identifier: traitmech:000346 label: FS-GIY-YIG system definition: A phage defense system in which an organism possesses an FS_GIY_YIG locus represented by DefenseFinder as a single-profile model requiring FS_GIY_YIG__GIY_YIG. definition_source: DOI:10.1016/j.cell.2022.07.014 trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000209 synonyms: - synonym_text: FS_GIY_YIG synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md - synonym_text: FS_GIY_YIG__GIY_YIG synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md evidence: - reference: PMID:35985290 snippet: the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms notes: Fillol-Salom et al. support phage-inducible chromosomal islands as carriers of mobile-element defense mechanisms. - reference: PMID:35985290 snippet: These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer. notes: Fillol-Salom et al. support PICI-encoded defense systems as broad immunity determinants against phage reproduction and other mobile genetic element transfer. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: FS_GIY_YIG | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors notes: The DefenseFinder article registry maps the named FS_GIY_YIG system to the Fillol-Salom et al. PICI defense-system paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "FS_GIY_YIG\tFS_GIY_YIG\t1\t1\tFS_GIY_YIG__GIY_YIG" notes: The DefenseFinder rules table models FS_GIY_YIG as a single-profile system requiring the FS_GIY_YIG__GIY_YIG profile. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| FS_GIY_YIG__GIY_YIG | FS_GIY_YIG__GIY_YIG | FS_GIY_YIG | Custom | 100 |' notes: The DefenseFinder HMM inventory records FS_GIY_YIG__GIY_YIG under FS_GIY_YIG. causal_graphs: - graph_id: fs_giy_yig_locus_restricts_phage title: FS-GIY-YIG loci confer bacterial phage defense description: Conservative system-level sketch linking possession of an FS_GIY_YIG locus to broad mobile-element defense without asserting the unresolved phage trigger or molecular output. scope_status: NONMECHANISTIC scope_notes: The graph captures FS-GIY-YIG as a named DefenseFinder single-profile system in the Fillol-Salom PICI defense family while leaving its natural host breadth, helper-phage trigger, GIY-YIG substrate, and direct effector activity unresolved. nodes: - node_id: fs_giy_yig_locus label: FS_GIY_YIG locus node_type: GENETIC_ELEMENT description: A DefenseFinder FS_GIY_YIG phage-defense locus represented by a GIY-YIG nuclease-like profile. - node_id: pici_encoded_mobile_element_defense label: PICI-encoded mobile-element defense node_type: BIOLOGICAL_PROCESS description: Defense by phage-inducible chromosomal island loci against phage reproduction, plasmid transfer, or non-cognate PICI transfer. - node_id: fs_giy_yig_system_trait label: FS-GIY-YIG system node_type: TRAIT grounding: traitmech:000346 description: Possession of a genome-encoded FS-GIY-YIG phage-defense system. - node_id: phage_defense_system label: phage defense system node_type: TRAIT grounding: traitmech:000209 description: Possession of one or more genome-encoded immune systems that inhibit bacteriophage infection. edges: - subject: fs_giy_yig_locus predicate: contributes to predicate_id: RO:0002326 object: pici_encoded_mobile_element_defense description: DefenseFinder maps FS_GIY_YIG to the Fillol-Salom et al. PICI-encoded immunity study and models it as a single-profile system requiring a GIY-YIG nuclease-like profile. evidence: - reference: PMID:35985290 snippet: the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms notes: Fillol-Salom et al. support PICI loci as carriers of phage and mobile-element defense mechanisms. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: FS_GIY_YIG | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors notes: The DefenseFinder article registry maps the named FS_GIY_YIG system to the Fillol-Salom et al. PICI defense-system paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "FS_GIY_YIG\tFS_GIY_YIG\t1\t1\tFS_GIY_YIG__GIY_YIG" notes: The DefenseFinder rules table models FS_GIY_YIG as a single-profile system requiring the FS_GIY_YIG__GIY_YIG profile. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| FS_GIY_YIG__GIY_YIG | FS_GIY_YIG__GIY_YIG | FS_GIY_YIG | Custom | 100 |' notes: The DefenseFinder HMM inventory records FS_GIY_YIG__GIY_YIG under FS_GIY_YIG. - subject: pici_encoded_mobile_element_defense predicate: confers predicate_id: METPO:2007700 object: fs_giy_yig_system_trait description: FS_GIY_YIG-associated mobile-element defense realizes the FS-GIY-YIG system trait. evidence: - reference: PMID:35985290 snippet: These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer. notes: Fillol-Salom et al. support PICI-encoded defense systems as broad mobile-element immunity determinants. - subject: fs_giy_yig_system_trait predicate: is a predicate_id: rdfs:subClassOf object: phage_defense_system description: FS-GIY-YIG system possession is a phage-defense-system trait. evidence: - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: FS_GIY_YIG | 10\.1016/j\.cell\.2022\.07\.014 | Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors notes: The DefenseFinder article registry maps the named FS_GIY_YIG system to the Fillol-Salom et al. PICI defense-system paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "FS_GIY_YIG\tFS_GIY_YIG\t1\t1\tFS_GIY_YIG__GIY_YIG" notes: The DefenseFinder rules table models FS_GIY_YIG as a single-profile system requiring the FS_GIY_YIG__GIY_YIG profile. discussions: - discussion_id: fs-giy-yig-mechanism-gap prompt: Resolve FS_GIY_YIG natural hosts, helper-phage triggers, GIY-YIG substrates, and effector activity before minting narrower FS_GIY_YIG mechanism children. kind: KNOWLEDGE_GAP status: OPEN rationale: Fillol-Salom et al. support phage-inducible chromosomal islands as carriers of defense systems that provide broad immunity, and DefenseFinder models FS_GIY_YIG as a single-profile system. Its exact natural host breadth, helper-phage trigger, nuclease substrate, and profile-to-activity mapping remain unresolved. attaches_to: - causal_graphs#fs_giy_yig_locus_restricts_phage posed_by: codex posed_date: '2026-09-21' curation_history: - timestamp: '2026-09-21T21:36:57Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted FS-GIY-YIG system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v223. llm_assisted: true