identifier: METPO:1007091
label: coagulase negative
definition: Test-outcome phenotype where the coagulase test yields a negative result.
  The underlying enzyme-organism relation should additionally be asserted via <organism>
  METPO:2000303 'does not show activity of' <coagulase enzyme term> once a sufficiently
  specific enzyme term is selected.
trait_category: OTHER
term_kind: CLASS
mapping_status: SEEDED
parent_traits:
- METPO:1007089
synonyms:
- synonym_text: coagulase -
  synonym_type: EXACT_SYNONYM
  source: metpo.owl
- synonym_text: coagulase test negative
  synonym_type: EXACT_SYNONYM
  source: metpo.owl
created_by: Marcin Joachimiak
curation_history:
- timestamp: '2026-09-11T09:54:43Z'
  curator: seed_from_metpo
  action: SEEDED_FROM_METPO
  changes: imported from data/raw/metpo.owl (CLASS)
- timestamp: '2026-09-11T09:59:00Z'
  curator: codex
  action: ENRICHED_FROM_LITERATURE
  changes: Enriched the seeded METPO coagulase negative test-outcome phenotype with
    DOI- and NCBI-backed evidence after a repository-wide duplicate review covering
    ignored and hidden files.
  llm_assisted: true
definition_source: DOI:10.3390/microorganisms9040830
evidence:
- reference: DOI:10.3390/microorganisms9040830
  snippet: Coagulase-negative staphylococci (CoNS) form a large group of Gram-positive
    cocci united by their mutual lack of the virulence factor coagulase
  notes: Michels et al. define coagulase-negative staphylococci by absence of the
    coagulase virulence factor, supporting the negative assay-outcome phenotype.
- reference: https://www.ncbi.nlm.nih.gov/books/NBK563240/
  snippet: Staphylococcus epidermidis is a coagulase-negative, gram-positive cocci
    bacteria that form clusters
  notes: Lee and Anjum identify S. epidermidis as coagulase-negative, providing a
    stable species-level example of a negative coagulase test outcome.
canonical_examples:
- taxon_id: NCBITaxon:1282
  taxon_label: Staphylococcus epidermidis
  note: Lee and Anjum describe S. epidermidis as a coagulase-negative Staphylococcus
    species.
  reference: https://www.ncbi.nlm.nih.gov/books/NBK563240/