identifier: METPO:1000886 label: cell length large definition: A cell-length phenotype in which the longer cell dimension exceeds approximately 3 micrometers. definition_source: DOI:10.1126/science.aaa1313 trait_category: MORPHOLOGY term_kind: CLASS mapping_status: REVIEWED parent_traits: - METPO:1000881 synonyms: - synonym_text: L_>3 synonym_type: RELATED_SYNONYM source: metpo.owl evidence: - reference: DOI:10.1126/science.aaa1313 snippet: cell size scales with growth rate notes: Growth-rate-dependent size law supports large cell length under fast-growth or division-delayed regimes. - reference: DOI:10.1038/nrmicro2671 snippet: directs cell division notes: FtsZ-divisome review supports division-site timing as a control point governing whether cells reach larger lengths before constriction. causal_graphs: - graph_id: cell_length_large_division_delay title: Large cell-length from fast growth or division delay description: DOI-backed graph linking fast elongation, delayed FtsZ-ring constriction, or filamentous growth programs to large cell length (>3 μm). nodes: - node_id: cell_length_large_trait label: cell length large node_type: TRAIT grounding: METPO:1000886 description: Cell length exceeding approximately 3 μm. - node_id: cell_length_trait label: cell length node_type: TRAIT grounding: METPO:1000881 description: Regulated longer cellular dimension. - node_id: fast_elongation label: fast elongation rate node_type: BIOLOGICAL_PROCESS description: Rapid axial elongation between divisions. - node_id: division_timing_delay label: division-timing delay node_type: BIOLOGICAL_PROCESS description: Postponement of FtsZ-ring constriction extending elongation. - node_id: sos_response label: SOS response node_type: BIOLOGICAL_PROCESS description: DNA-damage/stress-activated regulatory program that induces division inhibitors. grounding: GO:0009432 - node_id: sula_division_inhibition label: SulA-mediated division inhibition node_type: BIOLOGICAL_PROCESS description: Inhibition of cell division mediated by the SOS-induced inhibitor SulA. - node_id: sula_protein label: SulA node_type: GENE_OR_PROTEIN description: SOS-induced cell-division inhibitor protein that blocks FtsZ assembly. grounding: UniProtKB:H8YHZ0 - node_id: ftsz_zring label: FtsZ Z-ring node_type: BIOLOGICAL_PROCESS description: Assembly of the FtsZ ring at midcell that initiates cytokinesis. - node_id: ftsz_protein label: FtsZ node_type: GENE_OR_PROTEIN description: Bacterial tubulin homolog whose abundance is rate-limiting for division. grounding: UniProtKB:C0LUM8 - node_id: constriction_onset label: onset of constriction node_type: BIOLOGICAL_PROCESS description: Initiation of septal constriction during cytokinesis. edges: - subject: fast_elongation predicate: contributes to object: cell_length_large_trait description: Fast elongation between divisions yields longer cells. evidence: - reference: DOI:10.1126/science.aaa1313 snippet: cell size scales with growth rate notes: Supports fast growth as a producer of larger cell sizes. predicate_id: RO:0002326 - subject: division_timing_delay predicate: contributes to object: cell_length_large_trait description: Delaying division allows continued elongation past the typical size. evidence: - reference: DOI:10.1038/nrmicro2671 snippet: directs cell division notes: Supports division timing as a control point for cell length. predicate_id: RO:0002326 - subject: cell_length_large_trait predicate: is a object: cell_length_trait description: Large cell length is a quantitative bin of the cell-length phenotype. evidence: - reference: DOI:10.1016/j.cub.2014.07.022 snippet: cell size is tightly controlled notes: Supports large length as a value within the regulated cell-length distribution. predicate_id: rdfs:subClassOf - subject: sos_response predicate: induces object: sula_division_inhibition description: DNA damage/stress activates the SOS program, inducing division inhibitors that halt septation and promote elongation. evidence: - reference: DOI:10.1101/2025.05.13.653778 notes: SOS regulon upregulates sulA; SulA prevents Z-ring formation and halts division. - subject: sula_protein predicate: inhibits assembly of object: ftsz_zring description: SulA blocks FtsZ polymerization/assembly, delaying cytokinesis and allowing continued elongation. evidence: - reference: DOI:10.1101/2025.05.13.653778 notes: 'Canonical edge for many bacteria: SulA inhibits FtsZ assembly by sequestering monomers, directly blocking polymerization.' - subject: ftsz_protein predicate: delays object: constriction_onset description: FtsZ copy number is rate-limiting for division; reduced FtsZ delays septation and can increase cell length before division. evidence: - reference: DOI:10.1038/s41467-024-54242-w notes: FtsZ numbers are rate-limiting for cell division; ~20% downregulation may delay division. curation_history: - timestamp: '2026-05-05T01:35:46.920780+00:00' curator: seed_from_metpo action: SEEDED_FROM_METPO changes: imported from data/raw/metpo.owl (CLASS) llm_assisted: false - timestamp: '2026-05-11T22:30:00-07:00' curator: claude action: CURATED_CAUSAL_GRAPH changes: Added DOI-backed causal graph linking fast elongation and division-timing delay to large cell length (>3 μm). llm_assisted: true - timestamp: '2026-05-20T03:35:31Z' curator: claude action: GROUND_CAUSAL_PREDICATES changes: Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002326×2, rdfs:subClassOf×1). llm_assisted: true - timestamp: '2026-06-23T00:00:00Z' curator: claude action: ENRICH_CAUSAL_GRAPH changes: Added 3 evidence-backed generic edges (6 new nodes) from the deep-research report. llm_assisted: true - timestamp: '2026-06-24T17:21:19Z' curator: claude action: GROUND_CAUSAL_NODES changes: Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:C0LUM8×1). llm_assisted: true - timestamp: '2026-06-24T17:23:33Z' curator: claude action: GROUND_CAUSAL_NODES changes: Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0009432×1). llm_assisted: true - timestamp: '2026-06-26T07:15:19Z' curator: claude action: GROUND_CAUSAL_NODES changes: Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:H8YHZ0×1). llm_assisted: true