identifier: METPO:2000303
label: does not show activity of
definition: An OBJECT_PROPERTY asserting that an organism does NOT show the
  catalytic activity of a given enzyme (material entity) class. Negation
  companion of 'shows activity of'. Intended use is predicate + class
  composition at assertion time with a METPO enzyme class (METPO:1000527 or
  its subclass) as the object.
definition_source: PMID:21413255
trait_category: METABOLISM
term_kind: OBJECT_PROPERTY
mapping_status: REVIEWED
parent_traits:
- METPO:2000301
synonyms:
- synonym_text: Physiology and metabolism.enzymes.[].activity
  synonym_type: RELATED_SYNONYM
  source: metpo.owl
domain: https://w3id.org/metpo/1000525
range_: https://w3id.org/metpo/1000527
evidence:
- reference: PMID:21413255
  snippet: activity
  notes: Microbial-physiology reference supports 'does not show activity of' as
    a canonical predicate relating an organism to an enzyme/activity class
    (asserted negatively), composed at assertion time.
curation_history:
- timestamp: '2026-05-05T01:35:46.991570+00:00'
  curator: seed_from_metpo
  action: SEEDED_FROM_METPO
  changes: imported from data/raw/metpo.owl (OBJECT_PROPERTY)
  llm_assisted: false
- timestamp: '2026-05-10T00:00:00-07:00'
  curator: codex
  action: DEPRECATED_PROPERTY_RECORD
  changes: Deprecated generic negative biochemical conversion or activity relation
    carrier; later replacement should use more specific trait records that combine
    the relation with the substrate, product, enzyme or activity target, assay context,
    growth condition, and negative evidence.
  llm_assisted: true
- timestamp: '2026-05-16T08:50:00-07:00'
  curator: claude
  action: UNDEPRECATED_AS_COMPOSITION_PRIMITIVE
  changes: 'Restored from DEPRECATED to REVIEWED under the predicate+class composition
    pattern (intended use: <organism> + this predicate + CHEBI chemical class). Added
    DOI/PMID-backed definition, evidence, and explicit domain/range slots.'
  llm_assisted: true