identifier: traitmech:000499 label: Reve system definition: A phage defense system in which an organism possesses a single-gene Reve antiviral locus that is encoded by P4-like phage satellites and can protect bacteria from bacteriophage infection. definition_source: DOI:10.1093/nar/gkag898 trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000209 synonyms: - synonym_text: Reve synonym_type: EXACT_SYNONYM source: DOI:10.1093/nar/gkag898 evidence: - reference: DOI:10.1093/nar/gkag898 snippet: The Reve system is another single-gene system, with ATPase and KAP family P-loop domains notes: de Sousa et al. identify Reve as a single-gene P4 defense system with ATPase and KAP-family P-loop domain annotations. - reference: DOI:10.1093/nar/gkag898 snippet: with most (e.g. Bandua, Aernus, Toga, and Reve) providing strong protection against phages of different families notes: de Sousa et al. identify Reve among the novel P4-associated systems that provided strong protection against phage challenge. - reference: DOI:10.1093/nar/gkag898 snippet: Our experimental validation of anti-phage activity for 13 novel systems encoded by P4 confirms notes: de Sousa et al. summarize the validated P4-encoded novel-system cohort in their discussion. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Reve | 10\.64898/2026\.02\.27\.708500 | Shuttling, swapping and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites | ' notes: The pinned DefenseFinder article registry maps the Reve source key to the de Sousa et al. P4/P2 antiviral-repertoire paper preprint. causal_graphs: - graph_id: reve_locus_restricts_phage title: Reve loci confer bacterial phage defense description: Conservative system-level sketch linking possession of a Reve locus to restricted bacteriophage propagation without asserting the unresolved trigger or molecular output. scope_status: NONMECHANISTIC scope_notes: The graph captures Reve as a named single-gene P4 anti-phage system while leaving its phage trigger, molecular substrate, ATPase/P-loop role, antiviral effector output, source-locus breadth, and DefenseFinder HMM/rule model coverage unresolved. nodes: - node_id: reve_locus label: Reve locus node_type: GENETIC_ELEMENT description: A P4-associated Reve anti-phage defense locus. - node_id: restricted_phage_propagation label: restricted phage propagation node_type: BIOLOGICAL_PROCESS description: Reduced propagation of bacteriophage in cells carrying the Reve system. - node_id: reve_system_trait label: Reve system node_type: TRAIT grounding: traitmech:000499 description: Possession of a genome-encoded Reve phage-defense system. - node_id: phage_defense_system label: phage defense system node_type: TRAIT grounding: traitmech:000209 description: Possession of one or more genome-encoded immune systems that inhibit bacteriophage infection. edges: - subject: reve_locus predicate: contributes to predicate_id: RO:0002326 object: restricted_phage_propagation description: Reve loci are among the novel P4-encoded systems that reduced bacteriophage infection. evidence: - reference: DOI:10.1093/nar/gkag898 snippet: with most (e.g. Bandua, Aernus, Toga, and Reve) providing strong protection against phages of different families notes: de Sousa et al. name Reve among the novel P4 systems with antiviral phenotypes. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Reve | 10\.64898/2026\.02\.27\.708500 | Shuttling, swapping and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites | ' notes: The pinned DefenseFinder article registry maps the Reve source key to the de Sousa et al. P4/P2 antiviral-repertoire paper preprint. - subject: restricted_phage_propagation predicate: confers predicate_id: METPO:2007700 object: reve_system_trait description: Reve-mediated phage protection realizes the Reve system trait. evidence: - reference: DOI:10.1093/nar/gkag898 snippet: with most (e.g. Bandua, Aernus, Toga, and Reve) providing strong protection against phages of different families notes: de Sousa et al. connect Reve to strong protection in the novel-system validation cohort. - subject: reve_system_trait predicate: is a predicate_id: rdfs:subClassOf object: phage_defense_system description: Reve system possession is a phage-defense-system trait. evidence: - reference: DOI:10.1093/nar/gkag898 snippet: 13 novel systems encoded by P4 confirms that the contribution of defence functions to the pangenomes of P4 and P2 notes: de Sousa et al. frame Reve and its cohort as newly validated P4-encoded anti-phage defense functions. discussions: - discussion_id: reve-mechanism-and-modelling-gap prompt: Resolve Reve locus breadth, exact phage triggers, ATPase/P-loop molecular roles, direct antiviral output, source-system table rows, and DefenseFinder HMM/rule coverage before minting narrower Reve mechanism children. kind: KNOWLEDGE_GAP status: OPEN rationale: de Sousa et al. support Reve as one of the novel single-gene P4-encoded systems with experimental phage-protection activity, and the pinned DefenseFinder article registry maps the Reve source key to the corresponding preprint. The pinned HMM inventory and rules table have no exact Reve rows, and this first-pass record does not resolve the tested source locus, complete phage breadth, exact trigger, molecular output, or detection rule. evidence: - reference: DOI:10.1093/nar/gkag898 snippet: The Reve system is another single-gene system, with ATPase and KAP family P-loop domains notes: de Sousa et al. support Reve as a named single-gene defense system while leaving exact mechanism for separate review. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: '| Reve | 10\.64898/2026\.02\.27\.708500 | Shuttling, swapping and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites | ' notes: The pinned DefenseFinder article registry maps the Reve source key to the de Sousa et al. P4/P2 antiviral-repertoire paper preprint. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md notes: A structured first-pass search of the pinned DefenseFinder HMM inventory found no exact Reve row. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv notes: A structured first-pass search of the pinned DefenseFinder rules table found no exact Reve system row. attaches_to: - causal_graphs#reve_locus_restricts_phage posed_by: codex posed_date: '2026-09-30' curation_history: - timestamp: '2026-09-30T19:41:32Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted Reve system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v376. llm_assisted: true - timestamp: '2026-09-30T19:41:33Z' curator: codex action: REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP changes: Reviewed Reve system canonical_examples and left them empty because de Sousa et al. support P4-encoded Reve phage protection and a DefenseFinder article-registry row, but not a direct named native microbial isolate exemplar with experimentally verified endogenous Reve activity. No paid research was used. llm_assisted: true