identifier: traitmech:000267 label: Toutatis system definition: A phage defense system in which an organism possesses a Toutatis locus represented by TutA_VCA0446 and TutB_VCA0447 profiles that can protect bacteria from bacteriophage infection. definition_source: DOI:10.1126/science.ads0768 trait_category: GENOMICS term_kind: CLASS mapping_status: PROPOSED parent_traits: - traitmech:000209 synonyms: - synonym_text: Toutatis synonym_type: EXACT_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md - synonym_text: TutA_VCA0446 synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md - synonym_text: TutB_VCA0447 synonym_type: RELATED_SYNONYM source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md evidence: - reference: DOI:10.1126/science.ads0768 snippet: nearly 10% of the integron cassettes in the pandemic Vibrio cholerae strain encode novel antiphage functions notes: Darracq et al. support treating the newly discovered Vibrio cholerae SCI antiphage cassettes as bacterial anti-phage systems. - reference: DOI:10.1126/science.ads0768 snippet: Most of these novel systems have little or no similarity to previously known ones, with several providing defense through cell lysis or growth arrest notes: Darracq et al. support a conservative system record that does not assert a resolved Toutatis trigger, effector output, or universal pathway. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: Toutatis | 10\.1126/science\.ads0768 | Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems notes: The DefenseFinder model registry maps the named Toutatis system to the Darracq et al. SCI antiphage-system paper. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: Toutatis__TutA_VCA0446 | | Toutatis notes: The DefenseFinder HMM inventory records TutA_VCA0446 in the Toutatis model namespace. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: Toutatis__TutB_VCA0447 | | Toutatis notes: The DefenseFinder HMM inventory records TutB_VCA0447 in the Toutatis model namespace. causal_graphs: - graph_id: toutatis_locus_restricts_phage title: Toutatis loci confer bacterial phage defense description: Conservative system-level sketch linking possession of a Toutatis locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output. scope_status: NONMECHANISTIC scope_notes: The graph captures Toutatis as a named SCI-derived anti-phage system with TutA_VCA0446 and TutB_VCA0447 DefenseFinder profiles while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved. nodes: - node_id: toutatis_locus label: Toutatis locus node_type: GENETIC_ELEMENT description: A Toutatis anti-phage defense locus represented in DefenseFinder by TutA_VCA0446 and TutB_VCA0447 profiles. - node_id: restricted_phage_propagation label: restricted phage propagation node_type: BIOLOGICAL_PROCESS description: Reduced propagation of bacteriophage in cells carrying the Toutatis system. - node_id: toutatis_system_trait label: Toutatis system node_type: TRAIT grounding: traitmech:000267 description: Possession of a genome-encoded Toutatis phage-defense system. - node_id: phage_defense_system label: phage defense system node_type: TRAIT grounding: traitmech:000209 description: Possession of one or more genome-encoded immune systems that inhibit bacteriophage infection. edges: - subject: toutatis_locus predicate: contributes to predicate_id: RO:0002326 object: restricted_phage_propagation description: DefenseFinder maps Toutatis to an SCI anti-phage-system discovery paper and represents Toutatis loci through the TutA_VCA0446 and TutB_VCA0447 component profiles. evidence: - reference: DOI:10.1126/science.ads0768 snippet: nearly 10% of the integron cassettes in the pandemic Vibrio cholerae strain encode novel antiphage functions notes: Darracq et al. describe the newly discovered antiphage-system cohort that the DefenseFinder Toutatis registry row maps to the Toutatis system. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: Toutatis__TutA_VCA0446 | | Toutatis notes: The DefenseFinder HMM inventory supports TutA_VCA0446 as one Toutatis component profile. - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md snippet: Toutatis__TutB_VCA0447 | | Toutatis notes: The DefenseFinder HMM inventory supports TutB_VCA0447 as one Toutatis component profile. - subject: restricted_phage_propagation predicate: confers predicate_id: METPO:2007700 object: toutatis_system_trait description: Toutatis-mediated phage restriction realizes the Toutatis system trait. evidence: - reference: DOI:10.1126/science.ads0768 snippet: Most of these novel systems have little or no similarity to previously known ones notes: Darracq et al. place the Toutatis discovery cohort in a set of novel bacterial systems that protect against phages. - subject: toutatis_system_trait predicate: is a predicate_id: rdfs:subClassOf object: phage_defense_system description: Toutatis system possession is a phage-defense-system trait. evidence: - reference: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md snippet: Toutatis | 10\.1126/science\.ads0768 | Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems notes: DefenseFinder associates Toutatis with the Darracq et al. bacterial antiphage-system paper. discussions: - discussion_id: toutatis-mechanism-gap prompt: Resolve Toutatis phage triggers and effector outputs before minting narrower Toutatis mechanism children. kind: KNOWLEDGE_GAP status: OPEN rationale: Darracq et al. and DefenseFinder support Toutatis as a named anti-phage system with TutA_VCA0446 and TutB_VCA0447 profiles, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait. attaches_to: - causal_graphs#toutatis_locus_restricts_phage posed_by: codex posed_date: '2026-09-19' curation_history: - timestamp: '2026-09-19T06:05:05Z' curator: codex action: MINTED_TRAITMECH_ID changes: Minted Toutatis system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v144. llm_assisted: true