identifier: METPO:1007090
label: coagulase positive
definition: Test-outcome phenotype where the coagulase test yields a positive result
  (plasma clotting). The underlying enzyme-organism relation should additionally be
  asserted via <organism> METPO:2000302 'shows activity of' <coagulase enzyme term>
  once a sufficiently specific enzyme term is selected (no GO/EC term currently exists
  at the bacteriological coagulase test granularity).
trait_category: OTHER
term_kind: CLASS
mapping_status: SEEDED
parent_traits:
- METPO:1007089
synonyms:
- synonym_text: coagulase +
  synonym_type: EXACT_SYNONYM
  source: metpo.owl
- synonym_text: coagulase test positive
  synonym_type: EXACT_SYNONYM
  source: metpo.owl
created_by: Marcin Joachimiak
curation_history:
- timestamp: '2026-09-11T09:35:28Z'
  curator: seed_from_metpo
  action: SEEDED_FROM_METPO
  changes: imported from data/raw/metpo.owl (CLASS)
- timestamp: '2026-09-11T09:37:00Z'
  curator: codex
  action: ENRICHED_FROM_LITERATURE
  changes: Enriched the seeded METPO coagulase positive test-outcome phenotype with
    DOI-backed plasma-clotting evidence after a repository-wide duplicate review covering
    ignored and hidden files.
  llm_assisted: true
definition_source: DOI:10.1099/mic.0.000019
evidence:
- reference: DOI:10.1099/mic.0.000019
  snippet: coagulase-positive S. aureus bacteria promoted clotting of plasma which
    was not seen when a coagulase-deficient mutant strain was used
  notes: Loof et al. show that coagulase-positive S. aureus clots plasma in a way
    lost from a coagulase-deficient mutant, directly supporting the positive test-outcome
    phenotype.
- reference: DOI:10.1371/journal.ppat.1001036
  snippet: Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase
    (Coa), a polypeptide that binds to and activates prothrombin
  notes: Cheng et al. connect S. aureus Coa secretion to prothrombin activation, the
    clotting activity detected by the coagulase test.
canonical_examples:
- taxon_id: NCBITaxon:1280
  taxon_label: Staphylococcus aureus
  note: Loof et al. use coagulase-positive S. aureus as a direct plasma-clotting example
    and contrast it with a coagulase-deficient mutant.
  reference: DOI:10.1099/mic.0.000019