Alex Ade
Yuqin Liu
Alexander Diehl
Allen Xiang
Asiyah Yu Lin
Caty Chung
Daniel Cooper
Helen Parkinson
Hiroshi Masuya
Hongjie Pan
James Malone
Jiangan Xie
Jie Zheng
Matthew Brush
Sirarat Sarntivijai
Stefanie Seltmann
Stephan Schurer
Uma Vempati
Xiaolin Yang
Yongqun "Oliver" He (YH)
Yue Liu
2022-03-20
The Cell Line Ontology (CLO) is a community-based ontology of cell lines. The CLO is developed to unify publicly available cell line entry data from multiple sources to a standardized logically defined format based on consensus design patterns.
OWL-DL
An ontology for the domain of cell lines and cell line cells
CLO: Cell Line Ontology
Citation: Sarntivijai S, Lin Y, Xiang Z, Meehan TF, Diehl AD, Vempati UD, Schürer TC, Pang C, Malone J, Parkinson H, Liu Y, Takatsuki T, Saijo K, Masuya H, Nakamura Y, Brush MH, Haendel MA, Zheng J, Stoeckert CJ, Peters B, Mungall CJ, Carey TE, States DJ, Athey BD, He Y. CLO: The Cell Line Ontology. Journal of Biomedical Semantics. 2014, 5:37. doi:10.1186/2041-1480-5-37. PMID: 25852852. PMCID: PMC4387853.
2.1.178
BFO OWL specification label
Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
Really of interest to developers only
BFO OWL specification label
BFO OWL specification label
BFO CLIF specification label
Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
Person:Alan Ruttenberg
Really of interest to developers only
BFO CLIF specification label
BFO CLIF specification label
An annotation property that represents an ID used in the NIH LINCS project.
Oliver He, Jiangan Xie, Jie Zheng
LINCS ID
An annotation property that specifies an STR profile of a cell line cell.
Yongqun He
STR profile
An annotation property that represents a PubMed BioAssay Identifier accession number.
Oliver He
https://pubchem.ncbi.nlm.nih.gov/help.html
PubChem AID
An annotation property that describes the information of a problematic cell line.
Yongqun He
problematic cell line annotation
An annotation property that describes the origin of a cell line.
Oliver He
cell line cell origin
An annotation property that describes the features of a cell line and cell line cell.
Oliver He
cell line cell feature
An annotation property that describes known mutation(s) about a cell.
Oliver He
Known mutation annotation
Cell culture condition
editor preferred label
editor preferred term
The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
editor preferred label
editor preferred label
editor preferred term
editor preferred term
editor preferred term~editor preferred label
example
example of usage
A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
IAO:0000112
uberon
example_of_usage
true
example_of_usage
example of usage
example of usage
in branch
An annotation property indicating which module the terms belong to. This is currently experimental and not implemented yet.
GROUP:OBI
OBI_0000277
in branch
in branch
has curation status
PERSON:Alan Ruttenberg
PERSON:Bill Bug
PERSON:Melanie Courtot
OBI_0000281
has curation status
has curation status
definition
The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
The official definition.
2012-04-05:
Barry Smith
The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
Can you fix to something like:
A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
Alan Ruttenberg
Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
On the specifics of the proposed definition:
We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition
definition
textual definition
editor note
An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
IAO:0000116
uberon
editor_note
true
editor_note
editor note
editor note
term editor
Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor
term editor
alternative term
An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
alternative term
alternative term
definition source
formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
PERSON:Daniel Schober
Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition source
definition source
curator note
An administrative note of use for a curator but of no use for a user
PERSON:Alan Ruttenberg
IAO:0000232
uberon
curator_notes
true
curator_notes
curator note
curator note
curator notes
imported from
For external terms/classes, the ontology from which the term was imported
PERSON:Alan Ruttenberg
PERSON:Melanie Courtot
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
imported from
imported from
expand expression to
expand expression to
expand assertion to
expand assertion to
OBO foundry unique label
elucidation
person:Alan Ruttenberg
Person:Barry Smith
Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms
elucidation
elucidation
has associated axiom(nl)
Person:Alan Ruttenberg
Person:Alan Ruttenberg
An axiom associated with a term expressed using natural language
has associated axiom(nl)
has associated axiom(nl)
has associated axiom(fol)
Person:Alan Ruttenberg
Person:Alan Ruttenberg
An axiom expressed in first order logic using CLIF syntax
has associated axiom(fol)
has associated axiom(fol)
preferred_root
term replaced by
An alternative term used by the IEDB.
IEDB alternative term
temporal interpretation
An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.
temporal interpretation
temporal interpretation
https://oborel.github.io/obo-relations/temporal-semantics/
https://code.google.com/p/obo-relations/wiki/ROAndTime
https://github.com/oborel/obo-relations/wiki/ROAndTime
tooth SubClassOf 'never in taxon' value 'Aves'
S never_in_taxon T iff: S SubClassOf in_taxon only not T.
x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
Chris Mungall
Chris Mungall
?X DisjointWith RO_0002162 some ?Y
Class: <http://www.w3.org/2002/07/owl#Nothing> EquivalentTo: ?X and (RO_0002162 some ?Y)
Class: ?X DisjointWith: RO_0002162 some ?Y
RO:0002161
uberon
never_in_taxon
true
true
never_in_taxon
never in taxon
never_in_taxon
A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B.
non-overlapping with
shares no parts with
Class: <http://www.w3.org/2002/07/owl#Nothing> EquivalentTo: (BFO_0000050 some ?X) and (BFO_0000050 some ?Y)
mutually spatially disjoint with
https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern
S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
RO:0002174
uberon
dubious_for_taxon
true
true
dubious_for_taxon
this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost
dubious_for_taxon
S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S.
https://orcid.org/0000-0002-6601-2165
RO:0002175
applicable for taxon
uberon
present_in_taxon
true
true
present_in_taxon
present in taxon
present in taxon
present_in_taxon
An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL.
logical macro assertion
http://purl.obolibrary.org/obo/ro/docs/shortcut-relations/
A logical macro assertion whose domain is an IRI for a class
The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL
logical macro assertion on a class
A logical macro assertion whose domain is an IRI for a property
logical macro assertion on a property
Used to annotate object properties to describe a logical meta-property or characteristic of the object property.
logical macro assertion on an object property
logical macro assertion on an annotation property
relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y
The general property hierarchy is:
"directly P" SubPropertyOf "P"
Transitive(P)
Where we have an annotation assertion
"directly P" "is direct form of" "P"
If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'
Chris Mungall
is direct form of
A shortcut relationship that holds between two entities based on their identity criteria
logical macro assertion involving identity
A shortcut relationship between two entities x and y1, such that the intent is that the relationship is functional and inverse function, but there is no guarantee that this property holds.
in approximate one to one relationship with
'anterior end of organism' is-opposite-of 'posterior end of organism'
'increase in temperature' is-opposite-of 'decrease in temperature'
x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x).
is opposite of
true if the two properties are disjoint, according to OWL semantics. This should only be used if using a logical axiom introduces a non-simple property violation.
cjm
nominally disjoint with
Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be "+", "-" or "0"
cjm
2018-03-13T23:59:29Z
is directional form of
cjm
2018-03-14T00:03:16Z
is positive form of
cjm
2018-03-14T00:03:24Z
is negative form of
part-of is homeomorphic for independent continuants.
R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C.
cjm
2018-10-21T19:46:34Z
R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C.
is homeomorphic for
An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
UBPROP:0000001
uberon
external_definition
true
external_definition
This annotation property may be replaced with an annotation property from an external ontology such as IAO
external_definition
A textual description of an axiom loss in this ontology compared to an external ontology.
UBPROP:0000002
uberon
axiom_lost_from_external_ontology
true
axiom_lost_from_external_ontology
This annotation property may be replaced with an annotation property from an external ontology such as IAO
axiom_lost_from_external_ontology
Notes on the homology status of this class.
UBPROP:0000003
uberon
homology_notes
true
homology_notes
This annotation property may be replaced with an annotation property from an external ontology such as IAO
homology_notes
UBPROP:0000004
uberon
provenance_notes
true
provenance_notes
provenance_notes
An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info.
UBPROP:0000005
uberon
external_comment
true
external_comment
This annotation property may be replaced with an annotation property from an external ontology such as IAO
external_comment
UBPROP:0000006
uberon
implements_design_pattern
true
implements_design_pattern
implements_design_pattern
Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
UBPROP:0000007
uberon
has_relational_adjective
true
has_relational_adjective
has_relational_adjective
Notes on the how instances of this class vary across species.
UBPROP:0000008
uberon
taxon_notes
true
taxon_notes
taxon_notes
Notes on the evolved function of instances of this class.
This annotation property may be replaced with an annotation property from an external ontology such as IAO
UBPROP:0000009
uberon
function_notes
true
function_notes
function_notes
Notes on the structure, composition or histology of instances of this class.
This annotation property may be replaced with an annotation property from an external ontology such as IAO
UBPROP:0000010
uberon
structure_notes
true
structure_notes
structure_notes
Notes on the ontogenic development of instances of this class.
This annotation property may be replaced with an annotation property from an external ontology such as IAO
UBPROP:0000011
uberon
development_notes
true
development_notes
development_notes
Notes on how similar or equivalent classes are represented in other ontologies.
This annotation property may be replaced with an annotation property from an external ontology such as IAO
UBPROP:0000012
uberon
external_ontology_notes
true
external_ontology_notes
external_ontology_notes
Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy.
This annotation property may be replaced with an annotation property from an external ontology such as IAO
UBPROP:0000013
uberon
terminology_notes
true
terminology_notes
terminology_notes
FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term
UBPROP:0000202
uberon
fma_set_term
true
fma_set_term
fma_set_term
Examples of a Contributor include a person, an
organisation, or a service. Typically, the name of a
Contributor should be used to indicate the entity.
http://purl.org/dc/elements/1.1/contributor
uberon
dc-contributor
true
dc-contributor
An entity responsible for making contributions to the
content of the resource.
Contributor
Contributor
contributor
Examples of a Creator include a person, an organisation,
or a service. Typically, the name of a Creator should
be used to indicate the entity.
http://purl.org/dc/elements/1.1/creator
uberon
dc-creator
true
dc-creator
An entity primarily responsible for making the content
of the resource.
Creator
Creator
creator
Typically, Date will be associated with the creation or
availability of the resource. Recommended best practice
for encoding the date value is defined in a profile of
ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format.
A date associated with an event in the life cycle of the
resource.
Date
Date
Description may include but is not limited to: an abstract,
table of contents, reference to a graphical representation
of content or a free-text account of the content.
http://purl.org/dc/elements/1.1/description
uberon
dc-description
true
dc-description
An account of the content of the resource.
Description
Description
description
Typically, Format may include the media-type or dimensions of
the resource. Format may be used to determine the software,
hardware or other equipment needed to display or operate the
resource. Examples of dimensions include size and duration.
Recommended best practice is to select a value from a
controlled vocabulary (for example, the list of Internet Media
Types [MIME] defining computer media formats).
The physical or digital manifestation of the resource.
Format
Format
The present resource may be derived from the Source resource
in whole or in part. Recommended best practice is to reference
the resource by means of a string or number conforming to a
formal identification system.
A reference to a resource from which the present resource
is derived.
Source
Source
Typically, a Subject will be expressed as keywords,
key phrases or classification codes that describe a topic
of the resource. Recommended best practice is to select
a value from a controlled vocabulary or formal
classification scheme.
The topic of the content of the resource.
Subject and Keywords
Subject and Keywords
Typically, a Title will be a name by which the resource is
formally known.
http://purl.org/dc/elements/1.1/title
uberon
dc-title
true
dc-title
A name given to the resource.
Title
Title
title
uberon
dc-contributor
true
dc-contributor
contributor
http://purl.org/dc/terms/license
uberon
dcterms-license
true
dcterms-license
license
consider
Author of the class.
created_by
Date class was created.
creation_date
ID of merged class.
has_alternative_id
has_broad_synonym
Reference database or publication source.
database_cross_reference
Exact synonym.
has exact synonym
has_exact_synonym
has_narrow_synonym
Name space of the ontology.
disease_ontology
has_obo_namespace
Has related synonym.
has_related_synonym
An identifier for an individual entity.
An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity.
id
In subset.
in_subset
shorthand
Comment.
comment
Is defined by.
rdfs:isDefinedBy
A human readable name for this class.
label
label
http://www.w3.org/2000/01/rdf-schema#seeAlso
seeAlso
uberon
seeAlso
true
seeAlso
see also
OWL deprecated.
owl:deprecated
A skos concept mapping used to link two concepts, indicating a high degree of confidence that the concepts can be used interchangeably.
has exact match
http://xmlns.com/foaf/0.1/depicted_by
uberon
depicted_by
true
depicted_by
depicted by
is part of
my brain is part of my body (continuant parthood, two material entities)
my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
this day is part of this year (occurrent parthood)
a core relation that holds between a part and its whole
Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)
A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
part_of
BFO:0000050
external
quality
uberon
part_of
part_of
part of
part of
part_of
http://www.obofoundry.org/ro/#OBO_REL:part_of
has part
my body has part my brain (continuant parthood, two material entities)
my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
this year has part this day (occurrent parthood)
a core relation that holds between a whole and its part
Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)
A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
has_part
BFO:0000051
external
quality
uberon
has_part
has_part
has part
has part
has_part
realized in
this disease is realized in this disease course
this fragility is realized in this shattering
this investigator role is realized in this investigation
is realized by
realized_in
[copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process
realized in
realizes
this disease course realizes this disease
this investigation realizes this investigator role
this shattering realizes this fragility
to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process
realizes
participates_in
preceded by
X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X).
x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
is preceded by
preceded_by
http://www.obofoundry.org/ro/#OBO_REL:preceded_by
BFO:0000062
is preceded by
takes place after
external
uberon
preceded_by
preceded_by
preceded by
preceded by
preceded_by
precedes
x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
BFO:0000063
external
uberon
precedes
precedes
precedes
precedes
occurs in
b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
occurs_in
unfolds in
unfolds_in
BFO:0000066
external
occurs_in
occurs_in
Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
occurs in
occurs in
site of
[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
BFO:0000067
uberon
contains_process
contains_process
Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant
contains process
contains process
located_in
http://www.ebi.ac.uk/efo/has_quality
has_quality
x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer.
cjm
2009-07-31T02:15:46Z
BSPO:0000096
uberon
anterior_to
anterior_to
anterior_to
x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal).
BSPO:0000097
uberon
distal_to
distal_to
distal_to
x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
BSPO:0000098
uberon
dorsal_to
dorsal_to
dorsal_to
x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail.
BSPO:0000099
caudal_to
uberon
posterior_to
posterior_to
posterior_to
x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
BSPO:0000102
uberon
ventral_to
ventral_to
ventral_to
BSPO:0000107
uberon
deep_to
deep_to
deep_to
BSPO:0000108
uberon
superficial_to
superficial_to
superficial_to
X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion.
BSPO:0000120
uberon
in_left_side_of
in_left_side_of
in_left_side_of
https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern
X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion.
BSPO:0000121
uberon
in_right_side_of
in_right_side_of
in_right_side_of
https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern
X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion.
BSPO:0000122
uberon
in_posterior_side_of
in_posterior_side_of
in_posterior_side_of
X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion.
BSPO:0000123
uberon
in_anterior_side_of
in_anterior_side_of
in_anterior_side_of
X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion.
BSPO:0000124
uberon
in_proximal_side_of
in_proximal_side_of
in_proximal_side_of
X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion.
BSPO:0000125
uberon
in_distal_side_of
in_distal_side_of
in_distal_side_of
X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure.
BSPO:0000126
uberon
in_lateral_side_of
in_lateral_side_of
in_lateral_side_of
https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern
X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y.
BSPO:0001106
uberon
proximalmost_part_of
proximalmost_part_of
proximalmost_part_of
This relation holds when both the deep_to and ajdacent_to relationship similarly hold.
BSPO:0001107
uberon
immediately_deep_to
immediately_deep_to
immediately_deep_to
X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y.
BSPO:0001108
uberon
distalmost_part_of
distalmost_part_of
distalmost_part_of
a 'derives from' object property between an entity (in CLO case, cell line) and a disease in a patient where the entity is derived from some cell in the patient who has the disease.
This is a short cut relation that represents:
'derived from' some (cell and ('part of' some 'organism' and ('has disease' some disease)))
Yongqun He
In most cases, the patient in the relation is used to refer human patient. However, an animal patient (or veterinary patient) can also be referred.
derives from patient having disease
a disease disposition has been realized by a bearer.
Jie Zheng, Yongqun He, Yu Lin, Allen Xiang
This is a shortcut relation. It is equivalent to:
participates_in some 'disease couse' and realizes some disease
has disease
an object property that specifies a cell line repository for a specifc cell line.
SS, YH, UV, SS
is in cell line repository
an object property that represents a relation between a cell line cell and a disease.
Asiyah Yu Lin, Yongqun He
This object property is largely equivalent to the previous term 'is model for' (http://www.ebi.ac.uk/cellline#is_model_for).
is disease model for
HeLa ICRP cell is transfected to express a Initiator caspase reporter protein (IC-RP)
an object property that represents a relation between a cell line cell and a protein where the cell line cell is genetically transfected to stably express a foreign protein in the cell line cell.
Oliver He, Asiyah Yu Lin
transfected to express
a 'cell line cell derives from' object property between an entity (e.g., cell line cell in CLO) and an organism where the cell line cell is derived from some cell from the organism.
In CLO, this is a short cut relation that represents:
'derived from' some (cell and ('part of' some organism))
derived from organism
a 'derives from' object property between an entity (i.e., cell line cell in CLO) and an anatomic part from an organism where the cell line cell is derived from some cell in the anatomic part (e.g., tissue or organ). The anatomic part is typically defined by UBERON in CLO.
in CLO, this is a short cut relation that represents:
'derived from' some (cell and ('part of' some 'anatomic part'))
derived from anatomic part
derived from cell
derived from cell line
a 'derived from' object property that specifies the domain of the property is a cell line cell.
Oliver He
cell line cell derived from
a 'cell line cell derives from' object property between a cell line cell and an anatomic part from an organism where the cell line cell is derived from some cell in the tissue. The anatomic part is typically defined by UBERON in CLO.
This is a short cut relation that represents:
'derived from' some (cell and ('part of' some 'anatomic part'))
Oliver He
cell line cell derived from anatomical part
a 'cell line cell derives from' object property between a cell line cell and an organism where the cell line cell is derived from some cell from the organism.
This is a short cut relation that represents:
'derived from' some (cell and ('part of' some organism))
Oliver He
cell line cell derived from organism
induced by cell culture reagent
BIHi005-A-4 stem cell line cell is derived from BIHi005-A cell by knocking out the gene SORT1 from the BIHi005-A cell.
A 'derives from' object property that represents the relation between a cell line cell and a gene where the gene is not present in the cell line cell from a knockout process.
Stefanie Seltmann, Oliver He
derived from cell with knockout gene
Stem cell line cell BIONi010-C-6 is derived from BIONi010-C where gene APOE has been modified from an isogenic modification.
A 'derives from' object property that represents the relation between a cell line cell and a gene where the gene is modified in the cell line cell via an isogenic modification process. An isogenic cell line is a cell line that has been engineered from a parental line through the introduction of a targeted gene mutation.
Stefanie Seltmann, Oliver He
derived from cell with isogenic modification of gene
derived from cell with knockin gene
derived from cell with transgenic modification
GOREL:0002004
external
results_in_fission_of
results_in_fission_of
results_in_fission_of
is about
This document is about information artifacts and their representations
is_about is a (currently) primitive relation that relates an information artifact to an entity.
7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive.
We will try to build it back up by elaborating the various subproperties that are more precisely defined.
Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
person:Alan Ruttenberg
Smith, Ceusters, Ruttenberg, 2000 years of philosophy
is about
An information artifact IA mentions an entity E exactly when it has a component/part that denotes E
7/6/2009 Alan Ruttenberg. P4 RC1 munges our GCI so remove it for now: mentions some entity equivalentTo has_part some ('generically denotes' some entity)
7/6/2009 Alan Ruttenberg: Add this relation following conversation with Jonathan Rees that N&S GCI for is_about was too strong. Really it was simply sufficient. To effect this change we introduce this relation, which is subproperty of is_about, and have previous GCI use this relation "mentions" in it's (logical) definition
PERSON: Jonathan Rees
Person: Alan Ruttenberg
mentions
has_specified_input
see is_input_of example_of_usage
A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works.
PERSON: Alan Ruttenberg
PERSON: Bjoern Peters
PERSON: Larry Hunter
PERSON: Melanie Coutot
has_specified_input
is_specified_input_of
some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay
A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
Alan Ruttenberg
PERSON:Bjoern Peters
is_specified_input_of
has_specified_output
A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
PERSON: Alan Ruttenberg
PERSON: Bjoern Peters
PERSON: Larry Hunter
PERSON: Melanie Courtot
has_specified_output
is_manufactured_by
http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities)
c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this.
Alan Ruttenberg
Liju Fan
has_make
has_manufacturer
is_manufactured_by
is_specified_output_of
A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
Alan Ruttenberg
PERSON:Bjoern Peters
is_specified_output_of
achieves_planned_objective
A cell sorting process achieves the objective specification 'material separation objective'
This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process.
BP, AR, PPPB branch
PPPB branch derived
modified according to email thread from 1/23/09 in accordince with DT and PPPB branch
achieves_planned_objective
has grain
the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car.
Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form
PERSON: Alan Ruttenberg
PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349
has grain
objective_achieved_by
This relation obtains between a a objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process.
OBI
OBI
objective_achieved_by
inheres in
this fragility inheres in this vase
this fragility is a characteristic of this vase
this red color inheres in this apple
this red color is a characteristic of this apple
a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence
A dependent inheres in its bearer at all times for which the dependent exists.
inheres_in
Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
characteristic of
inheres in
bearer of
this apple is bearer of this red color
this vase is bearer of this fragility
Inverse of characteristic_of
a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
bearer_of
is bearer of
RO:0000053
external
uberon
bearer_of
bearer_of
bearer of
bearer of
has characteristic
participates in
this blood clot participates in this blood coagulation
this input material (or this output material) participates in this process
this investigator participates in this investigation
a relation between a continuant and a process, in which the continuant is somehow involved in the process
participates_in
RO:0000056
external
uberon
participates_in
participates_in
participates in
participates in
participates_in
has participant
this blood coagulation has participant this blood clot
this investigation has participant this investigator
this process has participant this input material (or this output material)
a relation between a process and a continuant, in which the continuant is somehow involved in the process
Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
has_participant
http://www.obofoundry.org/ro/#OBO_REL:has_participant
RO:0000057
external
has_participant
has_participant
has participant
has participant
concretizes
A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant).
An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process).
A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant.
concretizes
has function
this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)
a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
has_function
has function
this apple has quality this red color
a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
has_quality
RO:0000086
uberon
has_quality
has_quality
has quality
has quality
has role
this person has role this investigator role (more colloquially: this person has this role of investigator)
a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
has_role
has role
has role
derives from
this cell derives from this parent cell (cell division)
this nucleus derives from this parent nucleus (nuclear division)
a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'.
derives_from
derives from
derives_from
derives into
this parent cell derives into this cell (cell division)
this parent nucleus derives into this nucleus (nuclear division)
a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'.
derives_into
derives into
is location of
my head is the location of my brain
this cage is the location of this rat
a relation between two independent continuants, the location and the target, in which the target is entirely within the location
Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
location_of
RO:0001015
uberon
location_of
location_of
location of
location_of
located in
my brain is located in my head
this rat is located in this cage
a relation between two independent continuants, the target and the location, in which the target is entirely within the location
Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
located_in
http://www.obofoundry.org/ro/#OBO_REL:located_in
RO:0001025
uberon
located_in
located_in
located in
located_in
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts.
Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape.
David Osumi-Sutherland
has boundary
has_2D_boundary
RO:0002002
uberon
has_boundary
has_boundary
has 2D boundary
has boundary
David Osumi-Sutherland
http://www.ncbi.nlm.nih.gov/pubmed/22402613
RO:0002005
nerve supply
uberon
innervated_by
innervated_by
http://code.google.com/p/obo-relations/issues/detail?id=6
innervated_by
innervated_by
X outer_layer_of Y iff:
. X :continuant that bearer_of some PATO:laminar
. X part_of Y
. exists Z :surface
. X has_boundary Z
. Z boundary_of Y
has_boundary: http://purl.obolibrary.org/obo/RO_0002002
boundary_of: http://purl.obolibrary.org/obo/RO_0002000
David Osumi-Sutherland
RO:0002007
external
uberon
bounding_layer_of
bounding_layer_of
A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.
A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.
bounding layer of
bounding layer of
dos
2017-05-24T09:44:33Z
A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
has component activity
w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
dos
2017-05-24T09:49:21Z
has component process
A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.
dos
2017-07-20T17:19:37Z
occurs across
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
dos
2017-09-22T14:14:36Z
This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
has effector activity
David Osumi-Sutherland
<=
Primitive instance level timing relation between events
before or simultaneous with
Relation between occurrents, shares start and end boundaries.
David Osumi-Sutherland
RO:0002082
coincides_with
is_equal_to
uberon
simultaneous_with
simultaneous_with
t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
simultaneous with
simultaneous_with
David Osumi-Sutherland
X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)
ends after
X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y).
David Osumi-Sutherland
starts_at_end_of
A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
RO:0002087
directly preceded by
is directly preceded by
is immediately preceded by
starts_at_end_of
external
uberon
immediately_preceded_by
immediately_preceded_by
X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
immediately preceded by
immediately_preceded_by
David Osumi-Sutherland
ends_at_start_of
meets
RO:0002090
external
immediately_precedes
immediately_precedes
X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)
immediately precedes
immediately_precedes
David Osumi-Sutherland
io
X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))
starts during
David Osumi-Sutherland
d
during
X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))
happens during
David Osumi-Sutherland
o
overlaps
X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).
ends during
Relation between a neuron and an anatomical structure that its soma is part of.
David Osumi-Sutherland
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
has soma location
Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]
Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
Alexander Diehl
Chris Mungall
Lindsay Cowell
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0005886> and <http://purl.obolibrary.org/obo/BFO_0000051> some ?Y)
has plasma membrane part
x overlaps y if and only if there exists some z such that x has part z and z part of y
BFO_0000051 some (BFO_0000050 some ?Y)
http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
RO:0002131
external
uberon
overlaps
overlaps
overlaps
overlaps
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
David Osumi-Sutherland
<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
RO:0002134
uberon
innervates
innervates
http://code.google.com/p/obo-relations/issues/detail?id=6
innervates
innervates
X continuous_with Y if and only if X and Y share a fiat boundary.
David Osumi-Sutherland
connected to
The label for this relation was previously connected to. I relabeled this to "continuous with". The standard notion of connectedness does not imply shared boundaries - e.g. Glasgow connected_to Edinburgh via M8; my patella connected_to my femur (via patellar-femoral joint)
RO:0002150
uberon
continuous_with
continuous_with
continuous with
continuous_with
FMA:85972
two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a.
Consider obsoleting and merging with child relation, 'in homology relationship with'
RO:0002158
uberon
homologous_to
homologous_to
VBO calls this homologous_to
homologous_to
shares ancestor with
lactation SubClassOf 'only in taxon' some 'Mammalia'
S only_in_taxon T iff: S SubClassOf in_taxon only T.
x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z.
The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g.
'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria
Chris Mungall
RO:0002160
uberon
only_in_taxon
only_in_taxon
only in taxon
only_in_taxon
x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.
Chris Mungall
Jennifer Deegan
RO:0002162
uberon
in_taxon
in_taxon
Connects a biological entity to its taxon of origin.
in taxon
A is spatially_disjoint_from B if and only if they have no parts in common
There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom.
Chris Mungall
Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy
BFO_0000051 exactly 0 (BFO_0000050 some ?Y)
spatially disjoint from
https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern
a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones).
Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.
a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b
RO:0002170
uberon
connected_to
connected_to
Connection does not imply overlaps.
connected to
connected to
https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern
https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern
The M8 connects Glasgow and Edinburgh
a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones).
Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.
c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system.
this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)
RO:0002176
uberon
connects
connects
connects
connects
https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern
https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern
a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.
attached to part of (anatomical structure to anatomical structure)
RO:0002177
uberon
attaches_to_part_of
attaches_to_part_of
attached to part of
attaches_to_part_of
Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy.
relation between an artery and the structure is supplies with blood.
Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure
RO:0002178
arterial supply of
uberon
supplies
supplies
source: FMA
supplies
supplies
Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure.
Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure
RO:0002179
drains blood from
drains from
uberon
drains
drains
source: Wikipedia
drains
drains
w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity.
For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit.
RO:0002180
external
uberon
has_component
has_component
has component
has component
x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
Chris Mungall
David Osumi-Sutherland
Melissa Haendel
Terry Meehan
RO:0002202
uberon
develops_from
develops_from
This is the transitive form of the develops from relation
develops from
develops_from
inverse of develops from
Chris Mungall
David Osumi-Sutherland
Terry Meehan
RO:0002203
uberon
develops_into
develops_into
develops into
develops_into
'neural crest cell' SubClassOf expresses some 'Wnt1 gene'
x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process
Chris Mungall
expressed in
Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y.
Chris Mungall
David Osumi-Sutherland
has developmental precursor
FBbt
RO:0002207
uberon
directly_develops_from
directly_develops_from
TODO - add child relations from DOS
directly develops from
directly_develops_from
inverse of directly develops from
developmental precursor of
directly develops into
process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit
Chris Mungall
David Hill
Tanya Berardini
GO
Regulation precludes parthood; the regulatory process may not be within the regulated process.
regulates (processual)
false
RO:0002211
external
regulates
regulates
regulates
regulates
Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
Chris Mungall
negatively regulates (process to process)
RO:0002212
external
negatively_regulates
negatively_regulates
negatively regulates
negatively regulates
Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
Chris Mungall
positively regulates (process to process)
RO:0002213
external
positively_regulates
positively_regulates
positively regulates
positively regulates
'human p53 protein' SubClassOf some ('has prototype' some ('participates in' some 'DNA repair'))
heart SubClassOf 'has prototype' some ('participates in' some 'blood circulation')
x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a "canonical" heart, which participates in blood circulation.
Experimental. In future there may be a formalization in which this relation is treated as a shortcut to some modal logic axiom. We may decide to obsolete this and adopt a more specific evolutionary relationship (e.g. evolved from)
TODO: add homeomorphy axiom
This property can be used to make weaker forms of certain relations by chaining an additional property. For example, we may say: retina SubClassOf has_prototype some 'detection of light'. i.e. every retina is related to a prototypical retina instance which is detecting some light. Note that this is very similar to 'capable of', but this relation affords a wider flexibility. E.g. we can make a relation between continuants.
Chris Mungall
has prototype
mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)
osteoclast SubClassOf 'capable of' some 'bone resorption'
A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
Chris Mungall
has function realized in
For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".
RO:0002215
external
uberon
capable_of
capable_of
capable of
capable of
c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
Chris Mungall
has function in
RO:0002216
external
uberon
capable_of_part_of
capable_of_part_of
capable of part of
capable of part of
x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y.
Chris Mungall
RO:0002219
uberon
surrounded_by
surrounded_by
surrounded by
surrounded_by
A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts.
The epidermis layer of a vertebrate is adjacent to the dermis.
The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies.
The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used.
x adjacent to y if and only if x and y share a boundary.
x adjacent_to y iff: x and y share a boundary.
This relation acts as a join point with BSPO
Chris Mungall
RO:0002220
external
uberon
adjacent_to
adjacent_to
adjacent to
adjacent to
adjacent_to
inverse of surrounded by
inverse of surrounded_by.
Chris Mungall
RO:0002221
uberon
surrounds
surrounds
surrounds
surrounds
Chris Mungall
Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1
A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.
temporally related to
Relation between occurrents, shares a start boundary with.
inverse of starts with
Chris Mungall
Allen
RO:0002223
uberon
starts
starts
starts
starts
Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor
x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
Chris Mungall
started by
RO:0002224
external
uberon
starts_with
starts_with
starts with
starts with
x develops from part of y if and only if there exists some z such that x develops from z and z is part of y
Chris Mungall
RO:0002225
uberon
develops_from_part_of
develops_from_part_of
develops from part of
develops_from_part_of
Relation between occurrents, shares an end boundary with.
inverse of ends with
Chris Mungall
RO:0002229
finishes
uberon
ends
ends
ends
ends
x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
Chris Mungall
finished by
RO:0002230
external
uberon
ends_with
ends_with
ends with
ends with
x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y
Chris Mungall
starts with process that occurs in
RO:0002231
external
has_start_location
has_start_location
has start location
has start location
x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y
Chris Mungall
ends with process that occurs in
RO:0002232
external
has_end_location
has_end_location
has end location
has end location
p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
Chris Mungall
consumes
RO:0002233
external
has_input
has_input
has input
has input
p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.
Chris Mungall
produces
RO:0002234
external
has_output
has_output
has output
has output
Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]
x has developmental contribution from y iff x has some part z such that z develops from y
Chris Mungall
RO:0002254
uberon
has_developmental_contribution_from
has_developmental_contribution_from
has developmental contribution from
has developmental contribution from
inverse of has developmental contribution from
Chris Mungall
RO:0002255
uberon
developmentally_contributes_to
developmentally_contributes_to
developmentally contributes to
developmentally_contributes_to
t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.
t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T
Chris Mungall
David Osumi-Sutherland
Melissa Haendel
induced by
Developmental Biology, Gilbert, 8th edition, figure 6.5(F)
GO:0001759
We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]
RO:0002256
uberon
developmentally_induced_by
developmentally_induced_by
sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)
developmentally induced by
developmentally_induced_by
Inverse of developmentally induced by
Chris Mungall
developmentally induces
Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
false
Chris Mungall
In general you should not use this relation to make assertions - use one of the more specific relations below this one
RO:0002258
uberon
developmentally_preceded_by
developmentally_preceded_by
This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from
developmentally preceded by
developmentally preceded by
x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else
This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage
Chris Mungall
replaces
RO:0002285
uberon
developmentally_replaces
developmentally_replaces
developmentally replaces
developmentally_replaces
Inverse of developmentally preceded by
Chris Mungall
developmentally succeeded by
Inverse of 'expressed in'
Chris Mungall
expresses
p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint.
Chris Mungall
RO:0002295
external
results_in_developmental_progression_of
results_in_developmental_progression_of
results in developmental progression of
results in developmental progression of
every flower development (GO:0009908) results in development of some flower (PO:0009046)
p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state.
Chris Mungall
http://www.geneontology.org/GO.doc.development.shtml
RO:0002296
external
results_in_development_of
results_in_development_of
results in development of
results in development of
an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists.
every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062)
Chris Mungall
GOC:mtg_berkeley_2013
RO:0002297
external
results_in_formation_of
results_in_formation_of
results in formation of
results in formation of
an annotation of gene X to cell morphogenesis with results_in_morphogenesis_of CL:0000540 (neuron) means that at the end of the process an input neuron has attained its shape.
tongue morphogenesis (GO:0043587) results in morphogenesis of tongue (UBERON:0001723)
The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.
Chris Mungall
GOC:mtg_berkeley_2013
RO:0002298
external
results_in_morphogenesis_of
results_in_morphogenesis_of
results in morphogenesis of
results in morphogenesis of
cjm
RO:0002304
external
causally_upstream_of,_positive_effect
causally_upstream_of,_positive_effect
holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
causally upstream of, positive effect
cjm
RO:0002305
external
causally_upstream_of,_negative_effect
causally_upstream_of,_negative_effect
holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y
causally upstream of, negative effect
Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment) and the outcome of this process is to regulate the localization of c.
Chris Mungall
regulates localization of
RO:0002313
external
transports_or_maintains_localization_of
transports_or_maintains_localization_of
transports or maintains localization of
transports or maintains localization of
q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.
Because part_of is transitive, inheres in is a sub-relation of characteristic of part of
Chris Mungall
inheres in part of
characteristic of part of
an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast.
The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
Chris Mungall
GOC:mtg_berkeley_2013
RO:0002315
external
results_in_acquisition_of_features_of
results_in_acquisition_of_features_of
results in acquisition of features of
results in acquisition of features of
A relationship that holds via some environmental process
Chris Mungall
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution.
evolutionarily related to
A mereological relationship or a topological relationship
Chris Mungall
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
mereotopologically related to
A relationship that holds between entities participating in some developmental process (GO:0032502)
Chris Mungall
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development
developmentally related to
A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
Chris Mungall
This is a grouping relation that collects relations used for the purpose of connecting structure and function
RO:0002328
uberon
functionally_related_to
functionally_related_to
functionally related to
functionally related to
holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts.
Chris Mungall
Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving the genome of an organism
genomically related to
inverse of regulates
Chris Mungall
regulated by (processual)
RO:0002334
external
regulated_by
regulated_by
regulated by
regulated by
inverse of negatively regulates
Chris Mungall
RO:0002335
external
negatively_regulated_by
negatively_regulated_by
negatively regulated by
negatively regulated by
inverse of positively regulates
Chris Mungall
RO:0002336
external
positively_regulated_by
positively_regulated_by
positively regulated by
positively regulated by
A relationship that holds via some process of localization
Chris Mungall
Do not use this relation directly. It is a grouping relation.
related via localization to
This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination.
Chris Mungall
RO:0002338
external
has_target_start_location
has_target_start_location
has target start location
has target start location
This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l.
Chris Mungall
RO:0002339
external
has_target_end_location
has_target_end_location
has target end location
has target end location
Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l
Chris Mungall
RO:0002341
external
results_in_transport_along
results_in_transport_along
results in transport along
results in transport along
Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m.
Chris Mungall
RO:0002342
external
results_in_transport_across
results_in_transport_across
results in transport across
results in transport across
'mitochondrial transport' results_in_transport_to_from_or_in some mitochondrion (GO:0005739)
Chris Mungall
RO:0002344
external
results_in_transport_to_from_or_in
results_in_transport_to_from_or_in
results in transport to from or in
results in transport to from or in
has member is a mereological relation between a collection and an item.
SIO
RO:0002351
uberon
has_member
has_member
has member
has member
inverse of has input
Chris Mungall
RO:0002352
uberon
input_of
input_of
input of
input of
inverse of has output
Chris Mungall
RO:0002353
external
uberon
output_of
output_of
output of
output of
Chris Mungall
formed as result of
a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a
Chris Mungall
attached to (anatomical structure to anatomical structure)
RO:0002371
uberon
attaches_to
attaches_to
attached to
attaches_to
A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network.
Chris Mungall
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving branching relationships
This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (plant branches and roots, leaf veins, animal veins, arteries, nerves)
in branching relationship with
https://github.com/obophenotype/uberon/issues/170
In the tree T depicted in https://oborel.github.io/obo-relations/branching_part_of.png, B1 is a (direct) branching part of T. B1-1, B1-2, and B1-3 are also branching parts of T, but these are considered indirect branching parts as they do not directly connect to the main stem S
x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y
we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve
Chris Mungall
RO:0002380
uberon
branching_part_of
branching_part_of
branching part of
branching_part_of
FMA:85994
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
Chris Mungall
has developmental potential involving
x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y.
Chris Mungall
RO:0002385
uberon
has_potential_to_developmentally_contribute_to
has_potential_to_developmentally_contribute_to
has potential to developmentally contribute to
has potential to developmentally contribute to
x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y
Chris Mungall
has potential to developmentally induce
x has the potential to develop into y iff x develops into y or if x is capable of developing into y
x has the potential to develop into y iff x develops into y or if x is capable of developing into y.
Chris Mungall
RO:0002387
uberon
has_potential_to_develop_into
has_potential_to_develop_into
has potential to develop into
has potential to develop into
x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y.
Chris Mungall
RO:0002388
uberon
has_potential_to_directly_develop_into
has_potential_to_directly_develop_into
has potential to directly develop into
has potential to directly develop into
This relation groups causal relations between material entities and causal relations between processes
This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.
To define causal relations in an activity-flow type network, we make use of 3 primitives:
* Temporal: how do the intervals of the two occurrents relate?
* Is the causal relation regulatory?
* Is the influence positive or negative
The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.
For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.
For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.
Each of these 3 primitives can be composed to yield a cross-product of different relation types.
Chris Mungall
Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
causally related to
p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain
Chris Mungall
RO:0002411
external
causally_upstream_of
causally_upstream_of
causally upstream of
causally upstream of
p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.
Chris Mungall
RO:0002412
external
immediately_causally_upstream_of
immediately_causally_upstream_of
immediately causally upstream of
immediately causally upstream of
p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2
Chris Mungall
influences (processual)
RO:0002418
external
affects
causally_upstream_of_or_within
causally_upstream_of_or_within
causally upstream of or within
inverse of causally upstream of or within
Chris Mungall
RO:0002427
external
causally_downstream_of_or_within
causally_downstream_of_or_within
causally downstream of or within
p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm.
Chris Mungall
RO:0002433
uberon
contributes_to_morphology_of
contributes_to_morphology_of
contributes to morphology of
'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'
x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
x composed_primarily_of y iff: more than half of the mass of x is made from parts of y.
Chris Mungall
RO:0002473
uberon
composed_primarily_of
composed_primarily_of
composed primarily of
p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.
Chris Mungall
has part that occurs in
Chris Mungall
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage.
relation between physical entity and a process or stage
Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.
x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y).
Chris Mungall
RO:0002488
begins_to_exist_during
uberon
existence_starts_during
existence_starts_during
existence starts during
Relation between continuant and occurrent, such that c comes into existence at the start of p.
x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y).
Chris Mungall
RO:0002489
uberon
existence_starts_with
existence_starts_with
existence starts with
x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))
Chris Mungall
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
existence overlaps
x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)
Chris Mungall
RO:0002491
exists during
uberon
existence_starts_and_ends_during
existence_starts_and_ends_during
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
existence starts and ends during
Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.
x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y).
Chris Mungall
RO:0002492
ceases_to_exist_during
uberon
existence_ends_during
existence_ends_during
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
existence ends during
Relation between continuant and occurrent, such that c ceases to exist at the end of p.
x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y).
Chris Mungall
RO:0002493
uberon
existence_ends_with
existence_ends_with
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
existence ends with
x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships
Chris Mungall
RO:0002494
transforms from
uberon
transformation_of
transformation_of
transformation of
x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t
Chris Mungall
RO:0002495
direct_transformation_of
immediately transforms from
uberon
immediate_transformation_of
immediate_transformation_of
immediate transformation of
x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).
Chris Mungall
RO:0002496
uberon
existence_starts_during_or_after
existence_starts_during_or_after
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
existence starts during or after
x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.
Chris Mungall
RO:0002497
uberon
existence_ends_during_or_before
existence_ends_during_or_before
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
existence ends during or before
A relationship between a material entity and a process where the material entity has some causal role that influences the process
causal agent in process
p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
Chris Mungall
Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
causal relation between processes
Chris Mungall
depends on
Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'
A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision.
Chris Mungall
has supporting framework
The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell).
RO:0002551
uberon
has sekeletal support
has supporting framework
has_skeleton
has_skeleton
has skeleton
Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c
Chris Mungall
RO:0002565
external
results_in_movement_of
results_in_movement_of
results in movement of
A relation that holds between elements of a musculoskeletal system or its analogs.
Chris Mungall
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes.
biomechanically related to
inverse of branching part of
Chris Mungall
RO:0002569
uberon
has_branching_part
has_branching_part
has branching part
x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
Chris Mungall
GOC:cjm
RO:0002571
uberon
lumen_of
lumen_of
lumen of
s is luminal space of x iff s is lumen_of x and s is an immaterial entity
Chris Mungall
RO:0002572
uberon
luminal_space_of
luminal_space_of
luminal space of
inverse of has skeleton
Chris Mungall
RO:0002576
uberon
skeleton_of
skeleton_of
skeleton of
Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
Chris Mungall
directly regulates (processual)
directly regulates
p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p
results in breakdown of
RO:0002588
external
results_in_assembly_of
results_in_assembly_of
results in assembly of
results_in_assembly_of
RO:0002590
external
results_in_disassembly_of
results_in_disassembly_of
results in disassembly of
results_in_disassembly_of
p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c
RO:0002592
external
results_in_organization_of
results_in_organization_of
results in organization of
A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
Chris Mungall
causal relation between material entity and a process
Inverse of 'causal agent in process'
RO:0002608
external
process_has_causal_agent
process_has_causal_agent
process has causal agent
a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.
Melissa Haendel
RO:0003000
external
uberon
produces
produces
Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue.
produces
produces
a produced_by b iff some process that occurs_in b has_output a.
Melissa Haendel
RO:0003001
external
uberon
produced_by
produced_by
produced by
produced by
produced_by
p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c.
cjm
2018-12-13T11:26:17Z
RO:0004007
external
has_primary_input_or_output
has_primary_input_or_output
has primary input or output
p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
cjm
2018-12-13T11:26:32Z
RO:0004008
external
has_primary_output
has_primary_output
has primary output
p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
cjm
2018-12-13T11:26:56Z
RO:0004009
external
has_primary_input
has_primary_input
has primary input
cjm
2018-03-13T23:55:05Z
causally upstream of or within, negative effect
cjm
2018-03-13T23:55:19Z
causally upstream of or within, positive effect
p acts on population of c iff c' is a collection, has members of type c, and p has participant c
pg
2020-06-08T17:21:33Z
RO:0012003
external
acts_on_population_of
acts_on_population_of
acts on population of
acts on population of
pg
2021-02-26T07:28:29Z
RO:0012008
external
results_in_fusion_of
results_in_fusion_of
results in fusion of
results in fusion of
q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
different in magnitude relative to
q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'.
increased in magnitude relative to
q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'.
decreased in magnitude relative to
has relative magnitude
s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round.
has cross section
p has anatomical participant c iff p has participant c, and c is an anatomical entity
cjm
2018-09-26T01:08:58Z
results in changes to anatomical or cellular structure
Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison.
TODO: Add homeomorphy axiom
ECO:0000041
SO:similar_to
sameness
similar to
correspondence
resemblance
in similarity relationship with
has_completed
A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617).
has_high_plasma_membrane_amount
A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617).
has_low_plasma_membrane_amount
has_not_completed
http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y
lacks_part
http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)
lacks_plasma_membrane_part
carries
uberon
channel_for
channel for
uberon
channels_from
channels_from
uberon
channels_into
channels_into
x is a conduit for y iff y passes through the lumen of x.
uberon
conduit_for
conduit for
uberon
extends_fibers_into
extends_fibers_into
Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity.
uberon
filtered_through
Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed
filtered through
uberon
protects
protects
x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.
uberon
proximally_connected_to
proximally connected to
uberon
sexually_homologous_to
sexually_homologous_to
c site_of p if c is the bearer of a disposition that is realized by a process that has p as part.
uberon
capable_of_has_part
site_of
site_of
uberon
subdivision_of
placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B
subdivision of
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
uberon
synapsed_by
synapsed by
uberon
transitively_connected_to
transitively_connected to
.
uberon
transitively_proximally_connected_to
transitively proximally connected to
a relation that indicates a cell line cell is a model for studying a disease.
Domain: a cell line cell
Range: a disease.
is model for
has_disease_location
contained_in
entity
Entity
entity
Julius Caesar
Verdi’s Requiem
the Second World War
your body mass index
BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
entity
continuant
Continuant
continuant
An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
continuant
occurrent
Occurrent
occurrent
An entity that has temporal parts and that happens, unfolds or develops through time.
BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
occurrent
ic
IndependentContinuant
independent continuant
a chair
a heart
a leg
a molecule
a spatial region
an atom
an orchestra.
an organism
the bottom right portion of a human torso
the interior of your mouth
A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
independent continuant
spatial region
process
Process
process
a process of cell-division, \ a beating of the heart
a process of meiosis
a process of sleeping
the course of a disease
the flight of a bird
the life of an organism
your process of aging.
An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
process
disposition
Disposition
disposition
an atom of element X has the disposition to decay to an atom of element Y
certain people have a predisposition to colon cancer
children are innately disposed to categorize objects in certain ways.
the cell wall is disposed to filter chemicals in endocytosis and exocytosis
BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]
disposition
realizable
RealizableEntity
realizable entity
the disposition of this piece of metal to conduct electricity.
the disposition of your blood to coagulate
the function of your reproductive organs
the role of being a doctor
the role of this boundary to delineate where Utah and Colorado meet
A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
realizable entity
quality
Quality
quality
the ambient temperature of this portion of air
the color of a tomato
the length of the circumference of your waist
the mass of this piece of gold.
the shape of your nose
the shape of your nostril
a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
quality
sdc
SpecificallyDependentContinuant
specifically dependent continuant
Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
of one-sided specifically dependent continuants: the mass of this tomato
of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
the disposition of this fish to decay
the function of this heart: to pump blood
the mutual dependence of proton donors and acceptors in chemical reactions [79
the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
the pink color of a medium rare piece of grilled filet mignon at its center
the role of being a doctor
the shape of this hole.
the smell of this portion of mozzarella
A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
specifically dependent continuant
role
Role
role
John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
the priest role
the role of a boundary to demarcate two neighboring administrative territories
the role of a building in serving as a military target
the role of a stone in marking a property boundary
the role of subject in a clinical trial
the student role
A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]
role
gdc
GenericallyDependentContinuant
generically dependent continuant
The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
generically dependent continuant
function
Function
function
the function of a hammer to drive in nails
the function of a heart pacemaker to regulate the beating of a heart through electricity
the function of amylase in saliva to break down starch into sugar
BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]
function
material
MaterialEntity
material entity
a flame
a forest fire
a human being
a hurricane
a photon
a puff of smoke
a sea wave
a tornado
an aggregate of human beings.
an energy wave
an epidemic
the undetached arm of a human being
An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
bfo
BFO:0000040
material entity
material entity
immaterial entity
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
CARO:0000000
Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
anatomical entity
anatomical entity
Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
CARO:0000003
Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
connected anatomical structure
An anatomical entity that has mass.
CARO:0000006
material anatomical entity
A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.
multi-cell-component structure
CARO:0001000
Examples: a bundle of neuron projections in the brain; a region neuropil in an arthropod central nervous system; a region of cortex (preikaryal rind) in an arthropod brain.
multi-cell-part structure
A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.
nerve fiber bundle
CARO:0001001
neuron projection bundle
Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
mah
10.7.2011
gross anatomical part
Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
Melissa Haendel
9/18/11
organism or virus or viroid
An anatomical structure that has more than one cell as a part.
djs93
Sun Feb 27 10:53:00 GMT 2011
CARO:0010000
multicellular anatomical structure
Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.
-1
0.000548579903
0.0
KEGG:C05359
PMID:21614077
Wikipedia:Electron
electron
chebi_ontology
Elektron
beta
beta(-)
beta-particle
e
e(-)
e-
negatron
CHEBI:10545
electron
A steroid compound with a structure based on a 19-carbon (androstane) skeleton.
chebi_ontology
C19-steroids
CHEBI:131621
C19-steroid
A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens.
chebi_ontology
dicarboxylic acids and derivatives
CHEBI:131927
dicarboxylic acids and O-substituted derivatives
A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3.
-1
(C14H20NO11)n.H2O
chebi_ontology
hyaluronan
hyaluronate polyanion
CHEBI:132153
hyaluronate
An organic group derived from any 3-oxo-Delta(4)-steroid.
0
C6H6O
94.111
94.04186
C1=C(C*)*C(CC1=O)*
chebi_ontology
a 3-oxo-Delta4-steroid group
CHEBI:136849
3-oxo-Delta(4)-steroid group
Any steroid that has beta-configuration at position 5.
chebi_ontology
5beta steroids
5beta-steroid
5beta-steroids
CHEBI:136889
5beta steroid
A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.
Wikipedia:Mineral_acid
chebi_ontology
inorganic acids
mineral acid
mineral acids
CHEBI:138103
inorganic acid
Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration.
chebi_ontology
CHEBI:138366
bile acids
Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).
Wikipedia:https://en.wikipedia.org/wiki/Gas
chebi_ontology
gas molecular entities
gaseous molecular entities
gaseous molecular entity
CHEBI:138675
gas molecular entity
-1
CH2NO2
InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)/p-1
KXDHJXZQYSOELW-UHFFFAOYSA-M
60.03212
60.00910
NC([O-])=O
Beilstein:3903503
CAS:302-11-4
Gmelin:239604
carbamate
chebi_ontology
Carbamat
Karbamat
carbamate ion
carbamic acid, ion(1-)
CHEBI:13941
carbamate
An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.
0
C7H6N2O
134.136
134.04801
C(=CC(NC(=*)*)=*)(NC(C(C)=*)=O)*
chebi_ontology
CHEBI:142163
24G7 epitope
An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group
-1
C5H8NO4
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1
WHUUTDBJXJRKMK-UHFFFAOYSA-M
146.12136
146.04588
[NH3+]C(CCC([O-])=O)C([O-])=O
Gmelin:327908
glutamate(1-)
hydrogen glutamate
chebi_ontology
2-ammoniopentanedioate
glutamate
glutamic acid monoanion
CHEBI:14321
glutamate(1-)
A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity.
CHEBI:13699
CHEBI:2377
KEGG:C00028
KEGG:C16722
Acceptor
chebi_ontology
A
Akzeptor
Hydrogen-acceptor
Oxidized donor
accepteur
CHEBI:15339
acceptor
0
O2
InChI=1S/O2/c1-2
MYMOFIZGZYHOMD-UHFFFAOYSA-N
31.99880
31.98983
O=O
CHEBI:10745
CHEBI:13416
CHEBI:23833
CHEBI:25366
CHEBI:30491
CHEBI:44742
CHEBI:7860
CAS:7782-44-7
Gmelin:485
HMDB:HMDB0001377
KEGG:C00007
KEGG:D00003
MetaCyc:OXYGEN-MOLECULE
MolBase:750
PDBeChem:OXY
PMID:10906528
PMID:16977326
PMID:18210929
PMID:18638417
PMID:19840863
PMID:7710549
PMID:9463773
Wikipedia:Oxygen
dioxygen
chebi_ontology
Disauerstoff
E 948
E-948
E948
O2
OXYGEN MOLECULE
Oxygen
[OO]
dioxygene
molecular oxygen
CHEBI:15379
dioxygen
A peptide containing ten or more amino acid residues.
C4H6N2O3R2(C2H2NOR)n
CHEBI:14860
CHEBI:8314
KEGG:C00403
Polypeptide
polypeptides
chebi_ontology
Polypeptid
polipeptido
CHEBI:15841
polypeptide
A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues.
0
(C5H8O6PR)n.C10H17O10PR2
CHEBI:13672
CHEBI:14859
CHEBI:8312
KEGG:C00419
Polynucleotide
chebi_ontology
polynucleotides
CHEBI:15986
polynucleotide
An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms.
0
H3N
InChI=1S/H3N/h1H3
QGZKDVFQNNGYKY-UHFFFAOYSA-N
17.03056
17.02655
[H]N([H])[H]
CHEBI:13405
CHEBI:13406
CHEBI:13407
CHEBI:13771
CHEBI:22533
CHEBI:44269
CHEBI:44284
CHEBI:44404
CHEBI:7434
Beilstein:3587154
CAS:7664-41-7
Drug_Central:4625
Gmelin:79
HMDB:HMDB0000051
KEGG:C00014
KEGG:D02916
KNApSAcK:C00007267
MetaCyc:AMMONIA
MolBase:930
PDBeChem:NH3
PMID:110589
PMID:11139349
PMID:11540049
PMID:11746427
PMID:11783653
PMID:13753780
PMID:14663195
PMID:15092448
PMID:15094021
PMID:15554424
PMID:15969015
PMID:16008360
PMID:16050680
PMID:16348008
PMID:16349403
PMID:16614889
PMID:16664306
PMID:16842901
PMID:17025297
PMID:17439666
PMID:17569513
PMID:17737668
PMID:18670398
PMID:22002069
PMID:22081570
PMID:22088435
PMID:22100291
PMID:22130175
PMID:22150211
PMID:22240068
PMID:22290316
PMID:22342082
PMID:22385337
PMID:22443779
PMID:22560242
Reaxys:3587154
Wikipedia:Ammonia
AMMONIA
Ammonia
ammonia
azane
chebi_ontology
Ammoniak
NH3
R-717
[NH3]
ammoniac
amoniaco
spirit of hartshorn
CHEBI:16134
ammonia
A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.
-2
O4S
InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
QAOWNCQODCNURD-UHFFFAOYSA-L
96.06360
95.95283
[O-]S([O-])(=O)=O
CHEBI:15135
CHEBI:45687
CHEBI:9335
Beilstein:3648446
CAS:14808-79-8
Gmelin:2120
HMDB:HMDB0001448
KEGG:C00059
KEGG:D05963
MetaCyc:SULFATE
PDBeChem:SO4
PMID:11200094
PMID:11452993
PMID:11581495
PMID:11798107
PMID:12166931
PMID:12668033
PMID:14597181
PMID:15093386
PMID:15984785
PMID:16186560
PMID:16345535
PMID:16347366
PMID:16348007
PMID:16483812
PMID:16534979
PMID:16656509
PMID:16742508
PMID:16742518
PMID:17120760
PMID:17420092
PMID:17439666
PMID:17709180
PMID:18398178
PMID:18815700
PMID:18846414
PMID:19047345
PMID:19244483
PMID:19544990
PMID:19628332
PMID:19812358
PMID:30398859
Reaxys:3648446
Wikipedia:Sulfate
Sulfate
sulfate
tetraoxidosulfate(2-)
tetraoxosulfate(2-)
tetraoxosulfate(VI)
chebi_ontology
SO4(2-)
SULFATE ION
Sulfate anion(2-)
Sulfate dianion
Sulfate(2-)
Sulfuric acid ion(2-)
[SO4](2-)
sulphate
sulphate ion
CHEBI:16189
sulfate
A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.
0
(C14H21NO12)n
CHEBI:14412
CHEBI:24622
CHEBI:24623
CHEBI:5772
Beilstein:8538277
CAS:9004-61-9
HMDB:HMDB0010366
KEGG:C00518
KEGG:D08043
KEGG:G10505
PMID:11122186
PMID:18056362
PMID:18290544
Reaxys:8187837
Wikipedia:Hyaluronan
Hyaluronic acid
chebi_ontology
Hyaluronsaeure
[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n
[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n
acide hyaluronique
acido hialuronico
hyaluronan
CHEBI:16336
hyaluronic acid
A naturally occurring polypeptide synthesized at the ribosome.
CHEBI:8526
KEGG:C00017
chebi_ontology
Protein
polypeptide chain
protein polypeptide chains
CHEBI:16541
protein polypeptide chain
Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.
CHEBI:15131
CHEBI:23008
CHEBI:9318
Wikipedia:Carbohydrate
carbohydrate
carbohydrates
chebi_ontology
Kohlenhydrat
Kohlenhydrate
carbohidrato
carbohidratos
glucide
glucides
glucido
glucidos
hydrates de carbone
saccharide
saccharides
saccharidum
CHEBI:16646
carbohydrate
Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
0
(C2H2NOR)nC2H3NOR
CHEBI:14753
CHEBI:25906
CHEBI:7990
KEGG:C00012
Peptide
peptides
chebi_ontology
Peptid
peptido
peptidos
CHEBI:16670
peptide
Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001.
chebi_ontology
glycans
CHEBI:167559
glycan
A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
0
C33H36N4O6
InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
BPYKTIZUTYGOLE-IFADSCNNSA-N
584.66230
584.26348
CC1=C(C=C)\C(NC1=O)=C\c1[nH]c(Cc2[nH]c(\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC(O)=O)c(CCC(O)=O)c1C
CHEBI:13898
CHEBI:22870
CHEBI:3099
Beilstein:74376
CAS:635-65-4
Gmelin:411033
HMDB:HMDB0000054
KEGG:C00486
KNApSAcK:C00029828
MetaCyc:BILIRUBIN
PMID:12799017
PMID:18442622
PMID:23763371
PMID:8605219
PMID:9587403
Reaxys:74376
Wikipedia:Bilirubin
3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid
bilirubin
chebi_ontology
1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid
2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid
2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid
8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione
Bilirubin
bilirubin(Z,Z)
bilirubin-IXalpha
CHEBI:16990
bilirubin IXalpha
High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms.
CHEBI:13302
CHEBI:21123
CHEBI:33698
CHEBI:4291
CAS:9007-49-2
KEGG:C00039
Deoxyribonucleic acid
deoxyribonucleic acids
chebi_ontology
(Deoxyribonucleotide)m
(Deoxyribonucleotide)n
(Deoxyribonucleotide)n+m
DNA
DNAn
DNAn+1
DNS
Desoxyribonukleinsaeure
deoxyribonucleic acids
desoxyribose nucleic acid
thymus nucleic acid
CHEBI:16991
deoxyribonucleic acid
A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).
0
COR2
28.010
27.99491
[*]C([*])=O
CHEBI:13427
CHEBI:13646
CHEBI:24974
CHEBI:6127
CHEBI:8742
KEGG:C01450
Wikipedia:Ketone
Ketone
ketones
chebi_ontology
Keton
R-CO-R'
a ketone
cetone
ketones
CHEBI:17087
ketone
A compound in which a carbohydrate component is covalently bound to a protein component.
CHEBI:14349
CHEBI:5481
CHEBI:5493
KEGG:C00326
Glycoprotein
glycoproteins
chebi_ontology
Glykoprotein
Glykoproteine
glicoproteina
glicoproteinas
glycoproteine
glycoproteines
CHEBI:17089
glycoprotein
An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
0
C19H28O2
InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
MUMGGOZAMZWBJJ-DYKIIFRCSA-N
288.42440
288.20893
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]
CHEBI:15214
CHEBI:26883
CHEBI:45798
CHEBI:9461
Beilstein:1915399
Beilstein:3653705
CAS:58-22-0
DrugBank:DB00624
Drug_Central:2607
Gmelin:538843
HMDB:HMDB0000234
KEGG:C00535
KEGG:D00075
KNApSAcK:C00003675
LIPID_MAPS_instance:LMST02020002
PDBeChem:TES
PMID:10438974
PMID:11786693
PMID:18900503
PMID:24498482
Reaxys:1915399
Wikipedia:Testosterone
17beta-hydroxyandrost-4-en-3-one
TESTOSTERONE
Testosterone
testosterone
chebi_ontology
17beta-Hydroxy-4-androsten-3-one
17beta-hydroxy-4-androsten-3-one
4-androsten-17beta-ol-3-one
Androderm
Testosteron
testosterona
testosterone
testosteronum
CHEBI:17347
testosterone
The carbon oxoanion resulting from the removal of a proton from carbonic acid.
-1
CHO3
InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
BVKZGUZCCUSVTD-UHFFFAOYSA-M
61.01684
60.99312
OC([O-])=O
CHEBI:13363
CHEBI:22863
CHEBI:40961
CHEBI:5589
Beilstein:3903504
CAS:71-52-3
Gmelin:49249
HMDB:HMDB0000595
KEGG:C00288
MetaCyc:HCO3
PDBeChem:BCT
PMID:17215880
PMID:17505962
PMID:18439416
PMID:28732801
PMID:29150416
PMID:29460248
PMID:29466234
PMID:4208463
Wikipedia:Bicarbonate
Hydrogencarbonate
hydrogen(trioxidocarbonate)(1-)
hydrogencarbonate
hydrogencarbonate(1-)
hydrogentrioxocarbonate(1-)
hydrogentrioxocarbonate(IV)
hydroxidodioxidocarbonate(1-)
chebi_ontology
Acid carbonate
BICARBONATE ION
Bicarbonate
HCO3(-)
HCO3-
[CO2(OH)](-)
hydrogen carbonate
CHEBI:17544
hydrogencarbonate
A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity.
CHEBI:14202
CHEBI:4697
KEGG:C01351
Donor
chebi_ontology
Donator
donneur
CHEBI:17891
donor
'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
CHEBI:14517
CHEBI:25054
CHEBI:6486
KEGG:C01356
Lipid
lipids
chebi_ontology
CHEBI:18059
lipid
Any polysaccharide containing a substantial proportion of aminomonosaccharide residues.
CHEBI:14361
CHEBI:24398
CHEBI:5495
KEGG:C02545
Wikipedia:Glycosaminoglycan
Glycosaminoglycan
glycosaminoglycan
chebi_ontology
Glykosaminoglykan
glicosaminoglicano
glycosaminoglycane
glycosaminoglycans
CHEBI:18085
glycosaminoglycan
A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues.
CHEBI:14864
CHEBI:26205
CHEBI:8322
KEGG:C00420
Polysaccharide
polysaccharides
chebi_ontology
Glycan
Glycane
Glykan
Glykane
glycans
polisacarido
polisacaridos
CHEBI:18154
polysaccharide
An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.
0
C5H9NO4
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)
WHUUTDBJXJRKMK-UHFFFAOYSA-N
147.12930
147.05316
NC(CCC(O)=O)C(O)=O
CHEBI:24314
CHEBI:5431
Beilstein:1723799
CAS:617-65-2
Gmelin:101971
KEGG:C00302
KEGG:D04341
KNApSAcK:C00001358
KNApSAcK:C00019577
PMID:15739367
PMID:17190852
PMID:24616376
PMID:24984001
Reaxys:1723799
Wikipedia:Glutamic_acid
2-aminopentanedioic acid
Glutamic acid
glutamic acid
chebi_ontology
2-Aminoglutaric acid
DL-Glutamic acid
DL-Glutaminic acid
E
Glu
Glutamate
Glutaminic acid
Glutaminsaeure
CHEBI:18237
glutamic acid
That part of DNA or RNA that may be involved in pairing.
CHEBI:13873
CHEBI:25598
CHEBI:2995
KEGG:C00701
Wikipedia:Nucleobase
chebi_ontology
Base
nucleobases
CHEBI:18282
nucleobase
A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
0
C5H9N3
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
NTYJJOPFIAHURM-UHFFFAOYSA-N
111.14518
111.07965
NCCc1c[nH]cn1
CHEBI:14401
CHEBI:24596
CHEBI:43187
CHEBI:817
Beilstein:2012
CAS:51-45-6
Drug_Central:1375
Gmelin:2968
HMDB:HMDB0000870
KEGG:C00388
KEGG:D08040
KNApSAcK:C00001414
MetaCyc:HISTAMINE
PDBeChem:HSM
PMID:16399866
PMID:19547708
PMID:19843401
PMID:22770225
PMID:24101735
Reaxys:2012
Wikipedia:Histamine
2-(1H-imidazol-4-yl)ethanamine
HISTAMINE
Histamine
chebi_ontology
1H-Imidazole-4-ethanamine
2-(4-Imidazolyl)ethylamine
CHEBI:18295
histamine
0
C24H42
InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18+,19+,20-,21+,22+,23+,24-/m1/s1
QSHQKIURKJITMZ-OBUPQJQESA-N
330.59028
330.32865
[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC
Beilstein:2048472
5beta-cholane
chebi_ontology
CHEBI:20664
5beta-cholane
An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.
acyl group
alkanoyl
chebi_ontology
acyl groups
alkanoyl group
groupe acyle
CHEBI:22221
acyl group
alkali metals
chebi_ontology
Alkalimetall
Alkalimetalle
alkali metal
metal alcalin
metal alcalino
metales alcalinos
metaux alcalins
CHEBI:22314
alkali metal atom
chebi_ontology
aminoglycans
CHEBI:22506
aminoglycan
A monoatomic or polyatomic species having one or more elementary charges of the electron.
Anion
anion
chebi_ontology
Anionen
aniones
anions
CHEBI:22563
anion
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
chebi_ontology
antioxidants
antioxydant
antoxidant
CHEBI:22586
antioxidant
A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).
KEGG:C00701
Base
base
chebi_ontology
Base1
Base2
Basen
Nucleobase
bases
CHEBI:22695
base
A sodium salt of the conjugate of any bile acid with either glycine or taurine.
KEGG:C01558
chebi_ontology
Bile acid
bile salts
CHEBI:22868
bile salt
The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid.
0
CH2NO
44.03272
44.01364
*C(N)=O
PMID:24168430
carbamoyl
chebi_ontology
-C(O)NH2
-CONH2
aminocarbonyl
carbamyl
carbamyl group
carboxamide
CHEBI:23004
carbamoyl group
0
CO
28.01010
27.99491
O=C(*)*
carbonyl
carbonyl group
chebi_ontology
>C=O
CHEBI:23019
carbonyl group
An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
Wikipedia:Cofactor_(biochemistry)
cofactor
cofactors
chebi_ontology
CHEBI:23357
cofactor
Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
molecular entity
chebi_ontology
entidad molecular
entidades moleculares
entite moleculaire
molecular entities
molekulare Entitaet
CHEBI:23367
molecular entity
chebi_ontology
Cyclopeptid
Zyklopeptid
cyclic peptides
peptide cyclique
peptido ciclico
CHEBI:23449
cyclic peptide
An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring.
chebi_ontology
diazoles
CHEBI:23677
diazole
Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
chebi_ontology
drugs
medicine
CHEBI:23888
drug
chebi_ontology
monoatomic cations
CHEBI:23906
monoatomic cation
A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
enzyme inhibitor
chebi_ontology
enzyme inhibitors
inhibidor enzimatico
inhibidores enzimaticos
inhibiteur enzymatique
inhibiteurs enzymatiques
CHEBI:23924
enzyme inhibitor
chebi_ontology
CHEBI:24384
glycogens
A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
chemical entity
chebi_ontology
CHEBI:24431
chemical entity
A role played by the molecular entity or part thereof within a biological context.
chebi_ontology
biological function
CHEBI:24432
biological role
A defined linked collection of atoms or a single atom within a molecular entity.
group
chebi_ontology
Gruppe
Rest
groupe
grupo
grupos
CHEBI:24433
group
chebi_ontology
CHEBI:24505
heparins
A cyclic compound having as ring members atoms of carbon and at least of one other element.
chebi_ontology
organic heterocycle
organic heterocyclic compounds
CHEBI:24532
organic heterocyclic compound
A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
heterodetic cyclic peptide
chebi_ontology
heterodetic cyclic peptides
peptide cyclique heterodetique
peptido ciclico heterodetico
CHEBI:24533
heterodetic cyclic peptide
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
chebi_ontology
endocrine
hormones
CHEBI:24621
hormone
Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).
chebi_ontology
CHEBI:24651
hydroxides
Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position.
chebi_ontology
hydroxy-5beta-cholanic acids
CHEBI:24663
hydroxy-5beta-cholanic acid
A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.
chebi_ontology
CHEBI:24780
imidazoles
A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
oxoacid
oxoacids
chebi_ontology
oxacids
oxiacids
oxo acid
oxy-acids
oxyacids
CHEBI:24833
oxoacid
chebi_ontology
inorganic anions
CHEBI:24834
inorganic anion
A molecular entity that contains no carbon.
chebi_ontology
anorganische Verbindungen
inorganic compounds
inorganic entity
inorganic molecular entities
inorganics
CHEBI:24835
inorganic molecular entity
chebi_ontology
inorganic oxides
CHEBI:24836
inorganic oxide
A salt is an assembly of cations and anions.
salt
chebi_ontology
Salz
Salze
ionic compound
ionic compounds
sal
sales
salts
sel
sels
CHEBI:24866
salt
chebi_ontology
monoatomic ions
CHEBI:24867
monoatomic ion
chebi_ontology
organic salts
organisches Salz
CHEBI:24868
organic salt
A molecular entity having a net electric charge.
Ion
ion
chebi_ontology
Ionen
iones
ions
CHEBI:24870
ion
chebi_ontology
CHEBI:25046
linear tetrapyrrole
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
CHEBI:26619
CHEBI:35220
metabolite
chebi_ontology
metabolites
primary metabolites
secondary metabolites
CHEBI:25212
metabolite
chebi_ontology
a metal cation
metal cations
CHEBI:25213
metal cation
A molecule all atoms of which have the same atomic number.
chebi_ontology
homoatomic molecule
homoatomic molecules
CHEBI:25362
elemental molecule
Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
molecule
chebi_ontology
Molekuel
molecula
molecules
neutral molecular compounds
CHEBI:25367
molecule
An oxoacid containing a single carboxy group.
chebi_ontology
monocarboxylic acids
CHEBI:25384
monocarboxylic acid
+1
0.00000
[*+]
chebi_ontology
monoatomic monocations
monovalent inorganic cations
CHEBI:25414
monoatomic monocation
An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.
Wikipedia:Neurotransmitter
chebi_ontology
neurotransmitters
CHEBI:25512
neurotransmitter
0
N
14.007
14.00307
WebElements:N
nitrogen
chebi_ontology
7N
N
Stickstoff
azote
nitrogen
nitrogeno
CHEBI:25555
nitrogen atom
nonmetal
chebi_ontology
Nichtmetall
Nichtmetalle
no metal
no metales
non-metal
non-metaux
nonmetal
nonmetals
CHEBI:25585
nonmetal atom
Any organic ion with a net negative charge.
chebi_ontology
organic anions
CHEBI:25696
organic anion
chebi_ontology
organic ions
CHEBI:25699
organic ion
Compounds of the general formula SO3HOR where R is an organyl group
chebi_ontology
organic sulfates
CHEBI:25704
organic sulfate
An oxide is a chemical compound of oxygen with other chemical elements.
oxide
chebi_ontology
oxides
CHEBI:25741
oxide
0
O
InChI=1S/O
QVGXLLKOCUKJST-UHFFFAOYSA-N
15.99940
15.99491
[O]
KEGG:C00007
WebElements:O
oxygen
chebi_ontology
8O
O
Sauerstoff
oxigeno
oxygen
oxygene
CHEBI:25805
oxygen atom
oxygen molecular entity
chebi_ontology
oxygen molecular entities
CHEBI:25806
oxygen molecular entity
Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine.
chebi_ontology
peptide hormones
polypeptide hormone
CHEBI:25905
peptide hormone
Any amino acid whose side chain is capable of forming one or more hydrogen bonds.
0
C2H4NO2R
74.059
74.02420
OC(C(*)N)=O
CHEBI:8283
MetaCyc:Polar-amino-acids
PMID:12016058
polar amino acid
chebi_ontology
polar amino acids
polar amino-acid
polar amino-acids
CHEBI:26167
polar amino acid
0
Na
InChI=1S/Na
KEAYESYHFKHZAL-UHFFFAOYSA-N
22.98977
22.98977
[Na]
CAS:7440-23-5
Gmelin:16221
KEGG:C01330
WebElements:Na
sodium
chebi_ontology
11Na
Na
Natrium
natrium
sodio
sodium
CHEBI:26708
sodium atom
chebi_ontology
sodium compounds
sodium molecular entities
CHEBI:26712
sodium molecular entity
Any alkali metal salt having sodium(1+) as the cation.
chebi_ontology
Natriumsalz
Natriumsalze
sodium salts
CHEBI:26714
sodium salt
An ester of an alcohol and sulfuric acid.
0
O4SR2
96.06300
95.95173
[*]OS(=O)(=O)O[*]
chebi_ontology
sulfate ester
sulfuric acid ester
sulfuric acid esters
CHEBI:26819
sulfuric ester
Salts and esters of sulfuric acid
sulfates
chebi_ontology
sulfuric acid derivative
sulphates
CHEBI:26820
sulfates
0
S
InChI=1S/S
NINIDFKCEFEMDL-UHFFFAOYSA-N
32.06600
31.97207
[S]
CAS:7704-34-9
KEGG:C00087
KEGG:D06527
PPDB:605
WebElements:S
sulfur
chebi_ontology
16S
Elemental sulfur
S
Schwefel
azufre
soufre
sulfur
sulphur
theion
CHEBI:26833
sulfur atom
sulfur molecular entity
chebi_ontology
sulfur molecular entities
CHEBI:26835
sulfur molecular entity
A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.
0
H2O4S
InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)
QAOWNCQODCNURD-UHFFFAOYSA-N
98.07948
97.96738
[H]OS(=O)(=O)O[H]
CAS:7664-93-9
Gmelin:2122
KEGG:C00059
KEGG:D05963
KNApSAcK:C00007530
MolBase:4
PMID:13568755
PMID:16122922
PMID:19397353
PMID:22047659
PMID:22136045
PMID:22204399
PMID:22267186
PMID:22296037
PMID:22364556
PMID:22435616
PPDB:606
Reaxys:2037554
Wikipedia:Sulfuric_acid
Sulfuric acid
dihydrogen tetraoxosulfate
dihydroxidodioxidosulfur
hydrogen tetraoxosulfate(2-)
hydrogen tetraoxosulfate(VI)
sulfuric acid
tetraoxosulfuric acid
chebi_ontology
Acide sulfurique
Acido sulfurico
Acidum sulfuricum
H2SO4
Schwefelsaeureloesungen
[S(OH)2O2]
[SO2(OH)2]
sulphuric acid
CHEBI:26836
sulfuric acid
A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
tetrapyrrole
tetrapyrroles
chebi_ontology
a tetrapyrrole
CHEBI:26932
tetrapyrrole
Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
Wikipedia:Micronutrient
chebi_ontology
micronutrients
trace elements
CHEBI:27027
micronutrient
A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid.
chebi_ontology
univalent acyl group
univalent carboacyl groups
univalent carboxylic acyl groups
CHEBI:27207
univalent carboacyl group
A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).
zwitterion
zwitterions
chebi_ontology
compose zwitterionique
compuestos zwitterionicos
zwitteriones
zwitterionic compounds
CHEBI:27369
zwitterion
0
C
InChI=1S/C
OKTJSMMVPCPJKN-UHFFFAOYSA-N
12.01070
12.00000
[C]
CHEBI:23009
CHEBI:3399
CAS:7440-44-0
KEGG:C06265
WebElements:C
carbon
chebi_ontology
6C
C
Carbon
Kohlenstoff
carbon
carbone
carbonium
carbono
CHEBI:27594
carbon atom
A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.
CHEBI:24379
CHEBI:5466
CAS:9005-79-2
GlyGen:G99991IU
GlyTouCan:G99991IU
HMDB:HMDB0000757
KEGG:C00182
MetaCyc:CPD0-971
Wikipedia:Glycogen
Glycogen
chebi_ontology
WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1
animal starch
liver starch
CHEBI:28087
glycogen
A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised.
0
CH3NO2
InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)
KXDHJXZQYSOELW-UHFFFAOYSA-N
61.04006
61.01638
NC(O)=O
CHEBI:22504
CHEBI:23002
CHEBI:3386
CHEBI:44573
Beilstein:1734754
CAS:463-77-4
DrugBank:DB04261
Gmelin:130345
KEGG:C01563
PDBeChem:OUT
Wikipedia:Carbamic_acid
CARBAMIC ACID
Carbamic acid
carbamic acid
chebi_ontology
Aminoameisensaeure
Aminoformic acid
Carbamate
Carbamidsaeure
CHEBI:28616
carbamic acid
An onium cation obtained by protonation of ammonia.
+1
H4N
InChI=1S/H3N/h1H3/p+1
QGZKDVFQNNGYKY-UHFFFAOYSA-O
18.03850
18.03383
[H][N+]([H])([H])[H]
CHEBI:22534
CHEBI:49783
CHEBI:7435
CAS:14798-03-9
Gmelin:84
KEGG:C01342
MetaCyc:AMMONIUM
MolBase:929
PDBeChem:NH4
PMID:11319011
PMID:11341317
PMID:12096804
PMID:14512268
PMID:14879753
PMID:16345391
PMID:16903292
PMID:17392693
PMID:18515490
PMID:19199063
PMID:19596600
PMID:19682559
PMID:19716251
PMID:21993530
PMID:22265469
PMID:22524020
PMID:22562341
PMID:22631217
Reaxys:16093784
Wikipedia:Ammonium
ammonium
azanium
chebi_ontology
Ammonium(1+)
NH4(+)
NH4+
[NH4](+)
ammonium cation
ammonium ion
CHEBI:28938
ammonium
A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid.
-2
C2O4R
88.019
87.97966
[O-]C(=O)[*]C([O-])=O
CHEBI:13632
CHEBI:23688
CHEBI:23689
CHEBI:38711
dicarboxylic acid dianion
chebi_ontology
a dicarboxylate
dicarboxylate
dicarboxylates
dicarboxylic acid dianions
CHEBI:28965
dicarboxylic acid dianion
0
CH2O3
InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)
BVKZGUZCCUSVTD-UHFFFAOYSA-N
62.02478
62.00039
OC(O)=O
CHEBI:13351
CHEBI:23017
CHEBI:23744
CHEBI:3401
CAS:463-79-6
Gmelin:25554
KEGG:C01353
PDBeChem:CO3
Carbonic acid
carbonic acid
dihydroxidooxidocarbon
chebi_ontology
Dihydrogen carbonate
H2CO3
Koehlensaeure
[CO(OH)2]
CHEBI:28976
carbonic acid
The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated.
-1
CO2R
44.00950
43.98983
[O-]C([*])=O
CHEBI:13626
CHEBI:13945
CHEBI:23026
CHEBI:58657
chebi_ontology
a carboxylate
carboxylic acid anions
carboxylic anions
CHEBI:29067
carboxylic acid anion
A monoatomic monocation obtained from sodium.
+1
Na
InChI=1S/Na/q+1
FKNQFGJONOIPTF-UHFFFAOYSA-N
22.98977
22.98922
[Na+]
CHEBI:26717
CHEBI:49766
CHEBI:9175
CAS:17341-25-2
Gmelin:15196
KEGG:C01330
PDBeChem:NA
sodium cation
sodium(1+)
sodium(1+) ion
sodium(I) cation
chebi_ontology
Na(+)
Na+
SODIUM ION
CHEBI:29101
sodium(1+)
-1
H2N
InChI=1S/H2N/h1H2/q-1
HYGWNUKOUCZBND-UHFFFAOYSA-N
16.02262
16.01927
[H][N-][H]
amide
azanide
dihydridonitrate(1-)
chebi_ontology
NH2(-)
CHEBI:29337
azanide
A divalent inorganic anion resulting from the removal of two protons from ammonia.
-2
HN
InChI=1S/HN/h1H/q-2
DZQYTNGKSBCIOE-UHFFFAOYSA-N
15.01468
15.01200
[N--][H]
azanediide
hydridonitrate(2-)
chebi_ontology
NH(2-)
imide
CHEBI:29340
hydridonitrate(2-)
+1
HO2
InChI=1S/O2/c1-2/p+1
MYMOFIZGZYHOMD-UHFFFAOYSA-O
33.00674
32.99711
[H][O+]=O
Gmelin:508
dioxidenium
hydridodioxygen(1+)
chebi_ontology
HO2(+)
HOO(+)
[HO2](+)
CHEBI:29793
hydridodioxygen(1+)
A dicarboxylic acid dianion that is the conjugate base of glutamate(1-).
-2
C5H7NO4
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2
WHUUTDBJXJRKMK-UHFFFAOYSA-L
145.11342
145.03860
NC(CCC([O-])=O)C([O-])=O
Beilstein:4134100
Gmelin:327903
Reaxys:4134100
2-aminopentanedioate
glutamate
glutamate(2-)
chebi_ontology
glutamic acid dianion
CHEBI:29987
glutamate(2-)
Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force.
0
0.0
0.0
*
CHEBI:10581
CHEBI:14383
KEGG:C00205
photon
chebi_ontology
Lichtquant
Light
foton
gamma
hnu
light quantum
CHEBI:30212
photon
Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.
KEGG:C01558
Bile acid
chebi_ontology
5beta-bile acid
5beta-bile acids
Bile salt
Gallensaeure
Gallensaeuren
bile acids
CHEBI:3098
bile acid
An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
CHEBI:22473
CHEBI:2633
KEGG:C00241
Amide
amides
chebi_ontology
CHEBI:32988
amide
Intended use of the molecular entity or part thereof by humans.
chebi_ontology
CHEBI:33232
application
A particle not known to have substructure.
elementary particle
chebi_ontology
elementary particles
CHEBI:33233
fundamental particle
A monoatomic entity is a molecular entity consisting of a single atom.
chebi_ontology
atomic entity
monoatomic entities
CHEBI:33238
monoatomic entity
chebi_ontology
oxoacid derivatives
CHEBI:33241
oxoacid derivative
chebi_ontology
inorganic hydrides
CHEBI:33242
inorganic hydride
An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system.
chebi_ontology
organic fundamental parents
organic parent hydrides
CHEBI:33245
organic fundamental parent
Any substituent group which does not contain carbon.
chebi_ontology
inorganic groups
CHEBI:33246
inorganic group
Any substituent group or skeleton containing carbon.
chebi_ontology
organic groups
CHEBI:33247
organic group
Any organic substituent group, regardless of functional type, having one free valence at a carbon atom.
organyl group
organyl groups
chebi_ontology
groupe organyle
grupo organilo
grupos organilo
CHEBI:33249
organyl group
A chemical entity constituting the smallest component of an element having the chemical properties of the element.
CHEBI:22671
CHEBI:23907
atom
chebi_ontology
atome
atomo
atoms
atomus
element
elements
CHEBI:33250
atom
A nucleus is the positively charged central portion of an atom, excluding the orbital electrons.
nucleus
chebi_ontology
Atomkern
Kern
noyau
noyau atomique
nuclei
nucleo
nucleo atomico
nucleus atomi
CHEBI:33252
atomic nucleus
Heavy nuclear particle: proton or neutron.
nucleon
chebi_ontology
Nukleon
Nukleonen
nucleons
CHEBI:33253
nucleon
A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
primary amide
primary amides
chebi_ontology
CHEBI:33256
primary amide
A molecular entity all atoms of which have the same atomic number.
chebi_ontology
homoatomic entity
homoatomic molecular entities
homoatomic molecular entity
CHEBI:33259
elemental molecular entity
chebi_ontology
CHEBI:33262
elemental oxygen
0
O2
31.999
31.98983
chebi_ontology
CHEBI:33263
diatomic oxygen
An anion consisting of more than one atom.
chebi_ontology
polyatomic anions
CHEBI:33273
polyatomic anion
chebi_ontology
chemical messenger
CHEBI:33280
molecular messenger
A nutrient is a food component that an organism uses to survive and grow.
chebi_ontology
nutrients
CHEBI:33284
nutrient
A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
chebi_ontology
heteroorganic entities
organoelement compounds
CHEBI:33285
heteroorganic entity
A substance administered to aid diagnosis of a disease.
chebi_ontology
diagnostic aid
CHEBI:33295
diagnostic agent
A molecular entity containing one or more atoms of an alkali metal.
chebi_ontology
alkali metal molecular entities
CHEBI:33296
alkali metal molecular entity
Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth.
pnictogens
chebi_ontology
group 15 elements
group V elements
nitrogenoideos
nitrogenoides
pnictogene
pnictogenes
CHEBI:33300
pnictogen
A p-block molecular entity containing any pnictogen.
pnictogen molecular entity
chebi_ontology
pnictogen molecular entities
CHEBI:33302
pnictogen molecular entity
Any p-block element belonging to the group 16 family of the periodic table.
PMID:17084588
chalcogen
chalcogens
chebi_ontology
Chalkogen
Chalkogene
anfigeno
anfigenos
calcogeno
calcogenos
chalcogene
chalcogenes
group 16 elements
group VI elements
CHEBI:33303
chalcogen
Any p-block molecular entity containing a chalcogen.
chalcogen molecular entity
chebi_ontology
chalcogen compounds
chalcogen molecular entities
CHEBI:33304
chalcogen molecular entity
group 14 elements
chebi_ontology
carbon group element
carbon group elements
carbonoides
cristallogene
cristallogenes
group IV elements
CHEBI:33306
carbon group element atom
An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table.
main group elements
chebi_ontology
Hauptgruppenelement
Hauptgruppenelemente
main group element
CHEBI:33318
main group element atom
chebi_ontology
oxoacids of sulfur
sulfur oxoacids
CHEBI:33402
sulfur oxoacid
sulfur oxoacid derivative
chebi_ontology
sulfur oxoacid derivatives
CHEBI:33424
sulfur oxoacid derivative
sulfur oxoanion
chebi_ontology
oxoanions of sulfur
sulfur oxoanions
CHEBI:33482
sulfur oxoanion
chalcogen oxoacid
chebi_ontology
chalcogen oxoacids
CHEBI:33484
chalcogen oxoacid
chalcogen oxoanion
chebi_ontology
chalcogen oxoanions
CHEBI:33485
chalcogen oxoanion
chebi_ontology
alkali metal cations
CHEBI:33504
alkali metal cation
An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity.
CHEBI:25217
CHEBI:6788
KEGG:C00050
PMID:21784043
Wikipedia:Metal
chebi_ontology
elemental metal
elemental metals
metal element
metal elements
metals
CHEBI:33521
metal atom
An amino-acid anion obtained by deprotonation of any alpha-amino acid.
alpha-amino-acid anion
chebi_ontology
alpha-amino acid anions
alpha-amino-acid anions
CHEBI:33558
alpha-amino-acid anion
chebi_ontology
s-block element
s-block elements
CHEBI:33559
s-block element atom
Any main group element atom belonging to the p-block of the periodic table.
chebi_ontology
p-block element
p-block elements
CHEBI:33560
p-block element atom
A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
0
CHO2R
45.01740
44.99765
OC([*])=O
CHEBI:13428
CHEBI:13627
CHEBI:23027
PMID:17147560
PMID:18433345
Wikipedia:Carboxylic_acid
carboxylic acid
carboxylic acids
chebi_ontology
Carbonsaeure
Carbonsaeuren
Karbonsaeure
RC(=O)OH
acide carboxylique
acides carboxyliques
acido carboxilico
acidos carboxilicos
CHEBI:33575
carboxylic acid
A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
chebi_ontology
main group compounds
main group molecular entities
CHEBI:33579
main group molecular entity
carbon group molecular entity
chebi_ontology
carbon group molecular entities
CHEBI:33582
carbon group molecular entity
Any molecule that consists of a series of atoms joined together to form a ring.
Wikipedia:Cyclic_compound
chebi_ontology
cyclic compounds
CHEBI:33595
cyclic compound
chebi_ontology
hydrogen compounds
hydrogen molecular entities
CHEBI:33608
hydrogen molecular entity
chebi_ontology
polycyclic compounds
CHEBI:33635
polycyclic compound
A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.
aromatic compounds
aromatic molecular entity
chebi_ontology
aromatics
aromatische Verbindungen
CHEBI:33655
aromatic compound
chebi_ontology
organic aromatic compounds
CHEBI:33659
organic aromatic compound
An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
s-block molecular entity
chebi_ontology
s-block compounds
s-block molecular entities
CHEBI:33674
s-block molecular entity
A main group molecular entity that contains one or more atoms of a p-block element.
chebi_ontology
p-block compounds
p-block molecular entities
p-block molecular entitiy
CHEBI:33675
p-block molecular entity
Hydrides are chemical compounds of hydrogen with other chemical elements.
chebi_ontology
CHEBI:33692
hydrides
oxygen hydride
chebi_ontology
hydrides of oxygen
oxygen hydrides
CHEBI:33693
oxygen hydride
A macromolecule formed by a living organism.
biopolymer
chebi_ontology
Biopolymere
biomacromolecules
biopolymers
CHEBI:33694
biomacromolecule
chebi_ontology
genetically encoded biomacromolecules
genetically encoded biopolymers
information biomacromolecules
information biopolymers
information macromolecule
information macromolecules
CHEBI:33695
information biomacromolecule
A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.
nucleic acids
chebi_ontology
NA
Nukleinsaeure
Nukleinsaeuren
acide nucleique
acides nucleiques
acido nucleico
acidos nucleicos
CHEBI:33696
nucleic acid
High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.
CAS:63231-63-0
ribonucleic acid
ribonucleic acids
chebi_ontology
RNA
RNS
Ribonukleinsaeure
pentosenucleic acids
ribonucleic acids
ribose nucleic acid
yeast nucleic acid
CHEBI:33697
ribonucleic acid
chebi_ontology
canonical amino-acid residue
canonical amino-acid residues
common amino acid residues
proteinogenic amino-acid residues
standard amino acid residues
standard amino-acid residues
CHEBI:33700
proteinogenic amino-acid residue
A cation consisting of more than one atom.
chebi_ontology
polyatomic cations
CHEBI:33702
polyatomic cation
An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.
0
C2H4NO2R
74.05870
74.02420
NC([*])C(O)=O
CHEBI:10208
CHEBI:13779
CHEBI:22442
CHEBI:2642
KEGG:C00045
KEGG:C05167
alpha-amino acid
chebi_ontology
Amino acid
Amino acids
alpha-amino acids
alpha-amino carboxylic acids
CHEBI:33704
alpha-amino acid
When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.
amino-acid residue
chebi_ontology
amino acid residue
amino-acid residues
CHEBI:33708
amino-acid residue
A carboxylic acid containing one or more amino groups.
CHEBI:13815
CHEBI:22477
Wikipedia:Amino_acid
chebi_ontology
Aminocarbonsaeure
Aminokarbonsaeure
Aminosaeure
amino acids
CHEBI:33709
amino acid
chebi_ontology
alpha-amino-acid residues
CHEBI:33710
alpha-amino-acid residue
carbohydrate acid
chebi_ontology
carbohydrate acids
CHEBI:33720
carbohydrate acid
carbohydrate acid anion
chebi_ontology
carbohydrate acid anions
CHEBI:33721
carbohydrate acid anion
chebi_ontology
canonical nucleoside residues
common nucleoside residues
nucleoside residue
standard nucleoside residues
CHEBI:33791
canonical nucleoside residue
chebi_ontology
N
Nuc
canonical ribonucleoside residues
common ribonucleoside residue
common ribonucleoside residues
standard ribonucleoside residues
CHEBI:33792
canonical ribonucleoside residue
chebi_ontology
canonical deoxyribonucleoside residues
common 2'-deoxyribonucleoside residue
common 2'-deoxyribonucleoside residues
dN
dNuc
standard deoxyribonucleoside residues
CHEBI:33793
canonical deoxyribonucleoside residue
An organic compound having at least one hydroxy group attached to a carbon atom.
CHEBI:64710
hydroxy compounds
chebi_ontology
organic alcohol
organic hydroxy compounds
CHEBI:33822
organic hydroxy compound
Any organic molecule that consists of atoms connected in the form of a ring.
chebi_ontology
organic cyclic compounds
CHEBI:33832
organic cyclic compound
A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).
heteroarenes
chebi_ontology
hetarenes
CHEBI:33833
heteroarene
Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion.
COMe:PRX000001
conjugated proteins
chebi_ontology
complex protein
CHEBI:33837
conjugated protein
A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
Wikipedia:Macromolecule
macromolecule
chebi_ontology
macromolecules
polymer
polymer molecule
polymers
CHEBI:33839
macromolecule
A substance used in a chemical reaction to detect, measure, examine, or produce other substances.
reagent
chebi_ontology
reactif
reactivo
reagents
CHEBI:33893
reagent
Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals.
chebi_ontology
macronutrients
CHEBI:33937
macronutrient
chebi_ontology
nitrogen hydrides
CHEBI:35106
nitrogen hydride
Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
chebi_ontology
azanes
CHEBI:35107
azane
A substance that diminishes the rate of a chemical reaction.
inhibitor
chebi_ontology
inhibidor
inhibiteur
inhibitors
CHEBI:35222
inhibitor
A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.
catalyst
chebi_ontology
Katalysator
catalizador
catalyseur
CHEBI:35223
catalyst
The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group.
amino acid zwitterion
chebi_ontology
CHEBI:35238
amino acid zwitterion
A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).
chebi_ontology
ammonium ion derivatives
azanium ion derivative
azanium ion derivatives
CHEBI:35274
ammonium ion derivative
Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.
0
C19H31R
259.450
259.24258
C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCCC4)C
CHEBI:13687
CHEBI:26768
CHEBI:9263
KEGG:C00377
MetaCyc:Steroids
Steroid
steroids
chebi_ontology
a steroid
CHEBI:35341
steroid
A 17-hydroxy steroid in which the hydroxy group at position 17 has a beta-configuration.
0
C18H29OR
261.423
261.22184
CC12CCC3C(CCC4CCCCC34[*])C1CC[C@@H]2O
CHEBI:19176
CHEBI:794
KEGG:C03051
MetaCyc:17-beta-Hydroxysteroids
17beta-hydroxy steroid
chebi_ontology
17beta-hydroxy steroids
17beta-hydroxysteroid
17beta-hydroxysteroids
CHEBI:35343
17beta-hydroxy steroid
CHEBI:24748
CHEBI:5814
KEGG:C02159
chebi_ontology
Hydroxysteroid
hydroxy steroids
hydroxysteroids
CHEBI:35350
hydroxy steroid
Any heteroorganic entity containing at least one carbon-nitrogen bond.
organonitrogen compounds
chebi_ontology
organonitrogens
CHEBI:35352
organonitrogen compound
An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen.
CHEBI:33274
CHEBI:33436
oxoanion
chebi_ontology
oxoacid anions
oxoanions
CHEBI:35406
oxoanion
A substance that reduces or suppresses inflammation.
chebi_ontology
anti-inflammatory drugs
antiinflammatory agent
antiinflammatory drug
antiinflammatory drugs
CHEBI:35472
anti-inflammatory drug
chebi_ontology
alkali metal salts
CHEBI:35479
alkali metal salt
natural product fundamental parents
chebi_ontology
CHEBI:35507
natural product fundamental parent
chebi_ontology
steroid fundamental parents
CHEBI:35508
steroid fundamental parent
0
C19H32
InChI=1S/C19H32/c1-18-11-5-7-16(18)15-9-8-14-6-3-4-12-19(14,2)17(15)10-13-18/h14-17H,3-13H2,1-2H3/t14?,15-,16-,17-,18-,19-/m0/s1
QZLYKIGBANMMBK-FZFXZXLVSA-N
260.45738
260.25040
[H][C@@]12CCC3CCCC[C@]3(C)[C@@]1([H])CC[C@]1(C)CCC[C@@]21[H]
Beilstein:5247532
CAS:24887-75-0
LIPID_MAPS_instance:LMST02020000
androstane
chebi_ontology
CHEBI:35509
androstane
0
C24H42
InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18?,19+,20-,21+,22+,23+,24-/m1/s1
QSHQKIURKJITMZ-BRPMRXRMSA-N
330.59028
330.32865
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC
cholane
chebi_ontology
CHEBI:35519
cholane
A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n.
carbon oxoanion
chebi_ontology
carbon oxoanions
oxocarbon anion
oxocarbon anions
CHEBI:35604
carbon oxoanion
chebi_ontology
carbon oxoacids
oxoacids of carbon
CHEBI:35605
carbon oxoacid
Any carboxylic acid containing two carboxy groups.
CHEBI:23692
CHEBI:36172
CHEBI:4501
KEGG:C02028
Dicarboxylic acid
chebi_ontology
dicarboxylic acids
CHEBI:35692
dicarboxylic acid
dicarboxylic acid anion
chebi_ontology
dicarboxylic acid anions
CHEBI:35693
dicarboxylic acid anion
A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.
CHEBI:23960
CHEBI:4859
KEGG:C00287
Wikipedia:Ester
Ester
chebi_ontology
esters
CHEBI:35701
ester
chebi_ontology
glycosaminoglycan sulfate
glycosaminoglycan sulfates
sulfated glycosaminoglycans
CHEBI:35722
sulfated glycosaminoglycan
chebi_ontology
carbohydrate sulfates
carbohydrate sulphates
CHEBI:35724
carbohydrate sulfate
A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated.
-1
CO2R
44.01000
43.98983
[O-]C([*])=O
CHEBI:13657
CHEBI:25382
CHEBI:3407
KEGG:C00060
chebi_ontology
Carboxylate
Monocarboxylate
a monocarboxylate
monocarboxylates
monocarboxylic acid anions
CHEBI:35757
monocarboxylic acid anion
CHEBI:24979
CHEBI:25804
chebi_ontology
keto steroids
ketosteroids
oxo steroids
oxosteroids
CHEBI:35789
oxo steroid
pnictogen hydride
chebi_ontology
pnictogen hydrides
CHEBI:35881
pnictogen hydride
CHEBI:22867
CHEBI:50419
LIPID_MAPS_class:LMST04
chebi_ontology
bile acids and derivatives
cholanoids
CHEBI:36078
cholanoid
A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome.
CHEBI:13677
CHEBI:14911
proteins
chebi_ontology
CHEBI:36080
protein
chebi_ontology
bile acid anions
CHEBI:36235
bile acid anion
A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24.
0
C24H40O2
InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17?,18+,19-,20+,21+,23+,24-/m1/s1
RPKLZQLYODPWTM-KBMWBBLPSA-N
360.57320
360.30283
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O
CAS:25312-65-6
Patent:JP2008069152
Reaxys:13246008
cholan-24-oic acid
chebi_ontology
CHEBI:36237
cholanic acid
0
C24H40O2
InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17+,18+,19-,20+,21+,23+,24-/m1/s1
RPKLZQLYODPWTM-LVVAJZGHSA-N
360.57320
360.30283
[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC(O)=O
Beilstein:3214794
CAS:546-18-9
LIPID_MAPS_instance:LMST04010441
5beta-cholan-24-oic acid
5beta-cholanic acid
chebi_ontology
(5beta)-cholan-24-oic acid
(5beta,17beta)-gamma-methylandrostane-17-butanoic acid
5beta-cholanoic acid
ursocholanic acid
CHEBI:36238
5beta-cholanic acid
Members of the class of cholanic acids based on a 5beta-cholane skeleton.
chebi_ontology
CHEBI:36248
5beta-cholanic acids
A salt of a bile acid.
chebi_ontology
bile acid salts
CHEBI:36277
bile acid salt
CHEBI:23166
CHEBI:23211
chebi_ontology
CHEBI:36278
cholanic acids
Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin).
chebi_ontology
leptons
CHEBI:36338
lepton
Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy).
chebi_ontology
baryons
CHEBI:36339
baryon
Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi.
fermion
chebi_ontology
fermions
CHEBI:36340
fermion
Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose.
boson
chebi_ontology
bosons
CHEBI:36341
boson
A particle smaller than an atom.
Wikipedia:Subatomic_particle
chebi_ontology
subatomic particles
CHEBI:36342
subatomic particle
A subatomic particle known to have substructure (i.e. consisting of smaller particles).
chebi_ontology
composite particles
CHEBI:36343
composite particle
Hadron is a subatomic particle which experiences the strong force.
chebi_ontology
hadrons
CHEBI:36344
hadron
A nucleus or any of its constituents in any of their energy states.
nuclear particle
chebi_ontology
CHEBI:36347
nuclear particle
Any molecular entity consisting of more than one atom.
chebi_ontology
polyatomic entities
CHEBI:36357
polyatomic entity
An ion consisting of more than one atom.
chebi_ontology
polyatomic ions
CHEBI:36358
polyatomic ion
Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
carbonyl compounds
chebi_ontology
CHEBI:36586
carbonyl compound
Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
oxo compounds
chebi_ontology
organic oxo compounds
CHEBI:36587
organic oxo compound
Compounds based on a biladiene skeleton.
chebi_ontology
CHEBI:36735
biladienes
A hydroxy steroid carrying a hydroxy group at position 17.
chebi_ontology
17-hydroxy steroids
CHEBI:36838
17-hydroxy steroid
chalcogen hydride
chebi_ontology
chalcogen hydrides
CHEBI:36902
chalcogen hydride
chebi_ontology
inorganic ions
CHEBI:36914
inorganic ion
chebi_ontology
inorganic cations
CHEBI:36915
inorganic cation
A monoatomic or polyatomic species having one or more elementary charges of the proton.
CHEBI:23058
CHEBI:3473
KEGG:C01373
Cation
cation
chebi_ontology
Kation
Kationen
cationes
cations
CHEBI:36916
cation
chalcocarbonic acid
chalcocarbonic acids
chebi_ontology
chalcocarbonic acids
CHEBI:36961
chalcocarbonic acid
An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
organochalcogen compound
chebi_ontology
organochalcogen compounds
CHEBI:36962
organochalcogen compound
An organochalcogen compound containing at least one carbon-oxygen bond.
PMID:17586126
organooxygen compound
chebi_ontology
organooxygen compounds
CHEBI:36963
organooxygen compound
amino-acid anion
chebi_ontology
amino acid anions
amino-acid anions
CHEBI:37022
amino-acid anion
A polysaccharide composed of glucose residues.
C12H22O11(C6H10O5)n
CHEBI:24255
CHEBI:5392
CAS:9037-91-6
KEGG:C01379
Glucan
glucan
chebi_ontology
glucans
CHEBI:37163
glucan
Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'.
homopolysaccharide
chebi_ontology
homoglycan
homopolysaccharides
CHEBI:37164
homopolysaccharide
chebi_ontology
organic hydrides
CHEBI:37175
organic hydride
mononuclear parent hydrides
chebi_ontology
mononuclear hydride
mononuclear hydrides
CHEBI:37176
mononuclear parent hydride
chebi_ontology
CHEBI:37246
elemental sodium
Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid.
CHEBI:25425
CHEBI:7011
KEGG:C05114
Mucopolysaccharide
mucopolysaccharides
chebi_ontology
Mucopolysaccharid
Mukopolysaccharid
mucopolisacarido
mucopolisacaridos
CHEBI:37395
mucopolysaccharide
An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).
CHEBI:13800
CHEBI:13801
CHEBI:22209
CHEBI:2426
KEGG:C00174
Acid
acid
chebi_ontology
Saeure
Saeuren
acide
acido
acids
CHEBI:37527
acid
A molecular entity consisting of two or more chemical elements.
chebi_ontology
chemical compound
heteroatomic molecular entities
CHEBI:37577
heteroatomic molecular entity
An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.
0
CNOR3
42.01680
41.99799
[*]C(=O)N([*])[*]
CHEBI:35354
CHEBI:35355
carboxamides
chebi_ontology
carboxamides
primary carboxamide
CHEBI:37622
carboxamide
sulfuric acid derivative
chebi_ontology
sulfuric acid derivatives
CHEBI:37826
sulfuric acid derivative
A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid.
carboacyl groups
carboxylic acyl group
chebi_ontology
carboxylic acyl groups
CHEBI:37838
carboacyl group
A compound composed of two or more pyrrole units.
Beilstein:8538310
chebi_ontology
PPys
poly(pyrrole)s
polypyrroles
CHEBI:38077
polypyrrole
Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
chebi_ontology
heterocyclic organonitrogen compounds
organonitrogen heterocyclic compounds
CHEBI:38101
organonitrogen heterocyclic compound
C4H6N2O3R2(C7H9N2O2R)n
CAS:9064-67-9
KEGG:C00211
Collagen
chebi_ontology
CHEBI:3815
Collagen
chebi_ontology
monocyclic heteroarenes
CHEBI:38179
monocyclic heteroarene
organic sodium salt
chebi_ontology
organic sodium salts
CHEBI:38700
organic sodium salt
Any dianion containing at least one carboxy group.
carboxylic acid dianion
chebi_ontology
carboxylic acid dianions
CHEBI:38716
carboxylic acid dianion
A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.
0
C207H308N56O58S
InChI=1S/C207H308N56O58S/c1-108(2)89-140(186(302)240-135(69-74-163(279)280)182(298)254-149(204(320)321)94-117-43-20-15-21-44-117)250-193(309)152-54-35-86-262(152)202(318)147(92-116-41-18-14-19-42-116)252-171(287)114(11)230-175(291)132(66-71-160(273)274)234-170(286)113(10)231-191(307)150(105-265)255-183(299)136(70-75-164(281)282)241-190(306)146(98-165(283)284)249-180(296)133(67-72-161(275)276)235-169(285)112(9)229-157(270)101-225-174(290)145(97-156(213)269)251-194(310)153-55-36-87-263(153)203(319)148(93-119-60-64-123(268)65-61-119)253-199(315)167(110(5)6)257-185(301)129(49-26-30-79-210)243-198(314)168(111(7)8)259-196(312)155-57-38-85-261(155)201(317)139(53-34-83-223-207(218)219)244-178(294)130(51-32-81-221-205(214)215)237-177(293)128(48-25-29-78-209)236-176(292)127(47-24-28-77-208)232-158(271)103-227-197(313)166(109(3)4)258-195(311)154-56-37-84-260(154)200(316)138(50-27-31-80-211)233-159(272)102-226-173(289)143(95-120-99-224-126-46-23-22-45-124(120)126)247-179(295)131(52-33-82-222-206(216)217)238-187(303)142(90-115-39-16-13-17-40-115)246-189(305)144(96-121-100-220-107-228-121)248-181(297)134(68-73-162(277)278)239-184(300)137(76-88-322-12)242-192(308)151(106-266)256-188(304)141(245-172(288)125(212)104-264)91-118-58-62-122(267)63-59-118/h13-23,39-46,58-65,99-100,107-114,125,127-155,166-168,224,264-268H,24-38,47-57,66-98,101-106,208-212H2,1-12H3,(H2,213,269)(H,220,228)(H,225,290)(H,226,289)(H,227,313)(H,229,270)(H,230,291)(H,231,307)(H,232,271)(H,233,272)(H,234,286)(H,235,285)(H,236,292)(H,237,293)(H,238,303)(H,239,300)(H,240,302)(H,241,306)(H,242,308)(H,243,314)(H,244,294)(H,245,288)(H,246,305)(H,247,295)(H,248,297)(H,249,296)(H,250,309)(H,251,310)(H,252,287)(H,253,315)(H,254,298)(H,255,299)(H,256,304)(H,257,301)(H,258,311)(H,259,312)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,320,321)(H4,214,215,221)(H4,216,217,222)(H4,218,219,223)/t112-,113-,114-,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,166-,167-,168-/m0/s1
IDLFZVILOHSSID-OVLDLUHVSA-N
4541.06600
4538.25937
CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
CAS:9002-60-2
DrugBank:DB01285
Drug_Central:4931
KEGG:C02017
KEGG:D00146
Corticotropin
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-alpha-aspartylglycyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-alpha-glutamyl-L-phenylalanine
chebi_ontology
ACTH
Adrenocorticotropic hormone
SYSMEHFRWGKPVGKKRRPVKVYPDGAEDQLAEAFPLEF
adrenocorticotropin
corticotrofina
corticotrophine
corticotrophinum
corticotropin
cortrophin
CHEBI:3892
corticotropin
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
Bronsted acid
chebi_ontology
Bronsted-Saeure
acide de Bronsted
donneur d'hydron
hydron donor
CHEBI:39141
Bronsted acid
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
Bronsted base
chebi_ontology
Bronsted-Base
accepteur d'hydron
base de Bronsted
hydron acceptor
CHEBI:39142
Bronsted base
A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct.
Lewis base
chebi_ontology
Lewis-Base
base de Lewis
donneur d'une paire d'electrons
electron donor
CHEBI:39144
Lewis base
KEGG:C02019
Cyclic ketone
cyclic ketones
chebi_ontology
CHEBI:3992
cyclic ketone
-2
CO3
InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
BVKZGUZCCUSVTD-UHFFFAOYSA-L
60.00890
59.98584
[O-]C([O-])=O
CHEBI:29201
CHEBI:41605
Beilstein:3600898
CAS:3812-32-6
Gmelin:1559
PDBeChem:CO3
carbonate
trioxidocarbonate(2-)
chebi_ontology
CARBONATE ION
CO3(2-)
Karbonat
[CO3](2-)
CHEBI:41609
carbonate
0
HO
17.00734
17.00274
*O[H]
CHEBI:24706
CHEBI:43171
PDBeChem:OH
HYDROXY GROUP
hydroxy
hydroxy group
chebi_ontology
-OH
hydroxyl
hydroxyl group
CHEBI:43176
hydroxy group
-1
HO4S
InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-1
QAOWNCQODCNURD-UHFFFAOYSA-M
97.07154
96.96010
[H]OS([O-])(=O)=O
CHEBI:29199
CHEBI:45693
Gmelin:2121
hydrogen(tetraoxidosulfate)(1-)
hydrogensulfate
hydrogensulfate(1-)
hydrogentetraoxosulfate(1-)
hydrogentetraoxosulfate(VI)
hydroxidotrioxidosulfate(1-)
chebi_ontology
HSO4(-)
HYDROGEN SULFATE
[SO3(OH)](-)
CHEBI:45696
hydrogensulfate
0
O
15.99940
15.99491
O=*
CHEBI:29353
CHEBI:44607
PDBeChem:O
OXO GROUP
oxo
chebi_ontology
=O
CHEBI:46629
oxo group
0
CHO2
45.01744
44.99765
*C(=O)O
CHEBI:23025
CHEBI:41420
PDBeChem:FMT
CARBOXY GROUP
carboxy
chebi_ontology
-C(O)OH
-CO2H
-COOH
carboxyl group
CHEBI:46883
carboxy group
Any oxo steroid where an oxo substituent is located at position 3.
0
C19H29OR
273.434
273.22184
C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCC(C4)=O)C
CHEBI:13607
CHEBI:1653
CHEBI:20182
CHEBI:71186
KEGG:C01876
MetaCyc:3-Oxosteroids
PMID:9811880
chebi_ontology
3-Oxosteroid
3-oxo steroids
3-oxosteroids
a 3-oxosteroid
CHEBI:47788
3-oxo steroid
Any steroid substituted by at least one carboxy group.
chebi_ontology
steroid acids
CHEBI:47891
steroid acid
A 3-oxo steroid conjugated to a C=C double bond at the alpha,beta position.
0
C19H27OR
271.418
271.20619
C12C(C3C(C(CC3)*)(C)CC1)CCC=4C2(CCC(C4)=O)C
CHEBI:13604
CHEBI:1626
CHEBI:20157
KEGG:C00619
MetaCyc:3-Oxo-Delta-4-Steroids
chebi_ontology
3-Oxo-delta4-steroid
3-oxo Delta(4)-steroid
3-oxo Delta(4)-steroids
3-oxo-Delta(4) steroids
a 3-oxo-Delta(4)-steroid
CHEBI:47909
3-oxo-Delta(4) steroid
chebi_ontology
Schwefeloxide
oxides of sulfur
sulfur oxides
CHEBI:48154
sulfur oxide
Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
agonist
chebi_ontology
agonista
agoniste
agonists
CHEBI:48705
agonist
0
H
InChI=1S/H
YZCKVEUIGOORGS-UHFFFAOYSA-N
1.00794
1.00783
[H]
CHEBI:24634
CHEBI:49636
WebElements:H
hydrogen
chebi_ontology
1H
H
Wasserstoff
hidrogeno
hydrogen
hydrogene
CHEBI:49637
hydrogen atom
A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.
chebi_ontology
organic amino compounds
CHEBI:50047
organic amino compound
Any hormone that is responsible for controlling sexual characteristics and reproductive function.
chebi_ontology
Geschlechtshormon
Geschlechtshormone
Sexualhormon
Sexualhormone
hormone sexuelle
hormones sexuelles
sex hormones
CHEBI:50112
sex hormone
A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
Androgen
chebi_ontology
Androgene
androgene
androgenes
androgeno
androgenos
androgens
CHEBI:50113
androgen
Any anion formed by loss of a proton from a steroid acid.
chebi_ontology
steroid acid anions
CHEBI:50160
steroid acid anion
chebi_ontology
canonical nucleotide residues
CHEBI:50297
canonical nucleotide residue
chebi_ontology
canonical deoxyribonucleotide residues
CHEBI:50298
canonical deoxyribonucleotide residue
chebi_ontology
canonical ribonucleotide residues
CHEBI:50299
canonical ribonucleotide residue
chebi_ontology
CHEBI:50312
onium compound
Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families.
onium cations
chebi_ontology
onium cations
onium ion
onium ions
CHEBI:50313
onium cation
chebi_ontology
nucleotide residues
CHEBI:50319
nucleotide residue
chebi_ontology
nucleoside residues
CHEBI:50320
nucleoside residue
A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid.
chebi_ontology
canonical amino-acid side-chain
canonical amino-acid side-chains
proteinogenic amino-acid side-chain
proteinogenic amino-acid side-chain groups
proteinogenic amino-acid side-chains
CHEBI:50325
proteinogenic amino-acid side-chain group
0
C3H5O2
73.07060
73.02895
C(CC(=O)O)*
2-carboxyethyl
chebi_ontology
glutamic acid side-chain
CHEBI:50329
2-carboxyethyl group
Any steroid based on an androstane skeleton and its derivatives.
chebi_ontology
androstanoids
CHEBI:50402
androstanoid
Any molecular entity that contains carbon.
CHEBI:25700
CHEBI:33244
chebi_ontology
organic compounds
organic entity
organic molecular entities
CHEBI:50860
organic molecular entity
A role is particular behaviour which a material entity may exhibit.
chebi_ontology
CHEBI:50906
role
A poison that interferes with the functions of the nervous system.
CHEBI:50911
Wikipedia:Neurotoxin
chebi_ontology
agente neurotoxico
nerve poison
nerve poisons
neurotoxic agent
neurotoxic agents
neurotoxicant
neurotoxins
CHEBI:50910
neurotoxin
A role played by the molecular entity or part thereof within a chemical context.
chebi_ontology
CHEBI:51086
chemical role
CHEBI:25556
CHEBI:7594
KEGG:C06061
chebi_ontology
Nitrogenous compounds
nitrogen compounds
nitrogen molecular entities
CHEBI:51143
nitrogen molecular entity
An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case.
chebi_ontology
dipolar compounds
CHEBI:51151
dipolar compound
Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s).
chebi_ontology
organodiyl groups
CHEBI:51422
organodiyl group
chebi_ontology
CHEBI:51446
organic divalent group
chebi_ontology
CHEBI:51447
organic univalent group
An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
0
C3OR4
52.03150
51.99491
[*]\C([*])=C(\[*])C([*])=O
Wikipedia:Enone
chebi_ontology
enones
CHEBI:51689
enone
A ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) or R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position.
chebi_ontology
alpha,beta-unsaturated ketones
CHEBI:51721
alpha,beta-unsaturated ketone
chebi_ontology
organic polycyclic compounds
CHEBI:51958
organic polycyclic compound
A biological role played by the molecular entity or part thereof within a biochemical context.
chebi_ontology
CHEBI:52206
biochemical role
A role played by the molecular entity or part thereof which causes the development of a pathological process.
chebi_ontology
etiopathogenetic agent
etiopathogenetic role
CHEBI:52209
aetiopathogenetic role
A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
chebi_ontology
CHEBI:52210
pharmacological role
chebi_ontology
CHEBI:52211
physiological role
Any substance introduced into a living organism with therapeutic or diagnostic purpose.
CHEBI:33293
CHEBI:33294
chebi_ontology
farmaco
medicament
pharmaceuticals
CHEBI:52217
pharmaceutical
The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
chebi_ontology
antigenic determinant
epitope function
epitope role
CHEBI:53000
epitope
A polymer carrying multiple negative charges.
chebi_ontology
polyanion
polyanions
CHEBI:53309
polyanionic macromolecule
A macromolecule containing ionic groups.
chebi_ontology
ionic polymer
polyionic macromolecule
CHEBI:53368
ionic macromolecule
A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.
0
C153H225N43O49S
InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
MASNOZXLGMXCHN-ZLPAWPGGSA-N
3482.74700
3480.61570
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
CAS:16941-32-5
CAS:9007-92-5
DrugBank:DB00040
Drug_Central:2994
KEGG:C01501
KEGG:D00116
PMID:21940356
PMID:22014161
PMID:22154917
PMID:22166985
PMID:22167521
PMID:22214853
PMID:22227186
PMID:22286080
PMID:22294753
PMID:22318544
PMID:22334714
PMID:22399501
PMID:22438981
PMID:22454291
Reaxys:13191924
Wikipedia:Glucagon
Glucagon
L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine
chebi_ontology
Glucagone
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr
glucagon
glucagonum
CHEBI:5391
glucagon
A cyclic compound having as ring members atoms of at least two different elements.
Heterocyclic compound
chebi_ontology
compuesto heterociclico
compuestos heterociclicos
heterocycle
heterocyclic compounds
CHEBI:5686
heterocyclic compound
A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3.
-2
C33H34N4O6
InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-
BPYKTIZUTYGOLE-IFADSCNNSA-L
582.64630
582.24893
CC1=C(C=C)\C(NC1=O)=C\c1[nH]c(Cc2[nH]c(\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC([O-])=O)c(CCC([O-])=O)c1C
Beilstein:4083310
chebi_ontology
2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate
bilirubin IXalpha
bilirubin dianion
CHEBI:57977
bilirubin(2-)
An ammonium ion that is the conjugate acid of histamine protonated on the side-chain nitrogen.
+1
C5H10N3
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1
NTYJJOPFIAHURM-UHFFFAOYSA-O
112.15300
112.08692
[NH3+]CCc1c[nH]cn1
2-(1H-imidazol-4-yl)ethanaminium
chebi_ontology
histamine
histaminium cation
CHEBI:58432
histaminium
An organic anion of general formula RS(=O)2O(-) where R is an organyl group.
-1
O4SR
96.06300
95.95173
[O-]S(=O)(=O)O[*]
chebi_ontology
organosulfate oxoanions
CHEBI:58958
organosulfate oxoanion
An organic anion arising from deprotonation of a acyclic tetrapyrrole compound.
chebi_ontology
acyclic tetrapyrrole anion
acyclic tetrapyrrole anions
linear tetrapyrrole anions
CHEBI:59252
linear tetrapyrrole anion
A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
chebi_ontology
nucleophile
nucleophiles
nucleophilic reagents
CHEBI:59740
nucleophilic reagent
A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
chebi_ontology
Chemische Substanz
CHEBI:59999
chemical substance
A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.
chebi_ontology
Mischung
CHEBI:60004
mixture
A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc..
Wikipedia:Polymer
Polymer
chebi_ontology
Kunststoff
CHEBI:60027
polymer
An ionic polymer is a polymer, composed of ionic macromolecules.
chebi_ontology
polyionic polymer
CHEBI:60164
ionic polymer
An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one.
chebi_ontology
a monovalent cation
CHEBI:60242
monovalent inorganic cation
Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged.
0
C2H4NO2R(C2H2NOR)n
chebi_ontology
peptide zwitterions
CHEBI:60466
peptide zwitterion
Any compound that has a nucleobase as a part.
chebi_ontology
nucleobase-containing compound
nucleobase-containing compounds
nucleobase-containing molecular entities
CHEBI:61120
nucleobase-containing molecular entity
A polymer, composed of polyanion macromolecules.
chebi_ontology
polyanion
polyanions
CHEBI:61469
polyanionic polymer
Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group.
0
C2H4NO2R
74.059
74.02420
C(C([O-])=O)(*)[NH3+]
MetaCyc:Polar-amino-acids
chebi_ontology
a polar amino acid
CHEBI:62031
polar amino acid zwitterion
A substance that removes electrons from another reactant in a redox reaction.
chebi_ontology
oxidant
oxidants
oxidiser
oxidisers
oxidising agents
oxidizer
oxidizers
oxidizing agent
oxidizing agents
CHEBI:63248
oxidising agent
Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.
chebi_ontology
carbohydrate derivatives
derivatised carbohydrate
derivatised carbohydrates
derivatized carbohydrate
derivatized carbohydrates
CHEBI:63299
carbohydrate derivative
A carbohydrate derivative that is formally obtained from a carbohydrate acid.
chebi_ontology
carbohydrate acid derivatives
CHEBI:63436
carbohydrate acid derivative
A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative.
chebi_ontology
carbohydrate acid anion derivative
carbohydrate acid anion derivatives
carbohydrate acid derivative anions
CHEBI:63551
carbohydrate acid derivative anion
Any substance which is added to food to preserve or enhance its flavour and/or appearance.
Wikipedia:Food_additive
chebi_ontology
food additives
CHEBI:64047
food additive
An organic amino compound in which an aminoalkyl group is linked to an arene.
chebi_ontology
aralkylamino compounds
CHEBI:64365
aralkylamino compound
A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.
0
C76H104N18O19S2
InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
NHXLMOGPVYXJNR-ATOGVRKGSA-N
1637.87800
1636.71666
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N
CAS:38916-34-6
Drug_Central:2997
HMDB:HMDB0013072
KEGG:C16022
KEGG:D07431
LINCS:LSM-5326
PMID:21922516
PMID:22129035
PMID:22147011
PMID:22251942
PMID:22483686
PMID:22509294
Reaxys:10148626
Wikipedia:Somatostatin
L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide
chebi_ontology
Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]
L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide
Somatostatin-1
Somatostatin-14
Synthetic growth hormone release-inhibiting hormone
somatostatin
somatostatina
somatostatine
somatostatinum
CHEBI:64628
somatostatin
An organic molecular entity containing a single carbon atom (C1).
chebi_ontology
one-carbon compounds
CHEBI:64708
one-carbon compound
Any organic molecular entity that is acidic and contains carbon in covalent linkage.
chebi_ontology
organic acids
CHEBI:64709
organic acid
Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
Wikipedia:Poison
chebi_ontology
poisonous agent
poisonous agents
poisonous substance
poisonous substances
poisons
toxic agent
toxic agents
toxic substance
toxic substances
CHEBI:64909
poison
A carbohydrate derivative that is any derivative of a polysaccharide.
chebi_ontology
polysaccharide derivatives
CHEBI:65212
polysaccharide derivative
Any compound that has anti-inflammatory effects.
chebi_ontology
anti-inflammatory agents
antiinflammatory agent
antiinflammatory agents
CHEBI:67079
anti-inflammatory agent
Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.
Wikipedia:Azole
chebi_ontology
azoles
CHEBI:68452
azole
A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.
0
C22H31NO5S
InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
DDVBPZROPPMBLW-IZGXTMSKSA-N
421.55000
421.192
[H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\C=C/C=C/CC\C(C)=C/C(=O)O2)O1
CHEBI:43626
CAS:76343-93-6
PDBeChem:LAR
PMID:10859320
PMID:12087066
PMID:17897856
PMID:19528469
PMID:20677927
PMID:22492972
PMID:22498812
PMID:3200109
PMID:3556584
PMID:9250716
Reaxys:4239363
(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one
LATRUNCULIN A
chebi_ontology
(+)-latrunculin A
(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one
LAT-A
LatA
NSC 613011
CHEBI:69136
latrunculin A
Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
chebi_ontology
organic compound
organic compounds
organic molecules
CHEBI:72695
organic molecule
A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment.
MetaCyc:Exopolysaccharides
PMID:11160795
PMID:11785425
PMID:1444258
PMID:15738217
PMID:16075348
PMID:17440912
PMID:18097339
PMID:19453747
PMID:20172021
PMID:20631870
PMID:20718297
PMID:2688547
PMID:6354590
Wikipedia:Exopolysaccharide
Wikipedia:Extracellular_polymeric_substance
chebi_ontology
exopolysaccharides
extracellular polymeric substance
extracellular polymeric substances
CHEBI:72813
exopolysaccharide
Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
chebi_ontology
eukaryotic metabolites
CHEBI:75763
eukaryotic metabolite
Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
CHEBI:77721
CHEBI:77743
chebi_ontology
animal metabolites
CHEBI:75767
animal metabolite
Any animal metabolite produced during a metabolic reaction in mammals.
CHEBI:77464
CHEBI:77744
chebi_ontology
mammalian metabolites
CHEBI:75768
mammalian metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
chebi_ontology
Mus musculus metabolite
Mus musculus metabolites
mouse metabolites
CHEBI:75771
mouse metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
CHEBI:76949
CHEBI:76951
chebi_ontology
S. cerevisiae metabolite
S. cerevisiae metabolites
S. cerevisiae secondary metabolite
S. cerevisiae secondary metabolites
Saccharomyces cerevisiae metabolites
Saccharomyces cerevisiae secondary metabolites
baker's yeast metabolite
baker's yeast metabolites
baker's yeast secondary metabolite
baker's yeast secondary metabolites
CHEBI:75772
Saccharomyces cerevisiae metabolite
Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
chebi_ontology
prokaryotic metabolites
CHEBI:75787
prokaryotic metabolite
Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
Wikipedia:Hydrolase
chebi_ontology
EC 3.* (hydrolase) inhibitors
EC 3.* inhibitor
EC 3.* inhibitors
EC 3.*.*.* inhibitor
EC 3.*.*.* inhibitors
hydrolase (EC 3.*) inhibitor
hydrolase (EC 3.*) inhibitors
hydrolase inhibitor
hydrolase inhibitors
CHEBI:76759
EC 3.* (hydrolase) inhibitor
Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).
chebi_ontology
EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor
EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors
EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor
EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors
EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors
EC 3.5.* inhibitor
EC 3.5.* inhibitors
CHEBI:76764
EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).
chebi_ontology
EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors
EC 3.5.1.* inhibitor
EC 3.5.1.* inhibitors
non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor
non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors
CHEBI:76807
EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
CHEBI:75765
CHEBI:76947
chebi_ontology
fungal metabolites
CHEBI:76946
fungal metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
CHEBI:75760
CHEBI:76970
chebi_ontology
CHEBI:76969
bacterial metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
chebi_ontology
E.coli metabolite
E.coli metabolites
Escherichia coli metabolites
CHEBI:76971
Escherichia coli metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
CHEBI:75770
CHEBI:77123
chebi_ontology
H. sapiens metabolite
H. sapiens metabolites
Homo sapiens metabolite
Homo sapiens metabolites
CHEBI:77746
human metabolite
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
Wikipedia:Amidase
chebi_ontology
EC 3.5.1.4 (amidase) inhibitors
EC 3.5.1.4 inhibitor
EC 3.5.1.4 inhibitors
N-acetylaminohydrolase inhibitor
N-acetylaminohydrolase inhibitors
acylamidase inhibitor
acylamidase inhibitors
acylamide amidohydrolase inhibitor
acylamide amidohydrolase inhibitors
amidase (EC 3.5.1.4) inhibitor
amidase (EC 3.5.1.4) inhibitors
amidase inhibitor
amidase inhibitors
amidohydrolase inhibitor
amidohydrolase inhibitors
deaminase inhibitor
deaminase inhibitors
fatty acylamidase inhibitor
fatty acylamidase inhibitors
CHEBI:77941
EC 3.5.1.4 (amidase) inhibitor
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
Wikipedia:Packaging_gas
chebi_ontology
food packaging gases
CHEBI:77974
food packaging gas
A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
chebi_ontology
dietary component
dietary components
food components
CHEBI:78295
food component
A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
Wikipedia:Refrigerant
chebi_ontology
refrigerants
CHEBI:78433
refrigerant
An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.
0
C2H4NO2R
74.059
74.02420
[NH3+]C([*])C([O-])=O
CHEBI:83409
MetaCyc:Alpha-Amino-Acids
chebi_ontology
an alpha-amino acid
CHEBI:78608
alpha-amino acid zwitterion
Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.
chebi_ontology
carbohydrates and derivatives
carbohydrates and their derivatives
CHEBI:78616
carbohydrates and carbohydrate derivatives
Any metabolite produced by all living cells.
chebi_ontology
essential metabolite
essential metabolites
fundamental metabolites
CHEBI:78675
fundamental metabolite
Any organic molecular entity that contains at least one C=C bond.
chebi_ontology
olefinic compounds
CHEBI:78840
olefinic compound
Any inorganic anion with a valency of two.
chebi_ontology
divalent inorganic anions
CHEBI:79388
divalent inorganic anion
Any inorganic anion with a valency of one.
chebi_ontology
monovalent inorganic anions
CHEBI:79389
monovalent inorganic anion
An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill.
chebi_ontology
crustacean metabolites
CHEBI:83039
crustacean metabolite
A Daphnia metabolite produced by the species Daphnia magna.
chebi_ontology
Daphnia magna metabolites
CHEBI:83056
Daphnia magna metabolite
A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia
Wikipedia:Daphnia
chebi_ontology
Daphnia metabolites
CHEBI:83057
Daphnia metabolite
A family of cyclic nonapeptide hormones found in most mammals. Synthesised in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Together with the similar neuropeptide oxytocin, they are believed to influence social cognition and behaviour.
0
C46H65N15O12S2.C46H65N13O12S2
2140.458
2138.86956
CAS:11000-17-2
KEGG:C00840
KEGG:D00101
PMID:18988842
PMID:20445498
Vasopressin
chebi_ontology
ADH
AVP
Antidiuretic hormone
Inyectable de vasopresina
Solute injectable de vasopressine
VP
Vasopressini injectio
arginine vasopressin
argipressin
beta-Hypophamine
CHEBI:9937
vasopressin
a maintaining cell culture process that keeps cell line cell alive and actively cultured.
YH
cell line cell culturing
cell line cell
A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
Yongqun He, Matthew Brush, Sirarat Sarntivijai, Alexander Diehl, Jie Zheng, Yu Lin, Bjoern Peters
A 'cell line cell' is a part of a cell line established through the passaging/selection of a primary cultured cells or the experimental modification of an existing cell line. New types of cell line cells are established after sufficient passaging of a primary culture to establish a stable and homogenous population that qualifies as a line (typically 1-20 passages), or following some spontaneous or experimental modification that confers novel characteristics to an existing line. A cell line cell typically has mutations of five or more genes compared to the original cell that derives the cell line cell. Some gene mutations may turn on some oncogenes. Cell line cells can be in active culture, stored in a quiescent state for future use (e.g. frozen in liquid nitrogen), or applied in experimental procedures.
cell line cell
suspension cell line culturing is a cell line culturing method where cells do not require a surface for growth and differentiation. This method is appropriate for cells that are adapted to suspension culture or cells that are non-adhesive (e.g. hematopoietic cells)
suspension cell line culturing
adherent cell line culturing is a cell line culturing method where cells require a surface for growth and differentiation.
adherent cell line culturing
a material processing that modifies an existing cell line cell to generate another cell line cell.
Yongqun He
cell line cell modification
a role that inheres in a cell line repository organization.
SS, YH
cell line repository role
an organization that serves as a repository of cell lines.
SS, YH
cell line repository
adherent on coated surface cell line culturing is an adherent cell line culturing method that the surface is coated with extracellular matrix component to increase adhesion properties and provide other signals needed for growth and differentiation.
adherent on coated surface cell line culturing
a cell line cell that is in the ATCC cell line repository
SS, YH, UV, SS
ATCC cell line
ATCC cell line cell
a cell line cell that is in the HyperCLDB cell line repository
SS, YH, UV, SS
HyperCLDB cell line
HyperCLDB cell line cell
an immortal human lymphocyte cell line cell that is derived from T cell.
YH
immortal human T cell line cell
adherent on feeder cells cell line culturing
adherent-patchy cell line culturing
loosely adherent cell line culturing
mouse, Swiss albino
A cell line cell that is capable of replicating a limited number of times in culture before undergoing senescence.
Yongqun He, Matthew Brush, Sirarat Sarntivijai
finite cell line cell
mortal cell line cell
immortal cell line cell
A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line.
Yongqun He, Matthew Brush, Allen Xiang, Asiyah Yu Lin, Sirarat Sarntivijai, James Malone, Jie Zheng, Tomasz Adamusiak
continuous cell line cell
permanent cell line cell
immortal cell line cell
YH
a immortal cell line that is dervied from human tissue.
immortal human cell line
immortal human cell line cell
An immortal skin-derived cell line cell that derives from cat.
Yongqun He
immortal cat cell line cell
An immortal skin-derived cell line cell that derives from frog.
Yongqun He
immortal frog cell line cell
an immortal cell line cell that is generated by fusing two different types of cells. One of the parent cells is typically a cancer cell.
Yongqun He
immortal hybrid cell line cell
An immortal cell line cell that derives from zebra fish.
Yongqun He
immortal zebra fish cell line cell
mouse immortal cell line
mouse immortal cell line cell
a cell line that requires suspension cell cuturing.
suspension cell line
suspension cell line cell
a cell line that is cultured through adherence cell culturing.
adherent cell line
adherent cell line cell
a cell culture growth mode that indicates a cell needs to adhere to a cell culture plate to grow.
YH
adherent cell culture growth mode
a cell culture growth mode that indicates a cell can grow when the cell is suspended in cell culture medium.
YH
suspension cell culture growth mode
a disposition that represents a mode of cell culture growth, i.e., the cell will grow at a specific cell culture mode. For example, an adherent cell culture growh mode means that the cell will grow when the cell is adhere to a cell culture plate.
YH
cell culture growth mode
cell line
He, Tong-Chuan, et al., Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512.: "To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene".
Note that common usage in the literature is often of the form "a human colorectal cancer cell line", as seen above. But such references to studies in "a line" refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'.
A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).
A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).
In the spring of 2013, a working group comprised of domain experts and representatives from CLO, OBI, CL, and ReO worked to establish a consensus model and definitions of cultured cells across these efforts. This included a careful characterization of how the term 'cell line' should be defined and applied. Notes about this work and its outcomes can be found on the CLO wiki here:
http://code.google.com/p/clo-ontology/wiki/Cell_Lines
MB, SS, JZ, MAH, BP, CS, YH
The term 'line' is used when a culture has undergone an intentional experimental process to establish a more uniform and stable population of cells (see 'establishing cell line'). This will require one or more passages, but may involve additional selection processes. Through such passaging and/or selection processes, the resulting 'line' attains some level of genetic stability and compositional homogeneity which is typically absent in primary cultures. Because of their relative homogeneity, ‘lines’ are capable of being characterized and stably propagated over a period of time. A new *type* of cell line can be established not only through the passaging/selection of a primary culture, but also through experimental modifications of existing lines (e.g. immortalization, stable genetic modifications, drug selection for a resistant subset, etc.).
The definition provided here establishes the 'scale' of cell populations that qualify as cell lines - specifically those with a shared propagation history in culture. In this way, the 'cell line' class demarcates populations that represent what researchers actually use in the practice of science - e.g. as inputs to culturing, experimentation, and sharing. The definition is such that cell lines will exhibit important attributes. For example, they will have a relatively homogenous cell type composition as they have experienced similar selective pressures due to their continuous co-propagation. In addition, these populations can also be characterized by a passage number, again owing to their common passaging history. As defined here, 'cell line' can refer to a population of cells in active culture, applied experimentally, or stored in a quiescent state for future use.
cell line
mixed adherent and suspension cell line culturing
mixed suspension
clusters in suspension cell line culturing
Oliver Note: this term needs precise definition. will consult term users later.
cell line co-expression
Ba/F3 Stably co-expresses EpoR and JAK2V617F EpoR and JAK2V617F constructs
Ba/F3 cell line co-expression
Ba/F3 cell line EpoR and JAK2V617F co-expression
CHO cell line co-expression
CHO Established (in your ontology) Stably transfected with Cre-beta lactamase: Cre Bla CHO cell line
CHO cell line co-expression of lactamase
suspension with feeder cells cell line culturing
suspension-multicell aggregates cell line culturing
a immortal cell line that is dervied from mouse tissue.
Yue Liu, Yongqun He
immortal mouse cell line
immortal mouse cell line cell
YH
a immortal cell line that is dervied from mouse macrophage.
immortal mouse macrophage cell line
a cell line that is derived from stem cell
ZX, YH
immortal stem cell line cell
YH
a immortal cell line that is dervied from mouse liver.
immortal mouse liver cell line
YH
a immortal cell line that is dervied from a Gorilla gorilla tissue.
immortal Gorilla gorilla cell line
immortal Gorilla gorilla cell line cell
a immortal stem cell line that is derived from somatic stem cell
ZX, YH
immortal somatic stem cell line cell
a immortal somatic stem cell line that is derived from epithelial fate stem cell
ZX, YH
immortal epithelial fate stem cell line cell
a immortal epithelial fate stem cell line that is derived from basal cell
ZX, YH
immortal basal cell line cell
a immortal somatic stem cell line that is derived from multi fate stem cell
ZX, YH
immortal multi fate stem cell line cell
a immortal multi fate stem cell line that is derived from neuronal stem cell
ZX, YH
immortal neuronal stem cell line cell
a immortal neuronal stem cell line that is derived from neuroblast
ZX, YH
immortal neuroblast cell line cell
a immortal multi fate stem cell line that is derived from mesenchymal cell
ZX, YH
immortal mesenchymal cell line cell
a cell line that is derived from non-terminally differentiated cell
ZX, YH
immortal non-terminally differentiated cell line
immortal non-terminally differentiated cell line cell
a immortal non-terminally differentiated cell line that is derived from osteoblast
ZX, YH
immortal osteoblast cell line
immortal osteoblast cell line cell
a immortal non-terminally differentiated cell line that is derived from muscle precursor cell
ZX, YH
immortal muscle precursor cell line
immortal muscle precursor cell line cell
a immortal muscle precursor cell line that is derived from myoblast
ZX, YH
immortal myoblast cell line
immortal myoblast cell line cell
a immortal myoblast cell line that is derived from fusion competent myoblast
ZX, YH
immortal fusion competent myoblast cell line
immortal fusion competent myoblast cell line cell
a cell line that is derived from secretory cell
ZX, YH
immortal secretory cell line
immortal secretory cell line cell
a immortal secretory cell line that is derived from glandular epithelial cell
ZX, YH
immortal glandular epithelial cell line cell
a immortal glandular epithelial cell line cell that is derived from chromophil cell of anterior pituitary gland
ZX, YH
immortal anterior pituitary gland chromophil cell line cell
a immortal chromophil cell line cell of anterior pituitary gland that is derived from thyrotroph
ZX, YH
immortal thyrotroph cell line cell
a immortal chromophil cell line of anterior pituitary gland that is derived from acidophil cell of pars distalis of adenohypophysis
ZX, YH
immortal pars distalis of adenohypophysis acidophil cell line cell
a immortal glandular epithelial cell line that is derived from neck cell
ZX, YH
immortal neck cell line cell
a immortal glandular epithelial cell line that is derived from glandular cell of stomach
ZX, YH
immortal glandular cell line of stomach cell
a immortal glandular cell line of stomach that is derived from parietal cell
ZX, YH
immortal parietal cell line cell
a immortal secretory cell line that is derived from exocrine cell
ZX, YH
immortal exocrine cell line
immortal exocrine cell line cell
a immortal secretory cell line that is derived from endocrine cell
ZX, YH
immortal endocrine cell line
immortal endocrine cell line cell
a immortal endocrine cell line that is derived from mast cell
ZX, YH
immortal mast cell line
immortal mast cell line cell