identifier: METPO:2000001
label: organism interacts with chemical
definition: The root OBJECT_PROPERTY for all organism-to-chemical interactions in
  the metabolism vocabulary; concrete uses (uses-as-X, ferments, produces, etc.) specialise
  this relation.
definition_source: DOI:10.1146/annurev.micro.55.1.485
trait_category: METABOLISM
term_kind: OBJECT_PROPERTY
mapping_status: REVIEWED
domain: https://w3id.org/metpo/1000525
range_: http://purl.obolibrary.org/obo/CHEBI_24431
evidence:
- reference: DOI:10.1146/annurev.micro.55.1.485
  snippet: interaction
  notes: Microbial-physiology reference supports 'organism interacts with chemical'
    as a canonical predicate composed with a CHEBI-class chemical object at assertion
    time.
curation_history:
- timestamp: '2026-05-05T01:35:46.950239+00:00'
  curator: seed_from_metpo
  action: SEEDED_FROM_METPO
  changes: imported from data/raw/metpo.owl (OBJECT_PROPERTY)
  llm_assisted: false
- timestamp: '2026-05-10T00:00:00-07:00'
  curator: codex
  action: DEPRECATED_PROPERTY_RECORD
  changes: Deprecated generic metabolism relation carrier; later replacement should
    use more specific trait records that combine the relation with the chemical, phenotype,
    quality, compartment, enzyme or activity target, growth context, measurement,
    or other entity.
  llm_assisted: true
- timestamp: '2026-05-16T08:50:00-07:00'
  curator: claude
  action: UNDEPRECATED_AS_COMPOSITION_PRIMITIVE
  changes: 'Restored from DEPRECATED to REVIEWED under the predicate+class composition
    pattern (intended use: <organism> + this predicate + CHEBI chemical class). Added
    DOI/PMID-backed definition, evidence, and explicit domain/range slots.'
  llm_assisted: true
- timestamp: '2026-05-17T10:00:00-07:00'
  curator: claude
  action: ADDED_EXTERNAL_PREDICATE_XREF
  changes: 'Added xrefs [''MICRO:0000975''] to record an external equivalence predicate.'
  llm_assisted: true
- timestamp: '2026-05-17T15:00:00-07:00'
  curator: claude
  action: REVERTED_NON_EQUIVALENT_XREF
  changes: 'Removed MICRO:0000975 xref per Copilot review of PR #56. This record
    is the root for ALL organism-to-chemical interactions (produces, uses-as-X,
    ferments, etc.), while MICRO:0000975 "uses chemical entity" is narrower (use
    relations only). Encoding it as an xrefs equivalence would mismap downstream
    consumers. No other ontology has a sufficiently broad organism-to-chemical
    root predicate, so xrefs left empty.'
  llm_assisted: true