identifier: traitmech:000302 label: Detocs system definition: A phage defense system in which an organism possesses a Detocs locus represented in DefenseFinder by DtcA and DtcB profiles plus optional DtcC-family profiles, with an ATP nucleosidase output that can degrade ATP and dATP upon phage infection and halt phage propagation. definition_source: DOI:10.1016/j.cell.2023.07.020 trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000209 synonyms: - synonym_text: Detocs synonym_type: EXACT_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md evidence: - reference: DOI:10.1016/j.cell.2023.07.020 snippet: By analyzing homologs of the immune ATP nucleosidase domain, we discover and characterize Detocs, a family of bacterial defense systems with a two-component phosphotransfer-signaling architecture notes: Rousset et al. discover Detocs from immune ATP nucleosidase domain homologs and name it as a bacterial defense-system family with two-component phosphotransfer-signaling architecture. - reference: DOI:10.1016/j.cell.2023.07.020 snippet: upon phage infection, degrade cellular adenosine triphosphate (ATP) and deoxyadenosine triphosphate (dATP) notes: Rousset et al. support ATP and dATP degradation as a phage-triggered bacterial immune output. - reference: DOI:10.1016/j.cell.2023.07.020 snippet: ATP and dATP degradation during infection halts phage propagation notes: Rousset et al. connect ATP and dATP degradation to inhibition of phage propagation. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: Detocs | 10\.1101/2023\.01\.24\.525353 | A conserved family of immune effectors cleaves cellular ATP upon viral infection notes: The DefenseFinder article registry maps the named Detocs system to the Rousset et al. ATP-cleavage preprint. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Detocs\tDetocs\t2\t2\tDetocs__dtcA, Detocs__dtcB\tDetocs__dtcC" notes: The DefenseFinder rules table models the core Detocs system with required dtcA and dtcB profiles and an optional dtcC profile. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Detocs__dtcA | Detocs__dtcA | Detocs | Custom | 30 |' notes: The DefenseFinder HMM inventory records dtcA under the Detocs model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Detocs__dtcB | Detocs__dtcB | Detocs | Custom | 40 |' notes: The DefenseFinder HMM inventory records dtcB under the Detocs model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Detocs__dtcC | Detocs__dtcC | Detocs | Custom | 40 |' notes: The DefenseFinder HMM inventory records dtcC under the Detocs model namespace. causal_graphs: - graph_id: detocs_locus_depletes_atp title: Detocs loci connect phage infection to ATP depletion description: Conservative system-level sketch linking possession of a Detocs locus to phage-associated ATP and dATP degradation, halted phage propagation, and the Detocs system trait without asserting the direct phage trigger or component-specific activation mechanism. scope_status: NONMECHANISTIC scope_notes: The graph captures Detocs as a named ATP-depletion anti-phage system with DtcA, DtcB, and DtcC-family DefenseFinder profiles while leaving the direct phage trigger, component-specific phosphotransfer sequence, DtcC-variant effects, and universal system boundary unresolved. nodes: - node_id: detocs_locus label: Detocs locus node_type: GENETIC_ELEMENT description: A Detocs anti-phage defense locus represented in DefenseFinder by dtcA and dtcB profiles plus an optional dtcC-family profile. - node_id: phage_associated_atp_degradation label: phage-associated ATP and dATP degradation node_type: BIOLOGICAL_PROCESS description: ATP nucleosidase-mediated degradation of cellular ATP and dATP during phage infection. - node_id: halted_phage_propagation label: halted phage propagation node_type: BIOLOGICAL_PROCESS description: Blockage of bacteriophage propagation after ATP-and-dATP degradation during infection. - node_id: detocs_system_trait label: Detocs system node_type: TRAIT grounding: traitmech:000302 description: Possession of a genome-encoded Detocs ATP-depletion phage-defense system. - node_id: phage_defense_system label: phage defense system node_type: TRAIT grounding: traitmech:000209 description: Possession of one or more genome-encoded immune systems that inhibit bacteriophage infection. edges: - subject: detocs_locus predicate: contributes to predicate_id: RO:0002326 object: phage_associated_atp_degradation description: Rousset et al. connect ATP nucleosidase-domain bacterial immune effectors to phage-associated ATP and dATP degradation and discovered Detocs from ATP nucleosidase domain homologs; DefenseFinder catalogs Detocs with dtcA, dtcB, and dtcC-family profiles. evidence: - reference: DOI:10.1016/j.cell.2023.07.020 snippet: By analyzing homologs of the immune ATP nucleosidase domain, we discover and characterize Detocs, a family of bacterial defense systems notes: Rousset et al. identify Detocs from homologs of immune ATP nucleosidase domains. - reference: DOI:10.1016/j.cell.2023.07.020 snippet: upon phage infection, degrade cellular adenosine triphosphate (ATP) and deoxyadenosine triphosphate (dATP) notes: Rousset et al. support ATP and dATP degradation as a phage-triggered bacterial immune output. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Detocs\tDetocs\t2\t2\tDetocs__dtcA, Detocs__dtcB\tDetocs__dtcC" notes: The DefenseFinder rules table models the core Detocs system with required dtcA and dtcB profiles and an optional dtcC profile. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Detocs__dtcA | Detocs__dtcA | Detocs | Custom | 30 |' notes: The DefenseFinder HMM inventory records dtcA under the Detocs model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Detocs__dtcB | Detocs__dtcB | Detocs | Custom | 40 |' notes: The DefenseFinder HMM inventory records dtcB under the Detocs model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Detocs__dtcC | Detocs__dtcC | Detocs | Custom | 40 |' notes: The DefenseFinder HMM inventory records dtcC under the Detocs model namespace. - subject: phage_associated_atp_degradation predicate: contributes to predicate_id: RO:0002326 object: halted_phage_propagation description: ATP and dATP degradation during infection contributes to halted phage propagation. evidence: - reference: DOI:10.1016/j.cell.2023.07.020 snippet: ATP and dATP degradation during infection halts phage propagation notes: Rousset et al. connect ATP and dATP degradation to halted phage propagation. - subject: halted_phage_propagation predicate: confers predicate_id: METPO:2007700 object: detocs_system_trait description: Detocs-associated ATP and dATP depletion realizes the Detocs system trait. evidence: - reference: DOI:10.1016/j.cell.2023.07.020 snippet: ATP and dATP degradation during infection halts phage propagation notes: Rousset et al. connect ATP and dATP degradation to inhibition of phage propagation. - reference: DOI:10.1016/j.cell.2023.07.020 snippet: we discover and characterize Detocs, a family of bacterial defense systems notes: Rousset et al. support Detocs as a named bacterial defense-system family. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: Detocs | 10\.1101/2023\.01\.24\.525353 | A conserved family of immune effectors cleaves cellular ATP upon viral infection notes: The DefenseFinder article registry maps the named Detocs system to the Rousset et al. ATP-cleavage preprint. - subject: detocs_system_trait predicate: is a predicate_id: rdfs:subClassOf object: phage_defense_system description: Detocs system possession is a phage-defense-system trait. evidence: - reference: DOI:10.1016/j.cell.2023.07.020 snippet: we discover and characterize Detocs, a family of bacterial defense systems notes: Rousset et al. place Detocs in a bacterial defense-system family. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: Detocs | 10\.1101/2023\.01\.24\.525353 | A conserved family of immune effectors cleaves cellular ATP upon viral infection notes: The DefenseFinder article registry maps the named Detocs system to the Rousset et al. ATP-cleavage preprint. discussions: - discussion_id: detocs-component-mechanism-gap prompt: Resolve Detocs phage triggers, component-specific phosphotransfer events, and DtcC-family effector outputs before minting narrower Detocs mechanism children. kind: KNOWLEDGE_GAP status: OPEN rationale: Rousset et al. support Detocs as a named family of two-component phosphotransfer-signaling bacterial defense systems, and DefenseFinder represents Detocs with required dtcA and dtcB profiles plus optional dtcC-family profiles. This system-level record leaves the direct phage trigger, component-specific activation route, exact ATP nucleosidase effector architecture, and DtcC-variant outputs unresolved. attaches_to: - causal_graphs#detocs_locus_depletes_atp posed_by: codex posed_date: '2026-09-20' curation_history: - timestamp: '2026-09-20T06:11:22Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted Detocs system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v179. llm_assisted: true - timestamp: '2026-09-20T06:54:24Z' curator: codex action: ADDRESS_PR_REVIEW changes: Quoted the Cell abstract sentence that names Detocs as a bacterial defense-system family and moved the Detocs phage-defense subclass edge off a weaker ATP-degradation fragment after the PR 1117 adversarial review filed issue 1119. llm_assisted: true - timestamp: '2026-09-20T07:11:29Z' curator: codex action: ADDRESS_PR_REVIEW changes: Attached direct ATP and dATP degradation evidence to the Detocs locus causal edge and halted-propagation evidence to the Detocs trait-conferral edge after the PR 1117 adversarial review filed issue 1121. llm_assisted: true