identifier: traitmech:000167
label: arginine arylamidase activity
definition: A physiological enzyme-activity phenotype in which a cell exhibits arginine
  arylamidase/arginyl aminopeptidase activity, releasing N-terminal arginine or lysine
  residues from peptides or hydrolyzing arginine and lysine arylamides.
definition_source: https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
trait_category: PHYSIOLOGY
term_kind: CLASS
mapping_status: PROPOSED
parent_traits:
- METPO:1000059
synonyms:
- synonym_text: L-arginine arylamidase
  synonym_type: RELATED_SYNONYM
  source: DOI:10.3389/fgene.2023.1240581
- synonym_text: aminopeptidase B
  synonym_type: RELATED_SYNONYM
  source: https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
- synonym_text: arginine aminopeptidase
  synonym_type: RELATED_SYNONYM
  source: https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
- synonym_text: arginyl aminopeptidase
  synonym_type: RELATED_SYNONYM
  source: https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
- synonym_text: L-arginine aminopeptidase
  synonym_type: RELATED_SYNONYM
  source: https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
evidence:
- reference: https://iubmb.qmul.ac.uk/enzyme/EC3/4/11/6.html
  snippet: <b>Reaction:</b> Release of N-terminal Arg and Lys from oligopeptides when
    P1' is not Pro. Also acts on arylamides of Arg and Lys
  notes: The NC-IUBMB EC 3.4.11.6 entry accepts aminopeptidase B, records arginine
    aminopeptidase, arginyl aminopeptidase, and L-arginine aminopeptidase as other
    names, and includes arginine and lysine arylamides in the reaction scope.
- reference: DOI:10.3389/fgene.2023.1240581
  snippet: Both of these strains exhibit positive results for oxidase, gamma-glutamyl
    transferase, alkaline phosphatase, pyrrolidonyl arylamidase, L-arginine arylamidase,
    and L-aspartate arylamidase
  notes: Wang et al. reported both Helicobacter zhangjianzhongii isolates as positive
    for L-arginine arylamidase in the formal species description.
- reference: DOI:10.1099/ijsem.0.006017
  snippet: arginine arylamidase, proline arylamidase, leucyl glycine arylamidase,
    phenylalanine arylamidase, leucine arylamidase, tyrosine arylamidase, alanine
    arylamidase, glycine arylamidase, histidine arylamidase
  notes: Srinivasan et al. listed arginine arylamidase among enzymatic activities
    present in the Amygdalobacter indicium species description, supporting the API
    arylamidase row as a directly assayed bacterial enzyme-activity phenotype.
canonical_examples:
- taxon_id: NCBITaxon:2974574
  taxon_label: Helicobacter zhangjianzhongii
  note: Wang et al. reported both Helicobacter zhangjianzhongii isolates as positive
    for L-arginine arylamidase in the formal species description.
  reference: DOI:10.3389/fgene.2023.1240581
discussions:
- discussion_id: arginine-arylamidase-activity-xref-gap
  prompt: Resolve an exact external ontology class for arginine arylamidase activity
    before adding a TraitRecord xref.
  kind: CURATION_TODO
  status: OPEN
  rationale: GO:0004177 denotes broad aminopeptidase molecular function, and EC 3.4.11.6
    denotes the aminopeptidase B/arginyl aminopeptidase molecular function rather
    than the organism-level arginine arylamidase assay phenotype. Both remain causal-node
    grounding leads rather than equivalent TraitRecord xrefs.
  posed_by: codex
  posed_date: '2026-09-12'
curation_history:
- timestamp: '2026-09-12T11:40:11Z'
  curator: codex
  action: MINTED_TRAITMECH_ID
  changes: Minted arginine arylamidase activity as a URL/DOI-backed TraitRecord after
    a repository-wide duplicate review covering ignored and hidden files; METPO has
    no exact arginine arylamidase activity class yet and the placeholder is reserved
    in proposals/metpo_traitmech_v44.
  llm_assisted: true