identifier: traitmech:000172
label: serine arylamidase activity
definition: A physiological enzyme-activity phenotype in which a cell produces active
  serine arylamidase enzymes that hydrolyze serine arylamide substrates.
definition_source: DOI:10.1099/ijsem.0.006017
trait_category: PHYSIOLOGY
term_kind: CLASS
mapping_status: PROPOSED
parent_traits:
- METPO:1000059
synonyms:
- synonym_text: serine arylamidase
  synonym_type: RELATED_SYNONYM
  source: DOI:10.1099/ijsem.0.006017
evidence:
- reference: DOI:10.1099/ijsem.0.006017
  snippet: 'enzymatic activities are present for: α-galactosidase, N-acetyl-β-glucosaminidase,
    arginine arylamidase, proline arylamidase, leucyl glycine arylamidase, phenylalanine
    arylamidase, leucine arylamidase, tyrosine arylamidase, alanine arylamidase, glycine
    arylamidase, histidine arylamidase, glutamyl glutamic acid arylamidase, serine
    arylamidase, valine arylamidase, cysteine arylamidase, esterase, esterase lipase,
    alpha-chymotrypsin'
  notes: Srinivasan et al. listed serine arylamidase among enzymatic activities present
    in the Amygdalobacter indicium species description, supporting the API arylamidase
    row as a directly assayed bacterial enzyme-activity phenotype.
- reference: DOI:10.1128/JCM.40.9.3427-3431.2002
  snippet: When the API rapid ID32A system was used, all eight strains displayed activity
    for alanine arylamidase, arginine arylamidase, α-glucosidase, glycine arylamidase,
    histidine arylamidase, leucine arylamidase, leucylglycine arylamidase, proline
    arylamidase, phenylalanine arylamidase, serine arylamidase, and tyrosine arylamidase
  notes: Hall et al. reported serine arylamidase activity in all eight Actinomyces
    cardiffensis clinical isolates tested with the API rapid ID32A system.
canonical_examples:
- taxon_id: NCBITaxon:3029272
  taxon_label: Amygdalobacter indicium
  note: Srinivasan et al. reported Amygdalobacter indicium as positive for serine
    arylamidase activity in an enzyme activity panel.
  reference: DOI:10.1099/ijsem.0.006017
discussions:
- discussion_id: serine-arylamidase-activity-xref-gap
  prompt: Resolve an exact external ontology class for serine arylamidase activity
    before adding a TraitRecord xref.
  kind: CURATION_TODO
  status: OPEN
  rationale: GO:0004177 covers broad aminopeptidase activity at molecular-function
    scope, and no live GO class provides an exact residue-specific serine arylamidase
    production phenotype at organism-level scope.
  posed_by: codex
  posed_date: '2026-09-12'
curation_history:
- timestamp: '2026-09-12T13:59:47Z'
  curator: codex
  action: MINTED_TRAITMECH_ID
  changes: Minted serine arylamidase activity as a DOI-backed TraitRecord after a
    repository-wide duplicate review covering ignored and hidden files; METPO has
    no exact serine arylamidase activity class yet and the placeholder is reserved
    in proposals/metpo_traitmech_v49.
  llm_assisted: true