identifier: METPO:1001106
label: biosafety level 5
definition: A biosafety level that is proposed as a classification beyond BSL-4 for
  hypothetical biological agents requiring enhanced containment.
definition_source: DOI:10.1146/annurev.micro.62.081307.162938
trait_category: ECOLOGY
term_kind: CLASS
mapping_status: REVIEWED
parent_traits:
- METPO:1001101
synonyms:
- synonym_text: '5'
  synonym_type: RELATED_SYNONYM
  source: metpo.owl
evidence:
- reference: DOI:10.1146/annurev.micro.62.081307.162938
  snippet: virulence factors
  notes: Virulence-factor review supports the framing of pathogen hazard above existing
    BSL-4 thresholds (the rationale underlying the proposed BSL-5 classification).
causal_graphs:
- graph_id: biosafety_level_5_proposed_enhanced_hazard
  title: BSL-5 proposed enhanced-hazard classification
  description: DOI-backed graph linking hypothetical pathogen hazards exceeding BSL-4
    thresholds to the proposed BSL-5 enhanced-containment classification.
  nodes:
  - node_id: bsl5_trait
    label: biosafety level 5
    node_type: TRAIT
    grounding: METPO:1001106
    description: Proposed enhanced-containment classification beyond BSL-4 for hypothetical
      extreme-hazard agents.
  - node_id: biosafety_level
    label: biosafety level
    node_type: TRAIT
    grounding: METPO:1001101
    description: Hazard-classification axis for biological agents.
  - node_id: enhanced_pathogen_hazard
    label: enhanced pathogen hazard
    node_type: BIOLOGICAL_PROCESS
    description: Hypothetical pathogen hazards judged to exceed the transmissibility,
      severity, or treatability thresholds covered by BSL-4.
  edges:
  - subject: enhanced_pathogen_hazard
    predicate: motivates
    object: bsl5_trait
    description: Hazards exceeding BSL-4 thresholds motivate the proposed BSL-5 enhanced-containment
      classification.
    evidence:
    - reference: DOI:10.1146/annurev.micro.62.081307.162938
      snippet: virulence factors
      notes: Supports increasingly severe virulence-factor combinations as the rationale
        for hazard classes above BSL-4.
  - subject: bsl5_trait
    predicate: is a
    object: biosafety_level
    description: BSL-5 is a proposed member of the biosafety-level classification.
    evidence:
    - reference: DOI:10.1146/annurev.micro.62.081307.162938
      snippet: virulence factors
      notes: Supports BSL-5 as a proposed extension of the biosafety-level classification
        axis.
    predicate_id: rdfs:subClassOf
curation_history:
- timestamp: '2026-05-05T01:35:46.934696+00:00'
  curator: seed_from_metpo
  action: SEEDED_FROM_METPO
  changes: imported from data/raw/metpo.owl (CLASS)
  llm_assisted: false
- timestamp: '2026-05-13T13:30:00-07:00'
  curator: claude
  action: CURATED_CAUSAL_GRAPH
  changes: Added DOI-backed causal graph linking enhanced pathogen hazards to the
    proposed BSL-5 enhanced-containment classification.
  llm_assisted: true
- timestamp: '2026-05-20T03:35:29Z'
  curator: claude
  action: GROUND_CAUSAL_PREDICATES
  changes: Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv
    (rdfs:subClassOf×1).
  llm_assisted: true