identifier: traitmech:000284 label: Nantosuelta system definition: A phage defense system in which an organism possesses a Nantosuelta locus represented by a VCA0322 profile that can protect bacteria from bacteriophage infection. definition_source: DOI:10.1126/science.ads0768 trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000209 synonyms: - synonym_text: Nantosuelta synonym_type: EXACT_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md - synonym_text: VCA0322 synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md evidence: - reference: DOI:10.1126/science.ads0768 snippet: nearly 10% of the integron cassettes in the pandemic Vibrio cholerae strain encode novel antiphage functions notes: Darracq et al. support treating the newly discovered Vibrio cholerae SCI antiphage cassettes as bacterial anti-phage systems. - reference: DOI:10.1126/science.ads0768 snippet: Most of these novel systems have little or no similarity to previously known ones, with several providing defense through cell lysis or growth arrest notes: Darracq et al. support a conservative system record that does not assert a resolved Nantosuelta trigger, effector output, or universal pathway. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: Nantosuelta | 10\.1126/science\.ads0768 | Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems notes: The DefenseFinder model registry maps the named Nantosuelta system to the Darracq et al. SCI antiphage-system paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: Nantosuelta__VCA0322 | | Nantosuelta notes: The DefenseFinder HMM inventory records VCA0322 in the Nantosuelta model namespace. causal_graphs: - graph_id: nantosuelta_locus_restricts_phage title: Nantosuelta loci confer bacterial phage defense description: Conservative system-level sketch linking possession of a Nantosuelta locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output. scope_status: NONMECHANISTIC scope_notes: The graph captures Nantosuelta as a named SCI-derived anti-phage system with a VCA0322 DefenseFinder profile while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved. nodes: - node_id: nantosuelta_locus label: Nantosuelta locus node_type: GENETIC_ELEMENT description: A Nantosuelta anti-phage defense locus represented in DefenseFinder by a VCA0322 profile. - node_id: restricted_phage_propagation label: restricted phage propagation node_type: BIOLOGICAL_PROCESS description: Reduced propagation of bacteriophage in cells carrying the Nantosuelta system. - node_id: nantosuelta_system_trait label: Nantosuelta system node_type: TRAIT grounding: traitmech:000284 description: Possession of a genome-encoded Nantosuelta phage-defense system. - node_id: phage_defense_system label: phage defense system node_type: TRAIT grounding: traitmech:000209 description: Possession of one or more genome-encoded immune systems that inhibit bacteriophage infection. edges: - subject: nantosuelta_locus predicate: contributes to predicate_id: RO:0002326 object: restricted_phage_propagation description: DefenseFinder maps Nantosuelta to an SCI anti-phage-system discovery paper and represents Nantosuelta loci through the VCA0322 component profile. evidence: - reference: DOI:10.1126/science.ads0768 snippet: nearly 10% of the integron cassettes in the pandemic Vibrio cholerae strain encode novel antiphage functions notes: Darracq et al. describe the newly discovered antiphage-system cohort that the DefenseFinder Nantosuelta registry row maps to the Nantosuelta system. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: Nantosuelta__VCA0322 | | Nantosuelta notes: The DefenseFinder HMM inventory supports VCA0322 as the Nantosuelta component profile. - subject: restricted_phage_propagation predicate: confers predicate_id: METPO:2007700 object: nantosuelta_system_trait description: Nantosuelta-mediated phage restriction realizes the Nantosuelta system trait. evidence: - reference: DOI:10.1126/science.ads0768 snippet: Most of these novel systems have little or no similarity to previously known ones, with several providing defense through cell lysis or growth arrest notes: Darracq et al. place the Nantosuelta discovery cohort in a set of novel bacterial systems that protect against phages. - subject: nantosuelta_system_trait predicate: is a predicate_id: rdfs:subClassOf object: phage_defense_system description: Nantosuelta system possession is a phage-defense-system trait. evidence: - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: Nantosuelta | 10\.1126/science\.ads0768 | Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems notes: DefenseFinder associates Nantosuelta with the Darracq et al. bacterial antiphage-system paper. discussions: - discussion_id: nantosuelta-mechanism-gap prompt: Resolve Nantosuelta phage triggers and effector outputs before minting narrower Nantosuelta mechanism children. kind: KNOWLEDGE_GAP status: OPEN rationale: Darracq et al. and DefenseFinder support Nantosuelta as a named anti-phage system with a VCA0322 profile, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait. attaches_to: - causal_graphs#nantosuelta_locus_restricts_phage posed_by: codex posed_date: '2026-09-19' curation_history: - timestamp: '2026-09-19T15:29:21Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted Nantosuelta system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v161. llm_assisted: true - timestamp: '2026-09-19T15:47:16Z' curator: codex action: EDIT changes: 'Expanded the Nantosuelta confers-edge Darracq snippet so the stored quote includes the phage-defense clause flagged in issue #1070.' llm_assisted: true