identifier: METPO:1000884 label: cell length small definition: A cell-length phenotype in which the longer cell dimension lies approximately between 1.3 and 2 micrometers. definition_source: DOI:10.1016/j.cell.2014.11.022 trait_category: MORPHOLOGY term_kind: CLASS mapping_status: REVIEWED parent_traits: - METPO:1000881 synonyms: - synonym_text: L_1.3_2 synonym_type: RELATED_SYNONYM source: metpo.owl evidence: - reference: DOI:10.1016/j.cell.2014.11.022 snippet: cells grow by a fixed amount between divisions notes: Adder-model paper supports a defined inter-divisional length increment that produces a narrow length distribution at standard growth conditions. causal_graphs: - graph_id: cell_length_small_size_setpoint title: Small cell-length size setpoint description: DOI-backed graph linking adder-controlled size homeostasis to a small cell-length range (1.3–2 μm). nodes: - node_id: cell_length_small_trait label: cell length small node_type: TRAIT grounding: METPO:1000884 description: Cell length approximately 1.3–2 μm. - node_id: cell_length_trait label: cell length node_type: TRAIT grounding: METPO:1000881 description: Regulated longer cellular dimension. - node_id: adder_principle label: adder size control node_type: BIOLOGICAL_PROCESS description: Fixed inter-division length increment underlying size homeostasis. - node_id: standard_growth_conditions label: standard growth conditions node_type: ENVIRONMENTAL_FACTOR description: Routine laboratory growth conditions producing typical bacterial cell sizes. - node_id: ftsz_abundance label: FtsZ abundance node_type: GENE_OR_PROTEIN description: Cellular level of the tubulin-like division protein FtsZ. - node_id: division_timing label: cell division timing node_type: BIOLOGICAL_PROCESS description: Timing/onset of septal constriction and cell division. - node_id: ftsz_ring_formation label: FtsZ ring formation node_type: BIOLOGICAL_PROCESS description: Assembly of the cytokinetic Z ring at the division site. - node_id: ftsn label: FtsN node_type: GENE_OR_PROTEIN description: Divisome protein that allosterically activates septal PG synthesis. grounding: UniProtKB:A3RWZ4 - node_id: ftswi_complex label: FtsWI septal PG synthase complex node_type: GENE_OR_PROTEIN description: FtsWI (within FtsQLBWI) septal peptidoglycan synthase complex. - node_id: septal_pg_synthesis label: septal peptidoglycan synthesis node_type: BIOLOGICAL_PROCESS description: Synthesis of septal peptidoglycan during cytokinesis. - node_id: zring_condensation label: Z-ring condensation and stability node_type: BIOLOGICAL_PROCESS description: Condensation and stabilization of the FtsZ ring. - node_id: ftsz_protoring label: FtsZ proto-ring (with FtsA/ZipA) node_type: GENE_OR_PROTEIN description: FtsZ proto-ring tethered by FtsA/ZipA initiating divisome assembly. - node_id: divisome_assembly label: divisome assembly node_type: BIOLOGICAL_PROCESS description: Assembly of the division machinery and septal synthesis. - node_id: min_nucleoid_occlusion label: Min system and nucleoid occlusion node_type: BIOLOGICAL_PROCESS description: Spatial regulators positioning FtsZ at midcell. - node_id: ftsz_midcell_positioning label: FtsZ positioning at midcell node_type: BIOLOGICAL_PROCESS description: Correct placement of FtsZ at the cell midpoint for symmetric division. edges: - subject: standard_growth_conditions predicate: enables object: adder_principle description: Standard nutrient/temperature regimes maintain adder size control. evidence: - reference: DOI:10.1016/j.cell.2014.11.022 snippet: cells grow by a fixed amount between divisions notes: Supports adder control under typical growth regimes. predicate_id: RO:0002327 - subject: adder_principle predicate: produces object: cell_length_small_trait description: Adder homeostasis under standard conditions yields a narrow length distribution in the small range. evidence: - reference: DOI:10.1016/j.cell.2014.11.022 snippet: cells grow by a fixed amount between divisions notes: Supports small length as a typical adder-controlled outcome. predicate_id: METPO:2000202 - subject: cell_length_small_trait predicate: is a object: cell_length_trait description: Small cell length is a quantitative bin of the cell-length phenotype. evidence: - reference: DOI:10.1016/j.cub.2014.07.022 snippet: cell size is tightly controlled notes: Supports small length as a value within the regulated cell-length distribution. predicate_id: rdfs:subClassOf - subject: ftsz_abundance predicate: rate_limiting_for object: division_timing description: FtsZ levels are a rate-limiting factor for division timing; higher FtsZ promotes earlier division. evidence: - reference: DOI:10.1038/s41467-024-54242-w notes: FtsZ numbers are identified as one of the rate-limiting factors for cell divisions. - subject: ftsz_ring_formation predicate: modulates object: cell_length_trait description: Delayed FtsZ ring formation delays division until the cell reaches a larger size, increasing cell length. evidence: - reference: DOI:10.1038/s41467-023-41487-0 notes: Delay cell division until the cell reaches a larger size. predicate_id: RO:0002211 - subject: ftsn predicate: activates object: ftswi_complex description: FtsN allosterically activates the FtsWI septal PG synthase complex. evidence: - reference: DOI:10.1038/s41467-024-52217-5 notes: Activation of the sPG synthase (FtsWI within the FtsQLBWI complex) depends on FtsN. predicate_id: RO:0002213 - subject: septal_pg_synthesis predicate: promotes object: zring_condensation description: Septal peptidoglycan synthesis feeds back to promote Z-ring condensation and stability. evidence: - reference: DOI:10.1038/s41467-024-52217-5 notes: Septal cell wall synthesis feeds back to promote Z ring condensation and stability. predicate_id: RO:0002213 - subject: ftsz_protoring predicate: organizes object: divisome_assembly description: The FtsZ proto-ring with FtsA/ZipA organizes divisome assembly and is required for localization of other divisome proteins. evidence: - reference: DOI:10.1038/s41579-023-00942-x notes: FtsZ is required for localization of all other divisome proteins. - subject: min_nucleoid_occlusion predicate: positions object: ftsz_midcell_positioning description: Min system and nucleoid occlusion position FtsZ at midcell for proper division-site placement. evidence: - reference: DOI:10.1038/s42003-024-07279-y notes: For positioning FtsZ at mid cell division sites. curation_history: - timestamp: '2026-05-05T01:35:46.919890+00:00' curator: seed_from_metpo action: SEEDED_FROM_METPO changes: imported from data/raw/metpo.owl (CLASS) llm_assisted: false - timestamp: '2026-05-11T22:30:00-07:00' curator: claude action: CURATED_CAUSAL_GRAPH changes: Added DOI-backed causal graph linking adder size control under standard growth conditions to small cell length (1.3–2 μm). llm_assisted: true - timestamp: '2026-05-20T03:35:31Z' curator: claude action: GROUND_CAUSAL_PREDICATES changes: Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, rdfs:subClassOf×1). llm_assisted: true - timestamp: '2026-05-24T04:13:19Z' curator: claude action: RENAME_PREDICATE_LABELS changes: 'Renamed 1 causal-edge predicate label(s) to align with existing groundings: supports → enables ×1.' llm_assisted: true - timestamp: '2026-05-24T04:13:21Z' curator: claude action: GROUND_CAUSAL_PREDICATES changes: Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002327×1). llm_assisted: true - timestamp: '2026-06-23T00:00:00Z' curator: claude action: ENRICH_CAUSAL_GRAPH changes: Added 6 evidence-backed generic edges (11 new nodes) from the deep-research report. llm_assisted: true - timestamp: '2026-06-24T17:21:13Z' curator: claude action: GROUND_CAUSAL_PREDICATES changes: Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002213×2, RO:0002211×1). llm_assisted: true - timestamp: '2026-06-26T07:15:19Z' curator: claude action: GROUND_CAUSAL_NODES changes: Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A3RWZ4×1). llm_assisted: true