identifier: traitmech:000536 label: Avs III system definition: An AVAST system in which an organism possesses a genome-encoded subtype III locus represented by DefenseFinder with Avs3A and Avs3B profiles. definition_source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000239 synonyms: - synonym_text: Avs_III synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv - synonym_text: Avs_III__Avs3A synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md - synonym_text: Avs_III__Avs3B synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md evidence: - reference: DOI:10.1126/science.aba0372 snippet: AVAST, antiviral ATPase/NTPase of the STAND superfamily notes: Gao et al. coined AVAST as an antiviral STAND ATPase/NTPase defense-system family. - reference: DOI:10.1126/science.abm4096 snippet: Avs1 to Avs3 recognize the large terminase subunit, and Avs4 recognizes the portal notes: Gao et al. support Avs3 as a phage-protein-sensing member of the AVAST receptor family. - reference: DOI:10.1126/science.abm4096 snippet: In all four cases, target recognition led to Avs protein activation and antiviral activity notes: Gao et al. connect Avs1 through Avs4 target recognition to Avs activation and antiviral activity. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Avs | 10\.1126/science\.aba0372 | Diverse enzymatic activities mediate antiviral immunity in prokaryotes | ' notes: The pinned DefenseFinder article registry maps the Avs source key to the Gao et al. pangenome-scale antiviral-immunity paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_III__Avs3A | Avs_III__Avs3A | Avs_III | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records Avs_III__Avs3A under the Avs_III model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_III__Avs3B | Avs_III__Avs3B | Avs_III | Custom | 34 |' notes: The pinned DefenseFinder HMM inventory records Avs_III__Avs3B under the Avs_III model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_III\t2\t2\tAvs_III__Avs3A, Avs_III__Avs3B\t\t\t" notes: The pinned DefenseFinder rules table models Avs_III as an Avs subsystem with Avs3A and Avs3B profiles. causal_graphs: - graph_id: avs_iii_locus_phage_protein_recognition title: Avs III loci support phage protein recognition description: Conservative system-level sketch linking an Avs_III locus to Avs3-mediated phage protein recognition and Avs III system possession. scope_status: NONMECHANISTIC scope_notes: The graph captures Avs_III at locus and Avs3 phage-protein recognition level without asserting the exact Avs3A and Avs3B component roles, direct effector activity, native host breadth, sensitive-phage breadth, or whether every DefenseFinder Avs_III prediction is a complete experimentally active Avs III locus. nodes: - node_id: avs_iii_locus label: Avs III locus node_type: GENETIC_ELEMENT description: An AVAST subtype III locus represented in DefenseFinder by Avs3A and Avs3B profiles. - node_id: avs3_phage_protein_recognition label: Avs3 phage protein recognition node_type: BIOLOGICAL_PROCESS description: Recognition of an infecting phage protein by an Avs3 antiviral STAND-family receptor. - node_id: avs_iii_system_trait label: Avs III system node_type: TRAIT grounding: traitmech:000536 description: Possession of a genome-encoded Avs III phage-defense system. - node_id: avast_system_trait label: AVAST system node_type: TRAIT grounding: traitmech:000239 description: Possession of a genome-encoded AVAST phage-defense system. edges: - subject: avs_iii_locus predicate: contributes to predicate_id: RO:0002326 object: avs3_phage_protein_recognition description: Avs III loci encode Avs3 components, and Avs3 belongs to the AVAST receptors that recognize the phage large terminase subunit. evidence: - reference: DOI:10.1126/science.abm4096 snippet: Avs1 to Avs3 recognize the large terminase subunit, and Avs4 recognizes the portal notes: Gao et al. support Avs3 as a phage-protein-sensing member of the AVAST receptor family. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_III__Avs3A | Avs_III__Avs3A | Avs_III | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records Avs_III__Avs3A under the Avs_III model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_III__Avs3B | Avs_III__Avs3B | Avs_III | Custom | 34 |' notes: The pinned DefenseFinder HMM inventory records Avs_III__Avs3B under the Avs_III model namespace. - subject: avs3_phage_protein_recognition predicate: confers predicate_id: METPO:2007700 object: avs_iii_system_trait description: The first-pass Avs III system trait is realized by Avs3 target recognition and downstream antiviral activity. evidence: - reference: DOI:10.1126/science.abm4096 snippet: Avs1 to Avs3 recognize the large terminase subunit, and Avs4 recognizes the portal notes: Gao et al. support Avs3 as a phage-protein-sensing member of the AVAST receptor family. - reference: DOI:10.1126/science.abm4096 snippet: In all four cases, target recognition led to Avs protein activation and antiviral activity notes: Gao et al. connect Avs1 through Avs4 target recognition to Avs activation and antiviral activity. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_III\t2\t2\tAvs_III__Avs3A, Avs_III__Avs3B\t\t\t" notes: The pinned DefenseFinder rules table models Avs_III as an Avs subsystem with Avs3A and Avs3B profiles. - subject: avs_iii_system_trait predicate: is a predicate_id: rdfs:subClassOf object: avast_system_trait description: Avs III system possession is an AVAST-system trait. evidence: - reference: DOI:10.1126/science.aba0372 snippet: AVAST, antiviral ATPase/NTPase of the STAND superfamily notes: Gao et al. coined AVAST as an antiviral STAND ATPase/NTPase defense-system family. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Avs | 10\.1126/science\.aba0372 | Diverse enzymatic activities mediate antiviral immunity in prokaryotes | ' notes: The pinned DefenseFinder article registry maps the Avs source key to the Gao et al. pangenome-scale antiviral-immunity paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_III\t2\t2\tAvs_III__Avs3A, Avs_III__Avs3B\t\t\t" notes: The pinned DefenseFinder rules table models Avs_III as an Avs subsystem with Avs3A and Avs3B profiles. discussions: - discussion_id: avs-iii-component-and-effector-gap prompt: Resolve the Avs3A and Avs3B component roles, direct effector chemistry, exact phage-trigger mapping, native host breadth, and sensitive-phage breadth before minting Avs III mechanism or component children. kind: KNOWLEDGE_GAP status: OPEN rationale: Gao et al. support Avs3 phage-protein recognition and Avs activation during antiviral defense, and the pinned DefenseFinder HMM inventory and rules table support Avs_III as a subtype III model with Avs3A and Avs3B profiles. This first-pass record leaves the exact component roles, downstream effector chemistry, native host breadth, sensitive-phage breadth, and profile-to-activity requirements unresolved. evidence: - reference: DOI:10.1126/science.abm4096 snippet: Avs1 to Avs3 recognize the large terminase subunit, and Avs4 recognizes the portal notes: Gao et al. support Avs3 as a phage-protein-sensing member of the AVAST receptor family. - reference: DOI:10.1126/science.abm4096 snippet: In all four cases, target recognition led to Avs protein activation and antiviral activity notes: Gao et al. connect Avs1 through Avs4 target recognition to Avs activation and antiviral activity. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_III__Avs3A | Avs_III__Avs3A | Avs_III | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records Avs_III__Avs3A under the Avs_III model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_III__Avs3B | Avs_III__Avs3B | Avs_III | Custom | 34 |' notes: The pinned DefenseFinder HMM inventory records Avs_III__Avs3B under the Avs_III model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_III\t2\t2\tAvs_III__Avs3A, Avs_III__Avs3B\t\t\t" notes: The pinned DefenseFinder rules table models Avs_III as an Avs subsystem with Avs3A and Avs3B profiles. attaches_to: - causal_graphs#avs_iii_locus_phage_protein_recognition posed_by: codex posed_date: '2026-10-02' curation_history: - timestamp: '2026-10-02T05:44:32Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted Avs III system as a DOI- and DefenseFinder-backed GENOMICS TraitRecord under the AVAST system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v413. llm_assisted: true - timestamp: '2026-10-02T05:44:33Z' curator: codex action: REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP changes: Reviewed Avs III system during initial curation and left canonical_examples empty because Gao et al. and the pinned DefenseFinder tables support the Avs_III model namespace and Avs3 phage-protein-recognition activity but not an accession-backed native microbial taxon exemplar with experimentally verified endogenous Avs III activity. No paid research was used. llm_assisted: true