DOID:384
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS]. OMIM mapping confirmed by DO. [SN].

craniopharyngioma
type: Class
subclass of: central nervous system benign neoplasm
imported from: doid.owl
has cross-reference: GARD:10486
has cross-reference: MESH:D003397
has cross-reference: NCI:C2964
has cross-reference: SNOMEDCT_US_2020_03_01:189179009
has cross-reference: UMLS_CUI:C0010276
alternative_term: neoplasm of Rathke's Pouch
has_obo_namespace: disease_ontology
id: DOID:3840
in subset: NCIthesaurus

skull base cancer
type: Class
subclass of: skull cancer
imported from: doid.owl
has cross-reference: MESH:D019292
has cross-reference: NCI:C4676
has cross-reference: UMLS_CUI:C0376527
alternative_term: tumors of Skull Base
has_obo_namespace: disease_ontology
id: DOID:3842
in subset: NCIthesaurus

diencephalic neoplasm
type: Class
subclass of: supratentorial cancer
imported from: doid.owl
has_alternative_id: DOID:6097
has cross-reference: NCI:C5125
has cross-reference: NCI:C5126
has cross-reference: UMLS_CUI:C1333286
has cross-reference: UMLS_CUI:C1334576
alternative_term: malignant Diencephalic tumor
alternative_term: malignant diencephalic neoplasm
alternative_term: tumor of Diencephalon
has_obo_namespace: disease_ontology
id: DOID:3843
in subset: NCIthesaurus

Peutz-Jeghers syndrome
type: Class
subclass of: intestinal disease
imported from: doid.owl
has_alternative_id: DOID:4133
has_alternative_id: DOID:4134
has_alternative_id: DOID:6252
has_alternative_id: DOID:6253
has cross-reference: GARD:7378
has cross-reference: ICD10CM:Q85.8
has cross-reference: MESH:D010580
has cross-reference: NCI:C3324
has cross-reference: NCI:C4733
has cross-reference: NCI:C7755
has cross-reference: OMIM:175200
has cross-reference: ORDO:2869
has cross-reference: SNOMEDCT_US_2020_03_01:157029009
has cross-reference: SNOMEDCT_US_2020_03_01:277161008
has cross-reference: SNOMEDCT_US_2020_03_01:53633000
has cross-reference: UMLS_CUI:C0031269
has cross-reference: UMLS_CUI:C0265323
has cross-reference: UMLS_CUI:C0456487
alternative_term: Colonic hamartomatous polyp
alternative_term: Peutz Jeghers colon polyp
alternative_term: Peutz Jeghers polyp
alternative_term: Peutz-Jeghers polyp of small Intestine
alternative_term: gastric Peutz-Jeghers polyp
alternative_term: peutz-jeghers small bowel hamartoma
has_obo_namespace: disease_ontology
id: DOID:3852
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

seminal vesicle tumor
type: Class
subclass of: male reproductive organ benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C39908
has cross-reference: SNOMEDCT_US_2020_03_01:236740006
has cross-reference: UMLS_CUI:C0341767
alternative_term: Seminal Vesicle neoplasm
alternative_term: seminal vesicle tumour
alternative_term: tumor of seminal vesicle
alternative_term: tumour of seminal vesicle
has_obo_namespace: disease_ontology
id: DOID:3855
in subset: NCIthesaurus

male reproductive organ cancer
type: Class
subclass of: reproductive organ cancer
subclass of: male reproductive system disease
textual definition: A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.
imported from: doid.owl
has_alternative_id: DOID:10284
has cross-reference: ICD10CM:C63.9
has cross-reference: ICD9CM:187.9
has cross-reference: MESH:D005834
has cross-reference: NCI:C3054
has cross-reference: NCI:C8561
has cross-reference: SNOMEDCT_US_2020_03_01:126895004
has cross-reference: SNOMEDCT_US_2020_03_01:363515000
has cross-reference: UMLS_CUI:C0017417
has cross-reference: UMLS_CUI:C0153606
alternative_term: male genital cancer
alternative_term: male reproductive system neoplasm
alternative_term: malignant neoplasm of male genital organ
alternative_term: malignant neoplasm of male genital organ or tract
alternative_term: malignant neoplasm of male genital organs
alternative_term: malignant tumor of male Reproductive system
alternative_term: malignant tumor of male genital organ
alternative_term: neoplasm of male genital organ
alternative_term: tumor of male Reproductive system
has_obo_namespace: disease_ontology
has_related_synonym: male genital neoplasm
id: DOID:3856
in subset: NCIthesaurus

large cell medulloblastoma
type: Class
subclass of: medulloblastoma
textual definition: A medulloblastoma that is characterized by cells that are larger than would be normally expected.
imported from: doid.owl
has cross-reference: NCI:C6904
has cross-reference: SNOMEDCT_US_2020_03_01:128790006
has cross-reference: UMLS_CUI:C1266180
alternative_term: large cell Medulloblastoma
has_obo_namespace: disease_ontology
id: DOID:3857
in subset: DO cancer slim
in subset: NCIthesaurus

medullomyoblastoma
type: Class
subclass of: medulloblastoma
imported from: doid.owl
has cross-reference: MESH:D008527
has cross-reference: NCI:C3706
has cross-reference: SNOMEDCT_US_2020_03_01:24604009
has cross-reference: UMLS_CUI:C0205833
alternative_term: Medullomyoblastoma
has_obo_namespace: disease_ontology
id: DOID:3861
in subset: NCIthesaurus

adult medulloblastoma
type: Class
subclass of: medulloblastoma
imported from: doid.owl
has_alternative_id: DOID:6380
has cross-reference: MESH:D008527
has cross-reference: NCI:C4011
has cross-reference: NCI:C9373
has cross-reference: UMLS_CUI:C0278876
has cross-reference: UMLS_CUI:C1332188
alternative_term: adult brain medulloblastoma
has_obo_namespace: disease_ontology
id: DOID:3864
in subset: NCIthesaurus

childhood medulloblastoma
type: Class
subclass of: medulloblastoma
imported from: doid.owl
has cross-reference: MESH:D008527
has cross-reference: NCI:C3997
has cross-reference: UMLS_CUI:C0278510
alternative_term: pediatric Medulloblastoma
has_obo_namespace: disease_ontology
id: DOID:3869
in subset: DO cancer slim
in subset: NCIthesaurus

functional colonic disease
type: Class
subclass of: colonic disease
imported from: doid.owl
has cross-reference: MESH:D003109
has cross-reference: UMLS_CUI:C0009374
has_obo_namespace: disease_ontology
id: DOID:3877

Lynch syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers.
imported from: doid.owl
has_alternative_id: DOID:0050586
has_alternative_id: DOID:3040
has cross-reference: GARD:9905
has cross-reference: MESH:D003123
has cross-reference: NCI:C120083
has cross-reference: OMIM:PS120435
has cross-reference: ORDO:144
has cross-reference: SNOMEDCT_US_2020_03_01:315058005
has cross-reference: UMLS_CUI:C0009405
has cross-reference: UMLS_CUI:C1333990
alternative_term: COCA 1
alternative_term: HNPCC - hereditary nonpolyposis colon cancer
alternative_term: Hereditary Defective Mismatch Repair syndrome
alternative_term: hereditary nonpolyposis colorectal cancer
alternative_term: hereditary nonpolyposis colorectal neoplasm
has_obo_namespace: disease_ontology
id: DOID:3883
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

acute intermittent porphyria
type: Class
subclass of: acute porphyria
imported from: doid.owl
has cross-reference: GARD:5732
has cross-reference: MESH:D017118
has cross-reference: NCI:C84536
has cross-reference: OMIM:176000
has cross-reference: SNOMEDCT_US_2020_03_01:190914003
has cross-reference: UMLS_CUI:C0162565
alternative_term: AIP - acute intermittent porphyria
alternative_term: Pyrroloporphyria
alternative_term: porphyria intermittent acute
has_obo_namespace: disease_ontology
id: DOID:3890
in subset: NCIthesaurus

placental insufficiency
type: Class
subclass of: placenta disease
textual definition: A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.
imported from: doid.owl
has cross-reference: MESH:D010927
has cross-reference: SNOMEDCT_US_2020_03_01:156185006
has cross-reference: UMLS_CUI:C0032051
has_obo_namespace: disease_ontology
id: DOID:3891

insulinoma
type: Class
subclass of: cell type benign neoplasm
subclass of: pancreatic cystadenoma
textual definition: A pancreatic cystadenoma that is characterized by the overproduction of insulin.
imported from: doid.owl
has_alternative_id: DOID:3903
has cross-reference: GARD:3010
has cross-reference: MESH:D007340
has cross-reference: MESH:D007516
has cross-reference: NCI:C65184
has cross-reference: NCI:C95598
has cross-reference: SNOMEDCT_US_2020_03_01:189586007
has cross-reference: SNOMEDCT_US_2020_03_01:25324008
has cross-reference: UMLS_CUI:C0021670
has cross-reference: UMLS_CUI:C0022134
alternative_term: Insulin-Producing tumor of Islet cells
alternative_term: Islet cell adenoma
has_obo_namespace: disease_ontology
id: DOID:3892
in subset: NCIthesaurus

hidrocystoma
type: Class
subclass of: apocrine sweat gland neoplasm
imported from: doid.owl
has cross-reference: MESH:D018251
has cross-reference: NCI:C3760
has cross-reference: SNOMEDCT_US_2020_03_01:80549000
has cross-reference: UMLS_CUI:C0206672
alternative_term: Apocrine Cystadenoma
alternative_term: Apocrine cystadenoma
alternative_term: Eccrine Cystadenoma
alternative_term: Eccrine hidrocystoma of skin
alternative_term: Hidrocystoma
has_obo_namespace: disease_ontology
id: DOID:3893
in subset: NCIthesaurus

apocrine adenoma
type: Class
subclass of: apocrine sweat gland neoplasm
imported from: doid.owl
has cross-reference: NCI:C4168
has cross-reference: SNOMEDCT_US_2020_03_01:307596009
has cross-reference: UMLS_CUI:C0334345
alternative_term: tubular Apocrine adenoma
has_obo_namespace: disease_ontology
id: DOID:3895
in subset: NCIthesaurus

hidradenoma
type: Class
subclass of: cell type benign neoplasm
subclass of: sweat gland benign neoplasm
textual definition: A sweat gland benign neoplasm that is located_in an apical sweat gland.
imported from: doid.owl
has cross-reference: MESH:D006607
has cross-reference: NCI:C7560
has cross-reference: SNOMEDCT_US_2020_03_01:81393009
has cross-reference: UMLS_CUI:C0019522
alternative_term: Hidradenoma of skin
alternative_term: Sweat gland adenoma
alternative_term: Syringoadenoma
has_obo_namespace: disease_ontology
id: DOID:3896
in subset: NCIthesaurus

vulvitis
type: Class
subclass of: vulvar disease
textual definition: A vulvar disease that is characterized by inflammation of the vulva.
imported from: doid.owl
has cross-reference: ICD10CM:N76.2
has cross-reference: MESH:D014847
has cross-reference: SNOMEDCT_US_2020_03_01:63144007
has cross-reference: UMLS_CUI:C0042996
has_obo_namespace: disease_ontology
id: DOID:3901

bronchus carcinoma
type: Class
subclass of: bronchus cancer
subclass of: carcinoma
textual definition: A bronchus cancer that has_material_basis_in epithelial cells.
imported from: doid.owl
has cross-reference: MESH:D002283
has cross-reference: NCI:C35875
has cross-reference: SNOMEDCT_US_2020_03_01:254622008
has cross-reference: UMLS_CUI:C0007121
alternative_term: BC - Bronchogenic carcinoma
has_obo_namespace: disease_ontology
id: DOID:3904
in subset: DO cancer slim
in subset: NCIthesaurus

lung carcinoma
type: Class
subclass of: lung cancer
subclass of: carcinoma
textual definition: A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.
imported from: doid.owl
has cross-reference: EFO:0001071
has cross-reference: NCI:C4878
has cross-reference: SNOMEDCT_US_2020_03_01:154485001
has cross-reference: UMLS_CUI:C0684249
alternative_term: cancer of lung
has_obo_namespace: disease_ontology
has_related_synonym: carcinoma of lung
id: DOID:3905
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

bronchial benign neoplasm
type: Class
subclass of: respiratory system benign neoplasm
subclass of: bronchial disease
imported from: doid.owl
has cross-reference: MESH:D001984
has cross-reference: SNOMEDCT_US_2020_03_01:126705004
has cross-reference: UMLS_CUI:C0006264
alternative_term: bronchus neoplasm
alternative_term: neoplasm of bronchus
has_obo_namespace: disease_ontology
id: DOID:3906

lung squamous cell carcinoma
type: Class
subclass of: squamous cell carcinoma
subclass of: lung non-small cell carcinoma
textual definition: A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
imported from: doid.owl
has cross-reference: NCI:C3493
has cross-reference: SNOMEDCT_US_2020_03_01:254634000
has cross-reference: UMLS_CUI:C0149782
alternative_term: Epidermoid cell carcinoma of the lung
has_obo_namespace: disease_ontology
has_related_synonym: squamous cell carcinoma of lung
id: DOID:3907
in subset: DO cancer slim
in subset: NCIthesaurus

lung non-small cell carcinoma
type: Class
subclass of: lung carcinoma
textual definition: A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.
imported from: doid.owl
has cross-reference: EFO:0003060
has cross-reference: KEGG:05223
has cross-reference: MESH:D002289
has cross-reference: NCI:C2926
has cross-reference: SNOMEDCT_US_2020_03_01:254637007
has cross-reference: UMLS_CUI:C0007131
alternative_term: NSCLC
alternative_term: Non-small cell lung cancer
alternative_term: non-small cell lung carcinoma
has_obo_namespace: disease_ontology
id: DOID:3908
in subset: DO cancer slim
in subset: NCIthesaurus

progeria
type: Class
subclass of: autosomal genetic disease
subclass of: syndrome
textual definition: A syndrome characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble aged persons that has_material_basis_in mutation in LMNA on chromosome 1q22.
imported from: doid.owl
has cross-reference: GARD:7467
has cross-reference: ICD10CM:E34.8
has cross-reference: MEDDRA:10036794
has cross-reference: MESH:D011371
has cross-reference: NCI:C34951
has cross-reference: OMIM:176670
has cross-reference: ORDO:740
has cross-reference: SNOMEDCT_US_2020_03_01:190590004
has cross-reference: UMLS_CUI:C0033300
alternative_term: HGPS
alternative_term: Hutchinson Gilford syndrome
alternative_term: Hutchinson-Gilford Progeria syndrome
alternative_term: Hutchinson-Gilford disease
has_obo_namespace: disease_ontology
id: DOID:3911
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pancreatic cystadenoma
type: Class
subclass of: gastrointestinal system benign neoplasm
subclass of: pancreas disease
imported from: doid.owl
has cross-reference: NCI:C4374
has cross-reference: SNOMEDCT_US_2020_03_01:235967003
has cross-reference: UMLS_CUI:C0341486
has_obo_namespace: disease_ontology
id: DOID:3918
in subset: NCIthesaurus

diffuse lipomatosis
type: Class
subclass of: lipomatosis
imported from: doid.owl
has cross-reference: NCI:C6504
has cross-reference: UMLS_CUI:C1333298
has_obo_namespace: disease_ontology
id: DOID:3923
in subset: NCIthesaurus

pelvic lipomatosis
type: Class
subclass of: lipomatosis
imported from: doid.owl
has cross-reference: GARD:7350
has cross-reference: MESH:C535549
has cross-reference: NCI:C27486
has cross-reference: SNOMEDCT_US_2020_03_01:190802005
has cross-reference: UMLS_CUI:C0406608
has_obo_namespace: disease_ontology
id: DOID:3927
in subset: NCIthesaurus

otitis interna
type: Class
subclass of: inner ear disease
textual definition: An inner ear disease which involves inflammation of the inner ear.
imported from: doid.owl
has cross-reference: NCI:C27339
has cross-reference: UMLS_CUI:C1168225
alternative_term: inner ear infection
has_obo_namespace: disease_ontology
id: DOID:3930
in subset: NCIthesaurus

lipomatous cancer
type: Class
subclass of: connective tissue cancer
imported from: doid.owl
has cross-reference: NCI:C4501
has cross-reference: SNOMEDCT_US_2020_03_01:254828009
has cross-reference: UMLS_CUI:C0346117
alternative_term: malignant lipomatous tumor
alternative_term: malignant tumor of Adipose tissue
has_obo_namespace: disease_ontology
id: DOID:3939
in subset: NCIthesaurus

pituitary-dependent Cushing's disease
type: Class
subclass of: hyperpituitarism
imported from: doid.owl
has cross-reference: ICD10CM:E24.0
has cross-reference: MESH:D047748
has cross-reference: NCI:C113210
has cross-reference: SNOMEDCT_US_2020_03_01:190502001
has cross-reference: UMLS_CUI:C0221406
alternative_term: Overproduction of ACTH
alternative_term: pituitary-dependent Cushing disease
has_obo_namespace: disease_ontology
id: DOID:3946
in subset: NCIthesaurus

adrenal gland hyperfunction
type: Class
subclass of: DOID 9553
imported from: doid.owl
has cross-reference: MESH:D000308
has cross-reference: NCI:C113208
has cross-reference: SNOMEDCT_US_2020_03_01:47270006
has cross-reference: UMLS_CUI:C0001622
alternative_term: Adrenocortical hyperfunction
alternative_term: hyperadrenalism
alternative_term: hypercortisolism
has_obo_namespace: disease_ontology
id: DOID:3947
in subset: NCIthesaurus

adrenocortical carcinoma
type: Class
subclass of: carcinoma
subclass of: adrenal cortex cancer
textual definition: An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: GARD:558
has cross-reference: MESH:D018268
has cross-reference: NCI:C9325
has cross-reference: OMIM:202300
has cross-reference: SNOMEDCT_US_2020_03_01:255035007
has cross-reference: UMLS_CUI:C0206686
alternative_term: Adrenal cortical carcinoma
alternative_term: carcinoma of the Adrenal cortex
has_obo_namespace: disease_ontology
id: DOID:3948
in subset: DO cancer slim
in subset: NCIthesaurus

adrenal carcinoma
type: Class
subclass of: carcinoma
subclass of: adrenal gland cancer
textual definition: An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
alternative_term: carcinoma of the Adrenal gland
has_obo_namespace: disease_ontology
id: DOID:3950

acute myocarditis
type: Class
subclass of: myocarditis
imported from: doid.owl
has cross-reference: ICD10CM:I40
has cross-reference: ICD9CM:422
has cross-reference: NCI:C35206
has cross-reference: SNOMEDCT_US_2020_03_01:155336004
has cross-reference: UMLS_CUI:C0155686
has_obo_namespace: disease_ontology
id: DOID:3951
in subset: NCIthesaurus

adrenal cortex disease
type: Class
subclass of: DOID 9553
imported from: doid.owl
has cross-reference: MESH:D000303
has cross-reference: SNOMEDCT_US_2020_03_01:129636003
has cross-reference: UMLS_CUI:C0001614
has_obo_namespace: disease_ontology
id: DOID:3952

adrenal gland cancer
type: Class
subclass of: endocrine gland cancer
subclass of: DOID 9553
textual definition: An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.
imported from: doid.owl
has_alternative_id: DOID:11007
has cross-reference: GARD:5751
has cross-reference: ICD10CM:C74
has cross-reference: ICD9CM:194.0
has cross-reference: MESH:D000310
has cross-reference: NCI:C2859
has cross-reference: NCI:C9338
has cross-reference: SNOMEDCT_US_2020_03_01:127021009
has cross-reference: SNOMEDCT_US_2020_03_01:93665005
has cross-reference: UMLS_CUI:C0001624
has cross-reference: UMLS_CUI:C0750887
alternative_term: adrenal cancer
alternative_term: adrenal neoplasm
alternative_term: malignant Adrenal tumor
alternative_term: malignant neoplasm of adrenal gland
alternative_term: neoplasm of adrenal gland
alternative_term: tumor of the Adrenal gland
has_obo_namespace: disease_ontology
id: DOID:3953
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

thyroid gland carcinoma
type: Class
subclass of: thyroid gland cancer
subclass of: carcinoma
textual definition: A thyroid gland cancer that has_material_basis_in epithelial cells.
imported from: doid.owl
has cross-reference: EFO:0002892
has cross-reference: MESH:D013964
has cross-reference: NCI:C4815
has cross-reference: UMLS_CUI:C0549473
alternative_term: head and neck cancer, Thyroid
alternative_term: thyroid gland carcinoma
has_obo_namespace: disease_ontology
id: DOID:3963
in subset: DO cancer slim
in subset: NCIthesaurus

Merkel cell carcinoma
type: Class
subclass of: skin carcinoma
imported from: doid.owl
has cross-reference: GARD:9266
has cross-reference: NCI:C4068
has cross-reference: SNOMEDCT_US_2020_03_01:29792007
has cross-reference: UMLS_CUI:C0302182
alternative_term: Trabecular adenocarcinoma
alternative_term: trabecular carcinoma
has_obo_namespace: disease_ontology
id: DOID:3965
in subset: NCIthesaurus

thyroid gland papillary carcinoma
type: Class
subclass of: differentiated thyroid gland carcinoma
textual definition: A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer abd arises from the follicular cells of the thyroid gland.
imported from: doid.owl
has cross-reference: GARD:12027
has cross-reference: MESH:D000077273
has cross-reference: NCI:C4035
has cross-reference: OMIM:188550
has cross-reference: SNOMEDCT_US_2020_03_01:255029007
has cross-reference: UMLS_CUI:C0238463
alternative_term: Papillary carcinoma of the Thyroid gland
has_obo_namespace: disease_ontology
id: DOID:3969
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

restrictive cardiomyopathy
type: Class
subclass of: intrinsic cardiomyopathy
textual definition: An intrinsic cardiomyopathy characterized by impaired ventricular filling, with normal or decreased diastolic volume of either or both ventricles typically resulting from increased stiffness of the myocardium.
imported from: doid.owl
has cross-reference: ICD10CM:I42.5
has cross-reference: MESH:D002313
has cross-reference: NCI:C62798
has cross-reference: OMIM:115210
has cross-reference: OMIM:PS115210
has cross-reference: ORDO:75249
has cross-reference: SNOMEDCT_US_2020_03_01:389996009
has cross-reference: UMLS_CUI:C0007196
alternative_term: Cardiomyopathy, constrictive
alternative_term: Restrictive cardiomyopathy
alternative_term: primary restrictive cardiomyopathy
has_obo_namespace: disease_ontology
has_related_synonym: Familial restrictive cardiomyopathy
id: DOID:397
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mappings 115210, 612422 added from NeuroDevNet [WAK].

thyroid gland medullary carcinoma
type: Class
subclass of: thyroid gland carcinoma
textual definition: A thyroid gland carcinoma that has_material_basis_in parafollicular cells.
imported from: doid.owl
has cross-reference: MESH:C536914
has cross-reference: NCI:C3879
has cross-reference: SNOMEDCT_US_2020_03_01:255032005
has cross-reference: UMLS_CUI:C0238462
alternative_term: Medullary carcinoma of the Thyroid gland
alternative_term: Medullary thyroid carcinoma
alternative_term: Ultimobranchial thyroid tumor
alternative_term: Ultimobranchial thyroid tumour
alternative_term: medullary thyroid carcinoma
has_obo_namespace: disease_ontology
id: DOID:3973
in subset: DO cancer slim
in subset: NCIthesaurus

extrinsic cardiomyopathy
type: Class
subclass of: cardiomyopathy
textual definition: A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium.
imported from: doid.owl
has cross-reference: ICD9CM:425.8
has cross-reference: SNOMEDCT_US_2020_03_01:195580005
has cross-reference: UMLS_CUI:C0155699
has_obo_namespace: disease_ontology
id: DOID:3978

pantothenate kinase-associated neurodegeneration
type: Class
subclass of: autosomal recessive disease
subclass of: neurodegeneration with brain iron accumulation
textual definition: A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PANK2 gene on chromosome 20p13.
imported from: doid.owl
has cross-reference: GARD:6564
has cross-reference: ICD10CM:G23.0
has cross-reference: MESH:D006211
has cross-reference: NCI:C8967
has cross-reference: OMIM:234200
has cross-reference: ORDO:157850
has cross-reference: SNOMEDCT_US_2020_03_01:2992000
has cross-reference: UMLS_CUI:C0018523
alternative_term: Hallervorden-Spatz disease
alternative_term: Hallervorden-Spatz syndrome
alternative_term: NBIA1
alternative_term: Pigmentary pallidal degeneration
alternative_term: brain Iron Accumulation type I syndrome
alternative_term: neurodegeneration with brain iron accumulation 1
has_obo_namespace: disease_ontology
id: DOID:3981
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Meige syndrome
type: Class
subclass of: cranio-facial dystonia
textual definition: A cranio-facial dystonia that is accompanied by blepharospasm.
imported from: doid.owl
has cross-reference: GARD:7008
has cross-reference: MESH:D008538
has cross-reference: SNOMEDCT_US_2020_03_01:230325003
has cross-reference: UMLS_CUI:C0025183
has_obo_namespace: disease_ontology
id: DOID:3982

ostertagiasis
type: Class
subclass of: trichostrongyloidiasis
textual definition: A trichostrongyloidiasis that involves parasitic infection of the ruminant gastrointestinal tract by nematodes of the genus Ostertagia.
imported from: doid.owl
has cross-reference: MESH:D010029
has cross-reference: UMLS_CUI:C0029471
has_obo_namespace: disease_ontology
id: DOID:3985

tuberculosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
imported from: doid.owl
has_alternative_id: DOID:10096
has_alternative_id: DOID:12688
has_alternative_id: DOID:12691
has_alternative_id: DOID:415
has_alternative_id: DOID:9901
has_alternative_id: DOID:9902
has cross-reference: GARD:7827
has cross-reference: MESH:D014375
has cross-reference: SNOMEDCT_US_2020_03_01:15202009
has cross-reference: UMLS_CUI:C0041295
has_obo_namespace: disease_ontology
id: DOID:399
in subset: gram-positive bacterial infectious disease

urinary system cancer
type: Class
subclass of: organ system cancer
subclass of: urinary system disease
textual definition: An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.
imported from: doid.owl
has cross-reference: ICD10CM:C68.9
has cross-reference: ICD9CM:189.9
has cross-reference: SNOMEDCT_US_2020_03_01:448233000
has cross-reference: UMLS_CUI:C0348371
has_obo_namespace: disease_ontology
id: DOID:3996

disease
type: Class
textual definition: A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
imported from: doid.owl
has cross-reference: MESH:D004194
has cross-reference: NCI:C2991
has cross-reference: SNOMEDCT_US_2020_03_01:64572001
has cross-reference: UMLS_CUI:C0012634
has_obo_namespace: disease_ontology
id: DOID:4
in subset: NCIthesaurus

ovarian carcinoma
type: Class
subclass of: malignant ovarian surface epithelial-stromal neoplasm
textual definition: An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary.
imported from: doid.owl
has cross-reference: EFO:0001075
has cross-reference: UMLS_CUI:C0677886
alternative_term: Ovarian carcinoma
has_obo_namespace: disease_ontology
id: DOID:4001
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

bladder urothelial carcinoma
type: Class
subclass of: transitional cell carcinoma
subclass of: bladder carcinoma
textual definition: A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder.
imported from: doid.owl
has cross-reference: NCI:C39851
has cross-reference: SNOMEDCT_US_2020_03_01:393562002
has cross-reference: UMLS_CUI:C0279680
alternative_term: bladder transitional cell carcinoma
alternative_term: transitional cell carcinoma of bladder
alternative_term: urinary bladder urothelial carcinoma
alternative_term: urothelial bladder carcinoma
has_obo_namespace: disease_ontology
id: DOID:4006
in subset: DO cancer slim
in subset: NCIthesaurus

bladder carcinoma
type: Class
subclass of: urinary bladder cancer
subclass of: carcinoma
textual definition: A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: EFO:0000292
has cross-reference: NCI:C4912
has cross-reference: SNOMEDCT_US_2020_03_01:269607003
has cross-reference: UMLS_CUI:C0699885
alternative_term: carcinoma of urinary bladder
has_obo_namespace: disease_ontology
id: DOID:4007
in subset: DO cancer slim
in subset: NCIthesaurus

multidrug-resistant tuberculosis
type: Class
subclass of: tuberculosis
textual definition: A tuberculosis that is resistant to isoniazid and rifampicin, the two most powerful first-line anti-TB drugs.
imported from: doid.owl
has cross-reference: MESH:D018088
has cross-reference: NCI:C128415
has cross-reference: SNOMEDCT_US_2020_03_01:423092005
has cross-reference: UMLS_CUI:C0206526
has_obo_namespace: disease_ontology
id: DOID:401
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

papillary transitional carcinoma
type: Class
subclass of: transitional cell carcinoma
textual definition: A transitional cell carcinoma that has several papillary fronds with central fibrovascular core lined by transitional type epithelium.
imported from: doid.owl
has cross-reference: NCI:C4122
has cross-reference: SNOMEDCT_US_2020_03_01:12400006
has cross-reference: UMLS_CUI:C0334274
alternative_term: Papillary transitional cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:4012
in subset: NCIthesaurus

ureterocele
type: Class
subclass of: ureteral disease
textual definition: A ureteral disease that is characterized_as a congenital anomaly in which the distal end of the ureter swells as it enters the bladder.
imported from: doid.owl
has cross-reference: MESH:D014518
has cross-reference: NCI:C123159
has cross-reference: OMIM:191650
has cross-reference: SNOMEDCT_US_2020_03_01:12818004
has cross-reference: UMLS_CUI:C0041960
has_obo_namespace: disease_ontology
id: DOID:4022
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

angioma serpiginosum
type: Class
subclass of: skin hemangioma
textual definition: A skin hemangioma that is characterized by the presence of small red dots that cluster together to form a linear or snake-like array or ring-shaped pattern located_in the blood vessels of the skin.
imported from: doid.owl
has cross-reference: ICD10CM:L81.7
has cross-reference: NCI:C3926
has cross-reference: OMIM:106050
has cross-reference: OMIM:300652
has cross-reference: ORDO:95429
has cross-reference: SNOMEDCT_US_2020_03_01:49465005
has cross-reference: UMLS_CUI:C0263637
alternative_term: Angioma serpiginosum of skin
has_obo_namespace: disease_ontology
id: DOID:4028
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

gastritis
type: Class
subclass of: stomach disease
textual definition: A stomach disease that is an inflammation of the lining of the stomach.
imported from: doid.owl
has_alternative_id: DOID:4032
has_alternative_id: DOID:8697
has_alternative_id: DOID:8845
has_alternative_id: DOID:9190
has cross-reference: ICD10CM:K29.7
has cross-reference: MESH:D005756
has cross-reference: NCI:C26780
has cross-reference: SNOMEDCT_US_2020_03_01:155711008
has cross-reference: UMLS_CUI:C0017152
alternative_term: Erosive Gastritis
alternative_term: Erosive gastropathy
alternative_term: acute gastric mucosal erosion
has_obo_namespace: disease_ontology
id: DOID:4029
in subset: NCIthesaurus

mouth disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the mouth.
imported from: doid.owl
has cross-reference: MESH:D009059
has cross-reference: NCI:C27641
has cross-reference: SNOMEDCT_US_2020_03_01:118938008
has cross-reference: UMLS_CUI:C0026636
has_obo_namespace: disease_ontology
id: DOID:403
in subset: NCIthesaurus

eosinophilic gastroenteritis
type: Class
subclass of: gastroenteritis
imported from: doid.owl
has cross-reference: ICD9CM:558.41
has cross-reference: NCI:C35330
has cross-reference: SNOMEDCT_US_2020_03_01:359804008
has cross-reference: UMLS_CUI:C1262481
alternative_term: Eosinophilic Gastroenteritis
alternative_term: Eosinophilic gastroenteritis
has_obo_namespace: disease_ontology
id: DOID:4031
in subset: NCIthesaurus

lymphocytic gastritis
type: Class
subclass of: gastritis
imported from: doid.owl
has cross-reference: NCI:C27051
has cross-reference: SNOMEDCT_US_2020_03_01:235658000
has cross-reference: UMLS_CUI:C1283271
has_obo_namespace: disease_ontology
id: DOID:4035
in subset: NCIthesaurus

gastrointestinal tuberculosis
type: Class
subclass of: abdominal tuberculosis
textual definition: An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.
imported from: doid.owl
has_alternative_id: DOID:9802
has cross-reference: MESH:D014385
has cross-reference: SNOMEDCT_US_2020_03_01:154286002
has cross-reference: UMLS_CUI:C0041312
alternative_term: Tuberculosis of gastrointestinal tract
alternative_term: Tuberculosis of intestines, peritoneum and mesenteric glands
alternative_term: Tuberculosis of intestines, peritoneum, and mesenteric glands
alternative_term: tuberculosis of intestines, peritoneum and mesenteric glands
has_obo_namespace: disease_ontology
id: DOID:404
in subset: gram-positive bacterial infectious disease

skeletal muscle cancer
type: Class
subclass of: muscle cancer
imported from: doid.owl
has cross-reference: NCI:C6516
has cross-reference: UMLS_CUI:C1334619
alternative_term: malignant tumor of Skeletal Muscle
has_obo_namespace: disease_ontology
id: DOID:4043
in subset: NCIthesaurus

skeletal muscle neoplasm
type: Class
subclass of: muscle benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C6514
has cross-reference: SNOMEDCT_US_2020_03_01:699955004
has cross-reference: UMLS_CUI:C1335971
alternative_term: tumor of Skeletal Muscle
has_obo_namespace: disease_ontology
id: DOID:4044
in subset: NCIthesaurus

muscle cancer
type: Class
subclass of: musculoskeletal system cancer
subclass of: muscular disease
textual definition: A musculoskeletal system cancer that is located_in muscle.
imported from: doid.owl
has_alternative_id: DOID:4046
has cross-reference: ICD10CM:C49
has cross-reference: MESH:D009217
has cross-reference: MESH:D019042
has cross-reference: NCI:C4883
has cross-reference: SNOMEDCT_US_2020_03_01:20667008
has cross-reference: SNOMEDCT_US_2020_03_01:93913006
has cross-reference: UMLS_CUI:C0027095
has cross-reference: UMLS_CUI:C0684743
alternative_term: malignant neoplasm of muscle
alternative_term: malignant tumor of muscle
alternative_term: malignant tumor of the Muscle
alternative_term: myosarcoma
has_obo_namespace: disease_ontology
id: DOID:4045
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

alveolar rhabdomyosarcoma
type: Class
subclass of: rhabdomyosarcoma
imported from: doid.owl
has_alternative_id: DOID:4382
has cross-reference: GARD:4701
has cross-reference: MESH:D018232
has cross-reference: NCI:C3749
has cross-reference: NCI:C7958
has cross-reference: OMIM:268220
has cross-reference: SNOMEDCT_US_2020_03_01:404053004
has cross-reference: UMLS_CUI:C0206655
has cross-reference: UMLS_CUI:C0279613
alternative_term: Alveolar rhabdomyosarcoma
alternative_term: alveolar childhood rhabdomyosarcoma
has_obo_namespace: disease_ontology
id: DOID:4051
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

prostate sarcoma
type: Class
subclass of: prostate cancer
subclass of: sarcoma
textual definition: A prostate cancer that is located_in the prostate.
imported from: doid.owl
has cross-reference: NCI:C7731
has cross-reference: UMLS_CUI:C0238393
alternative_term: sarcoma of the prostate
has_obo_namespace: disease_ontology
id: DOID:4054
in subset: NCIthesaurus

ectomesenchymoma
type: Class
subclass of: central nervous system mesenchymal non-meningothelial tumor
imported from: doid.owl
has cross-reference: NCI:C4716
has cross-reference: SNOMEDCT_US_2020_03_01:128750008
has cross-reference: UMLS_CUI:C0431111
alternative_term: Rhabdomyosarcoma with ganglionic differentiation
has_obo_namespace: disease_ontology
id: DOID:4055
in subset: NCIthesaurus

duodenogastric reflux
type: Class
subclass of: duodenum disease
imported from: doid.owl
has cross-reference: MESH:D004383
has cross-reference: SNOMEDCT_US_2020_03_01:9733003
has cross-reference: UMLS_CUI:C0013299
alternative_term: Duodenogastric reflux
has_obo_namespace: disease_ontology
id: DOID:4071

duodenum disease
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: MESH:D004378
has cross-reference: SNOMEDCT_US_2020_03_01:196598004
has cross-reference: UMLS_CUI:C0013289
alternative_term: duodenal disease
alternative_term: duodenum disorder
has_obo_namespace: disease_ontology
id: DOID:4072

pancreatic cystadenocarcinoma
type: Class
subclass of: pancreatic adenocarcinoma
imported from: doid.owl
has cross-reference: NCI:C3874
has cross-reference: SNOMEDCT_US_2020_03_01:235966007
has cross-reference: UMLS_CUI:C0238337
alternative_term: cystadenocarcinoma of pancreas
has_obo_namespace: disease_ontology
id: DOID:4073
in subset: NCIthesaurus

pancreatic adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: pancreatic carcinoma
textual definition: A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C8294
has cross-reference: SNOMEDCT_US_2020_03_01:700423003
has cross-reference: UMLS_CUI:C0281361
alternative_term: pancreas adenocarcinoma
has_obo_namespace: disease_ontology
has_related_synonym: adenocarcinoma of the pancreas
id: DOID:4074
in subset: DO cancer slim
in subset: NCIthesaurus

tricuspid valve stenosis
type: Class
subclass of: tricuspid valve disease
textual definition: A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve.
imported from: doid.owl
has cross-reference: MESH:D014264
has cross-reference: NCI:C50783
has cross-reference: SNOMEDCT_US_2020_03_01:49915006
has cross-reference: UMLS_CUI:C0040963
alternative_term: Tricuspid stenosis
has_obo_namespace: disease_ontology
id: DOID:4078
in subset: NCIthesaurus

heart valve disease
type: Class
subclass of: heart disease
textual definition: A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right).
imported from: doid.owl
has_alternative_id: DOID:989
has cross-reference: MESH:D006349
has cross-reference: MESH:D016127
has cross-reference: NCI:C45525
has cross-reference: SNOMEDCT_US_2020_03_01:368009
has cross-reference: SNOMEDCT_US_2020_03_01:398995000
has cross-reference: UMLS_CUI:C0018824
has cross-reference: UMLS_CUI:C0079485
alternative_term: Valvular heart disease
has_obo_namespace: disease_ontology
id: DOID:4079
in subset: NCIthesaurus

tricuspid valve insufficiency
type: Class
subclass of: tricuspid valve disease
textual definition: A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.
imported from: doid.owl
has cross-reference: MESH:D014262
has cross-reference: NCI:C50842
has cross-reference: SNOMEDCT_US_2020_03_01:111287006
has cross-reference: UMLS_CUI:C0040961
alternative_term: Tricuspid incompetence
alternative_term: Tricuspid regurgitation
alternative_term: Tricuspid valve regurgitation
has_obo_namespace: disease_ontology
id: DOID:4080
in subset: NCIthesaurus

trophoblastic neoplasm
type: Class
subclass of: germ cell and embryonal cancer
textual definition: A germ cell and embryonal cancer that derives_from trophoblastic tissue.
imported from: doid.owl
has cross-reference: MESH:D014328
has cross-reference: NCI:C3422
has cross-reference: SNOMEDCT_US_2020_03_01:115234004
has cross-reference: UMLS_CUI:C0041182
alternative_term: Trophoblastic neoplasm
alternative_term: Trophoblastic tumor
has_obo_namespace: disease_ontology
id: DOID:4085
in subset: NCIthesaurus

liver disease
type: Class
subclass of: hepatobiliary disease
imported from: doid.owl
has_alternative_id: DOID:2164
has_alternative_id: DOID:2165
has_alternative_id: DOID:46
has cross-reference: ICD10CM:K76.9
has cross-reference: ICD9CM:573.9
has cross-reference: MESH:D008107
has cross-reference: NCI:C3196
has cross-reference: SNOMEDCT_US_2020_03_01:62857009
has cross-reference: UMLS_CUI:C0023895
alternative_term: disorder of liver
alternative_term: hepatic disorder
has_obo_namespace: disease_ontology
id: DOID:409
in subset: NCIthesaurus

agnosia
type: Class
subclass of: communication disorder
textual definition: A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.
imported from: doid.owl
has_alternative_id: DOID:4019
has cross-reference: GARD:8
has cross-reference: ICD10CM:R48.1
has cross-reference: MESH:D000377
has cross-reference: NCI:C84542
has cross-reference: SNOMEDCT_US_2020_03_01:42341009
has cross-reference: UMLS_CUI:C0001816
alternative_term: Dyspraxia
alternative_term: Dyspraxia syndrome
has_obo_namespace: disease_ontology
id: DOID:4090
in subset: NCIthesaurus

tick infestation
type: Class
subclass of: parasitic ectoparasitic infectious disease
textual definition: A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice.
imported from: doid.owl
has cross-reference: MESH:D013984
has cross-reference: UMLS_CUI:C0040196
has_obo_namespace: disease_ontology
id: DOID:4109

parasitic ectoparasitic infectious disease
type: Class
subclass of: parasitic infectious disease
textual definition: A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host.
imported from: doid.owl
has cross-reference: MESH:D004478
has cross-reference: UMLS_CUI:C0013578
alternative_term: ectoparasitism
has_obo_namespace: disease_ontology
id: DOID:4110

nail disease
type: Class
subclass of: integumentary system disease
textual definition: An integumentary system disease that is located_in nail.
imported from: doid.owl
has cross-reference: ICD10CM:L60
has cross-reference: ICD9CM:703
has cross-reference: MESH:D009260
has cross-reference: SNOMEDCT_US_2020_03_01:17790008
has cross-reference: UMLS_CUI:C0027339
has_obo_namespace: disease_ontology
id: DOID:4123

common bile duct disease
type: Class
subclass of: bile duct disease
imported from: doid.owl
has cross-reference: MESH:D003137
has cross-reference: UMLS_CUI:C0009440
has_obo_namespace: disease_ontology
id: DOID:4137

bile duct disease
type: Class
subclass of: DOID 9741
imported from: doid.owl
has cross-reference: MESH:D001649
has cross-reference: NCI:C96716
has cross-reference: SNOMEDCT_US_2020_03_01:118926004
has cross-reference: UMLS_CUI:C0005395
alternative_term: bile duct disorder
alternative_term: disorder of bile duct
has_obo_namespace: disease_ontology
id: DOID:4138
in subset: NCIthesaurus

biliary dyskinesia
type: Class
subclass of: gallbladder disease
textual definition: A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree.
imported from: doid.owl
has_alternative_id: DOID:4139
has cross-reference: MESH:D001657
has cross-reference: SNOMEDCT_US_2020_03_01:43469007
has cross-reference: UMLS_CUI:C0005416
alternative_term: sphincter of oddi dysfunction
has_obo_namespace: disease_ontology
id: DOID:4140

orbital cancer
type: Class
subclass of: bone cancer
subclass of: DOID 930
textual definition: A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.
imported from: doid.owl
has_alternative_id: DOID:9984
has cross-reference: ICD10CM:C69.6
has cross-reference: ICD9CM:190.1
has cross-reference: MESH:D009918
has cross-reference: NCI:C3290
has cross-reference: NCI:C3562
has cross-reference: SNOMEDCT_US_2020_03_01:127003006
has cross-reference: SNOMEDCT_US_2020_03_01:363462005
has cross-reference: UMLS_CUI:C0029185
has cross-reference: UMLS_CUI:C0153626
alternative_term: malignant neoplasm of orbit
alternative_term: neoplasm of orbit proper
alternative_term: orbit cancer
alternative_term: orbital tumor
has_obo_namespace: disease_ontology
id: DOID:4143
in subset: NCIthesaurus

dentinogenesis imperfecta
type: Class
subclass of: tooth disease
imported from: doid.owl
has cross-reference: GARD:6258
has cross-reference: ICD10CM:K00.5
has cross-reference: MESH:D003811
has cross-reference: NCI:C84667
has cross-reference: OMIM:125490
has cross-reference: OMIM:125500
has cross-reference: ORDO:49042
has cross-reference: SNOMEDCT_US_2020_03_01:367461002
has cross-reference: UMLS_CUI:C0011436
has_obo_namespace: disease_ontology
id: DOID:4154
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

primary syphilis
type: Class
subclass of: syphilis
textual definition: A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes.
imported from: doid.owl
has cross-reference: ICD9CM:091
has cross-reference: SNOMEDCT_US_2020_03_01:186846005
has cross-reference: UMLS_CUI:C0153139
alternative_term: Symptomatic early syphilis
alternative_term: early symptomatic syphilis
alternative_term: early syphilis, symptomatic
has_obo_namespace: disease_ontology
id: DOID:4156
in subset: gram-negative bacterial infectious disease
in subset: sexually transmitted infectious disease

skin cancer
type: Class
subclass of: integumentary system cancer
subclass of: skin disease
textual definition: An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.
imported from: doid.owl
has cross-reference: GARD:10421
has cross-reference: MESH:D012878
has cross-reference: NCI:C2920
has cross-reference: SNOMEDCT_US_2020_03_01:94047004
has cross-reference: UMLS_CUI:C0007114
alternative_term: CA - skin cancer
alternative_term: malignant neoplasm of skin
alternative_term: melanoma and Non-melanoma skin cancer
has_obo_namespace: disease_ontology
has_related_synonym: cancer of skin
id: DOID:4159
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

differentiating neuroblastoma
type: Class
subclass of: neuroblastoma
imported from: doid.owl
has cross-reference: NCI:C42048
has cross-reference: UMLS_CUI:C1511934
has_obo_namespace: disease_ontology
id: DOID:4160
in subset: NCIthesaurus

ganglioneuroblastoma
type: Class
subclass of: neuroblastoma
imported from: doid.owl
has cross-reference: MESH:D018305
has cross-reference: NCI:C3790
has cross-reference: SNOMEDCT_US_2020_03_01:116381000119105
has cross-reference: UMLS_CUI:C0206718
alternative_term: Ganglioneuroblastoma
has_obo_namespace: disease_ontology
id: DOID:4163
in subset: NCIthesaurus

syphilis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.
imported from: doid.owl
has_alternative_id: DOID:11095
has cross-reference: ICD10CM:A51.0
has cross-reference: MESH:D002601
has cross-reference: SNOMEDCT_US_2020_03_01:736686006
has cross-reference: UMLS_CUI:C0007939
alternative_term: syphilitic chancre
has_obo_namespace: disease_ontology
id: DOID:4166
in subset: gram-negative bacterial infectious disease
in subset: sexually transmitted infectious disease

autoimmune disease
type: Class
subclass of: primary immunodeficiency disease
textual definition: An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.
imported from: doid.owl
IEDB alternative term: autoimmune disease
has cross-reference: ICD9CM:720
has cross-reference: OMIM:109100
has cross-reference: UMLS_CUI:C0003089
alternative_term: autoimmune hypersensitivity disease
alternative_term: hypersensitivity reaction type II disease
has_obo_namespace: disease_ontology
id: DOID:417
comment: Xref MGI.

Rh isoimmunization
type: Class
subclass of: blood group incompatibility
imported from: doid.owl
has cross-reference: MESH:D012203
has cross-reference: NCI:C113150
has cross-reference: SNOMEDCT_US_2020_03_01:199580004
has cross-reference: UMLS_CUI:C0035404
alternative_term: Rh incompatibility affecting management of mother
has_obo_namespace: disease_ontology
id: DOID:4175
in subset: NCIthesaurus

blood group incompatibility
type: Class
subclass of: hematopoietic system disease
imported from: doid.owl
has cross-reference: MESH:D001787
has cross-reference: UMLS_CUI:C0005806
has_obo_namespace: disease_ontology
id: DOID:4176

systemic scleroderma
type: Class
subclass of: scleroderma
textual definition: A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.
imported from: doid.owl
has cross-reference: EFO:0000717
has cross-reference: GARD:9748
has cross-reference: ICD10CM:M34.0
has cross-reference: ICD9CM:710.1
has cross-reference: MESH:D012595
has cross-reference: NCI:C72070
has cross-reference: OMIM:181750
has cross-reference: SNOMEDCT_US_2020_03_01:89155008
has cross-reference: UMLS_CUI:C0036421
alternative_term: Scleroderma
alternative_term: Scleroderma syndrome
alternative_term: progressive systemic sclerosis
alternative_term: systemic sclerosis
has_obo_namespace: disease_ontology
id: DOID:418
in subset: NCIthesaurus

pseudopseudohypoparathyroidism
type: Class
subclass of: pseudohypoparathyroidism
imported from: doid.owl
has cross-reference: GARD:7860
has cross-reference: MESH:D011556
has cross-reference: NCI:C129722
has cross-reference: OMIM:612463
has cross-reference: SNOMEDCT_US_2020_03_01:190867002
has cross-reference: UMLS_CUI:C0033835
alternative_term: Normocalcemic pseudohypoparathyroidism
alternative_term: Pseudopseudohypoparathyroidism
has_obo_namespace: disease_ontology
id: DOID:4183
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pseudohypoparathyroidism
type: Class
subclass of: DOID 896
imported from: doid.owl
has cross-reference: GARD:10758
has cross-reference: ICD10CM:E20.1
has cross-reference: MESH:D011547
has cross-reference: NCI:C99027
has cross-reference: OMIM:612462
has cross-reference: SNOMEDCT_US_2020_03_01:190867002
has cross-reference: UMLS_CUI:C0033806
has_obo_namespace: disease_ontology
id: DOID:4184
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

articulation disorder
type: Class
subclass of: DOID 92
textual definition: A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.
imported from: doid.owl
has cross-reference: MESH:D001184
has cross-reference: SNOMEDCT_US_2020_03_01:8187005
has cross-reference: UMLS_CUI:C0003910
alternative_term: Articulation impairment
alternative_term: Phonological disorder
has_obo_namespace: disease_ontology
id: DOID:4186

mutism
type: Class
subclass of: DOID 92
textual definition: A speech disorder that involves a complete inability to speak.
imported from: doid.owl
has cross-reference: MESH:D009155
has cross-reference: SNOMEDCT_US_2020_03_01:267771000
has cross-reference: UMLS_CUI:C0026884
has_obo_namespace: disease_ontology
id: DOID:4189

scleroderma
type: Class
subclass of: rheumatic disease
textual definition: A rheumatic disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs.
imported from: doid.owl
has cross-reference: MESH:D012594
has cross-reference: NCI:C26746
has cross-reference: SNOMEDCT_US_2020_03_01:201440007
has cross-reference: UMLS_CUI:C0011644
alternative_term: dermatosclerosis
has_obo_namespace: disease_ontology
id: DOID:419
in subset: NCIthesaurus

intracranial thrombosis
type: Class
subclass of: thrombosis
subclass of: cerebrovascular disease
imported from: doid.owl
has_alternative_id: DOID:12751
has cross-reference: ICD9CM:434.0
has cross-reference: MESH:D020767
has cross-reference: SNOMEDCT_US_2020_03_01:155401002
has cross-reference: UMLS_CUI:C0079102
has cross-reference: UMLS_CUI:C0752143
alternative_term: cerebral thrombosis
has_obo_namespace: disease_ontology
id: DOID:4193

glucose metabolism disease
type: Class
subclass of: carbohydrate metabolism disease
imported from: doid.owl
has cross-reference: MESH:D044882
has cross-reference: NCI:C53655
has cross-reference: SNOMEDCT_US_2020_03_01:126877002
has cross-reference: UMLS_CUI:C1257958
alternative_term: disorder of glucose metabolism
has_obo_namespace: disease_ontology
id: DOID:4194
in subset: NCIthesaurus

hyperglycemia
type: Class
subclass of: glucose metabolism disease
imported from: doid.owl
has cross-reference: ICD10CM:R73.9
has cross-reference: MESH:D006943
has cross-reference: NCI:C26797
has cross-reference: SNOMEDCT_US_2020_03_01:144187006
has cross-reference: UMLS_CUI:C0020456
has_obo_namespace: disease_ontology
id: DOID:4195
in subset: NCIthesaurus

hypertrichosis
type: Class
subclass of: hair disease
textual definition: A hair disease characterized by hair growth that is abnormal in quantity or location.
imported from: doid.owl
has cross-reference: ICD10CM:L68
has cross-reference: MESH:D006983
has cross-reference: NCI:C79597
has cross-reference: ORDO:79365
has cross-reference: SNOMEDCT_US_2020_03_01:201164001
has cross-reference: UMLS_CUI:C0020555
has_obo_namespace: disease_ontology
id: DOID:420
in subset: NCIthesaurus

peroneal neuropathy
type: Class
subclass of: mononeuropathy
imported from: doid.owl
has cross-reference: MESH:D020427
has cross-reference: NCI:C27596
has cross-reference: UMLS_CUI:C0747533
alternative_term: Peroneal Neuropathy
has_obo_namespace: disease_ontology
id: DOID:4201
in subset: NCIthesaurus

brain stem glioma
type: Class
subclass of: malignant glioma
subclass of: brain stem cancer
textual definition: A brain stem cancer that is characterized by mass lesion of the brainstem, associated cranial nerve nuclei and long tracts, has_material_basis_in abnormally proliferating cells, derives_from glial cells.
imported from: doid.owl
has cross-reference: NCI:C8501
has cross-reference: SNOMEDCT_US_2020_03_01:444545003
has cross-reference: UMLS_CUI:C0677865
alternative_term: Brainstem Neuroglial tumor
has_obo_namespace: disease_ontology
id: DOID:4202
in subset: NCIthesaurus

brain stem cancer
type: Class
subclass of: infratentorial cancer
imported from: doid.owl
has_alternative_id: DOID:13974
has_alternative_id: DOID:4204
has_alternative_id: DOID:4208
has cross-reference: GARD:8244
has cross-reference: ICD10CM:C71.7
has cross-reference: ICD9CM:191.7
has cross-reference: MESH:D020295
has cross-reference: NCI:C3570
has cross-reference: NCI:C4869
has cross-reference: NCI:C4975
has cross-reference: NCI:C5967
has cross-reference: SNOMEDCT_US_2020_03_01:126961004
has cross-reference: SNOMEDCT_US_2020_03_01:93726004
has cross-reference: UMLS_CUI:C0153641
has cross-reference: UMLS_CUI:C0677866
has cross-reference: UMLS_CUI:C0751886
has cross-reference: UMLS_CUI:C1332192
alternative_term: malignant neoplasm of brain stem
alternative_term: malignant neoplasm of brainstem
alternative_term: neoplasm of adult brain stem
alternative_term: neoplasm of brain stem
alternative_term: primary brain Stem tumor
alternative_term: primary brain stem neoplasm
has_obo_namespace: disease_ontology
id: DOID:4203
in subset: NCIthesaurus

cerebellum cancer
type: Class
subclass of: cerebellar disease
subclass of: infratentorial cancer
imported from: doid.owl
has_alternative_id: DOID:12786
has cross-reference: ICD10CM:C71.6
has cross-reference: ICD9CM:191.6
has cross-reference: MESH:D002528
has cross-reference: NCI:C2935
has cross-reference: NCI:C3569
has cross-reference: SNOMEDCT_US_2020_03_01:126960003
has cross-reference: SNOMEDCT_US_2020_03_01:449420002
has cross-reference: UMLS_CUI:C0007762
has cross-reference: UMLS_CUI:C0153640
alternative_term: cerebellar cancer
alternative_term: malignant tumor of Cerebellum
has_obo_namespace: disease_ontology
id: DOID:4205
in subset: NCIthesaurus

hair disease
type: Class
subclass of: integumentary system disease
textual definition: An integumentary system disease that is located_in hair.
imported from: doid.owl
has cross-reference: MESH:D006201
has cross-reference: NCI:C34656
has cross-reference: SNOMEDCT_US_2020_03_01:267862002
has cross-reference: UMLS_CUI:C0018500
has_obo_namespace: disease_ontology
id: DOID:421
in subset: NCIthesaurus

malignant ovarian Brenner tumor
type: Class
subclass of: malignant ovarian surface epithelial-stromal neoplasm
textual definition: A malignant ovarian surface epithelial-stromal neoplasm that has_material_basis_in the surface epithelium of the ovary.
imported from: doid.owl
has cross-reference: MESH:D001948
has cross-reference: NCI:C4270
has cross-reference: SNOMEDCT_US_2020_03_01:42194009
has cross-reference: UMLS_CUI:C0334495
has_obo_namespace: disease_ontology
id: DOID:4217
in subset: NCIthesaurus

congenital structural myopathy
type: Class
subclass of: physical disorder
subclass of: myopathy
imported from: doid.owl
has cross-reference: MESH:D020914
has cross-reference: NCI:C84648
has cross-reference: UMLS_CUI:C0752282
has_obo_namespace: disease_ontology
id: DOID:422
in subset: DO FlyBase slim
in subset: NCIthesaurus

pyoderma
type: Class
subclass of: dermatitis
textual definition: A dermatitis that is characterized by a pyogenic infection causing the formation of pus.
imported from: doid.owl
has cross-reference: ICD10CM:L08.0
has cross-reference: ICD9CM:686.0
has cross-reference: MESH:D011711
has cross-reference: SNOMEDCT_US_2020_03_01:267838007
has cross-reference: UMLS_CUI:C0034212
has_obo_namespace: disease_ontology
id: DOID:4223

endometrial stromal sarcoma
type: Class
subclass of: endometrial stromal tumor
textual definition: An endometrial stromal tumor that has_material_basis in connective tissue.
imported from: doid.owl
has cross-reference: GARD:6339
has cross-reference: MESH:D018203
has cross-reference: NCI:C8973
has cross-reference: SNOMEDCT_US_2020_03_01:70555003
has cross-reference: UMLS_CUI:C0206630
alternative_term: ESS
alternative_term: Undifferentiated endometrial sarcoma
alternative_term: endometrial stromal sarcoma, high grade
has_obo_namespace: disease_ontology
id: DOID:4226
in subset: DO cancer slim
in subset: NCIthesaurus

myopathy
type: Class
subclass of: muscle tissue disease
textual definition: A muscular disease in which the muscle fibers do not function resulting in muscular weakness.
imported from: doid.owl
has cross-reference: ICD10CM:G72.9
has cross-reference: ICD9CM:359.9
has cross-reference: MESH:D009135
has cross-reference: NCI:C101216
has cross-reference: SNOMEDCT_US_2020_03_01:155094005
has cross-reference: UMLS_CUI:C0026848
has_obo_namespace: disease_ontology
id: DOID:423
in subset: DO FlyBase slim
in subset: NCIthesaurus

smooth muscle cancer
type: Class
subclass of: muscle cancer
imported from: doid.owl
has cross-reference: NCI:C6511
has cross-reference: UMLS_CUI:C1334620
alternative_term: malignant tumor of Smooth Muscle
has_obo_namespace: disease_ontology
id: DOID:4230
in subset: NCIthesaurus

histiocytoma
type: Class
subclass of: connective tissue benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D051642
has cross-reference: NCI:C35765
has cross-reference: SNOMEDCT_US_2020_03_01:154614002
has cross-reference: UMLS_CUI:C1509147
has_obo_namespace: disease_ontology
id: DOID:4231
in subset: NCIthesaurus

extraosseous Ewing sarcoma
type: Class
subclass of: Ewing sarcoma
textual definition: A Ewing sarcoma that is morphologically indistinguishable from skeletal Ewing sarcoma but is located in extraosseous locations.
imported from: doid.owl
has cross-reference: NCI:C27293
has cross-reference: ORDO:370334
has cross-reference: UMLS_CUI:C1333514
alternative_term: extraosseous Ewing's sarcoma
alternative_term: extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumor
alternative_term: extraskeletal Ewing sarcom
has_obo_namespace: disease_ontology
id: DOID:4232
in subset: NCIthesaurus

clear cell sarcoma
type: Class
subclass of: sarcoma
textual definition: A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.
imported from: doid.owl
has_alternative_id: DOID:4881
has cross-reference: MESH:D018227
has cross-reference: NCI:C27370
has cross-reference: NCI:C3745
has cross-reference: SNOMEDCT_US_2020_03_01:12622007
has cross-reference: UMLS_CUI:C0206651
has cross-reference: UMLS_CUI:C1332198
alternative_term: Clear cell sarcoma
alternative_term: Clear cell sarcoma of soft Parts
alternative_term: adult soft part clear cell sarcoma
alternative_term: malignant melanoma of soft tissues
alternative_term: melanoma, malignant, of soft parts
has_obo_namespace: disease_ontology
has_related_synonym: malignant melanoma of soft parts
id: DOID:4233
in subset: NCIthesaurus

spindle cell sarcoma
type: Class
subclass of: sarcoma
textual definition: A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy.
imported from: doid.owl
has cross-reference: MESH:D012509
has cross-reference: NCI:C27005
has cross-reference: SNOMEDCT_US_2020_03_01:9801004
has cross-reference: UMLS_CUI:C0205945
has_obo_namespace: disease_ontology
id: DOID:4235
in subset: NCIthesaurus

carcinosarcoma
type: Class
subclass of: mixed cell type cancer
textual definition: A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.
imported from: doid.owl
has_alternative_id: DOID:1971
has_alternative_id: DOID:2610
has_alternative_id: DOID:4234
has cross-reference: MESH:D002296
has cross-reference: MESH:D018199
has cross-reference: MESH:D018200
has cross-reference: NCI:C34448
has cross-reference: NCI:C3730
has cross-reference: NCI:C8975
has cross-reference: SNOMEDCT_US_2020_03_01:112684005
has cross-reference: SNOMEDCT_US_2020_03_01:63264007
has cross-reference: SNOMEDCT_US_2020_03_01:84427001
has cross-reference: UMLS_CUI:C0007140
has cross-reference: UMLS_CUI:C0206627
has cross-reference: UMLS_CUI:C1334603
alternative_term: MMMT
alternative_term: Mesodermal mixed tumor
alternative_term: malignant mixed Mullerian tumor
alternative_term: malignant mixed mesodermal (mullerian) tumor
alternative_term: mesodermal mixed tumor
alternative_term: mixed Mesodermal (mullerian) tumor
alternative_term: mullerian mixed tumor
has_obo_namespace: disease_ontology
id: DOID:4236
in subset: DO cancer slim
in subset: NCIthesaurus

alveolar soft part sarcoma
type: Class
subclass of: skeletal muscle cancer
textual definition: A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults.
imported from: doid.owl
has_alternative_id: DOID:5315
has_alternative_id: DOID:5318
has cross-reference: GARD:5654
has cross-reference: MESH:D018234
has cross-reference: NCI:C3750
has cross-reference: NCI:C7943
has cross-reference: NCI:C8092
has cross-reference: OMIM:606243
has cross-reference: ORDO:163699
has cross-reference: SNOMEDCT_US_2020_03_01:88195001
has cross-reference: UMLS_CUI:C0206657
has cross-reference: UMLS_CUI:C0279544
has cross-reference: UMLS_CUI:C0279985
alternative_term: Alveolar Soft Part sarcoma
has_obo_namespace: disease_ontology
id: DOID:4239
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pulmonary immaturity
type: Class
subclass of: lung disease
textual definition: A lung disease that is characterized by pulmonary collapse, accompanied by hypoventilation which can affect a lobe, segment, or all of the lung, resulting in a decrease in the ventilation/perfusion ratio.
imported from: doid.owl
has cross-reference: ICD10CM:P28.0
has cross-reference: ICD9CM:770.4
has cross-reference: SNOMEDCT_US_2020_03_01:42908004
has cross-reference: UMLS_CUI:C0270163
alternative_term: primary atelectasis of newborn
alternative_term: primary atelectasis, in perinatal period
has_obo_namespace: disease_ontology
id: DOID:424

kidney sarcoma
type: Class
subclass of: kidney cancer
textual definition: A kidney cancer that is located in the kidney's connective tissue.
imported from: doid.owl
has cross-reference: NCI:C4525
has cross-reference: SNOMEDCT_US_2020_03_01:254918001
has cross-reference: UMLS_CUI:C0346251
alternative_term: renal sarcoma
alternative_term: sarcoma of kidney
has_obo_namespace: disease_ontology
id: DOID:4242
in subset: NCIthesaurus

coronary restenosis
type: Class
subclass of: coronary stenosis
imported from: doid.owl
has cross-reference: MESH:D023903
has cross-reference: UMLS_CUI:C0948480
has_obo_namespace: disease_ontology
id: DOID:4247

coronary stenosis
type: Class
subclass of: coronary artery disease
imported from: doid.owl
has cross-reference: MESH:D023921
has cross-reference: NCI:C80427
has cross-reference: SNOMEDCT_US_2020_03_01:233970002
has cross-reference: UMLS_CUI:C0242231
alternative_term: Coronary artery stenosis
has_obo_namespace: disease_ontology
id: DOID:4248
in subset: NCIthesaurus

Gerstmann-Straussler-Scheinker syndrome
type: Class
subclass of: prion disease
textual definition: A prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain.
imported from: doid.owl
has cross-reference: GARD:7690
has cross-reference: ICD10CM:A81.82
has cross-reference: ICD9CM:046.71
has cross-reference: MESH:D016098
has cross-reference: NCI:C84727
has cross-reference: OMIM:137440
has cross-reference: SNOMEDCT_US_2020_03_01:67155006
has cross-reference: UMLS_CUI:C0017495
alternative_term: Gerstmann-Straussler-Scheinker disease
alternative_term: PRION DEMENTIA
has_obo_namespace: disease_ontology
id: DOID:4249
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

conjunctivochalasis
type: Class
subclass of: conjunctival disease
imported from: doid.owl
has cross-reference: ICD10CM:H11.82
has cross-reference: ICD9CM:372.81
has cross-reference: SNOMEDCT_US_2020_03_01:408663001
has cross-reference: UMLS_CUI:C0878693
has_obo_namespace: disease_ontology
id: DOID:4250

conjunctival disease
type: Class
subclass of: eye disease
textual definition: An eye disease affecting the conjunctiva, which is the mucous membrane surrounding the eye and interior of the eyelids.
imported from: doid.owl
has cross-reference: ICD10CM:H11.9
has cross-reference: ICD9CM:372.9
has cross-reference: MESH:D003229
has cross-reference: NCI:C27605
has cross-reference: SNOMEDCT_US_2020_03_01:194583004
has cross-reference: UMLS_CUI:C0009759
has_obo_namespace: disease_ontology
id: DOID:4251
in subset: NCIthesaurus

Alexander disease
type: Class
subclass of: autosomal dominant disease
subclass of: leukodystrophy
textual definition: A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes.
imported from: doid.owl
has cross-reference: GARD:5774
has cross-reference: MESH:D038261
has cross-reference: NCI:C84545
has cross-reference: OMIM:203450
has cross-reference: SNOMEDCT_US_2020_03_01:81854007
has cross-reference: UMLS_CUI:C0270726
alternative_term: Alexander's disease
has_obo_namespace: disease_ontology
id: DOID:4252
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

melorheostosis
type: Class
subclass of: osteosclerosis
textual definition: An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex.
imported from: doid.owl
has cross-reference: GARD:9474
has cross-reference: MESH:D008557
has cross-reference: NCI:C84887
has cross-reference: OMIM:155950
has cross-reference: SNOMEDCT_US_2020_03_01:240173003
has cross-reference: UMLS_CUI:C0025239
has_obo_namespace: disease_ontology
id: DOID:4253
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

osteosclerosis
type: Class
subclass of: bone remodeling disease
textual definition: A bone remodeling disease that results_in abnormal elevated bone density or mass.
imported from: doid.owl
has cross-reference: ICD10CM:Q78.2
has cross-reference: MESH:D010026
has cross-reference: NCI:C41236
has cross-reference: SNOMEDCT_US_2020_03_01:49347007
has cross-reference: UMLS_CUI:C0029464
has_obo_namespace: disease_ontology
id: DOID:4254
in subset: NCIthesaurus

Caffey disease
type: Class
subclass of: bone inflammation disease
textual definition: A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has symptom soft-tissue swelling, has symptom bone lesions, and has symptom irritability.
imported from: doid.owl
has cross-reference: GARD:1051
has cross-reference: ICD10CM:M89.8
has cross-reference: MESH:D006958
has cross-reference: NCI:C84645
has cross-reference: OMIM:114000
has cross-reference: SNOMEDCT_US_2020_03_01:24752008
has cross-reference: UMLS_CUI:C0020497
alternative_term: cortical congenital hyperostosis
alternative_term: infantile cortical hyperostosis
has_obo_namespace: disease_ontology
id: DOID:4257
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

gait apraxia
type: Class
subclass of: apraxia
imported from: doid.owl
has cross-reference: MESH:D020235
has cross-reference: SNOMEDCT_US_2020_03_01:30767006
has cross-reference: UMLS_CUI:C1510417
has_obo_namespace: disease_ontology
id: DOID:4260

akinetic mutism
type: Class
subclass of: DOID 936
textual definition: A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness.
imported from: doid.owl
has cross-reference: MESH:D000405
has cross-reference: SNOMEDCT_US_2020_03_01:53333005
has cross-reference: UMLS_CUI:C0001889
alternative_term: Coma vigilans
has_obo_namespace: disease_ontology
id: DOID:4267

encephalitozoonosis
type: Class
subclass of: microsporidiosis
textual definition: A microsporidiosis that is a zoonotic infectious disease results_in disseminated fungal infection in dogs, cats, hamsters, guinea pigs, rats, mice and humans, has_material_basis_in Encephalitozoon cuniculi, has_material_basis_in Encephalitozoon intestinalis or has_material_basis_in Encephalitozoon hellem.
imported from: doid.owl
has cross-reference: MESH:D016890
has cross-reference: SNOMEDCT_US_2020_03_01:12825006
has cross-reference: UMLS_CUI:C0085412
alternative_term: Infection by Encephalitozoon
has_obo_namespace: disease_ontology
id: DOID:4270
in subset: zoonotic infectious disease

microsporidiosis
type: Class
subclass of: opportunistic mycosis
textual definition: An opportunistic mycosis that results_in systemic fungal infection in immunocompromised people, has_material_basis_in Microsporidia phylum members.
imported from: doid.owl
has cross-reference: GARD:3655
has cross-reference: ICD10CM:B60.8
has cross-reference: MESH:D016881
has cross-reference: NCI:C84891
has cross-reference: SNOMEDCT_US_2020_03_01:61842000
has cross-reference: UMLS_CUI:C0085407
alternative_term: Infection by Microspora
alternative_term: Infection by Microsporea
alternative_term: Infection by Microsporida
has_obo_namespace: disease_ontology
id: DOID:4271
in subset: NCIthesaurus

nodular basal cell carcinoma
type: Class
subclass of: basal cell carcinoma
textual definition: A basal cell carcinoma characterized by elevated, pearl shaped nodules with telengactisae on the surface and periphery.
imported from: doid.owl
has_alternative_id: DOID:4296
has cross-reference: NCI:C62282
has cross-reference: SNOMEDCT_US_2020_03_01:716274007
has cross-reference: UMLS_CUI:C1304300
alternative_term: Basal cell carcinoma, nodular
alternative_term: Circumscribed solid basal cell carcinoma
alternative_term: skin nodulo-ulcerative basal cell carcinoma
alternative_term: skin solid (nodular) Basal cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:4280
in subset: NCIthesaurus

external ear carcinoma
type: Class
subclass of: carcinoma
subclass of: external ear cancer
textual definition: An external ear cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C6081
has cross-reference: UMLS_CUI:C1333492
alternative_term: carcinoma of the External ear
has_obo_namespace: disease_ontology
has_related_synonym: carcinoma of external ear
id: DOID:4288
in subset: NCIthesaurus

scimitar syndrome
type: Class
subclass of: congenital heart disease
textual definition: A congenital heart disease that is characterized by partial or entire anomalous curved venous drainage of the right lung to the inferior vena cava, association with variable right lung and pulmonary artery hypoplasia, dextraposition of the heart and an anomalous systemic blood supply to the ipsilateral lung.
imported from: doid.owl
has cross-reference: ICD10CM:Q26.8
has cross-reference: MESH:D012587
has cross-reference: NCI:C85056
has cross-reference: OMIM:106700
has cross-reference: ORDO:185
has cross-reference: SNOMEDCT_US_2020_03_01:39905002
has cross-reference: UMLS_CUI:C0036400
alternative_term: Halasz syndrome
alternative_term: congenital venolobar syndrome
alternative_term: hypogenetic lung syndrome
alternative_term: mirror-image lung syndrome
alternative_term: pulmonary venolobar syndrome
alternative_term: total anomalous pulmonary venous return
alternative_term: vena cava bronchovascular syndrome
has_obo_namespace: disease_ontology
id: DOID:4297
in subset: NCIthesaurus

bone giant cell tumor
type: Class
subclass of: benign giant cell tumor
textual definition: A benign giant cell tumor that results_in the presence of multinucleated giant cells.
imported from: doid.owl
has cross-reference: MESH:D018212
has cross-reference: NCI:C121932
has cross-reference: SNOMEDCT_US_2020_03_01:697970009
has cross-reference: UMLS_CUI:C0206638
alternative_term: Giant cell neoplasm of bone
alternative_term: Giant cell tumor of bone
alternative_term: Giant cell tumour of bone
alternative_term: bone giant cell tumour
has_obo_namespace: disease_ontology
has_related_synonym: giant cell myeloma
has_related_synonym: osteoclastoma
id: DOID:4305
in subset: NCIthesaurus

radiculopathy
type: Class
subclass of: peripheral nervous system disease
textual definition: A peripheral nervous system disease that is characterized by the pinching of a nerve root in the spine and has symptoms of pain, weakness, numbness and tingling.
imported from: doid.owl
has cross-reference: ICD10CM:M54.1
has cross-reference: MESH:D011843
has cross-reference: SNOMEDCT_US_2020_03_01:394640000
has cross-reference: UMLS_CUI:C0700594
alternative_term: pinched nerve
has_obo_namespace: disease_ontology
id: DOID:4306

myofascial pain syndrome
type: Class
subclass of: myopathy
imported from: doid.owl
has cross-reference: MESH:D009209
has cross-reference: UMLS_CUI:C0027073
has_obo_namespace: disease_ontology
id: DOID:431

smooth muscle tumor
type: Class
subclass of: muscle benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D018235
has cross-reference: NCI:C3751
has cross-reference: SNOMEDCT_US_2020_03_01:75109009
has cross-reference: UMLS_CUI:C0206658
has_obo_namespace: disease_ontology
id: DOID:4310
in subset: NCIthesaurus

epidermolysis bullosa acquisita
type: Class
subclass of: autoimmune disease of skin and connective tissue
subclass of: epidermolysis bullosa
textual definition: An acquired epidermolysis bullosa that is characterized by formation of recurrent blisters secondary to minor trauma in the skin and mucosa, and has_material_basis_in the development of autoantibodies to type VII collagen.
imported from: doid.owl
has cross-reference: ICD10CM:L12.3
has cross-reference: MESH:D016107
has cross-reference: NCI:C84690
has cross-reference: SNOMEDCT_US_2020_03_01:2772003
has cross-reference: UMLS_CUI:C0079293
alternative_term: acquired epidermolysis bullosa
has_obo_namespace: disease_ontology
id: DOID:4313
in subset: NCIthesaurus

epidermolytic acanthoma
type: Class
subclass of: acanthoma
imported from: doid.owl
has cross-reference: NCI:C27516
has cross-reference: SNOMEDCT_US_2020_03_01:733892008
has cross-reference: UMLS_CUI:C1333414
has_obo_namespace: disease_ontology
id: DOID:4323
in subset: NCIthesaurus

Ebola hemorrhagic fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted by contaminated fomites, or transmitted by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.
imported from: doid.owl
has cross-reference: GARD:2035
has cross-reference: ICD10CM:A98.4
has cross-reference: MESH:D019142
has cross-reference: NCI:C36171
has cross-reference: SNOMEDCT_US_2020_03_01:123323003
has cross-reference: UMLS_CUI:C0282687
alternative_term: Ebola virus disease
has_obo_namespace: disease_ontology
id: DOID:4325
in subset: NCIthesaurus
in subset: zoonotic infectious disease

Marburg hemorrhagic fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.
imported from: doid.owl
has cross-reference: GARD:9444
has cross-reference: ICD10CM:A98.3
has cross-reference: MESH:D008379
has cross-reference: NCI:C84883
has cross-reference: SNOMEDCT_US_2020_03_01:123322008
has cross-reference: UMLS_CUI:C0024788
alternative_term: Marburg disease
alternative_term: Marburg virus disease
has_obo_namespace: disease_ontology
id: DOID:4327
in subset: NCIthesaurus

non-Langerhans-cell histiocytosis
type: Class
subclass of: histiocytosis
imported from: doid.owl
has cross-reference: GARD:8231
has cross-reference: MESH:D015616
has cross-reference: SNOMEDCT_US_2020_03_01:127069007
has cross-reference: UMLS_CUI:C0019624
has_obo_namespace: disease_ontology
id: DOID:4330

parovarian cyst
type: Class
subclass of: female reproductive system disease
textual definition: A female reproductive system disease that is characterized by epithelium-lined fluid-filled cysts in the adnexa adjacent to the fallopian tube and ovary.
imported from: doid.owl
has cross-reference: ICD10CM:Q50.5
has cross-reference: MESH:D010310
has cross-reference: SNOMEDCT_US_2020_03_01:204831002
has cross-reference: UMLS_CUI:C0030584
alternative_term: Cyst, fimbrial
alternative_term: Embryonic fimbrial cyst
has_obo_namespace: disease_ontology
id: DOID:4333

tinea favosa
type: Class
subclass of: skin disease
subclass of: nail disease
subclass of: tinea capitis
textual definition: A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.
imported from: doid.owl
has_alternative_id: DOID:0050109
has cross-reference: ICD10CM:B35
has cross-reference: MESH:D014007
has cross-reference: NCI:C35072
has cross-reference: SNOMEDCT_US_2020_03_01:85375000
has cross-reference: UMLS_CUI:C0040254
alternative_term: favus
has_obo_namespace: disease_ontology
id: DOID:4336
in subset: NCIthesaurus

tinea capitis
type: Class
subclass of: hair disease
subclass of: DOID 8913
textual definition: A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.
imported from: doid.owl
has_alternative_id: DOID:0050114
has_alternative_id: DOID:12319
has cross-reference: ICD9CM:110.0
has cross-reference: NCI:C34536
has cross-reference: SNOMEDCT_US_2020_03_01:186985002
has cross-reference: UMLS_CUI:C0011640
alternative_term: Scalp ringworm
alternative_term: Trichophyton rubrum tinea capitis
alternative_term: dermatophytosis of scalp or beard
alternative_term: tinea capitis due to Trichophyton rubrum
has_obo_namespace: disease_ontology
has_related_synonym: Dermatophytosis of scalp
id: DOID:4337
in subset: NCIthesaurus

variegate porphyria
type: Class
subclass of: acute porphyria
imported from: doid.owl
has cross-reference: GARD:7848
has cross-reference: MESH:D046350
has cross-reference: NCI:C85219
has cross-reference: OMIM:176200
has cross-reference: SNOMEDCT_US_2020_03_01:58275005
has cross-reference: UMLS_CUI:C0162532
alternative_term: Protocoproporphyria
alternative_term: Protoporphyrinogen oxidase deficiency
alternative_term: Variegate porphyria
has_obo_namespace: disease_ontology
id: DOID:4346
in subset: NCIthesaurus

lymphocele
type: Class
subclass of: lymphatic system disease
imported from: doid.owl
has cross-reference: MESH:D008210
has cross-reference: NCI:C78442
has cross-reference: SNOMEDCT_US_2020_03_01:234109007
has cross-reference: UMLS_CUI:C0024248
alternative_term: Lymph cyst
has_obo_namespace: disease_ontology
id: DOID:4347
in subset: NCIthesaurus

cervical cancer
type: Class
subclass of: cervix disease
subclass of: uterine cancer
textual definition: A female reproductive organ cancer that is located_in the cervix.
imported from: doid.owl
has_alternative_id: DOID:4361
has cross-reference: ICD10CM:C53
has cross-reference: ICD9CM:180
has cross-reference: MESH:D002583
has cross-reference: NCI:C2940
has cross-reference: NCI:C9311
has cross-reference: OMIM:603956
has cross-reference: SNOMEDCT_US_2020_03_01:123841004
has cross-reference: SNOMEDCT_US_2020_03_01:254885005
has cross-reference: UMLS_CUI:C0007847
has cross-reference: UMLS_CUI:C0007873
alternative_term: cervical neoplasm
alternative_term: cervix cancer
alternative_term: cervix uteri cancer
alternative_term: neoplasm of uterine cervix
alternative_term: tumor of the Cervix Uteri
alternative_term: uterine cervical neoplasm
has_obo_namespace: disease_ontology
id: DOID:4362
in subset: DO cancer slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

apparent mineralocorticoid excess syndrome
type: Class
subclass of: steroid inherited metabolic disorder
subclass of: genetic disease
textual definition: A steroid inherited metabolic disorder characterized by decreased conversion of biologically active cortisol to inactive cortisone resulting in low aldosterone levels, metabolic alkalosis, hypernatremia, hypokalemia and early-onset severe hypertension that has_material_basis_in homozygous or compound heterozygous mutation in the HSD11B2 gene on chromosome 16.
imported from: doid.owl
has_alternative_id: DOID:0090121
has cross-reference: GARD:433
has cross-reference: MESH:D043204
has cross-reference: NCI:C123231
has cross-reference: OMIM:218030
has cross-reference: ORDO:320
has cross-reference: SNOMEDCT_US_2020_03_01:237770005
has cross-reference: UMLS_CUI:C0342488
alternative_term: 11-beta-hydroxysteroid dehydrogenase deficiency type 2
alternative_term: Ulick syndrome
alternative_term: cortisol 11-beta-ketoreductase deficiency
alternative_term: syndrome of apparent mineralocorticoid excess
has_obo_namespace: disease_ontology
id: DOID:4367
in subset: NCIthesaurus

myasthenia gravis
type: Class
subclass of: autoimmune disease of the nervous system
textual definition: An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath.
imported from: doid.owl
has_alternative_id: DOID:443
has_alternative_id: DOID:444
has cross-reference: GARD:7122
has cross-reference: ICD10CM:G70.0
has cross-reference: ICD10CM:G70.00
has cross-reference: ICD9CM:358.0
has cross-reference: ICD9CM:358.00
has cross-reference: MESH:D009157
has cross-reference: NCI:C60989
has cross-reference: OMIM:254200
has cross-reference: SNOMEDCT_US_2020_03_01:155092009
has cross-reference: UMLS_CUI:C0026896
has cross-reference: UMLS_CUI:C1260409
has_obo_namespace: disease_ontology
id: DOID:437
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Schnitzler syndrome
type: Class
subclass of: hypersensitivity reaction type IV disease
textual definition: A hypersensitivity reaction type IV disease that is characterized by chronic urticarial rash and monoclonal IgM gammopathy, has_symptom rash, intermittent fever, arthralgia, and lymphadenopathy.
imported from: doid.owl
has cross-reference: GARD:12390
has cross-reference: MESH:D019873
has cross-reference: SNOMEDCT_US_2020_03_01:402415001
has cross-reference: UMLS_CUI:C0524988
has_obo_namespace: disease_ontology
id: DOID:4371

intracranial embolism
type: Class
subclass of: cerebrovascular disease
imported from: doid.owl
has_alternative_id: DOID:1957
has_alternative_id: DOID:1958
has cross-reference: ICD10CM:I66
has cross-reference: ICD9CM:434.1
has cross-reference: MESH:D020766
has cross-reference: SNOMEDCT_US_2020_03_01:75543006
has cross-reference: UMLS_CUI:C0007780
has cross-reference: UMLS_CUI:C0752140
alternative_term: Cerebral embolism with cerebral infarction
alternative_term: cerebral embolism
has_obo_namespace: disease_ontology
id: DOID:4372

egg allergy
type: Class
subclass of: food allergy
textual definition: A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms.
imported from: doid.owl
has cross-reference: MESH:D021181
has cross-reference: SNOMEDCT_US_2020_03_01:91930004
has cross-reference: UMLS_CUI:C0559469
alternative_term: Allergy to eggs
has_obo_namespace: disease_ontology
id: DOID:4377
in subset: DO IEDB slim

peanut allergy
type: Class
subclass of: legume allergy
textual definition: A legume allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms.
imported from: doid.owl
has cross-reference: MESH:D021183
has cross-reference: SNOMEDCT_US_2020_03_01:91935009
has cross-reference: UMLS_CUI:C0559470
alternative_term: allergy to peanuts
alternative_term: peanut allergic reaction
has_obo_namespace: disease_ontology
id: DOID:4378
in subset: DO IEDB slim

autoimmune disease of the nervous system
type: Class
subclass of: autoimmune disease
subclass of: DOID 863
textual definition: An autoimmune disease affecting the nervous system.
imported from: doid.owl
has cross-reference: MESH:D020274
has cross-reference: NCI:C99383
has cross-reference: UMLS_CUI:C0751871
has_obo_namespace: disease_ontology
has_related_synonym: autoimmune nervous system disorder
id: DOID:438
in subset: NCIthesaurus

myofibroma
type: Class
subclass of: connective tissue benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D047708
has cross-reference: SNOMEDCT_US_2020_03_01:128917003
has cross-reference: UMLS_CUI:C1266121
alternative_term: Lipoleiomyoma
alternative_term: Myofibroma
has_obo_namespace: disease_ontology
id: DOID:4386

neuromuscular junction disease
type: Class
subclass of: neuromuscular disease
textual definition: A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction.
imported from: doid.owl
has cross-reference: MESH:D020511
has cross-reference: SNOMEDCT_US_2020_03_01:128213006
has cross-reference: UMLS_CUI:C0751950
has_obo_namespace: disease_ontology
id: DOID:439

pustulosis of palm and sole
type: Class
subclass of: dermatitis
imported from: doid.owl
has cross-reference: ICD10CM:L40.3
has cross-reference: MESH:D011565
has cross-reference: NCI:C34888
has cross-reference: SNOMEDCT_US_2020_03_01:238610005
has cross-reference: UMLS_CUI:C0030246
alternative_term: Acropustulosis
alternative_term: Palmoplantar Pustulosis
alternative_term: Pustular psoriasis of the palms and/or soles
has_obo_namespace: disease_ontology
id: DOID:4398
in subset: NCIthesaurus

acneiform dermatitis
type: Class
subclass of: dermatitis
imported from: doid.owl
has cross-reference: NCI:C35277
has cross-reference: UMLS_CUI:C0234894
has_obo_namespace: disease_ontology
id: DOID:4399
in subset: NCIthesaurus

neuromuscular disease
type: Class
subclass of: musculoskeletal system disease
subclass of: DOID 870
textual definition: A neuropathy that affect the nerves that control the voluntary muscles.
imported from: doid.owl
has cross-reference: ICD10CM:G70.9
has cross-reference: ICD9CM:358
has cross-reference: MESH:D009468
has cross-reference: SNOMEDCT_US_2020_03_01:1664005
has cross-reference: UMLS_CUI:C0027868
has_obo_namespace: disease_ontology
id: DOID:440

folliculitis
type: Class
subclass of: dermatitis
subclass of: hair disease
imported from: doid.owl
has cross-reference: MESH:D005499
has cross-reference: NCI:C94408
has cross-reference: SNOMEDCT_US_2020_03_01:156411003
has cross-reference: UMLS_CUI:C0016436
has_obo_namespace: disease_ontology
id: DOID:4409
in subset: NCIthesaurus

hepatitis E
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.
imported from: doid.owl
has_alternative_id: DOID:12431
has cross-reference: GARD:9541
has cross-reference: MESH:D016751
has cross-reference: SNOMEDCT_US_2020_03_01:7111000119109
has cross-reference: UMLS_CUI:C0085293
has_obo_namespace: disease_ontology
id: DOID:4411
in subset: zoonotic infectious disease

fibrous histiocytoma
type: Class
subclass of: histiocytoma
imported from: doid.owl
has cross-reference: MESH:D018219
has cross-reference: NCI:C3739
has cross-reference: SNOMEDCT_US_2020_03_01:25889007
has cross-reference: UMLS_CUI:C0206644
alternative_term: Fibroxanthoma
alternative_term: benign fibrous histiocytoma
alternative_term: fibrous Histiocytoma
has_obo_namespace: disease_ontology
id: DOID:4415
in subset: NCIthesaurus

cutaneous fibrous histiocytoma
type: Class
subclass of: skin benign neoplasm
subclass of: fibrous histiocytoma
imported from: doid.owl
has_alternative_id: DOID:4417
has cross-reference: GARD:9807
has cross-reference: MESH:D018219
has cross-reference: NCI:C6801
has cross-reference: NCI:C8402
has cross-reference: SNOMEDCT_US_2020_03_01:254749001
has cross-reference: SNOMEDCT_US_2020_03_01:403999006
has cross-reference: UMLS_CUI:C0002991
has cross-reference: UMLS_CUI:C0346049
alternative_term: Dermatofibroma
alternative_term: Fibrohistiocytic tumor
alternative_term: Pleomorphic fibroma
alternative_term: Sclerosing angioma
alternative_term: Sclerosing angioma of skin
alternative_term: benign Cutaneous fibrous Histiocytoma
alternative_term: dermatofibroma
alternative_term: fibrohistiocytic tumor
alternative_term: fibrous histiocytoma of skin
alternative_term: fibrous xanthoma of skin
has_obo_namespace: disease_ontology
id: DOID:4418
in subset: NCIthesaurus

sea-blue histiocytosis
type: Class
subclass of: sphingolipidosis
textual definition: A sphingolipidosis characterized by dysfunctional metabolism of sphingolipids.
imported from: doid.owl
has cross-reference: MESH:D012618
has cross-reference: NCI:C85062
has cross-reference: OMIM:269600
has cross-reference: SNOMEDCT_US_2020_03_01:37821003
has cross-reference: UMLS_CUI:C0036489
alternative_term: Sea-blue histiocyte syndrome
has_obo_namespace: disease_ontology
id: DOID:4423
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

juvenile xanthogranuloma
type: Class
subclass of: non-Langerhans-cell histiocytosis
imported from: doid.owl
has cross-reference: MESH:D014972
has cross-reference: NCI:C3451
has cross-reference: SNOMEDCT_US_2020_03_01:71709009
has cross-reference: UMLS_CUI:C0043324
alternative_term: Multiple eruptive juvenile xanthogranuloma
alternative_term: Naevoxanthoendothelioma
alternative_term: Xanthoma neviforme
has_obo_namespace: disease_ontology
id: DOID:4424
in subset: NCIthesaurus

dyslexia
type: Class
subclass of: reading disorder
textual definition: A reading disorder resulting from a developmental reading disability involving the inability to process graphic symbols resulting in impairment of reading ability.
imported from: doid.owl
has cross-reference: ICD10CM:F81.0
has cross-reference: MESH:D004410
has cross-reference: NCI:C96410
has cross-reference: OMIM:300509
has cross-reference: OMIM:600202
has cross-reference: OMIM:604254
has cross-reference: OMIM:606616
has cross-reference: OMIM:606896
has cross-reference: OMIM:608995
has cross-reference: SNOMEDCT_US_2020_03_01:154954003
has cross-reference: UMLS_CUI:C0476254
has_obo_namespace: disease_ontology
id: DOID:4428
in subset: NCIthesaurus
comment: Xref MGI.

somatostatinoma
type: Class
subclass of: neuroendocrine tumor
imported from: doid.owl
has cross-reference: GARD:4900
has cross-reference: MESH:D013005
has cross-reference: NCI:C3379
has cross-reference: SNOMEDCT_US_2020_03_01:128642005
has cross-reference: UMLS_CUI:C0037661
alternative_term: Somatostatin cell neoplasm
alternative_term: Somatostatin cell tumour
has_obo_namespace: disease_ontology
id: DOID:4430
in subset: NCIthesaurus

skull base meningioma
type: Class
subclass of: skull base cancer
imported from: doid.owl
has cross-reference: NCI:C5272
has cross-reference: UMLS_CUI:C1335976
alternative_term: meningioma of the Skull Base
has_obo_namespace: disease_ontology
id: DOID:4437
in subset: NCIthesaurus

central nervous system germ cell tumor
type: Class
subclass of: germ cell cancer
subclass of: central nervous system cancer
textual definition: A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has_material_basis_in abnormally proliferating cells derives_from germ cells.
imported from: doid.owl
has cross-reference: NCI:C5461
has cross-reference: UMLS_CUI:C1332880
alternative_term: central nervous system germ cell tumour
alternative_term: germ cell tumor of the CNS
alternative_term: germ cell tumour of the CNS
has_obo_namespace: disease_ontology
id: DOID:4439
in subset: NCIthesaurus

seminoma
type: Class
subclass of: germ cell cancer
textual definition: A germinoma that has_material_basis_in cells that make sperm and eggs.
imported from: doid.owl
has cross-reference: MESH:D018239
has cross-reference: NCI:C9309
has cross-reference: SNOMEDCT_US_2020_03_01:443675005
has cross-reference: UMLS_CUI:C0036631
alternative_term: Seminoma, Pure
has_obo_namespace: disease_ontology
id: DOID:4440
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

dysgerminoma
type: Class
subclass of: ovarian cancer
subclass of: germ cell cancer
textual definition: A germ cell cancer that derives_from cells that give rise to egg cells.
imported from: doid.owl
has cross-reference: MESH:D004407
has cross-reference: NCI:C2996
has cross-reference: SNOMEDCT_US_2020_03_01:60718004
has cross-reference: UMLS_CUI:C0013377
has_obo_namespace: disease_ontology
id: DOID:4441
in subset: NCIthesaurus

cystoid macular edema
type: Class
subclass of: macular retinal edema
imported from: doid.owl
has cross-reference: MESH:D008269
has cross-reference: NCI:C34794
has cross-reference: OMIM:153880
has cross-reference: SNOMEDCT_US_2020_03_01:193387007
has cross-reference: UMLS_CUI:C0024440
has_obo_namespace: disease_ontology
id: DOID:4447
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

macular degeneration
type: Class
subclass of: retinal degeneration
textual definition: A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.
imported from: doid.owl
has cross-reference: MESH:D008268
has cross-reference: NCI:C123330
has cross-reference: ORDO:279
has cross-reference: SNOMEDCT_US_2020_03_01:302891003
has cross-reference: UMLS_CUI:C0024437
alternative_term: Macular degeneration of retina
has_obo_namespace: disease_ontology
id: DOID:4448
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

macular retinal edema
type: Class
subclass of: retinal edema
imported from: doid.owl
has cross-reference: MESH:D008269
has cross-reference: NCI:C35468
has cross-reference: SNOMEDCT_US_2020_03_01:37231002
has cross-reference: UMLS_CUI:C0271051
alternative_term: macular edema
alternative_term: macular oedema
alternative_term: macular retinal oedema
has_obo_namespace: disease_ontology
id: DOID:4449
in subset: NCIthesaurus

Bartter disease
type: Class
subclass of: monogenic disease
subclass of: renal tubular transport disease
imported from: doid.owl
has cross-reference: GARD:5893
has cross-reference: ICD10CM:E26.81
has cross-reference: ICD9CM:255.13
has cross-reference: MESH:D001477
has cross-reference: NCI:C34412
has cross-reference: OMIM:PS601678
has cross-reference: SNOMEDCT_US_2020_03_01:707742001
has cross-reference: UMLS_CUI:C0004775
alternative_term: Aldosteronism with hyperplasia of the adrenal cortex
alternative_term: Bartter's syndrome
has_obo_namespace: disease_ontology
id: DOID:445
in subset: NCIthesaurus

renal cell carcinoma
type: Class
subclass of: renal carcinoma
textual definition: A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.
imported from: doid.owl
has cross-reference: EFO:0000681
has cross-reference: GARD:13215
has cross-reference: MESH:D002292
has cross-reference: NCI:C9385
has cross-reference: OMIM:300854
has cross-reference: ORDO:217071
has cross-reference: SNOMEDCT_US_2020_03_01:254915003
has cross-reference: UMLS_CUI:C0007134
alternative_term: RCC
alternative_term: adenocarcinoma of kidney
alternative_term: hypernephroma
has_obo_namespace: disease_ontology
id: DOID:4450
in subset: DO cancer slim
in subset: NCIthesaurus
comment: Xref MGI.

renal carcinoma
type: Class
subclass of: kidney cancer
subclass of: carcinoma
textual definition: A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).
imported from: doid.owl
has cross-reference: NCI:C9384
has cross-reference: SNOMEDCT_US_2020_03_01:254915003
has cross-reference: UMLS_CUI:C1378703
alternative_term: carcinoma of kidney
alternative_term: kidney carcinoma
has_obo_namespace: disease_ontology
id: DOID:4451
in subset: DO cancer slim
in subset: NCIthesaurus

hereditary renal cell carcinoma
type: Class
subclass of: renal cell carcinoma
imported from: doid.owl
has cross-reference: GARD:9571
has_obo_namespace: disease_ontology
id: DOID:4455

primary hyperaldosteronism
type: Class
subclass of: adrenal gland hyperfunction
textual definition: An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.
imported from: doid.owl
has_alternative_id: DOID:12252
has cross-reference: ICD10CM:E24
has cross-reference: ICD10CM:E26
has cross-reference: ICD9CM:255.0
has cross-reference: ICD9CM:255.1
has cross-reference: MESH:D003480
has cross-reference: MESH:D006929
has cross-reference: NCI:C113213
has cross-reference: NCI:C2969
has cross-reference: OMIM:605635
has cross-reference: OMIM:613677
has cross-reference: ORDO:235936
has cross-reference: SNOMEDCT_US_2020_03_01:154705004
has cross-reference: SNOMEDCT_US_2020_03_01:88213004
has cross-reference: UMLS_CUI:C0010481
has cross-reference: UMLS_CUI:C0020428
alternative_term: Cushing syndrome
alternative_term: Cushing's syndrome
alternative_term: hyperaldosteronism
has_obo_namespace: disease_ontology
id: DOID:446
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

multilocular clear cell renal cell carcinoma
type: Class
subclass of: renal cell carcinoma
imported from: doid.owl
has cross-reference: NCI:C4524
has cross-reference: SNOMEDCT_US_2020_03_01:254916002
has cross-reference: UMLS_CUI:C0346249
alternative_term: cystadenocarcinoma of kidney
alternative_term: renal cystadenocarcinoma
has_obo_namespace: disease_ontology
id: DOID:4463
in subset: NCIthesaurus

collecting duct carcinoma
type: Class
subclass of: renal cell carcinoma
textual definition: A renal cell carcinoma that begins in distal collecting ducts of the kidney with a tubulopapillary morphology and intracytoplasmic mucicarminophilic material.
imported from: doid.owl
has cross-reference: GARD:9573
has cross-reference: MESH:D002292
has cross-reference: NCI:C6194
has cross-reference: SNOMEDCT_US_2020_03_01:733470002
has cross-reference: UMLS_CUI:C1266044
alternative_term: carcinoma of renal Collecting duct
alternative_term: renal Medullary carcinoma
alternative_term: renal carcinoma, collecting duct type
has_obo_namespace: disease_ontology
id: DOID:4464
in subset: NCIthesaurus

papillary renal cell carcinoma
type: Class
subclass of: renal cell carcinoma
textual definition: A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors.
imported from: doid.owl
has_alternative_id: DOID:8063
has cross-reference: GARD:9572
has cross-reference: MESH:C538614
has cross-reference: MESH:D002292
has cross-reference: NCI:C27890
has cross-reference: NCI:C6975
has cross-reference: OMIM:605074
has cross-reference: SNOMEDCT_US_2020_03_01:4797003
has cross-reference: UMLS_CUI:C1306837
has cross-reference: UMLS_CUI:C1336078
alternative_term: Chromophil carcinoma of kidney
alternative_term: Papillary renal cell carcinoma
alternative_term: papillary kidney carcinoma
alternative_term: sporadic papillary renal cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:4465
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

clear cell renal cell carcinoma
type: Class
subclass of: renal cell carcinoma
textual definition: A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.
imported from: doid.owl
has cross-reference: GARD:9574
has cross-reference: MESH:D002292
has cross-reference: NCI:C4033
has cross-reference: SNOMEDCT_US_2020_03_01:254915003
has cross-reference: UMLS_CUI:C0279702
alternative_term: Clear cell carcinoma of kidney
alternative_term: clear cell kidney carcinoma
alternative_term: conventional (Clear cell) renal cell carcinoma
alternative_term: conventional renal cell carcinoma
alternative_term: renal clear cell carcinoma
has_obo_namespace: disease_ontology
has_related_synonym: Clear-cell metastatic renal cell carcinoma
id: DOID:4467
in subset: DO cancer slim
in subset: NCIthesaurus
comment: MESH:C538445 added from NeuroDevNet [WAK].

clear cell adenocarcinoma
type: Class
subclass of: adenocarcinoma
textual definition: An adenocarcinoma that derives_from epithelial cells which have clear cytoplasm.
imported from: doid.owl
has_alternative_id: DOID:2617
has_alternative_id: DOID:4940
has cross-reference: MESH:D008649
has cross-reference: MESH:D018262
has cross-reference: NCI:C36815
has cross-reference: NCI:C4072
has cross-reference: NCI:C4156
has cross-reference: SNOMEDCT_US_2020_03_01:2221008
has cross-reference: SNOMEDCT_US_2020_03_01:30546008
has cross-reference: SNOMEDCT_US_2020_03_01:80727009
has cross-reference: UMLS_CUI:C0025490
has cross-reference: UMLS_CUI:C0206681
has cross-reference: UMLS_CUI:C0334322
alternative_term: Clear cell adenocarcinoma
alternative_term: Mesonephroid Clear cell carcinoma
alternative_term: Mesonephroma
alternative_term: Mesonephroma, malignant
alternative_term: Water-Clear cell adenocarcinoma
alternative_term: Water-clear cell adenocarcinoma
alternative_term: Water-clear cell carcinoma
alternative_term: Wolffian duct neoplasm
alternative_term: malignant Mesonephroma
alternative_term: mesonephroma
has_obo_namespace: disease_ontology
id: DOID:4468
in subset: NCIthesaurus

renal tubular transport disease
type: Class
subclass of: kidney disease
imported from: doid.owl
has cross-reference: MESH:D015499
has cross-reference: UMLS_CUI:C0035091
alternative_term: inborn renal tubular transport disorder
has_obo_namespace: disease_ontology
id: DOID:447

chromophobe renal cell carcinoma
type: Class
subclass of: renal cell carcinoma
textual definition: A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells.
imported from: doid.owl
has cross-reference: GARD:6064
has cross-reference: MESH:D002292
has cross-reference: NCI:C4146
has cross-reference: SNOMEDCT_US_2020_03_01:128667008
has cross-reference: UMLS_CUI:C1266042
alternative_term: Chromophobe carcinoma of kidney
alternative_term: chromophobe adenocarcinoma
alternative_term: kidney chromophobe
alternative_term: renal cell carcinoma, chromophobe cell
has_obo_namespace: disease_ontology
id: DOID:4471
in subset: DO cancer slim
in subset: NCIthesaurus

pseudohypoaldosteronism
type: Class
subclass of: renal tubular transport disease
imported from: doid.owl
has cross-reference: MESH:D011546
has cross-reference: NCI:C85034
has cross-reference: SNOMEDCT_US_2020_03_01:77098009
has cross-reference: UMLS_CUI:C0033805
has_obo_namespace: disease_ontology
id: DOID:4479
in subset: DO FlyBase slim
in subset: NCIthesaurus

achondroplasia
type: Class
subclass of: osteochondrodysplasia
textual definition: An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.
imported from: doid.owl
has cross-reference: GARD:8173
has cross-reference: ICD10CM:Q77.4
has cross-reference: MESH:D000130
has cross-reference: NCI:C34345
has cross-reference: OMIM:100800
has cross-reference: SNOMEDCT_US_2020_03_01:268273004
has cross-reference: UMLS_CUI:C0001080
alternative_term: Achondroplastic physique
alternative_term: Chondrodystrophia
alternative_term: osteosclerosis congenita
has_obo_namespace: disease_ontology
id: DOID:4480
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

allergic rhinitis
type: Class
subclass of: respiratory allergy
subclass of: rhinitis
textual definition: A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.
imported from: doid.owl
has_alternative_id: DOID:12089
has_alternative_id: DOID:14030
has_alternative_id: DOID:8241
has_alternative_id: DOID:8242
has cross-reference: EFO:0003956
has cross-reference: NCI:C34987
has cross-reference: OMIM:607154
has cross-reference: SNOMEDCT_US_2020_03_01:38103000
has cross-reference: UMLS_CUI:C0002103
alternative_term: Non-seasonal allergic rhinitis
alternative_term: Perenial allergic rhinitis
alternative_term: atopic rhinitis
alternative_term: hay fever
alternative_term: pollenosis
alternative_term: seasonal allergic rhinitis
has_obo_namespace: disease_ontology
id: DOID:4481
in subset: NCIthesaurus

rhinitis
type: Class
subclass of: nasal cavity disease
textual definition: A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.
imported from: doid.owl
has cross-reference: MESH:D012220
has cross-reference: NCI:C34986
has cross-reference: SNOMEDCT_US_2020_03_01:70076002
has cross-reference: UMLS_CUI:C0035455
has_obo_namespace: disease_ontology
has_related_synonym: runny nose
id: DOID:4483
in subset: NCIthesaurus

avian influenza
type: Class
subclass of: influenza
textual definition: An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.
imported from: doid.owl
has cross-reference: ICD10CM:J09.X
has cross-reference: MESH:D005585
has cross-reference: SNOMEDCT_US_2020_03_01:55604004
has cross-reference: UMLS_CUI:C0016627
alternative_term: avian flu
alternative_term: bird flu
has_obo_namespace: disease_ontology
id: DOID:4492
in subset: zoonotic infectious disease

myotonic disease
type: Class
subclass of: DOID 9884
textual definition: A muscular dystrophy that is characterized by progressive muscle wasting and weakness.
imported from: doid.owl
has cross-reference: ICD10CM:G71.1
has cross-reference: ICD9CM:359.2
has cross-reference: MESH:D020967
has cross-reference: NCI:C84913
has cross-reference: SNOMEDCT_US_2020_03_01:155096007
has cross-reference: UMLS_CUI:C0553604
has_obo_namespace: disease_ontology
id: DOID:450
in subset: DO FlyBase slim
in subset: NCIthesaurus

hypokalemia
type: Class
subclass of: mineral metabolism disease
imported from: doid.owl
has cross-reference: NCI:C34939
has cross-reference: UMLS_CUI:C1514284
alternative_term: hypopotassemia
alternative_term: potassium deficiency disorder
has_obo_namespace: disease_ontology
id: DOID:4500
in subset: NCIthesaurus

orofaciodigital syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by malformations of the face, oral cavity, and digits.
imported from: doid.owl
has cross-reference: ICD10CM:Q87.0
has cross-reference: MESH:D009958
has cross-reference: SNOMEDCT_US_2020_03_01:52868006
has cross-reference: UMLS_CUI:C0029294
alternative_term: oral-facial-digital syndrome
has_obo_namespace: disease_ontology
id: DOID:4501
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

pleomorphic adenoma
type: Class
subclass of: gastrointestinal system benign neoplasm
textual definition: A gastrointestinal system benign neoplasm that is a located_in the salivary glands.
imported from: doid.owl
has cross-reference: MESH:D008949
has cross-reference: NCI:C35691
has cross-reference: OMIM:181030
has cross-reference: SNOMEDCT_US_2020_03_01:8360001
has cross-reference: UMLS_CUI:C0026277
alternative_term: Pleomorphic adenoma
alternative_term: mixed tumor of the Salivary gland
has_obo_namespace: disease_ontology
id: DOID:452
in subset: NCIthesaurus

mucoepidermoid carcinoma
type: Class
subclass of: salivary gland carcinoma
textual definition: A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.
imported from: doid.owl
has cross-reference: GARD:10671
has cross-reference: MESH:D018277
has cross-reference: NCI:C3772
has cross-reference: SNOMEDCT_US_2020_03_01:4079000
has cross-reference: UMLS_CUI:C0206694
alternative_term: MEC
alternative_term: Mucoepidermoid carcinoma
has_obo_namespace: disease_ontology
id: DOID:4531
in subset: NCIthesaurus

Hallermann-Streiff syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that affects growth, cranial development, hair growth and dental development.
imported from: doid.owl
has cross-reference: GARD:288
has cross-reference: MESH:D006210
has cross-reference: NCI:C84746
has cross-reference: OMIM:234100
has cross-reference: ORDO:2108
has cross-reference: SNOMEDCT_US_2020_03_01:7903009
has cross-reference: UMLS_CUI:C0018522
alternative_term: Francois dyscephalic syndrome
alternative_term: Hallerman - Streiff syndrome
alternative_term: Hallermann's syndrome
has_obo_namespace: disease_ontology
id: DOID:4534
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hypotrichosis
type: Class
subclass of: hair disease
textual definition: A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.
imported from: doid.owl
has cross-reference: MESH:D007039
has cross-reference: OMIM:PS605389
has cross-reference: ORDO:55654
has cross-reference: SNOMEDCT_US_2020_03_01:53602002
has cross-reference: UMLS_CUI:C0020678
has_obo_namespace: disease_ontology
id: DOID:4535
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

dysgraphia
type: Class
subclass of: writing disorder
textual definition: A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper.
imported from: doid.owl
has cross-reference: ICD10CM:R48.8
has cross-reference: MESH:D000381
has cross-reference: SNOMEDCT_US_2020_03_01:27206009
has cross-reference: UMLS_CUI:C0001825
has_obo_namespace: disease_ontology
id: DOID:4540

retrograde amnesia
type: Class
subclass of: amnestic disorder
textual definition: An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection.
imported from: doid.owl
has cross-reference: ICD10CM:R41.2
has cross-reference: MESH:D000648
has cross-reference: NCI:C34372
has cross-reference: SNOMEDCT_US_2020_03_01:51921000
has cross-reference: UMLS_CUI:C0002624
has_obo_namespace: disease_ontology
id: DOID:4543
in subset: NCIthesaurus

mesenchymal chondrosarcoma
type: Class
subclass of: chondrosarcoma
imported from: doid.owl
has cross-reference: MESH:D018211
has cross-reference: NCI:C3737
has cross-reference: SNOMEDCT_US_2020_03_01:56565002
has cross-reference: UMLS_CUI:C0206637
has_obo_namespace: disease_ontology
id: DOID:4545
in subset: NCIthesaurus

extraskeletal mesenchymal chondrosarcoma
type: Class
subclass of: extraosseous chondrosarcoma
imported from: doid.owl
has cross-reference: NCI:C27481
has cross-reference: SNOMEDCT_US_2020_03_01:404080006
has cross-reference: UMLS_CUI:C1275279
alternative_term: mesenchymal extraosseous chondrosarcoma
has_obo_namespace: disease_ontology
id: DOID:4548
in subset: NCIthesaurus

extraosseous chondrosarcoma
type: Class
subclass of: chondrosarcoma
textual definition: A chondrosarcoma that is located_in exclusively soft tissue.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:4549

anus benign neoplasm
type: Class
subclass of: anus disease
subclass of: intestinal benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D001005
has cross-reference: NCI:C2877
has cross-reference: SNOMEDCT_US_2020_03_01:126849006
has cross-reference: UMLS_CUI:C0003463
alternative_term: anal neoplasm
alternative_term: anal tumors
alternative_term: neoplasm of anus
has_obo_namespace: disease_ontology
id: DOID:4551
in subset: NCIthesaurus

lung large cell carcinoma
type: Class
subclass of: lung non-small cell carcinoma
imported from: doid.owl
has cross-reference: NCI:C4450
has cross-reference: SNOMEDCT_US_2020_03_01:254629004
has cross-reference: UMLS_CUI:C0345958
alternative_term: large cell carcinoma of lung
alternative_term: large cell lung carcinoma
has_obo_namespace: disease_ontology
id: DOID:4556
in subset: DO cancer slim
in subset: NCIthesaurus

ascariasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation.
imported from: doid.owl
has cross-reference: ICD10CM:B77
has cross-reference: ICD9CM:127.0
has cross-reference: MESH:D001196
has cross-reference: NCI:C128392
has cross-reference: SNOMEDCT_US_2020_03_01:2435008
has cross-reference: UMLS_CUI:C0003950
alternative_term: Ascariasis - roundworm
has_obo_namespace: disease_ontology
has_related_synonym: Ascaris lumbricoides infection
id: DOID:456
in subset: NCIthesaurus

benign meningioma
type: Class
subclass of: central nervous system benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D008579
has cross-reference: NCI:C4055
has cross-reference: SNOMEDCT_US_2020_03_01:724171006
has cross-reference: UMLS_CUI:C0281784
alternative_term: meningioma, benign
has_obo_namespace: disease_ontology
id: DOID:4587
in subset: NCIthesaurus

lymphoplasmacyte-rich meningioma
type: Class
subclass of: meningioma
imported from: doid.owl
has cross-reference: NCI:C4720
has cross-reference: SNOMEDCT_US_2020_03_01:19453003
has cross-reference: UMLS_CUI:C0431119
alternative_term: Lymphoplasmacyte-Rich meningioma
alternative_term: Lymphoplasmocyte-rich meningioma
has_obo_namespace: disease_ontology
id: DOID:4591
in subset: NCIthesaurus

epidermolytic hyperkeratosis
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: GARD:1039
has cross-reference: ICD10CM:Q80.3
has cross-reference: MESH:D017488
has cross-reference: NCI:C62569
has cross-reference: OMIM:113800
has cross-reference: SNOMEDCT_US_2020_03_01:20512000
has cross-reference: UMLS_CUI:C0079153
alternative_term: Bullous ichthyosiform erythroderma
alternative_term: Epidermolytic palmoplantar hyperkeratosis
alternative_term: bullous congenital ichthyosiform erythroderma
has_obo_namespace: disease_ontology
id: DOID:4603
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

bile duct cancer
type: Class
subclass of: bile duct disease
subclass of: biliary tract cancer
textual definition: A biliary tract cancer that is located_in the bile duct.
imported from: doid.owl
has_alternative_id: DOID:10019
has cross-reference: ICD10CM:C24.0
has cross-reference: ICD9CM:156.1
has cross-reference: MESH:D001650
has cross-reference: NCI:C2898
has cross-reference: NCI:C7483
has cross-reference: SNOMEDCT_US_2020_03_01:93790004
has cross-reference: UMLS_CUI:C0005396
has cross-reference: UMLS_CUI:C0153453
alternative_term: Ca extrahepatic bile ducts
alternative_term: bile duct tumor
alternative_term: malignant neoplasm of the extrahepatic bile duct
has_obo_namespace: disease_ontology
id: DOID:4606
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

biliary tract cancer
type: Class
subclass of: hepatobiliary system cancer
textual definition: A hepatobiliary system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct.
imported from: doid.owl
has_alternative_id: DOID:8092
has cross-reference: GARD:5924
has cross-reference: GARD:9304
has cross-reference: ICD10CM:C24.9
has cross-reference: ICD9CM:156.9
has cross-reference: MESH:D001661
has cross-reference: SNOMEDCT_US_2020_03_01:126853008
has cross-reference: SNOMEDCT_US_2020_03_01:93688006
has cross-reference: UMLS_CUI:C0005426
has cross-reference: UMLS_CUI:C0750952
alternative_term: malignant tumour of biliary tract
has_obo_namespace: disease_ontology
id: DOID:4607

muscle benign neoplasm
type: Class
subclass of: musculoskeletal system benign neoplasm
subclass of: muscular disease
imported from: doid.owl
has_alternative_id: DOID:2692
has cross-reference: MESH:D009379
has cross-reference: MESH:D019042
has cross-reference: NCI:C4063
has cross-reference: SNOMEDCT_US_2020_03_01:115228006
has cross-reference: UMLS_CUI:C0027664
has cross-reference: UMLS_CUI:C0282606
alternative_term: Myomatous neoplasm
alternative_term: Myomatous tumor
alternative_term: muscle neoplasm
alternative_term: muscle tissue neoplasm
alternative_term: neoplasm of muscle
has_obo_namespace: disease_ontology
id: DOID:461
in subset: NCIthesaurus

intestinal benign neoplasm
type: Class
subclass of: gastrointestinal system benign neoplasm
subclass of: intestinal disease
textual definition: A gastrointestinal system benign neoplasm that is located_in the intestine.
imported from: doid.owl
has cross-reference: MESH:D007414
has cross-reference: NCI:C3141
has cross-reference: SNOMEDCT_US_2020_03_01:126769007
has cross-reference: UMLS_CUI:C0021841
alternative_term: intestinal tumors
alternative_term: intestine growth
alternative_term: neoplasm of intestinal tract
has_obo_namespace: disease_ontology
id: DOID:4610
in subset: NCIthesaurus

ulnar neuropathy
type: Class
subclass of: mononeuropathy
imported from: doid.owl
has cross-reference: MESH:D020424
has cross-reference: SNOMEDCT_US_2020_03_01:55802003
has cross-reference: UMLS_CUI:C0154743
alternative_term: Ulnar neuropathy
has_obo_namespace: disease_ontology
id: DOID:4613

holoprosencephaly
type: Class
subclass of: syndrome
subclass of: congenital nervous system abnormality
textual definition: A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies.
imported from: doid.owl
has cross-reference: GARD:6665
has cross-reference: ICD10CM:Q04.2
has cross-reference: MESH:D016142
has cross-reference: NCI:C74988
has cross-reference: OMIM:PS236100
has cross-reference: ORDO:2162
has cross-reference: SNOMEDCT_US_2020_03_01:30915001
has cross-reference: UMLS_CUI:C0079541
alternative_term: Holoprosencephaly sequence
has_obo_namespace: disease_ontology
id: DOID:4621
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Ollier disease
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.
imported from: doid.owl
has cross-reference: GARD:7251
has cross-reference: ICD10CM:Q78.4
has cross-reference: MESH:D004687
has cross-reference: NCI:C3213
has cross-reference: OMIM:166000
has cross-reference: ORDO:296
has cross-reference: SNOMEDCT_US_2020_03_01:46041001
has cross-reference: UMLS_CUI:C0024454
alternative_term: DYSCHONDROPLASIA
alternative_term: ENCHONDROMATOSIS, MULTIPLE
alternative_term: Enchondromatosis with haemangiomata
alternative_term: Kast's syndrome
alternative_term: OSTEOCHONDROMATOSIS
has_obo_namespace: disease_ontology
id: DOID:4624
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hydranencephaly
type: Class
subclass of: anencephaly
imported from: doid.owl
has cross-reference: GARD:6681
has cross-reference: ICD10CM:Q04.3
has cross-reference: MESH:D006832
has cross-reference: NCI:C98949
has cross-reference: SNOMEDCT_US_2020_03_01:30023002
has cross-reference: UMLS_CUI:C0020225
has_obo_namespace: disease_ontology
id: DOID:4626
in subset: NCIthesaurus

ideomotor apraxia
type: Class
subclass of: apraxia
imported from: doid.owl
has cross-reference: MESH:D020240
has cross-reference: SNOMEDCT_US_2020_03_01:39746003
has cross-reference: UMLS_CUI:C0234523
alternative_term: Classic apraxia
alternative_term: Ideomotor dyspraxia
alternative_term: Limb-kinetic apraxia
alternative_term: Transcortical apraxia
has_obo_namespace: disease_ontology
id: DOID:4627
in subset: DO FlyBase slim

cervical adenitis
type: Class
subclass of: lymphadenitis
imported from: doid.owl
has cross-reference: NCI:C26937
has cross-reference: SNOMEDCT_US_2020_03_01:3502005
has cross-reference: UMLS_CUI:C0149642
alternative_term: cervical Lymphadenitis
alternative_term: cervical lymphadenitis
has_obo_namespace: disease_ontology
id: DOID:4637
in subset: NCIthesaurus

suppurative lymphadenitis
type: Class
subclass of: lymphadenitis
imported from: doid.owl
has cross-reference: NCI:C27135
has cross-reference: SNOMEDCT_US_2020_03_01:48573006
has cross-reference: UMLS_CUI:C0392051
alternative_term: Suppurative lymphadenopathy
has_obo_namespace: disease_ontology
id: DOID:4639
in subset: NCIthesaurus

epidermolysis bullosa simplex
type: Class
subclass of: epidermolysis bullosa
textual definition: An epidermolysis bullosa that is characterized by recurrent blistering at the level of the epidermis secondary to minor trauma, which can cause limited wounds, dehydration, electrolyte abnormalities, severe infection, among other issues, and has_material_basis_in mutation in the KRT5, KRT14, or PLEC genes, which encode keratin and plectin proteins that provide resilience in skin.
imported from: doid.owl
has cross-reference: GARD:10752
has cross-reference: ICD10CM:Q81.0
has cross-reference: MESH:D016110
has cross-reference: NCI:C84692
has cross-reference: OMIM:601001
has cross-reference: OMIM:615425
has cross-reference: ORDO:304
has cross-reference: SNOMEDCT_US_2020_03_01:205585003
has cross-reference: UMLS_CUI:C0079298
alternative_term: Epidermolysis bullosa simplex
has_obo_namespace: disease_ontology
id: DOID:4644
in subset: NCIthesaurus

retinal cancer
type: Class
subclass of: ocular cancer
subclass of: retinal disease
imported from: doid.owl
has_alternative_id: DOID:770
has cross-reference: ICD10CM:C69.2
has cross-reference: ICD9CM:190.5
has cross-reference: MESH:D019572
has cross-reference: NCI:C3216
has cross-reference: NCI:C4800
has cross-reference: SNOMEDCT_US_2020_03_01:127002001
has cross-reference: SNOMEDCT_US_2020_03_01:93987004
has cross-reference: UMLS_CUI:C0024622
has cross-reference: UMLS_CUI:C0524801
alternative_term: Retinal tumor
alternative_term: malignant Retinal neoplasm
alternative_term: malignant neoplasm of retina
alternative_term: malignant tumor of retina
alternative_term: neoplasm of retina
has_obo_namespace: disease_ontology
id: DOID:4645
in subset: NCIthesaurus

familial retinoblastoma
type: Class
subclass of: retinoblastoma
imported from: doid.owl
has cross-reference: MESH:D012175
has cross-reference: NCI:C8495
has cross-reference: UMLS_CUI:C0751483
alternative_term: Hereditary Retinoblastoma
has_obo_namespace: disease_ontology
id: DOID:4648
in subset: NCIthesaurus

bilateral retinoblastoma
type: Class
subclass of: retinoblastoma
textual definition: A retinoblastoma that develops in both eyes.
imported from: doid.owl
has cross-reference: NCI:C8713
has cross-reference: UMLS_CUI:C0854914
has_obo_namespace: disease_ontology
id: DOID:4650
in subset: NCIthesaurus

indolent systemic mastocytosis
type: Class
subclass of: systemic mastocytosis
imported from: doid.owl
has cross-reference: ICD10CM:D47.02
has cross-reference: MESH:D034721
has cross-reference: NCI:C9286
has cross-reference: SNOMEDCT_US_2020_03_01:70910003
has cross-reference: UMLS_CUI:C0272203
alternative_term: ISM
alternative_term: Indolent systemic mastocytosis
has_obo_namespace: disease_ontology
id: DOID:4660
in subset: NCIthesaurus

multiple chemical sensitivity
type: Class
subclass of: syndrome
textual definition: A syndrome that is an adverse physical reaction to low levels of many common chemicals.
imported from: doid.owl
has cross-reference: MESH:D018777
has cross-reference: SNOMEDCT_US_2020_03_01:702772003
has cross-reference: UMLS_CUI:C0242992
alternative_term: 20th century disease
alternative_term: chemical AIDS
alternative_term: environmental illness
alternative_term: idiopathic environmental illness
alternative_term: total allergy syndrome
has_obo_namespace: disease_ontology
id: DOID:4661

androgen insensitivity syndrome
type: Class
subclass of: disorder of sexual development
textual definition: A disorder of sexual developement that is characterized by the inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup.
imported from: doid.owl
has_alternative_id: DOID:4672
has cross-reference: GARD:5803
has cross-reference: ICD10CM:E34.5
has cross-reference: ICD9CM:259.51
has cross-reference: NCI:C27226
has cross-reference: OMIM:300068
has cross-reference: ORDO:754
has cross-reference: SNOMEDCT_US_2020_03_01:12313004
has cross-reference: UMLS_CUI:C0039585
alternative_term: Androgen resistance syndrome
alternative_term: Androgen-Insensitivity Syndrome
alternative_term: Feminisation - testicular
alternative_term: Goldberg - Maxwell syndrome
alternative_term: Goldberg-Maxwell syndrome
alternative_term: testicular Feminization syndrome
alternative_term: testicular feminization
has_obo_namespace: disease_ontology
id: DOID:4674
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].
has narrower match: MESH:D013734

keratitis
type: Class
subclass of: corneal disease
textual definition: A corneal disease that is characterized by inflammation of the cornea.
imported from: doid.owl
has cross-reference: ICD10CM:H16
has cross-reference: ICD9CM:370
has cross-reference: MESH:D007634
has cross-reference: NCI:C26805
has cross-reference: SNOMEDCT_US_2020_03_01:193757003
has cross-reference: UMLS_CUI:C0022568
has_obo_namespace: disease_ontology
id: DOID:4677
in subset: NCIthesaurus

intramuscular hemangioma
type: Class
subclass of: hemangioma
subclass of: muscle benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D006391
has cross-reference: NCI:C3699
has cross-reference: SNOMEDCT_US_2020_03_01:54249004
has cross-reference: UMLS_CUI:C0205789
alternative_term: Intramuscular Angioma
alternative_term: Intramuscular hemangioma
has_obo_namespace: disease_ontology
id: DOID:468
in subset: NCIthesaurus

breast metaplastic carcinoma
type: Class
subclass of: breast carcinoma
textual definition: A breast carcinoma that represents a mixed group of malignant neoplasms characterized by the histologic presence of two or more cellular types.
imported from: doid.owl
has cross-reference: GARD:10804
has cross-reference: NCI:C5164
has cross-reference: SNOMEDCT_US_2020_03_01:763479005
has cross-reference: UMLS_CUI:C1334708
alternative_term: Metaplastic carcinoma of the breast
has_obo_namespace: disease_ontology
has_related_synonym: metaplastic carcinoma of breast
id: DOID:4680
in subset: NCIthesaurus

extrahepatic bile duct carcinoma
type: Class
subclass of: bile duct carcinoma
imported from: doid.owl
has cross-reference: NCI:C3860
has cross-reference: SNOMEDCT_US_2020_03_01:372101000
has cross-reference: UMLS_CUI:C0238019
alternative_term: carcinoma of extrahepatic bile duct
alternative_term: extrahepatic bile duct cancer
has_obo_namespace: disease_ontology
id: DOID:4682
in subset: NCIthesaurus

cutaneous mucoepidermoid carcinoma
type: Class
subclass of: skin carcinoma
imported from: doid.owl
has cross-reference: NCI:C4472
has cross-reference: SNOMEDCT_US_2020_03_01:254713002
has cross-reference: UMLS_CUI:C0346019
alternative_term: Mucoepidermoid carcinoma of skin
alternative_term: Mucoepidermoid skin carcinoma
has_obo_namespace: disease_ontology
id: DOID:4683
in subset: NCIthesaurus

endophthalmitis
type: Class
subclass of: globe disease
textual definition: A globe disease that is characterized by inflammation of the inside of the eye.
imported from: doid.owl
has cross-reference: MESH:D009877
has cross-reference: NCI:C34586
has cross-reference: SNOMEDCT_US_2020_03_01:1847009
has cross-reference: UMLS_CUI:C0014236
has_obo_namespace: disease_ontology
id: DOID:4692
in subset: NCIthesaurus

perineurioma
type: Class
subclass of: peripheral nerve sheath neoplasm
imported from: doid.owl
has_alternative_id: DOID:8371
has cross-reference: GARD:12698
has cross-reference: MESH:D018317
has cross-reference: NCI:C4973
has cross-reference: NCI:C6912
has cross-reference: SNOMEDCT_US_2020_03_01:128795001
has cross-reference: UMLS_CUI:C0751691
has cross-reference: UMLS_CUI:C1370657
alternative_term: soft tissue Perineurioma
has_obo_namespace: disease_ontology
id: DOID:4697
in subset: NCIthesaurus

prostate disease
type: Class
subclass of: male reproductive system disease
imported from: doid.owl
has cross-reference: ICD10CM:N42.9
has cross-reference: ICD9CM:602.9
has cross-reference: MESH:D011469
has cross-reference: NCI:C26865
has cross-reference: SNOMEDCT_US_2020_03_01:30281009
has cross-reference: UMLS_CUI:C0033575
has_obo_namespace: disease_ontology
id: DOID:47
in subset: NCIthesaurus

mongolian spot
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: MESH:D049328
has cross-reference: NCI:C3945
has cross-reference: SNOMEDCT_US_2020_03_01:40467008
has cross-reference: UMLS_CUI:C0265985
alternative_term: Mongolian Macula
has_obo_namespace: disease_ontology
id: DOID:4702
in subset: NCIthesaurus

infratentorial cancer
type: Class
subclass of: brain cancer
textual definition: A brain cancer that is located_in the infratentorial region.
imported from: doid.owl
has_alternative_id: DOID:4789
has cross-reference: ICD10CM:C71.7
has cross-reference: MESH:D015192
has cross-reference: NCI:C3139
has cross-reference: NCI:C4966
has cross-reference: UMLS_CUI:C0021432
has cross-reference: UMLS_CUI:C0751593
alternative_term: brain neoplasm, Infratentorial
alternative_term: malignant Infratentorial tumors
has_obo_namespace: disease_ontology
id: DOID:4706
in subset: NCIthesaurus

foramen magnum meningioma
type: Class
subclass of: meningioma
subclass of: skull base meningioma
imported from: doid.owl
has cross-reference: NCI:C5280
has cross-reference: UMLS_CUI:C1333630
alternative_term: meningioma of the Foramen Magnum
has_obo_namespace: disease_ontology
id: DOID:4708
in subset: NCIthesaurus

skin hemangioma
type: Class
subclass of: hemangioma
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C4905
has cross-reference: SNOMEDCT_US_2020_03_01:254773009
has cross-reference: UMLS_CUI:C0687140
alternative_term: Angioma of the skin
alternative_term: Angiomatous naevus of skin
has_obo_namespace: disease_ontology
id: DOID:471
in subset: NCIthesaurus

intracranial hypotension
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by low pressure inside the skull, and thus in the brain tissue and cerebrospinal fluid; may occur as a result of an occult or iatrogenically caused leak of CSF into another body cavity; may result in the downward displacement of the cerebellar tonsils through the foramen magnum or Chiari malformation; has_symptom orthostatic headache; other symptoms are related to compression of cranial nerves due to brain sagging.
imported from: doid.owl
has cross-reference: MESH:D019585
has cross-reference: SNOMEDCT_US_2020_03_01:433691000124104
has cross-reference: UMLS_CUI:C0524812
has_obo_namespace: disease_ontology
id: DOID:4723

brain edema
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by excess accumulation of fluid in the intracellular and/or extracellular spaces of the brain, has_symptom nausea, has_symptom vomiting, has_symptom blurred vision, has_symptom seizure, has_symptom coma.
imported from: doid.owl
has cross-reference: MESH:D001929
has cross-reference: SNOMEDCT_US_2020_03_01:85974009
has cross-reference: UMLS_CUI:C1527311
alternative_term: intracranial swelling
alternative_term: wet brain
has_obo_namespace: disease_ontology
id: DOID:4724

somatoform disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.
imported from: doid.owl
has_alternative_id: DOID:10133
has_alternative_id: DOID:144
has cross-reference: ICD10CM:F45
has cross-reference: ICD10CM:F45.0
has cross-reference: ICD9CM:300.8
has cross-reference: ICD9CM:300.81
has cross-reference: MESH:D013001
has cross-reference: NCI:C34956
has cross-reference: SNOMEDCT_US_2020_03_01:192430009
has cross-reference: SNOMEDCT_US_2020_03_01:60368009
has cross-reference: UMLS_CUI:C0037650
has cross-reference: UMLS_CUI:C0520482
alternative_term: physiological malfunction arising from mental factor
alternative_term: psychophysiologic disorder
alternative_term: psychosomatic disorder
has_obo_namespace: disease_ontology
id: DOID:4737
in subset: NCIthesaurus

histiocytoid hemangioma
type: Class
subclass of: hemangioma
imported from: doid.owl
has cross-reference: MESH:D006391
has cross-reference: NCI:C4298
has cross-reference: SNOMEDCT_US_2020_03_01:253054009
has cross-reference: UMLS_CUI:C0205788
alternative_term: Angiolymphoid hyperplasia with eosinophilia
alternative_term: epithelioid haemangioma
alternative_term: epithelioid hemangioma
has_obo_namespace: disease_ontology
id: DOID:474
in subset: NCIthesaurus

placenta accreta
type: Class
subclass of: placenta disease
textual definition: A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.
imported from: doid.owl
has cross-reference: ICD10CM:O43.21
has cross-reference: MESH:D010921
has cross-reference: NCI:C26856
has cross-reference: SNOMEDCT_US_2020_03_01:70129008
has cross-reference: UMLS_CUI:C0032044
has_obo_namespace: disease_ontology
id: DOID:4744
in subset: NCIthesaurus

striatonigral degeneration
type: Class
subclass of: multiple system atrophy
imported from: doid.owl
has cross-reference: ICD10CM:G23.2
has cross-reference: MESH:D020955
has cross-reference: NCI:C125695
has cross-reference: OMIM:271930
has cross-reference: OMIM:500003
has cross-reference: OMIM:609161
has cross-reference: SNOMEDCT_US_2020_03_01:29618004
has cross-reference: UMLS_CUI:C0270733
has_obo_namespace: disease_ontology
id: DOID:4751
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

multiple system atrophy
type: Class
subclass of: synucleinopathy
imported from: doid.owl
has_alternative_id: DOID:11510
has cross-reference: GARD:7079
has cross-reference: MESH:D012791
has cross-reference: MESH:D019578
has cross-reference: NCI:C84909
has cross-reference: SNOMEDCT_US_2020_03_01:16576004
has cross-reference: SNOMEDCT_US_2020_03_01:230297002
has cross-reference: UMLS_CUI:C0037019
has cross-reference: UMLS_CUI:C0393571
alternative_term: Multiple system atrophy
alternative_term: Shy-Drager syndrome
has_obo_namespace: disease_ontology
id: DOID:4752
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

pulmonary blastoma
type: Class
subclass of: blastoma
subclass of: lung cancer
subclass of: pleural disease
textual definition: A lung cancer that has_material_basis_in tissues of the lung and has_material_basis_in pleural tissues. It is most commonly effects children.
imported from: doid.owl
has cross-reference: MESH:D018202
has cross-reference: NCI:C3732
has cross-reference: SNOMEDCT_US_2020_03_01:189815007
has cross-reference: UMLS_CUI:C0206629
alternative_term: Blastoma of lung
has_obo_namespace: disease_ontology
id: DOID:4765
in subset: NCIthesaurus

pleuropulmonary blastoma
type: Class
subclass of: pulmonary blastoma
textual definition: A pulmonary blastoma that derives_from the lung or pleural cavity.
imported from: doid.owl
has cross-reference: GARD:8757
has cross-reference: MESH:C537516
has cross-reference: NCI:C5669
has cross-reference: OMIM:601200
has cross-reference: SNOMEDCT_US_2020_03_01:707670009
has cross-reference: UMLS_CUI:C1266144
alternative_term: Pleuropulmonary blastoma
has_obo_namespace: disease_ontology
id: DOID:4769
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

congenital mesoblastic nephroma
type: Class
subclass of: physical disorder
subclass of: kidney cancer
textual definition: A kidney cancer that is characterized by the presence of fibroblastic cells.
imported from: doid.owl
has_alternative_id: DOID:4772
has cross-reference: GARD:1493
has cross-reference: MESH:D018201
has cross-reference: NCI:C6569
has cross-reference: UMLS_CUI:C1332965
has_obo_namespace: disease_ontology
id: DOID:4773
in subset: NCIthesaurus

diffuse glomerulonephritis
type: Class
subclass of: glomerulonephritis
imported from: doid.owl
has cross-reference: NCI:C35799
has cross-reference: UMLS_CUI:C0859036
has_obo_namespace: disease_ontology
id: DOID:4781
in subset: NCIthesaurus

intracranial primitive neuroectodermal tumor
type: Class
subclass of: central nervous system primitive neuroectodermal neoplasm
imported from: doid.owl
has cross-reference: NCI:C5817
has cross-reference: UMLS_CUI:C1334246
alternative_term: intracranial PNET
has_obo_namespace: disease_ontology
id: DOID:4788
in subset: NCIthesaurus

angiokeratoma
type: Class
subclass of: skin hemangioma
imported from: doid.owl
has_alternative_id: DOID:665
has cross-reference: MESH:D000794
has cross-reference: NCI:C2874
has cross-reference: NCI:C4488
has cross-reference: SNOMEDCT_US_2020_03_01:254788004
has cross-reference: SNOMEDCT_US_2020_03_01:26810009
has cross-reference: UMLS_CUI:C0002985
has cross-reference: UMLS_CUI:C0346075
alternative_term: Angiokeratoma
alternative_term: Angiokeratoma of skin
alternative_term: Cutaneous Angiokeratoma
alternative_term: skin angiokeratoma
has_obo_namespace: disease_ontology
id: DOID:479
in subset: NCIthesaurus

medulloepithelioma
type: Class
subclass of: central nervous system primitive neuroectodermal neoplasm
imported from: doid.owl
has cross-reference: MESH:D018242
has cross-reference: NCI:C4327
has cross-reference: SNOMEDCT_US_2020_03_01:715903004
has cross-reference: UMLS_CUI:C0334596
alternative_term: Diktyoma, malignant
alternative_term: Medulloepithelioma
alternative_term: Medulloepithelioma, central nervous system
has_obo_namespace: disease_ontology
id: DOID:4790
in subset: NCIthesaurus

supratentorial primitive neuroectodermal tumor
type: Class
subclass of: supratentorial cancer
imported from: doid.owl
has cross-reference: GARD:7366
has cross-reference: NCI:C6968
has cross-reference: SNOMEDCT_US_2020_03_01:699318007
has cross-reference: UMLS_CUI:C1336538
alternative_term: Supratentorial PNET
has_obo_namespace: disease_ontology
id: DOID:4791
in subset: NCIthesaurus

ependymoblastoma
type: Class
subclass of: central nervous system primitive neuroectodermal neoplasm
imported from: doid.owl
has cross-reference: MESH:D018242
has cross-reference: NCI:C4915
has cross-reference: SNOMEDCT_US_2020_03_01:253070006
has cross-reference: UMLS_CUI:C0700367
has_obo_namespace: disease_ontology
id: DOID:4794
in subset: NCIthesaurus

space motion sickness
type: Class
subclass of: motion sickness
imported from: doid.owl
has cross-reference: MESH:D018489
has cross-reference: SNOMEDCT_US_2020_03_01:21162009
has cross-reference: UMLS_CUI:C0242700
has_obo_namespace: disease_ontology
id: DOID:4796

SM-AHNMD
type: Class
subclass of: systemic mastocytosis
imported from: doid.owl
has cross-reference: NCI:C9284
has cross-reference: SNOMEDCT_US_2020_03_01:397357000
has cross-reference: UMLS_CUI:C1301365
alternative_term: systemic mastocytosis with associated clonal haematological non-mast cell lineage disease
alternative_term: systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease
has_obo_namespace: disease_ontology
id: DOID:4797
in subset: NCIthesaurus

male reproductive system disease
type: Class
subclass of: reproductive system disease
textual definition: A reproductive system disease that affects male reproductive organs.
imported from: doid.owl
has cross-reference: ICD10CM:N50.9
has cross-reference: ICD9CM:608.9
has cross-reference: MESH:D005832
has cross-reference: SNOMEDCT_US_2020_03_01:64557000
has cross-reference: UMLS_CUI:C0017412
has_obo_namespace: disease_ontology
id: DOID:48

movement disease
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by a clinical syndrome of either hyperkinetic movement or hyperkinetic movement unrelated to weakness or spasticity.
imported from: doid.owl
has cross-reference: MESH:D009069
has cross-reference: NCI:C116757
has cross-reference: SNOMEDCT_US_2020_03_01:60342002
has cross-reference: UMLS_CUI:C0026650
has_obo_namespace: disease_ontology
id: DOID:480
in subset: NCIthesaurus

cerebrotendinous xanthomatosis
type: Class
subclass of: xanthomatosis
textual definition: A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma.
imported from: doid.owl
has cross-reference: GARD:5622
has cross-reference: MESH:D019294
has cross-reference: NCI:C84628
has cross-reference: OMIM:213700
has cross-reference: SNOMEDCT_US_2020_03_01:63246000
has cross-reference: UMLS_CUI:C0238052
alternative_term: Cholestanol storage disease
has_obo_namespace: disease_ontology
id: DOID:4810
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

ganglioneuroma
type: Class
subclass of: autonomic nervous system benign neoplasm
textual definition: An autonomic nervous system benign neoplasm that is characterized by the presence of mature ganglion cells and a mature Schwannian stroma and arises from the sympathetic trunk in the mediastinum.
imported from: doid.owl
has cross-reference: MESH:D005729
has cross-reference: NCI:C3049
has cross-reference: NCI:C42065
has cross-reference: SNOMEDCT_US_2020_03_01:189929007
has cross-reference: UMLS_CUI:C0017075
has cross-reference: UMLS_CUI:C1513025
has_obo_namespace: disease_ontology
id: DOID:4817
in subset: NCIthesaurus

cavernous hemangioma
type: Class
subclass of: vascular hemostatic disease
imported from: doid.owl
has cross-reference: ICD10CM:D18.0
has cross-reference: MESH:D006392
has cross-reference: NCI:C3086
has cross-reference: SNOMEDCT_US_2020_03_01:67668002
has cross-reference: UMLS_CUI:C0018920
alternative_term: Cavernoma
alternative_term: Cavernous haemangioma
alternative_term: Cavernous hemangioma
has_obo_namespace: disease_ontology
id: DOID:483
in subset: NCIthesaurus

adenosquamous carcinoma
type: Class
subclass of: squamous cell carcinoma
textual definition: A squamous cell carcinoma that contains squamous cells and gland-like cells.
imported from: doid.owl
has cross-reference: MESH:D018196
has cross-reference: NCI:C3727
has cross-reference: SNOMEDCT_US_2020_03_01:403902008
has cross-reference: UMLS_CUI:C0206623
alternative_term: Adenosquamous carcinoma
alternative_term: Adenosquamous cell carcinoma
alternative_term: mixed adenocarcinoma and squamous carcinoma
has_obo_namespace: disease_ontology
id: DOID:4830
in subset: NCIthesaurus

Gorham's disease
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.
imported from: doid.owl
has cross-reference: GARD:6542
has cross-reference: MESH:D010015
has cross-reference: SNOMEDCT_US_2020_03_01:240161003
has cross-reference: UMLS_CUI:C0029436
alternative_term: Disappearing bone disease
alternative_term: Gorham disease
alternative_term: essential osteolysis
alternative_term: massive osteolysis
alternative_term: phantom bone disease
has_obo_namespace: disease_ontology
has_related_synonym: Gorham-Stout Syndrome
id: DOID:4837

myoepithelial carcinoma
type: Class
subclass of: carcinoma
textual definition: A carcinoma that derives_from myoepithelial cells.
imported from: doid.owl
has cross-reference: GARD:10558
has cross-reference: NCI:C7596
has cross-reference: SNOMEDCT_US_2020_03_01:24292006
has cross-reference: UMLS_CUI:C0334699
has_obo_namespace: disease_ontology
id: DOID:4838
in subset: NCIthesaurus

vascular hemostatic disease
type: Class
subclass of: hemorrhagic disease
imported from: doid.owl
has cross-reference: MESH:D020141
has cross-reference: SNOMEDCT_US_2020_03_01:21112004
has cross-reference: UMLS_CUI:C0600502
has_obo_namespace: disease_ontology
id: DOID:484

sebaceous carcinoma
type: Class
subclass of: carcinoma
subclass of: skin cancer
subclass of: DOID 9098
imported from: doid.owl
has cross-reference: ICD10CM:C44
has cross-reference: NCI:C8409
has cross-reference: SNOMEDCT_US_2020_03_01:188083002
has cross-reference: UMLS_CUI:C1382026
alternative_term: malignant Sebaceous tumor
alternative_term: malignant neoplasm of sebaceous gland
has_obo_namespace: disease_ontology
id: DOID:4840
in subset: NCIthesaurus

subependymal glioma
type: Class
subclass of: benign ependymoma
imported from: doid.owl
has cross-reference: MESH:D018315
has cross-reference: NCI:C3795
has cross-reference: SNOMEDCT_US_2020_03_01:4553004
has cross-reference: UMLS_CUI:C0206725
alternative_term: Subependymal astrocytoma
alternative_term: WHO grade I Ependymal tumor
alternative_term: mixed subependymoma-ependymoma
has_obo_namespace: disease_ontology
id: DOID:4843
in subset: NCIthesaurus

benign ependymoma
type: Class
subclass of: benign glioma
imported from: doid.owl
has cross-reference: MESH:D004806
has cross-reference: NCI:C3017
has cross-reference: SNOMEDCT_US_2020_03_01:443643007
has cross-reference: UMLS_CUI:C0014474
alternative_term: WHO grade II Ependymal tumor
alternative_term: epithelial ependymoma
has_obo_namespace: disease_ontology
id: DOID:4844
in subset: NCIthesaurus

pilomyxoid astrocytoma
type: Class
subclass of: astrocytoma
imported from: doid.owl
has cross-reference: NCI:C40315
has cross-reference: SNOMEDCT_US_2020_03_01:388600004
has cross-reference: UMLS_CUI:C1519086
has_obo_namespace: disease_ontology
id: DOID:4845
in subset: NCIthesaurus

cerebellar astrocytoma
type: Class
subclass of: malignant glioma
subclass of: cerebellum cancer
imported from: doid.owl
has cross-reference: NCI:C9475
has cross-reference: UMLS_CUI:C0740480
alternative_term: astrocytoma of Cerebellum
has_obo_namespace: disease_ontology
id: DOID:4848
in subset: NCIthesaurus

pilocytic astrocytoma
type: Class
subclass of: pediatric low-grade glioma
textual definition: A pediatric low-grade glioma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain.
imported from: doid.owl
has cross-reference: GARD:9808
has cross-reference: MESH:D001254
has cross-reference: NCI:C4047
has cross-reference: SNOMEDCT_US_2020_03_01:67859002
has cross-reference: UMLS_CUI:C0334583
alternative_term: Piloid astrocytoma
alternative_term: grade I Astrocytic tumor
has_obo_namespace: disease_ontology
id: DOID:4851
in subset: DO cancer slim
in subset: NCIthesaurus

salivary gland adenoid cystic carcinoma
type: Class
subclass of: salivary gland carcinoma
textual definition: A salivary gland carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.
imported from: doid.owl
has cross-reference: MESH:D003528
has cross-reference: NCI:C2970
has cross-reference: SNOMEDCT_US_2020_03_01:11671000
has cross-reference: UMLS_CUI:C0010606
alternative_term: Cylindroma
alternative_term: adenoid cystic cancer
alternative_term: adenoid cystic carcinoma
has_obo_namespace: disease_ontology
id: DOID:4866
in subset: DO cancer slim
in subset: NCIthesaurus

anterior horn cell disease
type: Class
subclass of: spinal muscular atrophy
imported from: doid.owl
has cross-reference: ICD9CM:335
has cross-reference: MESH:D016472
has cross-reference: SNOMEDCT_US_2020_03_01:267693003
has cross-reference: UMLS_CUI:C0154681
has_obo_namespace: disease_ontology
id: DOID:4873

Colorado tick fever
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue.
imported from: doid.owl
has cross-reference: ICD10CM:A93.2
has cross-reference: MESH:D003121
has cross-reference: SNOMEDCT_US_2020_03_01:186607005
has cross-reference: UMLS_CUI:C0009400
alternative_term: Tick fever, American mountain
has_obo_namespace: disease_ontology
id: DOID:4885
in subset: tick-borne infectious disease

lymph node tuberculosis
type: Class
subclass of: extrapulmonary tuberculosis
subclass of: DOID 9942
textual definition: An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.
imported from: doid.owl
has_alternative_id: DOID:4888
has cross-reference: ICD10CM:A18.2
has cross-reference: MESH:D014388
has cross-reference: MESH:D018601
has cross-reference: NCI:C26896
has cross-reference: SNOMEDCT_US_2020_03_01:10893003
has cross-reference: UMLS_CUI:C0041316
has cross-reference: UMLS_CUI:C0242830
alternative_term: Lymph Node Tuberculosis
alternative_term: Tuberculous adenitis
alternative_term: Tuberculous lymphadenopathy
alternative_term: king's evil
alternative_term: scrofula
has_obo_namespace: disease_ontology
id: DOID:4889
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

bile duct adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: bile duct carcinoma
textual definition: A bile duct carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C27813
has cross-reference: SNOMEDCT_US_2020_03_01:70179006
has cross-reference: UMLS_CUI:C1370800
has_obo_namespace: disease_ontology
id: DOID:4896
in subset: DO cancer slim
in subset: NCIthesaurus

bile duct carcinoma
type: Class
subclass of: carcinoma
subclass of: bile duct cancer
textual definition: A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: MESH:D001650
has cross-reference: NCI:C27814
has cross-reference: SNOMEDCT_US_2020_03_01:70179006
has cross-reference: UMLS_CUI:C0740277
has_obo_namespace: disease_ontology
id: DOID:4897
in subset: NCIthesaurus

hemangioma of lung
type: Class
subclass of: hemangioma
subclass of: lung benign neoplasm
imported from: doid.owl
alternative_term: pulmonary hemangioma
has_obo_namespace: disease_ontology
id: DOID:490

appendix carcinoma
type: Class
subclass of: appendix cancer
subclass of: carcinoma
textual definition: An appendix cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C9330
has cross-reference: SNOMEDCT_US_2020_03_01:269541000
has cross-reference: UMLS_CUI:C0728951
alternative_term: Ca appendix
alternative_term: carcinoma of appendix
has_obo_namespace: disease_ontology
id: DOID:4902
in subset: NCIthesaurus

pancreatic carcinoma
type: Class
subclass of: pancreatic cancer
subclass of: carcinoma
textual definition: A pancreas cancer that derives_from epithelial cells located_in the pancreas.
imported from: doid.owl
has cross-reference: EFO:0002618
has cross-reference: MESH:C562463
has cross-reference: NCI:C3850
has cross-reference: OMIM:260350
has cross-reference: SNOMEDCT_US_2020_03_01:154475002
has cross-reference: UMLS_CUI:C0235974
alternative_term: Exocrine pancreas carcinoma
alternative_term: carcinoma of pancreas
has_obo_namespace: disease_ontology
has_related_synonym: Pancreatic carcinoma, familial
has_related_synonym: exocrine cancer
id: DOID:4905
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

small intestine adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: small intestine carcinoma
textual definition: A small intestine carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: GARD:13090
has cross-reference: NCI:C7888
has cross-reference: SNOMEDCT_US_2020_03_01:424440001
has cross-reference: UMLS_CUI:C0278803
alternative_term: small intestinal adenocarcinoma
has_obo_namespace: disease_ontology
has_related_synonym: adenocarcinoma of small Intestine
id: DOID:4906
in subset: NCIthesaurus

small intestine carcinoma
type: Class
subclass of: small intestine cancer
subclass of: carcinoma
textual definition: A small intestine cancer that develops from epithelial cells and is located_in the small intestine.
imported from: doid.owl
has cross-reference: NCI:C7724
has cross-reference: UMLS_CUI:C0238196
alternative_term: small intestinal carcinoma
has_obo_namespace: disease_ontology
has_related_synonym: cancer of the small bowel
has_related_synonym: small bowel cancer
id: DOID:4907
in subset: NCIthesaurus

anal carcinoma
type: Class
subclass of: anus cancer
subclass of: carcinoma
textual definition: A anus cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the anus.
imported from: doid.owl
has cross-reference: MESH:D001005
has cross-reference: NCI:C9291
has cross-reference: SNOMEDCT_US_2020_03_01:187762000
has cross-reference: UMLS_CUI:C0279637
alternative_term: Ca anus
alternative_term: carcinoma of anus
has_obo_namespace: disease_ontology
id: DOID:4908
in subset: NCIthesaurus

pituitary carcinoma
type: Class
subclass of: pituitary cancer
subclass of: carcinoma
imported from: doid.owl
has cross-reference: MESH:D010911
has cross-reference: NCI:C4536
has cross-reference: SNOMEDCT_US_2020_03_01:128665000
has cross-reference: UMLS_CUI:C0346300
alternative_term: carcinoma of the Pituitary gland
has_obo_namespace: disease_ontology
id: DOID:4916
in subset: NCIthesaurus

renal pelvis carcinoma
type: Class
subclass of: kidney cancer
subclass of: carcinoma
imported from: doid.owl
has_alternative_id: DOID:12343
has cross-reference: ICD10CM:C65
has cross-reference: ICD9CM:189.1
has cross-reference: NCI:C6142
has cross-reference: NCI:C7525
has cross-reference: SNOMEDCT_US_2020_03_01:363457009
has cross-reference: UMLS_CUI:C0153618
has cross-reference: UMLS_CUI:C1335749
alternative_term: carcinoma of kidney Pelvis
alternative_term: malignant neoplasm of renal pelvis
alternative_term: malignant renal Pelvis neoplasm
alternative_term: malignant tumor of renal pelvis
alternative_term: renal pelvis cancer
has_obo_namespace: disease_ontology
id: DOID:4919
in subset: NCIthesaurus

eccrine sweat gland cancer
type: Class
subclass of: sweat gland cancer
imported from: doid.owl
has cross-reference: NCI:C5559
has cross-reference: UMLS_CUI:C1334577
alternative_term: malignant Eccrine tumor
alternative_term: malignant eccrine skin neoplasm
has_obo_namespace: disease_ontology
id: DOID:4921
in subset: NCIthesaurus

thymus adenocarcinoma
type: Class
subclass of: adenocarcinoma
subclass of: thymic carcinoma
textual definition: A thymic carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: NCI:C6459
has cross-reference: UMLS_CUI:C1336743
alternative_term: adenocarcinoma of the Thymus
has_obo_namespace: disease_ontology
id: DOID:4923
in subset: NCIthesaurus

Klatskin's tumor
type: Class
subclass of: intrahepatic cholangiocarcinoma
textual definition: An intrahepatic cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts.
imported from: doid.owl
has_alternative_id: DOID:5246
has cross-reference: GARD:10175
has cross-reference: MESH:D018285
has cross-reference: NCI:C36077
has cross-reference: SNOMEDCT_US_2020_03_01:253017000
has cross-reference: UMLS_CUI:C0206702
alternative_term: Klatskin tumor
alternative_term: Klatskin tumour
alternative_term: Klatskin's tumour
alternative_term: Perihilar extrahepatic bile duct carcinoma
alternative_term: hilar cholangiocarcinoma
alternative_term: hilar cholangiocellular carcinoma
has_obo_namespace: disease_ontology
id: DOID:4927
in subset: NCIthesaurus

intrahepatic cholangiocarcinoma
type: Class
subclass of: cholangiocarcinoma
imported from: doid.owl
has cross-reference: GARD:6042
has cross-reference: ICD10CM:C22.1
has cross-reference: MESH:D018281
has cross-reference: NCI:C35417
has cross-reference: SNOMEDCT_US_2020_03_01:109842005
has cross-reference: UMLS_CUI:C0345905
alternative_term: Intrahepatic bile duct carcinoma
alternative_term: peripheral Cholangiocarcinoma
has_obo_namespace: disease_ontology
id: DOID:4928
in subset: NCIthesaurus

ampulla of Vater carcinoma
type: Class
subclass of: ampulla of Vater cancer
subclass of: carcinoma
textual definition: An ampulla of Vater cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C3908
has cross-reference: SNOMEDCT_US_2020_03_01:254609000
has cross-reference: UMLS_CUI:C0262401
alternative_term: ampulla of vater cancer
alternative_term: ampullary carcinoma
alternative_term: carcinoma of ampulla of vater
has_obo_namespace: disease_ontology
id: DOID:4932
in subset: DO cancer slim
in subset: NCIthesaurus

ureter carcinoma
type: Class
subclass of: ureter cancer
subclass of: carcinoma
textual definition: An ureter cancer that is located_in the ureter.
imported from: doid.owl
has cross-reference: NCI:C8993
has cross-reference: UMLS_CUI:C0600079
alternative_term: ureteral carcinoma
has_obo_namespace: disease_ontology
id: DOID:4939
in subset: DO cancer slim
in subset: NCIthesaurus

adenocarcinoma in situ
type: Class
subclass of: DOID 8719
textual definition: An in situ carcinoma that derives_from epithelial cells of glandular origin.
imported from: doid.owl
has cross-reference: MESH:D065311
has cross-reference: NCI:C4123
has cross-reference: SNOMEDCT_US_2020_03_01:51642000
has cross-reference: UMLS_CUI:C0334276
has_obo_namespace: disease_ontology
id: DOID:4943
in subset: NCIthesaurus

cholangiocarcinoma
type: Class
subclass of: bile duct adenocarcinoma
textual definition: A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.
imported from: doid.owl
has_alternative_id: DOID:5249
has cross-reference: ICD10CM:C22.1
has cross-reference: MESH:D018281
has cross-reference: NCI:C4436
has cross-reference: NCI:C8265
has cross-reference: SNOMEDCT_US_2020_03_01:70179006
has cross-reference: UMLS_CUI:C0206698
has cross-reference: UMLS_CUI:C0280725
alternative_term: adult primary Cholangiocarcinoma
alternative_term: adult primary cholangiocellular carcinoma
alternative_term: cholangiosarcoma
has_obo_namespace: disease_ontology
id: DOID:4947
in subset: DO cancer slim
in subset: NCIthesaurus

gallbladder carcinoma
type: Class
subclass of: carcinoma
subclass of: gallbladder cancer
textual definition: A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C3844
has cross-reference: SNOMEDCT_US_2020_03_01:255085003
has cross-reference: UMLS_CUI:C0235782
alternative_term: cancer of the gallbladder
alternative_term: carcinoma gallbladder
alternative_term: carcinoma of gallbladder
has_obo_namespace: disease_ontology
id: DOID:4948
in subset: NCIthesaurus

sclerosing hemangioma
type: Class
subclass of: hemangioma
imported from: doid.owl
has cross-reference: SNOMEDCT_US_2020_03_01:134302009
has cross-reference: UMLS_CUI:C1509148
alternative_term: Sclerosing haemangioma
alternative_term: Sclerosing hemangioma
has_obo_namespace: disease_ontology
id: DOID:495

poliomyelitis
type: Class
subclass of: peripheral nervous system disease
subclass of: DOID 934
textual definition: A viral infectious disease that results in destruction located in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis.
imported from: doid.owl
has cross-reference: GARD:7413
has cross-reference: ICD10CM:A80
has cross-reference: ICD9CM:045
has cross-reference: MESH:D011051
has cross-reference: NCI:C35550
has cross-reference: SNOMEDCT_US_2020_03_01:54839009
has cross-reference: UMLS_CUI:C0032371
has_obo_namespace: disease_ontology
id: DOID:4953
in subset: NCIthesaurus

spindle cell hemangioma
type: Class
subclass of: hemangioma
imported from: doid.owl
has cross-reference: NCI:C4754
has cross-reference: SNOMEDCT_US_2020_03_01:128769003
has cross-reference: UMLS_CUI:C1304508
alternative_term: SCH
has_obo_namespace: disease_ontology
id: DOID:496
in subset: NCIthesaurus

bone marrow cancer
type: Class
subclass of: hematologic cancer
subclass of: bone marrow disease
textual definition: A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow.
imported from: doid.owl
has_alternative_id: DOID:2356
has_alternative_id: DOID:2761
has cross-reference: EFO:0004251
has cross-reference: ICD10CM:D47.1
has cross-reference: MESH:D009196
has cross-reference: SNOMEDCT_US_2020_03_01:128925001
has cross-reference: UMLS_CUI:C0027022
alternative_term: bone Marrow tumor
alternative_term: bone marrow neoplasm
alternative_term: malignant bone Marrow tumor
alternative_term: malignant neoplasm of bone marrow
has_obo_namespace: disease_ontology
id: DOID:4960

bone marrow disease
type: Class
subclass of: hematopoietic system disease
imported from: doid.owl
has cross-reference: MESH:D001855
has cross-reference: NCI:C34433
has cross-reference: SNOMEDCT_US_2020_03_01:127035006
has cross-reference: UMLS_CUI:C0005956
alternative_term: bone marrow disorder
has_obo_namespace: disease_ontology
id: DOID:4961
in subset: NCIthesaurus

neurotic disorder
type: Class
subclass of: anxiety disorder
textual definition: An anxiety disorder that involves discress but neither delusions nor hallucinations.
imported from: doid.owl
has_alternative_id: DOID:6342
has_alternative_id: DOID:9687
has cross-reference: ICD10CM:F34.1
has cross-reference: ICD10CM:F48.9
has cross-reference: MESH:D000275
has cross-reference: MESH:D003866
has cross-reference: MESH:D009497
has cross-reference: NCI:C34533
has cross-reference: NCI:C34848
has cross-reference: NCI:C35369
has cross-reference: SNOMEDCT_US_2020_03_01:154881002
has cross-reference: SNOMEDCT_US_2020_03_01:78667006
has cross-reference: SNOMEDCT_US_2020_03_01:87414006
has cross-reference: UMLS_CUI:C0011579
has cross-reference: UMLS_CUI:C0027932
has cross-reference: UMLS_CUI:C0282126
alternative_term: Neurotic depression reactive type
alternative_term: Neurotic depressive state
alternative_term: Psychoneurosis
alternative_term: depressive neurosis
alternative_term: neurosis
alternative_term: neurotic depression
alternative_term: reactive depression
has_obo_namespace: disease_ontology
id: DOID:4964
in subset: NCIthesaurus

Nelson syndrome
type: Class
subclass of: adrenal cortex disease
imported from: doid.owl
has cross-reference: GARD:7170
has cross-reference: ICD10CM:E24.1
has cross-reference: MESH:D009347
has cross-reference: NCI:C84917
has cross-reference: SNOMEDCT_US_2020_03_01:43019009
has cross-reference: UMLS_CUI:C0027577
alternative_term: Nelson's syndrome
has_obo_namespace: disease_ontology
id: DOID:4968
in subset: NCIthesaurus

prosopagnosia
type: Class
subclass of: agnosia
textual definition: An agnosia that results in the loss of the ability to consciously recognize familiar faces.
imported from: doid.owl
has cross-reference: ICD10CM:R48.3
has cross-reference: MESH:D020238
has cross-reference: NCI:C85031
has cross-reference: SNOMEDCT_US_2020_03_01:18358003
has cross-reference: UMLS_CUI:C0234512
has_obo_namespace: disease_ontology
id: DOID:4970
in subset: NCIthesaurus

myelofibrosis
type: Class
subclass of: myeloid neoplasm
textual definition: A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
imported from: doid.owl
has_alternative_id: DOID:5737
has cross-reference: GARD:8618
has cross-reference: ICD10CM:D47.4
has cross-reference: ICD10CM:D75.81
has cross-reference: ICD9CM:238.76
has cross-reference: ICD9CM:289.83
has cross-reference: MESH:D055728
has cross-reference: NCI:C2862
has cross-reference: NCI:C3248
has cross-reference: OMIM:254450
has cross-reference: SNOMEDCT_US_2020_03_01:128843003
has cross-reference: SNOMEDCT_US_2020_03_01:267572005
has cross-reference: UMLS_CUI:C0001815
has cross-reference: UMLS_CUI:C0026987
alternative_term: Agnogenic myeloid metaplasia
alternative_term: Aleukemic myelosis
alternative_term: Megakaryocytic myelosclerosis
alternative_term: bone Marrow Fibrosis
alternative_term: myelosclerosis
alternative_term: primary myelofibrosis
has_obo_namespace: disease_ontology
id: DOID:4971
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

myelodysplastic/myeloproliferative neoplasm
type: Class
subclass of: myeloid neoplasm
textual definition: A myeloid neoplasm that results_in the overproduction of white blood cells.
imported from: doid.owl
has_alternative_id: DOID:6470
has cross-reference: MESH:D054437
has cross-reference: NCI:C27262
has cross-reference: SNOMEDCT_US_2020_03_01:445738007
has cross-reference: UMLS_CUI:C1301355
alternative_term: Myeloproliferative/Myelodysplastic syndromes
alternative_term: myelodysplastic myeloproliferative cancer
has_obo_namespace: disease_ontology
has_related_synonym: myelodysplastic myeloproliferative disease
id: DOID:4972
in subset: NCIthesaurus

actinobacillosis
type: Class
subclass of: commensal bacterial infectious disease
subclass of: respiratory system disease
textual definition: A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.
imported from: doid.owl
has cross-reference: MESH:D000187
has cross-reference: SNOMEDCT_US_2020_03_01:16140007
has cross-reference: UMLS_CUI:C0001247
has_obo_namespace: disease_ontology
id: DOID:4974
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

elephantiasis
type: Class
subclass of: lymphedema
imported from: doid.owl
has cross-reference: MESH:D004604
has cross-reference: NCI:C34569
has cross-reference: SNOMEDCT_US_2020_03_01:155485008
has cross-reference: UMLS_CUI:C0013882
alternative_term: Elephantiasis
has_obo_namespace: disease_ontology
id: DOID:4976
in subset: NCIthesaurus

lymphedema
type: Class
subclass of: lymphatic system disease
imported from: doid.owl
has cross-reference: MESH:D008209
has cross-reference: NCI:C3207
has cross-reference: SNOMEDCT_US_2020_03_01:266334008
has cross-reference: UMLS_CUI:C0024236
alternative_term: Lymphatic edema
alternative_term: Lymphoedema
has_obo_namespace: disease_ontology
id: DOID:4977
in subset: NCIthesaurus

alcoholic pancreatitis
type: Class
subclass of: pancreatitis
imported from: doid.owl
has cross-reference: MESH:D019512
has cross-reference: SNOMEDCT_US_2020_03_01:445507008
has cross-reference: UMLS_CUI:C0376670
has_obo_namespace: disease_ontology
id: DOID:4988

pancreatitis
type: Class
subclass of: pancreas disease
imported from: doid.owl
has cross-reference: EFO:0000278
has cross-reference: ICD10CM:K85.9
has cross-reference: MESH:D010195
has cross-reference: NCI:C3306
has cross-reference: OMIM:167800
has cross-reference: SNOMEDCT_US_2020_03_01:393591004
has cross-reference: UMLS_CUI:C0030305
has_obo_namespace: disease_ontology
id: DOID:4989
in subset: NCIthesaurus

essential tremor
type: Class
subclass of: movement disease
textual definition: A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms.
imported from: doid.owl
has cross-reference: GARD:5910
has cross-reference: ICD10CM:G25.0
has cross-reference: MESH:D020329
has cross-reference: OMIM:PS190300
has cross-reference: ORDO:862
has cross-reference: SNOMEDCT_US_2020_03_01:192839001
has cross-reference: UMLS_CUI:C0270736
alternative_term: benign essential tremor
alternative_term: essential hereditary tremor
alternative_term: shaky hand syndrome
has_obo_namespace: disease_ontology
id: DOID:4990
in subset: DO rare slim
comment: Xref MGI.

optic nerve glioma
type: Class
subclass of: brain glioma
subclass of: optic nerve neoplasm
imported from: doid.owl
has cross-reference: GARD:4107
has cross-reference: MESH:D020339
has cross-reference: NCI:C4537
has cross-reference: SNOMEDCT_US_2020_03_01:254976006
has cross-reference: UMLS_CUI:C0346326
alternative_term: glioma of the optic nerve
has_obo_namespace: disease_ontology
id: DOID:4992
in subset: NCIthesaurus

Camurati-Engelmann disease
type: Class
subclass of: monogenic disease
subclass of: osteosclerosis
textual definition: An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone.
imported from: doid.owl
has cross-reference: GARD:1072
has cross-reference: ICD10CM:Q78.3
has cross-reference: MESH:D003966
has cross-reference: NCI:C84610
has cross-reference: OMIM:131300
has cross-reference: OMIM:606631
has cross-reference: SNOMEDCT_US_2020_03_01:34643004
has cross-reference: UMLS_CUI:C0011989
alternative_term: Diaphyseal dysplasia
alternative_term: Engelman's disease
alternative_term: progressive diaphyseal dysplasia
has_obo_namespace: disease_ontology
id: DOID:4997
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

thyroid gland disease
type: Class
subclass of: endocrine system disease
textual definition: An endocrine system disease that is located_in the thyroid.
imported from: doid.owl
has cross-reference: ICD10CM:E07.9
has cross-reference: ICD9CM:246.9
has cross-reference: MESH:D013959
has cross-reference: NCI:C26893
has cross-reference: SNOMEDCT_US_2020_03_01:14304000
has cross-reference: UMLS_CUI:C0040128
has_obo_namespace: disease_ontology
id: DOID:50
in subset: NCIthesaurus

fibrolamellar carcinoma
type: Class
subclass of: hepatocellular carcinoma
textual definition: A hepatocellular carcinoma characterized microscopically by laminated fibrous layers interspersed between the tumour cells. The polygonal, deeply eosinophilic tumor cells arise in non-cirrhotic livers.
imported from: doid.owl
has cross-reference: MESH:C537258
has cross-reference: NCI:C4131
has cross-reference: SNOMEDCT_US_2020_03_01:15619004
has cross-reference: UMLS_CUI:C0334287
alternative_term: Fibrolamellar hepatocellular carcinoma
alternative_term: Hepatocellular carcinoma, fibrolamellar
alternative_term: Oncocytic Hepatocellular tumor
has_obo_namespace: disease_ontology
id: DOID:5015
in subset: DO rare slim
in subset: NCIthesaurus

central nervous system mesenchymal non-meningothelial tumor
type: Class
subclass of: central nervous system cancer
textual definition: A central nervous system cancer that is characterized by mesenchymal tumors within the CNS that develops from meninges, has_material_basis_in abnormally proliferating cells derives_from mesoderm.
imported from: doid.owl
alternative_term: Non-meningothelial mesenchymal tumor
alternative_term: Non-meningothelial mesenchymal tumour
alternative_term: central nervous system mesenchymal non-meningothelial tumour
has_obo_namespace: disease_ontology
id: DOID:502

pineal gland cancer
type: Class
subclass of: endocrine gland cancer
textual definition: An endocrine gland located_in the pineal gland located in the brain.
imported from: doid.owl
has_alternative_id: DOID:1662
has_alternative_id: DOID:4859
has cross-reference: ICD10CM:C75.3
has cross-reference: ICD9CM:194.4
has cross-reference: MESH:D010871
has cross-reference: NCI:C3328
has cross-reference: NCI:C3573
has cross-reference: NCI:C6965
has cross-reference: SNOMEDCT_US_2020_03_01:127026004
has cross-reference: SNOMEDCT_US_2020_03_01:93962006
has cross-reference: UMLS_CUI:C0031941
has cross-reference: UMLS_CUI:C0153655
has cross-reference: UMLS_CUI:C1412004
alternative_term: Pinealoma
alternative_term: Pineocytic tumor
alternative_term: malignant Pineal Region tumor
alternative_term: malignant tumor of pineal gland
alternative_term: neoplasm of pineal gland
alternative_term: neoplasm of the Pineal Region
alternative_term: pineal body neoplasm
alternative_term: tumor of the pineal region
has_obo_namespace: disease_ontology
id: DOID:5032
in subset: NCIthesaurus

myoblastoma
type: Class
subclass of: muscle benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D009379
has cross-reference: NCI:C3252
has cross-reference: UMLS_CUI:C0027043
alternative_term: benign granular cell tumor
has_obo_namespace: disease_ontology
id: DOID:5039
in subset: NCIthesaurus

esophageal cancer
type: Class
subclass of: gastrointestinal system cancer
subclass of: esophageal disease
textual definition: A gastrointestinal system cancer that is located_in the esophagus.
imported from: doid.owl
has_alternative_id: DOID:10291
has_alternative_id: DOID:10292
has_alternative_id: DOID:10448
has_alternative_id: DOID:1102
has_alternative_id: DOID:1104
has cross-reference: GARD:6383
has cross-reference: ICD10CM:C15.3
has cross-reference: ICD10CM:C15.4
has cross-reference: ICD10CM:C15.5
has cross-reference: ICD9CM:150.2
has cross-reference: ICD9CM:150.3
has cross-reference: ICD9CM:150.4
has cross-reference: ICD9CM:150.5
has cross-reference: ICD9CM:150.8
has cross-reference: MESH:D004938
has cross-reference: NCI:C3028
has cross-reference: NCI:C3533
has cross-reference: NCI:C3534
has cross-reference: NCI:C3535
has cross-reference: NCI:C4764
has cross-reference: OMIM:133239
has cross-reference: SNOMEDCT_US_2020_03_01:126817006
has cross-reference: SNOMEDCT_US_2020_03_01:187729008
has cross-reference: SNOMEDCT_US_2020_03_01:93656003
has cross-reference: SNOMEDCT_US_2020_03_01:93877002
has cross-reference: SNOMEDCT_US_2020_03_01:93895004
has cross-reference: SNOMEDCT_US_2020_03_01:94119000
has cross-reference: UMLS_CUI:C0014859
has cross-reference: UMLS_CUI:C0153413
has cross-reference: UMLS_CUI:C0153414
has cross-reference: UMLS_CUI:C0153415
has cross-reference: UMLS_CUI:C0153416
has cross-reference: UMLS_CUI:C0496775
alternative_term: Ca lower third oesophagus
alternative_term: Ca middle third oesophagus
alternative_term: esophagus cancer
alternative_term: malignant neoplasm of distal third of esophagus
alternative_term: malignant neoplasm of lower third of oesophagus
alternative_term: malignant neoplasm of middle third of oesophagus
alternative_term: malignant neoplasm of proximal third of esophagus
alternative_term: malignant neoplasm of upper third esophagus
alternative_term: malignant tumor of Distal Third of esophagus
alternative_term: malignant tumor of Proximal Third of esophagus
alternative_term: malignant tumor of abdominal esophagus
alternative_term: malignant tumor of the middle Third of the esophagus
has_obo_namespace: disease_ontology
id: DOID:5041
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

malignant granular cell myoblastoma
type: Class
subclass of: skin cancer
imported from: doid.owl
has cross-reference: NCI:C4336
has cross-reference: SNOMEDCT_US_2020_03_01:404041003
has cross-reference: UMLS_CUI:C0334618
alternative_term: granular cell tumor, malignant
alternative_term: malignant granular cell neoplasm
alternative_term: malignant granular cell tumor
has_obo_namespace: disease_ontology
id: DOID:5042
in subset: NCIthesaurus

Ehrlich tumor carcinoma
type: Class
subclass of: breast carcinoma
imported from: doid.owl
has cross-reference: MESH:D002286
has cross-reference: UMLS_CUI:C0007125
alternative_term: Ehrlich tumour carcinoma
alternative_term: Ehrlich's tumor
alternative_term: Ehrlich's tumour
has_obo_namespace: disease_ontology
id: DOID:5050

melioidosis
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.
imported from: doid.owl
has_alternative_id: DOID:0050062
has_alternative_id: DOID:0050064
has cross-reference: GARD:9546
has cross-reference: ICD10CM:A24.9
has cross-reference: ICD9CM:025
has cross-reference: MESH:D008554
has cross-reference: NCI:C128336
has cross-reference: SNOMEDCT_US_2020_03_01:428111003
has cross-reference: UMLS_CUI:C0025229
alternative_term: Nightcliff gardener's disease
alternative_term: Pseudoglanders
alternative_term: Whitmore's disease
alternative_term: acute and fulminating melioidosis
alternative_term: subacute and chronic melioidosis
has_obo_namespace: disease_ontology
id: DOID:5052
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: zoonotic infectious disease

phencyclidine abuse
type: Class
subclass of: substance abuse
textual definition: A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences.
imported from: doid.owl
has cross-reference: MESH:D010623
has cross-reference: SNOMEDCT_US_2020_03_01:7071007
has cross-reference: UMLS_CUI:C0031391
alternative_term: PCP abuse
alternative_term: Phencyclidine abuse
has_obo_namespace: disease_ontology
id: DOID:5062

adjustment disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred.
imported from: doid.owl
has cross-reference: ICD9CM:309
has cross-reference: SNOMEDCT_US_2020_03_01:17226007
has cross-reference: UMLS_CUI:C0040701
alternative_term: adjustment disease
alternative_term: adjustment reaction
has_obo_namespace: disease_ontology
id: DOID:507

malignant ependymoma
type: Class
subclass of: carcinoma
subclass of: cerebral ventricle cancer
textual definition: A malignant glioma that is derived from ependymal cells, a type of glial cell, located_in ventricle lining within the central part of the brain.
imported from: doid.owl
has_alternative_id: DOID:0060107
has cross-reference: NCI:C6770
has cross-reference: UMLS_CUI:C1333407
alternative_term: Ependymal neoplasm
alternative_term: ependymal tumors
has_obo_namespace: disease_ontology
id: DOID:5074
in subset: NCIthesaurus

mixed glioma
type: Class
subclass of: malignant glioma
imported from: doid.owl
has cross-reference: MESH:D005910
has cross-reference: NCI:C3903
has cross-reference: SNOMEDCT_US_2020_03_01:443937008
has cross-reference: UMLS_CUI:C0259783
alternative_term: mixed Neuroglial tumor
alternative_term: mixed gliomas
has_obo_namespace: disease_ontology
id: DOID:5076
in subset: NCIthesaurus

subependymal giant cell astrocytoma
type: Class
subclass of: subependymal glioma
imported from: doid.owl
has cross-reference: GARD:10632
has cross-reference: MESH:D001254
has cross-reference: NCI:C3696
has cross-reference: SNOMEDCT_US_2020_03_01:449799008
has cross-reference: UMLS_CUI:C0205768
alternative_term: SEGA
alternative_term: Subependymal giant cell astrocytoma
has_obo_namespace: disease_ontology
id: DOID:5077
in subset: NCIthesaurus

ganglioglioma
type: Class
subclass of: cell type benign neoplasm
subclass of: central nervous system benign neoplasm
textual definition: A cell type benign neoplasm that has_material_basis_in glial-type cells.
imported from: doid.owl
has_alternative_id: DOID:5606
has_alternative_id: DOID:5607
has cross-reference: GARD:2430
has cross-reference: MESH:D018303
has cross-reference: NCI:C27362
has cross-reference: NCI:C27363
has cross-reference: NCI:C3788
has cross-reference: SNOMEDCT_US_2020_03_01:87191000119100
has cross-reference: UMLS_CUI:C0206716
has cross-reference: UMLS_CUI:C1332202
has cross-reference: UMLS_CUI:C1332969
alternative_term: CNS ganglioglioma
alternative_term: adult ganglioglioma
alternative_term: childhood ganglioglioma
has_obo_namespace: disease_ontology
id: DOID:5078
in subset: NCIthesaurus

liver cirrhosis
type: Class
subclass of: liver disease
imported from: doid.owl
has cross-reference: EFO:0001422
has cross-reference: ICD10CM:K74.60
has cross-reference: MESH:D008103
has cross-reference: NCI:C2951
has cross-reference: SNOMEDCT_US_2020_03_01:19943007
has cross-reference: UMLS_CUI:C0023890
alternative_term: Cirrhosis
alternative_term: cirrhosis of liver
has_obo_namespace: disease_ontology
id: DOID:5082
in subset: NCIthesaurus

thoracic cancer
type: Class
subclass of: organ system cancer
subclass of: thoracic disease
textual definition: An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.
imported from: doid.owl
has_alternative_id: DOID:3937
has cross-reference: ICD10CM:C76.1
has cross-reference: ICD9CM:195.1
has cross-reference: MESH:D013899
has cross-reference: NCI:C3406
has cross-reference: NCI:C3576
has cross-reference: SNOMEDCT_US_2020_03_01:188361007
has cross-reference: SNOMEDCT_US_2020_03_01:255058005
has cross-reference: UMLS_CUI:C0039981
has cross-reference: UMLS_CUI:C0153661
alternative_term: Thoracic tumor
alternative_term: thorax cancer
alternative_term: thorax neoplasm
alternative_term: tumor of thorax
has_obo_namespace: disease_ontology
id: DOID:5093
in subset: NCIthesaurus

middle ear disease
type: Class
subclass of: auditory system disease
imported from: doid.owl
has cross-reference: NCI:C27065
has cross-reference: SNOMEDCT_US_2020_03_01:155260002
has cross-reference: UMLS_CUI:C0271428
has_obo_namespace: disease_ontology
id: DOID:5100
in subset: NCIthesaurus

ear cancer
type: Class
subclass of: auditory system cancer
imported from: doid.owl
has cross-reference: MESH:D004428
has cross-reference: UMLS_CUI:C0751094
alternative_term: auricular cancer
alternative_term: malignant ear neoplasm
alternative_term: malignant tumor of ear
has_obo_namespace: disease_ontology
id: DOID:5101

copper deficiency myelopathy
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by deficiency of copper, causing spastic gait and ataxia, often with anemia and neutropenia, has_symptom imbalance and jerking movements, and has_material_basis_in copper deficiency possibly due to malabsorption or excess zinc ingestion.
imported from: doid.owl
has cross-reference: MESH:D013540
has cross-reference: SNOMEDCT_US_2020_03_01:78714004
has cross-reference: UMLS_CUI:C0038981
alternative_term: human swayback
has_obo_namespace: disease_ontology
id: DOID:5112

nutritional deficiency disease
type: Class
subclass of: nutrition disease
textual definition: A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content.
imported from: doid.owl
has cross-reference: MESH:D003677
has cross-reference: UMLS_CUI:C0011156
has_obo_namespace: disease_ontology
id: DOID:5113

leiomyoma cutis
type: Class
subclass of: dermis tumor
imported from: doid.owl
has cross-reference: NCI:C4482
has cross-reference: SNOMEDCT_US_2020_03_01:254767008
has cross-reference: UMLS_CUI:C0346064
alternative_term: Cutaneous leiomyoma
alternative_term: leiomyoma of the skin
has_obo_namespace: disease_ontology
id: DOID:5132
in subset: NCIthesaurus

leiomyomatosis
type: Class
subclass of: leiomyoma
textual definition: A leiomyoma that is multiple and diffuse.
imported from: doid.owl
has cross-reference: MESH:D018231
has cross-reference: NCI:C3748
has cross-reference: SNOMEDCT_US_2020_03_01:75210008
has cross-reference: UMLS_CUI:C0206654
has_obo_namespace: disease_ontology
id: DOID:5138
in subset: NCIthesaurus

vulvar leiomyoma
type: Class
subclass of: vulvar benign neoplasm
textual definition: A vulvar benign neoplasm that is located_in smooth muscle cells.
imported from: doid.owl
has cross-reference: NCI:C40326
has cross-reference: UMLS_CUI:C1520087
has_obo_namespace: disease_ontology
id: DOID:5142
in subset: NCIthesaurus

borna disease
type: Class
subclass of: central nervous system disease
subclass of: DOID 934
textual definition: A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.
imported from: doid.owl
has cross-reference: MESH:D001890
has cross-reference: SNOMEDCT_US_2020_03_01:76851008
has cross-reference: UMLS_CUI:C0006023
alternative_term: Enzootic encephalomyelitis
has_obo_namespace: disease_ontology
id: DOID:5154
in subset: zoonotic infectious disease

pleural cancer
type: Class
subclass of: connective tissue cancer
textual definition: A connective tissue cancer that located_in the pleura.
imported from: doid.owl
has_alternative_id: DOID:9917
has cross-reference: ICD10CM:C38.4
has cross-reference: ICD9CM:163
has cross-reference: MESH:D010997
has cross-reference: NCI:C3332
has cross-reference: NCI:C3547
has cross-reference: SNOMEDCT_US_2020_03_01:126719004
has cross-reference: SNOMEDCT_US_2020_03_01:363433009
has cross-reference: UMLS_CUI:C0032229
has cross-reference: UMLS_CUI:C0153494
alternative_term: Pleural tumor
alternative_term: neoplasm of pleura
has_obo_namespace: disease_ontology
id: DOID:5158
in subset: NCIthesaurus

arteriosclerosis obliterans
type: Class
subclass of: arteriosclerosis
imported from: doid.owl
has cross-reference: MESH:D001162
has cross-reference: SNOMEDCT_US_2020_03_01:60625000
has cross-reference: UMLS_CUI:C0003851
alternative_term: Arteriosclerosis obliterans
has_obo_namespace: disease_ontology
id: DOID:5160

arteriolosclerosis
type: Class
subclass of: arteriosclerosis
textual definition: An arteriosclerosis that is characterized by thickening of the wall of the small arteries and arterioles, caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy, and results in lumen narrowing and tissue ischemia.
imported from: doid.owl
has cross-reference: ICD10CM:I70
has cross-reference: MESH:D050379
has cross-reference: NCI:C35543
has cross-reference: SNOMEDCT_US_2020_03_01:17941002
has cross-reference: UMLS_CUI:C0878486
alternative_term: Arteriolosclerosis
has_obo_namespace: disease_ontology
id: DOID:5162
in subset: NCIthesaurus

endometrial stromal tumor
type: Class
subclass of: endometrial cancer
imported from: doid.owl
has cross-reference: MESH:D036821
has cross-reference: SNOMEDCT_US_2020_03_01:68738004
has cross-reference: UMLS_CUI:C0334695
alternative_term: endometrial Stromal neoplasm
has_obo_namespace: disease_ontology
id: DOID:5166

hereditary Wilms' tumor
type: Class
subclass of: nephroblastoma
textual definition: A nephroblastoma that results_in either bilateral disease or a family history of Wilms' tumour.
imported from: doid.owl
has cross-reference: NCI:C8496
has cross-reference: UMLS_CUI:C0677779
alternative_term: Hereditary Wilms tumor
alternative_term: Hereditary Wilms tumour
alternative_term: WT1
alternative_term: hereditary Wilms' tumour
has_obo_namespace: disease_ontology
has_related_synonym: hereditary Wilms' tumor
id: DOID:5183
in subset: NCIthesaurus

aortitis
type: Class
subclass of: aortic disease
imported from: doid.owl
has cross-reference: ICD10CM:I77.6
has cross-reference: MESH:D001025
has cross-reference: NCI:C97085
has cross-reference: SNOMEDCT_US_2020_03_01:195368003
has cross-reference: UMLS_CUI:C0003509
has_obo_namespace: disease_ontology
id: DOID:519
in subset: NCIthesaurus

ureteral obstruction
type: Class
subclass of: ureteral disease
subclass of: urinary tract obstruction
imported from: doid.owl
has cross-reference: ICD9CM:593.4
has cross-reference: SNOMEDCT_US_2020_03_01:197807001
has cross-reference: UMLS_CUI:C0029866
has_obo_namespace: disease_ontology
id: DOID:5199

aortic disease
type: Class
subclass of: artery disease
textual definition: An artery disease that is characterized by degeneration of the cells composing the aortic wall.
imported from: doid.owl
has cross-reference: MESH:D001018
has cross-reference: NCI:C101253
has cross-reference: SNOMEDCT_US_2020_03_01:47040006
has cross-reference: UMLS_CUI:C0003493
alternative_term: aortic disorder
alternative_term: disorder of the aorta
has_obo_namespace: disease_ontology
id: DOID:520
in subset: NCIthesaurus

urinary tract obstruction
type: Class
subclass of: urinary system disease
imported from: doid.owl
has cross-reference: ICD10CM:N13.9
has cross-reference: ICD9CM:599.6
has cross-reference: NCI:C79805
has cross-reference: SNOMEDCT_US_2020_03_01:7163005
has cross-reference: UMLS_CUI:C0178879
alternative_term: Obstructive Uropathy
alternative_term: urinary obstruction
has_obo_namespace: disease_ontology
id: DOID:5200
in subset: NCIthesaurus

fructose-1,6-bisphosphatase deficiency
type: Class
subclass of: carbohydrate metabolic disorder
textual definition: A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.
imported from: doid.owl
has cross-reference: GARD:2400
has cross-reference: ICD10CM:E74.19
has cross-reference: MESH:D015319
has cross-reference: NCI:C128119
has cross-reference: OMIM:229700
has cross-reference: SNOMEDCT_US_2020_03_01:28183005
has cross-reference: UMLS_CUI:C0016756
alternative_term: fructose 1 phosphate aldolase deficiency
alternative_term: fructose-1,6-diphosphatase deficiency
has_obo_namespace: disease_ontology
id: DOID:5204
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

monodermal teratoma
type: Class
subclass of: ovarian germ cell teratoma
textual definition: An ovarian germ cell teratoma that has_material_basis_in a tissue type from one germ cell layer (ectoderm, mesoderm or endoderm).
imported from: doid.owl
has cross-reference: NCI:C7286
has cross-reference: SNOMEDCT_US_2020_03_01:399632009
has cross-reference: UMLS_CUI:C1302569
alternative_term: Ovarian Monodermal teratoma
has_obo_namespace: disease_ontology
id: DOID:5207
in subset: NCIthesaurus

congenital disorder of glycosylation
type: Class
subclass of: physical disorder
subclass of: carbohydrate metabolic disorder
textual definition: A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids.
imported from: doid.owl
has cross-reference: GARD:10307
has cross-reference: MESH:D018981
has cross-reference: NCI:C84615
has cross-reference: OMIM:PS212065
has cross-reference: ORDO:137
has cross-reference: SNOMEDCT_US_2020_03_01:238049009
has cross-reference: UMLS_CUI:C0282577
alternative_term: carbohydrate-deficient glycoprotein syndrome
has_obo_namespace: disease_ontology
id: DOID:5212
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

chronic inflammatory demyelinating polyradiculoneuropathy
type: Class
subclass of: autoimmune disease of peripheral nervous system
textual definition: An autoimmune disease of peripheral nervous system that is characterized by inflammation of nerve roots and peripheral nerves and destruction of the fatty protective covering (myelin sheath) over the nerves. This affects how fast the nerve signals are transmitted and leads to loss of nerve fibers.
imported from: doid.owl
has cross-reference: GARD:6102
has cross-reference: ICD10CM:G61.81
has cross-reference: ICD9CM:357.81
has cross-reference: MESH:D020277
has cross-reference: NCI:C84636
has cross-reference: SNOMEDCT_US_2020_03_01:128209004
has cross-reference: UMLS_CUI:C0393819
has_obo_namespace: disease_ontology
id: DOID:5213
in subset: NCIthesaurus

demyelinating polyneuropathy
type: Class
subclass of: polyneuropathy
imported from: doid.owl
has cross-reference: NCI:C27062
has cross-reference: SNOMEDCT_US_2020_03_01:23414001
has cross-reference: UMLS_CUI:C0270922
alternative_term: peripheral demyelinating neuropathy
has_obo_namespace: disease_ontology
id: DOID:5214
in subset: NCIthesaurus

chronic polyneuropathy
type: Class
subclass of: polyneuropathy
imported from: doid.owl
has cross-reference: NCI:C36071
has cross-reference: UMLS_CUI:C1167650
has_obo_namespace: disease_ontology
id: DOID:5221
in subset: NCIthesaurus

acute necrotizing encephalitis
type: Class
subclass of: DOID 9588
imported from: doid.owl
has cross-reference: MESH:D004684
has cross-reference: NCI:C35383
has cross-reference: SNOMEDCT_US_2020_03_01:111897007
has cross-reference: UMLS_CUI:C0338418
has_obo_namespace: disease_ontology
id: DOID:5222
in subset: NCIthesaurus

infertility
type: Class
subclass of: reproductive system disease
imported from: doid.owl
has cross-reference: MESH:D007246
has cross-reference: NCI:C3836
has cross-reference: SNOMEDCT_US_2020_03_01:8619003
has cross-reference: UMLS_CUI:C0021359
has_obo_namespace: disease_ontology
id: DOID:5223
in subset: NCIthesaurus

hepatoerythropoietic porphyria
type: Class
subclass of: acute porphyria
imported from: doid.owl
has cross-reference: GARD:6169
has cross-reference: MESH:D017121
has cross-reference: NCI:C84754
has cross-reference: ORDO:95159
has cross-reference: SNOMEDCT_US_2020_03_01:111386004
has cross-reference: UMLS_CUI:C0162569
has_obo_namespace: disease_ontology
id: DOID:5230
in subset: NCIthesaurus

benign perivascular tumor
type: Class
subclass of: cardiovascular organ benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C6529
has cross-reference: UMLS_CUI:C1332532
has_obo_namespace: disease_ontology
id: DOID:5238
in subset: NCIthesaurus

hemangioblastoma
type: Class
subclass of: hemangioma
imported from: doid.owl
has cross-reference: GARD:8232
has cross-reference: GARD:8522
has cross-reference: MESH:D018325
has cross-reference: NCI:C3801
has cross-reference: SNOMEDCT_US_2020_03_01:81201000
has cross-reference: UMLS_CUI:C0206734
alternative_term: Capillary Hemangioblastoma
has_obo_namespace: disease_ontology
id: DOID:5241
in subset: NCIthesaurus

human immunodeficiency virus infectious disease
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.
imported from: doid.owl
has cross-reference: ICD10CM:B20
has cross-reference: ICD9CM:042-042.99
has cross-reference: MESH:D015658
has cross-reference: NCI:C3108
has cross-reference: SNOMEDCT_US_2020_03_01:86406008
has cross-reference: UMLS_CUI:C0019693
alternative_term: HIV infection
has_obo_namespace: disease_ontology
id: DOID:526
in subset: NCIthesaurus
in subset: zoonotic infectious disease

small intestinal sarcoma
type: Class
subclass of: small intestine cancer
textual definition: A sarcoma and malignant tumor of small intestine that is located_in the small intestine.
imported from: doid.owl
has cross-reference: NCI:C5335
has cross-reference: UMLS_CUI:C1336007
alternative_term: sarcoma of the Small Intestine
has_obo_namespace: disease_ontology
id: DOID:5272
in subset: NCIthesaurus

hydrarthrosis
type: Class
subclass of: arthropathy
imported from: doid.owl
has cross-reference: ICD9CM:719.08
has cross-reference: SNOMEDCT_US_2020_03_01:156579009
has cross-reference: UMLS_CUI:C0158157
has_obo_namespace: disease_ontology
id: DOID:528

prostate leiomyosarcoma
type: Class
subclass of: prostate sarcoma
textual definition: A prostate sarcoma that is located_in the prostate.
imported from: doid.owl
has cross-reference: NCI:C5526
has cross-reference: UMLS_CUI:C1335511
alternative_term: leiomyosarcoma of the prostate
has_obo_namespace: disease_ontology
id: DOID:5282
in subset: NCIthesaurus

retroperitoneal leiomyosarcoma
type: Class
subclass of: retroperitoneal sarcoma
imported from: doid.owl
has cross-reference: NCI:C27904
has_obo_namespace: disease_ontology
id: DOID:5284
in subset: NCIthesaurus

breast leiomyosarcoma
type: Class
subclass of: breast sarcoma
textual definition: A breast sarcoma that arises from smooth muscle cells.
imported from: doid.owl
has cross-reference: NCI:C5186
has cross-reference: UMLS_CUI:C1332631
alternative_term: leiomyosarcoma of the breast
has_obo_namespace: disease_ontology
id: DOID:5285
in subset: NCIthesaurus

kidney leiomyosarcoma
type: Class
subclass of: kidney sarcoma
textual definition: A leiomyosarcoma and sarcoma of kidney that is located_in the kidney.
imported from: doid.owl
has cross-reference: NCI:C6183
has cross-reference: UMLS_CUI:C1335743
alternative_term: leiomyosarcoma of kidney
has_obo_namespace: disease_ontology
id: DOID:5287
in subset: NCIthesaurus

blepharospasm
type: Class
subclass of: focal dystonia
textual definition: A focal dystonia that is characterized by the involuntary, forcible contraction of the muscles controlling eye blinks.
imported from: doid.owl
has cross-reference: GARD:5909
has cross-reference: ICD10CM:G24.5
has cross-reference: ICD9CM:333.81
has cross-reference: MESH:D001764
has cross-reference: NCI:C118723
has cross-reference: SNOMEDCT_US_2020_03_01:155009007
has cross-reference: UMLS_CUI:C0005747
has_obo_namespace: disease_ontology
id: DOID:529
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

intestinal disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the intestine.
imported from: doid.owl
has_alternative_id: DOID:10759
has_alternative_id: DOID:11222
has_alternative_id: DOID:11789
has_alternative_id: DOID:8531
has_alternative_id: DOID:8558
has_alternative_id: DOID:8591
has cross-reference: ICD10CM:K63.9
has cross-reference: ICD9CM:569.9
has cross-reference: MESH:D007410
has cross-reference: NCI:C26801
has cross-reference: SNOMEDCT_US_2020_03_01:266483008
has cross-reference: UMLS_CUI:C0021831
has_obo_namespace: disease_ontology
id: DOID:5295
in subset: NCIthesaurus

pituitary gland disease
type: Class
subclass of: endocrine system disease
textual definition: An endocrine system disease that is located_in the pituitary gland.
imported from: doid.owl
has_alternative_id: DOID:2445
has_alternative_id: DOID:8713
has_alternative_id: DOID:8714
has cross-reference: ICD9CM:253.1
has cross-reference: UMLS_CUI:C0029493
alternative_term: pituitary disease
has_obo_namespace: disease_ontology
id: DOID:53

eyelid disease
type: Class
subclass of: skin disease
textual definition: An adnexa disease that is located_in the eyelid.
imported from: doid.owl
has cross-reference: ICD10CM:H02.9
has cross-reference: ICD9CM:374.9
has cross-reference: MESH:D005141
has cross-reference: NCI:C26768
has cross-reference: SNOMEDCT_US_2020_03_01:60113004
has cross-reference: UMLS_CUI:C0015423
has_obo_namespace: disease_ontology
id: DOID:530
in subset: NCIthesaurus

ovarian clear cell adenocarcinoma
type: Class
subclass of: ovary adenocarcinoma
textual definition: A ovarian adenocarcinoma that derives_from epithelial cells which have clear cytoplasm.
imported from: doid.owl
has cross-reference: NCI:C40078
has cross-reference: SNOMEDCT_US_2020_03_01:763131005
has cross-reference: UMLS_CUI:C1518693
has_obo_namespace: disease_ontology
id: DOID:5304
in subset: NCIthesaurus

epithelial-myoepithelial carcinoma
type: Class
subclass of: DOID 8850
imported from: doid.owl
has cross-reference: NCI:C4199
has cross-reference: SNOMEDCT_US_2020_03_01:189722008
has cross-reference: UMLS_CUI:C0334392
has_obo_namespace: disease_ontology
id: DOID:5309
in subset: NCIthesaurus

Roberts syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by tetraphocomelia, craniofacial anomalies, growth retardation, intellectual disability, and cardiac and renal abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in ESCO2 on chromosome 8p21.1.
imported from: doid.owl
has_alternative_id: DOID:0050536
has cross-reference: GARD:7387
has cross-reference: MESH:C535687
has cross-reference: NCI:C4681
has cross-reference: OMIM:268300
has cross-reference: OMIM:269000
has cross-reference: ORDO:3103
has cross-reference: SNOMEDCT_US_2020_03_01:48718006
has cross-reference: UMLS_CUI:C0392475
alternative_term: LONG BONE DEFICIENCIES ASSOCIATED WITH CLEFT LIP-PALATE
alternative_term: RBS
alternative_term: SC phocomelia syndrome
has_obo_namespace: disease_ontology
id: DOID:5325
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

retinal detachment
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: ICD10CM:H33.2
has cross-reference: ICD9CM:361.9
has cross-reference: MESH:D012163
has cross-reference: NCI:C26874
has cross-reference: SNOMEDCT_US_2020_03_01:155103005
has cross-reference: UMLS_CUI:C0035305
has_obo_namespace: disease_ontology
id: DOID:5327
in subset: NCIthesaurus

thymus gland disease
type: Class
subclass of: lymphatic system disease
imported from: doid.owl
has_alternative_id: DOID:11024
has cross-reference: ICD10CM:E32
has cross-reference: ICD9CM:254
has cross-reference: NCI:C26962
has cross-reference: SNOMEDCT_US_2020_03_01:20673009
has cross-reference: UMLS_CUI:C0154199
alternative_term: disease of thymus gland
has_obo_namespace: disease_ontology
id: DOID:533
in subset: NCIthesaurus

dental pulp disease
type: Class
subclass of: tooth disease
subclass of: connective tissue disease
imported from: doid.owl
has cross-reference: MESH:D003788
has cross-reference: NCI:C34530
has cross-reference: SNOMEDCT_US_2020_03_01:57203004
has cross-reference: UMLS_CUI:C0011405
alternative_term: Dental pulp disorder
alternative_term: disorder of pulp of tooth
alternative_term: pulp disorder
has_obo_namespace: disease_ontology
id: DOID:5330
in subset: NCIthesaurus

testicular granulosa cell tumor
type: Class
subclass of: granulosa cell tumor
imported from: doid.owl
has cross-reference: NCI:C6357
has cross-reference: UMLS_CUI:C1336709
alternative_term: Granulosa cell tumor of testis
alternative_term: Granulosa cell tumour of testis
alternative_term: testicular granulosa cell tumour
has_obo_namespace: disease_ontology
id: DOID:5331
in subset: NCIthesaurus

epulis
type: Class
subclass of: gingival overgrowth
imported from: doid.owl
has cross-reference: MESH:D005882
has cross-reference: NCI:C3948
has cross-reference: SNOMEDCT_US_2020_03_01:71708001
has cross-reference: UMLS_CUI:C0266919
alternative_term: Gingival polyp
alternative_term: epulides
alternative_term: polyp of Gum
has_obo_namespace: disease_ontology
id: DOID:5337
in subset: NCIthesaurus

sleep disorder
type: Class
subclass of: disease of mental health
textual definition: A disease of mental health that involves disruption of sleep patterns.
imported from: doid.owl
has_alternative_id: DOID:9028
has cross-reference: ICD9CM:307.4
has cross-reference: UMLS_CUI:C0154564
alternative_term: Non-organic sleep disorder
has_obo_namespace: disease_ontology
id: DOID:535
in subset: DO FlyBase slim

colonic disease
type: Class
subclass of: intestinal disease
textual definition: A intestinal disease located in the colon.
imported from: doid.owl
has_alternative_id: DOID:10758
has cross-reference: MESH:D003108
has cross-reference: SNOMEDCT_US_2020_03_01:128524007
has cross-reference: UMLS_CUI:C0009373
alternative_term: colon disorder
has_obo_namespace: disease_ontology
id: DOID:5353

myxoid liposarcoma
type: Class
subclass of: liposarcoma
textual definition: A liposarcoma that is characterized by the presence of a hypocellular spindle cell proliferation set in a myxoid background and has_material_basis_in chromosomal translocations.
imported from: doid.owl
has cross-reference: GARD:7157
has cross-reference: MESH:D018208
has cross-reference: OMIM:613488
has cross-reference: ORDO:99967
has cross-reference: SNOMEDCT_US_2020_03_01:404069006
has cross-reference: UMLS_CUI:C0206634
alternative_term: Myxoid/round cell liposarcoma
has_obo_namespace: disease_ontology
id: DOID:5363
comment: OMIM mapping confirmed by DO. [SN].

pulmonary coin lesion
type: Class
subclass of: lung benign neoplasm
imported from: doid.owl
has cross-reference: ICD10CM:R91.1
has cross-reference: MESH:D003074
has cross-reference: SNOMEDCT_US_2020_03_01:308689002
has cross-reference: UMLS_CUI:C0009250
alternative_term: Coin lesion lung
alternative_term: Coin lesion of lung
has_obo_namespace: disease_ontology
id: DOID:5364

pilomatrixoma
type: Class
subclass of: hair follicle neoplasm
imported from: doid.owl
has_alternative_id: DOID:5377
has cross-reference: GARD:9452
has cross-reference: MESH:D018296
has cross-reference: NCI:C7368
has cross-reference: OMIM:132600
has cross-reference: SNOMEDCT_US_2020_03_01:274901004
has cross-reference: UMLS_CUI:C0206711
alternative_term: Pilomatricoma
alternative_term: benign pilomatricoma
has_obo_namespace: disease_ontology
id: DOID:5374
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

hair follicle neoplasm
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C7367
has cross-reference: SNOMEDCT_US_2020_03_01:44155009
has cross-reference: UMLS_CUI:C0859920
alternative_term: Hair Matrix neoplasm
alternative_term: Hair matrix tumour
has_obo_namespace: disease_ontology
id: DOID:5375
in subset: NCIthesaurus

skin pilomatrix carcinoma
type: Class
subclass of: skin carcinoma
imported from: doid.owl
has cross-reference: NCI:C4114
has cross-reference: SNOMEDCT_US_2020_03_01:307610008
has cross-reference: UMLS_CUI:C0585475
alternative_term: Pilomatricoma, malignant
alternative_term: Pilomatrix carcinoma of skin
alternative_term: malignant Pilomatricoma
has_obo_namespace: disease_ontology
has_related_synonym: pilomatrix carcinoma of skin
id: DOID:5376
in subset: NCIthesaurus

hemoglobin E disease
type: Class
subclass of: hemoglobinopathy
imported from: doid.owl
has cross-reference: GARD:2641
has cross-reference: ICD10CM:D58.2
has cross-reference: NCI:C35287
has cross-reference: SNOMEDCT_US_2020_03_01:25065001
has cross-reference: UMLS_CUI:C0238159
alternative_term: Hb-E disease
alternative_term: Hemoglobin E disease
has_obo_namespace: disease_ontology
id: DOID:5379
in subset: NCIthesaurus

bile duct adenoma
type: Class
subclass of: biliary tract benign neoplasm
subclass of: bile duct disease
subclass of: adenoma
textual definition: A biliary tract benign neoplasm that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma.
imported from: doid.owl
has cross-reference: MESH:D002759
has cross-reference: NCI:C2942
has cross-reference: SNOMEDCT_US_2020_03_01:39471001
has cross-reference: UMLS_CUI:C0008309
alternative_term: Cholangioadenoma
has_obo_namespace: disease_ontology
id: DOID:5381
in subset: NCIthesaurus

lung adenoma
type: Class
subclass of: lung benign neoplasm
subclass of: adenoma
textual definition: A lung benign neoplasm that derives_from glandular epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C4455
has cross-reference: SNOMEDCT_US_2020_03_01:254642004
has cross-reference: UMLS_CUI:C0345964
alternative_term: adenoma of lung
alternative_term: pulmonary adenoma
has_obo_namespace: disease_ontology
id: DOID:5386
in subset: NCIthesaurus

middle ear adenoma
type: Class
subclass of: cell type benign neoplasm
subclass of: auditory system benign neoplasm
subclass of: middle ear disease
textual definition: A sensory organ benign neoplasm that is located_in the middle ear.
imported from: doid.owl
has cross-reference: NCI:C6834
has cross-reference: SNOMEDCT_US_2020_03_01:734078009
has cross-reference: UMLS_CUI:C1334759
alternative_term: adenoma of the middle ear
has_obo_namespace: disease_ontology
has_related_synonym: adenoma of middle ear
id: DOID:5387
in subset: NCIthesaurus

oxyphilic adenoma
type: Class
subclass of: endocrine organ benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D018249
has cross-reference: NCI:C3759
has cross-reference: SNOMEDCT_US_2020_03_01:89439007
has cross-reference: UMLS_CUI:C1510502
alternative_term: Follicular adenoma, oxyphilic cell
alternative_term: Oncocytoma
has_obo_namespace: disease_ontology
id: DOID:5389
in subset: NCIthesaurus

ophthalmoplegia
type: Class
subclass of: ocular motility disease
imported from: doid.owl
has_alternative_id: DOID:10868
has cross-reference: ICD9CM:378.56
has cross-reference: MESH:D009886
has cross-reference: NCI:C79697
has cross-reference: SNOMEDCT_US_2020_03_01:16110005
has cross-reference: SNOMEDCT_US_2020_03_01:78097002
has cross-reference: UMLS_CUI:C0029089
has cross-reference: UMLS_CUI:C0155338
alternative_term: Total ophthalmoplegia
alternative_term: oculomotor paralysis
has_obo_namespace: disease_ontology
id: DOID:539
in subset: NCIthesaurus

brain angioma
type: Class
subclass of: central nervous system benign neoplasm
subclass of: hemangioma
subclass of: cerebrovascular disease
imported from: doid.owl
has cross-reference: NCI:C7739
has cross-reference: UMLS_CUI:C0238814
has_obo_namespace: disease_ontology
id: DOID:5393
in subset: NCIthesaurus

functioning pituitary adenoma
type: Class
subclass of: pituitary adenoma
imported from: doid.owl
has cross-reference: NCI:C8388
has cross-reference: UMLS_CUI:C0854486
alternative_term: Secretory adenoma of the Pituitary gland
has_obo_namespace: disease_ontology
id: DOID:5395
in subset: NCIthesaurus

lipoadenoma
type: Class
subclass of: adenoma
textual definition: An adenoma that is composed_of epithelial cells admixed with adipose tissue cells.
imported from: doid.owl
has cross-reference: NCI:C4159
has cross-reference: SNOMEDCT_US_2020_03_01:22024005
has cross-reference: UMLS_CUI:C0334325
has_obo_namespace: disease_ontology
id: DOID:5398
in subset: NCIthesaurus

strabismus
type: Class
subclass of: ocular motility disease
subclass of: DOID 9834
textual definition: A hyperopia that is characterized by eyes that do not properly align with each other when looking at an object.
imported from: doid.owl
has cross-reference: ICD10CM:H50.8
has cross-reference: ICD9CM:378.7
has cross-reference: SNOMEDCT_US_2020_03_01:194125000
has cross-reference: UMLS_CUI:C0029831
has_obo_namespace: disease_ontology
id: DOID:540

microcystic adenoma
type: Class
subclass of: cell type benign neoplasm
subclass of: pancreatic cystadenoma
textual definition: A pancreatic cystadenoma that is characterized by innumerable small cysts lined by bland clear cells.
imported from: doid.owl
has cross-reference: MESH:D000236
has cross-reference: NCI:C3685
has cross-reference: SNOMEDCT_US_2020_03_01:189580001
has cross-reference: UMLS_CUI:C0205648
alternative_term: Microcystic adenoma
has_obo_namespace: disease_ontology
id: DOID:5403
in subset: NCIthesaurus

Paget's disease of bone
type: Class
subclass of: spinal disease
subclass of: hyperostosis
textual definition: A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.
imported from: doid.owl
has cross-reference: EFO:0004261
has cross-reference: GARD:8615
has cross-reference: ICD10CM:M88
has cross-reference: MESH:D010001
has cross-reference: NCI:C3292
has cross-reference: OMIM:167250
has cross-reference: OMIM:602080
has cross-reference: OMIM:606263
has cross-reference: ORDO:280110
has cross-reference: SNOMEDCT_US_2020_03_01:2089002
has cross-reference: UMLS_CUI:C0029401
alternative_term: Paget disease of bone
alternative_term: Paget's bone disease
alternative_term: osseous Paget's disease
alternative_term: osteitis deformans
has_obo_namespace: disease_ontology
has_related_synonym: Familial Paget's disease of bone
id: DOID:5408
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. MESH:C538098 added from NeuroDevNet [WAK].

lung small cell carcinoma
type: Class
subclass of: lung carcinoma
textual definition: A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the lung.
imported from: doid.owl
has_alternative_id: DOID:0050875
has cross-reference: KEGG:05222
has cross-reference: MESH:D055752
has cross-reference: NCI:C4917
has cross-reference: OMIM:182280
has cross-reference: SNOMEDCT_US_2020_03_01:254632001
has cross-reference: UMLS_CUI:C0149925
has_obo_namespace: disease_ontology
id: DOID:5409
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

schizoaffective disorder
type: Class
subclass of: psychotic disorder
textual definition: A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.
imported from: doid.owl
has cross-reference: ICD10CM:F25
has cross-reference: ICD9CM:295.7
has cross-reference: MESH:D011618
has cross-reference: NCI:C94378
has cross-reference: SNOMEDCT_US_2020_03_01:231490005
has cross-reference: UMLS_CUI:C0036337
has_obo_namespace: disease_ontology
id: DOID:5418
in subset: NCIthesaurus

schizophrenia
type: Class
subclass of: psychotic disorder
textual definition: A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.
imported from: doid.owl
has_alternative_id: DOID:14734
has cross-reference: EFO:0000692
has cross-reference: ICD10CM:F20
has cross-reference: ICD9CM:295
has cross-reference: MESH:D012559
has cross-reference: NCI:C3362
has cross-reference: OMIM:181500
has cross-reference: SNOMEDCT_US_2020_03_01:58214004
has cross-reference: UMLS_CUI:C0036341
alternative_term: schizophrenia-1
has_obo_namespace: disease_ontology
id: DOID:5419
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

ovarian hyperstimulation syndrome
type: Class
subclass of: ovarian disease
textual definition: An ovarian disease that is characterized by cystic enlargement of the ovaries and a fluid shift from the intravascular to the third space and has_symptom abdominal pain, has_symptom nausea and has_symptom vomiting. This disease is an iatrogenic complication of assisted reproduction technology.
imported from: doid.owl
has cross-reference: MESH:D016471
has cross-reference: OMIM:608115
has cross-reference: SNOMEDCT_US_2020_03_01:129635004
has cross-reference: UMLS_CUI:C0085083
alternative_term: secondary Meig's syndrome
has_obo_namespace: disease_ontology
id: DOID:5425
comment: OMIM mapping confirmed by DO. [SN].

premature ovarian failure
type: Class
subclass of: ovarian disease
textual definition: An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40.
imported from: doid.owl
has cross-reference: ICD10CM:E28.3
has cross-reference: MESH:D016649
has cross-reference: NCI:C113352
has cross-reference: OMIM:300511
has cross-reference: OMIM:300604
has cross-reference: OMIM:311360
has cross-reference: OMIM:608996
has cross-reference: OMIM:611548
has cross-reference: OMIM:612310
has cross-reference: OMIM:612964
has cross-reference: OMIM:615723
has cross-reference: OMIM:615724
has cross-reference: ORDO:619
has cross-reference: SNOMEDCT_US_2020_03_01:237788002
has cross-reference: UMLS_CUI:C0085215
alternative_term: hypergonadotropic hypogonadism
alternative_term: premature menopause
alternative_term: premature ovarian insufficiency
alternative_term: primary ovarian insufficiency
has_obo_namespace: disease_ontology
id: DOID:5426
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

dystonia
type: Class
subclass of: movement disease
imported from: doid.owl
has_alternative_id: DOID:544
has cross-reference: ICD10CM:G24
has cross-reference: MESH:D004421
has cross-reference: MESH:D020821
has cross-reference: NCI:C34563
has cross-reference: OMIM:PS128100
has cross-reference: SNOMEDCT_US_2020_03_01:15802004
has cross-reference: SNOMEDCT_US_2020_03_01:250068003
has cross-reference: UMLS_CUI:C0013421
has cross-reference: UMLS_CUI:C0393593
alternative_term: dystonic disease
has_obo_namespace: disease_ontology
id: DOID:543
in subset: DO FlyBase slim
in subset: NCIthesaurus

bladder papillary transitional cell neoplasm
type: Class
subclass of: urinary tract papillary transitional cell benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C39857
has cross-reference: UMLS_CUI:C1511197
alternative_term: urinary bladder Papillary Urothelial neoplasm
has_obo_namespace: disease_ontology
id: DOID:5432
in subset: NCIthesaurus

urinary tract papillary transitional cell benign neoplasm
type: Class
subclass of: papilloma
subclass of: urinary system benign neoplasm
imported from: doid.owl
has_alternative_id: DOID:6120
has cross-reference: NCI:C27883
has cross-reference: NCI:C6192
has cross-reference: SNOMEDCT_US_2020_03_01:733845009
has cross-reference: UMLS_CUI:C1334282
has cross-reference: UMLS_CUI:C1335329
alternative_term: Inverted papilloma of urinary tract
alternative_term: Papillary transitional cell neoplasm of the urinary tract
alternative_term: urinary tract inverted papilloma
has_obo_namespace: disease_ontology
id: DOID:5433
in subset: NCIthesaurus

scrapie
type: Class
subclass of: prion disease
imported from: doid.owl
has cross-reference: MESH:D012608
has cross-reference: SNOMEDCT_US_2020_03_01:35103004
has cross-reference: UMLS_CUI:C0036457
has_obo_namespace: disease_ontology
id: DOID:5434

variant Creutzfeldt-Jakob disease
type: Class
subclass of: prion disease
imported from: doid.owl
has cross-reference: MESH:D016643
has cross-reference: SNOMEDCT_US_2020_03_01:52869003
has cross-reference: UMLS_CUI:C0085209
alternative_term: Bovine spongiform encephalopathy
alternative_term: bovine spongiform encephalopathy
has_obo_namespace: disease_ontology
id: DOID:5435

eccrine acrospiroma
type: Class
subclass of: eccrine sweat gland neoplasm
imported from: doid.owl
has cross-reference: MESH:D018250
has cross-reference: NCI:C7568
has cross-reference: SNOMEDCT_US_2020_03_01:254719003
has cross-reference: UMLS_CUI:C0206671
alternative_term: Eccrine acrospiroma
alternative_term: Eccrine hidradenoma
alternative_term: Eccrine hidradenoma of skin
alternative_term: Poroma
has_obo_namespace: disease_ontology
id: DOID:5442
in subset: NCIthesaurus

clear cell hidradenoma
type: Class
subclass of: hidradenoma
imported from: doid.owl
has cross-reference: NCI:C7567
has cross-reference: SNOMEDCT_US_2020_03_01:254719003
has cross-reference: UMLS_CUI:C1370701
alternative_term: Clear cell Hidradenoma
alternative_term: Clear cell hidradenoma
alternative_term: Clear cell myoepithelioma
has_obo_namespace: disease_ontology
id: DOID:5443
in subset: NCIthesaurus

spiradenoma
type: Class
subclass of: apocrine sweat gland neoplasm
imported from: doid.owl
has_alternative_id: DOID:1617
has cross-reference: NCI:C4170
has cross-reference: SNOMEDCT_US_2020_03_01:403938001
has cross-reference: UMLS_CUI:C0334347
alternative_term: Eccrine spiradenoma
alternative_term: Eccrine spiradenoma of skin
alternative_term: benign eccrine spiradenoma
has_obo_namespace: disease_ontology
id: DOID:5444
in subset: NCIthesaurus

syringocystadenoma papilliferum
type: Class
subclass of: apocrine sweat gland neoplasm
imported from: doid.owl
has cross-reference: GARD:5100
has cross-reference: MESH:D000074009
has cross-reference: NCI:C4172
has cross-reference: SNOMEDCT_US_2020_03_01:8934006
has cross-reference: UMLS_CUI:C0406803
alternative_term: Papillary Syringadenoma
alternative_term: Papillary syringadenoma
alternative_term: Syringocystadenoma papilliferum
has_obo_namespace: disease_ontology
id: DOID:5445
in subset: NCIthesaurus

pulmonary venoocclusive disease
type: Class
subclass of: pulmonary hypertension
imported from: doid.owl
has cross-reference: GARD:10153
has cross-reference: MESH:D011668
has cross-reference: NCI:C85039
has cross-reference: OMIM:265450
has cross-reference: SNOMEDCT_US_2020_03_01:89420002
has cross-reference: UMLS_CUI:C0034091
alternative_term: pulmonary veno-occlusive disease
has_obo_namespace: disease_ontology
id: DOID:5453
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

biliary papillomatosis
type: Class
subclass of: biliary tract benign neoplasm
subclass of: papilloma
textual definition: A biliary tract benign neoplasm characterized by multiple papillary tumors in the intrahepatic and/or extrahepatic biliary tree.
imported from: doid.owl
has cross-reference: NCI:C65198
has cross-reference: SNOMEDCT_US_2020_03_01:128663007
has cross-reference: UMLS_CUI:C1266038
alternative_term: bile duct papillomatosis
has_obo_namespace: disease_ontology
id: DOID:5468
in subset: NCIthesaurus

cystadenofibroma
type: Class
subclass of: ovarian benign neoplasm
subclass of: adenofibroma
textual definition: An ovarian benign neoplasm that is composed_of epithelial ovarian tissue.
imported from: doid.owl
has cross-reference: MESH:D062625
has cross-reference: NCI:C8985
has cross-reference: SNOMEDCT_US_2020_03_01:2962009
has cross-reference: UMLS_CUI:C0334317
alternative_term: Cystadenofibroma
has_obo_namespace: disease_ontology
id: DOID:5482
in subset: NCIthesaurus

synovial sarcoma
type: Class
subclass of: synovium cancer
textual definition: A synovium cancer which develops in the synovial membrane of the joints.
imported from: doid.owl
has cross-reference: GARD:7721
has cross-reference: MESH:D013584
has cross-reference: NCI:C3400
has cross-reference: OMIM:300813
has cross-reference: SNOMEDCT_US_2020_03_01:63211008
has cross-reference: UMLS_CUI:C0039101
has_obo_namespace: disease_ontology
id: DOID:5485
in subset: NCIthesaurus
comment: Xref MGI.

lice infestation
type: Class
subclass of: parasitic ectoparasitic infectious disease
textual definition: A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera.
imported from: doid.owl
has_alternative_id: DOID:5490
has_alternative_id: DOID:5523
has cross-reference: ICD10CM:B85.2
has cross-reference: ICD9CM:132.9
has cross-reference: MESH:D010373
has cross-reference: NCI:C128401
has cross-reference: SNOMEDCT_US_2020_03_01:74949007
has cross-reference: UMLS_CUI:C0030756
alternative_term: Infestation by Pediculus
alternative_term: Lice infestation
alternative_term: Louse infestation
alternative_term: Pediculosis + lice
alternative_term: Pediculosis and phthirus infection
alternative_term: Pediculosis and phthirus infections
alternative_term: Pediculosis and phthirus infestation
alternative_term: mixed pediculosis
alternative_term: mixed pediculosis infestation
alternative_term: pediculosis
alternative_term: pediculosis and phthirus infection
has_obo_namespace: disease_ontology
id: DOID:5502
in subset: NCIthesaurus

spinal cord ependymoma
type: Class
subclass of: spinal cord glioma
textual definition: A spinal cord glioma that has_material_basis_in cells linking the spinal cord central canal.
imported from: doid.owl
has cross-reference: NCI:C3875
has cross-reference: SNOMEDCT_US_2020_03_01:254949006
has cross-reference: UMLS_CUI:C0238432
alternative_term: Ependymal neoplasm of the Spinal Cord
has_obo_namespace: disease_ontology
id: DOID:5503
in subset: DO cancer slim
in subset: NCIthesaurus

tanycytic ependymoma
type: Class
subclass of: benign ependymoma
imported from: doid.owl
has cross-reference: NCI:C6903
has cross-reference: SNOMEDCT_US_2020_03_01:57706008
has cross-reference: UMLS_CUI:C1370500
has_obo_namespace: disease_ontology
id: DOID:5504
in subset: NCIthesaurus

papillary ependymoma
type: Class
subclass of: benign ependymoma
imported from: doid.owl
has cross-reference: MESH:D004806
has cross-reference: NCI:C4319
has cross-reference: SNOMEDCT_US_2020_03_01:112686007
has cross-reference: UMLS_CUI:C0334578
has_obo_namespace: disease_ontology
id: DOID:5505
in subset: NCIthesaurus

nasal cavity squamous cell carcinoma
type: Class
subclass of: nasal cavity cancer
subclass of: squamous cell carcinoma
textual definition: A nasal cavity carcinoma that has_material_basis_in squamous cells.
imported from: doid.owl
has cross-reference: NCI:C8192
has cross-reference: UMLS_CUI:C0280333
alternative_term: squamous cell carcinoma of the nasal cavity
has_obo_namespace: disease_ontology
has_related_synonym: squamous cell carcinoma of nasal cavity
id: DOID:5515
in subset: DO cancer slim
in subset: NCIthesaurus

stomach carcinoma
type: Class
subclass of: stomach cancer
subclass of: carcinoma
textual definition: A stomach cancer that is located_in the stomach.
imported from: doid.owl
has cross-reference: EFO:0000178
has cross-reference: NCI:C4911
has cross-reference: SNOMEDCT_US_2020_03_01:154446008
has cross-reference: UMLS_CUI:C0699791
alternative_term: cancer of the stomach
alternative_term: carcinoma of stomach
alternative_term: gastric carcinoma
has_obo_namespace: disease_ontology
id: DOID:5517
in subset: NCIthesaurus

pneumonia
type: Class
subclass of: lung disease
textual definition: A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.
imported from: doid.owl
has_alternative_id: DOID:10509
has_alternative_id: DOID:11742
has_alternative_id: DOID:5871
has cross-reference: MESH:D011014
has cross-reference: NCI:C3333
has cross-reference: SNOMEDCT_US_2020_03_01:266391003
has cross-reference: UMLS_CUI:C0032285
alternative_term: acute pneumonia
has_obo_namespace: disease_ontology
id: DOID:552
in subset: NCIthesaurus

basaloid squamous cell carcinoma
type: Class
subclass of: squamous cell carcinoma
subclass of: basal cell carcinoma
textual definition: A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.
imported from: doid.owl
has cross-reference: NCI:C54244
has cross-reference: SNOMEDCT_US_2020_03_01:128634009
has cross-reference: UMLS_CUI:C1266005
alternative_term: Basaloid carcinoma
alternative_term: Basaloid squamous cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:5522
in subset: NCIthesaurus

anal squamous cell carcinoma
type: Class
subclass of: squamous cell carcinoma
subclass of: anal carcinoma
textual definition: An anal carcinoma that arises near the squamocolumnar junction.
imported from: doid.owl
has cross-reference: NCI:C9161
has cross-reference: SNOMEDCT_US_2020_03_01:255084004
has cross-reference: UMLS_CUI:C1412036
alternative_term: Epidermoid anal carcinoma
has_obo_namespace: disease_ontology
id: DOID:5525
in subset: NCIthesaurus

gallbladder squamous cell carcinoma
type: Class
subclass of: squamous cell carcinoma
subclass of: gallbladder carcinoma
textual definition: A squamous cell carcinoma that is located_in the gallbladder.
imported from: doid.owl
has cross-reference: NCI:C9170
has cross-reference: UMLS_CUI:C0279658
alternative_term: Epidermoid gallbladder carcinoma
has_obo_namespace: disease_ontology
has_related_synonym: squamous cell carcinoma of the gallbladder
id: DOID:5535
in subset: NCIthesaurus

mature teratoma
type: Class
subclass of: teratoma
textual definition: A teratoma that is composed exclusively of mature tissues derived from two or three germ layers.
imported from: doid.owl
has cross-reference: NCI:C9015
has cross-reference: SNOMEDCT_US_2020_03_01:55818009
has cross-reference: UMLS_CUI:C1368910
has_obo_namespace: disease_ontology
id: DOID:5566
in subset: NCIthesaurus

ovarian germ cell teratoma
type: Class
subclass of: ovarian germ cell cancer
imported from: doid.owl
has cross-reference: NCI:C8110
has cross-reference: SNOMEDCT_US_2020_03_01:716077006
has cross-reference: UMLS_CUI:C0280131
alternative_term: germ cell teratoma of Ovary
has_obo_namespace: disease_ontology
id: DOID:5567
in subset: NCIthesaurus

malignant syringoma
type: Class
subclass of: eccrine sweat gland cancer
imported from: doid.owl
alternative_term: Microcystic Adnexal carcinoma
alternative_term: Microcystic adnexal carcinoma of skin
alternative_term: Syringomatous carcinoma
has_obo_namespace: disease_ontology
id: DOID:5569

kidney disease
type: Class
subclass of: urinary system disease
textual definition: A urinary system disease that is located_in the kidney.
imported from: doid.owl
has_alternative_id: DOID:11705
has cross-reference: EFO:0003086
has cross-reference: ICD10CM:N08
has cross-reference: MESH:D007674
has cross-reference: NCI:C3149
has cross-reference: SNOMEDCT_US_2020_03_01:266612003
has cross-reference: UMLS_CUI:C0022658
alternative_term: impaired renal function disease
alternative_term: nephropathy
has_obo_namespace: disease_ontology
id: DOID:557
in subset: DO FlyBase slim
in subset: NCIthesaurus

Beckwith-Wiedemann syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations.
imported from: doid.owl
has cross-reference: GARD:3343
has cross-reference: ICD10CM:Q87.3
has cross-reference: MESH:D001506
has cross-reference: NCI:C34415
has cross-reference: OMIM:130650
has cross-reference: ORDO:116
has cross-reference: SNOMEDCT_US_2020_03_01:81780002
has cross-reference: UMLS_CUI:C0004903
has_obo_namespace: disease_ontology
id: DOID:5572
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

VIPoma
type: Class
subclass of: neuroendocrine tumor
imported from: doid.owl
has cross-reference: GARD:5493
has cross-reference: MESH:D003969
has cross-reference: NCI:C26749
has cross-reference: SNOMEDCT_US_2020_03_01:447643008
has cross-reference: UMLS_CUI:C0011993
alternative_term: VIP- Secreting tumor
alternative_term: Vasoactive intestinal peptide-secreting tumor
alternative_term: Vipoma, malignant
alternative_term: malignant vasoactive intestinal peptide-secreting tumor
has_obo_namespace: disease_ontology
id: DOID:5574
in subset: NCIthesaurus

gastrinoma
type: Class
subclass of: neuroendocrine tumor
textual definition: A neuroendocrine tumor that results_in an overproduction of gastric acid.
imported from: doid.owl
has cross-reference: MESH:D015408
has cross-reference: NCI:C3050
has cross-reference: SNOMEDCT_US_2020_03_01:16189002
has cross-reference: UMLS_CUI:C0017150
alternative_term: Gastrin Secreting tumor
alternative_term: Gastrin cell tumour
alternative_term: malignant gastrinoma
has_obo_namespace: disease_ontology
id: DOID:5577
in subset: NCIthesaurus

pancreatic gastrinoma
type: Class
subclass of: islet cell tumor
imported from: doid.owl
has cross-reference: NCI:C9069
has cross-reference: UMLS_CUI:C1368066
alternative_term: pancreatic G-cell tumor
has_obo_namespace: disease_ontology
id: DOID:5580
in subset: NCIthesaurus

breast papillary carcinoma
type: Class
subclass of: breast carcinoma
textual definition: A breast carcinoma that is characterized by the presence of arborescent fibrovascular stalks lined by epithelial cells, grossly forming a circumscribed mass.
imported from: doid.owl
has_alternative_id: DOID:6800
has cross-reference: NCI:C6870
has cross-reference: UMLS_CUI:C1336027
alternative_term: Papillary carcinoma of the breast
alternative_term: breast solid papillary carcinoma
has_obo_namespace: disease_ontology
has_related_synonym: papillary carcinoma of breast
has_related_synonym: solid papillary carcinoma of the breast
id: DOID:5592
in subset: NCIthesaurus

T-cell acute lymphoblastic leukemia
type: Class
subclass of: lymphoma
subclass of: DOID 9952
textual definition: An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood.
imported from: doid.owl
has_alternative_id: DOID:5599
has cross-reference: ICD10CM:C91.5
has cross-reference: MESH:D015459
has cross-reference: NCI:C3184
has cross-reference: SNOMEDCT_US_2020_03_01:77430005
has cross-reference: UMLS_CUI:C0023493
alternative_term: Precursor T Lymphoblastic Leukemia
alternative_term: T Acute Lymphoblastic Leukemia
alternative_term: T-cell acute lymphocytic leukaemia
alternative_term: acute T cell leukaemia
alternative_term: acute T cell leukemia
alternative_term: precursor T-lymphoblastic lymphoma/leukemia
has_obo_namespace: disease_ontology
id: DOID:5603
in subset: DO cancer slim
in subset: NCIthesaurus

adult acute lymphocytic leukemia
type: Class
subclass of: DOID 9952
textual definition: An acute lymphocytic leukemia occurring during adulthood.
imported from: doid.owl
has cross-reference: NCI:C4967
has cross-reference: UMLS_CUI:C0751606
alternative_term: adult ALL
alternative_term: adult acute lymphoid Leukemia
has_obo_namespace: disease_ontology
id: DOID:5604
in subset: DO cancer slim
in subset: NCIthesaurus

dental pulp calcification
type: Class
subclass of: dental pulp disease
imported from: doid.owl
has cross-reference: ICD10CM:K04.2
has cross-reference: MESH:D003784
has cross-reference: SNOMEDCT_US_2020_03_01:57602001
has cross-reference: UMLS_CUI:C0011401
alternative_term: pulp calcification
alternative_term: pulp calcifications
alternative_term: pulpal calcifications
has_obo_namespace: disease_ontology
id: DOID:5608

trigeminal nerve disease
type: Class
subclass of: cranial nerve disease
imported from: doid.owl
has cross-reference: ICD9CM:350.8
has cross-reference: UMLS_CUI:C0029834
has_obo_namespace: disease_ontology
id: DOID:561

spinal cancer
type: Class
subclass of: spinal cord disease
subclass of: central nervous system cancer
textual definition: A central nervous system cancer that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).
imported from: doid.owl
has_alternative_id: DOID:3638
has_alternative_id: DOID:7225
has cross-reference: ICD10CM:C72.0
has cross-reference: ICD9CM:192.2
has cross-reference: MESH:D013120
has cross-reference: MESH:D013125
has cross-reference: NCI:C3381
has cross-reference: NCI:C3572
has cross-reference: SNOMEDCT_US_2020_03_01:126962006
has cross-reference: SNOMEDCT_US_2020_03_01:709289008
has cross-reference: SNOMEDCT_US_2020_03_01:94068003
has cross-reference: UMLS_CUI:C0037930
has cross-reference: UMLS_CUI:C0037939
has cross-reference: UMLS_CUI:C0153646
alternative_term: Intraspinal tumor
alternative_term: malignant tumor of the Spinal Cord
alternative_term: spinal cord cancer
alternative_term: spinal cord neoplasm
alternative_term: tumor of the Spinal Cord
has_obo_namespace: disease_ontology
has_related_synonym: spinal neoplasm
id: DOID:5612
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

eye disease
type: Class
subclass of: sensory system disease
textual definition: An eye and adnexa disease that is located_in the eye.
imported from: doid.owl
has_alternative_id: DOID:2933
has cross-reference: ICD10CM:H44
has cross-reference: ICD9CM:379.90
has cross-reference: MESH:D005128
has cross-reference: NCI:C26767
has cross-reference: SNOMEDCT_US_2020_03_01:371409005
has cross-reference: UMLS_CUI:C0015397
has_obo_namespace: disease_ontology
id: DOID:5614
in subset: DO FlyBase slim
in subset: NCIthesaurus

histiocytic and dendritic cell cancer
type: Class
subclass of: hematologic cancer
textual definition: A sarcoma and hematologic cancer that derives_from follicular lymphoma.
imported from: doid.owl
has cross-reference: NCI:C9294
has cross-reference: UMLS_CUI:C1334030
alternative_term: histiocytic and dendritic cell
has_obo_namespace: disease_ontology
id: DOID:5621
in subset: NCIthesaurus

optic nerve sheath meningioma
type: Class
subclass of: optic nerve neoplasm
imported from: doid.owl
has cross-reference: NCI:C4538
has cross-reference: SNOMEDCT_US_2020_03_01:254978007
has cross-reference: UMLS_CUI:C0346328
alternative_term: meningioma of optic nerve sheath
alternative_term: optic nerve Sheath meningioma
has_obo_namespace: disease_ontology
id: DOID:5632
in subset: NCIthesaurus

cervical adenosquamous carcinoma
type: Class
subclass of: squamous cell carcinoma
subclass of: cervical cancer
textual definition: A cervical carcinoma that derives_from squamous cells and gland-like cells.
imported from: doid.owl
has cross-reference: NCI:C4519
has cross-reference: SNOMEDCT_US_2020_03_01:254888007
has cross-reference: UMLS_CUI:C0346202
alternative_term: Adenosquamous carcinoma of cervix
alternative_term: Adenosquamous cell carcinoma of the Cervix Uteri
has_obo_namespace: disease_ontology
id: DOID:5636
in subset: NCIthesaurus

tricuspid valve prolapse
type: Class
subclass of: tricuspid valve disease
imported from: doid.owl
has cross-reference: MESH:D014263
has cross-reference: SNOMEDCT_US_2020_03_01:253383003
has cross-reference: UMLS_CUI:C0040962
has_obo_namespace: disease_ontology
id: DOID:5644

choroid plexus carcinoma
type: Class
subclass of: carcinoma
subclass of: choroid plexus cancer
textual definition: A choroid plexus cancer that has_material_basis_in epithelial cells of the choroid plexus.
imported from: doid.owl
has_alternative_id: DOID:5647
has cross-reference: GARD:8238
has cross-reference: MESH:C562943
has cross-reference: NCI:C4533
has cross-reference: NCI:C4715
has cross-reference: SNOMEDCT_US_2020_03_01:188292007
has cross-reference: SNOMEDCT_US_2020_03_01:88252006
has cross-reference: UMLS_CUI:C0346289
has cross-reference: UMLS_CUI:C0431109
has_obo_namespace: disease_ontology
id: DOID:5648
in subset: DO cancer slim
in subset: NCIthesaurus

cranial nerve disease
type: Class
subclass of: DOID 870
textual definition: A neuropathy that is located_in one of the twelve cranial nerves.
imported from: doid.owl
has cross-reference: ICD10CM:G52.9
has cross-reference: ICD9CM:352.9
has cross-reference: MESH:D003389
has cross-reference: NCI:C26733
has cross-reference: SNOMEDCT_US_2020_03_01:73013002
has cross-reference: UMLS_CUI:C0010266
alternative_term: Cranial nerve disorder
alternative_term: disorder of cranial nerve
has_obo_namespace: disease_ontology
id: DOID:5656
in subset: NCIthesaurus

lipid-rich carcinoma
type: Class
subclass of: breast carcinoma
textual definition: A breast carcinoma characterized by the presence of malignant epithelial cells with clear cytoplasm which contains neutral lipids.
imported from: doid.owl
has cross-reference: NCI:C4152
has cross-reference: SNOMEDCT_US_2020_03_01:189655006
has cross-reference: UMLS_CUI:C0334318
has_obo_namespace: disease_ontology
id: DOID:5658
in subset: NCIthesaurus

labyrinthine dysfunction
type: Class
subclass of: inner ear disease
imported from: doid.owl
has cross-reference: ICD10CM:H83.2
has cross-reference: ICD9CM:386.5
has cross-reference: SNOMEDCT_US_2020_03_01:5239005
has cross-reference: UMLS_CUI:C0155514
has_obo_namespace: disease_ontology
id: DOID:566

external ear cancer
type: Class
subclass of: external ear disease
subclass of: ear cancer
textual definition: An ear cancer that is located_in the external ear.
imported from: doid.owl
has cross-reference: NCI:C4653
has cross-reference: SNOMEDCT_US_2020_03_01:277156006
has cross-reference: UMLS_CUI:C0349576
alternative_term: malignant neoplasm of the External ear
alternative_term: malignant tumor of external ear
has_obo_namespace: disease_ontology
id: DOID:5665
in subset: NCIthesaurus

large intestine cancer
type: Class
subclass of: intestinal cancer
textual definition: An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.
imported from: doid.owl
has_alternative_id: DOID:1994
has_alternative_id: DOID:1997
has cross-reference: ICD10CM:C18.9
has cross-reference: NCI:C4978
has cross-reference: SNOMEDCT_US_2020_03_01:93854002
has cross-reference: UMLS_CUI:C0346629
has_obo_namespace: disease_ontology
id: DOID:5672
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

cribriform carcinoma
type: Class
subclass of: breast carcinoma
textual definition: A breast carcinoma that is characterized by an irregular cribriform growth pattern, nuclear grade I in at least 90% of cells, and absent myoepithelial cells.
imported from: doid.owl
has cross-reference: MESH:D000230
has cross-reference: NCI:C3680
has cross-reference: SNOMEDCT_US_2020_03_01:30156004
has cross-reference: UMLS_CUI:C0205643
alternative_term: Cribriform carcinoma
alternative_term: ductal carcinoma, cribriform type
has_obo_namespace: disease_ontology
id: DOID:5675
in subset: NCIthesaurus

retinal disease
type: Class
subclass of: eye disease
textual definition: An eye disease that is located_in the retina.
imported from: doid.owl
has cross-reference: ICD10CM:H35.9
has cross-reference: ICD9CM:362.9
has cross-reference: MESH:D012164
has cross-reference: NCI:C26875
has cross-reference: SNOMEDCT_US_2020_03_01:29555009
has cross-reference: UMLS_CUI:C0035309
has_obo_namespace: disease_ontology
id: DOID:5679
in subset: NCIthesaurus

hereditary breast ovarian cancer syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome characterized by the higher than normal tendency associated with BRCA1 and BRCA2 to develop breast and ovarian cancers in genetically related families.
imported from: doid.owl
has cross-reference: MESH:D061325
has cross-reference: NCI:C8493
has cross-reference: SNOMEDCT_US_2020_03_01:718220008
has cross-reference: UMLS_CUI:C0677776
alternative_term: BRCA1- and BRCA2-associated hereditary breast and ovarian cancer
has_obo_namespace: disease_ontology
id: DOID:5683
in subset: NCIthesaurus
comment: Xref MGI.

spondyloepimetaphyseal dysplasia, Sponastrime type
type: Class
subclass of: autosomal recessive disease
subclass of: spondyloepimetaphyseal dysplasia
textual definition: A spondyloepimetaphyseal dysplasia that is characterized by spondylar and nasal changes, with striations of the metaphyses that has_material_basis_in autosomal recessive inheritance.
imported from: doid.owl
has cross-reference: NCI:C92206
has cross-reference: OMIM:271510
has cross-reference: UMLS_CUI:C0920349
alternative_term: Spondylar and nasal Alterations-Striated Metaphyses syndrome
alternative_term: sponastrime dysplasia
has_obo_namespace: disease_ontology
id: DOID:5684
in subset: NCIthesaurus

Werner syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers and that has_material_basis_in mutations in the WRN gene, on chromosome 8.
imported from: doid.owl
has cross-reference: GARD:7885
has cross-reference: MESH:D014898
has cross-reference: NCI:C3447
has cross-reference: OMIM:277700
has cross-reference: ORDO:902
has cross-reference: SNOMEDCT_US_2020_03_01:51626007
has cross-reference: UMLS_CUI:C0043119
alternative_term: WS
alternative_term: Werner's syndrome
alternative_term: adult premature ageing syndrome
alternative_term: adult progeria
has_obo_namespace: disease_ontology
id: DOID:5688
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

visual cortex disease
type: Class
subclass of: visual pathway disease
imported from: doid.owl
has cross-reference: ICD10CM:H47.6
has cross-reference: ICD9CM:377.7
has cross-reference: NCI:C35275
has cross-reference: SNOMEDCT_US_2020_03_01:128329001
has cross-reference: UMLS_CUI:C0234398
alternative_term: visual cortex dysfunction
has_obo_namespace: disease_ontology
id: DOID:5691
in subset: NCIthesaurus

aortic valve insufficiency
type: Class
subclass of: aortic valve disease
textual definition: An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle.
imported from: doid.owl
has_alternative_id: DOID:54
has_alternative_id: DOID:55
has cross-reference: ICD10CM:I06.1
has cross-reference: ICD9CM:395.1
has cross-reference: ICD9CM:396.3
has cross-reference: MESH:D001022
has cross-reference: NCI:C51223
has cross-reference: SNOMEDCT_US_2020_03_01:155283004
has cross-reference: SNOMEDCT_US_2020_03_01:194736003
has cross-reference: SNOMEDCT_US_2020_03_01:60234000
has cross-reference: UMLS_CUI:C0003504
has cross-reference: UMLS_CUI:C0155568
has cross-reference: UMLS_CUI:C0264774
alternative_term: Rheumatic aortic insufficiency
alternative_term: Rheumatic aortic regurgitation
alternative_term: Rheumatic aortic valve regurgitation
alternative_term: aortic incompetence
alternative_term: aortic insufficiency
alternative_term: aortic regurgitation
alternative_term: rheumatic aortic valve insufficiency
has_obo_namespace: disease_ontology
has_related_synonym: Corrigan's disease
id: DOID:57
in subset: NCIthesaurus

median neuropathy
type: Class
subclass of: mononeuritis of upper limb and mononeuritis multiplex
imported from: doid.owl
has cross-reference: ICD10CM:G56.10
has cross-reference: ICD9CM:354.1
has cross-reference: SNOMEDCT_US_2020_03_01:193127001
has cross-reference: UMLS_CUI:C0154742
has_obo_namespace: disease_ontology
id: DOID:571

hormone producing pituitary cancer
type: Class
subclass of: pituitary cancer
imported from: doid.owl
has_alternative_id: DOID:6254
has cross-reference: NCI:C7047
has cross-reference: NCI:C7911
has cross-reference: UMLS_CUI:C0278864
has cross-reference: UMLS_CUI:C0851693
alternative_term: Pituitary tumors, Hormone Producing
alternative_term: Somatotropinoma
alternative_term: growth hormone producing pituitary tumor
has_obo_namespace: disease_ontology
id: DOID:5716
in subset: NCIthesaurus

adrenal neuroblastoma
type: Class
subclass of: adrenal gland cancer
textual definition: An adrenal gland cancer that derives_from immature neuroblastic cells.
imported from: doid.owl
has cross-reference: NCI:C4827
has cross-reference: SNOMEDCT_US_2020_03_01:281562007
has cross-reference: UMLS_CUI:C0559460
alternative_term: neuroblastoma of Adrenal gland
has_obo_namespace: disease_ontology
id: DOID:5718
in subset: DO cancer slim
in subset: NCIthesaurus

mononeuritis of upper limb and mononeuritis multiplex
type: Class
subclass of: mononeuritis
imported from: doid.owl
has cross-reference: ICD9CM:354
has cross-reference: SNOMEDCT_US_2020_03_01:193125009
has cross-reference: UMLS_CUI:C0154741
has_obo_namespace: disease_ontology
id: DOID:572

optic atrophy
type: Class
subclass of: optic nerve disease
textual definition: An optic nerve disease that is characterized the death of the retinal ganglion cell axons that comprise the optic nerve.
imported from: doid.owl
has cross-reference: ICD10CM:H47.2
has cross-reference: ICD9CM:377.1
has cross-reference: MESH:D009896
has cross-reference: NCI:C34863
has cross-reference: OMIM:PS165500
has cross-reference: ORDO:98673
has cross-reference: SNOMEDCT_US_2020_03_01:155188004
has cross-reference: UMLS_CUI:C0029124
alternative_term: atrophy of optic disc
has_obo_namespace: disease_ontology
id: DOID:5723
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

nerve compression syndrome
type: Class
subclass of: peripheral nervous system disease
imported from: doid.owl
has_alternative_id: DOID:7318
has cross-reference: MESH:D009408
has cross-reference: NCI:C27221
has cross-reference: SNOMEDCT_US_2020_03_01:45781009
has cross-reference: UMLS_CUI:C0027743
has cross-reference: UMLS_CUI:C1510429
alternative_term: Compression neuropathy
alternative_term: Entrapment Neuropathy
alternative_term: entrapment neuropathy
alternative_term: peripheral nerve entrapment syndrome
has_obo_namespace: disease_ontology
id: DOID:573
in subset: NCIthesaurus

pyosalpinx
type: Class
subclass of: salpingitis
imported from: doid.owl
has cross-reference: ICD10CM:N70
has cross-reference: NCI:C34968
has cross-reference: SNOMEDCT_US_2020_03_01:155974004
has cross-reference: UMLS_CUI:C0034220
alternative_term: Pyosalpingitis
has_obo_namespace: disease_ontology
id: DOID:5732
in subset: NCIthesaurus

salpingitis
type: Class
subclass of: fallopian tube disease
textual definition: A fallopian tube disease that is characterized by inflammation of the fallopian tube.
imported from: doid.owl
has cross-reference: ICD10CM:N70.91
has cross-reference: MESH:D012488
has cross-reference: NCI:C26880
has cross-reference: SNOMEDCT_US_2020_03_01:155968004
has cross-reference: UMLS_CUI:C0036130
has_obo_namespace: disease_ontology
id: DOID:5733
in subset: NCIthesaurus

peripheral nervous system disease
type: Class
subclass of: DOID 863
textual definition: A nervous system disease that affects the peripheral nervous system.
imported from: doid.owl
has_alternative_id: DOID:13069
has cross-reference: NCI:C119734
has cross-reference: NCI:C27587
has cross-reference: UMLS_CUI:C0031117
has cross-reference: UMLS_CUI:C1335029
has_obo_namespace: disease_ontology
has_related_synonym: peripheral nerve disease
has_related_synonym: peripheral neuropathy
id: DOID:574
in subset: DO AGR slim
in subset: DO GXD slim
in subset: NCIthesaurus

pancreatic acinar cell adenocarcinoma
type: Class
subclass of: pancreatic adenocarcinoma
textual definition: A pancreatic adenocarcinoma that has_material_basis_in cells with morphological resemblance to acinar cells and is associated with increased serum lipase.
imported from: doid.owl
has cross-reference: NCI:C7977
has cross-reference: SNOMEDCT_US_2020_03_01:783771003
has cross-reference: UMLS_CUI:C0279661
alternative_term: pancreatic acinar cell carcinoma
has_obo_namespace: disease_ontology
id: DOID:5742
in subset: DO cancer slim
in subset: NCIthesaurus

ovarian serous cystadenocarcinoma
type: Class
subclass of: ovarian cystadenocarcinoma
textual definition: An ovary serous adenocarcinoma that has_material_basis_in glandular epithelium, in which cystic accumulations of retained secretions are formed.
imported from: doid.owl
has cross-reference: NCI:C7978
has cross-reference: UMLS_CUI:C0279663
alternative_term: serous cystadenoma
has_obo_namespace: disease_ontology
id: DOID:5746
in subset: DO cancer slim
in subset: NCIthesaurus

pulmonary valve disease
type: Class
subclass of: heart valve disease
imported from: doid.owl
has cross-reference: ICD9CM:424.3
has cross-reference: NCI:C78579
has cross-reference: SNOMEDCT_US_2020_03_01:76267008
has cross-reference: UMLS_CUI:C0034087
alternative_term: pulmonary valve disorder
has_obo_namespace: disease_ontology
id: DOID:5749
in subset: NCIthesaurus

endocervicitis
type: Class
subclass of: cervicitis
textual definition: A cervicitis that is located_in the endocervix.
imported from: doid.owl
has cross-reference: NCI:C26762
has cross-reference: SNOMEDCT_US_2020_03_01:155980007
has cross-reference: UMLS_CUI:C0014127
has_obo_namespace: disease_ontology
id: DOID:5757
in subset: NCIthesaurus

malignant mesenchymoma
type: Class
subclass of: mesenchymoma
imported from: doid.owl
has cross-reference: GARD:3369
has cross-reference: MESH:C535700
has cross-reference: NCI:C4268
has cross-reference: SNOMEDCT_US_2020_03_01:89623007
has cross-reference: UMLS_CUI:C0334492
alternative_term: Mesenchymoma, malignant
has_obo_namespace: disease_ontology
id: DOID:5758
in subset: NCIthesaurus

sebaceous gland neoplasm
type: Class
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: MESH:D012626
has cross-reference: NCI:C3363
has cross-reference: SNOMEDCT_US_2020_03_01:126491004
has cross-reference: UMLS_CUI:C0036503
alternative_term: Sebaceous neoplasm
has_obo_namespace: disease_ontology
id: DOID:5759
in subset: NCIthesaurus

proteinuria
type: Class
subclass of: kidney disease
textual definition: A kidney disease that is characterized by the presence of excess proteins in the urine.
imported from: doid.owl
has cross-reference: ICD10CM:R80
has cross-reference: ICD9CM:791.0
has cross-reference: MESH:D011507
has cross-reference: NCI:C38012
has cross-reference: SNOMEDCT_US_2020_03_01:144515004
has cross-reference: UMLS_CUI:C0033687
has_obo_namespace: disease_ontology
id: DOID:576
in subset: NCIthesaurus

verruciform xanthoma of skin
type: Class
subclass of: xanthomatosis
subclass of: skin disease
imported from: doid.owl
has cross-reference: NCI:C4478
has cross-reference: SNOMEDCT_US_2020_03_01:254756007
has cross-reference: UMLS_CUI:C0346054
alternative_term: Cutaneous Verruciform Xanthoma
alternative_term: Verruciform xanthoma
alternative_term: Verruciform xanthoma of skin
has_obo_namespace: disease_ontology
id: DOID:5769
in subset: NCIthesaurus

central nervous system hematologic cancer
type: Class
subclass of: hematologic cancer
subclass of: central nervous system cancer
textual definition: A hematologic cancer and central nervous system neoplasm that is located_in the central nervous system.
imported from: doid.owl
has cross-reference: NCI:C5503
has cross-reference: UMLS_CUI:C1332882
alternative_term: CNS hematopoietic tumor
has_obo_namespace: disease_ontology
has_related_synonym: hematopoietic neoplasm of central nervous system
id: DOID:5772
in subset: NCIthesaurus

oral submucous fibrosis
type: Class
subclass of: mouth disease
textual definition: A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
imported from: doid.owl
has_alternative_id: DOID:9679
has cross-reference: GARD:7264
has cross-reference: ICD10CM:K13.5
has cross-reference: ICD9CM:528.8
has cross-reference: MESH:D009914
has cross-reference: NCI:C34866
has cross-reference: SNOMEDCT_US_2020_03_01:32883009
has cross-reference: UMLS_CUI:C0029171
has cross-reference: UMLS_CUI:C0029172
alternative_term: Oral cavity Submucous Fibrosis
alternative_term: Oral submucosal fibrosis
alternative_term: Oral submucosal fibrosis, including of tongue
has_obo_namespace: disease_ontology
id: DOID:5773
in subset: NCIthesaurus

tympanic membrane disease
type: Class
subclass of: middle ear disease
imported from: doid.owl
has cross-reference: ICD10CM:H73.9
has cross-reference: ICD9CM:384.9
has cross-reference: SNOMEDCT_US_2020_03_01:21426000
has cross-reference: UMLS_CUI:C0041825
has_obo_namespace: disease_ontology
id: DOID:5782

uric acid nephrolithiasis
type: Class
subclass of: nephrolithiasis
textual definition: A nephrolithiasis that is characterized by stones composed predominantly uric acid.
imported from: doid.owl
has cross-reference: ICD9CM:274.11
has cross-reference: NCI:C123245
has cross-reference: OMIM:605990
has cross-reference: SNOMEDCT_US_2020_03_01:267441009
has cross-reference: UMLS_CUI:C0403719
alternative_term: acute urate nephropathy
has_obo_namespace: disease_ontology
id: DOID:580
in subset: NCIthesaurus

discrete subaortic stenosis
type: Class
subclass of: subvalvular aortic stenosis
imported from: doid.owl
has cross-reference: MESH:D021922
has cross-reference: UMLS_CUI:C0012628
has_obo_namespace: disease_ontology
id: DOID:5804

subvalvular aortic stenosis
type: Class
subclass of: aortic valve stenosis
textual definition: An aortic valve stenosis that is characterized by a narrowing of the section of the heart under the aortic valve resulting in left ventricular outflow obstruction.
imported from: doid.owl
has cross-reference: GARD:5052
has cross-reference: MESH:D001020
has cross-reference: NCI:C85172
has cross-reference: SNOMEDCT_US_2020_03_01:250915007
has cross-reference: UMLS_CUI:C0340375
has_obo_namespace: disease_ontology
id: DOID:5805
in subset: NCIthesaurus

purine nucleoside phosphorylase deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: combined T cell and B cell immunodeficiency
textual definition: A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder that has_material_basis_in mutation in the PNP gene and characterized mainly by decreased T-cell function.
imported from: doid.owl
has cross-reference: GARD:4606
has cross-reference: ICD10CM:D81.5
has cross-reference: MESH:C562587
has cross-reference: NCI:C3963
has cross-reference: OMIM:613179
has cross-reference: ORDO:760
has cross-reference: SNOMEDCT_US_2020_03_01:60743005
has cross-reference: UMLS_CUI:C0268125
alternative_term: PNP deficiency
alternative_term: Purine nucleoside phosphorylase deficiency
alternative_term: Purine-Nucleoside Phosphorylase deficiency
alternative_term: deficiency of inosine phosphorylase
has_obo_namespace: disease_ontology
id: DOID:5813
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

composite lymphoma
type: Class
subclass of: B-cell lymphoma
textual definition: A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time.
imported from: doid.owl
has cross-reference: MESH:D058617
has cross-reference: NCI:C38661
has cross-reference: UMLS_CUI:C0545080
has_obo_namespace: disease_ontology
id: DOID:5820
in subset: NCIthesaurus

gray zone lymphoma
type: Class
subclass of: lymphoma
textual definition: A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas.
imported from: doid.owl
has cross-reference: GARD:10897
has cross-reference: NCI:C37869
has cross-reference: SNOMEDCT_US_2020_03_01:722954005
has cross-reference: UMLS_CUI:C1333878
has_obo_namespace: disease_ontology
id: DOID:5822
in subset: NCIthesaurus

breast lymphoma
type: Class
subclass of: lymphoma
subclass of: breast cancer
textual definition: A breast cancer that arises_from lymphocytes.
imported from: doid.owl
has cross-reference: SNOMEDCT_US_2020_03_01:278052009
has cross-reference: UMLS_CUI:C0349669
alternative_term: Lymphoma of the breast
alternative_term: lymphoma of breast
alternative_term: malignant lymphoma of breast
has_obo_namespace: disease_ontology
id: DOID:5826

endometrioid ovary carcinoma
type: Class
subclass of: ovary adenocarcinoma
textual definition: An ovary adenocarcinoma that has_material_basis_in endometrial tissue.
imported from: doid.owl
has cross-reference: NCI:C7979
has cross-reference: SNOMEDCT_US_2020_03_01:254852002
has cross-reference: UMLS_CUI:C0346163
alternative_term: Ovarian endometrioid carcinoma
alternative_term: endometrioid carcinoma ovary
has_obo_namespace: disease_ontology
has_related_synonym: endometrioid carcinoma of ovary
id: DOID:5828
in subset: NCIthesaurus

hemolytic anemia
type: Class
subclass of: normocytic anemia
imported from: doid.owl
has cross-reference: ICD10CM:D55-D59
has cross-reference: MESH:D000743
has cross-reference: NCI:C34376
has cross-reference: OMIM:266120
has cross-reference: OMIM:612631
has cross-reference: SNOMEDCT_US_2020_03_01:61261009
has cross-reference: UMLS_CUI:C0002878
alternative_term: ANEMIA HEMOLYTIC
has_obo_namespace: disease_ontology
id: DOID:583
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS].

spermatocytoma
type: Class
subclass of: germ cell cancer
subclass of: testicular cancer
imported from: doid.owl
has cross-reference: NCI:C39921
has cross-reference: SNOMEDCT_US_2020_03_01:9294008
has cross-reference: UMLS_CUI:C0334517
alternative_term: Spermatocytic Seminoma
alternative_term: Spermatocytic seminoma
has_obo_namespace: disease_ontology
id: DOID:5834
in subset: NCIthesaurus

extragonadal seminoma
type: Class
subclass of: seminoma
imported from: doid.owl
has_alternative_id: DOID:6136
has cross-reference: NCI:C7327
has cross-reference: UMLS_CUI:C1333502
alternative_term: primary extragonadal seminoma
has_obo_namespace: disease_ontology
id: DOID:5838
in subset: NCIthesaurus

testis seminoma
type: Class
subclass of: germ cell cancer
subclass of: testicular cancer
imported from: doid.owl
has cross-reference: MESH:D018239
has cross-reference: NCI:C9309
has cross-reference: SNOMEDCT_US_2020_03_01:443675005
has cross-reference: UMLS_CUI:C0036631
alternative_term: Seminoma of testis
alternative_term: Seminoma testis
alternative_term: testicular Seminoma Pure
has_obo_namespace: disease_ontology
id: DOID:5842
in subset: NCIthesaurus

myocardial infarction
type: Class
subclass of: coronary artery disease
textual definition: A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.
imported from: doid.owl
has cross-reference: EFO:0000612
has cross-reference: ICD10CM:I21
has cross-reference: MESH:D009203
has cross-reference: NCI:C27996
has cross-reference: OMIM:608557
has cross-reference: SNOMEDCT_US_2020_03_01:66514008
has cross-reference: UMLS_CUI:C0027051
alternative_term: Myocardial infarct
alternative_term: heart attack
has_obo_namespace: disease_ontology
id: DOID:5844
in subset: NCIthesaurus
comment: Xref MGI.

posterior myocardial infarction
type: Class
subclass of: myocardial infarction
imported from: doid.owl
has cross-reference: SNOMEDCT_US_2020_03_01:194800006
has cross-reference: UMLS_CUI:C0340319
alternative_term: Posterior myocardial infarction
has_obo_namespace: disease_ontology
id: DOID:5847

nephrolithiasis
type: Class
subclass of: kidney disease
textual definition: A kidney disease characterized by the formation of stoney concentrations in the kidneys.
imported from: doid.owl
has cross-reference: EFO:0004253
has cross-reference: ICD10CM:N20
has cross-reference: ICD9CM:592
has cross-reference: SNOMEDCT_US_2020_03_01:155867005
has cross-reference: UMLS_CUI:C0156257
alternative_term: Stone - kidney/ureter
alternative_term: kidney stones
has_obo_namespace: disease_ontology
id: DOID:585
comment: OMIM mapping confirmed by DO. [SN].

inferior myocardial infarction
type: Class
subclass of: myocardial infarction
imported from: doid.owl
has cross-reference: MESH:D056989
has cross-reference: SNOMEDCT_US_2020_03_01:194804002
has cross-reference: UMLS_CUI:C0340305
alternative_term: Inferior myocardial infarction
has_obo_namespace: disease_ontology
id: DOID:5850

anteroseptal myocardial infarction
type: Class
subclass of: myocardial infarction
imported from: doid.owl
has cross-reference: MESH:D056988
has cross-reference: UMLS_CUI:C0262565
has_obo_namespace: disease_ontology
id: DOID:5855

eosinophilic pneumonia
type: Class
subclass of: pneumonia
textual definition: A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.
imported from: doid.owl
has cross-reference: GARD:107
has cross-reference: ICD10CM:J82
has cross-reference: MESH:D011657
has cross-reference: NCI:C35150
has cross-reference: SNOMEDCT_US_2020_03_01:196145005
has cross-reference: UMLS_CUI:C1527407
alternative_term: Pneumonia, eosinophilic
has_obo_namespace: disease_ontology
id: DOID:5870
in subset: NCIthesaurus

retroperitoneal cancer
type: Class
subclass of: organ system cancer
textual definition: An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.
imported from: doid.owl
has_alternative_id: DOID:12340
has_alternative_id: DOID:9860
has cross-reference: ICD10CM:C48
has cross-reference: ICD10CM:C48.0
has cross-reference: ICD9CM:158
has cross-reference: ICD9CM:158.0
has cross-reference: MESH:D012186
has cross-reference: NCI:C3357
has cross-reference: NCI:C3537
has cross-reference: SNOMEDCT_US_2020_03_01:187801002
has cross-reference: SNOMEDCT_US_2020_03_01:254617008
has cross-reference: SNOMEDCT_US_2020_03_01:363420003
has cross-reference: UMLS_CUI:C0035358
has cross-reference: UMLS_CUI:C0153464
has cross-reference: UMLS_CUI:C0153465
alternative_term: malignant neoplasm of retroperitoneum and peritoneum
alternative_term: malignant tumor of peritoneum and retroperitoneum
alternative_term: neoplasm of retroperitoneum
alternative_term: neoplasm of the retroperitoneum
alternative_term: retroperitoneal neoplasm
alternative_term: tumor of retroperitoneum
has_obo_namespace: disease_ontology
has_related_synonym: malignant neoplasm of retroperitoneum
has_related_synonym: malignant retroperitoneal cancer
id: DOID:5875
in subset: DO MGI slim
in subset: NCIthesaurus

apocrine sweat gland neoplasm
type: Class
subclass of: sweat gland benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C6798
has cross-reference: UMLS_CUI:C1332318
alternative_term: Apocrine tumor
has_obo_namespace: disease_ontology
id: DOID:5876
in subset: NCIthesaurus

congenital hemolytic anemia
type: Class
subclass of: physical disorder
subclass of: hemolytic anemia
imported from: doid.owl
has cross-reference: GARD:6167
has cross-reference: ICD10CM:D58.9
has cross-reference: ICD9CM:282
has cross-reference: MESH:D000745
has cross-reference: NCI:C34379
has cross-reference: SNOMEDCT_US_2020_03_01:42601008
has cross-reference: UMLS_CUI:C0002881
alternative_term: congenital hemolytic anaemia
alternative_term: hereditary hemolytic anaemia
alternative_term: hereditary hemolytic anemia
has_obo_namespace: disease_ontology
id: DOID:589
in subset: NCIthesaurus

phobic disorder
type: Class
subclass of: anxiety disorder
textual definition: An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation.
imported from: doid.owl
has cross-reference: ICD10CM:F40
has cross-reference: ICD9CM:300.20
has cross-reference: MESH:D010698
has cross-reference: NCI:C35420
has cross-reference: SNOMEDCT_US_2020_03_01:52039009
has cross-reference: UMLS_CUI:C0349231
has_obo_namespace: disease_ontology
id: DOID:591
in subset: NCIthesaurus

agoraphobia
type: Class
subclass of: phobic disorder
textual definition: A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.
imported from: doid.owl
has cross-reference: ICD10CM:F40.0
has cross-reference: MESH:D000379
has cross-reference: NCI:C34362
has cross-reference: SNOMEDCT_US_2020_03_01:154885006
has cross-reference: UMLS_CUI:C0001818
alternative_term: Fear of open spaces
has_obo_namespace: disease_ontology
id: DOID:593
in subset: NCIthesaurus

panic disorder
type: Class
subclass of: anxiety disorder
textual definition: An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.
imported from: doid.owl
has cross-reference: EFO:0004262
has cross-reference: ICD10CM:F41.0
has cross-reference: MESH:D016584
has cross-reference: NCI:C34890
has cross-reference: OMIM:167870
has cross-reference: OMIM:607853
has cross-reference: OMIM:609985
has cross-reference: SNOMEDCT_US_2020_03_01:191705007
has cross-reference: UMLS_CUI:C0030319
alternative_term: panic anxiety syndrome
has_obo_namespace: disease_ontology
id: DOID:594
in subset: NCIthesaurus
comment: Xref MGI.

malignant peripheral nerve sheath tumor
type: Class
subclass of: peripheral nerve sheath neoplasm
imported from: doid.owl
has cross-reference: GARD:10872
has cross-reference: MESH:D018319
has cross-reference: NCI:C3798
has cross-reference: SNOMEDCT_US_2020_03_01:134324009
has cross-reference: UMLS_CUI:C0751690
alternative_term: malignant neoplasm of the peripheral nerve Sheath
has_obo_namespace: disease_ontology
id: DOID:5940
in subset: NCIthesaurus

occlusion precerebral artery
type: Class
subclass of: cerebrovascular disease
imported from: doid.owl
has_alternative_id: DOID:10961
has_alternative_id: DOID:1547
has cross-reference: ICD10CM:I65.9
has cross-reference: ICD9CM:433.9
has cross-reference: UMLS_CUI:C0155727
has_obo_namespace: disease_ontology
has_related_synonym: Occlusion and stenosis of multiple and bilateral precerebral arteries
has_related_synonym: occlusion and stenosis of precerebral artery
id: DOID:5976

specific phobia
type: Class
subclass of: phobic disorder
textual definition: A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.
imported from: doid.owl
has cross-reference: ICD10CM:F40.2
has cross-reference: MESH:C562465
has cross-reference: NCI:C35284
has cross-reference: OMIM:608251
has cross-reference: SNOMEDCT_US_2020_03_01:54587008
has cross-reference: UMLS_CUI:C0236801
alternative_term: simple phobia
has_obo_namespace: disease_ontology
id: DOID:599
in subset: NCIthesaurus

congestive heart failure
type: Class
subclass of: heart disease
textual definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.
imported from: doid.owl
has_alternative_id: DOID:395
has cross-reference: ICD10CM:I50
has cross-reference: ICD10CM:I50.9
has cross-reference: ICD9CM:428
has cross-reference: ICD9CM:428.0
has cross-reference: MESH:D006333
has cross-reference: NCI:C3080
has cross-reference: NCI:C50577
has cross-reference: SNOMEDCT_US_2020_03_01:155374007
has cross-reference: SNOMEDCT_US_2020_03_01:195108009
has cross-reference: UMLS_CUI:C0018801
has cross-reference: UMLS_CUI:C0018802
alternative_term: CHF
alternative_term: Cardiac Failure Congestive
alternative_term: Congestive heart disease
alternative_term: Weak heart
has_obo_namespace: disease_ontology
id: DOID:6000
in subset: NCIthesaurus

appendix disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the appendix.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:60000

pulmonary artery disease
type: Class
subclass of: artery disease
subclass of: lung disease
textual definition: An artery disease that is located in the lungs.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:60001

malignant cystadenoma
type: Class
subclass of: malignant adenoma
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:60004

benign vascular tumor
type: Class
subclass of: cardiovascular organ benign neoplasm
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:60006

cerebrovascular benign neoplasm
type: Class
subclass of: cardiovascular organ benign neoplasm
textual definition: A cardiovascular organ benign neoplasm that is located_in the cerebrovascular system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:60007

parathyroid gland benign neoplasm
type: Class
subclass of: endocrine organ benign neoplasm
subclass of: parathyroid gland disease
textual definition: An endocrine organ benign neoplasm that is located_in some parathyroid gland.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:60008

pituitary gland benign neoplasm
type: Class
subclass of: endocrine organ benign neoplasm
subclass of: pituitary gland disease
textual definition: A benign neoplasm located in the pituitary gland.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:60009

selective immunoglobulin deficiency disease
type: Class
subclass of: B cell deficiency
textual definition: A B cell deficiency that is characterized by deficiency of an immunoglobulin subtype. The clinical course and prognosis is dependent upon the severity of the selective deficiency and associated morbidity.
imported from: doid.owl
has cross-reference: NCI:C27870
has cross-reference: UMLS_CUI:C1335942
has_obo_namespace: disease_ontology
id: DOID:6025
in subset: NCIthesaurus

juvenile type testicular granulosa cell tumor
type: Class
subclass of: testicular granulosa cell tumor
imported from: doid.owl
has_alternative_id: DOID:5332
has cross-reference: NCI:C39947
has cross-reference: NCI:C4207
has cross-reference: SNOMEDCT_US_2020_03_01:189735004
has cross-reference: UMLS_CUI:C0334403
has cross-reference: UMLS_CUI:C1515285
alternative_term: Juvenile granulosa cell tumor
alternative_term: Juvenile granulosa cell tumour
alternative_term: Juvenile type Granulosa cell tumor
alternative_term: Juvenile type Granulosa cell tumour
alternative_term: juvenile type granulosa cell neoplasm
alternative_term: juvenile type testicular granulosa cell tumour
has_obo_namespace: disease_ontology
id: DOID:6032
in subset: NCIthesaurus

esophageal disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the esophagus.
imported from: doid.owl
has_alternative_id: DOID:10117
has_alternative_id: DOID:10118
has_alternative_id: DOID:11798
has cross-reference: ICD10CM:K22.9
has cross-reference: ICD9CM:530.9
has cross-reference: MESH:D004935
has cross-reference: NCI:C3027
has cross-reference: SNOMEDCT_US_2020_03_01:266497000
has cross-reference: UMLS_CUI:C0014852
alternative_term: esophageal Ulcer
has_obo_namespace: disease_ontology
id: DOID:6050
in subset: NCIthesaurus

ovarian mucinous neoplasm
type: Class
subclass of: ovary epithelial cancer
textual definition: An ovary epithelial cancer that is characterized by the presence of mucin.
imported from: doid.owl
has_alternative_id: DOID:3712
has cross-reference: NCI:C40033
has cross-reference: NCI:C5242
has cross-reference: SNOMEDCT_US_2020_03_01:189683008
has cross-reference: UMLS_CUI:C1335168
has cross-reference: UMLS_CUI:C1518233
alternative_term: Ovarian mucinous tumor
alternative_term: malignant ovarian mucinous neoplasm
alternative_term: mucinous tumor of Ovary
has_obo_namespace: disease_ontology
id: DOID:6067
in subset: NCIthesaurus

paraplegia
type: Class
subclass of: central nervous system disease
imported from: doid.owl
has cross-reference: GARD:7327
has cross-reference: ICD10CM:G82.2
has cross-reference: ICD9CM:344.1
has cross-reference: MESH:D010264
has cross-reference: NCI:C50687
has cross-reference: SNOMEDCT_US_2020_03_01:155031004
has cross-reference: UMLS_CUI:C0030486
alternative_term: Paraplegia, lower
has_obo_namespace: disease_ontology
id: DOID:607
in subset: NCIthesaurus

acute stress disorder
type: Class
subclass of: anxiety disorder
textual definition: An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD.
imported from: doid.owl
has cross-reference: ICD9CM:308.3
has cross-reference: SNOMEDCT_US_2020_03_01:192043003
has cross-reference: UMLS_CUI:C0029488
alternative_term: traumatic stress disorder
has_obo_namespace: disease_ontology
id: DOID:6088

mitral valve disease
type: Class
subclass of: heart valve disease
imported from: doid.owl
has_alternative_id: DOID:11505
has_alternative_id: DOID:58
has_alternative_id: DOID:59
has cross-reference: ICD10CM:I05
has cross-reference: ICD10CM:I05.1
has cross-reference: ICD9CM:394
has cross-reference: ICD9CM:394.1
has cross-reference: ICD9CM:424.0
has cross-reference: NCI:C78446
has cross-reference: SNOMEDCT_US_2020_03_01:11851006
has cross-reference: SNOMEDCT_US_2020_03_01:155278007
has cross-reference: SNOMEDCT_US_2020_03_01:83898004
has cross-reference: UMLS_CUI:C0026265
has cross-reference: UMLS_CUI:C0155563
has cross-reference: UMLS_CUI:C0264765
alternative_term: Mitral RH valve dis.
alternative_term: Rheumatic disease of mitral valve
alternative_term: Rheumatic mitral insufficiency
alternative_term: Rheumatic mitral valve changes
alternative_term: Rheumatic mitral valve regurgitation
alternative_term: chronic rheumatic mitral valve
alternative_term: disease of mitral valve
alternative_term: rheumatic disease of mitral valve
alternative_term: rheumatic mitral valve incompetence
has_obo_namespace: disease_ontology
id: DOID:61
in subset: NCIthesaurus

jugular foramen meningioma
type: Class
subclass of: meningioma
imported from: doid.owl
has cross-reference: NCI:C5293
has cross-reference: UMLS_CUI:C1334298
alternative_term: meningioma of the Jugular Foramen
has_obo_namespace: disease_ontology
id: DOID:6110
in subset: NCIthesaurus

primary immunodeficiency disease
type: Class
subclass of: immune system disease
textual definition: An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.
imported from: doid.owl
has cross-reference: ICD10CM:D84.9
has cross-reference: ICD9CM:279.3
has cross-reference: KEGG:05340
has cross-reference: MESH:D007153
has cross-reference: NCI:C39725
has cross-reference: OMIM:242850
has cross-reference: OMIM:PS300755
has cross-reference: SNOMEDCT_US_2020_03_01:191005003
has cross-reference: UMLS_CUI:C0021051
alternative_term: hypoimmunity
alternative_term: immune deficiency disorder
alternative_term: immunodeficiency syndrome
has_obo_namespace: disease_ontology
id: DOID:612
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: Xref MGI.

anal canal carcinoma
type: Class
subclass of: anal canal cancer
subclass of: carcinoma
textual definition: An anal canal cancer that derives_from epithelial cells.
imported from: doid.owl
has cross-reference: MESH:C563020
has cross-reference: NCI:C7489
has cross-reference: OMIM:105580
has cross-reference: SNOMEDCT_US_2020_03_01:285310000
has cross-reference: UMLS_CUI:C0563211
alternative_term: anal canal and Perianal gland carcinoma
has_obo_namespace: disease_ontology
id: DOID:6126
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

bronchitis
type: Class
subclass of: bronchial disease
textual definition: A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.
imported from: doid.owl
has_alternative_id: DOID:13503
has_alternative_id: DOID:13504
has_alternative_id: DOID:13707
has_alternative_id: DOID:13728
has_alternative_id: DOID:13729
has_alternative_id: DOID:5049
has_alternative_id: DOID:6130
has_alternative_id: DOID:6131
has_alternative_id: DOID:9982
has_alternative_id: DOID:9983
has cross-reference: ICD10CM:J20
has cross-reference: ICD10CM:J40
has cross-reference: ICD10CM:J42
has cross-reference: ICD9CM:466.0
has cross-reference: ICD9CM:490
has cross-reference: ICD9CM:491
has cross-reference: MESH:D001991
has cross-reference: MESH:D029481
has cross-reference: NCI:C26722
has cross-reference: NCI:C26932
has cross-reference: NCI:C2911
has cross-reference: SNOMEDCT_US_2020_03_01:155512004
has cross-reference: SNOMEDCT_US_2020_03_01:155566007
has cross-reference: SNOMEDCT_US_2020_03_01:32398004
has cross-reference: UMLS_CUI:C0006277
has cross-reference: UMLS_CUI:C0008677
has cross-reference: UMLS_CUI:C0149514
alternative_term: CI - Chest infection
alternative_term: Chest infection
alternative_term: acute Bronchitis
alternative_term: chest cold
alternative_term: chronic bronchitis
alternative_term: recurrent wheezy bronchitis
has_obo_namespace: disease_ontology
has_related_synonym: acute bronchitis and bronchiolitis
id: DOID:6132
in subset: NCIthesaurus

lymphopenia
type: Class
subclass of: leukopenia
textual definition: A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood.
imported from: doid.owl
has cross-reference: ICD10CM:D72.810
has cross-reference: ICD9CM:288.51
has cross-reference: MESH:D008231
has cross-reference: SNOMEDCT_US_2020_03_01:48813009
has cross-reference: UMLS_CUI:C0024312
alternative_term: Lymphocytopenia
has_obo_namespace: disease_ontology
id: DOID:614

leukopenia
type: Class
subclass of: DOID 9500
textual definition: A leukocyte disorder that is characterized by a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.
imported from: doid.owl
has cross-reference: ICD10CM:D72.819
has cross-reference: ICD9CM:288.50
has cross-reference: MESH:D007970
has cross-reference: SNOMEDCT_US_2020_03_01:142917003
has cross-reference: UMLS_CUI:C0023530
alternative_term: Leucopenia
has_obo_namespace: disease_ontology
id: DOID:615

ovarian small cell carcinoma
type: Class
subclass of: ovarian carcinoma
textual definition: An ovarian carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.
imported from: doid.owl
has cross-reference: GARD:10411
has cross-reference: NCI:C27390
has_obo_namespace: disease_ontology
id: DOID:6179
in subset: NCIthesaurus

epithelioid sarcoma
type: Class
subclass of: sarcoma
subclass of: connective tissue cancer
textual definition: A connective tissue cancer that is characterized by the presence of epithelioid cells forming nodular patterns and has_material_basis_in mesenchymal tissue.
imported from: doid.owl
has cross-reference: GARD:10181
has cross-reference: MESH:D012509
has cross-reference: NCI:C3714
has cross-reference: SNOMEDCT_US_2020_03_01:782827000
has cross-reference: UMLS_CUI:C0205944
alternative_term: epithelioid cell sarcoma
has_obo_namespace: disease_ontology
id: DOID:6193
in subset: NCIthesaurus

conjunctivitis
type: Class
subclass of: conjunctival disease
textual definition: A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids.
imported from: doid.owl
has cross-reference: ICD10CM:H10
has cross-reference: ICD9CM:372.30
has cross-reference: MESH:D003231
has cross-reference: NCI:C34504
has cross-reference: SNOMEDCT_US_2020_03_01:193857008
has cross-reference: UMLS_CUI:C0009763
has_obo_namespace: disease_ontology
has_related_synonym: Madras eye
id: DOID:6195
in subset: NCIthesaurus

reactive arthritis
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: arthritis
textual definition: An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.
imported from: doid.owl
has_alternative_id: DOID:10148
has_alternative_id: DOID:11891
has_alternative_id: DOID:13318
has_alternative_id: DOID:13519
has_alternative_id: DOID:13782
has_alternative_id: DOID:13783
has_alternative_id: DOID:13784
has_alternative_id: DOID:13785
has_alternative_id: DOID:6194
has_alternative_id: DOID:9760
has cross-reference: GARD:5693
has cross-reference: ICD10CM:M02.10
has cross-reference: ICD10CM:M02.3
has cross-reference: ICD9CM:099.3
has cross-reference: ICD9CM:711.30
has cross-reference: MESH:D016918
has cross-reference: NCI:C34975
has cross-reference: SNOMEDCT_US_2020_03_01:266212009
has cross-reference: SNOMEDCT_US_2020_03_01:56528004
has cross-reference: UMLS_CUI:C0035012
has cross-reference: UMLS_CUI:C0152085
alternative_term: Fiessinger Leroy Reiter syndrome
alternative_term: Post-bacterial arthropathy
alternative_term: Reactive arthritis
alternative_term: Reiter disease
alternative_term: Reiter's disease
alternative_term: postdysenteric arthropathy
has_obo_namespace: disease_ontology
id: DOID:6196
in subset: NCIthesaurus

cornea cancer
type: Class
subclass of: corneal disease
subclass of: ocular cancer
imported from: doid.owl
has_alternative_id: DOID:12757
has cross-reference: ICD10CM:C69.1
has cross-reference: ICD9CM:190.4
has cross-reference: NCI:C3565
has cross-reference: NCI:C4361
has cross-reference: SNOMEDCT_US_2020_03_01:126997008
has cross-reference: SNOMEDCT_US_2020_03_01:93766000
has cross-reference: UMLS_CUI:C0153629
has cross-reference: UMLS_CUI:C0339304
alternative_term: Corneal tumor
alternative_term: malignant Corneal tumor
alternative_term: malignant neoplasm of cornea
alternative_term: malignant tumor of cornea
alternative_term: neoplasm of cornea
has_obo_namespace: disease_ontology
id: DOID:6199
in subset: NCIthesaurus

aortic valve disease
type: Class
subclass of: heart valve disease
subclass of: aortic disease
imported from: doid.owl
has_alternative_id: DOID:56
has cross-reference: ICD9CM:424.1
has cross-reference: NCI:C78650
has cross-reference: SNOMEDCT_US_2020_03_01:8722008
has cross-reference: UMLS_CUI:C1260873
has_obo_namespace: disease_ontology
id: DOID:62
in subset: NCIthesaurus
comment: Updating out dated UMLS CUI.

blood protein disease
type: Class
subclass of: hematopoietic system disease
imported from: doid.owl
has cross-reference: MESH:D001796
has cross-reference: UMLS_CUI:C0005830
alternative_term: blood protein disorder
has_obo_namespace: disease_ontology
id: DOID:620

pericardial mesothelioma
type: Class
subclass of: pericardium cancer
imported from: doid.owl
has_alternative_id: DOID:5883
has_alternative_id: DOID:7433
has cross-reference: ICD10CM:C45.2
has cross-reference: NCI:C7631
has cross-reference: NCI:C7632
has cross-reference: NCI:C8703
has cross-reference: SNOMEDCT_US_2020_03_01:187885008
has cross-reference: UMLS_CUI:C0346110
has cross-reference: UMLS_CUI:C0854883
has cross-reference: UMLS_CUI:C1335381
alternative_term: malignant Pericardial Mesothelioma
alternative_term: malignant mesothelioma of pericardium
has_obo_namespace: disease_ontology
id: DOID:6201
in subset: NCIthesaurus

follicular adenoma
type: Class
subclass of: thyroid adenoma
imported from: doid.owl
has cross-reference: MESH:D000236
has cross-reference: SNOMEDCT_US_2020_03_01:55021007
has cross-reference: UMLS_CUI:C0205647
alternative_term: Follicular adenoma
alternative_term: Follicular adenoma of the Thyroid gland
alternative_term: Thyroid follicular adenoma
has_obo_namespace: disease_ontology
id: DOID:6204

gastric diffuse adenocarcinoma
type: Class
subclass of: gastric adenocarcinoma
textual definition: A gastric adenocarcinoma that is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma.
imported from: doid.owl
has_alternative_id: DOID:4946
has cross-reference: NCI:C4127
has cross-reference: NCI:C9159
has cross-reference: SNOMEDCT_US_2020_03_01:24505004
has cross-reference: UMLS_CUI:C0279635
has cross-reference: UMLS_CUI:C0334280
has_obo_namespace: disease_ontology
id: DOID:6217
in subset: NCIthesaurus

articular cartilage disease
type: Class
subclass of: cartilage disease
imported from: doid.owl
has_alternative_id: DOID:6226
has_alternative_id: DOID:9366
has_alternative_id: DOID:9871
has_alternative_id: DOID:9872
has_alternative_id: DOID:9873
has_alternative_id: DOID:9874
has_alternative_id: DOID:9875
has cross-reference: ICD9CM:718.0
has cross-reference: SNOMEDCT_US_2020_03_01:268062001
has cross-reference: UMLS_CUI:C0158073
has_obo_namespace: disease_ontology
id: DOID:6227

non-invasive bladder papillary urothelial neoplasm
type: Class
subclass of: bladder papillary transitional cell neoplasm
imported from: doid.owl
has_alternative_id: DOID:6238
has cross-reference: NCI:C27884
has cross-reference: NCI:C39831
has cross-reference: SNOMEDCT_US_2020_03_01:128625004
has cross-reference: UMLS_CUI:C1266010
has cross-reference: UMLS_CUI:C1518358
alternative_term: Papillary urothelial neoplasm of low malignant potential
alternative_term: bladder PUNLMP
alternative_term: bladder papillary neoplasm of low malignant potential
has_obo_namespace: disease_ontology
id: DOID:6239
in subset: NCIthesaurus

renal oncocytoma
type: Class
subclass of: kidney benign neoplasm
imported from: doid.owl
has cross-reference: GARD:8477
has cross-reference: MESH:C537750
has cross-reference: NCI:C4526
has cross-reference: OMIM:553000
has cross-reference: SNOMEDCT_US_2020_03_01:254922006
has cross-reference: UMLS_CUI:C0346255
alternative_term: Oncocytoma of kidney
alternative_term: renal epithelial Oncocytic tumor
has_obo_namespace: disease_ontology
id: DOID:6245
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

transient hypogammaglobulinemia
type: Class
subclass of: agammaglobulinemia
imported from: doid.owl
has cross-reference: NCI:C27319
has cross-reference: UMLS_CUI:C0859960
has_obo_namespace: disease_ontology
id: DOID:625
in subset: NCIthesaurus

complement deficiency
type: Class
subclass of: primary immunodeficiency disease
textual definition: A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation.
imported from: doid.owl
has cross-reference: ICD10CM:D84.1
has cross-reference: MESH:D000081208
has cross-reference: NCI:C4691
has cross-reference: SNOMEDCT_US_2020_03_01:191014008
has cross-reference: UMLS_CUI:C0272242
alternative_term: Complement deficiency
alternative_term: Complement deficiency disease
has_obo_namespace: disease_ontology
id: DOID:626
in subset: NCIthesaurus

follicular dendritic cell sarcoma
type: Class
subclass of: dendritic cell sarcoma
textual definition: A dendritic cell sarcoma cancer that effects the follicular dendritic cells.
imported from: doid.owl
has cross-reference: ICD10CM:C96.4
has cross-reference: MESH:D054740
has cross-reference: NCI:C9281
has cross-reference: SNOMEDCT_US_2020_03_01:128816008
has cross-reference: UMLS_CUI:C1260325
alternative_term: Follicular Dendritic cell sarcoma
alternative_term: Follicular dendritic cell tumour
has_obo_namespace: disease_ontology
id: DOID:6262
in subset: NCIthesaurus

inflammatory breast carcinoma
type: Class
subclass of: breast adenocarcinoma
textual definition: A breast adenocarcinoma that is characterized by the clinical appearance of inflammation, with edema and redness of the breast due to pathologic plugging of the dermal lymphatics of the breast with tumor emboli.
imported from: doid.owl
has cross-reference: MESH:D058922
has cross-reference: NCI:C4001
has cross-reference: SNOMEDCT_US_2020_03_01:254840009
has cross-reference: UMLS_CUI:C0278601
alternative_term: Inflammatory carcinoma of breast
alternative_term: Mastitis carcinomatosa
has_obo_namespace: disease_ontology
id: DOID:6263
in subset: NCIthesaurus

severe combined immunodeficiency
type: Class
subclass of: combined immunodeficiency
textual definition: A combined T cell and B cell immunodeficiency that is caused by a defect in infection-fighting immune cells resulting in individuals with non-functional immune systems.
imported from: doid.owl
has cross-reference: GARD:7628
has cross-reference: MESH:D016511
has cross-reference: NCI:C3472
has cross-reference: SNOMEDCT_US_2020_03_01:190994004
has cross-reference: UMLS_CUI:C0085110
alternative_term: SCID
alternative_term: combined T and B cell inborn immunodeficiency
has_obo_namespace: disease_ontology
id: DOID:627
in subset: NCIthesaurus

gastric cardia carcinoma
type: Class
subclass of: cardia cancer
subclass of: stomach carcinoma
imported from: doid.owl
has cross-reference: NCI:C6794
has cross-reference: UMLS_CUI:C1333763
alternative_term: carcinoma of Cardia of stomach
has_obo_namespace: disease_ontology
id: DOID:6270
in subset: NCIthesaurus

gastric cardia adenocarcinoma
type: Class
subclass of: cardia cancer
subclass of: gastric adenocarcinoma
imported from: doid.owl
has cross-reference: NCI:C5247
has cross-reference: UMLS_CUI:C1333762
alternative_term: adenocarcinoma of Cardia of stomach
has_obo_namespace: disease_ontology
has_related_synonym: adenocarcinoma of gastric cardia
id: DOID:6271
in subset: NCIthesaurus

TSH producing pituitary tumor
type: Class
subclass of: functioning pituitary adenoma
imported from: doid.owl
has cross-reference: NCI:C8011
has cross-reference: SNOMEDCT_US_2020_03_01:254959007
has cross-reference: UMLS_CUI:C0346303
alternative_term: TSH Secreting adenoma of the Pituitary
alternative_term: TSH Secreting tumor of Pituitary
alternative_term: TSH Secreting tumour of Pituitary
alternative_term: TSH producing pituitary tumour
alternative_term: Thyrotroph adenoma
has_obo_namespace: disease_ontology
id: DOID:6275
in subset: NCIthesaurus

combined T cell and B cell immunodeficiency
type: Class
subclass of: combined immunodeficiency
textual definition: A primary immunodeficiency disease characterized by impaired T cell-mediated immunity and impaired B cell mediated humoral immunity.
imported from: doid.owl
has cross-reference: ICD10CM:D81
has cross-reference: ICD9CM:279.2
has cross-reference: NCI:C27871
has cross-reference: OMIM:312863
has cross-reference: ORDO:101972
has cross-reference: SNOMEDCT_US_2020_03_01:191003005
has cross-reference: UMLS_CUI:C0494261
alternative_term: Congenital Combined Immunodeficiency
alternative_term: combined immunodeficiency
has_obo_namespace: disease_ontology
id: DOID:628
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

genetic disease
type: Class
subclass of: disease
textual definition: A disease that has_material_basis_in genetic variations in the human genome.
imported from: doid.owl
has cross-reference: MESH:D030342
has cross-reference: NCI:C3101
has cross-reference: SNOMEDCT_US_2020_03_01:32895009
has cross-reference: UMLS_CUI:C0019247
has_obo_namespace: disease_ontology
id: DOID:630
in subset: NCIthesaurus

ectopic thymus
type: Class
subclass of: thymus gland disease
imported from: doid.owl
has cross-reference: NCI:C27804
has cross-reference: UMLS_CUI:C1333375
has_obo_namespace: disease_ontology
id: DOID:6307
in subset: NCIthesaurus

fibromyalgia
type: Class
subclass of: myositis
imported from: doid.owl
has cross-reference: ICD10CM:M79.7
has cross-reference: MESH:D005356
has cross-reference: NCI:C87497
has cross-reference: SNOMEDCT_US_2020_03_01:1304004
has cross-reference: UMLS_CUI:C0016053
has_obo_namespace: disease_ontology
id: DOID:631
in subset: NCIthesaurus

myositis
type: Class
subclass of: myopathy
textual definition: A myopathy characterized by muscle inflammation.
imported from: doid.owl
has cross-reference: ICD10CM:M60
has cross-reference: MESH:D009220
has cross-reference: NCI:C27578
has cross-reference: OMIM:160750
has cross-reference: SNOMEDCT_US_2020_03_01:26889001
has cross-reference: UMLS_CUI:C0027121
alternative_term: Inflammatory disorder of muscle
has_obo_namespace: disease_ontology
id: DOID:633
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

acquired immunodeficiency syndrome
type: Class
subclass of: human immunodeficiency virus infectious disease
textual definition: A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.
imported from: doid.owl
has cross-reference: EFO:0000765
has cross-reference: ICD10CM:B20
has cross-reference: MESH:D000163
has cross-reference: NCI:C2851
has cross-reference: SNOMEDCT_US_2020_03_01:62479008
has cross-reference: UMLS_CUI:C0001175
alternative_term: AIDS
alternative_term: acquired Immune deficiency
has_obo_namespace: disease_ontology
has_related_synonym: acquired immune deficiency syndrome
id: DOID:635
in subset: NCIthesaurus
in subset: zoonotic infectious disease

CLL/SLL
type: Class
subclass of: chronic lymphocytic leukemia
textual definition: A chronic lymphocytic leukemia that is characterized by the presence of immature lymphocytes in the blood and bone marrow and/or in the lymph nodes.
imported from: doid.owl
has cross-reference: NCI:C27911
has cross-reference: SNOMEDCT_US_2020_03_01:399607007
has cross-reference: UMLS_CUI:C1302547
alternative_term: chronic lymphocytic leukemia/small lymphocytic lymphoma
has_obo_namespace: disease_ontology
id: DOID:6354
in subset: DO cancer slim
in subset: NCIthesaurus

central pontine myelinolysis
type: Class
subclass of: demyelinating disease
textual definition: A demyelination disease that is characterized by severe damage to the myelin sheath of the pons' nerve cells and has_symptom acute paralysis, has_symptom dysphagia, and has_symptom dysarthria.
imported from: doid.owl
has cross-reference: GARD:8749
has cross-reference: ICD10CM:G37.2
has cross-reference: MESH:D017590
has cross-reference: NCI:C84623
has cross-reference: SNOMEDCT_US_2020_03_01:6807001
has cross-reference: UMLS_CUI:C0206083
alternative_term: osmotic demyelination syndrome
has_obo_namespace: disease_ontology
id: DOID:636
in subset: NCIthesaurus

migraine
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.
imported from: doid.owl
has_alternative_id: DOID:12437
has cross-reference: EFO:0003821
has cross-reference: ICD10CM:G43
has cross-reference: ICD9CM:346
has cross-reference: MESH:D008881
has cross-reference: NCI:C89715
has cross-reference: OMIM:157300
has cross-reference: SNOMEDCT_US_2020_03_01:155046006
has cross-reference: SNOMEDCT_US_2020_03_01:193036004
has cross-reference: UMLS_CUI:C0042331
has cross-reference: UMLS_CUI:C0149931
alternative_term: migraine disorder
alternative_term: migraine variant
alternative_term: migraine with or without aura
has_obo_namespace: disease_ontology
id: DOID:6364
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

acral lentiginous melanoma
type: Class
subclass of: DOID 8923
textual definition: A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.
imported from: doid.owl
has cross-reference: GARD:9570
alternative_term: acral lentiginous melanoma, malignant
alternative_term: malignant acral lentiginous melanoma
has_obo_namespace: disease_ontology
id: DOID:6367
in subset: DO cancer slim

hypersplenism
type: Class
subclass of: splenic disease
imported from: doid.owl
has cross-reference: ICD10CM:D73.1
has cross-reference: ICD9CM:289.4
has cross-reference: MESH:D006971
has cross-reference: NCI:C34714
has cross-reference: SNOMEDCT_US_2020_03_01:154839008
has cross-reference: UMLS_CUI:C0020532
alternative_term: hypersplenia
has_obo_namespace: disease_ontology
id: DOID:6376
in subset: NCIthesaurus

acute disseminated encephalomyelitis
type: Class
subclass of: encephalomyelitis
textual definition: An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.
imported from: doid.owl
has cross-reference: GARD:8639
has cross-reference: MESH:D004673
has cross-reference: NCI:C34578
has cross-reference: SNOMEDCT_US_2020_03_01:83942000
has cross-reference: UMLS_CUI:C0014059
alternative_term: ADEM
alternative_term: acute Disseminated Encephalomyelitis
alternative_term: acute disseminated encephalitis
has_obo_namespace: disease_ontology
id: DOID:639
in subset: NCIthesaurus

encephalomyelitis
type: Class
subclass of: central nervous system disease
imported from: doid.owl
has cross-reference: MESH:D004679
has cross-reference: NCI:C34580
has cross-reference: SNOMEDCT_US_2020_03_01:154991009
has cross-reference: UMLS_CUI:C0014070
alternative_term: Encephalitis &/or myelitis
has_obo_namespace: disease_ontology
id: DOID:640
in subset: NCIthesaurus

metanephric adenoma
type: Class
subclass of: renal adenoma
imported from: doid.owl
has cross-reference: NCI:C27253
has cross-reference: SNOMEDCT_US_2020_03_01:128670007
has cross-reference: UMLS_CUI:C1266045
alternative_term: Metanephric adenoma
has_obo_namespace: disease_ontology
id: DOID:6404
in subset: NCIthesaurus

double outlet right ventricle
type: Class
subclass of: ventricular septal defect
imported from: doid.owl
has cross-reference: GARD:1908
has cross-reference: ICD10CM:Q20.1
has cross-reference: ICD9CM:745.11
has cross-reference: MESH:D004310
has cross-reference: NCI:C98916
has cross-reference: OMIM:217095
has cross-reference: ORDO:3426
has cross-reference: SNOMEDCT_US_2020_03_01:7484005
has cross-reference: UMLS_CUI:C0013069
alternative_term: Dextrotransposition of aorta
alternative_term: Double outlet right ventricle
alternative_term: Double outlet right ventricle with subpulmonary ventricular septal defect
alternative_term: Taussig-Bing syndrome or defect
has_obo_namespace: disease_ontology
id: DOID:6406
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

tetralogy of Fallot
type: Class
subclass of: congenital heart disease
imported from: doid.owl
has cross-reference: GARD:2245
has cross-reference: ICD10CM:Q21.3
has cross-reference: ICD9CM:745.2
has cross-reference: MESH:D013771
has cross-reference: NCI:C84505
has cross-reference: OMIM:187500
has cross-reference: SNOMEDCT_US_2020_03_01:156913009
has cross-reference: UMLS_CUI:C0039685
alternative_term: Ventricular septal defect with pulmonary stenosis or atresia, dextraposition of aorta, and hypertrophy of right ventricle
has_obo_namespace: disease_ontology
id: DOID:6419
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

pulmonary valve stenosis
type: Class
subclass of: pulmonary valve disease
imported from: doid.owl
has cross-reference: GARD:4596
has cross-reference: MESH:D011666
has cross-reference: OMIM:265500
has cross-reference: SNOMEDCT_US_2020_03_01:56786000
has cross-reference: UMLS_CUI:C0034089
has_obo_namespace: disease_ontology
id: DOID:6420

eyelid carcinoma
type: Class
subclass of: skin carcinoma
subclass of: eyelid disease
imported from: doid.owl
has cross-reference: NCI:C6078
has cross-reference: UMLS_CUI:C0920196
alternative_term: carcinoma of the eyelid
has_obo_namespace: disease_ontology
id: DOID:6425
in subset: NCIthesaurus

progressive multifocal leukoencephalopathy
type: Class
subclass of: DOID 934
textual definition: A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.
imported from: doid.owl
has cross-reference: GARD:7468
has cross-reference: ICD10CM:A81.2
has cross-reference: ICD9CM:046.3
has cross-reference: MESH:D007968
has cross-reference: NCI:C26815
has cross-reference: SNOMEDCT_US_2020_03_01:22255007
has cross-reference: UMLS_CUI:C0023524
has_obo_namespace: disease_ontology
has_related_synonym: PML
id: DOID:643
in subset: NCIthesaurus

pulmonary hypertension
type: Class
subclass of: hypertension
textual definition: A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.
imported from: doid.owl
has cross-reference: ICD10CM:I27.20
has cross-reference: MESH:D006976
has cross-reference: NCI:C3120
has cross-reference: SNOMEDCT_US_2020_03_01:155328008
has cross-reference: UMLS_CUI:C0020542
has_obo_namespace: disease_ontology
id: DOID:6432
in subset: NCIthesaurus

Cowden syndrome
type: Class
subclass of: autosomal dominant disease
subclass of: syndrome
textual definition: A syndrome characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium.
imported from: doid.owl
has_alternative_id: DOID:3471
has cross-reference: GARD:6202
has cross-reference: MESH:D006223
has cross-reference: NCI:C3076
has cross-reference: NCI:C8419
has cross-reference: OMIM:PS158350
has cross-reference: ORDO:201
has cross-reference: SNOMEDCT_US_2020_03_01:58037000
has cross-reference: SNOMEDCT_US_2020_03_01:67944007
has cross-reference: UMLS_CUI:C0018553
has cross-reference: UMLS_CUI:C0391826
alternative_term: Cowden disease
alternative_term: Lhermitte-Duclos disease
alternative_term: dysplastic Gangliocytoma of Cerebellum
has_obo_namespace: disease_ontology
has_related_synonym: multiple hamartoma syndrome
id: DOID:6457
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

cerebellar liponeurocytoma
type: Class
subclass of: cerebellum cancer
imported from: doid.owl
has cross-reference: GARD:10642
has cross-reference: NCI:C6905
has cross-reference: SNOMEDCT_US_2020_03_01:734134003
has cross-reference: UMLS_CUI:C1370507
alternative_term: Cerebellar liponeurocytoma
alternative_term: Lipomatous Medulloblastoma
has_obo_namespace: disease_ontology
id: DOID:6458
in subset: NCIthesaurus

viral encephalitis
type: Class
subclass of: DOID 934
subclass of: DOID 9588
textual definition: An encephalitis that involves inflammation of the brain caused by viral infection.
imported from: doid.owl
has_alternative_id: DOID:10248
has_alternative_id: DOID:10249
has_alternative_id: DOID:10839
has cross-reference: MESH:D004671
has cross-reference: NCI:C34576
has cross-reference: SNOMEDCT_US_2020_03_01:68197003
has cross-reference: UMLS_CUI:C0014055
alternative_term: epidemic encephalitis
has_obo_namespace: disease_ontology
id: DOID:646
in subset: NCIthesaurus

large intestine lipoma
type: Class
subclass of: lipoma
subclass of: intestinal benign neoplasm
textual definition: An intestinal benign neoplasm that derives_from fat cells and that is located_in the large intestine.
imported from: doid.owl
has cross-reference: NCI:C5678
has cross-reference: UMLS_CUI:C1333114
alternative_term: Lipoma of large Intestine
has_obo_namespace: disease_ontology
id: DOID:6460
in subset: NCIthesaurus

ovarian mucinous adenofibroma
type: Class
subclass of: ovarian benign neoplasm
textual definition: An ovarian benign neoplasm that is characterized by low beta-hCG levels and is has_material_basis_in glandular and fibrous tissues, with a relatively large proportion of glands.
imported from: doid.owl
has cross-reference: NCI:C40040
has cross-reference: UMLS_CUI:C1518723
has_obo_namespace: disease_ontology
id: DOID:6469
in subset: NCIthesaurus

kuru
type: Class
subclass of: prion disease
imported from: doid.owl
has cross-reference: GARD:7617
has cross-reference: ICD10CM:A81.81
has cross-reference: ICD9CM:046.0
has cross-reference: MESH:D007729
has cross-reference: SNOMEDCT_US_2020_03_01:192684001
has cross-reference: UMLS_CUI:C0022802
alternative_term: kuru encephalopathy
has_obo_namespace: disease_ontology
id: DOID:648

prion disease
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins.
imported from: doid.owl
has cross-reference: ICD10CM:A81.9
has cross-reference: KEGG:05020
has cross-reference: MESH:D017096
has cross-reference: NCI:C128346
has cross-reference: SNOMEDCT_US_2020_03_01:20484008
has cross-reference: UMLS_CUI:C0162534
alternative_term: Prion disease pathway
alternative_term: Prion protein disease
alternative_term: Spongiform Encephalopathy
alternative_term: prion induced disorder
alternative_term: transmissible spongiform encephalopathy
has_obo_namespace: disease_ontology
id: DOID:649
in subset: DO FlyBase slim
in subset: NCIthesaurus

extraskeletal myxoid chondrosarcoma
type: Class
subclass of: extraosseous chondrosarcoma
textual definition: An extraosseous chondrosarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage and is characterized by a marked abundance of extracellular mucoid (myxoid) matrix.
imported from: doid.owl
has cross-reference: MESH:C563195
has cross-reference: NCI:C27502
has cross-reference: OMIM:612237
has cross-reference: SNOMEDCT_US_2020_03_01:404079008
has cross-reference: UMLS_CUI:C1275278
alternative_term: Myxoid extraosseous chondrosarcoma
has_obo_namespace: disease_ontology
id: DOID:6496
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

seborrheic keratosis
type: Class
subclass of: keratosis
subclass of: acanthoma
subclass of: skin benign neoplasm
imported from: doid.owl
has cross-reference: GARD:3108
has cross-reference: ICD10CM:L82
has cross-reference: ICD9CM:702.1
has cross-reference: MESH:D017492
has cross-reference: NCI:C9006
has cross-reference: OMIM:182000
has cross-reference: SNOMEDCT_US_2020_03_01:201096007
has cross-reference: UMLS_CUI:C0022603
has_obo_namespace: disease_ontology
id: DOID:6498
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

connective tissue disease
type: Class
subclass of: musculoskeletal system disease
textual definition: A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage.
imported from: doid.owl
has cross-reference: MESH:D003240
has cross-reference: NCI:C26729
has cross-reference: SNOMEDCT_US_2020_03_01:201432001
has cross-reference: UMLS_CUI:C0009782
alternative_term: connective tissue disorder
alternative_term: disorder of connective tissue
has_obo_namespace: disease_ontology
id: DOID:65
in subset: NCIthesaurus

purine-pyrimidine metabolic disorder
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism.
imported from: doid.owl
has cross-reference: ICD10CM:E79.8
has cross-reference: ICD9CM:277.2
has cross-reference: SNOMEDCT_US_2020_03_01:190917005
has cross-reference: UMLS_CUI:C0029595
alternative_term: inborn errors of purine-pyrimidine metabolism
has_obo_namespace: disease_ontology
id: DOID:653

cortical thymoma
type: Class
subclass of: dendritic cell thymoma
imported from: doid.owl
has cross-reference: NCI:C6888
has cross-reference: SNOMEDCT_US_2020_03_01:128713007
has cross-reference: UMLS_CUI:C1266095
alternative_term: Polygonal cell Thymoma
alternative_term: Thymoma, cortical
has_obo_namespace: disease_ontology
id: DOID:6530
in subset: NCIthesaurus

plasma cell neoplasm
type: Class
subclass of: mature B-cell neoplasm
textual definition: A mature B-cell neoplasm that is composed of plasma cells.
imported from: doid.owl
has cross-reference: EFO:0000200
has cross-reference: MESH:D010265
has cross-reference: SNOMEDCT_US_2020_03_01:71390001
has cross-reference: UMLS_CUI:C1136084
alternative_term: Plasma cell dyscrasia
alternative_term: Plasma cell tumour
alternative_term: Plasmacytic tumor
has_obo_namespace: disease_ontology
id: DOID:6536

overnutrition
type: Class
subclass of: nutrition disease
textual definition: A nutrition disease that is characterized by an excess of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content.
imported from: doid.owl
has cross-reference: MESH:D044343
has cross-reference: SNOMEDCT_US_2020_03_01:302872003
has cross-reference: UMLS_CUI:C1257763
has_obo_namespace: disease_ontology
id: DOID:654
comment: Updated outdated UMLS CUI.

acne
type: Class
subclass of: DOID 9098
textual definition: A sebaceous gland disease characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring.
imported from: doid.owl
has_alternative_id: DOID:9906
has cross-reference: ICD10CM:L70
has cross-reference: ICD10CM:L70.2
has cross-reference: ICD9CM:706.0
has cross-reference: MESH:D000152
has cross-reference: OMIM:604324
has cross-reference: SNOMEDCT_US_2020_03_01:11381005
has cross-reference: SNOMEDCT_US_2020_03_01:201210008
has cross-reference: UMLS_CUI:C0152249
has cross-reference: UMLS_CUI:C0702166
alternative_term: Acne varioliformis
alternative_term: acne vulgaris
alternative_term: frontalis acne
has_obo_namespace: disease_ontology
id: DOID:6543

heart lymphoma
type: Class
subclass of: lymphoma
subclass of: heart cancer
imported from: doid.owl
has cross-reference: NCI:C5368
has cross-reference: UMLS_CUI:C1332850
alternative_term: Lymphoma of Heart
has_obo_namespace: disease_ontology
id: DOID:6547
in subset: NCIthesaurus

inherited metabolic disorder
type: Class
subclass of: disease of metabolism
textual definition: A disease of metabolism that is characterized by enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality.
imported from: doid.owl
has cross-reference: MESH:D008661
has cross-reference: NCI:C34816
has cross-reference: SNOMEDCT_US_2020_03_01:86095007
has cross-reference: UMLS_CUI:C0025521
alternative_term: Inborn Errors of Metabolism
alternative_term: Metabolic hereditary disorder
alternative_term: inborn metabolism disorder
has_obo_namespace: disease_ontology
id: DOID:655
in subset: DO MGI slim
in subset: NCIthesaurus

adrenal adenoma
type: Class
subclass of: endocrine organ benign neoplasm
subclass of: adenoma
subclass of: DOID 9553
textual definition: An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.
imported from: doid.owl
has cross-reference: GARD:5745
alternative_term: adenoma of the Adrenal gland
has_obo_namespace: disease_ontology
id: DOID:656

adenoma
type: Class
subclass of: cell type benign neoplasm
textual definition: A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.
imported from: doid.owl
has_alternative_id: DOID:2655
has cross-reference: MESH:D000236
has cross-reference: NCI:C2855
has cross-reference: NCI:C4196
has cross-reference: SNOMEDCT_US_2020_03_01:443416007
has cross-reference: SNOMEDCT_US_2020_03_01:79041005
has cross-reference: UMLS_CUI:C0001430
has cross-reference: UMLS_CUI:C0334389
alternative_term: acinar cell adenoma
alternative_term: acinic cell adenoma
alternative_term: adenomas
has_obo_namespace: disease_ontology
id: DOID:657
in subset: NCIthesaurus

muscle tissue disease
type: Class
subclass of: muscular disease
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:66

adrenal cortex cancer
type: Class
subclass of: adrenal cortex disease
subclass of: adrenal gland cancer
imported from: doid.owl
has_alternative_id: DOID:3949
has cross-reference: ICD10CM:C74.0
has cross-reference: MESH:D000306
has cross-reference: NCI:C2858
has cross-reference: NCI:C9327
has cross-reference: SNOMEDCT_US_2020_03_01:127022002
has cross-reference: SNOMEDCT_US_2020_03_01:93664009
has cross-reference: UMLS_CUI:C0001618
has cross-reference: UMLS_CUI:C0346402
alternative_term: Adrenal cortical tumors
alternative_term: malignant Adrenocortical tumor
alternative_term: malignant neoplasm of adrenal cortex
alternative_term: malignant tumour of adrenal cortex
alternative_term: neoplasm of adrenal cortex
has_obo_namespace: disease_ontology
id: DOID:660
in subset: NCIthesaurus

leukocyte adhesion deficiency
type: Class
subclass of: autosomal recessive disease
subclass of: combined T cell and B cell immunodeficiency
subclass of: DOID 9500
textual definition: A combined T cell and B cell immunodeficiency that is characterized by defects affecting how white blood cells respond and travel to the site of a wound or infection affecting the immune system.
imported from: doid.owl
has_alternative_id: DOID:611
has cross-reference: GARD:9544
has cross-reference: MESH:D018370
has cross-reference: ORDO:2968
has cross-reference: UMLS_CUI:C0242597
alternative_term: Congenital leukocyte adherence deficiency
has_obo_namespace: disease_ontology
id: DOID:6612

X-linked hyper IgM syndrome
type: Class
subclass of: X-linked recessive disease
subclass of: hyper IgM syndrome
textual definition: A hyper IgM syndrome that is characterized by neutropenia and a high rate of gastrointestinal and central nervous system infections and that has_material_basis_in a mutation in the CD40LG gene (300386) on chromosome Xq26.
imported from: doid.owl
has cross-reference: GARD:73
has cross-reference: MESH:D053306
has cross-reference: NCI:C3990
has cross-reference: SNOMEDCT_US_2020_03_01:82286005
has cross-reference: UMLS_CUI:C0272236
alternative_term: hyperimmunoglobulin M syndrome
has_obo_namespace: disease_ontology
id: DOID:6620
in subset: NCIthesaurus

cerebral angioma
type: Class
subclass of: brain angioma
textual definition: A brain angioma that is characterized by vascular abnormalities that develops from cranial and spinal blood vasculature, has_material_basis_in abnormally proliferating cells, derives_from endothelial cells in and about the vascular lumen.
imported from: doid.owl
has cross-reference: NCI:C5433
has cross-reference: UMLS_CUI:C0877388
alternative_term: hemangioma of Cerebrum
has_obo_namespace: disease_ontology
id: DOID:6621
in subset: NCIthesaurus

diffuse idiopathic skeletal hyperostosis
type: Class
subclass of: spinal disease
subclass of: calcinosis
textual definition: A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine.
imported from: doid.owl
has cross-reference: GARD:6460
has cross-reference: ICD10CM:M48.1
has cross-reference: ICD9CM:721.6
has cross-reference: MESH:D004057
has cross-reference: NCI:C84671
has cross-reference: OMIM:106400
has cross-reference: SNOMEDCT_US_2020_03_01:31487001
has cross-reference: UMLS_CUI:C0020498
alternative_term: Ankylosing vertebral hyperostosis
alternative_term: DISH
alternative_term: Disseminated idiopathic skeletal hyperostosis
has_obo_namespace: disease_ontology
has_related_synonym: Forestier disease
id: DOID:6652
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

pulmonary large cell neuroendocrine carcinoma
type: Class
subclass of: lung large cell carcinoma
imported from: doid.owl
has_alternative_id: DOID:5721
has cross-reference: NCI:C5672
has cross-reference: NCI:C6875
has cross-reference: SNOMEDCT_US_2020_03_01:128628002
has cross-reference: UMLS_CUI:C1265996
has cross-reference: UMLS_CUI:C1334363
has_obo_namespace: disease_ontology
id: DOID:6658
in subset: NCIthesaurus

tooth and nail syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.
imported from: doid.owl
has cross-reference: MESH:C536736
has cross-reference: NCI:C40553
has cross-reference: OMIM:189500
has cross-reference: SNOMEDCT_US_2020_03_01:400036004
has cross-reference: UMLS_CUI:C0406735
alternative_term: Hypoplastic enamel-onycholysis-hypohidrosis syndrome
alternative_term: Tooth and Nail syndrome
alternative_term: Witkop's syndrome
has_obo_namespace: disease_ontology
id: DOID:6678
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

myositis ossificans
type: Class
subclass of: myositis
textual definition: A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.
imported from: doid.owl
has cross-reference: MESH:D009221
has cross-reference: NCI:C3253
has cross-reference: SNOMEDCT_US_2020_03_01:44551007
has cross-reference: UMLS_CUI:C0027122
alternative_term: Myisitis ossificans
alternative_term: Ossification - muscle
has_obo_namespace: disease_ontology
id: DOID:668
in subset: NCIthesaurus

Capgras syndrome
type: Class
subclass of: delusional disorder
textual definition: A delusional disorder in which a person holds a delusion that a friend, spouse, parent, or other close family member has been replaced by an identical-looking impostor.
imported from: doid.owl
has cross-reference: MESH:D002194
has cross-reference: NCI:C34446
has cross-reference: SNOMEDCT_US_2020_03_01:44906001
has cross-reference: UMLS_CUI:C0006895
alternative_term: Capgras delusion theory
has_obo_namespace: disease_ontology
id: DOID:6680
in subset: NCIthesaurus

spondylolisthesis
type: Class
subclass of: bone structure disease
textual definition: A bone structure disease that has_material_basis_in displacement located_in set of vertebrae.
imported from: doid.owl
has cross-reference: ICD10CM:M43.1
has cross-reference: MESH:D013168
has cross-reference: NCI:C35033
has cross-reference: OMIM:184200
has cross-reference: SNOMEDCT_US_2020_03_01:157003009
has cross-reference: UMLS_CUI:C0038016
has_obo_namespace: disease_ontology
id: DOID:6682
in subset: NCIthesaurus

X-linked Aarskog syndrome
type: Class
subclass of: X-linked recessive disease
subclass of: Aarskog syndrome
textual definition: A syndromic X-linked intellectual disability affects a person's height, muscles, skeleton, genitals, and appearance of the face.
imported from: doid.owl
has cross-reference: GARD:4775
has cross-reference: ICD10CM:Q87.19
has cross-reference: MESH:C535331
has cross-reference: NCI:C129720
has cross-reference: OMIM:305400
has cross-reference: SNOMEDCT_US_2020_03_01:205809002
has cross-reference: UMLS_CUI:C0175701
alternative_term: Aarskog-Scott syndrome
alternative_term: Greig's syndrome
alternative_term: faciogenital dysplasia
has_obo_namespace: disease_ontology
id: DOID:6683
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

autoimmune lymphoproliferative syndrome
type: Class
subclass of: hypersensitivity reaction type IV disease
textual definition: A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.
imported from: doid.owl
has cross-reference: GARD:8686
has cross-reference: ICD10CM:D89.82
has cross-reference: ICD9CM:279.41
has cross-reference: MESH:D056735
has cross-reference: NCI:C37864
has cross-reference: OMIM:601859
has cross-reference: ORDO:3261
has cross-reference: SNOMEDCT_US_2020_03_01:702444009
has cross-reference: UMLS_CUI:C1328840
alternative_term: ALPS
alternative_term: Canale-Smith syndrome
has_obo_namespace: disease_ontology
id: DOID:6688
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

malignant triton tumor
type: Class
subclass of: malignant peripheral nerve sheath tumor
imported from: doid.owl
has cross-reference: NCI:C4335
has cross-reference: SNOMEDCT_US_2020_03_01:354002
has cross-reference: UMLS_CUI:C0334616
alternative_term: MPNST with Rhabdomyosarcoma
alternative_term: MPNST with rhabdomyoblastic differentiation
alternative_term: malignant Triton tumor
alternative_term: malignant Triton tumour
alternative_term: malignant peripheral nerve sheath neoplasm with rhabdomyosarcoma
has_obo_namespace: disease_ontology
id: DOID:6707
in subset: NCIthesaurus

anterior spinal artery syndrome
type: Class
subclass of: artery disease
subclass of: syndrome
subclass of: cerebrovascular disease
textual definition: A syndrome that is characterized by loss of function of the anterior two-thirds of the spinal cord that results from ischemia of the anterior spinal artery.
imported from: doid.owl
has cross-reference: GARD:9653
has cross-reference: ICD10CM:G83.82
has cross-reference: MESH:D020759
has cross-reference: SNOMEDCT_US_2020_03_01:282785008
has cross-reference: UMLS_CUI:C0221069
alternative_term: Anterior spinal artery occlusion syndrome
has_obo_namespace: disease_ontology
id: DOID:6712

cerebrovascular disease
type: Class
subclass of: vascular disease
subclass of: DOID 936
textual definition: An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain.
imported from: doid.owl
has_alternative_id: DOID:12214
has_alternative_id: DOID:3455
has_alternative_id: DOID:8231
has cross-reference: EFO:0000712
has cross-reference: ICD10CM:I67.9
has cross-reference: ICD9CM:437.9
has cross-reference: MESH:D002561
has cross-reference: NCI:C2938
has cross-reference: SNOMEDCT_US_2020_03_01:266312006
has cross-reference: UMLS_CUI:C0007820
alternative_term: CVA
alternative_term: Cerebrovascular accident
alternative_term: cerebrovascular accident
alternative_term: cerebrovascular disorder
alternative_term: stroke
has_obo_namespace: disease_ontology
id: DOID:6713
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

spleen cancer
type: Class
subclass of: lymphatic system cancer
subclass of: splenic disease
textual definition: A lymphatic system cancer that affects white blood cells and involves tumor deposits in the spleen.
imported from: doid.owl
has_alternative_id: DOID:671
has cross-reference: GARD:7683
has cross-reference: ICD10CM:C26.1
has cross-reference: MESH:D013160
has cross-reference: NCI:C3383
has cross-reference: NCI:C3539
has cross-reference: SNOMEDCT_US_2020_03_01:127230005
has cross-reference: SNOMEDCT_US_2020_03_01:94071006
has cross-reference: UMLS_CUI:C0037999
has cross-reference: UMLS_CUI:C0153470
alternative_term: Splenic neoplasm
alternative_term: malignant Splenic tumor
alternative_term: malignant tumour of spleen
alternative_term: spleen neoplasm
has_obo_namespace: disease_ontology
id: DOID:672
in subset: NCIthesaurus

spinal stenosis
type: Class
subclass of: bone deterioration disease
textual definition: A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord.
imported from: doid.owl
has_alternative_id: DOID:10097
has_alternative_id: DOID:12235
has cross-reference: ICD10CM:M48.0
has cross-reference: ICD10CM:M48.02
has cross-reference: ICD10CM:M48.061
has cross-reference: ICD9CM:723.0
has cross-reference: ICD9CM:724.00
has cross-reference: MESH:D013130
has cross-reference: SNOMEDCT_US_2020_03_01:18347007
has cross-reference: SNOMEDCT_US_2020_03_01:268082002
has cross-reference: SNOMEDCT_US_2020_03_01:83561009
has cross-reference: UMLS_CUI:C0037944
has cross-reference: UMLS_CUI:C0158280
has cross-reference: UMLS_CUI:C0158288
alternative_term: Spinal stenosis of lumbar region
alternative_term: cervical spinal stenosis
alternative_term: lumbar spinal stenosis
has_obo_namespace: disease_ontology
id: DOID:6725

cleft palate
type: Class
subclass of: orofacial cleft
textual definition: An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.
imported from: doid.owl
has cross-reference: ICD10CM:Q35
has cross-reference: ICD9CM:749.0
has cross-reference: MESH:D002972
has cross-reference: NCI:C87069
has cross-reference: ORDO:99772
has cross-reference: SNOMEDCT_US_2020_03_01:156940009
has cross-reference: UMLS_CUI:C0008925
alternative_term: Palatoschisis
has_obo_namespace: disease_ontology
id: DOID:674
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cervix small cell carcinoma
type: Class
subclass of: cervix carcinoma
imported from: doid.owl
has cross-reference: NCI:C7982
has cross-reference: UMLS_CUI:C0279674
alternative_term: small cell carcinoma of the Cervix Uteri
has_obo_namespace: disease_ontology
has_related_synonym: small cell carcinoma of the cervix
id: DOID:6740
in subset: NCIthesaurus

juvenile rheumatoid arthritis
type: Class
subclass of: rheumatoid arthritis
textual definition: A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.
imported from: doid.owl
has_alternative_id: DOID:10129
has_alternative_id: DOID:1264
has_alternative_id: DOID:675
has cross-reference: GARD:3067
has cross-reference: ICD10CM:M08.4
has cross-reference: ICD9CM:714.3
has cross-reference: ICD9CM:714.31
has cross-reference: ICD9CM:714.32
has cross-reference: ICD9CM:714.33
has cross-reference: NCI:C26979
has cross-reference: NCI:C61279
has cross-reference: OMIM:604302
has cross-reference: ORDO:92
has cross-reference: SNOMEDCT_US_2020_03_01:201798003
has cross-reference: SNOMEDCT_US_2020_03_01:201799006
has cross-reference: SNOMEDCT_US_2020_03_01:74391003
has cross-reference: SNOMEDCT_US_2020_03_01:7441009
has cross-reference: UMLS_CUI:C0157916
has cross-reference: UMLS_CUI:C0157917
has cross-reference: UMLS_CUI:C0157918
has cross-reference: UMLS_CUI:C0409667
alternative_term: Pauciarticular onset juvenile chronic arthritis
alternative_term: Still's disease
alternative_term: acute juvenile rheumatoid arthritis
alternative_term: juvenile chronic polyarthritis
alternative_term: juvenile idiopathic arthritis
alternative_term: monarticular juvenile rheumatoid arthritis
alternative_term: pauciarticular juvenile arthritis
alternative_term: systemic juvenile rheumatoid arthritis
has_obo_namespace: disease_ontology
id: DOID:676
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

lung lymphoma
type: Class
subclass of: lymphoma
subclass of: lung cancer
imported from: doid.owl
has cross-reference: UMLS_CUI:C0519063
alternative_term: lymphoma of lung
alternative_term: pulmonary Lymphoma
has_obo_namespace: disease_ontology
id: DOID:6760

progressive supranuclear palsy
type: Class
subclass of: movement disease
textual definition: A movement disease that is characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain.
imported from: doid.owl
has cross-reference: GARD:7471
has cross-reference: ICD10CM:G23.1
has cross-reference: MESH:D013494
has cross-reference: NCI:C85028
has cross-reference: OMIM:601104
has cross-reference: OMIM:609454
has cross-reference: OMIM:610898
has cross-reference: ORDO:683
has cross-reference: SNOMEDCT_US_2020_03_01:192975003
has cross-reference: UMLS_CUI:C0038868
alternative_term: Steele-Richardson-Olszewski syndrome
alternative_term: progressive supranuclear ophthalmoplegia
has_obo_namespace: disease_ontology
id: DOID:678
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

basal ganglia disease
type: Class
subclass of: DOID 936
textual definition: A brain disease that is characterized by dysfunctional movement, located_in basal ganglia with_material_basis_in diseased components of the basal ganglia and associated neural circuits.
imported from: doid.owl
has cross-reference: MESH:D001480
has cross-reference: SNOMEDCT_US_2020_03_01:70835005
has cross-reference: UMLS_CUI:C0004782
has_obo_namespace: disease_ontology
id: DOID:679

tauopathy
type: Class
subclass of: neurodegenerative disease
textual definition: A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.
imported from: doid.owl
has cross-reference: MESH:D024801
has cross-reference: UMLS_CUI:C0949664
has_obo_namespace: disease_ontology
id: DOID:680
in subset: DO FlyBase slim

progressive bulbar palsy
type: Class
subclass of: motor neuron disease
imported from: doid.owl
has cross-reference: GARD:10928
has cross-reference: ICD10CM:G12.22
has cross-reference: ICD9CM:335.22
has cross-reference: MESH:D010244
has cross-reference: NCI:C85026
has cross-reference: SNOMEDCT_US_2020_03_01:54304004
has cross-reference: UMLS_CUI:C0030442
has_obo_namespace: disease_ontology
id: DOID:681
in subset: NCIthesaurus

juvenile pilocytic astrocytoma
type: Class
subclass of: pilocytic astrocytoma
textual definition: A pilocytic astrocytoma that occurs during adolescence.
imported from: doid.owl
has cross-reference: MESH:D001254
has cross-reference: NCI:C27081
has cross-reference: UMLS_CUI:C0280783
has_obo_namespace: disease_ontology
id: DOID:6811
in subset: NCIthesaurus

hepatocellular carcinoma
type: Class
subclass of: liver carcinoma
textual definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
imported from: doid.owl
has_alternative_id: DOID:5005
has cross-reference: EFO:0000182
has cross-reference: ICD10CM:C22.0
has cross-reference: ICDO:M8170/3
has cross-reference: NCI:C3099
has cross-reference: OMIM:114550
has cross-reference: ORDO:88673
has cross-reference: SNOMEDCT_US_2019_09_01:109841003
alternative_term: Hepatoma
has_obo_namespace: disease_ontology
id: DOID:684
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

familial melanoma
type: Class
subclass of: melanoma
imported from: doid.owl
has cross-reference: NCI:C8498
has cross-reference: UMLS_CUI:C1512419
has_obo_namespace: disease_ontology
id: DOID:6846
in subset: NCIthesaurus

liver carcinoma
type: Class
subclass of: carcinoma
subclass of: liver cancer
textual definition: A liver cancer that has_material_basis_in epithelial cells.
imported from: doid.owl
has cross-reference: NCI:C7927
has cross-reference: UMLS_CUI:C0279000
alternative_term: Liver and Intrahepatic bile duct carcinoma
has_obo_namespace: disease_ontology
id: DOID:686
in subset: NCIthesaurus

hepatoblastoma
type: Class
subclass of: liver cancer
imported from: doid.owl
has cross-reference: GARD:2657
has cross-reference: ICD10CM:C22.2
has cross-reference: ICDO:M8970/3
has cross-reference: MESH:D018197
has cross-reference: NCI:C3728
has cross-reference: SNOMEDCT_US_2020_03_01:109843000
has cross-reference: UMLS_CUI:C0206624
has_obo_namespace: disease_ontology
id: DOID:687
in subset: DO cancer slim
in subset: NCIthesaurus

embryonal cancer
type: Class
subclass of: germ cell cancer
textual definition: A germ cell cancer that is associated with an embryo.
imported from: doid.owl
has cross-reference: MESH:D009373
has cross-reference: NCI:C3264
has cross-reference: UMLS_CUI:C0027654
alternative_term: embryo neoplasm
alternative_term: embryonal neoplasm
has_obo_namespace: disease_ontology
id: DOID:688
in subset: NCIthesaurus

eye lymphoma
type: Class
subclass of: lymphoma
subclass of: ocular cancer
textual definition: A lymphoma by site that is manifested in immune system cells called lymphocytes.
imported from: doid.owl
has cross-reference: NCI:C35690
has cross-reference: UMLS_CUI:C1333519
has_obo_namespace: disease_ontology
id: DOID:6903
in subset: NCIthesaurus

peroneal nerve paralysis
type: Class
subclass of: peripheral nervous system disease
imported from: doid.owl
has cross-reference: ICD10CM:G57.3
has cross-reference: MESH:D020427
has cross-reference: NCI:C27061
has cross-reference: SNOMEDCT_US_2020_03_01:34553007
has cross-reference: UMLS_CUI:C0270810
alternative_term: Peroneal nerve palsy
has_obo_namespace: disease_ontology
id: DOID:6925
in subset: NCIthesaurus

retinal edema
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: ICD10CM:H35.81
has cross-reference: ICD9CM:362.83
has cross-reference: MESH:D010211
has cross-reference: SNOMEDCT_US_2020_03_01:6141006
has cross-reference: UMLS_CUI:C0242420
has_obo_namespace: disease_ontology
id: DOID:6929

dental enamel hypoplasia
type: Class
subclass of: teeth hard tissue disease
imported from: doid.owl
has cross-reference: MESH:D003744
has cross-reference: NCI:C34529
has cross-reference: SNOMEDCT_US_2020_03_01:699382004
has cross-reference: UMLS_CUI:C0011351
alternative_term: Enamel Hypoplasia
alternative_term: Enamel hypoplasia
has_obo_namespace: disease_ontology
id: DOID:693
in subset: NCIthesaurus

bladder transitional cell papilloma
type: Class
subclass of: bladder papillary transitional cell neoplasm
imported from: doid.owl
has_alternative_id: DOID:2141
has cross-reference: NCI:C3842
has cross-reference: NCI:C39858
has cross-reference: SNOMEDCT_US_2020_03_01:189459005
has cross-reference: SNOMEDCT_US_2020_03_01:45083001
has cross-reference: UMLS_CUI:C0235754
has cross-reference: UMLS_CUI:C1384678
alternative_term: Urothelial papilloma
alternative_term: bladder papilloma
alternative_term: transitional cell papilloma of bladder
alternative_term: urinary bladder Urothelial papilloma
has_obo_namespace: disease_ontology
id: DOID:6933
in subset: NCIthesaurus

telangiectatic osteogenic sarcoma
type: Class
subclass of: conventional central osteosarcoma
imported from: doid.owl
has cross-reference: NCI:C3902
has cross-reference: SNOMEDCT_US_2020_03_01:78453009
has cross-reference: UMLS_CUI:C0259782
alternative_term: Telangiectatic osteosarcoma
has_obo_namespace: disease_ontology
id: DOID:6951
in subset: NCIthesaurus

acute inflammation of lacrimal passage
type: Class
subclass of: lacrimal apparatus disease
imported from: doid.owl
has cross-reference: ICD10CM:H04.3
has cross-reference: ICD9CM:375.3
has cross-reference: SNOMEDCT_US_2020_03_01:302900006
has cross-reference: UMLS_CUI:C0339129
has_obo_namespace: disease_ontology
id: DOID:6970

pancreatic cholera
type: Class
subclass of: endocrine pancreas disease
imported from: doid.owl
has cross-reference: MESH:D003969
has cross-reference: NCI:C3488
has cross-reference: SNOMEDCT_US_2020_03_01:70091000
has cross-reference: UMLS_CUI:C0086768
alternative_term: Excessive vasoactive intestinal peptide secretion
alternative_term: Verner-Morrison syndrome
alternative_term: pancreatic WDHA syndrome
has_obo_namespace: disease_ontology
id: DOID:6977
in subset: NCIthesaurus

dentin sensitivity
type: Class
subclass of: teeth hard tissue disease
imported from: doid.owl
has cross-reference: MESH:D003807
has cross-reference: NCI:C50778
has cross-reference: SNOMEDCT_US_2020_03_01:13468005
has cross-reference: UMLS_CUI:C0011432
alternative_term: Sensitive dentin
has_obo_namespace: disease_ontology
id: DOID:698
in subset: NCIthesaurus

mitochondrial myopathy
type: Class
subclass of: myopathy
textual definition: A myopathy that is characterized by mitochondrial dysfunction.
imported from: doid.owl
has cross-reference: MESH:D017240
has cross-reference: NCI:C101328
has cross-reference: OMIM:251900
has cross-reference: SNOMEDCT_US_2020_03_01:240096000
has cross-reference: UMLS_CUI:C0162670
alternative_term: mitochondrial cytopathy
has_obo_namespace: disease_ontology
id: DOID:699
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

disease of anatomical entity
type: Class
subclass of: disease
textual definition: A disease that manifests in a defined anatomical structure.
imported from: doid.owl
has_alternative_id: DOID:1
has_alternative_id: DOID:2
has_alternative_id: DOID:5
has_alternative_id: DOID:71
has_alternative_id: DOID:72
has_alternative_id: DOID:8
has_obo_namespace: disease_ontology
id: DOID:7

mitochondrial metabolism disease
type: Class
subclass of: inherited metabolic disorder
textual definition: An inherited metabolic disorder that involves mitochondrial metabolism dysfunction.
imported from: doid.owl
has cross-reference: GARD:7048
has cross-reference: MESH:D028361
has cross-reference: SNOMEDCT_US_2020_03_01:240096000
has cross-reference: UMLS_CUI:C0751651
has_obo_namespace: disease_ontology
id: DOID:700
in subset: DO FlyBase slim

ACTH-secreting pituitary adenoma
type: Class
subclass of: functioning pituitary adenoma
textual definition: A functioning pituitary adenoma that characterized by excess cortisol a primary cause of Cushing's syndrome.
imported from: doid.owl
has cross-reference: GARD:12867
has cross-reference: MESH:D049913
has cross-reference: NCI:C7462
has cross-reference: OMIM:219090
has cross-reference: SNOMEDCT_US_2020_03_01:254958004
has cross-reference: UMLS_CUI:C1306214
alternative_term: ACTH-Producing Pituitary Adenoma
alternative_term: Corticotroph adenoma
alternative_term: Corticotropinoma
has_obo_namespace: disease_ontology
id: DOID:7004
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

gemistocytic astrocytoma
type: Class
subclass of: astrocytoma
imported from: doid.owl
has cross-reference: MESH:D001254
has cross-reference: NCI:C4321
has cross-reference: SNOMEDCT_US_2020_03_01:73982001
has cross-reference: UMLS_CUI:C0334581
alternative_term: Gemistocytic Astrocytic tumor
alternative_term: Gemistocytic astrocytoma
has_obo_namespace: disease_ontology
id: DOID:7005
in subset: NCIthesaurus

dentin dysplasia
type: Class
subclass of: teeth hard tissue disease
textual definition: A teeth hard tissue disease characterized by presence of normal enamel but atypical dentin with abnormal pulpal morphology.
imported from: doid.owl
has cross-reference: ICD10CM:K00.5
has cross-reference: MESH:D003805
has cross-reference: OMIM:125400
has cross-reference: OMIM:125420
has cross-reference: ORDO:1635
has cross-reference: SNOMEDCT_US_2020_03_01:109492001
has cross-reference: UMLS_CUI:C0011430
alternative_term: Dentinal dysplasia
has_obo_namespace: disease_ontology
id: DOID:701
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

anisakiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.
imported from: doid.owl
has cross-reference: GARD:693
has cross-reference: ICD10CM:B81.0
has cross-reference: ICD9CM:127.1
has cross-reference: MESH:D017129
has cross-reference: NCI:C128393
has cross-reference: SNOMEDCT_US_2020_03_01:442652006
has cross-reference: UMLS_CUI:C0162576
alternative_term: Infection by Anisakis larva
has_obo_namespace: disease_ontology
id: DOID:7033
in subset: NCIthesaurus

Leber hereditary optic neuropathy
type: Class
subclass of: optic nerve disease
imported from: doid.owl
has cross-reference: GARD:6870
has cross-reference: ICD10CM:H47.22
has cross-reference: MESH:D029242
has cross-reference: NCI:C84808
has cross-reference: OMIM:535000
has cross-reference: SNOMEDCT_US_2020_03_01:194045006
has cross-reference: UMLS_CUI:C0917796
alternative_term: Leber's hereditary optic neuropathy
alternative_term: Leber's optic atrophy
has_obo_namespace: disease_ontology
id: DOID:705
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

mature B-cell neoplasm
type: Class
subclass of: B-cell lymphoma
imported from: doid.owl
has cross-reference: EFO:0000096
has cross-reference: NCI:C27910
has cross-reference: UMLS_CUI:C1334633
alternative_term: mature B-cell lymphocytic neoplasm
has_obo_namespace: disease_ontology
id: DOID:706
in subset: DO cancer slim
in subset: NCIthesaurus

B-cell lymphoma
type: Class
subclass of: non-Hodgkin lymphoma
textual definition: A non-Hodgkin lymphoma that has_material_basis_in B cells.
imported from: doid.owl
has cross-reference: GARD:5877
has cross-reference: MESH:D016393
has cross-reference: NCI:C3457
has cross-reference: SNOMEDCT_US_2020_03_01:109979007
has cross-reference: UMLS_CUI:C0079731
alternative_term: B-cell lymphocytic neoplasm
has_obo_namespace: disease_ontology
id: DOID:707
in subset: DO cancer slim
in subset: NCIthesaurus

prostate small cell carcinoma
type: Class
subclass of: prostate cancer
subclass of: carcinoma
imported from: doid.owl
has cross-reference: NCI:C6766
has cross-reference: SNOMEDCT_US_2020_03_01:396198006
has cross-reference: UMLS_CUI:C1300585
alternative_term: prostate Oat cell carcinoma
alternative_term: small cell carcinoma of prostate
has_obo_namespace: disease_ontology
id: DOID:7141
in subset: NCIthesaurus

Langerhans cell sarcoma
type: Class
subclass of: sarcoma
subclass of: histiocytic and dendritic cell cancer
subclass of: DOID 9500
textual definition: A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones.
imported from: doid.owl
has cross-reference: ICD10CM:C96.4
has cross-reference: MESH:D054752
has cross-reference: NCI:C6921
has cross-reference: SNOMEDCT_US_2020_03_01:724649000
has cross-reference: UMLS_CUI:C1260327
has_obo_namespace: disease_ontology
id: DOID:7146
in subset: NCIthesaurus

ankylosing spondylitis
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: spinal disease
subclass of: bone inflammation disease
textual definition: A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.
imported from: doid.owl
has cross-reference: EFO:0003898
has cross-reference: GARD:9518
has cross-reference: ICD10CM:M45
has cross-reference: ICD9CM:720.0
has cross-reference: MESH:D013167
has cross-reference: NCI:C84564
has cross-reference: OMIM:PS106300
has cross-reference: ORDO:825
has cross-reference: SNOMEDCT_US_2020_03_01:156619005
has cross-reference: UMLS_CUI:C0038013
alternative_term: Bekhterev syndrome
alternative_term: Bekhterev's disease
alternative_term: Marie-Strumpell disease
has_obo_namespace: disease_ontology
id: DOID:7147
in subset: DO rare slim
in subset: NCIthesaurus

rheumatoid arthritis
type: Class
subclass of: autoimmune disease of musculoskeletal system
subclass of: arthritis
textual definition: An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.
imported from: doid.owl
has cross-reference: EFO:0000685
has cross-reference: ICD10CM:M06.9
has cross-reference: ICD9CM:714.0
has cross-reference: KEGG:05323
has cross-reference: MESH:D001172
has cross-reference: NCI:C2884
has cross-reference: OMIM:180300
has cross-reference: SNOMEDCT_US_2020_03_01:156471009
has cross-reference: UMLS_CUI:C0003873
alternative_term: Arthritis or polyarthritis, rheumatic
alternative_term: atrophic Arthritis
has_obo_namespace: disease_ontology
id: DOID:7148
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

T-cell lymphoblastic leukemia/lymphoma
type: Class
subclass of: T-cell acute lymphoblastic leukemia
imported from: doid.owl
has cross-reference: MESH:D015458
has cross-reference: UMLS_CUI:C0023492
alternative_term: T-cell leukemia
has_obo_namespace: disease_ontology
id: DOID:715
in subset: DO cancer slim

subacute thyroiditis
type: Class
subclass of: thyroiditis
imported from: doid.owl
has cross-reference: ICD10CM:E06.1
has cross-reference: ICD9CM:245.1
has cross-reference: MESH:D013968
has cross-reference: NCI:C35071
has cross-reference: SNOMEDCT_US_2020_03_01:154666006
has cross-reference: UMLS_CUI:C0040149
alternative_term: De Quervain's thyroiditis
alternative_term: Giant-cell thyroiditis
alternative_term: Granulomatous thyroiditis
alternative_term: Subacute Granulomatous Thyroiditis
alternative_term: Subacute Thyroiditis
alternative_term: Subacute thyroiditis
alternative_term: de Quervain's thyroiditis
has_obo_namespace: disease_ontology
id: DOID:7165
in subset: NCIthesaurus

thyroiditis
type: Class
subclass of: thyroid gland disease
imported from: doid.owl
has cross-reference: ICD10CM:E06
has cross-reference: ICD9CM:245
has cross-reference: MESH:D013966
has cross-reference: NCI:C26894
has cross-reference: SNOMEDCT_US_2020_03_01:154664009
has cross-reference: UMLS_CUI:C0040147
has_obo_namespace: disease_ontology
id: DOID:7166
in subset: NCIthesaurus
comment: Updating to more specific UMLS_CUI from C0029495 to C0040147.

cloacogenic carcinoma
type: Class
subclass of: anal squamous cell carcinoma
imported from: doid.owl
has cross-reference: NCI:C8255
has cross-reference: SNOMEDCT_US_2020_03_01:84570003
has cross-reference: UMLS_CUI:C0334273
alternative_term: Cloacogenic anal carcinoma
alternative_term: Cloacogenic carcinoma
has_obo_namespace: disease_ontology
id: DOID:7173
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

autoimmune hemolytic anemia
type: Class
subclass of: autoimmune disease of blood
textual definition: An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.
imported from: doid.owl
has cross-reference: GARD:5870
has cross-reference: ICD9CM:283.0
has cross-reference: MESH:D000744
has cross-reference: NCI:C34378
has cross-reference: OMIM:205700
has cross-reference: SNOMEDCT_US_2020_03_01:25121006
has cross-reference: UMLS_CUI:C0002880
alternative_term: Autoimmune haemolytic anaemia
alternative_term: Autoimmune hemolytic anaemia
alternative_term: Autoimmune hemolytic anemia
alternative_term: autoimmune hemolytic anaemia
has_obo_namespace: disease_ontology
id: DOID:718
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

subacute lymphocytic thyroiditis
type: Class
subclass of: thyroiditis
imported from: doid.owl
has cross-reference: NCI:C35829
has cross-reference: SNOMEDCT_US_2020_03_01:361126006
has cross-reference: UMLS_CUI:C1306804
alternative_term: Subacute lymphocytic thyroiditis
has_obo_namespace: disease_ontology
id: DOID:7187
in subset: NCIthesaurus

autoimmune thyroiditis
type: Class
subclass of: autoimmune disease of endocrine system
textual definition: An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.
imported from: doid.owl
has_alternative_id: DOID:0050435
has cross-reference: ICD10CM:E06.3
has cross-reference: MESH:D013967
has cross-reference: NCI:C38766
has cross-reference: SNOMEDCT_US_2020_03_01:190297000
has cross-reference: UMLS_CUI:C0920350
alternative_term: Chronic Lymphocytic Thyroiditis
alternative_term: Hashimoto thyroiditis
alternative_term: Hashimoto's Disease
alternative_term: Hashimoto's syndrome
alternative_term: Hashimoto's thyroiditis
alternative_term: Lymphocytic Thyroiditis
has_obo_namespace: disease_ontology
id: DOID:7188
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

normocytic anemia
type: Class
subclass of: anemia
imported from: doid.owl
has cross-reference: NCI:C35142
has cross-reference: SNOMEDCT_US_2020_03_01:300980002
has cross-reference: UMLS_CUI:C0085577
alternative_term: ANEMIA NORMOCYTIC
has_obo_namespace: disease_ontology
id: DOID:720
in subset: NCIthesaurus

melanomatosis
type: Class
subclass of: melanoma
imported from: doid.owl
has cross-reference: NCI:C9499
has cross-reference: UMLS_CUI:C1334691
has_obo_namespace: disease_ontology
id: DOID:7206
in subset: NCIthesaurus

psammomatous meningioma
type: Class
subclass of: meningioma
imported from: doid.owl
has cross-reference: MESH:D008579
has cross-reference: NCI:C4331
has cross-reference: SNOMEDCT_US_2020_03_01:38431002
has cross-reference: UMLS_CUI:C0334607
alternative_term: Psammomatous meningioma
has_obo_namespace: disease_ontology
id: DOID:7210
in subset: NCIthesaurus

fibrous meningioma
type: Class
subclass of: meningioma
imported from: doid.owl
has cross-reference: MESH:D008579
has cross-reference: NCI:C4330
has cross-reference: SNOMEDCT_US_2020_03_01:511008
has cross-reference: UMLS_CUI:C0334606
alternative_term: Fibroblastic meningioma
has_obo_namespace: disease_ontology
id: DOID:7211
in subset: NCIthesaurus

breast giant fibroadenoma
type: Class
subclass of: breast fibroadenoma
textual definition: A breast fibroadenoma that is larger than 5 cm.
imported from: doid.owl
has cross-reference: NCI:C4273
has cross-reference: SNOMEDCT_US_2020_03_01:254846003
has cross-reference: UMLS_CUI:C0346157
alternative_term: Giant Fibroadenoma
alternative_term: Giant fibroadenoma of breast
has_obo_namespace: disease_ontology
id: DOID:7223
in subset: NCIthesaurus

female stress incontinence
type: Class
subclass of: bladder disease
imported from: doid.owl
has cross-reference: ICD9CM:625.6
has cross-reference: NCI:C35042
has cross-reference: SNOMEDCT_US_2020_03_01:60241006
has cross-reference: UMLS_CUI:C0038437
alternative_term: Stress incontinence - female
alternative_term: female urinary stress incontinence
has_obo_namespace: disease_ontology
id: DOID:724
in subset: NCIthesaurus

astroblastoma
type: Class
subclass of: astrocytoma
imported from: doid.owl
has cross-reference: GARD:10635
has cross-reference: MESH:D018302
has cross-reference: NCI:C4324
has cross-reference: SNOMEDCT_US_2020_03_01:48952003
has cross-reference: UMLS_CUI:C0334587
alternative_term: Astroblastoma
has_obo_namespace: disease_ontology
id: DOID:7305
in subset: NCIthesaurus

urinary system benign neoplasm
type: Class
subclass of: organ system benign neoplasm
subclass of: urinary system disease
textual definition: An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.
imported from: doid.owl
has cross-reference: MESH:D014571
has cross-reference: NCI:C3431
has cross-reference: SNOMEDCT_US_2020_03_01:254913005
has cross-reference: UMLS_CUI:C0042076
alternative_term: neoplasm of urinary system
alternative_term: tumor of the urinary system
alternative_term: tumor of urinary tract
alternative_term: urinary tract neoplasm
has_obo_namespace: disease_ontology
id: DOID:731
in subset: NCIthesaurus

axonal neuropathy
type: Class
subclass of: DOID 870
imported from: doid.owl
has cross-reference: NCI:C27301
has cross-reference: SNOMEDCT_US_2020_03_01:60703000
has cross-reference: UMLS_CUI:C0270921
has_obo_namespace: disease_ontology
id: DOID:7319
in subset: NCIthesaurus

urethral disease
type: Class
subclass of: urinary system disease
textual definition: A urinary system disease that is located_in the urethra.
imported from: doid.owl
has cross-reference: ICD10CM:N36.9
has cross-reference: MESH:D014522
has cross-reference: NCI:C26903
has cross-reference: SNOMEDCT_US_2020_03_01:4985009
has cross-reference: UMLS_CUI:C0041969
alternative_term: urethra disease
has_obo_namespace: disease_ontology
id: DOID:732
in subset: NCIthesaurus

pseudosarcomatous fibromatosis
type: Class
subclass of: DOID 9598
imported from: doid.owl
has cross-reference: ICD10CM:M72.4
has cross-reference: NCI:C3827
has cross-reference: SNOMEDCT_US_2020_03_01:268106003
has cross-reference: UMLS_CUI:C0410005
alternative_term: Fasciitis - nodular
alternative_term: Pseudosarcomatous Fasciitis
alternative_term: Pseudosarcomatous fibromatosis
alternative_term: nodular fasciitis
has_obo_namespace: disease_ontology
id: DOID:7327
in subset: NCIthesaurus

nephrogenic adenoma of urinary bladder
type: Class
subclass of: bladder benign neoplasm
subclass of: adenoma
imported from: doid.owl
has cross-reference: NCI:C7415
has cross-reference: UMLS_CUI:C1336892
alternative_term: Nephrogenic adenoma of the urinary bladder
has_obo_namespace: disease_ontology
id: DOID:7333
in subset: NCIthesaurus

nephrogenic adenoma
type: Class
subclass of: kidney benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C97097
has cross-reference: SNOMEDCT_US_2020_03_01:78236000
has cross-reference: UMLS_CUI:C0334039
has_obo_namespace: disease_ontology
id: DOID:7334
in subset: NCIthesaurus

urethra cancer
type: Class
subclass of: urinary system cancer
subclass of: urethral disease
textual definition: An urinary tract cancer that derives_from the tissues of the urethra.
imported from: doid.owl
has_alternative_id: DOID:737
has cross-reference: GARD:9390
has cross-reference: ICD10CM:C68.0
has cross-reference: ICD9CM:189.3
has cross-reference: MESH:D014523
has cross-reference: NCI:C7507
has cross-reference: NCI:C9106
has cross-reference: SNOMEDCT_US_2020_03_01:363459007
has cross-reference: SNOMEDCT_US_2020_03_01:94123008
has cross-reference: UMLS_CUI:C0153620
has cross-reference: UMLS_CUI:C0700101
alternative_term: malignant tumour of urethra
alternative_term: malignant urethral neoplasm
alternative_term: urethral Ca
has_obo_namespace: disease_ontology
has_related_synonym: cancer of urethra
id: DOID:734
in subset: NCIthesaurus

Kimura disease
type: Class
subclass of: skin disease
imported from: doid.owl
has cross-reference: GARD:6835
has cross-reference: MESH:D000796
has cross-reference: NCI:C26867
has cross-reference: SNOMEDCT_US_2020_03_01:399894006
has cross-reference: UMLS_CUI:C0033838
alternative_term: Kimura's disease
has_obo_namespace: disease_ontology
id: DOID:7365
in subset: NCIthesaurus

pituitary hypoplasia
type: Class
subclass of: pituitary gland disease
imported from: doid.owl
has cross-reference: NCI:C27343
has cross-reference: UMLS_CUI:C0948740
has_obo_namespace: disease_ontology
id: DOID:7378
in subset: NCIthesaurus

hematopoietic system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that has_material_basis_in hematopoietic cells.
imported from: doid.owl
has cross-reference: ICD10CM:D75.9
has cross-reference: ICD9CM:289.9
has cross-reference: MESH:D006402
has cross-reference: NCI:C26323
has cross-reference: SNOMEDCT_US_2020_03_01:154785002
has cross-reference: UMLS_CUI:C0018939
alternative_term: Blood disease
alternative_term: Blood dyscrasia
alternative_term: DISEASE OF THE BLOOD AND BLOOD-FORMING ORGANS
alternative_term: Hematological disease
alternative_term: blood disorder
alternative_term: disease of haematopoietic system
alternative_term: disease of hematopoietic system
alternative_term: haematopoietic system disease
has_obo_namespace: disease_ontology
id: DOID:74
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

Nijmegen breakage syndrome
type: Class
subclass of: autosomal recessive disease
subclass of: syndrome
textual definition: A syndrome characterized by chromosomal instability, microcephaly, growth retardation, immunodeficiency, cellular hypersensitivity to X-rays, and predisposition to cancer that has_material_basis_in homozygous or compound heterozygous mutation in NBN on chromosome 8q21.3.
imported from: doid.owl
has cross-reference: GARD:3904
has cross-reference: MESH:D049932
has cross-reference: NCI:C4692
has cross-reference: OMIM:251260
has cross-reference: ORDO:647
has cross-reference: SNOMEDCT_US_2020_03_01:234638009
has cross-reference: UMLS_CUI:C0398791
alternative_term: Berlin breakage syndrome
alternative_term: Microcephaly, normal intelligence and immunodeficiency
alternative_term: NBS
alternative_term: Seemanova syndrome II
alternative_term: Seemanova syndrome type 2
alternative_term: ataxia-telangiectasia variant
alternative_term: immunodeficiency-microcephaly-chromosomal instability syndrome
alternative_term: microcephaly-immunodeficiency-lymphoreticuloma syndrome
has_obo_namespace: disease_ontology
id: DOID:7400
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cutaneous anthrax
type: Class
subclass of: skin disease
subclass of: anthrax disease
textual definition: An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center.
imported from: doid.owl
has cross-reference: GARD:8158
has cross-reference: ICD10CM:A22.0
has cross-reference: ICD9CM:022.0
has cross-reference: MESH:C531621
has cross-reference: SNOMEDCT_US_2020_03_01:84980006
has cross-reference: UMLS_CUI:C0003177
has_obo_namespace: disease_ontology
id: DOID:7426
in subset: gram-positive bacterial infectious disease
in subset: zoonotic infectious disease

anthrax disease
type: Class
subclass of: primary bacterial infectious disease
textual definition: A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.
imported from: doid.owl
has cross-reference: GARD:8157
has cross-reference: ICD10CM:A22
has cross-reference: ICD9CM:022
has cross-reference: MESH:D000881
has cross-reference: NCI:C84565
has cross-reference: SNOMEDCT_US_2020_03_01:154295005
has cross-reference: UMLS_CUI:C0003175
has_obo_namespace: disease_ontology
id: DOID:7427
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease
in subset: zoonotic infectious disease

monoclonal gammopathy of uncertain significance
type: Class
subclass of: blood protein disease
textual definition: A blood protein disease that is characterized by the presence of an abnormal protein called monoclonal protein in the blood.
imported from: doid.owl
has cross-reference: GARD:7034
alternative_term: MGUS
alternative_term: Monoclonal gammopathy of uncertain significance
alternative_term: Monoclonal gammopathy of undetermined significance
has_obo_namespace: disease_ontology
id: DOID:7442

enterobiasis
type: Class
subclass of: DOID 883
textual definition: A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching.
imported from: doid.owl
has_alternative_id: DOID:7458
has cross-reference: ICD10CM:B80
has cross-reference: MESH:D010123
has cross-reference: SNOMEDCT_US_2020_03_01:154415009
has cross-reference: UMLS_CUI:C0030100
alternative_term: Oxyuris vermicularis infection
alternative_term: Threadworm infection
has_obo_namespace: disease_ontology
has_related_synonym: Enterobius vermicularis infection
has_related_synonym: Pinworm infection
has_related_synonym: oxyuriasis
id: DOID:7457

chronic NK-cell lymphocytosis
type: Class
subclass of: hypersensitivity reaction type IV disease
textual definition: A hypersensitivity reaction type IV disease that is characterized by absolute lymphocytosis of natural killer (CD3- CD16+) cells often with concurrent cytopenia and has_symptom fever, arthralgia, apthous ulcers, vasculitic skin rash, and peripheral neuropathy.
imported from: doid.owl
has cross-reference: NCI:C39591
has cross-reference: SNOMEDCT_US_2020_03_01:722955006
has cross-reference: UMLS_CUI:C1512709
alternative_term: NK-cell large granular Lymphocyte Lymphocytosis
has_obo_namespace: disease_ontology
id: DOID:7465
in subset: NCIthesaurus

malignant pleural mesothelioma
type: Class
subclass of: respiratory system cancer
subclass of: pleural disease
subclass of: squamous cell carcinoma
subclass of: pleural cancer
textual definition: A pleural cancer that has_material_basis_in mesothelium cells.
imported from: doid.owl
has cross-reference: ICD10CM:C45.0
has cross-reference: NCI:C7376
has cross-reference: SNOMEDCT_US_2020_03_01:254645002
has cross-reference: UMLS_CUI:C0812413
alternative_term: malignant mesothelioma of pleura
has_obo_namespace: disease_ontology
id: DOID:7474
in subset: DO cancer slim
in subset: NCIthesaurus

diverticulitis
type: Class
subclass of: intestinal disease
textual definition: An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall.
imported from: doid.owl
has cross-reference: MESH:D004238
has cross-reference: NCI:C26752
has cross-reference: SNOMEDCT_US_2020_03_01:155779000
has cross-reference: UMLS_CUI:C0012813
has_obo_namespace: disease_ontology
id: DOID:7475
in subset: NCIthesaurus

Osgood-Schlatter's disease
type: Class
subclass of: bone inflammation disease
textual definition: A bone inflammation disease that involves rupture of the growth plate in children located_in tibia.
imported from: doid.owl
has cross-reference: MESH:D055034
has cross-reference: NCI:C34874
has cross-reference: SNOMEDCT_US_2020_03_01:72047008
has cross-reference: UMLS_CUI:C0029376
alternative_term: Osgood-Schlatter disease
alternative_term: Osteochondritis of tibial tubercle
alternative_term: Osteochondrosis of proximal tibia
alternative_term: juvenile osteochondrosis of tibial tubercle
has_obo_namespace: disease_ontology
id: DOID:7489
in subset: NCIthesaurus

lymphatic system disease
type: Class
subclass of: immune system disease
textual definition: An immune system disease that is located_in the lymphatic system.
imported from: doid.owl
has cross-reference: MESH:D008206
has cross-reference: SNOMEDCT_US_2020_03_01:266326002
has cross-reference: UMLS_CUI:C0024228
alternative_term: Adenopathy
alternative_term: Lymphangiopathy
alternative_term: Lymphatic disease
alternative_term: Lymphatic disorder
alternative_term: disease of lympoid system
alternative_term: disorder of lymph node and lymphatics
alternative_term: disorder of lymphatic system
alternative_term: disorder of lymphoid system
alternative_term: lymphatic disorder
alternative_term: lympoid system disease
has_obo_namespace: disease_ontology
id: DOID:75

peptic ulcer disease
type: Class
subclass of: gastrointestinal system disease
imported from: doid.owl
has_alternative_id: DOID:11466
has_alternative_id: DOID:12635
has_alternative_id: DOID:13115
has cross-reference: ICD10CM:K27
has cross-reference: ICD9CM:533
has cross-reference: MESH:D010437
has cross-reference: NCI:C3318
has cross-reference: SNOMEDCT_US_2020_03_01:155701001
has cross-reference: UMLS_CUI:C0030920
alternative_term: acute peptic ulcer with hemorrhage
alternative_term: acute peptic ulcer with hemorrhage and perforation
alternative_term: acute peptic ulcer without hemorrhage AND without perforation
alternative_term: acute peptic ulcer without hemorrhage and without perforation
has_obo_namespace: disease_ontology
id: DOID:750
in subset: NCIthesaurus

peptic ulcer perforation
type: Class
subclass of: peptic ulcer disease
imported from: doid.owl
has_alternative_id: DOID:751
has cross-reference: MESH:D010439
has cross-reference: SNOMEDCT_US_2020_03_01:88169003
has cross-reference: UMLS_CUI:C0030925
alternative_term: Peptic ulcer with perforation
alternative_term: Perforated peptic ulcer
alternative_term: acute peptic ulcer with perforation
has_obo_namespace: disease_ontology
id: DOID:752

squamous papillomatosis
type: Class
subclass of: gastrointestinal system benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C9009
has cross-reference: SNOMEDCT_US_2020_03_01:82049002
has cross-reference: UMLS_CUI:C1378340
has_obo_namespace: disease_ontology
id: DOID:7532
in subset: NCIthesaurus

gonorrhea
type: Class
subclass of: primary bacterial infectious disease
subclass of: fallopian tube disease
subclass of: anus disease
subclass of: uterine disease
subclass of: eye disease
subclass of: urethral disease
textual definition: A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.
imported from: doid.owl
has_alternative_id: DOID:10409
has_alternative_id: DOID:13557
has cross-reference: ICD10CM:A54
has cross-reference: ICD9CM:098
has cross-reference: MESH:D006069
has cross-reference: NCI:C92950
has cross-reference: SNOMEDCT_US_2020_03_01:186943001
has cross-reference: UMLS_CUI:C0018081
alternative_term: chronic gonococcal infectious disease of lower genitourinary tract
alternative_term: chronic gonococcal infectious disease of upper genitourinary tract
has_obo_namespace: disease_ontology
id: DOID:7551
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: sexually transmitted infectious disease

situs inversus
type: Class
subclass of: visceral heterotaxy
imported from: doid.owl
has cross-reference: GARD:4883
has cross-reference: ICD10CM:Q89.3
has cross-reference: ICD9CM:759.3
has cross-reference: MESH:D012857
has cross-reference: NCI:C87121
has cross-reference: OMIM:270100
has cross-reference: SNOMEDCT_US_2020_03_01:157033002
has cross-reference: UMLS_CUI:C0037221
alternative_term: Complete transposition
alternative_term: Laterality sequence
alternative_term: situs inversus viscerum
has_obo_namespace: disease_ontology
id: DOID:758
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

stomach disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the stomach.
imported from: doid.owl
has cross-reference: MESH:D013272
has cross-reference: NCI:C26886
has cross-reference: SNOMEDCT_US_2020_03_01:196598004
has cross-reference: UMLS_CUI:C0038354
alternative_term: Gastropathy
alternative_term: stomach disorder
has_obo_namespace: disease_ontology
has_related_synonym: gastric disease
id: DOID:76
in subset: NCIthesaurus

fibrosarcomatous osteosarcoma
type: Class
subclass of: conventional central osteosarcoma
imported from: doid.owl
has cross-reference: NCI:C4020
has cross-reference: SNOMEDCT_US_2020_03_01:12690005
has cross-reference: UMLS_CUI:C0279602
alternative_term: Fibroblastic osteosarcoma
alternative_term: Fibrosarcomatous Osteogenic sarcoma
has_obo_namespace: disease_ontology
id: DOID:7603
in subset: NCIthesaurus

parathyroid adenoma
type: Class
subclass of: parathyroid gland benign neoplasm
subclass of: adenoma
textual definition: A parathyroid gland benign neoplam that is located_in the parathyroid.
imported from: doid.owl
has cross-reference: MESH:D010282
has cross-reference: NCI:C3916
has cross-reference: SNOMEDCT_US_2020_03_01:128474007
has cross-reference: UMLS_CUI:C0262587
alternative_term: adenoma of the Parathyroid gland
has_obo_namespace: disease_ontology
has_related_synonym: adenoma of parathyroid
id: DOID:7608
in subset: NCIthesaurus

sarcomatosis
type: Class
subclass of: sarcoma
textual definition: A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body.
imported from: doid.owl
has cross-reference: NCI:C4243
has cross-reference: SNOMEDCT_US_2020_03_01:9395006
has cross-reference: UMLS_CUI:C0334451
has_obo_namespace: disease_ontology
id: DOID:7615
in subset: NCIthesaurus

macular holes
type: Class
subclass of: retinal disease
imported from: doid.owl
has cross-reference: MESH:D012167
has cross-reference: NCI:C34795
has cross-reference: SNOMEDCT_US_2020_03_01:193388002
has cross-reference: UMLS_CUI:C0024441
alternative_term: Macular hole
has_obo_namespace: disease_ontology
id: DOID:7633
in subset: NCIthesaurus

suprasellar meningioma
type: Class
subclass of: meningioma
imported from: doid.owl
has cross-reference: NCI:C6776
has cross-reference: UMLS_CUI:C1336535
has_obo_namespace: disease_ontology
id: DOID:7634
in subset: NCIthesaurus

muscular atrophy
type: Class
subclass of: myopathy
imported from: doid.owl
has cross-reference: MESH:D009133
has cross-reference: NCI:C94834
has cross-reference: SNOMEDCT_US_2020_03_01:267693003
has cross-reference: UMLS_CUI:C0026846
alternative_term: Amyotrophia
alternative_term: Muscle wasting
alternative_term: Wasting - muscle
has_obo_namespace: disease_ontology
id: DOID:767
in subset: NCIthesaurus

testicular fibroma
type: Class
subclass of: male reproductive organ benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C39951
has cross-reference: UMLS_CUI:C1515282
has_obo_namespace: disease_ontology
id: DOID:7675
in subset: NCIthesaurus

retinoblastoma
type: Class
subclass of: retinal cell cancer
textual definition: A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.
imported from: doid.owl
has cross-reference: GARD:7563
has cross-reference: MESH:D012175
has cross-reference: NCI:C7541
has cross-reference: OMIM:180200
has cross-reference: SNOMEDCT_US_2020_03_01:154553002
has cross-reference: UMLS_CUI:C0035335
alternative_term: RB
alternative_term: RB - Retinoblastoma
alternative_term: neuroblastoma of Retina
has_obo_namespace: disease_ontology
id: DOID:768
in subset: DO cancer slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

neuroblastoma
type: Class
subclass of: autonomic nervous system neoplasm
textual definition: An autonomic nervous system neoplasm that derives_from immature nerve cells.
imported from: doid.owl
has cross-reference: EFO:0000621
has cross-reference: GARD:7185
has cross-reference: ICDO:M9500/3
has cross-reference: MESH:D009447
has cross-reference: NCI:C3270
has cross-reference: ORDO:635
has cross-reference: SNOMEDCT_US_2020_03_01:432328008
has cross-reference: UMLS_CUI:C0027819
has_obo_namespace: disease_ontology
id: DOID:769
in subset: DO cancer slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

abdominal aortic aneurysm
type: Class
subclass of: aortic aneurysm
textual definition: An aortic aneurysm that is located_in the abdominal aorta.
imported from: doid.owl
has cross-reference: EFO:0004214
has cross-reference: GARD:9181
has cross-reference: MESH:D017544
has cross-reference: NCI:C27000
has cross-reference: OMIM:100070
has cross-reference: OMIM:609782
has cross-reference: OMIM:611891
has cross-reference: OMIM:614375
has cross-reference: SNOMEDCT_US_2020_03_01:155422008
has cross-reference: UMLS_CUI:C0162871
alternative_term: AORTIC ANEURYSM, FAMILIAL ABDOMINAL 1
has_obo_namespace: disease_ontology
id: DOID:7693
in subset: NCIthesaurus

gastrointestinal system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in the gastrointestinal tract.
imported from: doid.owl
has_alternative_id: DOID:27
has_alternative_id: DOID:944
has cross-reference: ICD10CM:K92.9
has cross-reference: ICD9CM:520-579.99
has cross-reference: MESH:D004066
has cross-reference: SNOMEDCT_US_2020_03_01:53619000
has cross-reference: UMLS_CUI:C0012242
alternative_term: GIT disease
alternative_term: Gastroenteropathy
alternative_term: alimentary system disease
alternative_term: digestive system disorder
alternative_term: gastrointestinal disease
alternative_term: gastrointestinal disorder
has_obo_namespace: disease_ontology
id: DOID:77
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

retinal cell cancer
type: Class
subclass of: retinal cancer
textual definition: A malignant neoplasm that derives_from the retina.
imported from: doid.owl
has cross-reference: NCI:C7061
has cross-reference: UMLS_CUI:C1335765
has_obo_namespace: disease_ontology
id: DOID:771
in subset: DO cancer slim
in subset: NCIthesaurus

epilepsy with generalized tonic-clonic seizures
type: Class
subclass of: adolescence-adult electroclinical syndrome
textual definition: An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type.
imported from: doid.owl
has cross-reference: MESH:D004830
has cross-reference: NCI:C3022
has cross-reference: SNOMEDCT_US_2020_03_01:352818000
has cross-reference: UMLS_CUI:C0014549
alternative_term: Epileptic seizures, tonic-clonic
alternative_term: Grand Mal epilepsy
alternative_term: tonic-clonic epilepsy
has_obo_namespace: disease_ontology
id: DOID:7725
in subset: NCIthesaurus
comment: JA:Epilepsy Genetics Kiel

retinal telangiectasia
type: Class
subclass of: retinal vascular disease
imported from: doid.owl
has cross-reference: ICD9CM:362.15
has cross-reference: SNOMEDCT_US_2020_03_01:84884003
has cross-reference: UMLS_CUI:C0154835
has_obo_namespace: disease_ontology
id: DOID:7736

intraocular lymphoma
type: Class
subclass of: eye lymphoma
imported from: doid.owl
has_alternative_id: DOID:7746
has cross-reference: MESH:D064090
has cross-reference: NCI:C9184
has cross-reference: UMLS_CUI:C0281658
alternative_term: primary intraocular lymphoma
has_obo_namespace: disease_ontology
id: DOID:775
in subset: NCIthesaurus

Coats disease
type: Class
subclass of: retinal telangiectasia
imported from: doid.owl
has cross-reference: GARD:6121
has cross-reference: ICD10CM:H35.02
has cross-reference: ICD9CM:362.12
has cross-reference: MESH:D058456
has cross-reference: OMIM:300216
has cross-reference: SNOMEDCT_US_2020_03_01:193359003
has cross-reference: UMLS_CUI:C0154832
alternative_term: Coats' disease
alternative_term: Coats' syndrome
alternative_term: Exudative retinopathy
has_obo_namespace: disease_ontology
id: DOID:7765
comment: OMIM mapping confirmed by DO. [SN].

delusional disorder
type: Class
subclass of: psychotic disorder
textual definition: A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.
imported from: doid.owl
has cross-reference: ICD10CM:F22
has cross-reference: ICD9CM:297.1
has cross-reference: MESH:D012563
has cross-reference: NCI:C94379
has cross-reference: SNOMEDCT_US_2020_03_01:48500005
has cross-reference: UMLS_CUI:C0011251
has_obo_namespace: disease_ontology
id: DOID:778
in subset: NCIthesaurus

placenta disease
type: Class
subclass of: uterine disease
textual definition: A uterine disease that is located_in the placenta.
imported from: doid.owl
has_alternative_id: DOID:1815
has_alternative_id: DOID:5366
has_alternative_id: DOID:9219
has cross-reference: GARD:7402
has cross-reference: ICD10CM:O43
has cross-reference: ICD9CM:646.9
has cross-reference: MESH:D010922
has cross-reference: MESH:D011248
has cross-reference: NCI:C26857
has cross-reference: NCI:C27619
has cross-reference: NCI:C34941
has cross-reference: NCI:C35169
has cross-reference: SNOMEDCT_US_2020_03_01:125586008
has cross-reference: SNOMEDCT_US_2020_03_01:172422001
has cross-reference: SNOMEDCT_US_2020_03_01:198881004
has cross-reference: UMLS_CUI:C0032045
has cross-reference: UMLS_CUI:C0032962
has cross-reference: UMLS_CUI:C0151864
has cross-reference: UMLS_CUI:C1335423
has_obo_namespace: disease_ontology
id: DOID:780
in subset: NCIthesaurus

petroclival meningioma
type: Class
subclass of: skull base meningioma
imported from: doid.owl
has cross-reference: NCI:C5278
has cross-reference: UMLS_CUI:C1335395
has_obo_namespace: disease_ontology
id: DOID:7818
in subset: NCIthesaurus

end stage renal disease
type: Class
subclass of: chronic kidney disease
textual definition: A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.
imported from: doid.owl
has cross-reference: ICD9CM:585.6
alternative_term: end stage renal failure
alternative_term: end-stage kidney disease
has_obo_namespace: disease_ontology
id: DOID:783

chronic kidney disease
type: Class
subclass of: kidney failure
textual definition: A kidney failure that is characterized by the gradual loss of kidney function.
imported from: doid.owl
has cross-reference: ICD10CM:N18.9
has cross-reference: ICD9CM:585.6
has cross-reference: MESH:D007676
has cross-reference: NCI:C9438
has cross-reference: SNOMEDCT_US_2020_03_01:155856009
has cross-reference: UMLS_CUI:C0022661
alternative_term: CKD
alternative_term: CRF
alternative_term: chronic kidney failure
alternative_term: chronic renal disease
alternative_term: chronic renal failure syndrome
alternative_term: renal failure - chronic
has_obo_namespace: disease_ontology
id: DOID:784
in subset: NCIthesaurus

female breast carcinoma
type: Class
subclass of: breast carcinoma
textual definition: A breast carcinoma that is manifested in the female breast.
imported from: doid.owl
has cross-reference: NCI:C2918
has cross-reference: UMLS_CUI:C0007104
alternative_term: Mammary carcinoma of female breast
has_obo_namespace: disease_ontology
has_related_synonym: carcinoma of female breast
id: DOID:7843
in subset: NCIthesaurus

dendritic cell sarcoma
type: Class
subclass of: sarcoma
subclass of: histiocytic and dendritic cell cancer
textual definition: A histiocytic and dendritic cell cancer that is mainly located_in lymph nodes.
imported from: doid.owl
has cross-reference: NCI:C27260
has cross-reference: SNOMEDCT_US_2020_03_01:397355008
has cross-reference: UMLS_CUI:C1301364
alternative_term: Dendritic cell sarcoma
alternative_term: Dendritic cell sarcoma, not otherwise specified
has_obo_namespace: disease_ontology
has_related_synonym: follicular dendritic cell sarcoma
id: DOID:7849
in subset: NCIthesaurus

laryngeal disease
type: Class
subclass of: DOID 974
imported from: doid.owl
has cross-reference: ICD10CM:S12.8
has cross-reference: ICD9CM:478.70
has cross-reference: MESH:D007818
has cross-reference: NCI:C26810
has cross-reference: SNOMEDCT_US_2020_03_01:195863001
has cross-reference: UMLS_CUI:C0023051
has_obo_namespace: disease_ontology
id: DOID:786
in subset: NCIthesaurus

luteoma
type: Class
subclass of: ovarian benign neoplasm
textual definition: An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium.
imported from: doid.owl
has cross-reference: NCI:C40445
has cross-reference: UMLS_CUI:C1517842
alternative_term: leuteoma of pregnancy
alternative_term: luteoma of pregnancy
has_obo_namespace: disease_ontology
id: DOID:7880
in subset: NCIthesaurus

mite infestation
type: Class
subclass of: parasitic ectoparasitic infectious disease
textual definition: A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae.
imported from: doid.owl
has cross-reference: ICD10CM:B88.9
has cross-reference: ICD9CM:133
has cross-reference: MESH:D008924
has cross-reference: SNOMEDCT_US_2020_03_01:78166003
has cross-reference: UMLS_CUI:C0026229
has_obo_namespace: disease_ontology
id: DOID:7894

ocular hypotension
type: Class
subclass of: eye disease
imported from: doid.owl
has cross-reference: ICD10CM:H44.4
has cross-reference: ICD9CM:360.3
has cross-reference: MESH:D015814
has cross-reference: SNOMEDCT_US_2020_03_01:23670006
has cross-reference: UMLS_CUI:C0028841
alternative_term: Hypotony of eye
has_obo_namespace: disease_ontology
id: DOID:790

epithelial malignant thymoma
type: Class
subclass of: dendritic cell thymoma
imported from: doid.owl
has cross-reference: NCI:C7997
has cross-reference: SNOMEDCT_US_2020_03_01:128715000
has cross-reference: UMLS_CUI:C0279705
alternative_term: Squamoid Thymoma
alternative_term: Thymoma, epithelial
alternative_term: Well differentiated thymic carcinoma
has_obo_namespace: disease_ontology
id: DOID:7926
in subset: NCIthesaurus

varicose veins
type: Class
subclass of: DOID 866
textual definition: A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.
imported from: doid.owl
has cross-reference: ICD10CM:I83.90
has cross-reference: MESH:D014648
has cross-reference: NCI:C35114
has cross-reference: OMIM:192200
has cross-reference: SNOMEDCT_US_2020_03_01:276504003
has cross-reference: UMLS_CUI:C0042345
alternative_term: Varix
alternative_term: Venous ectasia
alternative_term: Venous varices
alternative_term: varices
has_obo_namespace: disease_ontology
id: DOID:799
in subset: NCIthesaurus

thyrotoxicosis
type: Class
subclass of: thyroid gland disease
textual definition: A thyroid gland disease that is characterized by excess thyroid hormone.
imported from: doid.owl
has cross-reference: ICD10CM:E05.9
has cross-reference: ICD9CM:242
has cross-reference: MESH:D013971
has cross-reference: NCI:C61469
has cross-reference: SNOMEDCT_US_2020_03_01:154655004
has cross-reference: UMLS_CUI:C0040156
has_obo_namespace: disease_ontology
id: DOID:7997
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

hyperthyroidism
type: Class
subclass of: thyroid gland disease
textual definition: A thyroid gland disease that involves an over production of thyroid hormone.
imported from: doid.owl
has cross-reference: ICD10CM:E05.9
has cross-reference: MESH:D006980
has cross-reference: NCI:C3123
has cross-reference: OMIM:603373
has cross-reference: OMIM:609152
has cross-reference: ORDO:99819
has cross-reference: SNOMEDCT_US_2020_03_01:190239004
has cross-reference: UMLS_CUI:C0020550
alternative_term: overactive thyroid
has_obo_namespace: disease_ontology
id: DOID:7998
in subset: NCIthesaurus
comment: Xref MGI.

alveoli adenoma
type: Class
subclass of: bronchial benign neoplasm
subclass of: adenoma
imported from: doid.owl
has cross-reference: NCI:C4140
has cross-reference: SNOMEDCT_US_2020_03_01:8097004
has cross-reference: UMLS_CUI:C0334303
alternative_term: Alveolar adenoma
alternative_term: adenoma of alveoli
has_obo_namespace: disease_ontology
has_related_synonym: adenoma of the alveoli
id: DOID:8003
in subset: NCIthesaurus

hemarthrosis
type: Class
subclass of: arthropathy
imported from: doid.owl
has_alternative_id: DOID:12025
has_alternative_id: DOID:13059
has_alternative_id: DOID:13646
has_alternative_id: DOID:13933
has_alternative_id: DOID:14242
has_alternative_id: DOID:800
has_alternative_id: DOID:953
has cross-reference: ICD10CM:M25.0
has cross-reference: ICD9CM:719.1
has cross-reference: MESH:D006395
has cross-reference: SNOMEDCT_US_2020_03_01:156581006
has cross-reference: UMLS_CUI:C0018924
alternative_term: Haemarthrosis of shoulder joint
alternative_term: Haemarthrosis of the ankle and foot
alternative_term: Haemarthrosis of the pelvic region and thigh
alternative_term: Hemarthrosis involving ankle and foot
alternative_term: Hemarthrosis involving forearm
alternative_term: Hemarthrosis involving hand
alternative_term: Hemarthrosis involving lower leg
alternative_term: Hemarthrosis involving pelvic region and thigh
alternative_term: Hemarthrosis involving shoulder region
alternative_term: Hemarthrosis involving upper arm
alternative_term: Hemarthrosis of ankle and/or foot
alternative_term: Hemarthrosis of forearm
alternative_term: Hemarthrosis of hand
alternative_term: Hemarthrosis of lower leg
alternative_term: Hemarthrosis of shoulder
alternative_term: Hemarthrosis of shoulder region
alternative_term: Hemarthrosis of the ankle and foot
alternative_term: Hemarthrosis of the ankle and/or foot
alternative_term: Hemarthrosis of the forearm
alternative_term: Hemarthrosis of the hand
alternative_term: Hemarthrosis of the lower leg
alternative_term: Hemarthrosis of the pelvic region and thigh
alternative_term: Hemarthrosis of the shoulder region
alternative_term: Hemarthrosis of the upper arm
alternative_term: Hemarthrosis of upper arm
has_obo_namespace: disease_ontology
id: DOID:801

sporadic breast cancer
type: Class
subclass of: breast carcinoma
textual definition: A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer.
imported from: doid.owl
has cross-reference: NCI:C7566
has cross-reference: UMLS_CUI:C1336076
has_obo_namespace: disease_ontology
id: DOID:8029
in subset: NCIthesaurus

pineal region meningioma
type: Class
subclass of: meningioma
subclass of: pineal gland cancer
imported from: doid.owl
has cross-reference: NCI:C6756
has cross-reference: UMLS_CUI:C1335418
alternative_term: Pineal meningioma
has_obo_namespace: disease_ontology
id: DOID:8031
in subset: NCIthesaurus

frontal sinus inverted papilloma
type: Class
subclass of: frontal sinus benign neoplasm
subclass of: papilloma
imported from: doid.owl
has cross-reference: NCI:C6842
has cross-reference: UMLS_CUI:C1333644
alternative_term: Inverted papilloma of the Frontal sinus
has_obo_namespace: disease_ontology
id: DOID:8060
in subset: NCIthesaurus

carotid artery occlusion
type: Class
subclass of: carotid artery disease
subclass of: occlusion precerebral artery
imported from: doid.owl
has cross-reference: ICD9CM:433.10
has cross-reference: UMLS_CUI:C0375275
alternative_term: Occlusion and stenosis of carotid artery
has_obo_namespace: disease_ontology
id: DOID:807

cocaine abuse
type: Class
subclass of: substance abuse
textual definition: A substance abuse that involves the recurring use of cocaine despite negative consequences.
imported from: doid.owl
has cross-reference: ICD10CM:F14.1
has cross-reference: ICD9CM:305.6
has cross-reference: MESH:D019970
has cross-reference: SNOMEDCT_US_2020_03_01:78267003
has cross-reference: UMLS_CUI:C0009171
has_obo_namespace: disease_ontology
id: DOID:809

lipodystrophy
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease that is characterized by marked reduction, absence, and/or the redistribution of adipose tissue.
imported from: doid.owl
has cross-reference: ICD10CM:E88.1
has cross-reference: ICD9CM:272.6
has cross-reference: MESH:D008060
has cross-reference: NCI:C97093
has cross-reference: SNOMEDCT_US_2020_03_01:190789006
has cross-reference: UMLS_CUI:C0023787
has_obo_namespace: disease_ontology
id: DOID:811
in subset: NCIthesaurus

osteochondrosis
type: Class
subclass of: ischemic bone disease
textual definition: An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone.
imported from: doid.owl
has_alternative_id: DOID:7490
has cross-reference: ICD10CM:M92
has cross-reference: ICD10CM:M93.9
has cross-reference: ICD9CM:732.6
has cross-reference: MESH:D055034
has cross-reference: NCI:C34879
has cross-reference: SNOMEDCT_US_2020_03_01:203398006
has cross-reference: SNOMEDCT_US_2020_03_01:65477003
has cross-reference: UMLS_CUI:C0029429
has cross-reference: UMLS_CUI:C0158445
alternative_term: Epiphyseal necrosis
alternative_term: Osteochondrosis
alternative_term: apophysitis
alternative_term: epiphysitis
alternative_term: osteochondritis
alternative_term: osteochondritis juvenilis
has_obo_namespace: disease_ontology
id: DOID:8125
in subset: NCIthesaurus

septic arthritis
type: Class
subclass of: arthritis
textual definition: An arthritis that involves infection by a pathogen located_in joint.
imported from: doid.owl
has_alternative_id: DOID:10920
has_alternative_id: DOID:12314
has_alternative_id: DOID:14519
has_alternative_id: DOID:1683
has_alternative_id: DOID:2002
has_alternative_id: DOID:2003
has_alternative_id: DOID:812
has cross-reference: GARD:6781
has cross-reference: ICD10CM:M00
has cross-reference: ICD9CM:711.90
has cross-reference: ICD9CM:711.91
has cross-reference: ICD9CM:711.92
has cross-reference: ICD9CM:711.93
has cross-reference: ICD9CM:711.94
has cross-reference: ICD9CM:711.95
has cross-reference: ICD9CM:711.96
has cross-reference: ICD9CM:711.97
has cross-reference: MESH:D001170
has cross-reference: NCI:C26700
has cross-reference: SNOMEDCT_US_2020_03_01:201594004
has cross-reference: SNOMEDCT_US_2020_03_01:201595003
has cross-reference: SNOMEDCT_US_2020_03_01:201596002
has cross-reference: SNOMEDCT_US_2020_03_01:201597006
has cross-reference: SNOMEDCT_US_2020_03_01:201598001
has cross-reference: SNOMEDCT_US_2020_03_01:201599009
has cross-reference: SNOMEDCT_US_2020_03_01:372938004
has cross-reference: SNOMEDCT_US_2020_03_01:428437005
has cross-reference: UMLS_CUI:C0003869
has cross-reference: UMLS_CUI:C0157843
has cross-reference: UMLS_CUI:C0157844
has cross-reference: UMLS_CUI:C0157845
has cross-reference: UMLS_CUI:C0157846
has cross-reference: UMLS_CUI:C0157847
has cross-reference: UMLS_CUI:C0157848
has cross-reference: UMLS_CUI:C0157849
alternative_term: infectious arthritis
has_obo_namespace: disease_ontology
id: DOID:813
in subset: NCIthesaurus

gallbladder lymphoma
type: Class
subclass of: lymphoma
subclass of: gallbladder cancer
imported from: doid.owl
has cross-reference: NCI:C5734
has cross-reference: UMLS_CUI:C1333748
alternative_term: Lymphoma of the gallbladder
has_obo_namespace: disease_ontology
id: DOID:8135
in subset: NCIthesaurus

thyroid Hurthle cell adenoma
type: Class
subclass of: follicular adenoma
imported from: doid.owl
has cross-reference: NCI:C6042
has cross-reference: UMLS_CUI:C1336750
alternative_term: benign oncocytoma of the thyroid
has_obo_namespace: disease_ontology
id: DOID:8162
in subset: NCIthesaurus

gallbladder melanoma
type: Class
subclass of: melanoma
subclass of: gallbladder cancer
imported from: doid.owl
has cross-reference: NCI:C5735
has cross-reference: UMLS_CUI:C1333749
alternative_term: malignant melanoma of gallbladder
has_obo_namespace: disease_ontology
id: DOID:8167
in subset: NCIthesaurus

mediastinitis
type: Class
subclass of: connective tissue disease
textual definition: A connective tissue disease characterized by inflammation located_in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.
imported from: doid.owl
has cross-reference: ICD10CM:J98.51
has cross-reference: ICD9CM:519.2
has cross-reference: MESH:D008480
has cross-reference: NCI:C26827
has cross-reference: SNOMEDCT_US_2020_03_01:47597000
has cross-reference: UMLS_CUI:C0025064
has_obo_namespace: disease_ontology
id: DOID:819
in subset: NCIthesaurus

myocarditis
type: Class
subclass of: extrinsic cardiomyopathy
textual definition: An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.
imported from: doid.owl
has cross-reference: GARD:7137
has cross-reference: ICD10CM:I51.4
has cross-reference: ICD9CM:429.0
has cross-reference: KEGG:05416
has cross-reference: MESH:D009205
has cross-reference: NCI:C34831
has cross-reference: SNOMEDCT_US_2020_03_01:50920009
has cross-reference: UMLS_CUI:C0027059
alternative_term: Myocardial inflammation
has_obo_namespace: disease_ontology
id: DOID:820
in subset: NCIthesaurus

tertiary syphilis
type: Class
subclass of: syphilis
textual definition: A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems.
imported from: doid.owl
has cross-reference: ICD10CM:A52
has cross-reference: ICD9CM:097.0
has cross-reference: MESH:C536774
has cross-reference: NCI:C128414
has cross-reference: SNOMEDCT_US_2020_03_01:72083004
has cross-reference: UMLS_CUI:C0153188
alternative_term: late syphilis
has_obo_namespace: disease_ontology
id: DOID:8200
in subset: NCIthesaurus
in subset: gram-negative bacterial infectious disease
in subset: sexually transmitted infectious disease

periapical periodontitis
type: Class
subclass of: periodontitis
imported from: doid.owl
has cross-reference: ICD10CM:K04.5
has cross-reference: MESH:D010485
has cross-reference: SNOMEDCT_US_2020_03_01:39273001
has cross-reference: UMLS_CUI:C0031030
alternative_term: Apical periodontitis
has_obo_namespace: disease_ontology
id: DOID:823

periodontitis
type: Class
subclass of: periodontal disease
imported from: doid.owl
has cross-reference: EFO:0000649
has cross-reference: ICD10CM:K05.3
has cross-reference: MESH:D010518
has cross-reference: NCI:C34918
has cross-reference: SNOMEDCT_US_2020_03_01:266491004
has cross-reference: UMLS_CUI:C0031099
alternative_term: chronic pericementitis
has_obo_namespace: disease_ontology
id: DOID:824
in subset: NCIthesaurus

peritonitis
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.
imported from: doid.owl
has_alternative_id: DOID:8694
has_alternative_id: DOID:8863
has_alternative_id: DOID:9233
has cross-reference: ICD9CM:567.8
has cross-reference: SNOMEDCT_US_2020_03_01:197183001
has cross-reference: UMLS_CUI:C0029823
alternative_term: Retractile mesenteritis
alternative_term: acute generalized peritonitis
alternative_term: primary bacterial peritonitis
alternative_term: sclerosing mesenteritis
has_obo_namespace: disease_ontology
id: DOID:8283

scabies
type: Class
subclass of: mite infestation
textual definition: A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.
imported from: doid.owl
has cross-reference: ICD10CM:B86
has cross-reference: ICD9CM:133.0
has cross-reference: MESH:D012532
has cross-reference: NCI:C34998
has cross-reference: SNOMEDCT_US_2020_03_01:266224002
has cross-reference: UMLS_CUI:C0036262
alternative_term: Infestation by Sarcoptes scabiei
alternative_term: Infestation by Sarcoptes scabiei var hominis
alternative_term: Sarcoptic itch
has_obo_namespace: disease_ontology
id: DOID:8295
in subset: NCIthesaurus

cataract
type: Class
subclass of: monogenic disease
subclass of: lens disease
textual definition: A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.
imported from: doid.owl
has cross-reference: ICD10CM:H26
has cross-reference: ICD9CM:366.8
has cross-reference: OMIM:601371
has cross-reference: OMIM:PS116200
has cross-reference: SNOMEDCT_US_2020_03_01:193620000
has cross-reference: UMLS_CUI:C0029531
has_obo_namespace: disease_ontology
id: DOID:83
comment: Xref MGI.

mixed endometrial stromal and smooth muscle tumor
type: Class
subclass of: DOID 9460
textual definition: A uterine corpus cancer that has_material_basis_in endometrial stroma and smooth muscle cells.
imported from: doid.owl
has cross-reference: NCI:C40178
has cross-reference: UMLS_CUI:C1513364
alternative_term: Stromomyoma
has_obo_namespace: disease_ontology
id: DOID:8302
in subset: NCIthesaurus

auditory system cancer
type: Class
subclass of: sensory system cancer
subclass of: auditory system disease
textual definition: An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs.
imported from: doid.owl
has cross-reference: MESH:D004428
has cross-reference: NCI:C3000
has cross-reference: SNOMEDCT_US_2020_03_01:363228008
has cross-reference: UMLS_CUI:C0013449
has_obo_namespace: disease_ontology
id: DOID:833
in subset: NCIthesaurus

appendicitis
type: Class
subclass of: cecal disease
textual definition: A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.
imported from: doid.owl
has_alternative_id: DOID:10275
has_alternative_id: DOID:10276
has_alternative_id: DOID:10947
has cross-reference: ICD10CM:K37
has cross-reference: ICD9CM:540-543.99
has cross-reference: MESH:D001064
has cross-reference: NCI:C35145
has cross-reference: SNOMEDCT_US_2020_03_01:155729003
has cross-reference: UMLS_CUI:C0003615
alternative_term: acute appendicitis
alternative_term: acute appendicitis with generalized peritonitis
alternative_term: acute appendicitis with peritoneal abscess
has_obo_namespace: disease_ontology
id: DOID:8337
in subset: NCIthesaurus

complement component 3 deficiency
type: Class
subclass of: complement deficiency
textual definition: A complement deficiency that is characterized by deficiency of complement component 3 that increases susceptibility to infection and autoimmune diseases and has_material_basis_in autosomal recessive inheritance of mutation in the C3 gene on chromosome 19p13.3, has_symptom recurrent bacterial infections.
imported from: doid.owl
has cross-reference: NCI:C9468
has cross-reference: OMIM:613779
has cross-reference: ORDO:280133
has cross-reference: SNOMEDCT_US_2020_03_01:771443008
has cross-reference: UMLS_CUI:C1332655
alternative_term: C3 deficiency
has_obo_namespace: disease_ontology
id: DOID:8354
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI.

osteoarthritis
type: Class
subclass of: arthritis
textual definition: An arthritis that has_material_basis_in worn out cartilage located_in joint.
imported from: doid.owl
has cross-reference: EFO:0002506
has cross-reference: ICD9CM:715.3
has cross-reference: UMLS_CUI:C0157946
alternative_term: Osteoarthrosis and allied disorder
alternative_term: degenerative arthritis
alternative_term: degenerative joint disease
alternative_term: hypertrophic arthritis
alternative_term: osteoarthrosis
has_obo_namespace: disease_ontology
id: DOID:8398
comment: Xref MGI.

osteochondritis dissecans
type: Class
subclass of: ischemic bone disease
textual definition: An ischemic bone disease that results_in necrosis located_in epiphysis.
imported from: doid.owl
has_alternative_id: DOID:87
has cross-reference: GARD:12703
has cross-reference: ICD10CM:M93.2
has cross-reference: ICD10CM:M93.9
has cross-reference: ICD9CM:732.7
has cross-reference: MESH:D010007
has cross-reference: MESH:D010008
has cross-reference: NCI:C34877
has cross-reference: NCI:C34878
has cross-reference: OMIM:165800
has cross-reference: SNOMEDCT_US_2020_03_01:156821002
has cross-reference: SNOMEDCT_US_2020_03_01:70736000
has cross-reference: UMLS_CUI:C0029420
has cross-reference: UMLS_CUI:C0029421
alternative_term: OCD
has_obo_namespace: disease_ontology
id: DOID:84
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

extrinsic allergic alveolitis
type: Class
subclass of: allergic disease
subclass of: interstitial lung disease
textual definition: An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.
imported from: doid.owl
has_alternative_id: DOID:2707
has cross-reference: GARD:12
has cross-reference: ICD10CM:J67.9
has cross-reference: ICD9CM:495
has cross-reference: MESH:D000542
has cross-reference: NCI:C34369
has cross-reference: SNOMEDCT_US_2020_03_01:155581001
has cross-reference: UMLS_CUI:C0002390
alternative_term: alveolitis
alternative_term: hypersensitivity pneumonitis
has_obo_namespace: disease_ontology
id: DOID:841
in subset: NCIthesaurus

kidney angiomyolipoma
type: Class
subclass of: kidney benign neoplasm
imported from: doid.owl
has cross-reference: NCI:C3888
has cross-reference: SNOMEDCT_US_2020_03_01:254921004
has cross-reference: UMLS_CUI:C0241961
alternative_term: Angiomyolipoma of kidney
alternative_term: renal Angiomyolipoma
has_obo_namespace: disease_ontology
id: DOID:8411
in subset: NCIthesaurus

congenital fibrosarcoma
type: Class
subclass of: physical disorder
subclass of: pediatric fibrosarcoma
imported from: doid.owl
has cross-reference: NCI:C4244
has cross-reference: SNOMEDCT_US_2020_03_01:403996004
has cross-reference: UMLS_CUI:C0334459
alternative_term: Infantile fibrosarcoma
has_obo_namespace: disease_ontology
id: DOID:8418
in subset: NCIthesaurus

polycythemia
type: Class
subclass of: bone marrow disease
textual definition: A bone marrow disease characterized by an increased number of red blood cells in the bloodstream resulting in thicker blood and reduced blood flow.
imported from: doid.owl
has cross-reference: ICD10CM:D75.1
has cross-reference: MESH:D011086
has cross-reference: NCI:C26863
has cross-reference: SNOMEDCT_US_2020_03_01:127062003
has cross-reference: UMLS_CUI:C0032461
alternative_term: Erythrocythemia
has_obo_namespace: disease_ontology
id: DOID:8432
in subset: NCIthesaurus

intestinal obstruction
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: ICD10CM:K56.609
has cross-reference: ICD9CM:560.9
has cross-reference: MESH:D007415
has cross-reference: NCI:C9175
has cross-reference: SNOMEDCT_US_2020_03_01:81060008
has cross-reference: UMLS_CUI:C0021843
has_obo_namespace: disease_ontology
id: DOID:8437
in subset: NCIthesaurus

afferent loop syndrome
type: Class
subclass of: postgastrectomy syndrome
textual definition: A postgastrectomy syndrome that is characterized by obstruction of the afferent loop that arises after gastric surgery with gastrojejunostomy reconstruction.
imported from: doid.owl
has cross-reference: MESH:D000343
has cross-reference: SNOMEDCT_US_2020_03_01:20813000
has cross-reference: UMLS_CUI:C0001727
alternative_term: Afferent limb syndrome
has_obo_namespace: disease_ontology
id: DOID:8438

postgastrectomy syndrome
type: Class
subclass of: functional gastric disease
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: ICD10CM:K91.1
has cross-reference: ICD9CM:564.2
has cross-reference: MESH:D011178
has cross-reference: SNOMEDCT_US_2020_03_01:266527005
has cross-reference: UMLS_CUI:C0032763
alternative_term: Postgastric surgery syndrome
has_obo_namespace: disease_ontology
id: DOID:8439

ileus
type: Class
subclass of: intestinal obstruction
imported from: doid.owl
has cross-reference: MESH:D045823
has cross-reference: NCI:C37979
has cross-reference: SNOMEDCT_US_2020_03_01:278524008
has cross-reference: UMLS_CUI:C1258215
alternative_term: Ileus of intestine
has_obo_namespace: disease_ontology
id: DOID:8440
in subset: NCIthesaurus

brachial plexus lesion
type: Class
subclass of: brachial plexus neuropathy
textual definition: A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.
imported from: doid.owl
has cross-reference: ICD9CM:353.0
has cross-reference: SNOMEDCT_US_2020_03_01:3548001
has cross-reference: UMLS_CUI:C0006091
alternative_term: Brachial plexus lesions
has_obo_namespace: disease_ontology
id: DOID:8443

intestinal volvulus
type: Class
subclass of: intestinal obstruction
textual definition: An intestinal obstruction characterized by abnormal rotation of the intestines.
imported from: doid.owl
has cross-reference: ICD10CM:K56.2
has cross-reference: ICD9CM:560.2
has cross-reference: MESH:D045822
has cross-reference: NCI:C98963
has cross-reference: OMIM:193250
has cross-reference: SNOMEDCT_US_2020_03_01:9707006
has cross-reference: UMLS_CUI:C0042961
alternative_term: Twist of intestine, bowel, or colon
alternative_term: Volvulus
alternative_term: familial intestinal malrotation
alternative_term: volvulus of midgut
has_obo_namespace: disease_ontology
id: DOID:8445
in subset: NCIthesaurus

intussusception
type: Class
subclass of: intestinal obstruction
imported from: doid.owl
has cross-reference: ICD10CM:K56.1
has cross-reference: ICD9CM:560.0
has cross-reference: MESH:D007443
has cross-reference: NCI:C113484
has cross-reference: OMIM:147710
has cross-reference: SNOMEDCT_US_2020_03_01:155772009
has cross-reference: UMLS_CUI:C0021933
alternative_term: Intussusception
alternative_term: Intussusception of intestine
alternative_term: Invagination of intestine or colon
has_obo_namespace: disease_ontology
id: DOID:8446
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

cyclothymic disorder
type: Class
subclass of: bipolar disorder
textual definition: A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes.
imported from: doid.owl
has cross-reference: ICD10CM:F34.0
has cross-reference: ICD9CM:301.13
has cross-reference: MESH:D003527
has cross-reference: SNOMEDCT_US_2020_03_01:191754000
has cross-reference: UMLS_CUI:C0010598
alternative_term: Affective personality disorder
alternative_term: Cycloid personality
alternative_term: Cyclothymia
alternative_term: Cyclothymic personality
has_obo_namespace: disease_ontology
id: DOID:845

riboflavin deficiency
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by stomatitis, cheilosis, glossitis, conjunctivitis, and anemia, develops_from vitamin B2 (riboflavin) deficiency, has_symptom red chapped lips, painful swollen tongue, sore throat, blurred vision, and fatigue, and has_material_basis_in inadequate intake, endocrine disorder, liver disorder, alcoholism, and dialysis.
imported from: doid.owl
has cross-reference: ICD10CM:E53.0
has cross-reference: ICD9CM:266.0
has cross-reference: MESH:D012257
has cross-reference: SNOMEDCT_US_2020_03_01:20307000
has cross-reference: UMLS_CUI:C0035528
alternative_term: ariboflavinosis
alternative_term: vitamin B2 deficiency
has_obo_namespace: disease_ontology
id: DOID:8454

pellagra
type: Class
subclass of: nutritional deficiency disease
textual definition: A nutritional deficiency disease that is characterized by deficiency of niacin (vitamin B3), has_symptom gastrointestinal disturbance, anorexia, diarrhea, dementia, hallucinations, depression, psychosis, and/or non-specific skin changes, and has_material_basis_in deficiency of niacin, often from inadequate diet, malabsorption, or medication side effects.
imported from: doid.owl
has cross-reference: GARD:10014
has cross-reference: ICD9CM:265.2
has cross-reference: MESH:D010383
has cross-reference: SNOMEDCT_US_2020_03_01:267491008
has cross-reference: UMLS_CUI:C0030783
alternative_term: Niacin deficiency
alternative_term: Niacin-tryptophan deficiency
alternative_term: Pellagra
has_obo_namespace: disease_ontology
id: DOID:8457

Aicardi syndrome
type: Class
subclass of: syndrome
textual definition: A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.
imported from: doid.owl
has cross-reference: GARD:5764
has cross-reference: MESH:D058540
has cross-reference: NCI:C35256
has cross-reference: OMIM:304050
has cross-reference: ORDO:50
has cross-reference: SNOMEDCT_US_2020_03_01:80651009
has cross-reference: UMLS_CUI:C0175713
has_obo_namespace: disease_ontology
id: DOID:8461
in subset: DO rare slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

corneal ulcer
type: Class
subclass of: keratitis
imported from: doid.owl
has cross-reference: ICD10CM:H16.0
has cross-reference: ICD9CM:370.0
has cross-reference: MESH:D003320
has cross-reference: NCI:C50515
has cross-reference: SNOMEDCT_US_2020_03_01:193758008
has cross-reference: UMLS_CUI:C0010043
has_obo_namespace: disease_ontology
id: DOID:8463
in subset: NCIthesaurus

retinoschisis
type: Class
subclass of: retinal degeneration
imported from: doid.owl
has cross-reference: ICD10CM:H33.10
has cross-reference: ICD9CM:361.10
has cross-reference: MESH:D041441
has cross-reference: NCI:C85046
has cross-reference: SNOMEDCT_US_2020_03_01:389992006
has cross-reference: UMLS_CUI:C0152439
has_obo_namespace: disease_ontology
id: DOID:8465
in subset: NCIthesaurus

retinal degeneration
type: Class
subclass of: retinal disease
subclass of: DOID 9799
textual definition: A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina.
imported from: doid.owl
has cross-reference: MESH:D012162
has cross-reference: NCI:C34979
has cross-reference: SNOMEDCT_US_2020_03_01:95695004
has cross-reference: UMLS_CUI:C0035304
alternative_term: degeneration of retina
has_obo_namespace: disease_ontology
id: DOID:8466
in subset: DO FlyBase slim
in subset: NCIthesaurus

influenza
type: Class
subclass of: respiratory system disease
subclass of: DOID 934
textual definition: A viral infectious disease that results in infection, located in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.
imported from: doid.owl
has_alternative_id: DOID:8468
has cross-reference: ICD10CM:J11.1
has cross-reference: ICD9CM:487
has cross-reference: MESH:D007251
has cross-reference: NCI:C53482
has cross-reference: SNOMEDCT_US_2020_03_01:155559006
has cross-reference: UMLS_CUI:C0021400
alternative_term: Influenza with non-respiratory manifestation
alternative_term: Influenza with other manifestations
alternative_term: flu
alternative_term: influenza with non-respiratory manifestation
has_obo_namespace: disease_ontology
id: DOID:8469
in subset: NCIthesaurus

localized scleroderma
type: Class
subclass of: scleroderma
imported from: doid.owl
has cross-reference: GARD:7058
has cross-reference: ICD10CM:L94.0
has cross-reference: ICD9CM:701.0
has cross-reference: MESH:D012594
has cross-reference: NCI:C72069
has cross-reference: SNOMEDCT_US_2020_03_01:90424004
has cross-reference: UMLS_CUI:C0036420
alternative_term: Morphea
alternative_term: Scleroderma, circumscribed or localised
alternative_term: Scleroderma, circumscribed or localized
alternative_term: circumscribed scleroderma
alternative_term: localised morphea
alternative_term: localised morphoea
alternative_term: localised scleroderma
alternative_term: localized morphea
has_obo_namespace: disease_ontology
id: DOID:8472
in subset: NCIthesaurus

Whipple disease
type: Class
subclass of: intestinal disease
imported from: doid.owl
has cross-reference: GARD:7889
has cross-reference: ICD10CM:K90.81
has cross-reference: ICD9CM:040.2
has cross-reference: MESH:D008061
has cross-reference: NCI:C85228
has cross-reference: SNOMEDCT_US_2020_03_01:41545003
has cross-reference: UMLS_CUI:C0023788
alternative_term: Whipple's disease
alternative_term: intestinal lipodystrophy
has_obo_namespace: disease_ontology
id: DOID:8476
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

actinomycosis
type: Class
subclass of: commensal bacterial infectious disease
subclass of: respiratory system disease
textual definition: A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.
imported from: doid.owl
has_alternative_id: DOID:0050000
has_alternative_id: DOID:13079
has cross-reference: GARD:5728
has cross-reference: ICD10CM:A42
has cross-reference: ICD9CM:039.9
has cross-reference: MESH:D000196
has cross-reference: NCI:C34350
has cross-reference: SNOMEDCT_US_2020_03_01:50508009
has cross-reference: UMLS_CUI:C0001261
alternative_term: Actinomycotic madura foot
alternative_term: Actinomycotic mycetema
alternative_term: Actinomycotic mycetoma of foot
alternative_term: Madura foot due to Actinomadura
alternative_term: actinomycotic infection
has_obo_namespace: disease_ontology
has_related_synonym: actinomycetoma
has_related_synonym: boil
id: DOID:8478
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

arthritis
type: Class
subclass of: bone inflammation disease
textual definition: A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint.
imported from: doid.owl
has cross-reference: ICD10CM:M19.90
has cross-reference: MESH:D001168
has cross-reference: NCI:C2883
has cross-reference: SNOMEDCT_US_2020_03_01:372091005
has cross-reference: UMLS_CUI:C0003864
alternative_term: Inflammatory disorder of joint
has_obo_namespace: disease_ontology
id: DOID:848
in subset: NCIthesaurus

rheumatic myocarditis
type: Class
subclass of: bacterial infectious disease
subclass of: myocarditis
imported from: doid.owl
has_alternative_id: DOID:14025
has_alternative_id: DOID:14036
has cross-reference: ICD10CM:I01.9
has cross-reference: ICD10CM:M05.3
has cross-reference: ICD9CM:391.9
has cross-reference: ICD9CM:398.0
has cross-reference: NCI:C34985
has cross-reference: SNOMEDCT_US_2020_03_01:195136004
has cross-reference: SNOMEDCT_US_2020_03_01:8805001
has cross-reference: UMLS_CUI:C0035440
has cross-reference: UMLS_CUI:C0489959
alternative_term: Rheumatic degeneration of myocardium
alternative_term: Rheumatic fever with myocarditis
alternative_term: Rheumatic myocarditis
alternative_term: Rheumatoid myocarditis
alternative_term: active rheumatic fever with myocarditis
alternative_term: acute Rheumatic Myocarditis
alternative_term: acute rheumatic carditis
alternative_term: acute rheumatic myocarditis
has_obo_namespace: disease_ontology
id: DOID:8481
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

retinal artery occlusion
type: Class
subclass of: artery disease
subclass of: retinal vascular occlusion
imported from: doid.owl
has cross-reference: MESH:D015356
has cross-reference: NCI:C34978
has cross-reference: SNOMEDCT_US_2020_03_01:232035005
has cross-reference: UMLS_CUI:C0035302
alternative_term: Retinal artery occlusion
has_obo_namespace: disease_ontology
id: DOID:8483
in subset: NCIthesaurus

polyhydramnios
type: Class
subclass of: placenta disease
textual definition: A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.
imported from: doid.owl
has cross-reference: ICD10CM:O40
has cross-reference: ICD9CM:657.0
has cross-reference: MESH:D006831
has cross-reference: NCI:C92848
has cross-reference: SNOMEDCT_US_2020_03_01:157052008
has cross-reference: UMLS_CUI:C0020224
has_obo_namespace: disease_ontology
id: DOID:8488
in subset: NCIthesaurus

hereditary night blindness
type: Class
subclass of: night blindness
imported from: doid.owl
has cross-reference: ICD10CM:H53.63
has cross-reference: ICD9CM:368.61
has cross-reference: MESH:C537743
has cross-reference: SNOMEDCT_US_2020_03_01:193687000
has cross-reference: UMLS_CUI:C1306122
alternative_term: Congenital night blindness
has_obo_namespace: disease_ontology
id: DOID:8498
comment: OMIM mapping confirmed by DO. [SN].

night blindness
type: Class
subclass of: retinal disease
textual definition: A retinal disease that is characterized by difficulty or the inability to see in relatively low light.
imported from: doid.owl
has cross-reference: ICD10CM:H53.6
has cross-reference: ICD9CM:368.6
has cross-reference: MESH:D009755
has cross-reference: NCI:C34850
has cross-reference: SNOMEDCT_US_2020_03_01:75390007
has cross-reference: UMLS_CUI:C0028077
alternative_term: nyctalopia
has_obo_namespace: disease_ontology
id: DOID:8499
in subset: NCIthesaurus

lung disease
type: Class
subclass of: lower respiratory tract disease
textual definition: A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide.
imported from: doid.owl
has_alternative_id: DOID:11894
has_alternative_id: DOID:11895
has_alternative_id: DOID:29
has_alternative_id: DOID:766
has cross-reference: ICD10CM:J98.4
has cross-reference: MESH:D008171
has cross-reference: NCI:C3198
has cross-reference: SNOMEDCT_US_2020_03_01:266374002
has cross-reference: UMLS_CUI:C0024115
has_obo_namespace: disease_ontology
id: DOID:850
in subset: NCIthesaurus
comment: Updating out dated CUI and removing lung abscess as a synonym.

fundus dystrophy
type: Class
subclass of: eye disease
imported from: doid.owl
has cross-reference: MESH:D058499
has cross-reference: NCI:C35625
has cross-reference: SNOMEDCT_US_2020_03_01:314407005
has cross-reference: UMLS_CUI:C0854723
alternative_term: Retinal Dystrophy
has_obo_namespace: disease_ontology
id: DOID:8501
in subset: NCIthesaurus

bullous skin disease
type: Class
subclass of: dermatitis
subclass of: connective tissue disease
textual definition: An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested.
imported from: doid.owl
has cross-reference: ICD9CM:694.8
has cross-reference: SNOMEDCT_US_2020_03_01:200916004
has cross-reference: UMLS_CUI:C0079957
has_obo_namespace: disease_ontology
id: DOID:8502

impetigo
type: Class
subclass of: pyoderma
textual definition: A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.
imported from: doid.owl
has cross-reference: ICD10CM:L01.0
has cross-reference: ICD9CM:684
has cross-reference: MESH:D007169
has cross-reference: NCI:C99088
has cross-reference: SNOMEDCT_US_2020_03_01:156319000
has cross-reference: UMLS_CUI:C0021099
has_obo_namespace: disease_ontology
id: DOID:8504
in subset: NCIthesaurus
in subset: gram-positive bacterial infectious disease

dermatitis herpetiformis
type: Class
subclass of: autoimmune disease of skin and connective tissue
subclass of: bullous skin disease
imported from: doid.owl
has cross-reference: GARD:1917
has cross-reference: ICD10CM:L13.0
has cross-reference: ICD9CM:694.0
has cross-reference: MESH:D003874
has cross-reference: NCI:C26742
has cross-reference: SNOMEDCT_US_2020_03_01:200899006
has cross-reference: UMLS_CUI:C0011608
alternative_term: Dermatitis herpetiformis
alternative_term: Dermatosis herpetiformis
alternative_term: Duhring's disease
has_obo_namespace: disease_ontology
id: DOID:8505
in subset: NCIthesaurus

bullous pemphigoid
type: Class
subclass of: autoimmune disease of skin and connective tissue
textual definition: An autoimmune disease of skin and connective tissue characterized by large blisters.
imported from: doid.owl
has cross-reference: GARD:5972
has cross-reference: ICD10CM:L12.0
has cross-reference: ICD9CM:694.5
has cross-reference: MESH:D010391
has cross-reference: NCI:C84389
has cross-reference: SNOMEDCT_US_2020_03_01:77090002
has cross-reference: UMLS_CUI:C0030805
alternative_term: Bullous pemphigoid
has_obo_namespace: disease_ontology
id: DOID:8506
in subset: NCIthesaurus

subcorneal pustular dermatosis
type: Class
subclass of: bullous skin disease
imported from: doid.owl
has cross-reference: ICD10CM:L13.1
has cross-reference: ICD9CM:694.1
has cross-reference: MESH:D012872
has cross-reference: SNOMEDCT_US_2020_03_01:25147002
has cross-reference: UMLS_CUI:C0600336
alternative_term: Sneddon-Wilkinson disease or syndrome
alternative_term: Subcorneal pustular dermatosis
has_obo_namespace: disease_ontology
id: DOID:8508

acute pulmonary heart disease
type: Class
subclass of: Cor pulmonale
imported from: doid.owl
has cross-reference: ICD9CM:415
has cross-reference: SNOMEDCT_US_2020_03_01:155324005
has cross-reference: UMLS_CUI:C0155671
has_obo_namespace: disease_ontology
id: DOID:8514

Cor pulmonale
type: Class
subclass of: congestive heart failure
textual definition: A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.
imported from: doid.owl
has cross-reference: ICD10CM:I27.81
has cross-reference: MESH:D011660
has cross-reference: SNOMEDCT_US_2020_03_01:83291003
has cross-reference: UMLS_CUI:C0034072
alternative_term: cardiopulmonary disease
alternative_term: pulmonary heart disease
has_obo_namespace: disease_ontology
id: DOID:8515

acute cor pulmonale
type: Class
subclass of: acute pulmonary heart disease
imported from: doid.owl
has cross-reference: ICD10CM:I26.09
has cross-reference: ICD9CM:415.0
has cross-reference: SNOMEDCT_US_2020_03_01:155325006
has cross-reference: UMLS_CUI:C0155672
has_obo_namespace: disease_ontology
id: DOID:8517