]> Jiangan Xie Stephan Schurer 2.1.135 Alex Ade Alexander Diehl Allen Xiang Asiyah Yu Lin Caty Chung Matthew Brush Uma Vempati 2018-01-26 An ontology for the domain of cell lines and cell line cells CLO: Cell Line Ontology Daniel Cooper Draft version Helen Parkinson Hiroshi Masuya James Malone Jie Zheng OWL-DL Sirarat Sarntivijai The Cell Line Ontology. Yongqun "Oliver" He (YH) Yue Liu BFO OWL specification label BFO OWL specification label BFO OWL specification label Really of interest to developers only Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. BFO CLIF specification label BFO CLIF specification label Person:Alan Ruttenberg BFO CLIF specification label Really of interest to developers only Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 LINCS ID An annotation property that represents an ID used in the NIH LINCS project. Oliver He, Jiangan Xie, Jie Zheng STR profile An annotation property that specifies an STR profile of a cell line cell. Yongqun He PubChem AID An annotation property that represents a PubMed BioAssay Identifier accession number. Oliver He https://pubchem.ncbi.nlm.nih.gov/help.html problematic cell line annotation An annotation property that describes the information of a problematic cell line. Yongqun He cell line cell origin Oliver He An annotation property that describes the origin of a cell line. cell line cell feature An annotation property that describes the features of a cell line and cell line cell. Oliver He Known mutation annotation An annotation property that describes known mutation(s) about a cell. Oliver He Cell culture condition editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label editor preferred label GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) editor preferred label editor preferred term example of usage example of usage A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober example example of usage in branch in branch An annotation property indicating which module the terms belong to. This is currently experimental and not implemented yet. GROUP:OBI OBI_0000277 in branch has curation status has curation status OBI_0000281 PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot has curation status definition textual definition textual definition definition definition 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. definition editor note editor note editor note IAO:0000116 editor_note editor_note true uberon An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. GROUP:OBI:<http://purl.obfoundry.org/obo/obi> PERSON:Daniel Schober editor note term editor term editor 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. GROUP:OBI:<http://purl.obolibrary.org/obo/obi> Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people PERSON:Daniel Schober term editor alternative term alternative term An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober alternative term definition source definition source Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Daniel Schober definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 curator notes curator note curator note curator notes IAO:0000232 curator_notes curator_notes true uberon An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg curator note imported from imported from For external terms/classes, the ontology from which the term was imported GROUP:OBI:<http://purl.obolibrary.org/obo/obi> PERSON:Alan Ruttenberg PERSON:Melanie Courtot imported from expand expression to expand expression to elucidation elucidation Person:Barry Smith Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms elucidation person:Alan Ruttenberg has associated axiom(nl) has associated axiom(nl) An axiom associated with a term expressed using natural language Person:Alan Ruttenberg Person:Alan Ruttenberg has associated axiom(nl) has associated axiom(fol) has associated axiom(fol) An axiom expressed in first order logic using CLIF syntax Person:Alan Ruttenberg Person:Alan Ruttenberg has associated axiom(fol) term replaced by temporal interpretation temporal interpretation https://code.google.com/p/obo-relations/wiki/ROAndTime https://github.com/oborel/obo-relations/wiki/ROAndTime An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. temporal interpretation dubious_for_taxon dubious_for_taxon RO:0002174 S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. dubious_for_taxon dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost true true uberon present_in_taxon present_in_taxon RO:0002175 S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S applicable for taxon present_in_taxon present_in_taxon true true uberon external_definition external_definition An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000001 external_definition external_definition true uberon axiom_lost_from_external_ontology axiom_lost_from_external_ontology A textual description of an axiom loss in this ontology compared to an external ontology. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000002 axiom_lost_from_external_ontology axiom_lost_from_external_ontology true uberon homology_notes homology_notes Notes on the homology status of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000003 homology_notes homology_notes true uberon external_comment external_comment An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000005 external_comment external_comment true uberon implements_design_pattern implements_design_pattern UBPROP:0000006 implements_design_pattern implements_design_pattern true uberon has_relational_adjective has_relational_adjective UBPROP:0000007 Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. has_relational_adjective has_relational_adjective true uberon taxon_notes taxon_notes Notes on the how instances of this class vary across species. UBPROP:0000008 taxon_notes taxon_notes true uberon function_notes function_notes Notes on the evolved function of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000009 function_notes function_notes true uberon structure_notes structure_notes Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 structure_notes structure_notes true uberon development_notes development_notes Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 development_notes development_notes true uberon external_ontology_notes external_ontology_notes Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 external_ontology_notes external_ontology_notes true uberon terminology_notes terminology_notes Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000013 terminology_notes terminology_notes true uberon fma_set_term fma_set_term FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term UBPROP:0000202 fma_set_term fma_set_term true uberon contributor Contributor Contributor dc-contributor dc-contributor true uberon An entity responsible for making contributions to the content of the resource. Examples of a Contributor include a person, an organisation, or a service. Typically, the name of a Contributor should be used to indicate the entity. Creator Creator An entity primarily responsible for making the content of the resource. Examples of a Creator include a person, an organisation, or a service. Typically, the name of a Creator should be used to indicate the entity. Date Date A date associated with an event in the life cycle of the resource. Typically, Date will be associated with the creation or availability of the resource. Recommended best practice for encoding the date value is defined in a profile of ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format. Description Description An account of the content of the resource. Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content. Format Format The physical or digital manifestation of the resource. Typically, Format may include the media-type or dimensions of the resource. Format may be used to determine the software, hardware or other equipment needed to display or operate the resource. Examples of dimensions include size and duration. Recommended best practice is to select a value from a controlled vocabulary (for example, the list of Internet Media Types [MIME] defining computer media formats). Source Source A reference to a resource from which the present resource is derived. The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system. Subject and Keywords Subject and Keywords The topic of the content of the resource. Typically, a Subject will be expressed as keywords, key phrases or classification codes that describe a topic of the resource. Recommended best practice is to select a value from a controlled vocabulary or formal classification scheme. Title Title Typically, a Title will be a name by which the resource is formally known. A name given to the resource. consider has_alternative_id has_alternative_id has_broad_synonym has_broad_synonym database_cross_reference database_cross_reference has_exact_synonym has_exact_synonym has_narrow_synonym has_narrow_synonym has_obo_namespace has_obo_namespace has_related_synonym has_related_synonym in_subset in_subset shorthand shorthand label depicted_by part_of part of Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. http://www.obofoundry.org/ro/#OBO_REL:part_of Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. a core relation that holds between a part and its whole is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) part_of this day is part of this year (occurrent parthood) has part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'. a core relation that holds between a whole and its part has part has_part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) realized in Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) is realized by realized in realized_in this disease is realized in this disease course this fragility is realized in this shattering this investigator role is realized in this investigation realizes Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realizes this disease course realizes this disease this investigation realizes this investigator role this shattering realizes this fragility to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) participates_in located_in has_quality http://www.ebi.ac.uk/efo/has_quality derives from patient having disease In most cases, the patient in the relation is used to refer human patient. However, an animal patient (or veterinary patient) can also be referred. a 'derives from' object property between an entity (in CLO case, cell line) and a disease in a patient where the entity is derived from some cell in the patient who has the disease. This is a short cut relation that represents: 'derived from' some (cell and ('part of' some 'organism' and ('has disease' some disease))) Yongqun He has disease Jie Zheng, Yongqun He, Yu Lin, Allen Xiang This is a shortcut relation. It is equivalent to: participates_in some 'disease couse' and realizes some disease a disease disposition has been realized by a bearer. is in cell line repository an object property that specifies a cell line repository for a specifc cell line. SS, YH, UV, SS is disease model for an object property that represents a relation between a cell line cell and a disease. Asiyah Yu Lin, Yongqun He This object property is largely equivalent to the previous term 'is model for' (http://www.ebi.ac.uk/cellline#is_model_for). transfected to express an object property that represents a relation between a cell line cell and a protein where the cell line cell is genetically transfected to stably express a foreign protein in the cell line cell. Oliver He, Asiyah Yu Lin HeLa ICRP cell is transfected to express a Initiator caspase reporter protein (IC-RP) derived from organism a 'cell line cell derives from' object property between an entity (e.g., cell line cell in CLO) and an organism where the cell line cell is derived from some cell from the organism. In CLO, this is a short cut relation that represents: 'derived from' some (cell and ('part of' some organism)) derived from anatomic part a 'derives from' object property between an entity (i.e., cell line cell in CLO) and an anatomic part from an organism where the cell line cell is derived from some cell in the anatomic part (e.g., tissue or organ). The anatomic part is typically defined by UBERON in CLO. in CLO, this is a short cut relation that represents: 'derived from' some (cell and ('part of' some 'anatomic part')) derived from cell derived from cell line cell line cell derived from a 'derived from' object property that specifies the domain of the property is a cell line cell. Oliver He cell line cell derived from anatomical part a 'cell line cell derives from' object property between a cell line cell and an anatomic part from an organism where the cell line cell is derived from some cell in the tissue. The anatomic part is typically defined by UBERON in CLO. This is a short cut relation that represents: 'derived from' some (cell and ('part of' some 'anatomic part')) Oliver He cell line cell derived from organism Oliver He a 'cell line cell derives from' object property between a cell line cell and an organism where the cell line cell is derived from some cell from the organism. This is a short cut relation that represents: 'derived from' some (cell and ('part of' some organism)) induced by cell culture reagent is about 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. We will try to build it back up by elaborating the various subproperties that are more precisely defined. Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. Smith, Ceusters, Ruttenberg, 2000 years of philosophy This document is about information artifacts and their representations is about is_about is a (currently) primitive relation that relates an information artifact to an entity. person:Alan Ruttenberg mentions 7/6/2009 Alan Ruttenberg. P4 RC1 munges our GCI so remove it for now: mentions some entity equivalentTo has_part some ('generically denotes' some entity) 7/6/2009 Alan Ruttenberg: Add this relation following conversation with Jonathan Rees that N&S GCI for is_about was too strong. Really it was simply sufficient. To effect this change we introduce this relation, which is subproperty of is_about, and have previous GCI use this relation "mentions" in it's (logical) definition An information artifact IA mentions an entity E exactly when it has a component/part that denotes E PERSON: Jonathan Rees Person: Alan Ruttenberg has_specified_input 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works. PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Coutot A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. PERSON: Alan Ruttenberg has_specified_input see is_input_of example_of_usage is_specified_input_of PERSON:Bjoern Peters A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. Alan Ruttenberg is_specified_input_of some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay has_specified_output PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Courtot A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. PERSON: Alan Ruttenberg has_specified_output is_manufactured_by Alan Ruttenberg Liju Fan c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this. has_make has_manufacturer http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities) is_manufactured_by is_specified_output_of PERSON:Bjoern Peters A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. Alan Ruttenberg is_specified_output_of achieves_planned_objective A cell sorting process achieves the objective specification 'material separation objective' BP, AR, PPPB branch PPPB branch derived This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. achieves_planned_objective modified according to email thread from 1/23/09 in accordince with DT and PPPB branch has grain PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349 has grain the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car. Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form PERSON: Alan Ruttenberg objective_achieved_by This relation obtains between a a objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process. objective_achieved_by OBI OBI inheres in A dependent inheres in its bearer at all times for which the dependent exists. a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence inheres in inheres_in this fragility inheres in this vase this red color inheres in this apple bearer of A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence bearer of bearer_of is bearer of this apple is bearer of this red color this vase is bearer of this fragility participates in a relation between a continuant and a process, in which the continuant is somehow involved in the process participates in participates_in this blood clot participates in this blood coagulation this input material (or this output material) participates in this process this investigator participates in this investigation has participant Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. a relation between a process and a continuant, in which the continuant is somehow involved in the process has participant http://www.obofoundry.org/ro/#OBO_REL:has_participant has_participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) concretizes A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant). A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process). concretizes has function A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence has function has_function this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) derives_from derives from This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'. a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity derives from derives_from this cell derives from this parent cell (cell division) this nucleus derives from this parent nucleus (nuclear division) derives into This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'. a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity derives into derives_into this parent cell derives into this cell (cell division) this parent nucleus derives into this nucleus (nuclear division) located in a relation between two independent continuants, the target and the location, in which the target is entirely within the location ends after David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) happens during X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) d during David Osumi-Sutherland ends during David Osumi-Sutherland o overlaps X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). has plasma membrane part Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part. overlaps http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) x overlaps y if and only if there exists some z such that x has part z and z part of y develops from x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y develops into capable of A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. capable of part of c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. developmentally preceded by Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p developmentally succeeded by Inverse of developmentally preceded by mereotopologically related to A mereological relationship or a topological relationship Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships developmentally related to A relationship that holds between entities participating in some developmental process (GO:0032502) functionally related to has developmental potential involving x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). has potential to develop into x has the potential to develop into y iff x develops into y or if x is capable of developing into y has potential to directly develop into x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y causally related to This relation groups causal relations between material entities and causal relations between processes existence starts during RO:0002488 Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. begins_to_exist_during existence_starts_during existence_starts_during uberon existence starts with RO:0002489 Relation between continuant and occurrent, such that c comes into existence at the start of p. existence_starts_with existence_starts_with uberon existence starts during or after RO:0002496 existence_starts_during_or_after existence_starts_during_or_after uberon causal agent in A relationship between a material entity and a process where the material entity has some causal role that influences the process causal relation between material entity and a process A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. has causal agent Inverse of 'causal agent in' related via dependence to A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. produces a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix. produced by a produced_by b iff some process that occurs_in b has_output a. has_completed has_high_plasma_membrane_amount A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). has_low_plasma_membrane_amount A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). has_not_completed lacks_part http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y lacks_plasma_membrane_part http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y) is model for a relation that indicates a cell line cell is a model for studying a disease. Domain: a cell line cell Range: a disease. has_disease_location contained_in peripheral vein SNOMEDID: T-48097 URI: http://www.ebi.ac.uk/cellline#Structure_of_peripheral_vein amniotic fluid Aqua Amnii Liquor Amnii The fluid within the amniotic cavity which surrounds and protects the developing embryo. (NCI)CDISC Amniotic cavity fluid which is produced by the AMNION and fetal lungs and kidneys.MSH2001 The fluid within the amniotic cavity which surrounds and protects the developing embryo. It is initially produced by the amnion and then later by the lungs and kidneys. The amount at term normally varies from 500 to 2000 ml. UMLS: C0002638 URI: http://www.ebi.ac.uk/cellline#Amniotic_fluid Waters (Amniotic Fluid) amniotic sac UMLS: C0883994 URI: http://www.ebi.ac.uk/cellline#Amniotic_Sac chorionic villus Tiny vascular tissue projections from the membranous sac that surrounds the embryo. UMLS: C0008508 URI: http://www.ebi.ac.uk/cellline#Chorionic_Villus embryonic fluid Embryonic Fluids Embryonic Tissue, Fluids, Secretions UMLS: C1516820 URI: http://www.ebi.ac.uk/cellline#Embryonic_Fluid gonad A reproductive system organ that produces and releases either sperm (testis) or eggs (ovary). Gonadal Gonads The part of the reproductive system that produces and releases eggs (ovaries) or sperm (testicles/testes).NCI-GLOSS UMLS: C0018067 URI: http://www.ebi.ac.uk/cellline#Organ iliac vein A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.MSH2001 UMLS: C0020888 URI: http://www.ebi.ac.uk/cellline#Iliac_Vein rhomboid Rhomboid (body structure) Rhomboid - muscle UMLS: C1260952 UMLS: T-13606 URI: http://www.ebi.ac.uk/cellline#Rhomboid entity entity BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf Julius Caesar Verdi’s Requiem entity the Second World War your body mass index continuant continuant Continuant (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants continuant if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) occurrent (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] An entity that has temporal parts and that happens, unfolds or develops through time. BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. occurrent Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) occurrent independent continuant IndependentContinuant (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) ic a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) independent continuant the bottom right portion of a human torso the interior of your mouth process Process (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) process process the course of a disease the flight of a bird the life of an organism your process of aging. disposition (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. Disposition (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] disposition If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) an atom of element X has the disposition to decay to an atom of element Y b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. disposition the cell wall is disposed to filter chemicals in endocytosis and exocytosis realizable entity (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) RealizableEntity To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) realizable realizable entity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet quality (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] quality Quality (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril specifically dependent continuant (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] SpecificallyDependentContinuant A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. sdc specifically dependent continuant the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. Role role (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) role the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role generically dependent continuant gdc (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] GenericallyDependentContinuant A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) generically dependent continuant the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. function (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] Function A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. function function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar material entity material (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) MaterialEntity An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) material entity the undetached arm of a human being anatomical structure material anatomical entity cell part chemical entity A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. CHEBI:24431 chebi_ontology chemical entity Collagen C4H6N2O3R2(C7H9N2O2R)n CAS:9064-67-9 CHEBI:3815 Collagen KEGG:C00211 chebi_ontology latrunculin A (+)-latrunculin A (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one 0 421.192 421.55000 A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. C22H31NO5S CAS:76343-93-6 CHEBI:43626 CHEBI:69136 DDVBPZROPPMBLW-IZGXTMSKSA-N InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1 LAT-A LATRUNCULIN A LatA NSC 613011 PDBeChem:LAR PMID:10859320 PMID:12087066 PMID:17897856 PMID:19528469 PMID:20677927 PMID:22492972 PMID:22498812 PMID:3200109 PMID:3556584 PMID:9250716 Reaxys:4239363 [H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\C=C/C=C/CC\C(C)=C/C(=O)O2)O1 chebi_ontology cell line cell culturing YH a maintaining cell culture process that keeps cell line cell alive and actively cultured. cell line cell cell line cell Yongqun He, Matthew Brush, Sirarat Sarntivijai, Alexander Diehl, Jie Zheng, Yu Lin, Bjoern Peters A 'cell line cell' is a part of a cell line established through the passaging/selection of a primary cultured cells or the experimental modification of an existing cell line. New types of cell line cells are established after sufficient passaging of a primary culture to establish a stable and homogenous population that qualifies as a line (typically 1-20 passages), or following some spontaneous or experimental modification that confers novel characteristics to an existing line. A cell line cell typically has mutations of five or more genes compared to the original cell that derives the cell line cell. Some gene mutations may turn on some oncogenes. Cell line cells can be in active culture, stored in a quiescent state for future use (e.g. frozen in liquid nitrogen), or applied in experimental procedures. A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture suspension cell line culturing suspension cell line culturing is a cell line culturing method where cells do not require a surface for growth and differentiation. This method is appropriate for cells that are adapted to suspension culture or cells that are non-adhesive (e.g. hematopoietic cells) adherent cell line culturing adherent cell line culturing is a cell line culturing method where cells require a surface for growth and differentiation. cell line cell modification a material processing that modifies an existing cell line cell to generate another cell line cell. Yongqun He cell line repository role a role that inheres in a cell line repository organization. SS, YH cell line repository SS, YH an organization that serves as a repository of cell lines. adherent on coated surface cell line culturing adherent on coated surface cell line culturing is an adherent cell line culturing method that the surface is coated with extracellular matrix component to increase adhesion properties and provide other signals needed for growth and differentiation. ATCC cell line cell ATCC cell line SS, YH, UV, SS a cell line cell that is in the ATCC cell line repository HyperCLDB cell line cell SS, YH, UV, SS a cell line cell that is in the HyperCLDB cell line repository HyperCLDB cell line immortal human T cell line cell YH an immortal human lymphocyte cell line cell that is derived from T cell. adherent on feeder cells cell line culturing adherent-patchy cell line culturing loosely adherent cell line culturing mouse, Swiss albino mortal cell line cell finite cell line cell Yongqun He, Matthew Brush, Sirarat Sarntivijai A cell line cell that is capable of replicating a limited number of times in culture before undergoing senescence. immortal cell line cell immortal cell line cell Yongqun He, Matthew Brush, Allen Xiang, Asiyah Yu Lin, Sirarat Sarntivijai, James Malone, Jie Zheng, Tomasz Adamusiak continuous cell line cell A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line. permanent cell line cell immortal human cell line cell a immortal cell line that is dervied from human tissue. YH immortal human cell line immortal cat cell line cell An immortal skin-derived cell line cell that derives from cat. Yongqun He immortal frog cell line cell An immortal skin-derived cell line cell that derives from frog. Yongqun He immortal hybrid cell line cell an immortal cell line cell that is generated by fusing two different types of cells. One of the parent cells is typically a cancer cell. Yongqun He immortal zebra fish cell line cell An immortal cell line cell that derives from zebra fish. Yongqun He mouse immortal cell line cell mouse immortal cell line suspension cell line cell suspension cell line a cell line that requires suspension cell cuturing. adherent cell line cell adherent cell line a cell line that is cultured through adherence cell culturing. adherent cell culture growth mode YH a cell culture growth mode that indicates a cell needs to adhere to a cell culture plate to grow. suspension cell culture growth mode YH a cell culture growth mode that indicates a cell can grow when the cell is suspended in cell culture medium. cell culture growth mode a disposition that represents a mode of cell culture growth, i.e., the cell will grow at a specific cell culture mode. For example, an adherent cell culture growh mode means that the cell will grow when the cell is adhere to a cell culture plate. YH cell line He, Tong-Chuan, et al., Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512.: "To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene". Note that common usage in the literature is often of the form "a human colorectal cancer cell line", as seen above. But such references to studies in "a line" refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'. A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture). MB, SS, JZ, MAH, BP, CS, YH A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture). In the spring of 2013, a working group comprised of domain experts and representatives from CLO, OBI, CL, and ReO worked to establish a consensus model and definitions of cultured cells across these efforts. This included a careful characterization of how the term 'cell line' should be defined and applied. Notes about this work and its outcomes can be found on the CLO wiki here: http://code.google.com/p/clo-ontology/wiki/Cell_Lines The term 'line' is used when a culture has undergone an intentional experimental process to establish a more uniform and stable population of cells (see 'establishing cell line'). This will require one or more passages, but may involve additional selection processes. Through such passaging and/or selection processes, the resulting 'line' attains some level of genetic stability and compositional homogeneity which is typically absent in primary cultures. Because of their relative homogeneity, ‘lines’ are capable of being characterized and stably propagated over a period of time. A new *type* of cell line can be established not only through the passaging/selection of a primary culture, but also through experimental modifications of existing lines (e.g. immortalization, stable genetic modifications, drug selection for a resistant subset, etc.). The definition provided here establishes the 'scale' of cell populations that qualify as cell lines - specifically those with a shared propagation history in culture. In this way, the 'cell line' class demarcates populations that represent what researchers actually use in the practice of science - e.g. as inputs to culturing, experimentation, and sharing. The definition is such that cell lines will exhibit important attributes. For example, they will have a relatively homogenous cell type composition as they have experienced similar selective pressures due to their continuous co-propagation. In addition, these populations can also be characterized by a passage number, again owing to their common passaging history.  As defined here, 'cell line' can refer to a population of cells in active culture, applied experimentally, or stored in a quiescent state for future use. cell line mixed adherent and suspension cell line culturing mixed suspension clusters in suspension cell line culturing cell line co-expression Oliver Note: this term needs precise definition. will consult term users later. Ba/F3 cell line co-expression Ba/F3 Stably co-expresses EpoR and JAK2V617F EpoR and JAK2V617F constructs Ba/F3 cell line EpoR and JAK2V617F co-expression CHO cell line co-expression CHO cell line co-expression of lactamase CHO Established (in your ontology) Stably transfected with Cre-beta lactamase: Cre Bla CHO cell line suspension with feeder cells cell line culturing suspension-multicell aggregates cell line culturing immortal mouse cell line cell a immortal cell line that is dervied from mouse tissue. Yue Liu, Yongqun He immortal mouse cell line immortal mouse macrophage cell line a immortal cell line that is dervied from mouse macrophage. YH immortal stem cell line cell ZX, YH a cell line that is derived from stem cell immortal mouse liver cell line a immortal cell line that is dervied from mouse liver. YH immortal Gorilla gorilla cell line cell a immortal cell line that is dervied from a Gorilla gorilla tissue. YH immortal Gorilla gorilla cell line immortal somatic stem cell line cell ZX, YH a immortal stem cell line that is derived from somatic stem cell immortal epithelial fate stem cell line cell ZX, YH a immortal somatic stem cell line that is derived from epithelial fate stem cell immortal basal cell line cell ZX, YH a immortal epithelial fate stem cell line that is derived from basal cell immortal multi fate stem cell line cell ZX, YH a immortal somatic stem cell line that is derived from multi fate stem cell immortal neuronal stem cell line cell ZX, YH a immortal multi fate stem cell line that is derived from neuronal stem cell immortal neuroblast cell line cell ZX, YH a immortal neuronal stem cell line that is derived from neuroblast immortal mesenchymal cell line cell ZX, YH a immortal multi fate stem cell line that is derived from mesenchymal cell immortal non-terminally differentiated cell line cell ZX, YH a cell line that is derived from non-terminally differentiated cell immortal non-terminally differentiated cell line immortal osteoblast cell line cell ZX, YH a immortal non-terminally differentiated cell line that is derived from osteoblast immortal osteoblast cell line immortal muscle precursor cell line cell ZX, YH a immortal non-terminally differentiated cell line that is derived from muscle precursor cell immortal muscle precursor cell line immortal myoblast cell line cell ZX, YH a immortal muscle precursor cell line that is derived from myoblast immortal myoblast cell line immortal fusion competent myoblast cell line cell ZX, YH a immortal myoblast cell line that is derived from fusion competent myoblast immortal fusion competent myoblast cell line immortal secretory cell line cell ZX, YH a cell line that is derived from secretory cell immortal secretory cell line immortal glandular epithelial cell line cell ZX, YH a immortal secretory cell line that is derived from glandular epithelial cell immortal anterior pituitary gland chromophil cell line cell ZX, YH a immortal glandular epithelial cell line cell that is derived from chromophil cell of anterior pituitary gland immortal thyrotroph cell line cell ZX, YH a immortal chromophil cell line cell of anterior pituitary gland that is derived from thyrotroph immortal pars distalis of adenohypophysis acidophil cell line cell ZX, YH a immortal chromophil cell line of anterior pituitary gland that is derived from acidophil cell of pars distalis of adenohypophysis immortal neck cell line cell ZX, YH a immortal glandular epithelial cell line that is derived from neck cell immortal glandular cell line of stomach cell ZX, YH a immortal glandular epithelial cell line that is derived from glandular cell of stomach immortal parietal cell line cell ZX, YH a immortal glandular cell line of stomach that is derived from parietal cell immortal exocrine cell line cell ZX, YH a immortal secretory cell line that is derived from exocrine cell immortal exocrine cell line immortal endocrine cell line cell ZX, YH a immortal secretory cell line that is derived from endocrine cell immortal endocrine cell line immortal mast cell line cell ZX, YH a immortal endocrine cell line that is derived from mast cell immortal mast cell line immortal neuroendocrine cell line cell ZX, YH a immortal endocrine cell line cell that is derived from neuroendocrine cell immortal Leydig cell line cell ZX, YH a immortal endocrine cell line that is derived from Leydig cell immortal Leydig cell line immortal Sertoli cell line cell ZX, YH a immortal secretory cell line cell that is derived from Sertoli cell immortal plasma cell line cell ZX, YH a immortal secretory cell line that is derived from plasma cell immortal plasma cell line immortal contractile cell line cell ZX, YH an immortal cell line cell that is derived from contractile cell immortal myofibroblast cell line cell ZX, YH a immortal contractile cell line cell that is derived from myofibroblast cell immortal muscle cell line cell ZX, YH a immortal contractile cell line cell that is derived from muscle cell immortal skeletal muscle cell line cell ZX, YH a immortal muscle cell line cell that is derived from skeletal muscle cell immortal smooth muscle cell line cell ZX, YH a immortal muscle cell line cell that is derived from smooth muscle cell immortal electrically active cell line cell ZX, YH an immortal cell line cell that is derived from electrically active cell immortal electrically responsive cell line cell ZX, YH a immortal electrically active cell line cell that is derived from electrically responsive cell immortal neuron cell line cell ZX, YH a immortal electrically responsive cell line cell that is derived from neuron immortal bipolar neuron cell line cell ZX, YH a immortal neuron cell line cell that is derived from bipolar neuron immortal ON-bipolar cell line cell ZX, YH a immortal bipolar neuron cell line cell that is derived from ON-bipolar cell immortal peripheral neuron cell line cell ZX, YH a immortal neuron cell line cell that is derived from peripheral neuron immortal stellate cell line cell ZX, YH a immortal neuron cell line cell that is derived from stellate cell immortal barrier cell line cell ZX, YH an immortal cell line cell that is derived from barrier cell immortal lining cell line cell ZX, YH an immortal barrier cell line cell that is derived from lining cell immortal mesothelial cell line cell ZX, YH a immortal lining cell line cell that is derived from mesothelial cell immortal seminiferous tubule epithelial cell line cell ZX, YH a immortal mesothelial cell line cell that is derived from seminiferous tubule epithelial cell immortal spermatocyte cell line cell ZX, YH a immortal seminiferous tubule epithelial cell line cell that is derived from spermatocyte immortal endothelial cell line cell ZX, YH a immortal lining cell line cell that is derived from endothelial cell immortal myelinating Schwann cell line cell ZX, YH a immortal barrier cell line cell that is derived from myelinating Schwann cell immortal motile cell line cell ZX, YH a cell line that is derived from motile cell immortal motile cell line immortal phagocyte cell line cell ZX, YH a immortal motile cell line that is derived from phagocyte immortal mononuclear phagocyte cell line cell ZX, YH a immortal phagocyte cell line that is derived from mononuclear phagocyte immortal macrophage cell line cell ZX, YH a immortal phagocyte cell line that is derived from macrophage immortal tissue-resident macrophage cell line cell ZX, YH a immortal macrophage cell line that is derived from tissue-resident macrophage immortal microglial cell line cell ZX, YH a immortal tissue-resident macrophage cell line that is derived from microglial cell immortal peritoneal macrophage cell line cell ZX, YH a immortal tissue-resident macrophage cell line that is derived from peritoneal macrophage immortal polygonal cell line cell ZX, YH a immortal phagocyte cell line that is derived from polygonal cell immortal polygonal cell line immortal amoeboid cell line cell ZX, YH a immortal motile cell line that is derived from amoeboid cell immortal amoeboid cell line immortal leukocyte cell line cell ZX, YH a immortal motile cell line that is derived from leukocyte immortal leukocyte cell line immortal dendritic cell line cell ZX, YH a immortal leukocyte cell line that is derived from dendritic cell immortal dendritic cell line immortal Langerhans cell line cell ZX, YH a immortal dendritic cell line that is derived from Langerhans cell immortal Langerhans cell line immortal myeloid leukocyte cell line cell ZX, YH a immortal leukocyte cell line that is derived from myeloid leukocyte immortal myeloid leukocyte cell line immortal monocyte cell line cell ZX, YH a immortal myeloid leukocyte cell line that is derived from monocyte immortal monocyte cell line immortal nongranular leukocyte cell line cell ZX, YH a immortal leukocyte cell line that is derived from nongranular leukocyte immortal nongranular leukocyte cell line immortal lymphocyte cell line cell ZX, YH a immortal nongranular leukocyte cell line that is derived from lymphocyte immortal lymphocyte cell line immortal T cell line cell ZX, YH a immortal lymphocyte cell line that is derived from T cell immortal T cell line immortal alpha-beta T cell line cell ZX, YH a immortal T cell line that is derived from alpha-beta T cell immortal alpha-beta T cell line immortal immature alpha-beta T cell line cell ZX, YH a immortal alpha-beta T cell line that is derived from immature alpha-beta T cell immortal immature alpha-beta T cell line immortal double-positive, alpha-beta thymocyte cell line cell ZX, YH a immortal immature alpha-beta T cell line that is derived from double-positive, alpha-beta thymocyte immortal double-positive, alpha-beta thymocyte cell line immortal mature alpha-beta T cell line cell ZX, YH a immortal alpha-beta T cell line that is derived from mature alpha-beta T cell immortal mature alpha-beta T cell line immortal CD4-positive, CD25-positive, alpha-beta regulatory T cell line cell ZX, YH a immortal mature alpha-beta T cell line that is derived from CD4-positive, CD25-positive, alpha-beta regulatory T cell immortal CD4-positive, CD25-positive, alpha-beta regulatory T cell line immortal induced T-regulatory cell line cell ZX, YH a immortal CD4-positive, CD25-positive, alpha-beta regulatory T cell line that is derived from induced T-regulatory cell immortal induced T-regulatory cell line immortal mature T cell line cell ZX, YH a immortal T cell line that is derived from mature T cell immortal mature T cell line immortal helper T cell line cell ZX, YH a immortal mature T cell line that is derived from helper T cell immortal helper T cell line immortal immature T cell line cell ZX, YH a immortal T cell line that is derived from immature T cell immortal immature T cell line immortal B cell line cell ZX, YH a immortal lymphocyte cell line that is derived from B cell immortal B cell line immortal B-cell line cell immortal precursor B cell line cell ZX, YH a immortal B cell line that is derived from precursor B cell immortal precursor B cell line immortal natural killer cell line cell ZX, YH a immortal lymphocyte cell line that is derived from natural killer cell immortal natural killer cell line immortal single nucleate cell line cell ZX, YH a cell line that is derived from single nucleate cell immortal single nucleate cell line immortal multinucleate cell line cell ZX, YH a cell line that is derived from multinucleate cell immortal multinucleate cell line immortal eukaryotic cell line cell ZX, YH a immortal cell line cell that is derived from eukaryotic cell immortal vegetative cell line (sensu Mycetozoa) cell ZX, YH a immortal eukaryotic cell line that is derived from vegetative cell (sensu Mycetozoa) immortal vegetative cell line (sensu Mycetozoa) immortal aggregate cell line cell ZX, YH a immortal vegetative cell line (sensu Mycetozoa) that is derived from aggregate cell immortal aggregate cell line immortal anterior like cell line cell ZX, YH a immortal vegetative cell line (sensu Mycetozoa) that is derived from anterior like cell immortal anterior like cell line immortal animal cell line cell ZX, YH a immortal eukaryotic cell line that is derived from animal cell immortal animal cell line immortal epithelial cell line cell ZX, YH a immortal animal cell line that is derived from epithelial cell immortal duct epithelial cell line cell ZX, YH a immortal epithelial cell line that is derived from duct epithelial cell immortal columnar/cuboidal epithelial cell line cell ZX, YH a immortal epithelial cell line that is derived from columnar/cuboidal epithelial cell immortal neurecto-epithelial cell line cell ZX, YH a immortal columnar/cuboidal epithelial cell line that is derived from neurecto-epithelial cell immortal neurecto-epithelial cell line immortal melanocyte cell line cell ZX, YH a immortal neurecto-epithelial cell line that is derived from melanocyte immortal pigmented epithelial cell line cell ZX, YH a immortal neurecto-epithelial cell line that is derived from pigmented epithelial cell immortal pigmented epithelial cell line immortal squamous epithelial cell line cell ZX, YH a immortal epithelial cell line that is derived from squamous epithelial cell immortal stratified squamous epithelial cell line cell ZX, YH a immortal squamous epithelial cell line that is derived from stratified squamous epithelial cell immortal keratinizing barrier epithelial cell line cell ZX, YH a immortal stratified squamous epithelial cell line that is derived from keratinizing barrier epithelial cell immortal keratinocyte cell line cell ZX, YH a immortal keratinizing barrier epithelial cell line that is derived from keratinocyte immortal epidermal cell line cell ZX, YH a immortal squamous epithelial cell line that is derived from epidermal cell immortal stratified epithelial cell line cell ZX, YH a immortal epithelial cell line that is derived from stratified epithelial cell immortal epithelial cell line of lung cell ZX, YH a immortal epithelial cell line that is derived from epithelial cell of lung immortal epithelial cell line of pancreas cell ZX, YH a immortal epithelial cell line that is derived from epithelial cell of pancreas immortal ecto-epithelial cell line cell ZX, YH a immortal epithelial cell line that is derived from ecto-epithelial cell immortal meso-epithelial cell line cell ZX, YH a immortal epithelial cell line that is derived from meso-epithelial cell immortal meso-epithelial cell line immortal extraembryonic cell line cell ZX, YH a immortal animal cell line that is derived from extraembryonic cell immortal trophoblast cell line cell ZX, YH a immortal extraembryonic cell line that is derived from trophoblast cell immortal trophoblast cell line immortal hematopoietic cell line cell ZX, YH a immortal animal cell line that is derived from hematopoietic cell immortal hematopoietic cell line immortal megakaryocyte-erythroid progenitor cell line cell ZX, YH a immortal hematopoietic cell line that is derived from megakaryocyte-erythroid progenitor cell immortal megakaryocyte-erythroid progenitor cell line immortal blood cell line cell ZX, YH a immortal hematopoietic cell line that is derived from blood cell immortal blood cell line immortal myeloid cell line cell ZX, YH a immortal hematopoietic cell line that is derived from myeloid cell immortal myeloid cell line immortal erythroblast cell line cell ZX, YH a immortal myeloid cell line that is derived from erythroblast immortal erythroblast cell line immortal hematopoietic lineage restricted progenitor cell line cell ZX, YH a immortal hematopoietic cell line that is derived from hematopoietic lineage restricted progenitor cell immortal hematopoietic lineage restricted progenitor cell line immortal pro-B cell line cell ZX, YH a immortal hematopoietic lineage restricted progenitor cell line that is derived from pro-B cell immortal pro-B cell line immortal myeloblast cell line cell ZX, YH a immortal hematopoietic lineage restricted progenitor cell line that is derived from myeloblast immortal myeloblast cell line immortal basophilic myeloblast cell line cell ZX, YH a immortal myeloblast cell line that is derived from basophilic myeloblast immortal basophilic myeloblast cell line immortal neural cell line cell ZX, YH a immortal animal cell line that is derived from neural cell immortal neural cell line immortal glial cell line cell ZX, YH a immortal neural cell line that is derived from glial cell immortal glial cell line immortal glial cell line (sensu Vertebrata) cell ZX, YH a immortal glial cell line that is derived from glial cell (sensu Vertebrata) immortal glial cell line (sensu Vertebrata) immortal astrocyte cell line cell ZX, YH a immortal glial cell line (sensu Vertebrata) that is derived from astrocyte immortal astrocyte cell line immortal connective tissue cell line cell ZX, YH a immortal animal cell line that is derived from connective tissue cell immortal fibroblast cell line cell ZX, YH a immortal connective tissue cell line that is derived from fibroblast immortal fibroblast cell line immortal stromal cell line cell ZX, YH a immortal connective tissue cell line that is derived from stromal cell immortal stromal cell line immortal stuff accumulating cell line cell ZX, YH a cell line that is derived from stuff accumulating cell immortal parenchymal cell line cell ZX, YH a cell line that is derived from parenchymal cell immortal parenchymal cell line immortal nucleate cell line cell ZX, YH a cell line that is derived from nucleate cell immortal nucleate cell line immortal somatic cell line cell ZX, YH a cell line that is derived from somatic cell HeLa derived cell line cell a immortal epithelial cell line cell that is derived from HeLa cell Yongqun He hybridoma cell line cell an immortal cell line cell that is established by fusing a specific antibody-producing B cell with a myeloma (B cell cancer) cell that is selected for its ability to produce a monoclonal antibody. The production of monoclonal antibodies using the hybridoma technology was invented by Cesar Milstein and Georges J. F. Köhler in 1975. They shared the Nobel Prize of 1984 for Medicine and Physiology with Niels Kaj Jerne, who made other contributions to immunology. Yongqun He WEB: http://en.wikipedia.org/wiki/Hybridoma_technology cell passageble capability Yongqun He a function of a cell that can be passaged in culture medium without death or genetic change. cell line lineage This term will be a subclass of BFO 2 'history'. The BFO 2 'history' term will be imported to CLO after the BFO 2 is finalized. Yongqun He cell line lineage is a history of the development of a cell line. The cell line lineage may include the original cell type from a tissue and organism that derives the cell line cell. It may also include the cell line passage and cell culturing information. Coriell cell line cell a cell line cell that is in the Coriell cell line repositories. SS, YH, UV, SS RIKEN Cell Bank cell SS, YH, UV, SS a cell line cell that is in the RIKEN Cell bank cloned cell line MHB 2013-07-16: This should be made into a defined class, using an axiom referencing a clonal cell expansion process, or a clonal cell line creation process. REO: REO_0000397 YH, SS, MHB A cell line comprised of cells which can all be traced back to a single ancestor cell, and which therefore can be treated as identical. This can be used to study just the progeny of single cells. clonal cell line immortal peripheral vein-derived B cell line cell An immortal B cell line cell that derives from peripheral vein. Yue Liu, Yongqun He immortal organism part-derived cell line cell An immortal cell line cell that derives from organism part. Yue Liu, Yongqun He immortal arm-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from arm. Yue Liu, Yongqun He immortal organism part-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from organism part. Yue Liu, Yongqun He immortal tunica albuginea of testis-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from tunica albuginea of testis. Yue Liu, Yongqun He immortal amniotic fluid-derived cell line cell An immortal cell line cell that derives from amniotic fluid. Yue Liu, Yongqun He immortal peripheral vein-derived T cell line cell An immortal T cell line cell that derives from peripheral vein. Yue Liu, Yongqun He immortal animal ovary-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from animal ovary. Yue Liu, Yongqun He immortal skin-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from skin. Yue Liu, Yongqun He immortal organism part-derived keratinocyte cell line cell An immortal keratinocyte cell line cell that derives from organism part. Yue Liu, Yongqun He immortal testis-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from testis. Yue Liu, Yongqun He immortal liver-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from liver. Yue Liu, Yongqun He immortal lung-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from lung. Yue Liu, Yongqun He immortal embryo-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from embryo. Yue Liu, Yongqun He immortal thoracic aorta-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from thoracic aorta. Yue Liu, Yongqun He immortal gum-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from gum. Yue Liu, Yongqun He immortal digit-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from digit. Yue Liu, Yongqun He immortal skin-derived cell line cell An immortal cell line cell that derives from skin. Yue Liu, Yongqun He immortal trachealis-derived smooth muscle cell line cell An immortal smooth muscle cell line cell that derives from trachealis. Yue Liu, Yongqun He immortal neck-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from neck. Yue Liu, Yongqun He immortal umbilical cord-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from umbilical cord. Yue Liu, Yongqun He immortal abdominal aorta-derived endothelial cell line cell An immortal endothelial cell line cell that derives from abdominal aorta. Yue Liu, Yongqun He immortal iliac vein-derived endothelial cell line cell An immortal endothelial cell line cell that derives from iliac vein. Yue Liu, Yongqun He immortal common iliac artery-derived endothelial cell line cell An immortal endothelial cell line cell that derives from common iliac artery. Yue Liu, Yongqun He immortal gonad-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from gonad. Yue Liu, Yongqun He immortal amnion-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from amnion. Yue Liu, Yongqun He immortal thigh-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from thigh. Yue Liu, Yongqun He immortal umbilical vein-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from umbilical vein. Yue Liu, Yongqun He immortal vasculature-derived cell line cell An immortal cell line cell that derives from vasculature. Yue Liu, Yongqun He immortal spleen-derived cell line cell An immortal cell line cell that derives from spleen. Yue Liu, Yongqun He immortal multi-cellular organism-derived cell line cell An immortal cell line cell that derives from multi-cellular organism. Yue Liu, Yongqun He immortal fetal membrane-derived cell line cell An immortal cell line cell that derives from fetal membrane. Yue Liu, Yongqun He immortal dento-alveolar joint-derived cell line cell An immortal cell line cell that derives from dento-alveolar joint. Yue Liu, Yongqun He immortal mixed endoderm/mesoderm-derived structure-derived cell line cell An immortal cell line cell that derives from mixed endoderm/mesoderm-derived structure. Yue Liu, Yongqun He immortal late embryo-derived cell line cell An immortal cell line cell that derives from late embryo. Yue Liu, Yongqun He immortal muscle spindle-derived cell line cell An immortal cell line cell that derives from muscle spindle. Yue Liu, Yongqun He immortal thymus-derived cell line cell An immortal cell line cell that derives from thymus. Yue Liu, Yongqun He immortal amnion-derived cell line cell An immortal cell line cell that derives from amnion. Yue Liu, Yongqun He immortal tongue-derived cell line cell An immortal cell line cell that derives from tongue. Yue Liu, Yongqun He immortal lung-derived cell line cell An immortal cell line cell that derives from pair of lungs. Yue Liu, Yongqun He immortal kidney-derived cell line cell An immortal cell line cell that derives from kidney. Yue Liu, Yongqun He immortal abdominal cavity-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from abdominal cavity. Yue Liu, Yongqun He immortal thoracic aorta-derived smooth muscle cell line cell An immortal smooth muscle cell line cell that derives from thoracic aorta. Yue Liu, Yongqun He immortal placenta-derived cell line cell An immortal cell line cell that derives from placenta. Yue Liu, Yongqun He immortal pericardium-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from pericardium. Yue Liu, Yongqun He immortal embryo-derived cell line cell An immortal cell line cell that derives from embryo. Yue Liu, Yongqun He immortal foetal structure-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from foetal structure. Yue Liu, Yongqun He immortal external genitalia-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from external genitalia. Yue Liu, Yongqun He immortal prostate gland-derived cell line cell An immortal cell line cell that derives from prostate gland. Yue Liu, Yongqun He immortal septum of telencephalon-derived cell line cell An immortal cell line cell that derives from septum of telencephalon. Yue Liu, Yongqun He immortal larva-derived cell line cell An immortal cell line cell that derives from larva. Yue Liu, Yongqun He immortal area X-derived cell line cell An immortal cell line cell that derives from area X. Yue Liu, Yongqun He immortal somatic nervous system-derived cell line cell An immortal cell line cell that derives from somatic nervous system. Yue Liu, Yongqun He immortal lymph-derived cell line cell An immortal cell line cell that derives from lymph. Yue Liu, Yongqun He immortal thoracic aorta-derived endothelial cell line cell An immortal endothelial cell line cell that derives from thoracic aorta. Yue Liu, Yongqun He immortal liver-derived cell line cell An immortal cell line cell that derives from liver. Yue Liu, Yongqun He immortal colon-derived cell line cell An immortal cell line cell that derives from colon. Yue Liu, Yongqun He immortal caecum-derived cell line cell An immortal cell line cell that derives from caecum. Yue Liu, Yongqun He immortal pancreas-derived cell line cell An immortal cell line cell that derives from pancreas. Yue Liu, Yongqun He immortal brain-derived cell line cell An immortal cell line cell that derives from brain. Yue Liu, Yongqun He immortal tail-derived cell line cell An immortal cell line cell that derives from tail. Yue Liu, Yongqun He immortal collecting duct of renal tubule-derived cell line cell An immortal cell line cell that derives from collecting duct of renal tubule. Yue Liu, Yongqun He immortal mesonephros-derived cell line cell An immortal cell line cell that derives from mesonephros. Yue Liu, Yongqun He immortal female gonad-derived cell line cell An immortal cell line cell that derives from female gonad. Yue Liu, Yongqun He immortal chorion-derived cell line cell An immortal cell line cell that derives from chorion. Yue Liu, Yongqun He immortal lymphoid follicle-derived cell line cell An immortal cell line cell that derives from lymphoid follicle. Yue Liu, Yongqun He immortal leg-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from leg. Yue Liu, Yongqun He immortal limb/fin-derived cell line cell An immortal cell line cell that derives from limb/fin. Yue Liu, Yongqun He immortal testis-derived cell line cell An immortal cell line cell that derives from testis. Yue Liu, Yongqun He immortal stomach-derived cell line cell An immortal cell line cell that derives from stomach. Yue Liu, Yongqun He immortal endothelium-derived cell line cell An immortal cell line cell that derives from endothelium. Yue Liu, Yongqun He immortal foreskin-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from foreskin. Yue Liu, Yongqun He immortal achilles tendon-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from achilles tendon. Yue Liu, Yongqun He immortal bone element-derived cell line cell An immortal cell line cell that derives from bone element. Yue Liu, Yongqun He immortal thyroid gland-derived cell line cell An immortal cell line cell that derives from thyroid gland. Yue Liu, Yongqun He immortal urinary bladder-derived cell line cell An immortal cell line cell that derives from urinary bladder. Yue Liu, Yongqun He immortal acetabular part of hip bone-derived cell line cell An immortal cell line cell that derives from acetabular part of hip bone. Yue Liu, Yongqun He immortal breast-derived cell line cell An immortal cell line cell that derives from breast. Yue Liu, Yongqun He immortal epithelium-derived cell line cell An immortal cell line cell that derives from epithelium. Yue Liu, Yongqun He immortal comma-shaped body-derived cell line cell An immortal cell line cell that derives from comma-shaped body. Yue Liu, Yongqun He immortal supra-orbital vein-derived cell line cell An immortal cell line cell that derives from supra-orbital vein. Yue Liu, Yongqun He immortal ear-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from ear. Yue Liu, Yongqun He immortal inguinal region-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from inguinal region. Yue Liu, Yongqun He immortal mesothelium-derived cell line cell An immortal cell line cell that derives from mesothelium. Yue Liu, Yongqun He immortal uterus-derived cell line cell An immortal cell line cell that derives from uterus. Yue Liu, Yongqun He immortal endometrium-derived cell line cell An immortal cell line cell that derives from endometrium. Yue Liu, Yongqun He immortal uterine cervix-derived cell line cell An immortal cell line cell that derives from uterine cervix. Yue Liu, Yongqun He immortal heart-derived cell line cell An immortal cell line cell that derives from heart. Yue Liu, Yongqun He immortal pituitary gland-derived cell line cell An immortal cell line cell that derives from pituitary gland. Yue Liu, Yongqun He immortal gill-derived cell line cell An immortal cell line cell that derives from gill. Yue Liu, Yongqun He immortal follicular fluid-derived cell line cell An immortal cell line cell that derives from follicular fluid. Yue Liu, Yongqun He immortal eye-derived cell line cell An immortal cell line cell that derives from eye. Yue Liu, Yongqun He immortal organism part-derived plasma cell line cell An immortal plasma cell line cell that derives from organism part. Yue Liu, Yongqun He immortal floating rib-derived cell line cell An immortal cell line cell that derives from floating rib. Yue Liu, Yongqun He immortal mammary gland-derived cell line cell An immortal cell line cell that derives from mammary gland. Yue Liu, Yongqun He immortal thorax-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from thorax. Yue Liu, Yongqun He immortal paired fin-derived cell line cell An immortal cell line cell that derives from paired fin. Yue Liu, Yongqun He immortal neural nucleus-derived cell line cell An immortal cell line cell that derives from neural nucleus. Yue Liu, Yongqun He immortal Ammon's horn-derived cell line cell An immortal cell line cell that derives from Ammon's horn. Yue Liu, Yongqun He immortal bone marrow-derived cell line cell An immortal cell line cell that derives from bone marrow. Yue Liu, Yongqun He immortal islet of Langerhans-derived cell line cell An immortal cell line cell that derives from islet of Langerhans. Yue Liu, Yongqun He immortal pyramid of medulla oblongata-derived cell line cell An immortal cell line cell that derives from pyramid of medulla oblongata. Yue Liu, Yongqun He mouse x mouse hybridoma cell line cell most hybridoma cell line cells are mouse x mouse Yongqun He a hybridoma cell line cell that is established by fusing cells from two mice. immortal uterine cervix-derived epithelial cell line cell An immortal epithelial cell line cell that derives from uterine cervix. Yue Liu, Yongqun He immortal ileocecal junction-derived cell line cell An immortal cell line cell that derives from ileocecal junction. Yue Liu, Yongqun He immortal compact bone-derived cell line cell An immortal cell line cell that derives from compact bone. Yue Liu, Yongqun He immortal abdominal aorta-derived cell line cell An immortal cell line cell that derives from abdominal aorta. Yue Liu, Yongqun He immortal bronchus-derived cell line cell An immortal cell line cell that derives from bronchus. Yue Liu, Yongqun He immortal iliac artery-derived cell line cell An immortal cell line cell that derives from iliac artery. Yue Liu, Yongqun He immortal synovial membrane of synovial joint-derived cell line cell An immortal cell line cell that derives from synovial membrane of synovial joint. Yue Liu, Yongqun He immortal iliac vein-derived cell line cell An immortal cell line cell that derives from iliac vein. Yue Liu, Yongqun He immortal vagina-derived cell line cell An immortal cell line cell that derives from vagina. Yue Liu, Yongqun He immortal larynx-derived cell line cell An immortal cell line cell that derives from larynx. Yue Liu, Yongqun He immortal inferior cervical ganglion-derived cell line cell An immortal cell line cell that derives from inferior cervical ganglion. Yue Liu, Yongqun He immortal esophagus-derived cell line cell An immortal cell line cell that derives from esophagus. Yue Liu, Yongqun He immortal femoral artery-derived cell line cell An immortal cell line cell that derives from femoral artery. Yue Liu, Yongqun He immortal prepuce of penis-derived cell line cell An immortal cell line cell that derives from prepuce of penis. Yue Liu, Yongqun He immortal gingival epithelium-derived cell line cell An immortal cell line cell that derives from gingival epithelium. Yue Liu, Yongqun He immortal gingiva-derived cell line cell An immortal cell line cell that derives from gingiva. Yue Liu, Yongqun He immortal mouth-derived cell line cell An immortal cell line cell that derives from mouth. Yue Liu, Yongqun He immortal peripheral vein-derived cell line cell An immortal cell line cell that derives from peripheral vein. Yue Liu, Yongqun He immortal peritoneum-derived cell line cell An immortal cell line cell that derives from peritoneum. Yue Liu, Yongqun He immortal round window-derived cell line cell An immortal cell line cell that derives from round window. Yue Liu, Yongqun He immortal conjunctiva structure-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from conjunctiva structure. Yue Liu, Yongqun He immortal intestine-derived cell line cell An immortal cell line cell that derives from intestine. Yue Liu, Yongqun He immortal rectum-derived cell line cell An immortal cell line cell that derives from rectum. Yue Liu, Yongqun He immortal pulmonary vein-derived cell line cell An immortal cell line cell that derives from pulmonary vein. Yue Liu, Yongqun He immortal buttock-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from buttock. Yue Liu, Yongqun He immortal tonsil-derived cell line cell An immortal cell line cell that derives from tonsil. Yue Liu, Yongqun He immortal umbilicus-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from umbilicus. Yue Liu, Yongqun He immortal posterior commissure-derived cell line cell An immortal cell line cell that derives from posterior commissure. Yue Liu, Yongqun He immortal soft palate-derived cell line cell An immortal cell line cell that derives from soft palate. Yue Liu, Yongqun He immortal adrenal gland-derived cell line cell An immortal cell line cell that derives from adrenal gland. Yue Liu, Yongqun He immortal pronephros-derived cell line cell An immortal cell line cell that derives from pronephros. Yue Liu, Yongqun He immortal organism part-derived smooth muscle cell line cell An immortal smooth muscle cell line cell that derives from organism part. Yue Liu, Yongqun He immortal sublingual artery-derived cell line cell An immortal cell line cell that derives from sublingual artery. Yue Liu, Yongqun He immortal aorta-derived cell line cell An immortal cell line cell that derives from aorta. Yue Liu, Yongqun He immortal ligament-derived cell line cell An immortal cell line cell that derives from ligament. Yue Liu, Yongqun He immortal uterus-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from uterus. Yue Liu, Yongqun He immortal cerebral lobe-derived cell line cell An immortal cell line cell that derives from cerebral lobe. Yue Liu, Yongqun He immortal squamous part of temporal bone-derived cell line cell An immortal cell line cell that derives from squamous part of temporal bone. Yue Liu, Yongqun He immortal pronephros-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from pronephros. Yue Liu, Yongqun He immortal mucosa-derived cell line cell An immortal cell line cell that derives from mucosa. Yue Liu, Yongqun He immortal epidermis-derived cell line cell An immortal cell line cell that derives from epidermis. Yue Liu, Yongqun He immortal submandibular gland-derived cell line cell An immortal cell line cell that derives from submandibular gland. Yue Liu, Yongqun He immortal lung-derived mesothelial cell line cell An immortal mesothelial cell line cell that derives from lung. Yue Liu, Yongqun He immortal eye structure-derived epithelial cell line cell An immortal epithelial cell line cell that derives from eye structure. Yue Liu, Yongqun He immortal hip-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from hip. Yue Liu, Yongqun He immortal prostate epithelium-derived cell line cell An immortal cell line cell that derives from prostate epithelium. Yue Liu, Yongqun He immortal retinal neural layer-derived cell line cell An immortal cell line cell that derives from retinal neural layer. Yue Liu, Yongqun He immortal ureter-derived cell line cell An immortal cell line cell that derives from ureter. Yue Liu, Yongqun He immortal iliac vein-derived smooth muscle cell line cell An immortal smooth muscle cell line cell that derives from iliac vein. Yue Liu, Yongqun He immortal common iliac artery-derived smooth muscle cell line cell An immortal smooth muscle cell line cell that derives from common iliac artery. Yue Liu, Yongqun He immortal mammary gland-derived keratinocyte cell line cell An immortal keratinocyte cell line cell that derives from mammary gland. Yue Liu, Yongqun He immortal umbilical vein-derived endothelial cell line cell An immortal endothelial cell line cell that derives from umbilical vein. Yue Liu, Yongqun He immortal scalp-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from scalp. Yue Liu, Yongqun He immortal skeletal muscle-derived myoblast cell line cell An immortal myoblast cell line cell that derives from skeletal muscle. Yue Liu, Yongqun He immortal organism part-derived endothelial cell line cell An immortal endothelial cell line cell that derives from organism part. Yue Liu, Yongqun He immortal sacrum-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from sacrum. Yue Liu, Yongqun He immortal shoulder-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from shoulder. Yue Liu, Yongqun He immortal placenta-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from placenta. Yue Liu, Yongqun He immortal dermis-derived cell line cell An immortal cell line cell that derives from dermis. Yue Liu, Yongqun He immortal cornea-derived cell line cell An immortal cell line cell that derives from cornea. Yue Liu, Yongqun He immortal mammalian vulva-derived cell line cell An immortal cell line cell that derives from mammalian vulva. Yue Liu, Yongqun He immortal spherical lensed eye-derived cell line cell An immortal cell line cell that derives from spherical lensed eye. Yue Liu, Yongqun He immortal ileum-derived cell line cell An immortal cell line cell that derives from ileum. Yue Liu, Yongqun He immortal cervix-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from cervix. Yue Liu, Yongqun He immortal rhomboid-derived myoblast cell line cell An immortal myoblast cell line cell that derives from rhomboid. Yue Liu, Yongqun He immortal abdominal cavity-derived cell line cell An immortal cell line cell that derives from abdominal cavity. Yue Liu, Yongqun He immortal umbilical vein-derived cell line cell An immortal cell line cell that derives from umbilical vein. Yue Liu, Yongqun He immortal duodenum-derived cell line cell An immortal cell line cell that derives from duodenum. Yue Liu, Yongqun He immortal connective tissue-derived cell line cell An immortal cell line cell that derives from connective tissue. Yue Liu, Yongqun He immortal parotid gland-derived cell line cell An immortal cell line cell that derives from parotid gland. Yue Liu, Yongqun He immortal ischium-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from ischium. Yue Liu, Yongqun He immortal buttock-derived cell line cell An immortal cell line cell that derives from buttock. Yue Liu, Yongqun He immortal anatomical cluster-derived cell line cell An immortal cell line cell that derives from anatomical cluster. Yue Liu, Yongqun He immortal thigh-derived cell line cell An immortal cell line cell that derives from thigh. Yue Liu, Yongqun He immortal chordate pharynx-derived cell line cell An immortal cell line cell that derives from chordate pharynx. Yue Liu, Yongqun He immortal retina-derived cell line cell An immortal cell line cell that derives from retina. Yue Liu, Yongqun He immortal yolk sac-derived cell line cell An immortal cell line cell that derives from yolk sac. Yue Liu, Yongqun He immortal nasal concha-derived cell line cell An immortal cell line cell that derives from nasal concha. Yue Liu, Yongqun He immortal arm-derived cell line cell An immortal cell line cell that derives from arm. Yue Liu, Yongqun He immortal sacrum-derived cell line cell An immortal cell line cell that derives from sacrum. Yue Liu, Yongqun He immortal conjunctiva-derived cell line cell An immortal cell line cell that derives from conjunctiva. Yue Liu, Yongqun He immortal trachea-derived cell line cell An immortal cell line cell that derives from trachea. Yue Liu, Yongqun He immortal respiration organ-derived cell line cell An immortal cell line cell that derives from respiration organ. Yue Liu, Yongqun He immortal renal glomerulus-derived cell line cell An immortal cell line cell that derives from renal glomerulus. Yue Liu, Yongqun He immortal nephron tubule-derived cell line cell An immortal cell line cell that derives from nephron tubule. Yue Liu, Yongqun He immortal sternum-derived cell line cell An immortal cell line cell that derives from sternum. Yue Liu, Yongqun He immortal hypodermis-derived cell line cell An immortal cell line cell that derives from hypodermis. Yue Liu, Yongqun He immortal proximal tubule-derived cell line cell An immortal cell line cell that derives from proximal tubule. Yue Liu, Yongqun He immortal mucosa of vagina-derived cell line cell An immortal cell line cell that derives from mucosa of vagina. Yue Liu, Yongqun He immortal endocervix-derived cell line cell An immortal cell line cell that derives from endocervix. Yue Liu, Yongqun He immortal organism part-derived mesothelial cell line cell An immortal mesothelial cell line cell that derives from organism part. Yue Liu, Yongqun He immortal human peripheral vein-derived B cell line cell An immortal peripheral vein-derived B cell line cell that derives from human. Yue Liu, Yongqun He immortal pulmonary nerve plexus-derived cell line cell An immortal cell line cell that derives from pulmonary nerve plexus. Yue Liu, Yongqun He immortal pelvic fin-derived cell line cell An immortal cell line cell that derives from pelvic fin. Yue Liu, Yongqun He immortal right ureter-derived cell line cell An immortal cell line cell that derives from right ureter. Yue Liu, Yongqun He immortal superior rostral sulcus-derived cell line cell An immortal cell line cell that derives from superior rostral sulcus. Yue Liu, Yongqun He immortal gonad-derived cell line cell An immortal cell line cell that derives from gonad. Yue Liu, Yongqun He immortal cornea structure-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from cornea structure. Yue Liu, Yongqun He immortal glomerular capsule-derived cell line cell An immortal cell line cell that derives from glomerular capsule. Yue Liu, Yongqun He immortal nasal vestibule-derived cell line cell An immortal cell line cell that derives from nasal vestibule. Yue Liu, Yongqun He immortal adrenal cortex-derived cell line cell An immortal cell line cell that derives from adrenal cortex. Yue Liu, Yongqun He immortal 16914-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from 16914. Yue Liu, Yongqun He immortal organism part-derived epithelial cell line cell An immortal epithelial cell line cell that derives from organism part. Yue Liu, Yongqun He immortal axilla-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from axilla. Yue Liu, Yongqun He immortal pulmonary artery-derived endothelial cell line cell An immortal endothelial cell line cell that derives from pulmonary artery. Yue Liu, Yongqun He immortal pulmonary artery-derived smooth muscle cell line cell An immortal smooth muscle cell line cell that derives from pulmonary artery. Yue Liu, Yongqun He immortal retina structure-derived epithelial cell line cell An immortal epithelial cell line cell that derives from retina structure. Yue Liu, Yongqun He immortal calf-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from calf. Yue Liu, Yongqun He immortal nose structure-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from nose structure. Yue Liu, Yongqun He immortal carotid artery-derived smooth muscle cell line cell An immortal smooth muscle cell line cell that derives from carotid artery. Yue Liu, Yongqun He immortal brain-derived fibroblast cell line cell An immortal fibroblast cell line cell that derives from brain. Yue Liu, Yongqun He immortal chimpanzee peripheral vein-derived B cell line cell An immortal peripheral vein-derived B cell line cell that derives from chimpanzee. Yue Liu, Yongqun He immortal human arm-derived fibroblast cell line cell An immortal arm-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human organism part-derived fibroblast cell line cell An immortal organism part-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal cattle organism part-derived fibroblast cell line cell An immortal organism part-derived fibroblast cell line cell that derives from cattle. Yue Liu, Yongqun He immortal human tunica albuginea of testis-derived fibroblast cell line cell An immortal tunica albuginea of testis-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human amniotic fluid-derived cell line cell An immortal amniotic fluid-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human peripheral vein-derived T cell line cell An immortal peripheral vein-derived T cell line cell that derives from human. Yue Liu, Yongqun He immortal rat organism part-derived cell line cell An immortal organism part-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal chimpanzee organism part-derived fibroblast cell line cell An immortal organism part-derived fibroblast cell line cell that derives from chimpanzee. Yue Liu, Yongqun He immortal Chinese hamster ovary-derived fibroblast cell line cell An immortal animal ovary-derived fibroblast cell line cell that derives from Chinese hamster. Yue Liu, Yongqun He immortal Bornean orangutan skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from Bornean orangutan. Yue Liu, Yongqun He immortal pig-tailed macaque skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from pig-tailed macaque. Yue Liu, Yongqun He immortal Kenya baboon skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from Kenya baboon. Yue Liu, Yongqun He immortal long-tailed macaque organism part-derived cell line cell An immortal organism part-derived cell line cell that derives from long-tailed macaque. Yue Liu, Yongqun He immortal pig-tailed macaque organism part-derived keratinocyte cell line cell An immortal organism part-derived keratinocyte cell line cell that derives from pig-tailed macaque. Yue Liu, Yongqun He immortal long-tailed macaque organism part-derived keratinocyte cell line cell An immortal organism part-derived keratinocyte cell line cell that derives from long-tailed macaque. Yue Liu, Yongqun He immortal human testis-derived fibroblast cell line cell An immortal testis-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal pygmy chimpanzee skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from pygmy chimpanzee. Yue Liu, Yongqun He immortal human liver-derived fibroblast cell line cell An immortal liver-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal red-bellied lemur skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from red-bellied lemur. Yue Liu, Yongqun He immortal black lemur skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from black lemur. Yue Liu, Yongqun He immortal Kenya baboon organism part-derived keratinocyte cell line cell An immortal organism part-derived keratinocyte cell line cell that derives from Kenya baboon. Yue Liu, Yongqun He immortal variegated lemur skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from variegated lemur. Yue Liu, Yongqun He immortal small-eared galago skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from small-eared galago. Yue Liu, Yongqun He immortal western gorilla skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from western gorilla. Yue Liu, Yongqun He immortal Angolan colobus skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from Angolan colobus. Yue Liu, Yongqun He immortal mouse organism part-derived fibroblast cell line cell An immortal organism part-derived fibroblast cell line cell that derives from mouse. Yue Liu, Yongqun He immortal Colobus guereza skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from Colobus guereza. Yue Liu, Yongqun He immortal pygmy chimpanzee peripheral vein-derived B cell line cell An immortal peripheral vein-derived B cell line cell that derives from pygmy chimpanzee. Yue Liu, Yongqun He immortal Allen's swamp monkey skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from Allen's swamp monkey. Yue Liu, Yongqun He immortal human lung-derived fibroblast cell line cell An immortal lung-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal mongoose lemur skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from mongoose lemur. Yue Liu, Yongqun He immortal Ring-tailed lemur skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from Ring-tailed lemur. Yue Liu, Yongqun He immortal chimpanzee skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from chimpanzee. Yue Liu, Yongqun He immortal rhesus macaque skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from rhesus macaque. Yue Liu, Yongqun He immortal black-handed spider monkey skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from black-handed spider monkey. Yue Liu, Yongqun He immortal Chinese hamster embryo-derived fibroblast cell line cell An immortal embryo-derived fibroblast cell line cell that derives from Chinese hamster. Yue Liu, Yongqun He immortal rat thoracic aorta-derived fibroblast cell line cell An immortal thoracic aorta-derived fibroblast cell line cell that derives from rat. Yue Liu, Yongqun He immortal Charles Island giant tortoise skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from Charles Island giant tortoise. Yue Liu, Yongqun He immortal rat testis-derived fibroblast cell line cell An immortal testis-derived fibroblast cell line cell that derives from rat. Yue Liu, Yongqun He immortal human gum-derived fibroblast cell line cell An immortal gum-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse organism part-derived cell line cell An immortal organism part-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human digit-derived fibroblast cell line cell An immortal digit-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human skin-derived cell line cell An immortal skin-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal Indian muntjac organism part-derived fibroblast cell line cell An immortal organism part-derived fibroblast cell line cell that derives from Indian muntjac. Yue Liu, Yongqun He immortal human organism part-derived cell line cell An immortal organism part-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal European rabbit, rabbit trachealis-derived smooth muscle cell line cell An immortal trachealis-derived smooth muscle cell line cell that derives from European rabbit, rabbit. Yue Liu, Yongqun He immortal human neck-derived fibroblast cell line cell An immortal neck-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human umbilical cord-derived fibroblast cell line cell An immortal umbilical cord-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal lesser panda skin-derived fibroblast cell line cell An immortal skin-derived fibroblast cell line cell that derives from lesser panda. Yue Liu, Yongqun He immortal human abdominal aorta-derived endothelial cell line cell An immortal abdominal aorta-derived endothelial cell line cell that derives from human. Yue Liu, Yongqun He immortal human iliac vein-derived endothelial cell line cell An immortal iliac vein-derived endothelial cell line cell that derives from human. Yue Liu, Yongqun He immortal human common iliac artery-derived endothelial cell line cell An immortal common iliac artery-derived endothelial cell line cell that derives from human. Yue Liu, Yongqun He immortal human embryo-derived fibroblast cell line cell An immortal embryo-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human gonad-derived fibroblast cell line cell An immortal gonad-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human amnion-derived fibroblast cell line cell An immortal amnion-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human thigh-derived fibroblast cell line cell An immortal thigh-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human umbilical vein-derived fibroblast cell line cell An immortal umbilical vein-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal cattle cell line cell An immortal cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cattle vasculature-derived cell line cell An immortal vasculature-derived cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cat spleen-derived cell line cell An immortal spleen-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat fibroblast cell line cell An immortal fibroblast cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat cell line cell An immortal cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat multi-cellular organism-derived cell line cell An immortal multi-cellular organism-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cattle fetal membrane-derived cell line cell An immortal fetal membrane-derived cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cattle spleen-derived cell line cell An immortal spleen-derived cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cattle dento-alveolar joint-derived cell line cell An immortal dento-alveolar joint-derived cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cattle mixed endoderm/mesoderm-derived structure-derived cell line cell An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cat late embryo-derived cell line cell An immortal late embryo-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat muscle spindle-derived cell line cell An immortal muscle spindle-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat thymus-derived cell line cell An immortal thymus-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal human amnion-derived cell line cell An immortal amnion-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal cat skin-derived cell line cell An immortal skin-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal human lymphocyte cell line cell An immortal lymphocyte cell line cell that derives from human. Yue Liu, Yongqun He immortal cat mixed endoderm/mesoderm-derived structure-derived cell line cell An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat tongue-derived cell line cell An immortal tongue-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat pair of lungs-derived cell line cell An immortal pair of lungs-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat fetal membrane-derived cell line cell An immortal fetal membrane-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal cat kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal dog lung-derived fibroblast cell line cell An immortal lung-derived fibroblast cell line cell that derives from dog. Yue Liu, Yongqun He immortal dog abdominal cavity-derived fibroblast cell line cell An immortal abdominal cavity-derived fibroblast cell line cell that derives from dog. Yue Liu, Yongqun He immortal dog thoracic aorta-derived smooth muscle cell line cell An immortal thoracic aorta-derived smooth muscle cell line cell that derives from dog. Yue Liu, Yongqun He immortal cat placenta-derived cell line cell An immortal placenta-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal rat skin-derived cell line cell An immortal skin-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal human fibroblast cell line cell An immortal fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human pericardium-derived fibroblast cell line cell An immortal pericardium-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal cat embryo-derived cell line cell An immortal embryo-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal European rabbit, rabbit embryo-derived cell line cell An immortal embryo-derived cell line cell that derives from European rabbit, rabbit. Yue Liu, Yongqun He cell line cell growth Yongqun He a cell growth where the cell is a cell line cell. immortal cat mononuclear phagocyte cell line cell An immortal mononuclear phagocyte cell line cell that derives from cat. Yue Liu, Yongqun He immortal human foetal structure-derived fibroblast cell line cell An immortal foetal structure-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human external genitalia-derived fibroblast cell line cell An immortal external genitalia-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal rat prostate gland-derived cell line cell An immortal prostate gland-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal human septum of telencephalon-derived cell line cell An immortal septum of telencephalon-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal cabbage moth larva-derived cell line cell An immortal larva-derived cell line cell that derives from cabbage moth. Yue Liu, Yongqun He immortal human mixed endoderm/mesoderm-derived structure-derived cell line cell An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal monkey kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from monkey. Yue Liu, Yongqun He immortal mouse lymphocyte cell line cell An immortal lymphocyte cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human lung-derived cell line cell An immortal lung-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse pair of lungs-derived cell line cell An immortal pair of lungs-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse area X-derived cell line cell An immortal area X-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal Mus musculus x Rattus norvegicus area X-derived cell line cell An immortal area X-derived cell line cell that derives from Mus musculus x Rattus norvegicus. Yue Liu, Yongqun He immortal Chinese hamster somatic nervous system-derived cell line cell An immortal somatic nervous system-derived cell line cell that derives from Chinese hamster. Yue Liu, Yongqun He mouse x rat hybridoma cell line cell Yongqun He a hybridoma cell line cell that is established by fusing cells from a mouse and a rat. immortal mouse fibroblast cell line cell An immortal fibroblast cell line cell that derives from mouse. Yue Liu, Yongqun He immortal common quail cell line cell An immortal cell line cell that derives from common quail. Yue Liu, Yongqun He immortal mouse lymph-derived cell line cell An immortal lymph-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse multi-cellular organism-derived cell line cell An immortal multi-cellular organism-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse embryo-derived cell line cell An immortal embryo-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal turnip moth embryo-derived cell line cell An immortal embryo-derived cell line cell that derives from turnip moth. Yue Liu, Yongqun He immortal cattle thoracic aorta-derived endothelial cell line cell An immortal thoracic aorta-derived endothelial cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cattle lung-derived fibroblast cell line cell An immortal lung-derived fibroblast cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cattle thoracic aorta-derived smooth muscle cell line cell An immortal thoracic aorta-derived smooth muscle cell line cell that derives from cattle. Yue Liu, Yongqun He immortal cattle thigh-derived fibroblast cell line cell An immortal thigh-derived fibroblast cell line cell that derives from cattle. Yue Liu, Yongqun He immortal pig thoracic aorta-derived smooth muscle cell line cell An immortal thoracic aorta-derived smooth muscle cell line cell that derives from pig. Yue Liu, Yongqun He immortal Syrian golden hamster induced T-regulatory cell line cell An immortal induced T-regulatory cell line cell that derives from Syrian golden hamster. Yue Liu, Yongqun He immortal human cell line cell An immortal cell line cell that derives from human. Yue Liu, Yongqun He immortal rat liver-derived cell line cell An immortal liver-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal human colon-derived cell line cell An immortal colon-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human caecum-derived cell line cell An immortal caecum-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse pancreas-derived cell line cell An immortal pancreas-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal pig-tailed macaque lung-derived fibroblast cell line cell An immortal lung-derived fibroblast cell line cell that derives from pig-tailed macaque. Yue Liu, Yongqun He immortal human brain-derived cell line cell An immortal brain-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human trophoblast cell line cell An immortal trophoblast cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse tail-derived cell line cell An immortal tail-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse skin-derived cell line cell An immortal skin-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse collecting duct of renal tubule-derived cell line cell An immortal collecting duct of renal tubule-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse myeloblast cell line cell An immortal myeloblast cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human peripheral neuron cell line cell An immortal peripheral neuron cell line cell that derives from human. Yue Liu, Yongqun He immortal pig-tailed macaque arm-derived fibroblast cell line cell An immortal arm-derived fibroblast cell line cell that derives from pig-tailed macaque. Yue Liu, Yongqun He immortal pig-tailed macaque thoracic aorta-derived smooth muscle cell line cell An immortal thoracic aorta-derived smooth muscle cell line cell that derives from pig-tailed macaque. Yue Liu, Yongqun He immortal mouse mesonephros-derived cell line cell An immortal mesonephros-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal Chinese hamster female gonad-derived cell line cell An immortal female gonad-derived cell line cell that derives from Chinese hamster. Yue Liu, Yongqun He immortal human chorion-derived cell line cell An immortal chorion-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal horse thoracic aorta-derived smooth muscle cell line cell An immortal thoracic aorta-derived smooth muscle cell line cell that derives from horse. Yue Liu, Yongqun He immortal mouse lymphoid follicle-derived cell line cell An immortal lymphoid follicle-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal Syrian golden hamster fetal membrane-derived cell line cell An immortal fetal membrane-derived cell line cell that derives from Syrian golden hamster. Yue Liu, Yongqun He immortal vervet monkey cell line cell An immortal cell line cell that derives from vervet monkey. Yue Liu, Yongqun He immortal vervet monkey kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from vervet monkey. Yue Liu, Yongqun He immortal mouse mast cell line cell An immortal mast cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse epithelial cell line cell An immortal epithelial cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse mixed endoderm/mesoderm-derived structure-derived cell line cell An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse liver-derived cell line cell An immortal liver-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal Drosophila melanogaster embryo-derived cell line cell An immortal embryo-derived cell line cell that derives from Drosophila melanogaster. Yue Liu, Yongqun He immortal human fetal membrane-derived cell line cell An immortal fetal membrane-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal fathead minnow mixed endoderm/mesoderm-derived structure-derived cell line cell An immortal mixed endoderm/mesoderm-derived structure-derived cell line cell that derives from fathead minnow. Yue Liu, Yongqun He immortal human multi-cellular organism-derived cell line cell An immortal multi-cellular organism-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse spleen-derived cell line cell An immortal spleen-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human leg-derived fibroblast cell line cell An immortal leg-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse female gonad-derived cell line cell An immortal female gonad-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse limb/fin-derived cell line cell An immortal limb/fin-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse testis-derived cell line cell An immortal testis-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal rhesus macaque arm-derived fibroblast cell line cell An immortal arm-derived fibroblast cell line cell that derives from rhesus macaque. Yue Liu, Yongqun He immortal human stomach-derived cell line cell An immortal stomach-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human abdominal cavity-derived fibroblast cell line cell An immortal abdominal cavity-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human pancreas-derived cell line cell An immortal pancreas-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal horse thoracic aorta-derived endothelial cell line cell An immortal thoracic aorta-derived endothelial cell line cell that derives from horse. Yue Liu, Yongqun He immortal horse thigh-derived fibroblast cell line cell An immortal thigh-derived fibroblast cell line cell that derives from horse. Yue Liu, Yongqun He immortal horse lung-derived fibroblast cell line cell An immortal lung-derived fibroblast cell line cell that derives from horse. Yue Liu, Yongqun He immortal mouse endothelium-derived cell line cell An immortal endothelium-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human foreskin-derived fibroblast cell line cell An immortal foreskin-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal rhesus macaque thoracic aorta-derived smooth muscle cell line cell An immortal thoracic aorta-derived smooth muscle cell line cell that derives from rhesus macaque. Yue Liu, Yongqun He immortal rhesus macaque lung-derived fibroblast cell line cell An immortal lung-derived fibroblast cell line cell that derives from rhesus macaque. Yue Liu, Yongqun He immortal human achilles tendon-derived fibroblast cell line cell An immortal achilles tendon-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human bone element-derived cell line cell An immortal bone element-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal rat cell line cell An immortal cell line cell that derives from rat. Yue Liu, Yongqun He immortal rat thyroid gland-derived cell line cell An immortal thyroid gland-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal human epithelial cell line cell An immortal epithelial cell line cell that derives from human. Yue Liu, Yongqun He immortal human urinary bladder-derived cell line cell An immortal urinary bladder-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human liver-derived cell line cell An immortal liver-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human acetabular part of hip bone-derived cell line cell An immortal acetabular part of hip bone-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal Ovis cell line cell An immortal cell line cell that derives from Ovis. Yue Liu, Yongqun He immortal gray fox pair of lungs-derived cell line cell An immortal pair of lungs-derived cell line cell that derives from gray fox. Yue Liu, Yongqun He immortal mouse breast-derived cell line cell An immortal breast-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal rhesus macaque cell line cell An immortal cell line cell that derives from rhesus macaque. Yue Liu, Yongqun He immortal rhesus macaque fetal membrane-derived cell line cell An immortal fetal membrane-derived cell line cell that derives from rhesus macaque. Yue Liu, Yongqun He immortal human epithelium-derived cell line cell An immortal epithelium-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal dog kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from dog. Yue Liu, Yongqun He immortal cattle kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from cattle. Yue Liu, Yongqun He immortal human comma-shaped body-derived cell line cell An immortal comma-shaped body-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal sheep kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from sheep. Yue Liu, Yongqun He immortal turkey lymphocyte cell line cell An immortal lymphocyte cell line cell that derives from turkey. Yue Liu, Yongqun He immortal human breast-derived cell line cell An immortal breast-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human spleen-derived cell line cell An immortal spleen-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human supra-orbital vein-derived cell line cell An immortal supra-orbital vein-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse muscle cell line cell An immortal muscle cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human ear-derived fibroblast cell line cell An immortal ear-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human inguinal region-derived fibroblast cell line cell An immortal inguinal region-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal human mesothelium-derived cell line cell An immortal mesothelium-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human uterus-derived cell line cell An immortal uterus-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human endometrium-derived cell line cell An immortal endometrium-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal Syrian golden hamster fibroblast cell line cell An immortal fibroblast cell line cell that derives from Syrian golden hamster. Yue Liu, Yongqun He immortal rat fibroblast cell line cell An immortal fibroblast cell line cell that derives from rat. Yue Liu, Yongqun He immortal Mustelinae pair of lungs-derived cell line cell An immortal pair of lungs-derived cell line cell that derives from Mustelinae. Yue Liu, Yongqun He immortal mouse brain-derived cell line cell An immortal brain-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal chicken cell line cell An immortal cell line cell that derives from chicken. Yue Liu, Yongqun He immortal Mus musculus x Rattus norvegicus cell line cell An immortal cell line cell that derives from Mus musculus x Rattus norvegicus. Yue Liu, Yongqun He immortal pig kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from pig. Yue Liu, Yongqun He immortal cat peripheral neuron cell line cell An immortal peripheral neuron cell line cell that derives from cat. Yue Liu, Yongqun He immortal human uterine cervix-derived cell line cell An immortal uterine cervix-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human heart-derived cell line cell An immortal heart-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal rat pituitary gland-derived cell line cell An immortal pituitary gland-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal Mongolian gerbil pair of lungs-derived cell line cell An immortal pair of lungs-derived cell line cell that derives from Mongolian gerbil. Yue Liu, Yongqun He immortal sheep cell line cell An immortal cell line cell that derives from sheep. Yue Liu, Yongqun He immortal gecko pair of lungs-derived cell line cell An immortal pair of lungs-derived cell line cell that derives from gecko. Yue Liu, Yongqun He immortal mouse urinary bladder-derived cell line cell An immortal urinary bladder-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal walking catfish gill-derived cell line cell An immortal gill-derived cell line cell that derives from walking catfish. Yue Liu, Yongqun He immortal bullfrog tongue-derived cell line cell An immortal tongue-derived cell line cell that derives from bullfrog. Yue Liu, Yongqun He immortal human follicular fluid-derived cell line cell An immortal follicular fluid-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human female gonad-derived cell line cell An immortal female gonad-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human thyroid gland-derived cell line cell An immortal thyroid gland-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal torafugu eye-derived cell line cell An immortal eye-derived cell line cell that derives from torafugu. Yue Liu, Yongqun He immortal mouse spermatocyte cell line cell An immortal spermatocyte cell line cell that derives from mouse. Yue Liu, Yongqun He immortal chicken embryo-derived cell line cell An immortal embryo-derived cell line cell that derives from chicken. Yue Liu, Yongqun He immortal cat brain-derived cell line cell An immortal brain-derived cell line cell that derives from cat. Yue Liu, Yongqun He immortal mouse fetal membrane-derived cell line cell An immortal fetal membrane-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse organism part-derived plasma cell line cell An immortal organism part-derived plasma cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human floating rib-derived cell line cell An immortal floating rib-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal rat urinary bladder-derived cell line cell An immortal urinary bladder-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal mouse mammary gland-derived cell line cell An immortal mammary gland-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human blood cell line cell An immortal blood cell line cell that derives from human. Yue Liu, Yongqun He immortal mouse megakaryocyte-erythroid progenitor cell line cell An immortal megakaryocyte-erythroid progenitor cell line cell that derives from mouse. Yue Liu, Yongqun He immortal Mustelinae septum of telencephalon-derived cell line cell An immortal septum of telencephalon-derived cell line cell that derives from Mustelinae. Yue Liu, Yongqun He immortal guinea pig colon-derived cell line cell An immortal colon-derived cell line cell that derives from guinea pig. Yue Liu, Yongqun He immortal human thorax-derived fibroblast cell line cell An immortal thorax-derived fibroblast cell line cell that derives from human. Yue Liu, Yongqun He immortal bluestriped grunt paired fin-derived cell line cell An immortal paired fin-derived cell line cell that derives from bluestriped grunt. Yue Liu, Yongqun He immortal rat neural nucleus-derived cell line cell An immortal neural nucleus-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal rat Ammon's horn-derived cell line cell An immortal Ammon's horn-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal sheep organism part-derived fibroblast cell line cell An immortal organism part-derived fibroblast cell line cell that derives from sheep. Yue Liu, Yongqun He immortal ferret brain-derived cell line cell An immortal brain-derived cell line cell that derives from ferret. Yue Liu, Yongqun He immortal mouse bone marrow-derived cell line cell An immortal bone marrow-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse septum of telencephalon-derived cell line cell An immortal septum of telencephalon-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal mouse islet of Langerhans-derived cell line cell An immortal islet of Langerhans-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal Miopithecus talapoin kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from Miopithecus talapoin. Yue Liu, Yongqun He immortal budgerigar kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from budgerigar. Yue Liu, Yongqun He immortal mouse thyroid gland-derived cell line cell An immortal thyroid gland-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal human pyramid of medulla oblongata-derived cell line cell An immortal pyramid of medulla oblongata-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal squamate pair of lungs-derived cell line cell An immortal pair of lungs-derived cell line cell that derives from squamate. Yue Liu, Yongqun He immortal mouse aorta-derived cell line cell An immortal aorta-derived cell line cell that derives from mouse. Yongqun He immortal human uterine cervix-derived epithelial cell line cell An immortal uterine cervix-derived epithelial cell line cell that derives from human. Yue Liu, Yongqun He immortal human ileocecal junction-derived cell line cell An immortal ileocecal junction-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human compact bone-derived cell line cell An immortal compact bone-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal rat septum of telencephalon-derived cell line cell An immortal septum of telencephalon-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal human abdominal aorta-derived cell line cell An immortal abdominal aorta-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human bronchus-derived cell line cell An immortal bronchus-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal Syrian golden hamster kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from Syrian golden hamster. Yue Liu, Yongqun He immortal Syrian golden hamster pancreas-derived cell line cell An immortal pancreas-derived cell line cell that derives from Syrian golden hamster. Yue Liu, Yongqun He immortal horse cell line cell An immortal cell line cell that derives from horse. Yue Liu, Yongqun He immortal human organism part-derived keratinocyte cell line cell An immortal organism part-derived keratinocyte cell line cell that derives from human. Yue Liu, Yongqun He immortal human iliac artery-derived cell line cell An immortal iliac artery-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal European rabbit, rabbit synovial membrane of synovial joint-derived cell line cell An immortal synovial membrane of synovial joint-derived cell line cell that derives from European rabbit, rabbit. Yue Liu, Yongqun He immortal Syrian golden hamster septum of telencephalon-derived cell line cell An immortal septum of telencephalon-derived cell line cell that derives from Syrian golden hamster. Yue Liu, Yongqun He immortal Himalayan Tahr female gonad-derived cell line cell An immortal female gonad-derived cell line cell that derives from Himalayan Tahr. Yue Liu, Yongqun He immortal Himalayan Tahr fetal membrane-derived cell line cell An immortal fetal membrane-derived cell line cell that derives from Himalayan Tahr. Yue Liu, Yongqun He immortal human iliac vein-derived cell line cell An immortal iliac vein-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human B cell line cell An immortal B cell line cell that derives from human. Yue Liu, Yongqun He immortal human B-cell line cell immortal human vagina-derived cell line cell An immortal vagina-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human larynx-derived cell line cell An immortal larynx-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human inferior cervical ganglion-derived cell line cell An immortal inferior cervical ganglion-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human esophagus-derived cell line cell An immortal esophagus-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human femoral artery-derived cell line cell An immortal femoral artery-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human prepuce of penis-derived cell line cell An immortal prepuce of penis-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human gingival epithelium-derived cell line cell An immortal gingival epithelium-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human gingiva-derived cell line cell An immortal gingiva-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human muscle cell line cell An immortal muscle cell line cell that derives from human. Yue Liu, Yongqun He immortal human thymus-derived cell line cell An immortal thymus-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal human mouth-derived cell line cell An immortal mouth-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal rat neuron cell line cell An immortal neuron cell line cell that derives from rat. Yue Liu, Yongqun He immortal human limb/fin-derived cell line cell An immortal limb/fin-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal marmoset leukocyte cell line cell An immortal leukocyte cell line cell that derives from marmoset. Yue Liu, Yongqun He immortal Chinese hamster peritoneal macrophage cell line cell An immortal peritoneal macrophage cell line cell that derives from Chinese hamster. Yue Liu, Yongqun He immortal Chinese hamster peritoneum-derived cell line cell An immortal peritoneum-derived cell line cell that derives from Chinese hamster. Yue Liu, Yongqun He immortal human peripheral vein-derived cell line cell An immortal peripheral vein-derived cell line cell that derives from human. Yue Liu, Yongqun He immortal rat brain-derived cell line cell An immortal brain-derived cell line cell that derives from rat. Yue Liu, Yongqun He immortal rat exocrine cell line cell An immortal exocrine cell line cell that derives from rat. Yue Liu, Yongqun He immortal Atlantic salmon kidney-derived cell line cell An immortal kidney-derived cell line cell that derives from Atlantic salmon. Yue Liu, Yongqun He immortal mouse round window-derived cell line cell An immortal round window-derived cell line cell that derives from mouse. Yue Liu, Yongqun He immortal moth female gonad-derived cell line cell An immortal female gonad-derived cell line