identifier: traitmech:000538 label: Avs V system definition: An AVAST system in which an organism possesses a genome-encoded subtype V locus represented by DefenseFinder with an Avs5A profile. definition_source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000239 synonyms: - synonym_text: Avs_V synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv - synonym_text: Avs_V__Avs5A synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md evidence: - reference: DOI:10.1126/science.aba0372 snippet: AVAST, antiviral ATPase/NTPase of the STAND superfamily notes: Gao et al. coined AVAST as an antiviral STAND ATPase/NTPase defense-system family. - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages notes: Muralidharan et al. support treating Avs5 systems as type V AVAST systems with conserved immunity against jumbo phages. - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades notes: Muralidharan et al. connect Avs5 phage recognition to Sir2-like effector activation. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Avs | 10\.1126/science\.aba0372 | Diverse enzymatic activities mediate antiviral immunity in prokaryotes | ' notes: The pinned DefenseFinder article registry maps the Avs source key to the Gao et al. pangenome-scale antiviral-immunity paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_V__Avs5A | Avs_V__Avs5A | Avs_V | Custom | 60 |' notes: The pinned DefenseFinder HMM inventory records Avs_V__Avs5A under the Avs_V model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_V\t1\t1\tAvs_V__Avs5A\t\t\t" notes: The pinned DefenseFinder rules table models Avs_V as an Avs subsystem with an Avs5A profile. causal_graphs: - graph_id: avs_v_locus_sir2_effector_activation title: Avs V loci support Sir2-like effector activation description: Conservative system-level sketch linking an Avs_V locus to Avs5 Sir2-like effector activation and Avs V system possession. scope_status: NONMECHANISTIC scope_notes: The graph captures Avs_V at locus and Avs5 Sir2-like effector-activation level without asserting the exact Avs5A component role, JADA trigger-protein breadth, native host breadth, sensitive jumbo-phage breadth, or whether every DefenseFinder Avs_V prediction is a complete experimentally active Avs V locus. nodes: - node_id: avs_v_locus label: Avs V locus node_type: GENETIC_ELEMENT description: An AVAST subtype V locus represented in DefenseFinder by an Avs5A profile. - node_id: avs5_sir2_like_effector_activation label: Avs5 Sir2-like effector activation node_type: BIOLOGICAL_PROCESS description: Activation of an Avs5 Sir2-like effector domain after phage infection recognition. - node_id: avs_v_system_trait label: Avs V system node_type: TRAIT grounding: traitmech:000538 description: Possession of a genome-encoded Avs V phage-defense system. - node_id: avast_system_trait label: AVAST system node_type: TRAIT grounding: traitmech:000239 description: Possession of a genome-encoded AVAST phage-defense system. edges: - subject: avs_v_locus predicate: contributes to predicate_id: RO:0002326 object: avs5_sir2_like_effector_activation description: Avs V loci encode Avs5 components, and Avs5 phage-infection recognition triggers a Sir2-like effector domain. evidence: - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades notes: Muralidharan et al. connect Avs5 phage recognition to Sir2-like effector activation. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_V__Avs5A | Avs_V__Avs5A | Avs_V | Custom | 60 |' notes: The pinned DefenseFinder HMM inventory records Avs_V__Avs5A under the Avs_V model namespace. - subject: avs5_sir2_like_effector_activation predicate: confers predicate_id: METPO:2007700 object: avs_v_system_trait description: The first-pass Avs V system trait is realized by Avs5 phage recognition, Sir2-like effector activation, and conserved immunity against jumbo phages. evidence: - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages notes: Muralidharan et al. support treating Avs5 systems as type V AVAST systems with conserved immunity against jumbo phages. - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades notes: Muralidharan et al. connect Avs5 phage recognition to Sir2-like effector activation. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_V\t1\t1\tAvs_V__Avs5A\t\t\t" notes: The pinned DefenseFinder rules table models Avs_V as an Avs subsystem with an Avs5A profile. - subject: avs_v_system_trait predicate: is a predicate_id: rdfs:subClassOf object: avast_system_trait description: Avs V system possession is an AVAST-system trait. evidence: - reference: DOI:10.1126/science.aba0372 snippet: AVAST, antiviral ATPase/NTPase of the STAND superfamily notes: Gao et al. coined AVAST as an antiviral STAND ATPase/NTPase defense-system family. - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages notes: Muralidharan et al. support treating Avs5 systems as type V AVAST systems with conserved immunity against jumbo phages. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_V\t1\t1\tAvs_V__Avs5A\t\t\t" notes: The pinned DefenseFinder rules table models Avs_V as an Avs subsystem with an Avs5A profile. discussions: - discussion_id: avs-v-component-and-host-gap prompt: Resolve the Avs5A component role, exact JADA trigger breadth, native host breadth, sensitive jumbo-phage breadth, and DefenseFinder profile-to-activity requirements before minting Avs V mechanism or component children. kind: KNOWLEDGE_GAP status: OPEN rationale: Muralidharan et al. support Avs5 Sir2-like effector activation during jumbo-phage defense, and the pinned DefenseFinder HMM inventory and rules table support Avs_V as a subtype V model with an Avs5A profile. This first-pass record leaves the exact component role, JADA trigger breadth, native host breadth, sensitive jumbo-phage breadth, and profile-to-activity requirements unresolved. evidence: - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages notes: Muralidharan et al. support treating Avs5 systems as type V AVAST systems with conserved immunity against jumbo phages. - reference: DOI:10.1016/j.molcel.2026.01.004 snippet: Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades notes: Muralidharan et al. connect Avs5 phage recognition to Sir2-like effector activation. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Avs_V__Avs5A | Avs_V__Avs5A | Avs_V | Custom | 60 |' notes: The pinned DefenseFinder HMM inventory records Avs_V__Avs5A under the Avs_V model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Avs\tAvs_V\t1\t1\tAvs_V__Avs5A\t\t\t" notes: The pinned DefenseFinder rules table models Avs_V as an Avs subsystem with an Avs5A profile. attaches_to: - causal_graphs#avs_v_locus_sir2_effector_activation posed_by: codex posed_date: '2026-10-02' curation_history: - timestamp: '2026-10-02T07:21:42Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted Avs V system as a DOI- and DefenseFinder-backed GENOMICS TraitRecord under the AVAST system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v415. llm_assisted: true - timestamp: '2026-10-02T07:21:43Z' curator: codex action: REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP changes: Reviewed Avs V system during initial curation and left canonical_examples empty because Muralidharan et al. and the pinned DefenseFinder tables support Avs5 type V AVAST immunity and the Avs_V model namespace but not an accession-backed native microbial taxon exemplar tied to Avs_V__Avs5A and experimentally verified endogenous Avs V activity. No paid research was used. llm_assisted: true