identifier: traitmech:000136
label: gelatinase activity
definition: A physiological enzyme-activity phenotype in which a cell produces active
  gelatinase protease.
definition_source: DOI:10.1128/JB.01311-07
trait_category: PHYSIOLOGY
term_kind: CLASS
mapping_status: PROPOSED
parent_traits:
- METPO:1000059
synonyms:
- synonym_text: gelatinase-positive
  synonym_type: RELATED_SYNONYM
  source: DOI:10.1128/IAI.73.3.1606-1612.2005
- synonym_text: gelatinase production
  synonym_type: RELATED_SYNONYM
  source: DOI:10.1128/IAI.73.3.1606-1612.2005
evidence:
- reference: DOI:10.1128/JB.01311-07
  snippet: One of the well-studied virulence factors of Enterococcus faecalis is a
    secreted bacterial protease, termed gelatinase
  notes: Del Papa et al. identify Enterococcus faecalis gelatinase as a secreted bacterial
    protease and experimentally test maturation steps needed for full protease activity.
- reference: DOI:10.1128/IAI.73.3.1606-1612.2005
  snippet: all gelatinase-positive isolates but little to no translocation for gelatinase
    nonproducers
  notes: Zeng, Teng and Murray score Enterococcus faecalis isolates by gelatinase
    production and distinguish gelatinase-positive from gelatinase-negative phenotypes.
canonical_examples:
- taxon_id: NCBITaxon:1351
  taxon_label: Enterococcus faecalis
  note: Model gelatinase-producing bacterium used in gelE and fsr studies.
  reference: DOI:10.1128/JB.01311-07
discussions:
- discussion_id: gelatinase-activity-xref-gap
  prompt: Resolve an exact external ontology class for gelatinase activity before
    adding a TraitRecord xref.
  kind: CURATION_TODO
  status: OPEN
  rationale: GO:0008233 is the generic peptidase-activity class and MICRO:0000649
    denotes a gelatinase assay, so both are too broad or assay-level for equivalent
    TraitRecord xrefs.
  posed_by: codex
  posed_date: '2026-09-11'
curation_history:
- timestamp: '2026-09-11T00:00:00Z'
  curator: codex
  action: MINTED_TRAITMECH_ID
  changes: Minted gelatinase activity as a DOI-backed TraitRecord after a repository-wide
    duplicate review covering ignored and hidden files; METPO has no exact gelatinase
    activity class yet.
  llm_assisted: true