identifier: traitmech:000195
label: arsenate respiration
definition: An anaerobic respiration in which an organism uses arsenate as the terminal
  electron acceptor and reduces it to arsenite for energy conservation.
definition_source: DOI:10.1073/pnas.1834303100
trait_category: METABOLISM
term_kind: CLASS
mapping_status: PROPOSED
parent_traits:
- METPO:1000802
synonyms:
- synonym_text: As(V) respiration
  synonym_type: EXACT_SYNONYM
  source: DOI:10.1073/pnas.1834303100
- synonym_text: respiratory As(V) reduction
  synonym_type: RELATED_SYNONYM
  source: DOI:10.1073/pnas.1834303100
evidence:
- reference: DOI:10.1073/pnas.1834303100
  snippet: can be used by microorganisms as a terminal electron acceptor in anaerobic
    respiration
  notes: Saltikov and Newman define the organism-level scope as microbial anaerobic
    respiration using arsenate, As(V), as a terminal electron acceptor.
- reference: DOI:10.1128/AEM.69.5.2800-2809.2003
  snippet: This gram-negative strain stoichiometrically couples the oxidation of lactate
    to acetate with the reduction of As(V) to arsenite
  notes: Saltikov et al. isolated and characterized ANA-3 as a facultatively anaerobic
    As(V)-respiring Shewanella strain.
- reference: DOI:10.1128/JB.01110-07
  snippet: the Shewanella sp. strain ANA-3 arsenate respiratory reductase (ARR), the
    key enzyme involved in this metabolism
  notes: Malasarn et al. biochemically characterize ARR as the arsenate respiratory
    reductase for ANA-3 arsenate respiration.
canonical_examples:
- taxon_id: NCBITaxon:94122
  taxon_label: Shewanella sp. ANA-3
  note: Facultatively anaerobic Shewanella isolate characterized for arsenate-respiration
    studies.
  reference: DOI:10.1128/AEM.69.5.2800-2809.2003
discussions:
- discussion_id: arsenate-respiration-xref-gap
  prompt: Resolve an exact external ontology class for organism-level arsenate respiration
    before adding a TraitRecord xref.
  kind: CURATION_TODO
  status: OPEN
  rationale: The pinned METPO snapshot contains obsolete arsenate reduction and arsenate-reducing
    classes but no active organism-level arsenate respiration class. Potential GO,
    Rhea, EC, and protein-family terms for respiratory arsenate reductase are narrower
    than the whole-organism anaerobic respiration phenotype, and future groundings
    must keep ArrAB respiratory reduction separate from ArsC cytosolic detoxification.
  posed_by: codex
  posed_date: '2026-09-14'
curation_history:
- timestamp: '2026-09-14T23:52:00Z'
  curator: codex
  action: MINTED_TRAITMECH_ID
  changes: Minted arsenate respiration as a DOI-backed anaerobic respiration TraitRecord
    after a repository-wide duplicate review covering ignored and hidden files; the
    local METPO snapshot has only obsolete arsenate-reduction classes and the replacement
    placeholder is reserved in proposals/metpo_traitmech_v72.
  llm_assisted: true
- timestamp: '2026-09-15T00:08:31Z'
  curator: codex
  action: TIGHTENED_CANONICAL_EXAMPLE
  changes: Tightened the ANA-3 canonical example note to the DOI-backed isolation
    and facultative arsenate-respiration evidence without making a broader genetic-tractability
    claim.
  llm_assisted: true