--- name: mage-antibody-generator description: Ab seq forge keywords: - antibody - antigen - FASTA - generation - validation measurable_outcome: Generate the requested number of antibody sequences (default ≥5) with metadata (model checkpoint, seed) and deliver FASTA files within 10 minutes. license: MIT metadata: author: MAGE Team version: "1.0.0" compatibility: - system: Python 3.9+ / GPU allowed-tools: - run_shell_command - read_file --- # MAGE (Monoclonal Antibody Generator) Run the MAGE antibody generation workflow to propose antigen-conditioned antibody sequences for downstream structural validation. ## Workflow 1. **Prep env:** `cd repo` and install dependencies, then point to GPU if available. 2. **Run generator:** `python generate_antibodies.py --antigen_sequence --num_candidates N --output_dir ./results`. 3. **Collect outputs:** Provide FASTA paths + metadata, optionally translate into JSON manifest. 4. **Recommend validation:** Suggest AlphaFold/Rosetta checks and wet-lab follow-up. ## Guardrails - Never imply binding efficacy without structural/experimental confirmation. - Track model version + seeds to ensure reproducibility. - Encourage downstream filtering (liability motifs, developability metrics). ## References - Source instructions in `README.md` and repo scripts.