identifier: METPO:1000677
label: ovoid shaped
definition: A cell shape in which an organism has an oval morphology, rounded at both
  ends with one end often slightly broader than the other.
definition_source: DOI:10.1016/j.cub.2021.04.041
trait_category: MORPHOLOGY
term_kind: CLASS
mapping_status: REVIEWED
parent_traits:
- METPO:1000666
synonyms:
- synonym_text: S_ovoid
  synonym_type: RELATED_SYNONYM
  source: metpo.owl
- synonym_text: ovoid-shaped
  synonym_type: RELATED_SYNONYM
  source: metpo.owl
created_by: Luke Wang
evidence:
- reference: DOI:10.1016/j.cub.2021.04.041
  snippet: ovoid bacterium Streptococcus pneumoniae
  notes: Supports ovoid bacterial morphology as a recognized ovococcal shape.
causal_graphs:
- graph_id: ovoid_shaped_midcell_pg_assembly
  title: Ovoid-shape midcell peptidoglycan mechanism
  description: Evidence-backed causal sketch linking ovoid morphology to midcell peptidoglycan
    assembly, MapZ division-site placement, DivIVA-associated growth, and rounded
    ovoid geometry.
  nodes:
  - node_id: ovoid_shaped_trait
    label: ovoid shaped
    node_type: TRAIT
    grounding: METPO:1000677
    description: Rounded ovoid bacterial morphology.
  - node_id: midcell_pg_assembly
    label: midcell peptidoglycan assembly
    node_type: BIOLOGICAL_PROCESS
    description: Wall synthesis and assembly in an annular midcell region.
  - node_id: mapZ
    label: MapZ
    node_type: GENE_OR_PROTEIN
    description: Membrane protein involved in division-site placement in S. pneumoniae.
  - node_id: divIVA
    label: DivIVA
    node_type: GENE_OR_PROTEIN
    description: Protein involved in septum splitting and elongation in ovococci.
    grounding: UniProtKB:Q1IYG2
  - node_id: septum_splitting
    label: septum splitting
    node_type: BIOLOGICAL_PROCESS
    description: Separation and remodeling of the division septum.
  - node_id: ovoid_geometry
    label: ovoid geometry
    node_type: BIOLOGICAL_PROCESS
    description: Rounded, egg-like cell-body geometry.
  - node_id: septal_pg_synthesis
    label: septal peptidoglycan synthesis
    node_type: BIOLOGICAL_PROCESS
    description: Mode of PG synthesis building the division septum in ovococci.
  - node_id: peripheral_pg_synthesis
    label: peripheral peptidoglycan synthesis
    node_type: BIOLOGICAL_PROCESS
    description: Mode of PG synthesis elongating the cell wall, producing ovoid aspect
      ratio.
  - node_id: ftsz_treadmilling
    label: FtsZ treadmilling
    node_type: BIOLOGICAL_PROCESS
    description: Treadmilling dynamics of the FtsZ cytoskeletal ring guiding septal
      synthesis.
  - node_id: ftsw_pbp2x
    label: FtsW-PBP2x complex
    node_type: GENE_OR_PROTEIN
    description: Divisome PG synthase complex that builds the division septum.
  - node_id: roda_pbp2b
    label: RodA-PBP2b elongasome
    node_type: GENE_OR_PROTEIN
    description: Elongasome PG synthase pair driving peripheral wall elongation.
  - node_id: ftsz_ring
    label: FtsZ ring
    node_type: CELLULAR_LOCALIZATION
    description: The Z-ring division apparatus positioned at midcell.
  - node_id: concentric_midcell_rings
    label: concentric midcell rings
    node_type: CELLULAR_LOCALIZATION
    description: Organization of septal and peripheral PG machineries into concentric
      midcell rings.
  edges:
  - subject: mapZ
    predicate: positions
    object: midcell_pg_assembly
    description: MapZ participates in division-site placement for ovoid growth.
    evidence:
    - reference: DOI:10.1016/j.mib.2016.07.014
      snippet: relies on the membrane protein MapZ
      notes: Supports MapZ as a division-positioning factor in S. pneumoniae.
  - subject: midcell_pg_assembly
    predicate: causes
    object: ovoid_geometry
    description: Midcell peptidoglycan assembly shapes ovoid cell geometry.
    evidence:
    - reference: DOI:10.1016/j.cub.2021.04.041
      snippet: peptidoglycan synthesis ... in the ovoid bacterium
      notes: Supports PG assembly dynamics in ovoid S. pneumoniae.
    predicate_id: biolink:causes
  - subject: divIVA
    predicate: controls
    object: septum_splitting
    description: DivIVA controls septum splitting and elongation dynamics.
    evidence:
    - reference: DOI:10.1128/mbio.01311-24
      snippet: DivIVA controls the dynamics of septum splitting and cell elongation
      notes: Supports DivIVA in ovococcal cell morphogenesis.
    predicate_id: RO:0002211
  - subject: septum_splitting
    predicate: contributes to
    object: ovoid_geometry
    description: Septum splitting and elongation dynamics contribute to ovoid morphology.
    evidence:
    - reference: DOI:10.1128/mbio.01311-24
      snippet: how ovoid bacteria proliferate
      notes: Supports septum/elongation dynamics as relevant to ovoid bacterial proliferation.
    predicate_id: RO:0002326
  - subject: ovoid_geometry
    predicate: manifests as
    object: ovoid_shaped_trait
    description: Ovoid cell-body geometry manifests the ovoid-shaped trait.
    evidence:
    - reference: DOI:10.1016/j.cub.2021.04.041
      snippet: ovoid-shaped bacteria
      notes: Supports the trait endpoint.
    predicate_id: METPO:2007400
  - subject: midcell_pg_assembly
    predicate: has component
    object: septal_pg_synthesis
    description: Ovococcal midcell growth includes a distinct septal PG synthesis
      mode.
    evidence:
    - reference: DOI:10.1042/BSR20221664
      notes: 'There are two spatially distinct modes of PG synthesis: septal and peripheral.'
  - subject: midcell_pg_assembly
    predicate: has component
    object: peripheral_pg_synthesis
    description: Ovococcal midcell growth includes a distinct peripheral PG synthesis
      mode.
    evidence:
    - reference: DOI:10.1042/BSR20221664
      notes: 'There are two spatially distinct modes of PG synthesis: septal and peripheral.'
  - subject: ftsz_treadmilling
    predicate: drives
    object: septal_pg_synthesis
    description: FtsZ treadmilling drives septal PG synthesis.
    evidence:
    - reference: DOI:10.1042/BSR20221664
      notes: FtsZ treadmilling drives septal PG synthesis together with the FtsW-PBP2x
        complex.
  - subject: ftsw_pbp2x
    predicate: synthesizes
    object: septal_pg_synthesis
    description: The FtsW-PBP2x complex synthesizes the division septum.
    evidence:
    - reference: DOI:10.1042/BSR20221664
      notes: Septal PG synthesis is driven by the FtsW-PBP2x complex to synthesize
        the division septum.
  - subject: roda_pbp2b
    predicate: drives
    object: peripheral_pg_synthesis
    description: The RodA-PBP2b elongasome drives peripheral PG synthesis.
    evidence:
    - reference: DOI:10.1042/BSR20221664
      notes: Peripheral (elongation) activity is carried out by the elongasome, driven
        by the RodA-PBP2b pair.
  - subject: mapZ
    predicate: positions
    object: ftsz_ring
    description: MapZ guides movement and positioning of the FtsZ ring.
    evidence:
    - reference: DOI:10.1042/BSR20221664
      notes: MapZ guides movement of FtsZ and associated proteins from the septal
        ring to the equatorial ring.
  - subject: midcell_pg_assembly
    predicate: assembles as
    object: concentric_midcell_rings
    description: Septal and peripheral PG machineries assemble at midcell into concentric
      rings.
    evidence:
    - reference: DOI:10.1042/BSR20221664
      notes: Septal and peripheral PG-synthesis machineries assemble at mid-cell into
        concentric rings (inner septal, outer peripheral).
curation_history:
- timestamp: '2026-05-05T01:35:46.891106+00:00'
  curator: seed_from_metpo
  action: SEEDED_FROM_METPO
  changes: imported from data/raw/metpo.owl (CLASS)
  llm_assisted: false
- timestamp: '2026-05-11T20:05:00-07:00'
  curator: codex
  action: CURATED_WITH_LITERATURE
  changes: Added DOI-backed definition and causal graph for MapZ, DivIVA, midcell
    peptidoglycan assembly, septum splitting, and ovoid cell geometry.
  llm_assisted: true
- timestamp: '2026-05-20T03:35:31Z'
  curator: claude
  action: GROUND_CAUSAL_PREDICATES
  changes: Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv
    (RO:0002326×1).
  llm_assisted: true
- timestamp: '2026-05-23T21:30:07Z'
  curator: claude
  action: GROUND_CAUSAL_PREDICATES
  changes: Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv
    (RO:0002211×1, METPO:2007400×1).
  llm_assisted: true
- timestamp: '2026-05-24T04:13:19Z'
  curator: claude
  action: RENAME_PREDICATE_LABELS
  changes: 'Renamed 1 causal-edge predicate label(s) to align with existing groundings:
    shapes → causes ×1.'
  llm_assisted: true
- timestamp: '2026-05-24T04:13:22Z'
  curator: claude
  action: GROUND_CAUSAL_PREDICATES
  changes: Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv
    (biolink:causes×1).
  llm_assisted: true
- timestamp: '2026-05-24T05:05:15Z'
  curator: claude
  action: GROUND_CAUSAL_NODES
  changes: Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv
    (UniProtKB:Q1IYG2×1).
  llm_assisted: true
- timestamp: '2026-06-23T00:00:00Z'
  curator: claude
  action: ENRICH_CAUSAL_GRAPH
  changes: Added 7 evidence-backed generic edges (7 new nodes) from the deep-research
    report.
  llm_assisted: true