DB00001 BTD00024 BIOD00024 Lepirudin Lepirudin is identical to natural hirudin except for substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63. It is produced via yeast cells. Bayer ceased the production of lepirudin (Refludan) effective May 31, 2012. 138068-37-8 Y43GF64R34 liquid approved

16244762 Smythe MA, Stephens JL, Koerber JM, Mattson JC: A comparison of lepirudin and argatroban outcomes. Clin Appl Thromb Hemost. 2005 Oct;11(4):371-4.

16690967 Tardy B, Lecompte T, Boelhen F, Tardy-Poncet B, Elalamy I, Morange P, Gruel Y, Wolf M, Francois D, Racadot E, Camarasa P, Blouch MT, Nguyen F, Doubine S, Dutrillaux F, Alhenc-Gelas M, Martin-Toutain I, Bauters A, Ffrench P, de Maistre E, Grunebaum L, Mouton C, Huisse MG, Gouault-Heilmann M, Lucke V: Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin. Blood. 2006 Sep 1;108(5):1492-6. Epub 2006 May 11.

16241940 Lubenow N, Eichler P, Lietz T, Greinacher A: Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3. J Thromb Haemost. 2005 Nov;3(11):2428-36.

http://books.google.com/books?id=iadLoXoQkWEC&pg=PA440 For the treatment of heparin-induced thrombocytopenia Lepirudin is used to break up clots and to reduce thrombocytopenia. It binds to thrombin and prevents thrombus or clot formation. It is a highly potent, selective, and essentially irreversible inhibitor of thrombin and clot-bond thrombin. Lepirudin requires no cofactor for its anticoagulant action. Lepirudin is a recombinant form of hirudin, an endogenous anticoagulant found in medicinal leeches. Lepirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade. The inhibition of thrombin prevents the blood clotting cascade. In case of overdose (eg, suggested by excessively high aPTT values) the risk of bleeding is increased. Lepirudin is thought to be metabolized by release of amino acids via catabolic hydrolysis of the parent drug. However, con-clusive data are not available. About 48% of the administration dose is excreted in the urine which consists of unchanged drug (35%) and other fragments of the parent drug. Bioavailability is 100% following injection. Approximately 1.3 hours Lepirudin is thought to be metabolized by release of amino acids via catabolic hydrolysis of the parent drug. About 48% of the administration dose is excreted in the urine which consists of unchanged drug (35%) and other fragments of the parent drug. * 12.2 L [Healthy young subjects (n = 18, age 18-60 years)] * 18.7 L [Healthy elderly subjects (n = 10, age 65-80 years)] * 18 L [Renally impaired patients (n = 16, creatinine clearance below 80 mL/min)] * 32.1 L [HIT patients (n = 73)] * 164 ml/min [Healthy 18-60 yrs] * 139 ml/min [Healthy 65-80 yrs] * 61 ml/min [renal impaired] * 114 ml/min [HIT (Heparin-induced thrombocytopenia)] Peptides Organic Compounds Organic Acids Carboxylic Acids and Derivatives Amino Acids, Peptides, and Analogues Hirudin variant-1 Lepirudin recombinant Refludan Bayer 02240996 2000-01-31 2013-07-26 Powder, for solution 50 mg Intravenous false false true Canada DPD Refludan Celgene Europe Limited EMEA/H/C/000122 EU/1/97/035/001 1997-03-13 2012-07-27 Injection, solution, concentrate 50 mg Intravenous false false false EU EMA Refludan Celgene Europe Limited EMEA/H/C/000122 EU/1/97/035/002 1997-03-13 2012-07-27 Injection, solution, concentrate 50 mg Intravenous false false false EU EMA Refludan Celgene Europe Limited EMEA/H/C/000122 EU/1/97/035/003 1997-03-13 2012-07-27 Injection, solution, concentrate 20 mg Intravenous false false false EU EMA Refludan Celgene Europe Limited EMEA/H/C/000122 EU/1/97/035/004 1997-03-13 2012-07-27 Injection, solution, concentrate 20 mg Intravenous false false false EU EMA Refludan Lepirudin Refludan Lepirudin Refludan Lepirudin Refludan Lepirudin Refludan Lepirudin Bayer Healthcare http://www.bayerhealthcare.com Berlex Labs http://www.berlex.com Bayer healthcare pharmaceuticals inc Refludan 50 mg vial 273.19 vial Amino Acids, Peptides, and Proteins D000602 Anticoagulants D000925 Antithrombin Proteins D058833 Antithrombins D000991 Blood and Blood Forming Organs Cardiovascular Agents D002317 Enzyme Inhibitors D004791 Fibrin Modulating Agents D050299 Hematologic Agents D006401 Peptides D010455 Protease Inhibitors D011480 Proteins D011506 Serine Proteinase Inhibitors D015842 Serpins D015843 Humans and other mammals

Injection, solution, concentrate

Intravenous 20 mg

Injection, solution, concentrate

Intravenous 50 mg

Powder, for solution

Intravenous 50 mg Direct thrombin inhibitors ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS BLOOD AND BLOOD FORMING ORGANS //s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00001.pdf?1265924858 //s3-us-west-2.amazonaws.com/drugbank/msds/DB00001.pdf?1368416245 5180668 United States 1993-01-19 2010-01-19 false DB01323 St. John's Wort The metabolism of Lepirudin can be increased when combined with St. John's Wort. DB00346 Alfuzosin The serum concentration of Alfuzosin can be increased when it is combined with Lepirudin. DB13783 Acemetacin The risk or severity of bleeding can be increased when Lepirudin is combined with Acemetacin. DB06605 Apixaban Apixaban may increase the anticoagulant activities of Lepirudin. DB06695 Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Lepirudin. DB09075 Edoxaban Edoxaban may increase the anticoagulant activities of Lepirudin. DB06228 Rivaroxaban Lepirudin may increase the anticoagulant activities of Rivaroxaban. DB00227 Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Lepirudin. DB00013 Urokinase Urokinase may increase the anticoagulant activities of Lepirudin. DB09030 Vorapaxar The risk or severity of adverse effects can be increased when Vorapaxar is combined with Lepirudin. DB00683 Midazolam The serum concentration of Midazolam can be increased when it is combined with Lepirudin. DB00641 Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Lepirudin. DB00932 Tipranavir The serum concentration of Lepirudin can be decreased when it is combined with Tipranavir. DB00248 Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Lepirudin. DB01200 Bromocriptine The serum concentration of Bromocriptine can be increased when it is combined with Lepirudin. DB00320 Dihydroergotamine The serum concentration of Dihydroergotamine can be increased when it is combined with Lepirudin. DB00696 Ergotamine The serum concentration of Ergotamine can be increased when it is combined with Lepirudin. DB01049 Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Lepirudin. DB01253 Ergonovine The serum concentration of Ergonovine can be increased when it is combined with Lepirudin. DB00353 Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Lepirudin. DB00897 Triazolam The serum concentration of Triazolam can be increased when it is combined with Lepirudin. DB03404 Hemin Hemin may increase the anticoagulant activities of Lepirudin. DB00977 Ethinyl Estradiol The serum concentration of Ethinyl Estradiol can be decreased when it is combined with Lepirudin. DB01357 Mestranol The serum concentration of Mestranol can be decreased when it is combined with Lepirudin. DB00783 Estradiol The serum concentration of Estradiol can be decreased when it is combined with Lepirudin. DB00255 Diethylstilbestrol The serum concentration of Diethylstilbestrol can be decreased when it is combined with Lepirudin. DB00091 Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Lepirudin. DB10532 Garlic The serum concentration of Lepirudin can be decreased when it is combined with Garlic. DB00864 Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Lepirudin. DB00454 Pethidine The risk or severity of adverse effects can be increased when Lepirudin is combined with Pethidine. DB00404 Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Lepirudin. DB08873 Boceprevir The serum concentration of Lepirudin can be decreased when it is combined with Boceprevir. DB00564 Carbamazepine The metabolism of Lepirudin can be increased when combined with Carbamazepine. DB01211 Clarithromycin The therapeutic efficacy of Clarithromycin can be decreased when used in combination with Lepirudin. DB00705 Delavirdine The serum concentration of Delavirdine can be decreased when it is combined with Lepirudin. DB00269 Chlorotrianisene Chlorotrianisene may decrease the anticoagulant activities of Lepirudin. DB00286 Conjugated estrogens Conjugated estrogens may decrease the anticoagulant activities of Lepirudin. DB00655 Estrone Estrone may decrease the anticoagulant activities of Lepirudin. DB00890 Dienestrol Dienestrol may decrease the anticoagulant activities of Lepirudin. DB09369 Polyestradiol phosphate Polyestradiol phosphate may decrease the anticoagulant activities of Lepirudin. DB01645 Genistein Genistein may decrease the anticoagulant activities of Lepirudin. DB04575 Quinestrol Quinestrol may decrease the anticoagulant activities of Lepirudin. DB07931 Hexestrol Hexestrol may decrease the anticoagulant activities of Lepirudin. DB09317 Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Lepirudin. DB09318 Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Lepirudin. DB11478 Zeranol Zeranol may decrease the anticoagulant activities of Lepirudin. DB11674 Equol Equol may decrease the anticoagulant activities of Lepirudin. DB12179 Secoisolariciresinol Secoisolariciresinol may decrease the anticoagulant activities of Lepirudin. DB13182 Daidzein Daidzein may decrease the anticoagulant activities of Lepirudin. DB13386 Epimestrol Epimestrol may decrease the anticoagulant activities of Lepirudin. DB04573 Estriol Estriol may decrease the anticoagulant activities of Lepirudin. DB12487 Promestriene Promestriene may decrease the anticoagulant activities of Lepirudin. DB13143 Methallenestril Methallenestril may decrease the anticoagulant activities of Lepirudin. DB13418 Moxestrol Moxestrol may decrease the anticoagulant activities of Lepirudin. DB13952 Estradiol acetate Estradiol acetate may decrease the anticoagulant activities of Lepirudin. DB13954 Estradiol cypionate Estradiol cypionate may decrease the anticoagulant activities of Lepirudin. DB13956 Estradiol valerate Estradiol valerate may decrease the anticoagulant activities of Lepirudin. DB09381 Estrogens, esterified Estrogens, esterified may decrease the anticoagulant activities of Lepirudin. DB06401 Bazedoxifene Bazedoxifene may decrease the anticoagulant activities of Lepirudin. DB04865 Omacetaxine mepesuccinate The risk or severity of bleeding can be increased when Lepirudin is combined with Omacetaxine mepesuccinate. DB01149 Nefazodone The serum concentration of Nefazodone can be increased when it is combined with Lepirudin. DB06692 Aprotinin The therapeutic efficacy of Lepirudin can be decreased when used in combination with Aprotinin. DB13943 Testosterone cypionate The therapeutic efficacy of Lepirudin can be increased when used in combination with Testosterone cypionate. DB13944 Testosterone enanattributese The therapeutic efficacy of Lepirudin can be increased when used in combination with Testosterone enanattributese. DB01431 Allylestrenol The therapeutic efficacy of Lepirudin can be decreased when used in combination with Allylestrenol. DB00294 Etonogestrel The therapeutic efficacy of Lepirudin can be decreased when used in combination with Etonogestrel. DB00603 Medroxyprogesterone acetate The therapeutic efficacy of Lepirudin can be decreased when used in combination with Medroxyprogesterone acetate. DB00396 Progesterone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Progesterone. DB00717 Norethisterone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Norethisterone. DB06789 Hydroxyprogesterone caproate The therapeutic efficacy of Lepirudin can be decreased when used in combination with Hydroxyprogesterone caproate. DB00304 Desogestrel The therapeutic efficacy of Lepirudin can be decreased when used in combination with Desogestrel. DB00378 Dydrogesterone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Dydrogesterone. DB06730 Gestodene The therapeutic efficacy of Lepirudin can be decreased when used in combination with Gestodene. DB11372 Altrenogest The therapeutic efficacy of Lepirudin can be decreased when used in combination with Altrenogest. DB11619 Gestrinone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Gestrinone. DB09124 Medrogestone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Medrogestone. DB11636 Nomegestrol The therapeutic efficacy of Lepirudin can be decreased when used in combination with Nomegestrol. DB13230 Gestonorone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Gestonorone. DB13533 Methylestrenolone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Methylestrenolone. DB13563 Norgestrienone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Norgestrienone. DB13602 Promegestone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Promegestone. DB13857 Demegestone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Demegestone. DB00351 Megestrol acetate The therapeutic efficacy of Lepirudin can be decreased when used in combination with Megestrol acetate. DB00367 Levonorgestrel The therapeutic efficacy of Lepirudin can be decreased when used in combination with Levonorgestrel. DB09123 Dienogest The therapeutic efficacy of Lepirudin can be decreased when used in combination with Dienogest. DB01395 Drospirenone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Drospirenone. DB12474 Lynestrenol The therapeutic efficacy of Lepirudin can be decreased when used in combination with Lynestrenol. DB13528 Chlormadinone The therapeutic efficacy of Lepirudin can be decreased when used in combination with Chlormadinone. DB13685 Quingestanol The therapeutic efficacy of Lepirudin can be decreased when used in combination with Quingestanol. DB13866 Ethynodiol The therapeutic efficacy of Lepirudin can be decreased when used in combination with Ethynodiol. DB13946 Testosterone undecanoate The therapeutic efficacy of Lepirudin can be increased when used in combination with Testosterone undecanoate. DB08931 Riociguat The serum concentration of Riociguat can be increased when it is combined with Lepirudin. DB00203 Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Lepirudin. DB06287 Temsirolimus The risk or severity of adverse effects can be increased when Lepirudin is combined with Temsirolimus. DB00343 Diltiazem The metabolism of Diltiazem can be decreased when combined with Lepirudin. DB00661 Verapamil The metabolism of Verapamil can be decreased when combined with Lepirudin. DB00686 Pentosan Polysulfate Pentosan Polysulfate may increase the anticoagulant activities of Lepirudin. DB09568 Omega-3-carboxylic acids The therapeutic efficacy of Lepirudin can be increased when used in combination with Omega-3-carboxylic acids. DB00321 Amitriptyline The serum concentration of Amitriptyline can be increased when it is combined with Lepirudin. DB00344 Protriptyline The serum concentration of Protriptyline can be increased when it is combined with Lepirudin. DB00458 Imipramine The serum concentration of Imipramine can be increased when it is combined with Lepirudin. DB00540 Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Lepirudin. DB00726 Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Lepirudin. DB01142 Doxepin The serum concentration of Doxepin can be increased when it is combined with Lepirudin. DB01151 Desipramine The serum concentration of Desipramine can be increased when it is combined with Lepirudin. DB01242 Clomipramine The serum concentration of Clomipramine can be increased when it is combined with Lepirudin. DB09016 Butriptyline The serum concentration of Butriptyline can be increased when it is combined with Lepirudin. DB13114 Amitriptylinoxide The serum concentration of Amitriptylinoxide can be increased when it is combined with Lepirudin. DB13384 Melitracen The serum concentration of Melitracen can be increased when it is combined with Lepirudin. DB08996 Dimetacrine The serum concentration of Dimetacrine can be increased when it is combined with Lepirudin. DB04836 Amineptine The serum concentration of Amineptine can be increased when it is combined with Lepirudin. DB09167 Dosulepin The serum concentration of Dosulepin can be increased when it is combined with Lepirudin. DB09289 Tianeptine The serum concentration of Tianeptine can be increased when it is combined with Lepirudin. DB12930 Opipramol The serum concentration of Opipramol can be increased when it is combined with Lepirudin. DB13225 Dibenzepin The serum concentration of Dibenzepin can be increased when it is combined with Lepirudin. DB13411 Lofepramine The serum concentration of Lofepramine can be increased when it is combined with Lepirudin. DB13496 Iprindole The serum concentration of Iprindole can be increased when it is combined with Lepirudin. DB00543 Amoxapine The serum concentration of Amoxapine can be increased when it is combined with Lepirudin. DB01048 Abacavir The serum concentration of Abacavir can be decreased when it is combined with Lepirudin. DB00531 Cyclophosphamide The risk or severity of adverse effects can be increased when Lepirudin is combined with Cyclophosphamide. DB00390 Digoxin The serum concentration of Digoxin can be increased when it is combined with Lepirudin. DB00109 Enfuvirtide The serum concentration of Enfuvirtide can be increased when it is combined with Lepirudin. DB06414 Etravirine The serum concentration of Etravirine can be decreased when it is combined with Lepirudin. DB01254 Dasatinib Dasatinib may increase the anticoagulant activities of Lepirudin. DB01609 Deferasirox The risk or severity of adverse effects can be increased when Lepirudin is combined with Deferasirox. DB03619 Deoxycholic Acid The risk or severity of adverse effects can be increased when Lepirudin is combined with Deoxycholic Acid. DB00078 Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Lepirudin is combined with Ibritumomab tiuxetan. DB09053 Ibrutinib The risk or severity of adverse effects can be increased when Ibrutinib is combined with Lepirudin. DB09079 Nintedanib The risk or severity of adverse effects can be increased when Lepirudin is combined with Nintedanib. DB08935 Obinutuzumab The risk or severity of adverse effects can be increased when Lepirudin is combined with Obinutuzumab. DB00048 Collagenase clostridium histolyticum The risk or severity of adverse effects can be increased when Lepirudin is combined with Collagenase clostridium histolyticum. DB06206 Sugammadex Sugammadex may increase the anticoagulant activities of Lepirudin. DB09211 Limaprost The risk or severity of adverse effects can be increased when Limaprost is combined with Lepirudin. DB09070 Tibolone Tibolone may increase the anticoagulant activities of Lepirudin. DB00465 Ketorolac Ketorolac may increase the anticoagulant activities of Lepirudin. DB00586 Diclofenac Diclofenac may increase the anticoagulant activities of Lepirudin. DB00712 Flurbiprofen Flurbiprofen may increase the anticoagulant activities of Lepirudin. DB00963 Bromfenac Bromfenac may increase the anticoagulant activities of Lepirudin. DB06802 Nepafenac Nepafenac may increase the anticoagulant activities of Lepirudin. DB00005 Etanercept Etanercept may increase the anticoagulant activities of Lepirudin. DB00179 Masoprocol Masoprocol may increase the anticoagulant activities of Lepirudin. DB00210 Adapalene Adapalene may increase the anticoagulant activities of Lepirudin. DB00244 Mesalazine Mesalazine may increase the anticoagulant activities of Lepirudin. DB00328 Indomethacin Indomethacin may increase the anticoagulant activities of Lepirudin. DB00337 Pimecrolimus Pimecrolimus may increase the anticoagulant activities of Lepirudin. DB00461 Nabumetone Nabumetone may increase the anticoagulant activities of Lepirudin. DB00469 Tenoxicam Tenoxicam may increase the anticoagulant activities of Lepirudin. DB00482 Celecoxib Celecoxib may increase the anticoagulant activities of Lepirudin. DB00500 Tolmetin Tolmetin may increase the anticoagulant activities of Lepirudin. DB00533 Rofecoxib Rofecoxib may increase the anticoagulant activities of Lepirudin. DB00554 Piroxicam Piroxicam may increase the anticoagulant activities of Lepirudin. DB00573 Fenoprofen Fenoprofen may increase the anticoagulant activities of Lepirudin. DB00580 Valdecoxib Valdecoxib may increase the anticoagulant activities of Lepirudin. DB00605 Sulindac Sulindac may increase the anticoagulant activities of Lepirudin. DB00608 Chloroquine Chloroquine may increase the anticoagulant activities of Lepirudin. DB00688 Mycophenolate mofetil Mycophenolate mofetil may increase the anticoagulant activities of Lepirudin. DB00735 Naftifine Naftifine may increase the anticoagulant activities of Lepirudin. DB00744 Zileuton Zileuton may increase the anticoagulant activities of Lepirudin. DB00749 Etodolac Etodolac may increase the anticoagulant activities of Lepirudin. DB00768 Olopatadine Olopatadine may increase the anticoagulant activities of Lepirudin. DB00784 Mefenamic acid Mefenamic acid may increase the anticoagulant activities of Lepirudin. DB00788 Naproxen Naproxen may increase the anticoagulant activities of Lepirudin. DB00795 Sulfasalazine Sulfasalazine may increase the anticoagulant activities of Lepirudin. DB00812 Phenylbutazone Phenylbutazone may increase the anticoagulant activities of Lepirudin. DB00814 Meloxicam Meloxicam may increase the anticoagulant activities of Lepirudin. DB00821 Carprofen Carprofen may increase the anticoagulant activities of Lepirudin. DB00861 Diflunisal Diflunisal may increase the anticoagulant activities of Lepirudin. DB00870 Suprofen Suprofen may increase the anticoagulant activities of Lepirudin. DB00936 Salicylic acid Salicylic acid may increase the anticoagulant activities of Lepirudin. DB00939 Meclofenamic acid Meclofenamic acid may increase the anticoagulant activities of Lepirudin. DB00945 Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Lepirudin. DB00972 Azelastine Azelastine may increase the anticoagulant activities of Lepirudin. DB00991 Oxaprozin Oxaprozin may increase the anticoagulant activities of Lepirudin. DB01009 Ketoprofen Ketoprofen may increase the anticoagulant activities of Lepirudin. DB01014 Balsalazide Balsalazide may increase the anticoagulant activities of Lepirudin. DB01024 Mycophenolic acid Mycophenolic acid may increase the anticoagulant activities of Lepirudin. DB01050 Ibuprofen Ibuprofen may increase the anticoagulant activities of Lepirudin. DB01097 Leflunomide Leflunomide may increase the anticoagulant activities of Lepirudin. DB01250 Olsalazine Olsalazine may increase the anticoagulant activities of Lepirudin. DB01283 Lumiracoxib Lumiracoxib may increase the anticoagulant activities of Lepirudin. DB01397 Magnesium salicylate Magnesium salicylate may increase the anticoagulant activities of Lepirudin. DB01399 Salsalate Salsalate may increase the anticoagulant activities of Lepirudin. DB01401 Choline magnesium trisalicylate Choline magnesium trisalicylate may increase the anticoagulant activities of Lepirudin. DB01435 Antipyrine Antipyrine may increase the anticoagulant activities of Lepirudin. DB01600 Tiaprofenic acid Tiaprofenic acid may increase the anticoagulant activities of Lepirudin. DB01628 Etoricoxib Etoricoxib may increase the anticoagulant activities of Lepirudin. DB01816 Castanospermine Castanospermine may increase the anticoagulant activities of Lepirudin. DB02709 Resveratrol Resveratrol may increase the anticoagulant activities of Lepirudin. DB03585 Oxyphenbutazone Oxyphenbutazone may increase the anticoagulant activities of Lepirudin. DB04552 Niflumic Acid Niflumic Acid may increase the anticoagulant activities of Lepirudin. DB04743 Nimesulide Nimesulide may increase the anticoagulant activities of Lepirudin. DB04812 Benoxaprofen Benoxaprofen may increase the anticoagulant activities of Lepirudin. DB04817 Metamizole Metamizole may increase the anticoagulant activities of Lepirudin. DB04828 Zomepirac Zomepirac may increase the anticoagulant activities of Lepirudin. DB04951 Pirfenidone Pirfenidone may increase the anticoagulant activities of Lepirudin. DB05073 SRT501 SRT501 may increase the anticoagulant activities of Lepirudin. DB05173 PTC299 PTC299 may increase the anticoagulant activities of Lepirudin. DB05289 Tarenflurbil Tarenflurbil may increase the anticoagulant activities of Lepirudin. DB05676 Apremilast Apremilast may increase the anticoagulant activities of Lepirudin. DB05767 Andrographolide Andrographolide may increase the anticoagulant activities of Lepirudin. DB06196 Icatibant Icatibant may increase the anticoagulant activities of Lepirudin. DB06246 Exisulind Exisulind may increase the anticoagulant activities of Lepirudin. DB06725 Lornoxicam Lornoxicam may increase the anticoagulant activities of Lepirudin. DB06736 Aceclofenac Aceclofenac may increase the anticoagulant activities of Lepirudin. DB06737 Zaltoprofen Zaltoprofen may increase the anticoagulant activities of Lepirudin. DB06739 Seratrodast Seratrodast may increase the anticoagulant activities of Lepirudin. DB07402 Azapropazone Azapropazone may increase the anticoagulant activities of Lepirudin. DB07477 Felbinac Felbinac may increase the anticoagulant activities of Lepirudin. DB07615 Tranilast Tranilast may increase the anticoagulant activities of Lepirudin. DB07767 Ferulic acid Ferulic acid may increase the anticoagulant activities of Lepirudin. DB08439 Parecoxib Parecoxib may increase the anticoagulant activities of Lepirudin. DB08797 Salicylamide Salicylamide may increase the anticoagulant activities of Lepirudin. DB08880 Teriflunomide Teriflunomide may increase the anticoagulant activities of Lepirudin. DB08921 (4R)-limonene (4R)-limonene may increase the anticoagulant activities of Lepirudin. DB08940 Kebuzone Kebuzone may increase the anticoagulant activities of Lepirudin. DB08942 Isoxicam Isoxicam may increase the anticoagulant activities of Lepirudin. DB08951 Indoprofen Indoprofen may increase the anticoagulant activities of Lepirudin. DB08955 Ibuproxam Ibuproxam may increase the anticoagulant activities of Lepirudin. DB08976 Floctafenine Floctafenine may increase the anticoagulant activities of Lepirudin. DB08981 Fenbufen Fenbufen may increase the anticoagulant activities of Lepirudin. DB08984 Etofenamate Etofenamate may increase the anticoagulant activities of Lepirudin. DB08991 Epirizole Epirizole may increase the anticoagulant activities of Lepirudin. DB09212 Loxoprofen Loxoprofen may increase the anticoagulant activities of Lepirudin. DB09215 Droxicam Droxicam may increase the anticoagulant activities of Lepirudin. DB09216 Tolfenamic Acid Tolfenamic Acid may increase the anticoagulant activities of Lepirudin. DB09218 Clonixin Clonixin may increase the anticoagulant activities of Lepirudin. DB09288 Propacetamol Propacetamol may increase the anticoagulant activities of Lepirudin. DB11358 Evening primrose oil Evening primrose oil may increase the anticoagulant activities of Lepirudin. DB11444 Orgotein Orgotein may increase the anticoagulant activities of Lepirudin. DB11466 Tepoxalin Tepoxalin may increase the anticoagulant activities of Lepirudin. DB11518 Flunixin Flunixin may increase the anticoagulant activities of Lepirudin. DB11672 Curcumin Curcumin may increase the anticoagulant activities of Lepirudin. DB11687 E-6201 E-6201 may increase the anticoagulant activities of Lepirudin. DB11785 Anisodamine Anisodamine may increase the anticoagulant activities of Lepirudin. DB11952 Duvelisib Duvelisib may increase the anticoagulant activities of Lepirudin. DB12025 Triptolide Triptolide may increase the anticoagulant activities of Lepirudin. DB12094 Semapimod Semapimod may increase the anticoagulant activities of Lepirudin. DB12160 Bucillamine Bucillamine may increase the anticoagulant activities of Lepirudin. DB12406 Lisofylline Lisofylline may increase the anticoagulant activities of Lepirudin. DB12445 Nitroaspirin Nitroaspirin may increase the anticoagulant activities of Lepirudin. DB12598 Nafamostat Nafamostat may increase the anticoagulant activities of Lepirudin. DB12617 Mizoribine Mizoribine may increase the anticoagulant activities of Lepirudin. DB12618 Apocynin Apocynin may increase the anticoagulant activities of Lepirudin. DB12779 Higenamine Higenamine may increase the anticoagulant activities of Lepirudin. DB13001 Tinoridine Tinoridine may increase the anticoagulant activities of Lepirudin. DB13063 Parthenolide Parthenolide may increase the anticoagulant activities of Lepirudin. DB13131 Serrapeptase Serrapeptase may increase the anticoagulant activities of Lepirudin. DB13167 Alclofenac Alclofenac may increase the anticoagulant activities of Lepirudin. DB13217 Fentiazac Fentiazac may increase the anticoagulant activities of Lepirudin. DB13227 Tribenoside Tribenoside may increase the anticoagulant activities of Lepirudin. DB13232 Suxibuzone Suxibuzone may increase the anticoagulant activities of Lepirudin. DB13286 Bumadizone Bumadizone may increase the anticoagulant activities of Lepirudin. DB13314 Alminoprofen Alminoprofen may increase the anticoagulant activities of Lepirudin. DB13317 Flunoxaprofen Flunoxaprofen may increase the anticoagulant activities of Lepirudin. DB13346 Bufexamac Bufexamac may increase the anticoagulant activities of Lepirudin. DB13364 Feprazone Feprazone may increase the anticoagulant activities of Lepirudin. DB13371 Difenpiramide Difenpiramide may increase the anticoagulant activities of Lepirudin. DB13407 Nifenazone Nifenazone may increase the anticoagulant activities of Lepirudin. DB13432 Lonazolac Lonazolac may increase the anticoagulant activities of Lepirudin. DB13481 Tenidap Tenidap may increase the anticoagulant activities of Lepirudin. DB13501 Bendazac Bendazac may increase the anticoagulant activities of Lepirudin. DB13514 Pranoprofen Pranoprofen may increase the anticoagulant activities of Lepirudin. DB13524 Propyphenazone Propyphenazone may increase the anticoagulant activities of Lepirudin. DB13527 Proglumetacin Proglumetacin may increase the anticoagulant activities of Lepirudin. DB13538 Guacetisal Guacetisal may increase the anticoagulant activities of Lepirudin. DB13542 Bevonium Bevonium may increase the anticoagulant activities of Lepirudin. DB13544 Ethenzamide Ethenzamide may increase the anticoagulant activities of Lepirudin. DB13612 Carbaspirin calcium Carbaspirin calcium may increase the anticoagulant activities of Lepirudin. DB13629 Mofebutazone Mofebutazone may increase the anticoagulant activities of Lepirudin. DB13649 Proquazone Proquazone may increase the anticoagulant activities of Lepirudin. DB13657 Benorilate Benorilate may increase the anticoagulant activities of Lepirudin. DB13722 Pirprofen Pirprofen may increase the anticoagulant activities of Lepirudin. DB13860 Imidazole salicylate Imidazole salicylate may increase the anticoagulant activities of Lepirudin. DB09084 Benzydamine Benzydamine may increase the anticoagulant activities of Lepirudin. DB14043 Palmidrol Palmidrol may increase the anticoagulant activities of Lepirudin. DB11133 Omega-3 fatty acids Omega-3 fatty acids may increase the anticoagulant activities of Lepirudin. DB00163 Vitamin E Vitamin E may increase the anticoagulant activities of Lepirudin. DB00081 Tositumomab The risk or severity of adverse effects can be increased when Lepirudin is combined with Tositumomab. DB00006 Bivalirudin Bivalirudin may increase the anticoagulant activities of Lepirudin. DB00054 Abciximab Abciximab may increase the anticoagulant activities of Lepirudin. DB00102 Becaplermin Becaplermin may increase the anticoagulant activities of Lepirudin. DB00266 Dicoumarol Dicoumarol may increase the anticoagulant activities of Lepirudin. DB00278 Argatroban Argatroban may increase the anticoagulant activities of Lepirudin. DB00407 Ardeparin Ardeparin may increase the anticoagulant activities of Lepirudin. DB00498 Phenindione Phenindione may increase the anticoagulant activities of Lepirudin. DB00569 Fondaparinux Fondaparinux sodium may increase the anticoagulant activities of Lepirudin. DB00682 Warfarin Warfarin may increase the anticoagulant activities of Lepirudin. DB00946 Phenprocoumon Phenprocoumon may increase the anticoagulant activities of Lepirudin. DB00974 Edetic Acid Edetic Acid may increase the anticoagulant activities of Lepirudin. DB01109 Heparin Heparin may increase the anticoagulant activities of Lepirudin. DB01225 Enoxaparin Enoxaparin may increase the anticoagulant activities of Lepirudin. DB01418 Acenocoumarol Acenocoumarol may increase the anticoagulant activities of Lepirudin. DB04272 Citric Acid Citric Acid may increase the anticoagulant activities of Lepirudin. DB04898 Ximelagatran Ximelagatran may increase the anticoagulant activities of Lepirudin. DB05099 Ancrod Ancrod may increase the anticoagulant activities of Lepirudin. DB06154 Pentaerythritol Tetranitrate Pentaerythritol Tetranitrate may increase the anticoagulant activities of Lepirudin. DB06271 Sulodexide Sulodexide may increase the anticoagulant activities of Lepirudin. DB06406 Idraparinux Idraparinux may increase the anticoagulant activities of Lepirudin. DB06635 Otamixaban Otamixaban may increase the anticoagulant activities of Lepirudin. DB06754 Danaparoid Danaparoid may increase the anticoagulant activities of Lepirudin. DB06779 Dalteparin Dalteparin may increase the anticoagulant activities of Lepirudin. DB08794 Ethyl biscoumacetate Ethyl biscoumacetate may increase the anticoagulant activities of Lepirudin. DB08813 Nadroparin Nadroparin may increase the anticoagulant activities of Lepirudin. DB09255 Dextran Dextran may increase the anticoagulant activities of Lepirudin. DB09259 Reviparin Reviparin may increase the anticoagulant activities of Lepirudin. DB09261 Certoparin Certoparin may increase the anticoagulant activities of Lepirudin. DB11095 Desirudin Desirudin may increase the anticoagulant activities of Lepirudin. DB11268 Protocatechualdehyde Protocatechualdehyde may increase the anticoagulant activities of Lepirudin. DB11312 Protein C Protein C may increase the anticoagulant activities of Lepirudin. DB11598 Antithrombin III human Antithrombin III human may increase the anticoagulant activities of Lepirudin. DB11984 Letaxaban Letaxaban may increase the anticoagulant activities of Lepirudin. DB12289 Darexaban Darexaban may increase the anticoagulant activities of Lepirudin. DB12831 Gabexate Gabexate may increase the anticoagulant activities of Lepirudin. DB13124 Troxerutin Troxerutin may increase the anticoagulant activities of Lepirudin. DB13136 Fluindione Fluindione may increase the anticoagulant activities of Lepirudin. DB13149 Protein S human Protein S human may increase the anticoagulant activities of Lepirudin. DB13616 Melagatran Melagatran may increase the anticoagulant activities of Lepirudin. DB09125 Potassium Citrate Potassium Citrate may increase the anticoagulant activities of Lepirudin. DB09154 Sodium Citrate Sodium Citrate may increase the anticoagulant activities of Lepirudin. DB00233 Aminosalicylic Acid Aminosalicylic Acid may increase the anticoagulant activities of Lepirudin. DB06251 Dersalazine Dersalazine may increase the anticoagulant activities of Lepirudin. DB06807 Phenyl aminosalicylate Phenyl aminosalicylate may increase the anticoagulant activities of Lepirudin. DB13509 Aloxiprin Aloxiprin may increase the anticoagulant activities of Lepirudin. DB13864 Hemoglobin crosfumaril Hemoglobin crosfumaril may increase the anticoagulant activities of Lepirudin. DB09543 Methyl salicylate Methyl salicylate may increase the anticoagulant activities of Lepirudin. DB11079 Trolamine salicylate Trolamine salicylate may increase the anticoagulant activities of Lepirudin. DB00009 Alteplase Alteplase may increase the anticoagulant activities of Lepirudin. DB00015 Reteplase Reteplase may increase the anticoagulant activities of Lepirudin. DB00029 Anistreplase Anistreplase may increase the anticoagulant activities of Lepirudin. DB00031 Tenecteplase Tenecteplase may increase the anticoagulant activities of Lepirudin. DB00055 Drotrecogin alfa Drotrecogin alfa may increase the anticoagulant activities of Lepirudin. DB00208 Ticlopidine Ticlopidine may increase the anticoagulant activities of Lepirudin. DB00775 Tirofiban Tirofiban may increase the anticoagulant activities of Lepirudin. DB01166 Cilostazol Cilostazol may increase the anticoagulant activities of Lepirudin. DB04932 Defibrotide Defibrotide may increase the anticoagulant activities of Lepirudin. DB06822 Tinzaparin Tinzaparin may increase the anticoagulant activities of Lepirudin. DB13199 Brinase Brinase may increase the anticoagulant activities of Lepirudin. DB13646 Saruplase Saruplase may increase the anticoagulant activities of Lepirudin. DB00086 Streptokinase Streptokinase may increase the anticoagulant activities of Lepirudin. DB00261 Anagrelide Anagrelide may increase the anticoagulant activities of Lepirudin. DB00412 Rosiglitazone Rosiglitazone may increase the anticoagulant activities of Lepirudin. DB04925 Desmoteplase Desmoteplase may increase the anticoagulant activities of Lepirudin. DB05254 Fibrinolysin Fibrinolysin may increase the anticoagulant activities of Lepirudin. DB06081 Caplacizumab Caplacizumab may increase the anticoagulant activities of Lepirudin. DB06392 eplivanserine eplivanserine may increase the anticoagulant activities of Lepirudin. DB06543 Astaxanthin Astaxanthin may increase the anticoagulant activities of Lepirudin. DB09005 Batroxobin Batroxobin may increase the anticoagulant activities of Lepirudin. DB12017 Ozagrel Ozagrel may increase the anticoagulant activities of Lepirudin. DB12163 Sarpogrelate Sarpogrelate may increase the anticoagulant activities of Lepirudin. DB12177 Eplivanserin Eplivanserin may increase the anticoagulant activities of Lepirudin. DB00063 Eptifibatide Eptifibatide may increase the anticoagulant activities of Lepirudin. DB00374 Treprostinil Treprostinil may increase the anticoagulant activities of Lepirudin. DB00758 Clopidogrel Clopidogrel may increase the anticoagulant activities of Lepirudin. DB00975 Dipyridamole Dipyridamole may increase the anticoagulant activities of Lepirudin. DB01088 Iloprost Iloprost may increase the anticoagulant activities of Lepirudin. DB01240 Epoprostenol Epoprostenol may increase the anticoagulant activities of Lepirudin. DB05229 Beraprost Beraprost may increase the anticoagulant activities of Lepirudin. DB06209 Prasugrel Prasugrel may increase the anticoagulant activities of Lepirudin. DB06441 Cangrelor Cangrelor may increase the anticoagulant activities of Lepirudin. DB08814 Triflusal Triflusal may increase the anticoagulant activities of Lepirudin. DB08816 Ticagrelor Ticagrelor may increase the anticoagulant activities of Lepirudin. DB08994 Ditazole Ditazole may increase the anticoagulant activities of Lepirudin. DB09258 Bemiparin Bemiparin may increase the anticoagulant activities of Lepirudin. DB09260 Parnaparin Parnaparin may increase the anticoagulant activities of Lepirudin. DB11362 Selexipag Selexipag may increase the anticoagulant activities of Lepirudin. DB12545 Indobufen Indobufen may increase the anticoagulant activities of Lepirudin. DB13275 Clorindione Clorindione may increase the anticoagulant activities of Lepirudin. DB13327 Picotamide Picotamide may increase the anticoagulant activities of Lepirudin. DB13347 Diphenadione Diphenadione may increase the anticoagulant activities of Lepirudin. DB13367 Cloricromen Cloricromen may increase the anticoagulant activities of Lepirudin. DB13451 Tioclomarol Tioclomarol may increase the anticoagulant activities of Lepirudin. DB00235 Milrinone Milrinone may increase the anticoagulant activities of Lepirudin. DB00751 Epinastine Epinastine may increase the anticoagulant activities of Lepirudin. DB00770 Alprostadil Alprostadil may increase the anticoagulant activities of Lepirudin. DB00806 Pentoxifylline Pentoxifylline may increase the anticoagulant activities of Lepirudin. DB01207 Ridogrel Ridogrel may increase the anticoagulant activities of Lepirudin. DB01236 Sevoflurane Sevoflurane may increase the anticoagulant activities of Lepirudin. DB04905 Tesmilifene Tesmilifene may increase the anticoagulant activities of Lepirudin. DB05266 Ibudilast Ibudilast may increase the anticoagulant activities of Lepirudin. DB08887 Icosapent ethyl Icosapent ethyl may increase the anticoagulant activities of Lepirudin. DB08954 Ifenprodil Ifenprodil may increase the anticoagulant activities of Lepirudin. DB09283 Trapidil Trapidil may increase the anticoagulant activities of Lepirudin. DB12092 Naftopidil Naftopidil may increase the anticoagulant activities of Lepirudin. DB12321 Ifetroban Ifetroban may increase the anticoagulant activities of Lepirudin. DB12465 Ketanserin Ketanserin may increase the anticoagulant activities of Lepirudin. DB12749 Butylphthalide Butylphthalide may increase the anticoagulant activities of Lepirudin. DB12771 Hydroxytyrosol Hydroxytyrosol may increase the anticoagulant activities of Lepirudin. DB13036 Ramatroban Ramatroban may increase the anticoagulant activities of Lepirudin. DB13400 Linsidomine Linsidomine may increase the anticoagulant activities of Lepirudin. DB13510 Buflomedil Buflomedil may increase the anticoagulant activities of Lepirudin. DB13929 Relcovaptan Relcovaptan may increase the anticoagulant activities of Lepirudin. DB13141 Ambroxol acefyllinate The serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Lepirudin. DB00277 Theophylline The serum concentration of Theophylline can be decreased when it is combined with Lepirudin. DB00651 Dyphylline The serum concentration of Dyphylline can be decreased when it is combined with Lepirudin. DB01223 Aminophylline The serum concentration of Aminophylline can be decreased when it is combined with Lepirudin. DB00313 Valproic Acid The serum concentration of Valproic Acid can be decreased when it is combined with Lepirudin. DB00495 Zidovudine The serum concentration of Zidovudine can be decreased when it is combined with Lepirudin. DB11051 Azficel-T The risk or severity of adverse effects can be increased when Lepirudin is combined with Azficel-T. >DB00001 sequence LVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIP EEYLQ Melting Point 65 °C Otto, A. & Seckler, R. Eur. J. Biochem. 202:67-73 (1991) Hydrophobicity -0.777 Isoelectric Point 4.04 Molecular Weight 6963.425 Molecular Formula C287H440N80O110S6 Drugs Product Database (DPD) 11916 PubChem Substance 46507011 KEGG Drug D06880 PharmGKB PA450195 UniProtKB P01050 Therapeutic Targets Database DAP000541 Wikipedia Lepirudin ChEMBL CHEMBL1201666 RxList http://www.rxlist.com/cgi/generic/lepirudin.htm Drugs.com http://www.drugs.com/cdi/lepirudin.html SMP00278 Lepirudin Action Pathway drug_action DB00001 Lepirudin DB01022 Phylloquinone DB01373 Calcium P00734 P00748 P02452 P03952 P03951 P00740 P00451 P12259 P00742 P02671 P02675 P02679 P00488 P05160 P00747 P00750 P08709 P13726 Q9BQB6 P38435 BE0000048 Prothrombin Human inhibitor

10505536 Turpie AG: Anticoagulants in acute coronary syndromes. Am J Cardiol. 1999 Sep 2;84(5A):2M-6M.

10912644 Warkentin TE: Venous thromboembolism in heparin-induced thrombocytopenia. Curr Opin Pulm Med. 2000 Jul;6(4):343-51.

11055889 Eriksson BI: New therapeutic options in deep vein thrombosis prophylaxis. Semin Hematol. 2000 Jul;37(3 Suppl 5):7-9.

11467439 Fabrizio MC: Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass. J Extra Corpor Technol. 2001 May;33(2):117-25.

11807012 Szaba FM, Smiley ST: Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo. Blood. 2002 Feb 1;99(3):1053-9.

11752352 Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.

yes Prothrombin Thrombospondin receptor activity Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. F2 11p11-q12 Secreted 1-24 5.7 70036.295 11 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:3535 GenAtlas F2 GenBank Gene Database M17262 GenBank Protein Database 339641 Guide to Pharmacology 2362 UniProtKB P00734 UniProt Accession THRB_HUMAN 3.4.21.5 Coagulation factor II >lcl|BSEQ0016004|Prothrombin MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFGE >lcl|BSEQ0016005|Prothrombin (F2) ATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGC CTTGTGCACAGCCAGCATGTGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGG GTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTGGAGCGAGAGTGC GTGGAGGAGACGTGCAGCTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACG GATGTGTTCTGGGCCAAGTACACAGCTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTT GCTGCATGTCTGGAAGGTAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTG AACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCT GAAATCAACTCCACTACCCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCC GACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAA TGCAGCATCCCTGTCTGTGGCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAA GGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAG TACCAGGGGCGCCTGGCGGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCA CAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAAC TTCTGCCGCAACCCAGACGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCT GGCGACTTTGGGTACTGCGACCTCAACTATTGTGAGGAGGCCGTGGAGGAGGAGACAGGA GATGGGCTGGATGAGGACTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTAC CAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAGACTGTGGGCTGCGACCT CTGTTCGAGAAGAAGTCGCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATC GACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTGGCAGGTGATG CTTTTCCGGAAGAGTCCCCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGG GTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAAT GACCTTCTGGTGCGCATTGGCAAGCACTCCCGCACCAGGTACGAGCGAAACATTGAAAAG ATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGAC CGGGACATTGCCCTGATGAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCT GTGTGTCTGCCCGACAGGGAGACGGCAGCCAGCTTGCTCCAGGCTGGATACAAGGGGCGG GTGACAGGCTGGGGCAACCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCC AGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACC CGGATCCGCATCACTGACAACATGTTCTGTGCTGGTTACAAGCCTGATGAAGGGAAACGA GGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAGAGCCCCTTTAACAAC CGCTGGTATCAAATGGGCATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATAT GGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTT GGAGAGTAG PF00594 Gla PF00051 Kringle PF00089 Trypsin PF09396 Thrombin_light component blood microparticle component extracellular matrix component Golgi lumen component cytosol component extracellular exosome component extracellular region component endoplasmic reticulum lumen component plasma membrane component extracellular space function thrombospondin receptor activity function calcium ion binding function serine-type endopeptidase activity function growth factor activity function receptor binding process negative regulation of platelet activation process regulation of cell shape process regulation of gene expression process blood coagulation process negative regulation of proteolysis process platelet activation process response to inactivity process positive regulation of blood coagulation process response to wounding process acute-phase response process positive regulation of cell growth process blood coagulation, intrinsic pathway process proteolysis process positive regulation of cell proliferation process positive regulation of protein phosphorylation process cell surface receptor signaling pathway process positive regulation of collagen biosynthetic process process cytosolic calcium ion homeostasis process positive regulation of phosphatidylinositol 3-kinase signaling process cellular response to mechanical stimulus process fibrinolysis process positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway process leukocyte migration process multicellular organismal development process positive regulation of reactive oxygen species metabolic process process cellular protein metabolic process process negative regulation of astrocyte differentiation process peptidyl-glutamic acid carboxylation process positive regulation of release of sequestered calcium ion into cytosol process post-translational protein modification process negative regulation of fibrinolysis process regulation of blood coagulation