identifier: METPO:1000686 label: vibrio shaped definition: A cell shape in which an organism has a curved rod or comma morphology, characterized by a short curved cylindrical form with a single arc. definition_source: DOI:10.1016/j.cell.2016.12.019 trait_category: MORPHOLOGY term_kind: CLASS mapping_status: REVIEWED parent_traits: - METPO:1000666 synonyms: - synonym_text: vibrio synonym_type: RELATED_SYNONYM source: metpo.owl - synonym_text: vibrio-shaped synonym_type: RELATED_SYNONYM source: metpo.owl created_by: Jed Dongjin Kim-Ozaeta evidence: - reference: DOI:10.1016/j.cell.2016.12.019 snippet: V. cholerae has a characteristic curved rod morphology notes: Supports vibrio/comma morphology and a source-backed curvature mechanism in Vibrio cholerae. canonical_examples: - taxon_id: NCBITaxon:666 taxon_label: Vibrio cholerae note: "Comma-shaped (curved-rod) vibrio; cholera agent and the canonical Vibrio." reference: PMID:28086090 causal_graphs: - graph_id: vibrio_shaped_crvA_curvature title: Vibrio-shape CrvA curvature mechanism description: Evidence-backed causal sketch linking vibrioid curved-rod morphology to periplasmic CrvA polymers and asymmetric peptidoglycan insertion. nodes: - node_id: vibrio_shaped_trait label: vibrio shaped node_type: TRAIT grounding: METPO:1000686 description: Short curved-rod or comma-shaped bacterial morphology. - node_id: crvA label: CrvA node_type: GENE_OR_PROTEIN description: Periplasmic polymer-forming curvature determinant in Vibrio. - node_id: periplasmic_filament label: periplasmic filament node_type: CELLULAR_LOCALIZATION description: CrvA polymer structure at the inner curved face of the cell. - node_id: asymmetric_peptidoglycan_insertion label: asymmetric peptidoglycan insertion node_type: BIOLOGICAL_PROCESS description: Unequal cell-wall insertion across inner and outer faces. - node_id: cell_body_curvature label: cell-body curvature node_type: BIOLOGICAL_PROCESS description: Curving of an otherwise rod-like cell body. - node_id: crvB label: CrvB node_type: GENE_OR_PROTEIN description: Periplasmic curvature determinant that co-assembles with CrvA into the inner-curve filament. - node_id: vadR_srna label: VadR sRNA node_type: GENE_OR_PROTEIN description: Small RNA that post-transcriptionally represses crvA mRNA to limit curvature. - node_id: crvA_mrna label: crvA mRNA node_type: GENE_OR_PROTEIN description: Messenger RNA encoding the CrvA curvature determinant. - node_id: vxrAB_tcs label: VxrAB two-component system node_type: GENE_OR_PROTEIN description: Two-component signaling system that activates vadR transcription. - node_id: cyclic_di_gmp label: cyclic di-GMP node_type: CHEMICAL description: Second messenger that, when elevated, decreases cell curvature to generate straight rods. grounding: CHEBI:49537 edges: - subject: crvA predicate: self-assembles into object: periplasmic_filament description: CrvA forms periplasmic filaments at the inner face of cell curvature. evidence: - reference: DOI:10.1016/j.cell.2016.12.019 snippet: CrvA self-assembles into filaments at the inner face notes: Supports CrvA as a periplasmic polymer at the inner curvature. - subject: periplasmic_filament predicate: patterns object: asymmetric_peptidoglycan_insertion description: CrvA filaments pattern differential peptidoglycan insertion. evidence: - reference: DOI:10.1016/j.cell.2016.12.019 snippet: asymmetrically patterns peptidoglycan insertion notes: Supports CrvA-dependent spatial patterning of wall insertion. - subject: asymmetric_peptidoglycan_insertion predicate: causes object: cell_body_curvature description: Unequal peptidoglycan insertion creates more material on the outer face than the inner face, curving the cell. evidence: - reference: DOI:10.1016/j.cell.2016.12.019 snippet: causing more material insertions into the outer face notes: Supports asymmetric wall insertion as the proximal cause of curvature. predicate_id: biolink:causes - subject: cell_body_curvature predicate: produces object: vibrio_shaped_trait description: Curved rod morphology produces the vibrioid/comma-shaped trait. evidence: - reference: DOI:10.1016/j.cell.2016.12.019 snippet: characteristic curved rod morphology notes: Supports the observed Vibrio morphology as a curved-rod shape. predicate_id: METPO:2000202 - subject: crvB predicate: increases object: cell_body_curvature description: CrvB expression increases CrvA assembly and cell curvature in a dose-dependent manner. evidence: - reference: DOI:10.1101/2020.02.20.954503 notes: crvB expression increased CrvA-GFP assembly as well as cell curvature in a dose-dependent manner. predicate_id: RO:0002213 - subject: crvB predicate: colocalizes with object: periplasmic_filament description: CrvB colocalizes with CrvA in the same periplasmic inner-curve filament structure. evidence: - reference: DOI:10.1101/2020.02.20.954503 notes: Both proteins localized to the same structure; CrvB-GFP filaments colocalized with periplasmic DsbA-mCherry. - subject: vadR_srna predicate: represses object: crvA_mrna description: VadR sRNA is a post-transcriptional inhibitor of crvA mRNA. evidence: - reference: DOI:10.1038/s41467-020-19890-8 notes: The VadR small RNA acts as a post-transcriptional inhibitor of the crvA mRNA. - subject: crvA_mrna predicate: translated into object: crvA description: crvA mRNA is translated into the CrvA curvature determinant protein. evidence: - reference: DOI:10.1038/s41467-020-19890-8 notes: crvA mRNA encodes the periplasmic CrvA protein that determines cell curvature. - subject: vadR_srna predicate: decreases object: cell_body_curvature description: Mutation of vadR increases cell curvature whereas overexpression has the inverse effect, indicating VadR limits curvature. evidence: - reference: DOI:10.1038/s41467-020-19890-8 notes: Mutation of vadR increases cell curvature, whereas overexpression has the inverse effect. predicate_id: RO:0002212 - subject: vxrAB_tcs predicate: activates transcription of object: vadR_srna description: The VxrAB two-component system activates vadR transcription. evidence: - reference: DOI:10.1038/s41467-020-19890-8 notes: vadR transcription is activated by the VxrAB two-component system. - subject: cyclic_di_gmp predicate: decreases object: cell_body_curvature description: High c-di-GMP concentrations decrease cell curvature to generate straight rods. evidence: - reference: DOI:10.1073/pnas.2010199117 notes: High c-di-GMP concentrations decrease cell curvature to generate straight rods. predicate_id: RO:0002212 curation_history: - timestamp: '2026-05-05T01:35:46.896189+00:00' curator: seed_from_metpo action: SEEDED_FROM_METPO changes: imported from data/raw/metpo.owl (CLASS) llm_assisted: false - timestamp: '2026-05-11T18:00:00-07:00' curator: codex action: CURATED_WITH_LITERATURE changes: Reviewed vibrio shape and added DOI-backed causal graph for CrvA periplasmic filaments, asymmetric peptidoglycan insertion, and curved-rod morphology. llm_assisted: true - timestamp: '2026-05-20T03:35:31Z' curator: claude action: GROUND_CAUSAL_PREDICATES changes: Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1). llm_assisted: true - timestamp: '2026-05-20T05:49:25Z' curator: claude action: GROUND_CAUSAL_PREDICATES changes: Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:causes×1). llm_assisted: true - timestamp: '2026-06-23T00:00:00Z' curator: claude action: ENRICH_CAUSAL_GRAPH changes: Added 7 evidence-backed generic edges (5 new nodes) from the deep-research report. llm_assisted: true - timestamp: '2026-06-24T17:21:14Z' curator: claude action: GROUND_CAUSAL_PREDICATES changes: Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002212×2, RO:0002213×1). llm_assisted: true - timestamp: '2026-06-24T17:23:34Z' curator: claude action: GROUND_CAUSAL_NODES changes: Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:49537×1). llm_assisted: true