identifier: traitmech:000137
label: caseinase activity
definition: A physiological enzyme-activity phenotype in which a cell produces active
  caseinase proteases that hydrolyze casein.
definition_source: DOI:10.3389/fmicb.2018.01148
trait_category: PHYSIOLOGY
term_kind: CLASS
mapping_status: PROPOSED
parent_traits:
- METPO:1000059
synonyms:
- synonym_text: caseinase production
  synonym_type: RELATED_SYNONYM
  source: DOI:10.2174/1874285801408010025
evidence:
- reference: DOI:10.3389/fmicb.2018.01148
  snippet: two enzymes secreted by a B. cereus RC6 strain that permits the degradation
    of casein
  notes: Ouertani et al. identify secreted Bacillus cereus RC6 proteases that degrade
    casein in a dairy-product context.
- reference: DOI:10.2174/1874285801408010025
  snippet: screened for enzyme production (caseinase, gelatinase, amylase, carboxymethyl
    cellulase, and esterase)
  notes: Alves et al. use caseinase as a reusable extracellular hydrolytic-enzyme
    phenotype while screening environmental microbial isolates.
canonical_examples:
- taxon_id: NCBITaxon:1396
  taxon_label: Bacillus cereus
  note: Bacillus cereus RC6 secreted casein-degrading proteases in milk-matrix experiments.
  reference: DOI:10.3389/fmicb.2018.01148
discussions:
- discussion_id: caseinase-activity-xref-gap
  prompt: Resolve an exact external ontology class for caseinase activity before adding
    a TraitRecord xref.
  kind: CURATION_TODO
  status: OPEN
  rationale: GO:0008233 is a generic peptidase-activity class and is too broad for
    caseinase activity as an equivalent TraitRecord xref.
  posed_by: codex
  posed_date: '2026-09-11'
curation_history:
- timestamp: '2026-09-11T00:00:00Z'
  curator: codex
  action: MINTED_TRAITMECH_ID
  changes: Minted caseinase activity as a DOI-backed TraitRecord after a repository-wide
    duplicate review covering ignored and hidden files; METPO has no exact caseinase
    activity class yet.
  llm_assisted: true