identifier: traitmech:000558 label: Lamassu-FMO system definition: A Lamassu system in which an organism possesses a genome-encoded DefenseFinder Lamassu-FMO subtype locus represented by the Lamassu-FMO rule row requiring the Lamassu-Fam__LmuA_effector_FMO and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II profiles. definition_source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000232 synonyms: - synonym_text: Lamassu-FMO synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv - synonym_text: Lamassu-Fam__LmuA_effector_FMO synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md evidence: - reference: DOI:10.1073/pnas.2519643122 snippet: a bacterial immune system family featuring diverse effectors but a core conserved SMC-like sensor notes: Haudiquet et al. support placing Lamassu subtypes under a Lamassu family with diverse LmuA effectors and a conserved SMC-like sensor. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Lamassu-Fam | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages | ' notes: The pinned DefenseFinder article registry maps the Lamassu-Fam model namespace to a bacterial immune-systems preprint. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuA_effector_FMO | Lamassu-Fam__LmuA_effector_FMO | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records the Lamassu-Fam__LmuA_effector_FMO custom profile listed as mandatory by the Lamassu-FMO rule row. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II | Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records the Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II custom profile, which the Lamassu-FMO rule row lists as mandatory despite the HMM inventory also carrying an FMO-scoped LmuB SMC profile. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuC_acc_Lipase | Lamassu-Fam__LmuC_acc_Lipase | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records the Lamassu-Fam__LmuC_acc_Lipase custom profile, which the Lamassu-FMO rule row lists as accessory despite the HMM inventory also carrying an FMO-scoped LmuC accessory profile. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuB_SMC_FMO | Lamassu-Fam__LmuB_SMC_FMO | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records a Lamassu-Fam__LmuB_SMC_FMO custom profile that is not the LmuB SMC profile named by the pinned Lamassu-FMO rule row. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuC_acc_FMO | Lamassu-Fam__LmuC_acc_FMO | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records a Lamassu-Fam__LmuC_acc_FMO custom profile that is not the LmuC accessory profile named by the pinned Lamassu-FMO rule row. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Lamassu-Fam\tLamassu-FMO\t2\t2\tLamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II\t\ Lamassu-Fam__LmuC_acc_Lipase\tLamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease,\ \ Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_Hydrolase,\ \ Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK,\ \ Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical\t" notes: The pinned DefenseFinder rules table models Lamassu-FMO as a Lamassu-Fam subsystem requiring Lamassu-Fam__LmuA_effector_FMO and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II, with Lamassu-Fam__LmuC_acc_Lipase as an accessory profile. causal_graphs: - graph_id: lamassu_fmo_locus_subtype_defense title: Lamassu-FMO is a DefenseFinder Lamassu subtype description: Conservative subtype-level classification linking the DefenseFinder Lamassu-FMO rule-row definition to Lamassu-FMO system possession and its Lamassu parent. scope_status: NONMECHANISTIC scope_notes: The graph captures Lamassu-FMO as a DefenseFinder rule-row subtype of Lamassu system possession without asserting a Lamassu-FMO-specific antiphage process, expanding the FMO profile name, selecting between the rule-row LmuB/LmuC profiles and the FMO-scoped HMM rows, or resolving exact phage-triggered substrate chemistry, viral-DNA trigger, LmuC requirement, native host breadth, cell-death output, or whether every DefenseFinder Lamassu-FMO prediction is a complete experimentally active locus. nodes: - node_id: lamassu_fmo_system_trait label: Lamassu-FMO system node_type: TRAIT grounding: traitmech:000558 description: Possession of a genome-encoded Lamassu-FMO phage-defense system. - node_id: lamassu_system_trait label: Lamassu system node_type: TRAIT grounding: traitmech:000232 description: Possession of a genome-encoded Lamassu phage-defense system. edges: - subject: lamassu_fmo_system_trait predicate: is a predicate_id: rdfs:subClassOf object: lamassu_system_trait description: Lamassu-FMO system possession is a Lamassu-system trait. evidence: - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Lamassu-Fam | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages | ' notes: The pinned DefenseFinder article registry maps the Lamassu-Fam model namespace to a bacterial immune-systems preprint. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Lamassu-Fam\tLamassu-FMO\t2\t2" notes: The pinned DefenseFinder rules table places the Lamassu-FMO subsystem under the Lamassu-Fam system key with 2 mandatory matches and 2 genes required. discussions: - discussion_id: lamassu-fmo-activity-gap prompt: Resolve Lamassu-FMO phage triggers, native hosts, FMO effector meaning, LmuB/LmuC model rows, LmuC usage, and profile-to-activity criteria before minting enzyme, trigger, or component children. kind: KNOWLEDGE_GAP status: OPEN rationale: Haudiquet et al. support a Lamassu family with diverse LmuA effectors and a conserved SMC-like sensor, and the pinned DefenseFinder HMM inventory and rules table support Lamassu-FMO as a Lamassu-Fam subtype whose rule row requires Lamassu-Fam__LmuA_effector_FMO and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II. This first-pass record follows the rule row but leaves the relationship between its LmuB/LmuC Cap4-nuclease/Lipase profile names and the FMO-scoped Lamassu-Fam__LmuB_SMC_FMO and Lamassu-Fam__LmuC_acc_FMO HMM rows unresolved, along with exact FMO expansion and substrate chemistry, LmuC requirement, native hosts, phage triggers, cell-death output, and profile-to-activity criteria. evidence: - reference: DOI:10.1073/pnas.2519643122 snippet: a bacterial immune system family featuring diverse effectors but a core conserved SMC-like sensor notes: Haudiquet et al. support placing Lamassu subtypes under a Lamassu family with diverse LmuA effectors and a conserved SMC-like sensor. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuA_effector_FMO | Lamassu-Fam__LmuA_effector_FMO | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records the Lamassu-Fam__LmuA_effector_FMO custom profile listed as mandatory by the Lamassu-FMO rule row. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuB_SMC_FMO | Lamassu-Fam__LmuB_SMC_FMO | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records a Lamassu-Fam__LmuB_SMC_FMO custom profile that is not the LmuB SMC profile named by the pinned Lamassu-FMO rule row. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: '| Lamassu-Fam__LmuC_acc_FMO | Lamassu-Fam__LmuC_acc_FMO | Lamassu-Fam | Custom | 20 |' notes: The pinned DefenseFinder HMM inventory records a Lamassu-Fam__LmuC_acc_FMO custom profile that is not the LmuC accessory profile named by the pinned Lamassu-FMO rule row. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv snippet: "Lamassu-Fam\tLamassu-FMO\t2\t2\tLamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II\t\ Lamassu-Fam__LmuC_acc_Lipase\tLamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease,\ \ Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_Hydrolase,\ \ Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK,\ \ Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical\t" notes: The pinned DefenseFinder rules table models Lamassu-FMO as a Lamassu-Fam subsystem requiring Lamassu-Fam__LmuA_effector_FMO and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II, with Lamassu-Fam__LmuC_acc_Lipase as an accessory profile. attaches_to: - causal_graphs#lamassu_fmo_locus_subtype_defense posed_by: codex posed_date: '2026-10-02' curation_history: - timestamp: '2026-10-02T23:11:37Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted Lamassu-FMO system as a DefenseFinder-backed GENOMICS TraitRecord under the Lamassu system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record for the target local ID, placeholder METPO ID, proposal cohort, record slug, human label, DefenseFinder subsystem, or LmuA FMO profile string; the replacement placeholder is reserved in proposals/metpo_traitmech_v435. llm_assisted: true - timestamp: '2026-10-02T23:11:39Z' curator: codex action: REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP changes: Reviewed Lamassu-FMO system during initial curation and left canonical_examples empty because the pinned DefenseFinder tables support a rule-row subtype but not an accession-backed native microbial taxon exemplar tied to the Lamassu-FMO profiles and experimentally verified endogenous activity. No paid research was used. llm_assisted: true