Alex Ade
Yuqin Liu
Alexander Diehl
Allen Xiang
Asiyah Yu Lin
Caty Chung
Daniel Cooper
Helen Parkinson
Hiroshi Masuya
Hongjie Pan
James Malone
Jiangan Xie
Jie Zheng
Matthew Brush
Sirarat Sarntivijai
Stefanie Seltmann
Stephan Schurer
Uma Vempati
Xiaolin Yang
Yongqun "Oliver" He (YH)
Yue Liu
The Cell Line Ontology (CLO) is a community-based ontology of cell lines. The CLO is developed to unify publicly available cell line entry data from multiple sources to a standardized logically defined format based on consensus design patterns.
OWL-DL
An ontology for the domain of cell lines and cell line cells
CLO: Cell Line Ontology
Citation: Sarntivijai S, Lin Y, Xiang Z, Meehan TF, Diehl AD, Vempati UD, Schürer TC, Pang C, Malone J, Parkinson H, Liu Y, Takatsuki T, Saijo K, Masuya H, Nakamura Y, Brush MH, Haendel MA, Zheng J, Stoeckert CJ, Peters B, Mungall CJ, Carey TE, States DJ, Athey BD, He Y. CLO: The Cell Line Ontology. Journal of Biomedical Semantics. 2014, 5:37. doi:10.1186/2041-1480-5-37. PMID: 25852852. PMCID: PMC4387853.
An annotation property that represents an ID used in the NIH LINCS project.
LINCS ID
An annotation property that specifies an STR profile of a cell line cell.
STR profile
An annotation property that represents a PubMed BioAssay Identifier accession number.
PubChem AID
An annotation property that describes the information of a problematic cell line.
problematic cell line annotation
An annotation property that describes the origin of a cell line.
cell line cell origin
An annotation property that describes the features of a cell line and cell line cell.
cell line cell feature
An annotation property that describes known mutation(s) about a cell.
Known mutation annotation
Cell culture condition
editor preferred term
The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
PERSON:Daniel Schober
example of usage
A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.
in branch
An annotation property indicating which module the terms belong to. This is currently experimental and not implemented yet.
has curation status
PERSON:Alan Ruttenberg
PERSON:Bill Bug
PERSON:Melanie Courtot
definition
The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
editor note
An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
term editor
Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
alternative label
A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like.
Consider re-defing to: An alternative name for a class or property which can mean the same thing as the preferred name (semantically equivalent, narrow, broad or related).
definition source
Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
has obsolescence reason
Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification.
curator note
An administrative note of use for a curator but of no use for a user
term tracker item
the URL for an ontology term tracker issue, such as https://github.com/monarch-initiative/mondo/issues/7588
A URL for a request or discussion of an ontology term.
Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
The 'tracker item' can associate a tracker with a specific ontology term.
ontology term requester
The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition.
The 'term requester' can credit the person, organization or project who request the ontology term.
is denotator type
Relates an class defined in an ontology, to the type of it's denotator
In OWL 2 add AnnotationPropertyRange('is denotator type' 'denotator type')
Alan Ruttenberg
imported from
For external terms/classes, the ontology from which the term was imported
expand expression to
ObjectProperty: RO_0002104 Label: has plasma membrane part Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones
Chris Mungall
expand assertion to
ObjectProperty: RO??? Label: spatially disjoint from Annotations: expand_assertion_to "DisjointClasses: (http://purl.obolibrary.org/obo/BFO_0000051 some ?X) (http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
A macro expansion tag applied to an annotation property which can be expanded into a more detailed axiom.
first order logic expression
antisymmetric property
part_of antisymmetric property xsd:true
Use boolean value xsd:true to indicate that the property is an antisymmetric property
OBO foundry unique label
An alternative name for a class or property which is unique across the OBO Foundry.
The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools .
PERSON:Bjoern Peters
PERSON:Chris Mungall
GROUP:OBO Foundry <http://obofoundry.org/>
has ID digit count
Ontology: <http://purl.obolibrary.org/obo/ro/idrange/> Annotations: 'has ID prefix': "http://purl.obolibrary.org/obo/RO_" 'has ID digit count' : 7, rdfs:label "RO id policy" 'has ID policy for': "RO"
Relates an ontology used to record id policy to the number of digits in the URI. The URI is: the 'has ID prefix" annotation property value concatenated with an integer in the id range (left padded with "0"s to make this many digits)
Person:Alan Ruttenberg
has ID range allocated
Datatype: idrange:1 Annotations: 'has ID range allocated to': "Chris Mungall" EquivalentTo: xsd:integer[> 2151 , <= 2300]
Relates a datatype that encodes a range of integers to the name of the person or organization who can use those ids constructed in that range to define new terms
has ID range allocated to
has ID policy for
Relating an ontology used to record id policy to the ontology namespace whose policy it manages
has ID prefix
Relates an ontology used to record id policy to a prefix concatenated with an integer in the id range (left padded with "0"s to make this many digits) to construct an ID for a term being created.
elucidation
person:Alan Ruttenberg
Person:Barry Smith
Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms
has associated axiom(nl)
An axiom associated with a term expressed using natural language
has associated axiom(fol)
An axiom expressed in first order logic using CLIF syntax
is allocated id range
Relates an ontology IRI to an (inclusive) range of IRIs in an OBO name space. The range is give as, e.g. "IAO_0020000-IAO_0020999"
Add as annotation triples in the granting ontology
has ontology root term
Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root.
Nicolas Matentzoglu
may be identical to
A annotation relationship between two terms in an ontology that may refer to the same (natural) type but where more evidence is required before terms are merged.
David Osumi-Sutherland
VFB
Edges asserting this should be annotated with to record evidence supporting the assertion and its provenance.
scheduled for obsoletion on or after
Used when the class or object is scheduled for obsoletion/deprecation on or after a particular date.
Chris Mungall, Jie Zheng
GO ontology
has axiom id
A URI that is intended to be unique label for an axiom used for tracking change to the ontology. For an axiom expressed in different languages, each expression is given the same URI
has axiom label
term replaced by
Use on obsolete terms, relating the term to another term that can be used as a substitute
An alternative term used by the IEDB.
PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters
This is an annotation used on an object property to indicate a logical characterstic beyond what is possible in OWL.
logical characteristic of object property
'part disjoint with' 'defined by construct' """ PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX : <http://example.org/ CONSTRUCT { [ a owl:Restriction ; owl:onProperty :part_of ; owl:someValuesFrom ?a ; owl:disjointWith [ a owl:Restriction ; owl:onProperty :part_of ; owl:someValuesFrom ?b ] ] } WHERE { ?a :part_disjoint_with ?b . }
Links an annotation property to a SPARQL CONSTRUCT query which is meant to provide semantics for a shortcut relation.
The property is intended to be used exclusively on synonym assertions, to express that the synonym in question is the preference of a specific community. For example, one community may prefer to say call a disease "A" and another one "B" (but they are the same thing).
A provenance property that denotes a synonym to be the preferred one for a specific community.
CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)
A synonym type for describing abbreviations or initialisms
A synonym type for describing ambiguous synonyms
A synonym type for describing dubious synonyms
EFO:0006346 (severe cutaneous adverse reaction) has an exact synonym (scar), which is of the type OMO:0003003 (layperson synonym)
A synonym type for describing layperson or colloquial synonyms
CHEBI:23367 (molecular entity) has an exact synonym (molecular entities), which is of the type OMO:0003004 (plural form)
A synonym type for describing pluralization synonyms
CHEBI:16189 (sulfate) has an exact synonym (sulphate), which is of the type OMO:0003005 (UK spelling synonym)
A synonym type for describing UK spelling variants
A synonym type for misnomers, i.e., a synonym that is not technically correct but is commonly used anyway
MAPT, the gene that encodes the Tau protein, has a previous name DDPAC. Note: in this case, the name type is more specifically the gene symbol.
A synonym type for names that have been used as primary labels in the past.
The legal name for Harvard University (https://ror.org/03vek6s52) is President and Fellows of Harvard College
A synonym type for the legal entity name
CHEBI:46195 has been assigned the english International Nonproproprietary Name (INN) "paracetamol". In some cases such as this one, the INN might be the same as the ontology's primary label
The International Nonproprietary Name (INN) is a standardize name for a pharmaceutical drug or active ingredient issued by the World Health Organization (WHO) meant to address the issues with country- or language-specific brand names. These are issued in several languages, including English, Latin, French, Russian, Spanish, Arabic, and Chinese.
nasopharynx (UBERON:0001728) has the latin name "pars nasalis pharyngis
A synonym type for describing Latin term synonyms.
NASA is an word acronym for the US National Aeronautics and Space Administration because the acronym is pronounced. FBI is an initialism (also known as alphabetism) for the US Federal Bureau of Investigation since the letters are pronounced one at a time. JPEG is an acronym for Joint Photographic Experts Group but does not count as a word acronym nor an initialism since it is mixed how it is pronounced.
A synonym type for describing abbreviations that are a part of the full name's words, such as initialisms or alphabetisms.
The Developing Mouse Brain Atlas Ontology (DBMA) ontology uses part-of in its hierarchy, so this would correspond to the following turtle: `<https://purl.brain-bican.org/ontology/dmbao/dmbao.owl> a owl:Ontology; OMO:0003014 rdfs:subClassOf, BFO:0000050`.
Relates an ontology to predicates/properties that should be used by user interfaces to render the hierarchical structure of the ontology. Typically, this is rdfs:subClassOf, but in ontologies that are partonomies, this might also include BFO:0000050 (part of). Tools like OLS can use predicates annotated with this property for rendering the ontology class hierarchy. There can be more than one hierarchical property. In the absence of any, it should be assumed that it is rdfs:subClassOf.
A serial number such as "12324X"; a stop sign; a written proper name such as "OBI
An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity.
An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.
tooth SubClassOf 'never in taxon' value 'Aves'
x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
Class: ?X DisjointWith: RO_0002162 some ?Y
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX never_in_taxon: <http://purl.obolibrary.org/obo/RO_0002161> CONSTRUCT { in_taxon: a owl:ObjectProperty . a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . ?x rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom [ a owl:Class ; owl:complementOf ?taxon ] ] . } WHERE { ?x never_in_taxon: ?taxon . }
A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B.
Class: <http://www.w3.org/2002/07/owl#Nothing> EquivalentTo: (BFO_0000050 some ?X) and (BFO_0000050 some ?Y)
PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX part_of: <http://purl.obolibrary.org/obo/BFO_0000050> PREFIX mutually_spatially_disjoint_with: <http://purl.obolibrary.org/obo/RO_0002171> CONSTRUCT { part_of: a owl:ObjectProperty . [ a owl:Restriction ; owl:onProperty part_of: ; owl:someValuesFrom ?x ; a owl:Restriction ; owl:onProperty part_of: ; owl:someValuesFrom ?y ] ] } WHERE { ?x mutually_spatially_disjoint_with: ?y . }
mutually spatially disjoint with
An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon.
taxonomic class assertion
S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
This relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take ongoing coordinated effort to resolve. Example: metencephalon in teleost
dubious for taxon
S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX present_in_taxon: <http://purl.obolibrary.org/obo/RO_0002175> CONSTRUCT { in_taxon: a owl:ObjectProperty . ?witness rdfs:label ?label . ?witness rdfs:subClassOf ?x . ?witness rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . } WHERE { ?x present_in_taxon: ?taxon . BIND(IRI(CONCAT( "http://purl.obolibrary.org/obo/RO_0002175#", MD5(STR(?x)), "-", MD5(STR(?taxon)) )) as ?witness) BIND(CONCAT(STR(?x), " in taxon ", STR(?taxon)) AS ?label) }
The SPARQL expansion for this relation introduces new named classes into the ontology. For this reason it is likely that the expansion should only be performed during a QC pipeline; the expanded output should usually not be included in a published version of the ontology.
present in taxon
An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL.
logical macro assertion
A logical macro assertion whose domain is an IRI for a class
The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL
logical macro assertion on a class
A logical macro assertion whose domain is an IRI for a property
logical macro assertion on a property
Used to annotate object properties to describe a logical meta-property or characteristic of the object property.
logical macro assertion on an object property
logical macro assertion on an annotation property
relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y
The general property hierarchy is: "directly P" SubPropertyOf "P" Transitive(P) Where we have an annotation assertion "directly P" "is direct form of" "P"
If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'
A shortcut relationship that holds between two entities based on their identity criteria
logical macro assertion involving identity
A shortcut relationship between two entities x and y1, such that the intent is that the relationship is functional and inverse function, but there is no guarantee that this property holds.
in approximate one to one relationship with
'anterior end of organism' is-opposite-of 'posterior end of organism'
'increase in temperature' is-opposite-of 'decrease in temperature'
x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x).
true if the two properties are disjoint, according to OWL semantics. This should only be used if using a logical axiom introduces a non-simple property violation.
nominally disjoint with
Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be "+", "-" or "0"
part-of is homeomorphic for independent continuants.
R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C.
R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C.
An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
This annotation property may be replaced with an annotation property from an external ontology such as IAO
A textual description of an axiom loss in this ontology compared to an external ontology.
Notes on the homology status of this class.
An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info.
Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
Notes on the how instances of this class vary across species.
Notes on the evolved function of instances of this class.
Notes on the structure, composition or histology of instances of this class.
Notes on the ontogenic development of instances of this class.
Notes on how similar or equivalent classes are represented in other ontologies.
Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy.
FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term
An alternative label for a class or property which has a more general meaning than the preferred name/primary label.
has broad synonym
disease characteristic (MONDO:0021125) has cross-reference (http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C41009"^^xsd:string
An annotation property that links an ontology entity or a statement to a prefixed identifier or URI.
An alternative label for a class or property which has the exact same meaning than the preferred name/primary label.
has exact synonym
An alternative label for a class or property which has a more specific meaning than the preferred name/primary label.
has narrow synonym
An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct.
has related synonym
is part of
my brain is part of my body (continuant parthood, two material entities)
my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
this day is part of this year (occurrent parthood)
a core relation that holds between a part and its whole
Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
part_of
part of
has part
my body has part my brain (continuant parthood, two material entities)
my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
this year has part this day (occurrent parthood)
a core relation that holds between a whole and its part
Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
has_part
realized in
this disease is realized in this disease course
this fragility is realized in this shattering
this investigator role is realized in this investigation
is realized by
realized_in
[copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process
realizes
this disease course realizes this disease
this investigation realizes this investigator role
this shattering realizes this fragility
Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process
to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
preceded by
x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
is preceded by
preceded_by
precedes
x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
occurs in
b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
occurs_in
unfolds in
unfolds_in
Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
site of
[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant
contains process
a 'derives from' object property between an entity (in CLO case, cell line) and a disease in a patient where the entity is derived from some cell in the patient who has the disease. This is a short cut relation that represents: 'derived from' some (cell and ('part of' some 'organism' and ('has disease' some disease)))
In most cases, the patient in the relation is used to refer human patient. However, an animal patient (or veterinary patient) can also be referred.
derives from patient having disease
A disease disposition has been realized by a bearer.
This is a shortcut relation. It is equivalent to: participates_in some 'disease couse' and realizes some disease
an object property that specifies a cell line repository for a specifc cell line.
is in cell line repository
an object property that represents a relation between a cell line cell and a disease.
is disease model for
HeLa ICRP cell is transfected to express a Initiator caspase reporter protein (IC-RP)
an object property that represents a relation between a cell line cell and a protein where the cell line cell is genetically transfected to stably express a foreign protein in the cell line cell.
transfected to express
a 'cell line cell derives from' object property between an entity (e.g., cell line cell in CLO) and an organism where the cell line cell is derived from some cell from the organism. In CLO, this is a short cut relation that represents: 'derived from' some (cell and ('part of' some organism))
derives from organism
a 'derives from' object property between an entity (i.e., cell line cell in CLO) and an anatomic part from an organism where the cell line cell is derived from some cell in the anatomic part (e.g., tissue or organ). The anatomic part is typically defined by UBERON in CLO. in CLO, this is a short cut relation that represents: 'derived from' some (cell and ('part of' some 'anatomic part'))
derives from anatomic part
derives from cell
derives from cell line cell
a 'derived from' object property that specifies the domain of the property is a cell line cell.
cell line cell derived from
a 'cell line cell derives from' object property between a cell line cell and an anatomic part from an organism where the cell line cell is derived from some cell in the tissue. The anatomic part is typically defined by UBERON in CLO. This is a short cut relation that represents: 'derived from' some (cell and ('part of' some 'anatomic part'))
cell line cell derived from anatomical part
a 'cell line cell derives from' object property between a cell line cell and an organism where the cell line cell is derived from some cell from the organism. This is a short cut relation that represents: 'derived from' some (cell and ('part of' some organism))
cell line cell derived from organism
induced by cell culture reagent
BIHi005-A-4 stem cell line cell is derived from BIHi005-A cell by knocking out the gene SORT1 from the BIHi005-A cell.
A 'derives from' object property that represents the relation between a cell line cell and a gene where the gene is not present in the cell line cell from a knockout process.
derives from cell with knockout gene
Stem cell line cell BIONi010-C-6 is derived from BIONi010-C where gene APOE has been modified from an isogenic modification.
A 'derives from' object property that represents the relation between a cell line cell and a gene where the gene is modified in the cell line cell via an isogenic modification process. An isogenic cell line is a cell line that has been engineered from a parental line through the introduction of a targeted gene mutation.
derives from cell with isogenic modification of gene
derives from cell with knockin gene
derives from cell with transgenic modification
executed by
intended to realize
has plan
intended plan process type
is about
see is_input_of example_of_usage
The inverse property of is specified input of
8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works.
PERSON: Alan Ruttenberg
has specified input
some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay
A relation between a completely executed planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
is specified input of
The inverse property of is specified output of
has specified output
is_manufactured_by
http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities)
c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this.
Liju Fan
has_make
has_manufacturer
A relation between a completely executed planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
is specified output of
A cell sorting process achieves the objective specification 'material separation objective'
This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process.
modified according to email thread from 1/23/09 in accordince with DT and PPPB branch
the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car.
Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form
PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349
This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process.
inheres in
this fragility is a characteristic of this vase
this red color is a characteristic of this apple
a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
inheres_in
Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
characteristic of
bearer of
this apple is bearer of this red color
this vase is bearer of this fragility
Inverse of characteristic_of
A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
bearer_of
is bearer of
has characteristic
participates in
this blood clot participates in this blood coagulation
this input material (or this output material) participates in this process
this investigator participates in this investigation
a relation between a continuant and a process, in which the continuant is somehow involved in the process
participates_in
has participant
this blood coagulation has participant this blood clot
this investigation has participant this investigator
this process has participant this input material (or this output material)
a relation between a process and a continuant, in which the continuant is somehow involved in the process
Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
has_participant
A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The journal article (a generically dependent continuant) is concretized as the quality (a specifically dependent continuant), and both depend on that copy of the printed journal (an independent continuant).
An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process).
A relationship between a generically dependent continuant and a specifically dependent continuant or process, in which the generically dependent continuant depends on some independent continuant or process in virtue of the fact that the specifically dependent continuant or process also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants or processes.
A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants.
is concretized as
A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant).
A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant.
A relationship between a specifically dependent continuant or process and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant or process also depends on that same independent continuant. Multiple specifically dependent continuants or processes can concretize the same generically dependent continuant.
concretizes
this catalysis function is a function of this enzyme
a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists.
function_of
is function of
This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
function of
this red color is a quality of this apple
a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
A quality inheres in its bearer at all times for which the quality exists.
is quality of
quality_of
quality of
this investigator role is a role of this person
a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.
is role of
role_of
role of
this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)
a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
has_function
has function
this apple has quality this red color
a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
has_quality
has quality
this person has role this investigator role (more colloquially: this person has this role of investigator)
a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
has_role
has role
a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence
has disposition
disposition of
this cell derives from this parent cell (cell division)
this nucleus derives from this parent nucleus (nuclear division)
a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'.
derives_from
derives from
this parent cell derives into this cell (cell division)
this parent nucleus derives into this nucleus (nuclear division)
a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'.
derives_into
derives into
is location of
my head is the location of my brain
this cage is the location of this rat
a relation between two independent continuants, the location and the target, in which the target is entirely within the location
Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
location_of
location of
located in
my brain is located in my head
this rat is located in this cage
a relation between two independent continuants, the target and the location, in which the target is entirely within the location
Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
located_in
This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation.
the surface of my skin is a 2D boundary of my body
a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity
A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts.
Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape.
2D_boundary_of
boundary of
is 2D boundary of
is boundary of
2D boundary of
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
has boundary
has_2D_boundary
has 2D boundary
Primitive instance level timing relation between events
before or simultaneous with
x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
simultaneous with
X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)
ends after
X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))
starts during
X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))
happens during
X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).
ends during
x overlaps y if and only if there exists some z such that x has part z and z part of y
http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
overlaps
A is spatially_disjoint_from B if and only if they have no parts in common
There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom.
Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy
'human p53 protein' SubClassOf some ('has prototype' some ('participates in' some 'DNA repair'))
heart SubClassOf 'has prototype' some ('participates in' some 'blood circulation')
x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a "canonical" heart, which participates in blood circulation.
Experimental. In future there may be a formalization in which this relation is treated as a shortcut to some modal logic axiom. We may decide to obsolete this and adopt a more specific evolutionary relationship (e.g. evolved from)
This property can be used to make weaker forms of certain relations by chaining an additional property. For example, we may say: retina SubClassOf has_prototype some 'detection of light'. i.e. every retina is related to a prototypical retina instance which is detecting some light. Note that this is very similar to 'capable of', but this relation affords a wider flexibility. E.g. we can make a relation between continuants.
has prototype
A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
capable of
x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
surrounded by
surrounds
Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.
temporally related to
p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
has input
p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.
has output
Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
In general you should not use this relation to make assertions - use one of the more specific relations below this one
This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from
developmentally preceded by
developmentally succeeded by
A mereological relationship or a topological relationship
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
mereotopologically related to
A relationship that holds between entities participating in some developmental process (GO:0032502)
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development
developmentally related to
enabled by
An organism that is a member of a population of organisms
is member of is a mereological relation between a item and a collection.
member of
has member is a mereological relation between a collection and an item.
has member
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
has developmental potential involving
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage.
relation between physical entity and a process or stage
x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y).
x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y).
x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).
holds between x and y if and only if the time point at which x starts is equivalent to the time point at which y ends. Formally: iff α(x) = ω(y).
DEPRECATED This relation is similar to but different in important respects to the characteristic-of relation. See comments on that relation for more information.
DEPRECATED inheres in
DEPRECATED bearer of
Do not use this relation directly. It is intended as a grouping for a set of relations regarding presentation of phenotypes and disease.
A relationship that holds between an organism and a disease. Here a disease is construed broadly as a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism.
This property only applies to anatomical entities.
Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison.
has quantity
Number of protons in an atomic nucleus
has atomic number
has number of atomic nuclei
has inchi string
An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
continuant
An entity that has temporal parts and that happens, unfolds or develops through time.
occurrent
b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
independent continuant
spatial region
p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
process
disposition
A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
realizable entity
quality
b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
specifically dependent continuant
A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
role
site
b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
generically dependent continuant
function
An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
Elucidation: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
material entity
immaterial entity
Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.
Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.
Nuclear particle of zero charge, spin 1/2 and rest mass of 1.008664904(14) u.
A nucleus is the positively charged central portion of an atom, excluding the orbital electrons.
Some people may be uncomfortable calling every proton an atomic nucleus
This is equivalent to CHEBI:33252
a maintaining cell culture process that keeps cell line cell alive and actively cultured.
A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture.
Yongqun He, Matthew Brush, Sirarat Sarntivijai, Alexander Diehl, Jie Zheng, Yu Lin, Bjoern Peters
A 'cell line cell' is a part of a cell line established through the passaging/selection of a primary cultured cells or the experimental modification of an existing cell line. New types of cell line cells are established after sufficient passaging of a primary culture to establish a stable and homogenous population that qualifies as a line (typically 1-20 passages), or following some spontaneous or experimental modification that confers novel characteristics to an existing line. A cell line cell typically has mutations of five or more genes compared to the original cell that derives the cell line cell. Some gene mutations may turn on some oncogenes. Cell line cells can be in active culture, stored in a quiescent state for future use (e.g. frozen in liquid nitrogen), or applied in experimental procedures.
suspension cell line culturing is a cell line culturing method where cells do not require a surface for growth and differentiation. This method is appropriate for cells that are adapted to suspension culture or cells that are non-adhesive (e.g. hematopoietic cells)
adherent cell line culturing is a cell line culturing method where cells require a surface for growth and differentiation.
a material processing that modifies an existing cell line cell to generate another cell line cell.
a role that inheres in a cell line repository organization.
an organization that serves as a repository of cell lines.
adherent on coated surface cell line culturing is an adherent cell line culturing method that the surface is coated with extracellular matrix component to increase adhesion properties and provide other signals needed for growth and differentiation.
adherent on coated surface cell line culturing
a cell line cell that is in the ATCC cell line repository
a cell line cell that is in the HyperCLDB cell line repository
an immortal human lymphocyte cell line cell that is derived from T cell.
immortal human T cell line cell
adherent on feeder cells cell line culturing
A cell line cell that is capable of replicating a limited number of times in culture before undergoing senescence.
Yongqun He, Matthew Brush, Sirarat Sarntivijai
A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line.
Yongqun He, Matthew Brush, Allen Xiang, Asiyah Yu Lin, Sirarat Sarntivijai, James Malone, Jie Zheng, Tomasz Adamusiak
An immortal cell line cell that derives from human.
immortal human cell line
An immortal skin-derived cell line cell that derives from cat.
An immortal skin-derived cell line cell that derives from frog.
immortal frog cell line cell
an immortal cell line cell that is generated by fusing two different types of cells. One of the parent cells is typically a cancer cell.
An immortal cell line cell that derives from zebra fish.
immortal zebra fish cell line cell
a cell line that requires suspension cell cuturing.
a cell line that is cultured through adherence cell culturing.
a cell culture growth mode that indicates a cell needs to adhere to a cell culture plate to grow.
a cell culture growth mode that indicates a cell can grow when the cell is suspended in cell culture medium.
a disposition that represents a mode of cell culture growth, i.e., the cell will grow at a specific cell culture mode. For example, an adherent cell culture growh mode means that the cell will grow when the cell is adhere to a cell culture plate.
He, Tong-Chuan, et al., Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512.: "To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene". Note that common usage in the literature is often of the form "a human colorectal cancer cell line", as seen above. But such references to studies in "a line" refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'.
A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).
In the spring of 2013, a working group comprised of domain experts and representatives from CLO, OBI, CL, and ReO worked to establish a consensus model and definitions of cultured cells across these efforts. This included a careful characterization of how the term 'cell line' should be defined and applied. Notes about this work and its outcomes can be found on the CLO wiki here: http://code.google.com/p/clo-ontology/wiki/Cell_Lines
The term 'line' is used when a culture has undergone an intentional experimental process to establish a more uniform and stable population of cells (see 'establishing cell line'). This will require one or more passages, but may involve additional selection processes. Through such passaging and/or selection processes, the resulting 'line' attains some level of genetic stability and compositional homogeneity which is typically absent in primary cultures. Because of their relative homogeneity, ‘lines’ are capable of being characterized and stably propagated over a period of time. A new *type* of cell line can be established not only through the passaging/selection of a primary culture, but also through experimental modifications of existing lines (e.g. immortalization, stable genetic modifications, drug selection for a resistant subset, etc.). The definition provided here establishes the 'scale' of cell populations that qualify as cell lines - specifically those with a shared propagation history in culture. In this way, the 'cell line' class demarcates populations that represent what researchers actually use in the practice of science - e.g. as inputs to culturing, experimentation, and sharing. The definition is such that cell lines will exhibit important attributes. For example, they will have a relatively homogenous cell type composition as they have experienced similar selective pressures due to their continuous co-propagation. In addition, these populations can also be characterized by a passage number, again owing to their common passaging history. As defined here, 'cell line' can refer to a population of cells in active culture, applied experimentally, or stored in a quiescent state for future use.
cell line
mixed adherent and suspension cell line culturing
clusters in suspension cell line culturing
Oliver Note: this term needs precise definition. will consult term users later.
Ba/F3 Stably co-expresses EpoR and JAK2V617F EpoR and JAK2V617F constructs
Ba/F3 cell line EpoR and JAK2V617F co-expression
CHO Established (in your ontology) Stably transfected with Cre-beta lactamase: Cre Bla CHO cell line
CHO cell line co-expression of lactamase
suspension with feeder cells cell line culturing
suspension-multicell aggregates cell line culturing
a immortal cell line that is dervied from mouse tissue.
immortal mouse cell line
a immortal cell line that is dervied from mouse macrophage.
immortal mouse macrophage cell line
a cell line that is derived from stem cell
a immortal cell line that is dervied from mouse liver.
immortal mouse liver cell line
a immortal cell line that is dervied from a Gorilla gorilla tissue.
immortal Gorilla gorilla cell line
a immortal stem cell line that is derived from somatic stem cell
a immortal somatic stem cell line that is derived from epithelial fate stem cell
immortal epithelial fate stem cell line cell
a immortal epithelial fate stem cell line that is derived from basal cell
a immortal somatic stem cell line that is derived from multi fate stem cell
a immortal multi fate stem cell line that is derived from neuronal stem cell
a immortal neuronal stem cell line that is derived from neuroblast
a immortal multi fate stem cell line that is derived from mesenchymal cell
a cell line that is derived from non-terminally differentiated cell
immortal non-terminally differentiated cell line
immortal non-terminally differentiated cell line cell
A connective tissue cell line that is derived from osteoblast.
a immortal non-terminally differentiated cell line that is derived from muscle precursor cell
immortal muscle precursor cell line cell
a immortal muscle precursor cell line that is derived from myoblast
a immortal myoblast cell line that is derived from fusion competent myoblast
immortal fusion competent myoblast cell line
immortal fusion competent myoblast cell line cell
a cell line that is derived from secretory cell
a immortal secretory cell line that is derived from glandular epithelial cell
immortal glandular epithelial cell line cell
a immortal glandular epithelial cell line cell that is derived from chromophil cell of anterior pituitary gland
immortal anterior pituitary gland chromophil cell line cell
a immortal chromophil cell line cell of anterior pituitary gland that is derived from thyrotroph
a immortal chromophil cell line of anterior pituitary gland that is derived from acidophil cell of pars distalis of adenohypophysis
immortal pars distalis of adenohypophysis acidophil cell line cell
An immortal glandular epithelial cell line that is derived from mucous neck cell
a immortal glandular epithelial cell line that is derived from glandular cell of stomach
immortal glandular cell line of stomach cell
a immortal glandular cell line of stomach that is derived from parietal cell
a immortal secretory cell line that is derived from exocrine cell
a immortal secretory cell line that is derived from endocrine cell
a immortal endocrine cell line that is derived from mast cell
a immortal endocrine cell line cell that is derived from neuroendocrine cell
a immortal endocrine cell line that is derived from Leydig cell
a immortal secretory cell line cell that is derived from Sertoli cell
a immortal secretory cell line that is derived from plasma cell
an immortal cell line cell that is derived from contractile cell
a immortal contractile cell line cell that is derived from myofibroblast cell
a immortal contractile cell line cell that is derived from muscle cell
a immortal muscle cell line cell that is derived from skeletal muscle cell
a immortal muscle cell line cell that is derived from smooth muscle cell
an immortal cell line cell that is derived from electrically active cell
immortal electrically active cell line cell
a immortal electrically active cell line cell that is derived from electrically responsive cell
immortal electrically responsive cell line cell
a immortal electrically responsive cell line cell that is derived from neuron
a immortal neuron cell line cell that is derived from bipolar neuron
a immortal bipolar neuron cell line cell that is derived from ON-bipolar cell
a immortal neuron cell line cell that is derived from peripheral neuron
immortal peripheral neuron cell line cell
a immortal neuron cell line cell that is derived from stellate cell
an immortal cell line cell that is derived from barrier cell
obsolete immortal barrier cell line cell
an immortal barrier cell line cell that is derived from lining cell
a immortal lining cell line cell that is derived from mesothelial cell
a immortal mesothelial cell line cell that is derived from seminiferous tubule epithelial cell
immortal seminiferous tubule epithelial cell line cell
a immortal seminiferous tubule epithelial cell line cell that is derived from spermatocyte
a immortal lining cell line cell that is derived from endothelial cell
a immortal barrier cell line cell that is derived from myelinating Schwann cell
immortal myelinating Schwann cell line cell
a cell line that is derived from motile cell
a immortal motile cell line that is derived from phagocyte
a immortal phagocyte cell line that is derived from mononuclear phagocyte
immortal mononuclear phagocyte cell line cell
a immortal phagocyte cell line that is derived from macrophage
a immortal macrophage cell line that is derived from tissue-resident macrophage
immortal tissue-resident macrophage cell line cell
a immortal tissue-resident macrophage cell line that is derived from microglial cell
a immortal tissue-resident macrophage cell line that is derived from peritoneal macrophage
immortal peritoneal macrophage cell line cell
An immortal phagocyte cell line that is derived from prohemocyte (sensu Nematoda and Protostomia).
immortal prohemocyte (sensu Nematoda and Protostomia) cell line cell
a immortal motile cell line that is derived from amoeboid cell
a immortal motile cell line that is derived from leukocyte
a immortal leukocyte cell line that is derived from dendritic cell
a immortal dendritic cell line that is derived from Langerhans cell
a immortal leukocyte cell line that is derived from myeloid leukocyte
immortal myeloid leukocyte cell line cell
a immortal myeloid leukocyte cell line that is derived from monocyte
a immortal leukocyte cell line that is derived from nongranular leukocyte
immortal nongranular leukocyte cell line
immortal nongranular leukocyte cell line cell
a immortal nongranular leukocyte cell line that is derived from lymphocyte
a immortal lymphocyte cell line that is derived from T cell
a immortal T cell line that is derived from alpha-beta T cell
a immortal alpha-beta T cell line that is derived from immature alpha-beta T cell
immortal immature alpha-beta T cell line
immortal immature alpha-beta T cell line cell
a immortal immature alpha-beta T cell line that is derived from double-positive, alpha-beta thymocyte
immortal double-positive, alpha-beta thymocyte cell line
immortal double-positive, alpha-beta thymocyte cell line cell
a immortal alpha-beta T cell line that is derived from mature alpha-beta T cell
immortal mature alpha-beta T cell line cell
a immortal mature alpha-beta T cell line that is derived from CD4-positive, CD25-positive, alpha-beta regulatory T cell
immortal CD4-positive, CD25-positive, alpha-beta regulatory T cell line
immortal CD4-positive, CD25-positive, alpha-beta regulatory T cell line cell
a immortal CD4-positive, CD25-positive, alpha-beta regulatory T cell line that is derived from induced T-regulatory cell
immortal induced T-regulatory cell line cell
a immortal T cell line that is derived from mature T cell
a immortal mature T cell line that is derived from helper T cell
a immortal T cell line that is derived from immature T cell
a immortal lymphocyte cell line that is derived from B cell
immortal B-cell line cell
a immortal B cell line that is derived from precursor B cell
a immortal lymphocyte cell line that is derived from natural killer cell
a cell line that is derived from single nucleate cell
a cell line that is derived from multinucleate cell
An immortal cell line cell that is derived from eukaryotic cell.
a immortal eukaryotic cell line that is derived from vegetative cell (sensu Mycetozoa)
immortal vegetative cell line (sensu Mycetozoa)
immortal vegetative cell line (sensu Mycetozoa) cell
a immortal vegetative cell line (sensu Mycetozoa) that is derived from aggregate cell
a immortal vegetative cell line (sensu Mycetozoa) that is derived from anterior like cell
a immortal eukaryotic cell line that is derived from animal cell
'animal cell' is deprecated from CL and merged to 'cell'.
a immortal animal cell line that is derived from epithelial cell
a immortal epithelial cell line that is derived from duct epithelial cell
a immortal epithelial cell line that is derived from columnar/cuboidal epithelial cell
immortal columnar/cuboidal epithelial cell line cell
a immortal columnar/cuboidal epithelial cell line that is derived from neurecto-epithelial cell
immortal neurecto-epithelial cell line cell
a immortal neurecto-epithelial cell line that is derived from melanocyte
a immortal neurecto-epithelial cell line that is derived from pigmented epithelial cell
immortal pigmented epithelial cell line cell
a immortal epithelial cell line that is derived from squamous epithelial cell
immortal squamous epithelial cell line cell
a immortal squamous epithelial cell line that is derived from stratified squamous epithelial cell
immortal stratified squamous epithelial cell line cell
a immortal stratified squamous epithelial cell line that is derived from keratinizing barrier epithelial cell
immortal keratinizing barrier epithelial cell line cell
a immortal keratinizing barrier epithelial cell line that is derived from keratinocyte
a immortal squamous epithelial cell line that is derived from epidermal cell
a immortal epithelial cell line that is derived from stratified epithelial cell
immortal stratified epithelial cell line cell
a immortal epithelial cell line that is derived from epithelial cell of lung
immortal epithelial cell line of lung cell
a immortal epithelial cell line that is derived from epithelial cell of pancreas
immortal epithelial cell line of pancreas cell
a immortal epithelial cell line that is derived from ecto-epithelial cell
a immortal epithelial cell line that is derived from meso-epithelial cell
a immortal animal cell line that is derived from extraembryonic cell
a immortal extraembryonic cell line that is derived from trophoblast cell
a immortal animal cell line that is derived from hematopoietic cell
a immortal hematopoietic cell line that is derived from megakaryocyte-erythroid progenitor cell
immortal megakaryocyte-erythroid progenitor cell line
immortal megakaryocyte-erythroid progenitor cell line cell
a immortal hematopoietic cell line that is derived from blood cell
a immortal hematopoietic cell line that is derived from myeloid cell
a immortal myeloid cell line that is derived from erythroblast
a immortal hematopoietic cell line that is derived from hematopoietic lineage restricted progenitor cell
immortal hematopoietic lineage restricted progenitor cell line
immortal hematopoietic lineage restricted progenitor cell line cell
a immortal hematopoietic lineage restricted progenitor cell line that is derived from pro-B cell
a immortal hematopoietic lineage restricted progenitor cell line that is derived from myeloblast
a immortal myeloblast cell line that is derived from basophilic myeloblast
immortal basophilic myeloblast cell line
immortal basophilic myeloblast cell line cell
a immortal animal cell line that is derived from neural cell
a immortal neural cell line that is derived from glial cell
a immortal glial cell line that is derived from glial cell (sensu Vertebrata)
immortal glial cell line (sensu Vertebrata)
immortal glial cell line (sensu Vertebrata) cell
a immortal glial cell line (sensu Vertebrata) that is derived from astrocyte
a immortal animal cell line that is derived from connective tissue cell
immortal connective tissue cell line cell
a immortal connective tissue cell line that is derived from fibroblast
a immortal connective tissue cell line that is derived from stromal cell
a cell line that is derived from stuff accumulating cell
immortal stuff accumulating cell line cell
a cell line that is derived from parenchymal cell
a cell line that is derived from nucleate cell
a cell line that is derived from somatic cell
obsolete immortal somatic cell line cell
a immortal epithelial cell line cell that is derived from HeLa cell
an immortal cell line cell that is established by fusing a specific antibody-producing B cell with a myeloma (B cell cancer) cell that is selected for its ability to produce a monoclonal antibody.
The production of monoclonal antibodies using the hybridoma technology was invented by Cesar Milstein and Georges J. F. Köhler in 1975. They shared the Nobel Prize of 1984 for Medicine and Physiology with Niels Kaj Jerne, who made other contributions to immunology.
WEB: http://en.wikipedia.org/wiki/Hybridoma_technology
a function of a cell that can be passaged in culture medium without death or genetic change.
cell line lineage is a history of the development of a cell line. The cell line lineage may include the original cell type from a tissue and organism that derives the cell line cell. It may also include the cell line passage and cell culturing information.
This term will be a subclass of BFO 2 'history'. The BFO 2 'history' term will be imported to CLO after the BFO 2 is finalized.
cell line lineage
a cell line cell that is in the Coriell cell line repositories.
Coriell cell line cell
a cell line cell that is in the RIKEN Cell bank
RIKEN Cell Bank cell
A cell line comprised of cells which can all be traced back to a single ancestor cell, and which therefore can be treated as identical. This can be used to study just the progeny of single cells.
MHB 2013-07-16: This should be made into a defined class, using an axiom referencing a clonal cell expansion process, or a clonal cell line creation process.
cloned cell line
An immortal B cell line cell that derives from peripheral vein.
immortal peripheral vein-derived B cell line cell
An immortal cell line cell that derives from organism part.
immortal organism part-derived cell line cell
An immortal fibroblast cell line cell that derives from arm.
immortal arm-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from organism part.
immortal organism part-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from tunica albuginea of testis.
immortal tunica albuginea of testis-derived fibroblast cell line cell
An immortal cell line cell that derives from amniotic fluid.
immortal amniotic fluid-derived cell line cell
An immortal T cell line cell that derives from peripheral vein.
immortal peripheral vein-derived T cell line cell
An immortal fibroblast cell line cell that derives from animal ovary.
immortal animal ovary-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from skin.
immortal skin-derived fibroblast cell line cell
An immortal keratinocyte cell line cell that derives from organism part.
immortal organism part-derived keratinocyte cell line cell
An immortal fibroblast cell line cell that derives from testis.
immortal testis-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from liver.
immortal liver-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from lung.
immortal lung-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from embryo.
immortal embryo-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from thoracic aorta.
immortal thoracic aorta-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from gum.
immortal gum-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from digit.
immortal digit-derived fibroblast cell line cell
An immortal cell line cell that derives from skin.
An immortal smooth muscle cell line cell that derives from trachealis.
immortal trachealis-derived smooth muscle cell line cell
An immortal fibroblast cell line cell that derives from neck.
immortal neck-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from umbilical cord.
immortal umbilical cord-derived fibroblast cell line cell
An immortal endothelial cell line cell that derives from abdominal aorta.
immortal abdominal aorta-derived endothelial cell line cell
An immortal endothelial cell line cell that derives from iliac vein.
immortal iliac vein-derived endothelial cell line cell
An immortal endothelial cell line cell that derives from common iliac artery.
immortal common iliac artery-derived endothelial cell line cell
An immortal fibroblast cell line cell that derives from gonad.
immortal gonad-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from amnion.
immortal amnion-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from thigh.
immortal thigh-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from umbilical vein.
immortal umbilical vein-derived fibroblast cell line cell
An immortal cell line cell that derives from vasculature.
immortal vasculature-derived cell line cell
An immortal cell line cell that derives from spleen.
An immortal cell line cell that derives from multi-cellular organism.
immortal multi-cellular organism-derived cell line cell
An immortal cell line cell that derives from fetal membrane.
immortal fetal membrane-derived cell line cell
An immortal cell line cell that derives from dento-alveolar joint.
immortal dento-alveolar joint-derived cell line cell
An immortal cell line cell that derives from mixed endoderm/mesoderm-derived structure.
immortal mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal cell line cell that derives from late embryo.
immortal late embryo-derived cell line cell
An immortal cell line cell that derives from muscle spindle.
immortal muscle spindle-derived cell line cell
An immortal cell line cell that derives from thymus.
An immortal cell line cell that derives from amnion.
An immortal cell line cell that derives from tongue.
An immortal cell line cell that derives from pair of lungs.
An immortal cell line cell that derives from kidney.
An immortal fibroblast cell line cell that derives from abdominal cavity.
immortal abdominal cavity-derived fibroblast cell line cell
An immortal smooth muscle cell line cell that derives from thoracic aorta.
immortal thoracic aorta-derived smooth muscle cell line cell
An immortal cell line cell that derives from placenta.
immortal placenta-derived cell line cell
An immortal fibroblast cell line cell that derives from pericardium.
immortal pericardium-derived fibroblast cell line cell
An immortal cell line cell that derives from embryo.
An immortal fibroblast cell line cell that derives from foetal structure.
immortal foetal structure-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from external genitalia.
immortal external genitalia-derived fibroblast cell line cell
An immortal cell line cell that derives from prostate gland.
immortal prostate gland-derived cell line cell
An immortal cell line cell that derives from septum of telencephalon.
immortal septum of telencephalon-derived cell line cell
An immortal cell line cell that derives from larva.
An immortal cell line cell that derives from area X.
An immortal cell line cell that derives from somatic nervous system.
immortal somatic nervous system-derived cell line cell
An immortal cell line cell that derives from lymph.
An immortal endothelial cell line cell that derives from thoracic aorta.
immortal thoracic aorta-derived endothelial cell line cell
An immortal cell line cell that derives from liver.
An immortal cell line cell that derives from colon.
An immortal cell line cell that derives from caecum.
An immortal cell line cell that derives from pancreas.
immortal pancreas-derived cell line cell
An immortal cell line cell that derives from brain.
An immortal cell line cell that derives from tail.
An immortal cell line cell that derives from collecting duct of renal tubule.
immortal collecting duct of renal tubule-derived cell line cell
An immortal cell line cell that derives from mesonephros.
immortal mesonephros-derived cell line cell
An immortal cell line cell that derives from female gonad.
immortal female gonad-derived cell line cell
An immortal cell line cell that derives from chorion.
An immortal cell line cell that derives from lymphoid follicle.
immortal lymphoid follicle-derived cell line cell
An immortal fibroblast cell line cell that derives from leg.
immortal leg-derived fibroblast cell line cell
An immortal cell line cell that derives from limb/fin.
immortal limb/fin-derived cell line cell
An immortal cell line cell that derives from testis.
An immortal cell line cell that derives from stomach.
An immortal cell line cell that derives from endothelium.
immortal endothelium-derived cell line cell
An immortal fibroblast cell line cell that derives from foreskin.
immortal foreskin-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from achilles tendon.
immortal achilles tendon-derived fibroblast cell line cell
An immortal cell line cell that derives from bone element.
immortal bone element-derived cell line cell
An immortal cell line cell that derives from thyroid gland.
immortal thyroid gland-derived cell line cell
An immortal cell line cell that derives from urinary bladder.
immortal urinary bladder-derived cell line cell
An immortal cell line cell that derives from acetabular part of hip bone.
immortal acetabular part of hip bone-derived cell line cell
An immortal cell line cell that derives from breast.
An immortal cell line cell that derives from epithelium.
immortal epithelium-derived cell line cell
An immortal cell line cell that derives from comma-shaped body.
immortal comma-shaped body-derived cell line cell
An immortal cell line cell that derives from supra-orbital vein.
immortal supra-orbital vein-derived cell line cell
An immortal fibroblast cell line cell that derives from ear.
immortal ear-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from inguinal region.
immortal inguinal region-derived fibroblast cell line cell
An immortal cell line cell that derives from mesothelium.
immortal mesothelium-derived cell line cell
An immortal cell line cell that derives from uterus.
An immortal cell line cell that derives from endometrium.
immortal endometrium-derived cell line cell
An immortal cell line cell that derives from uterine cervix.
immortal uterine cervix-derived cell line cell
An immortal cell line cell that derives from heart.
An immortal cell line cell that derives from pituitary gland.
immortal pituitary gland-derived cell line cell
An immortal cell line cell that derives from gill.
An immortal cell line cell that derives from follicular fluid.
immortal follicular fluid-derived cell line cell
An immortal cell line cell that derives from eye.
An immortal plasma cell line cell that derives from organism part.
immortal organism part-derived plasma cell line cell
An immortal cell line cell that derives from floating rib.
immortal floating rib-derived cell line cell
An immortal cell line cell that derives from mammary gland.
immortal mammary gland-derived cell line cell
An immortal fibroblast cell line cell that derives from thorax.
immortal thorax-derived fibroblast cell line cell
An immortal cell line cell that derives from paired fin.
immortal paired fin-derived cell line cell
An immortal cell line cell that derives from neural nucleus.
immortal neural nucleus-derived cell line cell
An immortal cell line cell that derives from Ammon's horn.
immortal Ammon's horn-derived cell line cell
An immortal cell line cell that derives from bone marrow.
immortal bone marrow-derived cell line cell
An immortal cell line cell that derives from islet of Langerhans.
immortal islet of Langerhans-derived cell line cell
An immortal cell line cell that derives from pyramid of medulla oblongata.
immortal pyramid of medulla oblongata-derived cell line cell
a hybridoma cell line cell that is established by fusing cells from two mice.
most hybridoma cell line cells are mouse x mouse
mouse x mouse hybridoma cell line cell
An immortal epithelial cell line cell that derives from uterine cervix.
immortal uterine cervix-derived epithelial cell line cell
An immortal cell line cell that derives from ileocecal junction.
immortal ileocecal junction-derived cell line cell
An immortal cell line cell that derives from compact bone.
immortal compact bone-derived cell line cell
An immortal cell line cell that derives from abdominal aorta.
immortal abdominal aorta-derived cell line cell
An immortal cell line cell that derives from bronchus.
immortal bronchus-derived cell line cell
An immortal cell line cell that derives from iliac artery.
immortal iliac artery-derived cell line cell
An immortal cell line cell that derives from synovial membrane of synovial joint.
immortal synovial membrane of synovial joint-derived cell line cell
An immortal cell line cell that derives from iliac vein.
immortal iliac vein-derived cell line cell
An immortal cell line cell that derives from vagina.
An immortal cell line cell that derives from larynx.
An immortal cell line cell that derives from inferior cervical ganglion.
immortal inferior cervical ganglion-derived cell line cell
An immortal cell line cell that derives from esophagus.
immortal esophagus-derived cell line cell
An immortal cell line cell that derives from femoral artery.
immortal femoral artery-derived cell line cell
An immortal cell line cell that derives from prepuce of penis.
immortal prepuce of penis-derived cell line cell
An immortal cell line cell that derives from gingival epithelium.
immortal gingival epithelium-derived cell line cell
An immortal cell line cell that derives from gingiva.
An immortal cell line cell that derives from mouth.
An immortal cell line cell that derives from peripheral vein.
immortal peripheral vein-derived cell line cell
An immortal cell line cell that derives from peritoneum.
immortal peritoneum-derived cell line cell
An immortal cell line cell that derives from round window.
immortal round window-derived cell line cell
An immortal fibroblast cell line cell that derives from conjunctiva structure.
immortal conjunctiva structure-derived fibroblast cell line cell
An immortal cell line cell that derives from intestine.
immortal intestine-derived cell line cell
An immortal cell line cell that derives from rectum.
An immortal cell line cell that derives from pulmonary vein.
immortal pulmonary vein-derived cell line cell
An immortal fibroblast cell line cell that derives from buttock.
immortal buttock-derived fibroblast cell line cell
An immortal cell line cell that derives from tonsil.
An immortal fibroblast cell line cell that derives from umbilicus.
immortal umbilicus-derived fibroblast cell line cell
An immortal cell line cell that derives from posterior commissure.
immortal posterior commissure-derived cell line cell
An immortal cell line cell that derives from soft palate.
immortal soft palate-derived cell line cell
An immortal cell line cell that derives from adrenal gland.
immortal adrenal gland-derived cell line cell
An immortal cell line cell that derives from pronephros.
immortal pronephros-derived cell line cell
An immortal smooth muscle cell line cell that derives from organism part.
immortal organism part-derived smooth muscle cell line cell
An immortal cell line cell that derives from sublingual artery.
immortal sublingual artery-derived cell line cell
An immortal cell line cell that derives from aorta.
An immortal cell line cell that derives from ligament.
immortal ligament-derived cell line cell
An immortal fibroblast cell line cell that derives from uterus.
immortal uterus-derived fibroblast cell line cell
An immortal cell line cell that derives from cerebral lobe.
immortal cerebral lobe-derived cell line cell
An immortal cell line cell that derives from squamous part of temporal bone.
immortal squamous part of temporal bone-derived cell line cell
An immortal fibroblast cell line cell that derives from pronephros.
immortal pronephros-derived fibroblast cell line cell
An immortal cell line cell that derives from mucosa.
An immortal cell line cell that derives from epidermis.
immortal epidermis-derived cell line cell
An immortal cell line cell that derives from submandibular gland.
immortal submandibular gland-derived cell line cell
An immortal mesothelial cell line cell that derives from lung.
immortal lung-derived mesothelial cell line cell
An immortal epithelial cell line cell that derives from eye structure.
immortal eye structure-derived epithelial cell line cell
An immortal fibroblast cell line cell that derives from hip.
immortal hip-derived fibroblast cell line cell
An immortal cell line cell that derives from prostate epithelium.
immortal prostate epithelium-derived cell line cell
An immortal cell line cell that derives from retinal neural layer.
immortal retinal neural layer-derived cell line cell
An immortal cell line cell that derives from ureter.
An immortal smooth muscle cell line cell that derives from iliac vein.
immortal iliac vein-derived smooth muscle cell line cell
An immortal smooth muscle cell line cell that derives from common iliac artery.
immortal common iliac artery-derived smooth muscle cell line cell
An immortal keratinocyte cell line cell that derives from mammary gland.
immortal mammary gland-derived keratinocyte cell line cell
An immortal endothelial cell line cell that derives from umbilical vein.
immortal umbilical vein-derived endothelial cell line cell
An immortal fibroblast cell line cell that derives from scalp.
immortal scalp-derived fibroblast cell line cell
An immortal myoblast cell line cell that derives from skeletal muscle.
immortal skeletal muscle-derived myoblast cell line cell
An immortal endothelial cell line cell that derives from organism part.
immortal organism part-derived endothelial cell line cell
An immortal fibroblast cell line cell that derives from sacrum.
immortal sacrum-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from shoulder.
immortal shoulder-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from placenta.
immortal placenta-derived fibroblast cell line cell
An immortal cell line cell that derives from dermis.
An immortal cell line cell that derives from cornea.
An immortal cell line cell that derives from mammalian vulva.
immortal mammalian vulva-derived cell line cell
An immortal cell line cell that derives from spherical lensed eye.
immortal spherical lensed eye-derived cell line cell
An immortal cell line cell that derives from ileum.
An immortal fibroblast cell line cell that derives from cervix.
immortal cervix-derived fibroblast cell line cell
An immortal myoblast cell line cell that derives from rhomboid.
immortal rhomboid-derived myoblast cell line cell
An immortal cell line cell that derives from abdominal cavity.
immortal abdominal cavity-derived cell line cell
An immortal cell line cell that derives from umbilical vein.
immortal umbilical vein-derived cell line cell
An immortal cell line cell that derives from duodenum.
immortal duodenum-derived cell line cell
An immortal cell line cell that derives from connective tissue.
immortal connective tissue-derived cell line cell
An immortal cell line cell that derives from parotid gland.
immortal parotid gland-derived cell line cell
An immortal fibroblast cell line cell that derives from ischium.
immortal ischium-derived fibroblast cell line cell
An immortal cell line cell that derives from buttock.
An immortal cell line cell that derives from anatomical cluster.
immortal anatomical cluster-derived cell line cell
An immortal cell line cell that derives from thigh.
An immortal cell line cell that derives from chordate pharynx.
immortal chordate pharynx-derived cell line cell
An immortal cell line cell that derives from retina.
An immortal cell line cell that derives from yolk sac.
immortal yolk sac-derived cell line cell
An immortal cell line cell that derives from nasal concha.
immortal nasal concha-derived cell line cell
An immortal cell line cell that derives from arm.
An immortal cell line cell that derives from sacrum.
An immortal cell line cell that derives from conjunctiva.
immortal conjunctiva-derived cell line cell
An immortal cell line cell that derives from trachea.
An immortal cell line cell that derives from respiration organ.
immortal respiration organ-derived cell line cell
An immortal cell line cell that derives from renal glomerulus.
immortal renal glomerulus-derived cell line cell
An immortal cell line cell that derives from nephron tubule.
immortal nephron tubule-derived cell line cell
An immortal cell line cell that derives from sternum.
An immortal cell line cell that derives from hypodermis.
immortal hypodermis-derived cell line cell
An immortal cell line cell that derives from proximal tubule.
immortal proximal tubule-derived cell line cell
An immortal cell line cell that derives from mucosa of vagina.
immortal mucosa of vagina-derived cell line cell
An immortal cell line cell that derives from endocervix.
immortal endocervix-derived cell line cell
An immortal mesothelial cell line cell that derives from organism part.
immortal organism part-derived mesothelial cell line cell
An immortal peripheral vein-derived B cell line cell that derives from human.
immortal human peripheral vein-derived B cell line cell
An immortal cell line cell that derives from pulmonary nerve plexus.
immortal pulmonary nerve plexus-derived cell line cell
An immortal cell line cell that derives from pelvic fin.
immortal pelvic fin-derived cell line cell
An immortal cell line cell that derives from right ureter.
immortal right ureter-derived cell line cell
An immortal cell line cell that derives from superior rostral sulcus.
immortal superior rostral sulcus-derived cell line cell
An immortal cell line cell that derives from gonad.
An immortal fibroblast cell line cell that derives from cornea structure.
immortal cornea structure-derived fibroblast cell line cell
An immortal cell line cell that derives from glomerular capsule.
immortal glomerular capsule-derived cell line cell
An immortal cell line cell that derives from nasal vestibule.
immortal nasal vestibule-derived cell line cell
An immortal cell line cell that derives from adrenal cortex.
immortal adrenal cortex-derived cell line cell
An immortal fibroblast cell line cell that derives from 16914.
immortal 16914-derived fibroblast cell line cell
An immortal epithelial cell line cell that derives from organism part.
immortal organism part-derived epithelial cell line cell
An immortal fibroblast cell line cell that derives from axilla.
immortal axilla-derived fibroblast cell line cell
An immortal endothelial cell line cell that derives from pulmonary artery.
immortal pulmonary artery-derived endothelial cell line cell
An immortal smooth muscle cell line cell that derives from pulmonary artery.
immortal pulmonary artery-derived smooth muscle cell line cell
An immortal epithelial cell line cell that derives from retina structure.
immortal retina structure-derived epithelial cell line cell
An immortal fibroblast cell line cell that derives from calf.
immortal calf-derived fibroblast cell line cell
An immortal fibroblast cell line cell that derives from nose structure.
immortal nose structure-derived fibroblast cell line cell
An immortal smooth muscle cell line cell that derives from carotid artery.
immortal carotid artery-derived smooth muscle cell line cell
An immortal fibroblast cell line cell that derives from brain.
immortal brain-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from chimpanzee.
immortal chimpanzee peripheral vein-derived B cell line cell
An immortal arm-derived fibroblast cell line cell that derives from human.
immortal human arm-derived fibroblast cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from human.
immortal human organism part-derived fibroblast cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from cattle.
immortal cattle organism part-derived fibroblast cell line cell
An immortal tunica albuginea of testis-derived fibroblast cell line cell that derives from human.
immortal human tunica albuginea of testis-derived fibroblast cell line cell
An immortal amniotic fluid-derived cell line cell that derives from human.
immortal human amniotic fluid-derived cell line cell
An immortal peripheral vein-derived T cell line cell that derives from human.
immortal human peripheral vein-derived T cell line cell
An immortal organism part-derived cell line cell that derives from rat.
immortal rat organism part-derived cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from chimpanzee.
immortal chimpanzee organism part-derived fibroblast cell line cell
An immortal animal ovary-derived fibroblast cell line cell that derives from Chinese hamster.
immortal Chinese hamster ovary-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Bornean orangutan.
immortal Bornean orangutan skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from pig-tailed macaque.
immortal pig-tailed macaque skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Kenya baboon.
immortal Kenya baboon skin-derived fibroblast cell line cell
An immortal organism part-derived cell line cell that derives from long-tailed macaque.
immortal long-tailed macaque organism part-derived cell line cell
An immortal organism part-derived keratinocyte cell line cell that derives from pig-tailed macaque.
immortal pig-tailed macaque organism part-derived keratinocyte cell line cell
An immortal organism part-derived keratinocyte cell line cell that derives from long-tailed macaque.
immortal long-tailed macaque organism part-derived keratinocyte cell line cell
An immortal testis-derived fibroblast cell line cell that derives from human.
immortal human testis-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from pygmy chimpanzee.
immortal pygmy chimpanzee skin-derived fibroblast cell line cell
An immortal liver-derived fibroblast cell line cell that derives from human.
immortal human liver-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from red-bellied lemur.
immortal red-bellied lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from black lemur.
immortal black lemur skin-derived fibroblast cell line cell
An immortal organism part-derived keratinocyte cell line cell that derives from Kenya baboon.
immortal Kenya baboon organism part-derived keratinocyte cell line cell
An immortal skin-derived fibroblast cell line cell that derives from variegated lemur.
immortal variegated lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from small-eared galago.
immortal small-eared galago skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from western gorilla.
immortal western gorilla skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Angolan colobus.
immortal Angolan colobus skin-derived fibroblast cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from mouse.
immortal mouse organism part-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Colobus guereza.
immortal Colobus guereza skin-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from pygmy chimpanzee.
immortal pygmy chimpanzee peripheral vein-derived B cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Allen's swamp monkey.
immortal Allen's swamp monkey skin-derived fibroblast cell line cell
An immortal lung-derived fibroblast cell line cell that derives from human.
immortal human lung-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from mongoose lemur.
immortal mongoose lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Ring-tailed lemur.
immortal Ring-tailed lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from chimpanzee.
immortal chimpanzee skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from rhesus macaque.
immortal rhesus macaque skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from black-handed spider monkey.
immortal black-handed spider monkey skin-derived fibroblast cell line cell
An immortal embryo-derived fibroblast cell line cell that derives from Chinese hamster.
immortal Chinese hamster embryo-derived fibroblast cell line cell
An immortal thoracic aorta-derived fibroblast cell line cell that derives from rat.
immortal rat thoracic aorta-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Charles Island giant tortoise.
immortal Charles Island giant tortoise skin-derived fibroblast cell line cell
An immortal testis-derived fibroblast cell line cell that derives from rat.
immortal rat testis-derived fibroblast cell line cell
An immortal gum-derived fibroblast cell line cell that derives from human.
immortal human gum-derived fibroblast cell line cell
An immortal organism part-derived cell line cell that derives from mouse.
immortal mouse organism part-derived cell line cell
An immortal digit-derived fibroblast cell line cell that derives from human.
immortal human digit-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from human.
immortal human skin-derived fibroblast cell line cell
An immortal skin-derived cell line cell that derives from human.
immortal human skin-derived cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from Indian muntjac.
immortal Indian muntjac organism part-derived fibroblast cell line cell
An immortal organism part-derived cell line cell that derives from human.
immortal human organism part-derived cell line cell
An immortal trachealis-derived smooth muscle cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit trachealis-derived smooth muscle cell line cell
An immortal neck-derived fibroblast cell line cell that derives from human.
immortal human neck-derived fibroblast cell line cell
An immortal umbilical cord-derived fibroblast cell line cell that derives from human.
immortal human umbilical cord-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from lesser panda.
immortal lesser panda skin-derived fibroblast cell line cell
An immortal abdominal aorta-derived endothelial cell line cell that derives from human.
immortal human abdominal aorta-derived endothelial cell line cell
An immortal iliac vein-derived endothelial cell line cell that derives from human.
immortal human iliac vein-derived endothelial cell line cell
An immortal common iliac artery-derived endothelial cell line cell that derives from human.
immortal human common iliac artery-derived endothelial cell line cell
An immortal embryo-derived fibroblast cell line cell that derives from human.
immortal human embryo-derived fibroblast cell line cell
An immortal gonad-derived fibroblast cell line cell that derives from human.
immortal human gonad-derived fibroblast cell line cell
An immortal amnion-derived fibroblast cell line cell that derives from human.
immortal human amnion-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from human.
immortal human thigh-derived fibroblast cell line cell
An immortal umbilical vein-derived fibroblast cell line cell that derives from human.
immortal human umbilical vein-derived fibroblast cell line cell
An immortal cell line cell that derives from cattle.
An immortal vasculature-derived cell line cell that derives from cattle.
immortal cattle vasculature-derived cell line cell
An immortal spleen-derived cell line cell that derives from cat.
immortal cat spleen-derived cell line cell
An immortal fibroblast cell line cell that derives from cat.
An immortal cell line cell that derives from cat.
An immortal multi-cellular organism-derived cell line cell that derives from cat.
immortal cat multi-cellular organism-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from cattle.
immortal cattle fetal membrane-derived cell line cell
An immortal spleen-derived cell line cell that derives from cattle.
immortal cattle spleen-derived cell line cell
An immortal dento-alveolar joint-derived cell line cell that derives from cattle.
immortal cattle dento-alveolar joint-derived cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from cattle.
immortal cattle mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal late embryo-derived cell line cell that derives from cat.
immortal cat late embryo-derived cell line cell
An immortal muscle spindle-derived cell line cell that derives from cat.
immortal cat muscle spindle-derived cell line cell
An immortal thymus-derived cell line cell that derives from cat.
immortal cat thymus-derived cell line cell
An immortal amnion-derived cell line cell that derives from human.
immortal human amnion-derived cell line cell
immortal cat skin-derived cell line cell
An immortal lymphocyte cell line cell that derives from human.
immortal human lymphocyte cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from cat.
immortal cat mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal tongue-derived cell line cell that derives from cat.
immortal cat tongue-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from cat.
immortal cat pair of lungs-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from cat.
immortal cat fetal membrane-derived cell line cell
An immortal kidney-derived cell line cell that derives from cat.
immortal cat kidney-derived cell line cell
An immortal lung-derived fibroblast cell line cell that derives from dog.
immortal dog lung-derived fibroblast cell line cell
An immortal abdominal cavity-derived fibroblast cell line cell that derives from dog.
immortal dog abdominal cavity-derived fibroblast cell line cell
An immortal thoracic aorta-derived smooth muscle cell line cell that derives from dog.
immortal dog thoracic aorta-derived smooth muscle cell line cell
An immortal placenta-derived cell line cell that derives from cat.
immortal cat placenta-derived cell line cell
An immortal skin-derived cell line cell that derives from rat.
immortal rat skin-derived cell line cell
An immortal fibroblast cell line cell that derives from human.
immortal human fibroblast cell line cell
An immortal pericardium-derived fibroblast cell line cell that derives from human.
immortal human pericardium-derived fibroblast cell line cell
An immortal embryo-derived cell line cell that derives from cat.
immortal cat embryo-derived cell line cell
An immortal embryo-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit embryo-derived cell line cell
a cell growth where the cell is a cell line cell.
cell line cell growth
An immortal mononuclear phagocyte cell line cell that derives from cat.
immortal cat mononuclear phagocyte cell line cell
An immortal foetal structure-derived fibroblast cell line cell that derives from human.
immortal human foetal structure-derived fibroblast cell line cell
An immortal external genitalia-derived fibroblast cell line cell that derives from human.
immortal human external genitalia-derived fibroblast cell line cell
An immortal prostate gland-derived cell line cell that derives from rat.
immortal rat prostate gland-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from human.
Obsolete - many cell line cells were previously mistakenly assigned under this class. Now no cell line cells available under this class.
obsolet immortal human septum of telencephalon-derived cell line cell
An immortal larva-derived cell line cell that derives from cabbage moth.
immortal cabbage moth larva-derived cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from human.
immortal human mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal kidney-derived cell line cell that derives from monkey.
immortal monkey kidney-derived cell line cell
An immortal lymphocyte cell line cell that derives from mouse.
immortal mouse lymphocyte cell line cell
An immortal lung-derived cell line cell that derives from human.
immortal human lung-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from mouse.
immortal mouse pair of lungs-derived cell line cell
An immortal area X-derived cell line cell that derives from mouse.
immortal mouse area X-derived cell line cell
An immortal area X-derived cell line cell that derives from Mus musculus x Rattus norvegicus.
immortal Mus musculus x Rattus norvegicus area X-derived cell line cell
An immortal somatic nervous system-derived cell line cell that derives from Chinese hamster.
immortal Chinese hamster somatic nervous system-derived cell line cell
a hybridoma cell line cell that is established by fusing cells from a mouse and a rat.
mouse x rat hybridoma cell line cell
An immortal fibroblast cell line cell that derives from mouse.
immortal mouse fibroblast cell line cell
An immortal cell line cell that derives from common quail.
An immortal lymph-derived cell line cell that derives from mouse.
immortal mouse lymph-derived cell line cell
An immortal multi-cellular organism-derived cell line cell that derives from mouse.
immortal mouse multi-cellular organism-derived cell line cell
An immortal embryo-derived cell line cell that derives from mouse.
immortal mouse embryo-derived cell line cell
An immortal embryo-derived cell line cell that derives from turnip moth.
immortal turnip moth embryo-derived cell line cell
An immortal thoracic aorta-derived endothelial cell line cell that derives from cattle.
immortal cattle thoracic aorta-derived endothelial cell line cell
An immortal lung-derived fibroblast cell line cell that derives from cattle.
immortal cattle lung-derived fibroblast cell line cell
An immortal thoracic aorta-derived smooth muscle cell line cell that derives from cattle.
immortal cattle thoracic aorta-derived smooth muscle cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from cattle.
immortal cattle thigh-derived fibroblast cell line cell
An immortal thoracic aorta-derived smooth muscle cell line cell that derives from pig.
immortal pig thoracic aorta-derived smooth muscle cell line cell
An immortal induced T-regulatory cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster induced T-regulatory cell line cell
An immortal liver-derived cell line cell that derives from rat.
immortal rat liver-derived cell line cell
An immortal colon-derived cell line cell that derives from human.
immortal human colon-derived cell line cell
An immortal caecum-derived cell line cell that derives from human.
immortal human caecum-derived cell line cell
An immortal pancreas-derived cell line cell that derives from mouse.
immortal mouse pancreas-derived cell line cell
An immortal lung-derived fibroblast cell line cell that derives from pig-tailed macaque.
immortal pig-tailed macaque lung-derived fibroblast cell line cell
An immortal brain-derived cell line cell that derives from human.
immortal human brain-derived cell line cell
An immortal trophoblast cell line cell that derives from human.
immortal human trophoblast cell line cell
An immortal tail-derived cell line cell that derives from mouse.
immortal mouse tail-derived cell line cell
An immortal skin-derived cell line cell that derives from mouse.
immortal mouse skin-derived cell line cell
An immortal collecting duct of renal tubule-derived cell line cell that derives from mouse.
immortal mouse collecting duct of renal tubule-derived cell line cell
An immortal myeloblast cell line cell that derives from mouse.
immortal mouse myeloblast cell line cell
An immortal peripheral neuron cell line cell that derives from human.
immortal human peripheral neuron cell line cell
An immortal arm-derived fibroblast cell line cell that derives from pig-tailed macaque.
immortal pig-tailed macaque arm-derived fibroblast cell line cell
An immortal thoracic aorta-derived smooth muscle cell line cell that derives from pig-tailed macaque.
immortal pig-tailed macaque thoracic aorta-derived smooth muscle cell line cell
An immortal mesonephros-derived cell line cell that derives from mouse.
immortal mouse mesonephros-derived cell line cell
An immortal female gonad-derived cell line cell that derives from Chinese hamster.
immortal Chinese hamster female gonad-derived cell line cell
An immortal chorion-derived cell line cell that derives from human.
immortal human chorion-derived cell line cell
An immortal thoracic aorta-derived smooth muscle cell line cell that derives from horse.
immortal horse thoracic aorta-derived smooth muscle cell line cell
An immortal lymphoid follicle-derived cell line cell that derives from mouse.
immortal mouse lymphoid follicle-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster fetal membrane-derived cell line cell
An immortal cell line cell that derives from vervet monkey.
An immortal kidney-derived cell line cell that derives from vervet monkey.
immortal vervet monkey kidney-derived cell line cell
An immortal mast cell line cell that derives from mouse.
An immortal epithelial cell line cell that derives from mouse.
immortal mouse epithelial cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from mouse.
immortal mouse mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal liver-derived cell line cell that derives from mouse.
immortal mouse liver-derived cell line cell
An immortal embryo-derived cell line cell that derives from Drosophila melanogaster.
immortal Drosophila melanogaster embryo-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from human.
immortal human fetal membrane-derived cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from fathead minnow.
immortal fathead minnow mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal multi-cellular organism-derived cell line cell that derives from human.
immortal human multi-cellular organism-derived cell line cell
An immortal spleen-derived cell line cell that derives from mouse.
immortal mouse spleen-derived cell line cell
An immortal kidney-derived cell line cell that derives from mouse.
immortal mouse kidney-derived cell line cell
An immortal leg-derived fibroblast cell line cell that derives from human.
immortal human leg-derived fibroblast cell line cell
An immortal female gonad-derived cell line cell that derives from mouse.
immortal mouse female gonad-derived cell line cell
An immortal limb/fin-derived cell line cell that derives from mouse.
immortal mouse limb/fin-derived cell line cell
An immortal testis-derived cell line cell that derives from mouse.
immortal mouse testis-derived cell line cell
An immortal arm-derived fibroblast cell line cell that derives from rhesus macaque.
immortal rhesus macaque arm-derived fibroblast cell line cell
An immortal stomach-derived cell line cell that derives from human.
immortal human stomach-derived cell line cell
An immortal abdominal cavity-derived fibroblast cell line cell that derives from human.
immortal human abdominal cavity-derived fibroblast cell line cell
An immortal pancreas-derived cell line cell that derives from human.
immortal human pancreas-derived cell line cell
An immortal thoracic aorta-derived endothelial cell line cell that derives from horse.
immortal horse thoracic aorta-derived endothelial cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from horse.
immortal horse thigh-derived fibroblast cell line cell
An immortal lung-derived fibroblast cell line cell that derives from horse.
immortal horse lung-derived fibroblast cell line cell
An immortal endothelium-derived cell line cell that derives from mouse.
immortal mouse endothelium-derived cell line cell
An immortal foreskin-derived fibroblast cell line cell that derives from human.
immortal human foreskin-derived fibroblast cell line cell
An immortal thoracic aorta-derived smooth muscle cell line cell that derives from rhesus macaque.
immortal rhesus macaque thoracic aorta-derived smooth muscle cell line cell
An immortal lung-derived fibroblast cell line cell that derives from rhesus macaque.
immortal rhesus macaque lung-derived fibroblast cell line cell
An immortal achilles tendon-derived fibroblast cell line cell that derives from human.
immortal human achilles tendon-derived fibroblast cell line cell
An immortal bone element-derived cell line cell that derives from human.
immortal human bone element-derived cell line cell
An immortal cell line cell that derives from rat.
An immortal thyroid gland-derived cell line cell that derives from rat.
immortal rat thyroid gland-derived cell line cell
An immortal epithelial cell line cell that derives from human.
immortal human epithelial cell line cell
An immortal urinary bladder-derived cell line cell that derives from human.
immortal human urinary bladder-derived cell line cell
An immortal liver-derived cell line cell that derives from human.
immortal human liver-derived cell line cell
An immortal acetabular part of hip bone-derived cell line cell that derives from human.
immortal human acetabular part of hip bone-derived cell line cell
An immortal cell line cell that derives from Ovis.
An immortal pair of lungs-derived cell line cell that derives from gray fox.
immortal gray fox pair of lungs-derived cell line cell
An immortal breast-derived cell line cell that derives from mouse.
immortal mouse breast-derived cell line cell
An immortal cell line cell that derives from rhesus macaque.
An immortal fetal membrane-derived cell line cell that derives from rhesus macaque.
immortal rhesus macaque fetal membrane-derived cell line cell
An immortal epithelium-derived cell line cell that derives from human.
immortal human epithelium-derived cell line cell
An immortal kidney-derived cell line cell that derives from dog.
immortal dog kidney-derived cell line cell
An immortal kidney-derived cell line cell that derives from cattle.
immortal cattle kidney-derived cell line cell
An immortal comma-shaped body-derived cell line cell that derives from human.
immortal human comma-shaped body-derived cell line cell
An immortal kidney-derived cell line cell that derives from sheep.
immortal sheep kidney-derived cell line cell
An immortal lymphocyte cell line cell that derives from turkey.
immortal turkey lymphocyte cell line cell
An immortal breast-derived cell line cell that derives from human.
immortal human breast-derived cell line cell
An immortal spleen-derived cell line cell that derives from human.
immortal human spleen-derived cell line cell
An immortal supra-orbital vein-derived cell line cell that derives from human.
immortal human supra-orbital vein-derived cell line cell
An immortal muscle cell line cell that derives from mouse.
An immortal ear-derived fibroblast cell line cell that derives from human.
immortal human ear-derived fibroblast cell line cell
An immortal inguinal region-derived fibroblast cell line cell that derives from human.
immortal human inguinal region-derived fibroblast cell line cell
An immortal mesothelium-derived cell line cell that derives from human.
immortal human mesothelium-derived cell line cell
An immortal uterus-derived cell line cell that derives from human.
immortal human uterus-derived cell line cell
An immortal endometrium-derived cell line cell that derives from human.
immortal human endometrium-derived cell line cell
An immortal kidney-derived cell line cell that derives from human.
immortal human kidney-derived cell line cell
An immortal fibroblast cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster fibroblast cell line cell
An immortal fibroblast cell line cell that derives from rat.
An immortal pair of lungs-derived cell line cell that derives from Mustelinae.
immortal Mustelinae pair of lungs-derived cell line cell
An immortal brain-derived cell line cell that derives from mouse.
immortal mouse brain-derived cell line cell
An immortal cell line cell that derives from chicken.
An immortal cell line cell that derives from Mus musculus x Rattus norvegicus.
immortal Mus musculus x Rattus norvegicus cell line cell
An immortal kidney-derived cell line cell that derives from pig.
immortal pig kidney-derived cell line cell
An immortal peripheral neuron cell line cell that derives from cat.
immortal cat peripheral neuron cell line cell
An immortal uterine cervix-derived cell line cell that derives from human.
immortal human uterine cervix-derived cell line cell
An immortal heart-derived cell line cell that derives from human.
immortal human heart-derived cell line cell
An immortal pituitary gland-derived cell line cell that derives from rat.
immortal rat pituitary gland-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from Mongolian gerbil.
immortal Mongolian gerbil pair of lungs-derived cell line cell
An immortal cell line cell that derives from sheep.
An immortal pair of lungs-derived cell line cell that derives from gecko.
immortal gecko pair of lungs-derived cell line cell
An immortal urinary bladder-derived cell line cell that derives from mouse.
immortal mouse urinary bladder-derived cell line cell
An immortal gill-derived cell line cell that derives from walking catfish.
immortal walking catfish gill-derived cell line cell
An immortal tongue-derived cell line cell that derives from bullfrog.
immortal bullfrog tongue-derived cell line cell
An immortal follicular fluid-derived cell line cell that derives from human.
immortal human follicular fluid-derived cell line cell
An immortal female gonad-derived cell line cell that derives from human.
immortal human female gonad-derived cell line cell
An immortal thyroid gland-derived cell line cell that derives from human.
immortal human thyroid gland-derived cell line cell
An immortal eye-derived cell line cell that derives from torafugu.
immortal torafugu eye-derived cell line cell
An immortal spermatocyte cell line cell that derives from mouse.
immortal mouse spermatocyte cell line cell
An immortal embryo-derived cell line cell that derives from chicken.
immortal chicken embryo-derived cell line cell
An immortal brain-derived cell line cell that derives from cat.
immortal cat brain-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from mouse.
immortal mouse fetal membrane-derived cell line cell
An immortal organism part-derived plasma cell line cell that derives from mouse.
immortal mouse organism part-derived plasma cell line cell
An immortal floating rib-derived cell line cell that derives from human.
immortal human floating rib-derived cell line cell
An immortal urinary bladder-derived cell line cell that derives from rat.
immortal rat urinary bladder-derived cell line cell
An immortal mammary gland-derived cell line cell that derives from mouse.
immortal mouse mammary gland-derived cell line cell
An immortal blood cell line cell that derives from human.
An immortal megakaryocyte-erythroid progenitor cell line cell that derives from mouse.
immortal mouse megakaryocyte-erythroid progenitor cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from Mustelinae.
immortal Mustelinae septum of telencephalon-derived cell line cell
An immortal colon-derived cell line cell that derives from guinea pig.
immortal guinea pig colon-derived cell line cell
An immortal thorax-derived fibroblast cell line cell that derives from human.
immortal human thorax-derived fibroblast cell line cell
An immortal paired fin-derived cell line cell that derives from bluestriped grunt.
immortal bluestriped grunt paired fin-derived cell line cell
An immortal neural nucleus-derived cell line cell that derives from rat.
immortal rat neural nucleus-derived cell line cell
An immortal Ammon's horn-derived cell line cell that derives from rat.
immortal rat Ammon's horn-derived cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from sheep.
immortal sheep organism part-derived fibroblast cell line cell
An immortal brain-derived cell line cell that derives from ferret.
immortal ferret brain-derived cell line cell
An immortal bone marrow-derived cell line cell that derives from mouse.
immortal mouse bone marrow-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from mouse.
immortal mouse septum of telencephalon-derived cell line cell
An immortal islet of Langerhans-derived cell line cell that derives from mouse.
immortal mouse islet of Langerhans-derived cell line cell
An immortal kidney-derived cell line cell that derives from Miopithecus talapoin.
immortal Miopithecus talapoin kidney-derived cell line cell
An immortal kidney-derived cell line cell that derives from budgerigar.
immortal budgerigar kidney-derived cell line cell
An immortal thyroid gland-derived cell line cell that derives from mouse.
immortal mouse thyroid gland-derived cell line cell
An immortal pyramid of medulla oblongata-derived cell line cell that derives from human.
immortal human pyramid of medulla oblongata-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from squamate.
immortal squamate pair of lungs-derived cell line cell
An immortal aorta-derived cell line cell that derives from mouse.
immortal mouse aorta-derived cell line cell
An immortal uterine cervix-derived epithelial cell line cell that derives from human.
immortal human uterine cervix-derived epithelial cell line cell
An immortal ileocecal junction-derived cell line cell that derives from human.
immortal human ileocecal junction-derived cell line cell
An immortal compact bone-derived cell line cell that derives from human.
immortal human compact bone-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from rat.
immortal rat septum of telencephalon-derived cell line cell
An immortal abdominal aorta-derived cell line cell that derives from human.
immortal human abdominal aorta-derived cell line cell
An immortal bronchus-derived cell line cell that derives from human.
immortal human bronchus-derived cell line cell
An immortal kidney-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster kidney-derived cell line cell
An immortal pancreas-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster pancreas-derived cell line cell
An immortal cell line cell that derives from horse.
An immortal organism part-derived keratinocyte cell line cell that derives from human.
immortal human organism part-derived keratinocyte cell line cell
An immortal iliac artery-derived cell line cell that derives from human.
immortal human iliac artery-derived cell line cell
An immortal synovial membrane of synovial joint-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit synovial membrane of synovial joint-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster septum of telencephalon-derived cell line cell
An immortal female gonad-derived cell line cell that derives from Himalayan Tahr.
immortal Himalayan Tahr female gonad-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from Himalayan Tahr.
immortal Himalayan Tahr fetal membrane-derived cell line cell
An immortal iliac vein-derived cell line cell that derives from human.
immortal human iliac vein-derived cell line cell
An immortal B cell line cell that derives from human.
immortal human B-cell line cell
An immortal vagina-derived cell line cell that derives from human.
immortal human vagina-derived cell line cell
An immortal larynx-derived cell line cell that derives from human.
immortal human larynx-derived cell line cell
An immortal inferior cervical ganglion-derived cell line cell that derives from human.
immortal human inferior cervical ganglion-derived cell line cell
An immortal esophagus-derived cell line cell that derives from human.
immortal human esophagus-derived cell line cell
An immortal femoral artery-derived cell line cell that derives from human.
immortal human femoral artery-derived cell line cell
An immortal prepuce of penis-derived cell line cell that derives from human.
immortal human prepuce of penis-derived cell line cell
An immortal gingival epithelium-derived cell line cell that derives from human.
immortal human gingival epithelium-derived cell line cell
An immortal gingiva-derived cell line cell that derives from human.
immortal human gingiva-derived cell line cell
An immortal muscle cell line cell that derives from human.
An immortal thymus-derived cell line cell that derives from human.
immortal human thymus-derived cell line cell
An immortal mouth-derived cell line cell that derives from human.
immortal human mouth-derived cell line cell
An immortal neuron cell line cell that derives from rat.
An immortal limb/fin-derived cell line cell that derives from human.
immortal human limb/fin-derived cell line cell
An immortal leukocyte cell line cell that derives from marmoset.
immortal marmoset leukocyte cell line cell
An immortal peritoneal macrophage cell line cell that derives from Chinese hamster.
immortal Chinese hamster peritoneal macrophage cell line cell
An immortal peritoneum-derived cell line cell that derives from Chinese hamster.
immortal Chinese hamster peritoneum-derived cell line cell
An immortal peripheral vein-derived cell line cell that derives from human.
immortal human peripheral vein-derived cell line cell
An immortal brain-derived cell line cell that derives from rat.
immortal rat brain-derived cell line cell
An immortal exocrine cell line cell that derives from rat.
An immortal kidney-derived cell line cell that derives from Atlantic salmon.
immortal Atlantic salmon kidney-derived cell line cell
An immortal round window-derived cell line cell that derives from mouse.
immortal mouse round window-derived cell line cell
An immortal female gonad-derived cell line cell that derives from moth.
immortal moth female gonad-derived cell line cell
An immortal female gonad-derived cell line cell that derives from Antheraea.
immortal Antheraea female gonad-derived cell line cell
An immortal conjunctiva structure-derived fibroblast cell line cell that derives from human.
immortal human conjunctiva structure-derived fibroblast cell line cell
An immortal pancreas-derived cell line cell that derives from rat.
immortal rat pancreas-derived cell line cell
An immortal dento-alveolar joint-derived cell line cell that derives from human.
immortal human dento-alveolar joint-derived cell line cell
An immortal testis-derived cell line cell that derives from human.
immortal human testis-derived cell line cell
An immortal intestine-derived cell line cell that derives from human.
immortal human intestine-derived cell line cell
An immortal rectum-derived cell line cell that derives from human.
immortal human rectum-derived cell line cell
An immortal pulmonary vein-derived cell line cell that derives from human.
immortal human pulmonary vein-derived cell line cell
An immortal islet of Langerhans-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster islet of Langerhans-derived cell line cell
An immortal buttock-derived fibroblast cell line cell that derives from human.
immortal human buttock-derived fibroblast cell line cell
An immortal tonsil-derived cell line cell that derives from human.
immortal human tonsil-derived cell line cell
An immortal thymus-derived cell line cell that derives from mouse.
immortal mouse thymus-derived cell line cell
An immortal umbilicus-derived fibroblast cell line cell that derives from human.
immortal human umbilicus-derived fibroblast cell line cell
An immortal larva-derived cell line cell that derives from mosquito.
immortal mosquito larva-derived cell line cell
An immortal thoracic aorta-derived endothelial cell line cell that derives from pig.
immortal pig thoracic aorta-derived endothelial cell line cell
An immortal kidney-derived cell line cell that derives from African clawed frog.
immortal African clawed frog kidney-derived cell line cell
An immortal cell line cell that derives from dog.
An immortal dento-alveolar joint-derived cell line cell that derives from mouse.
immortal mouse dento-alveolar joint-derived cell line cell
An immortal posterior commissure-derived cell line cell that derives from zebra fish.
immortal zebra fish posterior commissure-derived cell line cell
An immortal soft palate-derived cell line cell that derives from human.
immortal human soft palate-derived cell line cell
An immortal cell line cell that derives from silk moth.
An immortal kidney-derived cell line cell that derives from hamster.
immortal hamster kidney-derived cell line cell
An immortal adrenal gland-derived cell line cell that derives from human.
immortal human adrenal gland-derived cell line cell
An immortal pronephros-derived cell line cell that derives from mouse.
immortal mouse pronephros-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from rat.
immortal rat fetal membrane-derived cell line cell
An immortal organism part-derived smooth muscle cell line cell that derives from human.
immortal human organism part-derived smooth muscle cell line cell
An immortal blood cell line cell that derives from mouse.
An immortal placenta-derived cell line cell that derives from human.
immortal human placenta-derived cell line cell
An immortal posterior commissure-derived cell line cell that derives from bluegill sunfish.
immortal bluegill sunfish posterior commissure-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from cattle.
immortal cattle septum of telencephalon-derived cell line cell
An immortal embryo-derived cell line cell that derives from gastropod.
immortal gastropod embryo-derived cell line cell
An immortal ON-bipolar cell line cell that derives from mouse.
immortal mouse ON-bipolar cell line cell
An immortal pair of lungs-derived cell line cell that derives from kusimanse.
immortal kusimanse pair of lungs-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from Oryx.
immortal Oryx pair of lungs-derived cell line cell
An immortal kidney-derived cell line cell that derives from Burchell's zebra.
immortal Burchell's zebra kidney-derived cell line cell
An immortal embryo-derived cell line cell that derives from plantain squirrel.
immortal plantain squirrel embryo-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from sheep.
immortal sheep fetal membrane-derived cell line cell
An immortal brain-derived cell line cell that derives from sheep.
immortal sheep brain-derived cell line cell
An immortal kidney-derived cell line cell that derives from Silvery marmoset.
immortal Silvery marmoset kidney-derived cell line cell
An immortal kidney-derived cell line cell that derives from rhesus macaque.
immortal rhesus macaque kidney-derived cell line cell
An immortal monocyte cell line cell that derives from mouse.
An immortal neural nucleus-derived cell line cell that derives from Mus musculus x Rattus norvegicus.
immortal Mus musculus x Rattus norvegicus neural nucleus-derived cell line cell
An immortal sublingual artery-derived cell line cell that derives from cat.
immortal cat sublingual artery-derived cell line cell
An immortal female gonad-derived cell line cell that derives from cat.
immortal cat female gonad-derived cell line cell
An immortal round window-derived cell line cell that derives from Mus musculus x Rattus norvegicus.
immortal Mus musculus x Rattus norvegicus round window-derived cell line cell
An immortal thyrotroph cell line cell that derives from mouse.
immortal mouse thyrotroph cell line cell
An immortal pair of lungs-derived cell line cell that derives from rat.
immortal rat pair of lungs-derived cell line cell
An immortal kidney-derived cell line cell that derives from rat.
immortal rat kidney-derived cell line cell
An immortal aorta-derived cell line cell that derives from cattle.
immortal cattle aorta-derived cell line cell
An immortal cell line cell that derives from Chinese oak silkmoth.
immortal Chinese oak silkmoth cell line cell
An immortal endothelium-derived cell line cell that derives from cattle.
immortal cattle endothelium-derived cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from brown bullhead.
immortal brown bullhead mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal bone marrow-derived cell line cell that derives from cattle.
immortal cattle bone marrow-derived cell line cell
An immortal macrophage cell line cell that derives from mouse.
immortal mouse macrophage cell line cell
An immortal ligament-derived cell line cell that derives from mouse.
immortal mouse ligament-derived cell line cell
An immortal uterus-derived fibroblast cell line cell that derives from human.
immortal human uterus-derived fibroblast cell line cell
An immortal uterus-derived cell line cell that derives from northern raccoon.
immortal northern raccoon uterus-derived cell line cell
An immortal thyroid gland-derived cell line cell that derives from sheep.
immortal sheep thyroid gland-derived cell line cell
An immortal peripheral neuron cell line cell that derives from channel catfish.
immortal channel catfish peripheral neuron cell line cell
An immortal animal ovary-derived fibroblast cell line cell that derives from human.
immortal human ovary-derived fibroblast cell line cell
An immortal kidney-derived cell line cell that derives from Aotus.
immortal Aotus kidney-derived cell line cell
An immortal cerebral lobe-derived cell line cell that derives from crayfish.
immortal crayfish cerebral lobe-derived cell line cell
An immortal B cell line cell that derives from chicken.
immortal chicken B cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from American opossum.
immortal American opossum septum of telencephalon-derived cell line cell
An immortal kidney-derived cell line cell that derives from black-tailed deer.
immortal black-tailed deer kidney-derived cell line cell
An immortal liver-derived cell line cell that derives from black-tailed deer.
immortal black-tailed deer liver-derived cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from black-tailed deer.
immortal black-tailed deer mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal vasculature-derived cell line cell that derives from mouse.
immortal mouse vasculature-derived cell line cell
An immortal larva-derived cell line cell that derives from Pacific herring.
immortal Pacific herring larva-derived cell line cell
An immortal cell line cell that derives from pig.
An immortal kidney-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit kidney-derived cell line cell
An immortal liver-derived cell line cell that derives from topminnow.
immortal topminnow liver-derived cell line cell
An immortal thyroid gland-derived cell line cell that derives from pig.
immortal pig thyroid gland-derived cell line cell
An immortal prostate gland-derived cell line cell that derives from human.
immortal human prostate gland-derived cell line cell
An immortal squamous part of temporal bone-derived cell line cell that derives from human.
immortal human squamous part of temporal bone-derived cell line cell
An immortal kidney-derived cell line cell that derives from peccary.
immortal peccary kidney-derived cell line cell
An immortal female gonad-derived cell line cell that derives from northern pike.
immortal northern pike female gonad-derived cell line cell
An immortal pronephros-derived fibroblast cell line cell that derives from human.
immortal human pronephros-derived fibroblast cell line cell
An immortal adrenal gland-derived cell line cell that derives from rat.
immortal rat adrenal gland-derived cell line cell
An immortal precursor B cell line cell that derives from mouse.
immortal mouse precursor B cell line cell
An immortal mucosa-derived cell line cell that derives from pig.
immortal pig mucosa-derived cell line cell
An immortal kidney-derived cell line cell that derives from Potoroo.
immortal Potoroo kidney-derived cell line cell
An immortal embryo-derived cell line cell that derives from swordtail platyfish.
immortal swordtail platyfish embryo-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from Chinese hamster.
immortal Chinese hamster pair of lungs-derived cell line cell
An immortal epidermis-derived cell line cell that derives from human.
immortal human epidermis-derived cell line cell
An immortal submandibular gland-derived cell line cell that derives from human.
immortal human submandibular gland-derived cell line cell
An immortal lung-derived mesothelial cell line cell that derives from rat.
immortal rat lung-derived mesothelial cell line cell
An immortal lung-derived mesothelial cell line cell that derives from cattle.
immortal cattle lung-derived mesothelial cell line cell
An immortal eye structure-derived epithelial cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit eye structure-derived epithelial cell line cell
An immortal hip-derived fibroblast cell line cell that derives from human.
immortal human hip-derived fibroblast cell line cell
An immortal parietal cell line cell that derives from mouse.
An immortal prostate epithelium-derived cell line cell that derives from human.
immortal human prostate epithelium-derived cell line cell
An immortal retinal neural layer-derived cell line cell that derives from Japanese quail.
immortal Japanese quail retinal neural layer-derived cell line cell
An immortal fibroblast cell line cell that derives from Japanese quail.
immortal Japanese quail fibroblast cell line cell
An immortal testis-derived cell line cell that derives from rat.
immortal rat testis-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit pair of lungs-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from rhesus macaque.
immortal rhesus macaque septum of telencephalon-derived cell line cell
An immortal ureter-derived cell line cell that derives from human.
immortal human ureter-derived cell line cell
An immortal pyramid of medulla oblongata-derived cell line cell that derives from rat.
immortal rat pyramid of medulla oblongata-derived cell line cell
An immortal iliac vein-derived smooth muscle cell line cell that derives from human.
immortal human iliac vein-derived smooth muscle cell line cell
An immortal common iliac artery-derived smooth muscle cell line cell that derives from human.
immortal human common iliac artery-derived smooth muscle cell line cell
An immortal mammary gland-derived keratinocyte cell line cell that derives from human.
immortal human mammary gland-derived keratinocyte cell line cell
An immortal skin-derived fibroblast cell line cell that derives from pig.
immortal pig skin-derived fibroblast cell line cell
An immortal lung-derived fibroblast cell line cell that derives from pig.
immortal pig lung-derived fibroblast cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from Chinese hamster.
immortal Chinese hamster organism part-derived fibroblast cell line cell
An immortal umbilical vein-derived endothelial cell line cell that derives from human.
immortal human umbilical vein-derived endothelial cell line cell
An immortal scalp-derived fibroblast cell line cell that derives from human.
immortal human scalp-derived fibroblast cell line cell
An immortal organism part-derived cell line cell that derives from chimpanzee.
immortal chimpanzee organism part-derived cell line cell
An immortal skeletal muscle-derived myoblast cell line cell that derives from chimpanzee.
immortal chimpanzee skeletal muscle-derived myoblast cell line cell
An immortal organism part-derived endothelial cell line cell that derives from chimpanzee.
immortal chimpanzee organism part-derived endothelial cell line cell
An immortal embryo-derived fibroblast cell line cell that derives from mouse.
immortal mouse embryo-derived fibroblast cell line cell
An immortal sacrum-derived fibroblast cell line cell that derives from human.
immortal human sacrum-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from hamadryas baboon.
immortal hamadryas baboon skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from vervet monkey.
immortal vervet monkey skin-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from siamang.
immortal siamang peripheral vein-derived B cell line cell
An immortal skin-derived fibroblast cell line cell that derives from king colobus.
immortal king colobus skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from South American squirrel monkey.
immortal South American squirrel monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Francois's langur.
immortal Francois's langur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from agile mangabey.
immortal agile mangabey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from gray-cheeked mangabey.
immortal gray-cheeked mangabey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from cotton-top tamarin.
immortal cotton-top tamarin skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from black-cheeked white-nosed monkey.
immortal black-cheeked white-nosed monkey skin-derived fibroblast cell line cell
An immortal shoulder-derived fibroblast cell line cell that derives from Midas tamarin.
immortal Midas tamarin shoulder-derived fibroblast cell line cell
An immortal hip-derived fibroblast cell line cell that derives from Midas tamarin.
immortal Midas tamarin hip-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from golden-crowned sifaka.
immortal golden-crowned sifaka thigh-derived fibroblast cell line cell
An immortal arm-derived fibroblast cell line cell that derives from Midas tamarin.
immortal Midas tamarin arm-derived fibroblast cell line cell
An immortal placenta-derived fibroblast cell line cell that derives from human.
immortal human placenta-derived fibroblast cell line cell
An immortal dermis-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster dermis-derived cell line cell
An immortal embryo-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster embryo-derived cell line cell
An immortal cornea-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit cornea-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit septum of telencephalon-derived cell line cell
An immortal mammalian vulva-derived cell line cell that derives from human.
immortal human mammalian vulva-derived cell line cell
An immortal spherical lensed eye-derived cell line cell that derives from human.
immortal human spherical lensed eye-derived cell line cell
An immortal aorta-derived cell line cell that derives from rat.
immortal rat aorta-derived cell line cell
An immortal skeletal muscle-derived myoblast cell line cell that derives from human.
immortal human skeletal muscle-derived myoblast cell line cell
An immortal ileum-derived cell line cell that derives from pig.
immortal pig ileum-derived cell line cell
An immortal larva-derived cell line cell that derives from gypsy moth.
immortal gypsy moth larva-derived cell line cell
An immortal female gonad-derived cell line cell that derives from gypsy moth.
immortal gypsy moth female gonad-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from African buffalo.
immortal African buffalo lung-derived cell line cell
An immortal fibroblast cell line cell that derives from Mongolian gerbil.
immortal Mongolian gerbil fibroblast cell line cell
An immortal skin-derived cell line cell that derives from Muntjacs.
immortal Muntjacs skin-derived cell line cell
An immortal cervix-derived fibroblast cell line cell that derives from human.
immortal human cervix-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from brown lemur.
immortal brown lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Wolf's monkey.
immortal Wolf's monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from mandrill.
immortal mandrill skin-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from Red-cheeked gibbon.
immortal Red-cheeked gibbon peripheral vein-derived B cell line cell
An immortal skin-derived fibroblast cell line cell that derives from red-crowned mangabey.
immortal red-crowned mangabey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Bolivian squirrel monkey.
immortal Bolivian squirrel monkey skin-derived fibroblast cell line cell
An immortal abdominal cavity-derived fibroblast cell line cell that derives from rhesus macaque.
immortal rhesus macaque abdominal cavity-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from brown woolly monkey.
immortal brown woolly monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from moustached monkey.
immortal moustached monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Moholi bushbaby.
immortal Moholi bushbaby skin-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from Celebes crested macaque.
immortal Celebes crested macaque thigh-derived fibroblast cell line cell
An immortal rhomboid-derived myoblast cell line cell that derives from human.
immortal human rhomboid-derived myoblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from crowned lemur.
immortal crowned lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from white sifaka.
immortal white sifaka skin-derived fibroblast cell line cell
An immortal thorax-derived fibroblast cell line cell that derives from drill.
immortal drill thorax-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from white-faced saki.
immortal white-faced saki skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from aye-aye.
immortal aye-aye skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from bamboo lemur.
immortal bamboo lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Goeldi's monkey.
immortal Goeldi's monkey skin-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from Bornean orangutan.
immortal Bornean orangutan peripheral vein-derived B cell line cell
An immortal peripheral vein-derived B cell line cell that derives from pileated gibbon.
immortal pileated gibbon peripheral vein-derived B cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from dog.
immortal dog organism part-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Bolivian red howler monkey.
immortal Bolivian red howler monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Miopithecus talapoin.
immortal Miopithecus talapoin skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Pere David's macaque.
immortal Pere David's macaque skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from White-cheeked Gibbon.
immortal White-cheeked Gibbon skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from saddlebacked tamarin.
immortal saddlebacked tamarin skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from L'Hoest's monkey.
immortal L'Hoest's monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from proboscis monkey.
immortal proboscis monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from pygmy marmoset.
immortal pygmy marmoset skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Spix's night monkey.
immortal Spix's night monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Nancy Ma's night monkey.
immortal Nancy Ma's night monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from slow loris.
immortal slow loris skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Lesser dwarf lemur.
immortal Lesser dwarf lemur skin-derived fibroblast cell line cell
An immortal abdominal cavity-derived cell line cell that derives from human.
immortal human abdominal cavity-derived cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Red-bellied titi.
immortal Red-bellied titi skin-derived fibroblast cell line cell
An immortal vasculature-derived cell line cell that derives from human.
immortal human vasculature-derived cell line cell
An immortal umbilical vein-derived cell line cell that derives from human.
immortal human umbilical vein-derived cell line cell
An immortal duodenum-derived cell line cell that derives from human.
immortal human duodenum-derived cell line cell
An immortal blood cell line cell that derives from marmoset.
An immortal skin-derived fibroblast cell line cell that derives from Coquerel's mouse lemur.
immortal Coquerel's mouse lemur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from lesser white-nosed monkey.
immortal lesser white-nosed monkey skin-derived fibroblast cell line cell
An immortal ileum-derived cell line cell that derives from rat.
immortal rat ileum-derived cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Yellow baboon.
immortal Yellow baboon skin-derived fibroblast cell line cell
An immortal embryo-derived cell line cell that derives from Neobatrachia.
immortal Neobatrachia embryo-derived cell line cell
An immortal skin-derived fibroblast cell line cell that derives from blue monkey.
immortal blue monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Celebes crested macaque.
immortal Celebes crested macaque skin-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from agile gibbon.
immortal agile gibbon peripheral vein-derived B cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Hanuman langur.
immortal Hanuman langur skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Geoffroy's marmoset.
immortal Geoffroy's marmoset skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from coppery titi.
immortal coppery titi skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from slender loris.
immortal slender loris skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from liontail macaque.
immortal liontail macaque skin-derived fibroblast cell line cell
An immortal connective tissue-derived cell line cell that derives from human.
immortal human connective tissue-derived cell line cell
An immortal bone marrow-derived cell line cell that derives from human.
immortal human bone marrow-derived cell line cell
An immortal parotid gland-derived cell line cell that derives from human.
immortal human parotid gland-derived cell line cell
An immortal cell line cell that derives from true toad.
An immortal skin-derived cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster skin-derived cell line cell
An immortal follicular fluid-derived cell line cell that derives from rat.
immortal rat follicular fluid-derived cell line cell
An immortal eye-derived cell line cell that derives from human.
immortal human eye-derived cell line cell
An immortal ischium-derived fibroblast cell line cell that derives from human.
immortal human ischium-derived fibroblast cell line cell
An immortal embryo-derived cell line cell that derives from zebra fish.
immortal zebra fish embryo-derived cell line cell
An immortal parenchymal cell line cell that derives from zebra fish.
immortal zebra fish parenchymal cell line cell
An immortal buttock-derived cell line cell that derives from human.
immortal human buttock-derived cell line cell
An immortal anatomical cluster-derived cell line cell that derives from human.
immortal human anatomical cluster-derived cell line cell
An immortal thigh-derived cell line cell that derives from human.
immortal human thigh-derived cell line cell
An immortal heart-derived cell line cell that derives from Iguana.
immortal Iguana heart-derived cell line cell
An immortal chordate pharynx-derived cell line cell that derives from human.
immortal human chordate pharynx-derived cell line cell
An immortal retina-derived cell line cell that derives from human.
immortal human retina-derived cell line cell
An immortal skin-derived cell line cell that derives from chimpanzee.
immortal chimpanzee skin-derived cell line cell
An immortal fibroblast cell line cell that derives from walleye.
immortal walleye fibroblast cell line cell
An immortal neural nucleus-derived cell line cell that derives from mouse.
immortal mouse neural nucleus-derived cell line cell
An immortal yolk sac-derived cell line cell that derives from mouse.
immortal mouse yolk sac-derived cell line cell
An immortal nasal concha-derived cell line cell that derives from cattle.
immortal cattle nasal concha-derived cell line cell
An immortal cell line cell that derives from tick.
An immortal female gonad-derived cell line cell that derives from silk moth.
immortal silk moth female gonad-derived cell line cell
An immortal arm-derived cell line cell that derives from human.
immortal human arm-derived cell line cell
An immortal peripheral vein-derived B cell line cell that derives from Kenya baboon.
immortal Kenya baboon peripheral vein-derived B cell line cell
An immortal sacrum-derived cell line cell that derives from human.
immortal human sacrum-derived cell line cell
An immortal conjunctiva-derived cell line cell that derives from human.
immortal human conjunctiva-derived cell line cell
An immortal epithelial cell line cell that derives from rat.
An immortal submandibular gland-derived cell line cell that derives from mouse.
immortal mouse submandibular gland-derived cell line cell
An immortal single nucleate cell line cell that derives from human.
immortal human single nucleate cell line cell
An immortal trachea-derived cell line cell that derives from human.
immortal human trachea-derived cell line cell
An immortal tongue-derived cell line cell that derives from human.
immortal human tongue-derived cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from pig.
immortal pig thigh-derived fibroblast cell line cell
An immortal trachea-derived cell line cell that derives from dog.
immortal dog trachea-derived cell line cell
An immortal thymus-derived cell line cell that derives from dog.
immortal dog thymus-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from bat.
immortal bat lung-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from free-tailed bat.
immortal free-tailed bat pair of lungs-derived cell line cell
An immortal urinary bladder-derived cell line cell that derives from Bufo.
immortal Bufo urinary bladder-derived cell line cell
An immortal dento-alveolar joint-derived cell line cell that derives from white-tufted-ear marmoset.
immortal white-tufted-ear marmoset dento-alveolar joint-derived cell line cell
An immortal skin-derived cell line cell that derives from anteater.
immortal anteater skin-derived cell line cell
An immortal aorta-derived cell line cell that derives from human.
immortal human aorta-derived cell line cell
An immortal lymphoid follicle-derived cell line cell that derives from human.
immortal human lymphoid follicle-derived cell line cell
An immortal bone element-derived cell line cell that derives from dog.
immortal dog bone element-derived cell line cell
An immortal respiration organ-derived cell line cell that derives from mouse.
immortal mouse respiration organ-derived cell line cell
An immortal fusion competent myoblast cell line cell that derives from human.
immortal human fusion competent myoblast cell line cell
An immortal female gonad-derived cell line cell that derives from channel catfish.
immortal channel catfish female gonad-derived cell line cell
An immortal muscle spindle-derived cell line cell that derives from mouse.
immortal mouse muscle spindle-derived cell line cell
An immortal testis-derived cell line cell that derives from pig.
immortal pig testis-derived cell line cell
An immortal embryo-derived cell line cell that derives from sockeye salmon.
immortal sockeye salmon embryo-derived cell line cell
An immortal renal glomerulus-derived cell line cell that derives from mouse.
immortal mouse renal glomerulus-derived cell line cell
An immortal liver-derived cell line cell that derives from rainbow trout.
immortal rainbow trout liver-derived cell line cell
An immortal nephron tubule-derived cell line cell that derives from Bolivian squirrel monkey.
immortal Bolivian squirrel monkey nephron tubule-derived cell line cell
An immortal larva-derived cell line cell that derives from silk moth.
immortal silk moth larva-derived cell line cell
An immortal sternum-derived cell line cell that derives from geese.
immortal geese sternum-derived cell line cell
An immortal neuron cell line cell that derives from mouse.
An immortal esophagus-derived cell line cell that derives from goat.
immortal goat esophagus-derived cell line cell
An immortal hypodermis-derived cell line cell that derives from human.
immortal human hypodermis-derived cell line cell
An immortal skin-derived cell line cell that derives from goat.
immortal goat skin-derived cell line cell
An immortal embryo-derived cell line cell that derives from Chinook salmon.
immortal Chinook salmon embryo-derived cell line cell
An immortal embryo-derived cell line cell that derives from Salmonidae.
immortal Salmonidae embryo-derived cell line cell
An immortal neuroblast cell line cell that derives from human.
immortal human neuroblast cell line cell
An immortal embryo-derived cell line cell that derives from Chinese hamster.
immortal Chinese hamster embryo-derived cell line cell
An immortal leukocyte cell line cell that derives from carp.
An immortal B cell line cell that derives from mouse.
immortal mouse B cell line cell
An immortal heart-derived cell line cell that derives from chum salmon.
immortal chum salmon heart-derived cell line cell
An immortal bone element-derived cell line cell that derives from rat.
immortal rat bone element-derived cell line cell
An immortal monocyte cell line cell that derives from human.
An immortal thorax-derived fibroblast cell line cell that derives from dog.
immortal dog thorax-derived fibroblast cell line cell
An immortal proximal tubule-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit proximal tubule-derived cell line cell
An immortal cell line cell that derives from Chinese hamster.
An immortal fibroblast cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit fibroblast cell line cell
An immortal kidney-derived cell line cell that derives from African green monkey polyomavirus.
immortal African green monkey polyomavirus kidney-derived cell line cell
An immortal aorta-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit aorta-derived cell line cell
An immortal dermis-derived cell line cell that derives from hagfish.
immortal hagfish dermis-derived cell line cell
An immortal embryo-derived cell line cell that derives from white bass.
immortal white bass embryo-derived cell line cell
An immortal colon-derived cell line cell that derives from rat.
immortal rat colon-derived cell line cell
An immortal liver-derived cell line cell that derives from woodchuck.
immortal woodchuck liver-derived cell line cell
An immortal mucosa of vagina-derived cell line cell that derives from human.
immortal human mucosa of vagina-derived cell line cell
An immortal heart-derived cell line cell that derives from Russell's viper.
immortal Russell's viper heart-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from Russell's viper.
immortal Russell's viper septum of telencephalon-derived cell line cell
An immortal fusion competent myoblast cell line cell that derives from rat.
immortal rat fusion competent myoblast cell line cell
An immortal heart-derived cell line cell that derives from Terrapene.
immortal Terrapene heart-derived cell line cell
An immortal cell line cell that derives from cabbage looper.
An immortal larva-derived cell line cell that derives from cabbage looper.
immortal cabbage looper larva-derived cell line cell
An immortal multi-cellular organism-derived cell line cell that derives from mosquito.
immortal mosquito multi-cellular organism-derived cell line cell
An immortal dento-alveolar joint-derived cell line cell that derives from rat.
immortal rat dento-alveolar joint-derived cell line cell
An immortal kidney-derived cell line cell that derives from rainbow trout.
immortal rainbow trout kidney-derived cell line cell
An immortal prostate gland-derived cell line cell that derives from mouse.
immortal mouse prostate gland-derived cell line cell
An immortal embryo-derived cell line cell that derives from rat.
immortal rat embryo-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from deer.
immortal deer pair of lungs-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from horse.
immortal horse septum of telencephalon-derived cell line cell
An immortal dermis-derived cell line cell that derives from horse.
immortal horse dermis-derived cell line cell
An immortal epithelial cell line cell that derives from dog.
An immortal skin-derived cell line cell that derives from camel.
immortal camel skin-derived cell line cell
An immortal embryo-derived cell line cell that derives from duck.
immortal duck embryo-derived cell line cell
An immortal fibroblast cell line cell that derives from dog.
An immortal hematopoietic cell line cell that derives from mouse.
immortal mouse hematopoietic cell line cell
An immortal skin-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit skin-derived cell line cell
An immortal blood cell line cell that derives from Gorilla.
An immortal trachea-derived cell line cell that derives from cattle.
immortal cattle trachea-derived cell line cell
An immortal blood cell line cell that derives from chimpanzee.
immortal chimpanzee blood cell line cell
An immortal blood cell line cell that derives from Sumatran orangutan.
immortal Sumatran orangutan blood cell line cell
An immortal larva-derived cell line cell that derives from Acrea moth.
immortal Acrea moth larva-derived cell line cell
An immortal endocervix-derived cell line cell that derives from human.
immortal human endocervix-derived cell line cell
An immortal adrenal gland-derived cell line cell that derives from cattle.
immortal cattle adrenal gland-derived cell line cell
An immortal cell line cell that derives from Dzhungarian hamster.
immortal Dzhungarian hamster cell line cell
An immortal testis-derived cell line cell that derives from dolphin.
immortal dolphin testis-derived cell line cell
An immortal cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster cell line cell
An immortal pair of lungs-derived cell line cell that derives from vervet monkey.
immortal vervet monkey pair of lungs-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from rhesus macaque.
immortal rhesus macaque pair of lungs-derived cell line cell
An immortal embryo-derived cell line cell that derives from Drosophila hydei.
immortal Drosophila hydei embryo-derived cell line cell
An immortal macrophage cell line cell that derives from dog.
An immortal fetal membrane-derived cell line cell that derives from Bolivian squirrel monkey.
immortal Bolivian squirrel monkey fetal membrane-derived cell line cell
An immortal trachea-derived cell line cell that derives from nine-banded armadillo.
immortal nine-banded armadillo trachea-derived cell line cell
An immortal arm-derived fibroblast cell line cell that derives from Ring-tailed lemur.
immortal Ring-tailed lemur arm-derived fibroblast cell line cell
An immortal organism part-derived mesothelial cell line cell that derives from human.
immortal human organism part-derived mesothelial cell line cell
An immortal arm-derived fibroblast cell line cell that derives from Celebes crested macaque.
immortal Celebes crested macaque arm-derived fibroblast cell line cell
An immortal embryo-derived cell line cell that derives from fruit fly.
immortal fruit fly embryo-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from dog.
immortal dog septum of telencephalon-derived cell line cell
An immortal cell line cell that derives from long-tailed macaque.
immortal long-tailed macaque cell line cell
An immortal cell line cell that derives from gold fish.
immortal gold fish cell line cell
An immortal cell line cell that derives from turnip moth.
An immortal skin-derived cell line cell that derives from Cottontail rabbit.
immortal Cottontail rabbit skin-derived cell line cell
An immortal colon-derived cell line cell that derives from mouse.
immortal mouse colon-derived cell line cell
An immortal fibroblast cell line cell that derives from coho salmon.
immortal coho salmon fibroblast cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from cat.
immortal cat septum of telencephalon-derived cell line cell
An immortal shoulder-derived fibroblast cell line cell that derives from human.
immortal human shoulder-derived fibroblast cell line cell
An immortal thoracic aorta-derived smooth muscle cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster thoracic aorta-derived smooth muscle cell line cell
An immortal abdominal cavity-derived fibroblast cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster abdominal cavity-derived fibroblast cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from cat.
immortal cat organism part-derived fibroblast cell line cell
disease: primary superficial spreading melanoma in vertical growth phase; from lung metastases in mice
disease: immortalized with SV40 large T antigen
disease: liver/pre-B lymphoblast hybridoma
disease: hereditary adenomatosis (Gardner's variant)
disease: somatic cell hybrid; Burkitt's lymphoma
disease: immortalized with SV40 early region
24IA subscript(2) E subscript(2) E subscript(10) D subscript(5)
24IA subscript(2) E subscript(2) E subscript(10) D subscript(5) cell
Human Embryonic Kidney 293
WEB: http://web.expasy.org/cellosaurus/CVCL_0045
WEB: https://www.atcc.org/Products/All/CRL-1573.aspx
BTO: BTO_0000007
EFO: EFO_0001182)
WEB: https://www.atcc.org/Products/All/CRL-10852.aspx#characteristics
disease: transformed with adenovirus 5 DNA
A 293-derived cell line that is stably transfected to secrete the chimeric protein (CHE-Fc), a recombinant soluble chirmeric protein useful as a probe to detect 9-O-Acetylated sialic acids.
WEB: http://web.expasy.org/cellosaurus/CVCL_6352
WEB: https://www.atcc.org/Products/All/CRL-2368.aspx
293/CHE-Fc was established by cotransfecting human embryonic 293 cell (ATCC CRL-1573) with the plasmid pCHE-Fc and a plasmid encoding Genetic (G418) resistance. The cell line is stably transfected to secrete the chimeric protein (CHE-Fc), a recombinant soluble chirmeric protein useful as a probe to detect 9-O-Acetylated sialic acids. CHE-Fc is a bifunctional molecule that can be used either to cleave acetyl groups at the ninth position of sialic acids or as a binding probe for 9-O-sialic acids. https://www.atcc.org/Products/All/CRL-2368.aspx
WEB: https://www.atcc.org/Products/All/CRL-11268.aspx
disease: amphotropic retroviral packaging line
3A-sub E [post crisis of 3A(tPA-30-1)] cell
disease: methylnitrosourea-induced lymphoma
7C subscript(2) C subscript(5) C subscript(12)
7C subscript(2) C subscript(5) C subscript(12) cell
disease: osteoblast; inducible adipocyte differentiation model
ATCC: CRL-7898,COSMIC ID:910921; ATCC CRL-7898
disease: malignant melanoma (skin primary)
WEB: http://bioinformatics.hsanmartino.it/hypercldb/cl199.html
WEB: http://www.atcc.org/products/all/CRL-1872
ATCC: COSMIC ID:910697; ATCC CRL-7905,CRL-7905
A9 cell (APRT and HPRT negative derivative of strain L)
disease: lymphoma; AMLV transformed lymphoblast
disease: Ehlers-Danlos syndrome, type II
disease: hybridoma fusion partner,T cell
anti-130-kDa Mesothelial-Ciliated Cells cell
disease: Ehlers-Danlos syndrome, presumed heterozygote
disease: nitrosoethylurea-induced neuroblastoma
disease: osteogenesis imperfecta (congenita)
Possible typographic error in 'Organism' field (value 'Antheraea perny') to be considered as 'Antheraea pernyi' (NCBI_Taxon: 7119) [SS]
disease: methylnitrosourea-induced smooth muscle-like tumor
disease: xeroderma pigmentosum, presumed heterozygote
disease: endothelioma; polyoma middle T antigen transformed
disease: Ehlers-Danlos syndrome, type I (autosomal dominant type)
WEB: http://capcelllines.ca/details.asp?id=132
Web: http://www.ncbi.nlm.nih.gov/pubmed/7535634
Possible typographic error in 'Organism' field (value 'insect - Estigmene agrea') to be considered as 'Estigmene agreai' (NCBI_Taxon: 56594) [SS]
disease: endothelial cell differentiation model; stem cell feeder layer
disease: cystic fibrosis; immortalized with Ad12-SV40 hybrid
disease: gliosarcoma; expresses beta-galactosidase
disease: adenocarcinoma; HPV-18 transfected
disease: clear cell carcinoma (kidney primary)
disease: epidermoid carcinoma (lung primary)
disease: unknown, probably lung anaplastic carcinoma
disease: carcinoma, epidermoid, from metastatic site
disease: keratinocyte; HPV-16 E6/E7 transformed
disease: connective tissue; osteosarcoma
disease: ductal adenocarcinoma; cystic fibrosis
DSMZ: ACC 360,COSMIC ID:910568; DSMZ ACC 360
disease: bronchogenic carcinoma (bronchus primary)
disease: expresses IgG1 (kappa) against IL-8
disease: galactosemia; galactose-1-phosphate uridyl transferase deficient
disease: promyeloblast; acute promyelocytic leukemia
Clone 1-5c-4 WKD of Chang Conjunctiva cell
disease: colorectal adenocarcinoma (colon primary)
LCL-1232
Derived from a melanoma of a 47 year old female.
CHEMBL: CHEMBL3308723
COLO-679
COLO679
DSMZ: ACC 264
EFO: EFO_0006372
LINCS_HMS: 50011
disease: T lymphocyte; transformed with REV-T; produces G-CSF
disease: T lymphocyte; transformed with REV-T: produces G-CSF
disease: produces a retrovirus containing the beta-galactosidase gene
disease: carcinoma; model for testing immunotherapy protocols in vivo
disease: expresses CTLA4Ig fusion protein
Possible typographic error in 'Organism' field (value 'Agrothis segetum') to be considered as 'Agrotis segetum' (NCBI_Taxon: 47767) [SS]
disease: acute T cell leukemia; CD4 negative
disease: medulloblastoma (cerebellum primary)
disease: osteogenesis imperfecta (tarda)
disease: Ehlers-Danlos syndrome, variant type
disease: desmoplastic cerebellar medulloblastoma
An immortal human B cell line cell originating from the blood of a male human with Burkitt lymphoma.
disease: carcinoma, bronchogenic large cell
Possible typographic error in 'Organism' field (value 'Drosophila, hydnei') to be considered as 'Drosophila hydnei' (NCBI_Taxon: 7224) [SS]
disease: carcinoma; small cell lung cancer
disease: carcinoma; small cell lung cancer (lung primary)
An immortal human B cell line cell originating from the pleural effusion of a Caucasian male with diffuse large B-cell lymphoma.
disease: lymphangiectasia (B lymphocyte primary); IL-6 dependent
disease: production of mouse c-myc protein
Possible typographic error in 'Organism' field (value 'insect - Estigmene agrea (saltmarsh catepillar)') to be considered as 'Estigmene agreai' (NCBI_Taxon: 56594) [SS]
Possible mapping of 'Organism' field (value 'orangutang') via synonym of 'Pongo pygmaeus' (NCBI_Taxon: 9600) [SS]
disease: Burkitts lymphoma (B lymphocyte primary)
disease: Ehlers-Danlos syndrome, type VII (arthrochalasia type)
immortal T cell line cell that is derived from blood T cells from mouse C57BL/6 inbred strain that has disease mouse lymphoma.
WEB: http://web.expasy.org/cellosaurus/CVCL_0255
disease: Ehlers-Danlos syndrome, possible heterozygote
disease: defective in single strand break repair
disease: lymphohematopoietic progenitor cell line\
disease: microvascular endothelial cell model
disease: microvascular endothelial cell model; expresses GFP
disease: embryonic carcinoma; testicular teratoma
disease: undifferentiated malignant glioma
disease: positive for FAK but null for p53, integrin signalling pathway
disease: Ehlers-Danlos syndrome, type II (hemorrhagic type)
disease: SV40 large T antigen transfected
disease: fibrous histiocytoma (primary unknown)
disease: monoblast; myelomonoblastic leukemia
disease: generates E1-deleted adenovirus vectors
disease: glomangioma; immortalized with hTERT
ANEUPLOID CHROMOSOME NUMBER - TRISOMY 8 ANEUPLOID CHROMOSOME NUMBER - TRISOMY
SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-NEGATIVE, DUE TO ADENOSINE DEAMINASE DEFICIENCY
GAUCHER DISEASE, TYPE I GLUCOSIDASE, ACID BETA; GBA
ADENOSINE DEAMINASE; ADA SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-NEGATIVE, DUE TO ADENOSINE DEAMINASE DEFICIENCY
SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-NEGATIVE, DUE TO ADENOSINE DEAMINASE DEFICIENCY ADENOSINE DEAMINASE; ADA
NPC1 GENE; NPC1 NIEMANN-PICK DISEASE, TYPE C1; NPC1
SPHINGOMYELIN PHOSPHODIESTERASE 1, ACID LYSOSOMAL; SMPD1 NIEMANN-PICK DISEASE, TYPE B
ACYL-COA DEHYDROGENASE, MEDIUM-CHAIN; ACADM ACYL-CoA DEHYDROGENASE, MEDIUM-CHAIN, DEFICIENCY OF
ACYL-CoA DEHYDROGENASE, LONG-CHAIN, DEFICIENCY OF
disease: ecotropic retroviral packaging line
A H25B10 cell that secretes greater amounts of immunoglobulin.
disease: carcinoma; small cell lung cancer; multidrug resistant
disease: ductal carcinoma (mammary gland primary)
immortal epithelial cell line cell that is derived from some breast epithelial cell from a human patient who had invasive ductal carcinoma.
WEB: http://web.expasy.org/cellosaurus/CVCL_1245
disease: primary acantholytic squamous cell carcinoma
immortal human epithelial cell line cell that was derived from some colon epithelial cell from a human patient with the disease colon carcinoma
WEB: http://web.expasy.org/cellosaurus/CVCL_0291
WEB: https://www.atcc.org/products/all/CCL-247.aspx
disease: ileocecal colorectal adenocarcinoma
an immortal human uterine cervix-derived epithelial cell line that was derived from cervical adenocarcinoma cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of her cancer on October 4, 1951.
WEB: http://www.atcc.org/products/all/CCL-2.aspx
WEB: https://www.ncbi.nlm.nih.gov/pubmed/12001993
disease: HeLa cells transfected with plasmid pSV2neoNR101
WEB: http://web.expasy.org/cellosaurus/CVCL_0027
WEB: https://en.wikipedia.org/wiki/Hep_G2
WEB: https://www.atcc.org/products/all/HB-8065.aspx
disease: hepatocellular carcinoma; transfected with a CYP7 minigene/luciferase construct
disease: produces human gamma interferon
An immortal human B cell line cell that derives from some B cell from a human blood sample.
disease: transfected; polytropic retroviral packaging cell line
disease: amelonotic melanoma (skin primary)
disease: dermatofibrosarcoma protuberans
disease: fibrosarcoma mixed (connective tissue primary)
disease: intestinal carcinoma (unknown primary)
disease: amelanotic melanoma (skin primary)
disease: adenocarcinoma (unknown primary)
disease: adenocar- cinoma (colon primary)
disease: adenocarcinoma (intestines or pancreas primary)
disease: gastric carcinoma (stomach primary
disease: malignant acanthocytosis; keratoacanthoma
disease: fibrosarcoma (connective tissue primary)
disease: fibrosarcoma (unknown primary)
disease: fibrosarcoma (unknown (unknown primary)
disease: stroma; HPV-16 E6/E7 transformed
disease: aspartoacylase deficiency; possible Canavan disease
disease: diffuse mixed lymphoma; B lymphoblast
ATCC: HTB-63,COSMIC ID:907067; ATCC HTB-63
disease: pigmented epithelium; immortalized with hTERT
WEB: https://www.atcc.org/Products/All/CRL-1730.aspx
disease: transfected; xenotropic retroviral packaging cell line
disease: antibody reactive with cell surface membranes of cancer cells
WEB: https://www.atcc.org/products/all/CCL-186.aspx
Possible mapping of 'Organism' field (value 'moth, cabbage') via synonym of 'Plutella xylostella' (NCBI_Taxon: 51655) [SS]
disease: PLC-gamma1 negative; model for T-cell receptor signaling
disease: transfected with PLC-gamma1 expression vector; control for J.?1 cells
immortal mouse monocyte cell line cell that derives from some monocyte immature dendritic cell from the bone marrow of mouse C57BL/6 inbred strain.
WEB: http://web.expasy.org/cellosaurus/CVCL_3727
WEB: https://www.atcc.org/Products/All/CRL-11904.aspx
an immortalized human T lymphocyte cell that was derived in the late 1970s from the peripheral blood of a 14-year-old boy with T cell leukemia
WEB: https://en.wikipedia.org/wiki/Jurkat_cells
An immortal human B cell line cell originating from the bone marrow of humans with chronic myeloid leukemia.
disease: chronic myelo- genous leukemia (bone marrow primary)
disease: acute myeloid leukemia, subtype M2
disease: gastric carcinoma (stomach primary)
Possible mapping of 'Organism' field (value 'bear, black') via synonym of 'Ursus americanus' (NCBI_Taxon: 9643) [SS]
disease: promyeloblast; acute lympho- blastic leukemia
disease: overproduces P element transposase
disease: Ehlers-Danlos syndrome, type VI (hemorrhagic type)
DSMZ: COSMIC ID:1161992; DSMZ ACC 673,ACC 673
disease: lacks GlcNAc glycosyl transferase function
disease: reduced transport of CMP-sialic acid into Golgi compartment
disease: reduced transport of UDP-galactose into Golgi compartment
immortal mouse fibroblast cell line cell that was derived from some fibroblasts from a C3H/An mouse connective tissue
WEB: http://web.expasy.org/cellosaurus/CVCL_4535
disease: glioblastoma; apoptosis studies; p53+, p16, p14ARF
disease: glioblastoma; p53 expression under tetracycline-induced promoter
disease: Ehlers-Danlos syndrome, type IV
disease: leukemia, acute megakaryoblastic
disease: expresses rat m1 muscarinic acetylcholine receptor
disease: expresses rat m3 muscarinic acetylcholine receptor
disease: carcinoma (mammary gland primary)
disease: SV40 large T antigen transfected; control for MmB19tsA. clone 2B2
disease: SV40 large T antigen transfected; Cre-lox recombination model
Possible mapping of 'Organism' field (value 'quail') via synonym of 'Odontophoridae' (NCBI_Taxon: 224313) [SS]
disease: undifferentiated lymphoma lymphoblast
disease: transfection host; exogenous gene expression
MCF-10A is a spontaneously immortalized, but nontransformed human mammary epithelial cell line cell that was derived from the breast tissue of a 36-year-old patient with fibrocystic changes
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12798140
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1975513
WEB: http://web.expasy.org/cellosaurus/CVCL_0598
WEB: https://www.atcc.org/products/all/CRL-10317.aspx
CVCL: CVCL_0598; EFO: EFO_0001200; ChEMBL: CHEMBL3307364; HMSL: HMSL50583
WEB: http://web.expasy.org/cellosaurus/CVCL_3633
WEB: http://web.expasy.org/cellosaurus/CVCL_3743
an immortal breast cancer cell line cell isolated in 1970 from a 69-year-old Caucasian woman.
WEB: http://web.expasy.org/cellosaurus/CVCL_0031
WEB: https://en.wikipedia.org/wiki/MCF-7
disease: adenocarcinoma (mammary gland primary)
disease: neuroepithelioma (brain primary)
disease: adenocarcinoma (prostate primary)
disease: luciferase resposive; androgen agonist/antagonist
an immortal breast cancer cell line cell derived from a human patient with breast adenocarcinoma
A model mammalian cell line cell that was genereated from the initial isolation in 1958 of epithelial cells from the kidney tubule of an adult Cocker Spaniel dog by Stewart H. Madin and Norman B. Darby, Jr..
disease: epidermoid carcinoma (cervix primary)
disease: megakaryoblast; chronic myelogenous leukemia
disease: virus-induced myeloid leukemia
disease: acute lympho- blastic leukemia
WEB: http://bioinformatics.hsanmartino.it/cldb/cl3535.html
An immortal mouse B cell line cell originating from mice with plasmacytoma.
disease: neutrophil progenitor cell line
disease: mesothelioma, biphasic (lung primary)
An immortal human B cell line cell originating from the blood of a female human with Burkitt lymphoma.
An immortal human B cell line cell originating from the bone marrow of humans with acute promyelocytic leukemia.
disease: carcinoma; classic small cell lung cancer (lung primary)
disease: large cell neuro- endocrine carcinoma (lung primary)
disease: squamous cell neuro- endocrine carcinoma (lung primary)
disease: papillary adenocar- cinoma (lung primary)
disease: carcinoma; classic small cell lung cancer
disease: large cell adenocarcinoma; non-small cell lung cancer
disease: squamous cell adenocarcinoma; non-small cell lung cancer
disease: neuroendocrine carc- cinoma; non-small cell lung cancer (lung primary)
disease: adenocarcinoma (lung primary)
disease: squamous cell carcinoma (lung primary)
disease: large cell carcinoma; poorly differentiated (lung primary)
disease: carcinoma; variant small cell lung cancer (lung primary)
disease: mesothelioma (pleura primary)
disease: small cell lung cancer; adenocar- cinoma; squamous cell carcinoma
disease: non-small cell lung cancer (lung primary)
disease: carcinoma; non-small cell lung cancer
disease: squamous cell carcinoma; mesothelioma (lung primary)
disease: small cell lung cancer; adeno- carcinoma; squamous cell carcinoma
disease: mucoepidermoid pulmonary carcinoma
disease: cortex adrenocortical carcinoma
disease: alveolus); bronchioalveolar carcinoma; non-small cell lung cancer
disease: papillary adeno- carcinoma (lung primary)
disease: large cell carci- noma (lung primary)
disease: carcinoma; small cell lung cancer (unknown primary)
disease: mixed adeno- squamous and carcinoma (lung primary)
disease: extrapulmonary small cell carcinoma (prostate primary)
disease: carcinoma; large cell lung cancer (lung primary)
disease: large cell; neuroendocrine; carcinoma; non-small cell lung cancer
disease: papillary adenocarci- noma (lung primary)
disease: adenocarcinoma; non-small cell lung cancer (lung primary)
disease: neuroblastoma x root ganglion neuron hybrid
disease: glial cell; neuron; glioblastoma; neuro- blastoma (hybrid)
disease: adenoma; carboxypeptidase E defective
disease: IL-2 dependent, cytotoxic to a wide range of malignant cells
disease: IL-2 independent, cytotoxic to a wide range of malignant cells
disease: immortalized with SV40 large T plasmid, p129
disease: carcinoma, embryonal pluripotent
WEB: http://web.expasy.org/cellosaurus/CVCL_3407
WEB: https://www.atcc.org/Products/All/CRL-1973.aspx
The parental NTERA-2 lines was established in 1980 from a nude mouse xenograft of the Tera-2 cell line (see ATCC HTB-106). The NTERA-2 cl.D1 cell line is a pluripotent human testicular embryonal carcinoma cell line derived by cloning the NTERA-2 cell line. Ref: https://www.atcc.org/Products/All/CRL-1973.aspx#characteristics
epithelial-like,differentiation changes phenotype. https://www.atcc.org/Products/All/CRL-1973.aspx
disease: cystoadenocarcinoma, low differentiated, papillary serous; G2/3 FIGO stage III c
disease: cystoadenocarcinoma, high grade papillary serous; G3 FIGO stage III c
disease: adenocarcinoma, low differentiated; G3 FIGO stage IV (pleural metastasis)
disease: Ehlers-Danlos syndrome, type III
disease: malignant papillary serous adenocarcinoma (ovary primary)
disease: ZAP-70 negative; model for T cell receptor signaling
disease: transfected with ZAP-70 expression vector; control for P116 cells
disease: teratocarcinoma; embryonic carcinoma
A subclone of the parental line CCL-46, selected for its high production of Interleukin-1 (IL-1).
disease: Burkitts lymphoma; B lymphoblast
immortal mouse mast cell line cell that was derived from some lymph node mast cell from a /2 mouse with mast cell neoplasm
WEB: http://www.ncbi.nlm.nih.gov/pubmed/18432777
disease: teratocarcinoma (ovary primary)
PA317 cell line containing JR-gal cell
disease: produces a retrovirus containing the human cyclin E-L gene
disease: produces a retrovirus containing the human cyclin E-S gene
disease: produces amphotropic control retrovirus; G418 resistant
WEB: https://www.atcc.org/Products/All/CRL-1469.aspx
an immortal human prostate epithelium-derived cell line cell that was established in 1979 from bone metastasis of grade IV of prostate cancer in a 62-year-old Caucasian male.
disease: diffuse large cell non-Hodgkins lymphoma (B lymphocyte primary)
disease: embryonic carcinoma; HAT resistant
disease: malignant primitive neuroectodermal tumor
disease: produces an infectious retrovirus with a neomycin resistance gene
disease: galactosyltransferase I deficient
disease: heparin sulfate N-sulfotransferase deficient
Possible typographic error in 'Organism' field (value 'racoon') to be considered as 'raccoon'. Possible mapping of 'raccoon' via synonym of 'Procyon lotor' (NCBI_Taxon: 9654) [SS]
disease: ductal adenocarcinoma; same patient as Panc 10.05 cells
disease: xenotropic retroviral packaging line
disease: immortalized with Ad12-SV40 hybrid virus
disease: chemically induced fibrosarcoma
disease: produces a retrovirus containing the vHa-ras oncogene
disease: brain, undifferentiated malignant glioma
disease: insulinoma; produces somatostatin and L-dopa-decarboxylase but not insulin
disease: insulinoma; produces insulin and L-dopa-decarboxylase but not somatostatin
disease: insulinoma; produces insulin and somatostatin
disease: carcinoma; control for RKO-E6 and RKO-AS45-1 cells
disease: carcinoma; apoptosis model; overexpression of GADD45
disease: carcinoma; apoptosis model; negligible p53 expression
disease: non-Hodgkins lymphoma; B lymphoblast
ATCC: CRL-1671,COSMIC ID:930082; ATCC CRL-1671
disease: 7, 12-dimethylbenz(a)anthracene- induced tumor
disease: xeroderma pigmentosum; presumed heterozygote
disease: squamous cell carcinoma (nasal septum primary)
disease: Hodgkins disease; Cell types: EBV + B-lymphoblastoid cell line
An immortal human B cell line cell originating from humans with multiple myeloma.
disease: transfected with HPV-18 and Ki-MSV
disease: dibenzanthracene-induced malignant fibrosarcoma
disease: dibenzanthracene-induced fibrosarcoma
disease: pseudoachondroplasia (autosomal dominant)
disease: carcinoma; small cell lung cancer; large cell variant
SIRC (Statens Se- ruminstitut Rabbit Cornea)
SIRC (Statens Se- ruminstitut Rabbit Cornea) cell
disease: rhabdomyosarcoma (muscle primary)
ATCC: HTB-88,COSMIC ID:909720; ATCC HTB-88
WEB: http://www.atcc.org/products/all/HTB-68.aspx
ATCC: COSMIC ID:909725; ATCC HTB-71,HTB-71
AU-Mel
P36
SK MEL 28
SK Mel 28
SK-MEL 28
SK-MEL28
SK-Mel28
SK.MEL.28
SKMEL-28
SKML-28
SKMel-28
SKMel28
SKmel28
ChEMBL: CHEMBL3308494
A melanoma cell line cell. This cell line was established in 1974 from a metastatic site (axillary lymph node) in a 24-year-old Caucasian female with malignant melanoma, expresses mutant B-Raf (V600E) and wildtype N-Ras.
WEB: http://web.expasy.org/cellosaurus/CVCL_1706
WEB: http://www.ncbi.nlm.nih.gov/pubmed/3121170
WEB: https://strap.nci.nih.gov/celline_detail.php?sample_id=56
SK MES 1
SK-MES
disease: embryonal neuro- blastoma (brain/neuroblast primary)
disease: retroperitoneal; malignant; primitive neuroectodermal tumor
disease: mesodermal tumor (mixed); consistent with leiomyosarcoma
disease: Steel factor deficient; SV40 large T immortalized
disease: pleomorphic hepatocellular carcinoma
disease: transformed with adenovirus 5 DNA; packaging cell line
disease: large cell immuno- blastic lymphoma (unknown primary)
disease: immortalized with SV40 large T antigen; deficient for Yes and Fyn
disease: ductal carcinoma (pancreas primary)
an immortal human B cell line cell that is derived from a 8-year-old Caucasian male human patient with an acute lymphoblastic leukemia.
WEB: http://www.atcc.org/products/all/CRL-1929.aspx
WEB: http://www.atcc.org/~/ps/CRL-1929.ashx
immortal human T cell line cell that was derived from some human T cell from a patient who had disease T-cell childhood lymphoblastic lymphoma
WEB: https://www.atcc.org/products/all/CRL-1942.aspx
disease: angiomyolipoma; immortalized with SV40 large T antigen and human telomerase
disease: immortalized with SV40 large T antigen; deficient for Src,Yes, and Fyn
an immortal human B cell line cell that was derived some B cell isolated from human blood
WEB: https://www.atcc.org/products/all/CRL-1992.aspx
LCL-1486
T47D cell
WEB: https://www.atcc.org/products/all/HTB-133.aspx
ECACC: 85102201
disease: colorectal carcinoma (colon primary)
Possible mapping of 'Organism' field (value 'toad, tropical') via synonym of 'Bufo' (NCBI_Taxon: 8383) [SS]
disease: HPV-16 E6/E7 and c-Ha-ras cotransformed
disease: model for cytokine (IL-3) signaling pathways and myeloid progenitor cell differentiation
disease: immortalized with SV40 T antigen
disease: lymphoma; Hodgkins disease (lymph node primary)
disease: diffuse large cell lymphoma, non-Hodgkins
disease: primary malignant adenocarcinoma; endometrioid carcinoma
disease: primary malignant adenocarcinoma; clear cell carcinoma
disease: cutaneous; heterozygous for tuberin; tuberous sclerosis model
ATCC: COSMIC ID:930299; ATCC CRL-1803,CRL-1803
disease: osteogenesis imperfecta (severe congenita)
disease: histiocytic lymphoma; neomycin resistant
WEB: https://www.atcc.org/Products/All/HTB-96.aspx
immortal human B cell line cell that was derived from some human B cell isolated from a patient with multiple myeloma
An immortal human tonsil-derived B cell line cell originating from the tonsil of humans with non-Hodgkin lymphoma.
Contaminated/misidentified. This cell line is not the original glioblastoma cell line established in 1968 at the University of Uppsala. As described in PubMed=27582061 it is most probably also a glioblastoma cell line but whose origin is unknow. See U-87MG Uppsala (CVCL_GP63) for the original U-87MG cell line. See more: http://web.expasy.org/cellosaurus/CVCL_0022.
a immortal human monocyte cell line cell that was derived from the histiocytic lymphoma of a 37-year-old male patient
WEB: https://en.wikipedia.org/wiki/U937_cell
disease: defective in nucleotide excision repair
disease: carcinoma, epithelioid (bone primary)
disease: papilloma virus-induced carcinoma
disease: stroma; assay system for hBMP-2
Possible mapping of 'Organism' field (value 'woodchuck, Eastern') via synonym of 'Marmota monax' (NCBI_Taxon: 9995) [SS]
disease: methylcholanthrene-induced fibrosarcoma
disease: MoMuLV retroviral packaging line
disease: primary superficial spreading melanoma in radial growth phase/vertical growth phase
disease: nodular melanoma in vertical growth phase
disease: primary melanoma in vertical growth phase
disease: primary superficial spreading melanoma in vertical growth phase
disease: adenovirus 12-SV40 hybrid transformed
disease: Rous sarcoma virus-induced tumor
Possible mapping of 'Organism' field (value 'toad, South African') via synonym of 'Bufonidae' (NCBI_Taxon: 8382) [SS]
disease: immortalized with adenovirus12-SV40 virus hybrid
disease: ductal carcinoma (mammary gland epithelium primary)
disease: produces a retrovirus containing the adenovirus 12S E1A gene
disease: produces a retrovirus containing the adenovirus 13S E1A gene
disease: produces a retrovirus containing human alkaline phosphatase gene
An immortal pulmonary nerve plexus-derived cell line cell that derives from cattle.
immortal cattle pulmonary nerve plexus-derived cell line cell
An immortal pelvic fin-derived cell line cell that derives from human.
immortal human pelvic fin-derived cell line cell
An immortal round window-derived cell line cell that derives from human.
immortal human round window-derived cell line cell
An immortal bipolar neuron cell line cell that derives from human.
immortal human bipolar neuron cell line cell
An immortal right ureter-derived cell line cell that derives from human.
immortal human right ureter-derived cell line cell
An immortal larva-derived cell line cell that derives from forest day mosquito.
immortal forest day mosquito larva-derived cell line cell
An immortal rectum-derived cell line cell that derives from mouse.
immortal mouse rectum-derived cell line cell
An immortal endometrium-derived cell line cell that derives from rat.
immortal rat endometrium-derived cell line cell
An immortal multi-cellular organism-derived cell line cell that derives from chicken.
immortal chicken multi-cellular organism-derived cell line cell
An immortal peripheral neuron cell line cell that derives from rat.
immortal rat peripheral neuron cell line cell
An immortal superior rostral sulcus-derived cell line cell that derives from rat.
immortal rat superior rostral sulcus-derived cell line cell
An immortal muscle cell line cell that derives from rat.
An immortal skeletal muscle cell line cell that derives from rat.
immortal rat skeletal muscle cell line cell
An immortal myoblast cell line cell that derives from rat.
An immortal thymus-derived cell line cell that derives from cattle.
immortal cattle thymus-derived cell line cell
An immortal connective tissue-derived cell line cell that derives from rat.
immortal rat connective tissue-derived cell line cell
An immortal follicular fluid-derived cell line cell that derives from mouse.
immortal mouse follicular fluid-derived cell line cell
An immortal late embryo-derived cell line cell that derives from rat.
immortal rat late embryo-derived cell line cell
An immortal mammary gland-derived cell line cell that derives from rat.
immortal rat mammary gland-derived cell line cell
An immortal fetal membrane-derived cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit fetal membrane-derived cell line cell
An immortal aorta-derived cell line cell that derives from Ovis.
immortal Ovis aorta-derived cell line cell
An immortal peripheral neuron cell line cell that derives from pig.
immortal pig peripheral neuron cell line cell
An immortal blood cell line cell that derives from pig.
An immortal dento-alveolar joint-derived cell line cell that derives from rainbow trout.
immortal rainbow trout dento-alveolar joint-derived cell line cell
An immortal gill-derived cell line cell that derives from rainbow trout.
immortal rainbow trout gill-derived cell line cell
An immortal gonad-derived cell line cell that derives from rainbow trout.
immortal rainbow trout gonad-derived cell line cell
An immortal female gonad-derived cell line cell that derives from rainbow trout.
immortal rainbow trout female gonad-derived cell line cell
An immortal cornea structure-derived fibroblast cell line cell that derives from human.
immortal human cornea structure-derived fibroblast cell line cell
An immortal glial cell line cell that derives from rat.
An immortal prepuce of penis-derived cell line cell that derives from rhesus macaque.
immortal rhesus macaque prepuce of penis-derived cell line cell
An immortal endothelial cell line cell that derives from rat.
An immortal liver-derived cell line cell that derives from chicken.
immortal chicken liver-derived cell line cell
An immortal epithelial cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster epithelial cell line cell
An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from Cottontail rabbit.
immortal Cottontail rabbit mixed endoderm/mesoderm-derived structure-derived cell line cell
An immortal cell line cell that derives from fall armyworm.
An immortal female gonad-derived cell line cell that derives from fall armyworm.
immortal fall armyworm female gonad-derived cell line cell
An immortal glomerular capsule-derived cell line cell that derives from rat.
immortal rat glomerular capsule-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from guinea pig.
immortal guinea pig pair of lungs-derived cell line cell
An immortal septum of telencephalon-derived cell line cell that derives from sheep.
immortal sheep septum of telencephalon-derived cell line cell
An immortal kidney-derived cell line cell that derives from Dasyuridae.
immortal Dasyuridae kidney-derived cell line cell
An immortal nasal vestibule-derived cell line cell that derives from rat.
immortal rat nasal vestibule-derived cell line cell
An immortal epidermal cell line cell that derives from hagfish.
immortal hagfish epidermal cell line cell
An immortal endothelial cell line cell that derives from mouse.
immortal mouse endothelial cell line cell
An immortal spherical lensed eye-derived cell line cell that derives from mouse.
immortal mouse spherical lensed eye-derived cell line cell
An immortal cell line cell that derives from European rabbit, rabbit.
immortal European rabbit, rabbit cell line cell
An immortal adrenal cortex-derived cell line cell that derives from human.
immortal human adrenal cortex-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from Canis.
immortal Canis lung-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from American black bear.
immortal American black bear lung-derived cell line cell
An immortal myeloblast cell line cell that derives from human.
immortal human myeloblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from white-handed gibbon.
immortal white-handed gibbon skin-derived fibroblast cell line cell
An immortal lung-derived fibroblast cell line cell that derives from Chinese hamster.
immortal Chinese hamster lung-derived fibroblast cell line cell
An immortal 16914-derived fibroblast cell line cell that derives from human.
immortal human 16914-derived fibroblast cell line cell
An immortal organism part-derived fibroblast cell line cell that derives from Syrian golden hamster.
immortal Syrian golden hamster organism part-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from Geoffroy's marmoset.
immortal Geoffroy's marmoset peripheral vein-derived B cell line cell
An immortal peripheral vein-derived B cell line cell that derives from White-cheeked Gibbon.
immortal White-cheeked Gibbon peripheral vein-derived B cell line cell
An immortal thorax-derived fibroblast cell line cell that derives from northern lesser bushbaby.
immortal northern lesser bushbaby thorax-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from Azara's night monkey.
immortal Azara's night monkey skin-derived fibroblast cell line cell
An immortal skin-derived fibroblast cell line cell that derives from De Brazza's monkey.
immortal De Brazza's monkey skin-derived fibroblast cell line cell
An immortal peripheral vein-derived B cell line cell that derives from vervet monkey.
immortal vervet monkey peripheral vein-derived B cell line cell
An immortal organism part-derived epithelial cell line cell that derives from human.
immortal human organism part-derived epithelial cell line cell
An immortal axilla-derived fibroblast cell line cell that derives from human.
immortal human axilla-derived fibroblast cell line cell
An immortal arm-derived fibroblast cell line cell that derives from patas monkey.
immortal patas monkey arm-derived fibroblast cell line cell
An immortal pulmonary artery-derived endothelial cell line cell that derives from cattle.
immortal cattle pulmonary artery-derived endothelial cell line cell
An immortal pulmonary artery-derived smooth muscle cell line cell that derives from cattle.
immortal cattle pulmonary artery-derived smooth muscle cell line cell
An immortal retina structure-derived epithelial cell line cell that derives from human.
immortal human retina structure-derived epithelial cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from Red-bellied titi.
immortal Red-bellied titi thigh-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from patas monkey.
immortal patas monkey thigh-derived fibroblast cell line cell
An immortal calf-derived fibroblast cell line cell that derives from human.
immortal human calf-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from brown woolly monkey.
immortal brown woolly monkey thigh-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from red-chested mustached tamarin.
immortal red-chested mustached tamarin thigh-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from South American squirrel monkey.
immortal South American squirrel monkey thigh-derived fibroblast cell line cell
An immortal thigh-derived fibroblast cell line cell that derives from saddlebacked tamarin.
immortal saddlebacked tamarin thigh-derived fibroblast cell line cell
An immortal nose structure-derived fibroblast cell line cell that derives from human.
immortal human nose structure-derived fibroblast cell line cell
An immortal carotid artery-derived smooth muscle cell line cell that derives from cattle.
immortal cattle carotid artery-derived smooth muscle cell line cell
An immortal brain-derived fibroblast cell line cell that derives from human.
immortal human brain-derived fibroblast cell line cell
An immortal eye structure-derived epithelial cell line cell that derives from pig.
immortal pig eye structure-derived epithelial cell line cell
An immortal eye structure-derived epithelial cell line cell that derives from mouse.
immortal mouse eye structure-derived epithelial cell line cell
An immortal mammary gland-derived cell line cell that derives from human.
immortal human mammary gland-derived cell line cell
An immortal pair of lungs-derived cell line cell that derives from Mustelinae (i.e. mink).
immortal mink cell line cell
An immortal cell line cell that derives from Oryzias latipes (i.e., medaka).
immortal medaka cell line cell
a biological process that presents the survival of a microbe inside a cell line cell.
microbial survival inside cell line cell
a microbial survival inside cell line cell where the microbe is a bacterium
bacterial survival inside cell line cell
a biological process that specifies the interaction between cell line cell and a pathogen
cell line cell-pathogen interaction
a biological process that specifies the interaction between cell line cell and a vaccine
cell line cell-vaccine interaction
an gene expression that occurs in a cell line cell.
cell line cell gene expression
A cell line that is expected to be capable of indefinite propagation in an vitro culture.
OBI-CLO Alignment Working Group (Spring 2013)
immortal cell line
A cell line is able to support only a limited number of passages in vitro.
A mortal cell line is not capable of supporting indefinite propagation in vitro, being limited by entry of its cells into senescence.
mortal cell line
We recommend against use of this term, as 'primary' is used also to refer to cultured cell populaitons that have yet to be passaged.
A human glioblastoma cell line cell. The cell line is part of the NCI-60 screening panel.
A clonal HeLa cell line cell that stably expresses the FRET-based initiator caspase reporter (ICRP).
WEB: http://web.expasy.org/cellosaurus/CVCL_9T98
WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461398/
METHYL-CPG-BINDING PROTEIN 2; MECP2 RETT SYNDROME; RTT
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
HOLOPROSENCEPHALY TRANSLOCATED CHROMOSOME
RETT SYNDROME; RTT METHYL-CPG-BINDING PROTEIN 2; MECP2
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE I; MODY1
3-@HYDROXY-3-METHYLGLUTARYL-COENZYME A LYASE DEFICIENCY
HEPATOCYTE NUCLEAR FACTOR 4-ALPHA; HNF4A MATURITY-ONSET DIABETES OF THE YOUNG, TYPE I; MODY1
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE I; MODY1 HEPATOCYTE NUCLEAR FACTOR 4-ALPHA; HNF4A
HLA HISTOCOMPATIBILITY TYPE: 142800 THROUGH 142860 & 142880
RENAL HAMARTOMAS, NEPHROBLASTOMATOSIS, AND FETAL GIGANTISM
NIJMEGEN BREAKAGE SYNDROME NIJMEGEN BREAKAGE SYNDROME GENE; NBS1
SPHEROCYTOSIS, HEREDITARY; HS CHROMOSOME DELETION
ANEUPLOID CHROMOSOME NUMBER - TRISOMY 9 ANEUPLOID CHROMOSOME NUMBER - TRISOMY
FANCONI ANEMIA COMPLEMENTATION GROUP UNDETERMINED
ADDITIONAL HUMAN/MOUSE SOMATIC CELL HYBRIDS
MAJOR AFFECTIVE DISORDER - 125480 OR 309200
CIRRHOSIS, FAMILIAL CIRRHOSIS, FAMILIAL, WITH PULMONARY HYPERTENSION, INCLUDED
BIOTINIDASE; BTD MULTIPLE CARBOXYLASE DEFICIENCY, LATE-ONSET, INCLUDED
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP D; XPD EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 2; ERCC2
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR CYSTIC FIBROSIS; CF
APPARENTLY HEALTHY NON-FETAL TISSUE MAJOR AFFECTIVE DISORDER - 125480 OR 309200
CYSTIC FIBROSIS; CF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR
ACYL-CoA DEHYDROGENASE, MEDIUM-CHAIN, DEFICIENCY OF ACYL-COA DEHYDROGENASE, MEDIUM-CHAIN; ACADM
MONOZYGOTIC TWIN PAIRS CYSTIC FIBROSIS; CF
ESTERASE D; ESD S-FORMYLGLUTATHIONE HYDROLASE, INCLUDED; FGH, INCLUDED CHROMOSOME DELETION
FRAGILE SITE MENTAL RETARDATION 1; FMR1 MONOZYGOTIC TWIN PAIRS
MONOZYGOTIC TWIN PAIRS FRAGILE SITE MENTAL RETARDATION 1; FMR1
MONOZYGOTIC TWIN PAIRS CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR CYSTIC FIBROSIS; CF
ACHONDROGENESIS; TYPE 1 - 200600; TYPE 2 - 200610; OR GREBE TYPE - 200700
APPARENTLY HEALTHY NON-FETAL TISSUE TRANSLOCATED CHROMOSOME
ADENOSINE DEAMINASE DEFICIENCY WITH NO IMMUNODEFICIENCY CHROMOSOME DELETION
VELOCARDIOFACIAL SYNDROME CHROMOSOME DELETION
MAJOR AFFECTIVE DISORDER - 125480 OR 309200 APPARENTLY HEALTHY NON-FETAL TISSUE
DYSTROPHIN; DMD MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD CHRONIC GRANULOMATOUS DISEASE (XK-RELATED; CGD) - 306400 OR 314850 CHROMOSOME DELETION
GLUCOSIDASE, ACID BETA; GBA GAUCHER DISEASE, TYPE I
HYPOPHOSPHATASIA; PHOSPHOETHANOLAMINURIA - 241500 OR 241510
IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME
BURKITT LYMPHOMA; BL TRANSLOCATED CHROMOSOME
MULTIPLE ENDOCRINE NEOPLASIA, TYPE II; MEN2
FIBROBLAST GROWTH FACTOR RECEPTOR 3; FGFR3 THANATOPHORIC DYSPLASIA; TD
ADENOSINE DEAMINASE DEFICIENCY WITH NO IMMUNODEFICIENCY
CEROID LIPOFUSCINOSIS, NEURONAL 3, JUVENILE; CLN3
ADRENAL HYPOPLASIA WITH ADDITIONAL CONGENITAL MALFORMATIONS
RETINOBLASTOMA; RB1 OSTEOSARCOMA, RETINOBLASTOMA-RELATED, INCLUDED
WILMS TUMOR 1; WT1 APPARENTLY HEALTHY NON-FETAL TISSUE
OSTEOGENESIS IMPERFECTA: AUTOSOMAL DOMINANT- 166200,166210,166220, OR 166230
GAUCHER DISEASE, TYPE II GLUCOSIDASE, ACID BETA; GBA
PEROXISOME BIOGENESIS FACTOR 26; PEX26 REFSUM DISEASE, INFANTILE FORM
DNA METHYLTRANSFERASE 3B; DNMT3B APPARENTLY HEALTHY NON-FETAL TISSUE IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME
IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME APPARENTLY HEALTHY NON-FETAL TISSUE
IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME DNA METHYLTRANSFERASE 3B; DNMT3B
GLUCOSIDASE, ACID BETA; GBA GAUCHER DISEASE, TYPE II
ATAXIA-TELANGIECTASIA MUTATED GENE; ATM ATAXIA-TELANGIECTASIA; AT
5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR HEMOPHILIA B; HEMB
NEUROPATHY, CONGENITAL SENSORY, WITH ANHIDROSIS
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP F; XPF
RECQ PROTEIN-LIKE 3; RECQL3 BLOOM SYNDROME; BLM
ISOCHROMOSOME ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
ATAXIA-TELANGIECTASIA; AT ATAXIA-TELANGIECTASIA MUTATED GENE; ATM
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2) CYSTIC FIBROSIS; CF
An immortal human peripheral vein-derived B cell line cell originating from the blood of humans and tranformed with Epstein-Barr virus (EBV).
CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME DELETION PRADER-WILLI SYNDROME; PWS
PRADER-WILLI SYNDROME; PWS CHROMOSOME DELETION
CHROMOSOME 6 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE X CHROMOSOME SOMATIC CELL HYBRIDS
MILLER-DIEKER LISSENCEPHALY SYNDROME; MDLS CHROMOSOME DELETION
CRIGLER-NAJJAR SYNDROME UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1
ORNITHINE TRANSCARBAMYLASE DEFICIENCY, HYPERAMMONEMIA DUE TO; OTC
EPILEPSY, PROGRESSIVE MYOCLONIC 2; EPM2A
NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
RETINITIS PIGMENTOSA 1; RP1 RETINITIS PIGMENTOSA 1 GENE; RP1
RETINITIS PIGMENTOSA 1 GENE; RP1 RETINITIS PIGMENTOSA 1; RP1
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3
INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3
THANATOPHORIC DYSPLASIA; TD FIBROBLAST GROWTH FACTOR RECEPTOR 3; FGFR3
ALZHEIMER DISEASE; AD APOLIPOPROTEIN E; APOE
APOLIPOPROTEIN E; APOE ALZHEIMER DISEASE; AD
NDPT081 ISCHEMIC STROKE DNA PANEL ISCHEMIC STROKE
PARKINSON'S DISEASE LATE ONSET PARKINSON'S DNA PANEL, AFFECTED INDIVIDUALS
POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS PARKINSON'S DISEASE ESSENTIAL TREMOR-MOVEMENT DISORDER
POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
EPIDERMOLYSIS BULLOSA: DYSTROPHIC, JUNCTIONAL, OR SIMPLEX TYPES
PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S DISEASE; AFFECTED INDIVIDUALS
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL POPULATION/CONVENIENCE CONTROL
ISCHEMIC STROKE NDPT081 ISCHEMIC STROKE DNA PANEL
PELIZAEUS-MERZBACHER DISEASE; PMD APPARENTLY HEALTHY NON-FETAL TISSUE
PROTEOLIPID PROTEIN 1; PLP1 PELIZAEUS-MERZBACHER DISEASE; PMD
MENTAL RETARDATION, X-LINKED NONSPECIFIC, TYPE 1; MRX1
GIANT CELL HEPATITIS, NEONATAL IDIOPATHIC NEONATAL HEMOCHROMATOSIS, INCLUDED
APPARENTLY HEALTHY NON-FETAL TISSUE NEUROFIBROMATOSIS, TYPE I; NF1
USH1C GENE; USH1C USHER SYNDROME, TYPE IC; USH1C
USHER SYNDROME, TYPE IC; USH1C USH1C GENE; USH1C
RECQ PROTEIN-LIKE 4; RECQL4 ROTHMUND-THOMSON SYNDROME; RTS
ROTHMUND-THOMSON SYNDROME; RTS RECQ PROTEIN-LIKE 4; RECQL4
WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED LAMIN A/C; LMNA
TRISOMY 21 NIA AGING CELL REPOSITORY DNA PANEL - DOWN SYNDROME
TRISOMY 21 ANEUPLOID CHROMOSOME NUMBER - TRISOMY
NIA AGING CELL REPOSITORY DNA PANEL - DOWN SYNDROME TRISOMY 21
RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 1; RCDP1
CLN2 GENE; CLN2 CEROID LIPOFUSCINOSIS, NEURONAL 2, LATE INFANTILE TYPE; CLN2
INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP GLUCOSIDASE, ACID BETA; GBA HEXOSAMINIDASE A; HEXA NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC XYY SYNDROME
OSTEOGENESIS IMPERFECTA: GENETICS UNCERTAIN; LETHAL
OSTEOGENESIS IMPERFECTA: GENETICS UNCERTAIN; LETHAL INVERTED CHROMOSOME
APPARENTLY HEALTHY NON-FETAL TISSUE MENKES SYNDROME
APPARENTLY HEALTHY NON-FETAL TISSUE VON HIPPEL-LINDAU SYNDROME; VHL
CARBOXYPEPTIDASE N, POLYPEPTIDE 1, 50-KD; CPN1 CARBOXYPEPTIDASE N DEFICIENCY
XERODERMA PIGMENTOSUM: COMPLEMENTATION GROUP UNDETERMINED
CHROMOSOME 6 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
HUMAN VARIATION PANEL - AFRICANS NORTH OF THE SAHARA
HUMAN VARIATION PANEL - PACIFIC SNP500 PANEL
CHROMOSOME 6 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 6 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 7 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
POPULATION/CONVENIENCE CONTROL CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS POPULATION/CONVENIENCE CONTROL
ZELLWEGER SYNDROME; ZS PEROXISOME BIOGENESIS FACTOR 26; PEX26
OSTEOGENESIS IMPERFECTA, TYPE IV; OI4 COLLAGEN, TYPE I, ALPHA-2; COL1A2
REFSUM DISEASE, INFANTILE FORM RETINITIS PIGMENTOSA 1; RP1
CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS SPOUSAL CONTROL CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS POPULATION/CONVENIENCE CONTROL
SNP500 PANEL HUMAN VARIATION PANEL - PACIFIC
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C; XPC
COLLAGEN, TYPE I, ALPHA-2; COL1A2 OSTEOGENESIS IMPERFECTA, TYPE IV; OI4
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
PARKINSON'S DISEASE PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
GALACTOSEMIA GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; GALT
CHROMOSOME 7 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 22 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 22 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS
SPOUSAL CONTROL DNA CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 2; ERCC2 TRICHOTHIODYSTROPHY; TTD ICHTHYOSIFORM ERYTHRODERMA WITH HAIR ABNORMALITY AND MENTAL AND GROWTH RETARDATION, INCLUDED XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP D; XPD
CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS SPOUSAL CONTROL
LATE ONSET PARKINSON'S DNA PANEL, AFFECTED INDIVIDUALS PARKINSON'S DISEASE
PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES PARKINSON'S DISEASE
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
CHROMOSOME 12 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 22 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; GREATER THAN 7 YEARS SURVIVAL ALS PANEL CAUCASIAN FROM THE US
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
POPULATION/CONVENIENCE CONTROL NDPT031- AFRICAN AMERICAN CONTROL PANEL
NDPT031- AFRICAN AMERICAN CONTROL PANEL POPULATION/CONVENIENCE CONTROL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL POPULATION/CONVENIENCE CONTROL
POPULATION/CONVENIENCE CONTROL CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 POPULATION/CONVENIENCE CONTROL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 POPULATION/CONVENIENCE CONTROL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S DNA PANEL; AFFECTED INDIVIDUALS
DNA CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS SPOUSAL CONTROL
YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS PARKINSON'S DISEASE
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE US
YOUNG ONSET PARKINSON'S DNA PANEL; AFFECTED INDIVIDUALS PARKINSON'S DISEASE
CHROMOSOME 9 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
SPINOCEREBELLAR ATAXIA 1; SCA1 ATAXIN 1; ATX1
GLUCOKINASE; GCK MATURITY ONSET DIABETES OF THE YOUNG, TYPE II; MODY2
ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 9 SOMATIC CELL HYBRIDS
SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE N; SNRPN PRADER-WILLI SYNDROME; PWS
NEMALINE MYOPATHY 2, AUTOSOMAL RECESSIVE; NEM2 CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC 1; PFIC1
POPULATION/CONVENIENCE CONTROL CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
DNA CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS POPULATION/CONVENIENCE CONTROL
ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS
FANCONI ANEMIA, COMPLEMENTATION GROUP A; FANCA
HEXOSAMINIDASE A; HEXA TAY-SACHS DISEASE; TSD
COCKAYNE SYNDROME TYPE I - 216400 OR TYPE III - 216411
COLLAGEN, TYPE I, ALPHA-2; COL1A2 OSTEOGENESIS IMPERFECTA: GENETICS UNCERTAIN; LETHAL
ANEUPLOID CHROMOSOME NUMBER - TRISOMY 13 ANEUPLOID CHROMOSOME NUMBER - TRISOMY
DIABETES MELLITUS, JUVENILE-ONSET INSULIN-DEPENDENT; IDDM
TRANSLOCATED CHROMOSOME DIGEORGE SYNDROME; DGS
TELANGIECTASIA, HEREDITARY HEMORRHAGIC, OF RENDU, OSLER, AND WEBER; HHT
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G; XPG
ADENOSINE DEAMINASE DEFICIENCY WITH NO IMMUNODEFICIENCY ADENOSINE DEAMINASE; ADA
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP A; XPA
PROCOLLAGEN-LYSINE, 2-OXOGLUTARATE 5-DIOXYGENASE; PLOD1 EHLERS-DANLOS SYNDROME, TYPE VI
CHROMOSOME 8 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
PELIZAEUS-MERZBACHER DISEASE; PMD PROTEOLIPID PROTEIN 1; PLP1
HYPERGLYCINEMIA, ISOLATED NONKETOTIC, TYPE I
SHPRINTZEN-GOLDBERG CRANIOSYNOSTOSIS SYNDROME
CYSTINOSIS, NEPHROPATHIC; CTNS CYSTINOSIN; CTNS
PSEUDOVAGINAL PERINEOSCROTAL HYPOSPADIAS; PPSH
BLOOM SYNDROME; BLM RECQ PROTEIN-LIKE 3; RECQL3
N-ACETYLGLUCOSAMINIDASE, ALPHA-; NAGLU MUCOPOLYSACCHARIDOSIS TYPE IIIB
CHARCOT-MARIE-TOOTH DISEASE 1B; CMT1B MYELIN PROTEIN ZERO; MPZ
SNP500 PANEL HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24
HOMOCYSTINURIA DUE TO DEFICIENCY OF N(5,10)-METHYLENETETRAHYDROFOLATE REDUCTASE ACTIVITY
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 SNP500 PANEL HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24
POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
POPULATION/CONVENIENCE CONTROL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
POPULATION/CONVENIENCE CONTROL DNA CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
CHROMOSOME 3 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 3 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; GALT GALACTOSEMIA
LIPASE, CONGENITAL ABSENCE OF PANCREATIC
GLYCOGEN STORAGE DISEASE II GLUCOSIDASE, ALPHA, ACID; GAA
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 8
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100
ACYL-CoA DEHYDROGENASE, SHORT-CHAIN, DEFICIENCY OF ACYL-CoA DEHYDROGENASE, SHORT-CHAIN; ACADS
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16
ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN, DEFICIENCY OF
ACYL-CoA DEHYDROGENASE, SHORT-CHAIN; ACADS ACYL-CoA DEHYDROGENASE, SHORT-CHAIN, DEFICIENCY OF
ACYL-CoA DEHYDROGENASE, SHORT/BRANCHED CHAIN; ACADSB
ACYL-CoA DEHYDROGENASE FAMILY, MEMBER 8; ACAD8 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY
NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16
OSTEOGENESIS IMPERFECTA, TYPE IV; OI4 APPARENTLY HEALTHY NON-FETAL TISSUE
CARNITINE PALMITOYLTRANSFERASE II DEFICIENCY, LATE-ONSET
TRIFUNCTIONAL PROTEIN DEFICIENCY HYDROXYACYL-CoA DEHYDROGENASE/3-KETOACYL-CoA THIOLASE/ENOYL-CoA HYDRATASE, BETA SUBUNIT; HADHB
BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE; BTK
LIG4 SYNDROME LIGASE IV, DNA, ATP-DEPENDENT; LIG4
ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1; NCIE1
YOUNG ONSET PARKINSON'S DISEASE; AFFECTED INDIVIDUALS PARKINSON'S DISEASE
CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS SPOUSAL CONTROL
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1)
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1) HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200
PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS
ADRENOLEUKODYSTROPHY, AUTOSOMAL NEONATAL FORM
SPOUSAL CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
17-@BETA-HYDROXYSTEROID DEHYDROGENASE IV; HSD17B4 PEROXISOMAL BIFUNCTIONAL ENZYME DEFICIENCY
PEROXISOMAL BIFUNCTIONAL ENZYME DEFICIENCY
PEROXISOMAL BIFUNCTIONAL ENZYME DEFICIENCY 17-@BETA-HYDROXYSTEROID DEHYDROGENASE IV; HSD17B4
EPILEPSY ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC 1; PFIC1
VAS DEFERENS, CONGENITAL BILATERAL APLASIA OF; CBAVD
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1)
NEURAMINIDASE DEFICIENCY WITH BETA-GALACTOSIDASE DEFICIENCY
NIEMANN-PICK DISEASE, TYPE A SPHINGOMYELIN PHOSPHODIESTERASE 1, ACID LYSOSOMAL; SMPD1
DEMENTIA WITH LEWY BODIES REM BEHAVIOR DISORDER
TRANSLOCATED CHROMOSOME ATAXIA-TELANGIECTASIA; AT ATAXIA-TELANGIECTASIA MUTATED GENE; ATM
CHROMOSOME 4 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC TURNER SYNDROME
HUMAN VARIATION PANEL - SOUTH AMERICA (ANDES)
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL POPULATION/CONVENIENCE CONTROL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL POPULATION/CONVENIENCE CONTROL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
TRICHOTHIODYSTROPHY; TTD ICHTHYOSIFORM ERYTHRODERMA WITH HAIR ABNORMALITY AND MENTAL AND GROWTH RETARDATION, INCLUDED
HUMAN VARIATION PANEL - SOUTH AMERICA (BRAZIL, GUYANA, AND VENEZUELA) SNP500 PANEL
HUMAN VARIATION PANEL - SOUTH AMERICA (BRAZIL, GUYANA, AND VENEZUELA)
CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 HUMAN VARIATION PANEL - SOUTH AMERICA (BRAZIL, GUYANA, AND VENEZUELA) SNP500 PANEL
SNP500 PANEL HUMAN VARIATION PANEL - SOUTH AMERICA (BRAZIL, GUYANA, AND VENEZUELA)
DYSTONIA MUSCULORUM DEFORMANS: TYPE UNKNOWN
ADENOSINE MONOPHOSPHATE DEAMINASE 1; AMPD1
MUCOLIPIDOSIS II; ML2; ML II N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE, ALPHA/BETA SUBUNITS; GNPTAB
XXY SYNDROME; KLINEFELTER SYNDROME ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
XERODERMA PIGMENTOSUM WITH NORMAL DNA REPAIR RATES
TAY-SACHS DISEASE; TSD HEXOSAMINIDASE A; HEXA
OSTEOGENESIS IMPERFECTA: GENETICS UNCERTAIN; NON-LETHAL
DYSTROPHIA MYOTONICA PROTEIN KINASE; DMPK DYSTROPHIA MYOTONICA 1
METAPHYSEAL DYSPLASIA, ANETODERMA, AND OPTIC ATROPHY
NIEMANN-PICK DISEASE, TYPE C1; NPC1 NPC1 GENE; NPC1
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 1 SOMATIC CELL HYBRIDS
HUMAN VARIATION PANEL - MIDDLE EASTERN (VERSION 2)
CHROMOSOME 10 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 16 SOMATIC CELL HYBRIDS
FANCONI ANEMIA, COMPLEMENTATION GROUP C; FANCC
PARKINSONISM, OTHER NEURODEGENERATIVE OVERLAP SYNDROME
NIGMS MAPPING PANEL #2, VERSION 3, HUMAN/RODENT SOMATIC CELL HYBRIDS
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP D; XPD
HUMAN VARIATION PANEL - ASHKENAZI JEWISH
HUMAN VARIATION PANEL - AFRICANS SOUTH OF THE SAHARA
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100
NDPT080 ISCHEMIC STROKE DNA PANEL ISCHEMIC STROKE
CHROMOSOME 12 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1)
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1) HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1) HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1)
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1) HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50
FANCONI ANEMIA, COMPLEMENTATION GROUP B; FANCB
CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS SPOUSAL CONTROL
SPOUSAL CONTROL CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES
CHROMOSOME 18 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1)
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA (PLATE II) INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA
INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA (PLATE I)
INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50
INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA (PLATE II)
INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA (PLATE I) INTERNATIONAL HAPMAP PROJECT - MAASAI IN KINYAWA, KENYA
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 SNP500 PANEL
EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HANSTER, 1; ERCC1 CEREBROOCULOFACIOSKELETAL SYNDROME 4; COFS4
MOSAIC VARIEGATED ANEUPLOIDY SYNDROME; MVA
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; GREATER THAN 7 YEARS SURVIVAL
SNP500 PANEL HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100
FANCONI ANEMIA, COMPLEMENTATION GROUP D1; FANCD1
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP B; XPB EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 3; ERCC3
ISCHEMIC STROKE NDPT080 ISCHEMIC STROKE DNA PANEL
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL CAUCASIAN FROM THE UNITED STATES
GLYPICAN 3; GPC3 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1; SGBS1
FRIEDREICH ATAXIA 1; FRDA FRDA GENE; FRDA
ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL CAUCASIAN FROM THE UNITED STATES
CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS POPULATION/CONVENIENCE CONTROL
SPOUSAL CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1) HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 50 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 1)
NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL SPOUSAL CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS POPULATION/CONVENIENCE CONTROL CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
HUMAN VARIATION PANEL - SOUTHEAST ASIANS (EXCLUDING JAPANESE AND CHINESE)
SNP500 PANEL HUMAN VARIATION PANEL - SOUTHEAST ASIANS (EXCLUDING JAPANESE AND CHINESE)
HUMAN VARIATION PANEL - SOUTHEAST ASIANS (EXCLUDING JAPANESE AND CHINESE) SNP500 PANEL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL SPOUSAL CONTROL
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US
ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL EPILEPSY
SPOUSAL CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
ALS PANEL CAUCASIAN FROM THE US ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS
SNP500 PANEL HUMAN VARIATION PANEL - MEXICAN
SNP500 PANEL HUMAN VARIATION PANEL - JAPANESE
ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE US
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS
HUMAN VARIATION PANEL - PUERTO RICAN SNP500 PANEL
SNP500 PANEL HUMAN VARIATION PANEL - PUERTO RICAN
HUMAN VARIATION PANEL - PUERTO RICAN SNP500 PANEL CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9
SNP500 PANEL HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 10
HUMAN VARIATION PANEL - MIDDLE EASTERN (VERSION 1)
ALS PANEL CAUCASIAN FROM THE US ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS AMYOTROPHIC LATERAL SCLEROSIS
UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1 SNP500 PANEL HUMAN VARIATION PANEL - JAPANESE
UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1 HUMAN VARIATION PANEL - JAPANESE SNP500 PANEL CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6
HUMAN VARIATION PANEL - JAPANESE CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9
HUMAN VARIATION PANEL - JAPANESE SNP500 PANEL
ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US
CRI-DU-CHAT SYNDROME CHROMOSOME DELETION
HUMAN VARIATION PANEL - INDO PAKISTANI SNP500 PANEL
DUPLICATED CHROMOSOME RECOMBINANT CHROMOSOME
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
HUMAN VARIATION PANEL - CHINESE (VERSION 2) SNP500 PANEL HUMAN VARIATION PANEL - CHINESE (VERSION 1)
SNP500 PANEL HUMAN VARIATION PANEL - CHINESE (VERSION 2) HUMAN VARIATION PANEL - CHINESE (VERSION 1)
TRANSLOCATED CHROMOSOME CRI-DU-CHAT SYNDROME DERIVATIVE CHROMOSOME
CHROMOSOME DELETION CRI-DU-CHAT SYNDROME
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 10 CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 5 SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 18 SOMATIC CELL HYBRIDS
ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE; AEZ
ANEUPLOID CHROMOSOME NUMBER - TRISOMY TRISOMY 21
ANEUPLOID CHROMOSOME NUMBER - TRISOMY 18 ANEUPLOID CHROMOSOME NUMBER - TRISOMY
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50
TURCOT SYNDROME ADENOMATOUS POLYPOSIS OF THE COLON; APC (GARDNER SYNDROME INCLUDED)
UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8 UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
SPOUSAL CONTROL CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8 UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE, ALPHA/BETA SUBUNITS; GNPTAB MUCOLIPIDOSIS II; ML2; ML II
EHLERS-DANLOS SYNDROME: TYPE UNCLASSIFIED
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 8
APPARENTLY HEALTHY NON-FETAL TISSUE XX MALE SYNDROME
XX MALE SYNDROME APPARENTLY HEALTHY NON-FETAL TISSUE
XX MALE SYNDROME TRANSLOCATED CHROMOSOME DERIVATIVE CHROMOSOME
INVERTED CHROMOSOME CRI-DU-CHAT SYNDROME DERIVATIVE CHROMOSOME
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 16 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50
HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 24 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 50 HUMAN VARIATION PANEL - AFRICAN AMERICAN PANEL OF 100
PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES PARKINSON'S DISEASE LEUCINE-RICH REPEAT KINASE2; LRRK2
PARKINSON'S DISEASE ESSENTIAL TREMOR-MOVEMENT DISORDER PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL SPOUSAL CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
ESSENTIAL TREMOR-MOVEMENT DISORDER RESTLESS LEG SYNDROME PARKINSON'S DISEASE
PARKINSON'S DISEASE LEUCINE-RICH REPEAT KINASE2; LRRK2
INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 GUJARATI INDIANS IN HOUSTON, TEXAS INTERNATIONAL HAPMAP PROJECT - GUJARATI INDIANS IN HOUSTON, TEXAS
INTERNATIONAL HAPMAP PROJECT - GUJARATI INDIANS IN HOUSTON, TEXAS INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 GUJARATI INDIANS IN HOUSTON, TEXAS
INTERNATIONAL HAPMAP PROJECT - GUJARATI INDIANS IN HOUSTON, TEXAS
ANEUPLOID CHROMOSOME NUMBER - TRISOMY 18
PHOSPHOMANNOMUTASE 2; PMM2 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ia
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Id ALG3, S. CEREVISIAE, HOMOLOG OF; ALG3
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ia
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ic ALG6, S. CEREVISIAE, HOMOLOG OF
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ia PHOSPHOMANNOMUTASE 2; PMM2
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ie DOLICHYL-PHOSPHATE MANNOSYLTRANSFERASE 1, CATALYTIC SUBUNIT; DPM1
DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINE PHOSPHOTRANSFERASE; DPAGT1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ij
HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN
HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN APPARENTLY HEALTHY NON-FETAL TISSUE
VALOSIN-CONTAINING PROTEIN; VCP INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA; IBMPFD
MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1; MPDU1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE If
INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 HAN CHINESE IN METROPOLITAN DENVER, COLORADO INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN METROPOLITAN DENVER, COLORADO
INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN METROPOLITAN DENVER, COLORADO INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 HAN CHINESE IN METROPOLITAN DENVER, COLORADO
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200 HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 2)
INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN METROPOLITAN DENVER, COLORADO
LYMPHOSARCOMA ACUTE LYMPHOCYTIC LEUKEMIA
N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE, ALPHA/BETA SUBUNITS; GNPTAB MUCOLIPIDOSIS IIIA
MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD DYSTROPHIN; DMD
DYSTROPHIA MYOTONICA PROTEIN KINASE; DMPK DYSTROPHIA MYOTONICA 1 5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR
TRANSLOCATED CHROMOSOME CENTRAL CORE DISEASE OF MUSCLE
Donor subject has two copies of the SMN2 and is heterozygous for deletion of exons 7 and 8 in the SMN1 gene
Cell provider: Coriell Cell Repository; Cell provider catalog number: Coriell Cell Repository
RETINITIS PIGMENTOSA - 180100, 268000, OR 312600
MACULAR DYSTROPHY, RETINAL, 1, NORTH CAROLINA TYPE; MCDR1
SPOUSAL CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
AMAUROSIS CONGENITA OF LEBER; TYPE I OR II - 204000 OR 204100
SPOUSAL CONTROL CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL SPOUSAL CONTROL
ALKALINE PHOSPHATASE, LIVER; ALPL HYPOPHOSPHATASIA, INFANTILE
ROKITANSKY-KUSTER-HAUSER SYNDROME UROGENITAL ADYSPLASIA, HEREDITARY
EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 3; ERCC3 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP B; XPB
HUNTINGTON DISEASE; HD APPARENTLY HEALTHY NON-FETAL TISSUE
PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS HEMOCHROMATOSIS; HFE
ADENOMATOUS POLYPOSIS OF THE COLON; APC (GARDNER SYNDROME INCLUDED)
HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 100 (SET 2) HUMAN VARIATION PANEL - CAUCASIAN PANEL OF 200
TRANSLOCATED CHROMOSOME KLIPPEL-FEIL SYNDROME; KFS; KFM CERVICAL VERTEBRAL FUSION, TYPE II, INCLUDED
DYSTROPHIA MYOTONICA 1 DYSTROPHIA MYOTONICA PROTEIN KINASE; DMPK
APOLIPOPROTEIN C-II DEFICIENCY, TYPE I HYPERLIPOPROTEINEMIA DUE TO
ADENOMATOUS POLYPOSIS OF THE COLON; APC (GARDNER SYNDROME INCLUDED) APPARENTLY HEALTHY NON-FETAL TISSUE
PARKINSONISM, OTHER DEMENTIA WITH LEWY BODIES
ANEUPLOID CHROMOSOME NUMBER - TRISOMY SC PHOCOMELIA SYNDROME
MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2; LGMD2
DYSTROPHIA MYOTONICA 1 APPARENTLY HEALTHY NON-FETAL TISSUE
CYSTINOSIN; CTNS CYSTINOSIS, NEPHROPATHIC; CTNS
HERMANSKY-PUDLAK SYNDROME; HPS HERMANSKY-PUDLAK SYNDROME GENE 6
NORMAL CHROMOSOMAL POLYMORPHISM APPARENTLY HEALTHY NON-FETAL TISSUE
CYSTINOSIS, ADULT NONNEPHROPATHIC CYSTINOSIN; CTNS
ADAPTOR-RELATED PROTEIN COMPLEX 3, BETA-1 SUBUNIT; AP3B1 HERMANSKY-PUDLAK SYNDROME 2; HPS2
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC XXY SYNDROME; KLINEFELTER SYNDROME
NIEMANN-PICK DISEASE, TYPE C2 NPC2 GENE; NPC2
ACUTE LYMPHOCYTIC LEUKEMIA LYMPHOSARCOMA
OSTEOGENESIS IMPERFECTA: AUTOSOMAL RECESSIVE - 259400, 259410, OR 259420
FSHD GENE 1; FRG1 FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1A; FSHMD1A (FSHD)
WOLF-HIRSCHHORN SYNDROME; WHS CHROMOSOME DELETION
MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD
CARNITINE DEFICIENCY, SYSTEMIC PRIMARY; CDSP
APPARENTLY HEALTHY NON-FETAL TISSUE OSTEOGENESIS IMPERFECTA, TYPE IV; OI4
ANKYLOBLEPHARON-ECTODERMAL DEFECTS-CLEFT LIP/PALATE
FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1A; FSHMD1A (FSHD) FSHD GENE 1; FRG1
HEMOCHROMATOSIS; HFE APPARENTLY HEALTHY NON-FETAL TISSUE APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS
APPARENTLY HEALTHY NON-FETAL TISSUE APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS
CHROMOSOME DELETION CHRONIC GRANULOMATOUS DISEASE (XK-RELATED; CGD) - 306400 OR 314850
PARKINSON'S DISEASE AMYOTROPHIC LATERAL SCLEROSIS LATE ONSET PARKINSON'S DNA PANEL, AFFECTED INDIVIDUALS
HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2) CYSTIC FIBROSIS; CF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR
OSTEOPETROSIS WITH RENAL TUBULAR ACIDOSIS
APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS APPARENTLY HEALTHY NON-FETAL TISSUE
MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD CHRONIC GRANULOMATOUS DISEASE (XK-RELATED; CGD) - 306400 OR 314850 DYSTROPHIN; DMD
DYSTROPHIN; DMD CHRONIC GRANULOMATOUS DISEASE (XK-RELATED; CGD) - 306400 OR 314850 MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100
ANEUPLOID CHROMOSOME NUMBER - TRISOMY ANEUPLOID CHROMOSOME NUMBER - TRISOMY 9
ADRENOLEUKODYSTROPHY; ALD ATP-BINDING CASSETTE, SUBFAMILY D, MEMBER 1; ABCD1
PANTOTHENATE KINASE-ASSOCIATED NEURODEGENERATION; PKAN; HALLERVORDEN-SPATZ DISEASE INCLUDED PANTOTHENATE KINASE 2; PANK2
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100
ANEUPLOID CHROMOSOME NUMBER - TRISOMY ANEUPLOID CHROMOSOME NUMBER - TRISOMY 13
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8
MUCOLIPIDOSIS III, COMPLEMENTATION GROUP C
PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES PARKINSON'S DISEASE
CHEDIAK-HIGASHI SYNDROME; CHS1 LYSOSOMAL TRAFFICKING REGULATOR, INCLUDED; LYST, INCLUDED
MUCOPOLYSACCHARIDOSIS TYPE IVB GANGLIOSIDOSIS, GENERALIZED GM1, TYPE I
SPOUSAL CONTROL ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
CEREBRAL CALCIFICATION, NONARTERIOSCLEROTIC
EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 2; ERCC2 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP D; XPD
NEUROBLASTOMA; NB NEUROBLASTOMA SUPPRESSOR, INCLUDED; NBS, INCLUDED
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR 5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2) CYSTIC FIBROSIS; CF
CEPH/UTAH PEDIGREE 13291 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
TUBEROUS SCLEROSIS; TS APPARENTLY HEALTHY NON-FETAL TISSUE
PEROXISOME BIOGENESIS FACTOR 26; PEX26 ZELLWEGER SYNDROME; ZS
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1345
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 SNP500 PANEL HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 CEPH/UTAH PEDIGREE 1345
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 SNP500 PANEL HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 CEPH/UTAH PEDIGREE 1345
CEPH/UTAH PEDIGREE 1345 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1345
CYSTINURIA; CSNU SOLUTE CARRIER FAMILY 3, MEMBER 1; SLC3A1
SOLUTE CARRIER FAMILY 17, MEMBER 5; SLC17A5 SALLA DISEASE
FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY; TYPE UNKNOWN (FSHD)
AUTISTIC DISORDER TRANSLOCATED CHROMOSOME
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16
SALLA DISEASE SOLUTE CARRIER FAMILY 17, MEMBER 5; SLC17A5
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR APPARENTLY HEALTHY NON-FETAL TISSUE
HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE 1; HPRT1; HPRT LESCH-NYHAN SYNDROME; LNS
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16
HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - HAN PEOPLE OF LOS ANGELES PANEL OF 8
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 SNP500 PANEL
HYPERAMMONEMIA DUE TO CARBAMOYLPHOSPHATE SYNTHETASE I DEFICIENCY
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 SNP500 PANEL
SNP500 PANEL HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100
HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 16 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 8 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 100 HUMAN VARIATION PANEL - MEXICAN-AMERICAN COMMUNITY OF LOS ANGELES PANEL OF 24
ANEUPLOID CHROMOSOME NUMBER - TRISOMY ANEUPLOID CHROMOSOME NUMBER - TRISOMY 18
DYSTROPHIN; DMD MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD
MYELOMA (PLASMACYTOMA) CELL LINES FOR HYBRIDOMAS
DIGEORGE SYNDROME; DGS TRANSLOCATED CHROMOSOME
PSEUDOHERMAPHRODITISM, MALE, WITH GYNECOMASTIA
PARKINSON'S DISEASE ESSENTIAL TREMOR-MOVEMENT DISORDER
NEPHROSIS 1, CONGENITAL, FINNISH TYPE; NPHS1
NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008
FANCONI ANEMIA, COMPLEMENTATION GROUP D2; FANCD2
FANCONI ANEMIA, COMPLEMENTATION GROUP G; FANCG X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 9; XRCC9
MULTIPLE ENDOCRINE NEOPLASIA, TYPE II; MEN2 RET PROTOONCOGENE; RET
FACTOR V DEFICIENCY HEMOGLOBIN--BETA LOCUS; HBB
HUMAN VARIATION PANEL - CHINESE (VERSION 2) CHINESE POPULATION
ALS PANEL CAUCASIAN FROM THE UNITED STATES AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES
ALZHEIMER DISEASE LATE ONSET PARKINSON'S DNA PANEL, AFFECTED INDIVIDUALS PARKINSON'S DISEASE
CHROMOSOME DELETION MILLER-DIEKER LISSENCEPHALY SYNDROME; MDLS
RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 3; RCDP3
RET PROTOONCOGENE; RET MULTIPLE ENDOCRINE NEOPLASIA, TYPE II; MEN2
CEPH/UTAH PEDIGREE 1355 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1353 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
ALS PANEL; GREATER THAN 7 YEARS SURVIVAL AMYOTROPHIC LATERAL SCLEROSIS
PEROXISOME BIOGENESIS FACTOR 1; PEX1 ZELLWEGER SYNDROME; ZS
SOLUTE CARRIER FAMILY 3, MEMBER 1; SLC3A1 CYSTINURIA; CSNU
CEROID LIPOFUSCINOSIS, NEURONAL 2, LATE INFANTILE TYPE; CLN2 CLN2 GENE; CLN2
RETINITIS PIGMENTOSA 1; RP1 REFSUM DISEASE
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 18 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 4 SOMATIC CELL HYBRIDS
CHROMOSOME 9 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ABDOMINAL MUSCLES, ABSENCE OF, WITH URINARY TRACT ABNORMALITY AND CRYPTORCHIDISM
ESSENTIAL TREMOR-MOVEMENT DISORDER POPULATION/CONVENIENCE CONTROL
MELANOMA, CUTANEOUS MALIGNANT, 2; CMM2 CYCLIN-DEPENDENT KINASE INHIBITOR 2A; CDKN2A
CYCLIN-DEPENDENT KINASE INHIBITOR 2A; CDKN2A MELANOMA, CUTANEOUS MALIGNANT, 2; CMM2
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS
ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS AMYOTROPHIC LATERAL SCLEROSIS
FRONTOTEMPORAL DEMENTIA AMYOTROPHIC LATERAL SCLEROSIS
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 CEPH/FRENCH PEDIGREE 12
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 18 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 1 SOMATIC CELL HYBRIDS
MAJOR AFFECTIVE DISORDER - 125480 OR 309200 TRANSLOCATED CHROMOSOME
ALS PANEL CAUCASIAN FROM THE UNITED STATES FRONTOTEMPORAL DEMENTIA AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
ALS PANEL CAUCASIAN FROM THE UNITED STATES AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 14 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 18 SOMATIC CELL HYBRIDS
CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE X CHROMOSOME SOMATIC CELL HYBRIDS
DANDY-WALKER MALFORMATION WITH MENTAL RETARDATION, BASAL GANGLIA DISEASE, AND SEIZURES
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 17 SOMATIC CELL HYBRIDS
CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
PHYLOGENETIC SHADOWING PANEL NONHUMAN PRIMATES
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1353
CEPH/FRENCH PEDIGREE 66 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24
HUMAN VARIATION PANEL - CHINESE (VERSION 2) HUMAN VARIATION PANEL - CHINESE (VERSION 1) SNP500 PANEL
HUMAN VARIATION PANEL - CHINESE (VERSION 1) HUMAN VARIATION PANEL - CHINESE (VERSION 2) SNP500 PANEL
HUMAN VARIATION PANEL - NORTHERN EUROPEAN
HUMAN VARIATION PANEL - CHINESE (VERSION 1)
HUMAN VARIATION PANEL - CHINESE (VERSION 2) HUMAN VARIATION PANEL - CHINESE (VERSION 1)
ALS PANEL; GREATER THAN 7 YEARS SURVIVAL ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
ORNITHINE CARBAMOYLTRANSFERASE; OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY, HYPERAMMONEMIA DUE TO; OTC
POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1; PKHD1
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC CHROMOSOME DELETION
ALS PANEL; GREATER THAN 7 YEARS SURVIVAL AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES
EMERIN; EMD EMERY-DREIFUSS MUSCULAR DYSTROPHY
ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS AMYOTROPHIC LATERAL SCLEROSIS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; GREATER THAN 7 YEARS SURVIVAL
APPARENTLY HEALTHY NON-FETAL TISSUE HUNTINGTON DISEASE; HD
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS
CHIMPANZEE PANEL GREAT APE PANEL NONHUMAN PRIMATES
ALEXANDER DISEASE GLIAL FIBRILLARY ACIDIC PROTEIN; GFAP
GLIAL FIBRILLARY ACIDIC PROTEIN; GFAP ALEXANDER DISEASE
RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 2; RCDP2
DELETED IN AZOOSPERMIA; DAZ CHROMOSOME DELETION
CYSTINURIA; CSNU SOLUTE CARRIER FAMILY 7, MEMBER 9; SLC7A9
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3 INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP
FANCONI ANEMIA, COMPLEMENTATION GROUP F; FANCF
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3 INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP MONOZYGOTIC TWIN PAIRS
CEPH/UTAH PEDIGREE 1358 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1358
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1358
NONHUMAN PRIMATES PHYLOGENETIC SHADOWING PANEL
CONGENITAL ENDPLATE ACETYLCHOLINESTERASE DEFICIENCY
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 POPULATION/CONVENIENCE CONTROL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1; EEC1
ALS PANEL; GREATER THAN 7 YEARS SURVIVAL PRIMARY LATERAL SCLEROSIS
BASQUE POPULATION HUMAN VARIATION PANEL - BASQUE
HUMAN VARIATION PANEL - BASQUE BASQUE POPULATION
SPOUSAL CONTROL NDPT031- AFRICAN AMERICAN CONTROL PANEL
ECTODERMAL DYSPLASIA 1, ANHIDROTIC; ED1 TRANSLOCATED CHROMOSOME
ALS PANEL CAUCASIAN FROM THE UNITED STATES AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
ALS PANEL CAUCASIAN FROM THE US ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES
NIJMEGEN BREAKAGE SYNDROME GENE; NBS1 NIJMEGEN BREAKAGE SYNDROME
COAGULATION FACTOR II; F2 HEMOCHROMATOSIS; HFE 5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR HUMAN GENE MUTATION PANEL - HEMOCHROMATOSIS HUMAN GENE MUTATION PANEL - DISORDERS OF THROMBOSIS
MONOZYGOTIC TWIN PAIRS EPILEPSY, CHILDHOOD ABSENCE, 1; ECA1
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS
CEROID LIPOFUSCINOSIS, NEURONAL 1, INFANTILE; CLN1 PALMITOYL-PROTEIN THIOESTERASE 1; PPT1
PALMITOYL-PROTEIN THIOESTERASE 1; PPT1 CEROID LIPOFUSCINOSIS, JUVENILE NEURONAL, WITH GRANULAR OSMIOPHILIC DEPOSIT
DERIVATIVE CHROMOSOME TRANSLOCATED CHROMOSOME
HUMAN GENE MUTATION PANEL - HEMOCHROMATOSIS 5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR FACTOR V DEFICIENCY HUMAN GENE MUTATION PANEL - DISORDERS OF THROMBOSIS COAGULATION FACTOR II; F2 HEMOCHROMATOSIS; HFE
LIGASE IV, DNA, ATP-DEPENDENT; LIG4 LIG4 SYNDROME
PALMITOYL-PROTEIN THIOESTERASE 1; PPT1 CEROID LIPOFUSCINOSIS, NEURONAL 1, INFANTILE; CLN1
APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS MONOZYGOTIC TWIN PAIRS APPARENTLY HEALTHY NON-FETAL TISSUE
MONOZYGOTIC TWIN PAIRS APPARENTLY HEALTHY NON-FETAL TISSUE APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS
APPARENTLY HEALTHY NON-FETAL TISSUE MONOZYGOTIC TWIN PAIRS APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS
APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS APPARENTLY HEALTHY NON-FETAL TISSUE MONOZYGOTIC TWIN PAIRS
TRANSLOCATED CHROMOSOME FANCONI ANEMIA, COMPLEMENTATION GROUP C; FANCC
CHARCOT-MARIE-TOOTH PERONEAL MUSCULAR ATROPHY, X-LINKED; CMTX1 GAP JUNCTION PROTEIN, BETA-1, 32-KD; GJB1
GAP JUNCTION PROTEIN, BETA-1, 32-KD; GJB1 CHARCOT-MARIE-TOOTH PERONEAL MUSCULAR ATROPHY, X-LINKED; CMTX1
APPARENTLY HEALTHY NON-FETAL TISSUE ANEUPLOID CHROMOSOME NUMBER - TRISOMY 18
INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP PARKINSON'S DISEASE NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3 INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP PARKINSON'S DISEASE
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3 INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP ASPARTOACYLASE; ASPA
INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3 GLUCOSIDASE, ACID BETA; GBA
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1375 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
MYELOMA, MULTIPLE AMYLOIDOSIS, PRIMARY, INCLUDED; AL, INCLUDED
PRIMARY LATERAL SCLEROSIS ALS PANEL; GREATER THAN 7 YEARS SURVIVAL
PRADER-WILLI SYNDROME; PWS DUPLICATED CHROMOSOME
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1334 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1334 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CEPH/UTAH PEDIGREE 1334 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1408
CEPH/UTAH PEDIGREE 1408 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
PERIPHERAL MYELIN PROTEIN 22; PMP22 CHARCOT-MARIE-TOOTH DISEASE, TYPE 1A; CMT1A
ADRENAL HYPERPLASIA, CONGENITAL, DUE TO 21-HYDROXYLASE DEFICIENCY
CEPH/UTAH PEDIGREE 1408 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1416 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1334
FRDA GENE; FRDA FRIEDREICH ATAXIA 1; FRDA
NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM INVERTED CHROMOSOME
KEARNS-SAYRE SYNDROME; KSS COMPLEX I, SUBUNIT ND4; MTND4
APPARENTLY HEALTHY NON-FETAL TISSUE FABRY DISEASE
SUBARACHNOID HEMORRHAGE INTRACRANIAL ANEURYSM - UNRUPTURED
NIEMANN-PICK DISEASE, TYPE B SPHINGOMYELIN PHOSPHODIESTERASE 1, ACID LYSOSOMAL; SMPD1 GLUCOSIDASE, ACID BETA; GBA
SPHINGOMYELIN PHOSPHODIESTERASE 1, ACID LYSOSOMAL; SMPD1 NIEMANN-PICK DISEASE, TYPE A
CEPH/UTAH PEDIGREE 1421 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
POPLITEAL PTERYGIUM SYNDROME, LETHAL TYPE; BARTSOCAS-PAPAS SYNDROME; BPS
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1418
CEPH/UTAH PEDIGREE 1418 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] SNP500 PANEL
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1421
PINEAL HYPERPLASIA, INSULIN-RESISTANT DIABETES MELLITUS, AND SOMATIC ABNORMALITIES; RABSON-MENDENHALL SYNDROME LEPRECHAUNISM
HYPOPARATHYROIDISM-RETARDATION-DYSMORPHISM SYNDROME; HRD; SANJAD-SAKATI SYNDROME
FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY; TYPE UNKNOWN (FSHD) TURNER SYNDROME
CEPH/UTAH PEDIGREE 1418 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
SICKLE CELL ANEMIA HEMOGLOBIN--BETA LOCUS; HBB
HEMOGLOBIN--BETA LOCUS; HBB SICKLE CELL ANEMIA
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 7 SOMATIC CELL HYBRIDS CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
HYPOPHOSPHATASIA, INFANTILE ALKALINE PHOSPHATASE, LIVER; ALPL
GLUTARICACIDEMIA I GLUTARYL-COA DEHYDROGENASE; GCDH
GLUTARYL-COA DEHYDROGENASE; GCDH GLUTARICACIDEMIA I
EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 5; ERCC5 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G; XPG
APPARENTLY HEALTHY NON-FETAL TISSUE INVERTED CHROMOSOME
GERONTOLOGY RESEARCH CENTER (GRC) CELL CULTURE COLLECTION BALTIMORE LONGITUDINAL STUDY ON AGING (BLSA)
BALTIMORE LONGITUDINAL STUDY ON AGING (BLSA) APPARENTLY HEALTHY NON-FETAL TISSUE GERONTOLOGY RESEARCH CENTER (GRC) CELL CULTURE COLLECTION
APPARENTLY HEALTHY NON-FETAL TISSUE INVERTED CHROMOSOME BALTIMORE LONGITUDINAL STUDY ON AGING (BLSA) GERONTOLOGY RESEARCH CENTER (GRC) CELL CULTURE COLLECTION
APPARENTLY HEALTHY NON-FETAL TISSUE BALTIMORE LONGITUDINAL STUDY ON AGING (BLSA) GERONTOLOGY RESEARCH CENTER (GRC) CELL CULTURE COLLECTION
INVERTED CHROMOSOME NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
CEPH/UTAH PEDIGREE 13281 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1328 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1330
CEPH/UTAH PEDIGREE 1330 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 13281
X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 4; XRCC4 CRICETULUS
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G; XPG EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 5; ERCC5
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1354
CEPH/UTAH PEDIGREE 1354 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
AMYOTROPHIC LATERAL SCLEROSIS FRONTOTEMPORAL DEMENTIA
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CYSTIC FIBROSIS; CF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2)
CEPH/UTAH PEDIGREE 1349 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1349 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1349 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1377
CEPH/UTAH PEDIGREE 1377 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1347 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1347 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1350 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CEPH/UTAH PEDIGREE 1350 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1350 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1350 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE US
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL CAUCASIAN FROM THE US ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS AMYOTROPHIC LATERAL SCLEROSIS
DNA CONTROL PANEL FOR LATE ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
CEPH/UTAH PEDIGREE 1423 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1423
MYOCLONUS EPILEPSY ASSOCIATED WITH RAGGED-RED FIBERS; MERFF TRANSFER RNA, MITOCHONDRIAL, LYSINE; MTTK
CHROMOSOME 11 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 11 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 11 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1424
CEPH/UTAH PEDIGREE 1424 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
ALS PANEL; GREATER THAN 7 YEARS SURVIVAL AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1346
CEPH/UTAH PEDIGREE 1346 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1346 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTRACEREBRAL HEMORRHAGE SUBARACHNOID HEMORRHAGE
TRANSLOCATED CHROMOSOME DERIVATIVE CHROMOSOME
LESCH-NYHAN SYNDROME; LNS HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE 1; HPRT1; HPRT
MEVALONATE KINASE; MVK MEVALONICACIDURIA, INCLUDED
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1420 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CEPH/UTAH PEDIGREE 1420 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1420
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1420 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1362 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1362 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9
CEPH/UTAH PEDIGREE 1362 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 SNP500 PANEL INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1362 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 10 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
18Q- SYNDROME APPARENTLY HEALTHY NON-FETAL TISSUE
ALS PANEL CAUCASIAN FROM THE UNITED STATES PRIMARY LATERAL SCLEROSIS
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS
ADDITIONAL HUMAN/CHINESE HAMSTER SOMATIC CELL HYBRIDS
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1344
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1344 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1344 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS ALS PANEL CAUCASIAN FROM THE US ALS PANEL CAUCASIAN FROM THE UNITED STATES AMYOTROPHIC LATERAL SCLEROSIS
V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG; KIT PIEBALD TRAIT; PBT
CHROMOSOME 7 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 18 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 4 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CANIS CANINE GANGLIOSIDOSIS, GENERALIZED GM1, TYPE 1
CHROMOSOME 4 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 12 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 4 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 6 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ANGELMAN SYNDROME; AS CHROMOSOME DELETION
CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
SNP500 PANEL CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 DRUZE POPULATION
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE UNITED STATES
ALS PANEL CAUCASIAN FROM THE UNITED STATES AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; GREATER THAN 7 YEARS SURVIVAL
FAMILIAL OPTIC ATROPHY; TYPE UNKNOWN; LEBER-LIKE OPTIC ATROPHY COMPLEX I, SUBUNIT ND1; MTND1
HOLOCARBOXYLASE SYNTHETASE; HLCS HOLOCARBOXYLASE SYNTHETASE DEFICIENCY
CHROMOSOME 13 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 17 SOMATIC CELL HYBRIDS CHROMOSOME 22 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
EWING SARCOMA BREAKPOINT REGION 1; EWSR1, INCLUDED; EWS, INCLUDED; ES, INCLUDED TRANSLOCATED CHROMOSOME
MULTIPLE ENDOCRINE NEOPLASIA, TYPE I; MEN1
NEUROMATA, MUCOSAL, WITH ENDOCRINE TUMORS
ICHTHYOSIS CONGENITA, HARLEQUIN FETUS TYPE
CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 3 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 7 SOMATIC CELL HYBRIDS CHROMOSOME 3 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
BALTIMORE LONGITUDINAL STUDY ON AGING (BLSA) GERONTOLOGY RESEARCH CENTER (GRC) CELL CULTURE COLLECTION
ALZHEIMER DISEASE; AD NIA AGING CELL REPOSITORY DNA PANEL - LATE ONSET FAMILIAL ALZHEIMER DISEASE APOLIPOPROTEIN E; APOE
NIA AGING CELL REPOSITORY DNA PANEL - CHARACTERIZED MUTATIONS ALZHEIMER DISEASE; AD
APOLIPOPROTEIN E; APOE ALZHEIMER DISEASE; AD NIA AGING CELL REPOSITORY DNA PANEL - LATE ONSET FAMILIAL ALZHEIMER DISEASE
AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
LAMIN A/C; LMNA HUTCHINSON-GILFORD PROGERIA SYNDROME; HGPS
HUTCHINSON-GILFORD PROGERIA SYNDROME; HGPS
NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES HUTCHINSON-GILFORD PROGERIA SYNDROME; HGPS LAMIN A/C; LMNA
ANEUPLOID CHROMOSOME NUMBER - TRISOMY 13
LAMIN A/C; LMNA HUTCHINSON-GILFORD PROGERIA SYNDROME; HGPS NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
HUTCHINSON-GILFORD PROGERIA SYNDROME; HGPS LAMIN A/C; LMNA NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
SV40 VIRUS-TRANSFORMED APPARENTLY HEALTHY: NON-FETAL TISSUE
ALZHEIMER DISEASE; AD NIA AGING CELL REPOSITORY DNA PANEL - EARLY ONSET FAMILIAL ALZHEIMER DISEASE APOLIPOPROTEIN E; APOE
NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM AGED SIB PAIRS COLLECTION
NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS
NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM AGED SIB PAIRS COLLECTION
WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED RECQ PROTEIN-LIKE 2; RECQL2
NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS AGED SIB PAIRS COLLECTION
AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS
NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS
NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM AGED SIB PAIRS COLLECTION
ALZHEIMER DISEASE, FAMILIAL, TYPE 4 PRESENILIN 2; PSEN2
MRC-5 - SV40 VIRUS-TRANSFORMED FETAL LUNG FIBROBLAST
APOLIPOPROTEIN E; APOE ALZHEIMER DISEASE; AD NIA AGING CELL REPOSITORY DNA PANEL - EARLY ONSET FAMILIAL ALZHEIMER DISEASE
NIA AGING CELL REPOSITORY DNA PANEL - EARLY ONSET FAMILIAL ALZHEIMER DISEASE ALZHEIMER DISEASE; AD APOLIPOPROTEIN E; APOE
NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM APPARENTLY HEALTHY NON-FETAL TISSUE
NIA AGING CELL REPOSITORY DNA PANEL - CHARACTERIZED MUTATIONS PRESENILIN 2; PSEN2 ALZHEIMER DISEASE, FAMILIAL, TYPE 4
PRESENILIN 2; PSEN2 ALZHEIMER DISEASE, FAMILIAL, TYPE 4
AVM-UNRUPTURED AMYOTROPHIC LATERAL SCLEROSIS
INVERTED CHROMOSOME APPARENTLY HEALTHY NON-FETAL TISSUE
ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS PROGRESSIVE MUSCULAR ATROPHY
APPARENTLY HEALTHY NON-FETAL TISSUE NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM APPARENTLY HEALTHY NON-FETAL TISSUE NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED RECQ PROTEIN-LIKE 2; RECQL2 DERIVATIVE CHROMOSOME
RECQ PROTEIN-LIKE 2; RECQL2 WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED
AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS
ALZHEIMER DISEASE; AD APOLIPOPROTEIN E; APOE NIA AGING CELL REPOSITORY DNA PANEL - LATE ONSET FAMILIAL ALZHEIMER DISEASE
NIA AGING CELL REPOSITORY DNA PANEL - EARLY ONSET FAMILIAL ALZHEIMER DISEASE APOLIPOPROTEIN E; APOE ALZHEIMER DISEASE; AD
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1458
NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY DNA PANEL - LONGEVITY RESEARCH PROGRAM
CEPH/UTAH PEDIGREE 1358 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1358 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1447 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1447 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CEPH/UTAH PEDIGREE 1451 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1451
CEPH/UTAH PEDIGREE 1444 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1444 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1444
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1447
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1444
CEPH/UTAH PEDIGREE 1444 SNP500 PANEL INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1454 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 SNP500 PANEL CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1454
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1454
CEPH/UTAH PEDIGREE 1454 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1456
CEPH/UTAH PEDIGREE 1456 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
NIA AGING CELL REPOSITORY DNA PANEL - AGED SIB PAIRS AGED SIB PAIRS COLLECTION NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1454 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTRACRANIAL ANEURYSM - UNRUPTURED SUBARACHNOID HEMORRHAGE
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CEPH/UTAH PEDIGREE 1400 SNP500 PANEL
CEPH/UTAH PEDIGREE 1459 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1459
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1459 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1459 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CEPH/UTAH PEDIGREE 1459 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1463 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1463
CEPH/UTAH PEDIGREE 1463 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1463
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1463 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR VAS DEFERENS, CONGENITAL BILATERAL APLASIA OF; CBAVD
SEX REVERSAL, AUTOSOMAL, 2; SRA2 TRANSLOCATED CHROMOSOME
CEPH/UTAH PEDIGREE 1582 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 SNP500 PANEL
WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED
NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED
WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
GLUCOSIDASE, ALPHA, ACID; GAA GLYCOGEN STORAGE DISEASE II
HPS1 GENE; HPS1 HERMANSKY-PUDLAK SYNDROME; HPS
NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES COCKAYNE SYNDROME TYPE I - 216400 OR TYPE III - 216411
CHROMOSOME 11 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 22 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 22 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 15 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
MAPLE SYRUP URINE DISEASE (MSUD), TYPE IA
RHODOPSIN; RHO RETINITIS PIGMENTOSA, RHODOPSIN-RELATED, INCLUDED RETINITIS PIGMENTOSA - 180100, 268000, OR 312600
CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 10 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 3 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
SPINAL AND BULBAR MUSCULAR ATROPHY, X-LINKED 1; SMAX1
TRICHOTHIODYSTROPHY, NONPHOTOSENSITIVE 1; TTDN1 TTDN1 GENE; TTDN1 (C7ORF11)
TTDN1 GENE; TTDN1 (C7ORF11) TRICHOTHIODYSTROPHY, NONPHOTOSENSITIVE 1; TTDN1
ALBUMIN; ALB DYSALBUMINEMIC HYPERTHYROXINEMIA, INCLUDED INVERTED CHROMOSOME
ZELLWEGER SYNDROME; ZS INVERTED CHROMOSOME
EHLERS-DANLOS SYNDROME: TYPE IV; ARTERIAL, ECCHYMOTIC TYPE
FELINE EHLERS-DANLOS SYNDROME: TYPE UNCLASSIFIED FELIS
HURLER SYNDROME ALPHA-L-IDURONIDASE; IDUA
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC RING CHROMOSOME
MARKER CHROMOSOME OCULAR ALBINISM WITH CHROMOSOME ABNORMALITY; POSSIBLE AUTO RECESSIVE INHERITANCE
CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME DELETION GILLES DE LA TOURETTE SYNDROME; GTS
RETINITIS PIGMENTOSA - 180100, 268000, OR 312600 RHODOPSIN; RHO RETINITIS PIGMENTOSA, RHODOPSIN-RELATED, INCLUDED
TRANSLOCATED CHROMOSOME NEUROBLASTOMA; NB NEUROBLASTOMA SUPPRESSOR, INCLUDED; NBS, INCLUDED
TRANSLOCATED CHROMOSOME MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD
OCULAR ALBINISM WITH CHROMOSOME ABNORMALITY; POSSIBLE AUTO RECESSIVE INHERITANCE MARKER CHROMOSOME
CHROMOSOME DELETION GREIG CEPHALOPOLYSYNDACTYLY SYNDROME; GCPS
XERODERMIC IDIOCY OF DE SANCTIS AND CACCHIONE EXCISION-REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 6; ERCC6 COCKAYNE SYNDROME, TYPE B, INCLUDED; CSB, INCLUDED
EXCISION-REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 6; ERCC6 COCKAYNE SYNDROME, TYPE B, INCLUDED; CSB, INCLUDED XERODERMIC IDIOCY OF DE SANCTIS AND CACCHIONE
APPARENTLY HEALTHY NON-FETAL TISSUE THANATOPHORIC DYSPLASIA; TD
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 22 SOMATIC CELL HYBRIDS
TRANSLOCATED CHROMOSOME CHROMOSOME DELETION
MILLER-DIEKER LISSENCEPHALY SYNDROME; MDLS RING CHROMOSOME
ATAXIN 3; ATXN3 MACHADO-JOSEPH DISEASE; MJD
SCHINZEL-GIEDION MIDFACE-RETRACTION SYNDROME
MACHADO-JOSEPH DISEASE; MJD ATAXIN 3; ATXN3
APPARENTLY HEALTHY NON-FETAL TISSUE HEMOCHROMATOSIS; HFE 5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR HUMAN GENE MUTATION PANEL - HEMOCHROMATOSIS APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL PSYCHIATRIC EVALUATIONS
MILLER-DIEKER LISSENCEPHALY SYNDROME; MDLS TRANSLOCATED CHROMOSOME
MUCOPOLYSACCHARIDOSIS TYPE IIIA N-SULFOGLUCOSAMINE SULFOHYDROLASE; SGSH
LEBER OPTIC ATROPHY COMPLEX I, SUBUNIT ND4; MTND4
ENDOGLIN; ENG TELANGIECTASIA, HEREDITARY HEMORRHAGIC, OF RENDU, OSLER, AND WEBER; HHT
MARFAN SYNDROME; MFS APPARENTLY HEALTHY NON-FETAL TISSUE
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 CEPH/UTAH PEDIGREE 1332 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 CEPH/UTAH PEDIGREE 1344
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1350 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1344 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24
CEPH/UTAH PEDIGREE 1346 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 CEPH/UTAH PEDIGREE 1349 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1349
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1420 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1420
CEPH/UTAH PEDIGREE 1424 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 CEPH/UTAH PEDIGREE 1424
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 CEPH/UTAH PEDIGREE 1423
CEPH/UTAH PEDIGREE 1423 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1; UGT1A1
ADENINE PHOSPHORIBOSYLTRANSFERASE; APRT 2,8-@DIHYDROXYADENINE UROLITHIASIS, INCLUDED
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 CEPH/UTAH PEDIGREE 1408 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1408 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 SNP500 PANEL CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1416 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1347 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] SNP500 PANEL
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 SNP500 PANEL CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CEPH/UTAH PEDIGREE 1347
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] SNP500 PANEL CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1362
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1362 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 SNP500 PANEL
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1346
BOVINE PORPHYRIA, CONGENITAL ERYTHROPOIETIC BOS
CHROMOSOME DELETION RETINOBLASTOMA, SPORADIC
CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 15 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
GREIG CEPHALOPOLYSYNDACTYLY SYNDROME; GCPS CHROMOSOME DELETION
CHROMOSOME DELETION TRANSLOCATED CHROMOSOME
CEROID LIPOFUSCINOSIS, NEURONAL 2, LATE INFANTILE TYPE; CLN2
TRANSLOCATED CHROMOSOME KALLMANN SYN; HYPOGONADOTROPIC HYPOGONADISM, ANOSMIA- 147950, 244200, 308700
ADDITIONAL HUMAN/CHINESE HAMSTER SOMATIC CELL HYBRIDS CHROMOSOME 12 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
THANATOPHORIC DYSPLASIA WITH KLEEBLATTSCHAEDEL
OSTEOCHONDRODYSPLASIA WITH RHIZOMELIA & OTHER FEATURES - UNKNOWN INHERITANCE
CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 10 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 15 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
TRANSLOCATED CHROMOSOME APPARENTLY HEALTHY NON-FETAL TISSUE
donor subject is homozygous for a deletion of exons 7 and 8 in the SMN1 gene and has 2 copies of the SMN2 gene
MYOTUBULARIN; MTM1 MYOTUBULAR MYOPATHY 1; MTM1
FIBROBLAST GROWTH FACTOR RECEPTOR 3; FGFR3 INVERTED CHROMOSOME THANATOPHORIC DYSPLASIA; TD
CHROMOSOME INSERTION RETINOBLASTOMA, SPORADIC
MONOZYGOTIC TWIN PAIRS APPARENTLY HEALTHY FETAL TISSUE
INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE II)
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE II) INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA
INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE I) INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I)
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA
KARTAGENER SYNDROME STARGARDT DISEASE 1; STGD1
INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE II)
HUMAN ERYTHROLEUKEMIC CELL LINES CHRONIC MYELOGENOUS LEUKEMIA
INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE I) INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE I)
INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE II) INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA
INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - YORUBA IN IBADAN, NIGERIA (PLATE I)
INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I)
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
INTERNATIONAL HAPMAP PROJECT - HAN CHINESE IN BEIJING, CHINA CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I)
HEXOSAMINIDASE A; HEXA CANAVAN DISEASE ASPARTOACYLASE; ASPA
METACHROMATIC LEUKODYSTROPHY, LATE-INFANTILE
METHYLMALONICACIDURIA DUE TO METHYLMALONIC COA MUTASE DEFICIENCY
MYOPATHY WITH GIANT ABNORMAL MITOCHONDRIA
CHARCOT-MARIE-TOOTH DISEASE, TYPE 1A; CMT1A
CHARCOT-MARIE-TOOTH DISEASE, TYPE 1A; CMT1A PERIPHERAL MYELIN PROTEIN 22; PMP22
MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD APPARENTLY HEALTHY NON-FETAL TISSUE
APPARENTLY HEALTHY NON-FETAL TISSUE MAPLE SYRUP URINE DISEASE (MSUD), TYPE IA
LPC-1021
only one copy of the SMN2 gene; homozygous for deletion of exons 7 and 8 of the SMN1 gene
GM-232
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC XXXY AND XXXXY SYNDROME
OROTICACIDURIA TYPES I OR II - 258900 OR 258920
DICENTRIC CHROMOSOME ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
METHYLMALONICACIDURIA, VITAMIN B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN--CBL A
TRISOMY 21 ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
MACROCEPHALY, MULTIPLE LIPOMAS, AND HEMANGIOMATA
BETA GLOBIN REGION RESTRICTION POLYMORPHISMS
BETA GLOBIN REGION RESTRICTION POLYMORPHISMS APPARENTLY HEALTHY NON-FETAL TISSUE
APPARENTLY HEALTHY NON-FETAL TISSUE BETA GLOBIN REGION RESTRICTION POLYMORPHISMS
PSEUDOXANTHOMA ELASTICUM, AUTOSOMAL RECESSIVE; PXE ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 6; ABCC6
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC XXXXX SYNDROME
HARTNUP DISORDER SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER), MEMBER 19; SLC6A19
INTERNATIONAL HAPMAP PROJECT - LUHYA FROM WEBUYE, KENYA INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 LUHYA FROM WEBUYE, KENYA
INTERNATIONAL HAPMAP PROJECT - LUHYA FROM WEBUYE, KENYA
CALCINOSIS, TUMORAL, WITH HYPERPHOSPHATEMIA
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I)
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE II) INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I)
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE II)
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I)
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9
GLUCOSIDASE, ACID BETA; GBA TAY-SACHS DISEASE; TSD HEXOSAMINIDASE A; HEXA
INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 LUHYA FROM WEBUYE, KENYA INTERNATIONAL HAPMAP PROJECT - LUHYA FROM WEBUYE, KENYA
SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1; SGBS1 TRANSLOCATED CHROMOSOME
MUCOLIPIDOSIS IIIA N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE, ALPHA/BETA SUBUNITS; GNPTAB
APPARENTLY HEALTHY NON-FETAL TISSUE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR
MUCOPOLYSACCHARIDOSIS TYPE IIIB N-ACETYLGLUCOSAMINIDASE, ALPHA-; NAGLU
TRANSLOCATED CHROMOSOME XXXY AND XXXXY SYNDROME
FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; FOP
APPARENTLY HEALTHY AMNIOTIC FLUID CELL CULTURE
HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2) CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR CYSTIC FIBROSIS; CF
GLYCOGEN STORAGE DISEASE VIII (IX, INCLUDED)
ACYL-CoA DEHYDROGENASE, MEDIUM-CHAIN, DEFICIENCY OF
ADRENOLEUKODYSTROPHY, AUTOSOMAL NEONATAL FORM PEROXISOME BIOGENESIS FACTOR 26; PEX26
APPARENTLY HEALTHY NON-FETAL TISSUE GALACTOSEMIA
TRANSLOCATED CHROMOSOME GALACTOSEMIA GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; GALT
INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO, JAPAN INTERNATIONAL HAPMAP PROJECT - JAPANESE IN TOKYO AND HAN CHINESE IN BEIJING (PLATE I) CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9
HYPOCHONDROPLASIA; HCH FIBROBLAST GROWTH FACTOR RECEPTOR 3; FGFR3
CYSTIC FIBROSIS; CF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2)
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR CYSTIC FIBROSIS; CF HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2)
CYSTINOSIN; CTNS CYSTINOSIS, LATE-ONSET JUVENILE OR ADOLESCENT NEPHROPATHIC TYPE
CYSTINOSIS, LATE-ONSET JUVENILE OR ADOLESCENT NEPHROPATHIC TYPE CYSTINOSIN; CTNS
LEUKEMIA, SUB-ACUTE TRANSLOCATED CHROMOSOME
PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES LEUCINE-RICH REPEAT KINASE2; LRRK2 PARKINSON'S DISEASE
ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL SPOUSAL CONTROL
PARKINSON'S DISEASE RESTLESS LEG SYNDROME YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS
DNA POLYMORPHISM DISCOVERY RESOURCE COLLECTION
NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL SPOUSAL CONTROL
NEUROFIBROMATOSIS, TYPE I; NF1 APPARENTLY HEALTHY NON-FETAL TISSUE
AT RISK ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
ESSENTIAL TREMOR-MOVEMENT DISORDER ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
donor subject has 2 copies of the SMN2 gene and is homozygous for deletion of exons 7 and 8 of the SMN1 gene
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 DNA POLYMORPHISM DISCOVERY RESOURCE COLLECTION
EHLERS-DANLOS SYNDROME, TYPE III GLYCOGEN STORAGE DISEASE VIII (IX, INCLUDED)
EHLERS-DANLOS SYNDROME, TYPE III APPARENTLY HEALTHY NON-FETAL TISSUE GLYCOGEN STORAGE DISEASE VIII (IX, INCLUDED)
APPARENTLY HEALTHY NON-FETAL TISSUE EHLERS-DANLOS SYNDROME, TYPE III GLYCOGEN STORAGE DISEASE VIII (IX, INCLUDED)
INTERNATIONAL HAPMAP PROJECT - COMMUNITIES OF MEXICAN ORIGIN IN LOS ANGELES, CA INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 FROM COMMUNITIES OF MEXICAN ORIGIN IN LOS ANGELES, CA
INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 FROM COMMUNITIES OF MEXICAN ORIGIN IN LOS ANGELES, CA INTERNATIONAL HAPMAP PROJECT - COMMUNITIES OF MEXICAN ORIGIN IN LOS ANGELES, CA
GLYCOGEN STORAGE DISEASE VIII (IX, INCLUDED) EHLERS-DANLOS SYNDROME, TYPE III
INTERNATIONAL HAPMAP PROJECT - AFRICAN ANCESTRY FROM THE SW USA INTERNATIONAL HAPMAP PROJECT - PLATE OF AFRICAN ANCESTRY FROM THE SW USA
INTERNATIONAL HAPMAP PROJECT - PLATE OF AFRICAN ANCESTRY FROM THE SW USA INTERNATIONAL HAPMAP PROJECT - AFRICAN ANCESTRY FROM THE SW USA
DNA POLYMORPHISM DISCOVERY RESOURCE COLLECTION CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9
PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS RESTLESS LEG SYNDROME REM BEHAVIOR DISORDER
PROGRESSIVE SUPRANUCLEAR PALSY PARKINSON'S DISEASE
SCHIZOPHRENIA ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
DEMENTIA WITH LEWY BODIES PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES PARKINSON'S DISEASE
ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL SPASMODIC TORTICOLLIS-CERVICAL DYSTONIA
YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS PARKINSON'S DISEASE DEMENTIA WITH LEWY BODIES
YOUNG ONSET PARKINSON'S DISEASE; AFFECTED INDIVIDUALS RESTLESS LEG SYNDROME DEMENTIA WITH LEWY BODIES PARKINSON'S DISEASE
PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL POPULATION/CONVENIENCE CONTROL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL SPOUSAL CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL
CHROMOSOME 10 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 7 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 7 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 6 SOMATIC CELL HYBRIDS
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NDPT031- AFRICAN AMERICAN CONTROL PANEL POPULATION/CONVENIENCE CONTROL
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 3 SOMATIC CELL HYBRIDS CHROMOSOME 7 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 6 SOMATIC CELL HYBRIDS CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 7 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 6 SOMATIC CELL HYBRIDS
YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS ESSENTIAL TREMOR-MOVEMENT DISORDER PARKINSON'S DISEASE
CZECHOSLOVAKIAN POPULATION HUMAN VARIATION PANEL - CZECHOSLOVAKIAN
HUMAN VARIATION PANEL - CZECHOSLOVAKIAN CZECHOSLOVAKIAN POPULATION
TRICHOTHIODYSTROPHY; TTD ICHTHYOSIFORM ERYTHRODERMA WITH HAIR ABNORMALITY AND MENTAL AND GROWTH RETARDATION, INCLUDED EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 2; ERCC2
EXCISION-REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 2; ERCC2 TRICHOTHIODYSTROPHY; TTD ICHTHYOSIFORM ERYTHRODERMA WITH HAIR ABNORMALITY AND MENTAL AND GROWTH RETARDATION, INCLUDED
ICELANDIC POPULATION HUMAN VARIATION PANEL - ICELAND
HUMAN VARIATION PANEL - ICELAND ICELANDIC POPULATION
CHROMOSOME 10 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 3 SOMATIC CELL HYBRIDS
SYNUCLEIN, ALPHA; SNCA PARKINSON DISEASE,FAMILIAL, TYPE 1; PARK1
NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 POPULATION/CONVENIENCE CONTROL
GLUCOSIDASE, ACID BETA; GBA GAUCHER DISEASE, TYPE III
HYDROXYACYL-CoA DEHYDROGENASE/3-KETOACYL-CoA THIOLASE/ENOYL-CoA HYDRATASE, ALPHA SUBUNIT; HADHA LONG-CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY
HYDROXYACYL-CoA DEHYDROGENASE/3-KETOACYL-CoA THIOLASE/ENOYL-CoA HYDRATASE, BETA SUBUNIT; HADHB TRIFUNCTIONAL PROTEIN DEFICIENCY
TRANSLOCATED CHROMOSOME NON-HODGKINS LYMPHOMA
PHOSPHATE-REGULATING ENDOPEPTIDASE HOMOLOG; X-LINKED; PHEX HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT
HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT
METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblC TYPE
MARVEL DOMAIN-CONTAINING PROTEIN 2; MARVELD2 DEAFNESS, AUTOSOMAL RECESSIVE 49; DFNB49
DEAFNESS, AUTOSOMAL RECESSIVE 49; DFNB49 MARVEL DOMAIN-CONTAINING PROTEIN 2; MARVELD2
DEAFNESS, AUTOSOMAL RECESSIVE 28; DFNB28 TRIO- AND F-ACTIN-BINDING PROTEIN; TRIOBP
TRIO- AND F-ACTIN-BINDING PROTEIN; TRIOBP DEAFNESS, AUTOSOMAL RECESSIVE 28; DFNB28
SHORT STATURE HOMEOBOX; SHOX LANGER MESOMELIC DYSPLASIA
LANGER MESOMELIC DYSPLASIA SHORT STATURE HOMEOBOX; SHOX
ISODICENTRIC CHROMOSOME AUTISTIC DISORDER
AUTISTIC DISORDER ISODICENTRIC CHROMOSOME
PARKIN; PARK2 PARKINSON DISEASE, JUVENILE, AUTOSOMAL RECESSIVE; PDJ PARKINSON'S DISEASE
ADDITIONAL DELETION/DERIVATIVE Y CHROMOSOME SOMATIC CELL HYBRIDS CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2D; CMT2D GLYCYL-TRNA SYNTHETASE; GARS
NEUROFIBROMATOSIS, TYPE II; NF2 NEUROFIBROMIN 2; NF2
DERIVATIVE CHROMOSOME DUPLICATED CHROMOSOME
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC DUPLICATED CHROMOSOME DERIVATIVE CHROMOSOME
CHROMOSOME DELETION DUPLICATED CHROMOSOME DERIVATIVE CHROMOSOME
DUPLICATED CHROMOSOME ENCEPHALOPATHY OF CHILDHOOD (LENNOX-GASTAUT SYNDROME)
EUKARYOTIC TRANSLATION INITIATION FACTOR 2B, SUBUNIT 2; EIF2B2 LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER; VWM (OVARIOLEUKODYSTROPHY, INCLUDED)
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ig DOLICHYL-P-MANNOSE:MAN-7-GlcNAc-2-PP-DOLICHYL-ALPHA-6-MANNOSYLTRANSFERASE
CORNELIA DE LANGE SYNDROME 1; CDLS1 NIPPED-B-LIKE; NIPBL
SOTOS SYNDROME NUCLEAR RECEPTOR-BINDING Su-var, ENHANCER OF ZESTE, AND TRITHORAX DOMAIN PROTEIN 1; NSD1
PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S DNA PANEL; AFFECTED INDIVIDUALS ESSENTIAL TREMOR-MOVEMENT DISORDER
POPULATION/CONVENIENCE CONTROL CONTROL PANEL FOR YOUNG ONSET PARKINSON'S; UNAFFECTED INDIVIDUALS RESTLESS LEG SYNDROME
ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES
FAMILIAL MULTIPLE CONGENITAL ANOMALIES - UNKNOWN SYNDROME OR INHERITANCE
MUSCULAR DYSTROPHY, PROGRESSIVE WITH CNS INVOLVEMENT & RECESSIVE INHERITANCE
INVERTED CHROMOSOME CRYPTOPHTHALMOS WITH OTHER MALFORMATIONS
CRYPTOPHTHALMOS WITH OTHER MALFORMATIONS
DIGEORGE SYNDROME; DGS CHROMOSOME DELETION
CONGENITAL HEART DISEASE; TRUNCUS ARTERIOSUS
CONGENITAL HEART DISEASE; TRANSPOSITION OF GREAT VESSELS
AMYOTROPHIC LATERAL SCLEROSIS ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
TURNER SYNDROME INVERTED CHROMOSOME ISODICENTRIC CHROMOSOME
EXCISION-REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 6; ERCC6 COCKAYNE SYNDROME, TYPE B, INCLUDED; CSB, INCLUDED
ALPHA-L-IDURONIDASE; IDUA HURLER SYNDROME
BRANCHED-CHAIN KETO ACID DEHYDROGENASE E1, ALPHA POLYPEPTIDE; BCKDHA MAPLE SYRUP URINE DISEASE (MSUD), TYPE IA
INTERNATIONAL HAPMAP PROJECT - TOSCANI IN ITALIA (TUSCANS IN ITALY) INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 TOSCANI IN ITALIA (TUSCANS IN ITALY)
ARH GENE; ARH HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE; ARH
INTERNATIONAL HAPMAP PROJECT - PANEL OF 90 TOSCANI IN ITALIA (TUSCANS IN ITALY) INTERNATIONAL HAPMAP PROJECT - TOSCANI IN ITALIA (TUSCANS IN ITALY)
INTERNATIONAL HAPMAP PROJECT - TOSCANI IN ITALIA (TUSCANS IN ITALY)
MAPLE SYRUP URINE DISEASE (MSUD), TYPE II DIHYDROLIPOAMIDE BRANCHED-CHAIN TRANSACYLASE; DBT
RETINOIC ACID-INDUCED GENE 1; RAI1 SMITH-MAGENIS SYNDROME; SMS
5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR FACTOR V DEFICIENCY
SPONDYLOEPIMETAPHYSEAL DYSPLASIA WITH MULTIPLE DISLOCATIONS
SMITH-MAGENIS SYNDROME; SMS RETINOIC ACID-INDUCED GENE 1; RAI1
5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR
CHROMOSOME DELETION SMITH-MAGENIS SYNDROME; SMS
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS
HOLOCARBOXYLASE SYNTHETASE DEFICIENCY HOLOCARBOXYLASE SYNTHETASE; HLCS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE US
APPARENTLY HEALTHY NON-FETAL TISSUE EPIDERMOLYSIS BULLOSA: DYSTROPHIC, JUNCTIONAL, OR SIMPLEX TYPES
ALS PANEL; GREATER THAN 7 YEARS SURVIVAL ALS PANEL CAUCASIAN FROM THE UNITED STATES AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE UNITED STATES
ALS PANEL CAUCASIAN FROM THE US ALS PANEL CAUCASIAN FROM THE UNITED STATES AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE UNITED STATES
CARNITINE-ACYLCARNITINE TRANSLOCASE; CACT
ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
SH2 DOMAIN PROTEIN 1A; SH2D1A LYMPHOPROLIFERATIVE SYNDROME, X-LINKED
TRANSLOCATED CHROMOSOME ANIRIDIA: TYPES 1 OR 2 - 106200 OR 106210
SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED; SCIDX1
ANIRIDIA: TYPES 1 OR 2 - 106200 OR 106210
ANIRIDIA: TYPES 1 OR 2 - 106200 OR 106210 TRANSLOCATED CHROMOSOME
CORNELIA DE LANGE SYNDROME 1; CDLS1 TRANSLOCATED CHROMOSOME
SPECIFIC ANTIBODY DEFICIENCY WITH NORMAL IMMUNOGLOBULINS AND PEG-TEETH
TELANGIECTASIA, HEREDITARY HEMORRHAGIC, OF RENDU, OSLER, AND WEBER; HHT ENDOGLIN; ENG
WISKOTT-ALDRICH SYNDROME; WAS WAS GENE; WAS
TRANSLOCATED CHROMOSOME CORNELIA DE LANGE SYNDROME 1; CDLS1
IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 1; HIGM1 CD40 LIGAND; CD40LG
IMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST
TRANSLOCATED CHROMOSOME OROFACIAL CLEFT 1; OFC1
TURNER SYNDROME ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
CHROMOSOME DELETION ANGELMAN SYNDROME; AS
ESTABLISHMENT OF COHESION 1, S. CERVISIAE, HOMOLOG OF, 2; ESCO2 SC PHOCOMELIA SYNDROME
ANGELMAN SYNDROME; AS COMPLETE PATERNAL UNIPARENTAL DISOMY
PRADER-WILLI SYNDROME; PWS COMPLETE MATERNAL UNIPARENTAL DISOMY
HEMOGLOBIN--DELTA LOCUS; HBD HEMOGLOBIN--BETA LOCUS; HBB
PORPHYRIA, ACUTE INTERMITTENT APPARENTLY HEALTHY NON-FETAL TISSUE
APPARENTLY HEALTHY NON-FETAL TISSUE MUCOPOLYSACCHARIDOSIS TYPE VI
CEROID LIPOFUSCINOSIS, NEURONAL 3, JUVENILE; CLN3 CLN3 GENE; CLN3
METHIONINE ADENOSYLTRANSFERASE DEFICIENCY
ALPERS DIFFUSE DEGENERATION OF CEREBRAL GRAY MATTER WITH HEPATIC CIRRHOSIS POLYMERASE, DNA, GAMMA; POLG
POLYMERASE, DNA, GAMMA; POLG ALPERS DIFFUSE DEGENERATION OF CEREBRAL GRAY MATTER WITH HEPATIC CIRRHOSIS
TRANSLOCATED CHROMOSOME ACUTE LYMPHOCYTIC LEUKEMIA
TRANSLOCATED CHROMOSOME DERIVATIVE CHROMOSOME ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
CYSTINOSIS, LATE-ONSET JUVENILE OR ADOLESCENT NEPHROPATHIC TYPE
METHYLMALONICACIDURIA, VITAMIN B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN--CBL B
GAUCHER DISEASE, TYPE III GLUCOSIDASE, ACID BETA; GBA
ADDITIONAL DELETION/DERIVATIVE Y CHROMOSOME SOMATIC CELL HYBRIDS CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
MUSCULAR DYSTROPHY, PSEUDOHYPERTROPHIC PROGRESSIVE, DUCHENNE AND BECKER TYPES; DMD TRANSLOCATED CHROMOSOME
ANIRIDIA, GENITOURINARY ABNORMALITIES, & VASCULITIS
TRANSLOCATED CHROMOSOME RETINOBLASTOMA, SPORADIC
LEUCINE-RICH REPEAT KINASE2; LRRK2 PARKINSON'S DISEASE
MULTIPLE SYSTEM ATROPHY PARKINSON'S DISEASE PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 14 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 11 SOMATIC CELL HYBRIDS
PARKINSON'S DISEASE PAROXYSMAL EXERCISE INDUCED DYSTONIA
TRANSLOCATED CHROMOSOME HOLOPROSENCEPHALY
DEMENTIA WITH LEWY BODIES PARKINSON'S DISEASE
ULCERATIVE COLITIS, SUSCEPTIBILITY TO SPECIFIC ANTIBODY DEFICIENCY WITH NORMAL IMMUNOGLOBULINS
REM BEHAVIOR DISORDER PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S DISEASE; AFFECTED INDIVIDUALS
RETINOBLASTOMA; RB1 OSTEOSARCOMA, RETINOBLASTOMA-RELATED, INCLUDED MONOZYGOTIC TWIN PAIRS
MONOZYGOTIC TWIN PAIRS RETINOBLASTOMA; RB1 OSTEOSARCOMA, RETINOBLASTOMA-RELATED, INCLUDED
N-SULFOGLUCOSAMINE SULFOHYDROLASE; SGSH MUCOPOLYSACCHARIDOSIS TYPE IIIA
BIOCHEMICAL MARKERS GLUCOSE-6-PHOSPHATE DEHYDROGENASE; G6PD
GLUCOSE-6-PHOSPHATE DEHYDROGENASE; G6PD BIOCHEMICAL MARKERS
GALACTOSEMIA GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; GALT MONOZYGOTIC TWIN PAIRS
DIABETES MELLITUS: MATURITY ONSET DIABETES - 222100 OR 125850
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 16 SOMATIC CELL HYBRIDS CHROMOSOME 11 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
FAMILIAL MEDITERRANEAN FEVER GENE; MEFV MEDITERRANEAN FEVER, FAMILIAL; MEFV
PARKINSON DISEASE,FAMILIAL, TYPE 1; PARK1 SYNUCLEIN, ALPHA; SNCA
RESTLESS LEG SYNDROME PARKINSON'S DISEASE PARKINSONS PANEL: CAUCASIAN FROM THE UNITED STATES
YOUNG ONSET PARKINSON'S DISEASE; AFFECTED INDIVIDUALS RESTLESS LEG SYNDROME PARKINSON'S DISEASE
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 6 SOMATIC CELL HYBRIDS CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
THROMBOCYTOPENIA ACUTE LYMPHOCYTIC LEUKEMIA
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 16 SOMATIC CELL HYBRIDS CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 16 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 6 SOMATIC CELL HYBRIDS
CHROMOSOME 12 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 16 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3 HIRSCHSPRUNG DISEASE
APPARENTLY HEALTHY NON-FETAL TISSUE NON-OBESE CONTROLS
NON-OBESE CONTROLS APPARENTLY HEALTHY NON-FETAL TISSUE
TAY-SACHS DISEASE; TSD ASPARTOACYLASE; ASPA HEXOSAMINIDASE A; HEXA
ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL ESSENTIAL TREMOR-MOVEMENT DISORDER
CHROMOSOME DELETION TRICHORHINOPHALANGEAL SYNDROME, TYPE II; TRPS2 (LANGER-GIEDION SYNDROME; LGS)
PERIODIC LIMB MOVEMENT DISORDER ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL RESTLESS LEG SYNDROME
FOCAL DYSTONIA ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
CHROMOSOME INSERTION BASAL CELL NEVUS SYNDROME; BCNS
RESTLESS LEG SYNDROME PERIODIC LIMB MOVEMENT DISORDER ASYMPTOMATIC AND GENETICALLY RELATED TO AN AFFECTED INDIVIDUAL
PARKINSON'S DISEASE YOUNG ONSET PARKINSON'S PANEL; AFFECTED INDIVIDUALS SPASMODIC TORTICOLLIS-CERVICAL DYSTONIA
INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP ASPARTOACYLASE; ASPA NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3
PROGRESSIVE SUPRANUCLEAR PALSY PARKINSON'S DISEASE LATE ONSET PARKINSON'S DNA PANEL, AFFECTED INDIVIDUALS
PARKINSON DISEASE,FAMILIAL, TYPE 1; PARK1 DEMENTIA WITH LEWY BODIES SYNUCLEIN, ALPHA; SNCA PARKINSON'S DISEASE
ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC XXXX SYNDROME
DNA DAMAGE-BINDING PROTEIN 2; DDB2 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E
APPARENTLY HEALTHY NON-FETAL TISSUE HYPERCHOLESTEROLEMIA, FAMILIAL; FHC
POPULATION/CONVENIENCE CONTROL POPULATION/CONVENIENCE CONTROL
HEMOGLOBIN F, HEREDITARY PERSISTENCE OF, PANCELLULAR
PARKINSON'S DISEASE SYNUCLEIN, ALPHA; SNCA PARKINSON DISEASE,FAMILIAL, TYPE 1; PARK1
HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT LOW DENSITY LIPOPROTEIN RECEPTOR; LDLR
LOW DENSITY LIPOPROTEIN RECEPTOR; LDLR HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT
ALPHA-L-IDURONIDASE; IDUA SCHEIE SYNDROME
MAPLE SYRUP URINE DISEASE (MSUD), TYPE IA BRANCHED-CHAIN KETO ACID DEHYDROGENASE E1, ALPHA POLYPEPTIDE; BCKDHA
CARNITINE PALMITOYLTRANSFERASE II DEFICIENCY, LATE-ONSET CARNITINE PALMITOYLTRANSFERASE II; CPT2
DYGGVE-MELCHIOR-CLAUSEN DISEASE DYMECLIN; DYM
BULBAR PALSY, PROGRESSIVE, WITH SENSORINEURAL DEAFNESS
APPARENTLY HEALTHY NON-FETAL TISSUE AZOOSPERMIA FACTOR C
AZOOSPERMIA FACTOR C APPARENTLY HEALTHY NON-FETAL TISSUE
SMITH-MAGENIS SYNDROME; SMS CHROMOSOME DELETION
PSEUDOTRISOMY 13 SYNDROME (HOLOPROSENCEPHALY-POLYDACTYLY SYNDROME)
SH3 DOMAIN-BINDING PROTEIN 2; SH3BP2 CHERUBISM
ATAXIA-TELANGIECTASIA AND RAD3-RELATED; ATR SECKEL SYNDROME
NPC2 GENE; NPC2 NIEMANN-PICK DISEASE, TYPE C2
APPARENTLY HEALTHY NON-FETAL TISSUE NON-OBESE CONTROLS MONOZYGOTIC TWIN PAIRS
MONOZYGOTIC TWIN PAIRS APPARENTLY HEALTHY NON-FETAL TISSUE NON-OBESE CONTROLS
CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 6 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 22 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
NON-OBESE CONTROLS MONOZYGOTIC TWIN PAIRS APPARENTLY HEALTHY NON-FETAL TISSUE
MONOZYGOTIC TWIN PAIRS NON-OBESE CONTROLS APPARENTLY HEALTHY NON-FETAL TISSUE
NON-OBESE CONTROLS APPARENTLY HEALTHY NON-FETAL TISSUE MONOZYGOTIC TWIN PAIRS
APPARENTLY HEALTHY NON-FETAL TISSUE MONOZYGOTIC TWIN PAIRS NON-OBESE CONTROLS
MONOZYGOTIC TWIN PAIRS APPARENTLY HEALTHY NON-FETAL TISSUE
NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: YOUNG AND AGED FOR EACH SPECIES REPRESENTED MACACA ORDER: PRIMATES
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G; XPG NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
PRESENILIN 1; PSEN1 ALZHEIMER DISEASE, FAMILIAL, TYPE 3
ALZHEIMER DISEASE; AD APOLIPOPROTEIN E; APOE NIA AGING CELL REPOSITORY DNA PANEL - EARLY ONSET FAMILIAL ALZHEIMER DISEASE
GALACTOSEMIA GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; GALT TRANSLOCATED CHROMOSOME
CYSTIC FIBROSIS; CF HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2) CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR
ATAXIA-TELANGIECTASIA; AT TRANSLOCATED CHROMOSOME ATAXIA-TELANGIECTASIA MUTATED GENE; ATM
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E
GANGLIOSIDOSIS, GENERALIZED GM1, TYPE I MUCOPOLYSACCHARIDOSIS TYPE IVB
CHROMOSOME 18 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME X REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1; ENPP1
HEMOCHROMATOSIS; HFE FACTOR V DEFICIENCY
BREAST CANCER, TYPE 1; BRCA1 BREAST CANCER INFORMATION CORE (BIC) BRCA1/BRCA2 MUTATION PANEL DNA SAMPLES
BREAST CANCER INFORMATION CORE (BIC) BRCA1/BRCA2 MUTATION PANEL DNA SAMPLES BREAST CANCER 2, EARLY-ONSET; BRCA2
FACTOR V DEFICIENCY HEMOCHROMATOSIS; HFE HUMAN GENE MUTATION PANEL - HEMOCHROMATOSIS
HUMAN GENE MUTATION PANEL - HEMOCHROMATOSIS HEMOCHROMATOSIS; HFE
BREAST CANCER 2, EARLY-ONSET; BRCA2 BREAST CANCER INFORMATION CORE (BIC) BRCA1/BRCA2 MUTATION PANEL DNA SAMPLES
ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS
ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
APPARENTLY HEALTHY NON-FETAL TISSUE ANEUPLOID CHROMOSOME NUMBER - NON-TRISOMIC
ALS PANEL CAUCASIAN FROM THE US ALS PANEL; GREATER THAN 7 YEARS SURVIVAL AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
POLYDACTYLY WITH NEONATAL CHONDRODYSTROPHY, TYPE II, MAJEWSKI TYPE
CHROMOSOME 2 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 11 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 12 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ECTODERMAL DYSPLASIA, TYPE 4; ED4 POLIOVIRUS RECEPTOR-LIKE 1; PVRL1
CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 17 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
CHROMOSOME 1 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE X CHROMOSOME SOMATIC CELL HYBRIDS
ALS PANEL CAUCASIAN FROM THE US ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
PROTEASE INHIBITOR 1; PI HEMOCHROMATOSIS; HFE
HUMAN GENE MUTATION PANEL - DISORDERS OF THROMBOSIS FACTOR V DEFICIENCY
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; GREATER THAN 7 YEARS SURVIVAL
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS
MENKES SYNDROME ATPASE, CU(2+)-TRANSPORTING, ALPHA POLYPEPTIDE; ATP7A
TOCOPHEROL TRANSFER PROTEIN, ALPHA; TTPA VITAMIN E, FAMILIAL ISOLATED DEFICIENCY OF; VED
ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE US
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE US
MUCOPOLYSACCHARIDOSIS TYPE IIIA TRANSLOCATED CHROMOSOME N-SULFOGLUCOSAMINE SULFOHYDROLASE; SGSH
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; GREATER THAN 7 YEARS SURVIVAL
NDPT031- AFRICAN AMERICAN CONTROL PANEL SPOUSAL CONTROL
ANEUPLOID CHROMOSOME NUMBER - TRISOMY ANEUPLOID CHROMOSOME NUMBER - TRISOMY 8
TRANSLOCATED CHROMOSOME XX MALE SYNDROME DERIVATIVE CHROMOSOME
ATPASE, CU(2+)-TRANSPORTING, ALPHA POLYPEPTIDE; ATP7A MENKES SYNDROME
BREAST CANCER INFORMATION CORE (BIC) BRCA1/BRCA2 MUTATION PANEL DNA SAMPLES BREAST CANCER, TYPE 1; BRCA1
DRPLA GENE; DRPLA DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY; DRPLA
DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY; DRPLA DRPLA GENE; DRPLA
ATAYAL POPULATION HUMAN VARIATION PANEL - ABORIGINAL TRIBE FROM TAIWAN (ATAYAL)
HUMAN GENE MUTATION PANEL - HEMOCHROMATOSIS CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR HUMAN GENE MUTATION PANEL - CYSTIC FIBROSIS (VERSION 2) CYSTIC FIBROSIS; CF HEMOCHROMATOSIS; HFE 5,10-@METHYLENETETRAHYDROFOLATE REDUCTASE; MTHFR
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL CAUCASIAN FROM THE UNITED STATES
ALS PANEL CAUCASIAN FROM THE UNITED STATES ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; GREATER THAN 7 YEARS SURVIVAL
ADYGEI POPULATION HUMAN VARIATION PANEL - RUSSIAN (KRASNODAR IN SOUTHEAST EUROPEAN RUSSIA)
ADYGEI POPULATION SNP500 PANEL HUMAN VARIATION PANEL - RUSSIAN (KRASNODAR IN SOUTHEAST EUROPEAN RUSSIA)
SNP500 PANEL ADYGEI POPULATION HUMAN VARIATION PANEL - RUSSIAN (KRASNODAR IN SOUTHEAST EUROPEAN RUSSIA)
AMI POPULATION HUMAN VARIATION PANEL - ABORIGINAL TRIBE FROM TAIWAN (AMI)
SNP500 PANEL AMI POPULATION HUMAN VARIATION PANEL - ABORIGINAL TRIBE FROM TAIWAN (AMI)
AMI POPULATION SNP500 PANEL HUMAN VARIATION PANEL - ABORIGINAL TRIBE FROM TAIWAN (AMI)
AMI POPULATION HUMAN VARIATION PANEL - ABORIGINAL TRIBE FROM TAIWAN (AMI) SNP500 PANEL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL POPULATION/CONVENIENCE CONTROL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008
APPARENTLY HEALTHY AMNIOTIC FLUID CELL CULTURE CHROMOSOME DELETION
COFFIN-LOWRY SYNDROME; CLS INVERTED CHROMOSOME
TAY-SACHS DISEASE; TSD HEXOSAMINIDASE A; HEXA ASPARTOACYLASE; ASPA
X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 9; XRCC9 FANCONI ANEMIA, COMPLEMENTATION GROUP G; FANCG
ASPARTOACYLASE; ASPA INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE-COMPLEX ASSOCIATED PROTEIN; IKBKAP NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE III; HSAN3
RUSSIAN POPULATION HUMAN VARIATION PANEL - RUSSIAN (ZVERSKY DISTRICT NORTHEAST OF MOSCOW)
GANGLIOSIDOSIS, GENERALIZED GM1, TYPE II, OR JUVENILE TYPE
MUCOLIPIN 1; MCOLN1 GLUCOSIDASE, ACID BETA; GBA MUCOLIPIDOSIS IV
OXALOSIS TYPES I OR II, GLYCOLIC OR GLYCERIC ACIDURIA - 259900 OR 260000
MACACA ORDER: PRIMATES NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: YOUNG AND AGED FOR EACH SPECIES REPRESENTED
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008 NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL SPOUSAL CONTROL
HUMAN VARIATION PANEL - RUSSIAN (ZVERSKY DISTRICT NORTHEAST OF MOSCOW) RUSSIAN POPULATION
CHROMOSOME 8 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 21 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
NEMALINE MYOPATHY, AMISH TYPE; ANM TROPONIN T1, SKELETAL, SLOW; TNNT1
DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY; DRPLA
CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC 1; PFIC1 NEMALINE MYOPATHY 2, AUTOSOMAL RECESSIVE; NEM2
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 13 SOMATIC CELL HYBRIDS
PARKINSONISM, OTHER AMYOTROPHIC LATERAL SCLEROSIS
CORNELIA DE LANGE SYNDROME 1; CDLS1 MONOZYGOTIC TWIN PAIRS
CLEFT LIP WITH OR WITHOUT CLEFT PALATE, POSSIBLY SYNDROMIC
LOW-GGT PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS (NOT FURTHER CHARACTERIZED)
NIA AGING CELL REPOSITORY DNA PANEL - LATE ONSET FAMILIAL ALZHEIMER DISEASE APOLIPOPROTEIN E; APOE ALZHEIMER DISEASE; AD
KALLMANN SYN; HYPOGONADOTROPIC HYPOGONADISM, ANOSMIA- 147950, 244200, 308700
NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: PHYLOGENETIC ORDER: PRIMATES MACACA
CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 9 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 4 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 5 SOMATIC CELL HYBRIDS
CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 18 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 7 SOMATIC CELL HYBRIDS CHROMOSOME 18 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 5 SOMATIC CELL HYBRIDS ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 4 SOMATIC CELL HYBRIDS
ADDITIONAL DELETION/DERIVATIVE CHROMOSOME 4 SOMATIC CELL HYBRIDS
CHROMOSOME 10 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS CHROMOSOME 5 REGIONAL MAPPING PANEL SOMATIC CELL HYBRIDS
PRIMARY LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ALS PANEL; UPPER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL; LOWER-LIMB ONSET; DEFINITE AND PROBABLE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES RECQ PROTEIN-LIKE 2; RECQL2 NIA AGING CELL REPOSITORY DNA PANEL - CHARACTERIZED MUTATIONS WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED
WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED LAMIN A/C; LMNA NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
RECQ PROTEIN-LIKE 4; RECQL4 ROTHMUND-THOMSON SYNDROME; RTS NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS
AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; BULBAR ONSET; ALL DEFINITE ALS ALS PANEL CAUCASIAN FROM THE US
ROTHMUND-THOMSON SYNDROME; RTS NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
MRC-5 - NORMAL HUMAN FETAL LUNG FIBROBLAST
NIA AGING CELL REPOSITORY DNA PANEL - CHARACTERIZED MUTATIONS RECQ PROTEIN-LIKE 3; RECQL3 BLOOM SYNDROME; BLM
SAGUINUS NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: PHYLOGENETIC ORDER: PRIMATES
LAGOTHRIX ORDER: PRIMATES NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: PHYLOGENETIC
NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: YOUNG AND AGED FOR EACH SPECIES REPRESENTED ORDER: PRIMATES ERYTHROCEBUS
TIG-1 - NORMAL HUMAN FETAL LUNG FIBROBLAST
SV40 VIRUS-TRANSFORMED APPARENTLY HEALTHY: FETAL TISSUE
ORDER: PRIMATES NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: YOUNG AND AGED FOR EACH SPECIES REPRESENTED ERYTHROCEBUS
ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS ALS PANEL; UPPER-LIMB ONSET; DEFINITE AND PROBABLE ALS
ALZHEIMER DISEASE, FAMILIAL, TYPE 3 PRESENILIN 1; PSEN1
NIA AGING CELL REPOSITORY DNA PANEL - CHARACTERIZED MUTATIONS WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
WI-38 - NORMAL HUMAN FETAL LUNG FIBROBLAST
NIA AGING CELL REPOSITORY DNA PANEL - CHARACTERIZED MUTATIONS ALZHEIMER DISEASE, FAMILIAL, TYPE 3 PRESENILIN 1; PSEN1
WI-38 - SV40 VIRUS-TRANSFORMED FETAL LUNG FIBROBLAST
MACACA NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: YOUNG AND AGED FOR EACH SPECIES REPRESENTED ORDER: PRIMATES
NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: PHYLOGENETIC MACACA ORDER: PRIMATES
EXCISION-REPAIR CROSS-COMPLEMENTING, GROUP 8; ERCC8 NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES COCKAYNE SYNDROME, TYPE I; CKN1
LAMIN A/C; LMNA MANDIBULOACRAL DYSPLASIA WITH TYPE A LIPODYSTROPHY; MADA NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
PRIMATE PANEL LEMUR NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: YOUNG AND AGED FOR EACH SPECIES REPRESENTED NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: PHYLOGENETIC ORDER: PRIMATES
NIA AGING CELL REPOSITORY DNA PANEL - PRIMATE PANEL: YOUNG AND AGED FOR EACH SPECIES REPRESENTED LEMUR ORDER: PRIMATES
UNRELATED CONDITION UPON EXAM AMYOTROPHIC LATERAL SCLEROSIS
ALS PANEL; LOWER-LIMB ONSET; PROBABLE AND POSSIBLE ALS ALS PANEL CAUCASIAN FROM THE US AMYOTROPHIC LATERAL SCLEROSIS
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 13291
CEPH/UTAH PEDIGREE 1341 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
FRAGILE SITE MENTAL RETARDATION 1; FMR1 APPARENTLY HEALTHY NON-FETAL TISSUE
ADDITIONAL HUMAN/RAT SOMATIC CELL HYBRIDS
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1341 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 SNP500 PANEL CEPH/UTAH PEDIGREE 1331 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16
CEPH/UTAH PEDIGREE 1340 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
CEPH/UTAH PEDIGREE 1340 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
PRIMARY LATERAL SCLEROSIS ALS PANEL CAUCASIAN FROM THE US
FRAGILE SITE MENTAL RETARDATION 1; FMR1 CHROMOSOME DELETION
CEPH/UTAH PEDIGREE 1341 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
CEPH/UTAH PEDIGREE 13292 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE]
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1341 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
NIJMEGEN BREAKAGE SYNDROME GENE; NBS1 MARKER CHROMOSOME NIJMEGEN BREAKAGE SYNDROME
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1340
HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 8 INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1340 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 16 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 HUMAN VARIATION PANEL - EUROPEAN CAUCASIAN PANEL OF 24
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE II) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 13292
CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9 SNP500 PANEL CEPH/UTAH PEDIGREE 1333
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19 CEPH/UTAH PEDIGREE 1341
INTERNATIONAL HAPMAP PROJECT - CEPH (PLATE I) [UTAH RESIDENTS WITH ANCESTRY FROM NORTHERN AND WESTERN EUROPE] CEPH/UTAH PEDIGREE 1340 CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
HUTCHINSON-GILFORD PROGERIA SYNDROME; HGPS LAMIN A/C; LMNA
TRANSLOCATED CHROMOSOME TETRALOGY OF FALLOT
TRANSLOCATED CHROMOSOME FUMARATE HYDRATASE; FH
EHLERS-DANLOS SYNDROME, TYPE VII, AUTOSOMAL RECESSIVE
WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES RECQ PROTEIN-LIKE 2; RECQL2
A neoplastic (cancerous) leukocyte of the erythroid lineage characterized by immature red blood cell precursors (erythroblasts) that proliferate uncontrollably within the bone marrow and fail to differentiate into functional, oxygen-carrying erythrocytes.
Multipotent cell found within fat tissue.
A heterogeneous population of fetal cells found in the amniotic fluid.
obsolete Chorionic villus-derived cell line
NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES ROTHMUND-THOMSON SYNDROME; RTS
ACUTE MYELOGENOUS LEUKEMIA ATAXIA-TELANGIECTASIA; AT
IMR-90 - SV40 VIRUS-TRANSFORMED FETAL LUNG FIBROBLAST
NIA AGING CELL REPOSITORY DNA PANEL - CHARACTERIZED MUTATIONS RECQ PROTEIN-LIKE 2; RECQL2 WERNER SYNDROME; WRN REPLICATION FOCUS-FORMING ACTIVITY 1, INCLUDED; FFA1, INCLUDED NIA AGING CELL REPOSITORY DNA PANEL - AGING SYNDROMES
ATCC: COSMIC ID:910401; ATCC CRL-1923,CRL-1923
An immortal human B cell line cell originating from the ascitic fluid of humans with diffuse large B-cell lymphoma.
Stanford University-Diffuse Histiocytic Lymphoma-4
ATCC: HTB-93,COSMIC ID:909759; ATCC HTB-93
ATCC: CRL-7767,COSMIC ID:924248; ATCC CRL-7767
JCRB: COSMIC ID:907314; JCRB IFO50431,IFO50431
Derived from a subcutaneous nodule of a tumour from a 14-year-old male. Cells display remarkable blebbing.
DSMZ: ACC 193
ECACC: 93051123
HyperCLDB: cl852
HyperCLDB: cl853
HyperCLDB: cl854
ICLC: HTL97005
RIKEN: COSMIC ID:925339; Riken RCB1200,RCB1200
WEB: http://lincs.hms.harvard.edu/db/cells/50018/
WEB: https://www.ncbi.nlm.nih.gov/pubmed/22710073
WEB: https://www.ncbi.nlm.nih.gov/pubmed/9183638
ATCC: COSMIC ID:924247; ATCC HTB-117,HTB-117
ATCC: COSMIC ID:909758; ATCC HTB-118,HTB-118
MCF-12A cell
an immortal T cell line cell that is derived from mouse.
immortal mouse T cell line cell
An immortal human epithelial cell line cell that derives from human breast.
immortal human breast epithelial cell line cell
An immortal human epithelial cell line cell that derives from human colon.
immortal human colon epithelial cell line cell
An immortal human epithelial cell line cell that derives from human uterine cervix.
immortal human uterine cervix epithelial cell line cell
mouse C57BL/6 inbred strain
mouse C3H/An inbred strain
mouse DBA/2 inbred strain
An immortal mouse T cell line cell derived from a mouse lymphoma, specifically a Rauscher virus-induced tumor.This cell line is antigen processing-defective and expresses a very low level of MHC molecules on its surface.
WEB: http://web.expasy.org/cellosaurus/CVCL_J385
RMA cell
An immortal human B cell line cell originating from the blood of humans.
An immortal human B cell line cell originating from the blood of humans with multiple myeloma.
immortal chicken B cell line cell derives_from some B cell from the peritoneal sac of a chicken having leukosis
WEB: http://web.expasy.org/cellosaurus/CVCL_T444
LSCC-RP9 cell
UCI 107 cell is an immortal human epithelial cell line cell derives from some ovary epithelial cell from a patient having ovary serous adenocarcinoma.
WEB: http://web.expasy.org/cellosaurus/CVCL_5381
UCI 107 cell
UCI 101 cell is an immortal human epithelial cell line cell derives from some ovary epithelial cell from a patient having ovary serous adenocarcinoma.
WEB: http://web.expasy.org/cellosaurus/CVCL_5380
UCI 101 cell
an immortal human fibroblast cell line cell that is derived from BJ cell through a biological process such as cell transformation
BJ-derived cell line cell
BJeLR cell is BJ fibroblast cell line cell transformed with hTERT, genomic SV40 LT and ST oncoproteins, and oncogenic HRASV12.
PubChem probe report: http://www.ncbi.nlm.nih.gov/books/NBK98919/
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18355723
BJeLR cell
BJeH=BJ derivative transformed only with hTERT (BJ fibroblasts were derived from primary human cells by transformation with hTERT, genomic SV40 Large T (LT) and Ssmall T (ST))
BJeH cell
WEB: http://cellfinder.org/ontology?id=CELDA_00012667
RS-11846 cell
CHO-derived cell line cell
A derivative of the CHO cell line that is adapted to high-density, serum-free suspension culture
WEB: https://www.thermofisher.com/order/catalog/product/R80007
CHO-S cell
DRD=BJ fibroblasts expressing hTERT, SV40 small T oncoprotein, dominant negative p53, cyclin D1, a mutant form of CDK4, along with the oncogene HRASV12
WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683762/
DRD cell
HL2/3 is a derivative of HeLa cells and contains a stably integrated copies of the HIV-1 molecular clone HXB2/3gpt.
WEB: https://www.aidsreagent.org/reagentdetail.cfm?t=cell_lines&id=83
WEB: https://www.ncbi.nlm.nih.gov/pubmed/?term=2078409
HL2/3
HeLa-MAGI-CCR5 cells are derived from HeLa cells and express human CD4, CXCR4 and CCR5, and an integrated gene encoding the b-galactosidase gene expressed from the HIV long terminal repeat.
WEB: http://web.expasy.org/cellosaurus/CVCL_D260
MAGI-CCR5 cells; HeLa-R5-16, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL4 3
HeLa-MAGI-CCR5
HeLa-R5-16 (gift from Roche Palo Alto, LLC) is a derivative of HeLa cells, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL43
WEB: http://www.ncbi.nlm.nih.gov/pubmed/?term=16314403
HeLa-R5-16
RD-HGA16 is derivative of CHO cells stably transfected with the promiscuous G-protein Gα16 gene and hygromycin-resistant. RD-HGA16 is from FLIPR LiveWare Cells (Molecular Devices, Sunnyvale CA), a series of cells and expression vectors successfully used in drug discovery, based on G-protein chimeras developed by Bruce Conklin and colleagues at the Gladstone Institute, UCSF.
WEB: http://go.pardot.com/l/83942/2015-06-17/njr/83942/4464/Data_Sheet__FLIPR_LiveWare_G_protein_Cells_and_Plasmids.pdf
RD-HGA16
Sufu-KO-LIGHT cells were derived from Sufu knockout mouse embryonic fibroblasts according to the method of Chen et al. [Genes Dev. 2009;23(16): 1910-28.] The cells were co-transfected with the zeocin resistance vector (pVgRXR, Invitrogen) and a firefly luciferase reporter driven by eight Gli binding sites and a γ-crystallin basal promoter (8XGHBS-FL). Sufu-KO-LIGHT lacks Sufu and exhibits constitutive Hh target gene expression in response to endogenous Gli activators.
WEB: https://www.google.com/patents/WO2013192301A1?cl=en
Sufu-KO-LIGHT cell
A Hela-derived cell line cell that expresses ubiquitinated GFP (Green Fluroescent Protein)
Ub-G76V-GFP/HeLa
A cell line cell that is cultured in vitro and possesses two capabilities: (1) it can self-renew, which means that it can divide indefinitely while remaining in an undifferentiated state; and (2) it is pluripotent or multipotent, which means that it can differentiate to form a specialized cell type.
Yongqun He, Sirarat Sarntivijai, Alexander Diehl
WEB: https://en.wikipedia.org/wiki/Stem-cell_line
While stem cells hold great promise for biomedical research, the in vitro propagation and maintenance of these cells in an undifferentiated state is essential. Reference: https://www.atcc.org/~/media/7E031EF950594BC3B85A411AE1DC9684.ashx
stem cell line cell
MWCL.1 cell
The GripTite™ 293 MSR Cell Line is a genetically engineered Human Embryonic Kidney (HEK 293) cell line that expresses the human macrophage scavenger receptor and strongly adheres to standard tissue culture plates for dependable results.
GripTite 293 MSR cell
ECC-1 cell line cells have been found to be contaminated and shown to be a Ishikawa 3-H-12 cell line cell (PubMed=22710073).
Ishikawa 3-H-12 cell
WEB: http://genome.ucsc.edu/ENCODE/protocols/cell/human/ECC1_Myers_protocol.pdf
WEB: http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
ECC-1 cell
An immortal vasculature-derived cell line cell that derives from human endothelial cell.
immortal human vasculature-derived endothelial cell line cell
An immortal bone element-derived cell line cell that derives from human epithelial cell.
immortal human bone element-derived epithelial cell line cell
a SK-N-SH cell that is treated with retinoic acid to make the cell differentiated.
WEB: http://ucscbrowser.genap.ca/cgi-bin/hgEncodeVocab?ra=encode%2Fcv.ra&term=%22SK-N-SH_RA%22
WEB: https://www.ncbi.nlm.nih.gov/pubmed/26295826
WEB: https://www.ncbi.nlm.nih.gov/pubmed/?term=4748425
SK-N-SH-RA cell
An immortal pancreas-derived cell line cell that derives from human epithelial cell.
immortal human pancreas-derived epithelial cell line cell
An immortal kidney-derived cell line cell that derives from human epithelial cell.
immortal human kidney-derived epithelial cell line cell
293-derived cell
WEB: http://web.expasy.org/cellosaurus/CVCL_D585
WEB: http://www.thermofisher.com/order/catalog/product/R71007
HEK293-T-REx cell
MCF 10A-derived cell
The MCF10A-Er-Src cells are derived from the MCF-10A parental cells and contain ER-Src, a derivative of the Src kinase oncoprotein (v-Src) that is fused to the ligand-binding domain of the estrogen receptor (ER).
WEB: http://genome.ucsc.edu/ENCODE/protocols/cell/human/MCF-10A_Struhl_protocol.pdf
MCF10A-Er-Src cell
a hybridoma cell line cell that is obtained by fusing activated mouse T cells with tumor cells.
mouse T-cell hybridoma cell line cell
2B4 cell
A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein BCL-2.
2B4/BCL-2 cell
A stem cell line cell that is derived from mouse.
mouse stem cell line cell
A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein MCL-1.
2B4/MCL-1 cell
AVA5 cells are derived from the Huh-7 human hepatoma cell line, stably-expressing the HCV replicon (sub-genomic [CON1], genotype 1b); http://www.apath.com/index.html. See also PMID: 27013634, 1110665, 10390360
AVA5 cell
An immortal mouse cell line cell that is derived from leukemia cells.
mouse leukemia cell line cell
A murine leukemia cell line driven by the overexpression of Myc and BCL-2.
BCL-2 1863 cell
A mouse stem cell line cell that is derived from a mouse neural progenitor cell and capable of differentiation in vitro.
immortalized mouse neural progenitor cell
mouse neural progenitor cell line cell
An immortalised mouse neural progenitor cell line cell that is capable of differentiation in vitro and is established by retorviral-mediated transduction of the avian myc oncogene into mitotic progenitor cells of neonatal mouse cerrebellum. Mouse strain CD1 x C57BL/6.
C17.2 cell
CEM.NKR-CCR5 cell
CEM21 (aka CEM#21 or CEM-R5Luc1#21) is derived from CEM.NKR-CCR5 by stable transfecttion of a Tet-activator responsive Luciferase reporter
CEM21 cell
DPX2 (aka DPX-2) is a HepG2-derived cell line stably integrated with a PXR (pregnane X receptor) expression vector plus a luciferase reporter, used to detect PXR activation/ CYP3A induction
DPX2 cell
FA2N-4 is a human hepatocyte cell line. Reference: http://web.expasy.org/cellosaurus/CVCL_0267
FA2N-4 cell
An immortal human B cell line cell originating from the pleural effusion of a Japanese male with diffuse large B-cell lymphoma.
HMC-1-8 is a human breast cancer cell line
HMC-1-8 cell
HMLE_sh_ECAD is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down E-Cadherin (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT)
HMLE_sh_ECAD cell
HMLE_sh_eGFP is a human breast epithelial cell line containing shRNA to GFP (green fluorescent reporter); used as an isogenic control line for HMLE_sh_ECAD
HMLE_sh_eGFP cell
HMLE_sh_TWIST is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down TWIST (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT); isogenic with another CSC line, HMLE_sh_ECAD
HMLE_sh_TWIST cell
3T3-derived cell
An engineered 3T3 mouse fibroblast cell line, which expresses the firefly luciferase reporter gene under the control of Wnt-responsive promoters (TCF/LEF).
LEADING LIGHT Wnt Reporter cell line cell
MCL-1 1780 is a murine leukemia cell line driven by the overexpression of Myc and MCL-1.
MCL-1 1780 cell
MG213 is a subline of the BRG1/BRM-deficient cell line SW13 (http://purl.obolibrary.org/obo/CLO_0009185) that contains a stably integrated glucocorticoid-responsive MMTV-luciferase reporter.
MG213 cell
A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (DRD2L, long form of human DRD2) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD2L-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.
PathHunter CHO-K1 DRD2L Beta-Arrestin cell
A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (human DRD3) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD3-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.
PathHunter CHO-K1 DRD3 Beta-Arrestin cell
An immortal mouse moncyte cell line cell that is derived from RAW 264.7 cell line.
RAW 264.7-derived cell
RAW-Blue cells are derived from the murine RAW 264.7 macrophages with chromosomal integration of a secreted embryonic alkaline phosphatase (SEAP) reporter construct inducible by NF-κB and AP-1.
RAW-Blue cell
S16 cell
A mouse melanoma cell line (which harbors N-Ras mutation), isolated from a small amelanotic lung metastasis in a mouse with a s.c. K-1735 tumor.
SW1 cell
'Tango cell' refers to one of many stable cell lines, all based on the parental line HEK293T, designed to work in a 'Tango beta-arrestin' recruitiment assay to measure receptor activation for more than 300 GPCRs. See PMID25895059 and https://pdspdb.unc.edu/prestotango/
Tango cell
An immortal human B cell line cell originating from the bone marrow of humans with diffuse large B-cell lymphoma.
A primary culture cell that is derived from peripheral blood.
primary cultured peripheral blood cell
A primary cultured peripheral blood cell that has one round nucleus.
primary cultured peripheral blood mononuclear cell
U87-EGFRvIII (aka U87/vIII) is a stable cell line derived from U87MG (a human glioblastoma) to overexpress the most common mutation of epidermal growth factor receptor (EGFR) found in human glioblastomas--an in-frame deletion of an 801-bp sequence in the extracellular domain of EGFR termed EGFRvIII. (descr. in PMID 15548697).
U87-EGFRvIII cell
A primary cultured peripheral blood cell that derived erythroblast.
peripheral blood-derived erythroblast
A peripheral blood-derived erythroblast cell that is prepared from fetal liver
peripheral blood-derived erythroblast from fetal liver
A stem cell line cell that is dervied from an embryotic stem cell, a pluripotent stem cell derived from the inner cell mass of a blastocyst, an early-stage perimplantation embryo.
embryonic stem cell line cell
An embryonic stem cell line cell that is dervied from a cell in human embryo.
human embryonic stem cell line cell
A human ES cell line cell that expresses cell surface markers specific to undifferentiated nonhuman primate ES and human EC cells: : stage-specific embryonic antigen (SSEA)–3, SSEA-4, TRA-l-60, TRA-1- 81, and alkaline phosphatase. It has a normal 46, XY karyotype, O+ blood type. Teratomas are formed upon cell injection into SCID mice. These teratomas include cells from all three germ layers.
Line H1 cell
CL-34 cell
SNU-1040 cell
SNU-C4 cell
SNU-C5 cell
HEC-108 cell
COR123 cell
COV644 cell
SKM-1 cell
MDAMB231 cell
SKMEL1
The OV7 cell line was established from solid ovarian tumour tissue taken from a 78-year-old female patient. The tumour was characterised as stage III, mixed tumour type and poorly differentiated.
Immunocytochemical staining of the cells was reported to show strong staining for cytokeratin (CK), no staining for carcinoembryonic antigen (CEA) and strong staining for human milk fat globulin (HMFG-2). Detection of mRNA expression of vascular endothelial growth factor (VEGF) and its receptors flt and KDR has been reported. The patient had received treatment with chlorambucil. (Sigma-Aldrich catalog number 96020764)
OV7 cell
SKBR3 cell
human ovarian cancer cell line cell
This human ovarian adenocarcinoma cell line originated from a 62 year old Japanese female
RMUG-S cell
HEKTE cell
neuron cell derived from H1 embryonic stem cells
H1-neuron
LCL-1005
Ball-1
BALL-1 cell
CHEMBL: CHEMBL3308839
A primary cultured cell that is derived from fibroblast cell in vivo
Oliver He
primary cultured fibroblast cell
A primary cultured fibroblast cell that is from human
primary cultured human fibroblast cell
A stem cell line cell that is multipotent and is isolated and prepared from an juvenile or adult tissue.
adult stem cell line cell
An adult stem cell line cell that is isolated and prepared using bone marrow tissue and is able to generate all cells of the immune system and all blood cell types.
Of the types of adult stem cells have successfully been isolated and identified, only mesenchymal stem cells can successfully be grown in culture for long periods of time. Hematopoietic stem cells are difficult to grow and propagate in vitro.[4] Identifying methods for maintaining hematopoietic stem cells in vitro is an active area of research. Reference: https://en.wikipedia.org/wiki/Stem-cell_line
hematopoetic stem cell line cell
An adult stem cell line cell that is isolated and prepared using umbilical cord blood, amniotic fluid, and adipose tissue and can generate a number of cell types, including osteoblasts, chondrocytes, and adipocytes.
mesenchymal stem cell line cell
A mesenchymal stem cell line cell that is isolated and prepared using umbilical cord blood.
umbilical cord mesenchymal stem cell line cell
A stem cell line cell that is pluripotent and is generated from an adult somatic cell.
induced pluripotent stem cell line cell
An induced pluripotent stem cell line cell that is derived from a human cell.
human induced pluripotent stem cell line cell
non-tumorigenic
A cell growth process that is conducted in the three dimensional direction.
three dimensional cell growth
cell line cell transfection
This human ES cell line expresses cell surface markers specific to undifferentiated nonhuman primate ES and human EC cells: stage-specific embryonic antigen (SSEA)–3, SSEA-4, TRA-l-60, TRA-1- 81, and alkaline phosphatase. It has a normal 46, XX karyotype. Teratomas are formed upon cell injection into SCID mice. These teratomas include cells from all three germ layers.
H9 ES cell
HUES3 ES cell
A embryotic stem cell line cell that is dervied from a cell in mouse embryo.
mouse embryonic stem cell line cell
A stem cell line cell that is dervied from using the somatic cell nuclear transfer method.
somatic cell nuclear transfer-derived stem cell line cell
a human embryonic stem cell line cell that is derived by somatic cell nuclear transfer
human embryonic stem cell line cell derived by SCNT
human embryonic stem cell line cell derived by somatic cell nuclear transfer
human fibroblast-induced pluripotent stem cell line cell
A primary cultured cell that is derived from in vivo connective tissue cell
primary cultured connective tissue cell
A primary cultured cell that is derived from synovial cell in vivo
primary cultured synovial cell
A primary cultured cell that is derived from fat cell in vivo
primary cultured fat cell
A primary cultured cell that is derived from in vivo muscle cell.
primary cultured muscle cell
A primary cultured cell that is derived from in vivo cardiac muscle cell
primary cultured cardiac muscle cell
A primary cultured cell that is derived from in vivo bone marrow cell
primary cultured bone marrow cell
A primary cultured cell that is derived from in vivo muscle precursor cell
primary cultured muscle precursor cell
A primary cultured cell that is derived from myoblast cell.
primary cultured myoblast cell
A primary cultured cell that is derived from in vivo liver cell
primary cultured liver cell
A primary cultured cell that is derived from in vivo lymphocyte
primary cultured lymphocyte
A primary cultured cell that is derived from in vivo B cell
primary cultured B cell
A primary cultured cell that is derived from in vivo skeletal muscle cell.
primary cultured skeletal muscle cell
A stem cell line cell that is derived from human.
human stem cell line cell
human forskin fibroblast-induced pluripotent stem cell line cell
forskin fibroblast-derived hiPSC
BIHi001-A cell
immortal human lung-derived epithelial celll line cell
An organism that provides/donotes a tissue to be used for a biomedical study or a clinical application.
tissue donor
human tissue donor
EDi008-B
an organization that provides a place for registration and search of cell line information.
cell line registry
disease: ovarian carcinoma cancer cell line
Cellosaurus (https://web.expasy.org/cellosaurus/CVCL_6570)
HEK293 cells expressing E1A adenovirus gene, enabling viral promoter expression
ThermoFisher (https://www.thermofisher.com/order/catalog/product/11631017)
BG1 cells modified with a luciferase reporter at the human ESR1 alpha (estrogen receptor) gene and estrogen receptor response elements
Tox21 (https://tripod.nih.gov/tox/apps/assays/assays.jsp)
CHO cells modified with a luciferase reporter at a TET-on controlled Retinoid Orphan Receptor Gamma) transcription factor
GH3 cells modified to express luciferase-reporter tyroid receptor response elements
HCT 116 cells modified to express a beta-lactamase reporter under control of p53
HEK293 cells modified with a beta-lactamase reporter under control of an upstream activator sequence to respond to androgen receptor signalling
HEK293 cells modified with a beta-lactamase reporter under control of an upstream activator sequence to respond to estrogen receptor signalling
HEK293T cells modified with a beta-lactamase reporter under control of an upstream activator sequence to respond to farnesoid-X-receptor signalling
HEK293T cells modified with a beta-lactamase reporter under control of an upstream activator sequence to respond to retinoid-X-receptor signalling
HEK293T cells modified with a beta-lactamase reporter under control of an upstream activator sequence to respond to vitamin D receptor receptor signalling
HeLa cells modified with a beta-lactamase reporter under control of the ER stress response element
Cellosaurus (https://web.expasy.org/cellosaurus/CVCL_KS05)
HeLa cells modified with a beta-lactamase reporter under control of the glucocordicoid receptor
HeLa cells modified with a beta-lactamase reporter under control of the heat shock response elements
HepG2 cells modified with an aryl hydrocarbon receptor (AhR) luciferase reporter and 20 dioxin response elements
HepG2 cells modified with a beta-lactamase reporter under control of the antioxidant response element
HepG2 cells modified with a luciferase reporter responsive responsive to the activation of the contained constituitive androstane receptor and cytochrome 2B6
MCF-7 cells modified with a luciferase reporter and three repeats of the estrogen response element
MDA-kb2 cells modified with a luciferase reporter under control of the MMTV promotor and response elements for androgen receptor and glucocorticoid receptor
ME-180 cells modified with a beta lactamase reporter under control of the activator protein-1 response element
ME-180 cells modified with a beta lactamase reporter under control of thehypoxia response element
ME-180 cells modified with a beta lactamase reporter under control of an NF-kB response element
Cells modified with a reporter gene to respond to estrogen related receptor alpha activity
Cells modified with a reporter gene to respond to activity of the estrogen related receptor alpha and the PPARgamma coactivator
HEK293H cells modified with a beta lactamase reporter under control of an upstream activator sequence and peroxisome proliferator-activated receptor delta
HEK293H cells modified with a beta lactamase reporter under control of an upstream activator sequence and peroxisome proliferator-activated receptor gamma
C3H/10T1/2 clone 8 cells were modified with a luciferase reporter responding to activity of the retinoic acid signalling pathway
HEK293T cell
Human Embryonic Kidney 293T-derived cell
HEK293T-derived cell
HEK293H-derived cell
MEL cell line cell is an erythroid progenitor cell derived from the spleen of a susceptible mouse infected with the Friend virus complex 1. The virally transformed MEL cells are arrested at the proerythroblast stage of development and can be maintained in tissue culture indefinitely.
mouse erythroleukemia cell line cell
An immortal kidney podocyte-derived cell line cell
immortal podocyte cell line cell
An immortal podocyte cell line cell that derived from human.
immortal human podocyte cell line cell
An immortal podocyte cell line cell that derived from mouse.
immortal mouse podocyte cell line cell
An immortal podocyte cell line cell that derived from rat.
immortal rat podocyte cell line cell
E11 [mouse] cell
MPC-1 cell
MPC-5 cell
MPC-8 cell
SVI cell
2DNA1D7 cell
Conditionally Immortalized Human Podocytes-1
CIHP-1 cell
human Amniotic-fluid Kidney Progenitor Cells-Podocyte
hAKPC-P cell
Human Glomerular Visceral Epithelial Cells.SV40 transformed 1
HGVEC.SV1 cell
Human Glomerular Visceral Epithelial Cells.SV40 transformed 1 clone A4
HGVEC.SV1A4 cell
This cell was derived from an African American who had focal segmental glomerulosclerosis
HUPEC 001 G0/G0 cell
HUPEC 002 FSGS G0/G0 cell
HUPEC 003 FSGS G0/G0 cell
HUPEC 005 FSGS G1/G2 cell
This is an induced pluripotent stem cell
STBCi028-A cell
STBCi321-A cell
Cell provider: PromoCell; Cell provider catalog number: PromoCell
Cell provider: Cell Applications, Inc; Cell provider catalog number: Cell Applications, Inc
Cell provider: Wasington University; Cell provider catalog number: Wasington University
STBCi322-A cell
Cell provider: ISMMS; Cell provider catalog number: ISMMS
Cell provider: Lonza; Cell provider catalog number: Lonza
Cell provider: CellzDirect; Cell provider catalog number: CellzDirect
Cell provider: Sciencell; Cell provider catalog number: Sciencell
MDCK-II cell
Compared to the parent cell line, has a lower expression of endogenous ABCB1/MDR1.
MDCKII-LE cell
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS14iCTR-n6
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS83iCTR-33n1
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS25iCTR-18n2
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS28iALS-n2A
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS29iALS-n1N
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS30iALS-n1N
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS52iALS-n6A
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS32iSMA-n3
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS83iSMA-n5
Cell provider: Cedars-Sinai Stem Cell Core Laboratory; Cell provider catalog number: CS77iSMA-n5
human pluripotent stem cell medium, includign mTeSR
A T cell that has been engineered to express a Chimeric Antigen Receptor, which signals T cell to attack tumor cells.
Source for Synonyms: Zhang C, Durer S, Thandra KC, et al. Chimeric Antigen Receptor T-Cell Therapy. [Updated 2022 Oct 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537294/
CAR T-cell
RCB2320 cell is an immortal cell line cell that has the characteristics: Fibroblast-like cells derived from African Savannah Elephant. Primary cultured cells. Elephant cell lines require import and export permits according to the Convention on International Trade in Endangered Species (CITES).
Derived from tissue: ear in animal: African Savannah Elephant.
RCB0412 cell is an immortal cell line cell that has the characteristics: Pupal ovary hemocyte.
Derived from tissue: pupal ovary in animal: butterfly,swallow t..
RCB0556 cell is an immortal cell line cell that has the characteristics: Pupal ovary hemocyte.
A immortal cell line cell that has the characteristics: Eel hepatocyte. Cell growth is slow.
Derived from tissue: liver in animal: eel.
RCB0406 cell is an immortal cell line cell that has the characteristics: Pupal ovary hemocyte.
Derived from tissue: pupal ovary in animal: moth.
A immortal cell line cell that has the characteristics: Highly susceptible to nuclear polyhedrosis virus.
Derived from tissue: fat body, larval in animal: moth, mulberry tiger.
Originator: Mitsuhashi,Jun & Inoue, Hajime
A immortal cell line cell that has the characteristics: Cold water fish cell line. Cultured at 25 C. Relatively large chromosomes (Mode 23).
Derived from tissue: fin, caudal in animal: mudminnow, Central.
A immortal cell line cell that has the characteristics: Lung fibroblastic cell line derived from Tupaia belangeri. Tupaia cell lines require import and export permits according to the Convention on International Trade in Endangered Species (CITES).
Derived from tissue: lung in animal: tupaia.
Originator: Inui, Naomichi & Taketomi, Masako
A immortal human cell line cell that has the characteristics: Human cell line derived from primary effusion lymphoma (PEL).
Derived from tissue: ascites in animal: human.
A immortal human cell line cell that has the characteristics: Human bile duct carcinoma. This cell line produces carbohydrate antigen 19/9 in serum-free medium. TKG0389(Deposited from Tohoku Univ.).
Derived from tissue: bile duct, ascites meta in animal: human.
Originator: Miyagiwa, M. (Okayama Univ.)
A immortal human cell line cell that has the characteristics: Human cell line derived from extrahepatic bile duct carcinoma. TKG0367(Deposited from Tohoku Univ.).
Derived from tissue: common bile duct in animal: human.
A immortal human cell line cell that has the characteristics: High level of EGF receptor
Derived from tissue: epidermoid carcinoma in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derivd from epidermoid carcinoma. TKG0182 (Deposited from Tohoku Univ.).
RCB2348 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from osteosarcoma.
Derived from tissue: femur in animal: human.
A immortal human cell line cell that has the characteristics: It was initiated from a malignant gestational choriocarcinoma of the fetal placenta. Need to check response to hormones before use. Back up culture of ECA2687.
Derived from tissue: fetal placenta in animal: human.
A immortal human cell line cell that has the characteristics: Japanese gallbladder carcinoma from the same patient of TGBC1TKB.
Derived from tissue: gallbladder in animal: human.
Originator: Todoroki, T. & Ohno, T. & Kim, B.
A immortal human cell line cell that has the characteristics: Japanese gallbladder tumor passed through a nude mouse.
A immortal human cell line cell that has the characteristics: Human cell line derived from gallbladder carcinoma. TKG0642 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Japanese gallbladder carcinoma established from metastated ascite. Cell growth is slow.
Derived from tissue: gallbladder, ascites meta in animal: human.
A immortal human cell line cell that has the characteristics: Japanese gallbadder carcinoma metastated to lymph node from the same patient of TGBC2TKB. Cell growth is slow.
Derived from tissue: gallbladder, lymph node meta in animal: human.
A immortal human cell line cell that has the characteristics: Human lymphoid cell line derived from Burkitt's lymphoma. Tumorigenic in nude mouse.TKG0607 (Deposited from Tohoku Univ.).
Derived from tissue: ileocecal lymph node meta in animal: human.
Originator: Hayashi, Yutaka (Tohoku University)
A immortal human cell line cell that has the characteristics: Human rhabdomyosarcoma showing myogenic differentiation. TGFbeta inhibits it. Cell growth is slow.
Derived from tissue: left forearm in animal: human.
Originator: Ogose, Akira & Motoyama, Teiichi
RCB2229 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from osteosarcoma.
Derived from tissue: left humerus in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from myxofibrosarcoma.
Derived from tissue: left knee in animal: human.
A immortal human cell line cell that has the characteristics: Lung adenocarcinoma
Derived from tissue: lung in animal: human.
A immortal human cell line cell that has the characteristics: Lung carcinoma, refer to ATCC CCL185
A immortal human cell line cell that has the characteristics: Lung Cancer-1/squamous, floating variant, the same patient as RCB0455 LC-1/sq.
A immortal human cell line cell that has the characteristics: Japanese lung squamous carcinoma.
A immortal human cell line cell that has the characteristics: Small cell carcinoma, classic type. See Lu-134-B.
Originator: Terasaki, T. & Shimosato, Y.
A immortal human cell line cell that has the characteristics: Small cell carcinoma, classic type. See Lu-134-A.
A immortal human cell line cell that has the characteristics: Small cell carcinoma, variant type
A immortal human cell line cell that has the characteristics: Small cell carcinoma, classic type
Originator: Tsumuraya, M. & Nakajima, T.
A immortal human cell line cell that has the characteristics: Small cell carcimoma, classic type
A immortal human cell line cell that has the characteristics: SV40 transformed human lung fibroblast.
A immortal human cell line cell that has the characteristics: Human lung cancer derived cell.
A immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Oat cell type.
RCB1773 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Small cell carcinoma.
RCB1785 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Small cell carcinoma.
A immortal human cell line cell that has the characteristics: Lung giant cell carcinoma cell line derived from human. TKG0495 (Deposited from Tohoku Univ.).
Originator: Hirohashi, S. and Shimosatao, Y.
A immortal human cell line cell that has the characteristics: Human lung squamous cell carcinoma cell line. TKG0481(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Small cell carcinoma. TKG0503(Deposited from Tohoku Univ.)
A immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Small cell carcinoma. Mouse WA-mFib cells are the stromal cells for this cell line.
A immortal human cell line cell that has the characteristics: Human lung giant cell carcinoma cell line. TKG0496 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Transformed in vitro with carcinogen
Originator: Huh, Nam, Ho (Nanba, Masayoshi)
A immortal human cell line cell that has the characteristics: SV40-transformed WI-38.
A immortal human cell line cell that has the characteristics: Parent cell line of LC/sq-SFthe same patient as RCB0439 LC-F. Cell growth is slow.
A immortal human cell line cell that has the characteristics: Lung small cell carcinoma producing insulin-like growth factor II. Cell growth is slow.
A immortal human cell line cell that has the characteristics: Japanese lung adenocarcinoma, highly metastatic in SCID mice. Also refer to RCB0444 RCRF-LC-AI. Cell growth is slow.
A immortal human cell line cell that has the characteristics: Small lung carcinoma. PTHrP producing.
A immortal human cell line cell that has the characteristics: Human cell line derived from lung squamous cell carcinoma. Many granules are found in cytoplasma. HLA-A 11/24. TKG0301 (Deposited from Tohoku Univ.).
Originator: Kobayashi, SyunsukeS. (Tohoku Univ.)
A immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Small cell carcinoma. TKG0244(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Adenocarcinoma. TKG0177 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Small cell carcinoma. TKG0245(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Large cell carcinoma. TKG0181(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Normal human lung fibroblast.
A immortal human cell line cell that has the characteristics: Normal embryonic lung fibroblast.
A immortal human cell line cell that has the characteristics: Human cell line derived from lung adenosquamous cell carcinoma. HLA A2402/, B5201/, Cw01201/.
A immortal human cell line cell that has the characteristics: Human cell line derived from lung adenocarcinoma. HLA A2402/2402, B5201/5401, C0102/1202.
A immortal human cell line cell that has the characteristics: Human cell line derived from lung large cell carcinoma. HLA A0206/2601, B0702/3501, Cw0702/0801.
A immortal human cell line cell that has the characteristics: Human lung carcinoma cell line. TKG0442(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human lung small cell carcinoma cell line. ADH producing.
A immortal human cell line cell that has the characteristics: SV40-transformed, 6TG-resistant and HAT-sensitive.
RCB2834 cell is an immortal human cell line cell that has the characteristics: Human immortalized cell line derived from MRC5 cells.
RCB2833 cell is an immortal human cell line cell that has the characteristics: Human immortalized cell line derived from MRC5 cells.
A immortal human cell line cell that has the characteristics: Human lung squamous cell carcinoma cell line.TKG0494 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from lung adenocarcinoma cells.
A immortal human cell line cell that has the characteristics: Lung Cancer-1/squamous, serum-free cultured
A immortal human cell line cell that has the characteristics: Human cell line derived from lung adenocarcinoma cells. Differentiated type. Previous name:PC-14(RCB0446)
A immortal human cell line cell that has the characteristics: Human lung cancer cell line expressing capsid protein of human adenovirus.
A immortal human cell line cell that has the characteristics: Producing high level of anti-diuretic hormone.
Derived from tissue: lung, lymph node meta in animal: human.
RCB1772 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from lung cancer. Small cell carcinoma.
A immortal human cell line cell that has the characteristics: Lung large cell carcinoma producing CSF. Cell growth is slow.
A immortal human cell line cell that has the characteristics: Human cell line derived from synovial sarcoma.
Derived from tissue: lung, pleural effusion in animal: human.
A immortal human cell line cell that has the characteristics: Adenocarcinoma, moderately diffirentiated. Cell growth is slow.
Derived from tissue: lung, pleural fluid in animal: human.
A immortal human cell line cell that has the characteristics: Human large cell lung carcinoma. Taken from skin metastasis. In vivo-in vitro clonogenic assay.
Derived from tissue: lung, skin meta in animal: human.
Originator: Miyamoto, Tadaaki, Takiguchi, Yuichi
A immortal human cell line cell that has the characteristics: Japanese lung large cell carcinoma
Originator: Miyamoto, Tadaaki & Takiguchi,Yuichi
A immortal human cell line cell that has the characteristics: Malignant melanoma from lympho node.
Derived from tissue: lymph node in animal: human.
Originator: Ono, Isao & Isahiwata, Isamu &Isahikawa, Hiroshi
A immortal human cell line cell that has the characteristics: Fas-antigen expressing. Ligation with anti-Fas mAb does not induce apoptosis.
Derived from tissue: lymph node, B-lymphoma in animal: human.
Originator: Miyazawa, Keisuke & Uchida, Yoshiko
A immortal human cell line cell that has the characteristics: EB transformed B cell line
Derived from tissue: lymphoblast in animal: human.
A immortal human cell line cell that has the characteristics: Human B lymphoblastoid cell line (RCB2288 211-LCL) transformed with APR-MUC1 and PRC-MUC1 cDNAs. TKG0615(Deposited from Tohoku Univ.).
Derived from tissue: lymphoblastoid in animal: human.
A immortal human cell line cell that has the characteristics: Human derived T cell line. HTLV-1 pro-virus DNA(+). TKG0369 (Deposited from Tohoku Univ.).
Derived from tissue: lymphocytes (T cell ) in animal: human.
A immortal human cell line cell that has the characteristics: Human T cell line derived from acute T cell leukemia. TKG0377 (Deposited from Tohoku Univ.).
Derived from tissue: lymphoid,T-leukemia in animal: human.
RCB2292 cell is an immortal human cell line cell that has the characteristics: Human malignant pleural mesothelioma cell line.
Derived from tissue: malignant pleural mesothelioma, pleural fluid in animal: human.
RCB2293 cell is an immortal human cell line cell that has the characteristics: Human malignant pleural mesothelioma cell line.
A immortal human cell line cell that has the characteristics: Human fibrous histiocytoma. Showing fibroblastic- and histiocytic features.
Derived from tissue: maxilla in animal: human.
A immortal human cell line cell that has the characteristics: Japanese maxillary simus squamous carcinoma
Derived from tissue: maxillary sinus in animal: human.
Originator: Wakamatu, Yoshiko & Miyake, Masahiko
A immortal human cell line cell that has the characteristics: Melanin producing. Originated from the same site of HMV-I.
Derived from tissue: melanoma in animal: human.
A immortal human cell line cell that has the characteristics: Human melanoma, spindle-shaped. Said DOPA (+). Cell growth is slow.
Derived from tissue: melanoma, ascites meta in animal: human.
A immortal human cell line cell that has the characteristics: Serum-free medium-adapted MMAc cells. For SF culture, + insulin, hEGF, hydrocortisone, bovine pituit
A immortal human cell line cell that has the characteristics: Human cell line derived from neroblastoma of adrenal gland. TKG0468(Deposited from Tohoku Univ.).
Derived from tissue: neuroblastoma, adrenal gland in animal: human.
A immortal human cell line cell that has the characteristics: G-CSF and IL-1 producing oral squamous cell carcinoma, the same patient as T3M-1 Clone2 and CJM.
Derived from tissue: oral cavity in animal: human.
A immortal human cell line cell that has the characteristics: G-CSF producing oral squamous cell carcinoma, the same patient as T3M-1 Cl-10 and CJM. Cell growth is slow.
RCB1034 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as T3M-1 Clone2 and T3M-1 Cl-10.
Derived from tissue: oral, the thoracic cavity meta in animal: human.
RCB1035 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as T3M-1 Clone2 and T3M-1 Cl-10.
RCB1036 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as T3M-1 Clone2 and T3M-1 Cl-10.
RCB1037 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as T3M-1 Clone2 and T3M-1 Cl-10.
RCB1038 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as T3M-1 Clone2 and T3M-1 Cl-10.
RCB1039 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as T3M-1 Clone2 and T3M-1 Cl-10.
A immortal human cell line cell that has the characteristics: v-Ki-ras transformant TE85 cell line. HAT sensitive, neo resistant.
Derived from tissue: osteosarcoma in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from osteosarcoma. TKG0452(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. TKG0492 (Deposited from Tohoku Univ.).
Derived from tissue: pancreas in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. TKG0227(Deposited from Tohoku Univ.)
A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. Ductal origin. TKG0606(Deposited from Tohoku Univ.)
A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. TKG0630(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. RCB1972 is derived from the same patient. TKG0490 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human pancreatic carcinoma cell line. RCB2138 is derived from the same patient.TKG0239(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human pancreatic carcinoma cell line, the same patient as RCB2141. TKG0491(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic carcinoma. RCB1973 is derived from the same patient. TKG0493(Deposited from Tohoku Univ.).
RCB1008 cell is an immortal human cell line cell that has the characteristics: Pancreatic ductal cell carcinoma. PTHrP producing.
Derived from tissue: pancreas, ascites meta in animal: human.
A immortal human cell line cell that has the characteristics: Pancreatic ductal cell carcinoma. Mother cell line of KP4-1, -2, and -3.
RCB1006 cell is an immortal human cell line cell that has the characteristics: Pancreatic ductal cell carcinoma. PTHrP producing.
RCB1007 cell is an immortal human cell line cell that has the characteristics: Pancreatic ductal cell carcinoma. PTHrP producing.
A immortal human cell line cell that has the characteristics: Human cell line derived from liver metastasis of pancreas carcinoma. TKG0383 (Deposited from Tohoku Univ.).
Derived from tissue: pancreas, liver meta in animal: human.
A immortal human cell line cell that has the characteristics: Pancreatic adenocarcinoma producing CEA. K-ras activated. Cell growth is slow.
Derived from tissue: pancreas, lymph node meta in animal: human.
A immortal human cell line cell that has the characteristics: 3 cell lines from different metastases were established from the same patient. See TGBC51TKB. Cell growth is slow.
Derived from tissue: papilla vater, liver meta in animal: human.
A immortal human cell line cell that has the characteristics: 3 cell lines from different metastases were established from the same patient. See TGBC50TKB.
Derived from tissue: papilla vater, lymph node meta in animal: human.
A immortal human cell line cell that has the characteristics: 3 cell lines from different metastases were established from the same patient. See TGBC52TKB.
Derived from tissue: papilla vater, peritoneum meta in animal: human.
A immortal human cell line cell that has the characteristics: Isolated from a patient with hiper dopaminemia andnorepinephrinemia.
Derived from tissue: pelvic tumor in animal: human.
RIKEN: COSMIC ID:925342; Riken RCB0803,RCB0803
A immortal human cell line cell that has the characteristics: Benign mature tridermal teratoma.
Derived from tissue: peritoneum in animal: human.
Originator: Ishiwata, I. & Ono, I. & Ishikawa, H.
A immortal human cell line cell that has the characteristics: Methotrexate(MTX)-resistant K562 cell line
Derived from tissue: pleural effusion in animal: human.
A immortal human cell line cell that has the characteristics: Expressing P2U receptor acting in signal transduction pathway.
A immortal human cell line cell that has the characteristics: Subline of K562. Resistant to adriamycin. TKG0211 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Cloned U-937, differentiate with TNF
A immortal human cell line cell that has the characteristics: Human CML derived cell line. Deposited directly from the institution that has established this cell.
Originator: Lozzio, C.B. & Lozzio, B.B.
A immortal human cell line cell that has the characteristics: Human cell line derived from chronic myelogenous leukemia. Differentiate into mature erythrocytes. TKG0210 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Subline of K562 cell line. Resistant to vincristine. TKG0212 (Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Chronic myelogenous leukemia, sensitive to NK cell. Differentiate to erythroid cells .
RCB2214 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from retinoblastoma.
Derived from tissue: retinoblastoma in animal: human.
A immortal human cell line cell that has the characteristics: Human retinoblastoma cell line.
RCB2219 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from retinoblastoma.
RCB2208 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from retinoblastoma.
RCB2213 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from retinoblastoma.
RCB2217 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from retinoblastoma.
RCB2218 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from retinoblastoma.
A immortal human cell line cell that has the characteristics: Human cell line derived from retinoblastoma. Cell growth is slow.
A immortal human cell line cell that has the characteristics: Human retinoblastoma cell line derived from cervical lymph node metastasis.
Derived from tissue: retinoblastoma, cervical lymph node meta in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from schwannoma. TKG0454 (Deposited from Tohoku Univ.).
Derived from tissue: right arm in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from malignant melanoma. Cell growth is slow.
Derived from tissue: right heel in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from malignant peripheral nerve sheath tumor.
Derived from tissue: right thigh in animal: human.
A immortal human cell line cell that has the characteristics: Human sacrococcigeal teratoma.
Derived from tissue: sacrococcygeal in animal: human.
Originator: Ishiwata, I. & Ono, I. & Ishi kawa, H.
A immortal human cell line cell that has the characteristics: Osteogenic sarcoma
Derived from tissue: sarcoma in animal: human.
A immortal human cell line cell that has the characteristics: Rare peripheral neuroectodermal tumor cells. Use collagen-coated dish.
Derived from tissue: scapula, pleural fluid in animal: human.
A immortal human cell line cell that has the characteristics: Rheumatoid fibroblast-like synoviocyte transformed with SV40 T antigen. Respond to IL-1beta.
Derived from tissue: synovial in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from T cell leukemia. TKG0563(Deposited from Tohoku Univ.).
A immortal human cell line cell that has the characteristics: Human cell line derived from Hodgkin's lymphoma. TKG0198(Deposited from Tohoku Univ.).
Derived from tissue: T cell leukemia in animal: human.
A immortal human cell line cell that has the characteristics: Human neuroblastoma cell line. TKG0460(Deposited from Tohoku Univ.).
Derived from tissue: unknown in animal: human.
A immortal human cell line cell that has the characteristics: Human cell line derived from malignant peripheral nerve sheath tumor (MPNST).
RCB2361 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from epithelioid sarcoma. Derived from a different patient from the patient of HS-ES-1 cell line.
A immortal human cell line cell that has the characteristics: Human cell line derived from epithelioid sarcoma. Derived from a different patient from the patient of HS-ES-2M, 2R cell lines.
RCB2360 cell is an immortal human cell line cell that has the characteristics: Human cell line derived from epithelioid sarcoma. Derived from a different patient from the patient of HS-ES-1 cell line.
Derived from tissue: unknown, lung meta in animal: human.
A immortal human cell line cell that has the characteristics: Squamous carcinoma cells derived from human oral cancer.
Derived from tissue: upper gingiva in animal: human.
A immortal human cell line cell that has the characteristics: Embryonal rhabdomyosarcoma cell line derived from human. Transplantable in nude mouse.
Derived from tissue: urachus in animal: human.
A immortal human cell line cell that has the characteristics: Japanese choriocarcinoma cell line. Cell growth is slow.
Derived from tissue: uterine in animal: human.
A immortal cat cell line cell that has the characteristics: Cat cell line derived from lymphoma.
Derived from tissue: lymphoma in animal: cat.
A immortal frog cell line cell that has the characteristics: Frog (Xenopus laevis) cell line derived from liver.
Derived from tissue: liver in animal: frog.
A immortal frog cell line cell that has the characteristics: Melanophore derived cell line. Derived from Rana nigromaculata. Cell growth is slow.
Derived from tissue: skin in animal: frog.
RCB1734 cell is an immortal frog cell line cell that has the characteristics: Melanophore derived cell line. Derived from Rana porosa brevipoda (albino). Cell growth is slow.
A immortal frog cell line cell that has the characteristics: Frog (Xenopus laevis) cell line derived from subcutaneous tumor.
Derived from tissue: subcutaneous in animal: frog.
A immortal frog cell line cell that has the characteristics: Frog (Xenopus laevis) cell line derived from tadpole.
Derived from tissue: tadpole in animal: frog.
RCB1735 cell is an immortal frog cell line cell that has the characteristics: Melanophore derived cell line. Derived from Rana porosa brevipoda (albino). Cell growth is slow.
Derived from tissue: skin in animal: frog, albino.
A immortal hybrid cell line cell that has the characteristics: Human hybrid (T and B lymphoblast) cell line. Fusion cll line between 174 and CEM.T2. This hybrid cells do not express MHC class II. HLA-A2 positive.TKG 0599(Deposited from Tohoku Univ.).
Derived from tissue: hybrid cell in animal: human.
A immortal hybrid cell line cell that has the characteristics: Rat thymoma cell line fused to mouse cells during nude-mouse transplantation. Mouse chr. 5, 15, 17.
Derived from tissue: hybrid cell in animal: mouse x rat.
Originator: Lu, Jin & Matsuyama, Mutsushi
A immortal hybrid cell line cell that has the characteristics: Rat thymoma cell line fused to mouse cells during nude-mouse transplantation. Mouse chr. 5,7,15,17.
A immortal zebra fish cell line cell that has the characteristics: Zebrafish fin fibroblast. Cell growth is slow.
Derived from tissue: scale in animal: zebrafish.
A immortal mouse cell line cell that has the characteristics: Human myeloma. Lambda- chain producing.
Derived from tissue: myeloma, subcutaneous in animal: human.
A immortal mouse cell line cell that has the characteristics: Ehrlich's ascite tumor
Derived from tissue: ascites in animal: mouse.
A immortal mouse cell line cell that has the characteristics: 9,10-dimethyl-1,2benzanthracene induced lymphoma. Back up culture of ECA2504.
A immortal mouse cell line cell that has the characteristics: Highly metastatic and drug-resistant mouse tumor
Derived from tissue: lung in animal: mouse.
A immortal mouse cell line cell that has the characteristics: Rapidly growing lymphoma
Derived from tissue: lymph node in animal: mouse.
RCB0138 cell is an immortal mouse cell line cell that has the characteristics: Highly sensitive to X-ray irradiation.
A immortal mouse cell line cell that has the characteristics: Resistant to 6TG, isolated from M10
RCB0136 cell is an immortal mouse cell line cell that has the characteristics: Highly sensitive to X-ray irradiation.
A immortal mouse cell line cell that has the characteristics: Mouse lymphoid tumor, macrophage like. Buck-up culture of ECA85051501.
Derived from tissue: lymphoid tumor in animal: mouse.
A immortal mouse cell line cell that has the characteristics: Natural killer cell-sensitive mouse lymphoma.
Derived from tissue: lymphoma in animal: mouse.
RCB1144 cell is an immortal mouse cell line cell that has the characteristics: IL-3 dependent mouse myeloid cells. MoLV induced.
Derived from tissue: myeloid in animal: mouse.
A immortal mouse cell line cell that has the characteristics: Differentiate to macrophage and granulocyte
Derived from tissue: myeloid leukemia in animal: mouse.
RCB0095 cell is an immortal mouse cell line cell that has the characteristics: Myeloma.
Derived from tissue: myeloma in animal: mouse.
RCB0146 cell is an immortal mouse cell line cell that has the characteristics: Myeloma.
RCB0209 cell is an immortal mouse cell line cell that has the characteristics: Myeloma.
RCB0213 cell is an immortal mouse cell line cell that has the characteristics: Myeloma.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from neuroblastoma. TKG0509(Deposited from Tohoku Univ.).
Derived from tissue: neuroblastoma in animal: mouse.
A immortal mouse cell line cell that has the characteristics: Cytotoxic T-cell line. IL-2 dependent.
Derived from tissue: T cell in animal: mouse.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from fibrosarcoma. TNF resistant. BALB/c strain. TKG0281(Deposited from Tohoku Univ.).
Derived from tissue: fibrosarcoma in animal: mouse, BALB/c.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from fibrosarcoma. TNF sensitive. BALB/c strain. TKG0282(Deposited from Tohoku Univ.).
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from spontaneous malignant fibrous histiocytoma. A/J strain. TKG0497(Deposited from Tohoku Univ.).
Derived from tissue: left leg in animal: mouse, A/J.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from neuroblastoma. TKG0307 (Deposited from Tohoku Univ.).
Derived from tissue: neuroblastoma in animal: mouse, A/J.
A immortal mouse cell line cell that has the characteristics: Highly metastatic neuroblastoma
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from lymphoma. A/Sn strain. TKG0387 (Deposited from Tohoku Univ.).
Derived from tissue: lymphoma in animal: mouse, A/Sn.
A immortal mouse cell line cell that has the characteristics: Subline of OP9 cell line, expressing DLL1 and human NGF receptor. See RCB2120 TSt-4/N-DLL1.
Derived from tissue: newborn, calvaria in animal: mouse, B6C3Fe-a/a, op.
A immortal mouse cell line cell that has the characteristics: Subline of OP9 cell line, expressing human NGF receptor. Cell growth is slow. See RCB2119 TSt-4/N.
A immortal mouse cell line cell that has the characteristics: Subline of OP9 cell line, expressing EGFP. Cell growth is slow. See RCB2117 TSt-4/G.
A immortal mouse cell line cell that has the characteristics: Subline of OP9 cell line, expressing DLL1 and EGFP. Cell growth is slow. See RCB2118 TSt-4/G-DLL1.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from ascites. Macrophage-like cells. BALB/c strain. TKG0208(Deposited from Tohoku Univ.).
Derived from tissue: ascites in animal: mouse, BALB/c.
A immortal mouse cell line cell that has the characteristics: Macrophage-like cell
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from lymphoma. Balb/c strain. TKG0571 (Deposited from Tohoku Univ.).
Derived from tissue: lymphoma in animal: mouse, BALB/c.
RCB1143 cell is an immortal mouse cell line cell that has the characteristics: IL-3 dependent mouse myeloid cells. MoLV induced.
Derived from tissue: myeloid in animal: mouse, BALB/c.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from myelomonocytic leukemia cells. BALB/c strain. TKG0584(Deposited from Tohoku Univ.).
Derived from tissue: myelomonocyte in animal: mouse, BALB/c.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from bone marrow. Fibroblast-like. 6TG resistant. BALB/c strain. TKG0350(Deposited from Tohoku Univ.).
Derived from tissue: normal bone marrow, tibia, femur in animal: mouse, BALB/c.
A immortal mouse cell line cell that has the characteristics: Mouse osteosarcoma cell line. Transplantable to mouse and form bone tissue in mouse.
Derived from tissue: soft tissue tumor in animal: mouse, BALB/c.
A immortal mouse cell line cell that has the characteristics: A highly metastatic cell line derived from Dunn's osteosarcoma (C3H mouse origin).
Derived from tissue: bone in animal: mouse, C3H.
Originator: Aoki, Yasuaki & Ueda, Ueda, Takafumi
A immortal mouse cell line cell that has the characteristics: Mouse ES (RCB1778 H-1) cell derived cell, useful for study of hematopoiesis.
Derived from tissue: ES cell (H-1) in animal: mouse, C3H.
A immortal mouse cell line cell that has the characteristics: In vivo transplantable highly metastatic sarcoma
Derived from tissue: fibrosarcoma in animal: mouse, C3H.
A immortal mouse cell line cell that has the characteristics: Methylcholanthrene-induced fibrosarcoma. Metastatic to lung.
Derived from tissue: back in animal: mouse, C57BCF1.
RCB2695 cell is an immortal mouse cell line cell that has the characteristics: Mouse osteoblast-like cell line derived from Runx2 deficient mouse.
Derived from tissue: calvaria in animal: mouse, C57BL/6.
RCB2696 cell is an immortal mouse cell line cell that has the characteristics: Mouse osteoblast-like cell line derived from Runx2 deficient mouse.
A immortal mouse cell line cell that has the characteristics: Choroid plexus carcinoma cell line transfected with IgH enhancer-SV40 T fusion gene. Different shape
Derived from tissue: choroid in animal: mouse, C57BL/6.
A immortal mouse cell line cell that has the characteristics: Choroid plexus carcinoma cell line transfected with IgH enhancer-SV40 T fusion gene.
A immortal mouse cell line cell that has the characteristics: Mouse-derived gingival epithelial cell line. Derived from SV40-Large T antigen transgenic mouse.
Derived from tissue: gingival kerarinocyte in animal: mouse, C57BL/6.
A immortal mouse cell line cell that has the characteristics: Differentiate to osteoblasts. Collagen producing.
Derived from tissue: newborn, calvaria in animal: mouse, C57BL/6.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from Swiss Webster Sarcoma 180. CFW strain. TKG0637(Deposited from Tohoku Univ.).
Derived from tissue: sarcoma, ascitic tumor in animal: mouse, CFW.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from sarcoma cells in ascites. CFW strain. TKG0672(Deposited from Tohoku Univ.).
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from sarcoma cells in ascites. CFW strain. TKG0638(Deposited from Tohoku Univ.).
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from leukemia. Resistant to 6TG (10 microgram/ml). DBA/2 strain. TKG0478 (Deposited from Tohoku Univ.).
Derived from tissue: leukemia in animal: mouse, DBA/2.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from lung squamous cell carcinoma. TKG0473 (Deposited from Tohoku Univ.).
Derived from tissue: lung in animal: mouse, DBA/2.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from lung squamous cell carcinoma. TKG0214 (Deposited from Tohoku Univ.).
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from lymphoid tumor. DBA/2 strain. TKG0292 (Deposited from Tohoku Univ.).
Derived from tissue: lymphoid tumor in animal: mouse, DBA/2.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from lymphoid tumor. DBA/2 strain. TKG0326(Deposited from Tohoku Univ.).
A immortal mouse cell line cell that has the characteristics: Mouse mastocytoma. Used as a target cells for cytotoxic T cell assays.
Derived from tissue: mastocytoma in animal: mouse, DBA/2.
RCB1598 cell is an immortal mouse cell line cell that has the characteristics: Mouse T cell line transformed by Gross leukemia virus.
Derived from tissue: T cell in animal: mouse, H-2k.
RCB1597 cell is an immortal mouse cell line cell that has the characteristics: Mouse T cell line transformed by Gross leukemia virus.
RCB1600 cell is an immortal mouse cell line cell that has the characteristics: Mouse T cell line transformed by Gross leukemia virus.
RCB1601 cell is an immortal mouse cell line cell that has the characteristics: Mouse T cell line transformed by Gross leukemia virus.
A immortal mouse cell line cell that has the characteristics: Mouse cell line derived from meyloid leukemia. TKG0319 (Deposited from Tohoku Univ.).
Derived from tissue: myeloid leukemia in animal: mouse, SJ.
A immortal endothelial cell line cell that has the characteristics: Mouse vascular endothelial cell line. Transformed by ultraviolet.
Derived from tissue: vascular endothelial cell in animal: mouse,(BALB/c×C57BL/6)(CB6)F1.
RCB1855 cell is an immortal mononuclear phagocyte cell line cell that has the characteristics: T cell line derived from Chimpanzee (Pan troglodytes).
Derived from tissue: peripheral blood mononuclear cells in animal: chimpanzee.
RCB1854 cell is an immortal mononuclear phagocyte cell line cell that has the characteristics: T cell line derived from Chimpanzee (Pan troglodytes).
A immortal mononuclear phagocyte cell line cell that has the characteristics: Human B cell line transformed by Epstein-Barr Virus. HLA: A0206 and A2402. TKG0585 (Deposited from Tohoku Univ.).
Derived from tissue: peripheral blood mononuclear cells in animal: human.
Originator: Kudo, T. (IDAC Tohoku Univ.)
A immortal dendritic cell line cell that has the characteristics: Folicular dendritic cells derived from pituitary gland of temperature-sensitive T antigen transgenic mouse.
Derived from tissue: anterior pituitary gland in animal: mouse, C57BL.
A immortal blood cell line cell that has the characteristics: Susceptible to nuclear polyhedrosis virus
Derived from tissue: blood, larval in animal: armyworm, cabbage.
Originator: Mitsuhashi,Jun & Shozawa,Akiko
A immortal blood cell line cell that has the characteristics: larval hemocyte
Originator: Mitsuhashi, J. & Shozawa, A.
A immortal blood cell line cell that has the characteristics: Spont. transformant from choroid retina. Only slightly reactive to Factor VIII.
Derived from tissue: blood vessel endothelium in animal: monkey, rhesus.
A immortal connective tissue cell line cell that has the characteristics: Protein- & lipid-free medium growing
Derived from tissue: connective tissue in animal: mouse.
Originator: Katsuta,Hajim Takaoka,Toshiko
A immortal connective tissue cell line cell that has the characteristics: Thymidine kinase defective L cell
A immortal connective tissue cell line cell that has the characteristics: Sanford's original, brought by Katsuta at 7/5/1955. Insensitive to TNFalpha. Possible to culture in MEM medium.
A immortal connective tissue cell line cell that has the characteristics: Mouse fibroblast-like cell line. TKG0217 (Deposited from Tohoku Univ.).
A immortal connective tissue cell line cell that has the characteristics: TNFalpha-sensitive L929. Do not confuse with RCB0081 L929 that is insensitive to TNFalpha.
A immortal connective tissue cell line cell that has the characteristics: Mouse cell line derived from connective tissue. Fibroblast-like. C3H strain. TKG0218 (Deposited from Tohoku Univ.).
Derived from tissue: connective tissue in animal: mouse, C3H.
A immortal connective tissue cell line cell that has the characteristics: A subline of LAG (RCB2758) expressing MUC1. 8-Ag resistant. TKG0466(Deposited from Tohoku Univ.).
A immortal connective tissue cell line cell that has the characteristics: Rat fibroblast-like cell line that can be transformed by oncogenes.
Derived from tissue: connective tissue in animal: rat.
A hybridoma cell line cell that has the characteristics: Mouse T cell hybridoma expressing double HA-tag alone.
Derived from tissue: T cell hybridoma in animal: mouse.
A hybridoma cell line cell that has the characteristics: Mouse T cell hybridoma (DO-11.10) expressing double HA-tagged HS1BP3 (HS1 SH3 domain binding protein)-C2.
A hybridoma cell line cell that has the characteristics: Mouse T cell hybridoma (DO-11.10) expressing double Myc-tagged HS1BP3 (HS1 SH3 domain binding protein)-C2 .
RCB1608 cell is a hybridoma cell line cell that has the characteristics: Mouse T cell hybridoma (DO-11.10) expressing double HA-tagged HS1BP3 (HS1 SH3 domain binding protein).
A hybridoma cell line cell that has the characteristics: Mouse T cell hybridoma ((DO-11.10)expressing double HA-tagged HS1BP3 (HS1 SH3 domain binding protein)-C2.
RCB1607 cell is a hybridoma cell line cell that has the characteristics: Mouse T cell hybridoma (DO-11.10) expressing double HA-tagged HS1BP3 (HS1 SH3 domain binding protein).
A hybridoma cell line cell that has the characteristics: IL-5 producing T-cell hybridoma. Culture sup is useful for T88-M cell culture.
A immortal spleen-derived cell line cell that has the characteristics: T cell line derived from Cynomolgus Monkey (Macaca fascicularis)
Derived from tissue: spleen in animal: monkey, cynomolgus.
A immortal kidney-derived cell line cell that has the characteristics: Frog (Xenopus laevis) cell line derived from kidney.
Derived from tissue: kidney in animal: frog.
A immortal kidney-derived cell line cell that has the characteristics: Susceptible to rubella virus, equiv. to ATCC CCL37
Derived from tissue: kidney in animal: rabbit.
A immortal kidney-derived cell line cell that has the characteristics: Rabbit kidney cell line transformed by SV40 large T antigen. Derived from renal proximal tubules.
A immortal kidney-derived cell line cell that has the characteristics: Rabbit kidney cell line transformed by SV40 large T antigen. Derived from renal distal tubules.
A immortal kidney-derived cell line cell that has the characteristics: Rabbit kidney cell line transformed by SV40 large T antigen. Derived from renal cortical collecting tubules.
A immortal embryo-derived cell line cell that has the characteristics: Highly metastatic sarcoma, synthesize hematoside
Derived from tissue: embryo in animal: hamster.
RCB0244 cell is an immortal embryo-derived cell line cell that has the characteristics: Highly metastatic sarcoma.
RCB0243 cell is an immortal embryo-derived cell line cell that has the characteristics: Highly metastatic sarcoma.
A immortal embryo-derived cell line cell that has the characteristics: Initially insulin and glucagon producing, but not now. See RCB0795,0796,0797.
Derived from tissue: embryo, pancreas in animal: human.
A immortal embryo-derived cell line cell that has the characteristics: Human embryonic pancreas-derived cell line. See RCB0794,0795,0796.
A immortal embryo-derived cell line cell that has the characteristics: Human embryonic pancreas-derived cell line. See RCB0794,0796,0797.
A immortal embryo-derived cell line cell that has the characteristics: Human embryonic pancreas-derived cell line. See RCB0794,0795,0797.
A immortal embryo-derived cell line cell that has the characteristics: Primary culture of suncus whole embryo
Derived from tissue: embryo in animal: suncus.
RCB0477 cell is an immortal somatic nervous system-derived cell line cell that has the characteristics: N-myc gene amplification.
Derived from tissue: nervous system in animal: human.
RCB0484 cell is an immortal somatic nervous system-derived cell line cell that has the characteristics: N-myc gene amplification.
A immortal somatic nervous system-derived cell line cell that has the characteristics: N-myc gene unamplified tumor. Cell growth is slow.
RCB0485 cell is an immortal somatic nervous system-derived cell line cell that has the characteristics: N-myc gene amplification.
Derived from tissue: neuroblastoma in animal: human.
RCB0481 cell is an immortal somatic nervous system-derived cell line cell that has the characteristics: N-myc gene amplification.
A immortal somatic nervous system-derived cell line cell that has the characteristics: N-myc gene amplification. Cell growth is slow.
A immortal somatic nervous system-derived cell line cell that has the characteristics: Human cell line derived from neuroblastoma. TKG0448(Deposited from Tohoku Univ.).
A immortal somatic nervous system-derived cell line cell that has the characteristics: Neuroblastoma, a target in CTL assay
A immortal somatic nervous system-derived cell line cell that has the characteristics: Subline of GOTO. Protein-free medium adapted. Cell growth is slow.
A immortal liver-derived cell line cell that has the characteristics: Hepatocyte from the fish, Tilapia (Oreocheomis niloticus). Cell growth is slow.
Derived from tissue: liver in animal: tilapia.
A immortal pituitary gland-derived cell line cell that has the characteristics: Pituitary folliculo-stellate-like cells. GFAP positive and S-100 positive.
Derived from tissue: pituitary in animal: mouse.
A immortal pituitary gland-derived cell line cell that has the characteristics: Macrophage-like tumor dependent on L929 conditioned medium.
RCB1530 cell is an immortal bone marrow-derived cell line cell that has the characteristics: Bone marrow stroma cell line, depositing calcified matrix on the culture surface. TRAP-positive.
Derived from tissue: bone marrow in animal: hamster, Syrian.
RCB1528 cell is an immortal bone marrow-derived cell line cell that has the characteristics: Bone marrow stroma cell line, depositing calcified matrix on the culture surface. TRAP-positive.
RCB1531 cell is an immortal bone marrow-derived cell line cell that has the characteristics: Bone marrow stroma cell line, depositing calcified matrix on the culture surface. TRAP-positive.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-human lung carcinoma mAb (IgM). Possible to culture in serum-free medium.
Derived from tissue: hybridoma in animal: human x human.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing anti-E antigen of the human Rh blood group system
Derived from tissue: hybridoma in animal: human x mouse.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against MuSc.
Derived from tissue: hybridoma in animal: mouse x hamster.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against mouse apolipoprotein E.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybrid cell line of C3H mouse mammary tumor cell, FM3A#2, and 8-Ag resistant L cell. TKG0381(Deposited from Tohoku Univ.).
Derived from tissue: hybrid cell , FM3A#2 x L cell (8-Ag resistant) in animal: mouse x mouse.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma that produce anti-human G1MF (allotype of IgG1) antibody.
Derived from tissue: hybridoma in animal: mouse x mouse.
RCB0195 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-SV40 large T antigen mAb (IgG).
RCB1142 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti poly(ADP-ribose) IgG3 kappa producing.
A mouse x mouse hybridoma cell line cell that has the characteristics: MoAb IgM to sea urchin sperm dynein IC2.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-rabbit muscle lactate dehydrogenase (LDH) mAb (IgG2b). Possible to culture in serum-free medium
RCB0026 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-SV40 large T antigen mAb (IgG).
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-rabbit muscle glyceraldehyde-3-phosphate dehydrogenase mAb (IgG). Serum-free culturable.
A mouse x mouse hybridoma cell line cell that has the characteristics: Producing anti-human CD36 MoAb.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-chicken IgM antibody secreting. Able to stimulate DT40 cell surface antigen.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-recA protein mAb (IgG1)
A mouse x mouse hybridoma cell line cell that has the characteristics: MoAb IgG1 to sea urchin sperm dynein IC2.
A mouse x mouse hybridoma cell line cell that has the characteristics: MoAb IgM to sea urchin sperm dynein alpha-heavy chain.
RCB0646 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb IgM to sea urchin sperm dynein beta-heavy chain.
RCB0648 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb IgM to sea urchin sperm dynein beta-heavy chain.
A mouse x mouse hybridoma cell line cell that has the characteristics: MoAb IgG1 to sea urchin sperm dynein IC3.
A mouse x mouse hybridoma cell line cell that has the characteristics: Producing IgG MoAb against human 29 kDa lectin detectable in many human tumors. Also see HH17-4.
A mouse x mouse hybridoma cell line cell that has the characteristics: Producing IgG MoAb against human 29 kDa lectin detectable in many human tumors. Also see HH13-1.
RCB0705 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti poly(ADP-ribose) IgG3 kappa producing.
RCB0673 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma against differentiated PC-12 cell surface.
RCB0678 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma against differentiated PC-12 cell surface.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-ribonuclease A antibody producing.
Originator: Suga, Ken-ichi & Omasa, Takeshi
RCB0669 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma against differentiated PC-12 cell surface.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-rabbit muscle lactate dehydrogenase (LDH) mAb (IgG1). Possible to culture in serum-free medium.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-chick αB-crystallin MoAb producing. Bacteria(+), therefore, must add penicillin+streptomycin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-chick β5-crystallin MoAb producing. Bacteria(+), therefore, must add penicillin+streptomycin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-chick β6-crystallin MoAb producing. Bacteria(+), therefore, must add penicillin+streptomycin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-newt γ1-crystallin MoAb producing. Bacteria(+), therefore, must add penicillin+streptomycin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-2,3 MoAb (IgG1) producing.
RCB1220 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-2 MoAb (IgG1) producing.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-3 MoAb (IgG1) producing.
RCB1229 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-4 MoAb (IgG1) producing.
RCB1240 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb to Clostridium perfringens alpha-toxin (phospholipase C).
RCB1247 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb to Clostridium perfringens alpha-toxin (phospholipase C).
A mouse x mouse hybridoma cell line cell that has the characteristics: MoAb to Clostridium perfringens theta-toxin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-chick αA-crystallin MoAb producing. Bacteria(+), therefore, must add penicillin+streptomycin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-lactotetraosylceramide antibody producing. Discriminates metastatic cells from mesothelial cell
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-recA protein mAb (IgG2b)
RCB1837 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Medaka Vitellogenin.
RCB1838 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Medaka Vitellogenin.
RCB1840 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Medaka Vitellogenin.
RCB1841 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Medaka Vitellogenin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-chick δ-crystallin MoAb producing. Bacteria(+), therefore, must add penicillin+streptomycin.
A mouse x mouse hybridoma cell line cell that has the characteristics: MoAb IgM to sea urchin sperm dynein IC1.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against tetrodotoxin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against domoic acid.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against gonyautoxin.
RCB1914 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Broad bean wilt virus 2 22-kDa coat protein.
RCB1916 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Broad bean wilt virus 2 22-kDa coat protein.
RCB1915 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Broad bean wilt virus 2 22-kDa coat protein.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against N-linked neutral oligosaccharides of glycoproteins.
Register: Kawashima, Ikuo (Tai, Tadashi)
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against F1-linked neutral oligosaccharides of glycoproteins.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against M1-linked neutral oligosaccharides of glycoproteins.
RCB1839 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Medaka Vitellogenin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against ganglioside lactones.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against N-glycolylneuraminic acid-containing gangliosides (GD3 gangliosides).
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against GD2 gangliosides (b-pathway gangliosides).
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against GQ1ba gangliosides.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against 2-3NeuAca-nLc4Cer gangliosides.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against nLc4Cer.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against SGPG.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against GalCer.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Sulfatide.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against Globoside.
RCB1246 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb to Clostridium perfringens alpha-toxin (phospholipase C).
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-1 MoAb (IgG2a) producing.
RCB1243 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb to Clostridium perfringens alpha-toxin (phospholipase C).
RCB1244 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb to Clostridium perfringens alpha-toxin (phospholipase C).
RCB1248 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: MoAb to Clostridium perfringens alpha-toxin (phospholipase C).
RCB1922 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing antibody against the purified basal apparatus of sperm of the an-1 strain of fern Lygodium.
RCB1923 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing antibody against the purified basal apparatus of sperm of the an-1 strain of fern Lygodium.
RCB1924 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing antibody against the purified basal apparatus of sperm of the an-1 strain of fern Lygodium.
RCB1918 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against mouse JDP2.
RCB0674 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against differentiated PC-12 cell surface molecules.
RCB0676 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against differentiated PC-12 cell surface molecules.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against GD1c gangliosides.
RCB2203 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against a surface antigen of small cell carcinoma of lung.
RCB2204 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against a surface antigen of small cell carcinoma of lung.
RCB1208 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-1 MoAb (IgG1) producing.
RCB1209 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-1 MoAb (IgG1) producing.
RCB0867 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-human-myeloperoxidase MoAb producing.
RCB0868 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-human-myeloperoxidase MoAb producing.
RCB0869 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-human-myeloperoxidase MoAb producing.
RCB0870 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-human-myeloperoxidase MoAb producing.
RCB2382 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on pharynx.
RCB2367 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on P-granule.
RCB2368 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on P-granule.
RCB2369 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on P-granule and body wall muscle.
RCB2372 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on P-granule and body wall muscle.
RCB2375 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on body wall muscle.
RCB2376 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on body wall muscle.
RCB2377 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on body wall muscle.
RCB2378 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on body wall muscle.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that seam cell.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on pharynx basement membrane.
RCB2381 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on pharynx.
RCB2383 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on pharynx.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on centrosome.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on hypodermis.
RCB2392 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on egg shell.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against WASP (Wiscott-Aldolich syndrome protein). TKG0631 (Deposited from Tohoku Univ.).
RCB2393 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on egg shell.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on P-granule and pharynx.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on centrosome and P-granule.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against GD1b gangliosides.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti human c-myc p62 mAb (IgG1.kappa)
A mouse x mouse hybridoma cell line cell that has the characteristics: Responding to IL-6 in the bioassay.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against N-glycolylneuraminic acid-containing gangliosides (GM3 gangliosides).
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against latexin.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against C-terminal peptide of rat GSK3-beta.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on intestine.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against oxitocin receptor.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against a peptide, GYPGQV.
RCB1238 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis filamentous hemagglutinin (FHA) MoAb producing.
RCB1239 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis filamentous hemagglutinin (FHA) MoAb producing.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against mouse JDP2. The antibody recognizes a truncated from of JDP2.
RCB1920 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against mouse JDP2.
A mouse x mouse hybridoma cell line cell that has the characteristics: Anti-thymine dimer antibody producing. Serum-free cultured hybridoma.
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against an antigen of C. elegans embryo. Antigen is not determined but that on nuclear membrane.
RCB1214 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-1 MoAb (IgG1) producing.
RCB1233 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-4 MoAb (IgG1) producing.
RCB1222 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-2 MoAb (IgG1) producing.
RCB1212 cell is a mouse x mouse hybridoma cell line cell that has the characteristics: Anti-pertussis toxin subunit S-1 MoAb (IgG1) producing.
A mouse x mouse hybridoma cell line cell that has the characteristics: S. cerevisiae Endo.Sce I large subunit mAb (IgG2b)
A mouse x mouse hybridoma cell line cell that has the characteristics: Hybridoma. Anti-Rat Carboxypeptidase M MoAb producing.
A immortal cornea-derived cell line cell that has the characteristics: SV40-Adeno vector transformed cornea cells. 64kD keratin producing. Choleratoxin-free medium.
Derived from tissue: cornea in animal: human.
A immortal cornea-derived cell line cell that has the characteristics: This cell line is provided only in Japan.
A immortal cornea-derived cell line cell that has the characteristics: Fibroblast-like cell line derived from rabbit.
Derived from tissue: cornea in animal: rabbit.
A immortal cornea-derived cell line cell that has the characteristics: Normal rabbit cornea cells. Usually transform spontaneously during serial culture.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: A subline of CHO cells. Require proline. TKG0328(Deposited from Tohoku Univ.).
Derived from tissue: ovary in animal: chinese hamster.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: SPB-1 derivative complemented the Serine-palmitoyl transferase deficiency.
Derived from tissue: ovary in animal: hamster, Chinese.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: LY-B derivative complemented the Serine-palmitoyl transferase (LCB1 subunit) deficiency.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Subline of CHO-K1 that expresses human leukotriene B4 receptor (BLT1).
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Subline of CHO-K1 that expresses human leukotriene B4 receptor (BLT2).
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Serine-palmitoyl transferase deficient (temperature-sensitive) cells derived from CHO-K1 cell line.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Serine-palmitoyl transferase (LCB1 subunit) deficient cells derived from CHO-K1 cell line.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Nalidixic acid sensitive mutant. Also sensitive toVP-16 and VM-26 Topo II inhibitors.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Subline of CHO-K1 cell line in which trafficking of ceramide is deficient
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Subline of LY-A in which human CERT cDNA are expressed and trafficking of ceramide is recovered
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: A subline of the CHO-K1 cell line. Widely used for the isolation of repair-deficient mutants. Useful for gene mutation assays at the APRT and HPRT loci.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Chinese hamster ovary cell line. Widely used for the isolation of mutants by mutagenesis.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Subline of CHO cells. Derived from CHO-K1 cell line. Serum-free medium adapted.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: CHO-K1 maintained in suspension culture.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Widely used cell line, especially for biotechnol
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: A subline of the CHO-K1 cell line. X-ray-sensitive mutant derived from CHO-AA8 cell line. XRCC1 gene deficient.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: A subline of the CHO-K1 cell line. X-ray-sensitive mutant derived from CHO-AA8 cell line. XRCC3 gene deficient.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: A subline of the CHO-K1 cell line. X-ray-sensitive mutant. XRCC4 gene deficient.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: Subline of CHO-K1 that expresses human platelet activating factor receptor.
A immortal Chinese hamster animal ovary-derived fibroblast cell line cell that has the characteristics: A subline of the CHO-K1 cell line. X-ray-sensitive mutant derived from CHO-AA8 cell line. XRCC7(DNA-PK) gene deficient.
A immortal human umbilical cord-derived fibroblast cell line cell that has the characteristics: Normal umbilical card fibroblast, female
Derived from tissue: umbilical cord in animal: human.
A immortal human umbilical cord-derived fibroblast cell line cell that has the characteristics: Normal umbilical cord fibroblast, female
RCB0197 cell is an immortal human umbilical cord-derived fibroblast cell line cell that has the characteristics: Normal umbilical cord fibroblast, male.
RCB0437 cell is an immortal human umbilical cord-derived fibroblast cell line cell that has the characteristics: Normal umbilical cord fibroblast, male.
A immortal human umbilical cord-derived fibroblast cell line cell that has the characteristics: Human mesenchymal cell line derived from umbilical cord blood. Immortalized by hTERT.
Derived from tissue: umbilical cord blood in animal: human.
A immortal human umbilical cord-derived fibroblast cell line cell that has the characteristics: Human mesenchymal cell line derived from umbilical cord blood. Immortalized by HPV E6, E7, and hTERT.
RCB2233 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
Derived from tissue: embryo in animal: human.
RCB2234 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2237 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2238 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2239 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2240 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2241 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2244 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2245 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2246 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2247 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2248 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2249 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2250 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2251 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2254 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2256 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2257 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2258 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2259 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2262 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2260 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2261 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2263 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2264 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2265 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2267 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2268 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2269 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2271 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2273 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2266 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
RCB2270 cell is an immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human fibroblast-like cells derived from embryo. Not immortalized.
A immortal human embryo-derived fibroblast cell line cell that has the characteristics: Human cell line derived from embryonic fibroblasts. Characteristics Embryonal fibroblast immortalized by 60-Co irradiation (400 Rad x 1 time and 200 rad x 12 times). Non-tumorigenic. TKG0482 (Deposited from Tohoku Univ.).
Derived from tissue: embryonal fibroblast in animal: human.
A immortal cattle cell line cell that has the characteristics: Bovine leukemia virus producing. Surface Ig (+).
Derived from tissue: blood in animal: bovine.
A immortal cattle cell line cell that has the characteristics: Bovine B cell leukemia without virus production
A immortal cattle cell line cell that has the characteristics: Bovine granulosa cell line.
Derived from tissue: granulosa cell in animal: bovine.
A immortal cattle cell line cell that has the characteristics: Useful for bovine virus testing
Derived from tissue: lymph node in animal: bovine.
A immortal cattle cell line cell that has the characteristics: Bovine pulmonary artery endothelial cells producing angiotensin-converting enzyme. Bovine Viral Diarrhea Virus (BVDV) positive. Backup of ECA86111401.
Derived from tissue: pulmonary artery endothelium in animal: bovine.
A immortal human lymphocyte cell line cell that has the characteristics: Human cell line derived from B cells in umbilical cord blood. Transformed by EB virus. TKG0305(Deposited from Tohoku Univ.).
Derived from tissue: cord blood lymphocytes in animal: human.
A immortal human lymphocyte cell line cell that has the characteristics: Human cell line derived from p180-BCR-ABL dependent leukemia.
Derived from tissue: peripheral blood lymphocytes in animal: human.
A immortal human lymphocyte cell line cell that has the characteristics: Lymphoblastoid cell line established by EBV infection from XP patient, variant type. TKG0309 (Deposited from Tohoku Univ.).
Originator: Tohda, H. (IDAC Tohoku Univ.)
A immortal human lymphocyte cell line cell that has the characteristics: Human B cells derived from a patient of xeroderma pigmentosum. Transformed by Epstein-Barr virus. TKG0313(Deposited from Tohoku Univ.).
A immortal human lymphocyte cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome (questionable) patient's skin. The same patient as GMC0025.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus. The same patient as GMC0002.
GMC0003 cell is an immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus. The same patient as GMC0012.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome (questionable) patient and transformed by Epstein-Barr Virus. The same patient as GMC0014.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus.The same patient as GMC0022.
GMC0019 cell is an immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome (questionable) patient and transformed by Epstein-Barr Virus.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome (questionable) patient and transformed by Epstein-Barr Virus. The same patient as GMC0024.
GMC0023 cell is an immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome (questionable) patient and transformed by Epstein-Barr Virus. The same patient as GMC0027.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus. he same patient as GMC0028.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus. The same patient as GMC0031.
GMC0032 cell is an immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome (questionable) patient and transformed by Epstein-Barr Virus.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus. The same patient as GMC0036.
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line transformed by Epstein-Barr Virus. TKG0614(Deposited from Tohoku Univ.).
A immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from xeroderma pigmentosum (XP) patient and transformed by Epstein-Barr Virus. TKG0312(Deposited from Tohoku Univ.).
GMC0016 cell is an immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus.
GMC0013 cell is an immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus.
GMC0026 cell is an immortal human lymphocyte cell line cell that has the characteristics: Human B cell line derived from Werner syndrome patient and transformed by Epstein-Barr Virus.
A immortal cabbage moth larva-derived cell line cell that has the characteristics: Cabbage armyworm cell line applicable to large scaale production of insect virus.
Derived from tissue: fat body, larval in animal: armyworm, cabbage.
Originator: Inoue, Hajime & Mitsuhashi,Jun
A immortal cabbage moth larva-derived cell line cell that has the characteristics: Larval fat body hemocyte.
Originator: Inoue,Hajime & Mitsuhashi, Jun
A immortal cabbage moth larva-derived cell line cell that has the characteristics: Cabbage armyworm cell line applicable to large scale insect virus production.
Originator: Inoue,Hajime & Mitsuhashi,Jun
A immortal cabbage moth larva-derived cell line cell that has the characteristics: Sensitive to nuclear polyhedrosis virus. Possible to grow in sea-water based low-cost medium.
A immortal cabbage moth larva-derived cell line cell that has the characteristics: Insect cell line derived from Mamestra brassicae
Derived from tissue: larval in animal: armyworm, cabbage.
A immortal cabbage moth larva-derived cell line cell that has the characteristics: Insect cell line derived from Mamestra brassicae. Cell growth is slow.
RCB0413 cell is an immortal cabbage moth larva-derived cell line cell that has the characteristics: Show finely branched cytoplasmic processes.
Derived from tissue: pupal ovary in animal: armyworm, cabbage.
RCB0278 cell is an immortal cabbage moth larva-derived cell line cell that has the characteristics: Show finely branched cytoplasmic processes.
A immortal cabbage moth larva-derived cell line cell that has the characteristics: Susceptible to insect viruses.
Derived from tissue: fat body in animal: armyworm, common.
A immortal monkey kidney-derived cell line cell that has the characteristics: Highly susceptible to SV40 infection
Derived from tissue: kidney in animal: monkey, African green.
A immortal monkey kidney-derived cell line cell that has the characteristics: 35 copies of CAG-loxP-neopA-loxP-LacZ were tandemly inserted. Cre will delete neopA and induce LacZ.
RCB0539 cell is an immortal monkey kidney-derived cell line cell that has the characteristics: SV40 large T antigen expressing, derived from CV-1.
A immortal monkey kidney-derived cell line cell that has the characteristics: A copy of CAG-loxP-neopA-loxP-LacZ was inserted. Cre will delete neopA and induce LacZ.
A immortal monkey kidney-derived cell line cell that has the characteristics: CAG-loxP-neopA-loxP-LacZ(incomplete) was inserted. Control cell line for 2-2 and 2-7 cells.
A immortal monkey kidney-derived cell line cell that has the characteristics: Expressing SV40 tsA58 large T antigen. Possible to culture in protein-free MEM. G418-resistant.
A immortal monkey kidney-derived cell line cell that has the characteristics: Expressing SV40 tsA58 large T antigen. Verots S3 cultured in protein-free MEM. G418-resistant.
A immortal monkey kidney-derived cell line cell that has the characteristics: Culturable in proein-free MEM supplemented with biotin.
RCB0143 cell is an immortal monkey kidney-derived cell line cell that has the characteristics: SV40 large T antigen expressing, derived from CV-1.
A immortal monkey kidney-derived cell line cell that has the characteristics: No interferon production, best for vaccine product.
A immortal monkey kidney-derived cell line cell that has the characteristics: Subline of COS cell line expressing Fucci, a marker of cell cycle.
A immortal monkey kidney-derived cell line cell that has the characteristics: Cynomolgus monkey cell line. Possible to culture in DMEM medium. See RCB0456.
Derived from tissue: kidney in animal: monkey, cynomolgus.
A immortal monkey kidney-derived cell line cell that has the characteristics: Cynomolgus monkey cell line.
A mouse x rat hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against mouse B7-H1.
Derived from tissue: hybridoma in animal: mouse x rat.
A mouse x rat hybridoma cell line cell that has the characteristics: Hybridoma producing a monoclonal antibody against mouse B7-H1. Possible to culture in RPMI1640 medium.
RCB2309 cell is a mouse x rat hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against GFP. Rat IgG2a monoclonal antibody.
RCB2311 cell is a mouse x rat hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against GFP. Rat IgG2a monoclonal antibody.
A mouse x rat hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against bacterial unknown molecule. Rat IgG2a monoclonal antibody.
RCB2310 cell is a mouse x rat hybridoma cell line cell that has the characteristics: Hybridoma producing monoclonal antibody against GFP. Rat IgG2a monoclonal antibody.
A immortal mouse embryo-derived cell line cell that has the characteristics: Non-contact inhibited
Derived from tissue: embryo in animal: mouse.
A immortal mouse embryo-derived cell line cell that has the characteristics: Subline of KOP cell line. Zeocin-resistant.
A immortal mouse embryo-derived cell line cell that has the characteristics: Subline of KOP cell line, expressing FLAG-tagged EXIP. Zeocin-resistant.
A immortal mouse embryo-derived cell line cell that has the characteristics: Subline of KOP cell line, expressing FLAG-tagged p38 MAP kinase. Zeocin-resistant.
A immortal mouse embryo-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line lacking p38 MAP kinase expression.
A immortal mouse embryo-derived cell line cell that has the characteristics: Tioguanine- and ouabain-resistant and HAT-sensitive fibroblasts. Suitable for ES cell feeder layer. Back up culture of ECA85061804.
A immortal mouse embryo-derived cell line cell that has the characteristics: RBP-J deficient mouse fibroblasts
A immortal mouse embryo-derived cell line cell that has the characteristics: Control cell line for OT11 (normal fibroblasts derived from the same mouse strain)
A immortal mouse embryo-derived cell line cell that has the characteristics: Mouse teratoma-derived cell line. Parent cell line of ATDC5.
Derived from tissue: embryo in animal: mouse, 129.
RCB2314 cell is an immortal mouse embryo-derived cell line cell that has the characteristics: Mouse cell line derived from embryonal carcinoma. Expressing laminin alpha-5 exogenously.
Originator: Hayashi, Yoshitake (Nagoys Univ.)
RCB2315 cell is an immortal mouse embryo-derived cell line cell that has the characteristics: Mouse cell line derived from embryonal carcinoma. Expressing laminin alpha-5 exogenously.
A immortal mouse embryo-derived cell line cell that has the characteristics: Differentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
A immortal mouse embryo-derived cell line cell that has the characteristics: Mouse cell line derived from embryonal carcinoma. 129 strain. TKG0519(Deposited from Tohoku Univ.).
A immortal mouse embryo-derived cell line cell that has the characteristics: Mouse teratoma-derived cell line.
A immortal mouse embryo-derived cell line cell that has the characteristics: Said to differentiate to parietal endoderm with retinoic acid and dibutyryl cAMP.
A immortal mouse embryo-derived cell line cell that has the characteristics: A subline of mouse ES cell line, F9 (129), lacking Odf2.
A immortal mouse embryo-derived cell line cell that has the characteristics: Siblings of RGB3T3-1, contact-inhibited
Derived from tissue: embryo in animal: mouse, BALB/c.
A immortal mouse embryo-derived cell line cell that has the characteristics: Contact-inhibited semi-normal cell line
Originator: Aaronson, S.A. & Todaro, G.T.
A immortal mouse embryo-derived cell line cell that has the characteristics: Original cloned line from RCB, just like BALB/3T3
A immortal mouse embryo-derived cell line cell that has the characteristics: Mouse cell line derived from embryonal carcinoma. C3H strain. Following differentiation, beating cardiomyocytes appear. The efficiency of differentiation is lower compared to RCB 2318.
Derived from tissue: embryonal carcinoma in animal: mouse, C3H.
A immortal mouse embryo-derived cell line cell that has the characteristics: Mouse cell line derived from embryonal carcinoma. C3H strain. Following differentiation, beating cardiomyocytes appear efficiently.
A immortal mouse embryo-derived cell line cell that has the characteristics: Clone 8, Contact-inhibited semi-normal
Derived from tissue: embryo in animal: mouse, C3H.
A immortal mouse embryo-derived cell line cell that has the characteristics: Subline of A-6. Dependent on SCF and IL-6 for proliferation. Differentiate to erythroid cells by IL-3.
A immortal mouse embryo-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line. TKG0299 (Deposited from Tohoku Univ.).
Derived from tissue: embryo in animal: mouse, NIH Swiss.
A immortal mouse embryo-derived cell line cell that has the characteristics: Spontaneous transformant of NIH3T3
A immortal mouse embryo-derived cell line cell that has the characteristics: SV40 large T (tsA58)-pBR322 tarnsformed NIH3T3.
Originator: Ohno, Tadao & Abe, Shin-ichiro
A immortal mouse embryo-derived cell line cell that has the characteristics: NIH3T3 transformant expressing human activated k-ras-2.
A immortal mouse embryo-derived cell line cell that has the characteristics: pSV2neo-introduced G418-resistant Cle-H3 mutant.
A immortal mouse embryo-derived cell line cell that has the characteristics: Subclone of NIH3T3
A immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus. A subline of ψCRIP.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse GM-CSF cDNA
A immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus including mouse IL-1alpha cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus including mouse IL-1 receptor antagonist cDNA
A immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus including mouse IL-2 cDNA
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse IL-3 cDNA
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse IL-6 cDNA
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse IL-7 cDNA
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse IL-10 cDNA
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse IL-12 cDNA for p40 subunit. Refer RCB1099.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse IL-12 cDNA for p35 subunit. Refer RCB1098.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse TNF-alpha gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including human TNF-alpha cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse lymphotoxin cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse G-CSF gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including human M-CSF gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus including mouse IFN-gamma cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including human MIF cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse leukemia inhibitory factor cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse kit ligand (SCF) cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including human oncostatin M cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse B7 (CD80) cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse B7-2 (CD86) cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including the trancated form of mouse IFN-gamma cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including rabbit IL-1 receptor antagonist cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including rat GM-CSF cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including neo gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including HSV thymidine kinase cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse c-src cDNA with ts mutation.
A immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus including mouse c-src cDNA with ts mutation.
RCB1119 cell is an immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus including SV40 large T temperature-sensitive cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express human VIP receptor and blasticidin S deaminase gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Producer of MoMLV-derived retrovirus including mouse IL-4 cDNA
RCB1120 cell is an immortal mouse embryo-derived cell line cell that has the characteristics: High-titer producer of MoMLV-derived retrovirus including SV40 large T temperature-sensitive cDNA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Retrovirus producer. Produce virus to express human Bax protein.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express angiotensin receptor.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express the human CD82.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express the anti-apoptotic crmA.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express the human endothelin receptor.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express the mouse calcineurin.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express lac Z.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express SV40 large T antigen.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express human MSH receptor.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express Cre recombinase.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express human p53 and blasticidin S deaminase gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express human Bcl-xL and blasticidin S deaminase gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express human FAS and human CD80.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express human secretin receptor and blasticidin S deaminase gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express human somatostatin receptor and blasticidin S deaminase gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Cell line producing retrovirus to express a truncated form of mouse calcineurin and blasticidin S deaminase gene.
A immortal mouse embryo-derived cell line cell that has the characteristics: Subline of ψCRIP that produce virus to express LacZ possessing nuclear localization signal.
A immortal mouse embryo-derived cell line cell that has the characteristics: A subline of the NIH/3T3 cell line. Transformed lymphoblast-like cells. Swiss strain.TKG0300(Deposited from Tohoku Univ.). TKG0300(Deposited from Tohoku Univ.). Cell growth is slow.
Derived from tissue: embryo in animal: mouse, Swiss.
A immortal mouse embryo-derived cell line cell that has the characteristics: Embryonal cell line derived from wild mouse. Sensitive to leukemia viruses.
Derived from tissue: embryo in animal: mouse, wild.
A immortal rat liver-derived cell line cell that has the characteristics: Capable to form collagen network. Possible to culture in DMEM medium. See RCB0067.
Derived from tissue: liver in animal: rat.
A immortal rat liver-derived cell line cell that has the characteristics: Non tumorigenic in nude mice
A immortal rat liver-derived cell line cell that has the characteristics: Non tumorigenic in nude mice. Possible to culture in DMEM medium.
A immortal rat liver-derived cell line cell that has the characteristics: Liver-derived cell, tumorigenic in nude mice. Possible to culture in DMEM medium.
A immortal rat liver-derived cell line cell that has the characteristics: Epitherial cell from rat liver. Possible to culture in DMEM medium.
A immortal rat liver-derived cell line cell that has the characteristics: Epitherial cell from rat liver
A immortal rat liver-derived cell line cell that has the characteristics: Capable to form collagen network
A immortal rat liver-derived cell line cell that has the characteristics: Liver-derived cell, tumorigenic in nude mice
A immortal rat liver-derived cell line cell that has the characteristics: Rat cell line derived from hepatoma cells in ascites. TKG0535(Deposited from Tohoku Univ.).
Derived from tissue: liver, ascites in animal: rat , Donryu.
A immortal rat liver-derived cell line cell that has the characteristics: Rat cell line derived from hepatoma cells in ascites. TKG0130(Deposited from Tohoku Univ.).
Derived from tissue: liver, ascites in animal: rat, ACI/N.
A immortal rat liver-derived cell line cell that has the characteristics: Rat (Buffalo) cell line derived from hepatoma. TKG0365 (Deposited from Tohoku Univ.).
Derived from tissue: liver in animal: rat, Buffalo.
A immortal rat liver-derived cell line cell that has the characteristics: ES cell differentiation inhibitory activity (DIA)
RCB0450 cell is an immortal rat liver-derived cell line cell that has the characteristics: EJ-ras oncogene transformed ARLJ301-3.
Derived from tissue: liver in animal: rat, F344/DuCrj.
RCB0451 cell is an immortal rat liver-derived cell line cell that has the characteristics: EJ-ras oncogene transformed ARLJ301-3.
RCB0449 cell is an immortal rat liver-derived cell line cell that has the characteristics: EJ-ras oncogene transformed ARLJ301-3.
A immortal rat liver-derived cell line cell that has the characteristics: Spontaneous transformant of ARLJ301-3
A immortal rat liver-derived cell line cell that has the characteristics: Diploid rat liver epithelial cell line
A immortal rat liver-derived cell line cell that has the characteristics: Rat cell line derived from histiocytic sarcoma. Possessing characteristics of macrophage.
A immortal rat liver-derived cell line cell that has the characteristics: SV40-Adeno Vector transformed hepatocytes. Albumin secretion and urea synthesis were reported.
Derived from tissue: liver in animal: rat, Wistar.
A immortal human colon-derived cell line cell that has the characteristics: Colon carcinoma. CEA-positive, nude mouse-transplantable.
Derived from tissue: colon in animal: human.
A immortal human colon-derived cell line cell that has the characteristics: Human colon carcinoma. Backup of ECA86010202.
A immortal human colon-derived cell line cell that has the characteristics: Described to produce serotonin, epinephrine.
A immortal human colon-derived cell line cell that has the characteristics: Japanese colon carcinoma. Family of the patient also exhibited high risk, but not so-called HNPCC.
A immortal human colon-derived cell line cell that has the characteristics: Human cell line derived from colon cancer. Derived from ascites metastasis. TKG0457(Deposited from Tohoku Univ.). Cell growth is slow.
Derived from tissue: colon, ascites meta in animal: human.
A immortal human colon-derived cell line cell that has the characteristics: Human colon cancer cell line derived from metastasis at ovary. Moderately differentiated adenocarcinoma. Cell growth is slow.
Derived from tissue: colon, ovary meta in animal: human.
A immortal human colon-derived cell line cell that has the characteristics: CEA-producing colon adenocarcinoma. Back up culture of ECA2739. Cell growth is slow.
Derived from tissue: colon, supraclavicular meta in animal: human.
A immortal human brain-derived cell line cell that has the characteristics: Human malignant meningioma.
Derived from tissue: brain in animal: human.
Originator: Ishiwata, Isamu & Satou, Zenrou & Ishikawa, Hiroshi
A immortal human brain-derived cell line cell that has the characteristics: Human glioma separated from gliosarcoma.
A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from astrocytoma developed in a patient with NF-1 (neurofibromatosis type 1)
A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471(Deposited from Tohoku Univ.).
A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma. TKG0183(Deposited from Tohoku Univ.).
A immortal human brain-derived cell line cell that has the characteristics: Human brain derived lymphoma.
Originator: Ishiwata, I. & Sato, E. & Ishikawa, H.
A immortal human brain-derived cell line cell that has the characteristics: Glioma, S-100 Protein producing. Cell growth is slow.
A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma. TKG0453(Deposited from Tohoku Univ.).
Originator: Kanno H. (Neurosurgery, Yokohama City University).
A immortal human trophoblast cell line cell that has the characteristics: Trophoblastic cell. Producing chorionic gonadotropin, estrogen, progesterone. Cell growth is slow.
Derived from tissue: choriocarcinoma in animal: human.
A immortal human skin-derived cell line cell that has the characteristics: Normal human skin fibroblast
Derived from tissue: skin in animal: human.
A immortal human skin-derived cell line cell that has the characteristics: Normal diploid fibroblast from Japanese
A immortal human skin-derived cell line cell that has the characteristics: SV40-transformed Werner's syndrome fibroblast
A immortal human skin-derived cell line cell that has the characteristics: Ehlers-Danlos syndrome
A immortal human skin-derived cell line cell that has the characteristics: Morquio syndrome
RCB0390 cell is an immortal human skin-derived cell line cell that has the characteristics: Wilson's disease.
RCB0391 cell is an immortal human skin-derived cell line cell that has the characteristics: Wilson's disease.
RCB0393 cell is an immortal human skin-derived cell line cell that has the characteristics: Citrullinemia.
RCB0394 cell is an immortal human skin-derived cell line cell that has the characteristics: Citrullinemia.
RCB0395 cell is an immortal human skin-derived cell line cell that has the characteristics: Wilson's disease.
A immortal human skin-derived cell line cell that has the characteristics: Cockayne's syndrome
A immortal human skin-derived cell line cell that has the characteristics: Werner's syndrome
A immortal human skin-derived cell line cell that has the characteristics: Werner's syndrome, the same patient as RCB0433 WS1TKB2.
A immortal human skin-derived cell line cell that has the characteristics: Werner's syndrome, the same patient as RCB0409 WS1TKB.
A immortal human skin-derived cell line cell that has the characteristics: OTC(-), X-linked, dominant (XD)
Originator: Ohno, Tadao & Nakamura, Norimasa
A immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with breast cancer, different specimen from RCB0635
A immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual without cancer
RCB0584 cell is an immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual without cancer.
A immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with stomach cancer
RCB0587 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0590 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0596 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
A immortal human skin-derived cell line cell that has the characteristics: Control from a non-exposed individual without breast cancer but with thyroid & colon cancer.
RCB0602 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0603 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0608 cell is an immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with breast cancer.
A immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with uterus cancer
RCB0613 cell is an immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with breast cancer.
A immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor without cancer
RCB0617 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0620 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
A immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer, different specimen from RCB0624
A immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer, different specimen from RCB0621.
RCB0631 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0633 cell is an immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with breast cancer.
A immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with chest cancer
A immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual with breast cancer, different specimen from RCB0580.
A immortal human skin-derived cell line cell that has the characteristics: Tay-Sachs' disease
A immortal human skin-derived cell line cell that has the characteristics: Malignant trichilemmal cyst cells. Strongly laminin positive on cell surface. Serum-free culturable.
A immortal human skin-derived cell line cell that has the characteristics: Skin fibroblasts from a familial colon polyposis patient.
RCB0784 cell is an immortal human skin-derived cell line cell that has the characteristics: Skin fibroblasts from a familial colon polyposis patient at Hiroshima.
RCB0785 cell is an immortal human skin-derived cell line cell that has the characteristics: Skin fibroblasts from a familial colon polyposis patient at Hiroshima.
RCB0786 cell is an immortal human skin-derived cell line cell that has the characteristics: Skin fibroblasts from a familial colon polyposis patient at Hiroshima.
RCB0787 cell is an immortal human skin-derived cell line cell that has the characteristics: Skin fibroblasts from a familial colon polyposis patient at Hiroshima.
RCB0788 cell is an immortal human skin-derived cell line cell that has the characteristics: Skin fibroblasts from a familial colon polyposis patient at Hiroshima.
A immortal human skin-derived cell line cell that has the characteristics: Severe insulin-resistance by uncleaved insulin proreceptor. G->T mutation in interconnecting region.
RCB0583 cell is an immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual without cancer.
RCB0588 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0589 cell is an immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual without cancer.
RCB0604 cell is an immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor with breast cancer.
RCB0605 cell is an immortal human skin-derived cell line cell that has the characteristics: Control from a nonexposed individual without cancer.
A immortal human skin-derived cell line cell that has the characteristics: Werner's syndrome fibroblast
A immortal human skin-derived cell line cell that has the characteristics: Once thought Werner's Syndrome, but the life span in vitro was more than 50 PDL.
A immortal human skin-derived cell line cell that has the characteristics: Accelerated aging in vitro, Werner's syndrome
A immortal human skin-derived cell line cell that has the characteristics: Melanoma from a 47 year old female. Backup of ECA87061210.
A immortal human skin-derived cell line cell that has the characteristics: Human melanoma producing melanin up to 50 PDL. Backup of ECA88030401.
A immortal human skin-derived cell line cell that has the characteristics: Questionable Werner's syndrome-like. Life span in vitro was over 60 PDL.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome patient's skin. The same patient as GMC0001.
A immortal human skin-derived cell line cell that has the characteristics: Chromosomal aberration; 46XX + (11;12)(q23.3, q15). Need confirmation.
A immortal human skin-derived cell line cell that has the characteristics: Japanese cystic fibrosis fibroblast.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome patient's skin. The same patient as GMC0005.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome (questionable) patient's skin. The same patient as GMC0015.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome patient's skin. The same patient as GMC00017.
A immortal human skin-derived cell line cell that has the characteristics: Diploid fibroblast from normal Japanese skin.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome (questionable) patient's skin. The same patient as GMC0020.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome patient's skin. The same patient as GMC0029.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome patient's skin. The same patient as GMC0030.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome patient's skin. The same patient as GMC00035.
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome (questionable) patient's skin.
A immortal human skin-derived cell line cell that has the characteristics: Prader-Willi syndrome with obesity. del(15) was found in lymphocytes of the patient.
A immortal human skin-derived cell line cell that has the characteristics: Pseudo congenital lactic acidosis.
A immortal human skin-derived cell line cell that has the characteristics: Pyruvate dehydrogenase deficiency fibroblasts.
Originator: Ohno, Tadao & Saijo, Kaoru & Nakamura, Norimasa
A immortal human skin-derived cell line cell that has the characteristics: Atomic bomb survivor without breast cancer but with thyroid cancer.
A immortal human skin-derived cell line cell that has the characteristics: Normal human skin fibroblast, RCB original
A immortal human skin-derived cell line cell that has the characteristics: Human primary adherent cells derived from Werner syndrome patient's skin. The same patient as GMC0016.
RCB2066 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
Derived from tissue: skin in animal: mouse, (BALB/c x C57BL/6)F1.
RCB2065 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
RCB2067 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
RCB2068 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
RCB2072 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
RCB2073 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
RCB2071 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
RCB2070 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/c x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (BALB/cxC3H)F1 strain. Induced by ultra-violet irradiation.
Derived from tissue: skin in animal: mouse, (BALB/cxC3H)F1.
RCB2061 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (C3H/HeN x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
Derived from tissue: skin in animal: mouse, (C3H/HeN x C57BL/6)F1.
RCB2062 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. (C3H/HeN x C57BL/6)F1 strain. Induced by ultra-violet irradiation.
RCB1995 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse skin derived cell line. Induced by ultra-violet irradiation.
Derived from tissue: skin in animal: mouse, BALB/c.
RCB1996 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse skin derived cell line. Induced by ultra-violet irradiation.
RCB2026 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2027 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2028 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2030 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2031 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2032 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2033 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2034 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2035 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2036 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2057 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2058 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2059 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2060 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
RCB2029 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. BALB/c strain. Induced by ultra-violet irradiation.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line established by UV irradiation. Derived from Balb/c strain. (Neuron-like)
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line established by UV irradiation. Derived from Balb/c strain. (Epithelial-like)
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse stromal cell line for human lung small cell carcinoma cell line, WA-ht. Cell growth is slow.
Derived from tissue: skin in animal: mouse, BALB/c(nu/nu).
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. C3H/HeN strain. Induced by ultra-violet irradiation.
Derived from tissue: skin in animal: mouse, C3H/HeN.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse melanoma producing melanin.
Derived from tissue: skin in animal: mouse, C57BL/6.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse melanoma expressing E.coli lac Z. Strongly positive with beta-galactosidase.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. C57BL/6 strain. Induced by ultra-violet irradiation.
RCB1998 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse skin derived cell line. Induced by ultra-violet irradiation.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast-like cell line derived from skin. C57BL/6 strain.Induced by ultra-violet irradiation.
A immortal mouse skin-derived cell line cell that has the characteristics: Melanin pigment producing mouse melanoma
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse cell line derived from melanoma. TKG0598 (Deposited from Tohoku Univ.).
A immortal mouse skin-derived cell line cell that has the characteristics: Glucosylceramide synthetase-deficient B16 melanoma mutant.
Derived from tissue: skin in animal: mouse, C57BL/6J.
A immortal mouse skin-derived cell line cell that has the characteristics: Not expressing melanoma antigen. Control for GM-95 cell line.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse GM-CSF producing B16 melanoma.
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse cell line derived from melanoma. TKG0348 (Deposited from Tohoku Univ.).
A immortal mouse skin-derived cell line cell that has the characteristics: Mouse cell line derived from melanoma. C57BL/6J strain. TKG0347(Deposited from Tohoku Univ.).
RCB1992 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast cell line. Transformed by ultraviolet. Highly immunogenic.
Derived from tissue: skin in animal: mouse,(BALB/c×C57BL/6)(CB6)F1.
RCB1993 cell is an immortal mouse skin-derived cell line cell that has the characteristics: Mouse fibroblast cell line. Transformed by ultraviolet. Highly immunogenic.
A immortal mouse epithelial cell line cell that has the characteristics: Metastatic epithelial cell
Derived from tissue: cheek in animal: mouse, C3H.
A immortal mouse liver-derived cell line cell that has the characteristics: Hepatocytes containing temperature sensitive SV40 large T antigen. P450IA1 inducible.
Derived from tissue: liver in animal: mouse.
A immortal mouse liver-derived cell line cell that has the characteristics: Derived from BW7756 tumor in a C57L mouse. Back up culture of ECA3041.
Derived from tissue: liver in animal: mouse, C57L.
A immortal Drosophila melanogaster embryo-derived cell line cell that has the characteristics: Fruit fly Oregon-R derived cell line. Highly sensitive in RNA interference compared with CHO-K1.
Derived from tissue: embryo in animal: Drosophila.
A immortal mouse spleen-derived cell line cell that has the characteristics: Mast cell precursor, respond to IL-3
Derived from tissue: spleen in animal: mouse.
A immortal mouse spleen-derived cell line cell that has the characteristics: Spontaneous transformant of LT4
A immortal mouse spleen-derived cell line cell that has the characteristics: Mouse cell line derived from erythroleukemia cells transformed by Friend leukemia virus. TKG0370(Deposited from Tohoku Univ.).
A immortal mouse spleen-derived cell line cell that has the characteristics: Friend leukemia cell line from BALB/c mouse. Virusnon-producing.
Derived from tissue: spleen in animal: mouse, BALB/c.
RCB1849 cell is an immortal mouse spleen-derived cell line cell that has the characteristics: Erythroleukemia cell line drived from mouse C3H/He. TER119(+) cells.
Derived from tissue: spleen in animal: mouse, C3H/He.
RCB1850 cell is an immortal mouse spleen-derived cell line cell that has the characteristics: Erythroleukemia cell line drived from mouse C3H/He. TER119(+) cells.
RCB1847 cell is an immortal mouse spleen-derived cell line cell that has the characteristics: Erythroleukemia cell line drived from mouse C3H/He. TER119(+) cells.
RCB1848 cell is an immortal mouse spleen-derived cell line cell that has the characteristics: Erythroleukemia cell line drived from mouse C3H/He. TER119(+) cells.
A immortal mouse spleen-derived cell line cell that has the characteristics: Friend leukemia cell line. High ability to differentiate to erythroblastoid cells.
Derived from tissue: spleen in animal: mouse, DBA/2.
A immortal mouse spleen-derived cell line cell that has the characteristics: Friend leukemia cell line from DBA/2 mouse.
A immortal mouse spleen-derived cell line cell that has the characteristics: Mouse cell line derived from leukemia. Lymphoblastoid cells. DBA/2 strain. TKG0409(Deposited from Tohoku Univ.).
Derived from tissue: spleen, lymphnode, leukemia in animal: mouse, DBA/2.
A immortal mouse spleen-derived cell line cell that has the characteristics: Friend leukemia. Differentiate to erythroblastoid cells.
Derived from tissue: spleen in animal: mouse, DDD.
A immortal mouse spleen-derived cell line cell that has the characteristics: Friend leukemia. Differentiate to erythroblastoid cells with benzidine etc.
A immortal mouse spleen-derived cell line cell that has the characteristics: Friend leukemia. Differentiate to erythroblastoid cells with 1.5% DMSO etc. A clone of TSFAT-3.fl
A immortal mouse spleen-derived cell line cell that has the characteristics: SFFV producing Friend leukemia cell line. Non-differentiating.
A immortal mouse kidney-derived cell line cell that has the characteristics: Kidney epithelial cells containing temperature sensitive SV40 large T antigen. Compared to TKC2.
Derived from tissue: kidney in animal: mouse.
A immortal human stomach-derived cell line cell that has the characteristics: Stomach cancer, but producing hybrid type of alkaline phosphatase. See HuG1-N.
Derived from tissue: stomach in animal: human.
A immortal human stomach-derived cell line cell that has the characteristics: Stomach cancer, but producing Nagao-type alkaline phosphatase. See HuG1-PI.
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from signet ring cell carcinoma of stomach. TKG0449 (Deposited from Tohoku Univ.).
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from gastric cancer. Signet ring carcinoma. TKG0213 (Deposited from Tohoku Univ.).
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from gastric cancer. TKG0411 (Deposited from Tohoku Univ.). Cell growth is slow.
A immortal human stomach-derived cell line cell that has the characteristics: Human gastric cancer cell line. TKG0185 (Deposited from Tohoku Univ.).
A immortal human stomach-derived cell line cell that has the characteristics: Stomach cancer (Borrmann IV). Mutin, CA19-9, CEA, alphafetoprotein positive Cell growth is slow.
RIKEN: COSMIC ID:906869; Riken RCB0555,RCB0555
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from gastric cancer. Established from the cells in ascites.
Derived from tissue: stomach, ascites meta in animal: human.
A immortal human stomach-derived cell line cell that has the characteristics: Human gastric cancer cell line derived from metastasis at liver.
Derived from tissue: stomach, liver meta in animal: human.
A immortal human stomach-derived cell line cell that has the characteristics: Small cell gastrointestinal carcinoma with c-myc overexpression. Cell growth is slow.
RIKEN: COSMIC ID:906848; Riken RCB0983,RCB0983
A immortal human stomach-derived cell line cell that has the characteristics: Poorly differentiated gastric adenocarcinoma. Producing high level of CEA.
A immortal human stomach-derived cell line cell that has the characteristics: Moderately differentiated adenocarcinoma. Once they were hypodiploids. Cell growth is slow.
A immortal human stomach-derived cell line cell that has the characteristics: Gastric cancer undifferentiated, mucin producing
Derived from tissue: stomach, lymph node meta in animal: human.
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from lymph node metastasis of gastric cancer.
A immortal human stomach-derived cell line cell that has the characteristics: Japanese gastric cancer, lymph node metastated.
RIKEN: RCB1148,COSMIC ID:909770; Riken RCB1148
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from gastric cancer
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from stomach cancer.
A immortal human stomach-derived cell line cell that has the characteristics: Potentially differentiatable to both direction of adenomatous and squamous epithelial cells.
A immortal human stomach-derived cell line cell that has the characteristics: c-erbB-2 expressing gastric adenocarcinoma. Differentiated type.
A immortal human stomach-derived cell line cell that has the characteristics: Human cell line derived from intraperitoneal metastasis of gastric cancer
Derived from tissue: stomach, mesenterium meta in animal: human.
A immortal human stomach-derived cell line cell that has the characteristics: Small cell gastrointestinal carcinoma showing creatine kinase-BB and aromatic L-amino-acid decarboxy. Cell growth is slow.
Derived from tissue: stomach, subcutis in animal: human.
A immortal human bone element-derived cell line cell that has the characteristics: Osteosarcoma cell line derived from human. High yield of IFN production by induction with poly IC, cyclohexmide, actinomycin D. Antigenically, MG-63 IFN is closely related to human fibroblast IFN. TKG0294 (Deposited from Tohoku Univ.).
Derived from tissue: bone in animal: human.
A immortal human bone element-derived cell line cell that has the characteristics: Human cell line derived from osteosarcoma. TKG0451(Deposited from Tohoku Univ.).
A immortal human bone element-derived cell line cell that has the characteristics: Sensitive to further transformation with both virus and chemicals. Backup of ECA87070202.
A immortal human bone element-derived cell line cell that has the characteristics: Human osteosarcoma producing osteoid in vitro and in vivo(mouse). Cell growth is slow.
Originator: Hotta, Tetsuo & Motoyama, Teiichi
A immortal human bone element-derived cell line cell that has the characteristics: Osteoid producing in vitro and in nude mice. Cell growth is slow.
A immortal rat cell line cell that has the characteristics: Ascites hepatoma.
Derived from tissue: ascites hepatoma in animal: rat.
A immortal rat cell line cell that has the characteristics: Subclone of AH-66, lost transplantability in rats. Possible to culture in DMEM medium. See RCB0063.
A immortal rat cell line cell that has the characteristics: Ascites hepatoma. Possible to culture in DMEM medium. See RCB0065.
A immortal rat cell line cell that has the characteristics: Subclone of AH-66, lost transplantability in rats.
A immortal rat cell line cell that has the characteristics: Rat lung fibroblast once said interferon-producing. Serum-& protein-free culturable.
Derived from tissue: lung in animal: rat.
A immortal rat cell line cell that has the characteristics: Rat lung fibroblast once said interferon-producing. Possible to culture in DMEM medium. See RCB0074 .
A immortal rat cell line cell that has the characteristics: Sticky cell from lymph node.
Derived from tissue: lymph node in animal: rat.
A immortal rat cell line cell that has the characteristics: Sticky cell from lymph node. Possible to culture in DMEM medium.
A immortal rat cell line cell that has the characteristics: Pheochromocytoma, differentiate by NGF stimulation
Derived from tissue: pheochromocytoma in animal: rat.
A immortal rat cell line cell that has the characteristics: A subline of PC-12 lacking synaptotagmin-1.
A immortal rat cell line cell that has the characteristics: A subline of PC-12 expressing synaptotagmin-1, a control cell line for PC12-F7.
A immortal rat cell line cell that has the characteristics: Cell line for titration of murine leukemia virus.
Derived from tissue: rous sarcoma in animal: rat.
A immortal rat cell line cell that has the characteristics: Rat cell line derived from sarcoma cells in ascites. TKG0648(Deposited from Tohoku Univ.).
Derived from tissue: sarcoma, ascitic tumor in animal: rat.
A immortal rat cell line cell that has the characteristics: Rat small intestine epithelial cells. Backup of ECA88071401.
Derived from tissue: small intestine in animal: rat.
A immortal rat cell line cell that has the characteristics: Rat thymoma cell line without mouse chromosome contamination. Compare to MTHC-2 and -3.
Derived from tissue: thymus in animal: rat, BUF/Mna.
A immortal rat cell line cell that has the characteristics: Rat cell line derived from lung cancer. TKG0135(Deposited from Tohoku Univ.).
Derived from tissue: lung in animal: rat, Donryu.
A immortal rat cell line cell that has the characteristics: Rat cell line derived from osteosarcoma. F344 strain.
Derived from tissue: osteosarcoma in animal: rat, F344.
A immortal rat cell line cell that has the characteristics: Subline of KMY-J. Fibroblast-like
Derived from tissue: meninx in animal: rat, F344/DuCrj.
A immortal rat cell line cell that has the characteristics: Subline of KMY-J. Polyploidy
A immortal rat cell line cell that has the characteristics: Subline of KMY-J. Epithelial-like
A immortal rat cell line cell that has the characteristics: Meningioma derived cell line. Derived from rat F344.
A immortal rat cell line cell that has the characteristics: Rat fibrous histiocytoma. Acid phosphatase and nonspecific esterase are weakly positive.
Derived from tissue: subcutis of the head in animal: rat, F344/DuCrj.
A immortal rat cell line cell that has the characteristics: Rat fibrous histiocytoma. Acid phosphatase-, non-specific esterase- & monocytic antigen-positive.
A immortal rat cell line cell that has the characteristics: F344 male rat fibrosarcoma cells, but with histiocytic and/or myofibroblastic characteristics.
Derived from tissue: submandibular salivary gland in animal: rat, F344/DuCrj.
A immortal rat cell line cell that has the characteristics: A subline of NBT-II. Low invasive bladder carcinoma. Relatively high cadherin expression.
Derived from tissue: bladder in animal: rat, Wistar.
A immortal rat cell line cell that has the characteristics: A subline of NBT-II. Almost non-invasive bladder carcinoma. Relatively high cadherin expression.
A immortal rat cell line cell that has the characteristics: A subline of NBT-II. Invasive bladder carcinoma. Relatively low cadherin expression.
A immortal rat cell line cell that has the characteristics: A subline of NBT-II. Highly invasive bladder carcinoma. Relatively low cadherin expression.
A immortal rat cell line cell that has the characteristics: A subline of NBT-II. The most invasive bladder carcinoma. Relatively low cadherin expression.
A immortal rat cell line cell that has the characteristics: So called clear cells from rat stomach mucosa.
Derived from tissue: gastric mucosa in animal: rat, Wistar.
A immortal human urinary bladder-derived cell line cell that has the characteristics: Bladder transitional-cell carcinoma
Derived from tissue: bladder in animal: human.
A immortal human urinary bladder-derived cell line cell that has the characteristics: Human cell line derived from bladder cancer. Transitional cell carcinoma. TKG0443 (Deposited from Tohoku Univ.).
A immortal human urinary bladder-derived cell line cell that has the characteristics: Described to produce SCF, IL-1, IL-3, IL-6, G-CSF, GM-CSF, etc.
A immortal human urinary bladder-derived cell line cell that has the characteristics: Human cell line derived from urinary bladder carcinoma. Derived from ascites.
Derived from tissue: bladder, ascites meta in animal: human.
A immortal human urinary bladder-derived cell line cell that has the characteristics: Human cell line derived from urinary bladder carcinoma. TKG0641 (Deposited from Tohoku Univ.).
Derived from tissue: Urinary bladder in animal: human.
A immortal human liver-derived cell line cell that has the characteristics: Human liver cholangiocarcinoma. Said CEA and CA19-9 producing.
Derived from tissue: liver in animal: human.
A immortal human liver-derived cell line cell that has the characteristics: Spindle cell-type cholangiocarcinoma cell line.
A immortal human liver-derived cell line cell that has the characteristics: Said producing alpha-fetoprotein, alpha-antitrypsin, ceruloplasmin, fibrinogen, fibronectin, etc.
A immortal human liver-derived cell line cell that has the characteristics: Hepatoblastoma. Said albumin and alpha-fetoprotein producing.
A immortal human liver-derived cell line cell that has the characteristics: Human cell line derived from intrahepatic bile duct cancer. TKG0456(Deposited from Tohoku Univ.). Cell growth is slow.
A immortal human liver-derived cell line cell that has the characteristics: Human cell line derived from hepatoma. TKG0206 (Deposited from Tohoku Univ.).
A immortal human liver-derived cell line cell that has the characteristics: Human hepatoma cell line. This cell line was established from nude mouse xenograft tumor (Dr. Hirohashi., National Cancer Center, Tokyo) by Tanno, H. (Tohoku Univ., 1st Surg). AFP producing.TKG0368 (Deposited from Tohoku Univ.).
Originator: Tanno, H. (Tohoku Univ., 1st Surg)
A immortal human liver-derived cell line cell that has the characteristics: Human cell line derived from cholangiocellular carcinoma. TKG0438 (Deposited from Tohoku Univ.). Cell growth is slow.
LCL-1925
A immortal human liver-derived cell line cell that has the characteristics: hepatocellular carcinoma. Produce alpha-fetoprotein, albumin, etc. Back up of ECA2870. Almost equal to RCB0459, but the restriction is a. Information
A immortal human liver-derived cell line cell that has the characteristics: A subline of HepG2. Expressing abundant glutamine synthetase. Information
A immortal human liver-derived cell line cell that has the characteristics: Human cell line derived from hepatocyte carcinoma. TKG0205 (Deposited from Tohoku Univ.). Information
A immortal human liver-derived cell line cell that has the characteristics: Human cell line derived from cholangiocellular carcinoma. Cell growth is slow.
Derived from tissue: liver, ascites meta in animal: human.
A immortal mouse breast-derived cell line cell that has the characteristics: Topoisomerase II inhibitor VP-16 resistant FM3A mutant.
Derived from tissue: breast in animal: mouse, C3H/HeN.
A immortal dog kidney-derived cell line cell that has the characteristics: Canine kidney epithelial. Sensitive to wide range of viruses. Backup of ECA84121903.
Derived from tissue: kidney in animal: dog.
A immortal dog kidney-derived cell line cell that has the characteristics: Dog cell line derived from kidney.
A immortal cattle kidney-derived cell line cell that has the characteristics: Very flat and thin kidney epithelial cell
Derived from tissue: kidney in animal: bovine.
A immortal cattle kidney-derived cell line cell that has the characteristics: Bovine kidney-derived epithelial cell line. FBS independent for culture.
A immortal cattle kidney-derived cell line cell that has the characteristics: Kidney epithelial cell, equiv. to ATCC CRL6071
A immortal human breast-derived cell line cell that has the characteristics: Human malignant mesothelioma. CA19-9, CA125, and hyaluronic acid producing. Cell growth is slow.
Derived from tissue: breast in animal: human.
Originator: Ishiwata, I. & Ishikawa, H. & Ishioka, K.
A immortal human breast-derived cell line cell that has the characteristics: Human breast carcinoma established from an effusion.
A immortal human breast-derived cell line cell that has the characteristics: Human cell line derived from breast adenocarcinoma. TKG0479 (Deposited from Tohoku Univ.).
Derived from tissue: brest, pleural fluid in animal: human.
A immortal human spleen-derived cell line cell that has the characteristics: Human cell line derived from splenic B cell lymphoma.
Derived from tissue: spleen in animal: human.
A immortal mouse muscle cell line cell that has the characteristics: A-Jackson mouse-derived histiocyte-like cells from spontaneous sarcoma.
Derived from tissue: muscle in animal: mouse, A/J.
A immortal mouse muscle cell line cell that has the characteristics: Said differentiate to myotubes, but need confirmation. Backup of ECA91031101.
Derived from tissue: muscle in animal: mouse, C3H.
A immortal human uterus-derived cell line cell that has the characteristics: Naturally raised CDDP(cysplatin)-resistant cell line.
Derived from tissue: uterus in animal: human.
A immortal human uterus-derived cell line cell that has the characteristics: Japanese uterine endometrioid adenocarcinoma G2. Said CA125, CEA producing.
A immortal human uterus-derived cell line cell that has the characteristics: Japanese endometrioid adenocarcinoma.
Originator: Ishikawa, H. & Yasuda, M. & Yamada, K.
A immortal human uterus-derived cell line cell that has the characteristics: Human uterus endometrioid adenocarcinoma cell line.
A immortal human uterus-derived cell line cell that has the characteristics: Human uterus endometrial adenocarcinoma cell line.
A immortal human uterus-derived cell line cell that has the characteristics: Human cell line derived from uterus cancer. Endometrioid adenocarcinoma.
A immortal human uterus-derived cell line cell that has the characteristics: Uterine adenosquamous carcinoma. Said CEA and CA125 producing. Cell growth is slow.
Originator: Ishikawa, H. & Yamada, K. & Yasuda, M.
A immortal human uterus-derived cell line cell that has the characteristics: Japanese uterine carcinosarcoma. Nude mouse transplantable.
A immortal human uterus-derived cell line cell that has the characteristics: Glassy cell carcinoma from cervix. Cell growth is slow.
Derived from tissue: uterus, lymph node meta in animal: human.
A immortal human endometrium-derived cell line cell that has the characteristics: Estradiol-17 beta responsive leiomyosarcoma
Derived from tissue: endometrium in animal: human.
A immortal human endometrium-derived cell line cell that has the characteristics: Mixed Mullerian tumor.
A immortal human endometrium-derived cell line cell that has the characteristics: Endometrium-derived fibroblasts.
A immortal human endometrium-derived cell line cell that has the characteristics: So called clear cell carcinoma. Said c-erb2(+), cathepsin D(+), CA125(+).
A immortal human endometrium-derived cell line cell that has the characteristics: Expressing receptor to estrogen and prolaction. Cell growth is slow.
A immortal human endometrium-derived cell line cell that has the characteristics: Poorly differentiated adenocarcinoma. Cell growth is slow.
A immortal human endometrium-derived cell line cell that has the characteristics: Human cell line derived from endometrial adenocarcinoma. Cell growth is slow.
A immortal human endometrium-derived cell line cell that has the characteristics: Human cell line derived from endometrial stromal sarcoma.
A immortal human kidney-derived cell line cell that has the characteristics: Renal tumor cell from a Japanese. Transplantable to nude mice.
Derived from tissue: kidney in animal: human.
A immortal human kidney-derived cell line cell that has the characteristics: Kidney carcinoma from a Japanese patient. Cell growth is slow.
A immortal human kidney-derived cell line cell that has the characteristics: Scarcely found primitive neuroectodermal tumor from a Japanese kidney.
A immortal human kidney-derived cell line cell that has the characteristics: 293 cell line expressing the caspase-inhibiting CrmA gene
A immortal human kidney-derived cell line cell that has the characteristics: Human renal cell carcinoma cell line. TKG0447(Deposited from Tohoku Univ.).
An immortal human kidney-derived cell line cell that has the characteristics: Human cell line expressing SV40 large T antigen abundantly.
A immortal human kidney-derived cell line cell that has the characteristics: Japanese kidney carcinoma cells. RCB original. Cell growth is slow.
A immortal human kidney-derived cell line cell that has the characteristics: Japanese renal carcinoma cells expressing HLA-A2402. Cell growth is slow.
RCB1383 cell is an immortal human kidney-derived cell line cell that has the characteristics: Japanese renal carcinoma cells. Cell growth is slow.
RCB1198 cell is an immortal human kidney-derived cell line cell that has the characteristics: Japanese renal carcinoma cells. Cell growth is slow.
A immortal human kidney-derived cell line cell that has the characteristics: Wilms' tumor. CA125 and TPA producing.
Originator: Ono, I. & Ishiwata, I. & Ishikawa, H.
A immortal human kidney-derived cell line cell that has the characteristics: Subline of HEK293 cell line, expressing BtR175b (Cry 1Aa receptor).
A immortal human kidney-derived cell line cell that has the characteristics: Human primitive neuroectodermal tumor cell line derived from kidney.
A immortal human kidney-derived cell line cell that has the characteristics: Retroviral vector packaging cell line expressing MoMLV (Moloney murine leukemia virus) gag/pol. Production of high titer retrovirus by cotransfection of envelope and vector plasmids.
A immortal human kidney-derived cell line cell that has the characteristics: Sheared human Ad5 DNA-transformed cell line. Widely used for production of manipulated adenovirus. Back up culture of ECA2737.
A immortal mouse brain-derived cell line cell that has the characteristics: ori- SV40 DNA transformed C3H mouse brain-derived cells. GFAP+ astrocytes and GFAP- origodendrocytes
Derived from tissue: brain in animal: mouse, C3H/HeN.
A immortal mouse brain-derived cell line cell that has the characteristics: Mouse microglial cell line immortalized by a replication-deficient retroviral vector containing human c-myc gene. No significant production of infectious viral particles from MG6 cells was confirmed by bioassay using SC-1 cells.
Derived from tissue: brain in animal: mouse, C57BL/6.
RCB0871 cell is an immortal pig kidney-derived cell line cell that has the characteristics: Pig kidney (LLC-PK1) cells expressing human P-glycoproteins.
Derived from tissue: kidney in animal: pig.
RCB0872 cell is an immortal pig kidney-derived cell line cell that has the characteristics: Pig kidney (LLC-PK1) cells expressing human P-glycoproteins.
A immortal pig kidney-derived cell line cell that has the characteristics: Buck-up culture of ECA86103005. Foot & mouth disease.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Human cell line derived from cervical cancer. The cells were converted to HGPRT(-). TKG0191(Deposited from Tohoku Univ.).
Derived from tissue: cervix in animal: human.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Just like ATCC CCL 2, HeLa
A immortal human uterine cervix-derived cell line cell that has the characteristics: Suspension culturable. Useful for JIS medium inspection
A immortal human uterine cervix-derived cell line cell that has the characteristics: Protein- & lipid-free medium growing
A immortal human uterine cervix-derived cell line cell that has the characteristics: Integrating HPV16, neurosecretory granules(+)
A immortal human uterine cervix-derived cell line cell that has the characteristics: Repair deficient (mer~)
A immortal human uterine cervix-derived cell line cell that has the characteristics: MNNG-reistant HeLa.S3(Mer~) cells
RCB0505 cell is an immortal human uterine cervix-derived cell line cell that has the characteristics: MNNG-resistant HeLa.S3(Mer~) cells.
RCB0507 cell is an immortal human uterine cervix-derived cell line cell that has the characteristics: MNNG-resistant HeLa.S3(Mer~) cells.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Large cell non-keratinizing squamouse carcinoma. Stage Ib. HPV type 18 integrated.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Japanese cervix carcinoma.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Derived from a single human as TCO-1. Said CEA, CA125, TPA (+).
A immortal human uterine cervix-derived cell line cell that has the characteristics: RCB0191 HeLa.S3, that has been cultured in MEM(susp.). This line is cultured in MEM.
A immortal human uterine cervix-derived cell line cell that has the characteristics: A subline of HeLa. 6-thioguanine resistant. TKG0204 (Deposited from Tohoku Univ.).
A immortal human uterine cervix-derived cell line cell that has the characteristics: Cervical carcinoma cell line derived from human. TA-4, CA-4, TPA, placental ALP are positive. Regan isoenzyme producing. p53 normal, p51 mutation (+), HLA-A 2402/.TKG0462(Deposited from Tohoku Univ.).
A immortal human uterine cervix-derived cell line cell that has the characteristics: Human cell line derived from cervical cancer. TKG0437(Deposited from Tohoku Univ.).
A immortal human uterine cervix-derived cell line cell that has the characteristics: Human uterus squamous cell carcinoma cell line.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Human cervical cancer cell line.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Supports growth of arvovirus and measles virus. A sabuline of HeLa cell (HeLa contamination). TKG0403 (Deposited from Tohoku Univ.).
A immortal human uterine cervix-derived cell line cell that has the characteristics: Melanoma cells with melanin-granules. Cell growth is slow.
Originator: Ishiwata, I. & Kiguchi, K. & Ishikawa, H.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Thymidine kinase defective HeLa
A immortal human uterine cervix-derived cell line cell that has the characteristics: Human cell line derived from uterine cervical epidermoid carcinoma. TKG0366(Deposited from Tohoku Univ.).
A immortal human uterine cervix-derived cell line cell that has the characteristics: A subline of the HeLa cell line expressing Fucci, a cell cycle marker.
A immortal human uterine cervix-derived cell line cell that has the characteristics: A subline of the HeLa cell line expressing Fucci2, a cell cycle marker.
A immortal human uterine cervix-derived cell line cell that has the characteristics: A subline of the HeLa cells. Expressing human CD4 and Neomycin-resistant gene.
A immortal human uterine cervix-derived cell line cell that has the characteristics: A subline of the HeLa cells. Expressing human CD4 and Neomycin-resistant gene. One copy of the HIV-1 LTR (nt-138 to +80) linked to the β-galactosidase gene is integrated.
A immortal human uterine cervix-derived cell line cell that has the characteristics: A subline of the HeLa cells. HeLa cells contained stably integrated copies of the HIV-1 LTR promoter linked to a synthetic tat gene.
Originator: Barbara K. Felber & George N. Pavlakis
A immortal human uterine cervix-derived cell line cell that has the characteristics: Most famous cultured human cell line
A immortal human uterine cervix-derived cell line cell that has the characteristics: Glassy cell carcinoma. TA-4, CA125, neuron-specific enolase producing.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Keratinizing cervix squamous carcinoma, CEA(+)
Derived from tissue: cervix, lymph node meta in animal: human.
Originator: Izumi, Rikuichi & Kawabata, Masakiyo
A immortal human uterine cervix-derived cell line cell that has the characteristics: Japanese cervix squamous cell carcinoma. Once said TA-4 positive.
Derived from tissue: cervix, Virchow's lymph node in animal: human.
A immortal human uterine cervix-derived cell line cell that has the characteristics: Mother of a Down's syndrome child. 46XX,t(2/q2/q)
Originator: Ishiwata, Isamu & Ishikawa, Hiroshi
A immortal rat pituitary gland-derived cell line cell that has the characteristics: Estrogen-induced pituitary tumor. Compared with MtT/S, MtT/SM, and MtT/Se.
Derived from tissue: pituitary in animal: rat, F344.
A immortal rat pituitary gland-derived cell line cell that has the characteristics: Growth hormone, prolactine producing
Derived from tissue: pituitary in animal: rat, Fischer.
A immortal rat pituitary gland-derived cell line cell that has the characteristics: Estrogen-induced tumor. Growth hormone producing.
A immortal rat pituitary gland-derived cell line cell that has the characteristics: Estradiol-dependent pituitary tumor
A immortal mouse urinary bladder-derived cell line cell that has the characteristics: Murine transitional cell carcinoma induced by FANFT
Derived from tissue: bladder in animal: mouse.
A immortal human thyroid gland-derived cell line cell that has the characteristics: Secretes IL-1,TGFα,KGM-CSF but not thyroglobulin
Derived from tissue: thyroid in animal: human.
A immortal human thyroid gland-derived cell line cell that has the characteristics: Serum-free, protein-free cultured HOTHC cells
A immortal human thyroid gland-derived cell line cell that has the characteristics: G-CSF producing thyroidal squamous carcinoma.
A immortal human thyroid gland-derived cell line cell that has the characteristics: Human thyroid anaplastic carcinoma derived cell line. TKG0446 (Deposited from Tohoku Univ.).
A immortal human thyroid gland-derived cell line cell that has the characteristics: Thyroid tumor. TAF, G-CSF, colloid producing.
A immortal human thyroid gland-derived cell line cell that has the characteristics: Human cell line derived from thyroid cancer. Poorly differentiated papillary adenocarcinoma. TKG0439(Deposited from Tohoku Univ.).
Derived from tissue: thyroid gland in animal: human.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Subline of mouse C127 cell line. Inducible expression of influenza virus protein (PB1, NP, PA, PB2) is possible.
Derived from tissue: mammary in animal: mouse.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Subline of mouse C127 cell line. Inducible expression of influenza virus protein (PB1, NP, PA) is possible.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: A subline of C127. PB1 RNA polymerase subunit and nucleoprotein are inducible by dexamethasone.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Host for bovine papiloma virus
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Mammary tumor cell line without C-type virus
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Mouse cell line derived from mammary carcinoma. TKG0597 (Deposited from Tohoku Univ.).
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Mouse cell line derived from mammary carcinoma. Expressing human MUC1 (APR-MUC1) exogenously. TKG0595 (Deposited from Tohoku Univ.).
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Subline of mouse C127 cell line. Inducible expression of influenza virus protein (PB1, NP) is possible. Cell growth is slow.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Temperature-sensitive at chromosome condensation
Derived from tissue: mammary in animal: mouse, C3H.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Temperature-sensitive, forms multiple nuclei
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Temperature-sensitive at DNA polymerase
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Mammary carcinoma, grow in vitro and in vivo
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Newcastle disease virus resistant
Derived from tissue: mammary in animal: mouse, C3H/HeN.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: Murine mammary tumor cell lines. .Higher incidence in lung metastasis.
Derived from tissue: mammary in animal: mouse, JYG.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: murine mammary tumor cell lines. High level MMTV producer line.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: A subline of the NMuMG cell line expressing Fucci, a cell cycle marker.
Derived from tissue: mammary gland in animal: mouse, NAMRU.
A immortal mouse mammary gland-derived cell line cell that has the characteristics: A subline of the NMuMG cell line expressing Fucci2, a cell cycle marker.
A immortal human blood cell line cell that has the characteristics: Bovine derived lymphocyte.
Derived from tissue: peripheral blood lymphocytes in animal: bovine, Holstein-Friesian cow.
A immortal human blood cell line cell that has the characteristics: Human cell line derived from B cell leukemia. TKG0413(Deposited from Tohoku Univ.).
Derived from tissue: blood in animal: human.
A immortal human blood cell line cell that has the characteristics: T cell leukemia
A immortal human blood cell line cell that has the characteristics: Differentiate to granulocytes and monocytes
A immortal human blood cell line cell that has the characteristics: IL-2 dependent ATL cell line. HTLV-1 pro-virus DNA(+).
A immortal human blood cell line cell that has the characteristics: Chronic myelogeneous leukemia, subclone of RCB0495 KU812.
A immortal human blood cell line cell that has the characteristics: APRT(-) EB transformed B cell line
A immortal human blood cell line cell that has the characteristics: Acute lymphatic leukemia
A immortal human blood cell line cell that has the characteristics: Hydrogen peroxide resistant HL60-derived clone.
A immortal human blood cell line cell that has the characteristics: Human T cell line, the same patient as JM. IL-2 productivity of this line was undetermined.
A immortal human blood cell line cell that has the characteristics: B-lineage acute lymphoblastic leukemia.
A immortal human blood cell line cell that has the characteristics: A subclone of RCB1180 Tanoue.
A immortal human blood cell line cell that has the characteristics: RCB1181 ST cells transformed with human G-CSF receptor cDNA. Responds to G-CSF.
A immortal human blood cell line cell that has the characteristics: AML with Ph' chromosome and t(3;3)(q21;q26). Expressing EVI-1 and BCR/ABL mRNA.
A immortal human blood cell line cell that has the characteristics: Acute myeloid leukemia with dek/can chimera mRNA expression. Responding to G-CSF and differentiate.
RCB1438 cell is an immortal human blood cell line cell that has the characteristics: B95-8 EB virus transformed (originally normal) B cell line.
A immortal human blood cell line cell that has the characteristics: Adult T-cell leukemia. HTLV-1 pro-virus DNA(+).
RCB1487 cell is an immortal human blood cell line cell that has the characteristics: B95-8 EB virus transformed (originally normal) B cell line.
A immortal human blood cell line cell that has the characteristics: Hydrogen peroxide resistant HL60-derived clone. More resistant than HP50-2.
A immortal human blood cell line cell that has the characteristics: Human cell line derived from T cell leukemia. TKG0199(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Chronic myelogeneous leukemia, Ph1 chromosome (+),basophi-like cells.
A immortal human blood cell line cell that has the characteristics: Human myeloid leukemia cell line with chromosome 18 trisomy and mutation in DCC gene. Cell growth is slow.
A immortal human blood cell line cell that has the characteristics: Burkitt's lymphoma. Sensitive to lymphokine-activated killer cells but resistant to natural killer cells. Back up culture of ECA3011.
A immortal human blood cell line cell that has the characteristics: T cell leukemia, the same patient as RCB1164 MOLT-3.
A immortal human blood cell line cell that has the characteristics: Buck-up culture of ECA86010201. Human T cell line with the ability to grow HIV, the same patient as Jurkat.
A immortal human blood cell line cell that has the characteristics: Human T leukemic cell line (CD4+). CR2 receptor (+). TKG0229(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Burkitt's lymphoma. Sensitive to LAK cells but resistant to NK cells. Back up of culture ECA2673. Resistant to VSV. This cell line carries the latent Epstein-Barr Virus (EBV) genome and is positive for EBNA. RAJI is sometimes referred to as a 'non-producer'; the EBV genome carries deletions attributed to preventing the formation of virus particles.
A immortal human blood cell line cell that has the characteristics: Eosinophilic leukemia. Differenciate by n-butylate treatment. The same patient as RCB2142 EoL-3.
A immortal human blood cell line cell that has the characteristics: Human cell line derived from eosinophilic leukemia. The same patient as RCB0641 EoL-1 cell.
A immortal human blood cell line cell that has the characteristics: Human cell line derived from acute monocytic leukemia. Activeated macrophage activity (+), obtained from long passage of THP-1 (RCB1189 THP-1) cell line. TKG0296(Deposited from Tohoku Univ.).
Originator: Tominaga, T. (1st. Dep. Surg., Tohoku U.).
A immortal human blood cell line cell that has the characteristics: Differentates to macrophage-like cells after treatment with phorbol ester. The variant subline (RCB2128 A-THP-1).
A immortal human blood cell line cell that has the characteristics: Chronic myelogenous leukemia , subclone of RCB0495 KU812.
A immortal human blood cell line cell that has the characteristics: Human T cell leukemia. IL-2 receptor (-). Progeny were cured by Treatments with BM Cycline and MC210. TKG0209 (Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from basophilic leukemia cells. Progeny were cured by Treatments with BM Cycline and MC210. KG0304 (Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: B95-8 EB virus transformed leukemia cell line.
A BALL-1 cell line that is stored in Japan RIKEN cell bank.
A BALL-1 cell line that is stored in Japan RIKEN cell bank. TKG0467 (Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Variant of HL60. Resistant to retinoic acid and active Vit. D derivatives.
A immortal human blood cell line cell that has the characteristics: Human T cell leukemia (derivative of KE-37) . originally described to be established from the peripheral blood of a 61-year-old man with T cell chronic lymphocytic leukemia (CLL) in 1977; ; KE-37 was established from a 27-year-old man with acute lymphoblastic leukemia (ALL) in 1979
Derived from tissue: blood, T-cell leukemia in animal: human.
A immortal human blood cell line cell that has the characteristics: Human T cell leukemia, the same patient as RCB0206 MOLT-4.
A immortal human blood cell line cell that has the characteristics: Human myeloma cell.
Derived from tissue: peripheral blood in animal: human.
A immortal human blood cell line cell that has the characteristics: Human cell line derived from T cell of a patient with Sezary syndrome. Producing IL-2. TKG0375(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from T cell leukemia. TKG0463(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from T cell leukemia. TKG0385(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human B cells transformed by Epstein-Barr virus. RCB2541 is derived from the same patient. TKG0611(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from B cells of healthy volunteer. Transformed by EB virus. RCB2083 is derived from the same patient. TKG0634(TKG0499)(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from B cells of healthy volunteer. Transformed by EB virus. TKG0610(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human B cells transformed by Epstein-Barr virus. TKG0609(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from B cells of healthy volunteer. Transformed by EB virus. TKG0616(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from Bloom syndrome patient. Transformed by EBV. Can express certain antigen on the cell surface, such as cancer-specific antigen.
A immortal human blood cell line cell that has the characteristics: EBV-transformed cell line from a patient (male) with p53 germ line mutation. Mutation was noted at codon 242 (TGC→TAC) by FASAY.TKG0506 (Deposited from Tohoku Univ.).
Originator: Kudo, T. and Ishioka, C. (IDAC)
A immortal human blood cell line cell that has the characteristics: Human B cells derived from a patient of xeroderma pigmentosum. Transformed by Epstein-Barr virus. TKG0311(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: Human cell line derived from B cells of Xeroderma pigmentosum (XP) patient. Transformed by EB virus. TKG0314(Deposited from Tohoku Univ.).
A immortal human blood cell line cell that has the characteristics: IgM (lambda) secreting B cell line. Established from peripheral blood lymphocytes of apparently normal 33-y-o male. HLA profile: A2, Aw33, B7, B14.TKG0464(Deposited from Tohoku Univ.)
A immortal human blood cell line cell that has the characteristics: Human cell line derived from erythroblastic leukemia.
A immortal human blood cell line cell that has the characteristics: Rat cell line derived from basophilic leukemia cells. TKG0321 (Deposited from Tohoku Univ.).
Derived from tissue: peripheral blood in animal: rat.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Bone marrow stroma cell-derived
Derived from tissue: bone marrow in animal: mouse, BALB/c.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse cell line derived from bone marrow. Fibroblast-like cells. BALB/c strain. TKG0355(Deposited from Tohoku Univ.).
Derived from tissue: bone marrow, tibia femur in animal: mouse, BALB/c.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse cell line derived from bone marrow. Fibroblast-like. BudR resistant. BALB/c strain. TKG0356(Deposited from Tohoku Univ.).
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse bone marrow derived fibroblast-like cells line. Differentiates to neuron.
Derived from tissue: bone marrow in animal: mouse, C3H/He.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse bone marrow-derived stromal cells.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse multipotent mesenchymal cells. Derived from bone marrow.
RCB2112 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C3H/He.
RCB2113 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C3H/He.
RCB2115 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C3H/He.
RCB2147 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C3H/He.
RCB2322 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C3H/He.
RCB2323 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C3H/He.
RCB2114 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C3H/He.
RCB1534 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Bone marrow stroma cell line, depositing calcified matrix on the culture surface. Cell growth is slow.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Bone marrow stroma cell line, depositing calcified matrix on the culture surface.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Osteoclast-like cell line derived from mouse (C3H/He). Cell growth is slow.
RCB1537 cell is an immortal mouse bone marrow-derived cell line cell that has the characteristics: Bone marrow stroma cell line, depositing calcified matrix on the culture surface. Cell growth is slow.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse IL-3 dependent cells cloned from 32D. Differentiate with G-CSF stimulation.
Derived from tissue: bone marrow in animal: mouse, C3H/HeJ.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Subclone of 32D cell line. Differentiate to mature granulocytes by G-CSF.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: IL-3 dependent cells from Friend leukemia virus-infected mouse bone marrow.
A immortal mouse bone marrow-derived cell line cell that has the characteristics: Mouse mesenchymal cell line derived from bone marrow. C57/B6.
Derived from tissue: bone marrow in animal: mouse, C57/B6.
A immortal mouse aorta-derived cell line cell that has the characteristics: Mouse cell line derived from aorta of p53-deficient mouse. Epithelial like.
Derived from tissue: aorta in animal: mouse, C57BL/CBA.
A immortal human B cell line cell that has the characteristics: B lymphocyte isolated from Japanese adenosquamous carcinoma.
Derived from tissue: B cell (uterus) in animal: human.
A immortal human B cell line cell that has the characteristics: B lymphocytes isolated from a colon adenocarcinoma.
Derived from tissue: B cell, (colon) in animal: human.
Originator: Ishikawa, H. & Tabei, I. & Kubo, H.
A immortal human B cell line cell that has the characteristics: Human B cell-like cell line derived from colon adenocarcinoma tisuue.
HSC0005 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0008 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0010 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0011 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0012 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0014 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0015 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0018 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0020 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0021 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0022 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0023 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0024 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0025 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0026 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0029 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0031 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0032 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0033 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0034 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0035 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0036 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0039 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0040 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0042 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0043 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0044 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0045 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0047 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0048 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0049 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0050 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0051 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0052 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0053 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0054 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0055 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0057 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0058 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0059 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0060 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0062 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0064 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0065 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0066 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0067 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0068 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0069 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0071 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0072 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0073 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0074 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0075 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0076 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0077 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0078 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0079 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0080 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0081 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0082 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0084 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0086 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0088 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0089 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0090 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0092 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0093 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0094 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0095 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0096 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0099 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0100 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0098 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0097 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0102 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0103 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0104 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0105 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0110 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0085 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0101 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0041 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0083 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0004 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0109 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0106 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0001 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0002 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0003 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0006 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0007 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0009 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0013 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0017 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0019 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0027 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0028 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0030 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HSC0112 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0113 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0114 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0115 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0046 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0117 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0118 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0119 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0120 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0111 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0121 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0122 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0123 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0125 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0126 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0127 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0124 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0129 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0128 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0130 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0132 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0133 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0134 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0135 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0137 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0138 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0140 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0136 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0142 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0145 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0143 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America. The two B cell lines HSC0087 (WY077) and HSC0091 (WYO071) have identical similar STR patterns.
HSC0149 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0144 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0146 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0148 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0151 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0152 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0155 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0156 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0158 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HEV0064 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0074 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0078 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0109 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0131 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0203 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0262 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0312 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0345 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0399 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HSC0153 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0154 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0157 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0159 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HEV0096 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0126 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0284 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0330 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0336 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0375 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0401 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0469 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06, B*39:01 B*40:02, C*03:04 C*07:02, DRB1*08:02 DRB1*14:06, DQB1*03:01 DQB1*03:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*31:01 A*33:03, B*40:03 B*44:03, C*03:04 C*14:03, DRB1*04:05 DRB1*08:03, DQB1*04:01 DQB1*06:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*26:03, B*40:01 B*55:02, C*01:02 C*03:03, DRB1*04:05 DRB1*11:01, DQB1*03:01 DQB1*04:01, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:02, B*07:02 B*13:01, C*03:04 C*07:02, DRB1*01:01 DRB1*12:02, DQB1*03:01 DQB1*05:01, DPB1*02:02 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:01, B*48:01 B*52:01, C*08:03 C*12:02, DRB1*14:07 DRB1*15:02, DQB1*05:02 DQB1*06:01, DPB1*09:01 DPB1*14:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:03, B*15:01 B*59:01, C*01:02 C*03:03, DRB1*04:05 DRB1*15:01, DQB1*04:01 DQB1*06:02, DPB1*02:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*13:01 B*40:02, C*03:04 , DRB1*04:10 DRB1*12:02, DQB1*03:01 DQB1*04:02, DPB1*05:01 DPB1*13:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*02:10, B*39:01 B*40:06, C*07:02 C*08:01, DRB1*14:03 DRB1*15:01, DQB1*03:01 DQB1*06:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*52:01, C*12:02, DRB1*15:01 DRB1*15:02, DQB1*06:01 DQB1*06:02, DPB1*02:01 DPB1*14:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*26:01, B*07:02 B*15:01, C*03:04 C*07:02, DRB1*04:05 DRB1*14:01, DQB1*04:01 DQB1*05:02, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*54:01 B*67:01, C*01:02 C*07:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*05:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:03, B*15:01 B*40:06, C*03:03 C*15:02, DRB1*08:02 DRB1*09:01, DQB1*03:03 DQB1*04:02, DPB1*02:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*54:01, C*01:02, DRB1*04:05, DQB1*04:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*13:01 B*51:01, C*03:04 C*15:02, DRB1*04:01 DRB1*12:02, DQB1*03:01, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:03, B*15:01 B*51:01, C*03:03 C*14:02, DRB1*11:01 DRB1*15:02, DQB1*03:01 DQB1*06:01, DPB1*09:01 DPB1*13:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*35:01 B*51:01, C*04:01 C*14:02, DRB1*04:05 DRB1*09:01, DQB1*03:03 DQB1*04:01, DPB1*02:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*07:02 B*35:01, C*03:03 C*07:02, DRB1*01:01 DRB1*08:02, DQB1*04:02 DQB1*05:01, DPB1*02:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:01, B*40:01 B*40:03, C*03:04, DRB1*04:05 DRB1*13:01, DQB1*04:01 DQB1*06:03, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*02:07, B*07:02 B*46:01, C*01:02 C*07:02, DRB1*01:01 DRB1*09:01, DQB1*03:03 DQB1*05:01, DPB1*03:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*02:07, B*40:01, B*46:01, C*01:02 C*03:04, DRB1*08:03 DRB1*15:01, DQB1*06:01 DQB1*06:02, DPB1*02:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*40:02 B*59:01, C*01:02 C*03:03, DRB1*04:01 DRB1*13:02, DQB1*03:01 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*46:01 B*55:02, C*01:02, DRB1*08:03, DRB1*15:01, DQB1*06:01 DQB1*06:02, DPB1*02:01 DPB1*02:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*33:03, B*44:03 B*59:01, C*01:02 C*14:03, DRB1*04:05 DRB1*13:02, DQB1*04:01 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*51:01 B*52:01, C*12:02 C*14:02, DRB1*14:03 DRB1*15:02, DQB1*03:01 DQB1*06:01, DPB1*05:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*35:01 B*54:01, C*01:02 C*08:01, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*03:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*26:02 A*33:03, B*40:06 B*44:03, C*08:01 C*14:03, DRB1*08:02 DRB1*09:01, DQB1*03:02 DQB1*03:03, DPB1*03:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*40:02 B*51:01, C*03:04 C*14:02, DRB1*08:02 DRB1*14:03, DQB1*03:01 DQB1*03:02, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*39:01 B*48:01, C*03:03 C*07:02, DRB1*08:03 DRB1*14:01, DQB1*05:03 DQB1*06:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*31:01, B*15:11, C*03:03, DRB1*09:01, DQB1*03:03, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*26:03 A*33:03, B*15:01 B*44:03, C*03:03 C*14:03, DRB1*13:02 DRB1*14:06, DQB1*03:01 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*35:01 B*52:01, C*08:01 C*12:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*04:02 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*33:03, B*39:01 B*44:03, C*07:02 C*14:03, DRB1*04:05 DRB1*13:02, DQB1*04:01 DQB1*06:04, DPB1*03:01 DPB1*04:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*35:01 B*52:01, C*03:03 C*12:02, DRB1*12:01 DRB1*15:02, DQB1*03:01 DQB1*06:01 , DPB1*05:01 DPB1*06:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*31:01, B*40:01 B*52:01, C*03:04 C*12:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*05:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*07:02 B*56:01, C*04:01 C*07:02, DRB1*01:01 DRB1*09:01, DQB1*03:03 DQB1*05:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:01, B*39:04 B*54:01, C*01:02 C*07:02, DRB1*04:03 DRB1*04:05, DQB1*03:02 DQB1*04:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*39:01 B*52:01, C*07:02 C*12:02, DRB1*08:02 DRB1*15:02, DQB1*04:02 DQB1*06:01, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*07:02 B*51:01, C*07:02 C*14:02, DRB1*01:01 DRB1*09:01, DQB1*03:03 DQB1*05:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*33:03, B*40:02 B*44:03, C*03:04 C*14:03, DRB1*08:03 DRB1*13:02, DQB1*06:01 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*33:03, B*44:03 B*52:01, C*12:02 C*14:03, DRB1*13:02 DRB1*15:01, DQB1*06:02 DQB1*06:04, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*07:02 B*55:02, C*03:03 C*07:02, DRB1*01:01 DRB1*09:01, DQB1*03:03 DQB1*05:01, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*52:01 B*54:01, C*01:02 C*12:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*05:01 DPB1*09:01
HEV0089 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*02:07, B*15:18 B*46:01, C*01:03 C*08:01, DRB1*09:01 DRB1*12:01, DQB1*03:01 DQB1*03:03, DPB1*05:01.
HEV0091 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*02:07, B*15:18 B*46:01, C*01:03 C*08:01, DRB1*09:01 DRB1*12:01, DQB1*03:01 DQB1*03:03, DPB1*05:01.
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*54:01, C*01:02 C*03:04, DRB1*04:05 DRB1*14:01, DQB1*04:01 DQB1*05:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*07:02 B*48:01, C*07:02 C*08:01, DRB1*01:01 DRB1*09:01, DQB1*03:01 DQB1*05:01, DPB1*04:02 DPB1*13:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*11:01 B*15:01 B*54:01, C*01:02 C*04:01, DRB1*04:05 DRB1*04:06, DQB1*03:02 DQB1*04:01, DPB1*02:01 DPB1*03:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:01, B*48:01 B*59:01, C*01:02 C*08:03, DRB1*04:05 DRB1*09:01, DQB1*03:03 DQB1*04:01, DPB1*02:01 DPB1*19:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*51:01 B*54:01, C*01:02 C*14:02, DRB1*04:05 DRB1*11:01, DQB1*03:01 DQB1*04:01, DPB1*02:01DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*33:03, B*44:03 B*54:01, C*01:02 C*14:03, DRB1*04:05 DRB1*08:03, DQB1*04:01 DQB1*06:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*35:01 B*52:01, C*12:02 C*15:02, DRB1*14:06 DRB1*15:02, DQB1*03:01 DQB1*06:01, DPB1*05:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*33:03, B*44:03 B*56:01, C*04:01 C*14:03, DRB1*04:05 DRB1*09:01, DQB1*03:03 DQB1*04:01, DPB1*02:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*01:01 A*26:01, B*37:01 B*39:01, C*06:02 C*07:02, DRB1*01:01 DRB1*10:01, DQB1*05:01, DPB1*02:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:10 A*24:02, B*40:06 B*52:01, C*08:01 C*12:02, DRB1*14:05 DRB1*15:02, DQB1*05:03 DQB1*06:01, DPB1*02:02 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:01, B*35:01 B*40:02, C*03:04 C*08:01, DRB1*04:10 DRB1*09:01, DQB1*03:03 DQB1*04:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*07:02 B*56:01, C*04:01 C*07:02, DRB1*01:01 DRB1*04:05, DQB1*04:01 DQB1*05:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*33:03, B*07:02 B*44:03, C*07:02 C*14:03, DRB1*01:01 DRB1*13:02, DQB1*05:01 DQB1*06:04, DPB1*04:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*46:01 B*67:01, C*01:02 C*07:02, DRB1*08:03 DRB1*09:01, DQB1*03:03 DQB1*06:01, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*26:01, B*40:02 B*54:01, C*01:02 C*03:04, DRB1*09:01 DRB1*15:01, DQB1*03:03 DQB1*06:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*31:01 A*33:03, B*48:01 B*58:01, C*03:02 C*08:01, DRB1*09:01 DRB1*13:02, DQB1*03:03 DQB1*06:09, DPB1*03:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*26:02, B*07:02 B*52:01, C*07:02 C*12:02, DRB1*01:01 DRB1*15:02, DQB1*05:01 DQB1*06:01, DPB1*04:02 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*40:01 B*40:06, C*07:02 C*08:01, DRB1*04:06 DRB1*09:01, DQB1*03:02 DQB1*03:03, DPB1*02:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*15:18 B*52:01, C*08:01 C*12:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*26:01, B*15:01 B*52:01, C*12:02 C*15:02, DRB1*09:01 DRB1*15:02, DQB1*03:03 DQB1*06:01, DPB1*03:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*40:01 B*67:01, C*03:04 C*07:02, DRB1*12:01 DRB1*15:01, DQB1*03:01 DQB1*06:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*33:03, B*15:18 B*44:03, C*08:01 C*14:03, DRB1*04:03 DRB1*13:02, DQB1*03:02 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*39:01 B*55:02, C*01:02 C*07:02, DRB1*04:05 DRB1*08:03, DQB1*04:01 DQB1*06:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*40:02 B*59:01, C*01:02 C*03:04, DRB1*04:05 DRB1*09:01, DQB1*03:03 DQB1*04:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*33:03, B*35:01 B*44:03, C*03:03 C*14:03, DRB1*04:05 DRB1*15:01, DQB1*04:01 DQB1*06:02, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*54:01 B*59:01, C*01:02, DRB1*04:05 DQB1*04:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*39:04 B*40:02, C*03:04 C*07:02, DRB1*04:06 DRB1*09:01, DQB1*03:02 DQB1*03:03, DPB1*02:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:20 A*33:03, B*44:03 B*51:01, C*14:02 C*14:03, DRB1*09:01 DRB1*12:01, DQB1*03:02 DQB1*03:03, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*15:28 B*52:01, C*03:03 C*12:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*05:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*15:01 B*52:01, C*07:02 C*12:02, DRB1*15:01 DRB1*15:02, DQB1*06:01 DQB1*06:02, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*01:01 A*11:01, B*07:02 B*54:01, C*01:02 C*07:02, DRB1*01:01 DRB1*04:05, DQB1*03:03 DQB1*05:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*07:02 X, C*03:03 C*07:02, DRB1*01:01 DRB1*09:01, DQB1*03:03 DQB1*05:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:18 A*33:03, B*44:03 B*46:01, C*01:02 C*14:03, DRB1*04:05 DRB1*08:03, DQB1*04:01 DQB1*06:01, DPB1*02:01 DPB1*02:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*11:01, B*15:01 B*35:01, C*03:03 C*04:01, DRB1*04:06 DRB1*15:01, DQB1*03:02 DQB1*06:02, DPB1*03:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*54:01 B*55:02, C*01:02, DRB1*09:01 DRB1*11:01, DQB1*03:01 DQB1*03:03, DPB1*05:01 DPB1*13:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*39:02 B*40:06, C*07:02 C*08:01, DRB1*09:01 DRB1*12:01, DQB1*03:01 DQB1*03:03, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*26:03 A*31:01, B*35:01 B*51:01, C*03:03 C*14:02, DRB1*04:03 DRB1*15:02, DQB1*03:02 DQB1*06:01, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*02:06 B*07:02 B*40:01, C*03:03 C*07:02, DRB1*01:01 DRB1*08:03, DQB1*05:01 DQB1*06:01, DPB1*03:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*15:01 B*54:01, C*01:02 C*03:03, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*05:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*33:03, B*40:01 B*44:03, C*03:04 C*14:03, DRB1*13:02 DRB1*14:01, DQB1*05:03 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*15:01 B*39:01, C*04:01 C*07:02, DRB1*04:06 DRB1*12:01, DQB1*03:01 DQB1*03:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*35:01 B*44:02, C*05:01 C*08:01, DRB1*04:10 DRB1*12:01, DQB1*03:03 DQB1*04:02, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*31:01, B*40:06 B*44:03, C*03:04 C*14:03, DRB1*09:01 DRB1*13:02, DQB1*03:03 DQB1*06:04, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*33:03, B*15:01 B*44:03, C*03:03 C*14:03, DRB1*08:03 DRB1*14:06, DQB1*03:01 DQB1*06:01, DPB1*03:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*52:01 B*54:01, C*01:02 C*12:02, DRB1*08:03 DRB1*15:01, DQB1*06:01 DQB1*06:02, DPB1*05:01 DPB1*14:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01, B*48:01 B*51:01, C*08:01 C*15:02, DRB1*09:01, DQB1*03:03 , DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*31:01 A*33:03, B*44:03 B*51:01, C*14:02 C*14:03, DRB1*13:02 DRB1*14:03, DQB1*03:01 DQB1*06:04, DPB1*02:01 DPB1*04:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*33:03, B*07:02 B*44:03, C*07:02 C*14:03, DRB1*01:01 DRB1*13:02, DQB1*05:01 DQB1*06:04, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*52:01, C*12:02, DRB1*15:02, DQB1*06:01, DPB1*02:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*44:03 B*52:01, C*12:02 C*14:03, DRB1*04:06 DRB1*13:02, DQB1*03:02 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*02:06, B*35:01 B*39:01, C*03:03 C*07:02, DRB1*09:01 DRB1*14:06, DQB1*03:01 DQB1*03:03, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*31:01, B*40:02 B*44:03, C*03:04 C*14:03, DRB1*09:01 DRB1*13:02, DQB1*03:03 DQB1*06:04, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*46:01 B*54:01, C*01:02 , DRB1*04:05 DRB1*08:03, DQB1*04:01 DQB1*06:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*26:01, B*35:01 B*52:01, C*03:03 C*12:02, DRB1*15:01 DRB1*15:02, DQB1*06:01 DQB1*06:02, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*26:01 A*33:03, B*44:03 B*52:01, C*12:02 C*14:03, DRB1*13:02 DRB1*15:02, DQB1*06:01 DQB1*06:04, DPB1*04:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*51:01 B*52:01, C*12:02 C*14:02, DRB1*08:02 DRB1*15:02, DQB1*04:02 DQB1*06:01, DPB1*04:02 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*07:02 B*46:01, C*03:04 C*07:02, DRB1*01:01 DRB1*08:03, DQB1*05:01 DQB1*06:01, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*15:07 B*52:01, C*01:02 C*12:02, DRB1*04:03 DRB1*15:01, DQB1*03:02 DQB1*06:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*38:0201 B*51:01, C*07:02 C*14:02, DRB1*08:03 DRB1*09:01 , DQB1*03:01 DQB1*03:03, DPB1*05:01 DPB1*14:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*07:02 B*39:01, C*07:02, DRB1*01:01 DRB1*04:05, DQB1*04:01 DQB1*05:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*24:02, B*13:01 B*48:01, C*03:04 C*08:01, DRB1*09:01 DRB1*12:02, DQB1*03:01 DQB1*03:03, DPB1*02:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:02, B*40:01 B*40:06, C*03:04 C*08:01, DRB1*04:05 DRB1*09:01, DQB1*03:03 DQB1*04:01, DPB1*04:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*26:01, B*40:02 B*51:02, C*03:04 C*08:01, DRB1*09:01 , DQB1*03:03, DPB1*02:01 DPB1*03:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*01:01 A*02:01, B*15:01 B*40:06, C*06:02 C*08:01, DRB1*04:05 DRB1*09:01, DQB1*03:03 DQB1*04:01, DPB1*04:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*39:01 B*55:02, C*01:02 C*07:02, DRB1*04:10 DRB1*15:01, DQB1*04:02 DQB1*06:02, DPB1*02:02 DPB1*03:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*26:01, B*40:02 B*52:01, C*03:04 C*12:02, DRB1*08:02 DRB1*15:02, DQB1*03:02 DQB1*06:01, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*26:01, B*40:02 B*54:01, C*01:02 C*03:04, DRB1*01:01 DRB1*09:01, DQB1*03:03 DQB1*05:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*26:01, B*40:01 B*40:02, C*03:04 C*15:02, DRB1*08:03 DRB1*09:01, DQB1*03:03 DQB1*06:01, DPB1*04:01 DPB1*13:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*11:01, B*13:01 B*48:01 C*03:04 C*08:03, DRB1*12:02 DRB1*15:01, DQB1*03:01 , DPB1*02:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*33:03, B*15:11 B*52:01, C*03:03 C*12:02, DRB1*09:01 DRB1*15:02, DQB1*03:03 DQB1*06:01, DPB1*05:01DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*15:11 B*52:01, C*03:03 C*12:02, DRB1*14:54 DRB1*15:02, DQB1*03:01 DQB1*06:01, DPB1*05:01 DPB1*13:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*35:01 B*52:01, C*04:01 C*12:02, DRB1*09:01 DRB1*15:02, DQB1*03:03 DQB1*06:01, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*40:01 B*52:01, C*03:04 C*12:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*02:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*26:01 A*33:03, B*35:01 B*44:03, C*03:03 C*14:03, DRB1*04:01 DRB1*12:01, DQB1*03:01 DQB1*03:03, DPB1*05:01DPB1*14:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*15:01 B*40:06, C*04:01 C*08:01, DRB1*04:06 DRB1*09:01, DQB1*03:02 DQB1*03:03, DPB1*05:01 X
HEV0181 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
An immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0108 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus
HSC0061 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0063 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02 A*31:01, B*52:01 B*59:01, C*01:02 C*12:02, DRB1*04:05 DRB1*15:02, DQB1*04:01 DQB1*06:01, DPB1*04:02 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*15:07 B*15:18, C*03:03 C*07:0401, DRB1*04:01 DRB1*04:03, DQB1*03:01 DQB1*03:02, DPB1*02:01 DPB1*05:01
HSC0139 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
HSC0141 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. This B cell lines derived from Mongoloid Minority Groups in South America.
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*11:01 A*33:03, B*35:01 B*44:03, C*03:03 C*14:03, DRB1*04:05 DRB1*13:02, DQB1*03:02 DQB1*06:04, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*33:03, B*35:01 B*44:03, C*03:03 C*14:03, DRB1*04:05 DRB1*13:02, DQB1*04:01 DQB1*06:04, DPB1*02:01 DPB1*04:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Cell growth is slow. HLA A*24:02 A*26:01, B*15:01 B*51:01, C*03:04 C*04:01, DRB1*04:06 DRB1*14:54, DQB1*03:02 DQB1*05:03, DPB1*02:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:07 A*24:20, B*46:01 B*55:02, C*01:02 C*07:02, DRB1*08:03 , DQB1*06:01, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*02:07. B*40:01 B*46:01, C*01:02 C*15:02, DRB1*08:03 DRB1*14:05, DQB1*05:03 DQB1*06:01, DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*24:02, B*07:02 B*13:01, C*03:03 C*07:02, DRB1*01:01 DRB1*12:02, DQB1*03:01 DQB1*05:01 , DPB1*02:01 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:07 A*24:02, B*46:01 B*52:01, C*01:02 C*12:02, DRB1*08:03 DRB1*15:02, DQB1*06:01, DPB1*02:01 DPB1*09:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*15:11 B*59:01, C*01:02 C*03:03, DRB1*04:05 DRB1*12:01, DQB1*03:01 DQB1*04:01, DPB1*02:02 DPB1*04:02
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:06 A*24:02, B*15:27 B*35:01, C*03:03 C*04:01, DRB1*04:03 DRB1*12:01, DQB1*03:01 DQB1*03:02, DPB1*02:01 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:53N A*26:01, B*39:01 B*54:01, C*01:02 C*07:02, DRB1*14:05 DRB1*15:01, DQB1*05:03 DQB1*06:02, DPB1*04:02 DPB1*05:01
A immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. HLA A*02:01 A*24:02, B*39:01 B*48:01, C*07:02 C*08:01, DRB1*04:05 DRB1*11:01, DQB1*03:01 DQB1*04:01, DPB1*02:01 DPB1*02:02
HEV0083 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0093 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0127 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0266 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0350 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0415 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0431 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0444 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0451 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0487 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus. Breast cancer patient.
HEV0218 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0121 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0477 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0156 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
HEV0101 cell is an immortal human B cell line cell that has the characteristics: Human B lymphocytes transformed by Epstein-Barr Virus.
A immortal human vagina-derived cell line cell that has the characteristics: 47,XX,+X-type chromosome.
Derived from tissue: vagina in animal: human.
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Squamous cell carcinoma. TKG0462(Deposited from Tohoku Univ.).
Derived from tissue: esophagus in animal: human.
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer (highly differentiated squamous cell carcinoma). Not transplantable to nude mouse. TKG0266 (Deposited from Tohoku Univ.).
Originator: Nishihira, Tetsuro (Akaishi, T.)
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Moderately differentiated squamous cell carcinoma. TKG0259(Deposited from Tohoku Univ.).
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Highly differentiated squamous cell carcinoma. TKG0261(Deposited from Tohoku Univ.).
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Moderately differentiated squamous cell carcinoma. TKG0262(Deposited from Tohoku Univ.).
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Moderately differentiated squamous cell carcinoma. TKG0265(Deposited from Tohoku Univ.).
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from poorly differntiated esophageal squamous cell carcinoma. Not transplantable to nude mouse. TKG0256 (Deposited from Tohoku Univ.).
A immortal human esophagus-derived cell line cell that has the characteristics: Highly differentiated squamous carcinoma (esophagus), not transplantable to nude mouse. A culture submitted to the Cell Resource Center for Biomedical Research was found to be contaminated with mycoplasma. Progeny were cured by Treatments with BM Cyclin and MC210. TKG0257 (Deposited from Tohoku Univ.).
A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Highly differentiated squamous cell carcinoma.TKG0255(Deposited from Tohoku Univ.).
Derived from tissue: esophagus, lymph node meta in animal: human.
A immortal human esophagus-derived cell line cell that has the characteristics: Produce hypercalcemia in nude mice. PTH-related protein, IL-1alpha producing.
A immortal human esophagus-derived cell line cell that has the characteristics: Human esophageal squamous cell carcinoma (poorly differentiated) cell line. Not transplantable to nude mouse. TKG0260 (Deposited from Tohoku Univ.).
Derived from tissue: esophagus, pleural effusion in animal: human.
A immortal human gingiva-derived cell line cell that has the characteristics: Human gingival carcinoma cell line. Expressing remarkable EGF receptor. HLA-A 2/24. TKG0485(Deposited from Tohoku Univ.).
Derived from tissue: gingiva in animal: human.
A immortal human muscle cell line cell that has the characteristics: Extraskeltal myxoid chondrosarcoma
Derived from tissue: muscle in animal: human.
A immortal human muscle cell line cell that has the characteristics: Mixed mesodermal tumor consists of adenocarcinoma and rhabdomyosarcoma. Cell growth is slow.
Derived from tissue: muscle, bone marrow meta in animal: human.
A immortal human mouth-derived cell line cell that has the characteristics: Human cell line derived from oral squamous cell carcinoma occurred in 69-yo, male patient. HLA-A 24/. TKG0487 (Deposited from Tohoku Univ.).
A immortal human mouth-derived cell line cell that has the characteristics: Human cell line derived from squamous cell carcinoma at mouth floor. TKG0455(Deposited from Tohoku Univ.).
Derived from tissue: mouth floor in animal: human.
A immortal rat brain-derived cell line cell that has the characteristics: Astroglia cell line. Possible to culture in DMEM medium. See RCB0075.
Derived from tissue: brain in animal: rat.
A immortal rat brain-derived cell line cell that has the characteristics: Astroglia cell line
A immortal rat brain-derived cell line cell that has the characteristics: Rat cell line derived from glial cell tumor induced by N-nitrosomethylurea. TKG0589(Deposited from Tohoku Univ.).
A immortal rat brain-derived cell line cell that has the characteristics: Rat cell line derived from glioma induced by N-nitrosomethylurea. TKG0242 (Deposited from Tohoku Univ.).
RCB2863 cell is an immortal rat brain-derived cell line cell that has the characteristics: Rat neuronal cell line derived from the ventrolateral region of the suprachiasmatic nucleus.
Derived from tissue: brain in animal: rat, Wister (Transgenic rat).
RCB2864 cell is an immortal rat brain-derived cell line cell that has the characteristics: Rat neuronal cell line derived from the ventrolateral region of the suprachiasmatic nucleus.
RCB0489 cell is an immortal human testis-derived cell line cell that has the characteristics: Embryonal carcinoma, testis.
Derived from tissue: testis in animal: human.
RCB0490 cell is an immortal human testis-derived cell line cell that has the characteristics: Embryonal carcinoma, testis.
A immortal human testis-derived cell line cell that has the characteristics: Embryonal carcinoma, testis.
RCB2342 cell is an immortal human testis-derived cell line cell that has the characteristics: Human cell line derived from embryonal carcinoma of testis.
RCB2341 cell is an immortal human testis-derived cell line cell that has the characteristics: Human cell line derived from embryonal carcinoma of testis.
RCB2344 cell is an immortal human testis-derived cell line cell that has the characteristics: Human cell line derived from embryonal carcinoma of testis.
RCB2343 cell is an immortal human testis-derived cell line cell that has the characteristics: Human cell line derived from embryonal carcinoma of testis.
A immortal human intestine-derived cell line cell that has the characteristics: Small-cell gastrointestinal carcinoma. High levels of creatine kinase brain isoenzyme. Cell growth is slow.
Derived from tissue: intestine in animal: human.
A immortal human rectum-derived cell line cell that has the characteristics: Human rectal cancer cell line.
Derived from tissue: rectum in animal: human.
Originator: Ishikawa, Hiroshi & Tabei, Isao
A immortal human rectum-derived cell line cell that has the characteristics: Human cell line derived from rectal cancer. Cell growth is slow.
A immortal human rectum-derived cell line cell that has the characteristics: Rectal carcinoma from a Japanese patient. Cell growth is slow.
A immortal hamster kidney-derived cell line cell that has the characteristics: SV40 transformed hamster cell line. Fibroblast-like cells.
Derived from tissue: kidney in animal: hamster.
A immortal hamster kidney-derived cell line cell that has the characteristics: The parent cell line used for the temperature sensitive cell line series of BN.
Derived from tissue: kidney in animal: hamster, Syrian.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-sensitive mutant of BHK-21. Complemented with human X-linked CCG1 gene.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-sensitive mutant of BHK-21. Complementation group A. Dye rapidly at 39.5 C.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-sensitive mutant of BHK-21 selected after MNNG treatment.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-senstive mutant of BHK-21. Complemented with ubiquitin-activating enzyme E1 cDNA.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-sensitive mutant of BHK-21. Causing premature chromosome condensation.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-sensitive mutant of BHK-21 with mutated DAD1 gene. Causing apoptosis at 39.5 C.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-sensitive mutant of BHK-21 with defect in RNA polymerase III subunit.
A immortal hamster kidney-derived cell line cell that has the characteristics: Temperature-sensitive mutant of BHK-21. Stop growth after 2-day culture at 39.5 C.
A immortal hamster kidney-derived cell line cell that has the characteristics: Thymidine kinase-defective mutant of ts13
A immortal hamster kidney-derived cell line cell that has the characteristics: Culturable in suspension, cf. ECACC, BHK-21C13-3P
A immortal human adrenal gland-derived cell line cell that has the characteristics: N-myc propagated. Neuron specific enolase producing.
Derived from tissue: adrenal in animal: human.
A immortal human adrenal gland-derived cell line cell that has the characteristics: Human cell line derived from neuroblastoma of adrenal gland.TKG0278 (Deposited from Tohoku Univ.).
Derived from tissue: adrenal gland, left in animal: human.
A immortal human adrenal gland-derived cell line cell that has the characteristics: Adrenal neuroblastoma derived from brain metastasis
Derived from tissue: adrenal, brain meta in animal: human.
A immortal human adrenal gland-derived cell line cell that has the characteristics: N-myc gene amplification
Derived from tissue: adrenal, left in animal: human.
A immortal human adrenal gland-derived cell line cell that has the characteristics: Human cell line derived from neuroblastoma formed at adrenal gland. TKG0277(Deposited from Tohoku Univ.).
Derived from tissue: right adrenal gland in animal: human.
Originator: Hayashi, T. (Pediat. Surg., Tohoku Univ.).
A immortal human adrenal gland-derived cell line cell that has the characteristics: Human cell line derived from neuroblastoma. Dibuty-cAMP (1 mM) induces differentiation. TKG0486(Deposited from Tohoku Univ.).
Derived from tissue: sympatho adrenal cell in animal: human.
A immortal mouse blood cell line cell that has the characteristics: Secrete growth factors for hemopoietic stem cells
Derived from tissue: blood in animal: mouse, BALB/c.
A immortal mouse blood cell line cell that has the characteristics: IL-3 dependent pro B cell line. Information
Derived from tissue: blood in animal: mouse, C3H.
A immortal mouse blood cell line cell that has the characteristics: Spontaneouly differentiated cell line derived from M1. Non-tumorigenic.
Derived from tissue: blood in animal: mouse, SL.
A immortal rhesus macaque kidney-derived cell line cell that has the characteristics: Highly susceptible to Simian rotavirus SA11. Backup of ECA85102918.
Derived from tissue: fetal, kidney in animal: monkey, rhesus.
A immortal mouse monocyte cell line cell that has the characteristics: Buck-up culture of ECA85062803. Mouse leukemic monocyte. Abelson leukemia virus induced.
Derived from tissue: leukemic monocyte in animal: mouse, BALB/c.
A immortal rat kidney-derived cell line cell that has the characteristics: Contact-inhibited semi-normal, original of NRK49F
Derived from tissue: kidney in animal: rat.
A immortal rat kidney-derived cell line cell that has the characteristics: Contact-inhibited semi-normal cell line
RCB1799 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat (Wistar) cell line derived from renal (kidney) tumor.
Derived from tissue: kidney in animal: rat, Wistar.
A immortal rat kidney-derived cell line cell that has the characteristics: Rat renal tumor derived cell line.
RCB1798 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat (Wistar) cell line derived from renal (kidney) tumor.
RCB1800 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat cells derived from kidney carcinoma. After passage 2. Wister rat.
RCB1801 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat cell line derived from kidney carcinoma. After passage 100. Wister rat.
RCB1802 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat cells derived from kidney carcinoma. After passage 2. Wister rat.
A immortal rat kidney-derived cell line cell that has the characteristics: Rat cell line derived from kidney carcinoma. After passage 80. Wister rat.
RCB1804 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat cells derived from kidney carcinoma. After passage 2. Wister rat.
RCB1805 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat cell line derived from kidney carcinoma. After passage 100. Wister rat.
RCB1806 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat cells derived from kidney carcinoma. After passage 2. Wister rat.
RCB1807 cell is an immortal rat kidney-derived cell line cell that has the characteristics: Rat cell line derived from kidney carcinoma. After passage 100. Wister rat.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Krukenberg tumor cell line
Derived from tissue: ovary in animal: human.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Clear cell adenocarcinoma. Said CA125, CA72-4 producing.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Ovary serous adenocarcinoma. Said CA125, CA15-3 producing.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary mucinous adenocarcinoma cell line.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Serous cystadenocarcinoma. CA125 producing. Cell growth is slow.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary serous cyst adenocarcinoma cell line. Cell growth is slow.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary mucinous tubular adenocarcinoma cell line. Cell growth is slow.
RCB1688 cell is an immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary clear cell carcinoma cell line. Cell growth is slow.
RCB1723 cell is an immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary clear cell carcinoma cell line. Cell growth is slow.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human cell line derived from ovary cancer. Clear cell carcinoma. Cell growth is slow.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Mucinous cystadenocarcinoma. Said CA125,CA19-9 (+). Cell growth is slow.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human cell line derived from ovarian squamous cell cancer.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Japanese ovarian serous adenocarcinoma. Said CA125 producing. Cell growth is slow.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human cell line derived from adenocarcinoma of ovary. TKG0602(Deposited from Tohoku Univ.).
Derived from tissue: ovary, ascites meta in animal: human.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human cell line derived from ovarial cancer, subclone of RCB2535. TKG0323 (Deposited from Tohoku Univ.).
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human cell line derived from ovarian endometrioid carcinoma, subclone of RCB1903. TKG0357 (Deposited from Tohoku Univ.).
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Granulosa cell tumor. Possible to produce progesterone after HCG addition. Cell growth is slow.
Derived from tissue: ovary, peritoneum in animal: human.
Originator: Nishi, Yoshihiro & Nawata, Hajime
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Lymphnode-metastatic ovarian tumor. So called HM-1 cells.
Derived from tissue: ovary in animal: mouse, C57BL x C3H.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Worm cell line established by Grace. Culturable in MGM-450-10%FBS.
Derived from tissue: ovary in animal: silkworm.
A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Useful for recombinant BmNPV expression
RCB2125 cell is an immortal human ovary-derived fibroblast cell line cell that has the characteristics: Silkworm (Bombyx mori) cell line derived from ovary. Useful for the identification and analysis of homologous recombination-related genes in the silkworm.
RCB2126 cell is an immortal human ovary-derived fibroblast cell line cell that has the characteristics: Silkworm (Bombyx mori) cell line derived from ovary. Useful for the identification and analysis of homologous recombination-related genes in the silkworm.
A immortal chicken B cell line cell that has the characteristics: SHP1 deficient DT40 cells
Derived from tissue: B cell in animal: avian.
A immortal chicken B cell line cell that has the characteristics: Ku70 gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: Rad51B gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: Rad51C gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: Rad51D gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: XRCC2 gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: Rad52 gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: Rad54 and Rad54B gene double-deleted DT40 (chicken B cells).
A immortal chicken B cell line cell that has the characteristics: Rad54 gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: Ku70 and Rad54B gene double-deleted DT40 (chicken B cells).
A immortal chicken B cell line cell that has the characteristics: XRCC3 gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: BLNK and Grb2 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: SHIP deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Grb2 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: SHP1 and SHP2 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: BLNK and Syk deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Btk deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: PLC-γ2 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Syk deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Lyn deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Grap deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: IP3R type1 and IP3R type3 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: IP3R type2and IP3R type3 deficient DT40
A immortal chicken B cell line cell that has the characteristics: Grb2and Grap deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: TRP1 deficient DT40
A immortal chicken B cell line cell that has the characteristics: SHP2 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Shc deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: BLNK deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Cbl deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: BCAP deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Vav3 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: PI3Kp110α deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Rad54 gene deleted DT40 (chicken B cells). Inducible expression of human Rad54 is possible.
A immortal chicken B cell line cell that has the characteristics: ATM gene deleted DT40 (chicken B cells).
A immortal chicken B cell line cell that has the characteristics: ATM and Rad54 gene double-deleted DT40 (chicken B cells). Inducible expression of human Rad54 is possible.
A immortal chicken B cell line cell that has the characteristics: Endogenous Ubc9 deficient DT40 cells but expressing Ubc9 exogenously
A immortal chicken B cell line cell that has the characteristics: Ras GRP1 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Lyn and Sky deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: DNA PK gene deleted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: Rad51 gene deleted and human Rad51 gene inserted DT40 (chicken B cell line).
A immortal chicken B cell line cell that has the characteristics: ATM and Ku70 gene double-deleted DT40 (chicken B cells).
A immortal chicken B cell line cell that has the characteristics: IP3R type1 and IP3R type2 deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Mre11 gene deleted DT40 (chicken B cell line), subclone of RCB1630.
A immortal chicken B cell line cell that has the characteristics: Mre11 gene deleted DT40 (chicken B cell line), subclone of RCB1629.
A immortal chicken B cell line cell that has the characteristics: IP3R(type1,type2,type3) deficient DT40 cells
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 (chicken B cell line), lacking Nbs1 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking DinB expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking Rad18 expression.
A immortal chicken B cell line cell that has the characteristics: Rad54 and Ku70 gene double-deleted DT40 (chicken B cells).
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking Rev3 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both of Rad52 and XRCC3 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both of RasGRP1 and RasGRP3 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking RasGRP3 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking Sos1 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking Sos2 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both Sos1 and Sos2 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both of DNAPK and Ku70 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking XRCC3 only in one allele.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking BLM (Bloom syndrome gene) expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both of Rad18 and XPA expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both of Rad18 and DinB expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both of WRN (Werner syndrome gene) and BLM (Bloom syndrome gene) expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking both of DinB and XPA expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking WRN (Werner syndrome gene) expression.
A immortal chicken B cell line cell that has the characteristics: Chicken B cell line transformed by avian leukosis virus. c-myc and IgM expressing.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking CARMA1 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking PKC-β expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking TAK1 expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking ligase IV expression.
A immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, lacking STIM1 expression.
A immortal chicken B cell line cell that has the characteristics: Mre11 and Ku70 gene double-deleted DT40 (chicken B cells).
RCB1768 cell is an immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, which lacks XRCC3 inducibly by tamoxifen.
RCB1769 cell is an immortal chicken B cell line cell that has the characteristics: Subline of DT40 cell line, which lacks XRCC3 inducibly by tamoxifen.
A immortal chicken B cell line cell that has the characteristics: IL-5 dependent early B-cell line. Also grows on IL-3. The population contain non-IL-5-dependent cell
Derived from tissue: B cell in animal: mouse.
A immortal human prostate gland-derived cell line cell that has the characteristics: Human cell line derived from malignant peripheral nerve sheath tumor.
Derived from tissue: prostate in animal: human.
A immortal human prostate gland-derived cell line cell that has the characteristics: Human cell line derived from bone metastasis of prostatic cancer. TKG0600(Deposited from Tohoku Univ.).
Derived from tissue: prostate, bone meta in animal: human.
A immortal human prostate gland-derived cell line cell that has the characteristics: Human cell line derived from brain metastasis of prostate carcinoma. TKG0604(Deposited from Tohoku Univ.).
Derived from tissue: prostate, brain meta in animal: human.
A immortal human prostate gland-derived cell line cell that has the characteristics: Human cell line derived from prostate adenocarcinoma. Derived from lymph node metastasis. TKG0603(Deposited from Tohoku Univ.).
Derived from tissue: prostate, lymph node meta in animal: human.
A immortal human duodenum-derived cell line cell that has the characteristics: Papillotubular adenocarcinoma of the Vater's papilla. Cell growth is slow.
Derived from tissue: duodenum in animal: human.
RCB0478 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: N-myc gene amplification.
Derived from tissue: bone marrow in animal: human.
RIKEN: COSMIC ID:910929; Riken RCB0478,RCB0478
RCB0479 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: N-myc gene amplification.
A immortal human bone marrow-derived cell line cell that has the characteristics: N-myc gene amplicon analysis
RCB0483 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: N-myc gene amplification.
A immortal human bone marrow-derived cell line cell that has the characteristics: Human acute myeloid leukemia derived cell.
A immortal human bone marrow-derived cell line cell that has the characteristics: Japanese AML. Said i(12p)(p11) and unbalanced t(5;12). Need confirmation before use.
A immortal human bone marrow-derived cell line cell that has the characteristics: Subline of F-36P. Erythropoietin-dependent
A immortal human bone marrow-derived cell line cell that has the characteristics: Human cell line derived from bone marrow stromal cells. Useful to propagate hematopoietic stem cells.
A immortal human bone marrow-derived cell line cell that has the characteristics: Human T-cell line derived from acute lynphblastic leukemia. TKG0251 (Deposited from Tohoku Univ.).
A immortal human bone marrow-derived cell line cell that has the characteristics: Human cell line derived from megakaryoblastic leukemia. TKG0458(Deposited from Tohoku Univ.).
A immortal human bone marrow-derived cell line cell that has the characteristics: GM-CSF- or IL-3-dependent cell line. Differentiate to erythoid cells with erythropoietin.
RCB2153 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by HPV E6, E7, and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
A immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by HPV E6, E7, and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
A immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by bmi-1, HPV E6, and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
RCB2157 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by bmi-1, HPV E6, and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
RCB2158 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by HPV E7 and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
RCB2159 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by HPV E6, E7, and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
RCB2161 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by HPV E7 and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
RCB2160 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by HPV E6, E7, and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
RCB2162 cell is an immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by bmi-1, HPV E6, and hTERT. RCB2152- RCB2163 are derived from the same bone marrow.
A immortal human bone marrow-derived cell line cell that has the characteristics: Human mesenchymal cell line derived from bone marrow. Immortalized by HPV E6 and E7. RCB2152- RCB2163 are derived from the same bone marrow.
A immortal human bone marrow-derived cell line cell that has the characteristics: Human acute myeloid leukemia. The variant subline (RCB1928 KG-1a) CD3-,CD13+,CD14-,CD15+,CD19-,CD33+
A immortal human bone marrow-derived cell line cell that has the characteristics: Human cell line derived from acute myelogenous leukemia. The variant subline of KG-1(RCB1166) cell line. TKG0402(Deposited from Tohoku Univ.).
A immortal human bone marrow-derived cell line cell that has the characteristics: p53 deficient mouse bone marrow derived cell. Useful for study of p53 suppressor oncogene. Cell growth is slow.
Derived from tissue: bone marrow in animal: mouse, 129/sv-(p53-/-).
A immortal human eye-derived cell line cell that has the characteristics: Human cell line derived from retinoblastoma. TKG0601(Deposited from Tohoku Univ.).
Derived from tissue: eye in animal: human.
A immortal human eye-derived cell line cell that has the characteristics: Caucasian retinoblastoma. May have reverse transcriptase. Back up culture of ECA2583.
A immortal human eye-derived cell line cell that has the characteristics: alpha, beta-crystaline expressing human lense epithelial cell line. plasmid DNA: pRSV-B-T Ag.
Derived from tissue: eye, lens in animal: human.
A immortal human tongue-derived cell line cell that has the characteristics: Highly sensitive to bleomycin
Derived from tissue: tongue in animal: human.
A immortal human tongue-derived cell line cell that has the characteristics: Human tongue squamous cell carcinoma derived cell line. TKG0489 (Deposited from Tohoku Univ.).
A immortal human tongue-derived cell line cell that has the characteristics: Human cell line derived from tongue cancer. Squamous cell carcinoma. TKG0470(Deposited from Tohoku Univ.).
A immortal human tongue-derived cell line cell that has the characteristics: Human tongue squamous cell carcinoma cell line. HLA-A 2/24. TKG0484(Deposited from Tohoku Univ.).
A immortal mouse B cell line cell that has the characteristics: Mouse cell line derived from B cell lymphoma.
Derived from tissue: B cell lymphoma in animal: mouse.
A immortal mouse B cell line cell that has the characteristics: Mouse cell line derived from B cell leukemia. TKG0435 (Deposited from Tohoku Univ.).
Derived from tissue: B cell leukemia in animal: mouse, BALB/C.
A immortal Chinese hamster cell line cell that has the characteristics: H2O2 resistant Chinese Hamster V79 cells
Derived from tissue: lung in animal: hamster, Chinese.
A immortal Chinese hamster cell line cell that has the characteristics: Chinese hamster lung fibroblast
A immortal Chinese hamster cell line cell that has the characteristics: Pseudodiploid, two marker chromosomes
A immortal Chinese hamster cell line cell that has the characteristics: Widely used in chromosome aberration test
A immortal Chinese hamster cell line cell that has the characteristics: A subline of the V79 cell line following cloning. Widely used for radiation biology, mutagenesis and mammalian cell genetics.
A immortal Chinese hamster cell line cell that has the characteristics: A subline of the V79 cell line. Widely used for radiation biology, mutagenesis and mammalian cell genetics.
A immortal Chinese hamster cell line cell that has the characteristics: X-ray-sensitive mutant derived from the V79 cell line. XRCC8 gene deficient.
A immortal Chinese hamster cell line cell that has the characteristics: A subline of the V79 cell line. X-ray-sensitive mutant. XRCC8 gene deficient.
A immortal Chinese hamster cell line cell that has the characteristics: A subline of the V79 cell line. X-ray-sensitive mutant. XRCC5(ku80) gene deficient.
A immortal Chinese hamster cell line cell that has the characteristics: A subline of the V79B cell line. X-ray-sensitive mutant. XRCC5(ku80) gene deficient.
A immortal Chinese hamster cell line cell that has the characteristics: Chinese hamster cell line. Epithelial-like adherent cells.
Derived from tissue: unknown in animal: hamster, Chinese.
A immortal Chinese hamster cell line cell that has the characteristics: Smooth muscle cell sarcoma from Chinese hamster.
Derived from tissue: uterus in animal: hamster, Chinese.
A immortal rat colon-derived cell line cell that has the characteristics: Metastasis to liver
Derived from tissue: colon in animal: rat, F344.
RCB0511 cell is an immortal rat colon-derived cell line cell that has the characteristics: Metastasis to liver, lung.
RCB0510 cell is an immortal rat colon-derived cell line cell that has the characteristics: Metastasis to liver, lung.
A immortal rat embryo-derived cell line cell that has the characteristics: Suitable as feeders for hybridoma cloning
Derived from tissue: embryo in animal: rat, Wistar.
A immortal Syrian golden hamster cell line cell that has the characteristics: Mutin producing, BHP-induced pancreatic tumor
Derived from tissue: pancreas in animal: hamster, Syrian.
RCB1175 cell is an immortal gold fish blood cell line cell that has the characteristics: Tumor cells derived from Gold Fish red pigment cells.
Derived from tissue: body in animal: gold fish.
RCB1176 cell is an immortal gold fish blood cell line cell that has the characteristics: Tumor cells derived from Gold Fish red pigment cells.
A immortal gold fish cell line cell that has the characteristics: Gold fish erythrophoroma with 4n chromosomal mode
Derived from tissue: erythrophoroma in animal: gold fish.
A immortal gold fish cell line cell that has the characteristics: Tumor cells derived from Gold Fish red pigment cells.
Derived from tissue: flank in animal: gold fish.
A immortal gold fish cell line cell that has the characteristics: Pinna fibroblast
Derived from tissue: pinna in animal: gold fish.
A immortal gold fish cell line cell that has the characteristics: Scale fibroblast
Derived from tissue: scale in animal: gold fish.
A immortal gold fish cell line cell that has the characteristics: Scale fibroblast. Possible to culture in DMEM medium. See RCB0082.
A immortal mouse rectum-derived cell line cell that has the characteristics: Mouse cell line derived from rectal cancer. BALB/c strain.TKG0518(Deposited from Tohoku Univ.).
Derived from tissue: rectum in animal: mouse, BALB/c.
RCB2300 cell is an immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary gland carcinoma which is induced by DMBA in the transgenic rat expressing human prototype c-Ha-ras gene.
Derived from tissue: mammary gland in animal: rat, c-Ha-ras transgenic.
RCB2299 cell is an immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary gland carcinoma which is induced by DMBA in the transgenic rat expressing human prototype c-Ha-ras gene.
RCB2301 cell is an immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary gland carcinoma which is induced by DMBA in the transgenic rat expressing human prototype c-Ha-ras gene.
RCB2302 cell is an immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary gland carcinoma which is induced by DMBA in the transgenic rat expressing human prototype c-Ha-ras gene.
RCB2303 cell is an immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary gland carcinoma which is induced by DMBA in the transgenic rat expressing human prototype c-Ha-ras gene.
RCB2304 cell is an immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary gland carcinoma which is induced by DMBA in the transgenic rat expressing human prototype c-Ha-ras gene.
A immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary carcinoma. TKG0132(Deposited from Tohoku Univ.).
Derived from tissue: mammary gland in animal: rat, SD.
A immortal rat mammary gland-derived cell line cell that has the characteristics: Rat cell line derived from mammary carcinoma. TKG0565(Deposited from Tohoku Univ.).
Derived from tissue: mammary gland in animal: rat, Wistar.
A immortal mouse endothelial cell line cell that has the characteristics: Vascular endothelial cells derived from pituitary gland of temperature-sensitive T antigen transgenic mouse.
RCB0410 cell is an immortal human adrenal cortex-derived cell line cell that has the characteristics: Fibroblasts from multiple endocrine neoplasia.
Derived from tissue: adrenal cortex in animal: human.
RCB0421 cell is an immortal human adrenal cortex-derived cell line cell that has the characteristics: Fibroblasts from multiple endocrine neoplasia.
A immortal human adrenal cortex-derived cell line cell that has the characteristics: Buck-up culture of ECA85051002. Mouse steroid hormone secreting adrenal cortex cell line.
Derived from tissue: adrenal cortex in animal: mouse.
A immortal human mammary gland-derived cell line cell that has the characteristics: Same as OCUB-1, OCUB-F. Chromosome = pseudotetraploid.
Derived from tissue: mammary gland, pleural fluid in animal: human.
A immortal human mammary gland-derived cell line cell that has the characteristics: Same as OCUB-1, OCUB-M. Chromosome = pseudodiploid
A immortal mink cell line cell that has the characteristics: Mink (RCB1833) cells transformed by Moloney murine sarcoma virus.
Derived from tissue: lung in animal: mink.
A immortal mink cell line cell that has the characteristics: Lung epithelial cell line derived from mink. Useful for focus forming assays for murine leukemia virus.
A immortal medaka cell line cell that has the characteristics: Medaka cell line derived from HdrR strain.
Derived from tissue: embryo in animal: medaka.
RCB2944 cell is an immortal medaka cell line cell that has the characteristics: Medaka cell line derived from HB32 strain.
RCB2946 cell is an immortal medaka cell line cell that has the characteristics: Medaka cell line derived from HB32 strain.
A immortal medaka cell line cell that has the characteristics: Medaka cell line derived from HNI strain.
Derived from tissue: caudal fin in animal: medaka.
A immortal medaka cell line cell that has the characteristics: H04C medaka hepatoma pretreated with MAM-acetate
Derived from tissue: liver in animal: medaka.
A immortal medaka cell line cell that has the characteristics: Medaka cell line derived from hepatoma cells.
A immortal medaka cell line cell that has the characteristics: Fish (medaka) fin fibroblast. Cell growth is slow.
Derived from tissue: fin in animal: medaka.
A immortal medaka cell line cell that has the characteristics: HB32C medaka treated with MNNG. From peritoneum. Amelanotic. Cell growth is slow.
Derived from tissue: melanoma in animal: medaka.
RCB2319 cell is an immortal cell line cell that has the characteristics: Fibroblast-like cells derived from African Savannah Elephant. Primary cultured cells. Elephant cell lines require import and export permits according to the Convention on International Trade in Endangered Species (CITES).
Derived from tissue: gums in animal: African Savannah Elephant.
A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
CL and GO definitions of cell differ based on inclusive or exclusive of cell wall, etc.
We struggled with this definition. We are worried about circularity. We also considered requiring the capability of metabolism.
The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged.
Primary cultured cells are cells directly extracted from living organisms and then cultivated in a laboratory under controlled environmental conditions. After extraction, these cells can grow and reproduce when provided with the appropriate nutrients. The establishment of primary cell cultures involves processes like tissue dissection, enzymatic or mechanical disaggregation, suspension, and plating. These cells closely mimic the biochemical and physiological conditions of cells in vivo, providing a more realistic model of biological function compared to other cell culture systems. Retaining most physiological and morphological characteristics of the original tissue, primary cultured cells are a powerful tool for modeling diseases, drug responses, and basic biological functions such as synthesis and metabolism. They find extensive use in research fields such as cellular biology, genetics, pharmacology, oncology, and toxicology. Despite their genetic stability, primary cultured cells have a finite lifespan and are not immortal. They undergo senescence after a specific number of population doublings, influenced by genetic, environmental, and epigenetic factors. Given their limited lifespan, primary cells are crucial for experimental replicability, and their cultivation demands meticulous care to prevent changes that might alter cell identity or function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Covers cells actively being cultured or stored in a quiescent state for future use.
A cell in vitro that is or has been maintained or propagated as part of a cell culture.
Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture.
A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids.
Any neuron that develops from some migratory neural crest cell.
A cell that will develop into a neuron often after a migration phase.
A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
Stem cells are a unique type of cell that has the remarkable ability to divide and develop into many different types of cells in the body. These cells are undifferentiated, meaning they haven't yet developed into a specific cell type, and they can renew themselves through cell division. As a result, stem cells have the potential to replace damaged or diseased cells in the body, making them a valuable tool in medicine and research. There are two main types of stem cells: embryonic stem cells and adult stem cells. Embryonic stem cells are derived from embryos and can develop into any type of cell in the body. Adult stem cells, on the other hand, are found in various tissues and organs throughout the body and can only develop into certain types of cells. Stem cells have numerous potential applications in medicine, including the treatment of various diseases and the repair of damaged tissues. For example, they could be used to replace damaged heart tissue after a heart attack or to repair spinal cord injuries. Stem cells also have potential uses in drug development and disease research, as they can be used to model diseases and test potential therapies in vitro. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues.
Epithelial fate stem cells, also known as epithelial stem cells, possess remarkable abilities for self-renewal and the generation of diverse cell types constituting epithelial tissues. The epithelium, derived from these cells, acts as the body's frontline defense against external threats and facilitates the exchange of nutrients, gases, and waste materials within the internal environment. Epithelial fate stem cells contribute to tissue development, homeostasis, and repair, maintaining the structural and functional stability of epithelial tissues throughout the human body, including the skin, organs, and glands. Through a delicate balance of quiescence, proliferation, and differentiation, these cells ensure the continuous turnover of epithelial cells. Furthermore, these cells serve a critical role in cellular differentiation, where initially unspecialized stem cells mature into specialized entities that perpetuate the functionality of epithelial tissues. This process is intricately regulated by a network of gene expression patterns and external signaling cues to guarantee a coordinated and balanced cellular turnover. Hence, epithelial fate stem cells, with their unique attributes of self-renewal and differentiation, are central to the physiological and reparative functions performed by epithelial tissues in the human body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types.
A stem cell that can give rise to multiple lineages of cells.
A progenitor cell committed to the megakaryocyte and erythroid lineages.
The megakaryocyte-erythroid progenitor (MEP) cell belongs to the multipotent hematopoietic progenitor cells, which can give rise to multiple different cell types. They are found in the bone marrow, the primary organ where new blood cells are generated. MEPs are specially programmed to develop into two distinct blood cell lineages, namely megakaryocytes, which go on to produce platelets for blood clotting, and the erythroid lineage which consists of red blood cells responsible for oxygen transport in the body. The MEP cells are the result of a decision-making process within the hematopoietic stem cell population. Hematopoietic stem cell can differentiate into multiple types of progenitor cells, including myeloid progenitor cells. A further subdivision within this myeloid lineage generates the MEP cells. Therefore, these megakaryocyte-erythroid progenitors represent a key juncture between hematopoietic stem cells and mature blood cell types in the myeloid lineage. Megakaryocyte-erythroid progenitor cells play a crucial role in the homeostasis of some of the most crucial constituents of blood. The megakaryocytes produced from these bipotent progenitor cells contribute to hemostasis by producing platelets - small anucleated fragments that are pivotal for blood clotting and preventing bleeding. Similarly, the erythroid lineage from MEP cells gives rise to erythrocytes, which harbor hemoglobin, the molecule that transports oxygen from lungs to every nook and corner of the body. An imbalance or malfunction in MEP function thus can significantly impact human health, leading to diseases like thrombocytopenia or anemia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
colony forming unit erythroid megakaryocyte
MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.
Osteoblasts are a type of bone cell primarily responsible for bone formation. Osteoblasts are derived from mesenchymal stem cells, which differentiate into osteoblasts under the influence of various growth factors, including bone morphogenetic proteins (BMPs). These multipotent cells play a critical role in the bone formation process known as ossification. The primary function of osteoblasts is to synthesize and deposit bone matrix, a mixture of organic substances and inorganic materials. This included producing a mix of collagen and non-collagenous proteins, which they secrete to create the organic portion of the extracellular bone matrix. The osteoblasts also initiate the mineralization process by depositing calcium and phosphate ions onto this organic matrix, generating a material that is incredibly strong and resilient, which we recognize as bone. Furthermore, osteoblasts are intricately involved in bone remodeling. They communicate with other specialized bone cells, like osteoclasts (involved in bone resorption) and osteocytes (derived from osteoblasts and important for bone maintenance), helping to maintain skeletal health and homeostasis. Dysregulation of osteoblast function can lead to various bone diseases, illustrating the importance of these cells in skeletal health and development. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
non-encoded relationships from VSAO - capable_of_producing VSAO:0000020
A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
An epithelial cell that is part of a duct.
Duct epithelial cells are distinctly specialized cells that predominantly form the lining of glandular ducts. These cells play a crucial role in the secretion, absorption, and transport of fluids depending on the organ they inhabit. They are typically organized in a tubular structure, forming collectively the conduit for the transport of substances. These cells exhibit tight junctions, enabling the careful regulation of the passage of substances and ensuring that no unwanted particles seep through. They are predominantly characterized by their polarized nature, having distinct apical and basolateral surfaces that support its functions of secretion and absorption. The apical surface, exposed to the duct lumen, is specialized for secretion and interaction with the luminal environment, while the basolateral surface is oriented towards the underlying tissue, facilitating interactions with neighboring cells and the extracellular matrix. The ducts serve as the bridge between the gland and the site of secretion, allowing the substances produced by the gland to exit into the body. Thus, duct epithelial cells have a sweeping role in various physiological functions, ranging from defense against pathogens in the respiratory and digestive tracts, to secretion of digestive enzymes, to milk production in mammary glands. As a result of their specialized function, any impairment in the function of duct epithelial cells to function properly often leads to certain diseases or disorders. Studies have identified potential correlation between malfunctioning duct epithelial cells and conditions such as cystic fibrosis, chronic obstructive pulmonary disease, and certain cancers, particularly breast and pancreatic. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
An epithelial cell that has a flattened morphology.
A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement.
Mesothelial cells are crucial components of the mesothelium, a protective layer that lines the body's internal cavities, including pleural cavity (around the lungs), the pericardial cavity (around the heart), and the peritoneal cavity (within the abdomen). Derived from the embryonic mesoderm layer, these cells exhibit a squamous-like epithelial morphology, usually appearing as a single layer of flat, pavement-like cells in their healthy state. Mesothelial cells play a vital role in various physiological processes, such as intraperitoneal immunity, fibrinolysis, tissue repair, and tumor suppression. Their primary function is to provide a slippery, non-adhesive and protective surface to reduce friction and eases the movements of the organs within the pleural, pericardial, and peritoneal cavities, and they participate in the transport and movement of fluid and various molecules across the so-called serosal cavities. These cells have adaptive capabilities that facilitate their role in many pathological processes. In response to injury or inflammation, mesothelial cells can undergo morphological and functional changes, such as mesothelial-mesenchymal transitions, aiding in wound healing and tissue repair. Dysfunctions of mesothelial cells, however, can lead to serious health conditions, including adhesions, fibrosis, and malignancies such as peritoneal and pleural mesotheliomas. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport.
An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane.
Stratified epithelial cells form layers of cells stacked on top of one another, and they primarily function as a protective barrier. Their appearance can be cuboidal, columnar or squamous, and they offer a layer of defense against foreign bodies, harmful substances, pathogens, and prevent water loss and electrolyte imbalance within the body. Depending on the organ and its specific function, the topmost layer of these cells may be specialized as keratinized or non-keratinized. The skin, being constantly exposed to external physical stress, is composed of keratinized stratified epithelial cells that prevent desiccation and provide additional protection. In contrast, non-keratinized stratified epithelial cells line internally exposed surfaces like the oral cavity, esophagus, and vagina, where lubrication is required. In addition to protection, stratified epithelial cells also contribute to tissue repair processes, referred to as epithelialization. Basal epithelial cells are capable of rapid division and migration to heal wounds and maintain the protective barrier function of the tissues they line. Despite having a limited lifespan, these cells ensure a constant replacement process, maintaining their population and the integrity of epithelial layers. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A cell found predominately in the blood.
A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
Mast cells, also known as mastocytes, are a type of innate immune cell. They originate from multipotent hematopoietic progenitor cells within the bone marrow, after which they migrate into nearly all tissues throughout the body. In these tissues, mast cells undergo complete maturation, with the exception of the blood. They are most densely located in the interfaces between the internal and external environments, such as the skin, respiratory system, and gastrointestinal mucosa. Mast cells are crucial players against pathogens and serve as first-line defense components. They contain numerous granules rich in histamine and heparin and are known primarily for their role in allergy and anaphylaxis. Upon encountering an allergen, pathogen, or even certain drugs and toxins, mast cells release these mediators via degranulation. Histamine induces vasodilation and vascular permeability, allowing for immune cells to rapidly reach the site of infection, while heparin prevents clotting in these areas to facilitate immune cell recruitment. Mast cells may also selectively secrete mediators without degranulation. These cells also play other functions beyond immune defense. They are involved in wound healing processes and maintenance of tissue integrity, angiogenesis, and even regulation of physiological functions in the gut. Consequently, because of their wide-ranging impacts, abnormalities in mast cell function can result in various disorders, including those related to allergies, inflammation, and autoimmune conditions. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body.
The bipolar neuron is a type of nerve cell primarily found mainly in the sensory systems of the human body. These specialized cells possess two distinctive extensions or processes - one axon and one dendrite, emerging from the cell body on opposite ends, which gives them their bipolar appearance. These two extensions serve as conduits for electrical signals, with the dendrite primarily playing the role of receiving signals, and the axon transmitting them further. Functionally, bipolar neurons are crucial in facilitating the transmission of special senses, particularly in the senses of sight, smell, hearing, and balance. For example, the bipolar neurons in the retina convey information about light intensity, color, and movement from the photoreceptors to the ganglion cells, forming part of the pathway for visual input to travel towards the brain. Similarly, in the olfactory system, the olfactory cells are bipolar neurons characterized by a peripheral process, called the olfactory rod, which projects fine cilia. These cilia are the sites of olfactory receptors which play a critical role in recognizing thousands of odorant molecules and transmit information about smell from the nose to the brain. Bipolar neurons are also involved in hearing. The vestibular ganglion contains thousands of bipolar neurons that receive sensory signals from hair cells in the inner ear. The nerve signals pass through the bipolar neurons and leave along the vestibular nerve. The morphology of bipolar neurons with their single dendrite and axon also subtly boosts their efficiency, maintaining a streamlined path for signal conduction. Their distinctive structuring allows for faster and more targeted relay of sensory information from the body's peripheries to the central nervous system. Loss or damage of these neurons would directly impact sensory reception and could lead to disorders related to vision, hearing, smell, or balance, underlining the significance of this cell type in the body's sensory capacity. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A vertebrate phagocyte with a single nucleus.
Mononuclear phagocytes are immune cells that form a critical part of the body's innate immune system, the body's first line of defense against infections. Mononuclear phagocytes are characterized by the presence of a single, large nucleus. The ‘Mononuclear Phagocyte System’ nomenclature was introduced to distinguish mononuclear monocytes and macrophages from other cells with multiple nuclei. However, the cells within the mononuclear phagocyte system represent a highly heterogeneous group, all of which are able to perform highly efficient phagocytosis - engulfing and digesting microbes and cellular debris to fight infections and to maintain normal tissue homeostasis. In addition to phagocytosis, mononuclear phagocytes also secrete chemical compounds to recruit other immune cells to a site of infection. These cells produce different types of signaling molecules, including cytokines, chemokines, and reactive oxygen species, triggering a cascade of responses to ensure rapid and efficient containment and neutralization of invading pathogens. These cells are also involved in antigen presentation, a process essential for stimulating an adaptive immune response. They can process and present antigens to T cells, thereby linking the innate and adaptive immune responses. Mononuclear phagocytes play key roles in tissue repair and remodeling. After infection or injury, these cells help in the clearance of dead cells and debris, a crucial step in the initiation of tissue remodeling and the resolution of inflammation. Overall, mononuclear phagocytes are versatile cells that have tailored their functions to meet the unique challenges of different tissues within the body. They are pivotal in homeostasis, immunity, and inflammation, making them important aspects in a range of human diseases including infection, autoimmunity, and cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.
From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
A neuron that has dendritic processes radiating from the cell body forming a star-like shape.
Stellate neurons are a specialized type of interneurons found predominantly in the cerebral cortex and the cerebellum, two major components of the brain's central nervous system. These neurons are named for their distinct star-like shape, characterized by short dendrites that radiate from the cell body in multiple directions. They are a key component of the mammalian neural circuit due to their unique morphology and crucial functions in neural communication. Stellate neurons play a pivotal role in the processing and transmission of information within the brain. In the cerebellum, these neurons are predominantly inhibitory and release the neurotransmitter gamma-aminobutyric acid (GABA), effectively regulating the excitability of other neurons within the network and thus fine-tuning the neuron-to-neuron communication. Their extensive dendritic network allows for connections with multiple neurons allowing for the integration of synaptic inputs from various sources in the brain. This widespread connectivity places stellate neurons at the heart of information processing in the central nervous system. In addition to their important inhibitory role in regulating and processing information, the role of stellate neurons in the cerebellum differs slightly from their cortical counterparts. The cortical spiny stellate neurons are excitatory and release the neurotransmitter glutamate. They are involved in motor control and responsible for coordinating precise, voluntary movements and maintaining posture and balance. Any dysfunction in these cerebellar neurons can lead to movement disorders, highlighting their significance in our daily activities. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
Glial cells, also known as neuroglia or simply glia, are non-neuronal cells in the central and peripheral nervous systems that provide support and protection for neurons. They constitute approximately half of the total cells in the human brain and more than half in other parts of the nervous system. Glial cells perform several key functions including, but not limited to, maintaining homeostasis, forming the myelin sheath around the neuron axons, and providing support and nutrition to neurons. These different functions are performed by various glial cell types, including astrocytes, oligodendrocytes, microglia and other specialized types. Astrocytes, for example, are the most abundant glial cells and provide metabolic and nutrient support to neurons, help regulate the extracellular ion and neurotransmitter levels, and play a role in the formation and maintenance of the blood-brain barrier, contributing to the overall homeostasis and functioning of the nervous system. Additionally, astrocytes are involved in synaptic communication and participate in processes such as synaptogenesis and synaptic pruning. Oligodendrocytes in the central nervous system function to insulate neurons by producing a fatty substance known as myelin. The myelin sheath enhances the speed and efficiency of nerve impulse conduction along the axons. Microglia, the immune cells of the central nervous system, protect neurons from pathogens and clear away dead neurons through phagocytosis, a process also known as cellular eating. They also contribute to the regulation of inflammation in response to signals of tissue damage or infection in the central nervous system by releasing cytokines and other signaling molecules that modulate the immune response. Despite their overarching function in the support and protection of neurons, glial cells have also been shown to play significant roles in the pathophysiology of many psychiatric and neurodegenerative diseases, such as Alzheimer’s, Parkinson’s Disease and multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.
Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.
Microglial cells, sometimes referred to as microglia, are a type of glial cell that primarily exist within the central nervous system (CNS), notably in the brain and the spinal cord. Classified among the resident immune cells, microglial cells represent about 10% of all cells found within the CNS. These cells are derived from progenitor cells in the yolk sac, which differentiates them from other types of glial cells (such as astrocytes and oligodendrocytes) that are derived from neuroectodermal cell lineages. The primary role of microglial cells is to act as the first and main active form of immune defense in the CNS. They express a vast repertoire of pattern recognition receptors, which allow them to sense and eliminate microbes invading the CNS parenchyma. They represent one of the macrophage populations of the CNS and are responsible for phagocytosis (engulfing and destroying cellular waste or pathogens) in the neural environment. Microglial cells are particularly responsive to pathogens and injuries and change their morphology in reaction to inflammation or insult: In the normal state they are characterized by a ramified shape with small processes; in response to stimuli, some microglia mature and change to an amoeboid shape. Beyond their macrophagic activity, they also perform synaptic pruning during brain development, eliminate unnecessarily produced neurons, and facilitate tissue regeneration and repair. they play integral roles in regulating neural development and supporting cell survival and are important for maintaining tissue homeostasis. While their protective role generally benefits the brain, their over-activation can occasionally lead to neuro-inflammatory diseases, underlining the importance of balanced microglial cell functions. They have been extensively studied for their association with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. These cells originate mainly from the mesoderm of the embryo, which forms connective tissues, muscle, and the circulatory and urinary systems. However, in adults, MSCs are found in multiple tissues, including bone marrow, adipose tissue, the umbilical cord, and dental tissues. The primary function of MSCs is to maintain and repair the tissues in which they are found. When damage occurs, the MSCs are able to migrate to the site of injury, where they aid in regenerating the damaged tissue by differentiating into the required cell type and by secreting growth factors that enhance tissue repair and reduce inflammation. Furthermore, MSCs can also act as immunomodulators, suppressing immune reactions and reducing inflammation, both locally and systemically. Apart from their role in tissue maintenance and repair, MSCs are integral to the field of regenerative medicine and are being investigated for their therapeutic potential in various clinical settings. Owing to their multipotent nature, immunomodulatory activity, and the relative ease of isolation, these cells can be engineered and translated into therapies to treat a variety of diseases, including bone and cartilage defects, liver diseases, heart disorders, and autoimmune diseases, amongst others. They have also been used as vectors for anticancer agents and in cell and gene therapy applications. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.
A fat cell, also known as an adipocyte, is a specialized type of connective tissue cell responsible for the storage of fat in the body. These cells can be found throughout the body, but are most densely located in adipose tissue, such as the subcutaneous tissue beneath the skin and around organs, and act as the body’s energy storage units. The primary function of fat cells is to store energy in the form of fat, also known as triglycerides, for use during periods of caloric deficit. When we consume more calories than we use for energy, our bodies convert the excess energy into fat and store it in adipose tissue. Fat cells also play a role in regulating energy balance by secreting hormones, such as leptin and adiponectin, which help to regulate appetite and metabolism. Fat calls have also been implicated in the development of obesity-related diseases, such as insulin resistance and type 2 diabetes. Finally, fat cells have been found to play a role in the immune system by secreting cytokines, which can either promote or inhibit inflammation depending on the type of cytokine produced. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.
Professional antigen presenting cells, also known as APCs, are essential orchestrators of adaptive immunity. These cells possess the abilities to capture and process antigens and constitutively express MHC class II molecules to facilitate antigen presentation. These cells are able to deliver the three signals to activate naïve T cells, thereby initiating adaptive immunity. Professional APCs include dendritic cells, macrophages, and B cells. Among these, dendritic cells are often considered the predominant APC as they have been demonstrated to activate naïve T cells. Macrophages and B cells also possess antigen-processing machinery and constitutively express MHC class II molecules. Dendritic cells and macrophages obtain antigens via phagocytosis of cells and cell debris, while B cells obtain antigens via the B cell receptor. APCs are responsible for stimulating an appropriate immune response. Following antigen presentation (signal 1), they deliver costimulatory signals (signal 2) and secrete mediators such as cytokines (signal 3) that shape the subsequent immune response. APCs can also induce tolerogenic responses to self-antigens. APCs play important roles in diseases such as cancer and autoimmune diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.
Melanocytes are specialized cells prevalently found in the skin, but also present in the hair follicles, eyes, inner ear, bones, heart, and brain. Their primary function is the synthesis of melanin, a pigment responsible for coloration of skin, hair, and eyes. The presence and distribution of this pigment play a crucial role in the body's defense mechanism against harmful ultraviolet radiation. In addition to melanin production, melanocytes also engage in a variety of other biological functions. They play a fundamental role in the immune response, owing to their ability to present antigens to T cells. Furthermore, they contribute to the maintenance of the skin's homeostasis by regulating processes such as extracellular matrix remodeling and cytokine production. A balance in melanocyte function is pivotal, as dysfunctions often result in dermatological disorders. For instance, the loss of melanocytes or reduction in their function may lead to hypopigmentation conditions such as vitiligo, whereas an abnormal increase could result in hyperpigmentation disorders or melanoma, a dangerous type of skin cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous.
A cell that specializes in controlled release of one or more substances.
A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.
An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption.
Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function.
A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
A neuron that is capable of some hormone secretion in response to neuronal signals.
The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.
A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system.
Chromaffin cells, also known as pheochromocytes, are neuroendocrine cells that are typically located in the adrenal medulla, the innermost part of the adrenal gland, which is situated on top of each kidney. Chromaffin cells are also found in small clusters, known as paraganglia, in various locations throughout the body, including the sympathetic nervous system. They derive their name from their ability to stain a brownish-black color upon exposure to chromic salts, a feature made possible due to their high content of granules rich in catecholamines and catecholamine-related neurotransmitters. The primary function of chromaffin cells is the synthesis and release of catecholamines, specifically epinephrine (adrenaline) and norepinephrine (noradrenaline). These neurotransmitters are vital stress hormones that, when released by the adrenal chromaffing cells into the bloodstream, prepare the body for the 'fight or flight' response. This response can enhance the body's performance in a dangerous situation by increasing heart rate, elevating blood sugar, and increasing blood flow to the muscles. The chromaffin cells in paraganglia are responsible for the local release of catecholamines and play a role in regulating blood pressure and other autonomic functions. In addition to their role in stress response, chromaffin cells also contribute to the body's immune response. They secrete several peptides including antimicrobial peptides, and the discovery of LPS and cytokine receptors on chromaffin cells suggests that the adrenal medulla may participate in some aspects of the immune response. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.
Leydig cells are a testosterone-secreting cell in the interstitial area in the testes of males. They are named after Franz Leydig, a German anatomist who discovered these cells in 1850. Uniquely situated within the soft connective tissue surrounding the seminiferous tubules, Leydig cells form an integral part of the male reproductive system. They are usually polygonal cells characterized by well developed smooth endoplasmic reticulum, high lipid content and a large round nucleus. They are found across mammalian species, including humans. The primary function of Leydig cells is the production of androgens, the male sex hormones, the most notable of which is testosterone. Leydig cells synthesize testosterone from cholesterol through a series of enzymatic reactions. The production and release of testosterone are mainly regulated by the luteinizing hormone (LH) released by the anterior pituitary gland. In response to LH, Leydig cells convert cholesterol into testosterone, which then plays a crucial role in the development and maintenance of primary and secondary male sexual characteristics. These include the formation and maturation of male reproductive organs, onset of spermatogenesis, and the presentation of male secondary sexual traits such as the deepening of the voice, growth of facial hair, development of muscles, and a broadening of shoulders. Apart from testosterone production, Leydig cells also secrete insulin-like factor 3 (INSL3) that is essential for testicular descent during embryonic development in males. Dysregulation or loss of Leydig cells can lead to numerous conditions like testosterone deficiency, infertility, and certain forms of testicular cancer. Although not typical, Leydig cells can regenerate if they are damaged, ensuring the continuous production of testosterone and maintaining male reproductive health. They provide an excellent model to study cell differentiation and hormone regulation, thereby enhancing our understanding of reproductive biology and associated disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated
A cell whose primary function is to shorten.
An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell.
Myofibroblasts are specialized cells predominantly found within the connective tissues of the body, most notably in areas of injury or wound healing. They carry out a crucial role in many biological processes, including tissue repair and fibrosis, wound contraction, and organogenesis. Though similar to fibroblasts, myofibroblasts can be differentiated by their unique morphological features and the presence of specialized protein bundles called stress fibers. Myofibroblasts originate from several cell types based on the physiological condition or the injury context, including local fibroblasts, epithelial cells, and endothelial cells, shedding light onto their plasticity. Upon tissue injury or wound creation, myofibroblasts activate and undergo a transformation process whereby they develop contractile features. They express a type of protein called alpha-smooth muscle actin (α-SMA), allowing them to contract and aid in wound closure. These cells also produce extracellular matrix (ECM) components, primarily collagen, to support and provide structural integrity to the healing tissue. However, while myofibroblasts play a critical role in normal wound healing, their function can be detrimental in certain pathological conditions. For instance, in chronic diseases such as fibrosis or scarring, the extended presence or overactivity of myofibroblasts can lead to the excessive production of ECM and fibrous tissues, leading to hardened, rigid tissues and organ dysfunction. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha.
A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
A somatic cell located in skeletal muscle.
Skeletal muscle cells, or myocytes, are essential for the musculoskeletal system, featuring a striated appearance from tightly packed sarcomeres. These elongated, multi-nucleated cells convert ATP into mechanical energ and are key for voluntary movement and posture. They also are responsible for maintaining body temperature, storing nutrients, and stabilizing joints. Skeletal muscle cells organize themselves tightly into bundles to form muscle fibers. Embedded within each of these cells are thousands of myofibrils, which are made up of the contractile proteins, actin (the thin filament), and myosin (the thick filament). Contraction of a skeletal muscle cell occurs when these myofibrils shorten, a process driven by the sliding of actin and myosin filaments over each other in a mechanism famously known as the sliding filament theory. Additionally, skeletal muscle cells exhibit a high degree of plasticity, which allows for their adaptation in response to alterations in functional demands or damages. They have an innate regenerative capacity due to the presence of satellite cells—quiescent muscle stem cells that reside within the muscle fibers. Upon muscle injury, these satellite cells become activated, proliferate, and differentiate into new muscle cells, thereby contributing to the repair and growth of injured skeletal muscle. With this, skeletal muscle cells serve not only a pivotal biomechanical function but also possess a great capacity for self-healing and regeneration. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).
Smooth muscle cells are a specialized type of muscle cells that are primarily found within the walls of hollow organs such as the intestine, stomach, bladder, uterus, and blood vessels. These cells are an essential component of the autonomic nervous system controling involuntary movements within the body. Smooth muscle cells play a vital role in many physiological processes due to their unique functionality. They can contract and relax in a slow, sustained, and controlled manner to help modulate the size and shape of the lumens of the organs they surround. For example, in the digestive system, coordinated contraction and relaxation of smooth muscle cells propels food along the gastrointestinal tract - a process known as peristalsis. In the blood vessels, the smooth muscle cells, by contracting or relaxing, either constrict or dilate the vessels, which in turn, help regulate blood flow and pressure. On a cellular level, smooth muscle cells possess a single, centrally located nucleus and contain an arranged network of actin and myosin filaments, which are the proteins responsible for muscle contraction. Unlike their counterparts in skeletal or cardiac muscles, these cells lack specific contact points for these filaments, hence the lack of visible striations. Furthermore, the contraction of smooth muscle cells is regulated by hormones and neurotransmitters, such as acetylcholine and norepinephrine, adding an additional layer of complex regulation to these highly specialized cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A cell whose function is determined by the generation or the reception of an electric signal.
A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier.
Sertoli cells, also known as sustentacular cells, are epithelial cells that play a crucial part of the male reproductive system and are situated within the seminiferous tubules of the testes. Functionally, Sertoli cells play diverse and pivotal roles in supporting spermatogenesis, the intricate process of sperm production. To scaffold the developing sperm cells, Sertoli cells morphologically change, interacting directly with the germ cells to provide nutritional support, metabolic regulation, and waste removal, thereby creating an environment conducive to the development of germ cells. In addition to their structural function, Sertoli cells also secrete several bioactive molecules with crucial implications for spermatogenesis. These include anti-mullerian hormone (AMH) during fetal life, inhibin, and androgen binding protein (ABP), as well as several growth factors and transport proteins. They also contribute to the immune-privileged status of the testes by forming the blood-testis barrier, safeguarding sperm antigens from the systemic immune response. Given their extensive roles in maintaining testicular function, impairments in Sertoli cell function can lead to male infertility and are implicated in a range of related disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons.
A cell that moves by its own activities.
Any cell capable of ingesting particulate matter via phagocytosis.
Phagocytes are a heterogeneous group of white blood cells that have the capability to ingest, or ‘phagocytose’, foreign substances, pathogens, and cellular debris with high efficiency, thereby playing a vital role in the immune response. Phagocytes circulate throughout the body, patrolling and guarding against the invasion of pathogens. They are one among many types of cells that originate from hematopoietic stem cells in the bone marrow. Upon detection of an invading microorganism, phagocytes are mobilized by inflammatory mediators (such as bacterial proteins or complement proteins) to the infection site. They recognize surface molecules, specifically antigens, on harmful bacteria or other foreign substances with the help of opsonins, which are proteins that bind to the pathogen and make them more susceptible to phagocytosis. The process of phagocytosis involves the extension of the phagocyte's membrane around the microorganism, completely enclosing it within a microbicidal vacuole, the phagolysosome, which contains various microbicidal chemicals and digestive enzymes such as cathepsins, proteases, lysozymes, and lipases that may be employed to degrade the pathogen. Phagocytes are predominantly neutrophils or monocytes. Neutrophils are the most abundant type of phagocyte and are usually the first to arrive at the site of infection. Monocytes are derived from the bone marrow and can circulate to tissues and mature into local macrophages. Macrophages arrive later at sites of infection and are longer-lived than neutrophils. The process of phagocytosis must be tightly regulated to avoid host tissue damage. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
Macrophages are specialized white blood cells involved in immune responses, inflammation, and tissue repair. Tissue-resident macrophages can be self-renewing and arise from embryo-derived populations. Macrophages can also originate from circulating monocytes that differentiate into macrophages upon migration into body tissues. Macrophages are involved in the detection, phagocytosis, and destruction of bacteria and other pathogens. They are also responsible for engulfing and removing dead cells and debris. Macrophages are also one of the cells that present pathogenic antigens to T cells so that the pathogens may be recognized and killed, or so that an antibody response may be mounted. They can also secrete cytokines, chemokines, and enzymes that further orchestrate the immune response. Tissue-resident macrophages are diverse and heterogenous, likely as a result of the signals received from the tissue environment. The functions of these macrophages are specific to each tissue and contribute to tissue homeostasis. Dysregulation of macrophage functioning may also contribute to the development of various disease processes, such as fibrosis, chronic inflammation, or cancer. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
A lymphocyte of B lineage that is capable of B cell mediated immunity.
A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus.
Stratified squamous epithelial cells are a specific type of epithelial cell that form layers and have a flat shape. These cells are part of the outermost layer of the skin, called the epidermis, and are also found lining surfaces of the body that are subjected to physical or chemical wear and tear, such as the mouth, esophagus, and vagina. The primary role of these cells is to create a barrier that protects underlying tissues from dehydration, abrasion, and infection. The stratified squamous epithelium is able to provide a strong, force-resistant barrier due to the stratified arrangement of the cells; it consists primarily of keratinocytes in various stages of differentiation: The basal layer contains cells that continuously divide and push older cells towards the surface. As the cells move up through the layers, they gradually flatten and become filled with a protein called keratin. In high-abrasion areas like the skin, the outer layers of these cells can become so filled with keratin that they die (they become 'keratinized'), providing an even more robust barrier; eventually, they are shed off in a process known as desquamation. In addition to forming a protective barrier, stratified squamous epithelial cells also play a part in the immune response. They can recognize pathogens, and in response, release chemical signals that attract immune cells to the site of potential infection. Moreover, they also carry out a variety of interactions with the immune system to ensure that invading pathogens cannot penetrate into deeper layers of the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense.
A cell that is specialised to accumulate a particular substance(s).
Any cell that is part of some extraembryonic structure.
An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development.
Trophoblast cells, originating from the blastocyst's outer layer, are highly specialized and pivotal for embryo development. Their crucial roles include facilitating implantation and contributing to the formation of the placenta, an essential organ for fetal nutrition, gas exchange, and waste removal during pregnancy. These cells play a crucial role in implantation by adhering to the uterus lining. Post-implantation, some trophoblast cells differentiate, forming syncytiotrophoblasts. These multi-nucleated cells absorb nutrients, release waste, and secrete hormones, including human chorionic gonadotropin (hCG), sustaining pregnancy. Trophoblast cells also play a crucial role in immune tolerance, preventing the maternal immune system from treating the fetus as foreign. This balance is vital for a healthy pregnancy. Dysfunctional trophoblast cells may lead to complications like miscarriages or preeclampsia, emphasizing their importance in both embryology and reproductive medicine. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
An epithelial cell of the integument (the outer layer of an organism).
Epidermal cells constitute the outermost layer of the skin in animals and have a multifaceted role in maintaining the body's overall homeostasis. They originate from the ectoderm and form the epidermis, a stratified squamous epithelium that mostly consists of keratinocytes in various stages of differentiation. The primary role of these cells is to act as a physical barrier, shielding the internal organs, tissues, and system from dehydration, infection, and other external influences such as UV radiation. The thickness and stratification of the epidermis vary with its location in the body, depending on the specific demand for protective function. One notable characteristic of epidermal cells is their continuous cycle of renewal. The cells are produced in the deepest layer of the epidermis, known as the basal or germinative layer, where they undergo cell division. As new cells form, they gradually push the older cells towards the skin surface. While ascending, these cells undergo a process known as keratinization, where they become filled with keratin, a protein that provides strength and rigidity. By the time they reach the surface, they are essentially dead and filled with keratin, forming a tough, resistant layer that is regularly shed and replaced by newer cells beneath. This entire process, from cell generation to shedding, usually takes around a month. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
prohemocyte (sensu Nematoda and Protostomia)
A cell whose function is determined by its response to an electric signal.
A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).
Dendritic cells, named for their tree-like extensions called dendrites, are a type of immune cell that form a critical bridge between the innate and adaptive immune systems. They are derived from hematopoietic bone marrow progenitor cells and can be found throughout the body poised as sentinels in locations such as the skin, lungs, or liver, as well as immune organs such as the thymus, lymph nodes, or spleen. They can also be found in an immature state in the blood. Dendritic cells serve as antigen-presenting cells, with a primary function of processing and presenting antigens to T-cells to facilitate an immune response. Upon encountering an antigen, dendritic cells engulf the pathogen via phagocytosis and subsequently process the pathogen into antigens. These antigens are then presented on the surface of the dendritic cell in the context of major histocompatibility complex (MHC) molecules. The dendritic cell migrates to the lymph nodes, containing naive T-cells, and presents the antigens to them. This process triggers the activation of cognate T-cells into effector T-cells, which can then recognize and eradicate cells bearing the same antigen. Additionally, the dendritic cells can influence the type of immune response the body will mount. They communicate with T-cells through the use of co-stimulatory molecules and cytokines. Depending on the type of co-stimulatory molecules used and the set of cytokines released, dendritic cells can promote the development of a cellular immune response, dominated by cytotoxic T cells effective against intracellular pathogens such as viruses, a humoral response, mediated by B cells and effective against extracellular bacteria and toxins, or a tolerogenic response. Thus, dendritic cells play a pivotal role in immunity, helping the body to effectively combat infections, prevent autoimmune diseases, and maintain tolerance to healthy self-tissues. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.
Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center.
thyroid stimulating hormone secreting cell
A connective tissue cell of an organ found in the loose connective tissue.
Stromal cells constitute a significant portion of the structural cellular milieu (stroma) that supports the function of parenchymal (functional) cells within an organ. The stroma is the connective, supportive framework of biological tissues with various functions depending on the specific organ and cell type. Stromal cells, derived from the mesenchymal lineage, play crucial roles in creating, maintaining, and repairing the tissue microenvironment in virtually all mammalian organs, making these cells indispensable to biological function. Additionally, stromal cells secrete growth factors, cytokines, and extracellular matrix (ECM) molecules to constitute an interactive cellular network and ensure an optimal environment for the functional cells. Beyond mere structural support, these cells are instrumental in wound healing, inflammation, and maintaining tissue integrity. They may also influence the behavior of other cell types through direct cell-cell interactions or paracrine signaling. Clinically and in research, stromal cells often draw attention due to their interaction with tumors in the cancer microenvironment. Over the past years, the role of stromal cells as facilitators of tumor growth and metastasis has been recognized increasingly. They contribute to cancer progression not only by modulating the ECM but also through the secretion of various bioactive molecules and interacting with immune cells, thereby influencing the immunologic responses to tumors. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A phagocyte in vertebrates that is able to phagocytosis.
The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)
Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
Monocytes are a type of white blood cell that constitute part of the mononuclear phagocyte system. They feature prominently in the human body's first line of defense against foreign substances as a part of the innate immune system. Monocytes are the largest of all circulating leukocytes and are identified by their bean-shaped nucleus. They are produced in the bone marrow and circulate in the bloodstream; in some conditions, they may enter tissues and differentiate into macrophages or dendritic cells or a distinct monocyte-derived cell. Monocytes function effectively as phagocytes, devouring harmful pathogens in the body. They engulf and destroy microbes, foreign substances, cancer cells, and other materials detrimental to the body's well-being. This process, known as phagocytosis, is vital for the body's immune response. Monocytes are also equipped to identify harmful pathogens and alert other immune cells to their presence. This is achieved by producing proinflammatory cytokines that recruit other immune cells to the affected area, amplifying the immune response. Beyond their role in fighting infections, monocytes play an important role in the repair and healing of tissues. After an infection or inflammation subsides, monocytes can transition into different types of cells and assist in healing by clearing dead cells and debris and facilitating tissue regeneration. They are crucial in wound healing, control of microbial growth, and tissue development. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.
A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.
This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12
A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive.
Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+.
A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006).
A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
A cell that stains readily in the anterior pituitary gland.
chromophil cell of anterior pituitary gland
An acidophilic chromophil cell that of the anterior pituitary gland.
acidophil cell of pars anterior of adenohypophysis
acidophil of pars anterior of adenohypophysis
acidophil of pars distalis of adenohypophysis
acidophil cell of pars distalis of adenohypophysis
Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament.
A specialized kidney epithelial cell, contained within a glomerulus, that contains "feet" that interdigitate with the "feet" of other podocytes.
Podocytes are highly specialized, terminally differentiated glomerular visceral epithelial cells that wrap around the capillaries in the kidneys. They play an essential role in kidney function, particularly in the filtration selectivity of the glomerulus. Each podocyte is characterized by a unique architecture with a large cell body, ‘major processes’ extending outwardly from the cell body and ‘foot processes’, also known as pedicels, which surround. the glomerular capillary loops Podocytes represent the last barrier of the glomerular filtration membrane in the kidney. This barrier prevents the leakage of plasma proteins from the blood into the urine, hence maintaining protein homeostasis in the body. The foot processes of the podocytes interdigitate with those from neighboring cells. The cell-cell junctions between the foot processes, the slit-diaphragms, are thought to create a molecular sensor of renal filtration that prevents the passage of macromolecules while allowing water and small solutes to pass. Podocytes also contribute to the glomerular basement membrane by secreting collagen and maintain glomerular endothelial cell fenestration by secreting VEGFA. They have been shown to play a role in inducing cytoskeletal regulation, cell adhesion, and inflammatory response, consistent with their essential function in the kidney. The importance of podocytes is further emphasized by the effects of their damage or loss. Abnormalities in podocytes often result in severe kidney diseases (podocytopathies), including focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Injury to the podocytes can result in "effacement" or flattening of foot processes, leading to increased permeability of the filtration barrier and proteinuria (an excess of serum protein in urine) which is a common symptom of kidney diseases. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
epithelial cell of visceral layer of glomerular capsule
A neuron that is capable of some neurotansmission by glutamate secretion.
A non-terminally differentiated cell that is capable of developing into a muscle cell.
Muscle precursor cells, commonly referred to as myogenic progenitor cells or myoblasts, play a pivotal role in the intricate processes of muscle regeneration and development. As undifferentiated cells, they harbor the potential to evolve into distinct specialized cells, specifically the muscle cell or myocyte. Their crucial contribution lies in guiding the transformation of the mesodermal layer, one of the three primary germ cell layers in the early embryo, into fully developed skeletal muscle tissues during embryonic development. Muscle precursor cells are characterized by their proliferative capacity and rapid differentiation into mature myocytes. They fuse into myotubes, culminating in the formation of muscle fibers. Their responsiveness to signals such as insulin-like growth factors, transforming growth factor-β, and neural inputs enables precise control over their proliferation and differentiation. This regenerative capacity equips them with the ability to repair injured or damaged muscle tissue, a critical function in preserving muscle homeostasis and overall function. These cells also actively contribute to adaptive responses, such as muscle growth and strengthening, in reaction to factors like training or aging. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Epithelial cells derived from neural plate and neural crest.
The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).
A stem cell that can give rise to cell types of the body other than those of the germ-line.
Somatic stem cells, also known as adult stem cells, are undifferentiated cells found throughout the body post-embryonic development. They reside in specialized niches within tissues such as the bone marrow, brain, muscles, skin, and liver. Fundamentally, these cells possess the ability to self-renew, maintaining their numbers, and to generate differentiated cells that replace dying cells and repair damaged tissues. The potency of somatic stem cells varies based on their tissue of origin. For instance, hematopoietic stem cells in the bone marrow exhibit multipotency, giving rise to all blood cell types. Conversely, muscle stem cells display unipotency, generating only muscle cells. Somatic stem cells respond to environmental signals that regulate their quiescence, activation, and differentiation states. In response to tissue injury, they proliferate and differentiate into specific mature cell types to replace lost or damaged cells. Intricate mechanisms ensure a delicate balance between self-renewal and differentiation, guiding tissue maintenance and repair without risking aberrant cell proliferation leading to tumor formation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.
Cardiac muscle cells, also known as cardiomyocytes or cardiac myocytes, are specialized cells that form the heart tissue. These cells are elongated, branched, and contain a single centrally located nucleus. Their anatomy is composed primarily of densely packed myofibrils, which are protein structures that consist of sarcomeres - the fundamental units of muscle contraction. Cardiac muscle cells are united at their ends through specialized junctions known as intercalated discs, which allow the heart to contract in a unified, powerful and rhythmic way. Functionally, cardiac muscle cells are responsible for the heart's consistent pumping action that circulates blood throughout the body. Unlike most cells in the body, cardiac muscle cells spontaneously depolarize and generate action potentials without external stimulation. This unique trait stems from the presence of ion channels in the cells' membrane that allow a cyclic flow of ions across the membrane, which create the electrical impulses necessary for heart contraction. The spread of these electrical signals from one cardiac muscle cell to another - facilitated by the interconnected network made by the intercalated disks - results in a synchronized contraction of the heart muscle. Unlike skeletal muscle cells which can tire and need rest, cardiac muscle cells have to work ceaselessly throughout the entire lifespan, without the opportunity for rest, to ensure continuous circulation of blood. This is made possible through the high volume of mitochondria and a constant supply of oxygen from coronary circulation. In conclusion, cardiac muscle cells, through their unique structure and vital functionality, play a pivotal role in sustaining life by providing the means for blood to reach every cell in the body. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.
A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.
The retinal bipolar neuron is an integral part of the eye, specifically located within the retina. They are secondary neurons in the visual pathway and primarily serve to transmit information from photoreceptor cells, which respond to light, to retinal ganglion cells, which carry the signal to the brain. As such, these cells play a pivotal role in our ability to interpret and perceive visual information. The structure of retinal bipolar neurons is unique and significant to their function. They are termed "bipolar" due to their morphology, having two poles: a single dendrite on one end and an axon on the other. The dendrite end connects to photoreceptor cells (rods or cones), while the axon end synapses with retinal ganglion cells. In the center of the dendrite and axon lies the cell body, which houses the cell's nucleus and other vital organelles. At the functional level, retinal bipolar neurons can be categorized into ON and OFF types based on their response to light. 'ON' bipolar cells are depolarized (electrical potential across the cell membrane decreases) under light conditions, thereby increasing their rate of neurotransmitter release onto the downstream ganglion cells. In contrast, 'OFF' bipolar cells are hyperpolarized (electrical potential increases) in light conditions, decreasing their rate of neurotransmitter release. This dual system allows for a fine-tuned response and the ability to perceive differences in light intensity and contrast, thus creating a nuanced and detailed visual world. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors.
A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.
A cell of the monocyte, granulocyte, or mast cell lineage.
Myeloid leukocytes are a group of immune cells descended from the myeloid lineage. The myeloid lineage constitutes a significant portion of the body's defense system, particularly against microbial pathogens and foreign substances. Myeloid leukocytes originate from hematopoietic stem cells located in the bone marrow. The commitment of a pluripotent hematopoietic stem cell into a myeloid progenitor cell represents the initiation step towards the development of myeloid leukocytes. Once differentiated, these cells contribute diversely to both the innate and adaptive immune responses in the body. Myeloid leukocytes include several distinct cell types based on functionality and structure, encompassing monocytes, macrophages, granulocytes (neutrophils, eosinophils, and basophils), and dendritic cells. Each cell type has specialized functions, occupying a unique role in the body's immune response. For instance, neutrophils are prolific phagocytes—cells that engulf and destroy pathogens—while eosinophils are instrumental in combating multicellular parasites and modulating allergic inflammatory responses. Monocytes, in addition to their phagocytic activities, can enter peripheral tissues and differentiate into macrophages or dendritic cells which are crucial for antigen presentation to T cells. Another critical function of myeloid leukocytes is their involvement in tissue remodeling and repair. For example, macrophages not only play a key role in defending the body but also perform duties essential for wound healing, such as removing dead cells and stimulating tissue repair. In general, myeloid leukocytes participate in the removal of old and damaged cells, an essential process for maintaining good health and homeostasis. Through the orchestration of complex interactions and signal transductions, myeloid leukocytes provide the body with a robust defense system against foreign invaders and participate in maintaining the body's overall balance and function. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A dendritic cell of the myeloid lineage.
Myeloid dendritic cells are a subset of dendritic cells derived from the common myeloid progenitor cell. "Conventional" and "myeloid" DCs are often used interchangeably. In contrast, dendritic cells may also arise from the common lymphoid progenitor. Monocyte-derived dendritic cells may also be induced by inflammatory states. Dendritic cells function as antigen-presenting cells and are able to activate naïve T cells to induce the adaptive immune response. Dendritic cells capture, process, and present antigens derived from pathogens to mount a specific immune response against the invading antigen. Dendritic cells also produce a range of cytokines that help in modulating and recruiting other immune cells during an immune response. Dendritic cells can contribute to immune tolerance by deleting self-reactive T cells or by inducing regulatory T-cells, thereby preventing autoimmunity. Dendritic cells thus are important in orchestrating the adaptive immune response and are pivotal in combating infections and maintaining tolerance to self. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection.
Plasmacytoid dendritic cells (pDCs), initially known as interferon-producing cells, are a unique subpopulation of dendritic cells. Unlike conventional dendritic cells (cDCs), plasmacytoid dendritic cells are characterized by their distinctive plasma cell-like morphology. These cells play vital roles in the innate and adaptive immune response, particularly in the antiviral response. Highly prevalent in the blood and lymphoid organs, pDCs are rare in non-lymphoid tissues, with the exception of inflamed tissues and tumors where they are often recruited. A key role of plasmacytoid dendritic cells is their rapid and robust production of type 1 interferons in response to viral infections. This is crucial for antiviral defense as interferon signals to other immune cells to increase their antiviral defenses. pDCs achieve this by detecting viral nucleic acids in the cytosol through Toll-like receptors (TLRs), specifically TLR7 and TLR9. Upon recognition, these cells quickly produce substantial amounts of interferons, which plays a significant role in the containment of viral replication and the development of acquired antiviral immunity. The potential of plasmacytoid dendritic cells for antigen presentations to naive T cells is relatively low under steady-state conditions. Upon activation by certain stimuli, such as viruses or CpG oligodeoxynucleotides, they have the ability to differentiate into efficient antigen-presenting cells. This transition to activated cells involves an upregulation of major histocompatibility complex (MHC) class II molecules and co-stimulatory molecules, thus allowing them to effectively present antigenic peptides to naive T cells. This crucial function in linking innate and adaptive immunity underlines the importance of pDCs to the overall immune response. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.
Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.
A T cell that expresses an alpha-beta T cell receptor complex.
An alpha-beta T cell that has an immature phenotype and has not completed T cell selection.
Immature alpha-beta T cells represent a subpopulation of T cells in the thymus that are at a development stage in which they are yet to attain full functional status. The term 'alpha-beta' refers to the two distinct types of chains, alpha (α) and beta (β), which form the T cell receptor (TCR) located on the cell's surface. This T cell receptor enables the cell to identify and bind to specific antigens in order to initiate an immune response. Immature alpha-beta T cells arise from lymphoid progenitor cells in the bone marrow and migrate to the thymus, where the maturation of T cells takes place. In the thymus, immature cells (thymocytes) undergo a series of division and differentiation events characterized by the rearrangement of their TCR genes. Upon successful recombination, the cells express a functional alpha-beta TCR on their surface and can then be subjected to a process of selection based on the specificity of the newly expressed receptors. These stages of development are critical to ensuring that only cells with a suitable TCR repertoire survive, ready to be deployed within the immune system. Multiple subsets of immature alpha-beta T cells can be distinguished, depending on the developmental and differentiation stage, including CD4+CD8+ double positive thymocytes, CD4+ or CD8+ single positive thymocytes and immature NK T cells. Immature alpha-beta T cells are critically important to immune function. They constitute the foundation for the adaptive immune system - a fundamental component in combating pathological agents. Once fully matured, these cells can differentiate further into effector T cell types (like helper, cytotoxic, and regulatory T cells), each having unique functional roles in an immune response. The proper development of immature alpha-beta T cells is fundamental to the overall health and efficacy of the immune system. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A alpha-beta T cell that has a mature phenotype.
Mature alpha-beta T cells, also known as αβ T cells, are critical components of the adaptive immune system, responsible for a mediated immune response to pathogens and infected body cells. They derive their name from the alpha and beta chains that make up their characteristic T-cell receptor (TCR), a protein complex that binds to antigens. These cells undergo a maturation process in the thymus, where they learn to recognize self-antigens, thus achieving self-tolerance. Maturation of alpha-beta T cells takes place in the thymus and is tightly controlled by various transcriptional and epigenetic regulators. They develop through several stages from progenitors to mature T cells, from CD4-CD8- double negative cells to CD4+CD8+ double positive cells, until they eventually become CD4+ or CD8+ single positive cells. Once matured, alpha-beta T cells primarily serve as regulators and effectors in an immune response. They are adept at recognizing fragments of antigens, often viruses or bacteria, presented on the surface of other cells via major histocompatibility complex (MHC) molecules. Once they encounter and recognize an antigen, they become activated, proliferate and differentiate into distinct subsets of effector T cells, such as cytotoxic T cells, helper T cells, and Natural Killer (NK) cells, each with a specific role in immune response. Cytotoxic T cells, the effector cells for cell-mediated immunity, are adept at killing cells that have been infected, particularly with viruses. They do this by binding to infected cells and releasing cytotoxic substances which induce apoptosis, or cell death, thus eliminating the infected cells. The main function of NK cells is to kill virally infected cells, and to detect early signs of cancer. Helper T cells do not kill infected cells directly but play a key role in modulating or orchestrating the immune response by releasing cytokines that recruit and regulate other immunity cells such as B cells and macrophages. Therefore, the versatile roles of mature alpha-beta T cells are vital for maintaining the body's successful adaptive immune defenses. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.
The CD4-positive, CD25-positive, alpha-beta regulatory T (Treg) cell serves as a vital element in the mammalian immune system, playing a pivotal role in maintaining immune homeostasis and preventing autoimmunity. This particular T regulatory cell is characterized by CD4 proteins and a high level of CD25 (the alpha chain of the interleukin-2 receptor) on its cell surface. The T-cell receptor (TCR) of these Treg cells is composed of alpha and beta protein chains, making them a subtype of the alpha-beta T cell population that recognize and bind to antigens presented by MHC class II molecules. The primary function of CD4-positive, CD25-positive, alpha-beta Treg cells is regulating immune responses, ensuring that the immune response is proportionate and preventing autoimmunity, maintaining peripheral immune tolerance, and limiting chronic inflammation. They achieve this regulation by suppressing or downregulating the proliferation of effector immune cells, which are activated in response to antigens, to prevent their excessive or uncontrolled activity. CD4-positive, CD25-positive, alpha-beta Treg cells can suppress immune responses via a variety of mechanisms, including the release of inhibitory cytokines, in particular IL-10 and TGFβ, or through cytolysis of effector immune cells (e.g. antibody-producing B cells) involving perforin and granzymes. They can also modulate the maturation or function of dendritic cells, which are key antigen-presenting cells, and thereby reduce their ability to stimulate effector T cells. This downregulation also suppresses effector T cell functions against self-antigens—proteins that are innate to the body—to prevent autoimmunity. In essence, Treg cells act as a policing force within the immune system to maintain balance and prevent overreaction which can potentially lead to damaging effects. Besides their crucial role in preventing autoimmunity, CD4-positive, CD25-positive, alpha-beta Treg cells contribute to other functions such as tumor immune evasion, maternal-fetal tolerance, and transplantation tolerance. By suppressing the cytotoxic T cell response, these cells may inadvertently help tumor cells evade destruction, contributing to cancer progression. However, this characteristic can be potentially manipulated for therapeutic applications in immune-related diseases or transplantation, further highlighting the potential and importance of CD4-positive, CD25-positive, alpha-beta regulatory T cells in immune regulation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte
CD4-positive, CD25-positive, alpha-beta regulatory T-cell
CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte
This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype.
CD4-positive, CD25-positive, alpha-beta regulatory T cell
A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors.
Double-positive (DP), alpha-beta thymocytes are a developmental stage in the production of mature alpha-beta T cells. These DP cells are found in the thymus. They are named 'double-positive' due to their expression of both CD4 and CD8 co-receptors on their surface, a characteristic that distinguishes them from other types of thymocytes. ‘Alpha-beta' refers to the type of T cell receptor (TCR) they express, differentiating them from gamma-delta T cells. In the preceding double negative (DN) phase, cells undergo an important developmental checkpoint called β-selection in which the β-chain of the TCR is rearranged and only cells expressing functional β-chains, combined with a surrogate α chain forming the pre-TCR, move forward in development. In the DP phase, cells downregulate expression of the surrogate α chain which is replaced by the α chain, which also undergoes gene rearrangements. This developmental stage is characterized by thymic selection processes that ultimately shape the T cell repertoire. Cells with nonfunctional TCRs undergo death by neglect, while cells expressing TCRs that bind strongly to self-peptides presented in the context of major histocompatibility complex (MHC) molecules are removed by negative selection, and cells that express TCRs that weakly interact with self-MHC are kept via positive selection. This ensures that the resulting mature T cells are able to recognize self-MHC without responding too strongly, which could result in autoimmune reactions. The CD4 and CD8 coreceptors play an important role in the selection processes, and the class of self-MHC that was recognized by the cell will dictate whether CD4 or CD8 expression remains on the cell while the other is downregulated. CD4 corresponds to the recognition of MHC class II while CD8 corresponds to MHC class I. The cell will then proceed into the single-positive (SP) phase and ultimately produce mature alpha-beta T cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
double-positive, alpha-beta immature T lymphocyte
Thymocytes of this stage are undergoing positive and negative selection.
A precursor B cell is a B cell with the phenotype CD10-positive.
Precursor B cells, often abbreviated as pre-B cells, represent an intermediary stage in the development of B cells, the white blood cells that play a crucial role in the body’s adaptive immunity system. They arise from early lymphoid progenitors in the bone marrow, representing a critical point in B cell development between a pro-B cell and an immature B cell. They differ from mature B cells as they still populate the bone marrow and have yet to fully develop the distinctive B cell receptor complex. The primary function of precursor B cells is to undergo proliferation and rearrange their immunoglobulin light chain gene regions which ultimately forms part of the B cell receptor (BCR), an event crucial to B lymphocyte development. This process is closely monitored by the body's quality control mechanisms, ensuring all newly produced B cells have functional (and not self-reactive) receptors. This receptor editing and checking system helps to prevent autoimmune diseases, triggered when immune cells mistakenly attack the body's own cells. Critical mutations required for the maturation of the BCR happen in stages while the cell is a pre-B cell. Pre-B cells are initially characterized as stage called "large pre-B cells," during which proliferation occurs. Additionally, heavy chain recombination is completed and the cell undergoes a checkpoint in which only cells with a functional heavy chain continue to develop. Afterwards, they transition into a "small pre-B cell" phase, where heavy chain rearrangement ends, and light-chain rearrangement begins. Once the B cell receptor is fully formed following heavy and light chain rearrangement, the cell is considered an immature B cell and leaves the bone marrow. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
A myeloblast committed to the basophil lineage.
The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow.
A progenitor cell restricted to the lymphoid lineage.
Note that this is a class of cell types, not an identified single cell type.
lymphoid lineage restricted progenitor cell
A progenitor cell restricted to the myeloid lineage.
myeloid lineage restricted progenitor cell
An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low.
A leukocyte with a single non-segmented nucleus in the mature form.
A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
Tissue-resident macrophages refer to a heterogeneous group of specialized macrophages that permanently reside within specific tissues, performing integral functions essential to tissue homeostasis. Most tissue-resident macrophages arise from embryonic populations and self-renew. Some macrophages may also originate from circulating monocytes released from the bone marrow and differentiate into macrophages upon entering tissue. Tissue-resident macrophages are given different names depending upon the tissue in which they reside, such as Kupffer cells in the liver, alveolar macrophages in the lungs, and microglia in the brain. Tissue-resident macrophages are responsible for the phagocytosis of pathogenic substances and dead cells, serving as part of the foremost line of defense against invading microorganisms. They utilize pattern recognition receptors to identify foreign substances and function as antigen-presenting cells to induce adaptive immunity. Additionally, they produce a variety of cytokines and chemokines, signaling molecules that recruit additional immune cells to sites of infection or inflammation and regulate immune responses. In addition to their immunological roles, tissue-resident macrophages also have tissue-unique functions. In the liver, Kupffer cells play a role in iron homeostasis, while in the brain, microglia are responsible for synaptic pruning during development. In the lungs, alveolar macrophages are involved in the removal of airborne particles and debris. This underscores their significance in not only providing pathological immunity but also in maintaining the optimal function of the tissues in which they reside. " (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A tissue-resident macrophage found in the central nervous system.
Central Nervous System (CNS) macrophages represent an integral part of the brain's innate immune system. These immune cells play crucial roles in maintenance and regulation, homeostasis, and disease response, thereby helping in the overall cognitive functioning of an organism. There are different macrophage populations in the CNS, often classified into microglial cells, which reside in the parenchyma, and non-parenchymal macrophages at the interface between the brain and the periphery, including the perivascular spaces, the choroid plexus, and the meninges. CNS macrophages are derived from erythromyeloid progenitors in the yolk sac. CNS macrophages have distinct morphologies: Meningeal and perivascular macrophages have a more elongated shape than microglia, which are characterized by a small cell body with fine processes; in contrast, choroid plexus macrophages typically have a stellate shape. Microglia are the most abundant abundant mononuclear phagocytes and have been shown to play a number of physiological roles, including proinflammatory and anti-inflammatory functions, synaptic pruning and remodeling, and apoptotic cell removal through phagocytosis. Non-parenchymal CAMs primarily support the barrier function against external antigens. Meningeal macrophages have been shown to respond to peripheral microbial challenges and to protect the brain against fatal viral infection. CNS macrophages are also involved in the initiation and progression of many neurological diseases, such as Alzheimer's disease and Parkinson's disease as well as multiple sclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function.
A effector T cell that provides help in the form of secreted cytokines to other immune cells.
A lymphocyte of B lineage with the commitment to express an immunoglobulin complex.
Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
Conventional dendritic cell is a dendritic cell that is CD11c-high.
Conventional dendritic cells (cDCs) are primarily responsible for processing antigens and presenting them to T cells to initiate an immune response. Also known as classical dendritic cells, cDCs originate from hematopoietic stem cells in the bone marrow, maturing in peripheral tissues. They are characterized by their distinct morphology, which features a central body with numerous branching extensions known as dendrites. These cells have a pivotal role in adaptive immunity, bridging the gap between the innate and adaptive immune responses. They achieve this by capturing, processing, and presenting antigens to naive T-cells in the secondary lymphoid organs. This antigen presentation, in conjunction with co-stimulatory signals provided by the cDCs, instructs the T cells whether to mount an immune response against the antigen. cDCs are also very effective in the cross-presentation of antigens in the context of major histocompatibility complex (MHC) I, thereby activating CD8+ T cells an initiating a cytotoxic T cell response. In addition to their role in antigen presentation, cDCs have other important functions in maintaining immune homeostasis. They can perceive signals from the surrounding tissue microenvironment, responding to inflammation, and influencing or even polarizing T cell differentiation into various effector subtypes. Importantly, while cDCs are often associated with immunogenic responses, they also play a crucial role in immune tolerance, particularly towards self-antigens, thereby preventing autoimmune reactions. In conclusion, conventional dendritic cells serve as the sentinels of the immune system, monitoring for threat signals and coordinating the appropriate immune response. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.
A cell that is maintained or propagated in a controlled artificial environment for use in an investigation.
'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells.
A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.
hematopoietic lineage restricted progenitor cell
A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.
This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
hematopoietic oligopotent progenitor cell
An epithelial cell derived from endoderm.
An epithelial cell derived from ectoderm.
Epithelial cell derived from mesoderm or mesenchyme.
A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.
MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.
An epithelial cell found in the lining of the stomach.
An epithelial cell of the stomach. This cell produces mucous.
A columnar epithelial mucous secreting cell located in the neck of the gastric glands. These cells have numerous apical secretory vesicles containing mucins and a basally displaced nucleus. The mucous they secrete is distinct histochemically from that of the surface mucous cells of stomach.
A cell that is part of the nervous system.
A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest.
A T cell that expresses a T cell receptor complex and has completed T cell selection.
A T cell that has not completed T cell selection.
A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both.
An epithelial cell of the kidney cortex.
A cell of the seminiferous tubule epithelium.
A glandular epithelial cell that is part of the stomach.
Any hematopoietic cell that is a precursor of some other hematopoietic cell type.
A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.
Progenitor cells are a specialized type of biological cell that can differentiate into specific cell types. While akin to stem cells in their differentiation capacity, progenitor cells are more limited in divisions and are already somewhat specialized. They can divide a restricted number of times and differentiate into a few closely related cell types, unlike stem cells with broader differentiation potential. Primarily, progenitor cells play key roles in repairing and maintaining body tissues. During embryonic development, they significantly contribute to organogenesis, forming major organs. In adults, progenitor cells function as a repair system, replenishing lost cells in tissues like skin, blood, or the gut lining. Various types of progenitor cells have distinct roles; for instance, neuronal progenitor cells specialize into different brain cells, while myeloid progenitor cells develop into red and white blood cells and platelets. Disruptions to progenitor cells can lead to diseases, emphasizing their vital role in tissue homeostasis. Their unique properties also make them valuable in therapeutic approaches like tissue engineering and regenerative medicine. Researchers are exploring methods to direct these cells towards specific types to replace cells lost or damaged in conditions like spinal cord injuries, diabetes, and heart disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
A cell that, by division or terminal differentiation, can give rise to other cell types.
Precursor cells represent an intermediate stage between an undifferentiated stem cell and a fully specialized cell. Possessing the ability to differentiate into one or multiple specialized cell types, precursor cells exhibit partial stem cell characteristics. This differentiation is vital for various aspects of biological development and maintenance. Neural precursor cells, for example, can give rise to neurons, astrocytes, and oligodendrocytes, while hematopoietic precursor cells can transform into different blood cell types. This orchestrated process aligns with the body's metabolic activities, ensuring the production of the right cell types in response to physiological needs. Moreover, the study of precursor cells has become a promising field in regenerative medicine and cellular therapies. However, it's essential to note that precursor cells have a more limited self-renewal capacity compared to stem cells, and once they start differentiating along a specific cell lineage, the process is often irreversible. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.
Any renal cortical epithelial cell that is part of some renal corpuscle.
The kidney corpuscle cell, also known as a renal corpuscle cell, is a crucial component of the renal corpuscle, a structure within the kidney responsible for initiating the blood filtration process to produce urine. Comprising the glomerulus and Bowman's capsule, the renal corpuscle relies on these cells to play a central role in the kidney's filtration system. During blood filtration, kidney corpuscle cells create an interface between blood and filtrate, allowing the removal of waste while retaining essential components in the bloodstream. The cells perform this through a combination of physical and specialized properties that are critical to an accurate filtering process. Some of these cells, such as endothelial cells in the glomerulus, are characterized by their fenestrations that help facilitate the filtration of plasma from the blood. These cells are specialized to permit the passage of fluid, while blocking the passage of blood cells and large proteins. Another type of corpuscle cell, the podocyte in Bowman's capsule, contributes with tentacle-like protrusions and slit diaphragms for further plasma filtration. Moreover, kidney corpuscle cells are implicated in disease states. Damage or pathology affecting these cells can reduce the kidney's filtering capacity, leading to kidney disease. For example, podocyte damage may cause protein leakage into urine (proteinuria), an early sign of kidney issues. Beyond routine filtration, renal corpuscle cells are vital for overall kidney health, serving as a crucial indicator for potential kidney-related problems. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules.
secretory epithelial cell
A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.
Any neuron that is part of a central nervous system.
A neuron that is part of a peripheral nervous system.
A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it.
This atom is closely related to ChEBI's atom, but not exactly equivalent to.
atom
A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom.
This molecular entity is different than ChEBI's 'molecular entity'.
We would like to have cardinality restrictions on the logic, but there are some technical limitations.
molecule
A part of a multicellular organism that is a collection of cell components that are not all contained in one cell.
gross anatomical part
A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome
'Maximal functionally integrated unit' is intended to express unity, which Barry considers synonymous with BFO 'object'.
Includes virus - we will later have a class for cellular organisms.
organism
A material entity processed by human activity with an intent to produce it.
In the COB 2024 workshop there was much disagreement about this label.
processed material entity
completely executed planned process
A molecule that consists of nucleotides (unmodified nucleotide residues and/or modified nucleotide residues) linked by phosphodiester bonds or derivatives of such bonds.
nucleic acid chain
A complex of two or more molecules that are not covalently bound.
complex of molecules
A process that is initiated by an agent who intends to carry out a plan to achieve an objective through one or more actions as described in a plan specification.
planned process
failed planned process
A completely executed planned process that intends to output material entities from input material entities
material processing
characteristic
A process during which an organism comes into contact with another entity.
exposure of organism
A processed material entity which is designed to be capable of a process.
device
Differentiating cell composing the aggregate that has acquired adhesive properties.
Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC.
A disease that involves errors in metabolic processes of building or degradation of molecules.
metabolic disease
disease of metabolism
A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.
haemophagocytic syndrome
Xref MGI. MESH:C537250 added from NeuroDevNet [WAK].
hemophagocytic lymphohistiocytosis
A primary ciliary dyskinesia that is characterized by sinusitis, bronchiectasis and situs inversus with dextrocardia resulting from dysfunction of the cilia during embryologic development.
Kartagener's syndrome
Kartagener syndrome
A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).
sensory system disease
A genetic disease that is the result of one or more abnormal alleles and may be dominant, semi-dominant, or recessive.
monogenic disease
An intestinal disease that is characterized by predisposition to colon cancer.
adenomatous polyposis of the colon
OMIM mapping confirmed by DO. [SN].
familial adenomatous polyposis
A syndrome that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair.
xeroderma pigmentosum
A syndrome that is characterized by global growth retardation of the muscle, liver, brain and eyes as well as constrictive pericarditis and has_material_basis_in mutations in the TRIM37 gene.
MUL
Mulibrey growth disorder
Muscle-Liver-Brain-Eye Nanism
PERICARDIAL CONSTRICTION AND GROWTH FAILURE
Perheentupa Syndrome
mulibrey nanism
A syndrome characterized by a combination of hearing loss and visual impairment.
Xref MGI. OMIM mapping confirmed by DO. [LS].
Usher syndrome
A sphingolipidosis that is characterized by leukodystrophy, ichthyosis, skeletal abnormalities and shortened life expectancy and has_material_basis_in mutation in the SUMF1 gene that results in deficiency in multiple sulfatase enzymes.
Sulfatidosis, Juvenile, Austin Type
multiple sulfatase deficiency disease
mucosulfatidosis
A peroxisomal disease that is characterized by neurological impairment, intellectual disability, hepatosplenomegaly and ichthyosis and results from the accumulation of very long chain fatty acids and phytanic acid, secondary to mutation in the PEX genes.
infantile phytanic acid storage disease
infantile Refsum disease
A rickets that has_material_basis_in X-linked mutations in the PHEX gene that lead to increased circulating levels of FGF-23, a phosphate-regulating hormone (phosphatonin), that leads to reduced renal phosphate reabsorption and consequently abnormal bone mineralization.
Hypophosphatemia, Vitamin D-Resistant Rickets
Vitamin D-Resistant Rickets, X-Linked
X-linked dominant hypophosphatemic rickets
X-linked hypophosphatemia
hypophosphatemic rickets X-linked dominant
X-linked hypophosphatemic rickets
A peroxisomal disease that is characterized by cortical atrophy, microcephaly, dysmorphic facies, muscular hypotonia and intellectual disability and has_material_basis_in mutation in the MVK gene that results in deficiency of mevalonate kinase and impaired cholesterol. biosynthesis.
Mevalonate Kinase Deficiency
mevalonic aciduria
A lysosomal storage disease that is characterized by delayed speech at 2-3 years of age, has_material_basis_in mutations in the AGA gene that result in the absence or shortage of the aspartylglucosaminidase enzyme in lysosomes, preventing the normal breakdown of glycoproteins.
aspartylglucosaminidase deficiency
aspartylglycosaminuria
glycosylasparaginase deficiency
aspartylglucosaminuria
An osteochondrodysplasia that has_material_basis_in heterozygous mutation in the SOX9 gene on chromosome 17q24 and that is characterized by congenital shortness and bowing of long tubular bones, especially in the lower extremities, as well as by hypoplastic scapulae, narrow iliac wings, and nonmineralized thoracic pedicles.
Acampomelic Campomelic Dysplasia
campomelic dysplasia
A lipid storage disease that is characterized by abnormalities in swallowing, cognition, joint function, and central nervous system due to a deficiency in the enzyme ceramidase that results in sphingolipids deposition.
Farber disease
N-laurylsphingosine deacylase deficiency
acid ceramidase deficiency
Farber lipogranulomatosis
A syndrome that is characterized by protuberant and low-set ears, flaring nostrils, thick lips, enlarged secondary sex organs and overwhelming insulin resistance and has_material_basis_in mutation within the INSR gene causing abnormalities in the insulin receptor.
Leprechaunism
Donohue syndrome
A childhood electroclinical syndrome that is characterized by frequent seizures and intellectual disability that present in early childhood.
Lennox syndrome
Lennox-Gastaut syndrome
An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.
nonsyndromic hearing loss
nonsyndromic hereditary hearing loss
nonsyndromic deafness
A physical disorder that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development.
Xref MGI. OMIM mapping confirmed by DO. [SN].
orofacial cleft
A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together.
Jarcho-Levin syndrome
costovertebral dysplasia
spondylothoracic dysostosis
spondylothoracic dysplasia
spondylocostal dysostosis
An Ewing sarcoma that arises from the soft tissues of the chest wall that tend to recur locally and not widely disseminated.
Askin tumor
Askin tumour
Askin's tumour
Askin's tumor
An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.
respiratory system cancer
An organ system benign neoplasm that is located_in reproductive system organs.
reproductive organ benign neoplasm
A syndrome characterized by abnormal pigmentation of the skin, hair and eyes.
oculocutaneous albinism
A vascular disease that is characterized by generalized calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall.
generalized arterial calcification of infancy
idiopathic infantile arterial calcification
infantile arteriosclerosis
arterial calcification of infancy
A congenital heart septal defect characterized by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the atrial septum and the muscular portion of the ventricular septum, thus allowing extra blood to circulate the lungs.
AVCD
AVSD
ECD
atrioventricular canal defect
endocardial cushion defect
atrioventricular septal defect
A Cowden syndrome that is characterized by macrocephaly, multiple noncancerous tumors and hamartomas, and dark freckles on the penis, and has_material_basis_in heterozygous germline mutation in the PTEN gene on chromosome 10q23.
PHTS
PTEN hamartoma tumor syndrome
PTEN hamartoma tumour syndrome
BRRS
Bannayan-Riley-Ruvalcaba syndrome
Bannayan-Zonana syndrome
Lhermitte-Duclos disease
Proteus-like syndrome
Riley-Smith syndrome
Ruvalcaba-Myhre-Smith syndrome
SOLAMEN syndrome
dysplastic cerebellar gangliocytoma
dysplastic gangliocytoma of cerebellum
segmental overgrowth, lipomatosis, arteriovenous malformation, and epidermal nevus syndrome
Cowden syndrome 1
A cancer that is classified based on the organ it starts in.
organ system cancer
A cancer that is classified by the type of cell from which it is derived.
cell type cancer
An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep.
electro-clinical syndrome
electroclinical syndrome
An electroclinical syndrome with onset in childhood between one and 12 years of age.
JA:Epilepsy Genetics Kiel
childhood electroclinical syndrome
A monogenic disease that has_material_basis_in mutations in genes on the X chromosome.
X-linked monogenic disease
An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease.
autosomal dominant disease
An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop.
autosomal recessive disease
A monogenic disease that has_material_basis_in a mutation on one of the non-sex chromosomes.
autosomal genetic disease
A large B-cell lymphoma that is consisting of medium-sized to large B cells with a diffuse growth pattern.
DLBCL
diffuse large B-cell lymphoma
A hereditary ataxia that is characterized by ataxia originating in the cerebellum.
cerebellar ataxia
A non-syndromic intellectual disability characterized by a X-linked inheritance pattern.
non-specific X-linked mental retardation
Xref MGI.
non-syndromic X-linked intellectual disability
A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgyny manifestations resulting from steroidogenic enzyme deficiency.
adrenal hyperplasia 1
congenital lipoid adrenal hyperplasia
lipoid CAH
congenital adrenal hyperplasia
A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.
SA node
sinuatrial node
sinoatrial node disease
A vascular disease that is located_in an artery.
artery disease
A colorectal carcinoma that derives_from epithelial cells of glandular origin.
colorectal adenocarcinoma
A cerebellar ataxia that has_material_basis_in autosomal recessive inheritance.
autosomal recessive cerebellar ataxia
An autoimmune hypersensitivity disease located_in the central nervous system.
autoimmune disease of central nervous system
A severe combined immunodeficiency that is a X-linked SCID that has_material_basis_in mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.
SCID-X1
XSCID
gamma chain deficiency
thymic epithelial hypoplasia
OMIM mapping confirmed by DO. [LS].
X-linked severe combined immunodeficiency
A combined T cell and B cell immunodeficiency that has_material_basis_in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.
LIG4 Syndrome
DNA ligase IV deficiency
A hyper IgM syndrome that has_material_basis_in mutation in the TNFRSF5 gene, resulting in type 3 hyper-IgM immunodeficiency that is characterized by an inability of B cells to undergo isotype switching, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
CD40 deficiency
HIGM3
hyper-IgM syndrome due to CD40 deficiency
type 3 hyper-IgM immunodeficiency
immunodeficiency with hyper IgM type 3
An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system.
autoimmune disease of musculoskeletal system
A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.
developmental disorder of mental health
A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.
specific developmental disorder
An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue.
autoimmune disease of skin and connective tissue
A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.
Pervasive Child Development Disorders
pervasive development disorder
pervasive developmental disorder
A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.
lymphoid cancer
lymphoma
A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma.
non-Hodgkin lymphoma
A peripheral T-cell lymphoma that has_material_basis_in a mutation of T cells.
cutaneous T cell lymphoma
cutaneous T-cell lymphoma
primary cutaneous T-cell non-Hodgkin lymphoma
A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize.
benign neoplasm
An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.
lymphatic system cancer
A thoracic benign neoplasm that is characterized by lack of malignancy.
breast benign neoplasm
An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.
immune system cancer
A benign neoplasm that is classified by the organ system from which it is arising from.
organ system benign neoplasm
A reproductive organ benign neoplasm that is characterized by a lack of malignancy located_in the male reproductive system.
male reproductive organ benign neoplasm
A nervous system benign neoplasm that is characterized by lack of malignancy.
central nervous system benign neoplasm
An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.
cardiovascular organ benign neoplasm
An organ system benign neoplam that is located_in the thoracic cavity.
thoracic benign neoplasm
An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.
skeletal system cancer
musculoskeletal system cancer
A brain cancer that has_material_basis_in glial cells.
lower grade glioma
brain glioma
An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.
nervous system benign neoplasm
A nervous system cancer that is located in the sensory system.
sensory system cancer
A disease of anatomical entity that is located_in the thoracic cavity.
thoracic disease
An organ system cancer that is located_in the skin, hair and nails.
integumentary system cancer
A disease of metabolism that has_material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.
acquired metabolic disease
An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids.
organic acid metabolism disorder
organic aciduria
organic acidemia
An inflammatory bowel disease that involves inflammation located_in colon.
colitis
An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17.
acute myeloblastic leukaemia type 3
acute myeloblastic leukemia type 3
acute myeloid leukaemia M3
acute myeloid leukemia M3
acute promyelocytic leukaemia
acute promyelocytic leukemia
A syndrome associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia.
ciliopathy
A chromosomal disease that has_material_basis_in partial deletion of chromosomes.
chromosomal deletion syndrome
A bone disease that is located_in the spine.
spinal disease
An ichthyosis that is characterized by autosomal recessive inheritance and abnormal skin scaling over the whole body due to a defect in keratinization.
ARCI
lamellar ichthyosis
non bullous congenital ichthyosiform erythroderma
autosomal recessive congenital ichthyosis
A central nervous system benign neoplasm that derives_from endothelial cells and that is located_in the brain.
cerebral arteriovenous malformation
intracranial arteriovenous malformation
arteriovenous malformations of the brain
A generalized dystomia characterized by autosomal dominant inheritance of dystonia usually presenting initially as focal, typically in the limbs, but often generalizes with age that has_material_basis_in heterozygous mutation in the TOR1A gene on chromosome 9q34.
dystonia musculorum deformans
torsion dystonia 1
A methylmalonic acidemia characterized by accumulation of methylmalonic acid in the blood that is unresponsive to vitamn B12 therapy and that has_material_basis_in mutation in the MUT gene on chromosome 6p12.3.
methylmalonic acidemia due to methylmalonyl-CoA mutase deficiency
methylmalonic aciduria mut type
vitamin B12-unresponsive methylmalonic aciduria
methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
A methylmalonic acidemia characterized by autosomal recessive inheritance, defects in the synthesis of AdoCbl, vitamin B12 therapy responsiveness and that has_material_basis_in homozygous or compound heterozygous mutation in the MMAB gene on chromosome 12q24.
methylmalonic aciduria cblB type
methylmalonic aciduria, vitamin B12-responsive, due to defect in synthesis of adenosylcobalamin, cblB complementation type
methylmalonic acidemia cblB type
A syndrome characterized by ectrodactyly, ectodermal dysplasia, and orofacial clefts (cleft lip-palate).
Rudiger syndrome 1
Walker-Clodius syndrome
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome
ectrodactyly-ectodermal dysplasia-clefting syndrome
EEC syndrome
An osteochondrodysplasia characterized by abnormal shortening of the forearms and lower legs, abnormal misalignment of the wrist (Madelung deformity of the wrist), and associated short stature and has_material_basis_in heterozygous defects in the pseudoautosomal genes SHOX or SHOXY or by deletion of the SHOX downstream regulatory domain.
Leri-Weill dyschondrosteosis
A syndrome that is characterized by megacystis with disorganized detrusor muscle, cryptorchidism, and thin abdominal musculature with overlying lax skin and that has_material_basis_in homozygous mutation in the CHRM3 gene on chromosome 1q43.
Eagle-Barrett syndrome
Obrinsky syndrome
abdominal muscle deficiency syndrome
triad syndrome
prune belly syndrome
A B-cell lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.
Waldenstroem's macroglobulinemia
Waldenstrom Macroglobulinemia
lymphoplasmacytic lymphoma with IgM gammopathy
Lymphoplasmacytic lymphoma, also known as Waldenstrom macroglobulinemia.
lymphoplasmacytic lymphoma
A bone marrow cancer that is formed of any one of the bone marrow cells belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages.
myeloid neoplasm
A Niemann-Pick disease characterized by onset in infancy and involvement of neurological tissues that has_material_basis_in an autosomal recessive mutation of the SMPD1 gene on chromosome 11p15.4.
Niemann-Pick disease type A
A Niemann-Pick disease characterized by visceral involvement only and survival into adulthood that has_material_basis_in an autosomal recessive mutation of the SMPD1 gene on chromosome 11p15.4.
Niemann-Pick disease type B
A Niemann-Pick disease that has_material_basis_in an autosomal recessive mutation of the NPC1 gene on chromosome 18q11.2.
NPC1
Niemann-Pick disease type C1
An electroclinical syndrome characterized by the occurrence of generalized onset seizures that cause lapses in awareness, begin and end abruptly, typically last only a few seconds and are associated with abnormal spike-wave discharges as seen by electroencephalogram.
absence epilepsy
A cerebellar disease that is characterized by a cerebellum that is smaller than usual or not completely developed.
cerebellar hypoplasia
A syndrome characterized by the presence of multiple benign growths called hamartomas and an increased risk of cancer.
hamartoma syndrome
A musculoskeletal system disease that affects the muscles.
muscular disease
A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.
skeletal disease
bone disease
A bone disease that results_in formation or resorption abnormalities located_in bone.
bone remodeling disease
A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.
bone development disease
A X-linked monogenic disease that has_material_basis_in dominant inheritance.
X-linked dominant disease
A X-linked monogenic disease that has_material_basis_in recessive inheritance.
X-linked recessive disease
A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes.
chromosomal disease
A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.
congenital disorder
physical disorder
An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism.
hypochondroplasia
An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism.
SPONDYLOEPIPHYSEAL DYSPLASIA, PSEUDOACHONDROPLASTIC
pseudoachondroplastic dysplasia
pseudoachondroplasia
A lipid metabolism disorder that is characterized by a deficiency of the enzyme medium chain acyl-CoA dehydrogenase that results in the inability to convert medium chain fatty acids to energy, particularly during fasting.
medium chain acyl-CoA dehydrogenase deficiency
A lipid metabolism disorder that is characterized by deficiency of the enzyme very long chain acyl-CoA dehydrogenase that results in the inability to convert very long chain fatty acids.
VLCAD deficiency
very long chain acyl-CoA dehydrogenase deficiency
A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa.
colorectal carcinoma
A lipid storage disease characterized by dyslipidemia and accumulation of cholesteryl esters and triglycerides within various organs that has_material_basis_in homozygous or compound heterozygous mutation in the LIPA gene on chromosome 10q23.31.
LAL deficiency
LAL-D
lysosomal acid lipase deficiency
A cystic kidney disease that is characterized by the growth of fluid-filled cysts in the kidneys that reduces kidney function and may lead to kidney failure.
polycystic kidney disease
A gastrointestinal system cancer that is located_in the hepatobiliary system.
hepatobiliary system cancer
A thyroid gland carcinoma that derives_from epithelial cells of glandular origin.
thyroid gland adenocarcinoma
A thyroid gland adenocarcinoma characterized by extensive evidence of follicular cell differentiation.
differentiated thyroid gland carcinoma
differentiated high-grade thyroid carcinoma
A polygenic disease that is characterized by expression of a phenotype that requires the presence of pathogenic variants in two different genes.
digenic disease
An oculocutaneous albinism that has_material_basis_in an autosomal recessive null mutation of the SLC24A5 gene on chromosome 15q21.1.
oculocutaneous albinism type VI
A bone cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm.
bone sarcoma
A syndrome that has_material_basis_in mutations in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction.
RAS/mitogen-activated protein kinase syndrome
RASopathy
An acute myeloid leukemia that is characterized by a predominant immature erythroid population.
acute erythroid leukemia
A Cockayne syndrome that is characterized by very severe prenatal developmental anomalies including microcephaly, congenital cataracts, severe mental retardation, facial dysmorphism, and arthrogryposis.
cerebrooculofacioskeletal syndrome
A non-Hodgkin lymphoma of T-cell lineage.
T-cell non-Hodgkin lymphoma
A syndrome that is characterized by the premature onset of age-related pathologies.
progeroid disease
progeroid syndromes
progeroid syndrome
A myopathy that is characterized by hypotonia and weakness, usually present from birth.
congenital myopathy
A syndrome characterized by neuromyotonia and chondrodysplasia that has_material_basis_in hypomorphic mutations in the HSPG2 gene on chromosome 1p36.
Aberfeld syndrome
Burton skeletal dysplasia
Burton syndrome
Catel-Hempel syndrome
Catel-Hempel type dysostosis enchondralis metaepiphysaria
Schwartz-Jampel syndrome type 1
Schwartz-Jampel-Aberfeld syndrome
myotonic chondrodystrophy
myotonic myopathy, dwarfism, chondrodystrophy, ocular and facial anomalies
osteochondromuscular dystrophy
Schwartz-Jampel syndrome 1
A vitamin metabolic disorder characterized by progressive spino-cerebellar ataxia, loss of proprioception, areflexia, and marked deficiency in vitamin E that has_material_basis_in homozygous or compound heterozygous mutation in the TTPA gene on chromosome 8q12.
ataxia with isolated vitamin E deficiency
familial isolated vitamin E deficiency
familial isolated deficiency of vitamin E
A familial hypercholesterolemia that is characterized by very high levels of low-density lipoprotein (LDL) cholesterol (usually above 400 mg/dl) and increased risk of premature atherosclerotic cardiovascular disease, and has_material_basis_in autosomal recessive homozygous mutation in the low density lipoprotein receptor adaptor protein 1 gene (LDLRAP1) on chromosome 1p36.
ARH
ARH1
ARH2
FHCB1
FHCB2
autosomal recessive hypercholesterolemia 1
autosomal recessive hypercholesterolemia 2
familial autosomal recessive hypercholesterolemia
autosomal recessive hypercholesterolemia
An asphyxiating thoracic dystrophy that has_material_basis_in homozygous mutation in the NEK1 gene on chromosome 4q33.
Majewski syndrome
SRPS2A
SRTD6
polydactyly with neonatal chondrodystrophy, type II
short rib-polydactyly syndrome type IIA
short-rib thoracic dysplasia 6 with or without polydactyly
An osteogenesis imperfecta that is characterized by bone fragility and blue sclerae and has_material_basis_in dominantly inherited mutations in the COL1A1 gene on chromosome 17q21.33 or the COL1A2 gene on chromosome 7q21.3.
OI1
osteogenesis imperfecta type I
osteogenesis imperfecta type 1
A neuronal ceroid lipofuscinosis that is characterized by juvenile-onset of progressive dementia, seizures, and progressive visual failure and an ultrastructural pattern of lipopigment with a 'fingerprint' profile and has_material_basis_in homozygous or compound heterozygous mutation in the CLN3 gene on chromosome 16p11.
Batten disease
CLN3
juvenile neuronal ceroid lipofuscinosis
neuronal ceroid lipofuscinosis 3
A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal recessive fashion.
AR-PKD
autosomal recessive polycystic kidney disease
A lens disease characterized by abnormal stretching of the zonular fibers resulting in dislocation of the lens. This dislocation may be mild to severe and may progress with age.
IEL
familial ectopia lentis
isolated ectopia lentis
A schwannomatosis characterized by bilateral vestibular schwannomas or a combination of unilateral vestibular schwannomas, non-vestibular schwannomas, meningiomas, ependymomas, and specific eye abnormalities that has_material_basis_in heterozygous mutation in the NF2 gene on chromosome 22q12.2. Eye abnormalities include juvenile subcapsular or cortical cataract, epiretinal membrane in a person less than 40 years old, and retinal hamartoma. This disease has been revised by international consensus. It was previously referred to as neurofibromatosis 2.
ACN
BANF
NF2
NF2-related schwannomatosis
SWN3
SWNV
acoustic neurofibromatosis
bilateral acoustic neurinoma
bilateral acoustic neurofibromatosis
bilateral acoustic schwannomas
central neurofibromatosis
familial acoustic neuromas
neurofibromatosis 2
neurofibromatosis type II
schwannomatosis 3
vestibular schwannomatosis
A neurofibromatosis characterized by multiple cafe-au-lait macules, skin fold freckling, neurofibromas, optic gliomas, Lisch nodules or choroidal abnormalities in the eye, or a specific bone abnormality that has_material_basis_in the NF1 gene on chromosome 17q11.2. Bone abnormalities include a distinctive osseous lesion such as sphenoid dysplasia, anterolateral bowing of the tibia, or pseudarthrosis of a long bone.
NF1
Peripheral Neurofibromatosis
Recklinghausen's neurofibromatosis
neurofibromatosis type I
von Recklinghausen Disease
neurofibromatosis 1
An organic acidemia characterized by impaired lysine, hydroxylysine, and tryptophan metabolism, increased urinary excretion of glutaric acid, and accumulation of 3-hydroxyglutaric and glutaric acid, resulting in striatal injury and a severe dystonic dyskinetic movement disorder that has_material_basis_in homozygous or compound heterozygous mutation in the GCDH gene on chromosome 19p13.
GA1
glutaric academia type 1
glutaric aciduria 1
glutaric aciduria type I
glutaryl-coA dehydrogenase deficiency
glutaryl-coenzyme A dehydrogenase deficiency
glutaric acidemia I
A mucopolysaccharidosis III characterized by neurodegeneration, behavioral problems, mild skeletal changes, and shortened life span that has_material_basis_in homozygous or compound heterozygous mutation in NAGLU on chromosome 17q21.2.
MPS3B
MPSIIIB
Mucopoly-saccharidosis type 3B
Mucopolysaccharidosis type 3B
N-acetyl-alpha-glucosaminidase deficiency
NAGLU deficiency
Sanfilippo syndrome type B
mucopolysaccharidosis type IIIB (Sanfilippo B)
mucopolysaccharidosis type IIIB
A familial hyperlipidemia characterized by hypertriglyceridemia and fasting chylomicronemia.
familial chylomicronemia syndrome
A familial chylomicronemia syndrome characterized by onset in adolescence or adulthood of hypertriglyceridemia and fasting chylomicronemia that has_material_basis_in homozygous or compound heterozygous mutation in the APOC2 gene on chromosome 19q13.32.
C-II anapolipoproteinemia
familial APOC2 deficiency
familial apoC-II deficiency
hyperlipoproteinemia, type 1b
hyperlipoproteinemia, type Ib
familial apolipoprotein C-II deficiency
A primary immunodeficiency disease that involves multiple components of the immune system.
combined immunodeficiency
A non-syndromic X-linked intellectual disability characterized by moderate to severe intellectual disability in males and varying levels of intellectual disability in females that has_material_basis_in hemizygous or heterozygous mutation in the IQSEC2 gene on chromosome Xp11.22.
MRX1
MRX18
MRX78
X-linked mental retardation 1
X-linked mental retardation 1/78
X-linked mental retardation 18
X-linked mental retardation 78
non-syndromic X-linked intellectual disability 1
A spondylocostal dysostosis that has_material_basis_in homozygous or compound heterozygous mutation in the DLL3 gene on chromosome 19q13.2.
SCDO1
autosomal recessive spondylocostal dysostosis 1
spondylocostal dysostosis 1
A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities.
MEN type IIB
MEN2B
Multiple endocrine neoplasia, type 3
Wagenmann-FroboInOwlese syndrome
mucosal neuroma syndrome
multiple endocrine neoplasia type 2B
A multiple endocrine neoplasia that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas.
MEN type I
Wermer syndrome
Wermer's syndrome
multiple endocrine neoplasia type 1
A small intestine cancer that is located_in the beginning section of the small intestine.
Duodenal cancer
cancer of duodenum
duodenal neoplasm
duodenum cancer
An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction.
corneal disease
A gastrointestinal system cancer that is located_in the intestine.
malignant intestinal tumors
malignant neoplasm of intestine
intestinal cancer
A microcytic anemia characterized by decreased synthesis of one or more hemoglobin polypeptide chains.
Sickle-cell thalassemia with crisis
Sickle-cell thalassemia without crisis
thalassemia Hb-S disease with crisis
thalassemia Hb-S disease without crisis
thalassemia
A male reproductive organ cancer that is located_in the prostate.
NGP - new growth of prostate
hereditary prostate cancer
malignant tumor of the prostate
prostate cancer, familial
prostate neoplasm
prostatic cancer
prostatic neoplasm
tumor of the prostate
prostate cancer
A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
cancer of prostate
carcinoma of prostate
prostate carcinoma
A breast benign neoplasm that has_material_basis_in fibrous tissue and is characterized by the development of cystic spaces.
Diffuse cystic mastopathy
Fibrocystic disease of breast
breast Fibrocystic Change
breast fibrocystic disease
A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood.
lymphoblastic leukaemia
lymphoblastic leukemia
lymphocytic leukaemia
lymphoid leukemia
A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood.
B-cell chronic lymphocytic leukaemia
B-cell chronic lymphocytic leukemia
CLL
chronic lymphatic leukaemia
chronic lymphatic leukemia
chronic lymphocytic leukaemia
lymphoplasmacytic leukaemia
lymphoplasmacytic leukemia
B-cell chronic lymphoid leukemia
chronic lymphocytic leukemia
A physical disorder that is characterized by abnormal segmentation of the vertebra during fetal development which results in fusion located in cervical vertebra.
Klippel-Feil and Turner syndrome
Klippel-Feil deformity, deafness and facial asymmetry
autosomal dominant Klippel-Feil syndrome
congenital dystrophia brevicollis
congenital synostosis of cervical vertebrae
Klippel-Feil syndrome
A pterygium that is characterized by conjunctival degeneration, a fleshy outpouching of conjunctival growth and has_symptom fleshy bumps on the surface of the eye, foreign body sensation, decreased vision, and astigmatism. Conjunctival pterygiums are more common in people prone to ocular surface injury, such as those living in sunny, hot, and dry climates. Conjunctival pterygiums progress from pinguecula.
Web eye
conjunctival pterygium
A gastrointestinal system cancer that is located_in the stomach.
gastric cancer
gastric neoplasm
stomach cancer
Lymphoma of the stomach
gastric lymphoma
A syndrome that has_material_basis_in mutation in the OCRL gene on chromosome Xq26 and that is characterized by hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, amino aciduria, and reduced ammonia production by the kidney.
Lowe syndrome
lowe oculocerebrorenal syndrome
oculocerebrorenal syndrome of Lowe
oculocerebrorenal syndrome
A cerebral degeneration characterized by dysfunction of the white matter of the brain.
leukodystrophy
A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system.
MLD
Scholz cerebral sclerosis
arylsulfatase A deficiency
deficiency of cerebroside-sulfatase
sulfatide lipoidosis
metachromatic leukodystrophy
A lipid metabolic disorder that is characterized by a tetrad of clinical abnormalities: retinitis pigmentosa, peripheral neuropathy, cerebellar ataxia, and accumulation of an unusual branched-chain fatty acid, phytanic acid, in blood and tissues.
HMSN type IV
HSMN IV
Heredopathia atactica polyneuritiformis
Refsum's disease
adult Refsum disease
classic Refsum disease
phytanic acid oxidase deficiency
Refsum disease
A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss.
pericentral pigmentary retinopathy
retinitis pigmentosa
Diffuse globoInOwlid body sclerosis
GLOBOID CELL LEUKOENCEPHALOPATHY
Galactosylceramide beta-galactosidase deficiency
Krabbe's disease
Krabbe's leukodystrophy
beta galactocerebrosidase deficiency
globoInOwlid cell leukodystrophy
Krabbe disease
A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death.
ALD
Bronze Schilder disease
Encephalitis periaxialis concentrica
Encephalitis periaxialis, Schilder's
Siemerling-Creutzfeldt Disease
X-linked adrenoleukodystrophy
diffuse sclerosis
sudanophilic cerebral sclerosis
MESH:D000326w added from NeuroDevNet [WAK].
adrenoleukodystrophy
A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm.
CMT - Charcot-Marie-Tooth disease
Charcot-Marie-Tooth disease
An amino acid metabolic disorder that is caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.
Neutral 1 amino acid transport defect
deficiency of tryptophan oxygenase
neutral amino acid transport defect
Hartnup disease
A renal tubular transport disease of the proximal renal tubes characterized by glucosuria, phosphaturia, generalized aminoaciduria and HCO3 wasting.
Congenital Fanconi syndrome
De Toni-Fanconi syndrome
Fanconi-de Toni syndrome
Fanconi-de-Toni syndrome
Infantile nephropathic cystinosis
Lignac-Fanconi syndrome
adult Fanconi Anemia
adult Fanconi syndrome
deToni Fanconi syndrome
Fanconi syndrome
A syndrome that is characterized by diabetes mellitus, optic atrophy, and deafness.
WFS
Wolfram syndrome
A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and that has_material_basis_in mutations in the CTNS gene, located on chromosome 17.
cystine storage disease
cystinosis
A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Alzheimer disease
Alzheimers dementia
Alzheimer's disease
A duodenum cancer that derives_from epithelial cells of glandular origin.
Duodenal adenocarcinoma
duodenum adenocarcinoma
A mouth disease located_in the salivary gland.
Non-neoplastic Salivary gland disease
salivary gland disease
spinal dysraphism
tethered spinal cord syndrome
A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head.
hydrocephalus
A nutritional deficiency disease that is characterized by ophthalmoplegia, ataxia, change in mental status and acute onset of severe memory impairment without any dysfunction in intellectual abilities, and has_material_basis_in thiamine deficiency.
Korsakoff Syndrome
Korsakoff's psychosis
Korsakoff's syndrome
Korsakov psychosis
Korsakov's psychosis
Wernicke-Korsakoff syndrome
A sickle cell disease that is characterized by the replacement of both of the beta-globin subunits in hemoglobin with hemoglobin S, resulting in a low number of red blood cells, repeated infections, and periodic episodes of pain.
Hb SC disease
Hb-S/Hb-C disease
Hb-SS disease without crisis
HbSS disease
Hemoglobin S disease without crisis
Sickle-cell/Hb-C disease without crisis
drepanocytosis
haemoglobin SC disease
hemoglobin SC disease
homozygous sickle cell disease
sickle cell anaemia
sickle cell anemia
brain aneurysm
intracranial aneurysm
A thalassemia involving the genes HBA1and HBA2 hemoglobin genes.
Alpha thalassaemia
alpha-Thalassemia
alpha thalassemia
A female reproductive system disease that is located_in the ovary.
ovarian disease
An urinary system cancer that results_in malignant growth located_in the urinary bladder.
bladder cancer
tumor of the bladder
urinary bladder cancer
A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
cancer of esophagus
cancer of oesophagus
carcinoma of esophagus
carcinoma of oesophagus
esophageal carcinoma
A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.
Guinon's disease
Psychogenic tics
Tourette syndrome
motor-verbal tic disorder
Gilles de la Tourette syndrome
A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm.
connective and soft tissue neoplasm
tumor of soft tissue and skeleton
sarcoma
A syndrome that has_material_basis_in a large deletion of the chromosome 22q11.2 region which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production.
22q11.2 deletion syndrome
DiGeorge sequence
DiGeorge's syndrome
Pharyngeal pouch syndrome
DiGeorge syndrome
An anemia that is characterized by a low normal mean corpuscular volume (MCV) (less than 80 fL) and is defined by the presence of small, often hypochromic, red blood cells in a peripheral blood smear.
microcytic anemia
A cardiovascular system disease that involves the heart.
heart disease
A hereditary sensory and autonomic neuropathy characterized by progressive degeneration of sensory and autonomic neurons with congenital or neonatal onset resulting in impaired pain and temperature perception and profound dysautonomia that has_material_basis_in homozygous or compound heterozygous mutation in the ELP1 gene on chromosome 9q31. Common signs and symptoms include gastrointestinal dysfunction with vomiting crises, recurrent aspiration pneumonia, altered sensitivity to pain and temperature, extreme blood pressure variability with postural hypotension, hypotonia, decreased or absent deep tendon reflexes, decreased taste and absence of fungiform papillae of the tongue, alacrima, and early or sudden death.
HSAN III
HSAN3
Riley-Day syndrome
hereditary sensory and autonomic neuropathy type 3
hereditary sensory and autonomic neuropathy type III
familial dysautonomia
A lipid metabolism disease that is characterized by elevated levels of lipids in the blood.
familial hyperlipoproteinemia
hyperlipemia
hyperlipidaemia
familial hyperlipidemia
A diabetes mellitus that manifests during pregnancy.
GDM
Gestational diabetes mellitus
Maternal gestational diabetes mellitus
gestational diabetes
A glycogen storage disease that is characterized by exercise intolerance, muscle cramping, exertional myopathy, and compensated hemolysis and that has_material_basis_in homozygous or compound heterozygous mutation in the PFKM gene, which encodes muscle phosphofructokinase, on chromosome 12q13.
Glycogen storage disease 7
Glycogen storage disease, type VII
Muscle phosphofructokinase deficiency
glycogen storage disease type VII
phosphofructokinase myopathy
glycogen storage disease VII
A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_material_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region.
Dystrophia myotonica
Steinert disease
congenital myotonic dystrophy
myotonic dystrophy of Steinert
myotonic dystrophy type 1
A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.
Muscular dystrophy, Duchenne
Duchenne muscular dystrophy
A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles.
Erb's muscular dystrophy
Leyden-Mbius muscular dystrophy
limb girdle muscular dystrophy
limb-girdle muscular dystrophy
A syndrome that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features.
Brachmann de Lange syndrome
De Lange syndrome
Cornelia de Lange syndrome
A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle.
EDMD
Emery-Dreifuss muscular dystrophy
Landouzy Dejerine muscular dystrophy
Landouzy-Dejerine muscular dystrophy
Muscular dystrophy, Landouzy-Dejerine
facioscapulohumeral muscular dystrophy
A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.
nephrotic syndrome
A frontotemporal dementia that is characterized by a spectrum of neuropsychiatric symptoms ranging from those that affect the patient's personality to those that cause a decline in cognitive function.
Dementia in Pick's disease
LOBAR ATROPHY OF BRAIN
PICK DISEASE OF BRAIN
Pick disease
Pick's disease
A nervous system cancer that is located in the peripheral nervous system.
neoplasm of peripheral nerve
nerve sheath neoplasm
tumor of PNS
peripheral nervous system neoplasm
A dysostosis that results_in abnormal fusing of adjacent bones.
synostosis
A chromosomal disease that is characterized by weak muscle tone, feeding difficulties, poor growth, and delayed development. Beginning in childhood, affected individuals develop an insatiable appetite, which leads to chronic overeating and obesity.
Prader Willi syndrome
Prader-Willi syndrome
A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva.
female reproductive cancer
malignant Gynecologic tumor
malignant neoplasm of female genital organ
female reproductive organ cancer
A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability.
Rett's disorder
cerebroatrophic hyperammonemia
Rett syndrome
An agammaglobulinemia that is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells and that results in insufficient production of antibodies needed to respond to exposure of pathogens.
CVID
acquired agammaglobulinemia
acquired hypogammaglobulinemia
common variable agammaglobulinemia
sporadic hypogammaglobulinemia
common variable immunodeficiency
A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies.
Dementia with Lewy bodies
Diffuse Lewy body disease
Lewy body disease
Senile dementia of the Lewy body type
Lewy body dementia
A hemophilia that has_material_basis_in Factor IX deficiency, which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.
Congenital factor IX deficiency
Congenital factor IX disorder
deficiency, functional factor IX
factor IX deficiency
hemophilia B
An iris disease that is characterized by a complete or partial absence of the colored part of the eye.
Aplasia of iris
isolated aniridia
aniridia
Incontinentia pigmenti
Incontinentia pigmenti syndrome
Bloch-Sulzberger syndrome
An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.
vitiligo
An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue.
Lobstein's syndrome
Osteopsathyrosis
Vrolik's disease
brittle bone disease
Fragilitas ossium
osteogenesis imperfecta
A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.
leukemia
A normocytic anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.
aplastic anemia
A female reproductive organ cancer that is located_in the vulva.
Ca vulva
Vulvar tumor
malignant Vulvar tumor
malignant neoplasm of vulva
malignant tumor of vulva
neoplasm of vulva
vulval cancer
vulval neoplasm
vulvar neoplasm
vulva cancer
A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding.
coagulation protein disease
postpartum coagulation defect
postpartum coagulation defect with delivery
inherited blood coagulation disease
blood coagulation disease
A syndrome that has_material_basis_in deletion of the end of the chromosome 5 p arm and that is characterized by intellectual disability, delayed development, small head size, low birth weight, weak muscle tone widely set eyes, low-set ears, a small jaw, a rounded face and a high-pitched cry that sounds like that of a cat.
5p deletion syndrome
5p partial monosomy syndrome
chromosome 5 short arm deletion syndrome
chromosome 5p deletion syndrome
Cri-Du-Chat syndrome
A chromosomal deletion disease that has_material_basis_in da 1.5- to 3.0-Mb hemizygous deletion of chromosome 22q11.2 and that is characterized by variable developmental problems and schizoid features. Haploinsufficiency of the TBX1 gene in particular is responsible for most of the physical malformations.
Shprintzen syndrome
VCF-Velocardiofacial syndrome
velocardiofacial syndrome
A lymphoid leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity producing large numbers of white blood cells to be produced and enter the blood stream.
Stem cell Leukemia
Stem cell leukaemia
acute leukemia
A vascular disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins.
Osler hemorrhagic telangiectasia syndrome
Osler-Weber-Rendu disease
Rendu-Osler-Weber disease
hereditary hemorrhagic telangiectasia
An autosomal recessive cerebellar ataxia that is characterized by cerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancy and that has_material_basis_in homozygous or compound heterozygous mutation in the ATM gene on chromosome 11q22.
Boder-Sedgwick syndrome
Louis Bar syndrome
ataxia telangiectasia
Friedreich's ataxia
Friedreich's tabes
Friedreich ataxia
A syndrome characterized by short limbs, short ribs, postaxial polydactyly, dysplastic nails and teeth, and in many patients congenital cardiac defects that has_material_basis_in homozygous or compound heterozygous mutation in either the EVC or EVC2 gene on chromosome 4p16.2.
Chondroectodermal dysplasia
mesoectodermal dysplasia
Ellis-Van Creveld syndrome
A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine.
Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS].
mucopolysaccharidosis
A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme iduronate sulfatase.
Hunter syndrome
Hunter's syndrome
MPS II - Hunter syndrome
Mucopolysaccharidosis, MPS-II
deficiency of iduronate-2-sulphatase
OMIM mapping submitted by NeuroDevNet. [LS].
mucopolysaccharidosis II
A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase.
MPS VI - Maroteaux-Lamy syndrome
Maroteaux - Lamy syndrome
Maroteaux-Lamy syndrome
arylsulfatase B deficiency
deficiency of N-acetylgalactosamine-4-sulfatase
mucopolysaccharidosis VI
A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain.
Mucopolysaccharidosis, MPS-III
N-sulphoglucosamine sulphohydrolase deficiency
Sanfilippo's syndrome
heparan sulfate sulfatase deficiency
naglu deficiency
mucopolysaccharidosis III
A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme alpha-L-iduronidase.
Hurler syndrome
Hurler-Scheie syndrome
Lipochondrodystrophy
MPS I - Hurler syndrome
Mucopolysaccharidosis, MPS-I
Mucopolysaccharidosis, type 1
iduronidase deficiency disease
mucopolysaccharidosis I
A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme beta-glucuronidase resulting in the inability to degrade glucuronic acid-containing glycosaminoglycans.
MPS VII - Sly syndrome
Sly syndrome
beta-glucuronidase deficiency
deficiency of beta-glucuronidase
mucopolysaccharidosis VII
mucopolysaccharidosis type VII
A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain.
Mucopolysaccharidosis, MPS-IV
deficiency of N-acetylgalactosamine-6-sulphatase
deficiency of chondroitinsulphatase
galactosamine-6-sulfatase deficiency
Osteochondrodystrophy
chondroosteodystrophy
mucopolysaccharidosis IV
An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.
Kanner's syndrome
autism
autistic disorder of childhood onset
childhood autism
infantile autism
autistic disorder
A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.
Huntington disease
Huntington's chorea
Huntington's disease
A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
disease of subdivision of hemolymphoid system
cardiovascular system disease
A central nervous system disease that results in the progressive deterioration of function or structure of neurons.
degenerative disease
neurodegenerative disease
A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Vulvar carcinoma
carcinoma of vulva
vulva carcinoma
A congenital hemolytic anemia characterized by the production of red blood cells with a sphere shape, rather than the normal biconcave disk shape.
Congenital spherocytic hemolytic anemia
Minkowski Chauffard syndrome
spherocytic anemia
hereditary spherocytosis
A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.
dementia
A childhood spinal muscular atrophy that is a severe form and is characterized by muscle weakness onset from birth to six months of age, the inability to sit unassisted and that has_material_basis_in a mutation or deletion in the telomeric copy of the SMN gene, known as SMN1, on chromosome 5q13.
HMN (Hereditary motor Neuropathy) Proximal type I
SMA1
Spinal muscular atrophy 1
hereditary motor neuropathy proximal type I
infantile muscular atrophy
progressive muscular atrophy of infancy
Werdnig-Hoffmann disease
An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.
Articular gout
Gouty arthropathy
gouty arthritis
gout
A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain.
BT - Brain tumour
adult brain tumor
adult malignant brain neoplasm
brain neoplasm
brain neoplasm, adult
malignant brain tumour
malignant primary brain neoplasm
malignant primary brain tumor
malignant tumor of Brain
malignant tumor of adult brain
neoplasm of brain
primary brain neoplasm
primary brain tumor
primary malignant neoplasm of brain
tumor of the Brain
brain cancer
A respiratory system cancer that is located_in the lung.
lung neoplasm
lung cancer
An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins.
Hematoporphyria
Porphyrinopathy
disorder of porphyrin and hem metabolism
disorder of porphyrin metabolism
porphyria
Coproporphyrinogen oxidase deficiency
hereditary coproporphyria porphyria
hereditary coproporphyria
An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue.
EPP
Protoporphyria
erythropoietic protoporphyria
Erythropoietic porphyria
cutaneous porphyria
A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules.
Cutis hyperelastica
elastic skin
OMIM mapping confirmed by DO. [LS]. OMIM mapping by NeuroDevNet. [LS].
Ehlers-Danlos syndrome
A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.
Stone Man Syndrome
myositis ossificans progressiva
progressive myositis ossificans
progressive ossifying myositis
fibrodysplasia ossificans progressiva
An aplastic anemia that is characterized by insufficient production of red blood cells, usually seen in the first year of life.
congenital aplastic anaemia
congenital aplastic anemia
congenital hypoplastic anaemia
Constitutional aplastic anaemia
congenital hypoplastic anemia
An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.
thanatophoric dysplasia
A syndrome characterized by highly variable, progressive features including asymmetric and disproportionate overgrowth of body parts, connective tissue nevi, epidermal nevi, dysregulated adipose tissue, vascular malformations, dysmorphic facies with seizures or intellectual disability, and tumors that has_material_basis_in mosaicism for a somatic activating mutation in the AKT1 gene on chromosome 14q32.3. There is significant risk of deep vein thrombosis.
Wiedemann's syndrome
Proteus syndrome
A facial nerve disease characterized by congenital, uni- or bilateral, non-progressive facial weakness and limited abduction of the eye(s).
Mobius syndrome
Moebius congenital oculofacial paralysis
Oromandibular-limb hypogenesis spectrum
Moebius syndrome
A hamartoma syndrome that is characterized by the growth of numerous noncancerous tumors in many parts of the body.
Bourneville's disease
Epiloia
Tuberose sclerosis
Tuberous sclerosis complex
Tuberous sclerosis syndrome
cerebral sclerosis
tuberous sclerosis
An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.
Albers-Schonberg disease
marble bone
osteopetrosis
A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair.
Fanconi anaemia
Fanconi pancytopenia
Fanconi panmyelopathy
Fanconi's anaemia
Fanconi's anemia
Xref MGI. OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS].
Fanconi anemia
A primary immunodeficiency disease that is characterized by increased susceptibility to infection with specific human papillomavirus (HPV) genotypes, usually beta-HPV strains, and to the oncogenic potential of some of them, mainly HPV5 and HPV8. Affected individuals develop disseminated flat wart-like and pityriasis versicolor-like cutaneous lesions in childhood or adolescence. Associated with a high risk of carcinoma and has_symptom lesions on the body.
epidermodysplasia verruciformis
A uterine cancer that is located_in tissues lining the uterus.
endometrial Ca
endometrial neoplasm
malignant endometrial neoplasm
malignant neoplasm of endometrium
neoplasm of endometrium
primary malignant neoplasm of endometrium
tumor of Endometrium
endometrial cancer
familial multiple lipoprotein-type hyperlipidemia
hyperbetalipoproteinemia with prebetalipoproteinemia
mixed hyperlipidaemia
type IIb hyperlipoproteinemia
familial combined hyperlipidemia
A familial hyperlipidemia characterized by very high levels of low-density lipoprotein (LDL) and early cardiovascular disease.
Fredrickson type IIa hyperlipoproteinemia
Fredrickson type IIa lipidaemia
familial hyperbetalipoproteinaemia
familial hypercholesteremia
hyperbetalipoproteinemia
type II hyperlipidemia
familial hypercholesterolemia
A hypolipoproteinemia that is characterized by an inability to fully absorb dietary fats, cholesterol and fat-soluble vitamins, has_material_basis_in an autosomal recessive disorder of lipid metabolism that has_material_basis_in mutation in the microsomal triglyceride transfer protein that catalyzes the transport of lipids and is required in the secretion of BETA-LIPOPROTEINS.
familial hypobetalipoproteinemia
microsomal triglyceride transfer protein deficiency disease
abetalipoproteinemia
sinus node infection
sick sinus syndrome
A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance.
ACHM
Monochromatism
achromatopsia
An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in undeveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull.
Marie-Sainton Disease
cleidocranial dysostosis
cleidocranial dysplasia
A familial hyperlipemia characterized by a deficiency of the enzyme lipoprotein lipase and the subsequent build up of chylomicrons and increased plasma concentration of triglycerides.
Fredrickson type I hyperlipoproteinemia
Fredrickson type I lipaemia
familial LPL deficiency
familial hyperlipoproteinemia type I
hypercholesterinaemic xanthomatosis
hyperchylomicronemia
mixed hyperglyceridemia
familial lipoprotein lipase deficiency
Gyrate atrophy of the choroid and/or retina
Ornithinemia with gyrate atrophy
gyrate atrophy of the retina
OMIM mapping by NeuroDevNet. [LS].
gyrate atrophy
An uveal disease that is located_in the choroid.
choroid disease
Hippel Lindau syndrome
von Hippel-Lindau syndrome
von Hippel-Lindau disease
A syndrome characterized by disruption of mineralization of bones and teeth that has_material_basis_in mutation in the ALPL gene on chromosome 1p36.12.
deficiency of alkaline phosphatase
hypophosphatasia
A male infertility disease characterized by the absence of any measurable level of sperm in semen.
azoospermia
A chromosomal duplication syndrome that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability.
Complete trisomy 21 syndrome
Down's syndrome
Down's syndrome - trisomy 21
Downs syndrome
G Trisomy
trisomy 21 syndrome
Down syndrome
A RASopathy that is characterized by autosomal dominant inheritance of brown skin spots called lentigines that are similar to freckles, heart defects, widely spaced eyes a sunken chest or protruding chest and short stature.
Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome
Generalized lentiginosis
Gorlin syndrome II
LEOPARD syndrome
Lentiginosis profusa syndrome
Moynahan syndrome
Multiple lentigines syndrome
Progressive cardiomyopathic lentiginosis
Noonan syndrome with multiple lentigines
A connective tissue disease that is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens.
Marfan's syndrome
Marfan syndrome
A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
Parkinson disease
paralysis agitans
Parkinson's disease
An amino acid metabolic disorder that involves defective proteins called carnitine transporters, which bring carnitine into cells and prevent its escape from the body preventing the body cannot utilize fats for energy.
carnitine transporter deficiency
carnitine uptake defect
deficiency of plasma-membrane carnitine transporter
primary carnitine deficiency
renal carnitine transport defect
systemic primary carnitine deficiency disease
An autosomal dominant cerebellar ataxia that is characterized by slow degeneration of the hindbrain and has_material_basis_in expansion of CAG triplet repeats (glutamine) in the ATXN3 gene.
Azorean disease
MJD
SCA3
spinocerebellar ataxia 3
spinocerebellar ataxia type 3
Machado-Joseph disease
A cerebellar ataxia that has_material_basis_in autosomal dominant inheritance.
spinocerebellar ataxia
autosomal dominant cerebellar ataxia
A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue.
Brain degeneration
cerebral degeneration
A disorder of sexual development that is characterized by a progressive loss of germ cells on the developing gonads of an embryo.
Gonadal dysgenesis syndrome
gonadal dysgenesis
A gonadal dysgenesis that is characterized by a normal 46,XY karyotype along with a progressive loss of germ cells on the developing gonads of an embryo.
46 XY gonadal dysgenesis
46,XY sex reversal
Pure gonadal dysgenesis 46,XY
Swyer syndrome
The term 46,XY DSD has replaced the following terms Male pseudohermaphrodite, Undervirilization of an XY male, Undermasculinization of an XY male, Mixed gonadal dysgenesis, Partial gonadal dysgenesis. OMIM mapping confirmed by DO. [SN]. OMIM mapping confirmed by DO. [LS].
46,XY complete gonadal dysgenesis
A gonadal dysgenesis that is characterized by the lack of functional ovaries to induce puberty in an otherwise 46,XX female.
ovarian dysgenesis
46 XX gonadal dysgenesis
A lysosomal acid lipase deficiency characterized by infantile onset of rapidly progressive accumulation of cholesteryl esters and triglycerides throughout the body, resulting in hepatosplenomegaly, severe malnutrition, jaundice, vomiting, diarrhea, steatorrhea. Death usually occurs within the first year of life.
Acid esterase deficiency
Acid lipase deficiency
Wolman xanthomatosis
Wolman's disease
Wolman's or triglyceride storage type III disease
Xanthomatosis, familial
acute infantile lysosomal acid lipase deficiency
complete LAL deficiency
complete LIPA deficiency
complete cholesterol ester hydrolase deficiency
complete lysosomal acid lipase deficiency
Wolman disease
Lipid proteinosis
URBACH-WIETHE DISEASE
lipoid proteinosis
A sphingolipidosis that is characterized by the buildup of globotriaosylceramide in the body's cells and has_material_basis_in X-linked inherited mutations in the GLA gene, encoding alpha-galactosidase A, on chromosome Xq22.
Alpha-galactosidase A deficiency
Angiokeratoma Corporis Diffusum
Fabry Disease, Cardiac Variant
Fabry's disease
alpha galactosidase deficiency
deficiency of melibiase
Fabry disease
A-fucosidase deficiency
alpha fucosidase deficiency
fucosidosis
A syndrome that is characterized by ichthyosis, mental retardation, spastic paraparesis, macular dystrophy, and leukoencephalopathy, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the aldehyde dehydrogenase 3 family member A2 (ALDH3A2) gene, which encodes fatty aldehyde dehydrogenase, on chromosome 17p11.
FALDH deficiency
SLS
Sjogren Larsson syndrome
Sjogren-Larsson's syndrome
fatty acid alcohol oxidoreductase deficiency
Sjogren-Larsson syndrome
hereditary ceroid lipofuscinosis
neuronal ceroid lipofuscinosis
A sphingoliidosis characterized by the accumulation of the lipid sphingomyelin in lysosomes in cells.
Sphingomyelinase Deficiency Disease
lipoid histiocytosis
sphingomyelin lipidosis
Niemann-Pick disease
A disease that is characterized by abnormally rapid cell division.
cell process disease
neoplasm
disease of cellular proliferation
Rutledge lethal multiple congenital anomaly syndrome
Smith-Opitz-Inborn syndrome
Smith-Lemli-Opitz syndrome
A galactosemia that involves an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase.
Galactosemia II
galactokinase deficiency
An organic acidemia that involes a nonfunctional propionyl CoA carboxylase affecting conversion of amino acids and fats into sugar for energy.
GLYCINEMIA, KETOTIC
KETOTIC HYPERGLYCINEMIA
ketotic II glycinemia
ketotic glycinemia
propionic aciduria
propionyl-CoA carboxylase deficiency
propionic acidemia
A congenital structural myopathy characterized by abnormally located nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery.
myotubular myopathy
centronuclear myopathy
An Ehlers-Danlos syndrome that is characterized by loose-jointedness and fragile, bruisable skin that heals with peculiar 'cigarette-paper' scars and that has_material_basis_in heterozygous mutation in the collagen alpha-1(V) gene (COL5A1) on chromosome 9q34.
Ehlers-Danlos syndrome, type 1
type I Ehlers-Danlos syndrome
Ehlers-Danlos syndrome classic type 1
A syndrome that is characterized by prenatal and postnatal overgrowth, accelerated osseous maturation, characteristic craniofacial appearance, and developmental delay and has_material_basis_in heterozygous mutation in the EZH2 gene on chromosome 7q36.
WEAVER-LIKE SYNDROME
Weaver-Williams syndrome
Weaver syndrome
A syndrome that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life.
cerebral gigantism
Sotos syndrome
An organic acidemia that involves an accumulation of methylmalonic acid in the blood.
methylmalonic aciduria
methylmalonic acidemia
An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine.
Isovaleryl-CoA dehydrogenase deficiency
isovaleric acid CoA dehydrogenase deficiency
isovaleric aciduria
isovaleric acidemia
An amino acid metabolic disorder that involves the accumulation of argininosuccinic acid (ASA) in the blood and urine.
Argininosuccinate lyase deficiency
argininosuccinic acidemia
arginosuccinase deficiency
deficiency of argininosuccinate lyase
argininosuccinic aciduria
An Ehlers-Danlos syndrome that has_material_basis_in heterozygous mutation in the COL3A1 gene on chromosome 2q32 and that is characterized by the association of unexpected organ fragility (arterial/bowel/gravid uterine rupture) with inconstant physical features as thin, translucent skin, easy bruising and acrogeric traits.
Ehlers-Danlos syndrome type 4
Ehlers-Danlos syndrome type IV
autosomal dominant type IV Ehlers-Danlos syndrome
vascular type Ehlers-Danlos syndrome
An Ehlers-Danlos syndrome that is characterized by joint hyperextensibility without skeletal deformity.
Ehlers-Danlos syndrome, type 3
type III Ehlers-Danlos syndrome
Ehlers-Danlos syndrome hypermobility type
An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face.
polysyndactyly with peculiars skull shape
Greig cephalopolysyndactyly syndrome
A renal disease that is characterized by the failure of one or both kidneys to develop.
hereditary renal aplasia
hereditary urogenital adysplasia
renal adysplasia
renal aplasia
renal agenesis
An ectodermal dysplasia characterized by short-limbed short stature and fine, sparse hair that has_material_basis_in homozygous or compound heterozygous mutation in the RMRP gene on chromosome 9p13.3.
CHH
McKusick type metaphyseal chondrodysplasia
Metaphyseal chondrodysplasia, McKusick type
cartilage-hair hypoplasia
An Ehlers-Danlos syndrome that is characterized by blue sclerae, corneal rupture after minor trauma, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobility of the joints and has_material_basis_in homozygous mutation in the ZNF469 gene on chromosome 16q24.
type VIB Ehlers-Danlos syndrome
brittle cornea syndrome 1
An ectodermal dysplasia that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth).
hypohidrotic ectodermal dysplasia
A syndrome that is characterized by microcephaly, growth retardation and a characteristic facial appearance including but not limited to narrow or triangular shaped head, micrognathia, ptosis, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.
Dubowitz's syndrome
Dubowitz syndrome
A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs.
mucoviscidosis
cystic fibrosis
A disease of anatomical entity that is located_in reproductive system organs.
genital system disease
reproductive system disease
A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.
disease of mental health
A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Caecum carcinoma
Cecal cancer
carcinoma of cecum
cecum carcinoma
A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Colonic carcinoma
carcinoma of colon
colon carcinoma
A large intestine cancer that is located_in the cecum.
malignant neoplasm of caecum
malignant tumor of the cecum
cecum cancer
A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.
cognitive disease
Organic Mental disorder
cognitive disorder
A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm.
respiratory system disease
A blood platelet disease that is characterized by low a platelet count in the blood.
thrombocytopenia
A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages.
integumentary system disease
An organ system cancer that originates in the mammary gland.
breast tumor
malignant neoplasm of breast
malignant tumor of the breast
mammary cancer
mammary tumor
primary breast cancer
mammary neoplasm
breast cancer
A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
malignant neoplasm
malignant tumor
primary cancer
Updating out dated UMLS CUI.
cancer
A physical disorder that is characterized by problems with the heart's structure that are present at birth.
Congenital Heart Defects
Congenital anomaly of heart
Heart Malformation
congenital heart defect
heart defect
Heart-congenital defect
congenital heart disease
A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed.
ichthyoses
non-syndromic ichthyosis
ichthyosis
A disease of anatomical entity that occurs in the muscular and/or skeletal system.
musculoskeletal system disease
An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.
Endocrine tumor
endocrine neoplasm
malignant Endocrine tumor
malignant neoplasm of endocrine gland
malignant tumour of endocrine gland
neoplasm of endocrine gland
neoplasm of endocrine system
endocrine gland cancer
An ichthyosis that is characterized by a build-up of scales on the skin, typically on the back of the neck and trunk resulting from skin cells that do not properly separate from the outermost surface of the skin, and has_material_basis_in X-linked recessive mutation or deletion of the STS gene on chromosome Xp22.
X-linked ichthyosis with steryl-sulphatase deficiency
X-linked placental steryl-sulphatase deficiency
X-linked recessive ichthyosis
X-linked ichthyosis
A carcinoma that derives_from squamous epithelial cells.
SCC
epidermoid carcinoma
malignant squamous cell tumor
squamous carcinoma
squamous cell Epithelioma
squamous cell cancer
squamous cell carcinoma
A cardiovascular cancer that is located_in blood vessels.
Blood vessel tumor
Blood vessel tumors
Blood vessel tumour disorder
Haemangiomatous tumour
blood vessel neoplasm
leiomyosarcoma of the renal Vein
malignant great vessel tumor
malignant tumor of pulmonary Vein
malignant tumor of pulmonary artery
malignant vascular neoplasm
malignant vascular tumor
neoplasm of great vessel
pulmonary artery malignant neoplasm
pulmonary vein malignant neoplasm
renal vein leiomyosarcoma
vascular tissue neoplasm
vascular tumors
vascular cancer
An organ system cancer that located_in the heart and blood vessels.
Cardiovascular tumors
cardiovascular neoplasm
cardiovascular cancer
A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.
vascular tissue disease
vascular disease
An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage.
Thyroid gland neoplasm
malignant neoplasm of thyroid gland
malignant tumour of thyroid gland
neoplasm of thyroid gland
thyroid gland cancer
thyroid neoplasm
thyroid cancer
A cell type cancer that has_material_basis_in mesothelial tissue that develops from the thin layer of tissue that covers many of the internal organs. Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma.
Diffuse malignant Mesothelioma
advanced malignant mesothelioma
asbestos-related malignant mesothelioma
malignant tumor of Mesothelium
malignant mesothelioma
An endocrine gland cancer located_in the pancreas.
Ca body of pancreas
Ca head of pancreas
Ca tail of pancreas
malignant neoplasm of body of pancreas
malignant neoplasm of head of pancreas
malignant neoplasm of tail of pancreas
pancreas neoplasm
pancreatic neoplasm
pancreatic tumor
pancreatic cancer
A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.
Non-neoplastic urinary tract disease
urinary tract disease
urinary system disease
A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.
petit mal seizure
pyknolepsy
absence seizure
childhood absence epilepsy
A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.
epilepsy syndrome
epileptic syndrome
epilepsy
An epilepsy syndrome that is characterized by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain.
idiopathic generalized epilepsy
generalized epilepsy
COPPER TRANSPORT DISEASE
Menkes kinky-hair syndrome
steely hair syndrome
Menkes disease
A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.
CA - bone cancer
bone neoplasm
bone tumour
malignant bone neoplasm
malignant bone tumour
malignant neoplasm of bone
malignant osseous tumor
neoplasm of bone
osseous tumor
bone cancer
A cholestasis characterized by impairment of the bile flow caused by obstruction located_in liver.
neonatal intrahepatic cholestasis
intrahepatic cholestasis
A cherubism that has_material_basis_in heterozygous mutation in the SH3BP2 gene on chromosome 4p16.3.
cherubism 1
A cranial nerve disease that is located_in the optic nerve.
disorder of the second nerve
optic nerve disorder
optic neuropathy
optic nerve disease
A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.
Naevocarcinoma
malignant melanoma
melanoma
A purine-pyrimidine metabolic disorder characterized by mental retardation, spastic cerebral palsy, choreoathetosis, uric acid urinary stones, and self-destructive biting of fingers and lips that has_material_basis_in mutation in the HPRT1 gene on chromosome Xq26.
Complete hypoxanthine-guanine phosphoribosyltransferase deficiency
HG-PRT deficiency
HPRT1 deficiency
Hypoxanthine-guanine phosphoribosyltransferase deficiency
Hypoxanthine-guanine-phosphoribosyltransferase deficiency
Lesch - Nyhan syndrome
X-linked hyperuricemia
deficiency of IMP pyrophosphorylase
hypoxanthine guanine phosphoribosyltransferase deficiency
Lesch-Nyhan syndrome
A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver.
Gaucher disease
acid beta-glucosidase deficiency
glocucerebrosidase deficiency
glucosylceramide beta-glucosidase deficiency
kerasin thesaurismosis
Gaucher's disease
A lipid storage disease characterized by functional deficiencies in the enzymes needed for lysosomal degradation of sphingolipid substrates.
sphingolipidoses
sphingolipidosis
An aortic valve stenosis that is characterized by a narrowing of the section of the aorta just above the valve that connects the aorta to the heart.
Supra-valvular aortic stenosis
supravalvular aortic stenosis
An organ system cancer that is manifested in the reproductive organs.
Reproductive tumor
malignant reproductive system neoplasm
cancer of reproductive system
reproductive organ cancer
A syndrome that is characterized by delayed development, intellectual disability, severe speech impairment, and problems with movement and balance.
happy puppet syndrome
puppetlike syndrome
Angelman syndrome
A syndrome characterized by short stature, moderate to sever intellectual disability, distinctive facial features and broad thumbs and first toes.
Broad Thumb-Hallux syndrome
Rubinstein syndrome
proximal chromosome 16p13.3 deletion syndrome
Rubinstein-Taybi syndrome
A bone development disease that results in defective ossification of bone.
dysostosis
A syndrome that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, hypogonadism, and renal failure in some cases.
Bardet-Biedl syndrome
A rectum cancer that derives_from epithelial cells of glandular origin.
Rectal adenocarcinoma
rectum adenocarcinoma
A musculoskeletal system cancer that is located_in connective tissue.
Tumour of connective tissue
connective tissue neoplasm
mesenchymal tissue malignant neoplasm
neoplasm of connective tissues
connective tissue cancer
A female reproductive organ cancer that is located_in the placenta.
Placental tumors
malignant Placental tumor
malignant neoplasm of placenta
neoplasm of placenta
placental cancer
primary malignant neoplasm of placenta
placenta cancer
An exostosis that has_material_basis_in a mutation on the genes EXT1, EXT2 and EXT3 which results in multiple bony spurs throughout a child's growth.
Multiple congenital exostosis
Multiple exostosis syndromes
Osteochondromatosis syndrome
hereditary multiple exostoses 1
hereditary multiple exostoses 2
hereditary multiple exostoses 3
multiple ostechondromas
hereditary multiple exostoses
A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue.
Vulvar Epidermoid carcinoma
vulvar squamous cell carcinoma
squamous cell carcinoma of vulva
vulva squamous cell carcinoma
A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly.
B cell (antibody) deficiencies
Immunoglobulin heavy chain deficiency
immunoglobulin heavy chain deletion
B cell deficiency
A syndrome characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings.
Congenital ectodermal defect
Congenital ectodermal dysplasia
ectodermal dysplasia
An ovarian cancer that is derives_from ovarian surface epithelium.
Ovarian Surface epithelial-Stromal tumor
ovary epithelial cancer
A kidney cancer that affects the kidneys and typically occuring in children.
adult nephroblastoma
Wilms' tumor
nephroblastoma
A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye.
Ocular tumor
eye neoplasm
malignant eye neoplasm
neoplasm of eye
neoplasm of eye proper
ocular cancer
A colorectal cancer that is located_in the colon.
colon cancer
A blood coagulation disease that is characterized by easy bleeding, has_symptom epistaxis, bleeding of the gums, menorrhagia, and occasionally hemarthrosis, and has_material_basis_in autosomal recessive inheritance of mutation in the F7 gene, which encodes coagulation factor VII, an important factor in the clotting cascade.
deficiency, stable
factor VII deficiency
Hereditary hypoproaccelerinaemia
Labile factor deficiency
Proaccelerin deficiency
deficiency, labile
factor V deficiency
A blood coagulation disease characterized by autosomal recessive inheritance of mucosal bleeding, purpuric skin bleeding, epistaxis, and menorrhagia with prolonged bleeding times, enlarged platelets and absence of platelet aggregation in response to von Willebrand factor that has_material_basis_in mutation in the GP1BA gene, the GP1BB gene, or the GP9 gene which are subunits of the platelet membrane von Willebrand factor receptor complex, glycoprotein Ib.
Bernard - Soulier thrombopathy
Bernard Soulier syndrome
Giant platelet syndrome
Hemorrhagic dystrophic thrombocytopenia
Thrombopathy, Bernard-Soulier
Bernard-Soulier syndrome
A blood coagulation disease that is characterized by an abnormal increase or decrease in platelets or platelet dysfunction.
Thrombocytopathy
platelet disorder
blood platelet disease
A blood coagulation disease that is characterized by the partial or complete absence of factor X activity in the blood.
disease, Stuart-Prower
factor X deficiency
Dense body defect
Platelet dense granule deficiency
Platelet storage pool defect
platelet storage pool deficiency
An epilepsy syndrome that is characterized by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response.
localisation-related epilepsy
partial epilepsy
focal epilepsy
A thrombophilia that is characterized by bleeding symptoms due to low levels of circulating prothrombin, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding coagulation factor II, also known as prothrombin, on chromosome 11p11.
Congenital factor II deficiency
Hereditary factor II deficiency disease
hypoprothrombinemia
Factor II deficiency
prothrombin deficiency
A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality.
syndrome
A bone development disease that results_in defective development of cartilage or bone.
Cartilage Development disorder
Congenital anomaly of cartilage
Osteochondrodysplasia syndrome
chondrodystrophy
skeletal dysplasia
osteochondrodysplasia
An endocrine system disease that is located_in the gonads.
gonadal disease
A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.
female reproductive system disease
A neurodegenerative disease that is located_in the motor neurons.
motor neuron disease
A craniosynostosis that involves premature fusion of certain skull bones. This early fusion prevents the skull from growing normally and affects the shape of the head and face. The disease is associated with mutations in the FGFR2 gene.
Craniofacial Dysostosis
Crouzon's disease
Crouzon syndrome
A colon carcinoma that derives_from epithelial cells of glandular origin.
Colonic adenocarcinoma
adenocarcinoma of colon
adenocarcinoma of the colon
colon adenocarcinoma
A metal metabolism disorder characterized by the accumulation of iron in various organs of the body.
Haemochromatosis
diabetes bronze
iron storage disorder
hemochromatosis
A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.
anaemia
PRISM.
anemia
neuroaxonal dystrophy
A sphingolipidosis that is characterized by the accumulation of lipids known as gangliosides.
gangliosidosis
A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Generalized multiple sclerosis
insular sclerosis
multiple sclerosis
A female reproductive organ cancer that is located_in the ovary.
malignant Ovarian tumor
malignant tumour of ovary
ovarian neoplasm
ovary neoplasm
primary ovarian cancer
tumor of the Ovary
ovarian cancer
A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.
Glomus neoplasm
Glomus tumour
glomus tumor
congenital neurologic anomaly
congenital nervous system abnormality
A syndrome characterized by multiple early-onset basal cell carcinoma, multiple jaw keratocysts and skeletal abnormalities.
Gorlin syndrome
NBCCS
basal cell nevus syndrome
nevoid basal cell carcinoma syndrome
A skin carcinoma affecting basal cells.
Basal cell cancer
Basal cell carcinoma of skin
Basal cell neoplasm
Basal cell tumor
Epithelioma basal cell
Rodent ulcer
malignant Basal cell neoplasm
malignant basal cell tumor
basal cell carcinoma
disorder of testis
testis disorder
testicular disease
A prostate carcinoma that derives_from epithelial cells of glandular origin.
prostate adenocarcinoma
An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.
Hematologic malignancy
Hematologic neoplasm
Hematological tumors
blood cancer
hematopoietic and lymphoid system tumor
hematopoietic cancer
hematopoietic neoplasm
hematopoietic tumors
malignant hematopoietic neoplasm
hematologic cancer
A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterized by increased number of normal or abnormal vessels filled with blood.
hemangioma
A corneal dystrophy that is characterized by corneal haze, bilateral loss of vision, eventually necessitating corneal transplantation resulting from progressive punctate opacities in the cornea.
Fehr corneal dystrophy
MACULAR DYSTROPHY, CORNEAL, 1
macular corneal dystrophy
A histiocytosis that is characterized by clonal proliferation of Langerhans cells.
Histiocytosis X
Langerhan's cell histiocytosis
Langerhans cell granulomatosis
Letterer-Siwe disease
Letterer-Siwe disease involving intra-abdominal lymph nodes
Letterer-Siwe disease involving intrapelvic lymph nodes
Letterer-Siwe disease involving intrathoracic lymph nodes
Letterer-Siwe disease involving lymph nodes of axilla and upper limb
Letterer-Siwe disease involving lymph nodes of head, face and neck
Letterer-Siwe disease involving lymph nodes of head, face, and neck
Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb
Letterer-Siwe disease involving lymph nodes of multiple sites
Letterer-Siwe disease involving spleen
Letterer-Siwe disease of intra-abdominal lymph nodes
Letterer-Siwe disease of intrapelvic lymph nodes
Letterer-Siwe disease of intrathoracic lymph nodes
Letterer-Siwe disease of lymph nodes of axilla and upper limb
Letterer-Siwe disease of lymph nodes of axilla and/or upper limb
Letterer-Siwe disease of lymph nodes of head, face and neck
Letterer-Siwe disease of lymph nodes of head, face and/or neck
Letterer-Siwe disease of lymph nodes of inguinal region amd/or lower limb
Letterer-Siwe disease of lymph nodes of inguinal region and lower limb
Letterer-Siwe disease of lymph nodes of inguinal region and/or lower limb
Letterer-Siwe disease of lymph nodes of multiple sites
Letterer-Siwe disease of spleen
Langerhans-cell histiocytosis
A chondrodysplasia punctata that is characterized by disproportionately short stature primarily affecting the proximal parts of the extremities, a typical facial appearance including a broad nasal bridge, epicanthus, high-arched palate, dysplastic external ears, and micrognathia, congenital contractures, characteristic ocular involvement, dwarfism, and severe mental retardation with spasticity.
Chondrodysplasia Punctata, Rhizomelic Form
rhizomelic chondrodysplasia punctata
A syndrome that is characterized by abnormal calcification of the epiphyses, causing stippling in radiography.
Chondrodysplasia punctata congenita
DeObs MGI.
chondrodysplasia punctata
A B cell deficiency that is caused by a reduction in all types of gamma globulins.
IGHM
hypogammaglobulinemia
mu heavy chain deficiency
agammaglobulinemia
A urinary system cancer that is located_in the kidney.
malignant neoplasm of kidney except pelvis
malignant tumour of kidney
renal cancer
kidney cancer
A carcinoma that derives_from transitional epithelial cells.
transitional carcinoma
transitional cell tumor
urothelial cell carcinoma
transitional cell neoplasm
transitional cell carcinoma
A syndrome characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability.
Bloom-Torre-Machacek syndrome
Congenital Telangiectatic Erythema syndrome
Bloom syndrome
A skin disease characterized by cutaneous pigmentation, premature graying, dystrophy of the nails, leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts, often thrombocytopenia, anemia, testicular atrophy in the male carriers and predisposition to cancer.
DKCD
Xref MGI. OMIM mapping by NeuroDevNet. [LS].
dyskeratosis congenita
A vesiculobullous skin disease that is characterized by formation of blisters with only minor skin trauma, which can cause widespread wounds, dehydration, electrolyte abnormalities, and severe infection, frequently develops_from mutations in connective tissue elements, including genes encoding keratin, collagen, and laminin.
acantholysis bullosa
epidermolysis bullosa
A skin disease characterized by poikiloderma, congenital bone defects, and an increased risk of osteosarcoma in childhood and skin cancer later in life that has_material_basis_in homozygous or compound heterozygous mutation in the DNA helicase gene RECQL4 on chromosome 8q24.
Congenital poikiloderma
RTS
Rothmund-Thomson syndrome
A connective tissue disease that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system.
Gronblad-Strandberg syndrome
pseudoxanthoma elasticum
A glycogen storage disease that is characterized by onset of exercise intolerance and muscle cramps in childhood or adolescence and that has_material_basis_in homozygous or compound heterozygous mutation in the PYGM gene, which encodes muscle glycogen phosphorylase, on chromosome 11q13.
Glycogen storage disease 5
Glycogen storage disease, type V
McArdle's disease
glycogen storage disease type V
myophosphorylase deficiency
glycogen storage disease V
A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.
glycogenosis
glycogenoses
glycogen storage disease
A glycogen storage disease that is characterized by an accumulation of abnormal glycogen with short outer chains and that has_material_basis_in homozygous or compound heterozygous mutation in the AGL gene, which encodes the glycogen debrancher enzyme, on chromosome 1p21.
Glycogen storage disease 3
Glycogen storage disease, type III
amylo 1,6 glucosidase deficiency
deficiency of debranching enzyme
deficiency of dextrin
glycogen storage disease IIIa
glycogen storage disease IIIb
glycogen storage disease III
A glycogen storage disease I that has_material_basis_in homozygous or compound heterozygous mutation in the G6PC gene, which encodes glucose-6-phosphatase (G6Pase), on chromosome 17q21.
glycogen storage disease Ia
A glycogen storage disease that has_material_basis_in homozygous or compound heterozygous mutation in the GBE1 gene, which encodes the glycogen branching enzyme, on chromosome 3p12.
Amylopectinosis
Branching-transferase deficiency glycogenosis
Glycogen storage disease 4
Glycogen storage disease, type IV
brancher deficiency glycogenosis
deficiency of 1,4-alpha-glucan branching enzyme
glycogen storage disease IV
A glycogen storage disease that is characterized hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase and results from the lack of expression of phosphorylase-b-kinase activity.
Glycogen storage disease 8
glycogen storage disease type VIII
glycogenosis type VIII
hepatic glycogen phosphorylase kinase deficiency
glycogen storage disease VIII
A glycogen storage disease characterized by cardiomyopathy and muscular hypotonia are the cardinal features.
Generalized glycogenosis
Glycogen storage disease 2
Glycogen storage disease, type II
Glycogenosis, type 2
Lysosomal alpha-1,4-glucosidase deficiency
Pompe disease
Pompe's disease
acid maltase deficiency
deficiency of glucoamylase
deficiency of maltase
glycogen storage disease type II
glycogen storage disease II
A glycogen storage disease characterized by enlargement of the liver, moderately low blood sugar, elevated levels of acetone and other ketone bodies in the blood and moderate growth retardation.
Glycogen storage disease 6
Hers' disease
glycogen storage disease type VI
hepatic glycogen phosphorylase deficiency
hepatophosphorylase deficiency glycogenosis
glycogen storage disease VI
A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome.
cerebellar disease
A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.
endocrine system disease
A chronic lymphocytic leukemia that is characterized by over production of B cells (lymphocytes) by the bone marrow where the B cells appear hairy under a microscope.
hairy cell leukemia
A endometrial cancer that is located_in the tissue lining the uterus.
carcinoma of the Endometrium
endometrioid carcinoma
endometrioid carcinoma of female Reproductive system
endometrial carcinoma
A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
cancer of cervix
carcinoma cervix uteri
carcinoma of cervix
carcinoma of the Cervix Uteri
cervix carcinoma
A disease of anatomical entity that is located_in the immune system.
immune system disease
A syndrome characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy and that has_material_basis_in homozygous or compound heterozygous mutation in the lysosomal trafficking regulator gene (LYST) on chromosome 1q42.
CHS
Chediak - Steinbrinck anomaly
Chediak-Higashi syndrome
A trichothiodystrophy characterized by skin that is extremely sensitive to ultraviolet (UV) rays from sunlight.
IBIDS syndrome
TTD-P
Tay syndrome
sulfur-deficient brittle hair syndrome
trichothiodystrophy with congenital ichthyosis
photosensitive trichothiodystrophy
A syndrome that is characterized by an abnormally small head size (microcephaly), a failure to gain weight and grow at the expected rate (failure to thrive) leading to very short stature, and delayed development.
Neill-Dingwall syndrome
Cockayne's syndrome
Cockayne syndrome
An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates.
disorder of carbohydrate transport and metabolism
inborn carbohydrate metabolism disorder
inborn errors of carbohydrate metabolism
carbohydrate metabolic disorder
An autoinflammatory disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has_material_basis_in mutations in the MEFV gene, which encodes the protein pyrin.
FMF
benign paroxysmal peritonitis
familial Mediterranean fever
A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.
adenocarcinoma
A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells.
malignant tumor of the germ cell
germ cell neoplasm
germ cell tumour
germ cell cancer
A male reproductive system cancer that is located_in the testicles.
childhood neoplasm of the testis
neoplasm of testis
pediatric testicular neoplasm
testicular tumor
testis cancer
testis neoplasm
testicular cancer
A breast carcinoma that derives_from the lining of milk ducts.
duct carcinoma
breast ductal carcinoma
A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated.
Infiltrating ductal carcinoma of breast
Invasive ductal carcinoma, NST
ductal adenocarcinoma
invasive ductal carcinoma
A cecum carcinoma that derives_from epithelial cells of glandular origin.
Cecal adenocarcinoma
cecum adenocarcinoma
A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
epithelial cancer
epithelioma
malignant Epithelioma
carcinoma
A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.
GBM
adult glioblastoma multiforme
glioblastoma multiforme
grade IV adult Astrocytic tumor
primary glioblastoma multiforme
spongioblastoma multiforme
glioblastoma
A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord.
Astrocytic tumor
astrocytoma of Cerebrum
astrocytoma of brain
astroglioma
cerebral astrocytoma
malignant astrocytoma
A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.
Neuroglial tumor
glial cell tumor
glioma, malignant
malignant Neuroglial tumor
malignant glioma
high grade glioma
An organ system cancer located_in the nervous system that affects the central or peripheral nervous system.
malignant neoplasm of nervous system
neoplasm of nervous system
nervous system neoplasm
neural neoplasm
neural tumor
tumor of the nervous system
nervous system cancer
A germ cell cancer that is derives_from a mixture of germs cells and embryonal cells.
germ cell and embryonal neoplasm
germ cell and embryonal cancer
A sarcoma characterized by the presence of small round or elongated malignant cells with a small amount of cytoplasm.
small cell sarcoma
Fukuhara syndrome
Myoclonic epilepsy - ragged red fibers
Myoclonus epilepsy AND ragged red fibers
Myoclonus with epilepsy and with Ragged Red Fibers
MERRF syndrome
renal and ureteral tumor
kidney benign neoplasm
A gastrointestinal system disease that is located_in the liver and/or biliary tract.
liver and biliary tract disease
hepatobiliary disease
An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.
GI tumor
digestive system cancer
gastrointestinal tract cancer
gastrointestinal system cancer
A biliary tract cancer that is located_in the gallbladder.
gallbladder Ca
gallbladder neoplasm
localized malignant gallbladder neoplasm
malignant neoplasm of gallbladder
malignant tumor of the gallbladder
malignant tumour of gallbladder
tumor of the gallbladder
gallbladder cancer
A syndrome that is characterized by tumors in at least two endocrine glands.
Multiple endocrine adenomatosis
Multiple endocrine neoplasia syndrome
multiple endocrine neoplasia
A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis.
hepatic porphyria
acute porphyria
A skin disease characterized by loose, hanging, wrinkled skin lacking in elasticity.
loose skin
cutis laxa
A familial hyperlipidemia that has_material_basis_in by homozygous, compound heterozygous, or heterozygous mutation in the APOE gene on chromosome 19q13.
Remnant hyperlipidemia
carbohydrate induced hyperlipemia
familial hypercholesterolaemia with hyperlipaemia
familial type 3 hyperlipoproteinemia
hyperlipoproteinemia type III
An inherited metabolic disorder that involves the creation and degradation of lipids.
dyslipidemia
fatty acid metabolism disorder
lipid metabolism disorder
A skin carcinoma that has_material_basis_in squamous cells.
Cutaneous Squamous Cell Carcinoma
Epidermoid skin carcinoma
squamous cell carcinoma of skin
skin squamous cell carcinoma
oligodendroglial neoplasm
oligodendroglial tumor
oligodendroglioma
A congenital myopathy characterized by generally non-progressive muscle weakness of varying severity and problems with the tone and contraction of skeletal muscles. The muscle cells contain abnormal clumps of threadlike material called nemaline bodies.
Nemaline body disease
nemaline rod myopathy
rod body disease
rod myopathy
nemaline myopathy
A RASopathy characterized by the development of schwannomas or hybrid nerve sheath tumors.
SWN
neurilemmomatosis
neurinomatosis
schwannomatosis
A hypomyelinating leukodystrophy characterized by impaired myelin formation, nystagmus, spastic quadriplegia, ataxia, and developmental delay that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22.
HLD1
Leukodystrophy, sudanophilic
PMD
Pelizaeus Merzbacher brain sclerosis
Pelizaeus-Merzbacher brain sclerosis
diffuse familial brain sclerosis
hypomyelinating leukodystrophy 1
sudanophilic leukodystrophy, Paelizeus-Merzbacher type
Pelizaeus-Merzbacher disease
An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.
disorder of lysosomal enzyme
inborn lysosomal enzyme disorder
lysosomal storage metabolism disorder
lysosomal storage disease
A skeletal muscle cancer that arise from skeletal muscle progenitors.
rhabdomyosarcoma
An integumentary system disease characterized by congenital absence of melanocytes in areas of the skin and hair that has_material_basis_in heterozygous mutation in the KIT gene on chromosome 4q12.
PIEBALD TRAIT
Partial albinism
This disease previously was thought to also have material basis in the SNAI2 gene but that gene likely does not contribute to this disease (see PMID:32975012).
piebaldism
An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes.
primary extragonadal embryonal carcinoma
embryonal carcinoma
A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.
central nervous system disease
malignant perivascular cancer
perivascular tumor
A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
ALS
Lou Gehrig's disease
motor neuron disease, bulbar
amyotrophic lateral sclerosis
A GM2 gangliosidosis that is characterized onset in infancy of developmental retardation, followed by paralysis, dementia and blindness, with death in the second or third year of life and has_material_basis_in homozygous or compound heterozygous mutation in the alpha subunit of the hexosaminidase A gene (HEXA) on chromosome 15q23.
GM2 gangliosidosis, type 1
hexosaminidase A deficiency
Tay-Sachs disease
A gangliosidosis that is characterized by excessive accumulation of ganglioside GM2 and related glycolipids in the lysosomes.
gangliosidosis GM2
GM2 gangliosidosis
A gangliosidosis that is characterized by progressive destruction of nerve cells in the brain and spinal cord and that has_material_basis_in mutations in the gene encoding beta-galactosidase-1 (GLB1) resulting in build up of GM1 ganglioside.
Beta-galactosidase deficiency
deficiency of beta-galactosidase
gangliosidosis GM1
GM1 gangliosidosis
A GM2 gangliosidosis that is characterized by an accumulation of GM2 gangliosides, particularly in neurons, and that has_material_basis_in mutation in the beta subunit of hexosaminidase (HEXB) on chromosome 5q13.
Sandhoff Jatzkewitz disease
Sandhoff disease
A mucolipidosis that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase).
Mucolipidosis type I
sialidosis
glycoproteinosis
A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus).
Osteogenic sarcoma
Skeletal sarcoma
bone tissue neoplasm
osteoid sarcoma
osteosarcoma
A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.
Fibrocytic tumor
fibrosarcoma of soft tissue
fibrous tissue neoplasm
fibrosarcoma
A peripheral primitive neuroectodermal tumor that is located_in bone.
Ewing's sarcoma/bone peripheral primitive neuroectodermal tumor
bone Ewing sarcoma
bone localized Ewing sarcoma
bone localized Ewing's sarcoma
localized Skeletal Ewing's sarcoma
Ewing's sarcoma of bone
bone Ewing's sarcoma
Ewing sarcoma of bone
A connective tissue cancer that has_material_basis_in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.
Ewing's family localized tumor
Ewing's sarcoma/peripheral primitive neuroectodermal tumor
Ewing's tumor
Ewings sarcoma
Ewings sarcoma-primitive neuroectodermal tumor
PNET of Thoracopulmonary Region
localized Ewing sarcoma
localized Ewing's sarcoma
localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor
localized Ewing's tumor
localized peripheral primitive neuroectodermal tumor
peripheral primitive neuroectodermal tumor
Ewing sarcoma
A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.
Cartilaginous cancer
chondrosarcoma of bone
primary chondrosarcoma of the bone
chondrosarcoma
A connective tissue cancer that arises in fat cells in deep soft tissue retroperitoneum and the extremities.
lipomatous cancer
liposarcoma
A lymphatic system disease that is characterized by an excessive number of histiocytes.
Hand Schuller Christian disease
chronic Histiocytosis X
histiocytosis
A lysosomal storage disease that has_material_basis_in deficiency of the alpha-D-manosidase enzyme resulting in the impairment of cell function from a build up of complex sugars derived from glycoproteins in the lysosome.
Alpha-D-mannosidosis
alpha-mannosidase deficiency
deficiency of alpha-mannosidase
alpha-mannosidosis
A female reproductive system disease that is located_in the uterus.
uterine disease
A skin cancer that is located_in tissues of the skin and develops from epithelial cells.
carcinoma of skin
skin carcinoma
A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.
Mammary adenocarcinoma
adenocarcinoma of breast
breast adenocarcinoma
A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Mammary carcinoma
carcinoma of breast
breast carcinoma
A disease of anatomical entity that is located_in the breast.
breast disease
An eye disease affecting the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid.
uveal disease
adult fibrosarcoma
cerebral arterial disease
A congenital myopathy that is characterized by muscle weakness primarily affecting the proximal muscles of the lower limbs beginning in infancy or early childhood, although later onset of symptoms has been reported and that has_material_basis_in heterozygous mutation in the ryanodine receptor-1 gene (RYR1) on chromosome 19q13. Heterozygous mutation in the RYR1 gene also causes susceptibility to malignant hyperthermia-1 (MHS1), patients with CMYP1A are at risk for MHS. Biallelic mutations in the RYR1 gene cause autosomal recessive CMYP1B, which shows overlapping features, but is typically more severe.
autosomal dominant congenital myopathy 1A
central core disease
central core myopathy
congenital myopathy 1A
A progressive myoclonus epilepsy characterized by myoclonus and/or generalized seizures, visual hallucinations, and progressive neurological decline with onset between 8 and 18 years of age that has_material_basis_in homozygous or compound heterozygous mutation in either NHLRC1 on chromosome 6p22.3 or EPM2A on chromosome 6q24.3.
Lafora Progressive Myoclonic Epilepsy
Lafora's disease
MYOCLONIC EPILEPSY OF LAFORA
progressive myoclonic epilepsy 2
Lafora disease
A hepatobiliary system cancer that is located_in the liver.
Ca liver - primary
Resectable malignant neoplasm of Liver
hepatic cancer
hepatic neoplasm
malignant hepato-biliary neoplasm
malignant neoplasm of liver
malignant neoplasm of liver, not specified as primary or secondary
malignant neoplasm of liver, primary
malignant tumor of liver
neoplasm of liver
non-resectable primary hepatic malignant neoplasm
primary liver cancer
primary malignant neoplasm of liver
resectable malignant neoplasm of the liver
liver cancer
gestational trophoblastic neoplasia
hydatidiform mole
molar pregnancy
gestational trophoblastic neoplasm
A placenta cancer that has_material_basis_in trophoblastic cells.
Chorioepithelioma
choriocarcinoma
A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells.
Pseudomucinous cystadenocarcinoma
mucinous cystadenocarcinoma
A leukodystrophy characterized by onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average that has_material_basis_in homozygous or compound heterozygous mutation in ASPA gene encoding aspartoacylase on chromosome 17p13.
ACY2 DEFICIENCY
AMINOACYLASE 2 DEFICIENCY
ASP DEFICIENCY
ASPA DEFICIENCY
ASPARTOACYLASE DEFICIENCY
CANAVAN-VAN BOGAERT-BERTRAND DISEASE
Spongy degeneration of central nervous system
Canavan disease
A nervous system cancer that is located_in the central nervous system.
CNS neoplasm
central nervous system tumor
central nervous system tumors
malignant neoplasm of central nervous system
malignant tumor of CNS
neoplasm of central nervous system
central nervous system cancer
A female reproductive organ cancer that is located_in the uterus.
CA - cancer of uterus
Tumour of uterus
malignant neoplasm of uterus
malignant uterine tumor
neoplasm of uterus
uterine tumor
uterus neoplasm
uterine cancer
A urinary system disease that is located_in the bladder.
Urinary Bladder Disease
bladder disease
A metabolic acidosis characterized by buildup of lactate.
lactic acidosis
A carbohydrate metabolic disorder that is characterized by deficiency of pyruvate carboxylase causing decreased utilization of carbohydrates and toxic accumulation of lactic acid, possibly has_symptom periodic lactate elevations, gastrointestinal upset, neonatal onset of metabolic acidosis, failure to thrive, developmental delay, seizures, death, and has_material_basis_in autosomal recessive inheritance of mutation in the PC gene, which encodes pyruvate carboxylase, a critical protein in the citric acid cycle and in gluconeogenesis.
deficiency of pyruvic carboxylase
pyruvate carboxylase deficiency disease
A cytochrome-c oxidase deficiency disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.
Infantile necrotizing encephalomyelopathy
Leigh syndrome
juvenile subacute necrotizing encephalomyelopathy
subacute necrotizing encephalomyelopathy
Leigh disease
A lysosomal storage disease characterized by increased sialic acid in the urine.
OMIM mapping confirmed by DO. [LS]. OMIM mapping submitted by NeuroDevNet. [LS].
sialuria
A hematologic cancer that has_material_basis_in mast cells.
Mast cell Proliferative disease
mast cell tumor
mastocytoma
mast cell neoplasm
An integumentary system disease that is located_in skin.
Genodermatosis
skin and subcutaneous tissue disease
skin disease
A cervix carcinoma that derives_from epithelial cells of glandular origin.
adenocarcinoma cervix uteri
adenocarcinoma of cervix
adenocarcinoma of the uterine Cervix
cervical adenocarcinoma
An ovarian carcinoma that derives_from epithelial cells of glandular origin.
Ovarian adenocarcinoma
ovarian adenoacanthoma
adenocarcinoma of the ovary
ovary adenocarcinoma
A stomach carcinoma that derives_from epithelial cells of glandular origin.
adenocarcinoma of stomach
stomach adenocarcinoma
gastric adenocarcinoma
Myeloma - solitary
Myeloma, solitary
Solitary myeloma
Solitary plasmacytoma
plasmacytoma
An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods.
Nutritional disorder
nutrition disease
A carcinoma of bladder that is manifested in squamous cells of the bladder.
Epidermoid carcinoma of the urinary bladder
squamous cell carcinoma of bladder
bladder squamous cell carcinoma
A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
squamous cell carcinoma of cervix
squamous cell carcinoma of the Cervix Uteri
cervical squamous cell carcinoma
An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.
SCC of esophagus
SCC of oesophagus
oesophagus squamous cell carcinoma
esophagus squamous cell carcinoma
A syndrome that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene).
Denys-Drash syndrome
A syndrome that is characterized by skeletal malformations, growth retardation, hearing deficit, paroxysmal movement disorders, and cognitive impairment in affected males and some carrier females, and has_material_basis_in mutation in the RSK2 gene on chromosome Xp22.
Coffin-Lowry syndrome
A bilirubin metabolic disorder that involves a build up of bilirubin as bilirubin is not being broken down as a result of a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT).
Bilirubin UDP glucuronyl transferase deficiency
Crigler Najjar syndrome
Crigler-Najjar syndrome, type I
Crigler-Najjar syndrome
A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.
male genital cancer
male reproductive system neoplasm
malignant neoplasm of male genital organ
malignant neoplasm of male genital organ or tract
malignant neoplasm of male genital organs
malignant tumor of male Reproductive system
malignant tumor of male genital organ
neoplasm of male genital organ
tumor of male Reproductive system
male genital neoplasm
male reproductive organ cancer
AIP - acute intermittent porphyria
Pyrroloporphyria
porphyria intermittent acute
acute intermittent porphyria
A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.
cancer of lung
carcinoma of lung
lung carcinoma
A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Epidermoid cell carcinoma of the lung
squamous cell carcinoma of lung
lung squamous cell carcinoma
A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.
NSCLC
Non-small cell lung cancer
non-small cell lung carcinoma
lung non-small cell carcinoma
A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.
bronchogenic lung adenocarcinoma
nonsmall cell adenocarcinoma
adenocarcinoma of lung
lung adenocarcinoma
A progeroid syndrome characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble aged persons that has_material_basis_in mutation in the LMNA gene on chromosome 1q22.
HGPS
Hutchinson Gilford syndrome
Hutchinson-Gilford Progeria syndrome
Hutchinson-Gilford disease
progeria
An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Adrenal cortical carcinoma
carcinoma of the Adrenal cortex
adrenocortical carcinoma
An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.
adrenal cancer
adrenal neoplasm
malignant Adrenal tumor
malignant neoplasm of adrenal gland
neoplasm of adrenal gland
tumor of the Adrenal gland
adrenal gland cancer
An adrenocortical carcinoma that originates in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin.
Adrenal cortex adenocarcinoma
adrenal cortical adenocarcinoma
A differentiated thyroid gland carcinoma that has_material_basis_in follicular cells.
Follicular adenocarcinoma
Follicular adenocarcinoma, well differentiated
Follicular carcinoma
Thyroid adenocarcinoma
thyroid gland follicular carcinoma
follicular thyroid carcinoma
A thyroid gland cancer that has_material_basis_in epithelial cells.
Thyroid carcinoma
head and neck cancer, Thyroid
thyroid gland carcinoma
A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer and arises from the follicular cells of the thyroid gland.
Papillary carcinoma of the Thyroid gland
Papillary carcinoma of thyroid
thyroid gland papillary carcinoma
papillary thyroid carcinoma
A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PANK2 gene on chromosome 20p13.
Hallervorden-Spatz disease
Hallervorden-Spatz syndrome
NBIA1
Pigmentary pallidal degeneration
brain Iron Accumulation type I syndrome
neurodegeneration with brain iron accumulation 1
pantothenate kinase-associated neurodegeneration
An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.
urinary system cancer
A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
disease
An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary.
ovarian carcinoma
A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder.
bladder transitional cell carcinoma
transitional cell carcinoma of bladder
urinary bladder urothelial carcinoma
urothelial bladder carcinoma
bladder urothelial carcinoma
A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
carcinoma of urinary bladder
bladder carcinoma
A gastrointestinal system disease that is located_in the mouth.
mouth disease
A musculoskeletal system cancer that is located_in muscle.
malignant neoplasm of muscle
malignant tumor of muscle
malignant tumor of the Muscle
myosarcoma
muscle cancer
A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
pancreas adenocarcinoma
adenocarcinoma of the pancreas
pancreatic adenocarcinoma
disorder of liver
hepatic disorder
liver disease
A biliary tract disease located_in one or more bile ducts.
bile duct disorder
disorder of bile duct
bile duct disease
An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.
CA - skin cancer
malignant neoplasm of skin
melanoma and Non-melanoma skin cancer
cancer of skin
skin cancer
An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.
autoimmune hypersensitivity disease
hypersensitivity reaction type II disease
autoimmune disease
A metal metabolism disorder that is characterized by end-organ resistance to parathyroid hormone and/or a constellation of symptoms collectively termed Albright’s hereditary osteodystrophy, which include shortening and widening of long bones located_in the hand or located_in the foot along with short stature, obesity, and rounded face.
PHP
pseudohypoparathyroidism
A myopathy that is characterized by hypotonia, muscle weakness, and delayed development of motor skills.
congenital structural myopathy
An endometrial stromal tumor that has_material_basis_in connective tissue.
ESS
Undifferentiated endometrial sarcoma
endometrial stromal sarcoma, high grade
endometrial stromal sarcoma
A muscular disease in which the muscle fibers do not function resulting in muscular weakness.
myopathy
A prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain.
Gerstmann-Straussler-Scheinker disease
PRION DEMENTIA
Gerstmann-Straussler-Scheinker syndrome
A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes.
Alexander's disease
Alexander disease
Protocoproporphyria
Protoporphyrinogen oxidase deficiency
variegate porphyria
A female reproductive organ cancer that is located_in the cervix.
cervical neoplasm
cervix cancer
cervix uteri cancer
neoplasm of uterine cervix
tumor of the Cervix Uteri
uterine cervical neoplasm
cervical cancer
An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath.
myasthenia gravis
An autoimmune disease affecting the nervous system.
autoimmune nervous system disorder
autoimmune disease of the nervous system
A neuropathy that affect the nerves that control the voluntary muscles.
neuromuscular disease
A sphingolipidosis characterized by dysfunctional metabolism of sphingolipids.
Sea-blue histiocyte syndrome
sea-blue histiocytosis
Somatostatin cell neoplasm
Somatostatin cell tumour
somatostatinoma
A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.
RCC
adenocarcinoma of kidney
hypernephroma
renal cell carcinoma
A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).
carcinoma of kidney
kidney carcinoma
renal carcinoma
A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.
Clear cell carcinoma of kidney
clear cell kidney carcinoma
conventional (Clear cell) renal cell carcinoma
conventional renal cell carcinoma
renal clear cell carcinoma
Clear-cell metastatic renal cell carcinoma
MESH:C538445 added from NeuroDevNet [WAK].
clear cell renal cell carcinoma
An osteochondrodysplasia that is characterized by short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and midface hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, genu varum, and trident hand and that has_material_basis_in heterozygous mutation in the fibroblast growth factor receptor-3 gene (FGFR3) on chromosome 4p16.3. Achondroplasia results in dwarfism due to the abnormal ossification of cartilage in the long bone.
Achondroplastic physique
Chondrodystrophia
osteosclerosis congenita
achondroplasia
A syndrome that is characterized by malformations of the face, oral cavity, and digits.
oral-facial-digital syndrome
orofaciodigital syndrome
A thyroid gland cancer that is located_in the supporting cells of the thyroid.
sarcoma of the Thyroid gland
thyroid sarcoma
large cell carcinoma of lung
large cell lung carcinoma
lung large cell carcinoma
A biliary tract cancer that is located_in the bile duct.
Ca extrahepatic bile ducts
bile duct tumor
malignant neoplasm of the extrahepatic bile duct
bile duct cancer
A hepatobiliary system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct.
malignant tumour of biliary tract
biliary tract cancer
A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies.
Holoprosencephaly sequence
holoprosencephaly
Retinal tumor
malignant Retinal neoplasm
malignant neoplasm of retina
malignant tumor of retina
neoplasm of retina
retinal cancer
A retinoblastoma that refers to bilateral retinoblastoma associated with an intracranial primitive neuroectodermal tumor located_in the pineal or suprasellar region.
trilateral retinoblastoma
A breast carcinoma that represents a mixed group of malignant neoplasms characterized by the histologic presence of two or more cellular types.
Metaplastic carcinoma of the breast
metaplastic carcinoma of breast
breast metaplastic carcinoma
A GM2 gangliosidosis that is characterized by normal hexosaminidase A (HEXA) and hexosaminidase B (HEXB) but the inability to form a functional GM2 activator complex.
GM2 Activator Deficiency
Tay-Sachs disease AB variant
Tay-Sachs disease, variant AB
GM2 gangliosidosis, AB variant
A reproductive system disease that affects male reproductive organs.
male reproductive system disease
A brain disease that is characterized by a clinical syndrome of either hyperkinetic movement or hyperkinetic movement unrelated to weakness or spasticity.
movement disease
A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.
Janz syndrome
juvenile myoclonic epilepsy
A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
bile duct carcinoma
A pancreas cancer that derives_from epithelial cells located_in the exocrine pancreas.
Exocrine pancreas carcinoma
carcinoma of pancreas
Pancreatic carcinoma, familial
exocrine cancer
pancreatic carcinoma
An esophageal carcinoma that derives_from epithelial cells of glandular origin.
Oesophageal adenocarcinoma
esophagus adenocarcinoma
carcinoma of kidney Pelvis
malignant neoplasm of renal pelvis
malignant renal Pelvis neoplasm
malignant tumor of renal pelvis
renal pelvis cancer
renal pelvis carcinoma
A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
cancer of the gallbladder
carcinoma gallbladder
carcinoma of gallbladder
gallbladder carcinoma
A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow.
bone Marrow tumor
bone marrow neoplasm
malignant bone Marrow tumor
malignant neoplasm of bone marrow
bone marrow cancer
A syndrome that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.
Langer-Giedion syndrome
Trichorhinophalangeal dysplasia type II
trichorhinophalangeal syndrome type 2
trichorhinophalangeal syndrome type II
A gastrointestinal system cancer that is located_in the esophagus.
Ca lower third oesophagus
Ca middle third oesophagus
esophagus cancer
malignant neoplasm of distal third of esophagus
malignant neoplasm of lower third of oesophagus
malignant neoplasm of middle third of oesophagus
malignant neoplasm of proximal third of esophagus
malignant neoplasm of upper third esophagus
malignant tumor of Distal Third of esophagus
malignant tumor of Proximal Third of esophagus
malignant tumor of abdominal esophagus
malignant tumor of the middle Third of the esophagus
esophageal cancer
mixed Neuroglial tumor
mixed gliomas
mixed glioma
An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.
Thoracic tumor
thorax cancer
thorax neoplasm
tumor of thorax
thoracic cancer
An uterine corpus cancer that is located_in the muscles of the uterus or located_in other tissues that support the uterus.
sarcoma of Corpus Uteri
sarcoma of uterus
uterine corpus sarcoma
Nonanaplastic renal Wilm's tumor
Nonanaplastic renal Wilm's tumour
renal Wilms' tumour
nonanaplastic renal wilms tumor
renal Wilms' tumor
An artery disease that is characterized by degeneration of the cells composing the aortic wall.
aortic disorder
disorder of the aorta
aortic disease
A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.
fructose 1 phosphate aldolase deficiency
fructose-1,6-diphosphatase deficiency
fructose-1,6-bisphosphatase deficiency
A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids.
carbohydrate-deficient glycoprotein syndrome
congenital disorder of glycosylation
hepatoerythropoietic porphyria
An ovary sarcoma that arises from smooth muscle progenitors.
leiomyosarcoma of Ovary
ovary leiomyosarcoma
A gastrointestinal system disease that is located_in the intestine.
intestinal disease
A cervical adenocarcinoma that derives_from epithelial cells which have clear cytoplasm.
Clear cell carcinoma of the Cervix Uteri
cervical clear cell adenocarcinoma
A ovarian adenocarcinoma that derives_from epithelial cells which have clear cytoplasm.
ovarian clear cell adenocarcinoma
A syndrome characterized by tetraphocomelia, craniofacial anomalies, growth retardation, intellectual disability, and cardiac and renal abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in the ESCO2 gene on chromosome 8p21.1.
LONG BONE DEFICIENCIES ASSOCIATED WITH CLEFT LIP-PALATE
RBS
Roberts-Sc Phocomelia Syndrome
SC phocomelia syndrome
Roberts syndrome
A intestinal disease located in the colon.
colon disorder
colonic disease
A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the lung.
lung small cell carcinoma
oat cell carcinoma
lung oat cell carcinoma
A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.
schizoaffective disorder
A synovium cancer which develops in the synovial membrane of the joints.
synovial sarcoma
A stomach cancer that is located_in the stomach.
cancer of the stomach
carcinoma of stomach
gastric carcinoma
stomach carcinoma
A testicular cancer that has_material_basis_in germ cells.
germ cell tumor of testis
testicular germ cell neoplasm
testicular germ cell cancer
A teratoma that is located_in the mediastinum.
teratoma of mediastinum
mediastinum teratoma
A urinary system disease that is located_in the kidney.
impaired renal function disease
nephropathy
kidney disease
A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations.
Beckwith-Wiedemann syndrome
A lung carcinoma that is located_in large undifferentiated cells.
Giant cell carcinoma
Giant cell lung carcinoma
lung giant cell carcinoma
An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood.
Precursor T Lymphoblastic Leukemia
T Acute Lymphoblastic Leukemia
T-cell acute lymphocytic leukaemia
T-cell leukemia
T-cell lymphoblastic leukemia/lymphoma
acute T cell leukemia
precursor T-lymphoblastic lymphoma/leukemia
T-cell acute lymphoblastic leukemia
An acute lymphocytic leukemia occurring during adulthood.
adult ALL
adult acute lymphoid Leukemia
adult acute lymphocytic leukemia
An eye and adnexa disease that is located_in the eye.
eye disease
Adenosquamous carcinoma of stomach
gastric adenosquamous carcinoma
A neuropathy that is located_in one of the twelve cranial nerves.
Cranial nerve disorder
disorder of cranial nerve
cranial nerve disease
An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.
large intestine cancer
A breast carcinoma that is characterized by an irregular cribriform growth pattern, nuclear grade I in at least 90% of cells, and absent myoepithelial cells.
ductal carcinoma, cribriform type
cribriform carcinoma
An eye disease that is located_in the retina.
retinal disease
A progeroid syndrome characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers and that has_material_basis_in mutations in the WRN gene, on chromosome 8.
Werner's syndrome
adult premature ageing syndrome
adult progeria
Werner syndrome
An adrenal gland cancer that derives_from immature neuroblastic cells.
neuroblastoma of Adrenal gland
adrenal neuroblastoma
An optic nerve disease that is characterized the death of the retinal ganglion cell axons that comprise the optic nerve.
atrophy of optic disc
optic atrophy
A nervous system disease that affects the peripheral nervous system.
peripheral nerve disease
peripheral neuropathy
peripheral nervous system disease
An ovary adenocarcinoma that derives_from the lining of a cavity that produces a serum-like fluid (a serous cavity).
malignant ovarian serous tumor
serous carcinoma of Ovary
ovary serous adenocarcinoma
A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP.
ADA
adenosine deaminase deficiency
pediatric lymphoma
childhood lymphoma
congenital hemolytic anaemia
hereditary hemolytic anaemia
hereditary hemolytic anemia
congenital hemolytic anemia
Urothelial cell carcinoma of renal Pelvis
renal pelvis transitional cell carcinoma
An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.
hypoimmunity
immune deficiency disorder
immunodeficiency syndrome
primary immunodeficiency disease
A heart valve disease that is located_in the aortic valve.
aortic valve disease
A combined T cell and B cell immunodeficiency that is caused by a defect in infection-fighting immune cells resulting in individuals with non-functional immune systems.
SCID
combined T and B cell inborn immunodeficiency
severe combined immunodeficiency
A disease that has_material_basis_in genetic variations in the human genome.
genetic disease
Ventricular septal defect with pulmonary stenosis or atresia, dextraposition of aorta, and hypertrophy of right ventricle
tetralogy of Fallot
A hamartoma syndrome characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium.
Cowden disease
multiple hamartoma syndrome
Cowden syndrome
A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins.
Prion disease pathway
Prion protein disease
Spongiform Encephalopathy
prion induced disorder
transmissible spongiform encephalopathy
prion disease
A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage.
connective tissue disorder
disorder of connective tissue
connective tissue disease
A disease of metabolism that is characterized by enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality.
Inborn Errors of Metabolism
Metabolic hereditary disorder
inborn metabolism disorder
inherited metabolic disorder
tubular adenocarcinoma of stomach
gastric tubular adenocarcinoma
Adrenal cortical tumors
malignant Adrenocortical tumor
malignant neoplasm of adrenal cortex
malignant tumour of adrenal cortex
neoplasm of adrenal cortex
adrenal cortex cancer
An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain.
cerebrovascular disorder
cerebrovascular disease
An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.
Palatoschisis
cleft palate
A movement disease that is characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain.
Steele-Richardson-Olszewski syndrome
progressive supranuclear ophthalmoplegia
progressive supranuclear palsy
A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Hepatoma
hepatocellular carcinoma
A liver cancer that has_material_basis_in epithelial cells.
Liver and Intrahepatic bile duct carcinoma
liver carcinoma
A myopathy that is characterized by mitochondrial dysfunction.
mitochondrial myopathy
A disease that manifests in a defined anatomical structure.
disease of anatomical entity
A teeth hard tissue disease characterized by presence of normal enamel but atypical dentin with abnormal pulpal morphology.
Dentinal dysplasia
dentin dysplasia
Leber's hereditary optic neuropathy
Leber's optic atrophy
Leber hereditary optic neuropathy
mature B-cell lymphocytic neoplasm
mature B-cell neoplasm
A non-Hodgkin lymphoma that has_material_basis_in B cells.
B-cell lymphocytic neoplasm
B-cell lymphoma
An anemia that is characterized by circulating red blood cells that are the same size and have a normal red color and a mean corpuscular volume (MCV) between 80 and 100 fL.
ANEMIA NORMOCYTIC
Normocytic normochromic anemia
normocytic anemia
An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.
neoplasm of urinary system
tumor of the urinary system
tumor of urinary tract
urinary tract neoplasm
urinary system benign neoplasm
A disease of anatomical entity that has_material_basis_in hematopoietic cells.
Blood disease
Blood dyscrasia
DISEASE OF THE BLOOD AND BLOOD-FORMING ORGANS
Hematological disease
blood disorder
disease of haematopoietic system
disease of hematopoietic system
haematopoietic system disease
hematopoietic system disease
A syndrome characterized by chromosomal instability, microcephaly, growth retardation, immunodeficiency, cellular hypersensitivity to X-rays, and predisposition to cancer that has_material_basis_in homozygous or compound heterozygous mutation in NBN on chromosome 8q21.3.
Berlin breakage syndrome
Microcephaly, normal intelligence and immunodeficiency
NBS
Seemanova syndrome II
Seemanova syndrome type 2
ataxia-telangiectasia variant
immunodeficiency-microcephaly-chromosomal instability syndrome
microcephaly-immunodeficiency-lymphoreticuloma syndrome
Nijmegen breakage syndrome
An immune system disease that is located_in the lymphatic system.
Lymphangiopathy
Lymphatic disease
disease of lympoid system
disorder of lymph node and lymphatics
disorder of lymphatic system
disorder of lymphoid system
lymphatic disorder
lympoid system disease
lymphatic system disease
A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.
RB - Retinoblastoma
neuroblastoma of Retina
retinoblastoma
An autonomic nervous system neoplasm that derives_from immature nerve cells.
neuroblastoma
A disease of anatomical entity that is located_in the gastrointestinal tract.
GIT disease
Gastroenteropathy
alimentary system disease
digestive system disorder
gastrointestinal disease
gastrointestinal disorder
gastrointestinal system disease
A leukemia that occurs in children.
childhood leukemia
Signet Ring cell adenocarcinoma of the stomach
gastric signet ring cell adenocarcinoma
Angiomyolipoma of kidney
renal Angiomyolipoma
kidney angiomyolipoma
A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina.
degeneration of retina
retinal degeneration
A myeloid leukemia that is characterized by over production of white blood cells.
CML
CML - chronic Myelogenous Leukemia
Myeloid Leukemia, chronic
chronic granulocytic leukaemia
chronic granulocytic leukemia
chronic myelogenous leukaemia
chronic myelogenous leukemia
chronic myeloid leukaemia
chronic myeloid leukemia
A multiple carboxylase deficiency that involves a deficiency in biotinidase as the body is not able to use biotin and results in biotin deficiency, and has_material_basis_in homozygous or compound heterozygous mutation in the BTD gene on chromosome 3p25.
BTD deficiency
Juvenile-onset multiple carboxylase deficiency
Late-onset multiple carboxylase deficiency
deficiency of biotinidase
biotinidase deficiency
A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell.
Hodgkin disease
Hodgkin lymphoma
Hodgkin's sarcoma
Hodgkins lymphoma
stage I Subdiaphragmatic Hodgkin Lymphoma
stage II Subdiaphragmatic Hodgkin Lymphoma
Hodgkin's lymphoma
An amino acid metabolic disorder that involves failures of carboxylation enzymes.
multiple carboxylase deficiency
A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.
Left-sided ulcerative colitis
ulcerative colitis
A mature B-cell neoplasm of B-cells found in the germinal center.
Burkitt lymphoma/leukaemia
Burkitt's Lymphoma
Burkitt's tumor
Burkitt's tumor or lymphoma
malignant lymphoma, Burkitt's type
small Non-Cleaved cell Lymphoma, Burkitt's type
Burkitt lymphoma
A multiple carboxylase deficiency that involves a deficiency in holocarboxylase synthetase.
Biotin-(propionyl-CoA-carboxylase) ligase deficiency
Multiple carboxylase deficiency - neonatal onset
holocarboxylase synthetase deficiency
malignant Gingival tumor
malignant neoplasm of gum
malignant neoplasm of other sites of gum
malignant tumor of gum
malignant tumour of gingiva
gum cancer
A gastrointestinal system cancer that is located_in the oral cavity.
malignant neoplasm of floor of mouth
oral cavity cancer
A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.
nervous system disease
malignant neoplasm of tongue
tongue cancer
A leukemia that is located_in myeloid tissue.
Non-Lymphocytic Leukemia
leukaemia myelogenous
leukemia myelogenous
myeloid granulocytic leukaemia
myeloid granulocytic leukemia
myeloid leukaemia
myeloid leukemia
A nervous system disease that is located_in nerves or nerve cells.
neuropathy
This disease may be obsoleted in the future. Diseases previously classified as neurofibromatosis 2 (DOID:0111252) and neurofibromatosis 3 (DOID:0070480 and DOID:0070481) have been reclassified by international consensus as subclasses of schwannomatosis. For details refer to definition sources for neurofibromatosis 1 (DOID:0111253).
neurofibromatosis
An oral cavity cancer that is located_in the salivary gland.
malignant neoplasm of salivary gland
salivary gland cancer
A monocytic leukemia where the majority of monocytic cells are promonocytes.
acute Monoblastic Leukemia and acute Monocytic Leukemia
acute monocytic leukaemia
acute monocytic leukaemia without mention of remission
acute monocytic leukemia without mention of remission
acute monocytic leukemia, FAB M5
acute monocytic leukemia, morphology
acute monocytic leukemia
A skin cancer that has_material_basis_in melanocytes.
Cutaneous Malignant Melanoma
cutaneous melanoma
malignant ear melanoma
malignant lip melanoma
malignant lower limb melanoma
malignant melanoma of ear and/or external auricular canal
malignant melanoma of skin of lower limb
malignant melanoma of skin of trunk except scrotum
malignant melanoma of skin of upper limb
malignant neck melanoma
malignant scalp melanoma
malignant trunk melanoma
malignant upper limb melanoma
OMIM IDs, MIM:612263 and MIM:608035 represent susceptibility loci[LS].
skin melanoma
A metal metabolism disease that is characterized by excess copper stored in various body tissues, particularly the liver, brain, and corneas of the eyes.
Cerebral pseudosclerosis
Westphal pseudosclerosis
Westphal-Strumpell syndrome
Wilson's disease
hepatolenticular degeneration
Wilson disease
A microcytic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes).
ANEMIA SIDEROBLASTIC
Anemia, hypochromic with iron loading
sideroblastic anemia
An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals.
inborn metal metabolism disorder
metal metabolism disorder
A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion.
ADPKD
Congenital biliary ectasias
POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1
Xref MGI. OMIM mapping confirmed by DO. [SN]. Updating outdated UMLS CUI. Removing Caroli disease as a synonym as this is a distinct disease.
autosomal dominant polycystic kidney disease
A peroxisomal biogenesis disorder that is characterized by severe neurologic dysfunction, craniofacial abnormalities, and liver dysfunction, and biochemically by the absence of peroxisome and that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes.
cerebrohepatorenal syndrome
congenital iron overload
OMIM mapping confirmed by DO. [LS]. OMIM mapping confirmed by DO. [SN].
Zellweger syndrome
An inherited metabolic disorder that involves peroxisome malfunction.
peroxisomal disorder
peroxisomal disease
primary macroglobulinemia
macroglobulinemia
A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
AML - acute Myeloid Leukemia
Leukemia, Myelocytic, acute
acute myeloblastic leukaemia
acute myeloblastic leukemia
acute myelogenous leukaemia
acute myelogenous leukemia
acute myeloid leukaemia
acute myeloid leukemia
A syndrome that is characterized by abnormal immune system function and a reduced ability to form blood clots resulting from a decrease in the number and size of blood cell fragments involved in clotting (microthrombocytopenia).
Wiskott syndrome
Wiskott-Aldrich syndrome
malignant neoplasm of submaxillary gland
malignant tumor of submandibular gland
malignant tumor of the Submandibular gland
submandibular gland cancer
A liver disease that is characterized by an accumulation of bile in the liver resulting from a reducted number of liver small bile ducts.
Alagille-Watson syndrome
Arteriohepatic dysplasia
Alagille syndrome
An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids.
inborn errors of amino acid metabolism
amino acid metabolic disorder
A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.
Wilhemsen-Lynch disease
frontotemporal lobar degeneration
multiple system tauopathy with presenile dementia
pallidopontonigral degeneration
frontotemporal dementia
A large intestine cancer that is located_in the colon and/or located_in the rectum.
colorectal cancer
An amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine in the urine.
CBS deficiency
cystathionine beta synthase deficiency
cystathionine synthase deficiency
homocystinuria
An amino acid metabolic disorder that involves the formation of cystine stones in the kidneys, ureter, and bladder.
cystinuria
An amino acid metabolic disorder that involves a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream.
disorder of metabolism of ornithine, citrulline, argininosuccinic acid, arginine and ammonia
disorder of urea cycle metabolism
urea cycle defect
urea cycle disorder
An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.
Ketoacidaemia
branched chain ketoaciduria
dihydrolipoamide dehydrogenase deficiency
maple syrup urine disease
An amino acid metabolic disorder that involves phenylalanine and tyrosine metabolism with the accumulation of homogentisic acid, a toxic tyrosine byproduct.
Homogentisate 1,2-dioxygenase deficiency
alcaptonuria
deficiency of homogentisicase
alkaptonuria
An urea cycle disorder that involves a mutated and ineffective form of the enzyme ornithine transcarbamylase.
deficiency of citrulline phosphorylase
ornithine transcarbamylase deficiency
ornithine carbamoyltransferase deficiency
An inherited urea cycle disorder that involves the accumulation of ammonia and other toxic substances in the blood.
ASS deficiency
deficiency of citrulline-aspartate ligase
citrullinemia
An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood.
hyperlysinemia
An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine.
tyrosinemia
An urea cycle disorder that involves arginase deficiency resulting in elevated levels of plasma arginine.
Arginase deficiency
argininemia
deficiency of canavanase
hyperargininemia
A urea cycle disorder that involves accumulation of ammonia in the blood.
CPS I deficiency
carbamoyl phosphate synthetase I deficiency disease
An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.
Folling's disease
PKU
maternal phenylketonuria
phenylalaninemia
phenylketonuria
An orofacial cleft that is characterized by a congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences.
Labium leporinum
cheiloschisis
cleft lip, unilateral, complete
complete unilateral cleft lip
hare lip
cleft lip
A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
diabetes
diabetes mellitus
A central nervous system disease that is located_in the brain.
encephalopathy
brain disease
A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues.
Lipoid storage diseas
inborn lipid storage disorder
lipoidosis
lipid storage disease
A myeloid neoplasm that is located_in the plasma cells in bone marrow.
myeloma
multiple myeloma
An endocrine system disease that is located_in the adrenal gland.
adrenal gland disease
A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.
IDDM
insulin-dependent diabetes mellitus
type I diabetes mellitus
type 1 diabetes mellitus
progressive Choroidal Atrophy
choroideremia
A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues.
Galactosaemia
Galactose intolerance
galactosemia
A myopathy is characterized by progressive skeletal muscle weakness degeneration.
muscular dystrophy
A acute leukemia that is characterized by over production of lymphoblasts.
ALL
acute lymphoblastic leukaemia
acute lymphocytic leukaemia
precursor lymphoblastic lymphoma/leukemia
acute lymphoblastic leukemia
A congenital heart disease characterized by abnormal development of the left-sided structures of the heart.
hypoplastic left heart syndrome
An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
obesity
A material part of an astronomical body.
geophysical entity
An environmental system which includes both living and non-living components.
ecosystem
A process in which includes the components of an environmental system as participants.
environmental system process
A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
This is the same as GO molecular function
gene product or complex activity
A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
biological process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
metabolic process resulting in cell growth
non-developmental growth of a unicellular organism
The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
Disassembly of actin filaments by the removal of actin monomers from a filament.
The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
This is not covalently bonded, which conflicts with changes to the parent definition.
Self-propelled movement of a cell or organism from one location to another.
Any constituent part of a virion, a complete fully infectious extracellular virus particle.
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
Components are larger than individual macromolecular entities. It is tricky to define distinction between 'cell component' and 'macromolecular entity', e.g. ribosome. We would like to exclude most protein complexes.
Overlaps with some cellular components from GO
A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved.
objective specification
A directive information entity that describes an action the bearer will take.
action specification
data entity
An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.
data item
information content entity
A generically dependent continuant that is about some thing.
Pier: 'data, information or knowledge'. OR 'representation'
An information content entity whose concretizations indicate to their bearer how to realize them in a process.
directive information entity
curation status specification
The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value.
Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)
data about an ontology part
Data about an ontology part is a data item about a part of an ontology, for example a term
A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified.
plan specification
A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device.
measurement datum
obsolescence reason specification
The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value.
The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology.
PERSON: Melanie Courtot
denotator type
The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are "natural kinds" and the latter arbitrary collections of entities.
A denotator type indicates how a term should be interpreted from an ontological perspective.
Barry Smith, Werner Ceusters
ontology module
I have placed this under 'data about an ontology part', but this can be discussed. I think this is OK if 'part' is interpreted reflexively, as an ontology module is the whole ontology rather than part of it.
ontology file
This class and it's subclasses are applied to OWL ontologies. Using an rdf:type triple will result in problems with OWL-DL. I propose that dcterms:type is instead used to connect an ontology URI with a class from this hierarchy. The class hierarchy is not disjoint, so multiple assertions can be made about a single ontology.
base ontology module
An ontology module that comprises only of asserted axioms local to the ontology, excludes import directives, and excludes axioms or declarations from external ontologies.
editors ontology module
An ontology module that is intended to be directly edited, typically managed in source control, and typically not intended for direct consumption by end-users.
source ontology module
main release ontology module
An ontology module that is intended to be the primary release product and the one consumed by the majority of tools.
TODO: Add logical axioms that state that a main release ontology module is derived from (directly or indirectly) an editors module
bridge ontology module
An ontology module that consists entirely of axioms that connect or bridge two distinct ontology modules. For example, the Uberon-to-ZFA bridge module.
import ontology module
A subset ontology module that is intended to be imported from another ontology.
TODO: add axioms that indicate this is the output of a module extraction process.
import file
subset ontology module
An ontology module that is extracted from a main ontology module and includes only a subset of entities or axioms.
ontology slim
subset ontology
curation subset ontology module
A subset ontology that is intended as a whitelist for curators using the ontology. Such a subset will exclude classes that curators should not use for curation.
analysis ontology module
An ontology module that is intended for usage in analysis or discovery applications.
analysis subset ontology module
single layer ontology module
A subset ontology that is largely comprised of a single layer or strata in an ontology class hierarchy. The purpose is typically for rolling up for visualization. The classes in the layer need not be disjoint.
ribbon subset
single layer subset ontology module
exclusion subset ontology module
A subset of an ontology that is intended to be excluded for some purpose. For example, a blacklist of classes.
antislim
external import ontology module
An imported ontology module that is derived from an external ontology. Derivation methods include the OWLAPI SLME approach.
external import
species subset ontology module
A subset ontology that is crafted to either include or exclude a taxonomic grouping of species.
taxon subset
reasoned ontology module
An ontology module that contains axioms generated by a reasoner. The generated axioms are typically direct SubClassOf axioms, but other possibilities are available.
generated ontology module
An ontology module that is automatically generated, for example via a SPARQL query or via template and a CSV.
TODO: Add axioms (using PROV-O?) that indicate this is the output-of some reasoning process
template generated ontology module
An ontology module that is automatically generated from a template specification and fillers for slots in that template.
taxonomic bridge ontology module
ontology module subsetted by expressivity
obo basic subset ontology module
A subset ontology that is designed for basic applications to continue to make certain simplifying assumptions; many of these simplifying assumptions were based on the initial version of the Gene Ontology, and have become enshrined in many popular and useful tools such as term enrichment tools. Examples of such assumptions include: traversing the ontology graph ignoring relationship types using a naive algorithm will not lead to cycles (i.e. the ontology is a DAG); every referenced term is declared in the ontology (i.e. there are no dangling clauses). An ontology is OBO Basic if and only if it has the following characteristics: DAG Unidirectional No Dangling Clauses Fully Asserted Fully Labeled No equivalence axioms Singly labeled edges No qualifier lists No disjointness axioms No owl-axioms header No imports
ontology module subsetted by OWL profile
EL++ ontology module
Fryns syndrome (FS) is a multiple congenital anomaly syndrome characterized by dysmorphic facial features, congenital diaphragmatic hernia, pulmonary hypoplasia, and distal limb hypoplasia, in addition to variable expression of additional malformations.
A process in which at least one of the participants is a molecule.
This is meant to capture processes that are more fundamental than macromolecular activities
Djungarian hamster also in use for Phodopus campbelli
virus
African green monkey lymphotropic papovavirus LPV
ducks, geese, chickens, fowl, quail, currasows and allies
a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s).
investigation
A planned process that has the objective to produce information about a material entity (the evaluant) by examining it.
assay
A growth medium or culture medium is a substance in which microorganisms or cells can grow. Wikipedia, growth medium, Feb 29, 2008
a processed material that provides the needed nourishment for microorganisms or cells grown in vitro.
changed from a role to a processed material based on on Aug 22, 2011 dev call. Details see the tracker item: http://sourceforge.net/tracker/?func=detail&aid=3325270&group_id=177891&atid=886178 Modification made by JZ.
Person: Jennifer Fostel, Jie Zheng
OBI
culture medium
organization
PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods.
An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members.
BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that. The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based: 1) there are organization_member_roles (president, treasurer, branch editor), with individual persons as bearers 2) there are organization_roles (employer, owner, vendor, patent holder) 3) an organization has a charter / rules / bylaws, which specify what roles there are, how they should be realized, and how to modify the charter/rules/bylaws themselves. It is debatable what the organization itself is (some kind of dependent continuant or an aggregate of people). This also determines who/what the bearer of organization_roles' are. My personal favorite is still to define organization as a kind of 'legal entity', but thinking it through leads to all kinds of questions that are clearly outside the scope of OBI. Interestingly enough, it does not seem to matter much where we place organization itself, as long as we can subclass it (University, Corporation, Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO, W3C, University of Oklahoma), and have it play roles. This leads to my proposal: We define organization through the statements 1 - 3 above, but without an 'is a' statement for now. We can leave it in its current place in the is_a hierarchy (material entity) or move it up to 'continuant'. We leave further clarifications to BFO, and close this issue for now.
plan
The plan of researcher X to perform an experiment according to a protocol.
A plan is a realizable entity that is the inheres in a bearer who is committed to realizing it as a completely executed planned process.
This class is included to make clear how the plan specification, the plan, and the planned process relate. OBI will however only subclass and work under the 'plan specification', and 'planned process' class, as we want to avoid to get deep into discussions of 'intend' etc.
AR, BP, JM, MC, PRS
branch derived
Taped, glued, pinned, dried or molecularly bonded to a solid support
A solid support function is a function of a device on which an entity is kept in a defined position and prevented in its movement
solid support function
The objective to create a mouse infected with LCM virus. The objective to create a defined solution of PBS.
an objective specifiction that creates an specific output object from input materials.
artifact creation objective
material transformation objective
A planned process with the objective to produce a processed material which will have a function for future use.
A person or organization (having manufacturer role) is a participant in this process
Manufacturing implies reproducibility and responsibility AR
This includes a single scientist making a processed material for personal use.
manufacturing
is the objective to manufacture a material of a certain function (device)
manufacturing objective
With respect to The Accuri C6 Flow Cytometer System, the organization Accuri bears the role manufacturer role. With respect to a transformed line of tissue culture cells derived by a specific lab, the lab whose personnel isolated the cll line bears the role manufacturer role. With respect to a specific antibody produced by an individual scientist, the scientist who purifies, characterizes and distributes the anitbody bears the role manufacturer role.
Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process.
The objective to obtain multiple aliquots of an enzyme preparation. The objective to obtain cells contained in a sample of blood.
is an objective to transform a material entity into spatially separated components.
The objective to obtain multiple aliquots of an enzyme preparation.
A material separation objective aiming to separate material into multiple portions, each of which contains a similar composition of the input material.
separation into different composition objective
The objective to obtain cells contained in a sample of blood.
A material separation objective aiming to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities).
We should be using has the grain relations or concentrations to distinguish the portioning and other sub-objectives
An objective specification maintains some or all of the qualities of a material over time.
A person or organization that has a manufacturer role.
A planned process with the objective to maintain some or all of the characteristics of an input material over time.
Establishment of HeLa immortal cell line
is a planned process in which the objective is to generate a cell line from a natural population of cancer cells which are already immortal
Production of a cell line for the purposes of experimentation e.g. EBV transformation of PBMs
an establishing cell line process whereby a mortal cell line is intentionally genetically modified to be capable of indefinite propagation and re-established as a new immortal cell line
4-20-13 MHB: This class was repositioned as a child of 'establishing cell line', based on the existing definition ("the planned process of experimentally creating a cell line which is capable of dividing indefinitely in vitro"), and examples and other annotations indicating the intent to describe a process through which a new immortal cell line is established from an existing mortal cell line using genetic modification techniques. The definition above was modified to clarify this perspective.
'establishing immortal cell line through directed genetic modification'
A immortalizing genetic transformation of an existing population of cell line cells is required as part of this process, as are additional steps for selecting and propagating the cells output form this process into a cell line.
genetically modified material
a material entity, organism or cell, that is the output of a genetic transformation process.
PERSON: Jie Zheng
GROUP: OBI
term is proposed by BP on Oct 25, 2010 dev call
genetic transformation objective
a material transformation objective aims to create genetically modified organism or cell
Person: Jie Zheng
suggested to be added by BP and AR during Oct 25, 2010 dev call
A device made to be used in an analyte assay for immobilization of substances that bind the analyte at regular spatial positions on a surface.
PERSON: Chris Stoeckert, Jie Zheng, Alan Ruttenberg
A cultured cell that has been passaged or derives from a cell that has been passaged in culture.
The term 'secondary cell culture' is generally used in biological texts/protocols to refer to any culture following an initial passage. We include it here because there are often a number of passages between a primary culture and the establishment of a stable, homogenous cell line. Such cultures are considered to be 'secondary cultures' but not 'cell lines' during this intermediate passaging/selection period between their derivation from a 'primary cell culture' and derivation into a 'cell line', which is a more specific type of secondary culture.
A secondary cultured cell has been passaged in culture or is a descendant of such a cell that is derived through propagation in culture.
a process whereby a new type of cell line is created, either through passaging of a primary cell culture to relative genetic stability and compositional homogeneity, or through some experimental modification of an existing cell line to produce a new line with novel characteristics (e.g. immortalization or some other stable genetic modification, or selection of some defined subset).
2013-4-20 MHB: For cases of initial establilshment of a line from a primary culture, successive passaging and/or selection processes can confer increasing degrees of genetic stability and compositional homogeneity as compared to the input primary culture. Historically, many texts consider the first passage as the clearest point to define the beginning of a line. However, in practice it is more often that case that more than one passage, and possibly additional selective techniques, may be required before a culture is deemed to have sufficient stability and homogeneity to be considered cell line. This is the view taken in OBI. Regardless, what is important is that some intentional, experimental step has been taken to establish a more homogenous and stable culture that can be characterized and progatated over time.
An array that consists of 3-micron silica beads that self assemble in microwells on either of two materials: fiber optic bundles or planar silica slides.
PERSON: Chris Stoeckert, Jie Zheng, Alan Ruttenberg, Venkat Malladi
An immortal cell line derived from a transformed cell that was part of a malignant tumor.
a genetic transformation of a cell line cell with transgenic constructs intended to confer the capability for indefinite propagation in culture
A processed material that serves as a liquid vehicle for freezing cells for long term quiescent stroage, which contains chemicls needed to sustain cell viability across freeze-thaw cycles.
cell freezing medium
A cultured cell population applied in an experiment: "293 cells expressing TrkA were serum-starved for 18 hours and then neurotrophins were added for 10 min before cell harvest." (Lee, Ramee, et al. "Regulation of cell survival by secreted proneurotrophins." Science 294.5548 (2001): 1945-1948). A cultured cell population maintained in vitro: "Rat cortical neurons from 15 day embryos are grown in dissociated cell culture and maintained in vitro for 8–12 weeks" (Dichter, Marc A. "Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation." Brain Research 149.2 (1978): 279-293).
A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history.
2013-6-5 MHB: This OBI class was formerly called 'cell culture', but label changed and definition updated following CLO alignment efforts in spring 2013, during which the intent of this class was clarified to refer to portions of a culture or line rather than a complete cell culture or line.
The extent of a 'cultured cell population' is restricted only in that all cell members must share a propagation history (ie be derived through a common lineage of passages from an initial culture). In being defined in this way, this class can be used to refer to the populations that researchers actually use in the practice of science - ie are the inputs to culturing, experimentation, and sharing. The cells in such populations will be a relatively uniform population as they have experienced similar selective pressures due to their continuous co-propagation. And this population will also have a single passage number, again owing to their common passaging history. Cultured cell populations represent only a collection of cells (ie do not include media, culture dishes, etc), and include populations of cultured unicellular organisms or cultured multicellular organism cells. They can exist under active culture, stored in a quiescent state for future use, or applied experimentally.
A completely executed planned process that produces output data from input data.
data transformation
A protocol for removal of antibiotic resistance cassettes from human embryonic stem cells genetically modified by homologous recombination or transgenesis. Nat Protoc. 2008;3(10):1550-8. PMID: 18802436
an organism that is the output of a genetic transformation process
OBI Biomaterial
genetically modified organism
material component separation
Using a cell sorter to separate a mixture of T cells into two fractions; one with surface receptor CD8 and the other lacking the receptor, or purification
a material processing in which components of an input material become segregated in space
Bjoern Peters
IEDB
maintaining cell culture
When harvesting blood from a human, isolating T cells, and then limited dilution cloning of the cells, the maintaining_cell_culture step comprises all steps after the initial dilution and plating of the cells into culture, e.g. placing the culture into an incubator, changing or adding media, and splitting a cell culture
A planned process with the objective to keep cells alive in a defined environment outside of an organism.
PlanAndPlannedProcess Branch
OBI branch derived
a process through which a new type of cell culture or cell line is created, either through the isolation and culture of one or more cells from a fresh source, or the deliberate experimental modification of an existing cell culture (e.g passaging a primary culture to become a secondary culture or line, or the immortalization or stable genetic modification of an existing culture or line).
A 'cell culture' as used here referes to a new lineage of cells in culture deriving from a single biological source.. New cultures are established through the initial isolation and culturing of cells from an organismal source, or through changes in an existing cell culture or line that result in a new culture with unique characteristics. This can occur through the passaging/selection of a primary culture into a secondary culture or line, or experimental modifications of an existing cell culture or line such as an immortalization process or other stable genetic modification. This class covers establishment of cultures of either multicellular organism cells or unicellular organisms.
cell culture splitting
The act of taking a cell culture of high density, counting the cells, removing part of the cells, and re-seeding a select number of the cells into new flasks with fresh tissue culture media.
The act of taking part of a homogeneous cell culture and creating one or more additional separate cultures of similar qualities. input: cell_culture, output cell_culture min cardinality 2. part of cell culturing
An active cell culture is typically split when it has grown to confluence in its culture dish. Cell culture splitting of a cell culture sample results in an increase in its passage number, which measures how long a sample has been propagated in vitro, and therefore how many selective or genetic changes it is likely to have undergone.
genetic transformation
The transduction of E. coli through the introduction of a plasmid encoding for M. avium p35
the introduction. alteration or integration of genetic material into a cell or organism
PERSON:Kevin Clancy
genetic modification
A time quality inhering in a bearer by virtue of how long the bearer has existed.
An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved.
A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population.
A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population.
A quality which inheres in a continuant.
multiply inhering quality of a physical entity
Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.
A monadic quality of continuant that exists at the cellular level of organisation.
A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types.
A cellular potency that is the capacity to produce differentiated cell types of all three primary germ layers and extraembryonic cell types.
A cellular potency that is the capacity to form multiple differentiated cell types.
A cellular potency that is the capacity to produce differentiated cell types of all three primary germ layers but not extraembryonic cell types.
A viability quality inhering in a bearer by virtue of the cessation of the bearer's life.
A quality inhering in a bearer by virtue of the bearer's disposition to being capable of indefinite growth or division.
A quality that inheres in an entire organism or part of an organism.
A cellular quality inhering in a bearer by virtue of having not yet acquired a special structure of function.
A molecular quality that inheres in a molecular entity by virtue of the overall electric charge of the molecule, which is due to a comparison between the total number of electrons and the total number of protons.
A material entity that consists of two or more organisms, viruses, or viroids.
collection of organisms
An anatomical entity that is or was part of a plant.
An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
Lower, narrow portion of the uterus where it joins with the top end of the vagina.
The narrow caudal end of the uterus that opens into the vagina. [TFD][VHOG]
The evolution of mammals is associated with radical changes in their reproductive biology, particularly the structure and function of the female reproductive organs. These changes include the evolution of the uterus, cervix, vagina, placenta and specialized cell types associated with each of those structures.[well established][VHOG]
The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity.
Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047].
a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose].
the organ that is specialized for smell and is part of the respiratory system
the structure of the nose varies across vertebrates. In tetrapods the nose is part of the respiratory system.[PMID:25312359]
The clusters of hormone-producing cells that are scattered throughout the pancreas.
Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO]
Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG]
A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986)
The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN].
An endocrine gland derived from infundibulum of the floor of the diencephalon and an ectodermal dorsal protrusion from the buccal cavity which controls the secretion of many hormones influencing the function of various organs of the body.[AAO]
An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin.[TAO]
It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]
The lamprey possesses a distinct pituitary organ and hormones, the ascidian does not show distinct evidence of them [Sower S, Freamat M, Kavanaugh S. The origins of the vertebrate hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-thyroid (HPT) endocrine systems: new insights from lampreys. Gen Comp Endocrinol 2009;161:20-9]
Terminology note: hypophysis and pituitary gland are often used informally as synonyms, but the hypophysis also includes the small infundibular or pituitary stalk[Neumann 2020]
Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
somatic nervous system, somatic division
somatic part of peripheral nervous system
Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.
Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee
(...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]
we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive
An organ that is capable of transducing sensory stimulus to the nervous system.
Anatomical projection that protrudes from the skin. Examples: hair, nail, feather, claw, hoof, horn, wattle, spur, beak, antler, bristle and some scales.
Mammary glands develop by similar mechanisms, and there is an argument for including them here (e.g. http://www.ncbi.nlm.nih.gov/pubmed/20484386), but these structures do not fit the current definition (lactiferous glands are part of the integumentary system in FMA). Note the FMA class is a subdivision of epidermis, which may be too restrictive for our purposes here.
Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.
not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts)
Major subdivision of an organism that protrudes from the body[DOS, CARO].
An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018].
Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736].
this is currently a subtype of organism subdivision - which would exclude feathers
Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph.
Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG]
The fluid surrounding the ovum and granulosa cells in the ovarian follicle.
Generally, larger species such as ovine, equine, porcine, human, and bovine have larger follicles, with the fluid comprising a substantial proportion of the volume of the follicles at ovulation (estimated at >95% in bovine [3]). Smaller species such as rats and mice have smaller follicles with fractionally less follicular fluid[20164441]
The follicular fluid contains sex steroids, glycoprotein hormones, plasma proteins, mucopolysaccharides, and enzymes and is rich in hyaluronic acid.
Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.
A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]
a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]
in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. (MSH) * ganglion found on the posterior root of each spinal nerve, composed of the unipolar nerve cell bodies of the sensory neurons of the nerve. (CSP).
Trunk ganglion which is located adjacent to the spine on a dorsal root and contains the cell bodies of afferent sensory nerves.[TAO]
From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG]
The sensory ganglia of spinal nerves arise only from the neural crest, whereas many sensory ganglia of the 'dorsal' cranial nerves arise from epibranchial placodes as well as the neural crest[DOI:10.1093/icb/icn065]
MA and EMAPA introduce distinct classes for what appears to be the same thing
spinal ganglion part of peripheral nervous system
A biological tissue mass, most commonly a mass of nerve cell bodies.
TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.
A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures
Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO]
Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO]
Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NLXANAT:100302].
Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG]
Simple eye that consists of a lens of one refractive index.
A tubular structure that contains, conveys body fluid, such as blood or lymph.
Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs.
Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO]
The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]
The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]
in humans, consists of adventitial, muscular and mucoa layers
The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening.
In human males, the urethra travels through the penis, and carries semen as well as urine. In females, the urethra is shorter and emerges above the vaginal opening.
A tubular structure that transports secreted or excreted substances.
A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171].
Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here.
A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong].
Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]
Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.
Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
Anatomical structure that performs a specific function or group of functions [WP].
Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4
A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.
FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction
Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball.
Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal.
A multicellular structure that is a part of an organ.
currently defined in a very broad sense, may be replaced by more specific classes in the future
A life cycle stage that starts with fertilization and ends with the fully formed embryo.
A life cycle stage of holometabolous insects in which the organism is a pupa and starts with the larval-pupal apolysis and ends with pupal-adult apolysis.
The pupal stage is found only in holometabolous insects, those that undergo a complete metamorphosis, going through four life stages; embryo, larva, pupa and imago
Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.
A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO].
ZFA - The multi-tissue structure where the glomerular basement membrane supported by mesonephric podocytes filters blood from the glomerular capillaries. GUDMAP: 'Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle.' - here the glomerulus is part of the capsule?
Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.
The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.
merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)
(or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis
An anatomical structure that develops from the endoderm and the mesoderm.
Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple
mixed endoderm/mesoderm-derived structure
The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo.
A kidney formed of nephric tubules arising in the middle region of the nephric ridge; a transient embryonic stage that replaces the pronephros, but is itself replaced by the adult metanephros [in mammals; in fishes and amphibians it is the adult kidney]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]
Organ that is the definitive adult kidney. It replaces the earlier pronephros, which degenerates as the mesonephros becomes functional in feeding stage tadpoles.[AAO]
As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates. (...) In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]
In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In fish and amphibians, the mesonephros will form the mature kidney
By contrast to the pronephros, the histological features of the mammalian mesonephros, with its primitive glomeruli, suggest that it probably functions as a primitive kidney, and is involved in the production of much of the amniotic fluid. Within the two mesonephroi, one located on either side of the dorsal mesentery of the hindgut, a substantial number (in the region of about 40 or more) of cranio-caudally segmented mesonephric tubules are formed. It has, however, been suggested that only the most rostrally located 4-6 pairs of mesonephric tubules drain into the mesonephric portion of the nephric duct. This is now seen to extend along the length of the mesonephroi, being located towards their lateral sides. The mesonephros is also retained over a considerably longer period than the pronephros, but gradually undergoes regression in a cranio-caudal direction. While the rostral part displays clear evidence of regression its more caudal part appears to display evidence of functional activity. Within the medial part of the mesonephros, vesicles are formed, although no glomeruli are formed there in this species. It is, however, difficult to believe that the relatively enormous mesonephroi do not have an excretory role in the mouse, only serving as a base for gonadal differentiation. In the human embryo, the medial part of the mesonephric tubules enlarges, become invaginated by capillaries, and form glomeruli. These then take on an excretory role. In the mouse, the mesonephric ducts appear to be patent throughout their length[GUDMAP, modified]
A spatiotemporal region encompassing some part of the life cycle of an organism.
this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here
the WBls class 'all stages' belongs here as it is the superclass of other WBls stages
we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage
A tube in the respiratory system. Examples: bronchus, bronchiole, trachea.
in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class)
Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium.
A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.
A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).
Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021].
Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate.
Paired fin located in the abdominal position of the body.
Paired fin located in the abdominal position of the body.[TAO]
Paired fin located in the abdominal position of the body.[VSAO]
A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures.
Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.
Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO]
The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
In zebrafish, No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type.
Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified].
in FMA, this is an anatomical conduit *space*, rather than anatomical conduit
The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).
Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]
Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]
some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives
in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips
Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present).
Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO]
The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG]
Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG]
The pair of anatomical structures comprised of a left lung and right lung.
Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid.
Pleural effusion is a bodily fluid that is produced in exess and accumulates in the pleural cavity, the fluid-filled space that surrounds the lungs. Excessive amounts of such fluid can impair breathing by limiting the expansion of the lungs during inhalation.
cede to MPATH? Note the ncit class is under finding.
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]
Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]
relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]
Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]
Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.
Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ.
Nonparenchymatous organ that primarily consists of dense connective tissue aggregated into fasciculi by connective tissue. Examples: sutural ligament, radiate sternocostal ligament, ligament of liver, ovarian ligament[FMA][FMA:21496].
Portion of connective tissue that connects bone or cartilage.[TAO]
Compared with their Ediacarian predecessor, Cambrian animals in general were characterized by their much stouter bodies. The stoutness of the body is likely due to the formation of ligaments and tendons, which in turn requires the crosslinking of collagen triple helices.[well established][VHOG]
this groups both skeletal and non-skeletal ligaments. What is called a 'ligament' in many AOs is actually a skeletal ligament
The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected.
A thin but tough extraembryonic membrane of reptiles, birds and mammals that lines the chorion and contains the fEtus and the amniotic fluid around it. [Biology_Online][VHOG]
Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]
The upper ventral region of the torso of an organism.
The breasts of a female primate's body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's.
An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching.
TODO - check fetus/embryo. WP: An embryo is a multicellular diploid eukaryote in its earliest stage of development, from the time of first cell division until birth, hatching, or germination. In humans, it is called an embryo until about eight weeks after fertilization (i.e. ten weeks LMP), and from then it is instead called a fetus.
Fetal structure, which is a developmental form of a vertebrate animal at any given time point from 8 weeks of gestation to birth (or hatching). Examples: There is only one fetus[FMA:63919].
The enlarged basal part of a hair within the skin[BTO]. The root of the hair ends in an enlargement, the hair bulb, which is whiter in color and softer in texture than the shaft, and is lodged in a follicular involution of the epidermis called the hair follicle. [Wikipedia].
A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP].
FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately
The inner portion of the kidney consisting of the renal pyramids.
The renal medulla is split up into a number of sections, known as the renal pyramids. Blood enters into the kidney via the renal artery, which then splits up to form the arcuate arterioles. The arcuate arterioles each in turn branch into interlobular arterioles, which finally reach the glomeruli. At the glomerulus the blood reaches a highly disfavourable pressure gradient and a large exchange surface area, which forces the serum portion of the blood out of the vessel into the renal tubules. Flow continues through the renal tubules, including the proximal tubule, the Loop of Henle, and finally leaves the kidney by means of the collecting duct, leading to the renal ureter. The renal medulla contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. The renal medulla is hypertonic to the filtrate in the nephron and aids in the reabsorption of water
Note that 'renal medulla' is not synonymous with 'medullary region of kidney'. The former is composed of kidney pyramids only, while the latter covers kidney pyramids and renal columns, which are histologically different.
An epithelial tissue layer that lines much of the urinary tract, including the renal pelvis, the ureters, the bladder, and parts of the urethra.
The part of the hindlimb between pelvis and the knee, corresponding to the femur.
Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]
Naming conventions for pod terms under discussion within phenoscape group.
The nasal vestibule is the most anterior part of the nasal cavity. It's enclosed by the cartilages of nose and lined by the same epithelium of the skin. The other part of the nasal cavity, which is lined by the respiratory epithelium, is called nasal cavity proper. [WP,unvetted].
The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendonous galea aponeurotica; Loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).
introducing part_of to 'cortex of lymph node' as in issue 7 introduces equivalencies; the part_of has instead been added to 'lymph node follicle'
Gray matter structure located on the midline of the forebrain consisting of the septum pellucidum (in some species) and the septal nuclei (Heimer, 1996).
Subdivision of the telencephalon on the midline between the lateral ventricles which contains the septum pellucidum and the septal nuclei[FMA][FMA:61842].
The region of the opening of the uterine cervix into the uterine cavity.
Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.
Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.
Anatomical structure that is an individual member of a species and consists of more than one cell.
TODO - split body and mc organism? body continues after death stage
A gonad of a male animal. A gonad produces and releases sperm.
(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]
The testes are descended in metatherian and eutherian mammals, first transabdominally, then inguinoscrotally
Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.
Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency
Anatomical group whose component anatomical structures lie in close proximity to each other.
A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis.
see also conceptus extraembryonic component in EHDAA2.
Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.
changed label and definition to reflect CARO2
Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.
Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].
The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]
Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?
Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA].
Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA].
Epithelium that consists of more than one layer of epithelial cells.[CARO]
Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].
Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]
Compound organ that contains one or more macroscopic anatomical spaces.
this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future
Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].
consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable
Epithelium that consists of a single layer of epithelial cells.[CARO]
Subdivision of trunk that lies between the head and the abdomen.
note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest
Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo
The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms)[BTO]. A large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring[WB]. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms[GO].
A cluster of neurons that extends posteriorly from the embryonic and larval brain and is surrounded by a connective tissue sheath.
The ventral nerve cords make up the nervous system of some phyla of the invertebrates, particularly within the nematodes, annelids and the arthropods. It usually consists of cerebral ganglia anteriorly with the nerve cords running down the ventral ('belly', as opposed to back) plane of the organism. This characteristic is important in qualifying the difference compared to the chordates, which have a dorsal nerve cord. Ventral nerve cords from anterior to posterior (the thoracic and abdominal tagma in the arthropods) are made up of segmented ganglia that are connected by a tract of nerve fibers passing from one side to the other of the nerve cord called commissures. The complete system bears some likeness to a rope ladder. In some animals the bilateral ganglia are fused into a single large ganglion per segment. This characteristic is found mostly in the insects.
Rounded band of white fibers crossing the middle line on the dorsal aspect of the upper end of the cerebral aqueduct. It is important in the bilateral pupillary light reflex. Its fibers acquire their medullary sheaths early, but their connections have not been definitely determined. Most of them have their origin in a nucleus, the nucleus of the posterior commissure (nucleus of Darkschewitsch), which lies in the central gray substance of the upper end of the cerebral aqueduct, in front of the nucleus of the oculomotor nerve. Some are probably derived from the posterior part of the thalamus and from the superior colliculus, whereas others are believed to be continued downward into the medial longitudinal fasciculus. The posterior commissure interconnects the pretectal nuclei, mediating the consensual pupillary light reflex[WP]. Diencephalic tract which is located in the vicinity of the dorsal diencephalon and mesencephalon and connects the pretectal nuclei. From Neuroanatomy of the Zebrafish Brain[ZFA].
add connects relationships and check these outside mammalia
part_of brainstem in MA; midbrain tectum in NIF
An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.
Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]
It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]
We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa
The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation.
This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae.
The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO]
When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]
All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body, and is homologous with the descending aorta of tetrapods. The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches
A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.
Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]
Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]
relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]
As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]
Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706
The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
requires review for applicability to invertebrate structures, e.g. synganglion
Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]
Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]
The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]
The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.
We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus).
The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex].
Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG]
hagfishes have independently evolved a highly laminated cerebral cortex, comparable in many ways to the cerebral cortex of mammals [http://icb.oxfordjournals.org/content/42/4/743]
The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.
Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water
A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina.
The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]
This class excludes compound eye corneal lenses.
The lens is avascular and nourished by diffusion from the aqueous and vitreous humors.
The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]
Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods
This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each)
Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva,
An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column.
true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck.
A midventral endochondral skeletal element which represents the origin site of the pectoral muscles[PHENOSCAPE:ad].
in EMAPA and EHDAA2 this is part of the skeleton of pectoral girdle; the classic def of pectoral girdle (see WP) excludes the rib cage and sternum
Single element that constitutes the postzonal area of the pectoral girdle.[AAO]
relationship loss: part_of postzonal element (AAO:0000938)[AAO]
Fishes lack a sternum. (...) A sternum is absent in the first fossil tetrapods, but it is present in modern amphibians. (...) Thus, a sternum occurs in some modern amphibians, birds, mammals and archosaurs. However, its absence in the common ancestors to these groups means that it has arisen independently several times within the field of the midventral connective tissue.[well established][VHOG]
It probably first evolved in early tetrapods as an extension of the pectoral girdle; it is not found in fish. In amphibians and reptiles it is typically a shield-shaped structure, often composed entirely of cartilage. It is absent in both turtles and snakes. In birds it is a relatively large bone and typically bears an enormous projecting keel to which the flight muscles are attached. Only in mammals does the sternum take on the elongated, segmented form seen in humans. In some mammals, such as opossums, the individual segments never fuse and remain separated by cartilagenous plates throughout life
in birds, either ratite (no keel or carina) or carinate (keel and carina present)
While its developmental origins are similar to the ribs (from the myospetum and septum of the trunk region), it is often associated with the pectoral skeleton, due to both function and physical connections (i.e. the coracoid of archosaurs). It may be a single element or a series of smaller structure (sternebrae). Based on Kardong 2012. [PHENOSCAPE:ad].
The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).
The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]
In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86
The portion of the hindlimb that contains both the stylopod and zeugopod.
The term leg can mean: [1] an appendage on which an animal walks [2] the entire hindlimb of a tetrapod [3] the segment of a human leg between knee and ankle (cf FMA) [4] the region of a hindlimb include the stylopod and zeugopod, but excluding the autopod. We define this class as [4], and thus 'leg' is compltely analagous to 'arm'. For [1], see the class 'locomotive weight-bearing appendage'. For [2] we use 'hindlimb'. For
we use the less open to misinterpretation 'hindlimb zeugopod'. Editor note: currently declared as overlapping foot, as AOs disagree over whether some ankle parts are in the leg or foot
Reproductive organ that produces and releases eggs (ovary) or sperm (testis).
Anatomical structure which produces gametes as well as certain sex hormones controlled by the pituitary gonadotropins.[AAO]
The part of the reproductive system that produces and releases eggs (ovary) or sperm (testis).[TAO]
Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG]
The gonad of a female organism which contains germ cells.
Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]
Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo
female organism reproductive system gonad
female organism reproductive system gonada
gonad of female organism reproductive system
gonad of reproductive system of female organism
gonada of female organism reproductive system
gonada of reproductive system of female organism
reproductive system of female organism gonad
reproductive system of female organism gonada
The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth.
The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG]
An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]
Most animals that lay eggs, such as birds and reptiles, have an oviduct instead of a uterus. In monotremes, mammals which lay eggs and include the platypus, either the term uterus or oviduct is used to describe the same organ, but the egg does not develop a placenta within the mother and thus does not receive further nourishment after formation and fertilization. Marsupials have two uteruses, each of which connect to a lateral vagina and which both use a third, middle 'vagina' which functions as the birth canal. Marsupial embryos form a choriovitelline 'placenta' (which can be thought of as something between a monotreme egg and a 'true' placenta), in which the egg's yolk sac supplies a large part of the embryo's nutrition but also attaches to the uterine wall and takes nutrients from the mother's bloodstream.
Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused [Wikipedia:Uterus]
A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP].
Organ with organ cavity which connects the cervical canal of uterus to the vestibule of vagina.[FMA]
The genital canal in the female, leading from the opening of the vulva to the cervix of the uterus. [TFD][VHOG]
The distal end of the oviducts differentiates as a vagina in Metatheria and Eutheria.[well established][VHOG]
'The distal end of the oviducts differentiates as a vagina in Metatheria and Eutheria.' Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective, Third Edition (2001) Orlando Fla.: Harcourt College Publishers, p.688
External genital organs of the female mammal[WP].
The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG]
A secretory duct that transports sperm from the testis. In mammals this is a continuation of the epididymis and ends in the prostatic urethra where it terminates to form ejaculatory duct.
The continuation of the archinephric duct, now called the deferent duct, extends caudally to the cloaca or to the part of the mammalian urethra that is derived from the cloaca.[well established][VHOG]
Most vertebrates have some form of duct to transfer the sperm from the testes to the urethra. In cartilaginous fish and amphibians, sperm is carried through the archinephric duct, which also partially helps to transport urine from the kidneys. In teleosts, there is a distinct sperm duct, separate from the ureters, and often called the vas deferens, although probably not truly homologous with that in humans. In cartilaginous fishes, the part of the archinephric duct closest to the testis is coiled up to form an epididymis. Below this are a number of small glands secreting components of the seminal fluid. The final portion of the duct also receives ducts from the kidneys in most species. In amniotes, however, the archinephric duct has become a true vas deferens, and is used only for conducting sperm, never urine. As in cartilaginous fish, the upper part of the duct forms the epididymis. In many species, the vas deferens ends in a small sac for storing sperm. The only vertebrates to lack any structure resembling a vas deferens are the primitive jawless fishes, which release sperm directly into the body cavity, and then into the surrounding water through a simple opening in the body wall.
The outer epithelial layer of the skin that is superficial to the dermis.
A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO]
The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO]
relationship loss: subclass external integument structures (AAO:0000961)[AAO]
(...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG]
Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes).
Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.
Connective tissue in which fat is stored.[TAO]
Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO]
relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]
Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG]
In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen.
in FMA this is dense irregular connective tissue
A subdivision of the muscular system corresponding to a subdisivision of an organism.
In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here.
The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].
A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]
Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]
Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
The brain and spinal cord. Kimmel et al, 1995.[TAO]
The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO).
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]
A group of axons linking two or more neuropils and having a common origin, termination[FBbt].
White matter structure of CNS that contains axons that arise predominantly in one central nervous system part and terminate in another. Tracts are generally named by their region or origin followed by their region of primary termination, e.g., mammillothalamic tract contains axons that arise from neurons in the mammillary bodies and terminate in the thalamus. (CUMBO)
WP says this is the analog of peripheral nerves in CNS.
An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.
A portion of tissue which is a fasiculated group of axons.[TAO]
A joint that binds the teeth to the alveolar ridge.
Specifically, the connection is made between the maxillary or mandible to the cementum of the tooth. The motion of a gomphosis is very minimal, though considerable movement can be achieved over time--the basis of using braces to realign teeth. The joint can be considered a synarthrosis or an amphiarthrosis. The gomphosis is the only joint-type in which a bone does not join another bone, as teeth are not technically bone. In modern, more anatomical, joint classification, the gomphosis is simply considered a fibrous joint because the tissue linking the structures is ligamentous[WP]
MA classifies this as a cartilaginous joint
A filament, mostly protein, that grows from follicles found in the dermis[WP].
TODO for now we treat vibrissa/whisker as a syonym, but these have different follicles. We could introduce subclasses (see also: Pangolin scales)
A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP].
One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG]
the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells
In therians, a structure homologous to the yolk sac is is present, but contains no yolk platelets. Instead it is filled with fluid [ISBN:0073040584 (Vertebrates, Kardong)]
A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED].
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNYX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx)[MESH:A03.867].
Anatomical cavity bounded by the derivatives of the branchial arches.[AAO]
Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO]
Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills[ZFA:0000056, ZFIN:ZDB-PUB-961014-576].
The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO]
relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO]
(...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG]
MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme
Consider generalizing to deuterostome pharynx
Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).
Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]
The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]
esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)
Saliva-secreting exocrine glands of the oral cavity[GO].
currently we define saliva and salivary glands very generally in functional terms but it may be more appropriate to split this class. From WP: In most vertebrates, saliva does not contain any enzymes, consisting of mucus and water only, and its primary function is to moisten food while eating. As a result, true salivary glands are rarely found in fish or aquatic tetrapods, although there are often individual mucus-secreting cells. Amphibians have a single salivary gland, the intermaxillary gland, located in the forward part of the palate. Reptiles and birds normally have only very small glands on the lips, palate, and base of the mouth, although there are some birds with large glands, which produce a sticky saliva that helps in nest-building. The distinct parotid, submandibular, and sublingual glands are only developed in mammals.
A gland that produces the saliva. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-25, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]
In air-feeding animals, the lack of water column to lubricate the food has been compensated for by the evolution of the salivary glands. These glands are present only in amniotes and are controlled by the parasympathetic system.[well established][VHOG]
The salivary glands in mammals are exocrine glands, glands with ducts, that produce saliva. They also secrete amylase, an enzyme that breaks down starch into maltose. In other organisms such as insects, salivary glands are often used to produce biologically important proteins like silk or glues, and fly salivary glands contain polytene chromosomes that have been useful in genetic research. The salivary glands of some species are modified to produce enzymes; salivary amylase is found in many, but by no means all, bird and mammal species (including humans, as noted above). Furthermore, the venom glands of poisonous snakes, Gila monsters, and some shrews, are modified salivary glands
The terminal portion of the intestinal tube, terminating with the anus.
The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html
Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice.
The lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region.
The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted].
Portion of the liver which develops on the fish's left side.[TAO]
Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO].
Note that in contrast to VSAO, this is a subset of the skeletal system, and thus includes intervertebral joints, cartilage and ligaments etc. Some ontologies such as AAO seem to purely refer to the skeleton
Anatomical cluster that consists of all the vertebra in the body.[VSAO]
The vertebral column consists of a series of vertebrae connected by ligaments. It provides a supporting axis for the body and protects the spinal cord. [TFD][VHOG]
Vertebrata is characterized by three synapomorphies. First, vertebrates have a backbone composed of vertebrae (...).[well established][VHOG]
Muscle tissue that consists primarily of skeletal muscle fibers.
TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle.
Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]
Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]
This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG]
Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).
A large triangular surface of the liver devoid of peritoneal covering.
A pouch in the digestive tract that connects the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve, and is the beginning of the large intestine. It is also separated from the colon by the cecocolic junction.
A cecum is present in most amniote species, and also in lungfish, but not in any living species of amphibian. In reptiles, it is usually a single median structure, arising from the dorsal side of the large intestine. Birds typically have two paired ceca, as, unlike other mammals, do hyraxes. Most mammalian herbivores have a relatively large cecum, hosting a large number of bacteria, which aid in the enzymatic breakdown of plant materials such as cellulose; in many species, it is considerably wider than the colon. In contrast, obligatory carnivores, whose diets contain little or no plant material, have a reduced cecum, which is often partially or wholly replaced by the vermiform appendix. Many fish have a number of small outpocketings, called pyloric ceca, along their intestine; despite the name they are not homologous with the cecum of amniotes, and their purpose is to increase the overall area of the digestive epithelium.[2] Some invertebrates, such as squid,[3] may also have structures with the same name, but these have no relationship with those of vertebrates.
Taxon notes: in some herbivorous lizards, a cecum is present between small and large intestines[Kardong]
A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal.
Some references do not consider the caecum to be part of the colon.
TODO - abstract this such that it legitimately covers all vertebrates
The last portion of the digestive system, it extracts water and salt from solid wastes before they are eliminated from the body.[AAO]
The posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates. Wallace et al, 2005.[TAO]
Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]
In mammals, the colon consists of four sections: the ascending colon, the transverse colon, the descending colon, and the sigmoid colon[WP]
In zebrafish, the posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates[ZFIN]
it extracts water and salt from solid wastes before they are eliminated from the body[WP]
The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP].
The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted].
An ureter that is part of a right side of organism [Automatically generated definition].
Outer cortical portion of the kidney, between the renal capsule and the renal medulla.
In the adult metanephros, it forms a continuous smooth outer zone with a number of projections that extend down between the pyramids. It contains the renal corpuscles and the renal tubules except for parts of the loop of Henle which descend into the renal medulla. It also contains blood vessels and cortical collecting ducts. The renal cortex is the part of the kidney where ultrafiltration occurs.[WP]
A cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus.
Anatomical structure found in the kidney consisting of an expanded end of a kidney tubule surrounding a glomerulus and is the major site of filtration.[AAO]
Fluids from blood in the glomerulus are collected in the Bowman's capsule and further processed along the nephron to form urine. This process is known as ultrafiltration[WP].
One fold of the S-shaped body gives rise to Bowman's capsule[GUDMAP]
An epithelial tube that is part of the nephron, the functional part of the kidney.
note that in ISBN:0073040584 (Vertebrates, Kardong), the uriniferous tubule contains the nephron, so we have a separate class, rather than using a synonym, as in MA
The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient.
Renal duct that collects the output from renal tubules.[TAO]
in ISBN:0073040584 (Vertebrates, Kardong), the nephron is adjacent to the collecting tubule, consistent with FMA, but not GO. Wikipedia says: Many sources include the connecting tubule as part of the collecting duct system. However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron
The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone.
All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]
Kardong states that mammals are the first to have distinct cortext and medulla, but this contradicts XAO
Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts.
opening of terminal part of digestive tract
Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].
A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]
Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO]
In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG]
The urinary bladder evolved in tetrapods. Birds to not possess a true urinary bladder, although Palaeognathae have an undifferentiated cloacal outpocketing that serves a similar function[https://github.com/obophenotype/uberon/issues/454]
An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO].
Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]
In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]
As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52)
The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract. The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm
The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans
Transudate contained in the peritoneal cavity.
The acetabulum is a concave surface of the pelvis. The head of the femur meets with the pelvis at the acetabulum, forming the hip joint. There are three bones of the os coxae (hip bone) that come together to form the acetabulum. Contributing a little more than two-fifths of the structure is the ischium, which provides lower and side boundaries to the acetabulum. The ilium forms the upper boundary, providing a little less than two-fifths of the structure of the acetabulum. The rest is formed by the pubis, near the midline. It is bounded by a prominent uneven rim, which is thick and strong above, and serves for the attachment of the acetabular labrum, which reduces its opening, and deepens the surface for formation of the hip joint. At the lower part of the acetabulum is the acetabular notch, which is continuous with a circular depression, the acetabular fossa, at the bottom of the cavity of the acetabulum. The rest of the acetabulum is formed by a curved, crescent-moon shaped surface, the lunate surface, where the joint is made with the head of the femur. Its counterpart in the pectoral girdle is the glenoid fossa.[WP,unvetted].
Cavity for the articulation of the proximal bone of the hind limb.[AAO]
During the transformation from the osteolepiform fins to tetrapod limbs, the appendages and girdles underwent a number of radical changes. The pelvic girdle became a weight-bearing structure by evolution of an ischium, a full mesio-ventral contact between the two sides of the girdle, an ilium, and a contact between the vertebral column and the girdle through a sacral rib. Fore- and hindlimbs shifted laterally by reorientation of the glenoid and the acetabulum.[well established][VHOG]
In reptiles and in birds, the acetabula are deep sockets.
whilst WP defines this as a surface, MA treats it as a bone. There are other FMA classes that may be better suited to representing the surface.
Endochondral bone that is paired, forming the posterior part of the pelvis, articulating with the pubis and ilium.
Paired bones of endochondral origin that constitute the posterior elements of the pelvic girdle. They are synostotically fused to each other and form the posterior part of the acetabulum.[AAO]
this is_a hip bone in MA; in FMA it is a zone of bone organ.
Epithelial layer that lines the intestine.
Simple columnar epithelium that lines the intestine, sometimes pseudostratified, with absorptive brush-border cells and mucous goblet cells clearly visible. Crosnier et al. 2005[TAO]
The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy.
The mucous membrane lining the uterus. [TFD][VHOG]
The maternal part of the placenta (of eutherian mammals) is the vascularized and glandular uterine lining, or endometrium.[well established][VHOG]
Animals that have estrous cycles reabsorb the endometrium if conception does not occur during that cycle. Animals that have menstrual cycles shed the endometrium through menstruation instead
in FMA this is subdivided into basal and outer
The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted].
todo - compare with EHDAA2. Check embryonic vs extraembryonic, developmental relationships
A retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect.
The outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae.
MP distinguishes compact/cortical bone. in other AOs they are syns
A bone that is part of the tarsal skeleton. Examples: calcaneus, talus, centralia.
In primitive tetrapods, such as Trematops, the tarsus consists of three rows of bones. There are three proximal tarsals, the tibiale, intermedium, and fibulare, named for their points of articulation with the bones of the lower limb. These are followed by a second row of four bones, referred to as the centralia (singular: centrale), and then a row of five distal tarsals, each articulating with a single metatarsal. In the great majority of tetrapods, including all of those alive today, this simple pattern is modified by the loss and fusion of various of the bones.[3] In reptiles and mammals, there are normally just two proximal tarsals, the calcaneus (equivalent to the amphibian fibulare) and the talus (probably derived from a fusion of multiple bones). In mammals, including humans, the talus forms a hinge joint with the tibia, a feature especially well developed in the artiodactyls. The calcaneus is also modified, forming a heel for the attachment of the Achilles tendon. Neither of these adaptations is found in reptiles, which have a relatively simple structure to both bones.[3] The fifth distal tarsal disappears relatively early in evolution, with the remainder becoming the cuneiform and cuboid bones. Reptiles usually retain two centralia, while mammals typically have only one (the navicular).[3] In birds, the tarsus has disappeared, with the proximal tarsals having fused with the tibia, the centralia having disappeared, and the distal bones having fused with the metatarsals to form a single tarsometatarsus bone, effectively giving the leg a third segment
Endochondral tarsal bone articulating with centralia and metatarsal 1.
Small element that articulates with the prehallux, metatarsal I and element Y. It may be fused to tarsal 2.[AAO]
A zone of skin that is part of a external ear [Automatically generated definition].
zone of skin of auricular region of head
The part of the forelimb extending from the shoulder to the autopod[cjm].
currently declared as overlapping hand, as AOs disagree over whether some wrist parts are in the arm or hand
this class refers to the combination of the stylopod and zeugopod of a forelimb. Sometimes (cf FMA), 'arm' denotes the stylopod only; sometimes (cf MA), 'arm' denotes the part of the forelimb covering both (i.e. shoulder to hand). Also note distinction between arm and forelimb: hand is part of forelimb, but not part of arm
The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified].
The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG]
See notes for shoulder. in BTO this is part of the abdomen - this creates an inconsistency if limb and abdomen are spatially disjoint
A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle).
(...) endochondral elements of the early tetrapod shoulder develop from two centers of ossification, giving rise to a scapula and a 'coracoid'.[well established][VHOG]
In FMA, the shoulder is part of the pectoral girdle region. in MA, shoulder structures like shoulder joints, bones, nerves etc are part of the shoulder and the forelimb. E.g. humerus is a shoulder bone
Skeletal element that is composed of bone tissue.
Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]
Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO]
Skeletal element that is composed of bone tissue.[VSAO]
The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG]
The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.
Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted].
Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates
The lymph nodes located in the groin area.
A branch of the lingual artery that supplies the sublingual gland.
Check grouping with amphibian structure of the same name
Part of the external carotid which supplies blood to the tip of the snout where branches go to the tongue and the m. geniohyoideus.[AAO]
relationship loss: part_of external carotid (AAO:0010218)[AAO]
A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins.
placement of the ZFA class here is dubious
Lymphatic trunk that connects all tributaries of the thoracic duct tree to the trunk of the left brachiocephalic vein.
The thoracic duct is the first perfused lymphatic, located between the dorsal aorta and posterior cardinal vein.
An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].
Note that in FMA an artery is a tree, whereas AEO/JB defines it as a tube; FMA includes a separate class for what it calls the trunk. Classification in this ontology may currently (Jan 2012) represent a mix of both schemes, although we are gradually revising in the direction of the AEO scheme.
Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO]
The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]
Some arthropods have primitive arterial systems but this term refers to arteries in a true closed circulatory system.
Any of the tubular branching vessels that carry blood from the capillaries toward the heart.
TODO - check with MA - vein vs venous blood vessel
Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO]
The supraorbital vein begins on the forehead where it communicates with the frontal branch of the superficial temporal vein. It runs downward superficial to the Frontalis muscle, and joins the frontal vein at the medial angle of the orbit to form the angular vein. Previous to its junction with the frontal vein, it sends through the supraorbital notch into the orbit a branch which communicates with the ophthalmic vein; as this vessel passes through the notch, it receives the frontal diploic vein through a foramen at the bottom of the notch. The areas drained by this vessel are the forehead, eyebrow and upper eyelid. [WP,unvetted].
Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
The organ of hearing and of equilibrium. [TFD][VHOG]
Both vertebrate and invertebrate auditory organs are thought to have evolved from primitive mechanosensors, but the nature of the ancestral structure and the evolutionary trajectories followed in distinct animal lineages remain unknown. In particular, we do not know how many types of mechanosensor existed in the protostome-deuterostome ancestor from which insects and vertebrates evolved or whether the PDA had an auditory organ.[well established][VHOG]
A bone which is fused with the temporal bone in many mammals and forms part of the cheek region articulating with quadrate and pterygoid in other vertebrates.
consider separate class for squamosal OR making squamosal the primary label
Paired, intramembranous bones that lie at the posterolateral margins of the skull. Lateral and dorsal to the quadrate.[AAO]
The squamosal bone is part of the dermatocranium in early tetrapods and becomes part of the mammalian occipital and temporal bones. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, p.246, see_Liem_KF][VHOG]
The squamosal bone, which is homologous with the squama, and forms the side of the cranium in many bony fish and tetrapods. Primitively, it is a flattened plate-like bone, but in many animals it is narrower in form, for example, where it forms the boundary between the two temporal fenestrae of diapsid reptiles
The nasal septum separates the left and right airways in the nose, dividing the two nostrils. It is depressed by the Depressor septi nasi muscle. [WP,unvetted].
We follow AAO in making this part of the nasal skeleton
A median dividing wall, sagittally directed, which divides the nasal cavity into the right and the left nasal fossae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
Medial vertical wall between nasal capsules.[AAO]
Medial, vertical plate that separates the nasal capsules.[AAO]
Whatever the common ancestor of the lamprey and gnathostomes may have looked like, it most likely possessed a neural-crest-derived premandibular ectomesenchyme closely associated with the NHP. Invention of the jaw subsequently required a space for the nasal septum and maxillary process to develop, which might have been provided by subdivision of the NHP into the nasal placode and the hypophysis (diplorhiny, the state of bilaterally separated nasal openings, would also have been a prerequisite for this).[well established][VHOG]
The part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences.
present in mammals and some reptiles. A similar structure is found in crocodilians, but, in most other tetrapods, the oral and nasal cavities are not truly separate. The secondary palate is formed by bilateral medial extensions of maxillary processes. The extensions (palatine processes) meet at the midline, merging dorsally with nasal septum and rostrally with primary palate. The secondary palate (hard palate) separates nasal and oral cavities. Caudal extension of the secondary palate into the pharynx, forms a soft palate which divides the rostral pharynx into dorsal (nasopharynx) and ventral (oropharynx) chamber.
A muscular organ in the floor of the mouth.
in MA the tongue is part of the oral region, which in uberon is treated as the oral opening. consider revising oral opening - oral region equivalence.
A mobile mass of muscular tissue that is covered with mucous membrane, occupies much of the cavity of the mouth, forms part of its floor, bears the organ of taste, and assists in chewing and swallowing. [TFD][VHOG]
Muscular organ in the floor of the mouth.[FEED]
The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech[GO][GO:0043586].
Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]
Many species of fish have small folds at the base of their mouths that might informally be called tongues, but they lack a muscular structure like the true tongues found in most tetrapods
The tongue has contributions from all pharyngeal arches which changes with time. The tongue initially begins as swelling rostral to foramen cecum, the median tongue bud.. tongue muscles derive from the somites - http://php.med.unsw.edu.au/embryology/index.php?title=Tongue_Development#Pharyngeal_Arch_Contributions
The muscular, non-bony arch-shaped posterior portion of the palate extending from the posterior edge of the hard palate.
A muscular arch-shaped structure that is composed of the musculus uvuli and parts of tensor veli palatini, levator veli palatini, palatoglossus and palatopharyngeus and attaches to the hard palate and modulates the connections between the oral cavity and pharynx soft tissue arch .[FEED]
Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible.
Either of two major salivary glands situated in the neck near the lower edge of each side of the mandible and emptying into the submandibular duct. [TFD][VHOG]
The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]
In humans, they account for 70% of the salivary volume and weigh about 15 grams. [WP,unvetted]
In mouse, multilobed and lobulated, on the ventral midline of the neck
in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty[MGI:anna]
The submandibular is the first major salivary gland to develop in the embryo, followed by the neighbouring sublingual and then the parotid.[PMID:17336109]
The term submandibular as used in humans, is incorrect due the difference in topography of these structures[http://www.avdc.org]
A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.
An anatomical cluster consisting of the epiglottus, the arytenoid cartilages, the thyroid cartilage, the cricoid cartilage and the muscles, membranes, and ligaments connecting them, and also of the mucosal covering these structures.[FEED]
Anatomical structure consisting of a narrowly triangular chamber supported by a series of semicircular cartilages in which part of the sound-production system is located.[AAO]
(In anura) a dorsal pair of arytenoid cartilages (...), which support vocal cords, and a ventral pair (often fused) of cricoid cartilage (...). These cartilages are regarded as derivatives of posterior visceral arches of ancestors. Together they constitute the larynx, a structure characteristic of tetrapods. (...) (In mammals) Paired arytenoid cartilages help support and control the vocal cords. The cricoid cartilage is single. Two additional cartilages are present that are lacking in other vertebrates: a large ventral thyroid cartilage (...) and a cartilage in the epiglottis.[well established][VHOG]
Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP].
The small curved bones that extends horizontally along the lateral wall of the nasal passage.
In humans, the turbinates divide the nasal airway into three groove-like air passages -and are responsible for forcing inhaled air to flow in a steady, regular pattern around the largest possible surface of cilia and climate controlling tissue.
Turbinals are only ossified in birds and derived synapsids.
FMA considers nasal concha and nasal concha of ethmoid bone to be synonymous. We disambiguate these here
Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].
check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA
MP treats posterior uvea and optic choroid as distinct
The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball.
A nerve plexus that is part of an autonomic nervous system [Automatically generated definition].
The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001].
FMA has a 3-level breakdown of jaws into: region, jaw (skeleton+gums), skeleton.
One of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands.
There are 3 pairs of major salivary glands in human and mouse
The parotid gland is the largest of the salivary glands. It is found wrapped around the mandibular ramus, and it secretes saliva through Stensen's duct into the oral cavity, to facilitate mastication and swallowing. [WP,unvetted].
A mammalian salivary gland located caudal to the ear. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-22, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]
The mouse parotid, exorbital lacrimal gland and exocrine pancreas have similar histological appearances[ISBN:0123813611]
this class is used more generically than in FMA, and includes e.g. cortex of hair
A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces.
TODO - check relationship to ventricle. Check subclass - ZFA says vasculature. Note that FMA:61934 (choroid plexus of cerebral hemisphere) has exact synonym 'choroid plexus' but it is not clear that this belongs here, as the fourth ventricle is not in the cerebral hemisphere
A tuft of capillaries that project into the ventricles of the brain and secretes cerebral spinal fluid. The choroid plexus is covered by a cuboidal epithelium which maintains the integrity of the blood-brain barrier.[TAO]
Fringe of the tela choroidea of the brain ventricles[MP]
The division of the forebrain that develops from the foremost primary cerebral vesicle.
The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO]
Unpaired part of the forebrain comprised of three major parts; the epithalamus, thalamus, and hypothalamus.[AAO]
Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]
An epithelium that is part of a small intestine [Automatically generated definition].
Intestinal epithelium which lines the lumen of the mid intestine.[TAO]
A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males.
Originally this was classified as a female reproductive structure, as it was in the MP in 2011
Any of the milk-producing apocrine glands typically occurring in pairs in female mammals and consisting of lobes containing clusters of alveoli with a system of ducts to convey the milk to an external nipple or teat. [TFD][VHOG]
The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]
A mouse mammary gland contains a single duct or sinus, forming 5-10 secondary ducts
The male Dayak fruit bat has lactating mammary glands
The mammary glands of humans are in the thoracid/breast region. In other mammals they may be located elsewhere on the mammary ridges.
The BTO class represents the combination of nipple plus lobe
The FMA class represents an individule lobe. The nipple is not a part
The MA class represents a composite structure, including the nipple, fat, connective tissue, smooth muscle as parts
An endothelium that is part of an artery [Automatically generated definition].
The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO]
Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]
An endothelium that is part of a vein [Automatically generated definition].
A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO].
In humans: 15% orthokeratinized, 75% parakeratinized, 10% non-keratinized; diurnal; decreased keratinization with age. Note that in FMA this is classified as keratinized squamous - this perhaps refers to the epithelium of the attached or free gingiva
A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum.
Non-mammalian species do not have a brain structure that looks like the mammalian hippocampus, but they have one that is considered homologous to it. The hippocampus, as pointed out above, is essentially the medial edge of the cortex. Only mammals have a fully developed cortex, but the structure it evolved from, called the pallium, is present in all vertebrates, even the most primitive ones such as the lamprey or hagfish. The pallium is usually divided into three zones: medial, lateral, and dorsal. The medial pallium forms the precursor of the hippocampus. It does not resemble the hippocampus visually, because the layers are not warped into an S shape or enwrapped by the dentate gyrus, but the homology is indicated by strong chemical and functional affinities. There is now evidence that these hippocampal-like structures are involved in spatial cognition in birds, reptiles, and fish. In birds, the correspondence is sufficiently well established that most anatomists refer to the medial pallial zone as the 'avian hippocampus'. The story for fish is more complex. In teleost fish (which make up the great majority of existing species), the forebrain is distorted in comparison to other types of vertebrates: most neuroanatomists believe that the teleost forebrain is essentially everted, like a sock turned inside-out, so that structures that lie in the interior, next to the ventricles, for most vertebrates, are found on the outside in teleost fish, and vice versa. One of the consequences of this is that the medial pallium ('hippocampal' zone) of a typical vertebrate is thought to correspond to the lateral pallium of a typical fish. Several types of fish (particularly goldfish) have been shown experimentally to have strong spatial memory abilities, even forming 'cognitive maps' of the areas they inhabit.[WP]
A vessel through which blood circulates in the body.
consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus
Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]
Any of the vessels through which blood circulates in the body.[AAO]
annelids have blood vessels, but this class is not applicable to annelids.
FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX
A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].
The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980)
Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell.
Phylogenetic analyses of the concatenated data set using maximum parsimony, maximum likelihood and distance based (neighbour joining) methods all converged on a nearly identical, well supported topology defining four principal eutherian lineages. The results affirm monophyly of traditional placental orders (except Artiodactyla and Insectivora), and also support some previously proposed, as well as new, superordinal clades.[well established][VHOG]
Eutherians: In eutherians, the chorioallantoic membrane of the fetus establishes intimate contact with the adjacent vascular wall of the mother's uterus to produce the placenta, a composite structure formed in part from tissues of the fetus and in part from tissues of the mother [ISBN:0073040584 (Vertebrates, Kardong)]. TODO - is taxon restriction too strict, even if we restrict def to allantoic placenta? - WP says: also found in some snakes and lizards with varying levels of development up to mammalian levels. Pough et al. 1992. Herpetology: Third Edition. Pearson Prentice Hall:Pearson Education, Inc., 2002. // See also: DOI:10.1002/jmor.11011
Marsupials possess only a rudimentary yolk-type placenta, with reduced nutrient and oxygen exchanging capabilities.
The upper layer of the dermis beneath the epidermis, composed of dense irregular connective tissue[ncit,modified].
Dense irregular connective tissue of the skin that consists of fibroblasts, various connective tissue cell types, and collagen, predominantly type III.
The pulmonary plexus is an autonomic plexus formed from pulmonary branches of vagus nerve and the sympathetic trunk that supplies the Bronchial tree. [WP,modified].
An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood..
Major artery which supplies blood to the lungs.[AAO]
One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG]
On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]
In the human heart, the pulmonary trunk (pulmonary artery or main pulmonary artery) begins at the base of the right ventricle. It is short and wide - approximately 5 cm (2 inches) in length and 3 cm (1.2 inches) in diameter. It then branches into two pulmonary arteries (left and right), which deliver deoxygenated blood to the corresponding lung[WP]
Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO].
Any of the veins which collect blood from the lungs and some small vesicles received from the esophagus.[AAO]
One of two pairs of large vessels that return oxygenated blood from each lung to the left atrium of the heart. [TFD][VHOG]
the veins that return oxygenated blood from the lungs to the left atrium of the heart
Soft tissue that lines the non-cartilaginous surfaces within joints with cavities (synovial joints).
Phylogenetically, synovium is one of the newer attributes of the vertebrate locomotor apparatus. The first synovial joints developed in the piscine jaw of ancestors of modern lungfish by an evolutionary process that modified preexisting fibrous and cartilaginous joints, which were the predominant articulation of the early sea- and land-dwelling vertebrates.[well established][VHOG]
membrana synovialis (capsula articularis)
membrana synovialis capsulae articularis
synovial layer of articular capsule of synovial joint
synovial membrane of articular capsule of synovial joint
synovium of articular capsule of synovial joint
Projection of skin containing the outlets for 15-20 lactiferous ducts arranged cylindrically around the tip.
a male mouse has no nipples - mammary tissue regresses during embryonic development
FMA makes this part of the breast, whereas in MA it is part of the mammary gland -
Nipple being part_of mammary gland is due to a practical modelling in uberon that treats mammary gland as including adnexa. A GCI asserts that nipple is part of the breast in humans. For discussion of this, please refer to https://github.com/obophenotype/uberon/issues/1873.
Muscle tissue that contains fibers that are divided by transverse bands into striations.
Voluntary muscle tissue arranged in bundles of fibers.[AAO]
Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA].
Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO]
Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO]
However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG]
The absence of a cerebellum in hagfishes and lampreys appears to be the only exception [to the rule that vertebrates possess the same number of brain divisions]. Both hagfishes and lampreys do possess a thin band of cells located medial to the lateral line centers of the medulla (Ronan and Northcutt, 1998), which has been interpreted as a primitive cerebellum (Larsell, 1967), but more recent experimental studies (Kishida et al., 1987; Weigle and Northcutt, 1998) fail to support Larsell's claim[http://icb.oxfordjournals.org/content/42/4/743.full]
almost all AOs agree that the cerebellum is part of the hindbrain (sometimes specifically part of the metencephalon, which, when present, is part of the hindbrain). However, ABA has cerebellum and brain stem as partof siblings, with the hindbrain part of the brainstem
A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO].
Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (2) a groove in the pharyngeal floor known as the endostyle, or a thyroid gland derived from part of the endostyle (...).[well established][VHOG]
In fish, it is usually located below the gills and is not always divided into distinct lobes. However, in some teleosts, patches of thyroid tissue are found elsewhere in the body, associated with the kidneys, spleen, heart, or eyes
In larval lampreys, the thyroid originates as an exocrine gland, secreting its hormones into the gut, and associated with the larva's filter-feeding apparatus. In the adult lamprey, the gland separates from the gut, and becomes endocrine, but this path of development may reflect the evolutionary origin of the thyroid. For instance, the closest living relatives of vertebrates, the tunicates and Amphioxus, have a structure very similar to that of larval lampreys, and this also secretes iodine-containing compounds (albeit not thyroxine)
In tetrapods, the thyroid is always found somewhere in the neck region. In most tetrapod species, there are two paired thyroid glands - that is, the right and left lobes are not joined together. However, there is only ever a single thyroid gland in most mammals, and the shape found in humans is common to many other species
Respiration organ that develops as an outpocketing of the esophagus.
Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO]
Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG]
respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi
Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]
An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.
see also: vascular system. Consider merging?
The femoral artery is a large artery in the muscles of the thigh. It is a continuation of external iliac artery where it enters the femoral triangle at the mid inguinal point behind the inguinal ligament. It leaves femoral triangle through apex beneath the sartorius muscle. It enters the popliteal fossa by passing through the 5th osseo-aponeurotic(adductor hiatus) opening of adductor magnus where it becomes the Popliteal Artery. [WP,unvetted].
Artery which supplies blood via branches to the hindlimbs.[AAO]
The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. [WP,unvetted].
The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].
Consider adding a layer-of-skin grouping class for all skin layers
A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]
When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]
Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].
A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]
A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544].
BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument.
An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.
An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO]
general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs.
Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon.
in Uberon, this term is used in the generic sense, not necessarily restricted to the peritoneum, consistent with FMA. WP: 'In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.'. TODO - check. Consider FMA:259286 - Region of mesentery.
The organ covering the body that consists of the dermis and epidermis.
consider 'integumentary system' for invertebrates
MA uses the term skin to refer to what is called here: zone of skin
Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.
Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO]
Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO]
The organ that functions to filter blood and to store red corpuscles and platelets.
An organ involved in red blood cell filtration and immune response.[AAO]
With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]
In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron
Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96)
It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells
An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
Organ which secretes bile and participates in formation of certain blood proteins.[AAO]
relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]
All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]
An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003).
The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates.
secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function.
Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong].
The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO]
A paired organ of the urinary tract that produces urine and maintains bodily fluid homeostasis, blood pressure, pH levels, red blood cell production and skeleton mineralization.
One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO]
The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).
The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum.
In humans, the duodenum is a hollow jointed tube about 10-15 inches (25-38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz.
The portion of the small intestine that extends from the duodenum to the ileum.
TODO consider ZFA:0001323 mid intestine, see also small intestine
The first two fifth of the small intestine beyond the duodenum. It extends from the end of the duodenum to the ileum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
The jejunum is the middle section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms middle intestine or mid-gut may be used instead of jejunum.[Wikipedia:Jejunum]
The portion of the small intestine that extends from the jejunum to the colon.
TODO consider ZFA:0000706 posterior intestine, see also colon
The ileum is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine may be used instead of ileum.[Wikipedia:Ileum]
In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO].
A kidney formed of nephric tubules arising in the anterior region of the nephric ridge; forms only as a transient embryonic structure. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.748][VHOG]
Organ that serves as a transient kidney, providing osmoregulation during early developmental stages and then degenerating during metamorphosis.[AAO]
The embryonic kidney, present at the level of the third somite, is composed of two glomeruli fused at the midline, two pronephric tubules, and paired bilateral pronephric ducts that modify the composition of the blood filtrate before delivering it to the cloaca for excretion.Kimmel et al, 1995.[TAO]
In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]
Once the more complex mesonephros forms the pronephros undergoes apoptosis in amphibians. In fishes the nephron degenerates but the organ remains and becomes a component of the immune system[Wikipedia:Pronephros]. // TODO - check developmental relationships. Note that we previously include the ZFA/XAO terms under the more specific 'pronephric kidney', but these are now merged. TODO GCI: relationship: capable_of GO:0030104
The upper conducting airways of the lung; these airways arise from the terminus of the trachea.
Each of the two primary divisions of the trachea leading respectively into the right and the left lung. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
In humans, the main bronchus is histologically identical to trachea; 2ary and 3ary bronchi are not; epithelium becomes simple columnar, goblet cell number decreases, elastic fibers in lamina propria increases, distribution more uniform. Muscular layer between mucosa and submucosa appears. cartilage rings become discontinuous plates connected by fibrous connective tissue
The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching.
lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer
In FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however, there are two distinct terms for the corresponding epithelium.
In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole.
A portion of adipose tissue that is part of the hypodermis, beneath the dermis.
the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156]
Vasculature that is part of the eye region.
not part of the eye in ZFA. Note this changed to a blood vessel in ZFA
An intersegmental rod-shaped bone that forms in the peritoneal membrane and attach to the vertebral parapophyses.
Endochondral bone that is intersegmental and rod-shaped, forming in the peritoneal membrane and attached to the vertebral parapophyses. Ribs protect and support internal organs.[TAO]
Endochondral, rodlike element that articulates with the transverse process and parapophysis (double-headed rib), or with the transverse process only (single-headed rib); it extends into the body wall and provides a site for muscle attachment.[AAO]
In most vertebrates, ribs surround the chest. In some species, especially snakes, ribs may provide support and protection for the entire body
They protect and support internal organs and enable lungs to expand by expanding the chest.
A rib that is not connected to sternum or sternal cartilage.
We synonymize 'free rib' with 'floating rib' - this case it referes to caudal ribs, but you can have free ribs (i.e. non-attached ventrally) in other places . Should we just synonymize this with 'floating rib'? see Primate Anatomy: An Introduction by Friderun Ankel-Simons pg. 275
Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).
TODO - add superclass to unify with VNC?
Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO]
The connecting cord from the developing embryo to the placenta.
The connecting cord from the developing embryo or fetus to the placenta. During prenatal development, the umbilical cord comes from the same zygote as the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta.property_value, external_definition the umbilical arteries return the deoxygenated, nutrient-depleted blood[WP].
The middle layer of the heart, comprised mainly of striated cardiac muscle fibers.
Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
The middle layer of the heart, consisting of cardiac muscle.[AAO]
EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium
The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA].
WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node.
The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs.
MA and FMA differ in what they consider to be parts of the pelvis. MA includes ureter, urethra, urinary bladder, reproductive organs
A serous membrane that lines the peritoneal cavity[VHOG,modified].
An epithelium that lines the peritoneal cavity.[TAO]
Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO]
A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas.
Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses
The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
TODO - FMA treats the gland as part of the prostate - see also FMA:74119.
Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].
Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO].
Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO]
All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]
The origin of the adrenal gland is still controversial. It is thought to share the same origin as the kidney and gonads, derived from coelomic epithelium of the urogenital ridge and/or the underlying mesenchyme (Keegan and Hammer, 2002; Morohashi, 1997). We follow Kardong and state homology at the level of the cortex and medulla rather than gland as a whole
suprarenal cortex manufactures corticosteroids; suprarenal medulla manufactures epinephrine and norepinephrine; suprarenal medulla receives preganglionic sympathetic innervation from the greater thoracic splanchnic n.
Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop.
check - a subtype of gland? not in GO. NCIT has thymus and thymus gland. EHDAA2 has ductless gland.
Anatomical structure which originates as several paired thickenings on the dorsal side of the pharyngeal pouches and secretes thymosin.[AAO]
A thymus develops in all vertebrates from the endodermal epithelium of certain pharyngeal pouches and from the adjacent ectodermal epithelium. In fishes, all the pouches, or the first four, contribute to thymus formation, but in tetrapods, the number is more restricted. In mammals, only the third and fourth are involved, and the contribution of the third is by far the greater.[well established][VHOG]
The soft tissue that fills the cavities of bones.
TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs
consider placement of NCIT:C53466 medullary bone
The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]
In adults, marrow in large bones produces new blood cells[Wikipedia:Bone_marrow]
Either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx.
the term 'tonsil' can be ambiguous, sometimes refering specifically to the palatine tonsil, sometimes generically to include the cecal tonsils of avians. This class represents lymphoid tissue that is part of the tonsillar ring, in the mouth/throat region
Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.
One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO]
Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO]
Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO]
Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].
One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO]
Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach.
Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP].
Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine.
A duct that carries bile from the liver to the intestine.
Any of the excretory ducts in the liver that convey bile between the liver and the intestine. [TFD][VHOG]
(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]
we place the ZFA class here as this fits its textual definition and child nodes. We may recommend a label change for ZFA
The bone which normally forms the lateral upper jaw in osteichthyans, including tetrapods.
Dermal bone that forms part of the upper jaw, located antero-ventral to the premaxilla. The maxilla is a paired bone.[TAO]
Paired, intramembranous bone located on the lateral sides of the skull, posterior to the premaxillae.[AAO]
relationship loss: overlaps autopalatine-maxillary joint (TAO:0001942)[TAO]
relationship loss: overlaps premaxillary-maxillary joint (TAO:0002260)[TAO]
In some teleosts, the maxilla is located postero-ventral to the supramaxilla. Commonly, the articular process of the maxilla articulates with the autopalatine and ethmoidal region antero-medially. The maxilla is usually the largest bone in the upper jaw assemblage.[TAO]
The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs.
Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura].
The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium.
Peritoneum that surrounds the heart.[AAO]
In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity
this class denotes a combination of fibrous PC + PC sac (itself a combination of cavity, epithelium and connective tissue). Many sources use the term 'pericardium' to denote either just the serous membrane (ZFA) or the epithelium (GO)
we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium
Transudate contained in the pericardial cavity.[FMA].
An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail.
Note we also have a subclass post-anal tail, for the chordate specific structure. currently defined very generally, inclusive of caudal fin
Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.
A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO]
Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO]
Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO]
Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG]
Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]
An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues.
consider including separate class for developmental structure (adult human is stratified; in EHDAA2 is unilaminar)
The epithelium that lines the oral cavity. The oral epithelium epithelial cells with many short microvilli as well as mucous cells, rodlet cells and taste buds[ZFIN:ZDB-PUB-060921-12, ZFIN:ZDB-PUB-091204-24].
the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme
A bone that is part of a limb [Automatically generated definition].
the formal definition is very inclusive, and includes sesamoids
NCITA includes clavicle. MA:'limb bone' is actually a bone of limb or girdle
Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted].
One of two ganglionated neural networks which together form the enteric nervous system. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility.
plexus of unmyelinated nerve fibers and postganglionic autonomic cell bodies lying in the muscular coat of the esophagus, stomach and intestines that communicate with the submucosal, subserosal and enteric plexuses[MP][MP:0010801].
note that FMA uses Meissner's plexus as a synonym, rather than separate class
The inferior cervical ganglion is situated between the base of the transverse process of the last cervical vertebra and the neck of the first rib, on the medial side of the costocervical artery. Its form is irregular; it is larger in size than the middle cervical ganglion, and is frequently fused with the first thoracic ganglion. [WP,unvetted].
The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP].
Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]
Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]
The lymphatic system of anuran amphibians is characterized by large lymphatic sacs and two pairs of lymph hearts that return lymph into the venous circulation but no lymph vessels per se [10.1152/japplphysiol.00201.2013]
The lymphatic systems of reptiles and some birds have lymph hearts, and both groups have extensive lymph vessels, but their functional role in both lymph movement and plasma volume homeostasis is almost completely unknown [10.1152/japplphysiol.00201.2013]
We follow FMA and MA in distinguishing between lymphatic system and lymphoid system, with lymhoid tissue part of the non-lymphatic component, although these terms are often used interchangeably. We assume the ZFA term lymphatic tissue actually corresponds to the broader class (e.g. ZFA lymph node in the ZFA lymphatic system). See tracker for more comments.
Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.
see https://github.com/obophenotype/uberon/issues/27
Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO]
The opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; serves to regulate fluid pressure in the inner ear.
round window of petrous part of temporal bone
A lymph node that is part of an abdomen [Automatically generated definition].
The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group.
Replacement bone that forms within cartilage.
Replacement bone that forms within cartilage.[VSAO]
some structures, e.g. in ZFA are both intramembrane and endochondral
Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].
Bone that forms directly within mesenchyme, and does not replace other tissues.[TAO]
[In TAO], This term was made obsolete because it is considered a synonym of membrane bone (VSAO:0000023).[TAO]
The submandibular lymph nodes (submaxillary glands in older texts), three to six in number, are placed beneath the body of the mandible in the submaxillary triangle, and rest on the superficial surface of the submaxillary salivary gland. One gland, the middle gland of Stahr, which lies on the external maxillary artery as it turns over the mandible, is the most constant of the series; small lymph glands are sometimes found on the deep surface of the submaxillary salivary glands. The afferents of the submaxillary glands drain the medial palpebral commissure, the cheek, the side of the nose, the upper lip, the lateral part of the lower lip, the gums, and the anterior part of the margin of the tongue. Efferent vessels from the facial and submental glands also enter the submaxillary glands. Their efferent vessels pass to the superior deep cervical glands. [WP,unvetted].
A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles.
TODO - align this with the CARO2 class 'appendage segment'; note the FMA class does not appear to require repetition
FMA has both limb segment and free limb segment, the former includes the girdles. Note that MA uses the term more generally and includes A,S,Z,S+Z(arm/leg), whereas FMA is just A,S,Z
An organ that functions as a secretory or excretory organ.
Fin that is one of a pair located ventrally on the organism.
Anatomical surface structure found in many aquatic organisms. It is a respiration organ whose function is the extraction of oxygen from water and the excretion of carbon dioxide. The microscopic structure of a gill is such that it presents a very large surface area to the external environment. Gills usually consist of thin filaments of tissue, branches, or slender tufted processes which have a highly folded surface to increase surface area. A high surface area is crucial to the gas exchange of aquatic organisms as water contains only 1/20 parts dissolved Oxygen compared to air. With the exception of some aquatic insects, the filaments and lamellae (folds) contain blood or coelomic fluid, from which gases are exchanged through the thin walls. Oxygen is carried by the blood to other parts of the body. Carbon dioxide passes from the blood through the thin gill tissue into the water. Gills or gill-like organs, located in different parts of the body, are found in various groups of aquatic animals, including mollusks, crustaceans, insects, fish, and amphibians.
this term potentially applicable across multiple metazoa - see also the subclass 'pharyngeal arch derived gill'
A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans).
this class represents the entire organism subdivision encompassing soft tissue as well as the underlying skeletal framework. The class represents the phalangeal part only - historically the term 'digit' has also been used to represent the unit consisting of a series of phalanges together with a metapodial bone. We may in future relabel this class to avoid confusion with this concept, but the class will continue to represent the phalangeal portion
Our reinterpretation of the distal fin endoskeleton of Panderichthys removes the final piece of evidence supporting the formerly popular hypothesis that tetrapod digits are wholly new structures without homologues in sarcopterygian fish fins. This hypothesis, which was based partly on the complete absence of plausible digit homologues in Panderichthys (then the closest known relative of tetrapods), has already been called into question by the discovery of digit-like radials in Tiktaalik and the fact that Hox gene expression patterns closely resembling those associated with digit formation in tetrapods occur in the distal fin skeletons of paddlefish and Australian lungfish. Our new data show that Panderichthys is not an anomaly: like Tiktaalik and other fish members of the Tetrapodomorpha, it has distal radials that can be interpreted as digit homologues.[well established][VHOG]
digit (phalangeal portion) plus soft tissue
A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle.
TODO discriminate between stages and organisms
Whole organism that is premetamorphic or a very immature individual.[TAO]
Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.
Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.
anteromedial part of ventral lateral posterior nucleus (jones)
nucleus lateralis intermedius mediodorsalis situs ventralis medialis
nucleus ventralis oralis, pars posterior (dewulf)
nucleus ventrooralis internus, superior part
nucleus ventro-oralis internus (Hassler)
The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted].
segmenta thoracica medullae spinalis [1-12]
Gonochoristic organism that can produce male gametes.
Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.
Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA]
Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.
this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs
The outermost extraembryonic membrane of amniotes.
The outer membrane enclosing the embryo in reptiles, birds, and mammals. [TFD][VHOG]
The outer membrane of the two membranes enclosing the embryo in reptiles, birds, and mammals. In placental mammals it contributes to the development of the placenta[BTO:0000252].
The chorion of placentals is bilaminar as in reptiles and birds, but forms from the trophoblast and includes the ajdacent mesodermal layer [ISBN:0073040584]
This term refers to the amniote structure. It is distinct from the concept of chorion in insects
The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph].
An elongated tube which carries air to and from the lungs.[AAO]
The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]
In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG]
In birds, the trachea runs from the pharynx to the syrinx, from which the primary bronchi diverge. Swans have an unusually elongated trachea, part of which is coiled beneath the sternum; this may act as a resonator to amplify sound. In some birds, the cartilagenous rings are complete, and may even be ossified. In amphibians, the trachea is normally extremely short, and leads directly into the lungs, without clear primary bronchi. A longer trachea is, however found in some long-necked salamanders, and in caecilians. While there are irregular cartilagenous nodules on the amphibian trachea, these do not form the rings found in amniotes. The only vertebrate to have lungs, but no trachea, is Polypterus, in which the lungs arise directly from the pharynx.
GO uses genitalia for the singular organ
The epithelial layer of the luminal surfaces of the mammary gland.
The portion of the yolk sac that is derived from endoderm and lines the yolk sac.
A layer of epithelial cells on the surface of the mucosa.
A gland that is part of a digestive tract [Automatically generated definition].
A bone that is part of a head [Automatically generated definition].
Different sources vary regarding which bones are craniofacial; e.g. hyoid bone
A bone that is part of a trunk [Automatically generated definition].
A bone that is part of a hindlimb region. Examples: any pes phalanx, femur. Counter-examples: ischium, pubis (they are part of the pelvic girdle).
the MA class is actually bone of pelvic complex; in contrast the NCIT class excludes ilium etc
A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.
only in MA - supertype of artery, arteriole, aorta.
A bone that is part of a mesopodial skeleton.
The carpus (wrist) and tarsus (ankle) of land vertebrates primitively had three rows of carpal or tarsal bones. Often some of these have become lost or fused in evolution. Three proximals. In the hand humans has all three. In the foot the middle proximal appears in 5-15% of people as an os trigonum. Centrale or os centrale, on the medial side. In humans and our closest relatives the African apes (chimpanzees and gorillas) it fuses to the scaphoid where it forms the articulation with the trapezoid bone; occasionally it stays separate. In Man's foot it is the navicular. Some early land vertebrates had more than one (up to three) os centrale per hand or foot. Distals, one per finger / toe at the base of each metacarpal or metatarsal. In mammals the 4th and 5th fuse. In the horse the 1st is lost
A small fluid-filled sac lined by synovial membrane with an inner capillary layer of slimy fluid. It provides a cushion between bones and tendons and/or muscles around a joint. This helps to reduce friction between the bones and allows free movement. Bursae are filled with synovial fluid and are found around most major joints of the body.
The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity).
in FMA this contains the pelvic cavity, but this is inconsistent with the concept of abdominopelvic cavity
A fold of peritoneum originating at the stomach and supporting the viscera.
A collection of sacral vertebrae in the sacral region that are fused and part of the bony pelvis.
the AAO class 'sacrum' is deliberately placed under 'sacral vertebra' rather than here
The Achilles tendon is a tendon of the posterior leg. It serves to attach the plantaris, gastrocnemius (calf) and soleus muscles to the calcaneus (heel) bone.
in FMA this is a ligament, and part of the muscle
The sensory organs in muscle that are involved in the stretch reflex.
The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants.
FMA:24979 denotes the middle segment (zeugopod), its placement here is correct. See obo-anatomy archives for discussion
Naming conventions for pod terms under discussion within phenoscape group. TODO - add distinct term for skeleton and place AAO class here
A bone that is part of an abdominal segment of trunk [Automatically generated definition].
bone organ of abdominal segment of trunk
Initial section of the oviduct through which the ova pass from the ovary to the uterus.
Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma.
The part of the retina that contains neurons and photoreceptor cells[GO].
(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]
Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers
Any endothelium that has the quality of being cylindrical [Automatically generated definition].
A duct that is part of a digestive system [Automatically generated definition].
An epithelium that lines the lumen of the digestive tract.
Epithelium lining the lumen of the gut.[TAO]
Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.
The lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes.
Any tube, opening or passage that connects two distinct anatomical spaces.
FMA has both conduit and conduit space. In EHDAA2 this is a surface feature
An anatomical structure that develops (entirely or partially) from the endoderm.
An anatomical structure that develops (entirely or partially) from the mesoderm.
An anatomical structure that develops (entirely or partially) from the ectoderm.
In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the loop of Henle. It has a brush border epithelial morphology[GO].
TODO - ensure definition works across species.
The external genitalia are the outer sex organs, such as the penis or vulva in mammals.
TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547
Organ that is part of the hematopoietic system.
consider splitting out lymph organ, compare with lymph node
the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs].
the FMA class 'lymphoid organ' is a general anatomical term
The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron.
A muscular coat that is part of a vas deferens [Automatically generated definition].
TODO - check MA and FMA classes mean the same thing
A bone that is part of the dorsal region of an animal.
this class may be obsoleted. See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/93
Upper part of skull, consisting of parietals, frontals, post-parietals, and in some species the squamosal and a portion of the alisphenoid.
We follow http://www.ncbi.nlm.nih.gov/pubmed/11523816 (Morriss-Kay) in definingenumerating the components of the skull vault. Note that there is a conflict with Kardong; e.g. in fig 7.10, Kardong places the squamosal in the temporal series. We cannot place the vault as entirely part of the dermatocranium as it has a small splanchnocranium contribution and a sclerotomal contribution
The earliest tetrapods arose from rhipidistian ancestors and retained many of their skull features, including most of the bones of the dermatocranium.[well established][VHOG]
Terminology notes. we include calvarium as a synonym, but Gray's Anatomy's list includes the Ethmoid and Sphenoid bone in the Calvaria. Some books (and HPO) state that calvaria consists of just the frontal bone, parietal bone, temporal bone, and occipital bone. Note vault may not be precisely equivalent to calvaria
An eye that is part of a left side of organism [Automatically generated definition].
An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.
An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart.
An endothelium that is part of an arterial system [Automatically generated definition].
An appendage that is part of an appendage girdle complex.
this class is the union of the classes limb, pectoral fin and pelvic fin.
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
A serous membrane that is part of a digestive system [Automatically generated definition].
serous membrane of gastrointestinal system
The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall.
endothelium of trunk of systemic arterial tree
trunk of systemic arterial tree endothelium
An endothelium that is part of the cardiovascular system.
A mesentery that is part of a digestive system [Automatically generated definition].
Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts.
A proximal-distal subdivision of the digestive tract.
intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct.
A part of a wall of an organ that forms a layer.
A mucosa that is part of a vagina [Automatically generated definition].
A cluster of neurons that is the most prominent longitudinally extending condensed part of a nervous system.
some species have multiple longitudinal nerve cords; this class refers to the most prominent one, which is dorsal in chordates and ventral in others.
An organ that is part of a immune system [Automatically generated definition].
Any anatomical structure that is part of the reproductive system.
The anterior or ventral portion of the medulla oblongata is named the pyramid and lies between the anterior median fissure and the antero-lateral sulcus. Its upper end is slightly constricted, and between it and the pons the fibers of the abducent nerve emerge; a little below the pons it becomes enlarged and prominent, and finally tapers into the anterior funiculus of the medulla spinalis, with which, at first sight, it appears to be directly continuous[WP].
A structure consisting mainly of cell components, rather than complete cells.
we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.'
Such a structure may contain some complete cells in addition to partial cells (e.g., glia in nervous system regions).
An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.
An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.
An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.
An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.
An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.
An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis.
An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.
Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo.
An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO].
One of: the common carotid artery, or its branches, the external and internal carotid arteries.
This is a generic grouping class that is the superclass of the trunks/branches of the common carotid artery. Note that AOs vary widely in how they divide up and generalize arteries
Artery originating at the junction of the first two aortic arches and supplying the anterior brain. Kimmel et al, 1995.[TAO]
Any of the arteries that arise from a bifurcation of the aorta supplying the pelvic or abdomen. Examples: Common iliac artery, External iliac artery, Internal iliac artery.
this is an extremely loose and flexible grouping class that is the superclass of the mammalian common iliac and its main brahces, together with analagous structures in other tetrapods
we place the XAO structure here for now. In terms of analagy, it is more closely related to common iliac, but the relationships currently attached to this class are mammal specific
Any of the three veins including the common, external and internal iliac veins.
The amnion and chorion which surround and protect a developing fetus.
TODO - merge with extraembryonic membrane?
Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo.
stuctures homologous to the four extraembryonic membranes appear in mammals [ISBN:0073040584 (Vertebrates, Kardong)]
Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle.
A bone that is part of the pes skeleton.
Any of the ducts that are part of a male reproductive system.
this class groups the individual ducts in a variety of species
Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA].
Any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain.
any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain[MP]
A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions).
Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
A tube that is part of a excretory system.
Denser fibrous covering over one of: penis, testicles or ovaries.
The dense fibrous connective tissue layer that covers the testis.
The layer of connective tissue covering the testicles. [Wikipedia_(15/09/09)][VHOG]
The tunica albuginea testis is the major component of the capsule of mammalian testes. (...) Our results from studying the mole provide evidence that the spatio-temporal pattern of testis development is not perfectly conserved in mammals, since we found differences with respect to the mouse testis organogenesis. This fact is even more significant when we consider that, apart from the mouse, the mole is probably the one of the best-known mammalian species in terms of the genetic control of testis development, implying that more peculiarities would be found if more species were investigated.[uncertain][VHOG]
A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis.
currently this class conflates a generic layer of muscle and a specific layer found lining the digestive tract (the muscularis externa), typically composed of circular and longitudinal layers (although this varies)
An outer layer of smooth muscle surrounding a hollow or tubular organ as the bladder, esophagus, large intestine, small intestine, stomach, ureter, uterus, and vagina that often consists of an inner layer of circular fibers serving to narrow the lumen of the organ and an outer layer of longitudinal fibers serving to shorten its length[BTO].
typically smooth muscle, but there may be exceptions - in the upper esophagus, part of the externa is skeletal muscle, rather than smooth muscle.
A smooth muscle tissue that bridges the gap between free ends of C-shaped cartilages at the posterior border of the trachea, adjacent to the esophagus. A primary function of the trachealis is to constrict the windpipe, allowing for higher velocity of air in the windpipe during coughing[WP, modified].
This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO].
keep this grouping class so long as it is required for GO
An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.
FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium
Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA].
Any gland that is part of the digestive system.
The pit in the center of the abdominal wall marking the point where the umbilical cord entered in the fetus.
The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].
this grouping class exists primarily to align with GO - see GO:0008544.
An epithelial tube that is open at one end only.
An anatomical structure that connects two structures.
the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts
Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.
characteristically low in protein and cellular content (unless there has been secondary concentration)
The serous fluid which accumulates in the peritoneal cavity in ascites.
TODO - move to pathological anatomical entity ontology
Mesentery that is located in the peritoneum.
A bone element or fused bone that is part of pelvic girdle.
check sacrum, coccyx (MA does NOT include these)
typically the ilium, ischium and pubis. These can alternately be considered individual bones, or zones of a single fused bone
Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).
Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).[VSAO]
Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.[FMA]
dense regular collagenous connective tissue
typus regularis (textus connectivus collagenosus compactus)
The external junctural region between the lower part of the abdomen and the thigh.
A limb segment that is part of a hindlimb.
Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO].
Intramembranous bone that forms superficially in the organism.[TAO]
other AOs are not yet in sync with this classification
The axilla is the area directly under the joint where the forelimb connects to the shoulder.
A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
this class groups vertebrate nephron tubules with analagous structures such as insect Malpighian tubules
Branch or outpocketing of the digestive tract.
An anatomical structure that has more than one cell as a part.
Gland of the epithelium lining the oral cavity. The most common are the salivary glands.
Note that Kardong classifies lacrimal glands here. EHDAA2 includes pituitary primordium, as this develops from oral mucosa
One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta.
An anatomical structure that develops from the neural crest.
An anatomical structure that has some part that develops from the neural crest.
structure with developmental contribution from neural crest
A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification.
There are three cuneiform bones in the human foot: the medial cuneiform the intermediate cuneiform also known as the middle the lateral cuneiform. They are located between the navicular bone and the first, second and third metatarsal bones and are medial to the cuboid bone[WP, unvetted, human specific].
Series of elements that articulate with the metatarsals.[AAO]
A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle).
A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle.
the MA class called 'hindlimb bone' belongs here, as it includes bones in the pelvic girdle
A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg.
subdivision of organism along appendicular axis
A bone that is part of a neurocranium [Automatically generated definition].
A multi cell part structure that is part of a central nervous system.
central nervous system cell part cluster
A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones.
A retractable double-layered fold of skin and mucous membrane that covers the glans penis or clitoris. Glands may also be present.
this is a generic sex-neutral grouping class for the male and female prepuce. Note that this structure is a combination of skin and other tissue
A commissure that is part of a diencephalon.
A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.
Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem
subdivision of organism along main body axis
Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.
Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT]
typus irregularis (textus connectivus collagenosus compactus)
Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.
our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid.
Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT]
Epithelium that derives from the mesoderm. [Automatically generated definition].
A bone element that is part of a jaw region.
Do not manually classify under here - bones are automatically classified
A section through the tube or network of tubes that connects the ovaries to the outside of the body.
FMA class may only represent the uterine portion
A zone of soft tissue located on the posterior of the lateral side of the pelvic region corresponding to the gluteal muscles.
Anatomical projection that is part of the integumentl system.
An organ component layer that is part of a integumental system.
Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.
Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart.
Groupings may vary - typically pulmonary vessels and aorta and vena cavae
Is part of the pelvis on the edge of the wing of the ilium. Round in shape, dorsal to the pubis and ischium. Acts as structrure that muscles can attach too.
A blood vessel that drains from from an eyelid.
A hindlimb bone or its cartilage or pre-cartilage precursor.
A tarsus bone or its cartilage or pre-cartilage precursor.
An ischial bone or its cartilage or pre-cartilage precursor.
A limb bone or its cartilage or pre-cartilage precursor.
An endochondral element that is part of a autopod region.
A distal mesopodial endochondral element that is part of a hindlimb.
Any structure that is placed on one side of the left-right axis of a bilaterian.
This class is primarily to implement taxon constraints. It may be removed in the future.
An endochondral element in the distal portion of the mesopodial skeleton, between the central mesopodial skeleton and the metapodial skeleton.
A distal mesopodial endochondral element that is composed primarily of a bone tissue.
Any organ component layer that consists of muscle tissue.
NCITA class may refer to smooth muscle only
A membranous sac in animals that serves as the receptacle of a liquid or contains gas.
An exocrine gland that is part of a integumental system.
Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].
this is currently used to group some cellular layers that may not strictly conform to the CARO definition of cell-part layer. Consider genericisizing and introducing subtypes for cellular layer, fibrous layer and cell soma layer
An multicellular anatomical structure that has subparts of multiple organs as a part.
A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.
organ region with floating fiat boundary
A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity.
A bodily fluid that is located in the coelom.
he coelomic fluid serves several functions; it acts as a hydroskeleton, it allows free movement and growth of internal organs, it serves for transport of gases, nutrients and waste products between different parts of the body, it allows storage of sperm and eggs during maturation and it acts as a reservoir for waste [Wikipedia:Coelom#Coelomic_fluid]
A striated muscle tissue that is associated with soft internal organs (viscera).
An organization that stores a large number of cell lines. Its website is: http://www.atcc.org.
ATCC
an organization that serves as a cell ine repository. Its website is: http://bioinformatics.istge.it/hypercldb/.
an organization that stores a large number of cell lines. Its website is: http://ccr.coriell.org/.
Coriell Cell Line Repositories
an organization that serves as a cell ine repository. Its website is: http://www.brc.riken.jp/lab/cell/english/.
RIKEN Cell Bank
The LINCS Proteomic Characterization Center for Signaling and Epigenetics at the Broad Institute
PCCSE
BROAD_T
This donor was used to generate several stem cell lines, including EDi008-A and EDi008-B.
hPSCreg is a freely accessible global registry for human pluripotent stem cell lines (hPSC-lines), which is managed by Charité / BCRT. The registry allows searching for cell lines and for information available about these cell lines. New cell lines can be registered and information can be added to already registered cell lines.
hPSCreg
example to be eventually removed
failed exploratory term
The term was initially used in an attempt to structure part of the ontology, but in retrospect failed to do a good job.
Terms created as placeholders with the expectation of being permanent should instead be deprecated using the "placeholder removed" (obo:IAO_0000226) justification.
metadata complete
Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.
organizational term
The term was created to ease viewing/sorting terms for development purposes, but will not be included in a release.
ready for release
Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release."
metadata incomplete
Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.
uncurated
Nothing done yet beyond assigning a unique class ID and proposing a preferred term.
pending final vetting
All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor.
Core is an instance of a grouping of terms from an ontology or ontologies. It is used by the ontology to identify main classes.
obsolete_core
placeholder removed
The term was created to temporarily stand in for a semantic purpose, but is no longer needed, typically due to another permanent term being defined.
This reason is appropriate for a temporary term even if no permanent term is defined; for example if the need for the term no longer exists. If a permanent (replacement) term is defined, the deprecated term should reference the replacement with IAO:0100001. If no replacement is defined, it may be appropriate to reference alternative terms with oboInOwl:consider.
terms merged
The term has been combined with one or more other terms to create a more encompassing (merged) term.
The deprecated term should reference the merged term with obo:IAO_0100001. The replacement term should reference the original terms as sources using obo:RO_0001000 (derives_from). An editor note should explain what were the merged terms and the reason for the merge.
term imported
The term has been replaced by a term imported from another ontology.
This is to be used when the original term has been replaced by a term imported from an other ontology. The deprecated term should reference the imported term with obo:IAO_0100001.
term split
The term has been split into two or more new terms.
This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split. The deprecated term should reference the replacement terms with obo:IAO_0100001.
universal
Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents.
A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf
defined class
A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal
"definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal.
named class expression
A named class expression is a logical expression that is given a name. The name can be used in place of the expression.
named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions
to be replaced with external ontology term
Terms with this status should eventually replaced with a term from another ontology.
requires discussion
A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.
The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not.
This obsolesence reason should be used conservatively. Typical valid examples in disease ontologies are: unnecessary class grouping; mistaked creation of a disease associated to a phenotype.
The term was added to the ontology on the assumption it was a valid domain entity, but it turns out the entity does not exist in reality.
This obsolesence reason should be used conservatively. For example: Obsoleting class that describes a breed of cow based on a record in an existing database, that was later retracted as faulty (breed does not exist). Do not use this term to obsolete a historic concept (that was once valid, but not anymore).
## Elucidation This is used when the statement/axiom is assumed to hold true 'eternally' ## How to interpret (informal) First the "atemporal" FOL is derived from the OWL using the standard interpretation. This axiom is temporalized by embedding the axiom within a for-all-times quantified sentence. The t argument is added to all instantiation predicates and predicates that use this relation. ## Example Class: nucleus SubClassOf: part_of some cell forall t : forall n : instance_of(n,Nucleus,t) implies exists c : instance_of(c,Cell,t) part_of(n,c,t) ## Notes This interpretation is *not* the same as an at-all-times relation
axiom holds for all times
an immortal cell line cell derived from human cervix.