MeSH ID	Tree ID	Name	Description	Comment	Counts [Template Drug]	Color
D000006	C23.888.592.612.054.200|C23.888.821.030.249	Abdomen, Acute	A clinical syndrome with acute abdominal pain that is severe, localized, and rapid in onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.	""	0	#FFFFFF
D000007	C26.017	Abdominal Injuries	General or unspecified injuries involving organs in the abdominal cavity.	""	0	#FFFFFF
D000008	C04.588.033	Abdominal Neoplasms	New abnormal growth of tissue in the ABDOMEN.	""	0	#FFFFFF
D000012	C16.320.565.398.500.440.500|C18.452.584.500.875.440.500|C18.452.584.563.500.440.500|C18.452.648.398.500.440.500	Abetalipoproteinemia	An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.	""	0	#FFFFFF
D000013	C16.131	Congenital Abnormalities	Malformations of organs or body parts during development in utero.	""	0	#FFFFFF
D000014	C16.131.042	Abnormalities, Drug-Induced	Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	""	0	#FFFFFF
D000015	C16.131.077	Abnormalities, Multiple	Congenital abnormalities that affect more than one organ or body structure.	""	0	#FFFFFF
D000016	C16.131.080|C26.733.031	Abnormalities, Radiation-Induced	Congenital changes in the morphology of organs produced by exposure to ionizing or non-ionizing radiation.	""	0	#FFFFFF
D000022	C12.050.703.039	Abortion, Spontaneous	Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.	""	0	#FFFFFF
D000026	C12.050.703.039.089	Abortion, Habitual	Three or more consecutive spontaneous abortions.	""	0	#FFFFFF
D000027	C12.050.703.039.093	Abortion, Incomplete	Premature loss of PREGNANCY in which not all the products of CONCEPTION have been expelled.	""	0	#FFFFFF
D000030	C12.050.703.039.173	Abortion, Missed	The retention in the UTERUS of a dead FETUS two months or more after its DEATH.	""	0	#FFFFFF
D000031	C01.674.173|C12.050.703.039.256|C12.050.703.700.173	Abortion, Septic	Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.	""	0	#FFFFFF
D000033	C12.050.703.090	Abortion, Threatened	UTERINE BLEEDING from a GESTATION of less than 20 weeks without any CERVICAL DILATATION. It is characterized by vaginal bleeding, lower back discomfort, or midline pelvic cramping and a risk factor for MISCARRIAGE.	""	0	#FFFFFF
D000034	C12.050.703.039.422|C22.021	Abortion, Veterinary	Premature expulsion of the FETUS in animals.	""	0	#FFFFFF
D000037	C12.050.703.420.078|C12.050.703.590.132	Abruptio Placentae	Premature separation of the normally implanted PLACENTA from the UTERUS. Signs of varying degree of severity include UTERINE BLEEDING, uterine MUSCLE HYPERTONIA, and FETAL DISTRESS or FETAL DEATH.	""	0	#FFFFFF
D000038	C01.830.025|C23.550.470.756.100	Abscess	Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.	""	0	#FFFFFF
D000039	C01.748.561.750.500|C01.830.025.675|C07.550.781.750.500|C08.730.561.750.500|C09.775.649.750.500	Peritonsillar Abscess	An accumulation of purulent material in the area between the PALATINE TONSIL and its capsule.	""	0	#FFFFFF
D000051	C17.800.865.070|C23.550.035	Acantholysis	Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.	""	0	#FFFFFF
D000052	C17.800.621.430.530.100	Acanthosis Nigricans	A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.	""	0	#FFFFFF
D000067011	C18.654.521.719	Severe Acute Malnutrition	Acute form of MALNUTRITION which usually affects children, characterized by a very low weight for height (below -3z scores of the median World Health Organization standards), visible severe wasting, or occurrence of nutritional EDEMA.  It can be a direct or indirect cause of fatality in children suffering from DIARRHEA and PNEUMONIA. Do not confuse with starvation, a condition in which the body is not getting enough food, usually for extended periods of time.	""	0	#FFFFFF
D000067208	C20.543.480.370.763	Shellfish Hypersensitivity	Allergic reaction to SHELLFISH or shellfish products.	""	0	#FFFFFF
D000067251	C23.550.291.937.500	Symptom Flare Up	A transient exacerbation of symptoms of an existing disease or condition.	""	0	#FFFFFF
D000067329	C18.654.726.750.500.650|C23.888.144.699.500.250	Obesity, Metabolically Benign	A sub-PHENOTYPE of obese individuals who have a risk for CARDIOVASCULAR DISEASES between that of healthy individuals with normal weight and unhealthy individuals with obesity.	""	0	#FFFFFF
D000067390	C26.212	Cold Injury	A physical injury caused by exposure of the body to extremely low ambient temperatures that may lead to loss of body parts, or in extreme cases, death. Examples of cold injury are FROSTBITE and CHILBLAINS.	""	0	#FFFFFF
D000067398	C26.946	War-Related Injuries	WOUNDS and INJURIES and PSYCHOLOGICAL TRAUMA sustained during WAR.	""	0	#FFFFFF
D000067562	C23.550.291.883	Late Onset Disorders	Pathological conditions (Disorder, SYNDROME, or DISEASE) whose SIGNS AND SYMPTOMS manifest late in the life of an individual.	""	0	#FFFFFF
D000068376	C23.888.369.500.500	Compassion Fatigue	Emotional distress caused by repeated or prolonged expression of compassion or empathy. It may occur in individuals working in care giving professions.	""	0	#FFFFFF
D000069076	C26.404.280|C26.640.500	Fractures, Multiple	Injuries involving the breaking of either several bones or one bone in two or more places.	""	0	#FFFFFF
D000069279	C10.228.140.490.125	Drug Resistant Epilepsy	Epileptic condition in which adequate trials of two tolerated and appropriately chosen and used ANTIEPILEPTIC DRUGS schedules to achieve sustained seizure freedom failed.	""	0	#FFFFFF
D000069281	C10.228.140.617.738.275.500|C19.700.419.500|C20.111.273	Autoimmune Hypophysitis	Immune-mediated inflammation of the PITUITARY GLAND often associated with other autoimmune diseases (e.g., HASHIMOTO DISEASE; GRAVES DISEASE; and ADDISON DISEASE).	""	0	#FFFFFF
D000069282	C11.496.221.500	Canaliculitis	Inflammation and infection of the lacrimal canaliculus area in the LACRIMAL APPARATUS.	""	0	#FFFFFF
D000069290	C23.300.707.945|C23.550.767.500	Incisional Hernia	Protrusion of tissue at or near the site of an incision from a previous surgery.	""	0	#FFFFFF
D000069293	C04.557.386.480.150.585.500|C15.604.515.569.480.150.585.500|C20.683.515.761.480.150.585.500	Plasmablastic Lymphoma	Malignant lymphoma composed of large B lymphoid cells which have the immunophenotype of plasma cells and a predilection for the ORAL CAVITY.	""	0	#FFFFFF
D000069295	C04.557.470.200.588	Mammary Analogue Secretory Carcinoma	A malignant neoplasm of epithelial cells of the SALIVARY GLANDS, with microcystic architecture, low-grade nuclei, and granular vacuolated cytoplasm.	""	0	#FFFFFF
D000069316	C17.800.030.150.500|C17.800.794.111.500	Acne Conglobata	Severe and chronic form of acne characterized by large, burrowing abscesses associated with disfigurement.	""	0	#FFFFFF
D000069337	C12.050.351.875.420|C12.200.706.445|C12.800.445|C16.131.939.445	Fused Kidney	Congenital fusion of two kidneys.	""	0	#FFFFFF
D000069451	C23.550.543	Long Term Adverse Effects	Persistent detrimental effects from treatment for a condition. Included are effects from surgery such as POSTOPERATIVE COMPLICATIONS, and from DRUG THERAPY, such as CHEMICALLY INDUCED DISORDERS, or other THERAPEUTICS. Failure to attain a desired outcome from treatment for the condition is not considered an adverse effect.	""	0	#FFFFFF
D000069544	C01.207.399|C10.228.140.430.520|C10.228.228.399|C10.586.250.520	Infectious Encephalitis	Brain inflammation caused by an infectious agent.	""	0	#FFFFFF
D000069578	C01.936	Waterborne Diseases	Illnesses due to micro-organisms and chemicals in drinking water, those caused by organisms having part of their lifecycle in water or those with water-related vectors, and others spread by aerosols containing pathogens.	""	0	#FFFFFF
D000069584	C04.588.180.800|C17.800.090.500.682	Unilateral Breast Neoplasms	Tumors or cancer found specifically in one human BREAST, but not in both.	""	0	#FFFFFF
D000069836	C26.808.500	Degloving Injuries	Avulsions of the superficial tissues of SKIN and SUBCUTANEOUS TISSUE from the underlying FASCIA.	""	0	#FFFFFF
D000069856	C12.050.351.968.419.600.500.500|C12.050.351.968.967.249.500.500|C12.050.351.968.967.500.503.500|C12.200.777.419.600.500.500|C12.200.777.967.249.500.500|C12.200.777.967.500.503.500|C12.950.419.600.500.500|C12.950.967.249.500.500|C12.950.967.500.503.500|C23.300.175.850.550.500	Staghorn Calculi	Renal calculi with a characteristic shape like antlers of a deer, formed as it extends into multiple calices of the RENAL PELVIS. A large number of staghorn calculi as well as other URINARY CALCULI are composed of STRUVITE.	""	0	#FFFFFF
D000070558	C05.330.488.655|C05.330.495.681|C05.660.585.512.380.813|C16.131.621.585.512.500.681	Talipes	Deformity in which the foot is misaligned with respect to the TALUS in the ANKLE JOINT. While mostly congenital, as in CLUBFOOT, acquired deformities are included. Acquired talipedes are often associated with other foot deformities such as SYNDACTYLY and POLYDACTYLY.	""	0	#FFFFFF
D000070589	C05.330.488.655.500|C05.330.495.681.500|C05.660.585.512.380.813.500|C16.131.621.585.512.500.681.500	Talipes Cavus	A foot deformity in which the arch of the foot is high and often the heel adducted.	""	0	#FFFFFF
D000070591	C05.330.663	Metatarsal Valgus	A foot anomaly in which the forefoot is angled outward relative to the hindfoot.	""	0	#FFFFFF
D000070592	C05.330.711	Metatarsus Varus	A foot anomaly in which the forefoot (METATARSUS) is angled inward relative to the heel.	""	0	#FFFFFF
D000070598	C26.558.554.213	Anterior Cruciate Ligament Injuries	Sprain or tear injuries to the ANTERIOR CRUCIATE LIGAMENT of the knee.	""	0	#FFFFFF
D000070599	C26.803	Shoulder Injuries	Injuries involving the SHOULDERS and SHOULDER JOINT.	""	0	#FFFFFF
D000070600	C26.558.781	Tibial Meniscus Injuries	Injuries to the TIBIAL MENISCUS of the leg.	""	0	#FFFFFF
D000070603	C05.116.296	Coxa Magna	Deformity of the hip characterized by enlargement and deformation of the FEMUR HEAD and FEMUR NECK, often with associated changes in the ACETABULUM. These changes may be secondary to other diseases (e.g.  LEGG-PERTHES DISEASE; ARTHRITIS; HIP DISLOCATION, CONGENITAL) or TRAUMA.	""	0	#FFFFFF
D000070604	C05.116.099.370.894.909|C05.330.495.787|C05.660.585.512.380.875|C05.660.906.909|C16.131.621.585.512.500.787|C16.131.621.906.909	Tarsal Coalition	Congenital, complete or partial fusion of the TARSAL BONES of the foot. PES PLANUS is usually a feature.	""	0	#FFFFFF
D000070607	C05.360.500.500|C05.550.610.500|C10.668.829.600.375|C23.888.592.612.540.500|C23.888.592.612.664.275	Morton Neuroma	A nerve inflammation in the foot caused by chronic compression of the plantar nerve between the METATARSAL BONES.	""	0	#FFFFFF
D000070617	C26.599	Microtrauma, Physical	Small injuries caused by external force applied to the body including bones, muscles, nerves and tendons.	""	0	#FFFFFF
D000070624	C10.228.140.199.444.375|C10.900.300.087.235.375|C26.915.300.200.194.375|C26.974.250.500	Brain Contusion	A bruise of the brain from an impact of the skull.	""	0	#FFFFFF
D000070625	C10.228.140.199.388|C10.900.300.087.219|C26.915.300.200.188	Brain Injuries, Diffuse	Brain injuries occurring over a wide area instead of specific focal area.	""	0	#FFFFFF
D000070627	C10.228.140.199.444.500|C10.228.140.199.500.500|C10.574.250|C10.900.300.087.235.500|C10.900.300.087.250.500|C23.550.291.500.063.500.500|C26.915.300.200.194.500|C26.915.300.200.200.500	Chronic Traumatic Encephalopathy	Degenerative brain disease linked to repetitive brain trauma. Progressive symptoms may include MEMORY LOSS; AGGRESSION; or DEPRESSION.	""	0	#FFFFFF
D000070630	C05.550.518.288|C26.289.288	Diastasis, Muscle	Abnormal separation of muscles.	""	0	#FFFFFF
D000070631	C05.550.518.192|C26.289.192	Diastasis, Bone	Abnormal separation of bones, often from a LIGAMENT.	""	0	#FFFFFF
D000070636	C26.761.340|C26.803.063|C26.874.400	Rotator Cuff Injuries	Injuries to the ROTATOR CUFF of the shoulder joint.	""	0	#FFFFFF
D000070639	C05.651.869.435|C26.874.800.500	Elbow Tendinopathy	Inflammation (tendinitis) or degeneration (tendinosis) of the tendons of the elbow.	""	0	#FFFFFF
D000070642	C10.228.140.199.444|C10.900.300.087.235|C26.915.300.200.194	Brain Injuries, Traumatic	A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.	""	0	#FFFFFF
D000070656	C05.550.114.264.500|C05.550.354.250	Rotator Cuff Tear Arthropathy	Rapidly destructive shoulder joint and bone disease found mainly in elderly, and predominantly in women. It is characterized by SHOULDER PAIN; JOINT INSTABILITY; and the presence of crystalline CALCIUM PHOSPHATES in the SYNOVIAL FLUID. It is associated with ROTATOR CUFF INJURIES.	""	0	#FFFFFF
D000070657	C05.550.354	Crystal Arthropathies	Joint disorders that are characterized by accumulation of microcrystals in and around the joint including in the SYNOVIAL FLUID. They are classified according to the chemical nature of the crystals such as CALCIUM PYROPHOSPHATE; basic CALCIUM PHOSPHATES; and monosodium urate (see URIC ACID).	""	0	#FFFFFF
D000070676	C05.651.869.653|C26.874.800.750	Enthesopathy	A disorder occurring at the site of insertion of TENDONS or LIGAMENTS into bones or JOINT CAPSULES.	""	0	#FFFFFF
D000070779	C04.557.450.565.380.690|C05.550.870.445|C05.651.869.762	Giant Cell Tumor of Tendon Sheath	A tumor arising in the SYNOVIAL MEMBRANE; SYNOVIAL BURSA; or TENDON sheath. It is characterized by OSTEOCLAST-like GIANT CELLS; FOAM CELLS; pigmented HEMOSIDERIN-laden MACROPHAGES and inflammatory infiltrate. It is classified either as diffuse or localized tenosynovitis.	""	0	#FFFFFF
D000070896	C26.404.625.500|C26.803.250.500	Bankart Lesions	An anterior capsulolabral injury associated with a tear of the anteroinferior GLENOID LABRUM.	""	0	#FFFFFF
D000071017	C10.228.590	Hyperekplexia	A neurological disorder characterized by an excessive startle reaction with ABNORMAL REFLEX;  MYOCLONIC JERKS; and MUSCLE HYPERTONIA.	""	0	#FFFFFF
D000071056	C06.198.025|C16.131.314.047	Anorectal Malformations	Congenital defects in the anus and the rectum often involving the urinary and genital tracts.	""	0	#FFFFFF
D000071057	C10.228.662.262.500.500|C10.597.350.275.500|C23.888.592.350.275.500	Tardive Dyskinesia	Drug-related movement disorder characterized by uncontrollable movements in certain muscles. It is associated with a long-term exposure to certain neuroleptic medications (e.g., METOCLOPRAMIDE).	""	0	#FFFFFF
D000071064	C23.888.369.500.250	Alert Fatigue, Health Personnel	Mental fatigue experienced by health care providers who encounter numerous alerts and reminders from the use of CLINICAL DECISION SUPPORT SYSTEMS. As the numbers of alerts and reminders designed to provide meaningful assistance to the patient care process increases, many health personnel may ignore them.	""	0	#FFFFFF
D000071067	C01.748.610.608|C08.381.677.608|C08.730.610.608	Pneumonia, Necrotizing	Severe complication of pneumonia characterized by liquefaction of lung tissue.	""	0	#FFFFFF
D000071069	C23.550.291.500.500	Multiple Chronic Conditions	Two or more concurrent chronic physical, mental, or behavioral health problems in an individual.	""	0	#FFFFFF
D000071070	C16.320.298|C17.800.463.375|C18.452.584.718.625	Familial Multiple Lipomatosis	A rare autosomal disorder characterized by numerous encapsulated lipomas on the trunk and extremities. The lipomas are usually not painful but can cause pain when growing. In rare cases, one lipoma can become painful and progress to multiple painful lipomas; it is then referred to as Dercum's Disease Type III	""	0	#FFFFFF
D000071071	C14.907.055.817	Microaneurysm	Aneurysm of the MICROVASCULATURE. Charcot–Bouchard aneurysms are aneurysms of the brain vasculature which is a common cause of CEREBRAL HEMORRHAGE. Retinal microaneurysm is an early diagnostic sign of DIABETIC RETINOPATHY.	""	0	#FFFFFF
D000071072	C10.228.140.021	Acute Febrile Encephalopathy	Acute onset of fever accompanied by seizures, cerebral inflammation and a change in mental status (e.g., confusion, disorientation, and coma).	""	0	#FFFFFF
D000071074	C01.757.580|C16.614.627|C23.550.470.790.500.470	Neonatal Sepsis	Blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age.	""	0	#FFFFFF
D000071075	C10.668.829.860	Small Fiber Neuropathy	Disorder of the peripheral nerves that primarily impair small nerve fibers. The affected small nerve fibers include myelinated A-delta fibers (see A FIBERS) and unmyelinated C FIBERS. Because these small fibers innervate skin and help control autonomic function, their neuropathy presents with neuropathic pain, reduced thermal and pain sensitivity, and autonomic dysfunction (e.g. abnormal sweating or facial flushing). Small fiber neuropathy can be idiopathic or associated with underlying diseases (e.g., AMYLOIDOSIS; DIABETES MELLITUS; SARCOIDOSIS; or VASCULITIS).	""	0	#FFFFFF
D000071078	C14.907.798	Stenosis, Pulmonary Vein	Narrowing of the PULMONARY VEIN.	""	0	#FFFFFF
D000071079	C14.907.137.825	Stenosis, Pulmonary Artery	Narrowing of the PULMONARY ARTERIES.	""	0	#FFFFFF
D000071243	C01.920.500.990|C01.925.081.990|C01.925.782.350.250.990	Zika Virus Infection	A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	""	0	#FFFFFF
D000071257	C10.597.606.337.500.500|C23.550.767.181|C23.888.592.604.339.500.500	Emergence Delirium	A form of DELIRIUM which occurs after GENERAL ANESTHESIA.	""	0	#FFFFFF
D000071297	C01.221.250.875.044|C01.221.812.640.400.044|C01.778.640.400.044|C01.925.782.815.616.400.044|C01.925.813.400.044|C12.100.937.640.400.044|C20.673.480.044	Acute Retroviral Syndrome	Early stage of HIV infection. Symptoms resemble INFLUENZA or INFECTIOUS MONONUCLEOSIS.	""	0	#FFFFFF
D000071298	C23.550.260.127	Body Remains	The physical entity of a deceased human or animal.	""	0	#FFFFFF
D000071378	C05.330.488.050	Bunion	Abnormal swelling of the inner aspect of the first metatarsal head affecting the first METATARSOPHALANGEAL JOINT.	""	0	#FFFFFF
D000071380	C04.557.450.565.590.340.705|C05.360.375|C05.651.197.369|C17.300.349|C17.800.321.063	Fibromatosis, Plantar	A fibromatosis of the plantar fascia characterized by thickening of the fibrous bands on the plantar aponeurosis in the sole of the foot and toes.	""	0	#FFFFFF
D000071562	C26.404.038	Fractures, Avulsion	Tearing away of the CORTICAL BONE fragment at the location of a strong ligament or tendon attachment. The bone fragment detachment site often occurs near a soft site (e.g., GROWTH PLATE) at the base where LIGAMENTS; TENDONS; or JOINT CAPSULES attach. In younger patients it is most often caused by a sudden forceful pull on a tendon in the opposite direction of the bone movement. In the elderly it is associated with osteoporotic INSUFFICIENCY FRACTURES.	""	0	#FFFFFF
D000071576	C26.257	Crush Injuries	Excessive compression of parts of the body that causes muscle swelling, fracture, and/or neurological disturbances in the affected areas. Crush injury with systemic manifestations is referred to as CRUSH SYNDROME.	""	0	#FFFFFF
D000071697	C23.888.885.281	Cellulite	Skin lumpiness or skin surface dimpling often seen on the thighs, buttocks and abdomen. It is due to protrusion of SUBCUTANEOUS FAT into the DERMIS layer of skin.	""	0	#FFFFFF
D000071698	C18.452.394.750.714|C19.246.656|C20.111.576	Latent Autoimmune Diabetes in Adults	Autoimmune diabetes in adults with slowly progressive PANCREATIC BETA CELL failure and the presence of circulating autoantibodies to PANCREATIC ISLETS cell antigens.	""	0	#FFFFFF
D000071699	C09.218.568.900.442|C10.597.057|C23.888.592.057	Bilateral Vestibulopathy	Impairment of the vestibular function of both inner ears which can cause difficulties with balance, gait, VERTIGO, and visual blurring.	""	0	#FFFFFF
D000071700	C11.270.152|C11.768.585.658.250|C16.320.290.152	Cone-Rod Dystrophies	Genetically heterogeneous and sometimes syndromic (e.g., BARDET BIEDL SYNDROME; and SPINOCEREBELLAR ATAXIA TYPE 7) retinopathies with initial RETINAL CONE involvement. They are characterized by decreased VISUAL ACUITY; COLOR VISION DEFECTS; progressive loss of peripheral vision and night blindness.	""	0	#FFFFFF
D000071896	C23.888.541	Medically Unexplained Symptoms	Persistent health symptoms which remain unexplained after a complete medical evaluation. A cluster of symptoms that consistently appear together but without a known cause are referred to as a MEDICALLY UNEXPLAINED SYNDROME (MUS).	""	0	#FFFFFF
D000071956	C26.891.375.750|C26.974.250.875	Myocardial Contusions	Bruise to the heart muscle due to blunt thoracic trauma.	""	0	#FFFFFF
D000071960	C04.557.470.200.240.187|C04.588.180.130|C17.800.090.500.130	Breast Carcinoma In Situ	A condition in which abnormal cells have not spread outside the duct, lobule, or nipple to other tissues of the breast. There are 3 types of breast carcinoma in situ: DUCTAL CARCINOMA IN SITU; LOBULAR CARCINOMA IN SITU; and PAGET DISEASE OF THE NIPPLE.	""	0	#FFFFFF
D000072039	C05.550.518.336|C26.289.336|C26.404.026	Fracture Dislocation	Fracture of a bone near an articulation with concomitant dislocation of that joint.	""	0	#FFFFFF
D000072042	C05.550.518.336.875|C26.289.336.875|C26.404.026.500	Salter-Harris Fractures	Fractures involving a GROWTH PLATE.	""	0	#FFFFFF
D000072281	C15.604.338	Lymphadenopathy	Disease of LYMPH NODES which are abnormal in size, number or consistency.	""	0	#FFFFFF
D000072656	C15.604.496.160|C23.550.767.082	Breast Cancer Lymphedema	Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical treatment (e.g., MASTECTOMY) or radiation treatment of breast cancer.	""	0	#FFFFFF
D000072657	C14.280.647.500.875|C14.907.585.500.875|C23.550.513.355.750.875|C23.550.717.489.750.875	ST Elevation Myocardial Infarction	A clinical syndrome defined by MYOCARDIAL ISCHEMIA symptoms; persistent elevation in the ST segments of the ELECTROCARDIOGRAM; and release of BIOMARKERS of myocardial NECROSIS (e.g., elevated TROPONIN levels). ST segment elevation in the ECG is often used in determining the treatment protocol (see also NON-ST ELEVATION MYOCARDIAL INFARCTION).	""	0	#FFFFFF
D000072658	C14.280.647.500.469|C14.907.585.500.656|C23.550.513.355.750.469|C23.550.717.489.750.469	Non-ST Elevated Myocardial Infarction	A myocardial infarction that does not produce elevations in the ST segments of the ELECTROCARDIOGRAM. ST segment elevation of the ECG is often used in determining the treatment protocol (see also ST Elevation Myocardial Infarction).	""	0	#FFFFFF
D000072659	C10.228.140.617.738.275|C19.700.419	Hypophysitis	Inflammation of the PITUITARY GLAND.	""	0	#FFFFFF
D000072660	C12.100.500.430.877|C12.100.750.700.877|C12.200.294.430.877	Teratozoospermia	Conditions in which sperm show abnormal morphology.	""	0	#FFFFFF
D000072661	C16.131.077.245|C16.320.184	Ciliopathies	Genetic disorders caused by defects in genes related to the primary CILIUM; BASAL BODY; or CENTROSOME. Primary features may include obesity, SKELETAL DYSPLASIA; POLYDACTYLY and malformations that primarily involve the liver, eye or kidneys.	""	0	#FFFFFF
D000072662	C23.149.625	Margins of Excision	The edges of tissue removed in a surgery for assessment of the effectiveness of a surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. When the margin is negative or not involved by tumor (e.g., CANCER) it suggests all of the tumor has been removed by the surgery.	""	0	#FFFFFF
D000072663	C23.300.940	Spontaneous Perforation	A pathological hole in an organ, blood vessel or other soft part of the body, occurring in the absence of external force.	""	0	#FFFFFF
D000072676	C07.160	Ankyloglossia	A severe congenital restriction of TONGUE movement, resulting from fusion or adherence of the tongue to the floor of the mouth. In partial ankyloglossia (tongue-tie) the LINGUAL FRENUM is abnormally short, or is attached too close to the tip of the tongue. OMIM: 106280	""	0	#FFFFFF
D000072716	C23.888.592.612.212	Cancer Pain	Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during NEOPLASM growth, tissue invasion, and METASTASIS.	""	0	#FFFFFF
D000072717	C23.300.955	Tertiary Lymphoid Structures	Aggregates of immune cells formed near the sites of chronically inflamed, infected, or tumorous tissues.	""	0	#FFFFFF
D000072736	C25.100.844	Propofol Infusion Syndrome	Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE.	""	0	#FFFFFF
D000072742	C01.150.703.492	Invasive Fungal Infections	Mycoses which manifest as infections of deep tissue or blood.	""	0	#FFFFFF
D000072836	C26.859	Surgical Wound	An incision made during a surgical procedure.	""	0	#FFFFFF
D000072837	C23.550.210.310	Chromothripsis	Massive number of chromosomal rearrangements and shattering that occurs in cancer cells. The breakpoints are located within one chromosome or chromosome arm.	""	0	#FFFFFF
D000073296	C23.550.291.898	Noncommunicable Diseases	Diseases which are typically non-infectious in origin and do not transmit from an affected individual to others. The four main types of noncommunicable diseases are CARDIOVASCULAR DISEASES (e.g., heart attacks and stroke), CANCER, chronic respiratory diseases (e.g., CHRONIC OBSTRUCTIVE PULMONARY DISEASE and ASTHMA) and DIABETES MELLITUS.	""	0	#FFFFFF
D000073376	C10.228.140.490.493	Epileptic Syndromes	EPILEPTIC SEIZURES that are of similar type and age of onset and have other similar features (e.g., clinical course, EEG findings, genetic association and neuropathology).	""	0	#FFFFFF
D000073397	C24.580	Occupational Stress	Adverse psychological and behavioral reactions caused by the pressures and demands of employers or clients or other factors, such as the physical environment of the workplace, WORKPLACE VIOLENCE; or WORKPLACE BULLYING.	""	0	#FFFFFF
D000073436	C23.300.818	Microvascular Rarefaction	The reduction in density of the MICROVASCULATURE.	""	0	#FFFFFF
D000073496	C23.550.359	Frailty	A state of increased vulnerability to stressors, following declines in function and reserves across multiple physiologic systems, characterized by MUSCLE WEAKNESS; FATIGUE; slowed motor performance; low physical activity; and unintentional weight loss.	""	0	#FFFFFF
D000073605	C01.150.252.400.789.725.400|C01.920.930.887	Spotted Fever Group Rickettsiosis	A group of arthropod-borne diseases caused by spotted fever bio-group members of RICKETTSIA. They are characterized by fever, headache, and petechial (spotted) rash.	""	0	#FFFFFF
D000073617	C08.381.520.500.500|C15.378.962.500|C20.920.500	Transfusion-Related Acute Lung Injury	A rare but serious transfusion-related reaction in which fluid builds up in the lungs unrelated to excessively high infusion rate and/or volume (TRANSFUSION-ASSOCIATED CIRCULATORY OVERLOAD). Signs of Transfusion-Related Acute Lung Injury include pulmonary secretions; hypotension; fever; DYSPNEA; TACHYPNEA; TACHYCARDIA; and CYANOSIS.	""	0	#FFFFFF
D000073618	C01.925.256.466.930	Varicella Zoster Virus Infection	Infection caused by HUMAN HERPES VIRUS 3 (e.g., CHICKENPOX and HERPES ZOSTER).	""	0	#FFFFFF
D000073818	C23.888.592.612.860	Pain, Procedural	Pain associated with examination, treatment or procedures.	""	0	#FFFFFF
D000073839	C10.597.606.360.835|C14.240.400.970|C14.280.400.970|C16.131.077.919|C16.131.240.400.965|C16.131.260.923|C16.320.180.923	Trisomy 13 Syndrome	A chromosome disorder associated with TRISOMY of all or part of CHROMOSOME 13. Clinical manifestations include CONGENITAL HEART DEFECTS (e.g., PATENT DUCTUS ARTERIOSUS), facial malformations (e.g., CLEFT LIP; CLEFT PALATE; COLOBOMA; MICROPHTHALMIA); HYPOTONIA, digit malformations (e.g., POLYDACTYLY or SYNDACTYLY), and SEIZURES and severe INTELLECTUAL DISABILITY associated with NERVOUS SYSTEM MALFORMATIONS.	""	0	#FFFFFF
D000073842	C14.240.400.975|C14.280.400.975|C16.131.077.929|C16.131.240.400.968|C16.131.260.932|C16.320.180.932	Trisomy 18 Syndrome	A chromosome disorder associated with TRISOMY of all or part of CHROMOSOME 18. Clinical manifestations include INTRAUTERINE GROWTH RETARDATION; CLEFT PALATE; CONGENITAL HEART DEFECTS; MICROCEPHALY; MICROGNATHIA and clenched fists with overlapping fingers. Most affected fetuses do not survive to birth. Those who survive through their first year often have severe INTELLECTUAL DISABILITY.	""	0	#FFFFFF
D000073872	C14.240.850.992|C14.907.109.239.825|C16.131.240.850.984	Vascular Ring	Congenital vascular malformation in which the AORTA arch and its branches encircle the TRACHEA and ESOPHAGUS. Signs and symptoms include DYSPNEA; RESPIRATORY SOUNDS, especially with eating, DYSPHAGIA, persistent cough, and GASTROESOPHAGEAL REFLUX or may be asymptomatic. Two most common types are double aortic arch and right aortic arch. It may be associated with other anomalies (e.g., DIGEORGE SYNDROME).	""	0	#FFFFFF
D000073923	C23.888.821.387	Food Intolerance	Digestive system disorder where a particular food irritates the digestive tract or cannot be properly digested (i.e., due to a lack of a digestive enzyme). It differs from FOOD HYPERSENSITIVITY which is an immune system disorder, usually due to specific proteins in food.  http://my.clevelandclinic.org/health/articles/problem-foods-is-it-an-allergy-or-intolerance.	""	0	#FFFFFF
D000074009	C04.557.470.035.175.900|C04.557.470.550.175.900	Tubular Sweat Gland Adenomas	Various tubular forms of benign tumors of the SWEAT GLAND with glandular differentiation. Common types include syringocystadenoma papilliferum of the head and neck, and hidradenoma papilliferum of the vulva area. Hidradenoma papilliferum may be derived from mammary-like glands of the vulva.	""	0	#FFFFFF
D000074021	C14.280.067.558.430|C14.280.123.500.430|C23.550.073.425.270	Interatrial Block	Impaired or delayed impulse conduction between the right and left HEART ATRIA. Advanced interatrial blocks are often associated with arrhythmias (e.g., ATRIAL FLUTTER; and ATRIAL FIBRILLATION), direct conduction block via the Bachmann's bundle and concomitant left atrial enlargement. Syndrome of advanced interatrial block associated with SUPRAVENTRICULAR TACHYCARDIA is referred to as Bayes syndrome.	""	0	#FFFFFF
D000074042	C10.228.140.300.535.200.600|C14.907.253.573.200.600|C23.550.414.913.100.600	Cerebral Intraventricular Hemorrhage	Bleeding within the CEREBRAL VENTRICLES. It is associated with intraventricular trauma, aneurysm, vascular malformations, hypertension and in VERY LOW BIRTH WEIGHT infants.	""	0	#FFFFFF
D000074079	C17.300.849|C20.111.904	Undifferentiated Connective Tissue Diseases	Diseases that exhibit signs and symptoms suggestive of a connective tissue disease that do not fulfill clinical or diagnostic criteria for any one defined disease but overlap with criteria of multiple such diseases. Commonly overlapping diseases include systemic autoimmune connective tissue diseases such as RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; and SYSTEMIC SCLEROSIS.	""	0	#FFFFFF
D000074270	C06.405.469.531.788	Meconium Ileus	Intestinal obstruction caused by congealed MECONIUM in the distal ILEUM and CECUM. It presents shortly after birth as a failure to pass meconium and frequently occurs in infants with CYSTIC FIBROSIS.	""	0	#FFFFFF
D000074607	C25.775.643.500.800	Opium Dependence	Strong physiological and emotional dependence on OPIUM.	""	0	#FFFFFF
D000074723	C04.697.850|C23.550.727.850	Oncogene Addiction	The dependence of tumor cells on a single oncogenic pathway or protein for their continued proliferation and survival.	""	0	#FFFFFF
D000074742	C06.198.929|C14.240.850.922|C14.907.137.527|C16.131.240.850.898	Median Arcuate Ligament Syndrome	Compression of the CELIAC ARTERY by the median arcuate ligament, a fibrous band of the DIAPHRAGM, causing abdominal pain after eating and weight loss. OMIM: 116870	""	0	#FFFFFF
D000074924	C20.543.480.370.572	Nut and Peanut Hypersensitivity	Allergic reaction to tree nuts and peanuts, including other LEGUMES, that is triggered by the immune system. It includes co-sensitization to other food (e.g., sesame seed).	""	0	#FFFFFF
D000074962	C14.280.647.375|C14.907.585.375|C20.543.560	Kounis Syndrome	A disorder of cardiac function secondary to hypersensitivity reactions. It is characterized by coexistence of acute coronary syndromes and cardiac MAST CELL and PLATELET ACTIVATION. It may be induced by exposure to drugs (e.g., antibiotics, anesthetics, contrast media), food, and environmental triggers (e.g., insect bites and stings, poison ivy).	""	0	#FFFFFF
D000075067	C25.775.814	Substance Abuse, Oral	Abuse, overuse, or misuse of a substance by ingestion.	""	0	#FFFFFF
D000075122	C04.834.794|C15.378.147.542.820|C15.378.147.780.838|C20.683.460.820|C20.683.780.838	Smoldering Multiple Myeloma	An asymptomatic and slow-growing PLASMA CELL dyscrasia characterized by presence of MYELOMA PROTEINS and clonal bone marrow plasma cells without end-organ damage (e.g., renal impairment). It is distinguished from MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE by a much higher risk of progression to symptomatic MULTIPLE MYELOMA.	""	0	#FFFFFF
D000075222	C14.907.489.165	Essential Hypertension	Hypertension that occurs without known cause, or preexisting renal disease. Associated polymorphisms for a number of genes have been identified, including AGT, GNB3, and ECE1. OMIM: 145500	""	0	#FFFFFF
D000075224	C14.280.123	Cardiac Conduction System Disease	Diseases characterized by pathological irregularities in the HEART CONDUCTION SYSTEM. They may be associated with other heart diseases and syndromes (e.g., BRUGADA SYNDROME; NEUROMUSCULAR DISEASE, HEART BLOCKS), isolated or may result from injuries. You can have a conduction disorder without having an arrhythmia, but some arrhythmias arise from conduction disorders. OMIM: 601144.	""	0	#FFFFFF
D000075262	C19.053.500.263.500	Hypoadrenocorticism, Familial	Hereditary forms of Addison disease that may exhibit autosomal recessive or X-linked  inheritance. They are characterized by severe neurological symptoms, APNEA;  and death in infancy. OMIM: 240200	""	0	#FFFFFF
D000075322	C25.723.522	Heavy Metal Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of HEAVY METALS. Acute and chronic exposures can cause ANEMIA; KIDNEY and LIVER damage; PULMONARY EDEMA; MEMORY LOSS and behavioral changes; bone deformities in children; and MISCARRIAGE or PREMATURE LABOR in pregnant women.	""	0	#FFFFFF
D000075363	C04.557.595.250|C18.452.845.500.550|C20.683.515.507|C20.683.780.565	Immunoglobulin Light-chain Amyloidosis	A nonproliferative disorder of the PLASMA CELL characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.	""	0	#FFFFFF
D000075529	C12.050.351.875.846|C12.200.706.846|C12.800.846|C23.300.925	Solitary Kidney	Either a single or a single functioning kidney due to NEPHRECTOMY, birth defects or other kidney diseases.	""	0	#FFFFFF
D000075562	C10.597.606.762.300.500|C23.888.592.604.764.300.500	Charles Bonnet Syndrome	Repetitive visual hallucinations experienced mostly by elderly with diminished visual acuity or visual field loss, with awareness of the fictional nature of their hallucinations. It is not associated with delusions and other sensory hallucinations.	""	0	#FFFFFF
D000075662	C23.550.340.500|C25.100.781	Injection Site Reaction	Adverse reactions that occur initially at the site of injection or infusion. Milder type is confined to a local allergic flare reaction. A more severe reaction is caused by extravasation of VESICANTS from the blood vessel at the site of injection and can cause damage to the surrounding tissue. In tumor flare reaction symptoms involve well beyond the injection site such as an increase in the tumor size and tumor markers levels, bone pain, and HYPERCALCEMIA.	""	0	#FFFFFF
D000075902	C23.550.291.656.350	Clinical Deterioration	A critical disease progression, often measured by a set of clinical parameters, which activates HOSPITAL RAPID RESPONSE TEAM.	""	0	#FFFFFF
D000076042	C10.597.606.525.400.500|C10.720.112.100.250|C23.888.592.604.529.400.500|C25.723.705.150.100.250|C25.775.100.087.193.100.250	Alcoholic Korsakoff Syndrome	A neurological disorder characterized by inattentiveness and the inability to form short term memories. It is caused by THIAMINE DEFICIENCY due to chronic ALCOHOLISM.	""	0	#FFFFFF
D000076082	C23.888.914	Travel-Related Illness	Health problems associated with TRAVEL.	""	0	#FFFFFF
D000076263	C01.221.625|C23.550.291.531.875	Communicable Diseases, Imported	Infectious diseases originating in one geographically delineated ecosystem that are carried (by travel or immigration) to another geographically delineated ecosystem by an infected individual, animal, or disease vector.	""	0	#FFFFFF
D000076385	C06.405.205.282	Diverticular Diseases	Diseases of the DIVERTICULUM often due to infection and/or inflammation (DIVERTICULITIS).	""	0	#FFFFFF
D000076984	C10.668.829.100.750|C16.614.131.294|C26.141.294	Neonatal Brachial Plexus Palsy	Perinatal nerve injury involving the BRACHIAL PLEXUS involving a weak or paralyzed upper extremity.	""	0	#FFFFFF
D000077162	C10.551.568	Neurolymphomatosis	Infiltration of the nervous system by malignant lymphoma cells.	""	0	#FFFFFF
D000077192	C04.557.470.200.025.022|C04.588.894.797.520.055	Adenocarcinoma of Lung	A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.	""	0	#FFFFFF
D000077195	C04.557.470.200.400.565|C04.588.443.177	Squamous Cell Carcinoma of Head and Neck	The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.	""	0	#FFFFFF
D000077207	C04.557.450.565.280.140|C04.557.450.795.300.140	Chondrosarcoma, Clear Cell	A chondrosarcoma of adolescence to old age of the proximal EPIPHYSES of long bones. It has variably clear cytoplasm of the mostly neoplastic CHONDROCYTES with little intervening matrix.	""	0	#FFFFFF
D000077216	C04.557.470.200.295|C04.588.322.455.199|C12.050.351.500.056.630.705.350|C12.050.351.937.418.685.350|C12.100.250.056.630.705.350|C12.900.418.685.350|C19.344.410.199|C19.391.630.705.350	Carcinoma, Ovarian Epithelial	A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.	""	0	#FFFFFF
D000077260	C23.888.900	Sleepiness	Compelling urge to sleep.	""	0	#FFFFFF
D000077273	C04.557.470.200.025.085.612|C04.588.322.894.400|C04.588.443.915.400|C19.344.894.400|C19.874.788.400	Thyroid Cancer, Papillary	An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.	""	0	#FFFFFF
D000077274	C04.557.470.200.623|C04.588.443.665.710.650.500|C07.550.350.650.500|C07.550.745.650.500|C09.647.710.650.500|C09.775.350.650.500|C09.775.549.650.500	Nasopharyngeal Carcinoma	A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.	""	0	#FFFFFF
D000077275	C05.116.099.708.375.286	Craniofacial Fibrous Dysplasia	Mostly benign fibro-osseous proliferation of the facial bones and skull. It can be either monostotic (localized to a single bone) or polyostotic (localized to more than one bone) type.	""	0	#FFFFFF
D000077277	C04.557.470.200.400.330|C04.557.470.700.400.565|C04.588.274.476.205.500|C04.588.443.353.500|C06.301.371.205.500|C06.405.117.430.500|C06.405.249.205.500	Esophageal Squamous Cell Carcinoma	A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.	""	0	#FFFFFF
D000077295	C12.050.351.968.829.867|C12.200.777.829.893|C12.950.829.867|C23.888.942.343.790	Urinary Bladder, Underactive	Symptom of underactive detrusor muscle of the URINARY BLADDER that contracts with abnormally reduced strength or duration resulting in an incomplete and/or prolonged bladder emptying.	""	0	#FFFFFF
D000077299	C01.248.250|C01.748.610.300|C08.381.677.300|C08.730.610.300|C23.550.291.875.500.500	Healthcare-Associated Pneumonia	Infection of the lung often accompanied by inflammation that is acquired through an interaction within a healthcare institution often through a therapeutic experience (e.g., use of catheters or ventilators).	""	0	#FFFFFF
D000077342	C01.150.252.400.536.850|C01.150.252.400.794.352.250.850|C01.920.930.513.850|C23.550.291.500.844	Post-Lyme Disease Syndrome	A condition caused by long-lasting and ongoing infection with the spirochete Borrelia burgdorferi resulting in progressive inflammatory neurologic, neuromuscular, and dermatologic manifestations including ENCEPHALITIS; MYELITIS; acrodermatitis chronica atrophicans; and ARTHRITIS.	""	0	#FFFFFF
D000077428	C15.378.190.625.265|C16.320.314	GATA2 Deficiency	A rare disorder of the immune system with wide-ranging effects which include GATA2 Transcription Factor dysfunction, immunodeficiency, myelodysplastic syndrome (ineffective blood cell production), lung disease, and problems of the vascular and lymphatic system.	""	0	#FFFFFF
D000077684	C10.668.829.550.350|C10.668.829.800.750.150	Cauda Equina Syndrome	Compressive lesion affecting the nerve roots of the CAUDA EQUINA (e.g., compression, herniation, inflammation, rupture, or stenosis), which controls the function of the bladder and bowel. Symptoms may include neurological dysfunction of bladder or bowels, loss of sexual sensation and altered sensation or paralysis in the lower extremities.	""	0	#FFFFFF
D000077733	C20.111.572	Immunoglobulin G4-Related Disease	A spectrum of systemic autoimmune diseases in which IMMUNOGLOBULIN G4 plays a pathophysiologic role. It can affect multiple organs in highly variable presentations, characterized by inflammatory lesions composed of IgG4-positive PLASMA CELLS, further infiltrated by T helper cells (T-LYMPHOCYTES, HELPER-INDUCER) when linked to progressive FIBROSIS and eventual organ damage.	""	0	#FFFFFF
D000077765	C11.270.151|C11.768.216	Cone Dystrophy	A general term which describes a group of rare eye disorders that affect the cone cells of the RETINA. Cone dystrophy can cause a variety of symptoms including decreased visual clarity or acuity when looking straight ahead (central vision), a reduced ability to see colors, and an increased sensitivity to light (PHOTOPHOBIA).	""	0	#FFFFFF
D000077777	C04.557.450.565.545|C04.557.645.380.500|C17.300.680.770	Myopericytoma	Rare myofibroma-like perivascular soft tissue tumor, usually benign, characterized by concentric perivascular proliferation.	""	0	#FFFFFF
D000077779	C04.557.470.615.665|C04.588.274.761.875|C04.588.322.475.875|C06.301.761.875|C06.689.667.812|C19.344.421.875	Pancreatic Intraductal Neoplasms	EPITHELIAL NEOPLASMS with pancreatic ductal differentiation that arise from the EXOCRINE PANCREAS and grow mostly within the PANCREATIC DUCTS. They are characterized by the presence of intraductal masses with mostly papillary growth pattern. Overt production of MUCIN within the pancreatic duct is associated with pancreatic intraductal papillary-mucinous neoplasm but not intraductal tubulopapillary neoplasm.	""	0	#FFFFFF
D000077962	C23.888.144.243.463	Body-Weight Trajectory	A general pattern of body weight gain or loss over many years. Weight change trajectory is influenced by several determinants in children and adults.	""	0	#FFFFFF
D000078064	C23.888.144.243.926.500	Gestational Weight Gain	Increase in body weight of the mother during the course of her PREGNANCY.	""	0	#FFFFFF
D000079262	C12.050.703.417|C18.654.726.750.500.633|C23.888.144.699.500.125	Obesity, Maternal	BODY MASS INDEX in PREGNANT WOMEN that is excessively above the recommended cut-off.	""	0	#FFFFFF
D000079263	C01.918	Vaccine-Preventable Diseases	Diseases for which vaccines exist that can confer partial or complete protection. (World Health Organization vaccine-safety-training.org)	""	0	#FFFFFF
D000079426	C01.920	Vector Borne Diseases	Infectious diseases transmitted by DISEASE VECTORS.	""	0	#FFFFFF
D000079524	C25.775.643	Narcotic-Related Disorders	Disorders related to or resulting from abuse or misuse of NARCOTICS.	""	0	#FFFFFF
D000079562	C06.405.609	Rumination Syndrome	A gastrointestinal disorder characterized by repetitive and effortless regurgitation of ingested food from the stomach to the oral cavity in the early POSTPRANDIAL PERIOD. It is associated with functional gastrointestinal pathology (e.g., increased intra-gastric pressure) and psychiatric disorders (e.g., anxiety, depression). It is not limited to infants and distinct from GERD and VOMITING.	""	0	#FFFFFF
D000079689	C23.888.821.150.500|C25.775.643.250	Opioid-Induced Constipation	CONSTIPATION associated with the use of OPIOIDS.	""	0	#FFFFFF
D000079690	C23.550.767.831	Postoperative Cognitive Complications	COGNITIVE IMPAIRMENT or functional decline after a surgical procedure.	""	0	#FFFFFF
D000079822	C04.697.650.280|C23.550.727.650.280	Extranodal Extension	A penetration of LYMPH NODE metastatic cells through the nodal capsule into the perinodal fatty tissue used in a TUMOR STAGING system (the TNM staging system).	""	0	#FFFFFF
D000080038	C14.240.400.210.125|C14.280.400.210.125|C16.131.240.400.210.125	Anomalous Left Coronary Artery	Malformations of left CORONARY ARTERY where it is connected to the PULMONARY ARTERY instead of the AORTA.	""	0	#FFFFFF
D000080039	C14.240.400.990|C14.280.400.990|C16.131.240.400.975	Univentricular Heart	Rare congenital heart malformation with a single ventricle (HEART VENTRICLES) instead of the usual two.	""	0	#FFFFFF
D000080041	C14.240.400.915.150|C14.280.400.915.150|C16.131.240.400.915.150	Congenitally Corrected Transposition of the Great Arteries	A rare heart defect that occurs when the HEART VENTRICLES and attached valves, the MITRAL VALVE and the TRICUSPID VALVE are reversed so that the AORTA and the PULMONARY ARTERY are connected to the wrong ventricle. Although the heart valves and the two great arteries, the PULMONARY ARTERY and the AORTA are transposed, the blood flows to the correct place because the ventricles are also reversed and therefore corrects the transposition. It often occurs with other structural heart abnormalities.	""	0	#FFFFFF
D000080203	C08.381.483.652.500.500	Hamman-Rich Syndrome	Acute idiopathic interstitial pneumonitis characterized by diffuse PULMONARY ALVEOLI damage with uniform edematous connective tissue proliferation. It is often associated with extensive fibroblastic distortion of the lung parenchyma and leads to ADULT RESPIRATORY DISTRESS SYNDROME in later stages.	""	0	#FFFFFF
D000080222	C06.130.120.250.640|C06.198.964|C16.131.314.778	Pancreaticobiliary Maljunction	A group of anatomical variations in which the COMMON BILE DUCT and MAIN PANCREATIC DUCT are joined outside the duodenal wall often with abnormally long common channel rather than at the SPHINCTER OF ODDI.	""	0	#FFFFFF
D000080223	C17.800.862.945.533|C20.543.480.904.533|C23.550.291.500.360	Chronic Urticaria	Wheals (urticaria) and/or angioedema presented with daily symptoms lasting for more than 6 weeks. It may be classified into chronic spontaneous and chronic inducible urticaria depending on whether a specific trigger can be linked to the development of vascular reaction.	""	0	#FFFFFF
D000080311	C10.597.606.762.850	Synesthesia	The experience of involuntary sensory cross activation where the presentation of a particular stimulus elicits a secondary sensory-perceptual experience. It most commonly occurs in the association of color with linguistic stimuli such as letters, numbers, words, or music, but can also occur between other senses. Although synesthesia can be acquired or transient due to trauma or drug use, there is also a strong genetic component, with a prevalence of about 1 in 2,000 individuals and a female to male ratio of 6:1.	""	0	#FFFFFF
D000080322	C11.250.105.250|C11.941.160.241.250	Cyclodialysis Clefts	Finding of a separation of the CILIARY BODY in the SCLERAL SPUR region, creating aqueous outflow from the ANTERIOR CHAMBER into suprachoroidal space between the CHOROID and the SCLERA. Persistent cyclodialysis clefts may be associated with OCULAR HYPOTENSION and OPTIC DISC EDEMA.	""	0	#FFFFFF
D000080323	C11.250.105.500|C11.941.160.241.500	Uveal Effusion Syndrome	Rare disease characterized by suprachoroidal fluid accumulation between the CHOROID and the SCLERA, annular detachment of the CHOROID, often with secondary RETINAL DETACHMENT; OPTIC DISK EDEMA, and minimal signs of UVEITIS and INTRAOCULAR PRESSURE changes.	""	0	#FFFFFF
D000080324	C11.250.105|C11.941.160.241	Choroidal Effusions	Finding of fluid accumulation between the CHOROID and the SCLERA.	""	0	#FFFFFF
D000080343	C11.338.780	Meibomian Gland Dysfunction	A chronic dysfunction of MEIBOMIAN GLANDS characterized by altered tear film stability and function due to a decrease or alteration in lipid quality/content in meibum. It is often associated with evaporative-type DRY EYE SYNDROME.	""	0	#FFFFFF
D000080344	C10.292.700.463|C10.500.760|C11.270.588|C11.640.522|C16.131.666.763|C16.320.290.612	Optic Nerve Hypoplasia	A group of rare genetic disorders characterized by underdeveloped OPTIC NERVES, resulting in increased incidences of vision impairment, CONGENITAL NYSTAGMUS and STRABISMUS. It may be syndromic, and is often associated with CNS malformations.	""	0	#FFFFFF
D000080345	C11.250.345|C11.270.238|C11.768.337|C16.131.384.424|C16.320.290.352	Familial Exudative Vitreoretinopathies	A group of inherited disorders characterized by incomplete development of the retinal vasculature. Its severity can vary from complete blindness in infancy, to mild or no visual problems, where small areas of vascular defects are observable only by FLUORESCEIN ANGIOGRAPHY. Exudative vitreoretinopathy 1 is associated with mutations in the FZD4 gene.	""	0	#FFFFFF
D000080346	C11.768.346.500|C14.907.055.908|C14.907.489.815.500	Retinal Arterial Macroaneurysm	An acquired dilation of the retinal artery often associated with systemic HYPERTENSION.	""	0	#FFFFFF
D000080362	C11.270.872|C11.768.585.439.339|C16.320.290.724	Stargardt Disease	A juvenile-onset macular dystrophy characterized by progressive loss of VISUAL ACUITY with normal acuity in peripheral VISUAL FIELDS. Other associated clinical features may include LIPOFUSCIN fundus autofluorescence, atrophy of the RETINAL PIGMENT EPITHELIUM, loss of color vision, PHOTOPHOBIA and PARACENTRAL SCOTOMA. Germline mutations in the ABCA4 gene have been identified in recessive and dominant diseases.	""	0	#FFFFFF
D000080363	C11.941.879.780.900.650	White Dot Syndromes	A group of idiopathic multifocal posterior uveitis syndromes involving the CHOROID; RETINAL PIGMENT EPITHELIUM; and RETINA. They are characterized by multiple lesions of hypoautofluorescent dots in the FUNDUS OCULI and reduced VISUAL ACUITY. Several entities including BIRDSHOT CHORIORETINOPATHY are HLA-A ANTIGENS serotype A29 positive.	""	0	#FFFFFF
D000080364	C11.941.160.478.550|C11.941.879.780.900.300.489|C11.941.879.780.900.650.500	Multifocal Choroiditis	A multifocal uveitis syndrome involving the RETINAL PIGMENT EPITHELIUM and capillary layer of the CHOROID. It is characterized by chronic UVEITIS and multiple CHOROID lesions referred to as white dots, blurry vision, floaters, sensitivity to light, blind spots, and eye discomfort.	""	0	#FFFFFF
D000080365	C11.768.773.348.500|C11.941.160.478.400.500|C11.941.879.780.900.300.318.500|C11.941.879.780.900.650.250|C20.111.303	Birdshot Chorioretinopathy	A form of chorioretinitis characterized by multiple small, cream-colored LESIONS, symmetrically scattered mainly around the OPTIC DISK. These lesions are the most distinctive sign and often appear at the level of the RETINAL PIGMENT EPITHELIUM but, on occasion, suggest an even deeper infiltration and may ultimately lead to visual loss. An association with HLA-A29 antigen (see HLA-A ANTIGENS) has been observed in nearly all patients.	""	0	#FFFFFF
D000080422	C10.597.622.760.500|C10.668.416|C23.888.592.636.786.500	Locked-In Syndrome	Acquired neuromuscular disorder characterized by complete paralysis of voluntary muscles and lower CRANIAL NERVES except for limited voluntary eye movements. It is due to various cerebrospinal disconnections at or near the PONS and the POSTERIOR CRANIAL FOSSA, typically secondary to pontine hemorrhage or infarct. Because cognitive function is intact it is sometimes referred to as a pseudocoma state.	""	0	#FFFFFF
D000080424	C23.550.470.790.250|C23.550.835.900.356	Cytokine Release Syndrome	A severe immune reaction characterized by excessive release of CYTOKINES. Symptoms include DYSPNEA; FEVER; HEADACHE; HYPOTENSION; NAUSEA; RASH; TACHYCARDIA; HYPOXIA; HYPERFERRITINEMIA, and MULTIPLE ORGAN FAILURE. It is associated with viral infections, SEPSIS; AUTOIMMUNE DISEASES and a variety of factors used in IMMUNOTHERAPY.	""	0	#FFFFFF
D000080443	C04.557.465.625.600.380.185|C04.557.470.670.380.185|C04.557.580.625.600.380.185|C04.588.614.250.195.411.100.500|C10.228.140.211.500.100.500|C10.551.240.250.400.200.500	Diffuse Intrinsic Pontine Glioma	A rare, aggressive brain tumor that forms in the GLIAL CELLS in the PONS.	""	0	#FFFFFF
D000080445	C08.127.108.688|C08.381.495.108.500|C08.381.495.389.250|C08.674.095.688|C20.543.103|C23.550.291.500.875.500	Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome	Syndrome with clinical features of both ASTHMA and COPD.	""	0	#FFFFFF
D000080485	C10.228.140.490.746|C23.550.260.322.812	Sudden Unexpected Death in Epilepsy	Sudden death in a patient with EPILEPSY associated with SEIZURES and seizure-related symptoms (e.g., APNEA; HYPOXEMIA) without other identifiable accidental causes (e.g., DROWNING; WOUNDS AND INJURIES).	""	0	#FFFFFF
D000080842	C23.550.291.968	Undiagnosed Diseases	Rare and common diseases lacking a diagnosis.	""	0	#FFFFFF
D000080874	C10.574.928|C18.452.845.650	Synucleinopathies	Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.	""	0	#FFFFFF
D000080883	C12.050.703.420.288.364	Shoulder Dystocia	Obstetric complication during OBSTETRIC DELIVERY in which exit of the fetus is delayed due to physical obstruction involving fetal shoulder(s).	""	0	#FFFFFF
D000080888	C10.597.606.150.500.550.500|C23.888.592.604.150.500.550.500|C23.888.592.604.150.550.600	Specific Language Disorder	Language disorder that delays the mastery of oral language skills or  in children who have no hearing loss or other developmental delays.	""	0	#FFFFFF
D000080902	C07.465.299.625.500.349.750|C10.292.200.875.750|C10.292.319.625.700.349.750|C10.900.300.218.775.750|C26.915.300.400.825.750	Mandibular Nerve Injuries	Traumatic injuries to the MANDIBULAR NERVE and its branches. Note that marginal mandibular nerve injury is a type of FACIAL NERVE INJURIES. Injuries to LINGUAL NERVE branch of mandibular nerve is LINGUAL NERVE INJURIES.	""	0	#FFFFFF
D000080942	C10.228.140.199.850|C14.280.778|C14.907.725.638|C23.550.767.877.625	Post-Cardiac Arrest Syndrome	A reperfusion syndrome characterized by various pathophysiological processes after CARDIAC ARREST.  It may include post-cardiac arrest brain injury (HYPOXIA-ISCHEMIA, BRAIN), cardiocirculatory dysfunction, (e.g., systemic ISCHEMIA), HYPERGLYCEMIA; MULTIPLE ORGAN FAILURE and delayed death.	""	0	#FFFFFF
D000080983	C15.378.190.223	Bone Marrow Failure Disorders	Inherited or acquired diseases characterized by insufficient and/or dysplastic blood cells.	""	0	#FFFFFF
D000080984	C15.378.190.223.500|C16.614.183	Congenital Bone Marrow Failure Syndromes	Inherited syndromes characterized by deficiency or absence of various blood cells due to mutations that affect HEMATOPOIETIC STEM CELLS development and proliferation.	""	0	#FFFFFF
D000081003	C06.689.276.500|C15.378.190.223.500.875|C18.452.584.563.824|C18.452.584.718.875	Shwachman-Diamond Syndrome	An inherited syndrome characterized by EXOCRINE PANCREATIC INSUFFICIENCY; hematologic abnormalities (e.g., bone marrow hypoplasia), and skeletal abnormalities (e.g., metaphyseal chondroplasia). GERMLINE MUTATIONS in the SBDS gene are associated with Shwachman-Diamond Syndrome.	""	0	#FFFFFF
D000081011	C06.552.289|C23.550.513.355.500|C23.550.717.489.500	Hepatic Infarction	Formation of infarct resulting from obstruction of HEPATIC ARTERY and/or PORTAL VEIN most often after LIVER TRANSPLANTATION or hepatobiliary surgery.	""	0	#FFFFFF
D000081012	C06.689.750.830.500|C20.111.296|C23.550.291.500.750.500	Autoimmune Pancreatitis	Chronic pancreatitis associated with autoimmune diseases.	""	0	#FFFFFF
D000081015	C09.218.788|C23.550.753|C25.100.656|C26.733.650	Ototoxicity	Damage to the EAR or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	""	0	#FFFFFF
D000081028	C10.292.200.750.500|C10.292.700.475.500|C10.900.300.218.550.500|C11.640.530.500|C23.550.877|C25.100.937|C26.733.902	Toxic Optic Neuropathy	Damage to the eye or its function (e.g., VISUAL IMPAIRMENT) due to OPTIC NERVE damage secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	""	0	#FFFFFF
D000081029	C08.381.423.847	Pulmonary Arterial Hypertension	A progressive rare pulmonary disease characterized by high blood pressure in the PULMONARY ARTERY.	""	0	#FFFFFF
D000081030	C05.651.682|C10.668.491.628|C23.550.706|C25.100.828|C26.733.411	Myotoxicity	Damage to the muscle or its function secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	""	0	#FFFFFF
D000081032	C06.689.750.325	Pancreatitis, Acute Hemorrhagic	An acute INFLAMMATION of the PANCREAS in which the initial edematous pancreatitis evolved into necrosis accompanied by HEMORRHAGE.	""	0	#FFFFFF
D000081084	C26.040	Accidental Injuries	Injuries resulting from events or circumstances that are unforeseen, unplanned, unanticipated, and without premeditation.	""	0	#FFFFFF
D000081207	C16.320.798|C20.673.795	Primary Immunodeficiency Diseases	Genetic immunologic deficiency diseases and syndromes due to mutations in genes involved in IMMUNITY generally characterized by an increased susceptibility to infectious diseases. They are often associated with AUTOIMMUNE DISEASE manifestations.	""	0	#FFFFFF
D000081208	C16.320.798.500|C20.673.795.500	Hereditary Complement Deficiency Diseases	Genetic disorders due to mutations in genes involved in COMPLEMENT SYSTEM PROTEINS. They are often classified into distinct pathway of complement activation where causative mutations are found (e.g., classical pathway, lectin pathway, alternative pathway, and terminal complement pathway).	""	0	#FFFFFF
D000081483	C23.149.688	Squamous Intraepithelial Lesions	A cytological test finding that shows abnormal lesions of SQUAMOUS EPITHELIAL cells.	""	0	#FFFFFF
D000082122	C23.300.707.960	Internal Hernia	A protrusion of an internal abdominal organ through a hole in an anatomical structure such as a muscle or a membrane. For instance, in paraduodenal hernia the SMALL INTESTINE herniates through an opening in the MESENTERIES. It includes intra-abdominal and diaphragmatic hernias. In abdominal hernia a protrusion occurs through a weak spot in the muscle of the ABDOMINAL WALL.	""	0	#FFFFFF
D000082123	C23.300.707.960.750	Paraduodenal Hernia	A protrusion of the SMALL INTESTINE through an opening in the MESENTERY.	""	0	#FFFFFF
D000082242	C07.465.815.178|C15.378.553.231.774|C15.604.315.459	Kimura Disease	A chronic inflammatory disease characterized by benign enlargement of cervical LYMPH NODE and SALIVARY GLANDS with increased levels of IMMUNOGLOBULIN E. Unlike ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA it involves eosinophil infiltrates in lymph node and salivary glands and mostly found in Asian males.	""	0	#FFFFFF
D000082602	C05.550.518.384.500|C05.660.297|C16.131.621.297	Developmental Dysplasia of the Hip	Dislocation of the HIP JOINT from an abnormal FEMORAL HEAD to the ACETABULUM relationship. It is most often due to ligamentous laxity, abnormal positioning of the joint and various other developmental, congenital factors, and method of delivery (e.g., OLIGOHYDRAMNIOS). When dislocation is diagnosed in neonates it is referred to as CONGENITAL HIP DYSPLASIA.	""	0	#FFFFFF
D000082643	C10.597.210|C23.300.220|C23.888.592.206	Cerebral Cortical Thinning	Decrease in CEREBRAL CORTICAL THICKNESS.	""	0	#FFFFFF
D000082802	C04.697.098.500.580|C23.550.727.098.500.580	Warburg Effect, Oncologic	An observation in neoplastic cellular transformation, characterized by an increased glucose uptake via glycolytic activities resulting in an increased LACTATE production under aerobic microenvironment.	""	0	#FFFFFF
D000082843	C12.050.351.500.056.630.728|C12.100.250.056.630.728|C19.391.630.728|C23.300.970.625	Ovarian Torsion	A condition that occurs when an ovary twists around the ligaments that hold it in place. This twisting can cut off blood flow. It usually affects only one ovary.	""	0	#FFFFFF
D000082862	C14.280.484.048	Aortic Valve Disease	Diseases involving the AORTIC VALVE functionality. Aortic valve disease often results in a backward and/or regurgitated blood flow into the LEFT VENTRICLE or a decreased blood flow from the heart. It includes congenital (e.g., bicuspid aortic valve), syndromic, and acquired (e.g., age-related, infection-associated) conditions.	""	0	#FFFFFF
D000082882	C14.240.400.186|C14.280.400.186|C14.280.484.048.875|C16.131.240.400.186	Bicuspid Aortic Valve Disease	Congenital heart valve defects where the AORTIC VALVE has two instead of normal three cusps. It is often associated with AORTIC REGURGITATION and AORTIC INSUFFICIENCY.	""	0	#FFFFFF
D000082902	C14.240.400.818|C14.280.400.818|C14.280.484.048.937|C16.131.240.400.817	Quadricuspid Aortic Valve	Congenital malformation where the AORTIC VALVE has four instead of three cusps. It is often associated with AORTIC REGURGITATION and AORTIC VALVE STENOSIS.	""	0	#FFFFFF
D000082903	C14.240.400.118|C14.280.400.118|C16.131.240.400.118	Aortico-Ventricular Tunnel	Congenital anomaly characterized by an extra-cardiac channel connecting the AORTA either to the right or left HEART VENTRICLE.	""	0	#FFFFFF
D000083023	C04.588.274.476.411.307.180.400|C06.301.371.411.307.180.400|C06.405.249.411.307.180.400|C06.405.469.158.356.180.400|C06.405.469.491.307.180.400	Colitis-Associated Neoplasms	Colonic neoplasms associated with chronic inflammation conditions such as ULCERATIVE COLITIS and CROHN DISEASE.	""	0	#FFFFFF
D000083082	C14.907.137.671	Popliteal Artery Entrapment Syndrome	Entrapment of the POPLITEAL ARTERY in the LEG due to an abnormal course of the artery often associated with onset of development and/or overuse of the gastrocnemius or popliteus muscles on the back of the leg. It is most often associated with runners and other athletes with enlarged calf muscle that compresses the popliteal artery.	""	0	#FFFFFF
D000083083	C16.320.488	Laminopathies	Congenital neuromuscular and muscular dystrophy diseases associated with mutations in the LAMIN TYPE A (Lamin A/C or LMNA gene). It includes CARDIOMYOPATHY, DILATED, 1A; CHARCOT-MARIE-TOOTH DISEASE, type 2B1; EMERY-DREIFUSS MUSCULAR DYSTROPHY, types 2 and 3; HUTCHINSON-GILFORD PROGERIA SYNDROME; LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2; Malouf syndrome; Mandibuloacral dysplasia; LMNA-related muscular dystrophy; Restrictive dermopathy, lethal; Heart-hand syndrome, Slovenian type.	""	0	#FFFFFF
D000083102	C26.741	Reinjuries	Damage inflicted on the same body part as a previous injury.	""	0	#FFFFFF
D000083143	C05.651.534.500.350.500|C10.668.491.175.500.350.500|C16.320.322.625.500|C16.320.577.350.500	X-Linked Emery-Dreifuss Muscular Dystrophy	Emery-Dreifuss muscular dystrophy associated with mutations on emerin (EMD gene) or four and a half LIM domains 1 (FHL1 gene) both located on X chromosome.	""	0	#FFFFFF
D000083144	C05.651.534.500.350.250|C10.668.491.175.500.350.250|C16.320.488.500|C16.320.577.350.250	Autosomal Emery-Dreifuss Muscular Dystrophy	Emery-Dreifuss muscular dystrophy associated with mutations on LAMINS (LMNA gene).	""	0	#FFFFFF
D000083182	C05.651.180.180|C14.907.303.180|C23.550.291.500.282	Chronic Exertional Compartment Syndrome	Compartment syndrome characterized by pain in muscle groups with elevated compartment pressures due most often exercise training in athletes. Most often encountered chronic exertional compartment syndrome is in the anterior or deep posterior compartments of the lower leg in athletes in training similar to POPLITEAL ARTERY ENTRAPMENT SYNDROME.	""	0	#FFFFFF
D000083242	C10.228.140.300.775.400|C14.907.253.855.400	Ischemic Stroke	Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin.	""	0	#FFFFFF
D000083244	C10.228.140.300.775.400.750|C14.907.253.855.400.750	Thrombotic Stroke	A type of ischemic stroke resulting from obstruction due to a BLOOD CLOT formed within in a CEREBRAL ARTERY often associated with ATHEROSCLEROSIS. A stroke due to a blood clot in a cerebral vein is a venous infarction (see VENOUS INFARCTION, BRAIN).	""	0	#FFFFFF
D000083262	C10.228.140.300.775.400.375|C14.907.253.855.400.375	Embolic Stroke	An ischemic stroke due to a blood clot, emboli or other types of blockage which forms somewhere other than the brain and subsequently travels near and restricts blood flow to the brain. Most often the origin of the clot is from the heart and is referred to as cardioembolic stroke.	""	0	#FFFFFF
D000083302	C10.228.140.300.775.300|C14.907.253.855.300	Hemorrhagic Stroke	Stroke due to rupture of a weakened blood vessel in the brain (e.g., CEREBRAL HEMISPHERES; CEREBELLUM; SUBARACHNOID SPACE).	""	0	#FFFFFF
D000083402	C14.240.850.930|C16.131.240.850.902	Persistent Left Superior Vena Cava	Finding of the SUPERIOR VENA CAVA on the left instead of the usual right side of the ASCENDING AORTA. In bilateral superior vena cava it is found on both sides.	""	0	#FFFFFF
D000083682	C25.775.383.500|C25.775.643.500.700	Opiate Overdose	Accidental or deliberate use of an OPIOID in excess of normal dosage. It includes overdose for prescription and illicit opioids.	""	0	#FFFFFF
D000084002	C01.150.703.302.720.745|C01.800.200.720.745|C17.800.174.640.500|C17.800.815.650.500|C17.800.838.208.883.608	Tinea cruris	Fungal infection of the groin. The main causative fungus is TRICHOPHYTON.	""	0	#FFFFFF
D000084063	C23.550.291.937.250	Reinfection	Infection by the same infectious agent following a recovery. Reinfection may be by a different strain or  the same strain.	""	0	#FFFFFF
D000084122	C04.588.894.309.250|C14.280.459.250	Cardiac Papillary Fibroelastoma	Primary tumors, predominantly of the CARDIAC VALVES, characterized by multiple papillary frond structures. Although histologically benign, they may result in complications (e.g., valve dysfunction, EMBOLISM; STROKE; and SUDDEN DEATH).	""	0	#FFFFFF
D000084202	C25.100.429	Chemotherapy-Related Cognitive Impairment	The diminished or impaired mental and/or intellectual function associated with the chemical treatment of cancer.	""	0	#FFFFFF
D000084322	C09.218.568.900.663	Semicircular Canal Dehiscence	A vestibular disorder caused by a pathologic third window into the BONY LABYRINTH (in contrast to the normal ROUND WINDOW OF EAR and the OVAL WINDOW OF EAR). It can present with autophony, sound- or pressure-induced VERTIGO, and chronic disequilibrium among other vestibulocochlear symptoms.(From: Semin Neurol. 2020 Jan 27; 48: 58-65.)	""	0	#FFFFFF
D000084462	C23.888.119.455|C26.522.750	Hyperthermia	An abnormal elevation of body temperature, usually as a result of inability to regulate core body temperature due to non-pathologic factors.	""	0	#FFFFFF
D000085142	C01.920.930.831|C01.925.782.147.905	Severe Fever with Thrombocytopenia Syndrome	A tick-borne infection with SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME BUNYAVIRUS of the genus Phlebovirus. It is associated with fever, THROMBOCYTOPENIA; LEUKOCYTOPENIA, and multiorgan dysfunction. It is found in parts of Asia including China, Japan, Korea and Vietnam and can be transmitted from infected domestic animals and humans.	""	0	#FFFFFF
D000085343	C01.550	Latent Infection	Delayed infection of the host by a dormant or inactive pathogen.	""	0	#FFFFFF
D000085583	C18.452.565.300	Hyperferritinemia	A finding of elevated serum level of FERRITIN. It is often associated with IRON OVERLOAD, repeated blood transfusions, malignancy, iron metabolic syndromes, virus infection, liver injury or dysfunction, and renal failure. Hyperferritinemia in iron metabolic syndromes (e.g., Still's diseases, and HEMOPHAGOCYTIC SYNDROME) is referred to as dysmetabolic hyperferritinemia.	""	0	#FFFFFF
D000086002	C04.557.470.035.510.757|C04.557.470.660.510.757|C04.588.894.797.520.173|C04.588.894.797.640.350|C08.381.540.144|C08.785.520.124|C08.785.640.350	Mesothelioma, Malignant	A type of mesothelioma with a tendency to metastasize.  Most tumors originate from either the PLEURA or PERITONEUM, tumors may also originate in the PERICARDIUM or testicular tissue. It is associated with ASBESTOS exposure. Somatic mutations identified in WT1, BCL10, CDKN2A, NF2, and BAP1 genes are associated with the malignancy. OMIM: 156240.	""	0	#FFFFFF
D000086382	C01.748.610.763.500|C01.925.705.500|C01.925.782.600.550.200.163|C08.381.677.807.500|C08.730.610.763.500	COVID-19	A viral disorder generally characterized by high FEVER; COUGH; DYSPNEA; CHILLS; PERSISTENT TREMOR; MUSCLE PAIN; HEADACHE; SORE THROAT; a new loss of taste and/or smell (see AGEUSIA and ANOSMIA) and other symptoms of a VIRAL PNEUMONIA. In severe cases, a myriad of coagulopathy associated symptoms often correlating with COVID-19 severity is seen (e.g., BLOOD COAGULATION; THROMBOSIS; ACUTE RESPIRATORY DISTRESS SYNDROME; SEIZURES; HEART ATTACK; STROKE; multiple CEREBRAL INFARCTIONS; KIDNEY FAILURE; catastrophic ANTIPHOSPHOLIPID ANTIBODY SYNDROME and/or DISSEMINATED INTRAVASCULAR COAGULATION). In younger patients, rare inflammatory syndromes are sometimes associated with COVID-19 (e.g., atypical KAWASAKI SYNDROME; TOXIC SHOCK SYNDROME; pediatric multisystem inflammatory disease; and CYTOKINE STORM SYNDROME). A coronavirus, SARS-CoV-2, in the genus BETACORONAVIRUS is the causative agent.	""	0	#FFFFFF
D000086582	C10.597.751.600.500|C23.888.592.763.550.500	Anosmia	Complete or severe loss of the subjective sense of smell. Loss of smell may be caused by many factors such as a cold, allergy, OLFACTORY NERVE DISEASES, viral RESPIRATORY TRACT INFECTIONS (e.g., COVID-19), aging and various neurological disorders (e.g., ALZHEIMER DISEASE).	""	0	#FFFFFF
D000086722	C23.888.852.834	Rhinorrhea	Excess nasal drainage.	""	0	#FFFFFF
D000086965	C01.925.933|C01.973.500|C22.969.500	Viral Zoonoses	Viral infections that may be transmitted between non-human animals and HUMANS.	""	0	#FFFFFF
D000086966	C01.150.252.162|C01.973.250|C22.969.250	Bacterial Zoonoses	Bacterial infections that may be transmitted between non-human animals and HUMANS.	""	0	#FFFFFF
D000086982	C01.221.250|C23.550.291.531.500	Blood-Borne Infections	Diseases due to or propagated by body fluids from hosts whose BLOOD has been contaminated with pathogens.	""	0	#FFFFFF
D000087122	C10.597.606.483|C23.888.592.604.487	Mania	A state of elevated excitement with over-activity sometimes accompanied with psychotic symptoms (e.g., PSYCHOMOTOR AGITATION, inflated SELF ESTEEM and flight of ideas). It is often associated with mental disorders (e.g., CYCLOTHYMIC DISORDER; and BIPOLAR DISEASES).	""	0	#FFFFFF
D000087505	C10.228.140.390	Diaschisis	Loss or decreased brain function within intact region of the brain distant from the site of the lesion.	""	0	#FFFFFF
D000087525	C23.550.355.663|C26.733.685	Radiation Fibrosis Syndrome	Radiation-induced fibrosis due to increased production of FIBRIN. Its symptoms include CERVICAL DYSTONIA, difficulty with speech and swallowing, swelling in the radiation field and TRISMUS.	""	0	#FFFFFF
D000088282	C10.574.945.312	Corticobasal Degeneration	Rare progressive neurological disorder characterized by Parkinsonism, cortical atrophy of multiple areas of the brain including the cerebral cortex and the basal ganglia, cognitive dysfunction and eye movement abnormalities.	""	0	#FFFFFF
D000088323	C10.228.140.300.794|C14.907.253.896	Vascular Depression	Late-life depression associated with clinical or MRI defined cerebrovascular pathology.	""	0	#FFFFFF
D000088442	C14.280.647.500.328|C14.907.585.500.422|C23.550.513.355.750.328|C23.550.717.489.750.328	MINOCA	Myocardial infarction in the absence of obstructive coronary artery disease. CORONARY CIRCULATION disruption is due to various other factors such as ATHEROSCLEROTIC PLAQUE and CORONARY VASOSPASM.	""	0	#FFFFFF
D000088562	C01.645|C23.550.291.902	Persistent Infection	Infection which lasts for a long period with continuous display of clinical features. Persistent infection arises due to inability of host cells to clear primary infections completely. When persistent infections are cleared so that infection symptoms are under control they are often referred to as chronic infections. LATENT INFECTIONS are infections in which manifestation of clinical symptoms appear later.	""	0	#FFFFFF
D000089083	C23.888.104	Body Odor	Strong or unusual odor related to the body. Occasional abnormal body odor may be a temporary effect of a metabolic change.	""	0	#FFFFFF
D000089183	C05.116.900.853.625.800.744|C05.550.069.340|C05.550.114.865.800.744	Axial Spondyloarthritis	A spectrum of chronic inflammatory conditions affecting the axial joints (e.g., SPINE), characterized by pain, stiffness of joints (ANKYLOSIS), reduced mobility and inflammation. When joint inflammation and damage are visible on regular X-rays it is called ANKYLOSING SPONDYLITIS; otherwise it is referred to as NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS. HLA-B27 ANTIGEN is a biomarker and IL-23/IL-17 pathway a potential therapeutic target for axial and other related spondyloarthritis.	""	0	#FFFFFF
D000089202	C05.116.900.853.625.800.744.250|C05.550.069.340.250|C05.550.114.865.800.744.250	Non-Radiographic Axial Spondyloarthritis	Chronic inflammatory conditions affecting the axial joints which cannot be detectable on x-rays. It is characterized by pain, stiffness of joints and inflammation. Non-radiographic axial spondyloarthritis can have symptoms onset before the age of 45 and progress to more severe ANKYLOSING SPONDYLITIS over time.	""	0	#FFFFFF
D000089802	C14.907.137.126.307.500.500|C14.907.617.671.500|C23.550.291.500.298|C23.550.513.178	Chronic Limb-Threatening Ischemia	A severe form of peripheral artery disease in which a hypoperfusion of the BLOOD through an organ or tissue is caused by occlusion of peripheral arterial vessels. It is associated with the presence of chronic ischemic rest pain, ulceration or GANGRENE.	""	0	#FFFFFF
D000089965	C17.800.229.100|C23.888.885.328.500|C26.200.413	Erythema Ab Igne	A cutaneous finding caused by prolonged heat exposure (e.g., space heater) and local heat injury (e.g., caused by LASER THERAPY). It is characterized by epidermal atrophy, reticular hyperpigmentation, and telangiectatic dermatosis.	""	0	#FFFFFF
D000090004	C23.550.291.156	Ambulatory Care Sensitive Conditions	Various health conditions in OUTPATIENT CARE settings for which adequate management, treatment and interventions delivered in the ambulatory care setting could potentially prevent HOSPITALIZATION.	""	0	#FFFFFF
D000090122	C14.907.355.830.573|C17.800.862.406	Livedoid Vasculopathy	A rare cutaneous thrombotic disease due to occlusion of dermal vessels. It is characterized by purpuric maculae and ulcerations especially during summer which form scars called atrophie blanche. It is more associated with other syndromes (e.g., PROTEIN C DEFICIENCY; HYPERHOMOCYSTEINEMIA).	""	0	#FFFFFF
D000090124	C06.405.469.462	Intestinal Failure	Various intestinal diseases functionally defined as having reduced intestine function requiring PARENTERAL NUTRITION.	""	0	#FFFFFF
D000090267	C20.762.500	Mast Cell Activation Syndrome	A clinically and genetically heterogeneous group of mast cell disorders in which there is aberrant release of mast cell mediators with little to no accompanying proliferation of MAST CELLS.	""	0	#FFFFFF
D000090303	C16.131.077.350.568|C16.131.831.350.568|C16.320.850.250.568|C17.800.804.350.568|C17.800.827.250.568	Focal Facial Dermal Dysplasias	A heterogenous group of genetic disorders characterized by scar-like atrophic lesions on the temple region of the head including preauricular area. Location of skin defects is likely related to defects in fusion of embryonic facial prominences during development of the face. Focal facial dermal dysplasia (FFDD) is generally divided into four subtypes according to the location of the lesions and inheritance pattern: FFDD1 (Brauer syndrome); FFDD2 (Brauer-Setleis syndrome); FFDD3 (Setleis syndrome); and FFDD4. Mutations in TWIST2 Protein and/or CYP26C1 (see CYP26 FAMILY) are associated with FFDD3, and 4.	""	0	#FFFFFF
D000090362	C20.762	Mast Cell Activation Disorders	A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and characterized by an aberrant release of mast cell mediators which result in multiple and variable inflammatory and allergic symptoms. These disorders are associated with various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other genes, underlying conditions, and responses to allergic or non-allergic triggers of mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics, muscle relaxants, specific foods, environmental toxins, physical conditions such as vibration, cold, pressure, and stress.	""	0	#FFFFFF
D000090463	C18.452.565.400	Iron Deficiencies	Deficient amounts of iron in the body as a result of blood loss, diets deficient in iron, or an iron uptake or storage disorder.	""	0	#FFFFFF
D000090542	C16.320.565.398.481.500|C18.452.584.500.500.644.475.500|C18.452.584.563.481.500|C18.452.648.398.481.500	Homozygous Familial Hypercholesterolemia	A rare inherited genetic disorder, one form of HYPERLIPOPROTEINEMIA TYPE II, characterized by high level of LOW-DENSITY LIPOPROTEIN (LDL) which if not treated could elevate the chance of heart attack at an early age.	""	0	#FFFFFF
D000090862	C10.586|C23.550.470.544	Neuroinflammatory Diseases	Diseases characterized by inflammation of the nervous tissue.	""	0	#FFFFFF
D000090882	C14.907.355.830.749|C15.378.100.876|C23.550.470.895	Thromboinflammation	Thrombosis with associated inflammation due to crosstalk between HEMOSTASIS and INNATE IMMUNE RESPONSES modulated by PLATELETS. It is associated with many diseases such as COVID-19; SICKLE CELL ANEMIA; and THROMBOPHLEBITIS.	""	0	#FFFFFF
D000091323	C10.597.742.357|C23.888.592.742.357	Psychogenic Nonepileptic Seizures	Seizures caused by psychological factors without electrophysiological epileptic changes.	""	0	#FFFFFF
D000091622	C23.888.144.243.926.750|C23.888.144.243.963.750	Weight Cycling	Repeated cycles of weight loss followed by weight gain.	""	0	#FFFFFF
D000091642	C12	Urogenital Diseases	Pathological processes of the URINARY TRACT and the reproductive system (GENITALIA).	""	0	#FFFFFF
D000091662	C12.100	Genital Diseases	Pathological processes involving the reproductive tract (GENITALIA).	""	0	#FFFFFF
D000126	C06.405.748.045|C18.452.076.087	Achlorhydria	A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.	""	0	#FFFFFF
D000130	C05.116.099.343.110|C05.116.099.708.017|C16.320.240.500	Achondroplasia	An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)	""	0	#FFFFFF
D000137	C18.452.076	Acid-Base Imbalance	Disturbances in the ACID-BASE EQUILIBRIUM of the body.	""	0	#FFFFFF
D000138	C18.452.076.176	Acidosis	A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.	""	0	#FFFFFF
D000140	C18.452.076.176.180	Acidosis, Lactic	Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.	""	0	#FFFFFF
D000141	C12.050.351.968.419.815.093|C12.200.777.419.815.093|C12.950.419.815.093|C16.320.831.093|C18.452.076.176.210	Acidosis, Renal Tubular	A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.	""	0	#FFFFFF
D000142	C08.618.846.093|C18.452.076.176.310	Acidosis, Respiratory	Respiratory retention of carbon dioxide. It may be chronic or acute.	""	0	#FFFFFF
D000151	C01.150.252.400.560.022	Acinetobacter Infections	Infections with bacteria of the genus ACINETOBACTER.	""	0	#FFFFFF
D000152	C17.800.030.150|C17.800.794.111	Acne Vulgaris	A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.	""	0	#FFFFFF
D000153	C17.300.200.425.125|C17.800.030.030|C17.800.329.500.261	Acne Keloid	A type of acneiform disorder in which secondary pyogenic infection in and around pilosebaceous structures ends in keloidal scarring. It manifests as persistent folliculitis of the back of the neck associated with occlusion of the follicular orifices. It is most often encountered in black or Asian men.	""	0	#FFFFFF
D000160	C09.218.807.800|C10.292.910	Vestibulocochlear Nerve Diseases	Pathological processes of the VESTIBULOCOCHLEAR NERVE, including the branches of COCHLEAR NERVE and VESTIBULAR NERVE. Common examples are VESTIBULAR NEURITIS, cochlear neuritis, and ACOUSTIC NEUROMA. Clinical signs are varying degree of HEARING LOSS; VERTIGO; and TINNITUS.	""	0	#FFFFFF
D000163	C01.221.250.875.040|C01.221.812.640.400.040|C01.778.640.400.040|C01.925.782.815.616.400.040|C01.925.813.400.040|C01.925.839.040|C12.100.937.640.400.040|C20.673.480.040	Acquired Immunodeficiency Syndrome	An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.	""	0	#FFFFFF
D000168	C05.116.099.370.894.232.015|C05.116.099.370.894.819.100|C05.660.207.240.100|C05.660.585.800.100|C05.660.906.364.100|C05.660.906.819.100|C16.131.621.207.240.100|C16.131.621.585.800.100|C16.131.621.906.364.100|C16.131.621.906.819.100	Acrocephalosyndactylia	Congenital craniostenosis with syndactyly.	""	0	#FFFFFF
D000169	C16.131.831.066|C17.800.174.100|C17.800.804.066	Acrodermatitis	Inflammation involving the skin of the extremities, especially the hands and feet. Several forms are known, some idiopathic and some hereditary. The infantile form is called Gianotti-Crosti syndrome.	""	0	#FFFFFF
D000170	C10.668.829.025|C10.720.475.600.150|C25.723.522.875.500.100	Acrodynia	A condition seen primarily in childhood, most often resulting from chronic exposure to MERCURY COMPOUNDS which may result in encephalopathy and POLYNEUROPATHY. Clinical features include pain, swelling and pinkish discoloration of the fingers and toes, weakness in the extremities, extreme irritability, HYPERESTHESIA, and alterations in level of consciousness. (From Menkes, Textbook of Child Neurology, 5th ed, p603)	""	0	#FFFFFF
D000172	C05.116.132.082|C10.228.140.617.738.250.100|C19.700.355.179	Acromegaly	A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)	""	0	#FFFFFF
D000182	C04.730.713.317	ACTH Syndrome, Ectopic	Symptom complex due to ACTH production by non-pituitary neoplasms.	""	0	#FFFFFF
D000187	C01.150.252.400.700.030.178|C22.039	Actinobacillosis	A disease characterized by suppurative and granulomatous lesions in the respiratory tract, upper alimentary tract, skin, kidneys, joints, and other tissues. Actinobacillus lignieresii infects cattle and sheep while A. equuli infects horses and pigs.	""	0	#FFFFFF
D000189	C01.150.252.400.700.030	Actinobacillus Infections	Infections with bacteria of the genus ACTINOBACILLUS.	""	0	#FFFFFF
D000193	C01.150.252.410.040	Actinomycetales Infections	Infections with bacteria of the order ACTINOMYCETALES.	""	0	#FFFFFF
D000196	C01.150.252.410.040.137	Actinomycosis	Infections with bacteria of the genus ACTINOMYCES.	""	0	#FFFFFF
D000197	C01.150.252.410.040.137.316|C01.150.252.819.110|C01.800.720.110|C17.800.838.765.110	Actinomycosis, Cervicofacial	A form of ACTINOMYCOSIS characterized by slow-growing inflammatory lesions of the lymph nodes that drain the mouth (lumpy jaw), reddening of the overlying skin, and intraperitoneal abscesses.	""	0	#FFFFFF
D000208	C23.550.291.125	Acute Disease	Disease having a short and relatively severe course.	""	0	#FFFFFF
D000210	C23.550.470.099	Acute-Phase Reaction	An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.	""	0	#FFFFFF
D000219	C14.280.067.558.137|C14.280.123.500.137|C23.550.073.425.025	Adams-Stokes Syndrome	A condition of fainting spells caused by heart block, often an atrioventricular block, that leads to BRADYCARDIA and drop in CARDIAC OUTPUT. When the cardiac output becomes too low, the patient faints (SYNCOPE). In some cases, the syncope attacks are transient and in others cases repetitive and persistent.	""	0	#FFFFFF
D000224	C19.053.500.263|C20.111.163	Addison Disease	An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.	""	0	#FFFFFF
D000230	C04.557.470.200.025	Adenocarcinoma	A malignant epithelial tumor with a glandular organization.	""	0	#FFFFFF
D000231	C04.557.470.200.025.085	Adenocarcinoma, Papillary	An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)	""	0	#FFFFFF
D000232	C04.557.450.565.590.595.050|C04.557.470.625.050	Adenofibroma	A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)	""	0	#FFFFFF
D000235	C04.557.435.075	Adenolymphoma	A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.	""	0	#FFFFFF
D000236	C04.557.470.035	Adenoma	A benign epithelial tumor with a glandular organization.	""	0	#FFFFFF
D000237	C04.557.465.625.650.075|C04.557.470.035.075|C04.557.580.625.650.075	Adenoma, Basophil	A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)	""	0	#FFFFFF
D000238	C04.557.465.625.650.095|C04.557.470.035.095|C04.557.580.625.650.095	Adenoma, Chromophobe	A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.	""	0	#FFFFFF
D000239	C04.557.465.625.650.025|C04.557.470.035.025|C04.557.580.625.650.025	Adenoma, Acidophil	A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)	""	0	#FFFFFF
D000257	C01.925.256.076	Adenoviridae Infections	Virus diseases caused by the ADENOVIRIDAE.	""	0	#FFFFFF
D000258	C01.925.256.076.045	Adenovirus Infections, Human	Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.	""	0	#FFFFFF
D000267	C23.550.355.274.840	Tissue Adhesions	Pathological processes consisting of the union of the opposing surfaces of a wound.	""	0	#FFFFFF
D000270	C10.177.045|C10.292.562.700.250|C11.590.436.200|C11.710.800.180	Adie Syndrome	A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279)	""	0	#FFFFFF
D000274	C17.800.463.249|C18.452.584.718.500	Adiposis Dolorosa	A rare disease characterized by multiple tumor-like fatty deposits that press on nerves in various sites causing pain and weakness. Often these lipoma-like structures are located on the trunk and limbs but not on the face and hands.	""	0	#FFFFFF
D000291	C12.050.351.500.056|C12.100.250.056	Adnexal Diseases	Diseases of the uterine appendages (ADNEXA UTERI) including diseases involving the OVARY, the FALLOPIAN TUBES, and ligaments of the uterus (BROAD LIGAMENT; ROUND LIGAMENT).	""	0	#FFFFFF
D000292	C01.635.500|C12.050.351.500.056.750|C12.100.250.056.750	Pelvic Inflammatory Disease	A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.	""	0	#FFFFFF
D000303	C19.053.098	Adrenal Cortex Diseases	Pathological processes of the ADRENAL CORTEX.	""	0	#FFFFFF
D000306	C04.588.322.078.265|C19.053.098.265|C19.053.347.500|C19.344.078.265	Adrenal Cortex Neoplasms	Tumors or cancers of the ADRENAL CORTEX.	""	0	#FFFFFF
D000307	C19.053	Adrenal Gland Diseases	Pathological processes of the ADRENAL GLANDS.	""	0	#FFFFFF
D000308	C19.053.800	Adrenocortical Hyperfunction	Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.	""	0	#FFFFFF
D000309	C19.053.500	Adrenal Insufficiency	Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.	""	0	#FFFFFF
D000310	C04.588.322.078|C19.053.347|C19.344.078	Adrenal Gland Neoplasms	Tumors or cancer of the ADRENAL GLANDS.	""	0	#FFFFFF
D000312	C12.050.351.875.253.090.500|C12.200.706.316.090.500|C12.800.316.090.500|C16.131.939.316.129.500|C16.320.033|C16.320.565.925.249|C18.452.648.925.249|C19.053.440|C19.391.119.090.500	Adrenal Hyperplasia, Congenital	A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.	""	0	#FFFFFF
D000314	C04.557.470.035.232	Adrenal Rest Tumor	Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.	""	0	#FFFFFF
D000326	C10.228.140.163.100.084|C10.228.140.163.100.362.250|C10.228.140.695.625.250|C10.314.400.250|C10.597.606.360.455.124|C16.320.322.500.124|C16.320.400.525.124|C16.320.565.189.084|C16.320.565.189.362.250|C16.320.565.663.100|C18.452.132.100.084|C18.452.132.100.362.250|C18.452.648.189.084|C18.452.648.189.362.250|C18.452.648.663.100|C19.053.500.270	Adrenoleukodystrophy	An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).	""	0	#FFFFFF
D000334	C23.888.821.061	Aerophagy	Spasmodic swallowing of air.	""	0	#FFFFFF
D000343	C06.405.469.531.099|C23.550.767.050	Afferent Loop Syndrome	A complication of gastrojejunostomy (BILLROTH II PROCEDURE), a reconstructive GASTROENTEROSTOMY. It is caused by acute (complete) or chronic (intermittent) obstruction of the afferent jejunal loop due to HERNIA, intussusception, kinking, VOLVULUS, etc. It is characterized by PAIN and VOMITING of BILE-stained fluid.	""	0	#FFFFFF
D000347	C15.378.100.100.056|C15.378.100.141.072|C15.378.463.067|C16.320.099.056	Afibrinogenemia	A deficiency or absence of FIBRINOGEN in the blood.	""	0	#FFFFFF
D000355	C01.920.500.030|C01.925.081.030|C01.925.782.791.142|C22.488.088	African Horse Sickness	An insect-borne reovirus infection of horses, mules and donkeys in Africa and the Middle East; characterized by pulmonary edema, cardiac involvement, and edema of the head and neck.	""	0	#FFFFFF
D000357	C01.920.930.125|C01.925.081.078|C01.925.256.142|C22.905.072	African Swine Fever	A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros).	""	0	#FFFFFF
D000361	C15.378.147.142|C15.604.515.032|C20.673.088	Agammaglobulinemia	An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.	""	0	#FFFFFF
D000370	C10.597.751.861.184|C23.888.592.763.861.184	Ageusia	Complete or severe loss of the subjective sense of taste, frequently accompanied by OLFACTION DISORDERS.	""	0	#FFFFFF
D000377	C10.597.606.762.100|C23.888.592.604.764.100	Agnosia	Loss of the ability to comprehend the meaning or recognize the importance of various forms of stimulation that cannot be attributed to impairment of a primary sensory modality. Tactile agnosia is characterized by an inability to perceive the shape and nature of an object by touch alone, despite unimpaired sensation to light touch, position, and other primary sensory modalities.	""	0	#FFFFFF
D000380	C15.378.553.546.184	Agranulocytosis	A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).	""	0	#FFFFFF
D000381	C10.597.606.150.500.050|C23.888.592.604.150.500.050	Agraphia	Loss or impairment of the ability to write (letters, syllables, words, or phrases) due to an injury to a specific cerebral area or occasionally due to emotional factors. This condition rarely occurs in isolation, and often accompanies APHASIA. (From Adams et al., Principles of Neurology, 6th ed, p485; APA, Thesaurus of Psychological Index Terms, 1994)	""	0	#FFFFFF
D000382	C24.080	Agricultural Workers' Diseases	Diseases in persons engaged in cultivating and tilling soil, growing plants, harvesting crops, raising livestock, or otherwise engaged in husbandry and farming. The diseases are not restricted to farmers in the sense of those who perform conventional farm chores: the heading applies also to those engaged in the individual activities named above, as in those only gathering harvest or in those only dusting crops.	""	0	#FFFFFF
D000386	C01.221.250.875.080|C01.221.812.640.400.080|C01.778.640.400.080|C01.925.782.815.616.400.080|C01.925.813.400.080|C01.925.839.080|C12.100.937.640.400.080|C20.673.480.080	AIDS-Related Complex	A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.	""	0	#FFFFFF
D000387	C05.116.264.143	Ainhum	Spontaneous autoamputation of the fourth or fifth toe.	""	0	#FFFFFF
D000402	C08.618.846.185	Airway Obstruction	Any hindrance to the passage of air into and out of the lungs.	""	0	#FFFFFF
D000405	C10.228.140.042	Akinetic Mutism	A syndrome characterized by a silent and inert state without voluntary motor activity despite preserved sensorimotor pathways and vigilance. Bilateral FRONTAL LOBE dysfunction involving the anterior cingulate gyrus and related brain injuries are associated with this condition. This may result in impaired abilities to communicate and initiate motor activities. (From Adams et al., Principles of Neurology, 6th ed, p348; Fortschr Neurol Psychiatr 1995 Feb;63(2):59-67)	""	0	#FFFFFF
D000417	C11.270.040|C16.320.290.040|C16.320.565.100.102|C16.320.850.080|C17.800.621.440.102|C17.800.827.080|C18.452.648.100.102	Albinism	General term for a number of inherited defects of amino acid metabolism in which there is a deficiency or absence of pigment in the eyes, skin, or hair.	""	0	#FFFFFF
D000419	C12.050.351.968.934.734.269|C12.200.777.934.734.269|C12.950.934.734.269|C23.888.942.750.269	Albuminuria	The presence of albumin in the urine, an indicator of KIDNEY DISEASES.	""	0	#FFFFFF
D000425	C10.720.112.100|C25.723.705.150.100|C25.775.100.087.193.100	Alcohol Amnestic Disorder	A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)	""	0	#FFFFFF
D000430	C10.720.112.200|C25.723.705.150.200|C25.775.100.087.193.200|C25.775.835.250	Alcohol Withdrawal Delirium	An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)	""	0	#FFFFFF
D000435	C25.775.100.175	Alcoholic Intoxication	An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.	""	0	#FFFFFF
D000437	C25.775.100.250	Alcoholism	A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)	""	0	#FFFFFF
D000453	C01.925.256.700.091|C01.925.839.091|C11.270.040.772.270|C20.673.774.257.270|C22.062	Aleutian Mink Disease	A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible.	""	0	#FFFFFF
D000471	C18.452.076.354	Alkalosis	A pathological condition that removes acid or adds base to the body fluids.	""	0	#FFFFFF
D000472	C08.618.501.271|C18.452.076.354.271	Alkalosis, Respiratory	A state due to excess loss of carbon dioxide from the body. (Dorland, 27th ed)	""	0	#FFFFFF
D000474	C16.320.565.100.187|C18.452.648.100.187	Alkaptonuria	An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.	""	0	#FFFFFF
D000505	C17.800.329.937.122|C23.300.035	Alopecia	Absence of hair from areas where it is normally present.	""	0	#FFFFFF
D000506	C17.800.329.937.122.147	Alopecia Areata	Loss of scalp and body hair involving microscopically inflammatory patchy areas.	""	0	#FFFFFF
D000507	C17.300.550.550|C17.800.329.937.122.550|C17.800.794.550	Mucinosis, Follicular	A disease of the pilosebaceous unit, presenting clinically as grouped follicular papules or plaques with associated hair loss. It is caused by mucinous infiltration of tissues, and usually involving the scalp, face, and neck. It may be primary (idiopathic) or secondary to mycosis fungoides or reticulosis.	""	0	#FFFFFF
D000532	C08.618.020	Altitude Sickness	Multiple symptoms associated with reduced oxygen at high ALTITUDE.	""	0	#FFFFFF
D000542	C08.381.483.125|C08.674.055|C20.543.480.680.075	Alveolitis, Extrinsic Allergic	A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.	""	0	#FFFFFF
D000544	C10.228.140.380.100|C10.574.945.249	Alzheimer Disease	A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	""	0	#FFFFFF
D000550	C10.228.140.055|C10.597.751.941.073|C11.966.073|C23.888.592.763.941.073	Amblyopia	A nonspecific term referring to impaired vision. Major subcategories include stimulus deprivation-induced amblyopia and toxic amblyopia. Stimulus deprivation-induced amblyopia is a developmental disorder of the visual cortex. A discrepancy between visual information received by the visual cortex from each eye results in abnormal cortical development. STRABISMUS and REFRACTIVE ERRORS may cause this condition. Toxic amblyopia is a disorder of the OPTIC NERVE which is associated with ALCOHOLISM, tobacco SMOKING, and other toxins and as an adverse effect of the use of some medications.	""	0	#FFFFFF
D000562	C01.610.752.049	Amebiasis	Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur.	""	0	#FFFFFF
D000564	C04.557.695.065	Ameloblastoma	An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.	""	0	#FFFFFF
D000567	C07.650.800.255.500|C07.793.700.255.500|C16.131.850.800.255.500	Amelogenesis Imperfecta	A clinically and genetically heterogeneous group of hereditary conditions characterized by malformed DENTAL ENAMEL, usually involving DENTAL ENAMEL HYPOPLASIA and/or TOOTH HYPOMINERALIZATION.	""	0	#FFFFFF
D000568	C23.550.568.500	Amenorrhea	Absence of menstruation.	""	0	#FFFFFF
D000592	C16.320.565.100|C18.452.648.100	Amino Acid Metabolism, Inborn Errors	Disorders affecting amino acid metabolism. The majority of these disorders are inherited and present in the neonatal period with metabolic disturbances (e.g., ACIDOSIS) and neurologic manifestations. They are present at birth, although they may not become symptomatic until later in life.	""	0	#FFFFFF
D000608	C12.050.351.968.419.815.885|C12.200.777.419.815.885|C12.950.419.815.885|C16.320.831.885	Renal Aminoacidurias	A group of inherited kidney disorders characterized by the abnormally elevated levels of AMINO ACIDS in URINE. Genetic mutations of transport proteins result in the defective reabsorption of free amino acids at the PROXIMAL RENAL TUBULES. Renal aminoaciduria are classified by the specific amino acid or acids involved.	""	0	#FFFFFF
D000647	C10.597.606.525.100|C23.888.592.604.529.100	Amnesia	Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)	""	0	#FFFFFF
D000648	C10.597.606.525.100.150|C23.888.592.604.529.100.150	Amnesia, Retrograde	Loss of the ability to recall information that had been previously encoded in memory prior to a specified or approximate point in time. This process may be organic or psychogenic in origin. Organic forms may be associated with CRANIOCEREBRAL TRAUMA; CEREBROVASCULAR ACCIDENTS; SEIZURES; DEMENTIA; and a wide variety of other conditions that impair cerebral function. (From Adams et al., Principles of Neurology, 6th ed, pp426-9)	""	0	#FFFFFF
D000652	C16.614.042	Amniotic Band Syndrome	A disorder present in the newborn infant in which constriction rings or bands, causing soft tissue depressions, encircle digits, extremities, or limbs and sometimes the neck, thorax, or abdomen. They may be associated with intrauterine amputations.	""	0	#FFFFFF
D000673	C26.062	Amputation, Traumatic	Loss of a limb or other bodily appendage by accidental injury.	""	0	#FFFFFF
D000686	C18.452.845.500	Amyloidosis	A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.	""	0	#FFFFFF
D000690	C10.228.854.139|C10.574.562.250|C10.574.950.050|C10.668.467.250|C18.452.845.800.050	Amyotrophic Lateral Sclerosis	A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)	""	0	#FFFFFF
D000694	C04.588.083|C04.588.274.476.411.307.790.040.040|C06.301.371.411.307.790.040.040|C06.405.249.411.307.790.040.040|C06.405.469.491.307.790.040.040|C06.405.469.860.101.163.083|C06.405.469.860.180.500.040.040|C22.073	Anal Gland Neoplasms	Tumors or cancer of the anal gland.	""	0	#FFFFFF
D000699	C10.668.829.700|C16.320.775	Pain Insensitivity, Congenital	A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)	""	0	#FFFFFF
D000707	C20.543.480.099	Anaphylaxis	An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	""	0	#FFFFFF
D000708	C04.697.045|C23.550.727.045	Anaplasia	Loss of structural differentiation and useful function of neoplastic cells.	""	0	#FFFFFF
D000711	C01.150.252.400.054	Anaplasmataceae Infections	Infections with bacteria of the family ANAPLASMATACEAE.	""	0	#FFFFFF
D000712	C01.150.252.400.054.500|C01.150.252.400.082|C01.920.930.163|C22.085	Anaplasmosis	A disease usually in cattle caused by parasitization of the red blood cells by bacteria of the genus ANAPLASMA.	""	0	#FFFFFF
D000724	C01.610.335.508.700.775.455.154	Ancylostomiasis	Infection of humans or animals with hookworms of the genus ANCYLOSTOMA. Characteristics include anemia, dyspepsia, eosinophilia, and abdominal swelling.	""	0	#FFFFFF
D000740	C15.378.071	Anemia	A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	""	0	#FFFFFF
D000741	C15.378.071.085|C15.378.190.223.250	Anemia, Aplastic	A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.	""	0	#FFFFFF
D000742	C15.378.071.141.150.095|C16.320.070.095	Anemia, Dyserythropoietic, Congenital	A familial disorder characterized by ANEMIA with multinuclear ERYTHROBLASTS, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (ERYTHROID PRECURSOR CELLS). Type II is the most common of the 3 types; it is often referred to as HEMPAS, based on the Hereditary Erythroblast Multinuclearity with Positive Acidified Serum test.	""	0	#FFFFFF
D000743	C15.378.071.141	Anemia, Hemolytic	A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).	""	0	#FFFFFF
D000744	C15.378.071.141.125|C20.111.175	Anemia, Hemolytic, Autoimmune	Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.	""	0	#FFFFFF
D000745	C15.378.071.141.150|C16.320.070	Anemia, Hemolytic, Congenital	Hemolytic anemia due to various intrinsic defects of the erythrocyte.	""	0	#FFFFFF
D000746	C15.378.071.141.150.100|C16.320.070.100	Anemia, Hemolytic, Congenital Nonspherocytic	Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. Common causes include deficiencies in GLUCOSE-6-PHOSPHATE ISOMERASE; PYRUVATE KINASE; and GLUCOSE-6-PHOSPHATE DEHYDROGENASE.	""	0	#FFFFFF
D000747	C15.378.071.196	Anemia, Hypochromic	Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)	""	0	#FFFFFF
D000748	C15.378.071.252	Anemia, Macrocytic	Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).	""	0	#FFFFFF
D000749	C15.378.071.252.196	Anemia, Megaloblastic	A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.	""	0	#FFFFFF
D000750	C15.378.071.307|C15.378.190.636.085	Anemia, Myelophthisic	Anemia characterized by appearance of immature myeloid and nucleated erythrocytes in the peripheral blood, resulting from infiltration of the bone marrow by foreign or abnormal tissue.	""	0	#FFFFFF
D000751	C15.378.071.363|C16.614.053	Anemia, Neonatal	The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation.	""	0	#FFFFFF
D000752	C15.378.071.252.196.500|C18.654.521.500.133.699.923.280	Anemia, Pernicious	A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)	""	0	#FFFFFF
D000753	C15.378.071.400|C15.378.190.625.062	Anemia, Refractory	A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy.	""	0	#FFFFFF
D000754	C15.378.071.400.080|C15.378.190.625.062.080	Anemia, Refractory, with Excess of Blasts	Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.	""	0	#FFFFFF
D000755	C15.378.071.141.150.150|C15.378.420.155|C16.320.070.150|C16.320.365.155	Anemia, Sickle Cell	A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.	""	0	#FFFFFF
D000756	C15.378.071.419|C15.378.190.625.070	Anemia, Sideroblastic	Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.	""	0	#FFFFFF
D000757	C10.500.680.196|C16.131.085.197|C16.131.666.680.196	Anencephaly	A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247)	""	0	#FFFFFF
D000782	C23.550.210.050	Aneuploidy	The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).	""	0	#FFFFFF
D000783	C14.907.055	Aneurysm	Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.	""	0	#FFFFFF
D000784	C14.907.055.050	Aneurysm, Dissecting	An aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the tunica intima and TUNICA MEDIA causes luminal occlusion. Dissection at the media, or between the media and the outer ADVENTITIA causes aneurismal dilation.	""	0	#FFFFFF
D000785	C01.069|C14.907.055.131	Aneurysm, Infected	Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.	""	0	#FFFFFF
D000787	C14.280.647.187|C14.907.585.187|C23.888.592.612.233.500	Angina Pectoris	The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.	""	0	#FFFFFF
D000788	C14.280.647.187.150.150|C14.907.585.187.150.500|C23.888.592.612.233.500.150.150	Angina Pectoris, Variant	A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.	""	0	#FFFFFF
D000789	C14.280.647.187.150|C14.907.585.187.150|C23.888.592.612.233.500.150	Angina, Unstable	Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.	""	0	#FFFFFF
D000793	C11.768.094	Angioid Streaks	Small breaks in the elastin-filled tissue of the retina.	""	0	#FFFFFF
D000794	C04.557.645.115	Angiokeratoma	A vascular, horny neoplasm of the skin characterized by TELANGIECTASIS and secondary epithelial changes including acanthosis and hyperkeratosis.	""	0	#FFFFFF
D000795	C10.228.140.163.100.435.825.200|C10.228.140.300.275.374|C14.907.253.329.374|C16.320.322.124|C16.320.565.189.435.825.200|C16.320.565.398.641.803.300|C16.320.565.595.554.825.200|C18.452.132.100.435.825.200|C18.452.584.563.641.803.300|C18.452.648.189.435.825.200|C18.452.648.398.641.803.300|C18.452.648.595.554.825.200	Fabry Disease	An X-linked inherited metabolic disease caused by a deficiency of lysosomal ALPHA-GALACTOSIDASE A. It is characterized by intralysosomal accumulation of globotriaosylceramide and other GLYCOSPHINGOLIPIDS in blood vessels throughout the body leading to multi-system complications including renal, cardiac, cerebrovascular, and skin disorders.	""	0	#FFFFFF
D000796	C15.378.553.231.085|C15.604.515.292.007|C17.800.060	Angiolymphoid Hyperplasia with Eosinophilia	Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells.	""	0	#FFFFFF
D000798	C14.907.077	Angiomatosis	A condition with multiple tumor-like lesions caused either by congenital or developmental malformations of BLOOD VESSELS, or reactive vascular proliferations, such as in bacillary angiomatosis. Angiomatosis is considered non-neoplastic.	""	0	#FFFFFF
D000799	C14.907.079|C17.800.862.945.066|C20.543.480.904.066	Angioedema	Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.	""	0	#FFFFFF
D000820	C22	Animal Diseases	Diseases that occur in VERTEBRATE animals.	""	0	#FFFFFF
D000839	C11.744.116	Aniseikonia	A condition in which the ocular image of an object as seen by one eye differs in size and shape from that seen by the other.	""	0	#FFFFFF
D000844	C05.550.069	Ankylosis	Fixation and immobility of a joint.	""	0	#FFFFFF
D000848	C07.650.800.100|C07.793.700.100|C16.131.850.800.100	Anodontia	Congenital absence of the teeth; it may involve all (total anodontia) or only some of the teeth (partial anodontia, hypodontia), and both the deciduous and the permanent dentition, or only teeth of the permanent dentition. (Dorland, 27th ed)	""	0	#FFFFFF
D000849	C10.597.606.150.500.090|C23.888.592.604.150.500.090	Anomia	A language dysfunction characterized by the inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name. This condition is associated with lesions of the dominant hemisphere involving the language areas, in particular the TEMPORAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, p484)	""	0	#FFFFFF
D000853	C11.250.080|C16.131.384.159	Anophthalmos	Congenital absence of the eye or eyes.	""	0	#FFFFFF
D000855	C23.888.821.108	Anorexia	The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.	""	0	#FFFFFF
D000857	C10.597.751.600|C23.888.592.763.550	Olfaction Disorders	Impaired ability to smell. This may be caused by OLFACTORY NERVE DISEASES; PARANASAL SINUS DISEASES; viral RESPIRATORY TRACT INFECTIONS; CRANIOCEREBRAL TRAUMA; SMOKING; and other conditions.	""	0	#FFFFFF
D000858	C12.050.351.500.056.630.050|C12.100.250.056.630.050|C19.391.630.050	Anovulation	Suspension or cessation of OVULATION in animals or humans with follicle-containing ovaries (OVARIAN FOLLICLE). Depending on the etiology, OVULATION may be induced with appropriate therapy.	""	0	#FFFFFF
D000860	C23.888.852.079	Hypoxia	Sub-optimal OXYGEN levels in the ambient air of living organisms.	""	0	#FFFFFF
D000868	C05.651.180.063|C14.907.303.063	Anterior Compartment Syndrome	Rapid swelling, increased tension, pain, and ischemic necrosis of the muscles of the anterior tibial compartment of the leg, often following excessive PHYSICAL EXERTION.	""	0	#FFFFFF
D000874	C08.381.483.581.062.500|C08.381.483.581.760.125|C08.381.520.702.062.500|C08.381.520.702.760.125|C24.800.834.201	Anthracosilicosis	A form of pneumoconiosis caused by inhalation of dust that contains both CARBON and crystalline SILICON DIOXIDE. These foreign matters induce fibrous nodule formation in the lung.	""	0	#FFFFFF
D000881	C01.150.252.410.090.072	Anthrax	An acute infection caused by the spore-forming bacteria BACILLUS ANTHRACIS. It commonly affects hoofed animals such as sheep and goats. Infection in humans often involves the skin (cutaneous anthrax), the lungs (inhalation anthrax), or the gastrointestinal tract. Anthrax is not contagious and can be treated with antibiotics.	""	0	#FFFFFF
D001002	C12.050.351.968.419.078|C12.050.351.968.934.070|C12.200.777.419.078|C12.200.777.934.141|C12.950.419.078|C12.950.934.070	Anuria	Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present.	""	0	#FFFFFF
D001004	C06.405.469.860.101	Anus Diseases	Diseases involving the ANUS.	""	0	#FFFFFF
D001005	C04.588.274.476.411.307.790.040|C06.301.371.411.307.790.040|C06.405.249.411.307.790.040|C06.405.469.491.307.790.040|C06.405.469.860.101.163|C06.405.469.860.180.500.040	Anus Neoplasms	Tumors or cancer of the ANAL CANAL.	""	0	#FFFFFF
D001006	C06.198.050|C16.131.314.094	Anus, Imperforate	A congenital abnormality characterized by the persistence of the anal membrane, resulting in a thin membrane covering the normal ANAL CANAL. Imperforation is not always complete and is treated by surgery in infancy. This defect is often associated with NEURAL TUBE DEFECTS; MENTAL RETARDATION; and DOWN SYNDROME.	""	0	#FFFFFF
D001014	C14.907.055.239|C14.907.109.139	Aortic Aneurysm	An abnormal balloon- or sac-like dilatation in the wall of AORTA.	""	0	#FFFFFF
D001015	C14.907.109.239	Aortic Arch Syndromes	Conditions resulting from abnormalities in the arteries branching from the ASCENDING AORTA, the curved portion of the aorta. These syndromes are results of occlusion or abnormal blood flow to the head-neck or arm region leading to neurological defects and weakness in an arm. These syndromes are associated with vascular malformations; ATHEROSCLEROSIS; TRAUMA; and blood clots.	""	0	#FFFFFF
D001017	C14.240.400.090|C14.280.400.090|C16.131.240.400.090	Aortic Coarctation	A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.	""	0	#FFFFFF
D001018	C14.907.109	Aortic Diseases	Pathological processes involving any part of the AORTA.	""	0	#FFFFFF
D001019	C14.907.055.185.125|C14.907.055.239.175|C14.907.109.139.175|C26.761.125	Aortic Rupture	The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.	""	0	#FFFFFF
D001020	C14.280.484.048.750.070|C14.280.955.249.070	Aortic Stenosis, Subvalvular	A pathological constriction occurring in the region below the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.	""	0	#FFFFFF
D001022	C14.280.484.048.500	Aortic Valve Insufficiency	Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).	""	0	#FFFFFF
D001023	C14.280.484.048.625|C14.280.484.400.100	Aortic Valve Prolapse	The downward displacement of the cuspal or pointed end of the trileaflet AORTIC VALVE causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to aortic regurgitation.	""	0	#FFFFFF
D001024	C14.280.484.048.750|C14.280.955.249	Aortic Valve Stenosis	A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.	""	0	#FFFFFF
D001025	C14.907.109.320|C14.907.940.080	Aortitis	Inflammation of the wall of the AORTA.	""	0	#FFFFFF
D001028	C14.240.400.560.098|C14.280.400.560.098|C16.131.240.400.560.098	Aortopulmonary Septal Defect	A developmental abnormality in which the spiral (aortopulmonary) septum failed to completely divide the TRUNCUS ARTERIOSUS into ASCENDING AORTA and PULMONARY ARTERY. This abnormal communication between the two major vessels usually lies above their respective valves (AORTIC VALVE; PULMONARY VALVE).	""	0	#FFFFFF
D001035	C11.510.103	Aphakia	Absence of crystalline lens totally or partially from field of vision, from any cause except after cataract extraction. Aphakia is mainly congenital or as result of LENS DISLOCATION AND SUBLUXATION.	""	0	#FFFFFF
D001036	C11.510.103.110	Aphakia, Postcataract	Absence of the crystalline lens resulting from cataract extraction.	""	0	#FFFFFF
D001037	C10.597.606.150.500.800.100|C23.888.592.604.150.500.800.100	Aphasia	A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.	""	0	#FFFFFF
D001039	C10.597.606.150.500.800.100.100|C23.888.592.604.150.500.800.100.100	Aphasia, Broca	An aphasia characterized by impairment of expressive LANGUAGE (speech, writing, signs) and relative preservation of receptive language abilities (i.e., comprehension). This condition is caused by lesions of the motor association cortex in the FRONTAL LOBE (BROCA AREA and adjacent cortical and white matter regions).	""	0	#FFFFFF
D001041	C10.597.606.150.500.800.100.166|C23.888.592.604.150.500.800.100.166	Aphasia, Wernicke	Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke's area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846)	""	0	#FFFFFF
D001044	C08.360.940.160|C09.400.940.160|C10.597.975.100|C23.888.592.979.100	Aphonia	Complete loss of phonation due to organic disease of the larynx or to nonorganic (i.e., psychogenic) causes.	""	0	#FFFFFF
D001049	C08.618.085|C23.888.852.130	Apnea	A transient absence of spontaneous respiration.	""	0	#FFFFFF
D001063	C04.588.274.476.411.184.290|C06.301.371.411.184.290|C06.405.249.411.184.290|C06.405.469.110.417.290|C06.405.469.491.184.290	Appendiceal Neoplasms	Tumors or cancer of the APPENDIX.	""	0	#FFFFFF
D001064	C01.463.099|C06.405.205.099|C06.405.469.110.207	Appendicitis	Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.	""	0	#FFFFFF
D001072	C10.597.606.881.350|C23.888.592.604.882.350	Apraxias	A group of cognitive disorders characterized by the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function. The two major subtypes of this condition are ideomotor (see APRAXIA, IDEOMOTOR) and ideational apraxia, which refers to loss of the ability to mentally formulate the processes involved with performing an action. For example, dressing apraxia may result from an inability to mentally formulate the act of placing clothes on the body. Apraxias are generally associated with lesions of the dominant PARIETAL LOBE and supramarginal gyrus. (From Adams et al., Principles of Neurology, 6th ed, pp56-7)	""	0	#FFFFFF
D001079	C04.557.465.625.650.135|C04.557.470.035.250|C04.557.580.625.650.135	Apudoma	A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.	""	0	#FFFFFF
D001098	C25.723.127.723|C26.176.790	Spider Bites	The effects, both local and systemic, caused by the bites of SPIDERS.	""	0	#FFFFFF
D001100	C10.586.625.097	Arachnoiditis	Acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. This term generally refers to a persistent inflammatory process characterized by thickening of the ARACHNOID membrane and dural adhesions. Associated conditions include prior surgery, infections, trauma, SUBARACHNOID HEMORRHAGE, and chemical irritation. Clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (From Joynt, Clinical Neurology, 1997, Ch48, p25)	""	0	#FFFFFF
D001102	C01.920.500|C01.925.081	Arbovirus Infections	Infections caused by arthropod-borne viruses, general or unspecified.	""	0	#FFFFFF
D001112	C11.204.299.070	Arcus Senilis	A corneal disease in which there is a deposition of phospholipid and cholesterol in the corneal stroma and anterior sclera.	""	0	#FFFFFF
D001117	C01.925.782.082	Arenaviridae Infections	Virus diseases caused by the ARENAVIRIDAE.	""	0	#FFFFFF
D001129	C17.800.621.166|C25.723.522.313	Argyria	A permanent ashen-gray discoloration of the skin, conjunctiva, and internal organs resulting from long-continued use of silver salts. (Dorland, 27th ed)	""	0	#FFFFFF
D001134	C26.088	Arm Injuries	General or unspecified injuries involving the UPPER ARM and the FOREARM.	""	0	#FFFFFF
D001139	C10.500.680.291|C16.131.666.680.291	Arnold-Chiari Malformation	A group of congenital malformations involving the brainstem, cerebellum, upper spinal cord, and surrounding bony structures. Type II is the most common, and features compression of the medulla and cerebellar tonsils into the upper cervical spinal canal and an associated MENINGOMYELOCELE. Type I features similar, but less severe malformations and is without an associated meningomyelocele. Type III has the features of type II with an additional herniation of the entire cerebellum through the bony defect involving the foramen magnum, forming an ENCEPHALOCELE. Type IV is a form a cerebellar hypoplasia. Clinical manifestations of types I-III include TORTICOLLIS; opisthotonus; HEADACHE; VERTIGO; VOCAL CORD PARALYSIS; APNEA; NYSTAGMUS, CONGENITAL; swallowing difficulties; and ATAXIA. (From Menkes, Textbook of Child Neurology, 5th ed, p261; Davis, Textbook of Neuropathology, 2nd ed, pp236-46)	""	0	#FFFFFF
D001145	C14.280.067|C23.550.073	Arrhythmias, Cardiac	Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	""	0	#FFFFFF
D001146	C14.280.067.093|C23.550.073.093	Arrhythmia, Sinus	Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.	""	0	#FFFFFF
D001157	C14.907.137	Arterial Occlusive Diseases	Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.	""	0	#FFFFFF
D001159	C14.240.850.984.500|C14.907.933.110|C16.131.240.850.500|C23.300.575.950.150	Arterio-Arterial Fistula	Abnormal communication between two ARTERIES that may result from injury or occur as a congenital abnormality.	""	0	#FFFFFF
D001161	C14.907.137.126	Arteriosclerosis	Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.	""	0	#FFFFFF
D001162	C14.907.137.126.114	Arteriosclerosis Obliterans	Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.	""	0	#FFFFFF
D001164	C14.240.850.750.147|C14.240.850.984.750|C14.907.150.125|C14.907.933.555|C16.131.240.850.750.125|C23.300.575.950.250	Arteriovenous Fistula	An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.	""	0	#FFFFFF
D001165	C14.240.850.750|C14.907.150|C16.131.240.850.750	Arteriovenous Malformations	Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.	""	0	#FFFFFF
D001167	C14.907.940.090	Arteritis	INFLAMMATION of any ARTERIES.	""	0	#FFFFFF
D001168	C05.550.114	Arthritis	Acute or chronic inflammation of JOINTS.	""	0	#FFFFFF
D001169	C05.550.114.015	Arthritis, Experimental	ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.	""	0	#FFFFFF
D001170	C01.100|C05.550.114.099	Arthritis, Infectious	Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.	""	0	#FFFFFF
D001171	C05.550.114.122|C05.799.056|C17.300.775.049|C20.111.198	Arthritis, Juvenile	Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.	""	0	#FFFFFF
D001172	C05.550.114.154|C05.799.114|C17.300.775.099|C20.111.199	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	""	0	#FFFFFF
D001176	C05.550.150|C05.651.102|C05.660.077|C16.131.621.077	Arthrogryposis	Persistent flexure or contracture of a joint.	""	0	#FFFFFF
D001177	C05.550.186	Arthropathy, Neurogenic	Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)	""	0	#FFFFFF
D001183	C20.543.520.100	Arthus Reaction	A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.	""	0	#FFFFFF
D001184	C10.597.606.150.500.800.150|C23.888.592.604.150.500.800.150	Articulation Disorders	Disorders of the quality of speech characterized by the substitution, omission, distortion, and addition of phonemes.	""	0	#FFFFFF
D001195	C08.381.483.581.125|C08.381.520.702.125|C24.800.127	Asbestosis	A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.	""	0	#FFFFFF
D001196	C01.610.335.508.700.100.070	Ascariasis	Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.	""	0	#FFFFFF
D001198	C01.610.335.508.700.100.080	Ascaridiasis	Infection with nematodes of the genus ASCARIDIA. This condition usually occurs in fowl, often manifesting diarrhea.	""	0	#FFFFFF
D001201	C23.550.081	Ascites	Accumulation or retention of free fluid within the peritoneal cavity.	""	0	#FFFFFF
D001206	C18.654.521.500.133.115	Ascorbic Acid Deficiency	A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)	""	0	#FFFFFF
D001228	C01.150.703.080	Aspergillosis	Infections with fungi of the genus ASPERGILLUS.	""	0	#FFFFFF
D001229	C01.150.703.080.768.500|C01.150.703.534.850.500|C01.748.435.090|C08.381.472.850.500|C08.674.060|C08.730.435.090|C20.543.480.680.085	Aspergillosis, Allergic Bronchopulmonary	Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.	""	0	#FFFFFF
D001237	C23.550.260.095|C26.103	Asphyxia	A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.	""	0	#FFFFFF
D001238	C16.614.092	Asphyxia Neonatorum	Respiratory failure in the newborn. (Dorland, 27th ed)	""	0	#FFFFFF
D001247	C23.888.089	Asthenia	Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.	""	0	#FFFFFF
D001248	C11.093	Asthenopia	Term generally used to describe complaints related to refractive error, ocular muscle imbalance, including pain or aching around the eyes, burning and itchiness of the eyelids, ocular fatigue, and headaches.	""	0	#FFFFFF
D001249	C08.127.108|C08.381.495.108|C08.674.095|C20.543.480.680.095	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	""	0	#FFFFFF
D001250	C08.127.108.110|C08.674.095.110|C20.543.480.680.095.110	Asthma, Exercise-Induced	Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).	""	0	#FFFFFF
D001251	C11.744.212	Astigmatism	Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less diffuse area. This results from the radius of curvature in one plane being longer or shorter than the radius at right angles to it. (Dorland, 27th ed)	""	0	#FFFFFF
D001254	C04.557.465.625.600.380.080|C04.557.470.670.380.080|C04.557.580.625.600.380.080	Astrocytoma	Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)	""	0	#FFFFFF
D001259	C10.597.350.090|C23.888.592.350.090	Ataxia	Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.	""	0	#FFFFFF
D001260	C10.228.140.252.190.530.060|C10.562.100|C10.597.350.090.500.530.060|C14.907.823.213|C16.320.080|C16.320.798.250|C18.452.284.060|C20.673.795.250	Ataxia Telangiectasia	An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).	""	0	#FFFFFF
D001261	C08.381.730	Pulmonary Atelectasis	Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.	""	0	#FFFFFF
D001264	C10.597.350.110|C23.888.592.350.110	Athetosis	A dyskinesia characterized by an inability to maintain the fingers, toes, tongue, or other body parts in a stable position, resulting in continuous slow, sinusoidal, and flowing involuntary movements. This condition is frequently accompanied by CHOREA, where it is referred to as choreoathetosis. Athetosis may occur as a manifestation of BASAL GANGLIA DISEASES or DRUG TOXICITY. (From Adams et al., Principles of Neurology, 6th ed, p76)	""	0	#FFFFFF
D001265	C26.115	Athletic Injuries	Injuries incurred during participation in competitive or non-competitive sports.	""	0	#FFFFFF
D001281	C14.280.067.198|C23.550.073.198	Atrial Fibrillation	Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.	""	0	#FFFFFF
D001282	C14.280.067.248|C23.550.073.248	Atrial Flutter	Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).	""	0	#FFFFFF
D001284	C23.300.070	Atrophy	Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.	""	0	#FFFFFF
D001304	C09.218.807.186|C10.228.140.068	Auditory Diseases, Central	Disorders of hearing or auditory perception due to pathological processes of the AUDITORY PATHWAYS in the CENTRAL NERVOUS SYSTEM. These include CENTRAL HEARING LOSS and AUDITORY PERCEPTUAL DISORDERS.	""	0	#FFFFFF
D001308	C09.218.807.186.094|C10.228.140.068.094|C10.597.606.762.200|C23.888.592.604.764.200	Auditory Perceptual Disorders	Acquired or developmental cognitive disorders of AUDITORY PERCEPTION characterized by a reduced ability to perceive information contained in auditory stimuli despite intact auditory pathways. Affected individuals have difficulty with speech perception, sound localization, and comprehending the meaning of inflections of speech.	""	0	#FFFFFF
D001327	C20.111	Autoimmune Diseases	Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	""	0	#FFFFFF
D001329	C23.550.260.224.617.236	Autolysis	The spontaneous disintegration of tissues or cells by the action of their own autogenous enzymes.	""	0	#FFFFFF
D001342	C10.177	Autonomic Nervous System Diseases	Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.	""	0	#FFFFFF
D001353	C01.925.782.815.096|C01.925.928.120|C04.557.337.372.216|C04.619.531.216|C22.131.094	Avian Leukosis	A group of transmissible viral diseases of chickens and turkeys. Liver tumors are found in most forms, but tumors can be found elsewhere.	""	0	#FFFFFF
D001357	C01.925.782.815.800|C01.925.928.800|C04.557.450.795.830.800|C04.619.857.800|C22.131.800	Sarcoma, Avian	Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.	""	0	#FFFFFF
D001361	C18.654.521.500.133	Avitaminosis	A condition due to a deficiency of one or more essential vitamins. (Dorland, 27th ed)	""	0	#FFFFFF
D001404	C01.610.701.688.122|C01.610.752.075|C01.610.752.625.122|C01.920.930.182|C22.674.710.122	Babesiosis	A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.	""	0	#FFFFFF
D001416	C23.888.592.612.107	Back Pain	Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.	""	0	#FFFFFF
D001423	C01.150	Bacterial Infections and Mycoses	Infections caused by bacteria and fungi, general, specified, or unspecified.	""	0	#FFFFFF
D001424	C01.150.252	Bacterial Infections	Infections by bacteria, general or unspecified.	""	0	#FFFFFF
D001437	C01.915.219|C12.050.351.968.892.219|C12.200.777.892.219|C12.950.892.219	Bacteriuria	The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.	""	0	#FFFFFF
D001442	C01.150.252.400.110.109	Bacteroides Infections	Infections with bacteria of the genus BACTEROIDES.	""	0	#FFFFFF
D001446	C12.100.500.494.136|C12.200.294.494.136	Balanitis	Inflammation of the head of the PENIS, glans penis.	""	0	#FFFFFF
D001447	C01.610.432.146|C01.610.752.200.146|C06.405.469.452.146	Balantidiasis	Infection by parasites of the genus BALANTIDIUM. The presence of Balantidium in the LARGE INTESTINE leads to DIARRHEA; DYSENTERY; and occasionally ULCER.	""	0	#FFFFFF
D001449	C12.050.351.968.419.570.643.150|C12.200.777.419.570.643.150|C12.950.419.570.643.150	Balkan Nephropathy	A form of chronic interstitial nephritis that is endemic to limited areas of BULGARIA, the former YUGOSLAVIA, and ROMANIA. It is characterized by a progressive shrinking of the KIDNEYS that is often associated with uroepithelial tumors.	""	0	#FFFFFF
D001469	C26.120	Barotrauma	Injury following pressure changes; includes injury to the eustachian tube, ear drum, lung and stomach.	""	0	#FFFFFF
D001471	C04.834.154|C06.405.117.102	Barrett Esophagus	A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.	""	0	#FFFFFF
D001474	C01.150.252.400.126.100	Bartonella Infections	Infections by the genus BARTONELLA. Bartonella bacilliformis can cause acute febrile anemia, designated Oroya fever, and a benign skin eruption, called verruga peruana. BARTONELLA QUINTANA causes TRENCH FEVER, while BARTONELLA HENSELAE is the etiologic agent of bacillary angiomatosis (ANGIOMATOSIS, BACILLARY) and is also one of the causes of CAT-SCRATCH DISEASE.	""	0	#FFFFFF
D001476	C01.150.252.400.126	Bartonellaceae Infections	Infections with bacteria of the family BARTONELLACEAE.	""	0	#FFFFFF
D001477	C12.050.351.968.419.815.279|C12.200.777.419.815.279|C12.950.419.815.279|C19.053.800.604.249	Bartter Syndrome	A group of disorders caused by defective salt reabsorption in the ascending LOOP OF HENLE. It is characterized by severe salt-wasting, HYPOKALEMIA; HYPERCALCIURIA; metabolic ALKALOSIS, and hyper-reninemic HYPERALDOSTERONISM without HYPERTENSION. There are several subtypes including ones due to mutations in the renal specific SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.	""	0	#FFFFFF
D001478	C04.182.089.530.690.150|C04.557.470.200.165.150|C04.557.470.565.165.150|C04.700.175|C05.116.099.105|C05.500.470.690.150|C07.320.450.670.130|C16.131.077.130|C16.320.700.175	Basal Cell Nevus Syndrome	Hereditary disorder consisting of multiple basal cell carcinomas, odontogenic keratocysts, and multiple skeletal defects, e.g., frontal and temporoparietal bossing, bifurcated and splayed ribs, kyphoscoliosis, fusion of vertebrae, and cervicothoracic spina bifida. Genetic transmission is autosomal dominant.	""	0	#FFFFFF
D001480	C10.228.140.079	Basal Ganglia Diseases	Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.	""	0	#FFFFFF
D001506	C16.131.077.133|C16.131.260.080|C16.320.180.080	Beckwith-Wiedemann Syndrome	A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities.	""	0	#FFFFFF
D001528	C07.465.075|C11.941.879.780.880.200|C14.907.940.100|C16.320.382.250|C17.800.827.368.250|C17.800.862.150	Behcet Syndrome	Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.	""	0	#FFFFFF
D001602	C18.654.521.500.133.699.827.223	Beriberi	A disease caused by a deficiency of thiamine (vitamin B1) and characterized by polyneuritis, cardiac pathology, and edema. The epidemic form is found primarily in areas in which white (polished) rice is the staple food, as in Japan, China, the Philippines, India, and other countries of southeast Asia. (Dorland, 27th ed)	""	0	#FFFFFF
D001606	C15.378.100.100.080|C15.378.140.120|C15.378.463.080|C16.320.099.080	Bernard-Soulier Syndrome	A familial coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, and impaired prothrombin consumption.	""	0	#FFFFFF
D001607	C08.381.483.581.225|C08.381.520.702.225|C24.800.225	Berylliosis	A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.	""	0	#FFFFFF
D001630	C26.392.183	Bezoars	Concretions of swallowed hair, fruit or vegetable fibers, or similar substances found in the alimentary canal.	""	0	#FFFFFF
D001649	C06.130.120	Bile Duct Diseases	Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.	""	0	#FFFFFF
D001650	C04.588.274.120.250|C06.130.120.120|C06.130.320.120|C06.301.120.250	Bile Duct Neoplasms	Tumors or cancer of the BILE DUCTS.	""	0	#FFFFFF
D001651	C06.130.120.135.150	Cholestasis, Extrahepatic	Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.	""	0	#FFFFFF
D001655	C06.130.140|C06.405.748.240.140	Bile Reflux	Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.	""	0	#FFFFFF
D001656	C06.130.120.123|C06.198.125|C16.131.314.125	Biliary Atresia	Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.	""	0	#FFFFFF
D001657	C06.130.120.250.098	Biliary Dyskinesia	A motility disorder characterized by biliary COLIC, absence of GALLSTONES, and an abnormal GALLBLADDER ejection fraction. It is caused by gallbladder dyskinesia and/or SPHINCTER OF ODDI DYSFUNCTION.	""	0	#FFFFFF
D001658	C06.267.150|C23.300.575.185.150	Biliary Fistula	Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.	""	0	#FFFFFF
D001660	C06.130	Biliary Tract Diseases	Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.	""	0	#FFFFFF
D001661	C04.588.274.120|C06.130.320|C06.301.120	Biliary Tract Neoplasms	Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.	""	0	#FFFFFF
D001715	C22.131	Bird Diseases	Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc.	""	0	#FFFFFF
D001716	C08.381.483.125.125|C08.674.055.125|C20.543.480.680.075.125|C24.125	Bird Fancier's Lung	A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.	""	0	#FFFFFF
D001720	C16.614.131|C26.141	Birth Injuries	Mechanical or anoxic trauma incurred by the infant during labor or delivery.	""	0	#FFFFFF
D001724	C23.888.144.186	Birth Weight	The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.	""	0	#FFFFFF
D001733	C25.723.127|C26.176	Bites and Stings	Injuries inflicted by the TEETH or poisoning caused by VENOMS of animals.	""	0	#FFFFFF
D001734	C26.176.071	Bites, Human	Bites inflicted by humans.	""	0	#FFFFFF
D001742	C01.610.752.530.650.228|C01.920.875.650.228	Blackwater Fever	A complication of MALARIA, FALCIPARUM characterized by the passage of dark red to black urine.	""	0	#FFFFFF
D001744	C12.050.351.968.829.521|C12.050.351.968.967.500.925|C12.200.777.829.720|C12.200.777.967.500.925|C12.950.829.521|C12.950.967.500.925|C23.300.175.850.875	Urinary Bladder Calculi	Stones in the URINARY BLADDER; also known as vesical calculi, bladder stones, or cystoliths.	""	0	#FFFFFF
D001745	C12.050.351.968.829|C12.200.777.829|C12.950.829	Urinary Bladder Diseases	Pathological processes of the URINARY BLADDER.	""	0	#FFFFFF
D001746	C12.050.351.875.132|C12.050.351.968.829.132|C12.200.706.132|C12.200.777.829.132|C12.800.132|C12.950.829.132|C16.131.939.132	Bladder Exstrophy	A birth defect in which the URINARY BLADDER is malformed and exposed, inside out, and protruded through the ABDOMINAL WALL. It is caused by closure defects involving the top front surface of the bladder, as well as the lower abdominal wall; SKIN; MUSCLES; and the pubic bone.	""	0	#FFFFFF
D001747	C12.050.351.875.881.312|C12.050.351.968.829.548|C12.200.706.881.312|C12.200.777.829.733|C12.800.881.312|C12.950.829.548|C23.300.575.825.250	Urinary Bladder Fistula	An abnormal passage in the URINARY BLADDER or between the bladder and any surrounding organ.	""	0	#FFFFFF
D001748	C12.050.351.968.767.700.850|C12.050.351.968.829.601|C12.200.777.767.700.962|C12.200.777.829.760|C12.950.767.700.850|C12.950.829.601	Urinary Bladder Neck Obstruction	Blocked urine flow through the bladder neck, the narrow internal urethral opening at the base of the URINARY BLADDER. Narrowing or strictures of the URETHRA can be congenital or acquired. It is often observed in males with enlarged PROSTATE glands.	""	0	#FFFFFF
D001749	C04.588.945.947.960|C12.050.351.937.820.945|C12.050.351.968.829.707|C12.200.758.820.968|C12.200.777.829.813|C12.900.820.945|C12.950.829.707|C12.950.983.945	Urinary Bladder Neoplasms	Tumors or cancer of the URINARY BLADDER.	""	0	#FFFFFF
D001750	C10.597.900|C12.050.351.968.829.760|C12.200.777.829.839|C12.950.829.760|C23.888.592.900	Urinary Bladder, Neurogenic	Dysfunction of the URINARY BLADDER due to disease of the central or peripheral nervous system pathways involved in the control of URINATION. This is often associated with SPINAL CORD DISEASES, but may also be caused by BRAIN DISEASES or PERIPHERAL NERVE DISEASES.	""	0	#FFFFFF
D001752	C04.557.337.539.250.100|C04.697.098.500.110|C15.378.190.636.370.100|C23.550.291.500.485.100|C23.550.727.098.500.110	Blast Crisis	An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.	""	0	#FFFFFF
D001753	C26.120.126	Blast Injuries	Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)	""	0	#FFFFFF
D001759	C01.150.703.302.055|C01.150.703.534.350|C01.748.435.395|C01.800.200.055|C08.381.472.350|C08.730.435.395|C17.800.838.208.055	Blastomycosis	A fungal infection that may appear in two forms: 1, a primary lesion characterized by the formation of a small cutaneous nodule and small nodules along the lymphatics that may heal within several months; and 2, chronic granulomatous lesions characterized by thick crusts, warty growths, and unusual vascularity and infection in the middle or upper lobes of the lung.	""	0	#FFFFFF
D001762	C11.338.133	Blepharitis	Inflammation of the eyelids.	""	0	#FFFFFF
D001763	C11.338.204	Blepharoptosis	Drooping of the upper lid due to deficient development or paralysis of the levator palpebrae muscle.	""	0	#FFFFFF
D001764	C11.338.250	Blepharospasm	Excessive winking; tonic or clonic spasm of the orbicularis oculi muscle.	""	0	#FFFFFF
D001765	C06.405.469.637.145|C18.452.603.145	Blind Loop Syndrome	A malabsorption syndrome that is associated with a blind loop in the upper SMALL INTESTINE that is characterized by the lack of peristaltic movement, stasis of INTESTINAL CONTENTS, and the overgrowth of BACTERIA. Such bacterial overgrowth interferes with BILE SALTS action, FATTY ACIDS processing, MICROVILLI integrity, and the ABSORPTION of nutrients such as VITAMIN B12 and FOLIC ACID.	""	0	#FFFFFF
D001766	C10.597.751.941.162|C11.966.075|C23.888.592.763.941.162	Blindness	The inability to see or the loss or absence of perception of visual stimuli. This condition may be the result of EYE DISEASES; OPTIC NERVE DISEASES; OPTIC CHIASM diseases; or BRAIN DISEASES affecting the VISUAL PATHWAYS or OCCIPITAL LOBE.	""	0	#FFFFFF
D001768	C17.800.865.187|C23.300.122	Blister	Visible accumulations of fluid within or beneath the epidermis.	""	0	#FFFFFF
D001778	C15.378.100	Blood Coagulation Disorders	Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.	""	0	#FFFFFF
D001791	C15.378.140	Blood Platelet Disorders	Disorders caused by abnormalities in platelet count or function.	""	0	#FFFFFF
D001796	C15.378.147	Blood Protein Disorders	Hematologic diseases caused by structural or functional defects of BLOOD PROTEINS.	""	0	#FFFFFF
D001816	C16.131.077.137|C16.320.798.313|C18.452.284.100|C20.673.795.313	Bloom Syndrome	An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.	""	0	#FFFFFF
D001819	C01.920.500.125|C01.925.081.125|C01.925.782.791.315|C22.836.120	Bluetongue	A reovirus infection, chiefly of sheep, characterized by a swollen blue tongue, catarrhal inflammation of upper respiratory and gastrointestinal tracts, and often by inflammation of sensitive laminae of the feet and coronet.	""	0	#FFFFFF
D001832	C23.888.119	Body Temperature Changes	Significant alterations in temperature of the human body, above or below 98.6 degrees F. or 37 degrees C. when taken orally.	""	0	#FFFFFF
D001835	C23.888.144	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	""	0	#FFFFFF
D001836	C23.888.144.243	Body Weight Changes	A clinical manifestation consisting of alterations in an individual's weight from his or her norm.	""	0	#FFFFFF
D001845	C04.182.089|C05.116.070	Bone Cysts	Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.	""	0	#FFFFFF
D001847	C05.116	Bone Diseases	Diseases of BONES.	""	0	#FFFFFF
D001848	C05.116.099	Bone Diseases, Developmental	Diseases resulting in abnormal GROWTH or abnormal MORPHOGENESIS of BONES.	""	0	#FFFFFF
D001849	C05.116.132|C19.149	Bone Diseases, Endocrine	Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.	""	0	#FFFFFF
D001850	C01.160|C05.116.165	Bone Diseases, Infectious	Bone diseases caused by pathogenic microorganisms.	""	0	#FFFFFF
D001851	C05.116.198|C18.452.104	Bone Diseases, Metabolic	Diseases that affect the METABOLIC PROCESSES of BONE TISSUE.	""	0	#FFFFFF
D001855	C15.378.190	Bone Marrow Diseases	Diseases involving the BONE MARROW.	""	0	#FFFFFF
D001859	C04.588.149|C05.116.231	Bone Neoplasms	Tumors or cancer located in bone tissue or specific BONES.	""	0	#FFFFFF
D001862	C05.116.264	Bone Resorption	Bone loss due to osteoclastic activity.	""	0	#FFFFFF
D001882	C01.925.782.350.675.100|C22.836.160	Border Disease	Congenital disorder of lambs caused by a virus closely related to or identical with certain strains of bovine viral diarrhea virus.	""	0	#FFFFFF
D001885	C01.150.252.400.143	Bordetella Infections	Infections with bacteria of the genus BORDETELLA.	""	0	#FFFFFF
D001890	C01.925.782.580.124|C22.152	Borna Disease	An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.	""	0	#FFFFFF
D001899	C01.150.252.400.794.352	Borrelia Infections	Infections with bacteria of the genus BORRELIA.	""	0	#FFFFFF
D001906	C01.150.252.410.222.151|C10.668.758.200|C10.720.150|C25.723.415.151	Botulism	A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)	""	0	#FFFFFF
D001907	C01.150.252.400.789.725.400.250|C01.920.930.887.250	Boutonneuse Fever	A febrile disease of the Mediterranean area, the Crimea, Africa, and India, caused by infection with RICKETTSIA CONORII.	""	0	#FFFFFF
D001912	C01.925.782.350.675.106|C22.196.106	Bovine Virus Diarrhea-Mucosal Disease	Acute disease of cattle caused by the bovine viral diarrhea viruses (DIARRHEA VIRUSES, BOVINE VIRAL). Often mouth ulcerations are the only sign but fever, diarrhea, drop in milk yield, and loss of appetite are also seen. Severity of clinical disease varies and is strain dependent. Outbreaks are characterized by low morbidity and high mortality.	""	0	#FFFFFF
D001913	C04.557.470.200.400.130|C04.557.470.700.400.130	Bowen's Disease	A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)	""	0	#FFFFFF
D001919	C14.280.067.319|C23.550.073.300	Bradycardia	Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.	""	0	#FFFFFF
D001922	C01.207.090|C01.830.025.160|C10.228.140.116|C10.228.228.090	Brain Abscess	A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)	""	0	#FFFFFF
D001924	C10.228.140.199.444.250|C10.900.300.087.235.250|C10.900.300.350.300|C26.915.300.200.194.250|C26.915.300.450.500|C26.974.382.200	Brain Concussion	A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418)	""	0	#FFFFFF
D001925	C10.228.140.140|C23.550.291.500.063	Brain Damage, Chronic	A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.	""	0	#FFFFFF
D001926	C10.228.140.151|C10.597.606.358.800.200.100|C23.550.260.159	Brain Death	A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)	""	0	#FFFFFF
D001927	C10.228.140	Brain Diseases	Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	""	0	#FFFFFF
D001928	C10.228.140.163|C18.452.132	Brain Diseases, Metabolic	Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.	""	0	#FFFFFF
D001929	C10.228.140.187	Brain Edema	Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)	""	0	#FFFFFF
D001930	C10.228.140.199|C10.900.300.087|C26.915.300.200	Brain Injuries	Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.	""	0	#FFFFFF
D001932	C04.588.614.250.195|C10.228.140.211|C10.551.240.250	Brain Neoplasms	Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	""	0	#FFFFFF
D001935	C04.182.117	Branchioma	A tumor derived from branchial epithelium or branchial rests. (Dorland, 27th ed)	""	0	#FFFFFF
D001941	C17.800.090	Breast Diseases	Pathological processes of the BREAST.	""	0	#FFFFFF
D001943	C04.588.180|C17.800.090.500	Breast Neoplasms	Tumors or cancer of the human BREAST.	""	0	#FFFFFF
D001946	C12.050.703.420.183	Breech Presentation	A malpresentation of the FETUS at near term or during OBSTETRIC LABOR with the fetal cephalic pole in the fundus of the UTERUS. There are three types of breech: the complete breech with flexed hips and knees; the incomplete breech with one or both hips partially or fully extended; the frank breech with flexed hips and extended knees.	""	0	#FFFFFF
D001948	C04.557.450.565.590.595.150|C04.557.470.625.150|C12.050.351.500.056.630.705.265|C12.050.351.937.418.685.265|C12.100.250.056.630.705.265|C12.900.418.685.265|C19.391.630.705.265	Brenner Tumor	A smooth, solid or cystic fibroepithelial (FIBROEPITHELIAL NEOPLASMS) tumor, usually found in the OVARIES but can also be found in the adnexal region and the KIDNEYS. It consists of a fibrous stroma with nests of epithelial cells that sometimes resemble the transitional cells lining the urinary bladder. Brenner tumors generally are benign and asymptomatic. Malignant Brenner tumors have been reported.	""	0	#FFFFFF
D001982	C08.127	Bronchial Diseases	Diseases involving the BRONCHI.	""	0	#FFFFFF
D001983	C08.127.196|C08.702.196|C23.300.575.687.225	Bronchial Fistula	An abnormal passage or communication between a bronchus and another part of the body.	""	0	#FFFFFF
D001984	C04.588.894.797.520.109|C08.127.265|C08.785.520.100	Bronchial Neoplasms	Tumors or cancer of the BRONCHI.	""	0	#FFFFFF
D001986	C08.127.321	Bronchial Spasm	Spasmodic contraction of the smooth muscle of the bronchi.	""	0	#FFFFFF
D001987	C08.127.384	Bronchiectasis	Persistent abnormal dilatation of the bronchi.	""	0	#FFFFFF
D001988	C01.748.099.135|C08.127.446.135|C08.381.495.146.135|C08.730.099.135	Bronchiolitis	Inflammation of the BRONCHIOLES.	""	0	#FFFFFF
D001989	C08.127.446.135.140|C08.381.495.146.135.140	Bronchiolitis Obliterans	Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.	""	0	#FFFFFF
D001990	C01.748.099.135.321|C01.925.109|C08.127.446.135.321|C08.381.495.146.135.321|C08.730.099.135.321	Bronchiolitis, Viral	An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.	""	0	#FFFFFF
D001991	C01.748.099|C08.127.446|C08.381.495.146|C08.730.099	Bronchitis	Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.	""	0	#FFFFFF
D001994	C04.182.195|C08.127.480|C08.695.195|C16.131.740.195	Bronchogenic Cyst	A usually spherical cyst, arising as an embryonic out-pouching of the foregut or trachea. It is generally found in the mediastinum or lung and is usually asymptomatic unless it becomes infected.	""	0	#FFFFFF
D001996	C01.748.610.127|C08.127.509|C08.381.677.127|C08.730.610.127	Bronchopneumonia	Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.	""	0	#FFFFFF
D001997	C08.381.520.750.500|C16.614.521.125	Bronchopulmonary Dysplasia	A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.	""	0	#FFFFFF
D001998	C08.695.214|C16.131.740.214	Bronchopulmonary Sequestration	A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.	""	0	#FFFFFF
D002006	C01.150.252.400.167	Brucellosis	Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.	""	0	#FFFFFF
D002007	C01.150.252.400.167.322|C22.021.322|C22.196.148	Brucellosis, Bovine	A disease of cattle caused by bacteria of the genus BRUCELLA leading to abortion in late pregnancy. BRUCELLA ABORTUS is the primary infective agent.	""	0	#FFFFFF
D002012	C07.793.099	Bruxism	A disorder characterized by grinding and clenching of the teeth.	""	0	#FFFFFF
D002032	C23.888.821.645.500	Bulimia	"Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as ""ox hunger""."	""	0	#FFFFFF
D002037	C14.280.067.558.323|C14.280.123.500.323|C23.550.073.425.100	Bundle-Branch Block	A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.	""	0	#FFFFFF
D002044	C01.925.782.147	Bunyaviridae Infections	Virus diseases caused by the BUNYAVIRIDAE.	""	0	#FFFFFF
D002051	C01.925.256.466.313.165|C01.925.928.313.165|C04.557.386.480.150.165|C15.604.515.569.480.150.165|C20.683.515.761.480.150.165	Burkitt Lymphoma	A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.	""	0	#FFFFFF
D002054	C07.465.114	Burning Mouth Syndrome	A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.	""	0	#FFFFFF
D002055	C24.580.500	Burnout, Professional	An excessive stress reaction to one's occupational or professional environment. It may be characterized by feelings of emotional and physical exhaustion, coupled with a sense of frustration and failure.	""	0	#FFFFFF
D002056	C26.200	Burns	Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.	""	0	#FFFFFF
D002057	C26.200.156	Burns, Chemical	Burns caused by contact with or exposure to CAUSTICS or strong ACIDS.	""	0	#FFFFFF
D002058	C26.200.239|C26.324.323	Burns, Electric	Burns produced by contact with electric current or from a sudden discharge of electricity.	""	0	#FFFFFF
D002059	C26.200.322	Burns, Inhalation	Burns of the respiratory tract caused by heat or inhaled chemicals.	""	0	#FFFFFF
D002062	C05.550.251	Bursitis	Inflammation or irritation of a SYNOVIAL BURSA, the fibrous sac that acts as a cushion between moving structures of bones, muscles, tendons or skin.	""	0	#FFFFFF
D002095	C08.381.483.581.275|C08.381.520.702.275|C24.800.323	Byssinosis	A condition of BRONCHOCONSTRICTION resulting from hypersensitive reaction to inhaled dust during the initial processing of cotton, flax, or hemp in the textile industry. Symptoms include wheezing and tightness in the chest.	""	0	#FFFFFF
D002100	C23.888.144.243.963.500.500	Cachexia	General ill health, malnutrition, and weight loss, usually associated with chronic disease.	""	0	#FFFFFF
D002102	C23.550.260.224	Cadaver	A dead body, usually a human body.	""	0	#FFFFFF
D002105	C25.723.522.625	Cadmium Poisoning	Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.	""	0	#FFFFFF
D002114	C18.452.174.130	Calcinosis	Pathologic deposition of calcium salts in tissues.	""	0	#FFFFFF
D002115	C18.452.174.130.186	Calciphylaxis	Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.	""	0	#FFFFFF
D002128	C18.452.174	Calcium Metabolism Disorders	Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.	""	0	#FFFFFF
D002137	C23.300.175	Calculi	An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.	""	0	#FFFFFF
D002145	C17.800.428.200	Callosities	Localized hyperplasia of the horny layer of the epidermis due to pressure or friction. (Dorland, 27th ed)	""	0	#FFFFFF
D002169	C01.150.252.400.177	Campylobacter Infections	Infections with bacteria of the genus CAMPYLOBACTER.	""	0	#FFFFFF
D002177	C01.150.703.160	Candidiasis	Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	""	0	#FFFFFF
D002178	C01.150.703.160.088|C01.150.703.302.100|C01.800.200.100|C17.800.838.208.165|C23.550.291.500.250	Candidiasis, Chronic Mucocutaneous	A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.	""	0	#FFFFFF
D002179	C01.150.703.160.132|C01.150.703.302.105|C01.800.200.105|C17.800.838.208.170	Candidiasis, Cutaneous	Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)	""	0	#FFFFFF
D002180	C01.150.703.160.180|C07.465.130	Candidiasis, Oral	Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)	""	0	#FFFFFF
D002181	C01.150.703.160.190|C12.050.351.500.894.906.820.500|C12.050.351.500.944.902.737.500|C12.100.250.894.906.820.500|C12.100.250.944.902.737.500	Candidiasis, Vulvovaginal	Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.	""	0	#FFFFFF
D002189	C25.775.635	Marijuana Abuse	Use of marijuana associated with abnormal psychological, social, and or occupational functioning.	""	0	#FFFFFF
D002205	C05.550.114.154.219|C05.799.114.219|C08.381.483.581.300|C08.381.520.702.300|C17.300.775.099.219|C24.800.340	Caplan Syndrome	A condition characterized by the presence of RHEUMATOID ARTHRITIS associated with a specific form of pneumoconiosis, often in coal miners and asbestos workers.	""	0	#FFFFFF
D002239	C16.320.565.202|C18.452.648.202	Carbohydrate Metabolism, Inborn Errors	Dysfunctions of CARBOHYDRATE METABOLISM resulting from inborn genetic mutations that are inherited or acquired in utero.	""	0	#FFFFFF
D002249	C25.723.455.245	Carbon Monoxide Poisoning	Toxic asphyxiation due to the displacement of oxygen from oxyhemoglobin by carbon monoxide.	""	0	#FFFFFF
D002252	C25.723.177	Carbon Tetrachloride Poisoning	Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	""	0	#FFFFFF
D002270	C01.150.252.410.868.951.270.200|C01.150.252.819.770.270.200|C01.800.720.770.270.200|C17.800.838.765.770.270.200	Carbuncle	An infection of cutaneous and subcutaneous tissue that consists of a cluster of boils. Commonly, the causative agent is STAPHYLOCOCCUS AUREUS. Carbuncles produce fever, leukocytosis, extreme pain, and prostration.	""	0	#FFFFFF
D002275	C04.557.465.625.650.200.500.205|C04.557.470.200.025.200.500.205|C04.557.580.625.650.200.500.205|C14.280.104	Carcinoid Heart Disease	Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.	""	0	#FFFFFF
D002276	C04.557.465.625.650.200|C04.557.470.200.025.200|C04.557.580.625.650.200	Carcinoid Tumor	A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)	""	0	#FFFFFF
D002277	C04.557.470.200	Carcinoma	"A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for ""cancer."""	""	0	#FFFFFF
D002278	C04.557.470.200.240	Carcinoma in Situ	A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.	""	0	#FFFFFF
D002279	C04.557.435.290.210|C04.557.450.795.290.210|C04.619.045	Carcinoma 256, Walker	A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)	""	0	#FFFFFF
D002280	C04.557.470.200.165|C04.557.470.565.165	Carcinoma, Basal Cell	A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)	""	0	#FFFFFF
D002281	C04.557.470.200.170|C04.557.470.565.170	Carcinoma, Basosquamous	A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)	""	0	#FFFFFF
D002282	C04.557.470.200.025.022.500|C04.588.894.797.520.055.500	Adenocarcinoma, Bronchiolo-Alveolar	A carcinoma derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)	""	0	#FFFFFF
D002283	C04.588.894.797.520.109.220|C08.381.540.140|C08.785.520.100.220	Carcinoma, Bronchogenic	Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.	""	0	#FFFFFF
D002284	C04.619.124	Carcinoma, Brown-Pearce	A transplantable EPITHELIAL CELL neoplasm of rabbits.	""	0	#FFFFFF
D002285	C04.557.470.200.025.275|C04.557.470.200.240.187.250|C04.557.470.615.275	Carcinoma, Intraductal, Noninfiltrating	A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.	""	0	#FFFFFF
D002286	C04.557.470.200.200|C04.619.169	Carcinoma, Ehrlich Tumor	A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	""	0	#FFFFFF
D002287	C04.557.470.200.255|C04.619.214	Carcinoma, Krebs 2	A transplantable neoplasm of mice.	""	0	#FFFFFF
D002288	C04.557.470.200.025.075|C04.557.470.590.075	Adenocarcinoma, Mucinous	An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)	""	0	#FFFFFF
D002289	C04.588.894.797.520.109.220.249|C08.381.540.140.500|C08.785.520.100.220.500	Carcinoma, Non-Small-Cell Lung	A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	""	0	#FFFFFF
D002291	C04.557.470.200.360|C04.557.470.700.360	Carcinoma, Papillary	A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)	""	0	#FFFFFF
D002292	C04.557.470.200.025.390|C04.588.945.947.535.160|C12.050.351.937.820.535.160|C12.050.351.968.419.473.160|C12.200.758.820.750.160|C12.200.777.419.473.160|C12.900.820.535.160|C12.950.419.473.160|C12.950.983.535.160	Carcinoma, Renal Cell	A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	""	0	#FFFFFF
D002293	C04.557.470.200.025.095	Adenocarcinoma, Scirrhous	An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)	""	0	#FFFFFF
D002294	C04.557.470.200.400|C04.557.470.700.400	Carcinoma, Squamous Cell	A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	""	0	#FFFFFF
D002295	C04.557.470.200.430	Carcinoma, Transitional Cell	A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.	""	0	#FFFFFF
D002296	C04.557.435.290|C04.557.450.795.290	Carcinosarcoma	A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)	""	0	#FFFFFF
D002303	C14.280.148|C23.888.192	Cardiac Output, Low	A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.	""	0	#FFFFFF
D002305	C14.280.155	Cardiac Tamponade	Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.	""	0	#FFFFFF
D002310	C14.280.238.057|C25.775.100.087.250	Cardiomyopathy, Alcoholic	Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).	""	0	#FFFFFF
D002311	C14.280.195.160|C14.280.238.070|C16.320.488.750	Cardiomyopathy, Dilated	A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.	""	0	#FFFFFF
D002312	C14.280.238.100|C14.280.484.048.750.070.160	Cardiomyopathy, Hypertrophic	A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).	""	0	#FFFFFF
D002313	C14.280.238.160	Cardiomyopathy, Restrictive	A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.	""	0	#FFFFFF
D002318	C14	Cardiovascular Diseases	Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	""	0	#FFFFFF
D002340	C10.228.140.300.200|C14.907.253.123	Carotid Artery Diseases	Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.	""	0	#FFFFFF
D002341	C10.228.140.300.200.355|C14.907.253.123.355|C14.907.253.566.206|C14.907.355.590.213.206	Carotid Artery Thrombosis	Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.	""	0	#FFFFFF
D002345	C04.557.465.625.650.700.705.220|C04.557.580.625.650.700.705.220	Carotid Body Tumor	Benign paraganglioma at the bifurcation of the COMMON CAROTID ARTERIES. It can encroach on the parapharyngeal space and produce dysphagia, pain, and cranial nerve palsies.	""	0	#FFFFFF
D002349	C10.668.829.500.500.200|C10.668.829.550.200|C26.844.150.206	Carpal Tunnel Syndrome	Entrapment of the MEDIAN NERVE in the carpal tunnel, which is formed by the flexor retinaculum and the CARPAL BONES. This syndrome may be associated with repetitive occupational trauma (CUMULATIVE TRAUMA DISORDERS); wrist injuries; AMYLOID NEUROPATHIES; rheumatoid arthritis (see ARTHRITIS, RHEUMATOID); ACROMEGALY; PREGNANCY; and other conditions. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. (Joynt, Clinical Neurology, 1995, Ch51, p45)	""	0	#FFFFFF
D002357	C05.182|C17.300.182	Cartilage Diseases	Pathological processes involving the chondral tissue (CARTILAGE).	""	0	#FFFFFF
D002371	C22.180	Cat Diseases	Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.	""	0	#FFFFFF
D002372	C01.150.252.400.126.100.150|C15.604.315.249	Cat-Scratch Disease	A self-limiting bacterial infection of the regional lymph nodes caused by AFIPIA felis, a gram-negative bacterium recently identified by the Centers for Disease Control and Prevention and by BARTONELLA HENSELAE. It usually arises one or more weeks following a feline scratch, with raised inflammatory nodules at the site of the scratch being the primary symptom.	""	0	#FFFFFF
D002375	C10.597.350.200|C23.888.592.350.200	Catalepsy	A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.	""	0	#FFFFFF
D002385	C10.886.425.800.200.750.500	Cataplexy	A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)	""	0	#FFFFFF
D002386	C11.510.245	Cataract	Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)	""	0	#FFFFFF
D002388	C23.550.291.250	Catastrophic Illness	An acute or prolonged illness usually considered to be life-threatening or with the threat of serious residual disability. Treatment may be radical and is frequently costly.	""	0	#FFFFFF
D002389	C10.597.606.115|C23.888.592.604.115	Catatonia	A neuropsychiatric disorder characterized by one or more of the following essential features: immobility, mutism, negativism (active or passive refusal to follow commands), mannerisms, stereotypies, posturing, grimacing, excitement, echolalia, echopraxia, muscular rigidity, and stupor; sometimes punctuated by sudden violent outbursts, panic, or hallucinations. This condition may be associated with psychiatric illnesses (e.g., SCHIZOPHRENIA; MOOD DISORDERS) or organic disorders (NEUROLEPTIC MALIGNANT SYNDROME; ENCEPHALITIS, etc.). (From DSM-IV, 4th ed, 1994; APA, Thesaurus of Psychological Index Terms, 1994)	""	0	#FFFFFF
D002418	C22.196	Cattle Diseases	Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.	""	0	#FFFFFF
D002422	C10.177.195.200|C10.668.829.250.200|C10.668.829.600.200	Causalgia	A complex regional pain syndrome characterized by burning pain and marked sensitivity to touch (HYPERESTHESIA) in the distribution of an injured peripheral nerve. Autonomic dysfunction in the form of sudomotor (i.e., sympathetic innervation to sweat glands), vasomotor, and trophic skin changes may also occur. (Adams et al., Principles of Neurology, 6th ed, p1359)	""	0	#FFFFFF
D002429	C06.405.469.110	Cecal Diseases	Pathological developments in the CECUM.	""	0	#FFFFFF
D002430	C04.588.274.476.411.184|C06.301.371.411.184|C06.405.249.411.184|C06.405.469.110.417|C06.405.469.491.184	Cecal Neoplasms	Tumors or cancer of the CECUM.	""	0	#FFFFFF
D002446	C06.405.469.637.250|C18.452.603.250	Celiac Disease	A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.	""	0	#FFFFFF
D002471	C04.697.098.500|C23.550.727.098.500	Cell Transformation, Neoplastic	Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	""	0	#FFFFFF
D002472	C04.697.098.500.160|C23.550.727.098.500.160	Cell Transformation, Viral	An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.	""	0	#FFFFFF
D002481	C01.800.130|C01.830.200|C17.300.185|C23.550.470.756.200	Cellulitis	An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.	""	0	#FFFFFF
D002485	C04.557.695.210	Cementoma	An odontogenic fibroma in which cells have developed into cementoblasts and which consists largely of cementum.	""	0	#FFFFFF
D002493	C10.228	Central Nervous System Diseases	Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	""	0	#FFFFFF
D002494	C01.207|C10.228.228	Central Nervous System Infections	Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.	""	0	#FFFFFF
D002524	C10.228.140.252.190|C10.597.350.090.500|C23.888.592.350.090.200	Cerebellar Ataxia	Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)	""	0	#FFFFFF
D002526	C10.228.140.252	Cerebellar Diseases	Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.	""	0	#FFFFFF
D002527	C10.228.140.252.700.250|C10.228.854.787.500|C10.574.500.825.250|C16.320.400.780.500	Myoclonic Cerebellar Dyssynergia	A condition marked by progressive CEREBELLAR ATAXIA combined with MYOCLONUS usually presenting in the third decade of life or later. Additional clinical features may include generalized and focal SEIZURES, spasticity, and DYSKINESIAS. Autosomal recessive and autosomal dominant patterns of inheritance have been reported. Pathologically, the dentate nucleus and brachium conjunctivum of the CEREBELLUM are atrophic, with variable involvement of the spinal cord, cerebellar cortex, and basal ganglia. (From Joynt, Clinical Neurology, 1991, Ch37, pp60-1)	""	0	#FFFFFF
D002528	C04.588.614.250.195.411.211|C10.228.140.211.500.200|C10.228.140.252.200|C10.551.240.250.400.300	Cerebellar Neoplasms	Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)	""	0	#FFFFFF
D002532	C10.228.140.300.510.600|C14.907.055.635|C14.907.253.560.300	Intracranial Aneurysm	Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)	""	0	#FFFFFF
D002534	C10.228.140.624|C23.888.852.079.797	Hypoxia, Brain	A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.	""	0	#FFFFFF
D002537	C10.228.140.300.510.800|C14.907.137.126.372|C14.907.253.560.350	Intracranial Arteriosclerosis	Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.	""	0	#FFFFFF
D002538	C10.228.140.300.520|C10.500.190.500|C14.240.850.750.295|C14.240.850.875.500|C14.907.150.295|C14.907.253.560.400|C16.131.240.850.750.295|C16.131.240.850.875.500|C16.131.666.190.500	Intracranial Arteriovenous Malformations	Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.	""	0	#FFFFFF
D002539	C10.228.140.300.510.200|C14.907.253.560.200	Cerebral Arterial Diseases	Pathological conditions of intracranial ARTERIES supplying the CEREBRUM. These diseases often are due to abnormalities or pathological processes in the ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; and POSTERIOR CEREBRAL ARTERY.	""	0	#FFFFFF
D002542	C10.228.140.300.525|C14.907.253.566|C14.907.355.590.213	Intracranial Embolism and Thrombosis	Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.	""	0	#FFFFFF
D002543	C10.228.140.300.535.200|C14.907.253.573.200|C23.550.414.913.100	Cerebral Hemorrhage	Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.	""	0	#FFFFFF
D002544	C10.228.140.300.150.477.200|C10.228.140.300.775.200.200|C14.907.253.092.477.200|C14.907.253.855.200.200|C23.550.513.355.250.200|C23.550.717.489.250.200	Cerebral Infarction	The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).	""	0	#FFFFFF
D002545	C10.228.140.300.150|C14.907.253.092	Brain Ischemia	Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	""	0	#FFFFFF
D002546	C10.228.140.300.150.836|C14.907.253.092.836	Ischemic Attack, Transient	Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)	""	0	#FFFFFF
D002547	C10.228.140.140.254	Cerebral Palsy	A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)	""	0	#FFFFFF
D002549	C10.114.375.112|C10.228.140.400|C10.228.140.695.562.112|C10.314.350.112|C20.111.258.250.175	Diffuse Cerebral Sclerosis of Schilder	A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4-5):267-73)	""	0	#FFFFFF
D002551	C04.588.614.250.195.205|C10.228.140.211.280|C10.551.240.250.200	Cerebral Ventricle Neoplasms	Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.	""	0	#FFFFFF
D002558	C10.597.114.500|C10.900.300.109.500|C23.888.592.114.249|C26.915.300.225.500	Cerebrospinal Fluid Otorrhea	Discharge of cerebrospinal fluid through the external auditory meatus or through the eustachian tube into the nasopharynx. This is usually associated with CRANIOCEREBRAL TRAUMA (e.g., SKULL FRACTURE involving the TEMPORAL BONE;), NEUROSURGICAL PROCEDURES; or other conditions, but may rarely occur spontaneously. (From Am J Otol 1995 Nov;16(6):765-71)	""	0	#FFFFFF
D002559	C10.597.114.750|C10.900.300.109.750|C23.888.592.114.624|C23.888.852.834.500|C26.915.300.225.750	Cerebrospinal Fluid Rhinorrhea	Discharge of cerebrospinal fluid through the nose. Common etiologies include trauma, neoplasms, and prior surgery, although the condition may occur spontaneously. (Otolaryngol Head Neck Surg 1997 Apr;116(4):442-9)	""	0	#FFFFFF
D002561	C10.228.140.300|C14.907.253	Cerebrovascular Disorders	A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.	""	0	#FFFFFF
D002573	C10.668.829.550.850.200|C14.907.863.200|C16.131.621.174	Cervical Rib Syndrome	A condition associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the thoracic outlet and caused by a complete or incomplete anomalous CERVICAL RIB or fascial band connecting the tip of a cervical rib with the first thoracic rib. Clinical manifestations may include pain in the neck and shoulder which radiates into the upper extremity, PARESIS or PARALYSIS of brachial plexus innervated muscles; sensory loss; PARESTHESIAS; ISCHEMIA; and EDEMA. (Adams et al., Principles of Neurology, 6th ed, p214)	""	0	#FFFFFF
D002575	C12.050.351.500.852.593.150|C12.100.250.852.593.150	Uterine Cervicitis	Inflammation of the UTERINE CERVIX.	""	0	#FFFFFF
D002577	C12.050.351.500.852.593|C12.100.250.852.593	Uterine Cervical Diseases	Pathological processes of the UTERINE CERVIX.	""	0	#FFFFFF
D002578	C04.834.818|C12.050.351.500.852.593.074|C12.100.250.852.593.074	Uterine Cervical Dysplasia	Abnormal development of immature squamous EPITHELIAL CELLS of the UTERINE CERVIX, a term used to describe premalignant cytological changes in the cervical EPITHELIUM. These atypical cells do not penetrate the epithelial BASEMENT MEMBRANE.	""	0	#FFFFFF
D002579	C12.050.351.500.852.593.112|C12.100.250.852.593.112	Uterine Cervical Erosion	Loss or destruction of the epithelial lining of the UTERINE CERVIX.	""	0	#FFFFFF
D002581	C12.050.351.500.852.593.120|C12.050.703.039.089.339|C12.100.250.852.593.120	Uterine Cervical Incompetence	Incompetent UTERINE CERVIX is usually diagnosed in the second trimester of PREGNANCY. It is characterized by passive painless cervical dilation in the absence of UTERINE CONTRACTION; BLEEDING; INFECTION; and sometimes with the amniotic sac (AMNIOTIC MEMBRANE) bulging through the partially dilated cervix. Left untreated, this condition may lead to premature pregnancy loss, such as HABITUAL ABORTION.	""	0	#FFFFFF
D002583	C04.588.945.418.948.850|C12.050.351.500.852.593.131|C12.050.351.500.852.762.850|C12.050.351.937.418.875.850|C12.100.250.852.593.131|C12.100.250.852.762.850|C12.900.418.875.850	Uterine Cervical Neoplasms	Tumors or cancer of the UTERINE CERVIX.	""	0	#FFFFFF
D002590	C01.610.335.190	Cestode Infections	Infections with true tapeworms of the helminth subclass CESTODA.	""	0	#FFFFFF
D002598	C01.610.752.300.900.200.190|C01.920.625.190|C14.280.238.190	Chagas Cardiomyopathy	A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.	""	0	#FFFFFF
D002601	C01.150.252.400.794.840.500.500|C01.150.252.400.840.500.500	Chancre	The primary sore of syphilis, a painless indurated, eroded papule, occurring at the site of entry of the infection.	""	0	#FFFFFF
D002602	C01.150.252.400.700.433.308|C01.150.252.734.201|C01.221.812.281.201|C01.778.281.201|C12.100.937.281.201	Chancroid	Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.	""	0	#FFFFFF
D002607	C10.500.300.200|C10.574.500.495.200|C10.668.829.800.300.200|C16.131.666.300.200|C16.320.400.375.200	Charcot-Marie-Tooth Disease	A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)	""	0	#FFFFFF
D002609	C11.270.040.772|C15.378.553.774.257|C16.320.798.375|C20.673.774.257|C20.673.795.375	Chediak-Higashi Syndrome	A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.	""	0	#FFFFFF
D002613	C07.465.409.215	Cheilitis	Inflammation of the lips. It is of various etiologies and degrees of pathology.	""	0	#FFFFFF
D002636	C05.116.099.708.375.199|C05.500.174|C07.320.173|C16.131.621.207.540.170|C16.320.170	Cherubism	A fibro-osseous hereditary disease of the jaws. The swollen jaws and raised eyes give a cherubic appearance; multiple radiolucencies are evident upon radiographic examination.	""	0	#FFFFFF
D002637	C23.888.592.612.233	Chest Pain	Pressure, burning, or numbness in the chest.	""	0	#FFFFFF
D002639	C08.618.182|C23.888.852.227	Cheyne-Stokes Respiration	An abnormal pattern of breathing characterized by alternating periods of apnea and deep, rapid breathing. The cycle begins with slow, shallow breaths that gradually increase in depth and rate and is then followed by a period of apnea. The period of apnea can last 5 to 30 seconds, then the cycle repeats every 45 seconds to 3 minutes.	""	0	#FFFFFF
D002640	C12.050.703.844.506.389.500|C17.800.090.937.439.500	Chiari-Frommel Syndrome	A POSTPARTUM condition consists of persistent lactation (GALACTORRHEA) and AMENORRHEA in patients not BREAST FEEDING.	""	0	#FFFFFF
D002644	C01.925.256.466.930.250	Chickenpox	A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)	""	0	#FFFFFF
D002647	C26.212.500.217|C26.417.217	Chilblains	Recurrent localized itching, swelling and painful erythema on the fingers, toes or ears, produced by exposure to cold.	""	0	#FFFFFF
D002690	C01.150.252.400.210.125|C01.150.252.734.301|C01.221.812.281.301|C01.778.281.301|C12.100.937.281.301	Chlamydia Infections	Infections with bacteria of the genus CHLAMYDIA.	""	0	#FFFFFF
D002694	C01.150.252.400.210	Chlamydiaceae Infections	Infections with bacteria of the family CHLAMYDIACEAE.	""	0	#FFFFFF
D002754	C08.460.171|C08.695.271|C09.603.171|C16.131.740.271	Choanal Atresia	A congenital abnormality that is characterized by a blocked CHOANAE, the opening between the nose and the NASOPHARYNX. Blockage can be unilateral or bilateral; bony or membranous.	""	0	#FFFFFF
D002759	C04.557.470.035.085	Adenoma, Bile Duct	A benign tumor of the intrahepatic bile ducts.	""	0	#FFFFFF
D002761	C06.130.120.200	Cholangitis	Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.	""	0	#FFFFFF
D002764	C06.130.564.263	Cholecystitis	Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.	""	0	#FFFFFF
D002769	C06.130.409	Cholelithiasis	Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).	""	0	#FFFFFF
D002771	C01.150.252.400.959.347	Cholera	An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.	""	0	#FFFFFF
D002779	C06.130.120.135	Cholestasis	Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).	""	0	#FFFFFF
D002780	C06.130.120.135.250|C06.552.150	Cholestasis, Intrahepatic	Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).	""	0	#FFFFFF
D002781	C17.800.428.260	Cholesteatoma	A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.	""	0	#FFFFFF
D002796	C18.654.521.500.133.699.160	Choline Deficiency	A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)	""	0	#FFFFFF
D002804	C04.557.450.565.250	Chondroblastoma	A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. It occurs primarily in the epiphyses of adolescents. It is relatively rare and represents less than 2% of all primary bone tumors. The peak incidence is in the second decade of life; it is about twice as common in males as in females. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1846)	""	0	#FFFFFF
D002805	C05.550.114.264|C05.550.354.125	Chondrocalcinosis	Presence of CALCIUM PYROPHOSPHATE in the connective tissues such as the cartilaginous structures of  joints. When accompanied by GOUT-like symptoms, it is referred to as pseudogout.	""	0	#FFFFFF
D002806	C05.116.099.708.195	Chondrodysplasia Punctata	A heterogeneous group of bone dysplasias, the common character of which is stippling of the epiphyses in infancy. The group includes a severe autosomal recessive form (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC), an autosomal dominant form (Conradi-Hunermann syndrome), and a milder X-linked form. Metabolic defects associated with impaired peroxisomes are present only in the rhizomelic form.	""	0	#FFFFFF
D002812	C04.557.450.565.265	Chondroma	A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)	""	0	#FFFFFF
D002813	C04.557.450.565.280|C04.557.450.795.300	Chondrosarcoma	A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)	""	0	#FFFFFF
D002817	C04.557.465.220	Chordoma	A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)	""	0	#FFFFFF
D002819	C10.228.662.262.249|C10.597.350.250|C23.888.592.350.250	Chorea	Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES.	""	0	#FFFFFF
D002820	C04.557.465.955.416.812.500|C04.850.908.416.750.500|C12.050.703.720.949.416.875.500	Hydatidiform Mole, Invasive	A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.	""	0	#FFFFFF
D002821	C12.050.703.277.030|C12.050.703.420.339.260|C12.050.703.590.268|C16.300.030	Chorioamnionitis	INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY.	""	0	#FFFFFF
D002822	C04.557.465.955.207|C04.557.470.200.025.455|C04.850.908.208|C12.050.703.720.949.208	Choriocarcinoma	A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).	""	0	#FFFFFF
D002825	C11.768.773.348|C11.941.160.478.400|C11.941.879.780.900.300.318	Chorioretinitis	Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.	""	0	#FFFFFF
D002828	C23.300.250	Choristoma	A mass of histologically normal tissue present in an abnormal location.	""	0	#FFFFFF
D002830	C04.588.364.978.223|C11.319.494.198|C11.941.160.238|C11.941.855.198	Choroid Neoplasms	Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).	""	0	#FFFFFF
D002832	C11.290.195|C11.941.160.177|C23.550.414.756.300	Choroid Hemorrhage	Hemorrhage from the vessels of the choroid.	""	0	#FFFFFF
D002833	C11.941.160.478|C11.941.879.780.900.300	Choroiditis	Inflammation of the choroid.	""	0	#FFFFFF
D002836	C15.378.100.100.510|C15.378.100.141.510|C15.378.463.510|C16.320.099.510|C16.320.322.235	Hemophilia B	A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)	""	0	#FFFFFF
D002862	C01.150.703.302.110|C01.800.200.110|C17.800.838.208.241	Chromoblastomycosis	Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. The extremity may become swollen and, at its distal portion, covered with various nodular, tumorous, verrucous lesions that resemble cauliflower. In rare instances, the disease may begin on the hand or wrist and involve the entire upper extremity. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p362)	""	0	#FFFFFF
D002869	C23.550.210	Chromosome Aberrations	Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.	""	0	#FFFFFF
D002872	C23.550.210.050.500.500	Chromosome Deletion	Actual loss of portion of a chromosome.	""	0	#FFFFFF
D002873	C23.550.210.110.180|C23.550.362.180.180	Chromosome Fragility	Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related aberrations.	""	0	#FFFFFF
D002908	C23.550.291.500	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	""	0	#FFFFFF
D002915	C06.844.200	Chylous Ascites	Presence of milky lymph (CHYLE) in the PERITONEAL CAVITY, with or without infection.	""	0	#FFFFFF
D002916	C08.528.142	Chylothorax	The presence of chyle in the thoracic cavity. (Dorland, 27th ed)	""	0	#FFFFFF
D002921	C23.550.355.274	Cicatrix	The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.	""	0	#FFFFFF
D002925	C08.200|C09.150|C16.131.077.245.500|C16.320.184.500	Ciliary Motility Disorders	Conditions caused by abnormal CILIA movement in the body, usually causing KARTAGENER SYNDROME, chronic respiratory disorders, chronic SINUSITIS, and chronic OTITIS. Abnormal ciliary beating is likely due to defects in any of the 200 plus ciliary proteins, such as missing motor enzyme DYNEIN arms.	""	0	#FFFFFF
D002971	C07.465.409.225|C07.465.525.164|C07.650.525.164|C16.131.850.525.164	Cleft Lip	Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.	""	0	#FFFFFF
D002972	C05.500.460.185|C05.660.207.540.460.185|C07.320.440.185|C07.465.525.185|C07.650.500.460.185|C07.650.525.185|C16.131.621.207.540.460.185|C16.131.850.500.460.185|C16.131.850.525.185	Cleft Palate	Congenital fissure of the soft and/or hard palate, due to faulty fusion.	""	0	#FFFFFF
D002973	C05.116.099.708.207|C05.660.207.207|C16.131.621.207.207	Cleidocranial Dysplasia	Autosomal dominant syndrome in which there is delayed closing of the CRANIAL FONTANELLES; complete or partial absence of the collarbones (CLAVICLES); wide PUBIC SYMPHYSIS; short middle phalanges of the fifth fingers; and dental and vertebral anomalies.	""	0	#FFFFFF
D003003	C01.610.335.865.148	Clonorchiasis	Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)	""	0	#FFFFFF
D003015	C01.150.252.410.222	Clostridium Infections	Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species.	""	0	#FFFFFF
D003025	C05.330.488.655.063|C05.330.495.681.063|C05.660.585.512.380.813.063|C16.131.621.585.512.500.681.063	Clubfoot	A deformed foot in which the foot is plantarflexed, inverted, and adducted.	""	0	#FFFFFF
D003027	C10.228.140.546.399.937.500	Cluster Headache	A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	""	0	#FFFFFF
D003043	C04.697.098.875|C23.550.727.098.750	Cocarcinogenesis	The combination of two or more different factors in the production of cancer.	""	0	#FFFFFF
D003047	C01.150.703.203	Coccidioidomycosis	Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN.	""	0	#FFFFFF
D003048	C01.610.752.250	Coccidiosis	Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA.	""	0	#FFFFFF
D003057	C05.116.099.343.250|C10.574.500.362|C16.131.077.250|C16.320.240.562|C16.320.400.200|C18.452.284.250	Cockayne Syndrome	A syndrome characterized by multiple system abnormalities including DWARFISM; PHOTOSENSITIVITY DISORDERS; PREMATURE AGING; and HEARING LOSS. It is caused by mutations of a number of autosomal recessive genes encoding proteins that involve transcriptional-coupled DNA REPAIR processes. Cockayne syndrome is classified by the severity and age of onset. Type I (classical; CSA) is early childhood onset in the second year of life; type II (congenital; CSB) is early onset at birth with severe symptoms; type III (xeroderma pigmentosum; XP) is late childhood onset with mild symptoms.	""	0	#FFFFFF
D003074	C08.381.884	Solitary Pulmonary Nodule	A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.	""	0	#FFFFFF
D003085	C16.614.166	Colic	A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.	""	0	#FFFFFF
D003092	C06.405.205.265|C06.405.469.158.188	Colitis	Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.	""	0	#FFFFFF
D003093	C06.405.205.265.231|C06.405.205.731.249|C06.405.469.158.188.231|C06.405.469.432.249	Colitis, Ulcerative	Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	""	0	#FFFFFF
D003095	C17.300.200	Collagen Diseases	"Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that ""collagen"" was equivalent to ""connective tissue"", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term ""collagen diseases"" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)"	""	0	#FFFFFF
D003100	C05.550.518.336.500|C26.289.336.500|C26.404.562.356	Colles' Fracture	Fracture of the lower end of the radius in which the lower fragment is displaced posteriorly.	""	0	#FFFFFF
D003103	C11.250.110|C11.270.147|C16.131.384.282	Coloboma	Congenital anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation.	""	0	#FFFFFF
D003108	C06.405.469.158	Colonic Diseases	Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).	""	0	#FFFFFF
D003109	C06.405.469.158.272	Colonic Diseases, Functional	Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.	""	0	#FFFFFF
D003110	C04.588.274.476.411.307.180|C06.301.371.411.307.180|C06.405.249.411.307.180|C06.405.469.158.356.180|C06.405.469.491.307.180	Colonic Neoplasms	Tumors or cancer of the COLON.	""	0	#FFFFFF
D003111	C23.300.825.411.235	Colonic Polyps	Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.	""	0	#FFFFFF
D003112	C06.405.469.158.272.217|C06.405.469.531.492.500.217	Colonic Pseudo-Obstruction	Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.	""	0	#FFFFFF
D003117	C10.597.751.941.256|C11.270.151.500|C11.966.256|C23.888.592.763.941.256	Color Vision Defects	Defects of color vision are mainly hereditary traits but can be secondary to acquired or developmental abnormalities in the CONES (RETINA). Severity of hereditary defects of color vision depends on the degree of mutation of the ROD OPSINS genes (on X CHROMOSOME and CHROMOSOME 3) that code the photopigments for red, green and blue.	""	0	#FFFFFF
D003121	C01.920.930.200|C01.925.081.234|C01.925.782.791.482	Colorado Tick Fever	A febrile illness characterized by chills, aches, vomiting, leukopenia, and sometimes encephalitis. It is caused by the COLORADO TICK FEVER VIRUS, a reovirus transmitted by the tick Dermacentor andersoni.	""	0	#FFFFFF
D003123	C04.588.274.476.411.307.190|C04.700.250|C06.301.371.411.307.190|C06.405.249.411.307.190|C06.405.469.158.356.190|C06.405.469.491.307.190|C16.320.700.250|C18.452.284.255	Colorectal Neoplasms, Hereditary Nonpolyposis	A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.	""	0	#FFFFFF
D003128	C10.597.606.358.800.200|C23.888.592.604.359.800.200	Coma	A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.	""	0	#FFFFFF
D003137	C06.130.120.250	Common Bile Duct Diseases	Diseases of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.	""	0	#FFFFFF
D003138	C04.588.274.120.250.250|C06.130.120.120.280|C06.130.120.250.280|C06.130.320.120.280|C06.301.120.250.250	Common Bile Duct Neoplasms	Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.	""	0	#FFFFFF
D003139	C01.748.162|C01.925.782.687.207|C08.730.162	Common Cold	A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.	""	0	#FFFFFF
D003141	C01.221|C23.550.291.531	Communicable Diseases	An illness caused by an infectious agent or its toxins that occurs through the direct or indirect transmission of the infectious agent or its products from an infected individual or via an animal, vector or the inanimate environment to a susceptible animal or human host.	""	0	#FFFFFF
D003147	C10.597.606.150|C23.888.592.604.150	Communication Disorders	Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.	""	0	#FFFFFF
D003161	C05.651.180|C14.907.303	Compartment Syndromes	Conditions in which increased pressure within a limited space compromises the BLOOD CIRCULATION and function of tissue within that space. Some of the causes of increased pressure are TRAUMA, tight dressings, HEMORRHAGE, and exercise. Sequelae include nerve compression (NERVE COMPRESSION SYNDROMES); PARALYSIS; and ISCHEMIC CONTRACTURE. FASCIOTOMY is often used to decompress increased pressure and eliminate pain associated with compartment syndromes.	""	0	#FFFFFF
D003218	C01.221.812.640.220|C01.778.640.220|C01.925.256.650.810.217|C01.925.813.220|C01.925.825.810.110|C01.925.928.914.217|C12.100.937.640.220|C17.800.838.790.810.110	Condylomata Acuminata	Sexually transmitted form of anogenital warty growth caused by the human papillomaviruses.	""	0	#FFFFFF
D003221	C10.597.606.337|C23.888.592.604.339	Confusion	A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.	""	0	#FFFFFF
D003229	C11.187	Conjunctival Diseases	Diseases involving the CONJUNCTIVA.	""	0	#FFFFFF
D003230	C04.588.364.235|C11.187.169|C11.319.217	Conjunctival Neoplasms	Tumors or cancer of the CONJUNCTIVA.	""	0	#FFFFFF
D003231	C11.187.183	Conjunctivitis	INFLAMMATION of the CONJUNCTIVA.	""	0	#FFFFFF
D003232	C01.375.725.250.250|C01.925.325.250.250|C01.925.782.687.359.201|C11.187.183.240.216|C11.294.800.250.250	Conjunctivitis, Acute Hemorrhagic	A highly contagious disease characterized by subconjunctival hemorrhage, sudden swelling of the eyelids and congestion, redness, and pain in the eye. Epidemic conjunctivitis caused by Enterovirus 70 (EV-70) was first described in Africa in 1969. It is caused also by Coxsackievirus A24 variant (CA24v). Epidemics by this organism have appeared most frequently in Asia.	""	0	#FFFFFF
D003233	C11.187.183.200|C20.543.480.200	Conjunctivitis, Allergic	Conjunctivitis due to hypersensitivity to various allergens.	""	0	#FFFFFF
D003234	C01.150.252.289.225|C01.375.354.220|C11.187.183.220|C11.294.354.220	Conjunctivitis, Bacterial	Purulent infections of the conjunctiva by several species of gram-negative, gram-positive, or acid-fast organisms. Some of the more commonly found genera causing conjunctival infections are Haemophilus, Streptococcus, Neisseria, and Chlamydia.	""	0	#FFFFFF
D003235	C01.150.252.289.225.250|C01.150.252.400.210.125.245|C01.375.354.220.250|C11.187.183.220.250|C11.294.354.220.250	Conjunctivitis, Inclusion	An infection of the eyes characterized by the presence in conjunctival epithelial cells of inclusion bodies indistinguishable from those of trachoma. It is acquired by infants during birth and by adults from swimming pools. The etiological agent is CHLAMYDIA TRACHOMATIS whose natural habitat appears to be the genito-urinary tract. Inclusion conjunctivitis is a less severe disease than trachoma and usually clears up spontaneously.	""	0	#FFFFFF
D003236	C01.375.725.250|C01.925.325.250|C11.187.183.240|C11.294.800.250	Conjunctivitis, Viral	Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.	""	0	#FFFFFF
D003240	C17.300	Connective Tissue Diseases	A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.	""	0	#FFFFFF
D003244	C10.597.606.358|C23.888.592.604.359	Consciousness Disorders	Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.	""	0	#FFFFFF
D003248	C23.888.821.150	Constipation	Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.	""	0	#FFFFFF
D003251	C23.300.287	Constriction, Pathologic	The condition of an anatomical structure's being constricted beyond normal dimensions.	""	0	#FFFFFF
D003286	C05.550.323|C05.651.197	Contracture	Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.	""	0	#FFFFFF
D003288	C26.974.250	Contusions	Injuries resulting in hemorrhage, usually manifested in the skin.	""	0	#FFFFFF
D003289	C23.550.291.562	Convalescence	The period of recovery following an illness.	""	0	#FFFFFF
D003294	C10.597.742.571|C23.888.592.742.571	Seizures, Febrile	Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)	""	0	#FFFFFF
D003310	C14.240.400.200|C14.280.400.200|C16.131.240.400.200	Cor Triatriatum	A malformation of the heart in which the embryonic common PULMONARY VEIN was not incorporated into the LEFT ATRIUM leaving behind a perforated fibromuscular membrane bisecting the left atrium, a three-atrium heart. The opening between the two left atrium sections determines the degree of obstruction to pulmonary venous return, pulmonary venous and pulmonary arterial hypertension.	""	0	#FFFFFF
D003316	C11.204	Corneal Diseases	Diseases of the cornea.	""	0	#FFFFFF
D003317	C11.204.236|C11.270.162|C16.320.290.162	Corneal Dystrophies, Hereditary	Bilateral hereditary disorders of the cornea, usually autosomal dominant, which may be present at birth but more frequently develop during adolescence and progress slowly throughout life. Central macular dystrophy is transmitted as an autosomal recessive defect.	""	0	#FFFFFF
D003318	C11.204.299	Corneal Opacity	Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.	""	0	#FFFFFF
D003320	C01.375.177|C11.204.564.225|C11.294.177	Corneal Ulcer	Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.	""	0	#FFFFFF
D003323	C14.280.647.250.250|C14.907.055.395|C14.907.585.250.250	Coronary Aneurysm	Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.	""	0	#FFFFFF
D003324	C14.280.647.250.260|C14.907.137.126.339|C14.907.585.250.260	Coronary Artery Disease	Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.	""	0	#FFFFFF
D003327	C14.280.647.250|C14.907.585.250	Coronary Disease	An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.	""	0	#FFFFFF
D003328	C14.280.647.250.290|C14.907.355.830.220|C14.907.585.250.290	Coronary Thrombosis	Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.	""	0	#FFFFFF
D003329	C14.280.647.250.295|C14.907.585.250.295	Coronary Vasospasm	Spasm of the large- or medium-sized coronary arteries.	""	0	#FFFFFF
D003330	C14.240.400.210|C14.280.400.210|C16.131.240.400.210	Coronary Vessel Anomalies	Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.	""	0	#FFFFFF
D003333	C01.925.782.600.550	Coronaviridae Infections	Virus diseases caused by CORONAVIRIDAE.	""	0	#FFFFFF
D003354	C01.150.252.410.040.246	Corynebacterium Infections	Infections with bacteria of the genus CORYNEBACTERIUM.	""	0	#FFFFFF
D003371	C08.618.248|C23.888.852.293	Cough	A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.	""	0	#FFFFFF
D003384	C01.925.782.687.359.213	Coxsackievirus Infections	A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.	""	0	#FFFFFF
D003387	C07.793.850.750.300|C26.900.750.300	Cracked Tooth Syndrome	Incomplete fracture of any part of a tooth, characterized by pain during mastication and sensitivity to heat, cold, sweet or sour tastes, and alcohol; it is often undiagnosed because the tooth is usually X-ray negative and normal to pulp vitality tests.	""	0	#FFFFFF
D003389	C10.292	Cranial Nerve Diseases	Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.	""	0	#FFFFFF
D003390	C04.588.614.300|C04.588.614.596.240|C10.292.225|C10.551.360|C10.551.775.250	Cranial Nerve Neoplasms	Benign and malignant neoplasms that arise from one or more of the twelve cranial nerves.	""	0	#FFFFFF
D003394	C05.116.099.370.231|C05.660.207.231|C16.131.621.207.231	Craniofacial Dysostosis	Autosomal dominant CRANIOSYNOSTOSIS with shallow ORBITS; EXOPHTHALMOS; and maxillary hypoplasia.	""	0	#FFFFFF
D003397	C04.557.465.625.200|C04.557.580.625.200	Craniopharyngioma	A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)	""	0	#FFFFFF
D003398	C05.116.099.370.894.232|C05.660.207.240|C05.660.906.364|C16.131.621.207.240|C16.131.621.906.364	Craniosynostoses	Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.	""	0	#FFFFFF
D003409	C05.116.099.343.347|C05.116.132.256|C16.320.240.625|C19.297.155|C19.874.482.281	Congenital Hypothyroidism	A condition in infancy or early childhood due to an in-utero deficiency of THYROID HORMONES that can be caused by genetic or environmental factors, such as thyroid dysgenesis or HYPOTHYROIDISM in infants of mothers treated with THIOURACIL during pregnancy. Endemic cretinism is the result of iodine deficiency. Clinical symptoms include severe MENTAL RETARDATION, impaired skeletal development, short stature, and MYXEDEMA.	""	0	#FFFFFF
D003410	C10.597.606.360.180|C16.131.077.262|C16.131.260.190|C16.320.180.190	Cri-du-Chat Syndrome	An infantile syndrome characterized by a cat-like cry, failure to thrive, microcephaly, MENTAL RETARDATION, spastic quadriparesis, micro- and retrognathia, glossoptosis, bilateral epicanthus, hypertelorism, and tiny external genitalia. It is caused by a deletion of the short arm of chromosome 5 (5p-).	""	0	#FFFFFF
D003414	C16.320.565.300.281|C18.452.648.300.281	Crigler-Najjar Syndrome	A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.	""	0	#FFFFFF
D003420	C14.240.400.220|C14.280.400.220|C16.131.240.400.220	Crisscross Heart	A developmental malformation of the heart characterized by a twisted but not defective atrioventicular connection. The abnormal rotation of the ventricular mass around its long axis results in the crossing of the inflow streams of the two ventricles. Other features include hypoplasia of the TRICUSPID VALVE and RIGHT VENTRICLE.	""	0	#FFFFFF
D003424	C06.405.205.731.500|C06.405.469.432.500	Crohn Disease	A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.	""	0	#FFFFFF
D003428	C01.248|C23.550.291.875.500	Cross Infection	Any infection which a patient contracts in a health-care institution.	""	0	#FFFFFF
D003440	C08.360.535.365|C09.400.535.365	Croup	Inflammation involving the GLOTTIS or VOCAL CORDS and the subglottic larynx. Croup is characterized by a barking cough, HOARSENESS, and persistent inspiratory STRIDOR (a high-pitched breathing sound). It occurs chiefly in infants and children.	""	0	#FFFFFF
D003444	C26.257.500|C26.797.240	Crush Syndrome	Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.	""	0	#FFFFFF
D003449	C14.907.454.140|C15.378.147.780.243|C15.378.463.515.140|C20.683.780.250	Cryoglobulinemia	A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.	""	0	#FFFFFF
D003453	C01.150.703.248	Cryptococcosis	Fungal infection caused by genus CRYPTOCOCCUS.	""	0	#FFFFFF
D003456	C12.100.500.829.258|C12.200.294.829.258|C12.200.706.258|C12.800.258|C16.131.939.258|C19.391.829.258	Cryptorchidism	A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.	""	0	#FFFFFF
D003457	C01.610.432.269|C01.610.701.688.235|C01.610.752.250.269|C01.610.752.625.235|C06.405.469.452.269|C22.674.710.235	Cryptosporidiosis	Intestinal infection with organisms of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.	""	0	#FFFFFF
D003480	C19.053.800.367	Cushing Syndrome	A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.	""	0	#FFFFFF
D003483	C16.320.850.180|C17.300.230|C17.800.827.180	Cutis Laxa	A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)	""	0	#FFFFFF
D003490	C23.888.248	Cyanosis	A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule.	""	0	#FFFFFF
D003528	C04.557.470.200.025.220	Carcinoma, Adenoid Cystic	Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)	""	0	#FFFFFF
D003536	C04.557.470.200.025.480|C04.557.470.590.480	Cystadenocarcinoma	A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)	""	0	#FFFFFF
D003537	C04.557.470.035.320|C04.557.470.590.485	Cystadenoma	A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)	""	0	#FFFFFF
D003550	C06.689.202|C08.381.187|C16.320.190|C16.614.213	Cystic Fibrosis	An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.	""	0	#FFFFFF
D003551	C01.610.335.190.902.185	Cysticercosis	Infection with CYSTICERCUS, the larval form of the various tapeworms of the genus Taenia (usually T. solium in man). In humans they penetrate the intestinal wall and invade subcutaneous tissue, brain, eye, muscle, heart, liver, lung, and peritoneum. Brain involvement results in NEUROCYSTICERCOSIS.	""	0	#FFFFFF
D003554	C16.320.565.595.377|C18.452.648.595.377	Cystinosis	A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.	""	0	#FFFFFF
D003555	C12.050.351.968.419.815.885.250|C12.200.777.419.815.885.250|C12.950.419.815.885.250|C16.320.831.885.250	Cystinuria	An inherited disorder due to defective reabsorption of CYSTINE and other BASIC AMINO ACIDS by the PROXIMAL RENAL TUBULES. This form of aminoaciduria is characterized by the abnormally high urinary levels of cystine; LYSINE; ARGININE; and ORNITHINE. Mutations involve the amino acid transport protein gene SLC3A1.	""	0	#FFFFFF
D003556	C12.050.351.968.829.495|C12.200.777.829.495|C12.950.829.495	Cystitis	Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.	""	0	#FFFFFF
D003557	C04.557.450.795.650	Phyllodes Tumor	A type of connective tissue neoplasm typically arising from intralobular stroma of the breast. It is characterized by the rapid enlargement of an asymmetric firm mobile mass. Histologically, its leaf-like stromal clefts are lined by EPITHELIAL CELLS. Rare phyllodes tumor of the prostate is also known.	""	0	#FFFFFF
D003560	C04.182|C23.300.306	Cysts	Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.	""	0	#FFFFFF
D003586	C01.925.256.466.245	Cytomegalovirus Infections	Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.	""	0	#FFFFFF
D003607	C11.496.221	Dacryocystitis	Inflammation of the lacrimal sac. (Dorland, 27th ed)	""	0	#FFFFFF
D003616	C10.228.140.252.300|C10.228.140.602.500|C10.500.205|C16.131.666.205	Dandy-Walker Syndrome	A congenital abnormality of the central nervous system marked by failure of the midline structures of the cerebellum to develop, dilation of the fourth ventricle, and upward displacement of the transverse sinuses, tentorium, and torcula. Clinical features include occipital bossing, progressive head enlargement, bulging of anterior fontanelle, papilledema, ataxia, gait disturbances, nystagmus, and intellectual compromise. (From Menkes, Textbook of Child Neurology, 5th ed, pp294-5)	""	0	#FFFFFF
D003635	C10.597.606.360.210|C16.131.077.272|C16.131.260.210|C16.320.180.210	De Lange Syndrome	A syndrome characterized by growth retardation, severe MENTAL RETARDATION, short stature, a low-pitched growling cry, brachycephaly, low-set ears, webbed neck, carp mouth, depressed nasal bridge, bushy eyebrows meeting at the midline, hirsutism, and malformations of the hands. The condition may occur sporadically or be associated with an autosomal dominant pattern of inheritance or duplication of the long arm of chromosome 3. (Menkes, Textbook of Child Neurology, 5th ed, p231)	""	0	#FFFFFF
D003638	C09.218.458.341.186|C10.597.751.418.341.186|C23.888.592.763.393.341.186	Deafness	A general term for the complete loss of the ability to hear from both ears.	""	0	#FFFFFF
D003639	C09.218.458.341.900|C10.597.751.418.341.900|C23.888.592.763.393.341.900	Hearing Loss, Sudden	Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.	""	0	#FFFFFF
D003643	C23.550.260	Death	Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.	""	0	#FFFFFF
D003645	C23.550.260.322	Death, Sudden	The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.	""	0	#FFFFFF
D003649	C05.116.198.247.400|C18.452.104.247.400|C18.452.174.289	Decalcification, Pathologic	The loss of calcium salts from bones and teeth. Bacteria may be responsible for this occurrence in teeth. Old age may be a factor contributing to calcium loss, as is the presence of diseases such as rheumatoid arthritis.	""	0	#FFFFFF
D003655	C10.597.305|C23.888.592.298	Decerebrate State	A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)	""	0	#FFFFFF
D003665	C26.120.248	Decompression Sickness	A condition occurring as a result of exposure to a rapid fall in ambient pressure. Gases, nitrogen in particular, come out of solution and form bubbles in body fluid and blood. These gas bubbles accumulate in joint spaces and the peripheral circulation impairing tissue oxygenation causing disorientation, severe pain, and potentially death.	""	0	#FFFFFF
D003668	C17.800.893.665	Pressure Ulcer	An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.	""	0	#FFFFFF
D003677	C18.654.521.500	Deficiency Diseases	A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)	""	0	#FFFFFF
D003680	C06.405.117.119|C09.775.174	Deglutition Disorders	Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.	""	0	#FFFFFF
D003681	C18.452.950.179|C23.550.274	Dehydration	The condition that results from excessive loss of water from a living organism.	""	0	#FFFFFF
D003693	C10.597.606.337.500|C23.888.592.604.339.500	Delirium	A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)	""	0	#FFFFFF
D003699	C01.925.440.450|C01.925.782.450|C06.552.380.705.450	Hepatitis D	INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS, a defective RNA virus that can only infect HEPATITIS B patients. For its viral coating, hepatitis delta virus requires the HEPATITIS B SURFACE ANTIGENS produced by these patients. Hepatitis D can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis B, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	""	0	#FFFFFF
D003704	C10.228.140.380	Dementia	An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.	""	0	#FFFFFF
D003711	C10.314	Demyelinating Diseases	Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.	""	0	#FFFFFF
D003715	C01.920.500.270|C01.925.081.270|C01.925.782.350.250.214|C01.925.782.417.214	Dengue	An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.	""	0	#FFFFFF
D003719	C07.650.800.250|C07.793.700.250|C16.131.850.800.250	Dens in Dente	Anomaly of the tooth, found chiefly in upper lateral incisors. It is characterized by invagination of the enamel at the incisal edge.	""	0	#FFFFFF
D003728	C07.793.208.250|C23.300.175.350	Dental Calculus	Abnormal concretion or calcified deposit that forms around the teeth or dental prostheses.	""	0	#FFFFFF
D003731	C07.793.720.210	Dental Caries	Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	""	0	#FFFFFF
D003741	C07.793.208	Dental Deposits	Accumulations of microflora that lead to pathological plaque and calculus which cause PERIODONTAL DISEASES. It can be considered a type of BIOFILMS. It is subtly distinguished from the protective DENTAL PELLICLE.	""	0	#FFFFFF
D003744	C07.650.800.255|C07.793.700.255|C16.131.850.800.255	Dental Enamel Hypoplasia	An acquired or hereditary condition due to deficiency in the formation of tooth enamel (AMELOGENESIS). It is usually characterized by defective, thin, or malformed DENTAL ENAMEL. Risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors.	""	0	#FFFFFF
D003750	C07.793.720.210.220	Dental Fissures	Deep grooves or clefts in the surface of teeth equivalent to class 1 cavities in Black's classification of dental caries.	""	0	#FFFFFF
D003751	C07.465.614.187|C23.300.575.500.275	Dental Fistula	An abnormal passage in the oral cavity on the gingiva.	""	0	#FFFFFF
D003763	C07.793.221	Dental Leakage	The seepage of fluids, debris, and micro-organisms between the walls of a prepared dental cavity and the restoration.	""	0	#FFFFFF
D003769	C07.793.494.293	Dental Occlusion, Traumatic	An occlusion resulting in overstrain and injury to teeth, periodontal tissue, or other oral structures.	""	0	#FFFFFF
D003773	C07.793.208.377	Dental Plaque	A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.	""	0	#FFFFFF
D003784	C07.793.237.252	Dental Pulp Calcification	CALCINOSIS of the DENTAL PULP or ROOT CANAL.	""	0	#FFFFFF
D003788	C07.793.237	Dental Pulp Diseases	Endodontic diseases of the DENTAL PULP inside the tooth, which is distinguished from PERIAPICAL DISEASES of the tissue surrounding the root.	""	0	#FFFFFF
D003789	C07.793.237.283	Dental Pulp Exposure	The result of pathological changes in the hard tissue of a tooth caused by carious lesions, mechanical factors, or trauma, which render the pulp susceptible to bacterial invasion from the external environment.	""	0	#FFFFFF
D003790	C07.793.237.315|C23.550.717.182	Dental Pulp Necrosis	Death of pulp tissue with or without bacterial invasion. When the necrosis is due to ischemia with superimposed bacterial infection, it is referred to as pulp gangrene. When the necrosis is non-bacterial in origin, it is called pulp mummification.	""	0	#FFFFFF
D003803	C04.182.089.530.690.310|C05.500.470.690.310|C07.320.450.670.275	Dentigerous Cyst	Most common follicular odontogenic cyst. Occurs in relation to a partially erupted or unerupted tooth with at least the crown of the tooth to which the cyst is attached protruding into the cystic cavity. May give rise to an ameloblastoma and, in rare instances, undergo malignant transformation.	""	0	#FFFFFF
D003805	C07.650.800.260|C07.793.700.260|C16.131.850.800.260	Dentin Dysplasia	An apparently hereditary disorder of dentin formation, marked by a normal appearance of coronal dentin associated with pulpal obliteration, faulty root formation, and a tendency for peripheral lesions without obvious cause. (From Dorland, 27th ed)	""	0	#FFFFFF
D003807	C07.793.266	Dentin Sensitivity	Pain associated with exposed DENTIN surfaces of the teeth.	""	0	#FFFFFF
D003809	C07.793.237.378	Dentin, Secondary	Dentin formed by normal pulp after completion of root end formation.	""	0	#FFFFFF
D003811	C07.650.800.270|C07.793.700.270|C16.131.850.800.270	Dentinogenesis Imperfecta	An autosomal dominant disorder of tooth development characterized by opalescent dentin resulting in discoloration of the teeth. The dentin develops poorly with low mineral content while the pulp canal is obliterated.	""	0	#FFFFFF
D003872	C17.800.174	Dermatitis	Any inflammation of the skin.	""	0	#FFFFFF
D003873	C17.800.174.318|C17.800.815.318	Dermatitis, Exfoliative	The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)	""	0	#FFFFFF
D003874	C17.800.174.360|C17.800.865.360|C20.111.318	Dermatitis Herpetiformis	Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.	""	0	#FFFFFF
D003875	C17.800.174.600|C20.543.206.380|C25.100.468.380	Drug Eruptions	Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.	""	0	#FFFFFF
D003876	C16.320.850.210|C17.800.174.193|C17.800.815.193|C17.800.827.210|C20.543.480.343	Dermatitis, Atopic	A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	""	0	#FFFFFF
D003877	C17.800.174.255|C17.800.815.255	Dermatitis, Contact	A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	""	0	#FFFFFF
D003881	C01.150.703.302|C01.800.200|C17.800.838.208	Dermatomycoses	Superficial infections of the skin or its appendages by any of various fungi.	""	0	#FFFFFF
D003882	C05.651.594.819.500|C10.668.491.562.575.500|C17.300.250|C17.800.185	Dermatomyositis	A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)	""	0	#FFFFFF
D003884	C04.182.201|C04.557.465.910.250	Dermoid Cyst	A tumor consisting of displaced ectodermal structures along the lines of embryonic fusion, the wall being formed of epithelium-lined connective tissue, including skin appendages, and containing keratin, sebum, and hair. (Stedman, 25th ed)	""	0	#FFFFFF
D003914	C14.240.400.280|C14.280.400.280|C16.131.240.400.280|C16.131.810.250	Dextrocardia	A congenital defect in which the heart is located on the right side of the THORAX instead of on the left side (levocardia, the normal position). When dextrocardia is accompanied with inverted HEART ATRIA, a right-sided STOMACH, and a left-sided LIVER, the combination is called dextrocardia with SITUS INVERSUS. Dextrocardia may adversely affect other thoracic organs.	""	0	#FFFFFF
D003919	C12.050.351.968.419.135|C12.200.777.419.135|C12.950.419.135|C19.700.159	Diabetes Insipidus	A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.	""	0	#FFFFFF
D003920	C18.452.394.750|C19.246	Diabetes Mellitus	A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	""	0	#FFFFFF
D003921	C18.452.394.750.074|C19.246.240	Diabetes Mellitus, Experimental	Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.	""	0	#FFFFFF
D003922	C18.452.394.750.124|C19.246.267|C20.111.327	Diabetes Mellitus, Type 1	A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.	""	0	#FFFFFF
D003923	C18.452.394.750.149.500|C19.246.300.500	Diabetes Mellitus, Lipoatrophic	A type of diabetes mellitus that is characterized by severe INSULIN RESISTANCE and LIPODYSTROPHY. The latter may be generalized, partial, acquired, or congenital (LIPODYSTROPHY, CONGENITAL GENERALIZED).	""	0	#FFFFFF
D003924	C18.452.394.750.149|C19.246.300	Diabetes Mellitus, Type 2	A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	""	0	#FFFFFF
D003925	C14.907.320|C19.246.099.500	Diabetic Angiopathies	VASCULAR DISEASES that are associated with DIABETES MELLITUS.	""	0	#FFFFFF
D003926	C19.246.099.750	Diabetic Coma	A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy.	""	0	#FFFFFF
D003928	C12.050.351.968.419.192|C12.200.777.419.192|C12.950.419.192|C19.246.099.875	Diabetic Nephropathies	KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.	""	0	#FFFFFF
D003929	C10.668.829.300|C19.246.099.937	Diabetic Neuropathies	Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)	""	0	#FFFFFF
D003930	C11.768.257|C14.907.320.382|C19.246.099.500.382	Diabetic Retinopathy	Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.	""	0	#FFFFFF
D003963	C17.800.174.255.400.250|C17.800.815.255.400.250	Diaper Rash	A type of irritant dermatitis localized to the area in contact with a diaper and occurring most often as a reaction to prolonged contact with urine, feces, or retained soap or detergent.	""	0	#FFFFFF
D003965	C06.198.257|C16.131.314.244	Diaphragmatic Eventration	A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.	""	0	#FFFFFF
D003966	C05.116.099.708.180|C16.320.144	Camurati-Engelmann Syndrome	An autosomal dominant form of dysplasia that is characterized by progressive thickening of diaphyseal cortex of long bones. Mutations in the gene that encodes TRANSFORMING GROWTH FACTOR BETA1 are one cause of this disorder.	""	0	#FFFFFF
D003967	C23.888.821.214	Diarrhea	An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.	""	0	#FFFFFF
D003968	C23.888.821.214.500	Diarrhea, Infantile	DIARRHEA occurring in infants from newborn to 24-months old.	""	0	#FFFFFF
D003969	C04.557.465.625.650.240.847|C04.557.470.200.025.370.847|C04.588.274.761.500.750|C04.588.322.475.500.750|C06.301.761.500.750|C06.689.667.500.750|C19.344.421.500.750	Vipoma	A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide that causes VASODILATION; relaxation of smooth muscles; watery DIARRHEA; HYPOKALEMIA; and HYPOCHLORHYDRIA. Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. In most cases, Vipomas are located in the PANCREAS but can be found in extrapancreatic sites.	""	0	#FFFFFF
D003970	C07.650.800.320|C07.793.700.320|C16.131.850.800.320	Diastema	An abnormal opening or fissure between two adjacent teeth.	""	0	#FFFFFF
D004011	C01.610.335.865.224	Dicrocoeliasis	Infection with flukes of the genus Dicrocoelium.	""	0	#FFFFFF
D004022	C01.610.335.349.315|C01.610.335.508.700.775.825.315|C01.610.701.377.315|C22.674.377.315	Dictyocaulus Infections	Infection with nematodes of the genus DICTYOCAULUS. In deer, cattle, sheep, and horses the bronchi are the site of infestation.	""	0	#FFFFFF
D004030	C01.610.432.275|C01.610.752.275|C06.405.469.452.275	Dientamoebiasis	Gastrointestinal infection with organisms of the genus DIENTAMOEBA.	""	0	#FFFFFF
D004057	C05.116.540.410|C05.116.900.815.651	Hyperostosis, Diffuse Idiopathic Skeletal	A disease of elderly men characterized by large osteophytes that bridge vertebrae and ossification of ligaments and tendon insertions.	""	0	#FFFFFF
D004062	C05.660.207.103.500|C14.240.400.021.500|C14.280.400.044.500|C15.604.451.249.500|C16.131.077.019.500|C16.131.240.400.021.500|C16.131.260.019.500|C16.131.482.249.500|C16.131.621.207.103.500|C16.320.180.019.500|C19.642.482.500.500	DiGeorge Syndrome	Congenital syndrome characterized by a wide spectrum of characteristics including the absence of the THYMUS and PARATHYROID GLANDS resulting in T-cell immunodeficiency, HYPOCALCEMIA, defects in the outflow tract of the heart, and craniofacial anomalies.	""	0	#FFFFFF
D004065	C06.198|C16.131.314	Digestive System Abnormalities	Congenital structural abnormalities of the DIGESTIVE SYSTEM.	""	0	#FFFFFF
D004066	C06	Digestive System Diseases	Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).	""	0	#FFFFFF
D004067	C04.588.274|C06.301	Digestive System Neoplasms	Tumors or cancer of the DIGESTIVE SYSTEM.	""	0	#FFFFFF
D004108	C23.300.325	Dilatation, Pathologic	The condition of an anatomical structure's being dilated beyond normal dimensions.	""	0	#FFFFFF
D004154	C01.610.335.508.700.750.361.275	Dipetalonema Infections	Infections with nematodes of the genus DIPETALONEMA.	""	0	#FFFFFF
D004165	C01.150.252.410.040.246.388	Diphtheria	A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.	""	0	#FFFFFF
D004169	C01.610.335.190.304	Diphyllobothriasis	Infection with tapeworms of the genus Diphyllobothrium.	""	0	#FFFFFF
D004172	C10.597.751.941.339|C11.966.339|C23.888.592.763.941.339	Diplopia	A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one. Disorders associated with this condition include REFRACTIVE ERRORS; STRABISMUS; OCULOMOTOR NERVE DISEASES; TROCHLEAR NERVE DISEASES; ABDUCENS NERVE DISEASES; and diseases of the BRAIN STEM and OCCIPITAL LOBE.	""	0	#FFFFFF
D004184	C01.610.335.349.320|C01.610.335.508.700.750.361.290|C01.610.701.377.320|C22.674.377.320	Dirofilariasis	Infection with nematodes of the genus DIROFILARIA, usually in animals, especially dogs, but occasionally in man.	""	0	#FFFFFF
D004194	C23.550.288	Disease	A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.	""	0	#FFFFFF
D004195	C22.232	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	""	0	#FFFFFF
D004198	C23.550.291.687	Disease Susceptibility	A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.	""	0	#FFFFFF
D004200	C23.550.291.750	Diseases in Twins	Disorders affecting TWINS, one or both, at any age.	""	0	#FFFFFF
D004204	C05.550.518|C26.289	Joint Dislocations	Displacement of bones from their normal positions at a joint.	""	0	#FFFFFF
D004211	C15.378.100.220|C15.378.463.250|C15.378.925.220	Disseminated Intravascular Coagulation	A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.	""	0	#FFFFFF
D004216	C01.925.782.580.600.500.285|C22.268.265	Distemper	A name for several highly contagious viral diseases of animals, especially canine distemper. In dogs, it is caused by the canine distemper virus (DISTEMPER VIRUS, CANINE). It is characterized by a diphasic fever, leukopenia, gastrointestinal and respiratory inflammation and sometimes, neurologic complications. In cats it is known as FELINE PANLEUKOPENIA.	""	0	#FFFFFF
D004238	C06.405.205.282.500	Diverticulitis	Inflammation of a DIVERTICULUM or diverticula.	""	0	#FFFFFF
D004239	C06.405.205.282.500.250|C06.405.469.158.587.500	Diverticulitis, Colonic	Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.	""	0	#FFFFFF
D004240	C06.405.205.282.750|C23.300.415	Diverticulum	A pouch or sac developed from a tubular or saccular organ, such as the GASTROINTESTINAL TRACT.	""	0	#FFFFFF
D004241	C06.405.205.282.750.500|C23.300.415.500	Diverticulum, Colon	A pouch or sac opening from the COLON.	""	0	#FFFFFF
D004244	C23.888.592.763.237	Dizziness	An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.	""	0	#FFFFFF
D004266	C01.925.256	DNA Virus Infections	Diseases caused by DNA VIRUSES.	""	0	#FFFFFF
D004283	C22.268	Dog Diseases	Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.	""	0	#FFFFFF
D004310	C14.240.400.560.540.500|C14.240.400.915.300|C14.280.400.560.540.500|C14.280.400.915.300|C16.131.240.400.560.540.500|C16.131.240.400.915.300	Double Outlet Right Ventricle	Incomplete transposition of the great vessels in which both the AORTA and the PULMONARY ARTERY arise from the RIGHT VENTRICLE. The only outlet of the LEFT VENTRICLE is a large ventricular septal defect (VENTRICULAR SEPTAL DEFECTS or VSD). The various subtypes are classified by the location of the septal defect, such as subaortic, subpulmonary, or noncommitted.	""	0	#FFFFFF
D004313	C01.610.701.688.367|C01.610.752.300.900.226|C01.610.752.625.367|C22.674.710.367	Dourine	A disease of horses and donkeys caused by Trypanosoma equiperdum. The disease occurs in Africa, the Americas, and Asia.	""	0	#FFFFFF
D004314	C10.597.606.360.220|C16.131.077.327|C16.131.260.260|C16.320.180.260	Down Syndrome	A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)	""	0	#FFFFFF
D004320	C01.610.335.508.700.750.299	Dracunculiasis	Infection with nematodes of the genus Dracunculus. One or more worms may be seen at a time, with the legs and feet being the most commonly infected areas. Symptoms include pruritus, nausea, vomiting, diarrhea, or asthmatic attacks.	""	0	#FFFFFF
D004332	C23.550.260.393|C26.304	Drowning	Death that occurs as a result of anoxia or heart arrest, associated with immersion in liquid.	""	0	#FFFFFF
D004342	C20.543.206|C25.100.468	Drug Hypersensitivity	Immunologically mediated adverse reactions to medicinal substances used legally or illegally.	""	0	#FFFFFF
D004368	C07.465.227	Dry Socket	A condition sometimes occurring after tooth extraction, particularly after traumatic extraction, resulting in a dry appearance of the exposed bone in the socket, due to disintegration or loss of the blood clot. It is basically a focal osteomyelitis without suppuration and is accompanied by severe pain (alveolalgia) and foul odor. (Dorland, 28th ed)	""	0	#FFFFFF
D004370	C10.292.562.250|C11.270.235|C11.590.224|C16.320.290.235	Duane Retraction Syndrome	A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.	""	0	#FFFFFF
D004374	C14.240.400.340|C14.280.400.340|C16.131.240.400.340	Ductus Arteriosus, Patent	A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.	""	0	#FFFFFF
D004377	C06.405.748.630.310|C23.550.767.812.500	Dumping Syndrome	Gastrointestinal symptoms resulting from an absent or nonfunctioning pylorus.	""	0	#FFFFFF
D004378	C06.405.469.275	Duodenal Diseases	Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).	""	0	#FFFFFF
D004379	C04.588.274.476.411.445|C06.301.371.411.445|C06.405.249.411.445|C06.405.469.275.270|C06.405.469.491.445	Duodenal Neoplasms	Tumors or cancer of the DUODENUM.	""	0	#FFFFFF
D004380	C06.405.469.275.395|C06.405.469.531.311	Duodenal Obstruction	Hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents.	""	0	#FFFFFF
D004381	C06.405.469.275.800.348|C06.405.748.586.349	Duodenal Ulcer	A PEPTIC ULCER located in the DUODENUM.	""	0	#FFFFFF
D004382	C06.405.205.462.249|C06.405.469.275.600|C06.405.469.326.750	Duodenitis	Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.	""	0	#FFFFFF
D004383	C06.405.469.275.700|C06.405.748.240	Duodenogastric Reflux	Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.	""	0	#FFFFFF
D004387	C04.557.450.565.590.340.173|C05.651.197.270|C17.300.270	Dupuytren Contracture	A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.	""	0	#FFFFFF
D004392	C05.116.099.343|C16.320.240|C19.297	Dwarfism	A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.	""	0	#FFFFFF
D004393	C05.116.099.343.445|C05.116.132.358|C10.228.140.617.738.300.300|C19.297.312|C19.700.482.311	Dwarfism, Pituitary	A form of dwarfism caused by complete or partial GROWTH HORMONE deficiency, resulting from either the lack of GROWTH HORMONE-RELEASING FACTOR from the HYPOTHALAMUS or from the mutations in the growth hormone gene (GH1) in the PITUITARY GLAND. It is also known as Type I pituitary dwarfism. Human hypophysial dwarf is caused by a deficiency of HUMAN GROWTH HORMONE during development.	""	0	#FFFFFF
D004401	C10.597.606.150.500.800.150.200|C23.888.592.604.150.500.800.150.200	Dysarthria	Disorders of speech articulation caused by imperfect coordination of pharynx, larynx, tongue, or face muscles. This may result from CRANIAL NERVE DISEASES; NEUROMUSCULAR DISEASES; CEREBELLAR DISEASES; BASAL GANGLIA DISEASES; BRAIN STEM diseases; or diseases of the corticobulbar tracts (see PYRAMIDAL TRACTS). The cortical language centers are intact in this condition. (From Adams et al., Principles of Neurology, 6th ed, p489)	""	0	#FFFFFF
D004402	C10.177.575.300|C10.500.250.309|C10.574.500.493.250|C10.668.829.800.175.250|C16.131.666.310.309|C16.320.400.415.309	Dysautonomia, Familial	An autosomal disorder of the peripheral and autonomic nervous systems limited to individuals of Ashkenazic Jewish descent. Clinical manifestations are present at birth and include diminished lacrimation, defective thermoregulation, orthostatic hypotension (HYPOTENSION, ORTHOSTATIC), fixed pupils, excessive SWEATING, loss of pain and temperature sensation, and absent reflexes. Pathologic features include reduced numbers of small diameter peripheral nerve fibers and autonomic ganglion neurons. (From Adams et al., Principles of Neurology, 6th ed, p1348; Nat Genet 1993;4(2):160-4)	""	0	#FFFFFF
D004403	C06.405.205.331|C06.405.469.300	Dysentery	Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.	""	0	#FFFFFF
D004404	C01.610.432.396|C01.610.752.049.328|C06.405.205.331.312|C06.405.469.300.312|C06.405.469.452.396	Dysentery, Amebic	DYSENTERY caused by intestinal amebic infection, chiefly with ENTAMOEBA HISTOLYTICA. This condition may be associated with amebic infection of the LIVER and other distant sites.	""	0	#FFFFFF
D004405	C01.150.252.400.310.229|C06.405.205.331.479|C06.405.469.300.479	Dysentery, Bacillary	DYSENTERY caused by gram-negative rod-shaped enteric bacteria (ENTEROBACTERIACEAE), most often by the genus SHIGELLA. Shigella dysentery, Shigellosis, is classified into subgroups according to syndrome severity and the infectious species. Group A: SHIGELLA DYSENTERIAE (severest); Group B: SHIGELLA FLEXNERI; Group C: SHIGELLA BOYDII; and Group D: SHIGELLA SONNEI (mildest).	""	0	#FFFFFF
D004406	C15.378.147.333|C20.673.430	Dysgammaglobulinemia	An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins.	""	0	#FFFFFF
D004407	C04.557.465.330.300	Dysgerminoma	A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)	""	0	#FFFFFF
D004408	C10.597.751.861.479|C23.888.592.763.861.479	Dysgeusia	A condition characterized by alterations of the sense of taste which may range from mild to severe, including gross distortions of taste quality.	""	0	#FFFFFF
D004409	C10.228.662.262.500|C10.597.350.275|C10.720.312|C23.888.592.350.275|C25.100.750|C25.723.705.200	Dyskinesia, Drug-Induced	Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)	""	0	#FFFFFF
D004410	C10.597.606.150.500.300|C10.597.606.150.550.200|C23.888.592.604.150.500.300|C23.888.592.604.150.550.200	Dyslexia	A cognitive disorder characterized by an impaired ability to comprehend written and printed words or phrases despite intact vision. This condition may be developmental or acquired. Developmental dyslexia is marked by reading achievement that falls substantially below that expected given the individual's chronological age, measured intelligence, and age-appropriate education. The disturbance in reading significantly interferes with academic achievement or with activities of daily living that require reading skills. (From DSM-IV)	""	0	#FFFFFF
D004411	C10.597.606.150.500.300.200|C10.597.606.150.550.200.500|C23.888.592.604.150.500.300.200|C23.888.592.604.150.550.200.500	Dyslexia, Acquired	A receptive visual aphasia characterized by the loss of a previously possessed ability to comprehend the meaning or significance of handwritten words, despite intact vision. This condition may be associated with posterior cerebral artery infarction (INFARCTION, POSTERIOR CEREBRAL ARTERY) and other BRAIN DISEASES.	""	0	#FFFFFF
D004412	C23.550.568.750|C23.888.592.612.944.500	Dysmenorrhea	Painful menstruation.	""	0	#FFFFFF
D004413	C05.116.099.370	Dysostoses	Defective bone formation involving individual bones, singly or in combination.	""	0	#FFFFFF
D004414	C12.050.351.500.110|C12.100.250.110|C12.100.500.100|C12.100.875.242|C12.200.294.100	Dyspareunia	Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.	""	0	#FFFFFF
D004415	C23.888.821.236	Dyspepsia	Impaired digestion, especially after eating.	""	0	#FFFFFF
D004416	C04.557.665.560.260|C04.700.305|C16.320.700.305	Dysplastic Nevus Syndrome	Clinically atypical nevi (usually exceeding 5 mm in diameter and having variable pigmentation and ill defined borders) with an increased risk for development of non-familial cutaneous malignant melanoma. Biopsies show melanocytic dysplasia. Nevi are clinically and histologically identical to the precursor lesions for melanoma in the B-K mole syndrome. (Stedman, 25th ed)	""	0	#FFFFFF
D004417	C08.618.326|C23.888.852.371	Dyspnea	Difficult or labored breathing.	""	0	#FFFFFF
D004418	C08.618.326.396|C14.280.434.313|C23.888.852.371.396	Dyspnea, Paroxysmal	A disorder characterized by sudden attacks of respiratory distress in at rest patients with HEART FAILURE and PULMONARY EDEMA. It usually occurs at night after several hours of sleep in a reclining position. Patients awaken with a feeling of suffocation, coughing, a cold sweat, and TACHYCARDIA. When there is significant WHEEZING, it is called cardiac asthma.	""	0	#FFFFFF
D004420	C12.050.703.420.288	Dystocia	Slow or difficult OBSTETRIC LABOR or CHILDBIRTH.	""	0	#FFFFFF
D004421	C10.597.350.300|C23.888.592.350.300	Dystonia	An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)	""	0	#FFFFFF
D004422	C10.228.140.079.357|C10.228.662.300.200|C10.574.500.393|C16.320.400.330	Dystonia Musculorum Deformans	A condition characterized by focal DYSTONIA that progresses to involuntary spasmodic contractions of the muscles of the legs, trunk, arms, and face. The hands are often spared, however, sustained axial and limb contractions may lead to a state where the body is grossly contorted. Onset is usually in the first or second decade. Familial patterns of inheritance, primarily autosomal dominant with incomplete penetrance, have been identified. (Adams et al., Principles of Neurology, 6th ed, p1078)	""	0	#FFFFFF
D004426	C09.218.271	Ear Deformities, Acquired	Distortion or disfigurement of the ear caused by disease or injury after birth.	""	0	#FFFFFF
D004427	C09.218	Ear Diseases	Pathological processes of the ear, the hearing, and the equilibrium system of the body.	""	0	#FFFFFF
D004428	C04.588.443.665.312|C09.218.334|C09.647.312	Ear Neoplasms	Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).	""	0	#FFFFFF
D004433	C09.218.350|C23.888.592.612.302	Earache	Pain in the ear.	""	0	#FFFFFF
D004437	C14.240.400.395|C14.280.400.395|C16.131.240.400.395	Ebstein Anomaly	A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and posterior leaflets being attached to the wall of the RIGHT VENTRICLE. It is characterized by a huge RIGHT ATRIUM and a small and less effective right ventricle.	""	0	#FFFFFF
D004438	C15.378.100.452|C23.550.414.625|C23.888.885.312	Ecchymosis	Extravasation of blood into the skin, resulting in a nonelevated, rounded or irregular, blue or purplish patch, larger than a petechia.	""	0	#FFFFFF
D004443	C01.610.335.190.396	Echinococcosis	An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.	""	0	#FFFFFF
D004444	C01.610.335.190.396.314|C01.610.518.314|C06.552.664.272	Echinococcosis, Hepatic	Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST).	""	0	#FFFFFF
D004445	C01.610.335.190.396.480|C01.610.582.314|C01.748.450.314|C08.381.517.314|C08.730.450.314	Echinococcosis, Pulmonary	Helminth infection of the lung caused by Echinococcus granulosus or Echinococcus multilocularis.	""	0	#FFFFFF
D004451	C01.610.335.865.282	Echinostomiasis	Infection by flukes of the genus Echinostoma.	""	0	#FFFFFF
D004454	C10.597.606.150.500.800.300|C23.888.592.604.150.500.800.300	Echolalia	"Involuntary (""parrot-like""), meaningless repetition of a recently heard word, phrase, or song. This condition may be associated with transcortical APHASIA; SCHIZOPHRENIA; or other disorders. (From Adams et al., Principles of Neurology, 6th ed, p485)"	""	0	#FFFFFF
D004457	C01.925.782.687.359.347	Echovirus Infections	Infectious disease processes, including meningitis, diarrhea, and respiratory disorders, caused by echoviruses.	""	0	#FFFFFF
D004461	C12.050.703.395.124	Eclampsia	Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).	""	0	#FFFFFF
D004473	C01.150.252.410.890.168|C01.150.252.819.210|C01.800.720.210|C17.800.695.210|C17.800.838.765.210	Ecthyma	An ulcerative pyoderma usually caused by group A beta-hemolytic streptococcal infection at the site of minor trauma. (Dorland, 27th ed)	""	0	#FFFFFF
D004474	C01.925.256.743.193|C22.836.259	Ecthyma, Contagious	An infectious dermatitis of sheep and goats, affecting primarily the muzzle and lips. It is caused by a poxvirus and may be transmitted to man.	""	0	#FFFFFF
D004476	C16.131.077.350|C16.131.831.350|C16.320.850.250|C17.800.804.350|C17.800.827.250	Ectodermal Dysplasia	A group of hereditary disorders involving tissues and structures derived from the embryonic ectoderm. They are characterized by the presence of abnormalities at birth and involvement of both the epidermis and skin appendages. They are generally nonprogressive and diffuse. Various forms exist, including anhidrotic and hidrotic dysplasias, FOCAL DERMAL HYPOPLASIA, and aplasia cutis congenita.	""	0	#FFFFFF
D004478	C01.610.858.211	Ectoparasitic Infestations	Infestations by PARASITES which live on, or burrow into, the surface of their host's EPIDERMIS. Most ectoparasites are ARTHROPODS.	""	0	#FFFFFF
D004479	C11.250.300|C11.510.598.373|C16.131.384.405	Ectopia Lentis	Congenital displacement of the lens resulting from defective zonule formation.	""	0	#FFFFFF
D004480	C05.660.585.350|C16.131.621.585.350	Ectromelia	Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia.	""	0	#FFFFFF
D004482	C01.925.256.743.239|C22.795.239	Ectromelia, Infectious	A viral infection of mice, causing edema and necrosis followed by limb loss.	""	0	#FFFFFF
D004483	C11.338.362	Ectropion	The turning outward (eversion) of the edge of the eyelid, resulting in the exposure of the palpebral conjunctiva. (Dorland, 27th ed)	""	0	#FFFFFF
D004485	C17.800.174.620|C17.800.815.620	Eczema	A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).	""	0	#FFFFFF
D004487	C23.888.277	Edema	Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	""	0	#FFFFFF
D004488	C22.905.260	Edema Disease of Swine	An acute disease of young pigs that is usually associated with weaning. It is characterized clinically by paresis and subcutaneous edema.	""	0	#FFFFFF
D004489	C14.280.434.482|C23.888.277.197	Edema, Cardiac	Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).	""	0	#FFFFFF
D004535	C14.907.454.240|C15.378.463.515.240|C16.131.831.428|C16.320.850.260|C17.300.200.310|C17.800.804.428|C17.800.827.260	Ehlers-Danlos Syndrome	A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.	""	0	#FFFFFF
D004541	C14.240.400.450|C14.280.400.450|C16.131.240.400.450	Eisenmenger Complex	A condition associated with VENTRICULAR SEPTAL DEFECT and other congenital heart defects that allow the mixing of pulmonary and systemic circulation, increase blood flow into the lung, and subsequent responses to low oxygen in blood. This complex is characterized by progressive PULMONARY HYPERTENSION; HYPERTROPHY of the RIGHT VENTRICLE; CYANOSIS; and ERYTHROCYTOSIS.	""	0	#FFFFFF
D004556	C26.324	Electric Injuries	Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.	""	0	#FFFFFF
D004604	C15.604.496.320	Elephantiasis	Hypertrophy and thickening of tissues from causes other than filarial infection, the latter being described as ELEPHANTIASIS, FILARIAL.	""	0	#FFFFFF
D004605	C01.610.335.508.700.750.361.350|C01.920.750|C15.604.496.490	Elephantiasis, Filarial	Parasitic infestation of the human lymphatic system by WUCHERERIA BANCROFTI or BRUGIA MALAYI. It is also called lymphatic filariasis.	""	0	#FFFFFF
D004612	C15.378.071.141.150.365|C16.320.070.365	Elliptocytosis, Hereditary	An intrinsic defect of erythrocytes inherited as an autosomal dominant trait. The erythrocytes assume an oval or elliptical shape.	""	0	#FFFFFF
D004613	C05.116.099.708.327|C16.131.077.350.398|C16.131.831.350.398|C16.320.850.250.398|C17.800.804.350.398|C17.800.827.250.398	Ellis-Van Creveld Syndrome	Dwarfism occurring in association with defective development of skin, hair, and teeth, polydactyly, and defect of the cardiac septum. (Dorland, 27th ed)	""	0	#FFFFFF
D004614	C23.888.144.243.963.500	Emaciation	Clinical manifestation of excessive LEANNESS usually caused by disease or a lack of nutrition (MALNUTRITION).	""	0	#FFFFFF
D004617	C14.907.355.350	Embolism	Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.	""	0	#FFFFFF
D004618	C14.907.355.350.254	Embolism, Air	Blocking of a blood vessel by air bubbles that enter the circulatory system, usually after TRAUMA; surgical procedures, or changes in atmospheric pressure.	""	0	#FFFFFF
D004619	C12.050.703.634.404|C14.583.404|C14.907.355.350.354	Embolism, Amniotic Fluid	Blocking of maternal circulation by AMNIOTIC FLUID that is forced into uterine VEINS by strong UTERINE CONTRACTION near the end of pregnancy. It is characterized by the sudden onset of severe respiratory distress and HYPOTENSION that can lead to maternal DEATH.	""	0	#FFFFFF
D004620	C14.907.355.350.454	Embolism, Fat	Blocking of a blood vessel by fat deposits in the circulation. It is often seen after fractures of large bones or after administration of CORTICOSTEROIDS.	""	0	#FFFFFF
D004630	C23.550.291.781	Emergencies	Situations or conditions requiring immediate intervention to avoid serious adverse results.	""	0	#FFFFFF
D004646	C23.550.325	Emphysema	A pathological accumulation of air in tissues or organs.	""	0	#FFFFFF
D004652	C10.228.140.617.738.200|C19.700.320	Empty Sella Syndrome	A condition when the SELLA TURCICA is not filled with pituitary tissue. The pituitary gland is either compressed, atrophied, or removed. There are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of PITUITARY NEOPLASMS.	""	0	#FFFFFF
D004653	C01.830.305|C23.550.470.756.305	Empyema	Presence of pus in a hollow organ or body cavity.	""	0	#FFFFFF
D004654	C01.748.265.320|C01.748.912.405|C01.830.305.310.320|C08.528.240.320|C08.528.928.405|C08.730.265.320|C08.730.912.405|C23.550.470.756.305.250.320	Empyema, Tuberculous	Empyema due to MYCOBACTERIUM TUBERCULOSIS.	""	0	#FFFFFF
D004660	C10.228.140.430|C10.586.250	Encephalitis	Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.	""	0	#FFFFFF
D004670	C01.207.245.340.300.200|C01.207.399.750.300.200|C01.920.500.343.340|C01.925.081.343.340|C01.925.182.525.300.200|C01.925.782.147.340|C01.925.782.310.340|C10.228.140.430.520.750.300.200|C10.228.228.245.340.300.200|C10.228.228.399.750.300.200|C10.586.250.520.750.300.200	Encephalitis, California	A viral infection of the brain caused by serotypes of California encephalitis virus (ENCEPHALITIS VIRUS, CALIFORNIA) transmitted to humans by the mosquito AEDES triseriatus. The majority of cases are caused by the LA CROSSE VIRUS. This condition is endemic to the midwestern United States and primarily affects children between 5-10 years of age. Clinical manifestations include FEVER; VOMITING; HEADACHE; and abdominal pain followed by SEIZURES, altered mentation, and focal neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13)	""	0	#FFFFFF
D004671	C01.207.245.340.300|C01.207.399.750.300|C01.920.500.343|C01.925.081.343|C01.925.182.525.300|C01.925.782.310|C10.228.140.430.520.750.300|C10.228.228.245.340.300|C10.228.228.399.750.300|C10.586.250.520.750.300	Encephalitis, Arbovirus	Infections of the brain caused by arthropod-borne viruses (i.e., arboviruses) primarily from the families TOGAVIRIDAE; FLAVIVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; and RHABDOVIRIDAE. Life cycles of these viruses are characterized by ZOONOSES, with birds and lower mammals serving as intermediate hosts. The virus is transmitted to humans by the bite of mosquitoes (CULICIDAE) or TICKS. Clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)	""	0	#FFFFFF
D004672	C01.207.245.340.300.400|C01.207.399.750.300.400|C01.920.500.343.345|C01.925.081.343.345|C01.925.182.525.300.250|C01.925.782.310.345|C01.925.782.350.250.300|C10.228.140.430.520.750.300.400|C10.228.228.245.340.300.400|C10.228.228.399.750.300.400|C10.586.250.520.750.300.400	Encephalitis, Japanese	A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)	""	0	#FFFFFF
D004673	C10.114.375.225|C10.228.140.695.562.225|C10.314.350.225|C20.111.258.250.350	Encephalomyelitis, Acute Disseminated	An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)	""	0	#FFFFFF
D004674	C01.207.245.340.300.550|C01.207.399.750.300.550|C01.920.500.343.350|C01.925.081.343.350|C01.925.182.525.300.300|C01.925.782.310.350|C01.925.782.350.250.450|C10.228.140.430.520.750.300.550|C10.228.228.245.340.300.550|C10.228.228.399.750.300.550|C10.586.250.520.750.300.550	Encephalitis, St. Louis	A viral encephalitis caused by the St. Louis encephalitis virus (ENCEPHALITIS VIRUS, ST. LOUIS), a FLAVIVIRUS. It is transmitted to humans and other vertebrates primarily by mosquitoes of the genus CULEX. The primary animal vectors are wild birds and the disorder is endemic to the midwestern and southeastern United States. Infections may be limited to an influenza-like illness or present as an ASEPTIC MENINGITIS or ENCEPHALITIS. Clinical manifestations of the encephalitic presentation may include SEIZURES, lethargy, MYOCLONUS, focal neurologic signs, COMA, and DEATH. (From Adams et al., Principles of Neurology, 6th ed, p750)	""	0	#FFFFFF
D004675	C01.207.245.340.300.775|C01.207.399.750.300.775|C01.920.500.343.360|C01.920.930.400|C01.925.081.343.360|C01.925.182.525.300.350|C01.925.782.310.360|C01.925.782.350.250.500|C10.228.140.430.520.750.300.775|C10.228.228.245.340.300.775|C10.228.228.399.750.300.775|C10.586.250.520.750.300.775	Encephalitis, Tick-Borne	Encephalitis caused by neurotropic viruses that are transmitted via the bite of TICKS. In Europe, the diseases are caused by ENCEPHALITIS VIRUSES, TICK-BORNE, which give rise to Russian spring-summer encephalitis, central European encephalitis, louping ill encephalitis, and related disorders. Powassan encephalitis occurs in North America and Russia and is caused by the Powassan virus. ASEPTIC MENINGITIS and rarely encephalitis may complicate COLORADO TICK FEVER which is endemic to mountainous regions of the western United States. (From Joynt, Clinical Neurology, 1996, Ch26, pp14-5)	""	0	#FFFFFF
D004677	C10.500.680.488|C16.131.666.680.488|C23.300.707.186	Encephalocele	Brain tissue herniation through a congenital or acquired defect in the skull. The majority of congenital encephaloceles occur in the occipital or frontal regions. Clinical features include a protuberant mass that may be pulsatile. The quantity and location of protruding neural tissue determines the type and degree of neurologic deficit. Visual defects, psychomotor developmental delay, and persistent motor deficits frequently occur.	""	0	#FFFFFF
D004678	C10.228.140.461	Encephalomalacia	Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)	""	0	#FFFFFF
D004679	C01.207.291|C10.228.228.291|C10.586.500	Encephalomyelitis	A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.	""	0	#FFFFFF
D004681	C10.114.703.300|C10.228.140.695.562.250|C10.314.350.250|C20.111.258.625.300	Encephalomyelitis, Autoimmune, Experimental	An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)	""	0	#FFFFFF
D004682	C01.925.782.687.359.456|C22.905.323	Encephalomyelitis, Enzootic Porcine	A picornavirus infection producing symptoms similar to poliomyelitis in pigs.	""	0	#FFFFFF
D004683	C01.207.245.340.450|C01.207.291.323|C01.207.399.750.450|C01.920.500.078.370|C01.920.500.343.655|C01.925.081.343.655|C01.925.182.525.450|C01.925.782.930.100.370|C10.228.140.430.520.750.450|C10.228.228.245.340.450|C10.228.228.291.323|C10.228.228.399.750.450|C10.586.250.520.750.450|C10.586.500.406	Encephalomyelitis, Equine	A group of ALPHAVIRUS INFECTIONS which affect horses and man, transmitted via the bites of mosquitoes. Disorders in this category are endemic to regions of South America and North America. In humans, clinical manifestations vary with the type of infection, and range from a mild influenza-like syndrome to a fulminant encephalitis. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-10)	""	0	#FFFFFF
D004684	C10.114.375.225.500|C10.114.375.362|C10.228.140.695.562.225.500|C10.228.140.695.562.375|C10.314.350.225.500|C10.314.350.375|C20.111.258.250.350.500|C20.111.258.250.425	Leukoencephalitis, Acute Hemorrhagic	A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid onset of weakness, SEIZURES, and COMA. It may follow a viral illness or MYCOPLASMA PNEUMONIAE infections but in most instances there is no precipitating event. Pathologic examination reveals marked perivascular demyelination and necrosis of white matter with microhemorrhages. (Adams et al., Principles of Neurology, 6th ed, pp924-5)	""	0	#FFFFFF
D004685	C01.207.245.340.450.600|C01.207.291.323.325|C01.207.399.750.450.600|C01.920.500.078.370.325|C01.920.500.343.655.355|C01.925.081.343.655.355|C01.925.182.525.450.250|C01.925.782.930.100.370.325|C10.228.140.430.520.750.450.600|C10.228.228.245.340.450.600|C10.228.228.291.323.325|C10.228.228.399.750.450.600|C10.586.250.520.750.450.600|C10.586.500.406.225	Encephalomyelitis, Venezuelan Equine	A form of arboviral encephalitis endemic to Central America and the northern latitudes of South America. The causative organism (ENCEPHALITIS VIRUS, VENEZUELAN EQUINE) is transmitted to humans and horses via the bite of several mosquito species. Human viral infection may be asymptomatic or remain restricted to a mild influenza-like illness. Encephalitis, usually not severe, occurs in a small percentage of cases and may rarely feature SEIZURES and COMA. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)	""	0	#FFFFFF
D004687	C05.116.099.708.338	Enchondromatosis	Benign growths of cartilage in the metaphyses of several bones.	""	0	#FFFFFF
D004688	C23.888.821.266	Encopresis	Incontinence of feces not due to organic defect or illness.	""	0	#FFFFFF
D004692	C14.907.940.090.340	Endarteritis	Inflammation of the inner endothelial lining (TUNICA INTIMA) of an artery.	""	0	#FFFFFF
D004694	C14.240.400.560.350|C14.280.400.560.350|C16.131.240.400.560.350	Endocardial Cushion Defects	A spectrum of septal defects involving the ATRIAL SEPTUM; VENTRICULAR SEPTUM; and the atrioventricular valves (TRICUSPID VALVE; BICUSPID VALVE). These defects are due to incomplete growth and fusion of the ENDOCARDIAL CUSHIONS which are important in the formation of two atrioventricular canals, site of future atrioventricular valves.	""	0	#FFFFFF
D004695	C14.280.238.281	Endocardial Fibroelastosis	A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.	""	0	#FFFFFF
D004696	C14.280.282	Endocarditis	Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening.	""	0	#FFFFFF
D004697	C01.150.252.245|C01.190.249|C14.260.249|C14.280.282.407	Endocarditis, Bacterial	Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.	""	0	#FFFFFF
D004698	C01.150.252.245.500|C01.150.252.410.890.335|C01.190.249.407|C14.260.249.407|C14.280.282.407.407	Endocarditis, Subacute Bacterial	ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.	""	0	#FFFFFF
D004700	C19	Endocrine System Diseases	Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.	""	0	#FFFFFF
D004701	C04.588.322|C19.344	Endocrine Gland Neoplasms	Tumors or cancer of the ENDOCRINE GLANDS.	""	0	#FFFFFF
D004714	C12.050.351.500.852.228|C12.100.250.852.228	Endometrial Hyperplasia	Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.	""	0	#FFFFFF
D004715	C12.050.351.500.163|C12.100.250.163	Endometriosis	A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.	""	0	#FFFFFF
D004716	C12.050.351.500.056.750.249|C12.050.351.500.852.299|C12.100.250.056.750.249|C12.100.250.852.299	Endometritis	Inflammation of the ENDOMETRIUM, usually caused by intrauterine infections. Endometritis is the most common cause of postpartum fever.	""	0	#FFFFFF
D004719	C14.280.238.406	Endomyocardial Fibrosis	A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).	""	0	#FFFFFF
D004749	C01.610.752.049.407	Entamoebiasis	Infection with amoebae of the genus ENTAMOEBA. Infection with E. histolytica causes DYSENTERY, AMEBIC and LIVER ABSCESS, AMEBIC.	""	0	#FFFFFF
D004751	C06.405.205.462|C06.405.469.326	Enteritis	Inflammation of any segment of the SMALL INTESTINE.	""	0	#FFFFFF
D004753	C01.925.782.600.550.200.325|C22.131.728.250	Enteritis, Transmissible, of Turkeys	An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.	""	0	#FFFFFF
D004756	C01.150.252.400.310	Enterobacteriaceae Infections	Infections with bacteria of the family ENTEROBACTERIACEAE.	""	0	#FFFFFF
D004760	C06.405.205.596|C06.405.469.363	Enterocolitis	Inflammation of the MUCOSA of both the SMALL INTESTINE and the LARGE INTESTINE. Etiology includes ISCHEMIA, infections, allergic, and immune responses.	""	0	#FFFFFF
D004761	C01.150.252.410.222.310|C06.405.205.596.800|C06.405.469.363.800	Enterocolitis, Pseudomembranous	An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.	""	0	#FFFFFF
D004767	C01.150.252.410.222.325|C22.313	Enterotoxemia	"Disease caused by the liberation of exotoxins of CLOSTRIDIUM PERFRINGENS in the intestines of sheep, goats, cattle, foals, and piglets. Type B enterotoxemia in lambs is lamb dysentery; type C enterotoxemia in mature sheep produces ""struck"", and in calves, lambs and piglets it produces hemorrhagic enterotoxemia; type D enterotoxemia in sheep and goats is pulpy-kidney disease or overeating disease."	""	0	#FFFFFF
D004769	C01.925.782.687.359	Enterovirus Infections	Diseases caused by ENTEROVIRUS.	""	0	#FFFFFF
D004774	C11.338.443	Entropion	The turning inward (inversion) of the edge of the eyelid, with the tarsal cartilage turned inward toward the eyeball. (Dorland, 27th ed)	""	0	#FFFFFF
D004775	C12.050.351.968.934.252|C12.200.777.934.284|C12.950.934.252	Enuresis	Involuntary discharge of URINE after expected age of completed development of urinary control. This can happen during the daytime (DIURNAL ENURESIS) while one is awake or during sleep (NOCTURNAL ENURESIS). Enuresis can be in children or in adults (as persistent primary enuresis and secondary adult-onset enuresis).	""	0	#FFFFFF
D004802	C15.378.553.231	Eosinophilia	Abnormal increase of EOSINOPHILS in the blood, tissues or organs.	""	0	#FFFFFF
D004803	C05.116.391|C08.381.483.375.500|C15.378.553.231.348|C15.604.250.400.360|C23.550.382.250	Eosinophilic Granuloma	The most benign and common form of Langerhans-cell histiocytosis which involves localized nodular lesions predominantly of the bones but also of the gastric mucosa, small intestine, lungs, or skin, with infiltration by EOSINOPHILS.	""	0	#FFFFFF
D004806	C04.557.465.625.600.380.290|C04.557.470.670.380.290|C04.557.580.625.600.380.290	Ependymoma	Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)	""	0	#FFFFFF
D004810	C01.925.782.580.830.375|C22.196.274	Ephemeral Fever	An Ephemerovirus infection of cattle caused by bovine ephemeral fever virus (EPHEMERAL FEVER VIRUS, BOVINE). It is characterized by respiratory symptoms, increased oropharyngeal secretions and lacrimation, joint pains, tremor, and stiffness.	""	0	#FFFFFF
D004814	C04.182.254	Epidermal Cyst	Intradermal or subcutaneous saclike structure, the wall of which is stratified epithelium containing keratohyalin granules.	""	0	#FFFFFF
D004818	C22.905.382	Epidermitis, Exudative, of Swine	An acute generalized dermatitis of pigs which occurs from 5 to 35 days of age, characterized by sudden onset, with morbidity of 10 to 90% and mortality of 5 to 90%. The lesions are caused by Staphylococcus hyos but the bacterial agent is unable to penetrate the intact skin. Abrasions on the feet and legs or lacerations on the body frequently precede infection. In acute cases, a vesicular-type virus may be the predisposing factor. The causative organism is inhibited by most antibiotics. (Merck Veterinary Manual, 5th ed)	""	0	#FFFFFF
D004819	C01.925.256.650.810.345|C01.925.825.810.260|C01.925.928.914.345|C17.800.838.790.810.260	Epidermodysplasia Verruciformis	An autosomal recessive trait with impaired cell-mediated immunity. About 15 human papillomaviruses are implicated in associated infection, four of which lead to skin neoplasms. The disease begins in childhood with red papules and later spreads over the body as gray or yellow scales.	""	0	#FFFFFF
D004820	C16.131.831.493|C16.320.850.275|C17.800.804.493|C17.800.827.275|C17.800.865.410	Epidermolysis Bullosa	Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.	""	0	#FFFFFF
D004823	C12.100.500.199|C12.200.294.199	Epididymitis	Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.	""	0	#FFFFFF
D004826	C01.748.798.200|C08.730.798.200	Epiglottitis	Inflammation of the EPIGLOTTIS.	""	0	#FFFFFF
D004827	C10.228.140.490	Epilepsy	A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)	""	0	#FFFFFF
D004828	C10.228.140.490.360	Epilepsies, Partial	Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)	""	0	#FFFFFF
D004829	C10.228.140.490.375	Epilepsy, Generalized	Recurrent conditions characterized by epileptic seizures which arise diffusely and simultaneously from both hemispheres of the brain. Classification is generally based upon motor manifestations of the seizure (e.g., convulsive, nonconvulsive, akinetic, atonic, etc.) or etiology (e.g., idiopathic, cryptogenic, and symptomatic). (From Mayo Clin Proc, 1996 Apr;71(4):405-14)	""	0	#FFFFFF
D004830	C10.228.140.490.375.290	Epilepsy, Tonic-Clonic	A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)	""	0	#FFFFFF
D004831	C10.228.140.490.375.130|C10.228.140.490.493.063	Epilepsies, Myoclonic	A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic.	""	0	#FFFFFF
D004832	C10.228.140.490.375.260|C10.228.140.490.493.125	Epilepsy, Absence	A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)	""	0	#FFFFFF
D004833	C10.228.140.490.360.290|C10.228.140.490.493.375	Epilepsy, Temporal Lobe	A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).	""	0	#FFFFFF
D004834	C10.228.140.199.650|C10.228.140.490.380|C10.900.300.087.600|C26.915.300.200.475	Epilepsy, Post-Traumatic	Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)	""	0	#FFFFFF
D004839	C05.116.425	Epiphyses, Slipped	A complete or partial separation of the EPIPHYSES from the DIAPHYSES.	""	0	#FFFFFF
D004842	C12.050.351.875.374|C12.050.351.968.767.374|C12.200.706.374|C12.200.777.767.374|C12.800.374|C12.950.767.374|C16.131.939.374	Epispadias	A birth defect due to malformation of the URETHRA in which the urethral opening is above its normal location. In the male, the malformed urethra generally opens on the top or the side of the PENIS, but the urethra can also be open the entire length of the penis. In the female, the malformed urethral opening is often between the CLITORIS and the labia, or in the ABDOMEN.	""	0	#FFFFFF
D004844	C08.460.261|C09.603.261|C23.550.414.712|C23.888.852.040	Epistaxis	Bleeding from the nose.	""	0	#FFFFFF
D004859	C01.925.782.815.616.300|C01.925.839.375|C22.488.304	Equine Infectious Anemia	Viral disease of horses caused by the equine infectious anemia virus (EIAV; INFECTIOUS ANEMIA VIRUS, EQUINE). It is characterized by intermittent fever, weakness, and anemia. Chronic infection consists of acute episodes with remissions.	""	0	#FFFFFF
D004863	C05.330.488.655.125|C05.330.495.681.125|C05.660.585.512.380.813.125|C16.131.621.585.512.500.681.125	Equinus Deformity	Plantar declination of the foot.	""	0	#FFFFFF
D004881	C25.723.680.262	Ergotism	Poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.	""	0	#FFFFFF
D004884	C23.888.821.297	Eructation	The ejection of gas or air through the mouth from the stomach.	""	0	#FFFFFF
D004886	C01.150.252.410.890.503|C01.150.252.819.260|C01.800.720.260|C17.800.838.765.260	Erysipelas	An acute infection of the skin caused by species of STREPTOCOCCUS. This disease most frequently affects infants, young children, and the elderly. Characteristics include pink-to-red lesions that spread rapidly and are warm to the touch. The commonest site of involvement is the face.	""	0	#FFFFFF
D004887	C01.150.252.410.334.329	Erysipeloid	An infection caused by Erysipelothrix rhusiopathiae that is almost wholly restricted to persons who in their occupation handle infected fish, shellfish, poultry, or meat. Three forms of this condition exist: a mild localized form manifested by local swelling and redness of the skin; a diffuse form that might present with fever; and a rare systemic form associated with endocarditis.	""	0	#FFFFFF
D004889	C01.150.252.410.334|C22.331	Erysipelothrix Infections	Infections with bacteria of the genus ERYSIPELOTHRIX.	""	0	#FFFFFF
D004890	C17.800.229|C23.888.885.328	Erythema	Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	""	0	#FFFFFF
D004891	C01.150.252.819.820.260|C01.800.720.820.260|C17.300.710.329|C17.800.229.329|C17.800.566.329|C17.800.838.765.820.320	Erythema Induratum	A type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis. It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent. It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves. The nodules may progress to form indurations, ulcerations, and scars.	""	0	#FFFFFF
D004892	C17.800.229.400|C17.800.865.475	Erythema Multiforme	"A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic ""bull's-eye"" lesions usually occurring on the dorsal aspect of the hands and forearms."	""	0	#FFFFFF
D004893	C17.800.174.600.375|C17.800.229.413|C20.543.206.380.375|C25.100.468.380.375	Erythema Nodosum	An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.	""	0	#FFFFFF
D004894	C01.150.252.410.040.246.694|C01.150.252.819.320|C01.800.720.320|C17.800.838.765.320	Erythrasma	A chronic bacterial infection of major folds of the skin, caused by Corynebacterium minutissimum.	""	0	#FFFFFF
D004899	C12.050.703.277.060|C15.378.295|C16.300.060|C16.614.304|C20.306	Erythroblastosis, Fetal	A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.	""	0	#FFFFFF
D004915	C04.557.337.539.275.325|C15.378.190.636.276	Leukemia, Erythroblastic, Acute	A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.	""	0	#FFFFFF
D004916	C14.907.617.500	Erythromelalgia	A peripheral arterial disease that is characterized by the triad of ERYTHEMA, burning PAIN, and increased SKIN TEMPERATURE of the extremities (or red, painful extremities). Erythromelalgia may be classified as primary or idiopathic, familial or non-familial. Secondary erythromelalgia is associated with other diseases, the most common being MYELOPROLIFERATIVE DISORDERS.	""	0	#FFFFFF
D004919	C04.834.288	Erythroplasia	A condition of the mucous membrane characterized by erythematous papular lesions.	""	0	#FFFFFF
D004927	C01.150.252.400.310.330	Escherichia coli Infections	Infections with bacteria of the species ESCHERICHIA COLI.	""	0	#FFFFFF
D004931	C06.405.117.119.500.432	Esophageal Achalasia	A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).	""	0	#FFFFFF
D004932	C06.405.117.240|C06.552.494.414	Esophageal and Gastric Varices	Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).	""	0	#FFFFFF
D004933	C06.198.330|C06.405.117.260|C16.131.314.330	Esophageal Atresia	Congenital abnormality characterized by the lack of full development of the ESOPHAGUS that commonly occurs with TRACHEOESOPHAGEAL FISTULA. Symptoms include excessive SALIVATION; GAGGING; CYANOSIS; and DYSPNEA.	""	0	#FFFFFF
D004934	C04.182.281|C06.405.117.316	Esophageal Cyst	Any fluid-filled closed cavity or sac (CYSTS) that is lined by an EPITHELIUM and found in the ESOPHAGUS region.	""	0	#FFFFFF
D004935	C06.405.117	Esophageal Diseases	Pathological processes in the ESOPHAGUS.	""	0	#FFFFFF
D004936	C06.405.205.282.750.625|C23.300.415.625	Diverticulum, Esophageal	Saccular protrusion beyond the wall of the ESOPHAGUS.	""	0	#FFFFFF
D004937	C06.267.250|C06.405.117.367|C23.300.575.185.250	Esophageal Fistula	Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.	""	0	#FFFFFF
D004938	C04.588.274.476.205|C04.588.443.353|C06.301.371.205|C06.405.117.430|C06.405.249.205	Esophageal Neoplasms	Tumors or cancer of the ESOPHAGUS.	""	0	#FFFFFF
D004939	C06.405.117.468|C26.348	Esophageal Perforation	An opening or hole in the ESOPHAGUS that is caused by TRAUMA, injury, or pathological process.	""	0	#FFFFFF
D004940	C06.405.117.544	Esophageal Stenosis	A stricture of the ESOPHAGUS. Most are acquired but can be congenital.	""	0	#FFFFFF
D004941	C06.405.117.620|C06.405.205.663	Esophagitis	INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.	""	0	#FFFFFF
D004942	C06.405.117.620.420|C06.405.205.663.420|C06.405.469.275.800.523|C06.405.748.586.524	Esophagitis, Peptic	INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM.	""	0	#FFFFFF
D004948	C10.292.562.887.300|C11.590.810.400	Esotropia	"A form of ocular misalignment characterized by an excessive convergence of the visual axes, resulting in a ""cross-eye"" appearance. An example of this condition occurs when paralysis of the lateral rectus muscle causes an abnormal inward deviation of one eye on attempted gaze."	""	0	#FFFFFF
D005058	C19.391.482.293	Eunuchism	The state of being a eunuch, a male without TESTES or whose testes failed to develop. It is characterized by the lack of mature male GERM CELLS and TESTICULAR HORMONES.	""	0	#FFFFFF
D005067	C19.874.255	Euthyroid Sick Syndromes	Conditions of abnormal THYROID HORMONES release in patients with apparently normal THYROID GLAND during severe systemic illness, physical TRAUMA, and psychiatric disturbances. It can be caused by the loss of endogenous hypothalamic input or by exogenous drug effects. The most common abnormality results in low T3 THYROID HORMONE with progressive decrease in THYROXINE; (T4) and TSH. Elevated T4 with normal T3 may be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased.	""	0	#FFFFFF
D005076	C17.800.257	Exanthema	Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.	""	0	#FFFFFF
D005077	C01.925.256.466.850.290|C01.925.825.290|C17.800.257.335|C17.800.838.790.290	Exanthema Subitum	An acute, short-lived, viral disease of infants and young children characterized by a high fever at onset that drops to normal after 3-4 days and the concomitant appearance of a macular or maculopapular rash that appears first on the trunk and then spreads to other areas. It is the sixth of the classical exanthematous diseases and is caused by HHV-6; (HERPESVIRUS 6, HUMAN). (From Dorland, 27th ed)	""	0	#FFFFFF
D005094	C11.675.349	Exophthalmos	Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.	""	0	#FFFFFF
D005096	C05.116.540.310	Exostoses	Benign hypertrophy that projects outward from the surface of bone, often containing a cartilaginous component.	""	0	#FFFFFF
D005097	C04.557.450.565.575.610.615.325|C04.700.330|C05.116.099.708.670.615.325|C05.116.540.310.500|C16.320.700.330	Exostoses, Multiple Hereditary	Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.	""	0	#FFFFFF
D005099	C10.292.562.887.650|C11.590.810.440	Exotropia	A form of ocular misalignment where the visual axes diverge inappropriately. For example, medial rectus muscle weakness may produce this condition as the affected eye will deviate laterally upon attempted forward gaze. An exotropia occurs due to the relatively unopposed force exerted on the eye by the lateral rectus muscle, which pulls the eye in an outward direction.	""	0	#FFFFFF
D005117	C14.280.067.325|C14.280.123.375|C23.550.073.325	Cardiac Complexes, Premature	A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atrial and ventricular premature beats, and are also known as extra or ectopic heartbeats. Their frequency is increased in heart diseases.	""	0	#FFFFFF
D005119	C23.550.340|C26.371	Extravasation of Diagnostic and Therapeutic Materials	The escape of diagnostic or therapeutic material from the vessel into which it is introduced into the surrounding tissue or body cavity.	""	0	#FFFFFF
D005124	C11.250|C16.131.384	Eye Abnormalities	Congenital absence of or defects in structures of the eye; may also be hereditary.	""	0	#FFFFFF
D005126	C10.900.300.284.250.250|C26.200.503|C26.915.300.425.250.250	Eye Burns	Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.	""	0	#FFFFFF
D005128	C11	Eye Diseases	Diseases affecting the eye.	""	0	#FFFFFF
D005129	C10.900.300.284.250.260|C26.392.421|C26.915.300.425.250.260	Eye Foreign Bodies	Inanimate objects that become enclosed in the eye.	""	0	#FFFFFF
D005130	C11.290|C23.550.414.756|C23.888.307.500	Eye Hemorrhage	Intraocular hemorrhage from the vessels of various tissues of the eye.	""	0	#FFFFFF
D005131	C10.900.300.284.250|C11.297|C26.915.300.425.250	Eye Injuries	Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.	""	0	#FFFFFF
D005132	C11.300|C23.888.307	Eye Manifestations	Ocular disorders attendant upon non-ocular disease or injury.	""	0	#FFFFFF
D005134	C04.588.364|C11.319	Eye Neoplasms	Tumors or cancer of the EYE.	""	0	#FFFFFF
D005141	C11.338	Eyelid Diseases	Diseases involving the EYELIDS.	""	0	#FFFFFF
D005142	C04.588.443.392.500|C11.319.421|C11.338.526	Eyelid Neoplasms	Tumors of cancer of the EYELIDS.	""	0	#FFFFFF
D005146	C23.300.505	Facial Asymmetry	Congenital or acquired asymmetry of the face.	""	0	#FFFFFF
D005148	C17.800.271	Facial Dermatoses	Skin diseases involving the FACE.	""	0	#FFFFFF
D005150	C07.465.284|C07.465.299.375|C10.292.319.375	Facial Hemiatrophy	A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.	""	0	#FFFFFF
D005151	C10.900.300.284|C26.915.300.425	Facial Injuries	General or unspecified injuries to the soft tissue or bony portions of the face.	""	0	#FFFFFF
D005153	C04.588.443.392	Facial Neoplasms	New abnormal growth of tissue in the FACE.	""	0	#FFFFFF
D005155	C07.465.299|C10.292.319	Facial Nerve Diseases	Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation.	""	0	#FFFFFF
D005156	C07.465.299.625|C10.292.319.625	Facial Neuralgia	Neuralgic syndromes which feature chronic or recurrent FACIAL PAIN as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions.	""	0	#FFFFFF
D005157	C23.888.592.612.330	Facial Pain	Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.	""	0	#FFFFFF
D005158	C07.465.327|C10.597.622.214|C23.888.592.636.214	Facial Paralysis	Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.	""	0	#FFFFFF
D005166	C15.378.100.100.300|C15.378.100.141.300|C15.378.463.300|C16.320.099.300	Factor V Deficiency	A deficiency of blood coagulation factor V (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren's disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait. (Dorland, 27th ed)	""	0	#FFFFFF
D005168	C15.378.100.100.310|C15.378.100.141.310|C15.378.463.310|C16.320.099.310	Factor VII Deficiency	An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.	""	0	#FFFFFF
D005171	C15.378.100.100.320|C15.378.100.141.320|C15.378.463.320|C16.320.099.320	Factor X Deficiency	Blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.	""	0	#FFFFFF
D005173	C15.378.100.100.325|C15.378.100.141.325|C15.378.463.325|C16.320.099.325	Factor XI Deficiency	A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.	""	0	#FFFFFF
D005175	C15.378.100.100.330|C15.378.100.141.330|C15.378.463.330|C16.320.099.330	Factor XII Deficiency	An absence or reduced level of blood coagulation factor XII. It normally occurs in the absence of patient or family history of hemorrhagic disorders and is marked by prolonged clotting time.	""	0	#FFFFFF
D005177	C15.378.100.100.335|C15.378.100.141.335|C15.378.463.335|C16.320.099.335	Factor XIII Deficiency	A deficiency of blood coagulation FACTOR XIII or fibrin stabilizing factor (FSF) that prevents blood clot formation and results in a clinical hemorrhagic diathesis.	""	0	#FFFFFF
D005183	C23.888.338	Failure to Thrive	A condition of substandard growth or diminished capacity to maintain normal function.	""	0	#FFFFFF
D005184	C12.050.351.500.056.390|C12.100.250.056.390	Fallopian Tube Diseases	Diseases involving the FALLOPIAN TUBES including neoplasms (FALLOPIAN TUBE NEOPLASMS); SALPINGITIS; tubo-ovarian abscess; and blockage.	""	0	#FFFFFF
D005185	C04.588.945.418.365|C12.050.351.500.056.390.390|C12.050.351.937.418.365|C12.100.250.056.390.390|C12.900.418.365	Fallopian Tube Neoplasms	Benign or malignant neoplasms of the FALLOPIAN TUBES. They are uncommon. If they develop, they may be located in the wall or within the lumen as a growth attached to the wall by a stalk.	""	0	#FFFFFF
D005198	C12.050.351.968.419.815.450|C12.200.777.419.815.450|C12.950.419.815.450|C16.320.831.450	Fanconi Syndrome	A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY GLOMERULUS. It is usually characterized by the tubular wasting of nutrients and salts (GLUCOSE; AMINO ACIDS; PHOSPHATES; and BICARBONATES) resulting in HYPOKALEMIA; ACIDOSIS; HYPERCALCIURIA; and PROTEINURIA.	""	0	#FFFFFF
D005199	C15.378.071.085.080.280|C15.378.190.223.500.500.280|C16.320.077.280|C18.452.284.280	Fanconi Anemia	Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	""	0	#FFFFFF
D005203	C08.381.483.125.365|C08.674.055.365|C20.543.480.680.075.365|C24.080.365	Farmer's Lung	A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.	""	0	#FFFFFF
D005207	C10.597.613.250|C23.888.592.608.250	Fasciculation	Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)	""	0	#FFFFFF
D005208	C05.321	Fasciitis	Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.	""	0	#FFFFFF
D005211	C01.610.335.865.354|C01.610.518.424|C06.552.664.424	Fascioliasis	Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.	""	0	#FFFFFF
D005213	C01.610.335.349.444|C01.610.335.865.399|C01.610.701.377.444|C22.674.377.444	Fascioloidiasis	Infection of cattle and other herbivores with the giant liver fluke Fascioloides magna. It is characterized by extensive destruction of the liver parenchyma.	""	0	#FFFFFF
D005218	C23.550.717.365	Fat Necrosis	A condition in which the death of adipose tissue results in neutral fats being split into fatty acids and glycerol.	""	0	#FFFFFF
D005221	C23.888.369	Fatigue	The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.	""	0	#FFFFFF
D005222	C23.888.369.500	Mental Fatigue	A condition of low alertness or cognitive impairment, usually associated with prolonged mental activities or stress.	""	0	#FFFFFF
D005234	C06.552.241	Fatty Liver	Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.	""	0	#FFFFFF
D005235	C06.552.241.390|C06.552.645.390|C25.775.100.087.645.390	Fatty Liver, Alcoholic	Lipid infiltration of the hepatic parenchymal cells that is due to ALCOHOL ABUSE. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of TRIGLYCERIDES accumulated.	""	0	#FFFFFF
D005236	C15.378.071.141.150.480.370|C15.378.071.141.370|C16.320.070.480.370|C25.723.415.341|C25.723.756.375	Favism	Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.	""	0	#FFFFFF
D005242	C06.405.469.860.300	Fecal Incontinence	Failure of voluntary control of the anal sphincters, with involuntary passage of feces and flatus.	""	0	#FFFFFF
D005244	C06.405.469.531.424	Fecal Impaction	Formation of a firm impassable mass of stool in the RECTUM or distal COLON.	""	0	#FFFFFF
D005254	C01.925.256.700.363|C22.180.460	Feline Panleukopenia	A highly contagious DNA virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. It is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. It is caused by FELINE PANLEUKOPENIA VIRUS or the closely related MINK ENTERITIS VIRUS or CANINE PARVOVIRUS.	""	0	#FFFFFF
D005258	C05.550.114.154.389|C05.799.114.389|C17.300.775.099.389|C20.111.199.389	Felty Syndrome	A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.	""	0	#FFFFFF
D005261	C12.050	Female Urogenital Diseases and Pregnancy Complications	Pathological processes of the female URINARY TRACT, the reproductive system (GENITALIA, FEMALE), and disorders related to PREGNANCY.	""	0	#FFFFFF
D005262	C23.888.378	Feminization	Development of female secondary SEX CHARACTERISTICS in the MALE. It is due to the effects of estrogenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs.	""	0	#FFFFFF
D005264	C26.404.061|C26.558.276	Femoral Fractures	Fractures of the femur.	""	0	#FFFFFF
D005265	C26.404.061.425.500|C26.531.750.500|C26.558.276.425.500	Femoral Neck Fractures	Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.	""	0	#FFFFFF
D005266	C04.588.149.276|C05.116.231.343	Femoral Neoplasms	New abnormal growth of tissue in the FEMUR.	""	0	#FFFFFF
D005271	C05.116.852.175|C23.550.717.732.368	Femur Head Necrosis	Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE.	""	0	#FFFFFF
D005311	C12.050.703.277.390|C16.300.420|C23.888.852.079.594	Fetal Hypoxia	Deficient oxygenation of FETAL BLOOD.	""	0	#FFFFFF
D005313	C12.050.703.223|C23.550.260.585	Fetal Death	Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.	""	0	#FFFFFF
D005315	C12.050.703.277|C16.300	Fetal Diseases	Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.	""	0	#FFFFFF
D005316	C23.888.380	Fetal Distress	A nonreassuring fetal status (NRFS) indicating that the FETUS is compromised (American College of Obstetricians and Gynecologists 1988). It can be identified by sub-optimal values in FETAL HEART RATE; oxygenation of FETAL BLOOD; and other parameters.	""	0	#FFFFFF
D005317	C12.050.703.277.370|C16.300.390|C23.550.393.450	Fetal Growth Retardation	Failure of a FETUS to attain expected GROWTH.	""	0	#FFFFFF
D005320	C12.050.703.170.500|C12.050.703.277.570|C12.050.703.726.570|C16.300.570|C19.246.099.968|C23.888.144.186.500	Fetal Macrosomia	A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.	""	0	#FFFFFF
D005322	C12.050.703.420.339	Fetal Membranes, Premature Rupture	Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.	""	0	#FFFFFF
D005327	C12.050.703.223.300|C23.550.260.585.260	Fetal Resorption	The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).	""	0	#FFFFFF
D005330	C15.378.071.363.344|C16.614.053.344	Fetofetal Transfusion	Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)	""	0	#FFFFFF
D005331	C15.378.071.363.511|C16.614.053.511	Fetomaternal Transfusion	Transplacental passage of fetal blood into the circulation of the maternal organism. (Dorland, 27th ed)	""	0	#FFFFFF
D005334	C23.888.119.344	Fever	An abnormal elevation of body temperature, usually as a result of a pathologic process.	""	0	#FFFFFF
D005335	C23.888.119.344.345	Fever of Unknown Origin	Fever in which the etiology cannot be ascertained.	""	0	#FFFFFF
D005348	C17.800.090.750	Fibrocystic Breast Disease	A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.	""	0	#FFFFFF
D005350	C04.557.450.565.590.340	Fibroma	A benign tumor of fibrous or fully developed connective tissue.	""	0	#FFFFFF
D005351	C07.465.525.304|C07.465.714.258.428.200|C07.650.525.304|C16.131.850.525.304	Fibromatosis, Gingival	Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)	""	0	#FFFFFF
D005352	C14.907.137.372	Fibromuscular Dysplasia	An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.	""	0	#FFFFFF
D005354	C04.557.450.565.590.350|C04.557.450.795.350	Fibrosarcoma	A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	""	0	#FFFFFF
D005355	C23.550.355	Fibrosis	Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	""	0	#FFFFFF
D005356	C05.651.324|C05.799.321|C10.668.491.425	Fibromyalgia	A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)	""	0	#FFFFFF
D005357	C05.116.099.708.375	Fibrous Dysplasia of Bone	A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).	""	0	#FFFFFF
D005358	C05.116.099.708.375.372	Fibrous Dysplasia, Monostotic	FIBROUS DYSPLASIA OF BONE involving only one bone.	""	0	#FFFFFF
D005359	C05.116.099.708.375.381	Fibrous Dysplasia, Polyostotic	FIBROUS DYSPLASIA OF BONE affecting several bones. When melanotic pigmentation (CAFE-AU-LAIT SPOTS) and multiple endocrine hyperfunction are additionally associated it is referred to as Albright syndrome.	""	0	#FFFFFF
D005368	C01.610.335.508.700.750.361	Filariasis	Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.	""	0	#FFFFFF
D005383	C26.448.429	Finger Injuries	General or unspecified injuries involving the fingers.	""	0	#FFFFFF
D005393	C22.362	Fish Diseases	Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).	""	0	#FFFFFF
D005401	C06.405.469.860.101.430	Fissure in Ano	A painful linear tear at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal.	""	0	#FFFFFF
D005402	C23.300.575	Fistula	Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.	""	0	#FFFFFF
D005409	C26.891.315	Flail Chest	A complication of multiple RIB FRACTURES; RIB and STERNUM fractures, or thoracic surgery. A portion of the THORACIC WALL becomes isolated from the RIB CAGE and exhibits paradoxical respiration.	""	0	#FFFFFF
D005413	C05.330.488.655.250|C05.330.495.681.250|C05.660.585.512.380.813.250|C16.131.621.585.512.500.681.250	Flatfoot	Anomaly in which one or more of the arches of the feet are flat.	""	0	#FFFFFF
D005414	C23.888.821.360	Flatulence	Production or presence of gas in the gastrointestinal tract which may be expelled through the anus.	""	0	#FFFFFF
D005458	C25.723.380	Fluoride Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of FLUORIDE compounds.	""	0	#FFFFFF
D005483	C23.888.885.344	Flushing	A transient reddening of the face that may be due to fever, certain drugs, exertion, or stress.	""	0	#FFFFFF
D005489	C05.116.099.370.380|C16.131.077.350.424|C16.131.831.350.424|C16.320.322.186|C16.320.850.250.424|C17.800.804.350.424|C17.800.827.250.424	Focal Dermal Hypoplasia	A genetic skin disease characterized by hypoplasia of the dermis, herniations of fat, and hand anomalies. It is found exclusively in females and transmitted as an X-linked dominant trait.	""	0	#FFFFFF
D005490	C01.392	Focal Infection	An infection at a specific location that may spread to another region of the body.	""	0	#FFFFFF
D005491	C01.392.433|C07.793.348	Focal Infection, Dental	Secondary or systemic infections due to dissemination throughout the body of microorganisms whose primary focus of infection lies in the periodontal tissues.	""	0	#FFFFFF
D005494	C18.654.521.500.133.699.308	Folic Acid Deficiency	A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)	""	0	#FFFFFF
D005497	C04.182.300	Follicular Cyst	Cyst due to the occlusion of the duct of a follicle or small gland.	""	0	#FFFFFF
D005499	C17.800.329.500	Folliculitis	Inflammation of follicles, primarily hair follicles.	""	0	#FFFFFF
D005512	C20.543.480.370	Food Hypersensitivity	Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.	""	0	#FFFFFF
D005517	C25.723.415	Foodborne Diseases	Acute illnesses, usually affecting the GASTROINTESTINAL TRACT, brought on by consuming contaminated food or beverages. Most of these diseases are infectious, caused by a variety of bacteria, viruses, or parasites that can be foodborne. Sometimes the diseases are caused by harmful toxins from the microbes or other chemicals present in the food. Especially in the latter case, the condition is often called food poisoning.	""	0	#FFFFFF
D005530	C05.330	Foot Deformities	Alterations or deviations from normal shape or size which result in a disfigurement of the foot.	""	0	#FFFFFF
D005531	C05.330.488	Foot Deformities, Acquired	Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.	""	0	#FFFFFF
D005532	C05.330.495|C05.660.585.512.380|C16.131.621.585.512.500	Foot Deformities, Congenital	Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.	""	0	#FFFFFF
D005533	C17.800.321.125	Foot Dermatoses	Skin diseases of the foot, general or unspecified.	""	0	#FFFFFF
D005534	C05.360|C17.800.321	Foot Diseases	Anatomical and functional disorders affecting the foot.	""	0	#FFFFFF
D005535	C01.150.252.400.369|C22.394	Foot Rot	A disease of the horny parts and of the adjacent soft structures of the feet of cattle, swine, and sheep. It is usually caused by Corynebacterium pyogenes or Bacteroides nodosus (see DICHELOBACTER NODOSUS). It is also known as interdigital necrobacillosis. (From Black's Veterinary Dictionary, 18th ed)	""	0	#FFFFFF
D005536	C01.925.782.687.484|C22.380	Foot-and-Mouth Disease	A highly infectious disease caused by FOOT AND MOUTH DISEASE VIRUS that affects mammals of the ARTIODACTYLA order (CATTLE; SHEEP; GOATS; and PIGS) and is characterized by high fever followed by the appearance of blisters inside the mouth and on the feet.	""	0	#FFFFFF
D005543	C26.088.268	Forearm Injuries	Injuries to the part of the upper limb of the body between the wrist and elbow.	""	0	#FFFFFF
D005547	C26.392	Foreign Bodies	Inanimate objects that become enclosed in the body.	""	0	#FFFFFF
D005548	C26.392.500	Foreign-Body Migration	Migration of a foreign body from its original location to some other location in the body.	""	0	#FFFFFF
D005549	C23.550.470.251|C26.392.560	Foreign-Body Reaction	Chronic inflammation and granuloma formation around irritating foreign bodies.	""	0	#FFFFFF
D005585	C01.925.782.620.300|C22.131.450	Influenza in Birds	Infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY.	""	0	#FFFFFF
D005586	C01.925.256.743.366|C22.131.321	Fowlpox	A poxvirus infection of poultry and other birds characterized by the formation of wart-like nodules on the skin and diphtheritic necrotic masses (cankers) in the upper digestive and respiratory tracts.	""	0	#FFFFFF
D005588	C17.800.946.492.285	Fox-Fordyce Disease	Chronic pruritic disease, usually in women, characterized by small follicular papular eruptions in APOCRINE GLANDS areas. It is caused by obstruction and rupture of intraepidermal apocrine ducts.	""	0	#FFFFFF
D005596	C26.404.124	Fractures, Closed	Fractures in which the break in bone is not accompanied by an external wound.	""	0	#FFFFFF
D005597	C26.404.311	Fractures, Open	Fractures in which there is an external wound communicating with the break of the bone.	""	0	#FFFFFF
D005598	C26.404.374	Fractures, Spontaneous	Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)	""	0	#FFFFFF
D005599	C26.404.468	Fractures, Ununited	A fracture in which union fails to occur, the ends of the bone becoming rounded and eburnated, and a false joint occurs. (Stedman, 25th ed)	""	0	#FFFFFF
D005600	C10.597.606.360.455.500|C16.131.260.830.300|C16.320.180.830.300|C16.320.322.500.500|C16.320.400.525.500	Fragile X Syndrome	A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)	""	0	#FFFFFF
D005611	C12.050.351.875.253.795.124|C12.200.706.316.795.124|C12.800.316.795.124|C16.131.939.316.795.124|C19.391.119.795.124|C22.196.339	Freemartinism	"A condition occurring in the female offspring of dizygotic twins (TWIN, DIZYGOTIC) in a mixed-sex pregnancy, usually in CATTLE. Freemartinism can occur in other mammals. When placental fusion between the male and the female FETUSES permits the exchange of fetal cells and fetal hormones, TESTICULAR HORMONES from the male fetus can androgenize the female fetus producing a sterile XX/XY chimeric ""female""(CHIMERISM)."	""	0	#FFFFFF
D005621	C10.228.140.252.700.150|C10.228.854.787.200|C10.574.500.825.200|C16.320.400.780.200|C18.452.660.300	Friedreich Ataxia	An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)	""	0	#FFFFFF
D005627	C26.212.500|C26.417	Frostbite	Damage to tissues as the result of low environmental temperatures.	""	0	#FFFFFF
D005633	C16.320.565.202.251.271|C18.452.648.202.251.271	Fructose Intolerance	An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.	""	0	#FFFFFF
D005642	C11.204.236.438|C11.270.162.438|C16.320.290.162.410	Fuchs' Endothelial Dystrophy	Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.	""	0	#FFFFFF
D005645	C10.228.140.163.100.435.295|C16.320.565.189.435.295|C16.320.565.202.303|C16.320.565.595.554.295|C18.452.132.100.435.295|C18.452.648.189.435.295|C18.452.648.202.303|C18.452.648.595.554.295	Fucosidosis	An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an accumulation of fucose containing SPHINGOLIPIDS; GLYCOPROTEINS, and mucopolysaccharides (GLYCOSAMINOGLYCANS) in lysosomes. The infantile form (type I) features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA, with death occurring in the first decade of life. Juvenile fucosidosis (type II) is the more common variant and features a slowly progressive decline in neurologic function and angiokeratoma corporis diffusum. Type II survival may be through the fourth decade of life. (From Menkes, Textbook of Child Neurology, 5th ed, p87; Am J Med Genet 1991 Jan;38(1):111-31)	""	0	#FFFFFF
D005660	C05.116.099.386|C05.660.386|C16.131.621.386	Funnel Chest	A developmental anomaly in which the lower sternum is posteriorly dislocated and concavely deformed, resulting in a funnel-shaped thorax.	""	0	#FFFFFF
D005667	C01.150.252.410.868.951.270|C01.150.252.819.770.270|C01.800.720.770.270|C17.800.838.765.770.270|C22.362.224	Furunculosis	A persistent skin infection marked by the presence of furuncles, often chronic and recurrent. In humans, the causative agent is various species of STAPHYLOCOCCUS. In salmonid fish (SALMONIDS), the pathogen is AEROMONAS SALMONICIDA.	""	0	#FFFFFF
D005671	C07.650.800.370|C07.793.700.370|C16.131.850.800.370	Fused Teeth	Two teeth united during development by the union of their tooth germs; the teeth may be joined by the enamel of their crowns, by their root dentin, or by both.	""	0	#FFFFFF
D005674	C01.150.252.400.388.350	Fusobacterium Infections	Infections with bacteria of the genus FUSOBACTERIUM.	""	0	#FFFFFF
D005683	C23.888.821.414	Gagging	Contraction of the muscle of the PHARYNX caused by stimulation of sensory receptors on the SOFT PALATE, by psychic stimuli, or systemically by drugs.	""	0	#FFFFFF
D005687	C12.050.703.844.506.389|C17.800.090.937.439	Galactorrhea	Excessive or inappropriate LACTATION in females or males, and not necessarily related to PREGNANCY. Galactorrhea can occur either unilaterally or bilaterally, and be profuse or sparse. Its most common cause is HYPERPROLACTINEMIA.	""	0	#FFFFFF
D005693	C10.228.140.163.100.320|C16.320.565.189.320|C16.320.565.202.355|C18.452.132.100.320|C18.452.648.189.320|C18.452.648.202.355	Galactosemias	A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (PRIMARY OVARIAN INSUFFICIENCY); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)	""	0	#FFFFFF
D005705	C06.130.564	Gallbladder Diseases	Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.	""	0	#FFFFFF
D005706	C04.588.274.120.401|C06.130.320.401|C06.130.564.401|C06.301.120.401	Gallbladder Neoplasms	Tumors or cancer of the gallbladder.	""	0	#FFFFFF
D005729	C04.557.465.625.600.355|C04.557.470.670.355|C04.557.580.625.600.355	Ganglioneuroma	A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. The tumor may present clinically with HORNER SYNDROME or diarrhea due to ectopic production of vasoactive intestinal peptide. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p966)	""	0	#FFFFFF
D005733	C10.228.140.163.100.435.825.300|C16.320.565.189.435.825.300|C16.320.565.398.641.803.350|C16.320.565.595.554.825.300|C18.452.132.100.435.825.300|C18.452.584.563.641.803.350|C18.452.648.189.435.825.300|C18.452.648.398.641.803.350|C18.452.648.595.554.825.300	Gangliosidoses	A group of autosomal recessive lysosomal storage disorders marked by the accumulation of GANGLIOSIDES. They are caused by impaired enzymes or defective cofactors required for normal ganglioside degradation in the LYSOSOMES. Gangliosidoses are classified by the specific ganglioside accumulated in the defective degradation pathway.	""	0	#FFFFFF
D005734	C23.550.717.427	Gangrene	Death and putrefaction of tissue usually due to a loss of blood supply.	""	0	#FFFFFF
D005736	C04.557.470.035.215.100.500|C04.588.274.476.411.307.089.393|C04.700.100.392|C06.301.371.411.307.090.500|C06.405.249.411.307.090.500|C06.405.469.158.356.090.500|C06.405.469.491.307.090.500|C06.405.469.578.249.393|C16.131.077.393|C16.320.700.100.393	Gardner Syndrome	A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.	""	0	#FFFFFF
D005738	C01.150.252.410.222.440	Gas Gangrene	A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.	""	0	#FFFFFF
D005739	C25.723.455	Gas Poisoning	Poisoning that results from exposure to gases such as CARBON MONOXIDE; NOBLE GASES; OXYGEN; or NATURAL GAS.	""	0	#FFFFFF
D005747	C06.267.375|C23.300.575.185.375	Gastric Fistula	Abnormal passage communicating with the STOMACH.	""	0	#FFFFFF
D005756	C06.405.205.697|C06.405.748.398	Gastritis	Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.	""	0	#FFFFFF
D005757	C06.405.205.697.394|C06.405.748.398.394	Gastritis, Atrophic	GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.	""	0	#FFFFFF
D005758	C06.405.205.697.410|C06.405.748.398.410	Gastritis, Hypertrophic	GASTRITIS with HYPERTROPHY of the GASTRIC MUCOSA. It is characterized by giant gastric folds, diminished acid secretion, excessive MUCUS secretion, and HYPOPROTEINEMIA. Symptoms include VOMITING; DIARRHEA; and WEIGHT LOSS.	""	0	#FFFFFF
D005759	C06.405.205	Gastroenteritis	INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.	""	0	#FFFFFF
D005761	C01.925.782.600.550.200.400|C22.905.469	Gastroenteritis, Transmissible, of Swine	A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.	""	0	#FFFFFF
D005764	C06.405.117.119.500.484	Gastroesophageal Reflux	Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.	""	0	#FFFFFF
D005767	C06.405	Gastrointestinal Diseases	Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.	""	0	#FFFFFF
D005770	C04.588.274.476|C06.301.371|C06.405.249	Gastrointestinal Neoplasms	Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.	""	0	#FFFFFF
D005776	C10.228.140.163.100.435.825.400|C16.320.565.189.435.825.400|C16.320.565.398.641.803.441|C16.320.565.595.554.825.400|C18.452.132.100.435.825.400|C18.452.584.563.641.803.441|C18.452.648.189.435.825.400|C18.452.648.398.641.803.441|C18.452.648.595.554.825.400	Gaucher Disease	An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.	""	0	#FFFFFF
D005831	C12.050.351.500|C12.100.250	Genital Diseases, Female	Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).	""	0	#FFFFFF
D005832	C12.100.500|C12.200.294	Genital Diseases, Male	Pathological processes involving the male reproductive tract (GENITALIA, MALE).	""	0	#FFFFFF
D005833	C04.588.945.418|C12.050.351.937.418|C12.900.418	Genital Neoplasms, Female	Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).	""	0	#FFFFFF
D005834	C04.588.945.440|C12.100.500.260|C12.200.294.260|C12.200.758.409|C12.900.619	Genital Neoplasms, Male	Tumor or cancer of the MALE GENITALIA.	""	0	#FFFFFF
D005847	C01.150.703.392	Geotrichosis	Infection due to the fungus Geotrichum.	""	0	#FFFFFF
D005862	C10.597.606.762.100.300|C23.888.592.604.764.100.300	Gerstmann Syndrome	A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, DYSCALCULIA, and right-left disorientation. The syndrome may be developmental or acquired. Acquired Gerstmann syndrome is associated with lesions in the dominant (usually left) PARIETAL LOBE which involve the angular gyrus or subjacent white matter. (From Adams et al., Principles of Neurology, 6th ed, p457)	""	0	#FFFFFF
D005870	C04.557.450.565.380	Giant Cell Tumors	Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.	""	0	#FFFFFF
D005871	C15.604.515.245|C20.683.515.250	Castleman Disease	Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.	""	0	#FFFFFF
D005873	C01.610.432.481|C01.610.752.400|C06.405.469.452.481	Giardiasis	An infection of the SMALL INTESTINE caused by the flagellated protozoan GIARDIA. It is spread via contaminated food and water and by direct person-to-person contact.	""	0	#FFFFFF
D005877	C05.116.099.492|C05.116.132.479|C19.700.355.528	Gigantism	The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.	""	0	#FFFFFF
D005878	C16.320.565.300.528|C18.452.648.300.528	Gilbert Disease	A benign familial disorder, transmitted as an autosomal dominant trait. It is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level.	""	0	#FFFFFF
D005879	C10.228.140.079.898|C10.228.662.825.800|C10.574.500.850|C16.320.400.820	Tourette Syndrome	A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)	""	0	#FFFFFF
D005882	C07.465.714.258	Gingival Diseases	Diseases involving the GINGIVA.	""	0	#FFFFFF
D005884	C07.465.625.446|C07.465.714.258.250|C23.550.414.922.500	Gingival Hemorrhage	The flowing of blood from the marginal gingival area, particularly the sulcus, seen in such conditions as GINGIVITIS, marginal PERIODONTITIS, injury, and ASCORBIC ACID DEFICIENCY.	""	0	#FFFFFF
D005885	C07.465.714.258.428.250	Gingival Hyperplasia	Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)	""	0	#FFFFFF
D005886	C07.465.714.258.428.260	Gingival Hypertrophy	Abnormal enlargement or overgrowth of the gingivae brought about by enlargement of existing cells.	""	0	#FFFFFF
D005887	C04.588.443.591.402|C07.465.530.402|C07.465.714.258.409	Gingival Neoplasms	New abnormal growth of tissue in the GINGIVA.	""	0	#FFFFFF
D005888	C01.408.360|C07.465.714.258.480.360	Gingival Pocket	An abnormal extension of a gingival sulcus not accompanied by the apical migration of the epithelial attachment.	""	0	#FFFFFF
D005889	C07.465.714.258.447|C07.465.714.354.625	Gingival Recession	Exposure of the root surface when the edge of the gum (GINGIVA) moves apically away from the crown of the tooth. This is common with advancing age, vigorous tooth brushing, diseases, or tissue loss of the gingiva, the PERIODONTAL LIGAMENT and the supporting bone (ALVEOLAR PROCESS).	""	0	#FFFFFF
D005891	C01.408|C07.465.714.258.480	Gingivitis	Inflammation of gum tissue (GINGIVA) without loss of connective tissue.	""	0	#FFFFFF
D005892	C01.150.252.400.388.350.350|C01.408.446|C07.465.714.258.480.446	Gingivitis, Necrotizing Ulcerative	An acute or chronic GINGIVITIS characterized by redness and swelling, NECROSIS extending from the interdental papillae along the gingival margins, PAIN; HEMORRHAGE, necrotic odor, and often a pseudomembrane. The condition may extend to the ORAL MUCOSA; TONGUE; PALATE; or PHARYNX. The etiology is somewhat unclear, but may involve a complex of FUSOBACTERIUM NUCLEATUM along with spirochetes BORRELIA or TREPONEMA.	""	0	#FFFFFF
D005896	C01.150.252.400.170.400|C22.488.409	Glanders	A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.	""	0	#FFFFFF
D005901	C11.525.381	Glaucoma	An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)	""	0	#FFFFFF
D005902	C11.525.381.407	Glaucoma, Open-Angle	Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.	""	0	#FFFFFF
D005909	C04.557.465.625.600.380.080.335|C04.557.470.670.380.080.335|C04.557.580.625.600.380.080.335	Glioblastoma	A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	""	0	#FFFFFF
D005910	C04.557.465.625.600.380|C04.557.470.670.380|C04.557.580.625.600.380	Glioma	Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	""	0	#FFFFFF
D005911	C23.550.369	Gliosis	The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.	""	0	#FFFFFF
D005918	C04.557.645.350	Glomus Tumor	A blue-red, extremely painful vascular neoplasm involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter (From Stedman, 27th ed). CHEMODECTOMA, a tumor of NEURAL CREST origin, is also sometimes called a glomus tumor.	""	0	#FFFFFF
D005921	C12.050.351.968.419.570.363|C12.200.777.419.570.363|C12.950.419.570.363	Glomerulonephritis	Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.	""	0	#FFFFFF
D005922	C12.050.351.968.419.570.363.608|C12.200.777.419.570.363.608|C12.950.419.570.363.608|C20.111.525	Glomerulonephritis, IGA	A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.	""	0	#FFFFFF
D005923	C12.050.351.968.419.570.363.640|C12.200.777.419.570.363.660|C12.950.419.570.363.640	Glomerulosclerosis, Focal Segmental	A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.	""	0	#FFFFFF
D005925	C04.557.465.625.650.700.705.340|C04.557.580.625.650.700.705.340	Glomus Jugulare Tumor	A paraganglioma involving the glomus jugulare, a microscopic collection of chemoreceptor tissue in the adventitia of the bulb of the jugular vein. It may cause paralysis of the vocal cords, attacks of dizziness, blackouts, and nystagmus. It is not resectable but radiation therapy is effective. It regresses slowly, but permanent control is regularly achieved. (From Dorland, 27th ed; Stedman, 25th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1603-4)	""	0	#FFFFFF
D005926	C07.465.910.280|C23.888.592.612.414	Glossalgia	Painful sensations in the tongue, including a sensation of burning.	""	0	#FFFFFF
D005928	C07.465.910.363	Glossitis	Inflammation of the tongue.	""	0	#FFFFFF
D005929	C07.465.910.363.447	Glossitis, Benign Migratory	An idiopathic disorder of the tongue characterized by the loss of filiform papillae leaving reddened areas of circinate macules bound by a white band. The lesions heal, then others erupt.	""	0	#FFFFFF
D005935	C04.557.470.200.025.290.750|C04.588.274.761.500.249|C04.588.322.475.500.249|C06.301.761.500.249|C06.689.667.500.249|C19.344.421.500.249	Glucagonoma	An almost always malignant GLUCAGON-secreting tumor derived from the PANCREATIC ALPHA CELLS. It is characterized by a distinctive migratory ERYTHEMA; WEIGHT LOSS; STOMATITIS; GLOSSITIS; DIABETES MELLITUS; hypoaminoacidemia; and normochromic normocytic ANEMIA.	""	0	#FFFFFF
D005953	C16.320.565.202.449.448|C18.452.648.202.449.448	Glycogen Storage Disease Type I	An autosomal recessive disease in which gene expression of glucose-6-phosphatase is absent, resulting in hypoglycemia due to lack of glucose production. Accumulation of glycogen in liver and kidney leads to organomegaly, particularly massive hepatomegaly. Increased concentrations of lactic acid and hyperlipidemia appear in the plasma. Clinical gout often appears in early childhood.	""	0	#FFFFFF
D005955	C15.378.071.141.150.480|C16.320.070.480|C16.320.565.202.402|C18.452.648.202.402	Glucosephosphate Dehydrogenase Deficiency	A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.	""	0	#FFFFFF
D006008	C16.320.565.202.449|C18.452.648.202.449	Glycogen Storage Disease	A group of inherited metabolic disorders involving the enzymes responsible for the synthesis and degradation of glycogen. In some patients, prominent liver involvement is presented. In others, more generalized storage of glycogen occurs, sometimes with prominent cardiac involvement.	""	0	#FFFFFF
D006009	C10.228.140.163.100.435.340|C16.320.565.189.435.340|C16.320.565.202.449.500|C16.320.565.595.554.340|C18.452.132.100.435.340|C18.452.648.189.435.340|C18.452.648.202.449.500|C18.452.648.595.554.340	Glycogen Storage Disease Type II	An autosomal recessively inherited glycogen storage disease caused by GLUCAN 1,4-ALPHA-GLUCOSIDASE deficiency. Large amounts of GLYCOGEN accumulate in the LYSOSOMES of skeletal muscle (MUSCLE, SKELETAL); HEART; LIVER; SPINAL CORD; and BRAIN. Three forms have been described: infantile, childhood, and adult. The infantile form is fatal in infancy and presents with hypotonia and a hypertrophic cardiomyopathy (CARDIOMYOPATHY, HYPERTROPHIC). The childhood form usually presents in the second year of life with proximal weakness and respiratory symptoms. The adult form consists of a slowly progressive proximal myopathy. (From Muscle Nerve 1995;3:S61-9; Menkes, Textbook of Child Neurology, 5th ed, pp73-4)	""	0	#FFFFFF
D006010	C16.320.565.202.449.520|C18.452.648.202.449.520	Glycogen Storage Disease Type III	An autosomal recessive metabolic disorder due to deficient expression of amylo-1,6-glucosidase (one part of the glycogen debranching enzyme system). The clinical course of the disease is similar to that of glycogen storage disease type I, but milder. Massive hepatomegaly, which is present in young children, diminishes and occasionally disappears with age. Levels of glycogen with short outer branches are elevated in muscle, liver, and erythrocytes. Six subgroups have been identified, with subgroups Type IIIa and Type IIIb being the most prevalent.	""	0	#FFFFFF
D006011	C16.320.565.202.449.540|C18.452.648.202.449.540	Glycogen Storage Disease Type IV	An autosomal recessive metabolic disorder due to a deficiency in expression of glycogen branching enzyme 1 (alpha-1,4-glucan-6-alpha-glucosyltransferase), resulting in an accumulation of abnormal GLYCOGEN with long outer branches. Clinical features are MUSCLE HYPOTONIA and CIRRHOSIS. Death from liver disease usually occurs before age 2.	""	0	#FFFFFF
D006012	C16.320.565.202.449.560|C18.452.648.202.449.560	Glycogen Storage Disease Type V	Glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise.	""	0	#FFFFFF
D006013	C16.320.565.202.449.580|C18.452.648.202.449.580	Glycogen Storage Disease Type VI	A hepatic GLYCOGEN STORAGE DISEASE in which there is an apparent deficiency of hepatic phosphorylase (GLYCOGEN PHOSPHORYLASE, LIVER FORM) activity.	""	0	#FFFFFF
D006014	C05.651.534.500.149|C10.668.491.175.500.112|C16.320.565.202.449.600|C16.320.577.149|C18.452.648.202.449.600	Glycogen Storage Disease Type VII	An autosomal recessive glycogen storage disease in which there is deficient expression of 6-phosphofructose 1-kinase in muscle (PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE) resulting in abnormal deposition of glycogen in muscle tissue. These patients have severe congenital muscular dystrophy and are exercise intolerant.	""	0	#FFFFFF
D006015	C16.320.322.217|C16.320.565.202.449.620|C18.452.648.202.449.620	Glycogen Storage Disease Type VIII	An x-linked recessive hepatic glycogen storage disease resulting from lack of expression of phosphorylase-b-kinase activity. Symptoms are relatively mild; hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase are present. Liver shrinkage occurs in response to glucagon.	""	0	#FFFFFF
D006029	C12.050.351.968.934.363|C12.200.777.934.363|C12.950.934.363|C18.452.394.937	Glycosuria	The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).	""	0	#FFFFFF
D006030	C12.050.351.968.419.815.532|C12.050.351.968.934.363.450|C12.200.777.419.815.532|C12.200.777.934.363.450|C12.950.419.815.532|C12.950.934.363.450|C16.320.831.532|C18.452.394.937.450	Glycosuria, Renal	An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of glucose can reach beyond 50 g/day. It is attributed to the mutations in the SODIUM-GLUCOSE TRANSPORTER 2 encoded by the SLC5A2 gene.	""	0	#FFFFFF
D006042	C19.874.283	Goiter	Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).	""	0	#FFFFFF
D006043	C19.874.283.300	Goiter, Endemic	A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine.	""	0	#FFFFFF
D006044	C19.874.283.501	Goiter, Nodular	An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.	""	0	#FFFFFF
D006045	C19.874.283.601	Goiter, Substernal	An enlarged THYROID GLAND with at least 50% of the gland situated behind the STERNUM. It is an unusual presentation of an intrathoracic goiter. Substernal goiters frequently cause compression on the TRACHEA leading to deviation, narrowing, and respiratory symptoms.	""	0	#FFFFFF
D006053	C05.116.099.370.231.576.410|C05.660.207.231.576.410|C16.131.621.207.231.576.410	Goldenhar Syndrome	Mandibulofacial dysostosis with congenital eyelid dermoids.	""	0	#FFFFFF
D006058	C19.391	Gonadal Disorders	Pathological processes of the OVARIES or the TESTES.	""	0	#FFFFFF
D006059	C12.050.351.875.253.309|C12.200.706.316.309|C12.800.316.309|C16.131.939.316.309|C19.391.119.309	Gonadal Dysgenesis	A number of syndromes with defective gonadal developments such as streak GONADS and dysgenetic testes or ovaries. The spectrum of gonadal and sexual abnormalities is reflected in their varied sex chromosome (SEX CHROMOSOMES) constitution as shown by the karyotypes of 45,X monosomy (TURNER SYNDROME); 46,XX (GONADAL DYSGENESIS, 46XX); 46,XY (GONADAL DYSGENESIS, 46,XY); and sex chromosome MOSAICISM; (GONADAL DYSGENESIS, MIXED). Their phenotypes range from female, through ambiguous, to male. This concept includes gonadal agenesis.	""	0	#FFFFFF
D006060	C12.050.351.875.253.309.391|C12.050.351.875.253.795.249|C12.200.706.316.309.391|C12.200.706.316.795.249|C12.800.316.309.391|C12.800.316.795.249|C16.131.260.830.835.249|C16.131.939.316.309.391|C16.131.939.316.795.249|C16.320.180.830.835.249|C19.391.119.309.391|C19.391.119.795.249	Gonadal Dysgenesis, Mixed	A type of defective gonadal development in patients with a wide spectrum of chromosomal mosaic variants. Their karyotypes are of partial sex chromosome monosomy resulting from an absence or an abnormal second sex chromosome (X or Y). Karyotypes include 45,X/46,XX; 45,X/46,XX/47,XXX; 46,XXp-; 45,X/46,XY; 45,X/47,XYY; 46,XYpi; etc. The spectrum of phenotypes may range from phenotypic female to phenotypic male including variations in gonads and internal and external genitalia, depending on the ratio in each gonad of 45,X primordial germ cells to those with normal 46,XX or 46,XY constitution.	""	0	#FFFFFF
D006061	C12.050.351.875.253.096.687|C12.050.351.875.253.309.388|C12.200.706.316.096.687|C12.200.706.316.309.388|C12.800.316.096.687|C12.800.316.309.388|C16.131.939.316.096.687|C16.131.939.316.309.388|C19.391.119.096.687|C19.391.119.309.388	Gonadal Dysgenesis, 46,XY	Defects in the SEX DETERMINATION PROCESS in 46, XY individuals that result in abnormal gonadal development and deficiencies in TESTOSTERONE and subsequently ANTIMULLERIAN HORMONE or other factors required for normal male sex development. This leads to the development of female phenotypes (male to female sex reversal), normal to tall stature, and bilateral streak or dysgenic gonads which are susceptible to GONADAL TISSUE NEOPLASMS. An XY gonadal dysgenesis is associated with structural abnormalities on the Y CHROMOSOME, a mutation in the GENE, SRY, or a mutation in other autosomal genes that are involved in sex determination.	""	0	#FFFFFF
D006069	C01.150.252.400.625.275|C01.150.252.734.401|C01.221.812.281.401|C01.778.281.401|C12.100.937.281.401	Gonorrhea	Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.	""	0	#FFFFFF
D006073	C05.550.114.423|C05.550.354.500|C05.799.414|C16.320.565.798.368|C18.452.648.798.368	Gout	Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.	""	0	#FFFFFF
D006083	C23.550.767.400	Graft Occlusion, Vascular	Obstruction of flow in biological or prosthetic vascular grafts.	""	0	#FFFFFF
D006086	C20.452	Graft vs Host Disease	The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.	""	0	#FFFFFF
D006099	C15.604.515.292|C23.550.382	Granuloma	A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.	""	0	#FFFFFF
D006100	C01.150.252.400.310.417|C01.150.252.734.451|C01.150.252.819.360|C01.221.812.281.451|C01.778.281.451|C01.800.720.360|C12.100.937.281.451|C17.800.838.765.360	Granuloma Inguinale	Anogenital ulcers caused by Calymmatobacterium granulomatis as distinguished from lymphogranuloma inguinale (see LYMPHOGRANULOMA VENEREUM) caused by CHLAMYDIA TRACHOMATIS. Diagnosis is made by demonstration of typical intracellular Donovan bodies in crushed-tissue smears.	""	0	#FFFFFF
D006101	C05.500.368|C07.320.391|C07.465.714.258.557|C23.550.382.468	Granuloma, Giant Cell	A non-neoplastic inflammatory lesion, usually of the jaw or gingiva, containing large, multinucleated cells. It includes reparative giant cell granuloma. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis); central refers to the jaw.	""	0	#FFFFFF
D006102	C08.280.400|C08.360.232|C08.618.846.414|C09.400.232|C23.550.382.968.500	Granuloma, Laryngeal	A tumor-like nodule or mass of inflammatory granulation tissue projecting into the lumen of the LARYNX.	""	0	#FFFFFF
D006103	C08.460.393|C09.603.393	Granuloma, Lethal Midline	A condition that is characterized by inflammation, ulceration, and perforation of the nose and the PALATE with progressive destruction of midline facial structures. This syndrome can be manifested in several diseases including the nasal type of EXTRANODAL NK-T-CELL LYMPHOMA and GRANULOMATOSIS WITH POLYANGIITIS.	""	0	#FFFFFF
D006104	C23.550.382.875	Granuloma, Plasma Cell	A slow-growing benign pseudotumor in which plasma cells greatly outnumber the inflammatory cells.	""	0	#FFFFFF
D006105	C15.378.553.774.535|C16.320.322.233|C20.673.774.535|C23.550.291.500.423	Granulomatous Disease, Chronic	A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.	""	0	#FFFFFF
D006106	C04.557.475.750.656|C04.588.322.455.398|C12.050.351.500.056.630.705.398|C12.050.351.937.418.685.398|C12.100.250.056.630.705.398|C12.900.418.685.398|C19.344.410.398|C19.391.630.705.398	Granulosa Cell Tumor	A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.	""	0	#FFFFFF
D006111	C11.675.349.500|C19.874.283.605|C19.874.397.370|C20.111.555	Graves Disease	A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).	""	0	#FFFFFF
D006130	C23.550.393	Growth Disorders	Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.	""	0	#FFFFFF
D006175	C12.050.351.500.320|C12.100.250.320	Gynatresia	Absence of a normal opening in the lumen of the female genital tract, from the FALLOPIAN TUBES to the VAGINA. This anomaly may be congenital or acquired due to injuries, diseases, or TISSUE ADHESIONS.	""	0	#FFFFFF
D006177	C17.800.090.875	Gynecomastia	Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.	""	0	#FFFFFF
D006188	C01.610.335.508.700.775.825.400	Haemonchiasis	Infection with nematodes of the genus HAEMONCHUS, characterized by digestive abnormalities and anemia similar to that from hookworm infestation.	""	0	#FFFFFF
D006192	C01.150.252.400.700.433	Haemophilus Infections	Infections with bacteria of the genus HAEMOPHILUS.	""	0	#FFFFFF
D006201	C17.800.329	Hair Diseases	Diseases affecting the orderly growth and persistence of hair.	""	0	#FFFFFF
D006209	C23.888.821.475	Halitosis	An offensive, foul breath odor resulting from a variety of causes such as poor oral hygiene, dental or oral infections, or the ingestion of certain foods.	""	0	#FFFFFF
D006210	C05.116.099.370.231.427|C05.660.207.231.427|C16.131.621.207.231.427	Hallermann's Syndrome	An oculomandibulofacial syndrome principally characterized by dyscephaly (usually brachycephaly), parrot nose, mandibular hypoplasia, proportionate nanism, hypotrichosis, bilateral congenital cataracts, and microphthalmia. (Dorland, 27th ed)	""	0	#FFFFFF
D006211	C10.228.140.079.800|C10.228.140.744.320|C10.228.662.575|C10.574.500.700|C16.320.400.650	Pantothenate Kinase-Associated Neurodegeneration	A rare autosomal recessive degenerative disorder which usually presents in late childhood or adolescence. Clinical manifestations include progressive MUSCLE SPASTICITY; hyperreflexia; MUSCLE RIGIDITY; DYSTONIA; DYSARTHRIA; and intellectual deterioration which progresses to severe dementia over several years. (From Adams et al., Principles of Neurology, 6th ed, p972; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp972-929)	""	0	#FFFFFF
D006212	C10.597.606.762.300|C23.888.592.604.764.300	Hallucinations	Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.	""	0	#FFFFFF
D006215	C05.330.610	Hallux Valgus	Lateral displacement of the great toe (HALLUX), producing deformity of the first METATARSOPHALANGEAL JOINT with callous, bursa, or BUNION formation over the bony prominence.	""	0	#FFFFFF
D006222	C04.445	Hamartoma	A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area.	""	0	#FFFFFF
D006223	C04.445.435|C04.651.435|C04.700.435|C16.320.700.435	Hamartoma Syndrome, Multiple	A hereditary disease characterized by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Facial trichilemmomas and papillomatous papules of the oral mucosa are the most characteristic lesions. Individuals with this syndrome have a high risk of BREAST CANCER; THYROID CANCER; and ENDOMETRIAL CANCER. This syndrome is associated with mutations in the gene for PTEN PHOSPHATASE.	""	0	#FFFFFF
D006226	C05.390	Hand Deformities	Alterations or deviations from normal shape or size which result in a disfigurement of the hand.	""	0	#FFFFFF
D006227	C05.390.110	Hand Deformities, Acquired	Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.	""	0	#FFFFFF
D006228	C05.390.408|C05.660.585.988.425|C16.131.621.585.988.500	Hand Deformities, Congenital	Alterations or deviations from normal shape or size which result in a disfigurement of the hand occurring at or before birth.	""	0	#FFFFFF
D006229	C17.800.338	Hand Dermatoses	Skin diseases involving the HANDS.	""	0	#FFFFFF
D006230	C26.448	Hand Injuries	General or unspecified injuries to the hand.	""	0	#FFFFFF
D006232	C01.925.782.687.359.213.331	Hand, Foot and Mouth Disease	A mild, highly infectious viral disease of children, characterized by vesicular lesions in the mouth and on the hands and feet. It is caused by coxsackieviruses A.	""	0	#FFFFFF
D006250	C10.228.140.163.100.355|C12.050.351.968.419.815.885.625|C12.200.777.419.815.885.457|C12.950.419.815.885.625|C16.320.565.151.355|C16.320.565.189.355|C16.320.831.885.457|C18.452.132.100.355|C18.452.648.151.355|C18.452.648.189.355	Hartnup Disease	An autosomal recessive disorder due to defective absorption of NEUTRAL AMINO ACIDS by both the intestine and the PROXIMAL RENAL TUBULES. The abnormal urinary loss of TRYPTOPHAN, a precursor of NIACIN, leads to a NICOTINAMIDE deficiency, PELLAGRA-like light-sensitive rash, CEREBELLAR ATAXIA, emotional instability, and aminoaciduria. Mutations involve the neurotransmitter transporter gene SLC6A19.	""	0	#FFFFFF
D006255	C08.460.799.315.750|C08.674.453.750|C09.603.799.315.750|C20.543.480.680.443.750	Rhinitis, Allergic, Seasonal	Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.	""	0	#FFFFFF
D006258	C04.588.443	Head and Neck Neoplasms	Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	""	0	#FFFFFF
D006259	C10.900.300|C26.915.300	Craniocerebral Trauma	Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.	""	0	#FFFFFF
D006261	C23.888.592.612.441	Headache	The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.	""	0	#FFFFFF
D006311	C09.218.458|C10.597.751.418|C23.888.592.763.393	Hearing Disorders	Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices, including the sensorineural pathways.	""	0	#FFFFFF
D006312	C09.218.458.341.374|C10.597.751.418.341.374|C23.888.592.763.393.341.374	Hearing Loss, Bilateral	Partial hearing loss in both ears.	""	0	#FFFFFF
D006313	C09.218.458.341.887.432|C09.218.807.186.432|C10.228.140.068.432|C10.597.751.418.341.887.432|C23.888.592.763.393.341.887.432	Hearing Loss, Central	Hearing loss due to disease of the AUDITORY PATHWAYS (in the CENTRAL NERVOUS SYSTEM) which originate in the COCHLEAR NUCLEI of the PONS and then ascend bilaterally to the MIDBRAIN, the THALAMUS, and then the AUDITORY CORTEX in the TEMPORAL LOBE. Bilateral lesions of the auditory pathways are usually required to cause central hearing loss. Cortical deafness refers to loss of hearing due to bilateral auditory cortex lesions. Unilateral BRAIN STEM lesions involving the cochlear nuclei may result in unilateral hearing loss.	""	0	#FFFFFF
D006314	C09.218.458.341.562|C10.597.751.418.341.562|C23.888.592.763.393.341.562	Hearing Loss, Conductive	Hearing loss due to interference with the mechanical reception or amplification of sound to the COCHLEA. The interference is in the outer or middle ear involving the EAR CANAL; TYMPANIC MEMBRANE; or EAR OSSICLES.	""	0	#FFFFFF
D006315	C09.218.458.341.750|C10.597.751.418.341.750|C23.888.592.763.393.341.750	Hearing Loss, Functional	Hearing loss without a physical basis. Often observed in patients with psychological or behavioral disorders.	""	0	#FFFFFF
D006316	C09.218.458.341.812|C10.597.751.418.341.812|C23.888.592.763.393.341.812	Hearing Loss, High-Frequency	Hearing loss in frequencies above 1000 hertz.	""	0	#FFFFFF
D006317	C09.218.458.341.887.460|C10.597.751.418.341.887.460|C23.888.592.763.393.341.887.460	Hearing Loss, Noise-Induced	Hearing loss due to exposure to explosive loud noise or chronic exposure to sound level greater than 85 dB. The hearing loss is often in the frequency range 4000-6000 hertz.	""	0	#FFFFFF
D006319	C09.218.458.341.887|C10.597.751.418.341.887|C23.888.592.763.393.341.887	Hearing Loss, Sensorineural	Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.	""	0	#FFFFFF
D006322	C14.280.358|C14.907.055.608	Heart Aneurysm	A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.	""	0	#FFFFFF
D006323	C14.280.383	Heart Arrest	Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.	""	0	#FFFFFF
D006327	C14.280.067.558|C14.280.123.500|C23.550.073.425	Heart Block	Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.	""	0	#FFFFFF
D006330	C14.240.400|C14.280.400|C16.131.240.400	Heart Defects, Congenital	Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.	""	0	#FFFFFF
D006331	C14.280	Heart Diseases	Pathological conditions involving the HEART including its structural and functional abnormalities.	""	0	#FFFFFF
D006332	C14.280.195|C23.300.775.250	Cardiomegaly	Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.	""	0	#FFFFFF
D006333	C14.280.434	Heart Failure	A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.	""	0	#FFFFFF
D006335	C26.891.375	Heart Injuries	General or unspecified injuries to the heart.	""	0	#FFFFFF
D006337	C23.888.447	Heart Murmurs	Heart sounds caused by vibrations resulting from the flow of blood through the heart. Heart murmurs can be examined by HEART AUSCULTATION, and analyzed by their intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc).	""	0	#FFFFFF
D006338	C04.588.894.309|C14.280.459	Heart Neoplasms	Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.	""	0	#FFFFFF
D006341	C14.280.470	Heart Rupture	Disease-related laceration or tearing of tissues of the heart, including the free-wall MYOCARDIUM; HEART SEPTUM; PAPILLARY MUSCLES; CHORDAE TENDINEAE; and any of the HEART VALVES. Pathological rupture usually results from myocardial infarction (HEART RUPTURE, POST-INFARCTION).	""	0	#FFFFFF
D006342	C14.280.470.475	Heart Rupture, Post-Infarction	Laceration or tearing of cardiac tissues appearing after MYOCARDIAL INFARCTION.	""	0	#FFFFFF
D006343	C14.240.400.560|C14.280.400.560|C16.131.240.400.560	Heart Septal Defects	Abnormalities in any part of the HEART SEPTUM resulting in abnormal communication between the left and the right chambers of the heart. The abnormal blood flow inside the heart may be caused by defects in the ATRIAL SEPTUM, the VENTRICULAR SEPTUM, or both.	""	0	#FFFFFF
D006344	C14.240.400.560.375|C14.280.400.560.375|C16.131.240.400.560.375	Heart Septal Defects, Atrial	Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.	""	0	#FFFFFF
D006345	C14.240.400.560.540|C14.280.400.560.540|C16.131.240.400.560.540	Heart Septal Defects, Ventricular	Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.	""	0	#FFFFFF
D006349	C14.280.484	Heart Valve Diseases	Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).	""	0	#FFFFFF
D006356	C23.888.821.525	Heartburn	Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.	""	0	#FFFFFF
D006357	C01.150.252.400.054.750.500|C01.150.252.400.285.500|C01.920.930.300.500|C22.434	Heartwater Disease	A tick-borne septicemic disease of domestic and wild ruminants caused by EHRLICHIA RUMINANTIUM.	""	0	#FFFFFF
D006359	C26.522.250	Heat Exhaustion	A clinical syndrome caused by heat stress, such as over-exertion in a hot environment or excessive exposure to sun. It is characterized by SWEATING, water (volume) depletion, salt depletion, cool clammy skin, NAUSEA, and HEADACHE.	""	0	#FFFFFF
D006362	C15.378.147.780.490|C15.604.515.435|C20.683.780.490	Heavy Chain Disease	A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.	""	0	#FFFFFF
D006373	C01.610.335	Helminthiasis	Infestation with parasitic worms of the helminth class.	""	0	#FFFFFF
D006374	C01.610.335.349|C01.610.701.377|C22.674.377	Helminthiasis, Animal	Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.	""	0	#FFFFFF
D006390	C04.557.645.375.370	Hemangioendothelioma	A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)	""	0	#FFFFFF
D006391	C04.557.645.375	Hemangioma	A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)	""	0	#FFFFFF
D006392	C04.557.645.375.385|C14.907.454.385|C15.378.463.515.385	Hemangioma, Cavernous	A vascular anomaly that is a collection of tortuous BLOOD VESSELS and connective tissue. This tumor-like mass with the large vascular space is filled with blood and usually appears as a strawberry-like lesion in the subcutaneous areas of the face, extremities, or other regions of the body including the central nervous system.	""	0	#FFFFFF
D006393	C04.557.645.380	Hemangiopericytoma	A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)	""	0	#FFFFFF
D006394	C04.557.450.795.390|C04.557.645.390	Hemangiosarcoma	A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)	""	0	#FFFFFF
D006395	C05.550.459|C23.550.414.794	Hemarthrosis	Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.	""	0	#FFFFFF
D006396	C06.405.227.400|C23.550.414.788.400|C23.888.821.937.019	Hematemesis	"Vomiting of blood that is either fresh bright red, or older ""coffee-ground"" in character. It generally indicates bleeding of the UPPER GASTROINTESTINAL TRACT."	""	0	#FFFFFF
D006398	C12.100.500.287|C12.200.294.287|C23.550.414.817	Hematocele	Hemorrhage into a canal or cavity of the body, such as the space covered by the serous membrane (tunica vaginalis) around the TESTIS leading to testicular hematocele or scrotal hematocele.	""	0	#FFFFFF
D006399	C12.050.351.500.894.300|C12.100.250.894.300	Hematocolpos	A blood-filled VAGINA that is obstructed.	""	0	#FFFFFF
D006402	C15.378	Hematologic Diseases	Disorders of the blood and blood forming tissues.	""	0	#FFFFFF
D006406	C23.550.414.838	Hematoma	A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.	""	0	#FFFFFF
D006407	C10.228.140.300.535.450.300|C10.900.300.837.300|C14.907.253.573.400.400|C23.550.414.838.349|C23.550.414.913.400|C26.915.300.490.400	Hematoma, Epidural, Cranial	Accumulation of blood in the EPIDURAL SPACE between the SKULL and the DURA MATER, often as a result of bleeding from the MENINGEAL ARTERIES associated with a temporal or parietal bone fracture. Epidural hematoma tends to expand rapidly, compressing the dura and underlying brain. Clinical features may include HEADACHE; VOMITING; HEMIPARESIS; and impaired mental function.	""	0	#FFFFFF
D006408	C10.228.140.300.535.450.400|C10.900.300.837.600|C14.907.253.573.400.450|C23.550.414.838.700|C23.550.414.913.700|C26.915.300.490.450	Hematoma, Subdural	Accumulation of blood in the SUBDURAL SPACE between the DURA MATER and the arachnoidal layer of the MENINGES. This condition primarily occurs over the surface of a CEREBRAL HEMISPHERE, but may develop in the spinal canal (HEMATOMA, SUBDURAL, SPINAL). Subdural hematoma can be classified as the acute or the chronic form, with immediate or delayed symptom onset, respectively. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.	""	0	#FFFFFF
D006409	C12.050.351.500.852.495|C12.100.250.852.495	Hematometra	Blood-filled UTERUS.	""	0	#FFFFFF
D006417	C12.050.351.968.934.442|C12.200.777.934.442|C12.950.934.442|C23.550.414.849	Hematuria	Presence of blood in the urine.	""	0	#FFFFFF
D006423	C10.597.751.941.512|C11.966.075.500|C23.888.592.763.941.512	Hemianopsia	Partial or complete loss of vision in one half of the visual field(s) of one or both eyes. Subtypes include altitudinal hemianopsia, characterized by a visual defect above or below the horizontal meridian of the visual field. Homonymous hemianopsia refers to a visual defect that affects both eyes equally, and occurs either to the left or right of the midline of the visual field. Binasal hemianopsia consists of loss of vision in the nasal hemifields of both eyes. Bitemporal hemianopsia is the bilateral loss of vision in the temporal fields. Quadrantanopsia refers to loss of vision in one quarter of the visual field in one or both eyes.	""	0	#FFFFFF
D006425	C15	Hemic and Lymphatic Diseases	Hematologic diseases and diseases of the lymphatic system collectively. Hemic diseases include disorders involving the formed elements (e.g., ERYTHROCYTE AGGREGATION, INTRAVASCULAR) and chemical components (e.g., BLOOD PROTEIN DISORDERS); lymphatic diseases include disorders relating to lymph, lymph nodes, and lymphocytes.	""	0	#FFFFFF
D006429	C10.597.622.295|C23.888.592.636.312	Hemiplegia	Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.	""	0	#FFFFFF
D006431	C23.550.414.864	Hemobilia	Hemorrhage in or through the BILIARY TRACT due to trauma, inflammation, CHOLELITHIASIS, vascular disease, or neoplasms.	""	0	#FFFFFF
D006432	C16.320.565.618.337|C18.452.565.500.480|C18.452.648.618.337	Hemochromatosis	A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)	""	0	#FFFFFF
D006445	C15.378.071.141.150.490|C15.378.420.463|C16.320.070.490|C16.320.365.463	Hemoglobin C Disease	A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.	""	0	#FFFFFF
D006450	C15.378.071.141.150.150.440|C15.378.420.155.440|C16.320.070.150.440|C16.320.365.155.440	Hemoglobin SC Disease	One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.	""	0	#FFFFFF
D006453	C15.378.420|C16.320.365	Hemoglobinopathies	A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.	""	0	#FFFFFF
D006456	C12.050.351.968.934.734.634|C12.200.777.934.734.634|C12.950.934.734.634|C23.888.942.750.634	Hemoglobinuria	The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.	""	0	#FFFFFF
D006457	C15.378.071.141.560|C15.378.190.625.460	Hemoglobinuria, Paroxysmal	A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.	""	0	#FFFFFF
D006461	C23.550.403	Hemolysis	The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	""	0	#FFFFFF
D006463	C12.050.351.968.419.936.463|C12.200.777.419.936.463|C12.950.419.936.463|C15.378.071.141.610|C15.378.140.855.925.500	Hemolytic-Uremic Syndrome	A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.	""	0	#FFFFFF
D006465	C06.844.400|C23.550.414.888	Hemoperitoneum	Accumulations of blood in the PERITONEAL CAVITY due to internal HEMORRHAGE.	""	0	#FFFFFF
D006467	C15.378.100.100.500|C15.378.100.141.500|C15.378.463.500|C16.320.099.500	Hemophilia A	The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.	""	0	#FFFFFF
D006468	C08.528.338|C23.550.414.904.500	Hemopneumothorax	Collection of air and blood in the pleural cavity.	""	0	#FFFFFF
D006469	C08.381.348|C23.550.414.896|C23.888.852.430	Hemoptysis	Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.	""	0	#FFFFFF
D006470	C23.550.414	Hemorrhage	Bleeding or escape of blood from a vessel.	""	0	#FFFFFF
D006471	C06.405.227|C23.550.414.788	Gastrointestinal Hemorrhage	Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.	""	0	#FFFFFF
D006472	C07.465.625|C23.550.414.922|C23.888.619.500	Oral Hemorrhage	Bleeding from the blood vessels of the mouth, which may occur as a result of injuries to the mouth, accidents in oral surgery, or diseases of the gums.	""	0	#FFFFFF
D006473	C12.050.703.420.725|C12.050.703.844.700|C23.550.414.993.850	Postpartum Hemorrhage	Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).	""	0	#FFFFFF
D006474	C15.378.463	Hemorrhagic Disorders	Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).	""	0	#FFFFFF
D006475	C15.378.100.920.360|C15.378.463.841.464|C16.614.940|C18.654.422.360|C18.654.521.500.133.912.360	Vitamin K Deficiency Bleeding	Hemorrhage caused by vitamin K deficiency.	""	0	#FFFFFF
D006478	C01.925.782.082.440|C01.925.782.417.400	Hemorrhagic Fever, American	Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).	""	0	#FFFFFF
D006479	C01.920.500.528|C01.920.930.430|C01.925.081.522|C01.925.782.147.444|C01.925.782.417.412	Hemorrhagic Fever, Crimean	A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).	""	0	#FFFFFF
D006480	C01.925.782.147.420.400|C01.925.782.417.300	Hemorrhagic Fever with Renal Syndrome	An acute febrile disease occurring predominately in Asia. It is characterized by fever, prostration, vomiting, hemorrhagic phenonema, shock, and renal failure. It is caused by any one of several closely related species of the genus Hantavirus. The most severe form is caused by HANTAAN VIRUS whose natural host is the rodent Apodemus agrarius. Milder forms are caused by SEOUL VIRUS and transmitted by the rodents Rattus rattus and R. norvegicus, and the PUUMALA VIRUS with transmission by Clethrionomys galreolus.	""	0	#FFFFFF
D006481	C01.920.930.440|C01.925.081.611|C01.925.782.350.250.560|C01.925.782.417.435	Hemorrhagic Fever, Omsk	Infection with the Omsk hemorrhagic fever virus, a Flavivirus.	""	0	#FFFFFF
D006482	C01.925.782.417	Hemorrhagic Fevers, Viral	A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.	""	0	#FFFFFF
D006483	C01.150.252.100.375|C01.150.252.400.700.662.500|C01.757.100.375|C23.550.470.790.500.100.375	Hemorrhagic Septicemia	Any of several bacterial diseases, usually caused by PASTEURELLA MULTOCIDA, marked by the presence of hemorrhagic areas in the subcutaneous tissues, serous membranes, muscles, lymph glands, and throughout the internal organs. The diseases primarily affect animals and rarely humans.	""	0	#FFFFFF
D006484	C06.405.469.860.401|C14.907.449	Hemorrhoids	Swollen veins in the lower part of the RECTUM or ANUS. Hemorrhoids can be inside the anus (internal), under the skin around the anus (external), or protruding from inside to outside of the anus. People with hemorrhoids may or may not exhibit symptoms which include bleeding, itching, and pain.	""	0	#FFFFFF
D006486	C18.452.565.500.500	Hemosiderosis	Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.	""	0	#FFFFFF
D006491	C08.528.380|C23.550.414.904	Hemothorax	Hemorrhage within the pleural cavity.	""	0	#FFFFFF
D006501	C06.552.308.500.356|C10.228.140.163.360|C18.452.132.360	Hepatic Encephalopathy	A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)	""	0	#FFFFFF
D006502	C06.552.347|C14.907.355.830.925.275	Budd-Chiari Syndrome	A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon.	""	0	#FFFFFF
D006504	C06.552.360|C14.907.460	Hepatic Veno-Occlusive Disease	Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.	""	0	#FFFFFF
D006505	C06.552.380	Hepatitis	INFLAMMATION of the LIVER.	""	0	#FFFFFF
D006506	C01.925.440.420|C01.925.782.687.359.500|C06.552.380.705.422	Hepatitis A	INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.	""	0	#FFFFFF
D006509	C01.221.250.500|C01.925.256.430.400|C01.925.440.435|C06.552.380.705.437	Hepatitis B	INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	""	0	#FFFFFF
D006519	C06.552.380.290|C06.552.645.490|C25.775.100.087.645.490	Hepatitis, Alcoholic	INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.	""	0	#FFFFFF
D006520	C01.436|C06.552.380.315|C22.467	Hepatitis, Animal	INFLAMMATION of the LIVER in non-human animals.	""	0	#FFFFFF
D006521	C06.552.380.350|C23.550.291.500.477	Hepatitis, Chronic	INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.	""	0	#FFFFFF
D006522	C01.436.430.440|C01.925.256.076.381|C01.925.407.432|C06.552.380.315.430.440|C22.268.465|C22.467.435.442	Hepatitis, Infectious Canine	A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.	""	0	#FFFFFF
D006524	C01.436.430|C01.925.407|C06.552.380.315.430|C22.467.435	Hepatitis, Viral, Animal	INFLAMMATION of the LIVER in animals due to viral infection.	""	0	#FFFFFF
D006525	C01.925.440|C06.552.380.705	Hepatitis, Viral, Human	INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).	""	0	#FFFFFF
D006526	C01.221.250.750|C01.925.440.440|C01.925.782.350.350|C06.552.380.705.440	Hepatitis C	INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.	""	0	#FFFFFF
D006527	C06.552.413|C10.228.140.079.493|C10.228.140.163.100.360|C10.228.662.400|C10.574.500.487|C16.320.400.361|C16.320.565.189.360|C16.320.565.618.403|C18.452.132.100.360|C18.452.648.189.360|C18.452.648.618.403	Hepatolenticular Degeneration	A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.	""	0	#FFFFFF
D006528	C04.557.470.200.025.255|C04.588.274.623.160|C06.301.623.160|C06.552.697.160	Carcinoma, Hepatocellular	A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	""	0	#FFFFFF
D006529	C06.552.416|C23.300.775.525	Hepatomegaly	Enlargement of the liver.	""	0	#FFFFFF
D006530	C06.552.465|C12.050.351.968.419.291|C12.200.777.419.291|C12.950.419.291	Hepatorenal Syndrome	Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.	""	0	#FFFFFF
D006547	C23.300.707	Hernia	Protrusion of tissue, structure, or part of an organ through the bone, muscular tissue, or the membrane by which it is normally contained. Hernia may involve tissues such as the ABDOMINAL WALL or the respiratory DIAPHRAGM. Hernias may be internal, external, congenital, or acquired.	""	0	#FFFFFF
D006548	C23.300.707.960.500	Hernia, Diaphragmatic	Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.	""	0	#FFFFFF
D006549	C23.300.707.960.500.233|C26.017.258	Hernia, Diaphragmatic, Traumatic	The type of DIAPHRAGMATIC HERNIA caused by TRAUMA or injury, usually to the ABDOMEN.	""	0	#FFFFFF
D006550	C23.300.707.374.750	Hernia, Femoral	A groin hernia occurring inferior to the inguinal ligament and medial to the FEMORAL VEIN and FEMORAL ARTERY. The femoral hernia sac has a small neck but may enlarge considerably when it enters the subcutaneous tissue of the thigh. It is caused by defects in the ABDOMINAL WALL.	""	0	#FFFFFF
D006551	C23.300.707.960.500.467	Hernia, Hiatal	STOMACH herniation located at or near the diaphragmatic opening for the ESOPHAGUS, the esophageal hiatus.	""	0	#FFFFFF
D006552	C23.300.707.374.875	Hernia, Inguinal	An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.	""	0	#FFFFFF
D006553	C23.300.707.937	Hernia, Obturator	A pelvic hernia through the obturator foramen, a large aperture in the hip bone normally covered by a membrane. Obturator hernia can lead to intestinal incarceration and INTESTINAL OBSTRUCTION.	""	0	#FFFFFF
D006554	C16.614.378|C23.300.707.374.937.500	Hernia, Umbilical	A HERNIA due to an imperfect closure or weakness of the umbilical ring. It appears as a skin-covered protrusion at the UMBILICUS during crying, coughing, or straining. The hernia generally consists of OMENTUM or SMALL INTESTINE. The vast majority of umbilical hernias are congenital but can be acquired due to severe abdominal distention.	""	0	#FFFFFF
D006555	C23.300.707.374.937	Hernia, Ventral	A hernia caused by weakness of the anterior ABDOMINAL WALL due to midline defects, previous incisions, or increased intra-abdominal pressure. Ventral hernias include UMBILICAL HERNIA, incisional, epigastric, and spigelian hernias.	""	0	#FFFFFF
D006556	C25.775.643.500.400	Heroin Dependence	Strong dependence or addiction, both physiological and emotional, upon HEROIN.	""	0	#FFFFFF
D006557	C01.925.782.687.359.213.466|C01.925.782.687.359.347.500	Herpangina	Acute types of coxsackievirus infections or ECHOVIRUS INFECTIONS that usually affect children during the summer and are characterized by vesiculoulcerative lesions on the MUCOUS MEMBRANES of the THROAT; DYSPHAGIA; VOMITING, and FEVER.	""	0	#FFFFFF
D006558	C01.221.812.640.350|C01.778.640.350|C01.925.256.466.382.290|C01.925.813.350|C12.050.351.500.342|C12.100.250.342|C12.100.500.329|C12.100.937.640.350|C12.200.294.329	Herpes Genitalis	Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.	""	0	#FFFFFF
D006559	C12.050.703.570|C17.800.865.700	Pemphigoid Gestationis	An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).	""	0	#FFFFFF
D006560	C01.925.256.466.382.316|C01.925.825.320.320|C07.465.409.466|C17.800.838.790.320.320	Herpes Labialis	Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)	""	0	#FFFFFF
D006561	C01.925.256.466.382|C01.925.825.320|C17.800.838.790.320	Herpes Simplex	A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	""	0	#FFFFFF
D006562	C01.925.256.466.930.750	Herpes Zoster	An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)	""	0	#FFFFFF
D006563	C01.375.725.450|C01.925.256.466.930.750.466|C01.925.325.450|C11.294.800.450	Herpes Zoster Ophthalmicus	Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve.	""	0	#FFFFFF
D006566	C01.925.256.466	Herpesviridae Infections	Virus diseases caused by the HERPESVIRIDAE.	""	0	#FFFFFF
D006606	C23.888.821.578	Hiccup	A spasm of the diaphragm that causes a sudden inhalation followed by rapid closure of the glottis which produces a sound.	""	0	#FFFFFF
D006607	C04.557.470.035.175|C04.557.470.550.175	Adenoma, Sweat Gland	A benign neoplasm derived from epithelial cells of sweat glands. (Stedman, 25th ed)	""	0	#FFFFFF
D006610	C10.228.566|C24.410	High Pressure Neurological Syndrome	A syndrome related to increased atmospheric pressure and characterized by tremors, nausea, dizziness, decreased motor and mental performance, and SEIZURES. This condition may occur in those who dive deeply (c. 1000 ft) usually while breathing a mixture of oxygen and helium. The condition is associated with a neuroexcitatory effect of helium.	""	0	#FFFFFF
D006616	C05.550.323.468|C05.651.197.468	Hip Contracture	Permanent fixation of the hip in primary positions, with limited passive or active motion at the hip joint. Locomotion is difficult and pain is sometimes present when the hip is in motion. It may be caused by trauma, infection, or poliomyelitis. (From Current Medical Information & Technology, 5th ed)	""	0	#FFFFFF
D006617	C05.550.518.384|C26.289.384|C26.531.500	Hip Dislocation	Displacement of the femur bone from its normal position at the HIP JOINT.	""	0	#FFFFFF
D006618	C05.660.297.500|C16.131.621.297.500|C16.131.621.449	Hip Dislocation, Congenital	Congenital dislocation of the hip generally includes subluxation of the femoral head, acetabular dysplasia, and complete dislocation of the femoral head from the true acetabulum. This condition occurs in approximately 1 in 1000 live births and is more common in females than in males.	""	0	#FFFFFF
D006619	C22.268.485	Hip Dysplasia, Canine	A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.	""	0	#FFFFFF
D006620	C26.404.061.425|C26.531.750|C26.558.276.425	Hip Fractures	Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).	""	0	#FFFFFF
D006623	C10.562.925|C14.907.077.925|C16.131.077.245.750|C16.320.184.750	von Hippel-Lindau Disease	An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions.	""	0	#FFFFFF
D006627	C06.198.439|C06.405.469.158.701.439|C16.131.314.439	Hirschsprung Disease	Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.	""	0	#FFFFFF
D006628	C17.800.329.750|C23.888.971.468	Hirsutism	A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.	""	0	#FFFFFF
D006646	C08.381.483.375|C15.604.250.400	Histiocytosis, Langerhans-Cell	A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.	""	0	#FFFFFF
D006660	C01.150.703.450	Histoplasmosis	Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.	""	0	#FFFFFF
D006679	C01.221.250.875.500|C01.221.812.640.400.500|C01.778.640.400.500|C01.925.782.815.616.400.500|C01.925.813.400.500|C12.100.937.640.400.500|C20.673.480.500	HIV Seropositivity	Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV).	""	0	#FFFFFF
D006685	C08.360.940.490|C08.618.490|C09.400.940.490|C10.597.975.550|C23.888.592.979.550|C23.888.852.490	Hoarseness	An unnaturally deep or rough quality of voice.	""	0	#FFFFFF
D006689	C04.557.386.355|C15.604.515.569.355|C20.683.515.761.355	Hodgkin Disease	A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.	""	0	#FFFFFF
D006691	C01.925.782.350.675.200|C22.905.170	Classical Swine Fever	An acute, highly contagious disease affecting swine of all ages and caused by the CLASSICAL SWINE FEVER VIRUS. It has a sudden onset with high morbidity and mortality.	""	0	#FFFFFF
D006712	C10.228.140.163.100.365|C16.320.565.100.480.500|C16.320.565.189.365|C17.300.428|C18.452.132.100.365|C18.452.648.100.480.500|C18.452.648.189.365	Homocystinuria	Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)	""	0	#FFFFFF
D006725	C01.610.335.508.700.775.455	Hookworm Infections	Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.	""	0	#FFFFFF
D006726	C01.150.252.289.400|C01.375.354.400|C11.294.354.400|C11.338.648	Hordeolum	Purulent infection of one of the sebaceous glands of Zeis along the eyelid margin (external) or of the meibomian gland on the conjunctival side of the eyelid (internal).	""	0	#FFFFFF
D006732	C10.177.350|C10.597.690.362.500|C11.710.528.500|C23.888.592.708.362.500	Horner Syndrome	A syndrome associated with defective sympathetic innervation to one side of the face, including the eye. Clinical features include MIOSIS; mild BLEPHAROPTOSIS; and hemifacial ANHIDROSIS (decreased sweating)(see HYPOHIDROSIS). Lesions of the BRAIN STEM; cervical SPINAL CORD; first thoracic nerve root; apex of the LUNG; CAROTID ARTERY; CAVERNOUS SINUS; and apex of the ORBIT may cause this condition. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp500-11)	""	0	#FFFFFF
D006734	C22.488	Horse Diseases	Diseases of domestic and wild horses of the species Equus caballus.	""	0	#FFFFFF
D006800	C01.925.782.815.200|C20.673.483	Deltaretrovirus Infections	Infections caused by the HTLV or BLV deltaretroviruses. They include human T-cell leukemia-lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED).	""	0	#FFFFFF
D006810	C26.088.390|C26.404.500	Humeral Fractures	Fractures of the HUMERUS.	""	0	#FFFFFF
D006816	C10.228.140.079.545|C10.228.140.380.278|C10.228.662.262.249.750|C10.574.500.497|C16.320.400.430	Huntington Disease	A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)	""	0	#FFFFFF
D006819	C08.381.840.500.475|C08.618.840.500.475|C16.614.521.563.475	Hyaline Membrane Disease	A respiratory distress syndrome in newborn infants, usually premature infants with insufficient PULMONARY SURFACTANTS. The disease is characterized by the formation of a HYALINE-like membrane lining the terminal respiratory airspaces (PULMONARY ALVEOLI) and subsequent collapse of the lung (PULMONARY ATELECTASIS).	""	0	#FFFFFF
D006828	C04.557.465.955.416.812|C04.850.908.416.750|C12.050.703.720.949.416.875	Hydatidiform Mole	Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.	""	0	#FFFFFF
D006831	C12.050.703.610	Polyhydramnios	A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.	""	0	#FFFFFF
D006832	C10.500.450|C16.131.666.450	Hydranencephaly	A congenital condition where the greater portions of the cerebral hemispheres and CORPUS STRIATUM are replaced by CSF and glial tissue. The meninges and the skull are well formed, which is consistent with earlier normal embryogenesis of the telencephalon. Bilateral occlusions of the internal carotid arteries in utero is a potential mechanism. Clinical features include intact brainstem reflexes without evidence of higher cortical activity. (Menkes, Textbook of Child Neurology, 5th ed, p307)	""	0	#FFFFFF
D006833	C05.550.509	Hydrarthrosis	Accumulation of watery fluid in the cavity of a joint. (Dorland, 27th ed)	""	0	#FFFFFF
D006837	C17.800.600.425|C17.800.865.575	Hydroa Vacciniforme	A vesicular and bullous eruption having a tendency to recur in summer during childhood and commonly appearing on sun-exposed skin. The lesions are surrounded by an erythematous zone and resemble a vaccination. (From Dorland, 27th ed)	""	0	#FFFFFF
D006848	C12.100.500.882|C12.200.294.882	Testicular Hydrocele	Accumulation of serous fluid between the layers of membrane (tunica vaginalis) covering the TESTIS in the SCROTUM.	""	0	#FFFFFF
D006849	C10.228.140.602	Hydrocephalus	Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA.	""	0	#FFFFFF
D006850	C10.228.140.602.750	Hydrocephalus, Normal Pressure	A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see GAIT DISORDERS, NEUROLOGIC), progressive intellectual decline, and URINARY INCONTINENCE. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of CSF including SUBARACHNOID HEMORRHAGE, chronic MENINGITIS, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)	""	0	#FFFFFF
D006869	C12.050.351.968.419.307|C12.200.777.419.307|C12.950.419.307	Hydronephrosis	Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.	""	0	#FFFFFF
D006871	C11.250.480|C11.525.381.407.480|C16.131.384.480|C16.614.438	Hydrophthalmos	Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.	""	0	#FFFFFF
D006872	C08.528.434	Hydropneumothorax	A collection of fluid and gas within the pleural cavity. (Dorland, 27th ed)	""	0	#FFFFFF
D006876	C08.528.476	Hydrothorax	A collection of watery fluid in the pleural cavity. (Dorland, 27th ed)	""	0	#FFFFFF
D006925	C01.610.335.190.519	Hymenolepiasis	Infection with tapeworms of the genus Hymenolepis.	""	0	#FFFFFF
D006929	C19.053.800.604	Hyperaldosteronism	A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.	""	0	#FFFFFF
D006930	C10.597.751.791.400|C23.888.592.763.770.400	Hyperalgesia	An increased sensation of pain or discomfort produced by minimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.	""	0	#FFFFFF
D006932	C23.550.429	Hyperbilirubinemia	A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.	""	0	#FFFFFF
D006933	C16.320.565.300|C18.452.648.300	Hyperbilirubinemia, Hereditary	Inborn errors of bilirubin metabolism resulting in excessive amounts of bilirubin in the circulating blood, either because of increased bilirubin production or because of delayed clearance of bilirubin from the blood.	""	0	#FFFFFF
D006934	C18.452.174.451|C18.452.950.340	Hypercalcemia	Abnormally high level of calcium in the blood.	""	0	#FFFFFF
D006935	C23.888.852.544	Hypercapnia	A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.	""	0	#FFFFFF
D006936	C07.793.422	Hypercementosis	A regressive change of teeth characterized by excessive development of secondary cementum on the tooth surface. It may occur on any part of the root, but the apical two-thirds are most commonly affected. (Dorland, 27th ed)	""	0	#FFFFFF
D006937	C18.452.584.500.500.396	Hypercholesterolemia	A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.	""	0	#FFFFFF
D006938	C16.320.565.398.481|C18.452.584.500.500.644.475|C18.452.584.563.481|C18.452.648.398.481	Hyperlipoproteinemia Type II	A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins).	""	0	#FFFFFF
D006939	C12.050.703.407.500|C23.888.821.937.049.500	Hyperemesis Gravidarum	Intractable VOMITING that develops in early PREGNANCY and persists. This can lead to DEHYDRATION and WEIGHT LOSS.	""	0	#FFFFFF
D006940	C14.907.474	Hyperemia	The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).	""	0	#FFFFFF
D006941	C10.597.751.791.450|C23.888.592.763.770.450	Hyperesthesia	Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.	""	0	#FFFFFF
D006942	C15.378.147.542|C20.683.460|C23.888.512	Hypergammaglobulinemia	An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.	""	0	#FFFFFF
D006943	C18.452.394.952	Hyperglycemia	Abnormally high BLOOD GLUCOSE level.	""	0	#FFFFFF
D006944	C19.246.099.750.490	Hyperglycemic Hyperosmolar Nonketotic Coma	A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.	""	0	#FFFFFF
D006945	C17.800.946.350	Hyperhidrosis	Excessive sweating. In the localized type, the most frequent sites are the palms, soles, axillae, inguinal folds, and the perineal area. Its chief cause is thought to be emotional. Generalized hyperhidrosis may be induced by a hot, humid environment, by fever, or by vigorous exercise.	""	0	#FFFFFF
D006946	C18.452.394.968	Hyperinsulinism	A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.	""	0	#FFFFFF
D006947	C18.452.950.396	Hyperkalemia	Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)	""	0	#FFFFFF
D006948	C10.597.350.350|C23.888.592.350.350	Hyperkinesis	Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.	""	0	#FFFFFF
D006949	C18.452.584.500.500	Hyperlipidemias	Conditions with excess LIPIDS in the blood.	""	0	#FFFFFF
D006950	C16.320.565.398.450|C18.452.584.500.500.438|C18.452.584.563.450|C18.452.648.398.450	Hyperlipidemia, Familial Combined	A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.	""	0	#FFFFFF
D006951	C18.452.584.500.500.644	Hyperlipoproteinemias	Conditions with abnormally elevated levels of LIPOPROTEINS in the blood. They may be inherited, acquired, primary, or secondary. Hyperlipoproteinemias are classified according to the pattern of lipoproteins on electrophoresis or ultracentrifugation.	""	0	#FFFFFF
D006952	C16.320.565.398.483|C18.452.584.500.500.644.485|C18.452.584.563.483|C18.452.648.398.483	Hyperlipoproteinemia Type III	An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.	""	0	#FFFFFF
D006953	C16.320.565.398.487|C18.452.584.500.500.644.490|C18.452.584.500.500.851.500|C18.452.584.563.487|C18.452.648.398.487	Hyperlipoproteinemia Type IV	A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.	""	0	#FFFFFF
D006954	C16.320.565.398.493|C18.452.584.500.500.644.495|C18.452.584.500.500.851.750|C18.452.584.563.493|C18.452.648.398.493	Hyperlipoproteinemia Type V	A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .	""	0	#FFFFFF
D006955	C18.452.950.452	Hypernatremia	Excessive amount of sodium in the blood. (Dorland, 27th ed)	""	0	#FFFFFF
D006956	C11.744.479	Hyperopia	A refractive error in which rays of light entering the eye parallel to the optic axis are brought to a focus behind the retina, as a result of the eyeball being too short from front to back. It is also called farsightedness because the near point is more distant than it is in emmetropia with an equal amplitude of accommodation. (Dorland, 27th ed)	""	0	#FFFFFF
D006957	C05.116.099.708.486|C05.116.540.420	Hyperostosis Frontalis Interna	Thickening of the inner table of the frontal bone, which may be associated with hypertrichosis and obesity. It most commonly affects women near menopause.	""	0	#FFFFFF
D006958	C05.116.099.708.479|C05.116.540.400|C16.614.465	Hyperostosis, Cortical, Congenital	A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)	""	0	#FFFFFF
D006959	C12.050.351.968.419.313|C12.200.777.419.313|C12.950.419.313	Hyperoxaluria	Excretion of an excessive amount of OXALATES in the urine.	""	0	#FFFFFF
D006960	C12.050.351.968.419.313.500|C12.200.777.419.313.500|C12.950.419.313.500|C16.320.565.202.460|C18.452.648.202.460	Hyperoxaluria, Primary	A genetic disorder characterized by excretion of large amounts of OXALATES in urine; NEPHROLITHIASIS; NEPHROCALCINOSIS; early onset of RENAL FAILURE; and often a generalized deposit of CALCIUM OXALATE. There are subtypes classified by the enzyme defects in glyoxylate metabolism.	""	0	#FFFFFF
D006961	C19.642.355	Hyperparathyroidism	A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.	""	0	#FFFFFF
D006962	C19.642.355.480	Hyperparathyroidism, Secondary	Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.	""	0	#FFFFFF
D006963	C23.888.821.645	Hyperphagia	Ingestion of a greater than optimal quantity of food.	""	0	#FFFFFF
D006964	C10.228.140.617.738.250|C19.700.355	Hyperpituitarism	Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.	""	0	#FFFFFF
D006965	C23.550.444	Hyperplasia	An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	""	0	#FFFFFF
D006966	C10.228.140.617.738.250.450|C19.700.355.600	Hyperprolactinemia	Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)	""	0	#FFFFFF
D006967	C20.543	Hypersensitivity	Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	""	0	#FFFFFF
D006968	C20.543.418	Hypersensitivity, Delayed	An increased reactivity to specific antigens mediated not by antibodies but by cells.	""	0	#FFFFFF
D006969	C20.543.480	Hypersensitivity, Immediate	Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.	""	0	#FFFFFF
D006970	C10.886.425.800.200	Disorders of Excessive Somnolence	Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)	""	0	#FFFFFF
D006971	C15.604.744.293	Hypersplenism	Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.	""	0	#FFFFFF
D006972	C05.116.099.370.231.480|C05.660.207.231.480|C16.131.621.207.231.480	Hypertelorism	Abnormal increase in the interorbital distance due to overdevelopment of the lesser wings of the sphenoid.	""	0	#FFFFFF
D006973	C14.907.489	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	""	0	#FFFFFF
D006974	C14.907.489.330	Hypertension, Malignant	A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.	""	0	#FFFFFF
D006975	C06.552.494	Hypertension, Portal	Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.	""	0	#FFFFFF
D006976	C08.381.423|C14.907.489.556	Hypertension, Pulmonary	Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.	""	0	#FFFFFF
D006977	C12.050.351.968.419.331|C12.200.777.419.331|C12.950.419.331|C14.907.489.631	Hypertension, Renal	Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.	""	0	#FFFFFF
D006978	C12.050.351.968.419.331.490|C12.200.777.419.331.490|C12.950.419.331.490|C14.907.489.631.485	Hypertension, Renovascular	Hypertension due to RENAL ARTERY OBSTRUCTION or compression.	""	0	#FFFFFF
D006980	C19.874.397	Hyperthyroidism	Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.	""	0	#FFFFFF
D006981	C19.874.410	Hyperthyroxinemia	Abnormally elevated THYROXINE level in the BLOOD.	""	0	#FFFFFF
D006983	C17.800.329.875	Hypertrichosis	Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.	""	0	#FFFFFF
D006984	C23.300.775	Hypertrophy	General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).	""	0	#FFFFFF
D006985	C08.618.501|C23.888.852.591	Hyperventilation	A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.	""	0	#FFFFFF
D006986	C18.654.301	Hypervitaminosis A	A symptom complex resulting from ingesting excessive amounts of VITAMIN A.	""	0	#FFFFFF
D006987	C10.597.751.791.500|C23.888.592.763.770.500	Hypesthesia	Absent or reduced sensitivity to cutaneous stimulation.	""	0	#FFFFFF
D006988	C11.290.484|C23.550.414.756.550	Hyphema	Bleeding in the anterior chamber of the eye.	""	0	#FFFFFF
D006994	C19.053.500.480	Hypoaldosteronism	A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.	""	0	#FFFFFF
D006995	C16.320.565.398.500.440|C18.452.584.500.875.440|C18.452.584.563.500.440|C18.452.648.398.500.440	Hypobetalipoproteinemias	Conditions with abnormally low levels of BETA-LIPOPROTEINS (low density lipoproteins or LDL) in the blood. It is defined as LDL values equal to or less than the 5th percentile for the population. They include the autosomal dominant form involving mutation of the APOLIPOPROTEINS B gene, and the autosomal recessive form involving mutation of the microsomal triglyceride transfer protein. All are characterized by low LDL and dietary fat malabsorption.	""	0	#FFFFFF
D006996	C18.452.174.509|C18.452.950.509	Hypocalcemia	Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)	""	0	#FFFFFF
D007000	C01.610.858.211.503.398	Hypodermyiasis	Infestation with larvae of the genus Hypoderma, the warble fly.	""	0	#FFFFFF
D007003	C18.452.394.984	Hypoglycemia	A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.	""	0	#FFFFFF
D007006	C19.391.482	Hypogonadism	Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).	""	0	#FFFFFF
D007007	C17.800.946.370	Hypohidrosis	Abnormally diminished or absent perspiration. Both generalized and segmented (reduced or absent sweating in circumscribed locations) forms of the disease are usually associated with other underlying conditions.	""	0	#FFFFFF
D007008	C18.452.950.565	Hypokalemia	Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)	""	0	#FFFFFF
D007009	C16.320.565.398.500|C18.452.584.500.875|C18.452.584.563.500|C18.452.648.398.500	Hypolipoproteinemias	Conditions with abnormally low levels of LIPOPROTEINS in the blood. This may involve any of the lipoprotein subclasses, including ALPHA-LIPOPROTEINS (high-density lipoproteins); BETA-LIPOPROTEINS (low-density lipoproteins); and PREBETA-LIPOPROTEINS (very-low-density lipoproteins).	""	0	#FFFFFF
D007010	C18.452.950.620	Hyponatremia	Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)	""	0	#FFFFFF
D007011	C19.642.482	Hypoparathyroidism	A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.	""	0	#FFFFFF
D007012	C04.588.443.665.710.485|C07.550.745.436|C09.647.710.485|C09.775.549.485	Hypopharyngeal Neoplasms	Tumors or cancer of the HYPOPHARYNX.	""	0	#FFFFFF
D007014	C16.320.565.618.482|C18.452.648.618.482	Hypophosphatasia	A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)	""	0	#FFFFFF
D007015	C12.050.351.968.419.815.647|C12.200.777.419.815.647|C12.950.419.815.647|C16.320.565.618.544|C16.320.831.647|C18.452.648.618.544|C18.452.750.400.500	Hypophosphatemia, Familial	An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.	""	0	#FFFFFF
D007018	C10.228.140.617.738.300|C19.700.482	Hypopituitarism	Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.	""	0	#FFFFFF
D007019	C15.378.147.607	Hypoproteinemia	A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.	""	0	#FFFFFF
D007020	C15.378.100.100.550|C15.378.100.141.550|C15.378.463.550|C16.320.099.550	Hypoprothrombinemias	Absence or reduced levels of PROTHROMBIN in the blood.	""	0	#FFFFFF
D007021	C12.050.351.875.466|C12.100.500.494.400|C12.200.294.494.400|C12.200.706.516|C12.800.516|C16.131.939.516	Hypospadias	A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.	""	0	#FFFFFF
D007022	C14.907.514	Hypotension	Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	""	0	#FFFFFF
D007024	C10.177.575.600.450|C14.907.514.482	Hypotension, Orthostatic	A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.	""	0	#FFFFFF
D007027	C10.228.140.617	Hypothalamic Diseases	Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; AUTONOMIC NERVOUS SYSTEM DISEASES; SLEEP DISORDERS; behavioral symptoms related to dysfunction of the LIMBIC SYSTEM; and neuroendocrine disorders.	""	0	#FFFFFF
D007029	C04.588.614.250.195.885.500|C10.228.140.211.885.500|C10.228.140.617.477|C10.551.240.250.700.500	Hypothalamic Neoplasms	Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestations include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)	""	0	#FFFFFF
D007035	C23.888.119.565	Hypothermia	Lower than normal body temperature, especially in warm-blooded animals.	""	0	#FFFFFF
D007037	C19.874.482	Hypothyroidism	A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.	""	0	#FFFFFF
D007039	C17.800.329.937	Hypotrichosis	Presence of less than the normal amount of hair. (Dorland, 27th ed)	""	0	#FFFFFF
D007040	C08.618.846.565|C23.888.852.638	Hypoventilation	A reduction in the amount of air entering the pulmonary alveoli.	""	0	#FFFFFF
D007049	C23.550.291.875	Iatrogenic Disease	Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.	""	0	#FFFFFF
D007057	C16.131.831.512|C16.614.492|C17.800.428.333|C17.800.804.512	Ichthyosis	Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.	""	0	#FFFFFF
D007077	C06.405.469.420	Ileal Diseases	Pathological development in the ILEUM including the ILEOCECAL VALVE.	""	0	#FFFFFF
D007078	C04.588.274.476.411.501|C06.301.371.411.501|C06.405.249.411.501|C06.405.469.420.501|C06.405.469.491.501	Ileal Neoplasms	Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).	""	0	#FFFFFF
D007079	C06.405.205.462.624|C06.405.469.326.875|C06.405.469.420.520	Ileitis	Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.	""	0	#FFFFFF
D007088	C10.597.606.762.400|C23.888.592.604.764.400	Illusions	The misinterpretation of a real external, sensory experience.	""	0	#FFFFFF
D007102	C17.800.321.500	Immersion Foot	A condition of the feet produced by prolonged exposure of the feet to water. Exposure for 48 hours or more to warm water causes tropical immersion foot or warm-water immersion foot common in Vietnam where troops were exposed to prolonged or repeated wading in paddy fields or streams. Trench foot results from prolonged exposure to cold, without actual freezing. It was common in trench warfare during World War I, when soldiers stood, sometimes for hours, in trenches with a few inches of cold water in them. (Andrews' Diseases of the Skin, 8th ed, p27)	""	0	#FFFFFF
D007105	C20.543.520	Immune Complex Diseases	Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.	""	0	#FFFFFF
D007119	C15.604.338.500|C15.604.515.509|C20.683.515.501	Immunoblastic Lymphadenopathy	A disorder characterized by proliferation of arborizing small vessels, prominent immunoblastic proliferations and amorphous acidophilic interstitial material. Clinical manifestations include fever, sweats, weight loss, generalized lymphadenopathy and frequently hepatosplenomegaly.	""	0	#FFFFFF
D007153	C20.673	Immunologic Deficiency Syndromes	Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.	""	0	#FFFFFF
D007154	C20	Immune System Diseases	Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.	""	0	#FFFFFF
D007160	C20.683	Immunoproliferative Disorders	Disorders characterized by abnormal proliferation of primary cells of the immune system or by excessive production of immunoglobulins.	""	0	#FFFFFF
D007161	C04.557.386.390|C06.301.371.411.512|C06.405.249.411.512|C06.405.469.491.505|C15.378.147.780.490.512|C15.604.515.435.512|C20.683.515.512|C20.683.780.490.512	Immunoproliferative Small Intestinal Disease	A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA.	""	0	#FFFFFF
D007169	C01.150.252.410.868.951.360|C01.150.252.410.890.587|C01.150.252.819.770.360|C01.800.720.770.360|C17.800.838.765.770.360	Impetigo	A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.	""	0	#FFFFFF
D007172	C12.100.500.214|C12.100.875.486|C12.200.294.214	Erectile Dysfunction	The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.	""	0	#FFFFFF
D007177	C10.228.140.617.738.320|C18.452.950.626|C19.700.490	Inappropriate ADH Syndrome	A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.	""	0	#FFFFFF
D007184	C16.131.077.445|C16.131.831.580|C16.320.850.420|C17.800.621.497|C17.800.804.580|C17.800.827.420	Incontinentia Pigmenti	A genodermatosis occurring mostly in females and characterized by skin changes in three phases - vesiculobullous, verrucous papillomatous, and macular melanodermic. Hyperpigmentation is bizarre and irregular. Sixty percent of patients have abnormalities of eyes, teeth, central nervous system, and skin appendages.	""	0	#FFFFFF
D007222	C24.426|C25.723.455.571	Inert Gas Narcosis	Progressive mental disturbances and unconsciousness due to breathing mixtures of oxygen and inert gases (argon, helium, xenon, krypton, and atmospheric nitrogen) at high pressure.	""	0	#FFFFFF
D007228	C18.654.422	Infant Nutrition Disorders	Disorders caused by nutritional imbalance, either overnutrition or undernutrition, occurring in infants ages 1 month to 24 months.	""	0	#FFFFFF
D007232	C16.614	Infant, Newborn, Diseases	Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.	""	0	#FFFFFF
D007235	C16.614.521	Infant, Premature, Diseases	Diseases that occur in PREMATURE INFANTS.	""	0	#FFFFFF
D007238	C23.550.513.355|C23.550.717.489	Infarction	Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.	""	0	#FFFFFF
D007239	C01	Infections	Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.	""	0	#FFFFFF
D007241	C01.925.256.466.488|C22.196.429	Infectious Bovine Rhinotracheitis	A herpesvirus infection of CATTLE characterized by INFLAMMATION and NECROSIS of the mucous membranes of the upper RESPIRATORY TRACT.	""	0	#FFFFFF
D007244	C01.925.256.466.313.400|C15.378.553.381|C15.604.515.516|C20.683.515.515	Infectious Mononucleosis	A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.	""	0	#FFFFFF
D007246	C12.100.750	Infertility	A reduced or absent capacity to reproduce.	""	0	#FFFFFF
D007247	C12.050.351.500.498|C12.100.250.498|C12.100.750.350	Infertility, Female	Diminished or absent ability of a female to achieve conception.	""	0	#FFFFFF
D007248	C12.100.500.430|C12.100.750.700|C12.200.294.430	Infertility, Male	The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.	""	0	#FFFFFF
D007249	C23.550.470	Inflammation	A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	""	0	#FFFFFF
D007251	C01.748.310|C01.925.782.620.365|C08.730.310	Influenza, Human	An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	""	0	#FFFFFF
D007280	C21	Disorders of Environmental Origin	Disorders caused by external forces rather than by physiologic dysfunction or by pathogens.	""	0	#FFFFFF
D007299	C25.723.127.071|C26.176.143	Insect Bites and Stings	Bites and stings inflicted by insects.	""	0	#FFFFFF
D007319	C10.886.425.800.800	Sleep Initiation and Maintenance Disorders	Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.	""	0	#FFFFFF
D007331	C10.597.606.358.800.200.600|C18.452.394.984.492	Insulin Coma	Severe HYPOGLYCEMIA induced by a large dose of exogenous INSULIN resulting in a COMA or profound state of unconsciousness from which the individual cannot be aroused.	""	0	#FFFFFF
D007333	C18.452.394.968.500	Insulin Resistance	Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	""	0	#FFFFFF
D007340	C04.557.470.035.100.852|C04.588.274.761.249.500|C04.588.322.475.249.500|C06.301.761.249.500|C06.689.667.249.500|C19.344.421.249.500	Insulinoma	A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.	""	0	#FFFFFF
D007383	C14.907.137.126.669|C23.888.531	Intermittent Claudication	A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.	""	0	#FFFFFF
D007402	C17.800.174.640|C17.800.815.650	Intertrigo	A superficial dermatitis occurring on skin surfaces in contact with each other, such as the axillae, neck creases, intergluteal fold, between the toes, etc. Obesity is a predisposing factor. The condition is caused by moisture and friction and is characterized by erythema, maceration, burning, and exudation.	""	0	#FFFFFF
D007405	C05.116.900.307|C23.300.707.952	Intervertebral Disc Displacement	An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region.	""	0	#FFFFFF
D007409	C06.198.719|C06.405.469.445|C16.131.314.466	Intestinal Atresia	Congenital obliteration of the lumen of the intestine, with the ILEUM involved in 50% of the cases and the JEJUNUM and DUODENUM following in frequency. It is the most frequent cause of INTESTINAL OBSTRUCTION in NEWBORNS. (From Stedman, 25th ed)	""	0	#FFFFFF
D007410	C06.405.469	Intestinal Diseases	Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.	""	0	#FFFFFF
D007411	C01.610.432|C06.405.469.452	Intestinal Diseases, Parasitic	Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.	""	0	#FFFFFF
D007412	C06.267.550|C06.405.469.471|C23.300.575.185.550	Intestinal Fistula	An abnormal anatomical passage between the INTESTINE, and another segment of the intestine or other organs. External intestinal fistula is connected to the SKIN (enterocutaneous fistula). Internal intestinal fistula can be connected to a number of organs, such as STOMACH (gastrocolic fistula), the BILIARY TRACT (cholecystoduodenal fistula), or the URINARY BLADDER of the URINARY TRACT (colovesical fistula). Risk factors include inflammatory processes, cancer, radiation treatment, and surgical misadventures (MEDICAL ERRORS).	""	0	#FFFFFF
D007414	C04.588.274.476.411|C06.301.371.411|C06.405.249.411|C06.405.469.491	Intestinal Neoplasms	Tumors or cancer of the INTESTINES.	""	0	#FFFFFF
D007415	C06.405.469.531	Intestinal Obstruction	Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.	""	0	#FFFFFF
D007416	C06.405.469.557	Intestinal Perforation	Opening or penetration through the wall of the INTESTINES.	""	0	#FFFFFF
D007417	C23.300.825.411	Intestinal Polyps	Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.	""	0	#FFFFFF
D007418	C06.405.469.531.492.500	Intestinal Pseudo-Obstruction	A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.	""	0	#FFFFFF
D007431	C23.550.505	Intraoperative Complications	Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.	""	0	#FFFFFF
D007443	C06.405.469.531.577	Intussusception	A form of intestinal obstruction caused by the PROLAPSE of a part of the intestine into the adjoining intestinal lumen. There are four types: colic, involving segments of the LARGE INTESTINE; enteric, involving only the SMALL INTESTINE; ileocecal, in which the ILEOCECAL VALVE prolapses into the CECUM, drawing the ILEUM along with it; and ileocolic, in which the ileum prolapses through the ileocecal valve into the COLON.	""	0	#FFFFFF
D007446	C23.550.210.190	Chromosome Inversion	An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.	""	0	#FFFFFF
D007499	C11.941.375	Iris Diseases	Diseases, dysfunctions, or disorders of or located in the iris.	""	0	#FFFFFF
D007500	C11.941.375.385|C11.941.879.780.880.448	Iritis	Inflammation of the iris characterized by circumcorneal injection, aqueous flare, keratotic precipitates, and constricted and sluggish pupil along with discoloration of the iris.	""	0	#FFFFFF
D007511	C23.550.513	Ischemia	A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	""	0	#FFFFFF
D007516	C04.557.470.035.100|C04.588.274.761.249|C04.588.322.475.249|C06.301.761.249|C06.689.667.249|C19.344.421.249	Adenoma, Islet Cell	A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.	""	0	#FFFFFF
D007562	C01.207.800.230|C10.228.140.380.165|C10.228.228.800.230	Creutzfeldt-Jakob Syndrome	A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))	""	0	#FFFFFF
D007565	C23.550.429.500|C23.888.885.375	Jaundice	A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.	""	0	#FFFFFF
D007566	C16.320.565.300.764|C16.614.451.500.250|C18.452.648.300.764|C23.550.291.500.479	Jaundice, Chronic Idiopathic	A benign, autosomally recessive inherited hyperbilirubinemia characterized by the presence of a dark pigment in the centrilobular region of the liver cells. There is a functional defect in biliary excretion of bilirubin, cholephilic dyes, and porphyrins. Affected persons may be asymptomatic or have vague constitutional or gastrointestinal symptoms. The liver may be slightly enlarged, and oral and intravenous cholangiography fails to visualize the biliary tract.	""	0	#FFFFFF
D007567	C16.614.451.500|C23.550.429.249.500	Jaundice, Neonatal	Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.	""	0	#FFFFFF
D007569	C05.500.460|C05.660.207.540.460|C07.320.440|C07.650.500.460|C16.131.621.207.540.460|C16.131.850.500.460	Jaw Abnormalities	Congenital absence of or defects in structures of the jaw.	""	0	#FFFFFF
D007570	C04.182.089.530|C05.500.470|C07.320.450	Jaw Cysts	Saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also nonepithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst. True jaw cysts are classified as odontogenic or nonodontogenic.	""	0	#FFFFFF
D007571	C05.500|C07.320	Jaw Diseases	Diseases involving the JAW.	""	0	#FFFFFF
D007572	C10.900.300.284.500.400|C26.404.750.467|C26.915.300.425.500.400	Jaw Fractures	Fractures of the upper or lower jaw.	""	0	#FFFFFF
D007573	C04.588.149.721.450|C05.116.231.754.450|C05.500.499|C07.320.515	Jaw Neoplasms	Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.	""	0	#FFFFFF
D007575	C05.500.480|C07.320.550|C07.465.550.425|C07.793.597.425	Jaw, Edentulous	The total absence of teeth from either the mandible or the maxilla, but not both. Total absence of teeth from both is MOUTH, EDENTULOUS. Partial absence of teeth in either is JAW, EDENTULOUS, PARTIALLY.	""	0	#FFFFFF
D007576	C05.500.480.450|C07.320.550.450|C07.465.550.425.450|C07.793.597.425.450	Jaw, Edentulous, Partially	Absence of teeth from a portion of the mandible and/or maxilla.	""	0	#FFFFFF
D007579	C06.405.469.600	Jejunal Diseases	Pathological development in the JEJUNUM region of the SMALL INTESTINE.	""	0	#FFFFFF
D007580	C04.588.274.476.411.523|C06.301.371.411.523|C06.405.249.411.523|C06.405.469.491.523|C06.405.469.600.523	Jejunal Neoplasms	Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).	""	0	#FFFFFF
D007589	C15.378.553.774.600|C16.320.798.688|C20.673.774.600|C20.673.795.688	Job Syndrome	Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.	""	0	#FFFFFF
D007592	C05.550	Joint Diseases	Diseases involving the JOINTS.	""	0	#FFFFFF
D007593	C05.550.521	Joint Instability	Lack of stability of a joint or joint prosthesis.	""	0	#FFFFFF
D007594	C05.550.535	Joint Loose Bodies	Fibrous, bony, cartilaginous and osteocartilaginous fragments in a synovial joint. Major causes are osteochondritis dissecans, synovial chondromatosis, osteophytes, fractured articular surfaces and damaged menisci.	""	0	#FFFFFF
D007617	C01.925.256.466.382.410|C01.925.825.320.410|C17.800.838.790.320.410	Kaposi Varicelliform Eruption	A disseminated vesicular-pustular eruption caused by the herpes simplex virus (HERPESVIRUS HOMINIS), the VACCINIA VIRUS, or Varicella zoster (HERPESVIRUS 3, HUMAN). It is usually superimposed on a preexisting, inactive or active, atopic dermatitis (DERMATITIS, ATOPIC).	""	0	#FFFFFF
D007619	C08.127.384.500|C08.200.531|C08.695.501|C09.150.531|C14.240.400.280.500|C14.280.400.280.500|C16.131.077.245.500.531|C16.131.240.400.280.500|C16.131.740.501|C16.131.810.250.500|C16.320.184.500.531|C16.320.480	Kartagener Syndrome	An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts.	""	0	#FFFFFF
D007625	C05.651.460.700.500|C10.292.562.750.250.500|C10.597.622.447.511.500|C10.668.491.500.700.500|C11.590.472.250.500|C11.768.585.658.500.627|C14.280.238.510|C18.452.660.560.700.500|C23.550.291.500.688.500|C23.888.592.636.447.511.500	Kearns-Sayre Syndrome	A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) with conduction block (HEART BLOCK), and RETINITIS PIGMENTOSA. Disease onset is in the first or second decade. Elevated CSF protein, sensorineural deafness, seizures, and pyramidal signs may also be present. Ragged-red fibers are found on muscle biopsy. (Adams et al., Principles of Neurology, 6th ed, p984)	""	0	#FFFFFF
D007627	C17.300.200.425|C23.550.355.274.510	Keloid	A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.	""	0	#FFFFFF
D007634	C11.204.564	Keratitis	Inflammation of the cornea.	""	0	#FFFFFF
D007635	C01.375.725.465.450|C01.925.256.466.382.465.450|C01.925.325.465.450|C11.204.564.425.450|C11.294.800.475.450	Keratitis, Dendritic	A form of herpetic keratitis characterized by the formation of small vesicles which break down and coalesce to form recurring dendritic ulcers, characteristically irregular, linear, branching, and ending in knoblike extremities. (Dictionary of Visual Science, 3d ed)	""	0	#FFFFFF
D007636	C17.800.417	Keratoacanthoma	A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.	""	0	#FFFFFF
D007637	C11.187.183.394|C11.204.564.585	Keratoconjunctivitis	Simultaneous inflammation of the cornea and conjunctiva.	""	0	#FFFFFF
D007638	C11.187.183.394.500|C11.204.564.585.630|C11.496.260.394	Keratoconjunctivitis Sicca	Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.	""	0	#FFFFFF
D007639	C01.150.252.289.450|C01.375.354.450|C11.187.183.394.520|C11.204.564.585.500|C11.294.354.450|C22.500	Keratoconjunctivitis, Infectious	Infectious diseases of cattle, sheep, and goats, characterized by blepharospasm, lacrimation, conjunctivitis, and varying degrees of corneal opacity and ulceration. In cattle the causative agent is MORAXELLA (MORAXELLA) BOVIS; in sheep, MYCOPLASMA; RICKETTSIA; CHLAMYDIA; or ACHOLEPLASMA; in goats, RICKETTSIA.	""	0	#FFFFFF
D007640	C11.204.627	Keratoconus	A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)	""	0	#FFFFFF
D007642	C17.800.428	Keratosis	Any horny growth such as a wart or callus.	""	0	#FFFFFF
D007644	C16.320.850.190|C17.800.428.275|C17.800.827.190	Darier Disease	An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.	""	0	#FFFFFF
D007645	C16.320.850.475|C17.800.428.435|C17.800.827.475	Keratoderma, Palmoplantar	Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).	""	0	#FFFFFF
D007647	C10.228.140.163.480|C15.378.295.502|C16.614.304.502|C18.452.132.480|C20.306.502|C23.550.429.750	Kernicterus	A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)	""	0	#FFFFFF
D007662	C18.452.076.176.652	Ketosis	A condition characterized by an abnormally elevated concentration of KETONE BODIES in the blood (acetonemia) or urine (acetonuria). It is a sign of DIABETES COMPLICATION, starvation, alcoholism or a mitochondrial metabolic disturbance (e.g., MAPLE SYRUP URINE DISEASE).	""	0	#FFFFFF
D007669	C12.050.351.968.419.600.500|C12.050.351.968.967.249.500|C12.050.351.968.967.500.503|C12.200.777.419.600.500|C12.200.777.967.249.500|C12.200.777.967.500.503|C12.950.419.600.500|C12.950.967.249.500|C12.950.967.500.503|C23.300.175.850.550	Kidney Calculi	Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.	""	0	#FFFFFF
D007673	C12.050.351.968.419.393|C12.200.777.419.393|C12.950.419.393	Kidney Cortex Necrosis	Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.	""	0	#FFFFFF
D007674	C12.050.351.968.419|C12.200.777.419|C12.950.419	Kidney Diseases	Pathological processes of the KIDNEY or its component tissues.	""	0	#FFFFFF
D007676	C12.050.351.968.419.780.750.500|C12.200.777.419.780.750.500|C12.950.419.780.750.500|C23.550.291.500.906.500	Kidney Failure, Chronic	The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	""	0	#FFFFFF
D007680	C04.588.945.947.535|C12.050.351.937.820.535|C12.050.351.968.419.473|C12.200.758.820.750|C12.200.777.419.473|C12.900.820.535|C12.950.419.473|C12.950.983.535	Kidney Neoplasms	Tumors or cancers of the KIDNEY.	""	0	#FFFFFF
D007681	C12.050.351.968.419.493|C12.200.777.419.493|C12.950.419.493	Kidney Papillary Necrosis	A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.	""	0	#FFFFFF
D007683	C12.050.351.968.419.780.050.500|C12.200.777.419.780.050.500|C12.950.419.780.050.500	Kidney Tubular Necrosis, Acute	Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.	""	0	#FFFFFF
D007690	C12.050.351.968.419.403.875|C12.200.777.419.403.875|C12.950.419.403.875|C16.131.077.717|C16.320.184.625	Polycystic Kidney Diseases	Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.	""	0	#FFFFFF
D007691	C12.050.351.968.419.403.500|C12.200.777.419.403.500|C12.950.419.403.500	Medullary Sponge Kidney	A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.	""	0	#FFFFFF
D007706	C10.228.140.163.100.540|C10.597.606.360.455.687|C16.320.322.500.687|C16.320.400.525.687|C16.320.565.189.540|C16.320.565.618.590|C17.800.329.968|C18.452.132.100.540|C18.452.648.189.540|C18.452.648.618.590	Menkes Kinky Hair Syndrome	An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)	""	0	#FFFFFF
D007710	C01.150.252.400.310.503	Klebsiella Infections	Infections with bacteria of the genus KLEBSIELLA.	""	0	#FFFFFF
D007713	C12.050.351.875.253.795.500|C12.200.706.316.795.500|C12.800.316.795.500|C16.131.260.830.835.500|C16.131.939.316.795.500|C16.320.180.830.835.500|C19.391.119.795.500|C19.391.482.629	Klinefelter Syndrome	A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).	""	0	#FFFFFF
D007714	C05.116.099.370.535|C05.660.551|C16.131.621.551	Klippel-Feil Syndrome	A syndrome characterised by a low hairline and a shortened neck resulting from a reduced number of vertebrae or the fusion of multiple hemivertebrae into one osseous mass.	""	0	#FFFFFF
D007715	C14.907.077.410	Klippel-Trenaunay-Weber Syndrome	A congenital disorder that is characterized by a triad of capillary malformations (HEMANGIOMA), venous malformations (ARTERIOVENOUS FISTULA), and soft tissue or bony hypertrophy of the limb. This syndrome is caused by mutations in the VG5Q gene which encodes a strong angiogenesis stimulator.	""	0	#FFFFFF
D007718	C26.558.554	Knee Injuries	Injuries to the knee or the knee joint.	""	0	#FFFFFF
D007724	C12.050.351.500.944.815|C12.100.250.944.815	Vulvar Lichen Sclerosus	Atrophy and shriveling of the SKIN of the VULVA that is characterized by the whitish LICHEN SCLEROSUS appearance, inflammation, and PRURITUS.	""	0	#FFFFFF
D007725	C04.557.470.200.025.415.410|C04.557.470.590.415.410	Krukenberg Tumor	Mucocellular carcinoma of the ovary, usually metastatic from the gastrointestinal tract, characterized by areas of mucoid degeneration and the presence of signet-ring-like cells. It accounts for 30%-40% of metastatic cancers to the ovaries and possibly 1%-2% of all malignant ovarian tumors. The lesions may not be discovered until the primary disease is advanced, and most patients die of their disease within a year. In some cases, a primary tumor is not found. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1685)	""	0	#FFFFFF
D007729	C01.207.800.435|C10.228.228.800.435|C10.574.843.625	Kuru	A prion disease found exclusively among the Fore linguistic group natives of the highlands of NEW GUINEA. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773)	""	0	#FFFFFF
D007732	C18.654.521.719.500	Kwashiorkor	"A syndrome produced by severe protein deficiency, characterized by retarded growth, changes in skin and hair pigment, edema, and pathologic changes in the liver, including fatty infiltration, necrosis, and fibrosis. The word is a local name in Gold Coast, Africa, meaning ""displaced child"". Although first reported from Africa, kwashiorkor is now known throughout the world, but mainly in the tropics and subtropics. It is considered to be related to marasmus. (From Dorland, 27th ed)"	""	0	#FFFFFF
D007733	C01.920.930.475|C01.925.081.656|C01.925.782.350.250.635|C01.925.782.417.475	Kyasanur Forest Disease	Tick-borne flavivirus infection occurring in the Kyasanur Forest in India.	""	0	#FFFFFF
D007738	C05.116.900.800.500	Kyphosis	Deformities of the SPINE characterized by an exaggerated convexity of the vertebral column. The forward bending of the thoracic region usually is more than 40 degrees. This deformity sometimes is called round back or hunchback.	""	0	#FFFFFF
D007744	C12.050.703.420	Obstetric Labor Complications	Medical problems associated with OBSTETRIC LABOR, such as BREECH PRESENTATION; PREMATURE OBSTETRIC LABOR; HEMORRHAGE; or others. These complications can affect the well-being of the mother, the FETUS, or both.	""	0	#FFFFFF
D007752	C12.050.703.420.491	Obstetric Labor, Premature	Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE).	""	0	#FFFFFF
D007757	C01.503|C24.506	Laboratory Infection	Accidentally acquired infection in laboratory workers.	""	0	#FFFFFF
D007759	C09.218.568	Labyrinth Diseases	Pathological processes of the inner ear (LABYRINTH) which contains the essential apparatus of hearing (COCHLEA) and balance (SEMICIRCULAR CANALS).	""	0	#FFFFFF
D007762	C09.218.568.558|C09.218.705.371	Labyrinthitis	Inflammation of the inner ear (LABYRINTH).	""	0	#FFFFFF
D007766	C11.496	Lacrimal Apparatus Diseases	Diseases of the LACRIMAL APPARATUS.	""	0	#FFFFFF
D007767	C11.496.456	Lacrimal Duct Obstruction	Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)	""	0	#FFFFFF
D007775	C12.050.703.844.506|C17.800.090.937	Lactation Disorders	Disturbances of MILK secretion in either SEX, not necessarily related to PREGNANCY.	""	0	#FFFFFF
D007787	C06.405.469.637.506|C16.320.565.202.589|C18.452.603.506|C18.452.648.202.589	Lactose Intolerance	The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.	""	0	#FFFFFF
D007794	C22.510	Lameness, Animal	A departure from the normal gait in animals.	""	0	#FFFFFF
D007805	C10.597.606.150.500.550|C23.888.592.604.150.500.550	Language Development Disorders	Conditions characterized by language abilities (comprehension and expression of speech and writing) that are below the expected level for a given age, generally in the absence of an intellectual impairment. These conditions may be associated with DEAFNESS; BRAIN DISEASES; MENTAL DISORDERS; or environmental factors.	""	0	#FFFFFF
D007806	C10.597.606.150.500|C23.888.592.604.150.500	Language Disorders	Conditions characterized by deficiencies of comprehension or expression of written and spoken forms of language. These include acquired and developmental disorders.	""	0	#FFFFFF
D007815	C01.610.335.508.523|C01.610.858.424|C17.800.838.775.424	Larva Migrans	Infections caused by nematode larvae which never develop into the adult stage and migrate through various body tissues. They commonly infect the skin, eyes, and viscera in man. Ancylostoma brasiliensis causes cutaneous larva migrans. Toxocara causes visceral larva migrans.	""	0	#FFFFFF
D007816	C01.610.335.508.523.780|C01.610.335.508.700.100.868.420	Larva Migrans, Visceral	A condition produced in man by the prolonged migration of animal nematode larvae in extraintestinal tissues other than skin; characterized by persistent hypereosinophilia, hepatomegaly, and frequently pneumonitis, commonly caused by Toxocara canis and Toxocara cati.	""	0	#FFFFFF
D007818	C08.360|C09.400	Laryngeal Diseases	Pathological processes involving any part of the LARYNX which coordinates many functions such as voice production, breathing, swallowing, and coughing.	""	0	#FFFFFF
D007819	C08.360.313|C09.400.313	Laryngeal Edema	Abnormal accumulation of fluid in tissues of any part of the LARYNX, commonly associated with laryngeal injuries and allergic reactions.	""	0	#FFFFFF
D007822	C04.588.443.665.481|C08.360.369|C08.785.481|C09.400.369|C09.647.481	Laryngeal Neoplasms	Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.	""	0	#FFFFFF
D007826	C08.360.895.500|C08.618.980.500|C09.400.895.500	Laryngismus	A disorder in which the adductor muscles of the VOCAL CORDS exhibit increased activity leading to laryngeal spasm. Laryngismus causes closure of the VOCAL FOLDS and airflow obstruction during inspiration.	""	0	#FFFFFF
D007827	C01.748.368|C08.360.535|C08.730.368|C09.400.535	Laryngitis	Inflammation of the LARYNGEAL MUCOSA, including the VOCAL CORDS. Laryngitis is characterized by irritation, edema, and reduced pliability of the mucosa leading to VOICE DISORDERS such as APHONIA and HOARSENESS.	""	0	#FFFFFF
D007829	C08.360.591|C09.400.591|C16.131.740.658	Laryngostenosis	Developmental or acquired stricture or narrowing of the LARYNX. Symptoms of respiratory difficulty depend on the degree of laryngeal narrowing.	""	0	#FFFFFF
D007835	C01.925.782.082.545|C01.925.782.417.505	Lassa Fever	An acute febrile human disease caused by the LASSA VIRUS.	""	0	#FFFFFF
D007842	C25.723.756.558	Lathyrism	A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS.	""	0	#FFFFFF
D007849	C10.228.140.617.500|C16.131.077.509	Laurence-Moon Syndrome	An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)	""	0	#FFFFFF
D007855	C25.723.522.750	Lead Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	""	0	#FFFFFF
D007859	C10.597.606.150.550|C23.888.592.604.150.550	Learning Disabilities	Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.	""	0	#FFFFFF
D007863	C16.320.565.398.500.330.500|C18.452.584.500.875.330.500|C18.452.584.563.500.330.500|C18.452.648.398.500.330.500	Lecithin Cholesterol Acyltransferase Deficiency	An autosomal recessive disorder of lipoprotein metabolism caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE gene. It is characterized by low HDL-cholesterol levels, and the triad of CORNEAL OPACITIES; HEMOLYTIC ANEMIA; and PROTEINURIA with renal failure.	""	0	#FFFFFF
D007868	C17.800.446	Leg Dermatoses	A nonspecific term used to denote any cutaneous lesion or group of lesions, or eruptions of any type on the leg. (From Stedman, 25th ed)	""	0	#FFFFFF
D007869	C26.558	Leg Injuries	General or unspecified injuries involving the leg.	""	0	#FFFFFF
D007870	C05.116.099.655|C23.300.808	Leg Length Inequality	A condition in which one of a pair of legs fails to grow as long as the other, which could result from injury or surgery.	""	0	#FFFFFF
D007871	C17.800.893.592	Leg Ulcer	Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.	""	0	#FFFFFF
D007873	C05.116.852.175.570	Legg-Calve-Perthes Disease	A particular type of FEMUR HEAD NECROSIS occurring in children, mainly male, with a course of four years or so.	""	0	#FFFFFF
D007876	C01.150.252.400.500|C01.748.382|C08.730.382	Legionellosis	Infections with bacteria of the genus LEGIONELLA.	""	0	#FFFFFF
D007877	C01.150.252.400.500.501|C01.748.382.380|C08.730.382.380	Legionnaires' Disease	An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.	""	0	#FFFFFF
D007888	C10.228.140.163.100.412|C16.320.565.189.412|C16.320.565.202.810.444|C18.452.132.100.412|C18.452.648.189.412|C18.452.648.202.810.444|C18.452.660.520	Leigh Disease	A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).	""	0	#FFFFFF
D007889	C04.557.450.590.450	Leiomyoma	A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.	""	0	#FFFFFF
D007890	C04.557.450.590.455|C04.557.450.795.455	Leiomyosarcoma	A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)	""	0	#FFFFFF
D007896	C01.610.752.300.500|C01.610.858.560|C01.920.813|C17.800.838.775.560	Leishmaniasis	A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).	""	0	#FFFFFF
D007897	C01.610.752.300.500.400.385|C01.610.858.560.400.385|C01.920.813.400.385|C17.800.838.775.560.400.385	Leishmaniasis, Mucocutaneous	A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.	""	0	#FFFFFF
D007898	C01.610.752.300.500.510|C01.920.813.510	Leishmaniasis, Visceral	A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.	""	0	#FFFFFF
D007905	C11.510	Lens Diseases	Diseases involving the CRYSTALLINE LENS.	""	0	#FFFFFF
D007906	C11.510.598	Lens Subluxation	Incomplete rupture of the zonule with the displaced lens remaining behind the pupil. In dislocation, or complete rupture, the lens is displaced forward into the anterior chamber or backward into the vitreous body. When congenital, this condition is known as ECTOPIA LENTIS.	""	0	#FFFFFF
D007911	C17.800.621.430.530.550	Lentigo	Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).	""	0	#FFFFFF
D007918	C01.150.252.410.040.552.475.371	Leprosy	A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.	""	0	#FFFFFF
D007922	C01.150.252.400.794.511	Leptospirosis	Infections with bacteria of the genus LEPTOSPIRA.	""	0	#FFFFFF
D007925	C14.907.109.661|C14.907.137.427	Leriche Syndrome	A condition caused by occlusion of terminal aorta, the primary branches of the ABDOMINAL AORTA, as in aortoiliac obstruction. Leriche syndrome usually occurs in males and is characterized by IMPOTENCE, absence of a pulse in the femoral arteries, weakness and numbness in the lower back, buttocks, hips, and lower limbs.	""	0	#FFFFFF
D007926	C10.228.140.163.100.425|C10.597.606.360.455.625|C16.320.322.500.625|C16.320.400.525.625|C16.320.565.189.425|C16.320.565.798.594|C18.452.132.100.425|C18.452.648.189.425|C18.452.648.798.594	Lesch-Nyhan Syndrome	An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)	""	0	#FFFFFF
D007938	C04.557.337	Leukemia	A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	""	0	#FFFFFF
D007939	C04.557.337.372.594|C04.619.531.594	Leukemia L1210	An experimental LYMPHOCYTIC LEUKEMIA of mice.	""	0	#FFFFFF
D007940	C04.557.337.372.602|C04.619.531.602	Leukemia L5178	An experimental lymphocytic leukemia of mice.	""	0	#FFFFFF
D007941	C04.557.337.372.782|C04.619.531.782	Leukemia P388	An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	""	0	#FFFFFF
D007942	C04.557.337.372|C04.619.531	Leukemia, Experimental	Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.	""	0	#FFFFFF
D007943	C04.557.337.415|C15.604.515.553|C20.683.515.517	Leukemia, Hairy Cell	"A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of ""hairy"" or ""flagellated"" cells in the blood and bone marrow."	""	0	#FFFFFF
D007945	C04.557.337.428|C15.604.515.560|C20.683.515.528	Leukemia, Lymphoid	Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	""	0	#FFFFFF
D007946	C04.557.337.440|C04.557.337.539.275.440|C20.762.750.750.500	Leukemia, Mast-Cell	A form of systemic mastocytosis (MASTOCYTOSIS, SYSTEMIC) characterized by the presence of large numbers of tissue MAST CELLS in the peripheral blood without skin lesions. It is a high-grade LEUKEMIA disease with bone marrow smear of >20% MAST CELLS, multi-organ failure and a short survival.	""	0	#FFFFFF
D007947	C04.557.337.539.275.450	Leukemia, Megakaryoblastic, Acute	An acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. MYELOFIBROSIS or increased bone marrow RETICULIN is common.	""	0	#FFFFFF
D007948	C04.557.337.539.275.484	Leukemia, Monocytic, Acute	An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.	""	0	#FFFFFF
D007951	C04.557.337.539	Leukemia, Myeloid	Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.	""	0	#FFFFFF
D007952	C04.557.337.595|C04.557.595.500.500|C20.683.515.845.500	Leukemia, Plasma Cell	A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.	""	0	#FFFFFF
D007953	C04.557.337.650|C04.682.512|C26.733.345	Leukemia, Radiation-Induced	Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.	""	0	#FFFFFF
D007955	C15.378.190.636.484|C15.378.553.475.428	Leukemoid Reaction	A peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone. (Dorland, 27th ed)	""	0	#FFFFFF
D007960	C15.378.553	Leukocyte Disorders	Disordered formation of various types of leukocytes or an abnormal accumulation or deficiency of these cells.	""	0	#FFFFFF
D007964	C15.378.553.475|C23.550.526	Leukocytosis	A transient increase in the number of leukocytes in a body fluid.	""	0	#FFFFFF
D007965	C10.228.140.163.100.362.500|C10.228.140.163.100.435.825.590|C10.228.140.695.625.500|C10.314.400.500|C16.320.565.189.362.500|C16.320.565.189.435.825.590|C16.320.565.398.641.803.585|C16.320.565.595.554.825.590|C18.452.132.100.362.500|C18.452.132.100.435.825.590|C18.452.584.563.641.803.585|C18.452.648.189.362.500|C18.452.648.189.435.825.590|C18.452.648.398.641.803.585|C18.452.648.595.554.825.590	Leukodystrophy, Globoid Cell	An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.	""	0	#FFFFFF
D007966	C10.228.140.163.100.362.550|C10.228.140.163.100.435.825.850.500|C10.228.140.695.625.550|C10.314.400.550|C16.320.565.189.362.550|C16.320.565.189.435.825.850.500|C16.320.565.398.641.803.925.500|C16.320.565.595.554.825.850.500|C18.452.132.100.362.550|C18.452.132.100.435.825.850.500|C18.452.584.563.641.803.925.500|C18.452.648.189.362.550|C18.452.648.189.435.825.850.500|C18.452.648.398.641.803.925.500|C18.452.648.595.554.825.850.500	Leukodystrophy, Metachromatic	An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.	""	0	#FFFFFF
D007967	C07.465.385	Leukoedema, Oral	A disorder of the buccal mucosa resembling early leukoplakia, characterized by the presence of filmy opalescence of the mucosa in the early stages to a whitish gray cast with a coarsely wrinkled surface in the later stages, associated with intracellular edema of the spinous or malpighian layer. (Dorland, 27th ed)	""	0	#FFFFFF
D007968	C01.207.245.340.500|C01.207.399.750.500|C01.925.182.525.500|C01.925.256.721.500|C01.925.839.550|C10.228.140.430.520.750.500|C10.228.140.695.750|C10.228.228.245.340.500|C10.228.228.399.750.500|C10.314.450|C10.586.250.520.750.500	Leukoencephalopathy, Progressive Multifocal	An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)	""	0	#FFFFFF
D007969	C10.228.140.300.700|C10.228.140.461.550|C14.907.253.612|C16.614.521.450	Leukomalacia, Periventricular	Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)	""	0	#FFFFFF
D007970	C15.378.553.546	Leukopenia	A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).	""	0	#FFFFFF
D007971	C04.834.512|C23.300.816	Leukoplakia	A white patch lesion found on a MUCOUS MEMBRANE that cannot be scraped off. Leukoplakia is generally considered a precancerous condition, however its appearance may also result from a variety of HEREDITARY DISEASES.	""	0	#FFFFFF
D007972	C04.588.443.591.545|C04.834.512.513|C07.465.530.545|C23.300.816.513	Leukoplakia, Oral	A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY).	""	0	#FFFFFF
D007973	C12.050.351.500.894.700.500|C12.100.250.894.700.500	Leukorrhea	A clear or white discharge from the VAGINA, consisting mainly of MUCUS.	""	0	#FFFFFF
D007979	C14.240.400.701|C14.280.400.701|C16.131.240.400.701|C16.131.810.700	Levocardia	Congenital abnormalities in which the HEART is in the normal position (levocardia) in the left side of the chest but some or all of the THORAX or ABDOMEN viscera are transposed laterally (SITUS INVERSUS). It is also known as situs inversus with levocardia, or isolated levocardia. This condition is often associated with severe heart defects and splenic abnormalities such as asplenia or polysplenia.	""	0	#FFFFFF
D007984	C04.557.475.750.847.249|C04.588.322.762.500.249|C04.588.945.440.915.500.249|C12.100.500.260.937.500.249|C12.200.294.260.937.500.249|C12.200.758.409.937.500.249|C12.900.619.937.500.249|C19.344.762.500.249|C19.391.829.782.500.249	Leydig Cell Tumor	Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.	""	0	#FFFFFF
D008010	C17.800.859.475.560	Lichen Planus	"An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a ""saw-tooth"" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown."	""	0	#FFFFFF
D008039	C04.557.470.200.025.095.410	Linitis Plastica	"A condition where the stomach wall becomes thickened, rubbery and loses its ability to distend. The stomach assumes a ""leather bottle"" shape. It is most often seen in adenocarcinoma of the stomach. The term is often used synonymously with diffuse adenocarcinoma of the stomach."	""	0	#FFFFFF
D008047	C07.465.409	Lip Diseases	Diseases involving the LIP.	""	0	#FFFFFF
D008048	C04.588.443.591.550|C07.465.409.640|C07.465.530.550	Lip Neoplasms	Tumors or cancer of the LIP.	""	0	#FFFFFF
D008052	C16.320.565.398|C18.452.584.563|C18.452.648.398	Lipid Metabolism, Inborn Errors	Errors in the metabolism of LIPIDS resulting from inborn genetic MUTATIONS that are heritable.	""	0	#FFFFFF
D008059	C16.320.565.202.715.640|C16.320.565.595.600.640|C17.300.550.575.640|C18.452.648.202.715.640|C18.452.648.595.600.640	Mucopolysaccharidosis I	Systemic lysosomal storage disease caused by a deficiency of alpha-L-iduronidase (IDURONIDASE) and characterized by progressive physical deterioration with urinary excretion of DERMATAN SULFATE and HEPARAN SULFATE. There are three recognized phenotypes representing a spectrum of clinical severity from severe to mild: Hurler syndrome, Hurler-Scheie syndrome and Scheie syndrome (formerly mucopolysaccharidosis V). Symptoms may include DWARFISM; hepatosplenomegaly; thick, coarse facial features with low nasal bridge; corneal clouding; cardiac complications; and noisy breathing.	""	0	#FFFFFF
D008060	C17.800.849.391|C18.452.584.625|C18.452.880.391	Lipodystrophy	A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.	""	0	#FFFFFF
D008061	C01.150.252.410.040.137.631|C06.405.469.637.925|C18.452.603.925	Whipple Disease	A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.	""	0	#FFFFFF
D008064	C16.320.565.398.641|C18.452.584.563.641|C18.452.648.398.641	Lipidoses	Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.	""	0	#FFFFFF
D008065	C08.618.490.500|C16.320.850.595	Lipoid Proteinosis of Urbach and Wiethe	An autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of SKIN; MUCOSA; and certain VISCERA. This disorder is caused by mutation in the extracellular matrix protein 1 gene (ECM1). Clinical features include hoarseness and skin eruption due to widespread deposition of HYALIN.	""	0	#FFFFFF
D008067	C04.557.450.550.400	Lipoma	A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.	""	0	#FFFFFF
D008068	C17.800.463|C18.452.584.718	Lipomatosis	A disorder characterized by the accumulation of encapsulated or unencapsulated tumor-like fatty tissue resembling LIPOMA.	""	0	#FFFFFF
D008069	C17.800.463.500|C18.452.584.718.750	Lipomatosis, Multiple Symmetrical	A condition characterized by the growth of unencapsulated masses of ADIPOSE TISSUE symmetrically deposited around the neck, shoulders, or other sites around the body.	""	0	#FFFFFF
D008072	C16.320.565.398.465|C18.452.584.500.500.644.237|C18.452.584.563.465|C18.452.648.398.465	Hyperlipoproteinemia Type I	An inherited condition due to a deficiency of either LIPOPROTEIN LIPASE or APOLIPOPROTEIN C-II (a lipase-activating protein). The lack of lipase activities results in inability to remove CHYLOMICRONS and TRIGLYCERIDES from the blood which has a creamy top layer after standing.	""	0	#FFFFFF
D008080	C04.557.450.550.420|C04.557.450.795.465	Liposarcoma	A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)	""	0	#FFFFFF
D008088	C01.150.252.410.514	Listeriosis	Infections with bacteria of the genus LISTERIA.	""	0	#FFFFFF
D008100	C01.830.025.020.455|C06.552.597	Liver Abscess	Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.	""	0	#FFFFFF
D008101	C01.610.518.600|C01.610.752.049.703|C01.830.025.020.455.460|C06.552.597.517|C06.552.664.642	Liver Abscess, Amebic	Single or multiple areas of PUS due to infection by any ameboid protozoa (AMEBIASIS). A common form is caused by the ingestion of ENTAMOEBA HISTOLYTICA.	""	0	#FFFFFF
D008103	C06.552.630|C23.550.355.412	Liver Cirrhosis	Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.	""	0	#FFFFFF
D008104	C06.552.630.380|C06.552.645.590|C23.550.355.412.380|C25.775.100.087.645.550	Liver Cirrhosis, Alcoholic	FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.	""	0	#FFFFFF
D008105	C06.130.120.135.250.250|C06.552.150.250|C06.552.630.400|C23.550.355.412.400	Liver Cirrhosis, Biliary	FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.	""	0	#FFFFFF
D008106	C06.552.630.467|C23.550.355.412.467	Liver Cirrhosis, Experimental	Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.	""	0	#FFFFFF
D008107	C06.552	Liver Diseases	Pathological processes of the LIVER.	""	0	#FFFFFF
D008108	C06.552.645|C25.775.100.087.645	Liver Diseases, Alcoholic	Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.	""	0	#FFFFFF
D008109	C01.610.518|C06.552.664	Liver Diseases, Parasitic	Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).	""	0	#FFFFFF
D008113	C04.588.274.623|C06.301.623|C06.552.697	Liver Neoplasms	Tumors or cancer of the LIVER.	""	0	#FFFFFF
D008114	C04.588.274.623.460|C04.619.540|C06.301.623.460|C06.552.697.580	Liver Neoplasms, Experimental	Experimentally induced tumors of the LIVER.	""	0	#FFFFFF
D008118	C01.610.335.508.700.750.361.518	Loiasis	A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.	""	0	#FFFFFF
D008133	C14.280.067.565|C14.280.123.625|C16.131.240.400.715|C23.550.073.547	Long QT Syndrome	A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.	""	0	#FFFFFF
D008141	C05.116.900.800.750	Lordosis	The anterior concavity in the curvature of the lumbar and cervical spine as viewed from the side. The term usually refers to abnormally increased curvature (hollow back, saddle back, swayback). It does not include lordosis as normal mating posture in certain animals ( = POSTURE + SEX BEHAVIOR, ANIMAL).	""	0	#FFFFFF
D008146	C01.925.782.350.250.650|C22.836.435	Louping Ill	An acute tick-borne arbovirus infection causing meningoencephalomyelitis of sheep.	""	0	#FFFFFF
D008151	C14.280.067.780.560|C14.280.123.750.560	Lown-Ganong-Levine Syndrome	A form of ventricular pre-excitation characterized by a short PR interval and a normal QRS complex. In this syndrome, the atrial impulse conducts via the JAMES FIBERS which connect the atrium to BUNDLE OF HIS bypassing the upper ATRIOVENTRICULAR NODE. HEART VENTRICLES are depolarized normally through the His-Purkinje system.	""	0	#FFFFFF
D008158	C01.800.130.500|C07.465.433	Ludwig's Angina	Severe cellulitis of the submaxillary space with secondary involvement of the perimandibular spaces. It usually results from infection in the lower molar area or from an infection following a penetrating injury to the MOUTH FLOOR.	""	0	#FFFFFF
D008166	C01.925.256.743.494|C22.196.497	Lumpy Skin Disease	A poxvirus infection of cattle characterized by the appearance of nodules on all parts of the skin.	""	0	#FFFFFF
D008169	C01.748.407|C01.830.025.490|C08.381.450|C08.730.407	Lung Abscess	Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.	""	0	#FFFFFF
D008171	C08.381	Lung Diseases	Pathological processes involving any part of the LUNG.	""	0	#FFFFFF
D008172	C01.150.703.534|C01.748.435|C08.381.472|C08.730.435	Lung Diseases, Fungal	Pulmonary diseases caused by fungal infections, usually through hematogenous spread.	""	0	#FFFFFF
D008173	C08.381.495	Lung Diseases, Obstructive	Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.	""	0	#FFFFFF
D008174	C01.610.582|C01.748.450|C08.381.517|C08.730.450	Lung Diseases, Parasitic	Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).	""	0	#FFFFFF
D008175	C04.588.894.797.520|C08.381.540|C08.785.520	Lung Neoplasms	Tumors or cancer of the LUNG.	""	0	#FFFFFF
D008177	C01.150.252.819.820.470|C01.800.720.820.470|C17.800.838.765.820.470	Lupus Vulgaris	A form of cutaneous tuberculosis. It is seen predominantly in women and typically involves the NASAL MUCOSA; BUCCAL MUCOSA; and conjunctival mucosa.	""	0	#FFFFFF
D008178	C17.300.475|C17.800.480	Lupus Erythematosus, Cutaneous	A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).	""	0	#FFFFFF
D008179	C17.300.475.479|C17.800.480.479	Lupus Erythematosus, Discoid	A chronic form of cutaneous lupus erythematosus (LUPUS ERYTHEMATOSUS, CUTANEOUS) in which the skin lesions mimic those of the systemic form but in which systemic signs are rare. It is characterized by the presence of discoid skin plaques showing varying degrees of edema, erythema, scaliness, follicular plugging, and skin atrophy. Lesions are surrounded by an elevated erythematous border. The condition typically involves the face and scalp, but widespread dissemination may occur.	""	0	#FFFFFF
D008180	C17.300.480|C20.111.590	Lupus Erythematosus, Systemic	A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.	""	0	#FFFFFF
D008181	C12.050.351.968.419.570.363.680|C12.200.777.419.570.363.680|C12.950.419.570.363.680|C17.300.480.680|C20.111.590.560	Lupus Nephritis	Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).	""	0	#FFFFFF
D008185	C14.240.400.560.375.518|C14.280.400.560.375.518|C16.131.240.400.560.375.518	Lutembacher Syndrome	A condition characterized by a combination of OSTIUM SECUNDUM ATRIAL SEPTAL DEFECT and an acquired MITRAL VALVE STENOSIS.	""	0	#FFFFFF
D008193	C01.150.252.400.536|C01.150.252.400.794.352.250|C01.920.930.513	Lyme Disease	An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.	""	0	#FFFFFF
D008199	C15.604.315	Lymphadenitis	Inflammation of the lymph nodes.	""	0	#FFFFFF
D008200	C15.604.360	Lymphangiectasis	A transient dilatation of the lymphatic vessels.	""	0	#FFFFFF
D008201	C15.604.360.500|C15.604.451.500|C16.131.482.500	Lymphangiectasis, Intestinal	Dilatation of the intestinal lymphatic system usually caused by an obstruction in the intestinal wall. It may be congenital or acquired and is characterized by DIARRHEA; HYPOPROTEINEMIA; peripheral and/or abdominal EDEMA; and PROTEIN-LOSING ENTEROPATHIES.	""	0	#FFFFFF
D008202	C04.557.375.450	Lymphangioma	A benign tumor resulting from a congenital malformation of the lymphatic system. Lymphangioendothelioma is a type of lymphangioma in which endothelial cells are the dominant component.	""	0	#FFFFFF
D008203	C04.557.375.460|C15.604.515.562|C20.683.515.710	Lymphangiomyoma	A tumorlike condition characterized by SMOOTH MUSCLE and ENDOTHELIUM proliferation of LYMPHATIC VESSELS and LYMPH NODES in the MEDIASTINUM and retroperitoneum, also in the lung. It may be manifested by chylous PLEURAL EFFUSION and ASCITES.	""	0	#FFFFFF
D008204	C04.557.375.480|C04.557.450.795.480	Lymphangiosarcoma	A malignant tumor originating from the endothelial cells of lymphatic vessels. Most lymphangiosarcomas arise in an arm secondary to radical mastectomy but they sometimes complicate idiopathic lymphedema. The lymphedema has usually been present for 6 to 10 years before malignant changes develop. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)	""	0	#FFFFFF
D008205	C15.604.406	Lymphangitis	A lymphatic disease characterized by INFLAMMATION of LYMPHATIC VESSELS.	""	0	#FFFFFF
D008206	C15.604	Lymphatic Diseases	Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.	""	0	#FFFFFF
D008207	C04.697.650.560|C23.550.727.650.560	Lymphatic Metastasis	Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.	""	0	#FFFFFF
D008209	C15.604.496	Lymphedema	Edema due to obstruction of lymph vessels or disorders of the lymph nodes.	""	0	#FFFFFF
D008210	C04.182.430|C15.604.510	Lymphocele	Cystic mass containing lymph from diseased lymphatic channels or following surgical trauma or other injury.	""	0	#FFFFFF
D008216	C01.207.245.500.500|C01.925.182.550.500|C01.925.782.082.580|C10.228.228.245.500.500|C10.586.625.400.500	Lymphocytic Choriomeningitis	A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)	""	0	#FFFFFF
D008218	C15.378.553.475.604	Lymphocytosis	Excess of normal lymphocytes in the blood or in any effusion.	""	0	#FFFFFF
D008219	C01.150.252.400.210.125.490|C01.150.252.734.301.490|C01.221.812.281.301.490|C01.778.281.301.490|C12.100.937.281.301.490	Lymphogranuloma Venereum	Subacute inflammation of the inguinal lymph glands caused by certain immunotypes of CHLAMYDIA TRACHOMATIS. It is a sexually transmitted disease in the U.S. but is more widespread in developing countries. It is distinguished from granuloma venereum (see GRANULOMA INGUINALE), which is caused by Calymmatobacterium granulomatis.	""	0	#FFFFFF
D008223	C04.557.386|C15.604.515.569|C20.683.515.761	Lymphoma	A general term for various neoplastic diseases of the lymphoid tissue.	""	0	#FFFFFF
D008224	C04.557.386.480.350|C15.604.515.569.480.350|C20.683.515.761.480.350	Lymphoma, Follicular	Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.	""	0	#FFFFFF
D008228	C04.557.386.480|C15.604.515.569.480|C20.683.515.761.480	Lymphoma, Non-Hodgkin	Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.	""	0	#FFFFFF
D008230	C04.557.386.480.150.600|C04.834.567|C15.604.515.569.480.150.600|C20.683.515.761.480.150.600	Lymphomatoid Granulomatosis	An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.	""	0	#FFFFFF
D008231	C15.378.553.546.605|C20.673.627	Lymphopenia	Reduction in the number of lymphocytes.	""	0	#FFFFFF
D008232	C15.604.515|C20.683.515	Lymphoproliferative Disorders	Disorders characterized by proliferation of lymphoid tissue, general or unspecified.	""	0	#FFFFFF
D008258	C04.557.595.925|C14.907.454.960|C15.378.147.780.925|C15.378.463.515.960|C15.604.515.925|C20.683.780.925	Waldenstrom Macroglobulinemia	A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.	""	0	#FFFFFF
D008260	C07.465.910.460	Macroglossia	The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)	""	0	#FFFFFF
D008265	C07.465.525.480|C07.650.525.480|C16.131.850.525.480	Macrostomia	Greatly exaggerated width of the mouth, resulting from failure of union of the maxillary and mandibular processes, with extension of the oral orifice toward the ear. The defect may be unilateral or bilateral. (Dorland, 27th ed)	""	0	#FFFFFF
D008268	C11.768.585.439	Macular Degeneration	Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.	""	0	#FFFFFF
D008269	C11.768.585.439.245	Macular Edema	Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)	""	0	#FFFFFF
D008271	C01.150.252.410.040.692.500|C01.150.252.819.557|C01.150.703.302.500|C01.800.200.500|C01.800.720.557|C17.800.838.208.557|C17.800.838.765.557	Mycetoma	A chronic progressive subcutaneous infection caused by species of fungi (eumycetoma), or actinomycetes (actinomycetoma). It is characterized by tumefaction, abscesses, and tumor-like granules representing microcolonies of pathogens, such as MADURELLA fungi and bacteria ACTINOMYCETES, with different grain colors.	""	0	#FFFFFF
D008275	C18.654.521.500.439	Magnesium Deficiency	A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)	""	0	#FFFFFF
D008286	C06.405.469.637|C18.452.603	Malabsorption Syndromes	General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.	""	0	#FFFFFF
D008287	C23.550.548	Malacoplakia	The formation of soft patches on the mucous membrane of a hollow organ, such as the urogenital tract or digestive tract.	""	0	#FFFFFF
D008288	C01.610.752.530|C01.920.875	Malaria	A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	""	0	#FFFFFF
D008289	C01.610.752.530.606|C01.920.875.606|C22.131.498	Malaria, Avian	Any of a group of infections of fowl caused by protozoa of the genera PLASMODIUM, Leucocytozoon, and Haemoproteus. The life cycles of these parasites and the disease produced bears strong resemblance to those observed in human malaria.	""	0	#FFFFFF
D008303	C04.557.465.625.650.200.500|C04.557.470.200.025.200.500|C04.557.580.625.650.200.500	Malignant Carcinoid Syndrome	A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)	""	0	#FFFFFF
D008304	C01.925.256.466.606|C22.196.540	Malignant Catarrh	A herpesvirus infection of cattle characterized by catarrhal inflammation of the upper respiratory and alimentary epithelia, keratoconjunctivitis, encephalitis and lymph node enlargement. Syn: bovine epitheliosis, snotsiekte.	""	0	#FFFFFF
D008305	C23.550.505.700|C23.550.767.600	Malignant Hyperthermia	Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.	""	0	#FFFFFF
D008309	C06.405.117.468.524	Mallory-Weiss Syndrome	A condition characterized by mucosal tears at the ESOPHAGOGASTRIC JUNCTION, sometimes with HEMATEMESIS. Typically it is caused by forceful bouts of retching or VOMITING.	""	0	#FFFFFF
D008310	C07.793.494	Malocclusion	Such malposition and contact of the maxillary and mandibular teeth as to interfere with the highest efficiency during the excursive movements of the jaw that are essential for mastication. (Jablonski, Illustrated Dictionary of Dentistry, 1982)	""	0	#FFFFFF
D008311	C07.793.494.610	Malocclusion, Angle Class I	Malocclusion in which the mandible and maxilla are anteroposteriorly normal as reflected by the relationship of the first permanent molar (i.e., in neutroclusion), but in which individual teeth are abnormally related to each other.	""	0	#FFFFFF
D008312	C07.793.494.630	Malocclusion, Angle Class II	Malocclusion in which the mandible is posterior to the maxilla as reflected by the relationship of the first permanent molar (distoclusion).	""	0	#FFFFFF
D008313	C07.793.494.650	Malocclusion, Angle Class III	Malocclusion in which the mandible is anterior to the maxilla as reflected by the first relationship of the first permanent molar (mesioclusion).	""	0	#FFFFFF
D008325	C04.588.531.500|C04.619.590	Mammary Neoplasms, Experimental	Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.	""	0	#FFFFFF
D008336	C05.500.607|C07.320.610	Mandibular Diseases	Diseases involving the MANDIBLE.	""	0	#FFFFFF
D008337	C10.900.300.284.500.400.255|C26.404.750.467.441|C26.915.300.425.500.400.255	Mandibular Fractures	Fractures of the lower jaw.	""	0	#FFFFFF
D008338	C10.900.300.284.500.500|C26.915.300.425.500.500	Mandibular Injuries	Injuries to the lower jaw bone.	""	0	#FFFFFF
D008339	C04.588.149.721.450.583|C05.116.231.754.450.583|C05.500.499.583|C05.500.607.442|C07.320.515.583|C07.320.610.583	Mandibular Neoplasms	Tumors or cancer of the MANDIBLE.	""	0	#FFFFFF
D008342	C05.116.099.370.231.576|C05.660.207.231.576|C11.270.147.750|C16.131.621.207.231.576	Mandibulofacial Dysostosis	A hereditary disorder occurring in two forms: the complete form (Franceschetti's syndrome) is characterized by antimongoloid slant of the palpebral fissures, COLOBOMA of the lower lid, MICROGNATHIA and hypoplasia of the ZYGOMATIC ARCHES, and CONGENITAL MICROTIA. It is transmitted as an autosomal trait. The incomplete form (Treacher Collins syndrome) is characterized by the same anomalies in less pronounced degree. It occurs sporadically, but an autosomal dominant mode of transmission is suspected. (Dorland, 27th ed)	""	0	#FFFFFF
D008363	C16.320.565.202.607.500|C16.320.565.595.577.500|C18.452.648.202.607.500|C18.452.648.595.577.500	alpha-Mannosidosis	An inborn error of metabolism marked by a defect in the lysosomal isoform of ALPHA-MANNOSIDASE activity that results in lysosomal accumulation of mannose-rich intermediate metabolites. Virtually all patients have psychomotor retardation, facial coarsening, and some degree of dysostosis multiplex. It is thought to be an autosomal recessive disorder.	""	0	#FFFFFF
D008368	C01.610.335.508.700.750.361.588	Mansonelliasis	Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.	""	0	#FFFFFF
D008375	C10.228.140.163.100.520|C16.320.565.100.608|C16.320.565.189.520|C18.452.132.100.520|C18.452.648.100.608|C18.452.648.189.520	Maple Syrup Urine Disease	"An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain amino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a ""maple syrup"" odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)"	""	0	#FFFFFF
D008379	C01.925.782.417.560|C01.925.782.580.250.500|C22.735.500.500	Marburg Virus Disease	An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.	""	0	#FFFFFF
D008380	C01.925.256.466.650|C01.925.928.489|C15.604.515.700|C20.683.515.840|C22.131.546	Marek Disease	A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.	""	0	#FFFFFF
D008382	C05.116.099.674|C14.240.400.725|C14.280.400.725|C16.131.077.550|C16.131.240.400.720|C16.320.540|C17.300.500	Marfan Syndrome	An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome (type 1) is associated with mutations in the gene encoding FIBRILLIN-1 (FBN1), a major element of extracellular microfibrils of connective tissue.  Mutations in the gene encoding TYPE II TGF-BETA RECEPTOR (TGFBR2) are associated with Marfan syndrome type 2.	""	0	#FFFFFF
D008413	C12.050.703.844.603|C17.800.090.968	Mastitis	INFLAMMATION of the BREAST, or MAMMARY GLAND.	""	0	#FFFFFF
D008414	C22.196.581	Mastitis, Bovine	INFLAMMATION of the UDDER in cows.	""	0	#FFFFFF
D008415	C04.557.450.565.465|C20.762.750	Mastocytosis	A rare neoplastic disorder characterized by a clonal proliferation of MAST CELLS, associated with KIT-D816 mutations, and accompanied by aberrant mast cell activation. The abnormal increase of MAST CELLS may occur in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).	""	0	#FFFFFF
D008417	C01.160.495.500|C05.116.165.495.249|C09.218.705.663.652	Mastoiditis	Inflammation of the honeycomb-like MASTOID BONE in the skull just behind the ear. It is usually a complication of OTITIS MEDIA.	""	0	#FFFFFF
D008439	C05.500.693|C07.320.660	Maxillary Diseases	Diseases involving the MAXILLA.	""	0	#FFFFFF
D008440	C10.900.300.284.500.400.510|C26.404.750.467.611|C26.915.300.425.500.400.510	Maxillary Fractures	Fractures of the upper jaw.	""	0	#FFFFFF
D008441	C04.588.149.721.450.601|C05.116.231.754.450.601|C05.500.499.601|C05.500.693.528|C07.320.515.601|C07.320.660.601	Maxillary Neoplasms	Cancer or tumors of the MAXILLA or upper jaw.	""	0	#FFFFFF
D008444	C04.588.443.665.650.693.575|C08.460.669.693.575|C08.460.692.503.503|C08.785.600.693.575|C09.603.669.693.575|C09.603.692.503.503|C09.647.685.693.575	Maxillary Sinus Neoplasms	Tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.	""	0	#FFFFFF
D008446	C10.900.300.284.500|C26.915.300.425.500	Maxillofacial Injuries	General or unspecified injuries involving the face and jaw (either upper, lower, or both).	""	0	#FFFFFF
D008457	C01.925.782.580.600.500.500	Measles	A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.	""	0	#FFFFFF
D008467	C06.198.859|C06.405.205.282.750.750|C16.131.314.556|C23.300.415.750	Meckel Diverticulum	A congenital abnormality characterized by the outpouching or sac formation in the ILEUM. It is a remnant of the embryonic YOLK SAC in which the VITELLINE DUCT failed to close.	""	0	#FFFFFF
D008471	C08.381.520.687|C08.618.580|C12.050.703.277.785|C16.300.580|C16.614.580	Meconium Aspiration Syndrome	A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.	""	0	#FFFFFF
D008476	C04.182.444|C08.846.187.145	Mediastinal Cyst	Cysts of one of the parts of the mediastinum: the superior part, containing the trachea, esophagus, thoracic duct and thymus organs; the inferior middle part, containing the pericardium; the inferior anterior part containing some lymph nodes; and the inferior posterior part, containing the thoracic duct and esophagus.	""	0	#FFFFFF
D008477	C08.846.187	Mediastinal Diseases	Disorders of the mediastinum, general or unspecified.	""	0	#FFFFFF
D008478	C08.846.187.290|C23.550.325.250	Mediastinal Emphysema	Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.	""	0	#FFFFFF
D008479	C04.588.894.479|C08.846.187.580	Mediastinal Neoplasms	Tumors or cancer of the MEDIASTINUM.	""	0	#FFFFFF
D008480	C08.846.187.790	Mediastinitis	Inflammation of the mediastinum, the area between the pleural sacs.	""	0	#FFFFFF
D008527	C04.557.465.625.600.380.515|C04.557.465.625.600.590.500|C04.557.470.670.380.515|C04.557.470.670.590.500|C04.557.580.625.600.380.515|C04.557.580.625.600.590.500	Medulloblastoma	A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)	""	0	#FFFFFF
D008531	C06.405.469.158.701	Megacolon	Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.	""	0	#FFFFFF
D008532	C06.405.469.158.701.591	Megacolon, Toxic	An acute form of MEGACOLON, severe pathological dilatation of the COLON. It is associated with clinical conditions such as ULCERATIVE COLITIS; CROHN DISEASE; AMEBIC DYSENTERY; or CLOSTRIDIUM ENTEROCOLITIS.	""	0	#FFFFFF
D008538	C10.228.140.079.590|C10.228.662.300.500	Meige Syndrome	A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108)	""	0	#FFFFFF
D008539	C04.588.322.455.531|C12.050.351.500.056.630.705.531|C12.050.351.937.418.685.531|C12.100.250.056.630.705.531|C12.900.418.685.531|C19.344.410.531|C19.391.630.705.531	Meigs Syndrome	The triad of benign FIBROMA or other ovarian tumors with ASCITES, and HYDROTHORAX due to large PLEURAL EFFUSIONS.	""	0	#FFFFFF
D008545	C04.557.465.625.650.510|C04.557.580.625.650.510|C04.557.665.510	Melanoma	A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	""	0	#FFFFFF
D008546	C04.557.465.625.650.510.525|C04.557.580.625.650.510.525|C04.557.665.510.525|C04.619.600	Melanoma, Experimental	Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.	""	0	#FFFFFF
D008548	C17.800.621.430.530	Melanosis	Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.	""	0	#FFFFFF
D008551	C06.405.227.600|C23.550.414.788.600	Melena	The black, tarry, foul-smelling FECES that contain degraded blood.	""	0	#FFFFFF
D008554	C01.150.252.400.170.531	Melioidosis	A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.	""	0	#FFFFFF
D008556	C07.465.299.800|C07.465.466|C10.292.319.800	Melkersson-Rosenthal Syndrome	An idiopathic syndrome characterized by one or more of the following; recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue (lingua plicata). The onset is usually in childhood and relapses are common. Cheilitis granulomatosa is a monosymptomatic variant of this condition. (Dermatol Clin 1996 Apr;14(2):371-9; Magalini & Magalini, Dictionary of Medical Syndromes, 4th ed, p531)	""	0	#FFFFFF
D008557	C05.116.099.708.702.593	Melorheostosis	A form of osteosclerosis extending in a linear track mainly through one of the long bones of the upper and lower limbs.	""	0	#FFFFFF
D008569	C10.597.606.525|C23.888.592.604.529	Memory Disorders	Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.	""	0	#FFFFFF
D008575	C09.218.568.217.500	Meniere Disease	A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops.	""	0	#FFFFFF
D008577	C04.588.614.250.580|C10.551.240.500	Meningeal Neoplasms	Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.	""	0	#FFFFFF
D008579	C04.557.580.520|C04.557.645.520|C04.588.614.250.580.500|C10.551.240.500.500	Meningioma	A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)	""	0	#FFFFFF
D008580	C10.597.544|C23.888.592.544	Meningism	A condition characterized by neck stiffness, headache, and other symptoms suggestive of meningeal irritation, but without actual inflammation of the meninges (MENINGITIS). Spinal fluid pressure may be elevated but spinal fluid is normal. (DeJong, The Neurologic Examination, 4th ed, p673)	""	0	#FFFFFF
D008581	C10.586.625	Meningitis	Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)	""	0	#FFFFFF
D008582	C10.586.625.220	Meningitis, Aseptic	A syndrome characterized by headache, neck stiffness, low grade fever, and CSF lymphocytic pleocytosis in the absence of an acute bacterial pathogen. Viral meningitis is the most frequent cause although MYCOPLASMA INFECTIONS; RICKETTSIA INFECTIONS; diagnostic or therapeutic procedures; NEOPLASTIC PROCESSES; septic perimeningeal foci; and other conditions may result in this syndrome. (From Adams et al., Principles of Neurology, 6th ed, p745)	""	0	#FFFFFF
D008583	C01.150.252.223.500.425|C01.150.252.400.700.433.615|C01.207.180.500.425|C10.228.228.180.500.425|C10.586.625.280.393	Meningitis, Haemophilus	Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.	""	0	#FFFFFF
D008584	C01.150.252.223.500.500|C01.150.252.410.514.533|C01.207.180.500.500|C10.228.228.180.500.500|C10.586.625.280.449	Meningitis, Listeria	Inflammation of the meninges caused by LISTERIA MONOCYTOGENES infection, usually occurring in individuals under the age of 3 years or over the age of 50 years. It may occur at any age in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. Clinical manifestations include FEVER, altered mentation, HEADACHE, meningeal signs, focal neurologic signs, and SEIZURES. (From Medicine 1998 Sep;77(5):313-36)	""	0	#FFFFFF
D008585	C01.150.252.223.500.750|C01.150.252.400.625.549.449|C01.207.180.500.750|C10.228.228.180.500.750|C10.586.625.280.505	Meningitis, Meningococcal	A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)	""	0	#FFFFFF
D008586	C01.150.252.223.500.875|C01.150.252.410.890.670.595|C01.207.180.500.875|C10.228.228.180.500.875|C10.586.625.280.560	Meningitis, Pneumococcal	An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)	""	0	#FFFFFF
D008587	C01.207.245.500|C01.925.182.550|C10.228.228.245.500|C10.586.625.400	Meningitis, Viral	Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)	""	0	#FFFFFF
D008588	C10.500.680.598|C16.131.666.680.598|C23.300.707.968	Meningocele	A congenital or acquired protrusion of the meninges, unaccompanied by neural tissue, through a bony defect in the skull or vertebral column.	""	0	#FFFFFF
D008589	C01.150.252.400.625.549	Meningococcal Infections	Infections with bacteria of the species NEISSERIA MENINGITIDIS.	""	0	#FFFFFF
D008590	C01.207.245.550|C01.207.570|C10.228.140.430.550|C10.228.228.245.550|C10.228.228.570|C10.586.250.550|C10.586.625.500	Meningoencephalitis	An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.	""	0	#FFFFFF
D008591	C10.500.680.610|C16.131.666.680.610	Meningomyelocele	Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)	""	0	#FFFFFF
D008594	C12.050.351.500.056.630.250|C12.100.250.056.630.250	Menopause, Premature	The premature cessation of menses (MENSTRUATION) when the last menstrual period occurs in a woman under the age of 40. It is due to the depletion of OVARIAN FOLLICLES. Premature MENOPAUSE can be caused by diseases; OVARIECTOMY; RADIATION; chemicals; and chromosomal abnormalities.	""	0	#FFFFFF
D008595	C12.050.351.500.852.691.449|C12.100.250.852.691.449|C23.550.414.993.350|C23.550.568.875	Menorrhagia	Excessive uterine bleeding during MENSTRUATION.	""	0	#FFFFFF
D008599	C23.550.568	Menstruation Disturbances	Variations of MENSTRUATION which may be indicative of disease.	""	0	#FFFFFF
D008607	C10.597.606.360|C23.888.592.604.646	Intellectual Disability	Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)	""	0	#FFFFFF
D008630	C25.723.522.875	Mercury Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of MERCURY or MERCURY COMPOUNDS.	""	0	#FFFFFF
D008637	C04.557.435.500	Mesenchymoma	A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)	""	0	#FFFFFF
D008639	C04.182.473|C06.844.620.500	Mesenteric Cyst	A rare intra-abdominal tumor in the MESENTERY. Mesenteric cysts are usually benign and can be very large fluid-filled (2000 mL) lesions.	""	0	#FFFFFF
D008640	C06.844.520|C15.604.315.618	Mesenteric Lymphadenitis	INFLAMMATION of LYMPH NODES in the MESENTERY.	""	0	#FFFFFF
D008641	C06.405.469.675|C06.844.550|C14.907.137.534	Mesenteric Vascular Occlusion	Obstruction of the flow in the SPLANCHNIC CIRCULATION by ATHEROSCLEROSIS; EMBOLISM; THROMBOSIS; STENOSIS; TRAUMA; and compression or intrinsic pressure from adjacent tumors. Rare causes are drugs, intestinal parasites, and vascular immunoinflammatory diseases such as PERIARTERITIS NODOSA and THROMBOANGIITIS OBLITERANS. (From Juergens et al., Peripheral Vascular Diseases, 5th ed, pp295-6)	""	0	#FFFFFF
D008644	C07.465.714.836.535	Mesial Movement of Teeth	Migration of the teeth toward the midline or forward in the DENTAL ARCH. (From Boucher's Clinical Dental Terminology, 4th ed)	""	0	#FFFFFF
D008649	C04.557.465.510	Mesonephroma	A rare tumor of the female genital tract, most often the ovary, formerly considered to be derived from mesonephric rests. Two varieties are recognized: (1) clear cell carcinoma, so called because of its histologic resemblance to renal cell carcinoma, and now considered to be of muellerian duct derivation and (2) an embryonal tumor (called also ENDODERMAL SINUS TUMOR and yolk sac tumor), occurring chiefly in children. The latter variety may also arise in the testis. (Dorland, 27th ed)	""	0	#FFFFFF
D008654	C04.557.470.035.510|C04.557.470.660.510	Mesothelioma	A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)	""	0	#FFFFFF
D008659	C18.452	Metabolic Diseases	Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)	""	0	#FFFFFF
D008661	C16.320.565|C18.452.648	Metabolism, Inborn Errors	Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.	""	0	#FFFFFF
D008664	C16.320.565.618|C18.452.648.618	Metal Metabolism, Inborn Errors	Dysfunctions in the metabolism of metals resulting from inborn genetic mutations that are inherited or acquired in utero.	""	0	#FFFFFF
D008679	C23.550.589	Metaplasia	A condition in which there is a change of one adult cell type to another similar adult cell type.	""	0	#FFFFFF
D008708	C15.378.619	Methemoglobinemia	The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)	""	0	#FFFFFF
D008796	C12.050.351.500.852.691.622|C12.100.250.852.691.622|C23.550.414.993.700	Metrorrhagia	Abnormal uterine bleeding that is not related to MENSTRUATION, usually in females without regular MENSTRUAL CYCLE. The irregular and unpredictable bleeding usually comes from a dysfunctional ENDOMETRIUM.	""	0	#FFFFFF
D008831	C05.660.207.620|C10.500.507.400.500|C16.131.621.207.620|C16.131.666.507.400.500	Microcephaly	A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)	""	0	#FFFFFF
D008844	C05.500.460.457|C05.660.207.540.460.457|C07.320.440.457|C07.650.500.460.457|C16.131.621.207.540.460.457|C16.131.850.500.460.457	Micrognathism	Abnormally small jaw.	""	0	#FFFFFF
D008850	C11.250.566|C16.131.384.666	Microphthalmos	Congenital or developmental anomaly in which the eyeballs are abnormally small.	""	0	#FFFFFF
D008865	C07.465.525.520|C07.650.525.520|C16.131.850.525.520	Microstomia	A congenital defect in which the mouth is unusually small. (Dorland, 27th ed)	""	0	#FFFFFF
D008878	C08.381.730.542	Middle Lobe Syndrome	Atelectasis of the right middle pulmonary lobe, with chronic pneumonitis. (Dorland, 27th ed)	""	0	#FFFFFF
D008881	C10.228.140.546.399.750	Migraine Disorders	A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	""	0	#FFFFFF
D008882	C07.465.815.355	Mikulicz' Disease	A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.	""	0	#FFFFFF
D008883	C17.800.946.492	Miliaria	A syndrome of cutaneous changes associated with sweat retention and extravasation of sweat at different levels in the skin. Miliaria rubra, or prickly heat, results from apocrine duct obstruction. The sweat then seeps into the epidermis, producing pruritic erythematous papulovesicles. (From Dorland, 27th ed)	""	0	#FFFFFF
D008924	C01.610.858.211.480	Mite Infestations	Infestations with arthropods of the subclass ACARI, superorder Acariformes.	""	0	#FFFFFF
D008944	C14.280.484.461	Mitral Valve Insufficiency	Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.	""	0	#FFFFFF
D008945	C14.280.484.400.500	Mitral Valve Prolapse	Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.	""	0	#FFFFFF
D008946	C14.280.484.517	Mitral Valve Stenosis	Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.	""	0	#FFFFFF
D008947	C17.300.540	Mixed Connective Tissue Disease	"A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a ""speckled"" epidermal nuclear staining pattern on direct immunofluorescence."	""	0	#FFFFFF
D008949	C04.557.435.090|C04.557.470.035.155	Adenoma, Pleomorphic	A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)	""	0	#FFFFFF
D008976	C01.925.256.743.611|C01.925.825.550|C17.800.838.790.550	Molluscum Contagiosum	A common, benign, usually self-limited viral infection of the skin and occasionally the conjunctivae by a poxvirus (MOLLUSCUM CONTAGIOSUM VIRUS). (Dorland, 27th ed)	""	0	#FFFFFF
D008989	C01.610.335.190.628|C01.610.335.349.656|C01.610.701.377.656|C22.674.377.656	Monieziasis	Infection of ruminants with tapeworms of the genus Moniezia.	""	0	#FFFFFF
D008992	C22.735.500	Monkey Diseases	Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).	""	0	#FFFFFF
D008998	C15.378.147.542.640|C15.378.147.780.570|C20.683.460.640|C20.683.780.640	Monoclonal Gammopathy of Undetermined Significance	Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.	""	0	#FFFFFF
D009006	C23.550.210.050.500	Monosomy	The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.	""	0	#FFFFFF
D009008	C16.131.085	Abnormalities, Severe Teratoid	Marked developmental anomalies of a fetus or infant.	""	0	#FFFFFF
D009011	C05.550.518.336.750|C26.289.336.750|C26.404.937.547	Monteggia's Fracture	Fracture in the proximal half of the shaft of the ulna, with dislocation of the head of the radius.	""	0	#FFFFFF
D009021	C25.775.643.500.600	Morphine Dependence	Strong dependence, both physiological and emotional, upon morphine.	""	0	#FFFFFF
D009041	C23.888.571	Motion Sickness	Disorder caused by motion. It includes sea sickness, train sickness, roller coaster rides, rocking chair, hammock swing, car sickness, air sickness, or SPACE MOTION SICKNESS. Symptoms include nausea, vomiting and/or dizziness.	""	0	#FFFFFF
D009050	C07.793.330	Fluorosis, Dental	A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)	""	0	#FFFFFF
D009056	C07.465.525|C07.650.525|C16.131.850.525	Mouth Abnormalities	Congenital absence of or defects in structures of the mouth.	""	0	#FFFFFF
D009057	C07	Stomatognathic Diseases	General or unspecified diseases of the stomatognathic system, comprising the mouth, teeth, jaws, and pharynx.	""	0	#FFFFFF
D009058	C08.618.659|C23.888.852.761	Mouth Breathing	Abnormal breathing through the mouth, usually associated with obstructive disorders of the nasal passages.	""	0	#FFFFFF
D009059	C07.465	Mouth Diseases	Diseases involving the MOUTH.	""	0	#FFFFFF
D009062	C04.588.443.591|C07.465.530	Mouth Neoplasms	Tumors or cancer of the MOUTH.	""	0	#FFFFFF
D009066	C07.465.550|C07.793.597	Mouth, Edentulous	Total lack of teeth through disease or extraction.	""	0	#FFFFFF
D009069	C10.228.662	Movement Disorders	Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.	""	0	#FFFFFF
D009072	C10.228.140.300.200.600|C10.228.140.300.510.200.737|C14.907.137.615|C14.907.253.123.620|C14.907.253.560.200.737	Moyamoya Disease	A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.	""	0	#FFFFFF
D009078	C04.182.511	Mucocele	A retention cyst of the salivary gland, lacrimal sac, paranasal sinuses, appendix, or gallbladder. (Stedman, 26th ed)	""	0	#FFFFFF
D009080	C14.907.940.560|C15.604.560|C17.800.862.560	Mucocutaneous Lymph Node Syndrome	An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.	""	0	#FFFFFF
D009081	C05.116.198.371|C10.228.140.163.100.435.590|C16.320.565.189.435.590|C16.320.565.202.670|C16.320.565.595.554.590|C18.452.132.100.435.590|C18.452.648.189.435.590|C18.452.648.202.670|C18.452.648.595.554.590	Mucolipidoses	A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. INTELLECTUAL DISABILITY and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)	""	0	#FFFFFF
D009083	C16.320.565.202.715|C16.320.565.595.600|C17.300.550.575|C18.452.648.202.715|C18.452.648.595.600	Mucopolysaccharidoses	Group of lysosomal storage diseases each caused by an inherited deficiency of an enzyme involved in the degradation of glycosaminoglycans (mucopolysaccharides). The diseases are progressive and often display a wide spectrum of clinical severity within one enzyme deficiency.	""	0	#FFFFFF
D009084	C16.320.565.202.715.650|C16.320.565.595.600.650|C17.300.550.575.650|C18.452.648.202.715.650|C18.452.648.595.600.650	Mucopolysaccharidosis III	Mucopolysaccharidosis characterized by heparitin sulfate in the urine, progressive mental retardation, mild dwarfism, and other skeletal disorders. There are four clinically indistinguishable but biochemically distinct forms, each due to a deficiency of a different enzyme.	""	0	#FFFFFF
D009085	C16.320.565.202.715.655|C16.320.565.595.600.655|C17.300.550.575.655|C18.452.648.202.715.655|C18.452.648.595.600.655	Mucopolysaccharidosis IV	Genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate. There are two biochemically distinct forms, each due to a deficiency of a different enzyme.	""	0	#FFFFFF
D009087	C16.320.565.202.715.670|C16.320.565.595.600.670|C17.300.550.575.670|C18.452.648.202.715.670|C18.452.648.595.600.670	Mucopolysaccharidosis VI	Mucopolysaccharidosis with excessive CHONDROITIN SULFATE B in urine, characterized by dwarfism and deafness. It is caused by a deficiency of N-ACETYLGALACTOSAMINE-4-SULFATASE (arylsulfatase B).	""	0	#FFFFFF
D009091	C01.150.703.980.600	Mucormycosis	Infection in humans and animals caused by any fungus in the order MUCORALES (e.g., RHIZOPUS; MUCOR; CUNNINGHAMELLA; APOPHYSOMYCES; ABSIDIA; SAKSENAEA and RHIZOMUCOR) There are many clinical types associated with infection including central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an OPPORTUNISTIC INFECTION.	""	0	#FFFFFF
D009100	C16.320.565.100.620|C16.320.565.202.720|C18.452.648.100.620|C18.452.648.202.720	Multiple Carboxylase Deficiency	A deficiency in the activities of biotin-dependent enzymes (propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, and PYRUVATE CARBOXYLASE) due to one of two defects in BIOTIN metabolism. The neonatal form is due to HOLOCARBOXYLASE SYNTHETASE DEFICIENCY. The late-onset form is due to BIOTINIDASE DEFICIENCY.	""	0	#FFFFFF
D009101	C04.557.595.500|C14.907.454.460|C15.378.147.780.650|C15.378.463.515.460|C20.683.515.845|C20.683.780.650	Multiple Myeloma	A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	""	0	#FFFFFF
D009102	C23.550.835.525	Multiple Organ Failure	A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.	""	0	#FFFFFF
D009103	C10.114.375.500|C10.314.350.500|C20.111.258.250.500	Multiple Sclerosis	An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)	""	0	#FFFFFF
D009104	C26.640	Multiple Trauma	Multiple physical insults or injuries occurring simultaneously.	""	0	#FFFFFF
D009107	C01.925.782.580.600.680.500|C07.465.815.470.800.630	Mumps	An acute infectious disease caused by RUBULAVIRUS, spread by direct contact, airborne droplet nuclei, fomites contaminated by infectious saliva, and perhaps urine, and usually seen in children under the age of 15, although adults may also be affected. (From Dorland, 28th ed)	""	0	#FFFFFF
D009120	C05.651.475|C10.597.613.500|C23.888.592.608.500	Muscle Cramp	A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)	""	0	#FFFFFF
D009122	C10.597.613.550|C23.888.592.608.550	Muscle Hypertonia	Abnormal increase in skeletal or smooth muscle tone. Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES.	""	0	#FFFFFF
D009123	C10.597.613.575|C23.888.592.608.575	Muscle Hypotonia	A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching.	""	0	#FFFFFF
D009127	C05.651.504|C10.597.613.550.500|C23.888.592.608.550.500	Muscle Rigidity	Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)	""	0	#FFFFFF
D009128	C05.651.512|C10.597.613.550.550|C23.888.592.608.550.550	Muscle Spasticity	"A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a ""free interval"") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)"	""	0	#FFFFFF
D009133	C10.597.613.612|C23.300.070.500|C23.888.592.608.612	Muscular Atrophy	Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.	""	0	#FFFFFF
D009134	C10.228.854.468|C10.574.562.500|C10.668.467.500	Muscular Atrophy, Spinal	A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)	""	0	#FFFFFF
D009135	C05.651|C10.668.491	Muscular Diseases	Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.	""	0	#FFFFFF
D009136	C05.651.534.500|C10.668.491.175.500|C16.320.577	Muscular Dystrophies	A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.	""	0	#FFFFFF
D009137	C22.595	Muscular Dystrophy, Animal	MUSCULAR DYSTROPHY that occurs in VERTEBRATE animals.	""	0	#FFFFFF
D009139	C05.660|C16.131.621	Musculoskeletal Abnormalities	Congenital structural abnormalities and deformities of the musculoskeletal system.	""	0	#FFFFFF
D009140	C05	Musculoskeletal Diseases	Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.	""	0	#FFFFFF
D009145	C25.723.415.551|C25.723.680.551	Mushroom Poisoning	Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.	""	0	#FFFFFF
D009155	C10.597.606.150.500.800.500|C23.888.592.604.150.500.800.500	Mutism	The inability to generate oral-verbal expression, despite normal comprehension of speech. This may be associated with BRAIN DISEASES or MENTAL DISORDERS. Organic mutism may be associated with damage to the FRONTAL LOBE; BRAIN STEM; THALAMUS; and CEREBELLUM. Selective mutism is a psychological condition that usually affects children characterized by continuous refusal to speak in social situations by a child who is able and willing to speak to selected persons. Kussmal aphasia refers to mutism in psychosis. (From Fortschr Neurol Psychiatr 1994; 62(9):337-44)	""	0	#FFFFFF
D009157	C04.588.614.550.500|C04.730.856.490|C10.114.656|C10.574.781.588|C10.668.758.725|C20.111.258.500	Myasthenia Gravis	A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.	""	0	#FFFFFF
D009164	C01.150.252.410.040.552	Mycobacterium Infections	Infections with bacteria of the genus MYCOBACTERIUM.	""	0	#FFFFFF
D009165	C01.150.252.410.040.552.475	Mycobacterium Infections, Nontuberculous	Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae, M. leprae.	""	0	#FFFFFF
D009175	C01.150.252.400.610.610	Mycoplasma Infections	Infections with species of the genus MYCOPLASMA.	""	0	#FFFFFF
D009180	C01.150.252.400.610	Mycoplasmatales Infections	Infections with bacteria of the order MYCOPLASMATALES.	""	0	#FFFFFF
D009181	C01.150.703	Mycoses	Diseases caused by FUNGI.	""	0	#FFFFFF
D009182	C04.557.386.480.750.800.550|C15.604.515.569.480.750.800.550|C20.683.515.761.480.750.800.550	Mycosis Fungoides	A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.	""	0	#FFFFFF
D009187	C01.207.618|C10.228.228.618|C10.228.854.525|C10.586.750	Myelitis	Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.	""	0	#FFFFFF
D009188	C01.207.618.250|C04.588.614.550.550|C04.730.856.543|C10.114.375.600|C10.228.228.618.250|C10.228.854.525.553|C10.314.350.600|C10.574.781.625|C10.586.750.553|C20.111.258.250.550	Myelitis, Transverse	Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)	""	0	#FFFFFF
D009190	C15.378.190.625	Myelodysplastic Syndromes	Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.	""	0	#FFFFFF
D009196	C15.378.190.636	Myeloproliferative Disorders	Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.	""	0	#FFFFFF
D009198	C01.610.858.211.503	Myiasis	The invasion of living tissues of man and other mammals by dipterous larvae.	""	0	#FFFFFF
D009202	C14.280.238	Cardiomyopathies	A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	""	0	#FFFFFF
D009203	C14.280.647.500|C14.907.585.500|C23.550.513.355.750|C23.550.717.489.750	Myocardial Infarction	NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	""	0	#FFFFFF
D009205	C14.280.238.625	Myocarditis	Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.	""	0	#FFFFFF
D009207	C10.597.350.500|C23.888.592.350.500	Myoclonus	Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).	""	0	#FFFFFF
D009208	C04.557.435.585	Myoepithelioma	A usually benign tumor made up predominantly of myoepithelial cells.	""	0	#FFFFFF
D009209	C05.651.550	Myofascial Pain Syndromes	Muscular pain in numerous body regions that can be reproduced by pressure on TRIGGER POINTS, localized hardenings in skeletal muscle tissue. Pain is referred to a location distant from the trigger points. A prime example is the TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME.	""	0	#FFFFFF
D009212	C05.651.807.628	Myoglobinuria	The presence of MYOGLOBIN in URINE usually as a result of rhabdomyolysis.	""	0	#FFFFFF
D009214	C04.557.450.590.540	Myoma	A benign neoplasm of muscular tissue. (Stedman, 25th ed)	""	0	#FFFFFF
D009216	C11.744.636	Myopia	A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.	""	0	#FFFFFF
D009217	C04.557.450.590.550|C04.557.450.795.550	Myosarcoma	A general term for a malignant neoplasm derived from muscular tissue. (Stedman, 25th ed)	""	0	#FFFFFF
D009220	C05.651.594|C10.668.491.562	Myositis	Inflammation of a muscle or muscle tissue.	""	0	#FFFFFF
D009221	C05.651.594.638	Myositis Ossificans	A disease characterized by bony deposits or the ossification of muscle tissue.	""	0	#FFFFFF
D009222	C10.597.613.700|C23.888.592.608.700	Myotonia	Prolonged failure of muscle relaxation after contraction. This may occur after voluntary contractions, muscle percussion, or electrical stimulation of the muscle. Myotonia is a characteristic feature of MYOTONIC DISORDERS.	""	0	#FFFFFF
D009223	C05.651.534.500.500|C05.651.662.750|C10.574.500.547|C10.668.491.175.500.500|C10.668.491.606.750|C16.320.400.542|C16.320.577.500	Myotonic Dystrophy	Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.	""	0	#FFFFFF
D009224	C05.651.662.500|C10.574.500.545|C10.668.491.606.500|C16.320.400.540	Myotonia Congenita	Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulation and other movements. It is classified as Thomsen (autosomal dominant) or Becker (autosomal recessive) generalized myotonia mainly based on the inheritance pattern. Becker type is also clinically more severe. An autosomal dominant variant with milder symptoms and later onset is known as myotonia levior. Mutations in the voltage-dependent skeletal muscle chloride channel are associated with the disorders.	""	0	#FFFFFF
D009230	C17.300.550.590|C19.874.482.638	Myxedema	A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.	""	0	#FFFFFF
D009232	C04.557.450.565.550	Myxoma	A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. It occurs frequently intramuscularly where it may be mistaken for a sarcoma. It appears also in the jaws and the skin. (From Stedman, 25th ed)	""	0	#FFFFFF
D009234	C01.925.256.743.665|C22.627	Myxomatosis, Infectious	Diseases caused by MYXOMA VIRUS.	""	0	#FFFFFF
D009236	C04.557.450.565.560|C04.557.450.795.560	Myxosarcoma	A sarcoma, usually a liposarcoma or malignant fibrous histiocytoma, with an abundant component of myxoid tissue resembling primitive mesenchyme containing connective tissue mucin. (Stedman, 25th ed)	""	0	#FFFFFF
D009260	C17.800.529	Nail Diseases	Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.	""	0	#FFFFFF
D009261	C05.550.629|C16.131.077.606|C16.320.600|C17.800.529.400	Nail-Patella Syndrome	A syndrome of multiple abnormalities characterized by the absence or hypoplasia of the PATELLA and congenital nail dystrophy. It is a genetically determined autosomal dominant trait.	""	0	#FFFFFF
D009263	C17.800.529.406	Nails, Ingrown	Excessive lateral nail growth into the nail fold. Because the lateral margin of the nail acts as a foreign body, inflammation and granulation may result. It is caused by improperly fitting shoes and by improper trimming of the nail.	""	0	#FFFFFF
D009264	C23.300.820	Nails, Malformed	Deformities in nail structure or appearance, including hypertrophy, splitting, clubbing, furrowing, etc. Genetic diseases such as PACHYONYCHIA CONGENITA can result in malformed nails.	""	0	#FFFFFF
D009265	C01.920.500.614|C01.920.930.550|C01.925.081.678|C01.925.782.147.633|C22.836.583	Nairobi Sheep Disease	An arbovirus infection of sheep and goats transmitted by ticks. It is characterized by high fever and hemorrhagic gastroenteritis.	""	0	#FFFFFF
D009290	C10.886.425.800.200.750	Narcolepsy	A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)	""	0	#FFFFFF
D009293	C25.775.643.500	Opioid-Related Disorders	Disorders related to or resulting from abuse or misuse of OPIOIDS.	""	0	#FFFFFF
D009298	C08.460.572|C09.603.557|C23.300.825.557	Nasal Polyps	Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.	""	0	#FFFFFF
D009302	C07.550.350|C09.775.350	Nasopharyngeal Diseases	Pathological processes involving the NASOPHARYNX.	""	0	#FFFFFF
D009303	C04.588.443.665.710.650|C07.550.350.650|C07.550.745.650|C09.647.710.650|C09.775.350.650|C09.775.549.650	Nasopharyngeal Neoplasms	Tumors or cancer of the NASOPHARYNX.	""	0	#FFFFFF
D009304	C01.748.561.500|C07.550.350.700|C07.550.781.500|C08.730.561.500|C09.775.350.700|C09.775.649.500	Nasopharyngitis	Inflammation of the NASOPHARYNX, usually including its mucosa, related lymphoid structure, and glands.	""	0	#FFFFFF
D009325	C23.888.821.712	Nausea	An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.	""	0	#FFFFFF
D009332	C01.610.335.508.700.775.455.683	Necatoriasis	Infection of humans or animals with hookworms of the genus NECATOR. The resulting anemia from this condition is less severe than that from ANCYLOSTOMIASIS.	""	0	#FFFFFF
D009335	C17.300.200.495.545|C17.800.550.545|C17.800.849.495|C18.452.880.495	Necrobiosis Lipoidica	A degenerative disease of the dermal connective tissue characterized by the development of erythematous papules or nodules in the pretibial area. The papules form plaques covered with telangiectatic vessels. More than half of the affected patients have diabetes.	""	0	#FFFFFF
D009336	C23.550.717	Necrosis	The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	""	0	#FFFFFF
D009347	C04.588.322.609.145.500|C10.228.140.617.738.675.149.500|C19.344.609.145.500|C19.700.734.145.500	Nelson Syndrome	A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.	""	0	#FFFFFF
D009349	C01.610.335.508	Nematode Infections	Infections by nematodes, general or unspecified.	""	0	#FFFFFF
D009357	C16.614.610|C25.775.650	Neonatal Abstinence Syndrome	Fetal and neonatal addiction and withdrawal as a result of the mother's dependence on drugs during pregnancy. Withdrawal or abstinence symptoms develop shortly after birth. Symptoms exhibited are loud, high-pitched crying, sweating, yawning and gastrointestinal disturbances.	""	0	#FFFFFF
D009358	C16	Congenital, Hereditary, and Neonatal Diseases and Abnormalities	Diseases existing at birth and often before birth, or that develop during the first month of life (INFANT, NEWBORN, DISEASES), regardless of causation. Of these diseases, those characterized by structural deformities are termed CONGENITAL ABNORMALITIES.	""	0	#FFFFFF
D009360	C04.697.650.900|C23.550.727.650.900	Neoplastic Cells, Circulating	Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors.	""	0	#FFFFFF
D009361	C04.697.645|C23.550.727.645	Neoplasm Invasiveness	Ability of neoplasms to infiltrate and actively destroy surrounding tissue.	""	0	#FFFFFF
D009362	C04.697.650|C23.550.727.650	Neoplasm Metastasis	The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	""	0	#FFFFFF
D009364	C04.697.655|C23.550.727.655	Neoplasm Recurrence, Local	The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.	""	0	#FFFFFF
D009365	C04.697.670|C23.550.727.670	Neoplasm Regression, Spontaneous	Disappearance of a neoplasm or neoplastic state without the intervention of therapy.	""	0	#FFFFFF
D009366	C04.697.650.830|C23.550.727.650.830	Neoplasm Seeding	The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.	""	0	#FFFFFF
D009369	C04	Neoplasms	New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	""	0	#FFFFFF
D009370	C04.557	Neoplasms by Histologic Type	A collective term for the various histological types of NEOPLASMS. It is more likely to be used by searchers than by indexers and catalogers.	""	0	#FFFFFF
D009371	C04.588	Neoplasms by Site	A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.	""	0	#FFFFFF
D009372	C04.557.450.565|C17.300.680	Neoplasms, Connective Tissue	Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.	""	0	#FFFFFF
D009373	C04.557.465	Neoplasms, Germ Cell and Embryonal	Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.	""	0	#FFFFFF
D009374	C04.619	Neoplasms, Experimental	Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.	""	0	#FFFFFF
D009375	C04.557.470	Neoplasms, Glandular and Epithelial	Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.	""	0	#FFFFFF
D009376	C04.626	Neoplasms, Hormone-Dependent	Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.	""	0	#FFFFFF
D009377	C04.588.322.400|C04.651.600|C04.700.630|C16.320.700.630|C19.344.400	Multiple Endocrine Neoplasia	A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.	""	0	#FFFFFF
D009378	C04.651	Neoplasms, Multiple Primary	Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.	""	0	#FFFFFF
D009379	C04.557.450.590	Neoplasms, Muscle Tissue	Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.	""	0	#FFFFFF
D009380	C04.557.580	Neoplasms, Nerve Tissue	Neoplasms composed of nerve tissue. This concept does not refer to neoplasms located in the nervous system or its component nerves.	""	0	#FFFFFF
D009381	C04.682|C26.733.476	Neoplasms, Radiation-Induced	Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.	""	0	#FFFFFF
D009382	C04.697.650.895|C23.550.727.650.895	Neoplasms, Unknown Primary	Metastases in which the tissue of origin is unknown.	""	0	#FFFFFF
D009383	C04.557.645	Neoplasms, Vascular Tissue	Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.	""	0	#FFFFFF
D009384	C04.588.322.490|C04.730.713|C19.344.473	Paraneoplastic Endocrine Syndromes	Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.	""	0	#FFFFFF
D009385	C04.697|C23.550.727	Neoplastic Processes	The pathological mechanisms and forms taken by tissue during degeneration into a neoplasm and its subsequent activity.	""	0	#FFFFFF
D009386	C04.700|C16.320.700	Neoplastic Syndromes, Hereditary	The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.	""	0	#FFFFFF
D009389	C23.550.589.500	Neovascularization, Pathologic	A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.	""	0	#FFFFFF
D009393	C12.050.351.968.419.570|C12.200.777.419.570|C12.950.419.570	Nephritis	Inflammation of any part of the KIDNEY.	""	0	#FFFFFF
D009394	C12.050.351.875.742|C12.050.351.968.419.570.620|C12.200.706.742|C12.200.777.419.570.620|C12.800.742|C12.950.419.570.620|C16.131.939.742|C17.300.200.517	Nephritis, Hereditary	A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.	""	0	#FFFFFF
D009395	C12.050.351.968.419.570.643|C12.200.777.419.570.643|C12.950.419.570.643	Nephritis, Interstitial	Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.	""	0	#FFFFFF
D009396	C04.557.435.595|C04.588.945.947.535.585|C04.700.900|C12.050.351.937.820.535.585|C12.050.351.968.419.473.585|C12.200.758.820.750.585|C12.200.777.419.473.585|C12.900.820.535.585|C12.950.419.473.585|C12.950.983.535.585|C16.320.700.900	Wilms Tumor	A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.	""	0	#FFFFFF
D009397	C12.050.351.968.419.590|C12.200.777.419.590|C12.950.419.590|C18.452.174.130.560	Nephrocalcinosis	A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.	""	0	#FFFFFF
D009400	C12.050.351.968.419.610|C12.200.777.419.610|C12.950.419.610	Nephrosclerosis	Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.	""	0	#FFFFFF
D009401	C12.050.351.968.419.630|C12.200.777.419.630|C12.950.419.630	Nephrosis	Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.	""	0	#FFFFFF
D009402	C12.050.351.968.419.630.477|C12.200.777.419.630.477|C12.950.419.630.477	Nephrosis, Lipoid	A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.	""	0	#FFFFFF
D009404	C12.050.351.968.419.630.643|C12.200.777.419.630.643|C12.950.419.630.643	Nephrotic Syndrome	A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.	""	0	#FFFFFF
D009408	C10.668.829.550	Nerve Compression Syndromes	Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect.	""	0	#FFFFFF
D009410	C23.550.737	Nerve Degeneration	Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.	""	0	#FFFFFF
D009421	C10.500|C16.131.666	Nervous System Malformations	Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.	""	0	#FFFFFF
D009422	C10	Nervous System Diseases	Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	""	0	#FFFFFF
D009423	C04.588.614|C10.551	Nervous System Neoplasms	Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.	""	0	#FFFFFF
D009436	C10.500.680|C16.131.666.680	Neural Tube Defects	Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)	""	0	#FFFFFF
D009437	C10.668.829.600|C23.888.592.612.664	Neuralgia	Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	""	0	#FFFFFF
D009442	C04.557.465.625.650.595|C04.557.580.600.610.595|C04.557.580.625.650.595	Neurilemmoma	A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)	""	0	#FFFFFF
D009443	C10.668.829.650	Neuritis	A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.	""	0	#FFFFFF
D009444	C10.114.703.700|C10.668.829.650.500|C20.111.258.625.700	Neuritis, Autoimmune, Experimental	An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)	""	0	#FFFFFF
D009447	C04.557.465.625.600.590.650.550|C04.557.470.670.590.650.550|C04.557.580.625.600.590.650.550	Neuroblastoma	A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	""	0	#FFFFFF
D009450	C17.800.174.660|C17.800.815.660	Neurodermatitis	An extremely variable eczematous skin disease that is presumed to be a response to prolonged vigorous scratching, rubbing, or pinching to relieve intense pruritus. It varies in intensity, severity, course, and morphologic expression in different individuals. Neurodermatitis is believed by some to be psychogenic. The circumscribed or localized form is often referred to as lichen simplex chronicus.	""	0	#FFFFFF
D009455	C04.557.580.600.580|C10.551.775.500.750|C10.668.829.725.500.600	Neurofibroma	A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)	""	0	#FFFFFF
D009456	C04.557.580.600.580.590.650|C04.700.631.650|C10.562.600.500|C10.574.500.549.400|C10.668.829.675|C16.320.400.560.400|C16.320.700.633.650	Neurofibromatosis 1	An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).	""	0	#FFFFFF
D009459	C10.228.140.079.737|C10.720.737|C25.723.705.600	Neuroleptic Malignant Syndrome	A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)	""	0	#FFFFFF
D009461	C10.597|C23.888.592	Neurologic Manifestations	Clinical signs and symptoms caused by nervous system injury or dysfunction.	""	0	#FFFFFF
D009463	C04.557.580.600.610	Neuroma	A tumor made up of nerve cells and nerve fibers. (Dorland, 27th ed)	""	0	#FFFFFF
D009464	C04.557.465.625.650.595.610|C04.557.580.600.610.595.610|C04.557.580.625.650.595.610|C04.588.614.300.015|C04.588.614.596.240.015|C09.218.807.800.675|C09.647.675|C10.292.225.750|C10.292.910.600	Neuroma, Acoustic	A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)	""	0	#FFFFFF
D009468	C10.668	Neuromuscular Diseases	A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.	""	0	#FFFFFF
D009471	C10.114.375.600.500|C10.114.375.800|C10.292.700.550.500|C10.314.350.600.500|C10.314.350.800|C11.640.576.695|C20.111.258.250.550.500|C20.111.258.250.775	Neuromyelitis Optica	A syndrome characterized by acute OPTIC NEURITIS; MYELITIS, TRANSVERSE; demyelinating and/or necrotizing lesions in the OPTIC NERVES and SPINAL CORD; and presence of specific autoantibodies to AQUAPORIN 4.	""	0	#FFFFFF
D009472	C10.574.500.550|C16.320.400.600|C16.320.565.398.641.509|C18.452.584.563.641.509|C18.452.648.398.641.509	Neuronal Ceroid-Lipofuscinoses	A group of severe neurodegenerative diseases characterized by intracellular accumulation of autofluorescent wax-like lipid materials (CEROID; LIPOFUSCIN) in neurons. There are several subtypes based on mutations of the various genes, time of disease onset, and severity of the neurological defects such as progressive DEMENTIA; SEIZURES; and visual failure.	""	0	#FFFFFF
D009477	C10.500.250|C10.574.500.493|C10.668.829.800.175|C16.131.666.310|C16.320.400.415	Hereditary Sensory and Autonomic Neuropathies	A group of inherited disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and clinically by loss of sensation and autonomic dysfunction. There are five subtypes. Type I features autosomal dominant inheritance and distal sensory involvement. Type II is characterized by autosomal inheritance and distal and proximal sensory loss. Type III is DYSAUTONOMIA, FAMILIAL. Type IV features insensitivity to pain, heat intolerance, and mental deficiency. Type V is characterized by a selective loss of pain with intact light touch and vibratory sensation. (From Joynt, Clinical Neurology, 1995, Ch51, pp142-4)	""	0	#FFFFFF
D009494	C01.150.252.223.600|C01.150.252.400.794.840.500.750|C01.150.252.400.840.500.750|C01.207.180.600|C10.228.228.180.600	Neurosyphilis	Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)	""	0	#FFFFFF
D009503	C15.378.553.546.184.564	Neutropenia	A decrease in the number of NEUTROPHILS found in the blood.	""	0	#FFFFFF
D009506	C04.557.665.560	Nevus	A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.	""	0	#FFFFFF
D009507	C04.557.665.560.615.585	Nevus of Ota	A macular lesion on the side of the FACE, involving the CONJUNCTIVA and EYELIDS, as well as the adjacent facial skin, SCLERA; OCULOMOTOR MUSCLES; and PERIOSTEUM. Histological features vary from those of a MONGOLIAN SPOT to those of a BLUE NEVUS.	""	0	#FFFFFF
D009508	C04.557.665.560.615	Nevus, Pigmented	A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.	""	0	#FFFFFF
D009521	C01.925.782.580.600.080.600|C22.131.630	Newcastle Disease	An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.	""	0	#FFFFFF
D009542	C10.228.140.163.100.435.825.700|C15.604.250.410.625|C16.320.565.189.435.825.700|C16.320.565.398.641.803.730|C16.320.565.595.554.825.700|C18.452.132.100.435.825.700|C18.452.584.563.641.803.730|C18.452.648.189.435.825.700|C18.452.648.398.641.803.730|C18.452.648.595.554.825.700	Niemann-Pick Diseases	A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.	""	0	#FFFFFF
D009617	C01.150.252.410.040.692	Nocardia Infections	Infections with bacteria of the genus NOCARDIA.	""	0	#FFFFFF
D009625	C07.465.604	Noma	A severe gangrenous process occurring predominantly in debilitated and malnourished children, especially in underdeveloped countries. It typically begins as a small vesicle or ulcer on the gingiva that rapidly becomes necrotic and spreads to produce extensive destruction of the buccal and labial mucosa and tissues of the face, which may result in severe disfigurement and even death. Various bacteria have been implicated in the etiology. (Dorland, 27th ed)	""	0	#FFFFFF
D009630	C23.550.210.645	Nondisjunction, Genetic	The failure of homologous CHROMOSOMES or CHROMATIDS to segregate during MITOSIS or MEIOSIS with the result that one daughter cell has both of a pair of parental chromosomes or chromatids and the other has none.	""	0	#FFFFFF
D009631	C04.182.089.530.660|C05.500.470.660|C07.320.450.640	Nonodontogenic Cysts	Cysts formed from epithelial inclusions in the lines of fusion of the embryonic processes which form the jaws. They include nasopalatine or incisive canal cyst, incisive papilla cyst, globulomaxillary cyst, median palatal cyst, median alveolar cyst, median mandibular cyst, and nasoalveolar cyst.	""	0	#FFFFFF
D009634	C05.660.207.690|C14.240.400.787|C14.280.400.787|C16.131.240.400.784|C16.131.621.207.690|C17.300.690	Noonan Syndrome	A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.	""	0	#FFFFFF
D009667	C08.460.619|C09.603.619	Nose Deformities, Acquired	Abnormalities of the nose acquired after birth from injury or disease.	""	0	#FFFFFF
D009668	C08.460|C09.603	Nose Diseases	Disorders of the nose, general or unspecified.	""	0	#FFFFFF
D009669	C04.588.149.721.600|C04.588.443.665.650|C05.116.231.754.600|C08.460.669|C08.785.600|C09.603.669|C09.647.685	Nose Neoplasms	Tumors or cancer of the NOSE.	""	0	#FFFFFF
D009748	C18.654	Nutrition Disorders	Disorders caused by nutritional imbalance, either overnutrition or undernutrition.	""	0	#FFFFFF
D009750	C18	Nutritional and Metabolic Diseases	A collective term for nutritional disorders resulting from poor absorption or nutritional imbalance, and metabolic disorders resulting from defects in biosynthesis (ANABOLISM) or breakdown (CATABOLISM) of endogenous substances.	""	0	#FFFFFF
D009755	C11.966.671	Night Blindness	Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)	""	0	#FFFFFF
D009759	C10.292.562.675|C11.590.400	Nystagmus, Pathologic	Involuntary movements of the eye that are divided into two types, jerk and pendular. Jerk nystagmus has a slow phase in one direction followed by a corrective fast phase in the opposite direction, and is usually caused by central or peripheral vestibular dysfunction. Pendular nystagmus features oscillations that are of equal velocity in both directions and this condition is often associated with visual loss early in life. (Adams et al., Principles of Neurology, 6th ed, p272)	""	0	#FFFFFF
D009765	C18.654.726.750.500|C23.888.144.699.500	Obesity	A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	""	0	#FFFFFF
D009767	C18.654.726.750.500.700|C23.888.144.699.500.500	Obesity, Morbid	The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.	""	0	#FFFFFF
D009783	C17.800.174.255.700|C17.800.815.255.700|C24.270	Dermatitis, Occupational	A recurrent contact dermatitis caused by substances found in the work place.	""	0	#FFFFFF
D009784	C24	Occupational Diseases	Diseases caused by factors involved in one's employment.	""	0	#FFFFFF
D009794	C23.550.744	Ochronosis	The yellowish discoloration of connective tissue due to deposition of HOMOGENTISIC ACID (a brown-black pigment). This is due to defects in the metabolism of PHENYLALANINE and TYROSINE. Ochronosis occurs in ALKAPTONURIA, but has also been associated with exposure to certain chemicals (e.g., PHENOL, trinitrophenol, BENZENE DERIVATIVES).	""	0	#FFFFFF
D009798	C11.525	Ocular Hypertension	A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.	""	0	#FFFFFF
D009800	C10.228.140.163.100.640|C12.050.351.968.419.815.720|C12.200.777.419.815.720|C12.950.419.815.720|C16.131.077.662|C16.320.322.750|C16.320.565.151.600|C16.320.565.189.640|C16.320.709|C16.320.831.750|C18.452.132.100.640|C18.452.648.151.600|C18.452.648.189.640	Oculocerebrorenal Syndrome	A sex-linked recessive disorder affecting multiple systems including the EYE, the NERVOUS SYSTEM, and the KIDNEY. Clinical features include congenital CATARACT; MENTAL RETARDATION; and renal tubular dysfunction (FANCONI SYNDROME; RENAL TUBULAR ACIDOSIS; X-LINKED HYPOPHOSPHATEMIA or vitamin-D-resistant rickets) and SCOLIOSIS. This condition is due to a deficiency of phosphatidylinositol 4,5-bisphosphate-5-phosphatase leading to defects in PHOSPHATIDYLINOSITOL metabolism and INOSITOL signaling pathway. (from Menkes, Textbook of Child Neurology, 5th ed, p60; Am J Hum Genet 1997 Jun;60(6):1384-8)	""	0	#FFFFFF
D009807	C04.182.089.530.690|C05.500.470.690|C07.320.450.670	Odontogenic Cysts	Cysts found in the jaws and arising from epithelium involved in tooth formation. They include follicular cysts (e.g., primordial cyst, dentigerous cyst, multilocular cyst), lateral periodontal cysts, and radicular cysts. They may become keratinized (odontogenic keratocysts). Follicular cysts may give rise to ameloblastomas and, in rare cases, undergo malignant transformation.	""	0	#FFFFFF
D009808	C04.557.695	Odontogenic Tumors	Neoplasms produced from tooth-forming tissues.	""	0	#FFFFFF
D009810	C04.557.695.610	Odontoma	A mixed tumor of odontogenic origin, in which both the epithelial and mesenchymal cells exhibit complete differentiation, resulting in the formation of tooth structures. (Jablonski, Illustrated Dictionary of Dentistry, 1982)	""	0	#FFFFFF
D009814	C01.610.335.508.700.775.583	Oesophagostomiasis	Infection of the intestinal tract with worms of the genus OESOPHAGOSTOMUM. This condition occurs mainly in animals other than man.	""	0	#FFFFFF
D009837	C04.557.465.625.600.380.590|C04.557.470.670.380.590|C04.557.580.625.600.380.590	Oligodendroglioma	A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)	""	0	#FFFFFF
D009839	C23.550.568.937	Oligomenorrhea	Abnormally infrequent menstruation.	""	0	#FFFFFF
D009845	C12.100.500.430.508|C12.100.750.700.508|C12.200.294.430.508	Oligospermia	A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.	""	0	#FFFFFF
D009846	C12.050.351.968.934.600|C12.200.777.934.600|C12.950.934.600|C23.888.942.400	Oliguria	Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1 ml/kg/hr depending on the age.	""	0	#FFFFFF
D009849	C10.177.575.550.375|C10.228.140.079.612.600|C10.228.140.252.700.650|C10.228.662.550.600|C10.228.854.787.750|C10.574.500.825.650|C16.320.400.780.750	Olivopontocerebellar Atrophies	A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)	""	0	#FFFFFF
D009855	C01.610.335.508.700.750.361.699|C01.610.858.650|C17.800.838.775.690	Onchocerciasis	Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.	""	0	#FFFFFF
D009869	C12.050.351.500.056.630.450|C12.050.351.500.056.750.500|C12.100.250.056.630.450|C12.100.250.056.750.500|C19.391.630.450	Oophoritis	Inflammation of the OVARY, generally caused by an ascending infection of organisms from the endocervix.	""	0	#FFFFFF
D009877	C01.375.265|C11.294.265	Endophthalmitis	Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.	""	0	#FFFFFF
D009878	C01.150.252.289.225.625|C01.150.252.400.625.774|C01.375.354.220.625|C11.187.183.220.538|C11.294.354.220.625|C16.614.677	Ophthalmia Neonatorum	Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. The causative agent is NEISSERIA GONORRHOEAE. The baby's eyes are contaminated during passage through the birth canal.	""	0	#FFFFFF
D009879	C11.941.879.780.500|C20.111.709	Ophthalmia, Sympathetic	Granulomatous uveitis which follows in one eye after a penetrating injury to the other eye; the secondarily affected eye is called the sympathizing eye, and the injured eye is called the exciting or activating eye.	""	0	#FFFFFF
D009886	C10.292.562.750|C10.597.622.447|C11.590.472|C23.888.592.636.447	Ophthalmoplegia	Paralysis of one or more of the ocular muscles due to disorders of the eye muscles, neuromuscular junction, supporting soft tissue, tendons, or innervation to the muscles.	""	0	#FFFFFF
D009889	C01.610.335.865.685	Opisthorchiasis	Infection with flukes of the genus Opisthorchis.	""	0	#FFFFFF
D009894	C01.597|C01.610.684|C01.925.597	Opportunistic Infections	An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.	""	0	#FFFFFF
D009896	C10.292.700.225|C11.640.451	Optic Atrophy	Atrophy of the optic disk which may be congenital or acquired. This condition indicates a deficiency in the number of nerve fibers which arise in the RETINA and converge to form the OPTIC DISK; OPTIC NERVE; OPTIC CHIASM; and optic tracts. GLAUCOMA; ISCHEMIA; inflammation, a chronic elevation of intracranial pressure, toxins, optic nerve compression, and inherited conditions (see OPTIC ATROPHIES, HEREDITARY) are relatively common causes of this condition.	""	0	#FFFFFF
D009901	C10.292.700|C11.640	Optic Nerve Diseases	Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.	""	0	#FFFFFF
D009902	C10.292.700.550|C11.640.576	Optic Neuritis	Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).	""	0	#FFFFFF
D009912	C07.465.634|C23.888.619	Oral Manifestations	Disorders of the mouth attendant upon non-oral disease or injury.	""	0	#FFFFFF
D009914	C07.465.654	Oral Submucous Fibrosis	Irreversible FIBROSIS of the submucosal tissue of the MOUTH.	""	0	#FFFFFF
D009916	C11.675	Orbital Diseases	Diseases of the bony orbit and contents except the eyeball.	""	0	#FFFFFF
D009917	C10.900.300.284.500.550|C26.404.750.684|C26.915.300.425.500.550	Orbital Fractures	Fractures of the bones in the orbit, which include parts of the frontal, ethmoidal, lacrimal, and sphenoid bones and the maxilla and zygoma.	""	0	#FFFFFF
D009918	C04.588.149.721.656|C04.588.364.659|C05.116.231.754.659|C11.319.457|C11.675.659	Orbital Neoplasms	Neoplasms of the bony orbit and contents except the eyeball.	""	0	#FFFFFF
D009920	C12.100.500.829.493|C12.200.294.829.493|C19.391.829.493	Orchitis	Inflammation of a TESTIS. It has many features of EPIDIDYMITIS, such as swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS and then the TESTIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.	""	0	#FFFFFF
D009956	C01.150.252.400.210.250.600	Psittacosis	Infection with CHLAMYDOPHILA PSITTACI (formerly Chlamydia psittaci), transmitted to humans by inhalation of dust-borne contaminated nasal secretions or excreta of infected BIRDS. This infection results in a febrile illness characterized by PNEUMONITIS and systemic manifestations.	""	0	#FFFFFF
D009957	C07.465.614.421|C23.300.575.500.550	Oroantral Fistula	A fistula between the maxillary sinus and the oral cavity.	""	0	#FFFFFF
D009958	C05.116.099.370.652|C05.660.207.700|C16.131.077.676|C16.131.260.830.670|C16.131.621.207.700|C16.320.180.830.670|C16.320.714	Orofaciodigital Syndromes	Two syndromes of oral, facial, and digital malformations. Type I (Papillon-Leage and Psaume syndrome, Gorlin-Psaume syndrome) is inherited as an X-linked dominant trait and is found only in females and XXY males. Type II (Mohr syndrome) is inherited as an autosomal recessive trait.	""	0	#FFFFFF
D009959	C04.588.443.665.710.684|C07.550.745.671|C09.647.710.685|C09.775.549.685	Oropharyngeal Neoplasms	Tumors or cancer of the OROPHARYNX.	""	0	#FFFFFF
D009976	C01.925.782.620	Orthomyxoviridae Infections	Virus diseases caused by the ORTHOMYXOVIRIDAE.	""	0	#FFFFFF
D009999	C23.550.751	Ossification, Heterotopic	The development of bony substance in normally soft structures.	""	0	#FFFFFF
D010000	C05.116.680	Osteitis	Inflammation of the bone.	""	0	#FFFFFF
D010001	C05.116.692	Osteitis Deformans	A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.	""	0	#FFFFFF
D010002	C05.116.132.684	Osteitis Fibrosa Cystica	A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.	""	0	#FFFFFF
D010003	C05.550.114.606|C05.799.613	Osteoarthritis	A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	""	0	#FFFFFF
D010004	C05.116.725|C05.550.648|C16.320.718	Osteoarthropathy, Primary Hypertrophic	A condition chiefly characterized by thickening of the skin of the head and distal extremities, deep folds and furrows of the skin of the forehead, cheeks, and scalp, SEBORRHEA; HYPERHIDROSIS; periostosis of the long bones, digital clubbing, and spadelike enlargement of the hands and feet. It is more prevalent in the male, and is usually first evident during adolescence. Inheritance is primarily autosomal recessive, but an autosomal dominant form exists.	""	0	#FFFFFF
D010005	C05.116.758|C05.550.684	Osteoarthropathy, Secondary Hypertrophic	Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)	""	0	#FFFFFF
D010007	C05.116.791|C05.182.520|C17.300.182.520	Osteochondritis	Inflammation of a bone and its overlaying CARTILAGE.	""	0	#FFFFFF
D010008	C05.116.791.668	Osteochondritis Dissecans	A type of osteochondritis in which articular cartilage and associated bone becomes partially or totally detached to form joint loose bodies. Affects mainly the knee, ankle, and elbow joints.	""	0	#FFFFFF
D010009	C05.116.099.708|C16.320.728	Osteochondrodysplasias	Abnormal development of cartilage and bone.	""	0	#FFFFFF
D010013	C05.116.099.708.685|C16.320.737|C17.300.200.540	Osteogenesis Imperfecta	COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.	""	0	#FFFFFF
D010014	C05.116.264.579	Osteolysis	Dissolution of bone that particularly involves the removal or loss of calcium.	""	0	#FFFFFF
D010015	C05.116.099.736|C05.116.264.579.704	Osteolysis, Essential	Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.	""	0	#FFFFFF
D010016	C04.557.450.565.575.625	Osteoma	A benign tumor composed of bone tissue or a hard tumor of bonelike structure developing on a bone (homoplastic osteoma) or on other structures (heteroplastic osteoma). (From Dorland, 27th ed)	""	0	#FFFFFF
D010017	C04.557.450.565.575.625.625	Osteoma, Osteoid	A benign osteoblastic tumor with central vascularized nidus surrounded by normal reactive bone. It occurs especially in second decade of life most commonly in the femoral neck but can occur in any bone and any site within a bone.	""	0	#FFFFFF
D010018	C05.116.198.816.640|C18.452.104.816.640|C18.452.174.845.640|C18.654.521.500.133.770.734.640	Osteomalacia	Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.	""	0	#FFFFFF
D010019	C01.160.495|C05.116.165.495	Osteomyelitis	INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.	""	0	#FFFFFF
D010020	C05.116.852|C23.550.717.732	Osteonecrosis	Death of a bone or part of a bone, either atraumatic or posttraumatic.	""	0	#FFFFFF
D010022	C05.116.099.708.702.678	Osteopetrosis	Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).	""	0	#FFFFFF
D010023	C05.116.099.708.702.685|C17.300.705	Osteopoikilosis	An asymptomatic, autosomal dominant trait in which pea-sized sclerotic spots, prominent in the metaphyseal area, are accompanied by unique cutaneous lesions. These are yellowish papules or plaques with increased elastin content. (From Cecil Textbook of Medicine, 19th ed, pp1434-35)	""	0	#FFFFFF
D010024	C05.116.198.579|C18.452.104.579	Osteoporosis	Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	""	0	#FFFFFF
D010025	C26.733.579	Osteoradionecrosis	Necrosis of bone following radiation injury.	""	0	#FFFFFF
D010026	C05.116.099.708.702	Osteosclerosis	An abnormal hardening or increased density of bone tissue.	""	0	#FFFFFF
D010029	C01.610.335.508.700.775.825.580	Ostertagiasis	A disease of herbivorous mammals, particularly cattle and sheep, caused by stomach worms of the genus OSTERTAGIA.	""	0	#FFFFFF
D010031	C09.218.705	Otitis	Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.	""	0	#FFFFFF
D010032	C09.218.705.496	Otitis Externa	Inflammation of the OUTER EAR including the external EAR CANAL, cartilages of the auricle (EAR CARTILAGE), and the TYMPANIC MEMBRANE.	""	0	#FFFFFF
D010033	C09.218.705.663	Otitis Media	Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.	""	0	#FFFFFF
D010034	C09.218.705.663.670	Otitis Media with Effusion	Inflammation of the middle ear with a clear pale yellow-colored transudate.	""	0	#FFFFFF
D010035	C01.830.694|C09.218.705.663.680	Otitis Media, Suppurative	Inflammation of the middle ear with purulent discharge.	""	0	#FFFFFF
D010038	C09	Otorhinolaryngologic Diseases	Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.	""	0	#FFFFFF
D010039	C04.588.443.665|C09.647	Otorhinolaryngologic Neoplasms	A general concept for tumors or cancer of any part of the EAR; the NOSE; the THROAT; and the PHARYNX. It is used when there is no specific heading.	""	0	#FFFFFF
D010040	C09.218.768	Otosclerosis	Formation of spongy bone in the labyrinth capsule which can progress toward the STAPES (stapedial fixation) or anteriorly toward the COCHLEA leading to conductive, sensorineural, or mixed HEARING LOSS. Several genes are associated with familial otosclerosis with varied clinical signs.	""	0	#FFFFFF
D010048	C04.182.612|C12.050.351.500.056.630.580|C12.100.250.056.630.580|C19.391.630.580	Ovarian Cysts	General term for CYSTS and cystic diseases of the OVARY.	""	0	#FFFFFF
D010049	C12.050.351.500.056.630|C12.100.250.056.630|C19.391.630	Ovarian Diseases	Pathological processes of the OVARY.	""	0	#FFFFFF
D010051	C04.588.322.455|C12.050.351.500.056.630.705|C12.050.351.937.418.685|C12.100.250.056.630.705|C12.900.418.685|C19.344.410|C19.391.630.705	Ovarian Neoplasms	Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	""	0	#FFFFFF
D010123	C01.610.335.508.700.550.550	Oxyuriasis	Infection with nematodes of the superfamily OXYUROIDEA.	""	0	#FFFFFF
D010144	C04.557.470.200.240.187.500|C04.557.470.615.275.625	Paget's Disease, Mammary	An intraductal in situ carcinoma of the breast, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells).	""	0	#FFFFFF
D010145	C04.557.470.200.025.660|C04.557.470.615.660	Paget Disease, Extramammary	A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)	""	0	#FFFFFF
D010146	C23.888.592.612	Pain	An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	""	0	#FFFFFF
D010148	C23.888.592.612.776	Pain, Intractable	Persistent pain that is refractory to some or all forms of treatment.	""	0	#FFFFFF
D010149	C23.550.767.700|C23.888.592.612.832	Pain, Postoperative	Pain during the period after surgery.	""	0	#FFFFFF
D010157	C04.588.149.721.450.692|C04.588.443.591.692|C05.116.231.754.450.692|C05.500.499.692|C07.320.515.692|C07.465.530.692	Palatal Neoplasms	Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.	""	0	#FFFFFF
D010167	C23.888.885.500	Pallor	A clinical manifestation consisting of an unnatural paleness of the skin.	""	0	#FFFFFF
D010178	C04.588.894.797.520.734|C08.381.540.734|C08.785.520.734	Pancoast Syndrome	A condition caused by an apical lung tumor (Pancoast tumor) with involvement of the nearby vertebral column and the BRACHIAL PLEXUS. Symptoms include pain in the shoulder and the arm, and atrophy of the hand.	""	0	#FFFFFF
D010181	C04.182.640|C06.689.500	Pancreatic Cyst	A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)	""	0	#FFFFFF
D010182	C06.689	Pancreatic Diseases	Pathological processes of the PANCREAS.	""	0	#FFFFFF
D010185	C06.267.775|C06.689.583|C23.300.575.185.775	Pancreatic Fistula	Abnormal passage communicating with the PANCREAS.	""	0	#FFFFFF
D010188	C06.689.276	Exocrine Pancreatic Insufficiency	A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.	""	0	#FFFFFF
D010190	C04.588.274.761|C04.588.322.475|C06.301.761|C06.689.667|C19.344.421	Pancreatic Neoplasms	Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	""	0	#FFFFFF
D010192	C04.182.640.692|C06.689.500.692	Pancreatic Pseudocyst	Cyst-like space not lined by EPITHELIUM and contained within the PANCREAS. Pancreatic pseudocysts account for most of the cystic collections in the pancreas and are often associated with chronic PANCREATITIS.	""	0	#FFFFFF
D010195	C06.689.750	Pancreatitis	INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.	""	0	#FFFFFF
D010198	C15.378.700	Pancytopenia	Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.	""	0	#FFFFFF
D010201	C17.300.710.500|C17.800.566.500	Panniculitis, Nodular Nonsuppurative	A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. They normally resolve, but tend to leave depressions in the skin. The condition is most often seen in women, alone or in association with other disorders.	""	0	#FFFFFF
D010202	C01.150.252.289.900.675|C01.150.703.320.900.675|C01.375.354.900.675|C01.375.450.900.675|C11.294.354.900.675|C11.294.450.900.675|C11.941.879.960.580	Panophthalmitis	Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture.	""	0	#FFFFFF
D010211	C10.292.700.900|C11.640.710	Papilledema	Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)	""	0	#FFFFFF
D010212	C04.557.470.700.600	Papilloma	A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	""	0	#FFFFFF
D010214	C16.320.850.475.600|C17.800.428.435.600|C17.800.827.475.600	Papillon-Lefevre Disease	Rare, autosomal recessive disorder occurring between the first and fifth years of life. It is characterized by palmoplantar keratoderma with periodontitis followed by the premature shedding of both deciduous and permanent teeth. Mutations in the gene for CATHEPSIN C have been associated with this disease.	""	0	#FFFFFF
D010217	C01.920.500.700|C01.925.081.700|C01.925.782.147.700	Phlebotomus Fever	Influenza-like febrile viral disease caused by several members of the BUNYAVIRIDAE family and transmitted mostly by the bloodsucking sandfly Phlebotomus papatasii.	""	0	#FFFFFF
D010229	C01.150.703.700	Paracoccidioidomycosis	A mycosis affecting the skin, mucous membranes, lymph nodes, and internal organs. It is caused most often by Paracoccidioides brasiliensis. It is also called paracoccidioidal granuloma.	""	0	#FFFFFF
D010235	C04.557.465.625.650.700|C04.557.580.625.650.700	Paraganglioma	A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D010236	C04.557.465.625.650.700.705|C04.557.580.625.650.700.705	Paraganglioma, Extra-Adrenal	A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the CAROTID BODY; GLOMUS JUGULARE; GLOMUS TYMPANICUM; AORTIC BODIES; and the female genital tract. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. (From Stedman, 27th ed)	""	0	#FFFFFF
D010237	C01.610.335.865.741	Paragonimiasis	Infection with TREMATODA of the genus PARAGONIMUS.	""	0	#FFFFFF
D010241	C17.800.428.736	Parakeratosis	Persistence of the nuclei of the keratinocytes into the stratum corneum of the skin. This is a normal state only in the epithelium of true mucous membranes in the mouth and vagina. (Dorland, 27th ed)	""	0	#FFFFFF
D010243	C10.597.622|C23.888.592.636	Paralysis	A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)	""	0	#FFFFFF
D010244	C10.574.562.300|C10.668.467.300	Bulbar Palsy, Progressive	A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)	""	0	#FFFFFF
D010245	C05.651.701|C10.668.491.650|C16.320.565.618.711|C18.452.648.618.711	Paralyses, Familial Periodic	A heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia. These conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle. They are frequently associated with fluctuations in serum potassium levels. Periodic paralysis may also occur as a non-familial process secondary to THYROTOXICOSIS and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1481)	""	0	#FFFFFF
D010246	C16.614.131.587|C26.141.587	Paralysis, Obstetric	Paralysis of an infant resulting from injury received at birth. (From Dorland, 27th ed)	""	0	#FFFFFF
D010249	C12.050.351.500.056.750.750|C12.100.250.056.750.750	Parametritis	Inflammation of the parametrium, the connective tissue of the pelvic floor, extending from the subserous coat of the uterus laterally between the layers of the BROAD LIGAMENT.	""	0	#FFFFFF
D010253	C01.925.782.580.600.600	Respirovirus Infections	Infections with viruses of the genus RESPIROVIRUS, family PARAMYXOVIRIDAE. Host cell infection occurs by adsorption, via HEMAGGLUTININ, to the cell surface.	""	0	#FFFFFF
D010254	C08.460.692|C09.603.692	Paranasal Sinus Diseases	Diseases affecting or involving the PARANASAL SINUSES and generally manifesting as inflammation, abscesses, cysts, or tumors.	""	0	#FFFFFF
D010255	C04.588.443.665.650.693|C08.460.669.693|C08.460.692.503|C08.785.600.693|C09.603.669.693|C09.603.692.503|C09.647.685.693	Paranasal Sinus Neoplasms	Tumors or cancer of the PARANASAL SINUSES.	""	0	#FFFFFF
D010257	C04.730	Paraneoplastic Syndromes	In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.	""	0	#FFFFFF
D010263	C12.100.500.494.684.587|C12.200.294.494.684.587	Paraphimosis	A condition in which the FORESKIN, once retracted, cannot return to its original position. If this condition persists, it can lead to painful constriction of GLANS PENIS, swelling, and impaired blood flow to the penis.	""	0	#FFFFFF
D010264	C10.597.622.669|C23.888.592.636.637	Paraplegia	Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.	""	0	#FFFFFF
D010265	C15.378.147.780|C20.683.780	Paraproteinemias	A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.	""	0	#FFFFFF
D010267	C17.800.859.575	Parapsoriasis	The term applied to a group of relatively uncommon inflammatory, maculopapular, scaly eruptions of unknown etiology and resistant to conventional treatment. Eruptions are both psoriatic and lichenoid in appearance, but the diseases are distinct from psoriasis, lichen planus, or other recognized dermatoses. Proposed nomenclature divides parapsoriasis into two distinct subgroups, PITYRIASIS LICHENOIDES and parapsoriasis en plaques (small- and large-plaque parapsoriasis).	""	0	#FFFFFF
D010272	C01.610	Parasitic Diseases	Infections or infestations with PARASITES. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.	""	0	#FFFFFF
D010273	C01.610.701|C22.674	Parasitic Diseases, Animal	Animal diseases caused by PARASITES.	""	0	#FFFFFF
D010279	C19.642	Parathyroid Diseases	Pathological processes of the PARATHYROID GLANDS. They usually manifest as hypersecretion or hyposecretion of PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.	""	0	#FFFFFF
D010282	C04.588.322.525|C04.588.443.680|C19.344.525|C19.642.713	Parathyroid Neoplasms	Tumors or cancer of the PARATHYROID GLANDS.	""	0	#FFFFFF
D010283	C01.150.252.410.040.552.475.747|C22.688	Paratuberculosis	A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.	""	0	#FFFFFF
D010284	C01.150.252.400.310.821.438	Paratyphoid Fever	A prolonged febrile illness commonly caused by several Paratyphi serotypes of SALMONELLA ENTERICA. It is similar to TYPHOID FEVER but less severe.	""	0	#FFFFFF
D010291	C10.597.636|C23.888.592.643	Paresis	"A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). In the older literature, paresis often referred specifically to paretic neurosyphilis (see NEUROSYPHILIS). ""General paresis"" and ""general paralysis"" may still carry that connotation. Bilateral lower extremity paresis is referred to as PARAPARESIS."	""	0	#FFFFFF
D010292	C10.597.751.791.875|C23.888.592.763.770.875	Paresthesia	Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence of stimulation.	""	0	#FFFFFF
D010300	C10.228.140.079.862.500|C10.228.662.600.400|C10.574.928.750	Parkinson Disease	A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	""	0	#FFFFFF
D010301	C10.228.140.079.862.800.600|C10.228.662.600.700.500	Parkinson Disease, Postencephalitic	Parkinsonism following encephalitis, historically seen as a sequella of encephalitis lethargica (Von Economo Encephalitis). The early age of onset, the rapid progression of symptoms followed by stabilization, and the presence of a variety of other neurological disorders (e.g., sociopathic behavior; TICS; MUSCLE SPASMS; oculogyric crises; hyperphagia; and bizarre movements) distinguish this condition from primary PARKINSON DISEASE. Pathologic features include neuronal loss and gliosis concentrated in the MESENCEPHALON; SUBTHALAMUS; and HYPOTHALAMUS. (From Adams et al., Principles of Neurology, 6th ed, p754)	""	0	#FFFFFF
D010302	C10.228.140.079.862.800|C10.228.662.600.700	Parkinson Disease, Secondary	Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)	""	0	#FFFFFF
D010304	C01.800.460|C17.800.529.639|C17.800.838.486	Paronychia	An inflammatory reaction involving the folds of the skin surrounding the fingernail. It is characterized by acute or chronic purulent, tender, and painful swellings of the tissues around the nail, caused by an abscess of the nail fold. The pathogenic yeast causing paronychia is most frequently Candida albicans. Saprophytic fungi may also be involved. The causative bacteria are usually Staphylococcus, Pseudomonas aeruginosa, or Streptococcus. (Andrews' Diseases of the Skin, 8th ed, p271)	""	0	#FFFFFF
D010305	C07.465.815.470	Parotid Diseases	Diseases involving the PAROTID GLAND.	""	0	#FFFFFF
D010307	C04.588.443.591.824.695|C07.465.530.824.695|C07.465.815.470.770|C07.465.815.718.589	Parotid Neoplasms	Tumors or cancer of the PAROTID GLAND.	""	0	#FFFFFF
D010309	C07.465.815.470.800|C07.465.815.793.500	Parotitis	INFLAMMATION of the PAROTID GLAND.	""	0	#FFFFFF
D010310	C04.182.668|C23.300.306.500	Parovarian Cyst	A cyst (CYSTS) near the OVARY, derived from anomalies of the FALLOPIAN TUBES or the BROAD LIGAMENT. The paramesonephric type consists of ciliated cells similar to the oviduct epithelium. The mesonephric type consisted of an epithelium with minimally surface structures. They can be found on the thin oviduct (paratubal cysts) or near its fimbriated end (hydatid of Morgagni).	""	0	#FFFFFF
D010319	C22.695	Parturient Paresis	A disease of pregnant and lactating cows and ewes leading to generalized paresis and death. The disease, which is characterized by hypocalcemia, occurs at or shortly after parturition in cows and within weeks before or after parturition in ewes.	""	0	#FFFFFF
D010322	C01.925.256.700	Parvoviridae Infections	Virus infections caused by the PARVOVIRIDAE.	""	0	#FFFFFF
D010326	C01.150.252.400.700.662	Pasteurella Infections	Infections with bacteria of the genus PASTEURELLA.	""	0	#FFFFFF
D010335	C23.550	Pathologic Processes	The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs.	""	0	#FFFFFF
D010373	C01.610.858.211.465|C17.800.838.775.580	Lice Infestations	Parasitic attack or subsistence on the skin by members of the order Phthiraptera, especially on humans by Pediculus humanus of the family Pediculidae. The hair of the head, eyelashes, and pubis is a frequent site of infestation. (From Dorland, 28th ed; Stedman, 26th ed)	""	0	#FFFFFF
D010381	C15.378.553.696|C16.320.784	Pelger-Huet Anomaly	Autosomal dominant anomaly characterized by abnormal ovoid shape GRANULOCYTE nuclei and their clumping chromatin. Mutations in the LAMIN B receptor gene that results in reduced protein levels are associated with the disorder. Heterozygote individuals are healthy with normal granulocyte function while homozygote individuals occasionally have skeletal anomalies, developmental delay, and seizures.	""	0	#FFFFFF
D010382	C06.552.802|C14.907.609	Peliosis Hepatis	A vascular disease of the LIVER characterized by the occurrence of multiple blood-filled CYSTS or cavities. The cysts are lined with ENDOTHELIAL CELLS; the cavities lined with hepatic parenchymal cells (HEPATOCYTES). Peliosis hepatis has been associated with use of anabolic steroids (ANABOLIC AGENTS) and certain drugs.	""	0	#FFFFFF
D010383	C18.654.521.500.133.699.529	Pellagra	A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).	""	0	#FFFFFF
D010386	C04.588.699	Pelvic Neoplasms	Tumors or cancer of the pelvic region.	""	0	#FFFFFF
D010390	C11.187.482|C17.800.865.670	Pemphigoid, Benign Mucous Membrane	A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.	""	0	#FFFFFF
D010391	C17.800.865.690|C20.111.730	Pemphigoid, Bullous	A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.	""	0	#FFFFFF
D010392	C17.800.865.716|C20.111.736	Pemphigus	Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.	""	0	#FFFFFF
D010409	C12.100.500.494|C12.200.294.494	Penile Diseases	Pathological processes involving the PENIS or its component tissues.	""	0	#FFFFFF
D010411	C12.100.500.494.508|C12.200.294.494.508|C17.300.715	Penile Induration	A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.	""	0	#FFFFFF
D010412	C04.588.945.440.715|C12.100.500.260.500|C12.100.500.494.591|C12.200.294.260.500|C12.200.294.494.591|C12.200.758.409.500|C12.900.619.500	Penile Neoplasms	Cancers or tumors of the PENIS or of its component tissues.	""	0	#FFFFFF
D010437	C06.405.469.275.800|C06.405.748.586	Peptic Ulcer	Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	""	0	#FFFFFF
D010438	C06.405.227.700|C23.550.414.788.700	Peptic Ulcer Hemorrhage	Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.	""	0	#FFFFFF
D010439	C06.405.469.275.800.698|C06.405.748.586.698	Peptic Ulcer Perforation	Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.	""	0	#FFFFFF
D010468	C10.597.606.762|C23.888.592.604.764	Perceptual Disorders	Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense organs. These include spatial neglect syndromes, where an individual does not attend to visual, auditory, or sensory stimuli presented from one side of the body.	""	0	#FFFFFF
D010482	C01.830.025.650|C07.320.830.700.700|C07.465.714.306.700.700|C07.465.714.533.487.700	Periapical Abscess	Acute or chronic inflammation of tissues surrounding the apical portion of a tooth, associated with the collection of pus, resulting from infection following pulp infection through a carious lesion or as a result of an injury causing pulp necrosis. (Dorland, 27th ed)	""	0	#FFFFFF
D010483	C07.320.830|C07.465.714.306	Periapical Diseases	Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT.	""	0	#FFFFFF
D010484	C07.320.830.700.740|C07.465.714.306.700.740|C07.465.714.533.487.740	Periapical Granuloma	Chronic nonsuppurative inflammation of periapical tissue resulting from irritation following pulp disease or endodontic treatment.	""	0	#FFFFFF
D010485	C07.320.830.700|C07.465.714.306.700|C07.465.714.533.487	Periapical Periodontitis	Inflammation of the PERIAPICAL TISSUE. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is PERIAPICAL GRANULOMA. Suppurative inflammation is PERIAPICAL ABSCESS.	""	0	#FFFFFF
D010488	C14.907.940.090.720|C14.907.940.897.500|C17.800.862.625	Polyarteritis Nodosa	A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.	""	0	#FFFFFF
D010489	C05.550.114.678|C05.550.251.595	Periarthritis	Inflammation of the tissues around a joint. (Dorland, 27th ed)	""	0	#FFFFFF
D010490	C14.280.695	Pericardial Effusion	Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.	""	0	#FFFFFF
D010493	C14.280.720	Pericarditis	Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced. Pericarditis usually leads to PERICARDIAL EFFUSION, or CONSTRICTIVE PERICARDITIS.	""	0	#FFFFFF
D010494	C14.280.720.595	Pericarditis, Constrictive	Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.	""	0	#FFFFFF
D010495	C01.150.252.410.040.552.846.554.595|C01.190.750.595|C14.260.750.595|C14.280.720.801	Pericarditis, Tuberculous	INFLAMMATION of the sac surrounding the heart (PERICARDIUM) due to MYCOBACTERIUM TUBERCULOSIS infection. Pericarditis can lead to swelling (PERICARDIAL EFFUSION), compression of the heart (CARDIAC TAMPONADE), and preventing normal beating of the heart.	""	0	#FFFFFF
D010497	C07.465.714.258.771	Pericoronitis	Inflammation of the gingiva surrounding the crown of a tooth.	""	0	#FFFFFF
D010501	C12.050.351.968.419.685|C12.200.777.419.685|C12.950.419.685	Perinephritis	Inflammation of the connective and adipose tissues surrounding the KIDNEY.	""	0	#FFFFFF
D010505	C16.320.382.625	Familial Mediterranean Fever	A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene.	""	0	#FFFFFF
D010508	C01.830.025.665|C07.465.714.533.650	Periodontal Abscess	Localized circumscribed purulent area of inflammation in the periodontal tissue. It is a derivative of marginal periodontitis and commonly associated with suprabony and infrabony pockets and interradicular involvements, in contrast to periapical abscess which is attributable to pulp necrosis.	""	0	#FFFFFF
D010509	C04.182.089.530.690.790|C05.500.470.690.790|C07.320.450.670.513|C07.465.714.470	Periodontal Cyst	An epithelium-lined sac containing fluid; usually found at the apex of a pulp-involved tooth. The lateral type occurs less frequently along the side of the root.	""	0	#FFFFFF
D010510	C07.465.714	Periodontal Diseases	Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.	""	0	#FFFFFF
D010514	C07.465.714.533.750	Periodontal Pocket	An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.	""	0	#FFFFFF
D010518	C07.465.714.533	Periodontitis	Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)	""	0	#FFFFFF
D010520	C07.465.714.533.161	Aggressive Periodontitis	Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.	""	0	#FFFFFF
D010522	C01.160.595|C05.116.165.595	Periostitis	Inflammation of the periosteum. The condition is generally chronic, and is marked by tenderness and swelling of the bone and an aching pain. Acute periostitis is due to infection, is characterized by diffuse suppuration, severe pain, and constitutional symptoms, and usually results in necrosis. (Dorland, 27th ed)	""	0	#FFFFFF
D010523	C10.668.829	Peripheral Nervous System Diseases	Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.	""	0	#FFFFFF
D010524	C04.588.614.596|C10.551.775|C10.668.829.725	Peripheral Nervous System Neoplasms	Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)	""	0	#FFFFFF
D010532	C06.844	Peritoneal Diseases	Pathological processes involving the PERITONEUM.	""	0	#FFFFFF
D010534	C04.588.033.513|C04.588.274.780|C06.301.780|C06.844.620	Peritoneal Neoplasms	Tumors or cancer of the PERITONEUM.	""	0	#FFFFFF
D010538	C01.463.600|C06.844.640	Peritonitis	INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.	""	0	#FFFFFF
D010547	C08.381.423.694|C16.614.694	Persistent Fetal Circulation Syndrome	A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).	""	0	#FFFFFF
D010580	C04.700.633|C06.405.469.578.750|C16.320.700.667|C17.800.621.430.530.550.625	Peutz-Jeghers Syndrome	A hereditary disease caused by autosomal dominant mutations involving CHROMOSOME 19. It is characterized by the presence of INTESTINAL POLYPS, consistently in the JEJUNUM, and mucocutaneous pigmentation with MELANIN spots of the lips, buccal MUCOSA, and digits.	""	0	#FFFFFF
D010585	C15.378.553.774|C20.673.774	Phagocyte Bactericidal Dysfunction	Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.	""	0	#FFFFFF
D010591	C10.597.606.762.700|C23.550.767.700.500|C23.888.592.604.764.700|C23.888.592.612.832.500	Phantom Limb	Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30)	""	0	#FFFFFF
D010608	C07.550|C09.775	Pharyngeal Diseases	Pathological processes involving the PHARYNX.	""	0	#FFFFFF
D010610	C04.588.443.665.710|C07.550.745|C09.647.710|C09.775.549	Pharyngeal Neoplasms	Tumors or cancer of the PHARYNX.	""	0	#FFFFFF
D010612	C01.748.561|C07.550.781|C08.730.561|C09.775.649	Pharyngitis	Inflammation of the throat (PHARYNX).	""	0	#FFFFFF
D010623	C25.775.700	Phencyclidine Abuse	The misuse of phencyclidine with associated psychological symptoms and impairment in social or occupational functioning.	""	0	#FFFFFF
D010661	C10.228.140.163.100.687|C16.320.565.100.766|C16.320.565.189.687|C18.452.132.100.687|C18.452.648.100.766|C18.452.648.189.687	Phenylketonurias	A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).	""	0	#FFFFFF
D010673	C04.557.465.625.650.700.725|C04.557.580.625.650.700.725	Pheochromocytoma	A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)	""	0	#FFFFFF
D010677	C23.550.210.870.680	Philadelphia Chromosome	An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).	""	0	#FFFFFF
D010688	C12.100.500.494.684|C12.200.294.494.684	Phimosis	A condition in which the FORESKIN cannot be retracted to reveal the GLANS PENIS. It is due to tightness or narrowing of the foreskin opening.	""	0	#FFFFFF
D010689	C14.907.617.718|C14.907.940.740	Phlebitis	Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).	""	0	#FFFFFF
D010760	C18.452.750	Phosphorus Metabolism Disorders	Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.	""	0	#FFFFFF
D010787	C17.800.600	Photosensitivity Disorders	Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.	""	0	#FFFFFF
D010842	C23.888.821.825	Pica	The persistent eating of non-nutritive substances for a period of at least one month.	""	0	#FFFFFF
D010845	C08.618.085.852.850.500|C08.618.846.565.500|C10.886.425.800.750.850.500|C18.654.726.750.500.600	Obesity Hypoventilation Syndrome	HYPOVENTILATION syndrome in very obese persons with excessive ADIPOSE TISSUE around the ABDOMEN and DIAPHRAGM. It is characterized by diminished to absent ventilatory chemoresponsiveness; chronic HYPOXIA; HYPERCAPNIA; POLYCYTHEMIA; and long periods of sleep during day and night (HYPERSOMNOLENCE). It is a condition often related to OBSTRUCTIVE SLEEP APNEA but can occur separately.	""	0	#FFFFFF
D010850	C01.925.782.687	Picornaviridae Infections	Virus diseases caused by the PICORNAVIRIDAE.	""	0	#FFFFFF
D010854	C01.150.703.753|C17.800.329.992	Piedra	Either of two diseases resulting from fungal infection of the hair shafts. Black piedra occurs mainly in and on the hairs of the scalp and is caused by Piedraia hortae; white piedra occurs in and on the hairs of the scalp, beard, moustache and genital areas and is caused by Trichosporon species.	""	0	#FFFFFF
D010855	C05.500.460.606|C05.660.207.540.460.606|C07.320.440.606|C07.650.500.460.606|C16.131.621.207.540.460.606|C16.131.850.500.460.606	Pierre Robin Syndrome	Congenital malformation characterized by MICROGNATHIA or RETROGNATHIA; GLOSSOPTOSIS and CLEFT PALATE. The mandibular abnormalities often result in difficulties in sucking and swallowing. The syndrome may be isolated or associated with other syndromes (e.g., ANDERSEN SYNDROME; CAMPOMELIC DYSPLASIA). Developmental mis-expression of SOX9 TRANSCRIPTION FACTOR gene on chromosome 17q and its surrounding region is associated with the syndrome.	""	0	#FFFFFF
D010859	C17.800.621|C23.550.755	Pigmentation Disorders	Diseases affecting PIGMENTATION, including SKIN PIGMENTATION.	""	0	#FFFFFF
D010864	C04.182.710	Pilonidal Sinus	A hair-containing cyst or sinus, occurring chiefly in the coccygeal region.	""	0	#FFFFFF
D010871	C04.557.465.625.600.657|C04.557.470.670.657|C04.557.580.625.600.657|C04.588.614.250.195.766|C10.228.140.211.788|C10.551.240.250.625	Pinealoma	Neoplasms which originate from pineal parenchymal cells that tend to enlarge the gland and be locally invasive. The two major forms are pineocytoma and the more malignant pineoblastoma. Pineocytomas have moderate cellularity and tend to form rosette patterns. Pineoblastomas are highly cellular tumors containing small, poorly differentiated cells. These tumors occasionally seed the neuroaxis or cause obstructive HYDROCEPHALUS or Parinaud's syndrome. GERMINOMA; CARCINOMA, EMBRYONAL; GLIOMA; and other neoplasms may arise in the pineal region with germinoma being the most common pineal region tumor. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2064; Adams et al., Principles of Neurology, 6th ed, p670)	""	0	#FFFFFF
D010874	C01.150.252.400.794.840.250|C01.150.252.400.840.250|C01.150.252.819.630|C01.800.720.630|C17.800.838.765.630	Pinta	An infectious disease of the skin caused by Treponema carateum that occurs only in the western hemisphere. Age of onset is between 10 and 20 years of age. This condition is characterized by marked changes in the skin color and is believed to be transmitted by direct person-to-person contact.	""	0	#FFFFFF
D010899	C10.228.140.300.535.625|C10.228.140.617.738.350|C14.907.253.573.600|C19.700.725	Pituitary Apoplexy	The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.	""	0	#FFFFFF
D010900	C10.228.140.617.738|C19.700	Pituitary Diseases	Disorders involving either the ADENOHYPOPHYSIS or the NEUROHYPOPHYSIS. These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. Neoplastic pituitary masses can also cause compression of the OPTIC CHIASM and other adjacent structures.	""	0	#FFFFFF
D010911	C04.588.322.609|C04.588.614.250.195.885.500.600|C10.228.140.211.885.500.600|C10.228.140.617.477.600|C10.228.140.617.738.675|C10.551.240.250.700.500.500|C19.344.609|C19.700.734	Pituitary Neoplasms	Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.	""	0	#FFFFFF
D010915	C17.800.859.600	Pityriasis	A name originally applied to a group of skin diseases characterized by the formation of fine, branny scales, but now used only with a modifier. (Dorland, 27th ed)	""	0	#FFFFFF
D010916	C17.800.859.600.685	Pityriasis Rubra Pilaris	A chronic skin disease characterized by small follicular papules, disseminated reddish-brown scaly patches, and often, palmoplantar hyperkeratosis. The papules are about the size of a pin and topped by a horny plug.	""	0	#FFFFFF
D010921	C12.050.703.420.643|C12.050.703.590.609	Placenta Accreta	Abnormal placentation in which all or parts of the PLACENTA are attached directly to the MYOMETRIUM due to a complete or partial absence of DECIDUA. It is associated with POSTPARTUM HEMORRHAGE because of the failure of placental separation.	""	0	#FFFFFF
D010922	C12.050.703.590	Placenta Diseases	Pathological processes or abnormal functions of the PLACENTA.	""	0	#FFFFFF
D010923	C12.050.703.420.714|C12.050.703.590.734	Placenta Previa	Abnormal placentation in which the PLACENTA implants in the lower segment of the UTERUS (the zone of dilation) and may cover part or all of the opening of the CERVIX. It is often associated with serious antepartum bleeding and PREMATURE LABOR.	""	0	#FFFFFF
D010927	C12.050.703.590.800	Placental Insufficiency	Failure of the PLACENTA to deliver an adequate supply of nutrients and OXYGEN to the FETUS.	""	0	#FFFFFF
D010930	C01.150.252.400.310.980.390|C01.920.906	Plague	An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.	""	0	#FFFFFF
D010939	C25.723.756	Plant Poisoning	Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.	""	0	#FFFFFF
D010954	C04.557.595.600|C20.683.515.880	Plasmacytoma	Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.	""	0	#FFFFFF
D010981	C15.378.100.685|C15.378.140.735|C15.378.463.735	Platelet Storage Pool Deficiency	Disorder characterized by a decrease or lack of platelet dense bodies in which the releasable pool of adenine nucleotides and 5HT are normally stored.	""	0	#FFFFFF
D010985	C05.116.099.742|C05.116.900.540|C05.660.207.720|C16.131.621.207.720	Platybasia	A developmental deformity of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward. (Dorland, 27th ed)	""	0	#FFFFFF
D010995	C08.528	Pleural Diseases	Diseases involving the PLEURA.	""	0	#FFFFFF
D010996	C08.528.652	Pleural Effusion	Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.	""	0	#FFFFFF
D010997	C04.588.894.797.640|C08.528.694|C08.785.640	Pleural Neoplasms	Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.	""	0	#FFFFFF
D010998	C01.748.582|C08.528.735|C08.730.582	Pleurisy	INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.	""	0	#FFFFFF
D011000	C01.925.782.687.359.213.737	Pleurodynia, Epidemic	An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.	""	0	#FFFFFF
D011001	C01.748.582.473|C01.748.610.473|C08.381.677.473|C08.528.735.473|C08.730.582.473|C08.730.610.473	Pleuropneumonia	Inflammation of the lung parenchyma that is associated with PLEURISY, inflammation of the PLEURA.	""	0	#FFFFFF
D011002	C01.150.252.400.610.610.717|C22.717	Pleuropneumonia, Contagious	A pleuropneumonia of cattle and goats caused by species of MYCOPLASMA.	""	0	#FFFFFF
D011004	C06.405.117.119.500.742	Plummer-Vinson Syndrome	A syndrome of DYSPHAGIA with IRON-DEFICIENCY ANEMIA that is due to congenital anomalies in the ESOPHAGUS (such as cervical esophageal webs). It is known as Patterson-Kelly syndrome in the United Kingdom.	""	0	#FFFFFF
D011006	C06.405.469.778	Pneumatosis Cystoides Intestinalis	A condition characterized by the presence of multiple gas-filled cysts in the intestinal wall, the submucosa and/or subserosa of the INTESTINE. The majority of the cysts are found in the JEJUNUM and the ILEUM.	""	0	#FFFFFF
D011007	C10.228.140.199.700|C10.228.806|C10.900.300.087.700|C26.915.300.200.650	Pneumocephalus	Presence of air or gas within the intracranial cavity (e.g., epidural space, subdural space, intracerebral, etc.) which may result from traumatic injuries, fistulous tract formation, erosions of the skull from NEOPLASMS or infection, NEUROSURGICAL PROCEDURES, and other conditions.	""	0	#FFFFFF
D011008	C01.150.252.410.890.670	Pneumococcal Infections	Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.	""	0	#FFFFFF
D011009	C08.381.483.581|C08.381.520.702|C24.800	Pneumoconiosis	A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.	""	0	#FFFFFF
D011014	C01.748.610|C08.381.677|C08.730.610	Pneumonia	Infection of the lung often accompanied by inflammation.	""	0	#FFFFFF
D011015	C01.748.610.529|C08.381.677.529|C08.730.610.529	Pneumonia, Aspiration	A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.	""	0	#FFFFFF
D011016	C22.196.706	Pneumonia, Atypical Interstitial, of Cattle	A cattle disease of uncertain cause, probably an allergic reaction.	""	0	#FFFFFF
D011017	C01.748.610.529.612|C08.381.677.529.612|C08.730.610.529.612	Pneumonia, Lipid	Pneumonia due to aspiration or inhalation of various oily or fatty substances.	""	0	#FFFFFF
D011018	C01.150.252.410.890.670.750|C01.150.252.620.550|C01.748.610.540.550|C08.381.677.540.550|C08.730.610.540.550	Pneumonia, Pneumococcal	A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.	""	0	#FFFFFF
D011019	C01.150.252.400.610.610.760|C01.150.252.620.500|C01.748.610.540.545|C08.381.677.540.500|C08.730.610.540.545	Pneumonia, Mycoplasma	Interstitial pneumonia caused by extensive infection of the lungs (LUNG) and BRONCHI, particularly the lower lobes of the lungs, by MYCOPLASMA PNEUMONIAE in humans. In SHEEP, it is caused by MYCOPLASMA OVIPNEUMONIAE. In CATTLE, it may be caused by MYCOPLASMA DISPAR.	""	0	#FFFFFF
D011020	C01.150.703.534.700|C01.150.703.770.700|C01.748.435.700|C01.748.610.675|C08.381.472.700|C08.381.677.675|C08.730.435.700|C08.730.610.675	Pneumonia, Pneumocystis	A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.	""	0	#FFFFFF
D011021	C01.925.782.815.616.660|C01.925.839.660|C22.836.660	Pneumonia, Progressive Interstitial, of Sheep	Chronic respiratory disease caused by the VISNA-MAEDI VIRUS. It was formerly believed to be identical with jaagsiekte (PULMONARY ADENOMATOSIS, OVINE) but is now recognized as a separate entity.	""	0	#FFFFFF
D011022	C01.150.252.400.789.600|C01.748.610.540.600|C01.920.914.600|C08.381.677.540.600|C08.730.610.540.600	Pneumonia, Rickettsial	Pneumonia caused by infection with bacteria of the family RICKETTSIACEAE.	""	0	#FFFFFF
D011023	C01.150.252.410.868.675|C01.150.252.620.620|C01.748.610.540.620|C08.381.677.540.620|C08.730.610.540.620	Pneumonia, Staphylococcal	Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.	""	0	#FFFFFF
D011024	C01.748.610.763|C01.925.705|C08.381.677.807|C08.730.610.763	Pneumonia, Viral	Inflammation of the lung parenchyma that is caused by a viral infection.	""	0	#FFFFFF
D011026	C14.280.763	Pneumopericardium	Presence of air or gas in the space between the heart and the PERICARDIUM. The degree of respiratory distress depends on the amount of trapped air and circulation blocked in the systemic and pulmonary veins.	""	0	#FFFFFF
D011027	C06.844.670	Pneumoperitoneum	A condition with trapped gas or air in the PERITONEAL CAVITY, usually secondary to perforation of the internal organs such as the LUNG and the GASTROINTESTINAL TRACT, or to recent surgery. Pneumoperitoneum may be purposely introduced to aid radiological examination.	""	0	#FFFFFF
D011030	C08.528.778	Pneumothorax	An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.	""	0	#FFFFFF
D011038	C16.131.831.775|C16.320.850.765|C16.614.760|C17.800.804.775|C17.800.827.775|C18.452.284.760	Rothmund-Thomson Syndrome	An autosomal recessive syndrome occurring principally in females, characterized by the presence of reticulated, atrophic, hyperpigmented, telangiectatic cutaneous plaques, often accompanied by juvenile cataracts, saddle nose, congenital bone defects, disturbances in the growth of HAIR; NAILS; and TEETH; and HYPOGONADISM.	""	0	#FFFFFF
D011040	C17.800.174.255.100.700|C17.800.815.255.100.700|C20.543.418.150.700	Dermatitis, Toxicodendron	An allergic contact dermatitis caused by exposure to plants of the genus Toxicodendron (formerly Rhus). These include poison ivy, poison oak, and poison sumac, all plants that contain the substance urushiol, a potent skin sensitizing agent. (From Dorland, 27th ed)	""	0	#FFFFFF
D011041	C25.723	Poisoning	A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.	""	0	#FFFFFF
D011045	C05.116.099.370.894.819.756|C05.660.585.800.756|C05.660.906.819.756|C16.131.621.585.800.756|C16.131.621.906.819.756	Poland Syndrome	A syndrome which is characterized by symbrachydactyly and aplasia of the sternal head of pectoralis major.	""	0	#FFFFFF
D011051	C01.207.618.750|C01.925.782.687.359.764|C10.228.228.618.750|C10.228.854.525.850|C10.586.750.850|C10.668.864	Poliomyelitis	An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	""	0	#FFFFFF
D011052	C01.207.618.750.500|C01.925.782.687.359.764.614|C10.228.228.618.750.500|C10.228.854.525.850.500|C10.586.750.850.500|C10.668.864.250	Poliomyelitis, Bulbar	A form of paralytic poliomyelitis affecting neurons of the MEDULLA OBLONGATA of the brain stem. Clinical features include impaired respiration, HYPERTENSION, alterations of vasomotor control, and dysphagia. Weakness and atrophy of the limbs and trunk due to spinal cord involvement is usually associated. (From Adams et al., Principles of Neurology, 6th ed, p765)	""	0	#FFFFFF
D011081	C05.182.531|C17.300.182.531	Polychondritis, Relapsing	An acquired disease of unknown etiology, chronic course, and tendency to recur. It is characterized by inflammation and degeneration of cartilage and can result in deformities such as floppy ear and saddle nose. Loss of cartilage in the respiratory tract can lead to respiratory obstruction.	""	0	#FFFFFF
D011085	C04.182.612.765|C12.050.351.500.056.630.580.765|C12.100.250.056.630.580.765|C19.391.630.580.765	Polycystic Ovary Syndrome	A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.	""	0	#FFFFFF
D011086	C15.378.738	Polycythemia	An increase in the total red cell mass of the blood. (Dorland, 27th ed)	""	0	#FFFFFF
D011087	C04.588.448.200.500|C15.378.190.250.500|C15.378.190.636.753|C15.378.400.200.500	Polycythemia Vera	A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.	""	0	#FFFFFF
D011111	C05.651.742|C05.799.720|C17.300.775.720	Polymyalgia Rheumatica	A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.	""	0	#FFFFFF
D011115	C10.668.829.800	Polyneuropathies	Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.	""	0	#FFFFFF
D011123	C23.550.210.702	Polyploidy	The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.	""	0	#FFFFFF
D011125	C04.557.470.035.215.100|C04.588.274.476.411.307.089|C04.700.100|C06.301.371.411.307.090|C06.405.249.411.307.090|C06.405.469.158.356.090|C06.405.469.491.307.090|C06.405.469.578.249|C16.320.700.100	Adenomatous Polyposis Coli	A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.	""	0	#FFFFFF
D011127	C23.300.825	Polyps	Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.	""	0	#FFFFFF
D011128	C10.668.829.800.750.700	Polyradiculopathy	Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.	""	0	#FFFFFF
D011129	C10.114.750|C10.314.750|C10.668.829.800.750|C20.111.258.750	Polyradiculoneuropathy	Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.	""	0	#FFFFFF
D011141	C12.050.351.968.934.616|C12.200.777.934.616|C12.950.934.616|C23.888.942.600	Polyuria	Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).	""	0	#FFFFFF
D011146	C17.800.174.620.300|C17.800.815.620.300|C17.800.865.385	Eczema, Dyshidrotic	A recurrent eczematous reaction characterized by the development of vesicular eruptions on the palms and soles, particularly along the sides and between the digits. It is accompanied by pruritus, a burning sensation, and hyperhidrosis. The disease is self-limiting, lasting only a few weeks. (Dorland, 27th ed)	""	0	#FFFFFF
D011151	C04.182.867.500	Popliteal Cyst	A SYNOVIAL CYST located in the back of the knee, in the popliteal space arising from the semimembranous bursa or the knee joint.	""	0	#FFFFFF
D011164	C18.452.811	Porphyrias	A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.	""	0	#FFFFFF
D011178	C06.405.748.630|C23.550.767.812	Postgastrectomy Syndromes	Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.	""	0	#FFFFFF
D011180	C23.550.260.224.617	Postmortem Changes	Physiological changes that occur in bodies after death.	""	0	#FFFFFF
D011183	C23.550.767	Postoperative Complications	Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	""	0	#FFFFFF
D011185	C14.280.793|C23.550.767.863	Postpericardiotomy Syndrome	A nonspecific hypersensitivity reaction caused by TRAUMA to the PERICARDIUM, often following PERICARDIOTOMY. It is characterized by PERICARDIAL EFFUSION; high titers of anti-heart antibodies; low-grade FEVER; LETHARGY; loss of APPETITE; or ABDOMINAL PAIN.	""	0	#FFFFFF
D011186	C14.907.617.718.760|C14.907.952.760	Postphlebitic Syndrome	A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous VARICOSE VEINS are usually present. Leg pain may occur after long period of standing.	""	0	#FFFFFF
D011191	C18.654.521.500.617	Potassium Deficiency	A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)	""	0	#FFFFFF
D011201	C22.131.728	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	""	0	#FFFFFF
D011213	C01.925.256.743	Poxviridae Infections	Virus diseases caused by the POXVIRIDAE.	""	0	#FFFFFF
D011218	C10.597.606.360.690|C16.131.077.730|C16.131.260.700|C16.320.180.700|C18.654.726.750.500.740	Prader-Willi Syndrome	An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)	""	0	#FFFFFF
D011225	C12.050.703.395.249	Pre-Eclampsia	A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.	""	0	#FFFFFF
D011226	C14.280.067.780|C14.280.123.750	Pre-Excitation Syndromes	A group of conditions in which HEART VENTRICLE activation by the atrial impulse is faster than the normal impulse conduction from the SINOATRIAL NODE. In these pre-excitation syndromes, atrial impulses often bypass the ATRIOVENTRICULAR NODE delay and travel via ACCESSORY CONDUCTING PATHWAYS connecting the atrium directly to the BUNDLE OF HIS.	""	0	#FFFFFF
D011227	C14.280.067.780.770|C14.280.123.750.770	Pre-Excitation, Mahaim-Type	A form of ventricular pre-excitation characterized by a normal PR interval and a long QRS interval with an initial slow deflection (delta wave). In this syndrome, the atrial impulse travel to the ventricle via the MAHAIM FIBERS which connect ATRIOVENTRICULAR NODE directly to the right ventricle wall (NODOVENTRICULAR ACCESSORY PATHWAY) or to the RIGHT BUNDLE BRANCH OF HIS (nodofascicular accessory pathway).	""	0	#FFFFFF
D011230	C04.834	Precancerous Conditions	Pathological conditions that tend eventually to become malignant.	""	0	#FFFFFF
D011236	C18.452.394.750.774|C19.246.774	Prediabetic State	The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).	""	0	#FFFFFF
D011248	C12.050.703	Pregnancy Complications	Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.	""	0	#FFFFFF
D011249	C12.050.703.634|C14.583	Pregnancy Complications, Cardiovascular	The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.	""	0	#FFFFFF
D011250	C12.050.703.667|C15.378.785	Pregnancy Complications, Hematologic	The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.	""	0	#FFFFFF
D011251	C01.674|C12.050.703.700	Pregnancy Complications, Infectious	The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.	""	0	#FFFFFF
D011252	C04.850|C12.050.703.720	Pregnancy Complications, Neoplastic	The co-occurrence of pregnancy and NEOPLASMS. The neoplastic disease may precede or follow FERTILIZATION.	""	0	#FFFFFF
D011254	C12.050.703.726	Pregnancy in Diabetics	The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.	""	0	#FFFFFF
D011269	C12.050.703.733.536	Pregnancy, Abdominal	A type of ectopic pregnancy in which the EMBRYO, MAMMALIAN implants in the ABDOMINAL CAVITY instead of in the ENDOMETRIUM of the UTERUS.	""	0	#FFFFFF
D011271	C12.050.703.733	Pregnancy, Ectopic	A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).	""	0	#FFFFFF
D011273	C12.050.703.805	Pregnancy, Prolonged	A term used to describe pregnancies that exceed the upper limit of a normal gestational period. In humans, a prolonged pregnancy is defined as one that extends beyond 42 weeks (294 days) after the first day of the last menstrual period (MENSTRUATION), or birth with gestational age of 41 weeks or more.	""	0	#FFFFFF
D011274	C12.050.703.733.703	Pregnancy, Tubal	The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.	""	0	#FFFFFF
D011289	C04.834.770|C15.378.800	Preleukemia	Conditions in which the abnormalities in the peripheral blood or bone marrow represent the early manifestations of acute leukemia, but in which the changes are not of sufficient magnitude or specificity to permit a diagnosis of acute leukemia by the usual clinical criteria.	""	0	#FFFFFF
D011293	C23.550.568.968	Premenstrual Syndrome	A combination of distressing physical, psychologic, or behavioral changes that occur during the luteal phase of the menstrual cycle. Symptoms of PMS are diverse (such as pain, water-retention, anxiety, cravings, and depression) and they diminish markedly 2 or 3 days after the initiation of menses.	""	0	#FFFFFF
D011297	C12.050.703.824.500	Prenatal Exposure Delayed Effects	The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.	""	0	#FFFFFF
D011304	C09.218.458.341.887.772|C10.597.751.418.341.887.772|C23.888.592.763.393.341.887.772	Presbycusis	Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.	""	0	#FFFFFF
D011305	C11.744.786	Presbyopia	The normal decreasing elasticity of the crystalline lens that leads to loss of accommodation.	""	0	#FFFFFF
D011317	C12.100.500.494.786|C12.200.294.494.786	Priapism	A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE CELL ANEMIA, advanced malignancy, spinal trauma; and certain drug treatments.	""	0	#FFFFFF
D011349	C06.405.205.865|C06.405.469.860.622	Proctitis	INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).	""	0	#FFFFFF
D011350	C06.405.205.265.767|C06.405.205.865.790|C06.405.469.158.188.767|C06.405.469.158.850.790|C06.405.469.860.622.790	Proctocolitis	Inflammation of the RECTUM and the distal portion of the COLON.	""	0	#FFFFFF
D011371	C16.320.488.875|C16.320.565.753|C18.452.648.753	Progeria	An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.	""	0	#FFFFFF
D011378	C05.500.460.655|C05.500.607.655|C05.660.207.540.460.655|C07.320.440.655|C07.320.610.655|C07.650.500.460.655|C16.131.621.207.540.460.655|C16.131.850.500.460.655	Prognathism	A condition marked by abnormal protrusion of the mandible. (Dorland, 27th ed)	""	0	#FFFFFF
D011391	C23.300.842	Prolapse	The protrusion of an organ or part of an organ into a natural or artificial orifice.	""	0	#FFFFFF
D011469	C12.100.500.565|C12.200.294.565	Prostatic Diseases	Pathological processes involving the PROSTATE or its component tissues.	""	0	#FFFFFF
D011470	C12.100.500.565.500|C12.200.294.565.500	Prostatic Hyperplasia	Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.	""	0	#FFFFFF
D011471	C04.588.945.440.770|C12.100.500.260.750|C12.100.500.565.625|C12.200.294.260.750|C12.200.294.565.625|C12.200.758.409.750|C12.900.619.750	Prostatic Neoplasms	Tumors or cancer of the PROSTATE.	""	0	#FFFFFF
D011472	C12.100.500.565.750|C12.200.294.565.750	Prostatitis	Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.	""	0	#FFFFFF
D011475	C23.550.767.865	Prosthesis Failure	Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.	""	0	#FFFFFF
D011488	C18.654.521.500.708	Protein Deficiency	A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406)	""	0	#FFFFFF
D011502	C18.654.521.500.708.626	Protein-Energy Malnutrition	The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.	""	0	#FFFFFF
D011504	C06.405.469.818	Protein-Losing Enteropathies	Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE.	""	0	#FFFFFF
D011507	C12.050.351.968.934.734|C12.200.777.934.734|C12.950.934.734|C23.888.942.750	Proteinuria	The presence of proteins in the urine, an indicator of KIDNEY DISEASES.	""	0	#FFFFFF
D011512	C01.150.252.400.310.708	Proteus Infections	Infections with bacteria of the genus PROTEUS.	""	0	#FFFFFF
D011528	C01.610.752	Protozoan Infections	Infections with unicellular organisms formerly members of the subkingdom Protozoa.	""	0	#FFFFFF
D011529	C01.610.701.688|C01.610.752.625|C22.674.710	Protozoan Infections, Animal	Infections with unicellular organisms formerly members of the subkingdom Protozoa. The infections may be experimental or veterinary.	""	0	#FFFFFF
D011535	C16.131.077.745	Prune Belly Syndrome	A syndrome characterized by abdominal wall musculature deficiency, cryptorchism, and urinary tract abnormalities. The syndrome derives its name from its characteristic distended abdomen with wrinkled skin.	""	0	#FFFFFF
D011536	C17.800.674	Prurigo	A name applied to several itchy skin eruptions of unknown cause. The characteristic course is the formation of a dome-shaped papule with a small transient vesicle on top, followed by crusting over or lichenification. (From Dorland, 27th ed)	""	0	#FFFFFF
D011537	C17.800.685|C23.888.885.625	Pruritus	An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	""	0	#FFFFFF
D011538	C06.405.469.860.101.752|C17.800.685.544	Pruritus Ani	Intense chronic itching in the anal area.	""	0	#FFFFFF
D011539	C12.050.351.500.944.626|C12.100.250.944.626|C17.800.685.710	Pruritus Vulvae	Intense itching of the external female genitals.	""	0	#FFFFFF
D011542	C26.404.468.627	Pseudarthrosis	"A pathologic entity characterized by deossification of a weight-bearing long bone, followed by bending and pathologic fracture, with inability to form normal BONY CALLUS leading to existence of the ""false joint"" that gives the condition its name. (Dorland, 27th ed)"	""	0	#FFFFFF
D011546	C12.050.351.968.419.815.770|C12.200.777.419.815.770|C12.950.419.815.770|C16.320.831.770	Pseudohypoaldosteronism	A heterogeneous group of disorders characterized by renal electrolyte transport dysfunctions. Congenital forms are rare autosomal disorders characterized by neonatal hypertension, HYPERKALEMIA, increased RENIN activity and ALDOSTERONE concentration. The Type I features HYPERKALEMIA with sodium wasting; Type II, HYPERKALEMIA without sodium wasting. Pseudohypoaldosteronism can be the result of a defective renal electrolyte transport protein or acquired after KIDNEY TRANSPLANTATION.	""	0	#FFFFFF
D011547	C05.116.198.709|C16.320.565.618.815|C18.452.104.709|C18.452.174.766|C18.452.648.618.815	Pseudohypoparathyroidism	A hereditary syndrome clinically similar to HYPOPARATHYROIDISM. It is characterized by HYPOCALCEMIA; HYPERPHOSPHATEMIA; and associated skeletal development impairment and caused by failure of response to PARATHYROID HORMONE rather than deficiencies. A severe form with resistance to multiple hormones is referred to as Type 1a and is associated with maternal mutant allele of the ALPHA CHAIN OF STIMULATORY G PROTEIN.	""	0	#FFFFFF
D011552	C01.150.252.400.739	Pseudomonas Infections	Infections with bacteria of the genus PSEUDOMONAS.	""	0	#FFFFFF
D011553	C04.557.470.200.025.075.500|C04.557.470.590.075.500	Pseudomyxoma Peritonei	A peritoneal adenocarcinoma characterized by build-up of MUCUS in the PERITONEAL CAVITY. Mucus secreting cells may attach to the peritoneal lining and continue to secrete mucus. The majority of cases represent tumor spread from a primary low-grade mucinous neoplasm of the APPENDIX (NCI Thesaurus).	""	0	#FFFFFF
D011556	C05.116.198.709.628|C16.320.565.618.815.815|C18.452.104.709.628|C18.452.174.766.815|C18.452.648.618.815.815	Pseudopseudohypoparathyroidism	A form of PSEUDOHYPOPARATHYROIDISM characterized by the same features except for the abnormal response to hormones such as PARATHYROID HORMONE. It is associated with paternally inherited mutant alleles of the ALPHA CHAIN OF STIMULATORY G PROTEIN.	""	0	#FFFFFF
D011557	C01.207.245.710|C01.925.182.710|C01.925.256.466.793|C10.228.228.245.710|C22.742	Pseudorabies	A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals.	""	0	#FFFFFF
D011559	C10.228.140.631.750	Pseudotumor Cerebri	A condition marked by raised intracranial pressure and characterized clinically by HEADACHES; NAUSEA; PAPILLEDEMA, peripheral constriction of the visual fields, transient visual obscurations, and pulsatile TINNITUS. OBESITY is frequently associated with this condition, which primarily affects women between 20 and 44 years of age. Chronic PAPILLEDEMA may lead to optic nerve injury (see OPTIC NERVE DISEASES) and visual loss (see BLINDNESS).	""	0	#FFFFFF
D011561	C14.907.454.530|C15.378.463.515.530|C16.131.831.766|C16.320.850.750|C17.300.766|C17.800.804.766|C17.800.827.750	Pseudoxanthoma Elasticum	An inherited disorder of connective tissue with extensive degeneration and calcification of ELASTIC TISSUE primarily in the skin, eye, and vasculature. At least two forms exist, autosomal recessive and autosomal dominant. This disorder is caused by mutations of one of the ATP-BINDING CASSETTE TRANSPORTERS. Patients are predisposed to MYOCARDIAL INFARCTION and GASTROINTESTINAL HEMORRHAGE.	""	0	#FFFFFF
D011565	C17.800.859.675	Psoriasis	A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	""	0	#FFFFFF
D011595	C10.597.350.600|C10.597.606.881.700|C23.888.592.350.600|C23.888.592.604.882.700	Psychomotor Agitation	A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.	""	0	#FFFFFF
D011596	C10.597.606.881|C23.888.592.604.882	Psychomotor Disorders	Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.	""	0	#FFFFFF
D011602	C23.888.592.700	Psychophysiologic Disorders	A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)	""	0	#FFFFFF
D011604	C25.723.809.750|C25.775.100.087.750	Psychoses, Alcoholic	A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.	""	0	#FFFFFF
D011605	C25.723.809|C25.775.746	Psychoses, Substance-Induced	Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.	""	0	#FFFFFF
D011625	C11.187.781	Pterygium	An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)	""	0	#FFFFFF
D011628	C19.391.690	Puberty, Delayed	The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.	""	0	#FFFFFF
D011629	C19.391.693	Puberty, Precocious	Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.	""	0	#FFFFFF
D011644	C12.050.703.844	Puerperal Disorders	Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.	""	0	#FFFFFF
D011645	C01.674.715|C12.050.703.700.715|C12.050.703.844.757	Puerperal Infection	An infection occurring in PUERPERIUM, the period of 6-8 weeks after giving birth.	""	0	#FFFFFF
D011648	C01.925.782.815.725|C01.925.928.740|C04.557.470.200.025.715|C22.836.715	Pulmonary Adenomatosis, Ovine	A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.	""	0	#FFFFFF
D011649	C08.381.719	Pulmonary Alveolar Proteinosis	A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.	""	0	#FFFFFF
D011654	C08.381.742	Pulmonary Edema	Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	""	0	#FFFFFF
D011655	C08.381.746|C14.907.355.350.700	Pulmonary Embolism	Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.	""	0	#FFFFFF
D011656	C08.381.495.389.750|C23.550.291.500.875.875	Pulmonary Emphysema	Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.	""	0	#FFFFFF
D011657	C08.381.750|C15.378.553.231.549.750	Pulmonary Eosinophilia	A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.	""	0	#FFFFFF
D011658	C08.381.483.652|C23.550.355.644	Pulmonary Fibrosis	A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.	""	0	#FFFFFF
D011660	C14.280.832	Pulmonary Heart Disease	Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.	""	0	#FFFFFF
D011662	C14.280.484.716.762|C14.280.955.750.762	Pulmonary Subvalvular Stenosis	Narrowing below the PULMONARY VALVE or well below it in the infundibuluar chamber where the pulmonary artery originates, usually caused by a defective VENTRICULAR SEPTUM or presence of fibrous tissues. It is characterized by restricted blood outflow from the RIGHT VENTRICLE into the PULMONARY ARTERY, exertional fatigue, DYSPNEA, and chest discomfort.	""	0	#FFFFFF
D011665	C14.280.484.660	Pulmonary Valve Insufficiency	Backflow of blood from the PULMONARY ARTERY into the RIGHT VENTRICLE due to imperfect closure of the PULMONARY VALVE.	""	0	#FFFFFF
D011666	C14.280.484.716|C14.280.955.750	Pulmonary Valve Stenosis	The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.	""	0	#FFFFFF
D011668	C08.381.780|C14.907.690	Pulmonary Veno-Occlusive Disease	Pathological process resulting in the fibrous obstruction of the small- and medium-sized PULMONARY VEINS and PULMONARY HYPERTENSION. Veno-occlusion can arise from fibrous proliferation of the VASCULAR INTIMA and VASCULAR MEDIA; THROMBOSIS; or a combination of both.	""	0	#FFFFFF
D011671	C07.793.237.820	Pulpitis	Inflammation of the DENTAL PULP, usually due to bacterial infection in dental caries, tooth fracture, or other conditions causing exposure of the pulp to bacterial invasion. Chemical irritants, thermal factors, hyperemic changes, and other factors may also cause pulpitis.	""	0	#FFFFFF
D011681	C10.597.690|C11.710|C23.888.592.708	Pupil Disorders	Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.	""	0	#FFFFFF
D011686	C16.320.565.798|C18.452.648.798	Purine-Pyrimidine Metabolism, Inborn Errors	Dysfunctions in the metabolism of PURINES or PYRIMIDINES resulting from inborn genetic mutations that are inherited or acquired in utero.	""	0	#FFFFFF
D011693	C15.378.100.802|C23.550.414.950|C23.888.885.687	Purpura	Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).	""	0	#FFFFFF
D011694	C14.907.454.550|C15.378.100.802.250|C15.378.463.515.550|C23.550.414.950.250|C23.888.885.687.250	Purpura, Hyperglobulinemic	Purplish or brownish red discoloration of the skin associated with increase in circulating polyclonal globulins, usually GAMMA-GLOBULINS. This syndrome often occurs on the legs of women aged 20 to 40 years.	""	0	#FFFFFF
D011695	C14.907.940.777|C15.378.100.802.375|C15.378.463.515.580|C20.543.520.600|C23.550.414.950.375|C23.888.885.687.375	IgA Vasculitis	A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.	""	0	#FFFFFF
D011696	C15.378.100.802.687|C15.378.140.855.925.750|C20.841|C23.550.414.950.687|C23.888.885.687.687	Purpura, Thrombocytopenic	Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.	""	0	#FFFFFF
D011697	C15.378.100.802.687.680|C15.378.140.855.925.750.680|C15.378.925.850|C23.550.414.950.687.680|C23.888.885.687.687.680	Purpura, Thrombotic Thrombocytopenic	An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases.	""	0	#FFFFFF
D011702	C12.050.351.968.419.570.821|C12.200.777.419.570.821|C12.950.419.570.821	Pyelitis	Inflammation of the KIDNEY PELVIS and KIDNEY CALICES where urine is collected before discharge, but does not involve the renal parenchyma (the NEPHRONS) where urine is processed.	""	0	#FFFFFF
D011704	C12.050.351.968.419.570.643.790|C12.050.351.968.419.570.821.717|C12.200.777.419.570.643.790|C12.200.777.419.570.821.717|C12.950.419.570.643.790|C12.950.419.570.821.717	Pyelonephritis	Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.	""	0	#FFFFFF
D011705	C12.050.351.968.419.570.643.790.810|C12.050.351.968.419.570.821.717.810|C12.200.777.419.570.643.790.810|C12.200.777.419.570.821.717.810|C12.950.419.570.643.790.810|C12.950.419.570.821.717.810	Pyelonephritis, Xanthogranulomatous	A chronic inflammatory condition of the KIDNEY resulting in diffuse renal destruction, a grossly enlarged and nonfunctioning kidney associated with NEPHROLITHIASIS and KIDNEY STONES.	""	0	#FFFFFF
D011707	C06.405.748.340.690	Pyloric Stenosis	Narrowing of the pyloric canal with varied etiology. A common form is due to muscle hypertrophy (PYLORIC STENOSIS, HYPERTROPHIC) seen in infants.	""	0	#FFFFFF
D011711	C17.800.695	Pyoderma	Any purulent skin disease (Dorland, 27th ed).	""	0	#FFFFFF
D011776	C01.915.719|C12.050.351.968.892.719|C12.200.777.892.719|C12.950.892.719	Pyuria	The presence of white blood cells (LEUKOCYTES) in the urine. It is often associated with bacterial infections of the urinary tract. Pyuria without BACTERIURIA can be caused by TUBERCULOSIS, stones, or cancer.	""	0	#FFFFFF
D011778	C01.150.252.400.755	Q Fever	An acute infectious disease caused by COXIELLA BURNETII. It is characterized by a sudden onset of FEVER; HEADACHE; malaise; and weakness. In humans, it is commonly contracted by inhalation of infected dusts derived from infected domestic animals (ANIMALS, DOMESTIC).	""	0	#FFFFFF
D011782	C10.597.622.760|C23.888.592.636.786	Quadriplegia	Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.	""	0	#FFFFFF
D011818	C01.925.782.580.830.750	Rabies	Acute VIRAL CNS INFECTION affecting mammals, including humans. It is caused by RABIES VIRUS and usually spread by contamination with virus-laden saliva of bites inflicted by rabid animals. Important animal vectors include the dog, cat, bat, fox, raccoon, skunk, and wolf.	""	0	#FFFFFF
D011832	C26.733	Radiation Injuries	Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.	""	0	#FFFFFF
D011833	C26.733.720	Radiation Injuries, Experimental	Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.	""	0	#FFFFFF
D011842	C04.182.089.530.690.790.820|C05.500.470.690.790.820|C07.320.450.670.513.811|C07.320.830.820|C07.465.714.306.820	Radicular Cyst	Slow-growing fluid-filled epithelial sac at the apex of a tooth with a nonvital pulp or defective root canal filling.	""	0	#FFFFFF
D011843	C10.668.829.820	Radiculopathy	Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.	""	0	#FFFFFF
D011855	C17.800.174.826|C26.733.804	Radiodermatitis	A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.	""	0	#FFFFFF
D011885	C26.088.268.556|C26.404.562	Radius Fractures	Fractures of the RADIUS.	""	0	#FFFFFF
D011900	C04.182.766|C07.465.780	Ranula	A form of retention cyst of the floor of the mouth, usually due to obstruction of the ducts of the submaxillary or sublingual glands, presenting a slowly enlarging painless deep burrowing mucocele of one side of the mouth. It is also called sublingual cyst and sublingual ptyalocele.	""	0	#FFFFFF
D011906	C01.150.252.400.771	Rat-Bite Fever	A syndrome characterized by recurring fever, rash, and arthralgias occurring days to weeks after a rat bite. The causative agents are either Streptobacillus moniliformis or Spirillum minus.	""	0	#FFFFFF
D011928	C14.907.617.812	Raynaud Disease	An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.	""	0	#FFFFFF
D012001	C09.218.458.505|C10.597.751.418.505|C23.888.592.763.393.505	Hyperacusis	An abnormally disproportionate increase in the sensation of loudness in response to auditory stimuli of normal volume. COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; FACIAL NERVE DISEASES; STAPES SURGERY; and other disorders may be associated with this condition.	""	0	#FFFFFF
D012002	C06.405.469.860	Rectal Diseases	Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).	""	0	#FFFFFF
D012003	C06.267.550.600|C06.405.469.471.600|C06.405.469.860.752|C23.300.575.185.550.600	Rectal Fistula	An abnormal anatomical passage connecting the RECTUM to the outside, with an orifice at the site of drainage.	""	0	#FFFFFF
D012004	C04.588.274.476.411.307.790|C06.301.371.411.307.790|C06.405.249.411.307.790|C06.405.469.491.307.790|C06.405.469.860.180.500	Rectal Neoplasms	Tumors or cancer of the RECTUM.	""	0	#FFFFFF
D012005	C06.405.469.860.800|C23.300.842.624.500	Rectal Prolapse	Protrusion of the rectal mucous membrane through the anus. There are various degrees: incomplete with no displacement of the anal sphincter muscle; complete with displacement of the anal sphincter muscle; complete with no displacement of the anal sphincter muscle but with herniation of the bowel; and internal complete with rectosigmoid or upper rectum intussusception into the lower rectum.	""	0	#FFFFFF
D012006	C06.267.550.600.650|C06.405.469.471.600.650|C06.405.469.860.752.650|C12.050.351.500.894.767.249|C12.100.250.894.767.249|C23.300.575.185.550.600.650|C23.300.575.925.558	Rectovaginal Fistula	An abnormal anatomical passage between the RECTUM and the VAGINA.	""	0	#FFFFFF
D012008	C23.550.291.937	Recurrence	The return of a sign, symptom, or disease after a remission.	""	0	#FFFFFF
D012010	C15.378.071.750	Red-Cell Aplasia, Pure	Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.	""	0	#FFFFFF
D012019	C10.177.195.800|C10.668.829.250.800	Reflex Sympathetic Dystrophy	A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone without an associated specific nerve injury. This condition is most often precipitated by trauma to soft tissue or nerve complexes. The skin over the affected region is usually erythematous and demonstrates hypersensitivity to tactile stimuli and erythema. (Adams et al., Principles of Neurology, 6th ed, p1360; Pain 1995 Oct;63(1):127-33)	""	0	#FFFFFF
D012021	C10.597.704|C23.888.592.717	Reflex, Abnormal	An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.	""	0	#FFFFFF
D012030	C11.744	Refractive Errors	Deviations from the average or standard indices of refraction of the eye through its dioptric or refractive apparatus.	""	0	#FFFFFF
D012035	C10.228.140.163.100.813|C10.500.300.780|C10.574.500.495.780|C10.668.829.800.300.780|C16.131.666.300.780|C16.320.400.375.780|C16.320.565.189.813|C16.320.565.663.760|C18.452.132.100.813|C18.452.648.189.813|C18.452.648.663.760	Refsum Disease	An autosomal recessive familial disorder that usually presents in childhood with POLYNEUROPATHY; SENSORINEURAL HEARING LOSS; ICHTHYOSIS; ATAXIA; RETINITIS PIGMENTOSA; and CARDIOMYOPATHIES. (From Joynt, Clinical Neurology, 1991, Ch37, p58-9; Rev Med Interne 1996;17(5):391-8) This condition can be caused by mutation in the genes encoding peroxisomal phytanoyl-CoA hydroxylase or proteins associated peroxisomal membrane, leading to impaired catabolism of PHYTANIC ACID in PEROXISOMES.	""	0	#FFFFFF
D012061	C01.150.252.400.794.352.500|C01.920.930.775	Relapsing Fever	An acute infection characterized by recurrent episodes of PYREXIA alternating with asymptomatic intervals of apparent recovery. This condition is caused by SPIROCHETES of the genus BORRELIA. It is transmitted by the BITES of either the body louse (PEDICULUS humanus corporis), for which humans are the reservoir, or by soft ticks of the genus ORNITHODOROS, for which rodents and other animals are the principal reservoirs.	""	0	#FFFFFF
D012075	C23.550.291.656.700	Remission, Spontaneous	A spontaneous diminution or abatement of a disease over time, without formal treatment.	""	0	#FFFFFF
D012078	C12.050.351.968.419.775|C12.200.777.419.775|C12.950.419.775|C14.907.137.727	Renal Artery Obstruction	Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).	""	0	#FFFFFF
D012080	C05.116.198.816.750|C12.050.351.968.419.795|C12.200.777.419.080|C12.950.419.795|C18.452.104.816.750|C18.452.174.845.750|C18.654.521.500.133.770.734.750|C19.642.355.480.500|C23.550.291.500.290	Chronic Kidney Disease-Mineral and Bone Disorder	Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.	""	0	#FFFFFF
D012088	C01.925.782.791	Reoviridae Infections	Infections produced by reoviruses, general or unspecified.	""	0	#FFFFFF
D012090	C26.844.150	Cumulative Trauma Disorders	Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.	""	0	#FFFFFF
D012120	C08.618	Respiration Disorders	Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.	""	0	#FFFFFF
D012127	C08.381.840.500|C08.618.840.500|C16.614.521.563	Respiratory Distress Syndrome, Newborn	A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.	""	0	#FFFFFF
D012128	C08.381.840|C08.618.840	Respiratory Distress Syndrome	A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.	""	0	#FFFFFF
D012130	C08.674|C20.543.480.680	Respiratory Hypersensitivity	A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.	""	0	#FFFFFF
D012131	C08.618.846	Respiratory Insufficiency	Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)	""	0	#FFFFFF
D012133	C08.618.846.812|C10.597.622.812|C23.888.592.636.812	Respiratory Paralysis	Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHERAL NERVE DISEASES; NEUROMUSCULAR JUNCTION DISEASES; SPINAL CORD DISEASES; injury to the PHRENIC NERVE; and other disorders.	""	0	#FFFFFF
D012135	C23.888.852.779	Respiratory Sounds	Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.	""	0	#FFFFFF
D012140	C08	Respiratory Tract Diseases	Diseases involving the RESPIRATORY SYSTEM.	""	0	#FFFFFF
D012141	C01.748|C08.730	Respiratory Tract Infections	Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.	""	0	#FFFFFF
D012142	C04.588.894.797|C08.785	Respiratory Tract Neoplasms	New abnormal growth of tissue in the RESPIRATORY SYSTEM.	""	0	#FFFFFF
D012148	C10.803|C10.886.425.800.700|C10.886.659.634	Restless Legs Syndrome	A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.	""	0	#FFFFFF
D012162	C11.270.612|C11.768.585	Retinal Degeneration	A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)	""	0	#FFFFFF
D012163	C11.768.648	Retinal Detachment	Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).	""	0	#FFFFFF
D012164	C11.768	Retinal Diseases	Diseases involving the RETINA.	""	0	#FFFFFF
D012166	C11.290.807|C11.768.710|C23.550.414.756.775	Retinal Hemorrhage	Bleeding from the vessels of the retina.	""	0	#FFFFFF
D012167	C11.768.740	Retinal Perforations	Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.	""	0	#FFFFFF
D012170	C11.768.760|C14.907.355.830.925.650|C14.907.760	Retinal Vein Occlusion	Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHEROSCLEROSIS; and other CARDIOVASCULAR DISEASES.	""	0	#FFFFFF
D012173	C11.768.773	Retinitis	Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).	""	0	#FFFFFF
D012174	C11.270.684|C11.768.585.658.500|C16.320.290.684	Retinitis Pigmentosa	Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina.	""	0	#FFFFFF
D012175	C04.557.465.625.600.725|C04.557.470.670.725|C04.557.580.625.600.725|C04.588.364.818.760|C11.270.862|C11.319.475.760|C11.768.717.760	Retinoblastoma	A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)	""	0	#FFFFFF
D012178	C11.768.836|C16.614.521.731	Retinopathy of Prematurity	A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)	""	0	#FFFFFF
D012181	C09.218.807	Retrocochlear Diseases	Pathological processes involving the VESTIBULOCOCHLEAR NERVE; BRAINSTEM; or CENTRAL NERVOUS SYSTEM. When hearing loss is due to retrocochlear pathology, it is called retrocochlear hearing loss.	""	0	#FFFFFF
D012183	C23.550.737.500	Retrograde Degeneration	Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.	""	0	#FFFFFF
D012185	C23.550.355.700	Retroperitoneal Fibrosis	A slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.	""	0	#FFFFFF
D012186	C04.588.033.731	Retroperitoneal Neoplasms	New abnormal growth of tissue in the RETROPERITONEAL SPACE.	""	0	#FFFFFF
D012188	C23.550.794|C26.748	Retropneumoperitoneum	Pathological or accidental introduction of air into the retroperitoneal space.	""	0	#FFFFFF
D012192	C01.925.782.815	Retroviridae Infections	Virus diseases caused by the RETROVIRIDAE.	""	0	#FFFFFF
D012202	C06.552.241.649|C10.228.140.163.780|C18.452.132.780	Reye Syndrome	A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.	""	0	#FFFFFF
D012206	C05.651.807	Rhabdomyolysis	Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.	""	0	#FFFFFF
D012207	C04.557.450.590.540.700	Rhabdomyoma	A benign tumor derived from striated muscle. It is extremely rare, generally occurring in the tongue, neck muscles, larynx, uvula, nasal cavity, axilla, vulva, and heart. These tumors are treated by simple excision. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1354)	""	0	#FFFFFF
D012208	C04.557.450.590.550.660|C04.557.450.795.550.660	Rhabdomyosarcoma	A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)	""	0	#FFFFFF
D012213	C01.150.252.410.890.731|C05.550.114.843|C05.799.825	Rheumatic Fever	A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.	""	0	#FFFFFF
D012214	C01.150.252.410.890.731.649|C14.280.874	Rheumatic Heart Disease	Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM.	""	0	#FFFFFF
D012215	C05.550.114.843.566|C05.799.825.566	Rheumatic Nodule	A small round or oval, mostly subcutaneous nodule made up chiefly of a mass of Aschoff bodies and seen in cases of rheumatic fever. It is differentiated from the RHEUMATOID NODULE which appears in rheumatoid arthritis, most frequently over bony prominences. (From Dorland, 27th ed)	""	0	#FFFFFF
D012216	C05.799|C17.300.775	Rheumatic Diseases	Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.	""	0	#FFFFFF
D012218	C05.550.114.154.683|C05.799.114.683|C17.300.775.099.683	Rheumatoid Nodule	Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.	""	0	#FFFFFF
D012220	C01.748.674|C08.460.799|C08.730.674|C09.603.799	Rhinitis	Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.	""	0	#FFFFFF
D012221	C08.460.799.315.500|C08.674.453.500|C09.603.799.315.500|C20.543.480.680.443.500	Rhinitis, Allergic, Perennial	Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.	""	0	#FFFFFF
D012222	C08.460.799.649|C09.603.799.649	Rhinitis, Atrophic	A chronic inflammation in which the NASAL MUCOSA gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony TURBINATES, and the foul-smelling mucus which forms a greenish crust (ozena).	""	0	#FFFFFF
D012223	C08.460.799.910|C09.603.799.910	Rhinitis, Vasomotor	A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage.	""	0	#FFFFFF
D012224	C17.800.716.500|C17.800.794.650	Rhinophyma	A manifestation of severe ROSACEA resulting in significant enlargement of the NOSE and occurring primarily in men. It is caused by hypertrophy of the SEBACEOUS GLANDS and surrounding CONNECTIVE TISSUE. The nose is reddened and marked with TELANGIECTASIS.	""	0	#FFFFFF
D012226	C01.150.252.400.310.503.500|C01.150.252.819.705|C01.748.702|C01.800.720.705|C08.460.850|C08.730.702|C09.603.850|C17.800.838.765.705	Rhinoscleroma	A granulomatous disease caused by KLEBSIELLA RHINOSCLEROMATIS infection. Despite its name, this disease is not limited to the nose and NASOPHARYNX but may affect any part of the RESPIRATORY TRACT, sometimes with extension to the lip and the skin.	""	0	#FFFFFF
D012227	C01.610.600.700	Rhinosporidiosis	Chronic, localized granulomatous infection of mucocutaneous tissues, especially the NOSE, and characterized by HYPERPLASIA and the development of POLYPS. It is found in humans and other animals and is caused by the mesomycetozoean organism RHINOSPORIDIUM SEEBERI.	""	0	#FFFFFF
D012253	C26.404.593|C26.891.733	Rib Fractures	Fractures of any of the RIBS.	""	0	#FFFFFF
D012257	C18.654.521.500.133.699.713	Riboflavin Deficiency	A dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (Dorland, 27th ed)	""	0	#FFFFFF
D012279	C05.116.198.816|C18.452.104.816|C18.452.174.845|C18.654.521.500.133.770.734	Rickets	Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.	""	0	#FFFFFF
D012282	C01.150.252.400.789.725|C01.920.914.725	Rickettsia Infections	Infections by the genus RICKETTSIA.	""	0	#FFFFFF
D012288	C01.150.252.400.789|C01.920.914	Rickettsiaceae Infections	Infections with bacteria of the family RICKETTSIACEAE.	""	0	#FFFFFF
D012295	C01.436.430.812|C01.920.500.770|C01.925.081.810|C01.925.407.810|C01.925.782.147.810|C01.925.782.417.762|C06.552.380.315.430.812|C22.467.435.812	Rift Valley Fever	An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.	""	0	#FFFFFF
D012298	C23.550.260.224.617.839	Rigor Mortis	Muscular rigidity which develops in the cadaver usually from 4 to 10 hours after death and lasts 3 or 4 days.	""	0	#FFFFFF
D012301	C01.925.782.580.600.500.700|C22.780	Rinderpest	A viral disease of cloven-hoofed animals caused by MORBILLIVIRUS. It may be acute, subacute, or chronic with the major lesions characterized by inflammation and ulceration of the entire digestive tract. The disease was declared successfully eradicated worldwide in 2010.	""	0	#FFFFFF
D012303	C23.550.210.760	Ring Chromosomes	Aberrant chromosomes with no ends, i.e., circular.	""	0	#FFFFFF
D012327	C01.925.782	RNA Virus Infections	Diseases caused by RNA VIRUSES.	""	0	#FFFFFF
D012373	C01.150.252.400.789.725.400.500|C01.920.930.887.500	Rocky Mountain Spotted Fever	An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.	""	0	#FFFFFF
D012376	C22.795	Rodent Diseases	Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).	""	0	#FFFFFF
D012391	C07.793.901.653	Root Resorption	Resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms. (Dorland, 27th ed)	""	0	#FFFFFF
D012393	C17.800.716	Rosacea	A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).	""	0	#FFFFFF
D012400	C01.925.782.791.814	Rotavirus Infections	Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.	""	0	#FFFFFF
D012409	C01.925.782.930.700.700	Rubella	An acute infectious disease caused by the RUBELLA VIRUS. The virus enters the respiratory tract via airborne droplet and spreads to the LYMPHATIC SYSTEM.	""	0	#FFFFFF
D012410	C01.925.782.930.700.700.700|C16.131.077.790	Rubella Syndrome, Congenital	Transplacental infection of the fetus with rubella usually in the first trimester of pregnancy, as a consequence of maternal infection, resulting in various developmental abnormalities in the newborn infant. They include cardiac and ocular lesions, deafness, microcephaly, mental retardation, and generalized growth retardation. (From Dorland, 27th ed)	""	0	#FFFFFF
D012415	C05.116.099.370.797|C05.660.207.850|C10.597.606.360.700|C16.131.077.804|C16.131.260.790|C16.131.621.207.850|C16.320.180.790	Rubinstein-Taybi Syndrome	A chromosomal disorder characterized by MENTAL RETARDATION, broad thumbs, webbing of fingers and toes, beaked nose, short upper lip, pouting lower lip, agenesis of corpus callosum, large foramen magnum, keloid formation, pulmonary stenosis, vertebral anomalies, chest wall anomalies, sleep apnea, and megacolon. The disease has an autosomal dominant pattern of inheritance and is associated with deletions of the short arm of chromosome 16 (16p13.3).	""	0	#FFFFFF
D012421	C26.761	Rupture	Forcible or traumatic tear or break of an organ or other soft part of the body.	""	0	#FFFFFF
D012422	C23.300.909	Rupture, Spontaneous	Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.	""	0	#FFFFFF
D012465	C07.465.815.497.325|C23.300.175.700.325	Salivary Duct Calculi	Presence of small calculi in the terminal salivary ducts (salivary sand), or stones (larger calculi) found in the larger ducts.	""	0	#FFFFFF
D012466	C07.465.815	Salivary Gland Diseases	Diseases involving the SALIVARY GLANDS.	""	0	#FFFFFF
D012467	C07.465.614.655|C07.465.815.655|C23.300.575.500.775	Salivary Gland Fistula	A fistula between a salivary duct or gland and the cutaneous surface of the oral cavity.	""	0	#FFFFFF
D012468	C04.588.443.591.824|C07.465.530.824|C07.465.815.718	Salivary Gland Neoplasms	Tumors or cancer of the SALIVARY GLANDS.	""	0	#FFFFFF
D012478	C01.150.252.400.310.821.606|C25.723.415.738	Salmonella Food Poisoning	Poisoning caused by ingestion of food harboring species of SALMONELLA. Conditions of raising, shipping, slaughtering, and marketing of domestic animals contribute to the spread of this bacterium in the food supply.	""	0	#FFFFFF
D012480	C01.150.252.400.310.821	Salmonella Infections	Infections with bacteria of the genus SALMONELLA.	""	0	#FFFFFF
D012481	C01.150.252.400.310.821.706|C22.812	Salmonella Infections, Animal	Infections in animals with bacteria of the genus SALMONELLA.	""	0	#FFFFFF
D012488	C12.050.351.500.056.390.890|C12.050.351.500.056.750.875|C12.100.250.056.390.890|C12.100.250.056.750.875	Salpingitis	Inflammation of the uterine salpinx, the trumpet-shaped FALLOPIAN TUBES, usually caused by ascending infections of organisms from the lower reproductive tract. Salpingitis can lead to tubal scarring, hydrosalpinx, tubal occlusion, INFERTILITY, and ectopic pregnancy (PREGNANCY, ECTOPIC)	""	0	#FFFFFF
D012497	C10.228.140.163.100.435.825.300.300.249|C16.320.565.189.435.825.300.300.249|C16.320.565.398.641.803.350.300.700|C16.320.565.595.554.825.300.300.800|C18.452.132.100.435.825.300.300.249|C18.452.584.563.641.803.350.300.700|C18.452.648.189.435.825.300.300.249|C18.452.648.398.641.803.350.300.700|C18.452.648.595.554.825.300.300.800	Sandhoff Disease	An autosomal recessive neurodegenerative disorder characterized by an accumulation of G(M2) GANGLIOSIDE in neurons and other tissues. It is caused by mutation in the common beta subunit of HEXOSAMINIDASE A and HEXOSAMINIDASE B. Thus this disease is also known as the O variant since both hexosaminidase A and B are missing. Clinically, it is indistinguishable from TAY-SACHS DISEASE.	""	0	#FFFFFF
D012507	C15.604.515.827	Sarcoidosis	An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.	""	0	#FFFFFF
D012509	C04.557.450.795	Sarcoma	A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.	""	0	#FFFFFF
D012510	C04.557.450.795.830.780|C04.619.857.656	Sarcoma 180	An experimental sarcoma of mice.	""	0	#FFFFFF
D012511	C04.557.450.795.830.760|C04.619.857.573	Sarcoma 37	An experimental sarcoma of mice.	""	0	#FFFFFF
D012512	C04.557.450.565.575.650.800|C04.557.450.795.620.800	Sarcoma, Ewing	A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.	""	0	#FFFFFF
D012513	C04.557.450.795.830|C04.619.857	Sarcoma, Experimental	Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.	""	0	#FFFFFF
D012514	C01.925.256.466.860|C04.557.450.795.850|C04.557.645.750	Sarcoma, Kaposi	A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.	""	0	#FFFFFF
D012515	C04.557.450.565.465.124|C20.762.750.375	Mast-Cell Sarcoma	A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.	""	0	#FFFFFF
D012516	C04.557.450.565.575.650|C04.557.450.795.620	Osteosarcoma	A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	""	0	#FFFFFF
D012517	C04.557.450.795.830.850|C04.619.857.822	Sarcoma, Yoshida	An experimental sarcoma of rats.	""	0	#FFFFFF
D012523	C01.610.752.250.634	Sarcocystosis	Infection of the striated muscle of mammals by parasites of the genus SARCOCYSTIS. Disease symptoms such as vomiting, diarrhea, muscle weakness, and paralysis are produced by sarcocystin, a toxin produced by the organism.	""	0	#FFFFFF
D012532	C01.610.858.211.480.708|C17.800.838.775.800	Scabies	A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.	""	0	#FFFFFF
D012536	C17.800.738	Scalp Dermatoses	Skin diseases involving the SCALP.	""	0	#FFFFFF
D012541	C01.150.252.410.890.823	Scarlet Fever	Infection with group A streptococci that is characterized by tonsillitis and pharyngitis. An erythematous rash is commonly present.	""	0	#FFFFFF
D012544	C05.116.821.500.500|C05.116.900.800.500.500|C05.116.900.808.500	Scheuermann Disease	A type of juvenile osteochondrosis affecting the fibrocartilaginous disc (INTERVERTEBRAL DISC) in the thoracic or thoracolumbar region of the SPINE. It is characterized by a forward concave SPINAL CURVATURE or KYPHOSIS.	""	0	#FFFFFF
D012552	C01.610.335.865.859|C01.920.922	Schistosomiasis	Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.	""	0	#FFFFFF
D012553	C01.610.335.865.859.427|C01.915.775|C01.920.922.427|C12.050.351.968.892.775|C12.200.777.892.775|C12.950.892.775	Schistosomiasis haematobia	A human disease caused by the infection of parasitic worms SCHISTOSOMA HAEMATOBIUM. It is endemic in AFRICA and parts of the MIDDLE EAST. Tissue damages most often occur in the URINARY TRACT, specifically the URINARY BLADDER.	""	0	#FFFFFF
D012554	C01.610.335.865.859.521|C01.920.922.521	Schistosomiasis japonica	Schistosomiasis caused by Schistosoma japonicum. It is endemic in the Far East and affects the bowel, liver, and spleen.	""	0	#FFFFFF
D012555	C01.610.335.865.859.576|C01.920.922.576	Schistosomiasis mansoni	Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.	""	0	#FFFFFF
D012585	C10.668.829.500.675.800|C10.668.829.600.800|C23.888.592.612.664.800	Sciatica	A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.	""	0	#FFFFFF
D012587	C08.381.844|C08.695.815|C14.240.850.968|C14.907.780|C16.131.240.850.937|C16.131.740.815	Scimitar Syndrome	An anomalous pulmonary venous return in which the right PULMONARY VEIN is not connected to the LEFT ATRIUM but to the INFERIOR VENA CAVA. Scimitar syndrome is named for the crescent- or Turkish sword-like shadow in the chest radiography and is often associated with hypoplasia of the right lung and right pulmonary artery, and dextroposition of the heart.	""	0	#FFFFFF
D012592	C17.300.550.750|C17.800.751	Scleredema Adultorum	A diffuse, non-pitting induration of the skin of unknown etiology that occurs most commonly in association with diabetes mellitus, predominantly in females. It typically begins on the face or head and spreads to other areas of the body, sometimes involving noncutaneous tissues. Often it is preceded by any of various infections, notably staphylococcal infections. The condition resolves spontaneously, usually within two years of onset. (From Dorland, 27th ed)	""	0	#FFFFFF
D012593	C16.131.831.812|C16.614.810|C17.800.804.812	Sclerema Neonatorum	A severe, sometimes fatal, disorder of adipose tissue occurring chiefly in preterm or debilitated infants suffering from an underlying illness and manifested by a diffuse, nonpitting induration of the affected tissue. The skin becomes cold, yellowish, mottled, and inflexible.	""	0	#FFFFFF
D012594	C17.300.787|C17.800.767	Scleroderma, Localized	A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.	""	0	#FFFFFF
D012595	C17.300.799|C17.800.784	Scleroderma, Systemic	A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.	""	0	#FFFFFF
D012598	C23.550.823	Sclerosis	A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.	""	0	#FFFFFF
D012600	C05.116.900.800.875	Scoliosis	An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)	""	0	#FFFFFF
D012607	C10.597.751.941.811|C11.966.811|C23.888.592.763.941.811	Scotoma	A localized defect in the visual field bordered by an area of normal vision. This occurs with a variety of EYE DISEASES (e.g., RETINAL DISEASES and GLAUCOMA); OPTIC NERVE DISEASES, and other conditions.	""	0	#FFFFFF
D012608	C01.207.800.717|C10.228.228.800.717|C10.574.843.850|C22.836.799	Scrapie	A fatal disease of the nervous system in sheep and goats, characterized by pruritus, debility, and locomotor incoordination. It is caused by proteinaceous infectious particles called PRIONS.	""	0	#FFFFFF
D012610	C01.610.858.211.503.744	Screw Worm Infection	Infection with larvae of the blow fly Cochliomyia hominivorax (Callitroga americanum), a common cause of disease in livestock in the southern and southwestern U.S.A.	""	0	#FFFFFF
D012612	C01.150.252.400.789.850|C01.920.914.850	Scrub Typhus	An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash.	""	0	#FFFFFF
D012614	C14.907.454.800|C15.378.463.515.800|C18.654.521.500.133.115.661	Scurvy	An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.	""	0	#FFFFFF
D012618	C10.228.140.163.100.435.825.775|C15.604.250.410.800|C16.320.565.189.435.825.775|C16.320.565.398.641.803.850|C16.320.565.595.554.825.775|C18.452.132.100.435.825.775|C18.452.584.563.641.803.850|C18.452.648.189.435.825.775|C18.452.648.398.641.803.850|C18.452.648.595.554.825.775	Sea-Blue Histiocyte Syndrome	A congenital disease caused by an inborn error involving APOLIPOPROTEINS E leading to abnormal LIPID METABOLISM and the accumulation of GLYCOSPHINGOLIPIDS, particularly SPHINGOMYELINS in the HISTIOCYTES. This disorder is characterized by SPLENOMEGALY and the sea-blue histiocytes in the spleen and bone marrow after May Grunwald staining.	""	0	#FFFFFF
D012625	C17.800.794	Sebaceous Gland Diseases	Diseases of the sebaceous glands such as sebaceous hyperplasia and sebaceous cell carcinoma (SEBACEOUS GLAND NEOPLASMS).	""	0	#FFFFFF
D012626	C04.588.805.578|C17.800.794.712|C17.800.882.712	Sebaceous Gland Neoplasms	New abnormal growth of tissue in the SEBACEOUS GLANDS.	""	0	#FFFFFF
D012628	C17.800.174.580|C17.800.794.230|C17.800.815.580|C17.800.859.350	Dermatitis, Seborrheic	A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.	""	0	#FFFFFF
D012640	C10.597.742|C23.888.592.742	Seizures	"Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or ""seizure disorder."""	""	0	#FFFFFF
D012652	C26.780	Self Mutilation	The act of injuring one's own body to the extent of cutting off or permanently destroying a limb or other essential part of a body.	""	0	#FFFFFF
D012678	C10.597.751|C23.888.592.763	Sensation Disorders	Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).	""	0	#FFFFFF
D012700	C23.550.470.646	Serositis	Inflammation of a serous membrane.	""	0	#FFFFFF
D012707	C04.557.475.750.847.500|C04.588.322.762.500.500|C04.588.945.440.915.500.500|C12.100.500.260.937.500.500|C12.200.294.260.937.500.500|C12.200.758.409.937.500.500|C12.900.619.937.500.500|C19.344.762.500.500|C19.391.829.782.500.500	Sertoli Cell Tumor	Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).	""	0	#FFFFFF
D012713	C17.800.174.600.800|C20.543.206.380.800|C20.543.520.770|C25.100.468.380.800	Serum Sickness	Immune complex disease caused by the administration of foreign serum or serum proteins and characterized by fever, lymphadenopathy, arthralgia, and urticaria. When they are complexed to protein carriers, some drugs can also cause serum sickness when they act as haptens inducing antibody responses.	""	0	#FFFFFF
D012719	C01.610.335.349.820|C01.610.335.508.700.750.361.852|C01.610.701.377.820|C22.674.377.820	Setariasis	Infection with nematodes of the genus Setaria. This condition is usually seen in cattle and equines and is of little pathogenic significance, although migration of the worm to the eye may lead to blindness.	""	0	#FFFFFF
D012729	C23.550.210.815	Sex Chromosome Aberrations	Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.	""	0	#FFFFFF
D012734	C12.050.351.875.253|C12.200.706.316|C12.800.316|C16.131.939.316|C19.391.119	Disorders of Sex Development	In gonochoristic organisms, congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. Effects from exposure to abnormal levels of GONADAL HORMONES in the maternal environment, or disruption of the function of those hormones by ENDOCRINE DISRUPTORS are included.	""	0	#FFFFFF
D012735	C12.100.875	Sexual Dysfunction, Physiological	Physiological disturbances in normal sexual performance in either the male or the female.	""	0	#FFFFFF
D012749	C01.221.812|C01.778|C12.100.937|C23.550.291.531.937	Sexually Transmitted Diseases	Diseases due to or propagated by sexual contact.	""	0	#FFFFFF
D012751	C04.557.386.480.750.800.775|C15.604.515.569.480.750.800.775|C15.604.515.841|C20.683.515.761.480.750.800.775|C20.683.515.920	Sezary Syndrome	A form of cutaneous T-cell lymphoma manifested by generalized exfoliative ERYTHRODERMA; PRURITUS; peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear (cerebriform) cells in the skin, LYMPH NODES, and peripheral blood (Sezary cells).	""	0	#FFFFFF
D012757	C22.836	Sheep Diseases	Diseases of domestic and mountain sheep of the genus Ovis.	""	0	#FFFFFF
D012766	C01.150.252.400.700.675|C01.748.085.600|C01.925.782.580.600.600.648|C08.730.085.600|C22.196.090.600	Pasteurellosis, Pneumonic	Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.	""	0	#FFFFFF
D012769	C23.550.835	Shock	A pathological condition manifested by failure to perfuse or oxygenate vital organs.	""	0	#FFFFFF
D012770	C14.280.647.500.750|C14.907.585.500.750|C23.550.513.355.750.750|C23.550.717.489.750.750|C23.550.835.550	Shock, Cardiogenic	Shock resulting from diminution of cardiac output in heart disease.	""	0	#FFFFFF
D012771	C23.550.414.980|C23.550.835.650	Shock, Hemorrhagic	Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.	""	0	#FFFFFF
D012772	C01.757.800|C23.550.470.790.500.800|C23.550.835.900.712	Shock, Septic	Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	""	0	#FFFFFF
D012773	C23.550.767.879|C23.550.835.775	Shock, Surgical	A type of shock that occurs as a result of a surgical procedure.	""	0	#FFFFFF
D012774	C23.550.835.888|C26.797	Shock, Traumatic	Shock produced as a result of trauma.	""	0	#FFFFFF
D012778	C06.405.469.637.832|C23.550.767.882	Short Bowel Syndrome	A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.	""	0	#FFFFFF
D012779	C05.116.099.708.857|C05.660.585.600.750|C16.131.077.850|C16.131.621.585.600.750	Short Rib-Polydactyly Syndrome	A syndrome inherited as an autosomal recessive trait and incompatible with life. The main features are narrow thorax, short ribs, scapular and pelvic dysplasia, and polydactyly.	""	0	#FFFFFF
D012783	C05.550.518.750|C26.289.750|C26.803.125	Shoulder Dislocation	Displacement of the HUMERUS from the SCAPULA.	""	0	#FFFFFF
D012784	C26.404.625|C26.803.250	Shoulder Fractures	Fractures of the proximal humerus, including the head, anatomic and surgical necks, and tuberosities.	""	0	#FFFFFF
D012790	C14.907.454.810|C14.907.940.890|C15.378.463.515.810	Shwartzman Phenomenon	Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.	""	0	#FFFFFF
D012791	C10.177.575.550.750|C10.228.140.079.612.700|C10.228.662.550.700|C14.907.514.741	Shy-Drager Syndrome	A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)	""	0	#FFFFFF
D012793	C07.465.815.793	Sialadenitis	INFLAMMATION of salivary tissue (SALIVARY GLANDS), usually due to INFECTION or injuries.	""	0	#FFFFFF
D012797	C07.465.815.802	Sialometaplasia, Necrotizing	A benign, inflammatory, variably ulcerated, occasionally bilateral, self-healing lesion of the minor salivary glands that is often confused clinically and histologically with carcinoma.	""	0	#FFFFFF
D012798	C07.465.815.815	Sialorrhea	Increased salivary flow.	""	0	#FFFFFF
D012804	C14.280.067.093.249|C14.280.067.558.536|C14.280.123.500.536|C23.550.073.093.249|C23.550.073.425.440	Sick Sinus Syndrome	A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.	""	0	#FFFFFF
D012805	C15.378.071.141.150.150.670|C15.378.420.155.668|C16.320.070.150.670|C16.320.365.155.668	Sickle Cell Trait	The condition of being heterozygous for hemoglobin S.	""	0	#FFFFFF
D012806	C08.381.483.581.750|C08.381.520.702.750|C24.800.773	Siderosis	A form of pneumoconiosis resulting from inhalation of iron in the mining dust or welding fumes.	""	0	#FFFFFF
D012810	C06.405.469.158.850	Sigmoid Diseases	Pathological processes in the SIGMOID COLON region of the large intestine (INTESTINE, LARGE).	""	0	#FFFFFF
D012811	C04.588.274.476.411.307.180.800|C06.301.371.411.307.180.800|C06.405.249.411.307.180.800|C06.405.469.158.356.180.800|C06.405.469.158.850.850|C06.405.469.491.307.180.800	Sigmoid Neoplasms	Tumors or cancer of the SIGMOID COLON.	""	0	#FFFFFF
D012816	C23.888	Signs and Symptoms	Clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient.	""	0	#FFFFFF
D012817	C23.888.821	Signs and Symptoms, Digestive	Digestive system manifestations of diseases of the gastrointestinal system or of other organs.	""	0	#FFFFFF
D012818	C23.888.852	Signs and Symptoms, Respiratory	Respiratory system manifestations of diseases of the respiratory tract or of other organs.	""	0	#FFFFFF
D012829	C08.381.483.581.760|C08.381.520.702.760|C24.800.834	Silicosis	A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.	""	0	#FFFFFF
D012830	C01.150.252.410.040.552.846.899.669|C01.748.939.669|C08.381.483.581.760.750|C08.381.520.702.760.750|C08.381.922.669|C08.730.939.669|C24.800.834.752	Silicotuberculosis	Pulmonary or extrapulmonary infection caused by MYCOBACTERIUM TUBERCULOSIS or nontuberculous mycobacteria in a patient with silicosis.	""	0	#FFFFFF
D012832	C08.381.483.125.682|C24.080.752	Silo Filler's Disease	A form of alveolitis or PNEUMONITIS caused by hypersensitivity to high level of inhaled nitrogen oxides, decomposition products of silage.	""	0	#FFFFFF
D012848	C14.280.067.558.750|C14.280.123.500.750|C23.550.073.425.780	Sinoatrial Block	Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the SINOATRIAL NODE to the HEART ATRIA. It is characterized by a delayed in heartbeat and pauses between P waves in an ELECTROCARDIOGRAM.	""	0	#FFFFFF
D012851	C10.228.140.300.525.425.500|C14.907.253.566.350.500|C14.907.355.590.213.350.500	Sinus Thrombosis, Intracranial	Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within the SKULL. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe HEADACHE; SEIZURE; and other neurological defects.	""	0	#FFFFFF
D012852	C01.748.749|C08.460.692.752|C08.730.749|C09.603.692.752	Sinusitis	Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.	""	0	#FFFFFF
D012857	C16.131.810	Situs Inversus	A congenital abnormality in which organs in the THORAX and the ABDOMEN are opposite to their normal positions (situs solitus) due to lateral transposition. Normally the STOMACH and SPLEEN are on the left, LIVER on the right, the three-lobed right lung is on the right, and the two-lobed left lung on the left. Situs inversus has a familial pattern and has been associated with a number of genes related to microtubule-associated proteins.	""	0	#FFFFFF
D012859	C05.550.114.154.774|C05.799.114.774|C07.465.815.929.669|C11.496.260.719|C17.300.775.099.774|C20.111.199.774	Sjogren's Syndrome	Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.	""	0	#FFFFFF
D012868	C16.131.831|C17.800.804	Skin Abnormalities	Congenital structural abnormalities of the skin.	""	0	#FFFFFF
D012871	C17.800	Skin Diseases	Diseases involving the DERMIS or EPIDERMIS.	""	0	#FFFFFF
D012872	C17.800.865	Skin Diseases, Vesiculobullous	Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)	""	0	#FFFFFF
D012873	C16.320.850|C17.800.827	Skin Diseases, Genetic	Diseases of the skin with a genetic component, usually the result of various inborn errors of metabolism.	""	0	#FFFFFF
D012874	C01.800|C17.800.838	Skin Diseases, Infectious	Skin diseases caused by bacteria, fungi, parasites, or viruses.	""	0	#FFFFFF
D012875	C17.800.849|C18.452.880	Skin Diseases, Metabolic	Diseases of the skin associated with underlying metabolic disorders.	""	0	#FFFFFF
D012876	C01.610.858|C17.800.838.775	Skin Diseases, Parasitic	Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.	""	0	#FFFFFF
D012877	C23.888.885	Skin Manifestations	Dermatologic disorders attendant upon non-dermatologic disease or injury.	""	0	#FFFFFF
D012878	C04.588.805|C17.800.882	Skin Neoplasms	Tumors or cancer of the SKIN.	""	0	#FFFFFF
D012883	C17.800.893	Skin Ulcer	An ULCER of the skin and underlying tissues.	""	0	#FFFFFF
D012887	C10.900.300.918|C26.404.750|C26.915.300.745	Skull Fractures	Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).	""	0	#FFFFFF
D012888	C04.588.149.721|C05.116.231.754	Skull Neoplasms	Neoplasms of the bony part of the skull.	""	0	#FFFFFF
D012891	C08.618.085.852|C10.886.425.800.750	Sleep Apnea Syndromes	Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.	""	0	#FFFFFF
D012892	C10.886.425.175|C23.888.592.796.772	Sleep Deprivation	The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.	""	0	#FFFFFF
D012893	C10.886|C23.888.592.796	Sleep Wake Disorders	Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.	""	0	#FFFFFF
D012897	C01.925.839	Slow Virus Diseases	Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES.	""	0	#FFFFFF
D012899	C01.925.256.743.826	Smallpox	An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)	""	0	#FFFFFF
D012909	C25.723.127.442|C26.176.724	Snake Bites	Bites by snakes. Bite by a venomous snake is characterized by stinging pain at the wound puncture. The venom injected at the site of the bite is capable of producing a deleterious effect on the blood or on the nervous system. (Webster's 3d ed; from Dorland, 27th ed, at snake, venomous)	""	0	#FFFFFF
D012912	C23.888.852.889	Sneezing	The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.	""	0	#FFFFFF
D012913	C23.888.852.779.850	Snoring	Rough, noisy breathing during sleep, due to vibration of the uvula and soft palate.	""	0	#FFFFFF
D012983	C04.588.839	Soft Tissue Neoplasms	Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.	""	0	#FFFFFF
D013005	C04.557.465.625.650.240.695|C04.557.470.200.025.370.695|C04.588.274.761.500.500|C04.588.322.475.500.500|C06.301.761.500.500|C06.689.667.500.500|C19.344.421.500.500	Somatostatinoma	A SOMATOSTATIN-secreting tumor derived from the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS). It is also found in the INTESTINE. Somatostatinomas are associated with DIABETES MELLITUS; CHOLELITHIASIS; STEATORRHEA; and HYPOCHLORHYDRIA. The majority of somatostatinomas have the potential for METASTASIS.	""	0	#FFFFFF
D013009	C10.886.659.635.700	Somnambulism	A parasomnia characterized by a partial arousal that occurs during stage IV of non-REM sleep. Affected individuals exhibit semipurposeful behaviors such as ambulation and are difficult to fully awaken. Children are primarily affected, with a peak age range of 4-6 years.	""	0	#FFFFFF
D013031	C01.610.335.190.304.780	Sparganosis	Infection of animals, including fish and man, with a developmental stage of Diphyllobothrium. This stage has recently been referred to as a plerocercoid but the name sparganum has persisted. Therefore, infection of fish or other animals with the plerocercoid larvae is sparganosis. Fish-eating mammals, including man, are the final hosts.	""	0	#FFFFFF
D013035	C10.597.613.750|C23.888.592.608.750	Spasm	An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.	""	0	#FFFFFF
D013036	C10.228.140.490.375.760|C10.228.140.490.493.875	Spasms, Infantile	An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)	""	0	#FFFFFF
D013064	C10.597.606.150.500.800|C23.888.592.604.150.500.800	Speech Disorders	Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.	""	0	#FFFFFF
D013086	C12.100.500.693|C12.200.294.693	Spermatic Cord Torsion	The twisting of the SPERMATIC CORD due to an anatomical abnormality that left the TESTIS mobile and dangling in the SCROTUM. The initial effect of testicular torsion is obstruction of venous return. Depending on the duration and degree of cord rotation, testicular symptoms range from EDEMA to interrupted arterial flow and testicular pain. If blood flow to testis is absent for 4 to 6 h, SPERMATOGENESIS may be permanently lost.	""	0	#FFFFFF
D013088	C12.100.500.731|C12.200.294.731|C23.300.306.750	Spermatocele	A cystic dilation of the EPIDIDYMIS, usually in the head portion (caput epididymis). The cyst fluid contains dead SPERMATOZOA and can be easily differentiated from TESTICULAR HYDROCELE and other testicular lesions.	""	0	#FFFFFF
D013103	C15.378.071.141.150.785|C16.320.070.785	Spherocytosis, Hereditary	A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.	""	0	#FFFFFF
D013106	C10.228.140.163.100.435.825|C16.320.565.189.435.825|C16.320.565.398.641.803|C16.320.565.595.554.825|C18.452.132.100.435.825|C18.452.584.563.641.803|C18.452.648.189.435.825|C18.452.648.398.641.803|C18.452.648.595.554.825	Sphingolipidoses	A group of inherited metabolic disorders characterized by the intralysosomal accumulation of SPHINGOLIPIDS primarily in the CENTRAL NERVOUS SYSTEM and to a variable degree in the visceral organs. They are classified by the enzyme defect in the degradation pathway and the substrate accumulation (or storage). Clinical features vary in subtypes but neurodegeneration is a common sign.	""	0	#FFFFFF
D013117	C10.228.854.761|C26.819.678	Spinal Cord Compression	Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.	""	0	#FFFFFF
D013118	C10.228.854	Spinal Cord Diseases	Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.	""	0	#FFFFFF
D013119	C10.228.854.763|C10.900.850|C26.819	Spinal Cord Injuries	Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).	""	0	#FFFFFF
D013120	C04.588.614.250.803|C10.228.854.765|C10.551.240.750	Spinal Cord Neoplasms	Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.	""	0	#FFFFFF
D013121	C05.116.900.800	Spinal Curvatures	Deformities of the SPINE characterized by abnormal bending or flexure in the vertebral column. They may be bending forward (KYPHOSIS), backward (LORDOSIS), or sideway (SCOLIOSIS).	""	0	#FFFFFF
D013122	C05.116.900	Spinal Diseases	Diseases involving the SPINE.	""	0	#FFFFFF
D013124	C26.117.500	Spinal Injuries	Injuries involving the vertebral column.	""	0	#FFFFFF
D013125	C04.588.149.828|C05.116.231.828|C05.116.900.801	Spinal Neoplasms	New abnormal growth of tissue in the SPINE.	""	0	#FFFFFF
D013128	C05.116.900.815	Spinal Osteophytosis	Outgrowth of immature bony processes or bone spurs (OSTEOPHYTE) from the VERTEBRAE, reflecting the presence of degenerative disease and calcification. It commonly occurs in cervical and lumbar SPONDYLOSIS.	""	0	#FFFFFF
D013130	C05.116.900.825	Spinal Stenosis	Narrowing of the spinal canal.	""	0	#FFFFFF
D013132	C10.228.140.252.700|C10.228.854.787|C10.574.500.825|C16.320.400.780	Spinocerebellar Degenerations	A heterogenous group of degenerative syndromes marked by progressive cerebellar dysfunction either in isolation or combined with other neurologic manifestations. Sporadic and inherited subtypes occur. Inheritance patterns include autosomal dominant, autosomal recessive, and X-linked.	""	0	#FFFFFF
D013145	C01.150.252.400.794	Spirochaetales Infections	Infections with bacteria of the order SPIROCHAETALES.	""	0	#FFFFFF
D013158	C15.604.744	Splenic Diseases	Diseases involving the SPLEEN.	""	0	#FFFFFF
D013159	C14.907.795|C15.604.744.617|C23.550.513.355.937|C23.550.717.489.937	Splenic Infarction	Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)	""	0	#FFFFFF
D013160	C04.588.842|C15.604.744.680	Splenic Neoplasms	Tumors or cancer of the SPLEEN.	""	0	#FFFFFF
D013161	C15.604.744.742|C26.017.680|C26.761.555	Splenic Rupture	Rupture of the SPLEEN due to trauma or disease.	""	0	#FFFFFF
D013163	C23.300.775.750	Splenomegaly	Enlargement of the spleen.	""	0	#FFFFFF
D013166	C01.160.762|C05.116.165.762|C05.116.900.853	Spondylitis	Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.	""	0	#FFFFFF
D013167	C05.116.900.853.625.800.744.500|C05.550.069.340.500|C05.550.114.865.800.744.500	Spondylitis, Ankylosing	A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.	""	0	#FFFFFF
D013168	C05.116.900.938.500.500	Spondylolisthesis	Forward displacement of a superior vertebral body over the vertebral body below.	""	0	#FFFFFF
D013169	C05.116.900.938.500	Spondylolysis	Deficient development or degeneration of a portion of the VERTEBRA, usually in the pars interarticularis (the bone bridge between the superior and inferior facet joints of the LUMBAR VERTEBRAE) leading to SPONDYLOLISTHESIS.	""	0	#FFFFFF
D013174	C01.150.703.302.675|C01.800.200.675|C17.800.838.208.675	Sporotrichosis	The commonest and least serious of the deep mycoses, characterized by nodular lesions of the cutaneous and subcutaneous tissues. It is caused by inhalation of contaminated dust or by infection of a wound with SPOROTHRIX.	""	0	#FFFFFF
D013180	C26.844	Sprains and Strains	A collective term for muscle and ligament injuries without dislocation or fracture. A sprain is a joint injury in which some of the fibers of a supporting ligament are ruptured but the continuity of the ligament remains intact. A strain is an overstretching or overexertion of some part of the musculature.	""	0	#FFFFFF
D013182	C06.405.469.637.850|C18.452.603.850	Sprue, Tropical	A chronic malabsorption syndrome, occurring mainly in residents of or visitors to the tropics or subtropics. The failed INTESTINAL ABSORPTION of nutrients from the SMALL INTESTINE results in MALNUTRITION and ANEMIA that is due to FOLIC ACID deficiency.	""	0	#FFFFFF
D013202	C01.150.252.410.868.806|C25.723.415.846	Staphylococcal Food Poisoning	Poisoning by staphylococcal toxins present in contaminated food.	""	0	#FFFFFF
D013203	C01.150.252.410.868	Staphylococcal Infections	Infections with bacteria of the genus STAPHYLOCOCCUS.	""	0	#FFFFFF
D013206	C01.150.252.410.868.951.770|C01.150.252.819.770.770|C01.800.720.770.770|C17.800.838.765.770.770	Staphylococcal Scalded Skin Syndrome	A disease of infants due to group 2 phage type 17 staphylococci that produce an epidermolytic exotoxin. Superficial fine vesicles and bullae form and rupture easily, resulting in loss of large sheets of epidermis.	""	0	#FFFFFF
D013207	C01.150.252.410.868.951|C01.150.252.819.770|C01.800.720.770|C17.800.838.765.770	Staphylococcal Skin Infections	Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.	""	0	#FFFFFF
D013217	C18.654.521.750	Starvation	Lengthy and continuous deprivation of food. (Stedman, 25th ed)	""	0	#FFFFFF
D013224	C08.127.108.880|C08.674.095.880|C20.543.480.680.095.880	Status Asthmaticus	A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.	""	0	#FFFFFF
D013226	C10.597.742.785|C23.888.592.742.785	Status Epilepticus	A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)	""	0	#FFFFFF
D013231	C18.654.521.500.133.841.682|C22.880	Steatitis	"A disease of cats and mink characterized by a marked inflammation of adipose tissue and the deposition of ""ceroid"" pigment in the interstices of the adipose cells. It is believed to be caused by feeding diets containing too much unsaturated fatty acid and too little vitamin E. (Merck Veterinary Manual, 5th ed; Stedman, 25th ed)"	""	0	#FFFFFF
D013262	C07.465.864.500|C17.800.174.600.900|C17.800.229.400.683|C17.800.865.475.683|C20.543.206.380.900|C25.100.468.380.900	Stevens-Johnson Syndrome	Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.	""	0	#FFFFFF
D013271	C06.405.748.300	Gastric Dilatation	Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.	""	0	#FFFFFF
D013272	C06.405.748	Stomach Diseases	Pathological processes involving the STOMACH.	""	0	#FFFFFF
D013273	C06.405.205.282.750.687|C23.300.415.687	Diverticulum, Stomach	Saccular, outward protrusion of all or a portion of the wall of the STOMACH.	""	0	#FFFFFF
D013274	C04.588.274.476.767|C06.301.371.767|C06.405.249.767|C06.405.748.789	Stomach Neoplasms	Tumors or cancer of the STOMACH.	""	0	#FFFFFF
D013275	C06.405.748.824|C26.017.809|C26.761.684	Stomach Rupture	Bursting of the STOMACH.	""	0	#FFFFFF
D013276	C06.405.469.275.800.849|C06.405.748.586.849	Stomach Ulcer	Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	""	0	#FFFFFF
D013277	C06.405.748.895	Stomach Volvulus	Twisting of the STOMACH that may result in gastric ISCHEMIA and GASTRIC OUTLET OBSTRUCTION. It is often associated with DIAPHRAGMATIC HERNIA.	""	0	#FFFFFF
D013280	C07.465.864	Stomatitis	INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.	""	0	#FFFFFF
D013281	C07.465.864.750	Stomatitis, Aphthous	A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)	""	0	#FFFFFF
D013282	C07.465.864.875	Stomatitis, Denture	Inflammation of the mouth due to denture irritation.	""	0	#FFFFFF
D013283	C01.925.256.466.382.834|C07.465.864.937	Stomatitis, Herpetic	Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.	""	0	#FFFFFF
D013285	C10.292.562.887|C11.590.810	Strabismus	Misalignment of the visual axes of the eyes. In comitant strabismus the degree of ocular misalignment does not vary with the direction of gaze. In noncomitant strabismus the degree of misalignment varies depending on direction of gaze or which eye is fixating on the target. (Miller, Walsh & Hoyt's Clinical Neuro-Ophthalmology, 4th ed, p641)	""	0	#FFFFFF
D013290	C01.150.252.410.890	Streptococcal Infections	Infections with bacteria of the genus STREPTOCOCCUS.	""	0	#FFFFFF
D013319	C01.610.335.349.840|C01.610.335.508.700.775.773|C01.610.701.377.840|C22.488.861|C22.674.377.840	Strongyle Infections, Equine	Infection of horses with parasitic nematodes of the superfamily STRONGYLOIDEA. Characteristics include the development of hemorrhagic nodules on the abdominal peritoneum.	""	0	#FFFFFF
D013322	C01.610.335.508.700.700.799	Strongyloidiasis	Infection with nematodes of the genus STRONGYLOIDES. The presence of larvae may produce pneumonitis and the presence of adult worms in the intestine could lead to moderate to severe diarrhea.	""	0	#FFFFFF
D013330	C04.557.465.910.850	Struma Ovarii	A rare teratoid tumor of the ovary composed almost entirely of thyroid tissue, with large follicles containing abundant colloid. Occasionally there are symptoms of hyperthyroidism. 5-10% of struma ovarii become malignant, the only absolute criterion for which is the presence of metastasis. (Dorland, 27th ed; Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D013341	C04.557.645.375.850|C10.562.800|C14.907.077.850	Sturge-Weber Syndrome	A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.	""	0	#FFFFFF
D013342	C10.597.606.150.500.800.750|C23.888.592.604.150.500.800.750	Stuttering	A disturbance in the normal fluency and time patterning of speech that is inappropriate for the individual's age. This disturbance is characterized by frequent repetitions or prolongations of sounds or syllables. Various other types of speech dysfluencies may also be involved including interjections, broken words, audible or silent blocking, circumlocutions, words produced with an excess of physical tension, and monosyllabic whole word repetitions. Stuttering may occur as a developmental condition in childhood or as an acquired disorder which may be associated with BRAIN INFARCTIONS and other BRAIN DISEASES. (From DSM-IV, 1994)	""	0	#FFFFFF
D013344	C01.207.245.340.600|C01.207.399.750.600|C01.925.182.525.600|C01.925.782.580.600.500.500.800|C01.925.839.862|C10.228.140.430.520.750.600|C10.228.228.245.340.600|C10.228.228.399.750.600|C10.586.250.520.750.600	Subacute Sclerosing Panencephalitis	A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)	""	0	#FFFFFF
D013345	C10.228.140.300.535.800|C14.907.253.573.800|C23.550.414.913.850	Subarachnoid Hemorrhage	Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.	""	0	#FFFFFF
D013349	C10.228.140.300.150.956.700|C14.907.253.092.956.700	Subclavian Steal Syndrome	A clinically significant reduction in blood supply to the BRAIN STEM and CEREBELLUM (i.e., VERTEBROBASILAR INSUFFICIENCY) resulting from reversal of blood flow through the VERTEBRAL ARTERY from occlusion or stenosis of the proximal subclavian or brachiocephalic artery. Common symptoms include VERTIGO; SYNCOPE; and INTERMITTENT CLAUDICATION of the involved upper extremity. Subclavian steal may also occur in asymptomatic individuals. (From J Cardiovasc Surg 1994;35(1):11-4; Acta Neurol Scand 1994;90(3):174-8)	""	0	#FFFFFF
D013352	C23.550.325.500	Subcutaneous Emphysema	Presence of air or gas in the subcutaneous tissues of the body.	""	0	#FFFFFF
D013353	C01.207.709.675|C10.228.140.870|C10.228.228.709.675	Subdural Effusion	Leakage and accumulation of CEREBROSPINAL FLUID in the subdural space which may be associated with an infectious process; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; INTRACRANIAL HYPOTENSION; and other conditions.	""	0	#FFFFFF
D013354	C01.207.709.300|C01.830.305.330|C10.228.228.709.300|C23.550.470.756.305.500	Empyema, Subdural	An intracranial or rarely intraspinal suppurative process invading the space between the inner surface of the DURA MATER and the outer surface of the ARACHNOID.	""	0	#FFFFFF
D013362	C04.588.443.591.824.882|C07.465.530.824.882|C07.465.815.718.870	Sublingual Gland Neoplasms	Neoplasms of the sublingual glands.	""	0	#FFFFFF
D013364	C07.465.815.882	Submandibular Gland Diseases	Diseases involving the SUBMANDIBULAR GLAND.	""	0	#FFFFFF
D013365	C04.588.443.591.824.885|C07.465.530.824.885|C07.465.815.718.885|C07.465.815.882.500	Submandibular Gland Neoplasms	New abnormal growth of tissue in the SUBMANDIBULAR GLAND.	""	0	#FFFFFF
D013369	C01.463.600.500|C01.830.025.020.810|C06.844.640.500	Subphrenic Abscess	Accumulation of purulent EXUDATES beneath the DIAPHRAGM, also known as upper abdominal abscess. It is usually associated with PERITONITIS or postoperative infections.	""	0	#FFFFFF
D013375	C25.775.835	Substance Withdrawal Syndrome	Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.	""	0	#FFFFFF
D013398	C23.550.260.322.625|C23.550.260.657.500	Sudden Infant Death	The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)	""	0	#FFFFFF
D013436	C15.378.896	Sulfhemoglobinemia	A morbid condition due to the presence of sulfmethemoglobin in the blood. It is marked by persistent cyanosis, but the blood count does not reveal any special abnormality in the blood. It is thought to be caused by the action of hydrogen sulfide absorbed from the intestine. (Stedman, 25th ed)	""	0	#FFFFFF
D013471	C17.800.600.725|C26.200.855	Sunburn	An injury to the skin causing erythema, tenderness, and sometimes blistering and resulting from excessive exposure to the sun. The reaction is produced by the ultraviolet radiation in sunlight.	""	0	#FFFFFF
D013474	C26.522.500.500	Sunstroke	Heat stroke caused by exposure to the sun. It is characterized by dangerously high BODY TEMPERATURE; red, hot skin; DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.	""	0	#FFFFFF
D013478	C06.405.469.275.395.890	Superior Mesenteric Artery Syndrome	DUODENAL OBSTRUCTION by the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) which travels in the root of the MESENTERY and crosses over the DUODENUM. The syndrome is characterized by the dilated proximal duodenum and STOMACH, bloating, ABDOMINAL CRAMPS, and VOMITING. Often it is observed in patient with body casts after spinal surgery.	""	0	#FFFFFF
D013479	C14.907.800	Superior Vena Cava Syndrome	A condition that occurs when the obstruction of the thin-walled SUPERIOR VENA CAVA interrupts blood flow from the head, upper extremities, and thorax to the RIGHT ATRIUM. Obstruction can be caused by NEOPLASMS; THROMBOSIS; ANEURYSM; or external compression. The syndrome is characterized by swelling and/or CYANOSIS of the face, neck, and upper arms.	""	0	#FFFFFF
D013492	C01.830|C23.550.470.756	Suppuration	A pathologic process consisting in the formation of pus.	""	0	#FFFFFF
D013494	C10.228.140.079.882|C10.228.662.700|C10.292.562.750.500|C10.574.945.500|C10.597.622.447.690|C11.590.472.500|C23.888.592.636.447.690	Supranuclear Palsy, Progressive	A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)	""	0	#FFFFFF
D013529	C23.550.767.887	Surgical Wound Dehiscence	Pathologic process consisting of a partial or complete disruption of the layers of a surgical wound.	""	0	#FFFFFF
D013530	C01.947.692|C23.550.767.925	Surgical Wound Infection	Infection occurring at the site of a surgical incision.	""	0	#FFFFFF
D013540	C18.654.521.500.857|C22.836.886	Swayback	Congenital locomotor ataxia of lambs, thought to be associated with copper deficiency. It is characterized clinically by progressive incoordination of the hind limbs and pathologically by disruption of neuron and myelin development in the central nervous system. It is caused by a deficiency of metabolizable copper in the ewe during the last half of her pregnancy. (Dorland, 28th ed; Stedman, 26th ed)	""	0	#FFFFFF
D013543	C17.800.946	Sweat Gland Diseases	Diseases of the SWEAT GLANDS.	""	0	#FFFFFF
D013544	C04.588.805.776|C17.800.882.743|C17.800.946.743	Sweat Gland Neoplasms	New abnormal growth of tissue in the SWEAT GLANDS.	""	0	#FFFFFF
D013547	C10.177.825|C17.800.946.350.843	Sweating, Gustatory	An autonomic disorder characterized by excessive sweating of the forehead, upper lip, perioral region, or sternum subsequent to gustatory stimuli. The auriculotemporal syndrome features facial flushing or sweating limited to the distribution of the auriculotemporal nerve and may develop after trauma to the parotid gland, in association with PAROTID NEOPLASMS, or following their surgical removal. (From Ann Neurol 1997 Dec;42(6):973-5)	""	0	#FFFFFF
D013553	C22.905	Swine Diseases	Diseases of domestic swine and of the wild boar of the genus Sus.	""	0	#FFFFFF
D013554	C01.150.252.410.334.776|C22.331.693|C22.905.832	Swine Erysipelas	An acute and chronic contagious disease of young pigs caused by Erysipelothrix insidiosa.	""	0	#FFFFFF
D013555	C01.925.782.687.359.855|C22.905.850	Swine Vesicular Disease	An enterovirus infection of swine clinically indistinguishable from FOOT-AND-MOUTH DISEASE, vesicular stomatitis, and VESICULAR EXANTHEMA OF SWINE. It is caused by a strain of HUMAN ENTEROVIRUS B.	""	0	#FFFFFF
D013568	C23	Pathological Conditions, Signs and Symptoms	Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome.	""	0	#FFFFFF
D013575	C10.597.606.358.800.600|C23.888.592.604.359.800.600	Syncope	A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)	""	0	#FFFFFF
D013576	C05.116.099.370.894.819|C05.660.585.800|C05.660.906.819|C16.131.621.585.800|C16.131.621.906.819	Syndactyly	A congenital anomaly of the hand or foot, marked by the webbing between adjacent fingers or toes. Syndactylies are classified as complete or incomplete by the degree of joining. Syndactylies can also be simple or complex. Simple syndactyly indicates joining of only skin or soft tissue; complex syndactyly marks joining of bony elements.	""	0	#FFFFFF
D013577	C23.550.288.500	Syndrome	A characteristic symptom complex.	""	0	#FFFFFF
D013580	C05.116.099.370.894|C05.660.906|C16.131.621.906	Synostosis	A union between adjacent bones or parts of a single bone formed by osseous material, such as ossified connecting cartilage or fibrous tissue. (Dorland, 27th ed)	""	0	#FFFFFF
D013581	C04.182.867	Synovial Cyst	Non-neoplastic tumor-like lesions at joints, developed from the SYNOVIAL MEMBRANE of a joint through the JOINT CAPSULE into the periarticular tissues. They are filled with SYNOVIAL FLUID with a smooth and translucent appearance. A synovial cyst can develop from any joint, but most commonly at the back of the knee, where it is known as POPLITEAL CYST.	""	0	#FFFFFF
D013584	C04.557.450.565.835|C04.557.450.795.875	Sarcoma, Synovial	A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)	""	0	#FFFFFF
D013585	C05.550.870	Synovitis	Inflammation of the SYNOVIAL MEMBRANE.	""	0	#FFFFFF
D013586	C04.557.450.565.380.690.500|C05.550.870.445.500|C05.651.869.762.500	Synovitis, Pigmented Villonodular	Diffuse outgrowth arising from the SYNOVIAL MEMBRANE; SYNOVIAL BURSA; or TENDON sheath around the joint cavity, with extension to surrounding soft tissue. It is characterized by pigmented HEMOSIDERIN-containing MACROPHAGES; FOAM CELLS; and multinucleated GIANT CELLS. It usually occurs in the hands and feet, and around large joints, such as in the ankle and knee joints.	""	0	#FFFFFF
D013587	C01.150.252.400.794.840.500|C01.150.252.400.840.500|C01.150.252.734.859|C01.221.812.281.859|C01.778.281.859|C12.100.937.281.859	Syphilis	A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.	""	0	#FFFFFF
D013589	C01.150.252.400.794.840.500.875|C01.150.252.400.840.500.875|C01.190.500|C14.260.500	Syphilis, Cardiovascular	Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.	""	0	#FFFFFF
D013590	C01.150.252.400.794.840.500.937|C01.150.252.400.840.500.937|C16.614.868	Syphilis, Congenital	Syphilis acquired in utero and manifested by any of several characteristic tooth (Hutchinson's teeth) or bone malformations and by active mucocutaneous syphilis at birth or shortly thereafter. Ocular and neurologic changes may also occur.	""	0	#FFFFFF
D013591	C01.150.252.400.794.840.500.968|C01.150.252.400.840.500.968|C01.150.252.819.790|C01.800.720.790|C17.800.838.765.790	Syphilis, Cutaneous	Cutaneous lesions arising from infection with Treponema pallidum. In the primary stage, 18-21 days following infection, one or more chancres appear. If untreated, the subsequent stages of the disease appear as syphilids. These eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p409)	""	0	#FFFFFF
D013592	C01.150.252.400.794.840.500.984|C01.150.252.400.840.500.984|C01.550.750	Syphilis, Latent	The stage of syphilis that occurs following the primary (CHANCRE) and secondary stages. The patient is asymptomatic at the latent stage but remains seropositive for the SPIROCHETE.	""	0	#FFFFFF
D013595	C10.228.854.833	Syringomyelia	Longitudinal cavities in the spinal cord, most often in the cervical region, which may extend for multiple spinal levels. The cavities are lined by dense, gliogenous tissue and may be associated with SPINAL CORD NEOPLASMS; spinal cord traumatic injuries; and vascular malformations. Syringomyelia is marked clinically by pain and PARESTHESIA, muscular atrophy of the hands, and analgesia with thermoanesthesia of the hands and arms, but with the tactile sense preserved (sensory dissociation). Lower extremity spasticity and incontinence may also develop. (From Adams et al., Principles of Neurology, 6th ed, p1269)	""	0	#FFFFFF
D013606	C01.150.252.223.600.800|C01.150.252.400.794.840.500.750.800|C01.150.252.400.840.500.750.800|C01.207.180.600.800|C10.228.228.180.600.800|C10.228.854.889	Tabes Dorsalis	Parenchymatous NEUROSYPHILIS marked by slowly progressive degeneration of the posterior columns, posterior roots, and ganglia of the spinal cord. The condition tends to present 15 to 20 years after the initial infection and is characterized by lightening-like pains in the lower extremities, URINARY INCONTINENCE; ATAXIA; severely impaired position and vibratory sense, abnormal gait (see GAIT DISORDERS, NEUROLOGIC), OPTIC ATROPHY; Argyll-Robertson pupils, hypotonia, hyperreflexia, and trophic joint degeneration (Charcot's Joint; see ARTHROPATHY, NEUROGENIC). (From Adams et al., Principles of Neurology, 6th ed, p726)	""	0	#FFFFFF
D013610	C14.280.067.845|C14.280.123.875|C23.550.073.845	Tachycardia	Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.	""	0	#FFFFFF
D013611	C14.280.067.845.787.249|C14.280.123.875.787.249|C23.550.073.845.787.500	Tachycardia, Atrioventricular Nodal Reentry	Abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE. The common type involves a blocked atrial impulse in the slow pathway which reenters the fast pathway in a retrograde direction and simultaneously conducts to the atria and the ventricles leading to rapid HEART RATE of 150-250 beats per minute.	""	0	#FFFFFF
D013612	C14.280.067.845.880.315|C14.280.123.875.880.315|C23.550.073.845.880.315	Tachycardia, Ectopic Atrial	Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.	""	0	#FFFFFF
D013613	C14.280.067.845.880.320|C14.280.123.875.880.320|C23.550.073.845.880.320	Tachycardia, Ectopic Junctional	A rare form of supraventricular tachycardia caused by automatic, not reentrant, conduction initiated from sites at the atrioventricular junction, but not the ATRIOVENTRICULAR NODE. It usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication with a HEART RATE ranging from 140 to 250 beats per minute.	""	0	#FFFFFF
D013614	C14.280.067.845.695|C14.280.123.875.695|C23.550.073.845.695	Tachycardia, Paroxysmal	Abnormally rapid heartbeats with sudden onset and cessation.	""	0	#FFFFFF
D013615	C14.280.067.845.787.500|C14.280.123.875.787.500|C23.550.073.845.787.750	Tachycardia, Sinoatrial Nodal Reentry	Abnormally rapid heartbeats caused by reentry circuit in or around the SINOATRIAL NODE. It is characterized by sudden onset and offset episodes of tachycardia with a HEART RATE of 100-150 beats per minute. The P wave is identical to the sinus P wave but with a longer PR interval.	""	0	#FFFFFF
D013616	C14.280.067.845.880.845|C14.280.123.875.880.845|C23.550.073.845.880.845	Tachycardia, Sinus	Simple rapid heartbeats caused by rapid discharge of impulses from the SINOATRIAL NODE, usually between 100 and 180 beats/min in adults. It is characterized by a gradual onset and termination. Sinus tachycardia is common in infants, young children, and adults during strenuous physical activities.	""	0	#FFFFFF
D013617	C14.280.067.845.880|C14.280.123.875.880|C23.550.073.845.880	Tachycardia, Supraventricular	A generic expression for any tachycardia that originates above the BUNDLE OF HIS.	""	0	#FFFFFF
D013622	C01.610.335.190.902	Taeniasis	Infection with tapeworms of the genus Taenia.	""	0	#FFFFFF
D013625	C14.907.109.239.650|C14.907.940.090.800|C17.800.862.875	Takayasu Arteritis	A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.	""	0	#FFFFFF
D013631	C10.668.829.800.875|C16.320.565.398.500.330.750|C18.452.584.500.875.330.750|C18.452.584.563.500.330.750|C18.452.648.398.500.330.750	Tangier Disease	An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.	""	0	#FFFFFF
D013641	C10.668.829.500.700.800|C10.668.829.550.800	Tarsal Tunnel Syndrome	Entrapment of the distal branches of the posterior TIBIAL NERVE (which divides into the medial plantar, lateral plantar, and calcanial nerves) in the tarsal tunnel, which lies posterior to the internal malleolus and beneath the retinaculum of the flexor muscles of the foot. Symptoms include ankle pain radiating into the foot which tends to be aggravated by walking. Examination may reveal Tinel's sign (radiating pain following nerve percussion) over the tibial nerve at the ankle, weakness and atrophy of the small foot muscles, or loss of sensation in the foot. (From Foot Ankle 1990;11(1):47-52)	""	0	#FFFFFF
D013651	C10.597.751.861|C23.888.592.763.861	Taste Disorders	Conditions characterized by an alteration in gustatory function or perception. Taste disorders are frequently associated with OLFACTION DISORDERS. Additional potential etiologies include METABOLIC DISEASES; DRUG TOXICITY; and taste pathway disorders (e.g., TASTE BUD diseases; FACIAL NERVE DISEASES; GLOSSOPHARYNGEAL NERVE DISEASES; and BRAIN STEM diseases).	""	0	#FFFFFF
D013661	C10.228.140.163.100.435.825.300.300.500|C16.320.565.189.435.825.300.300.500|C16.320.565.398.641.803.350.300.850|C16.320.565.595.554.825.300.300.840|C18.452.132.100.435.825.300.300.500|C18.452.584.563.641.803.350.300.850|C18.452.648.189.435.825.300.300.500|C18.452.648.398.641.803.350.300.850|C18.452.648.595.554.825.300.300.840	Tay-Sachs Disease	An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry.	""	0	#FFFFFF
D013683	C14.907.454.900|C14.907.823.780|C15.378.463.515.900|C16.131.240.850.968	Telangiectasia, Hereditary Hemorrhagic	An autosomal dominant vascular anomaly characterized by telangiectases of the skin and mucous membranes and by recurrent gastrointestinal bleeding. This disorder is caused by mutations of a gene (on chromosome 9q3) which encodes endoglin, a membrane glycoprotein that binds TRANSFORMING GROWTH FACTOR BETA.	""	0	#FFFFFF
D013684	C14.907.823	Telangiectasis	Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.	""	0	#FFFFFF
D013700	C10.114.875.700|C10.228.140.300.850.500|C14.907.253.946.700|C14.907.940.090.530|C14.907.940.907.700|C17.800.862.252|C20.111.258.962.800	Giant Cell Arteritis	A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)	""	0	#FFFFFF
D013705	C05.500.607.221.897|C05.550.905|C05.651.243.897|C07.320.610.291.897|C07.678	Temporomandibular Joint Disorders	A variety of conditions affecting the anatomic and functional characteristics of the temporomandibular joint. Factors contributing to the complexity of temporomandibular diseases are its relation to dentition and mastication and the symptomatic effects in other areas which account for referred pain to the joint and the difficulties in applying traditional diagnostic procedures to temporomandibular joint pathology where tissue is rarely obtained and x-rays are often inadequate or nonspecific. Common diseases are developmental abnormalities, trauma, subluxation, luxation, arthritis, and neoplasia. (From Thoma's Oral Pathology, 6th ed, pp577-600)	""	0	#FFFFFF
D013706	C05.500.607.221.897.897|C05.550.905.905|C05.651.243.897.897|C05.651.550.905|C07.320.610.291.897.897|C07.678.949	Temporomandibular Joint Dysfunction Syndrome	A symptom complex consisting of pain, muscle tenderness, clicking in the joint, and limitation or alteration of mandibular movement. The symptoms are subjective and manifested primarily in the masticatory muscles rather than the temporomandibular joint itself. Etiologic factors are uncertain but include occlusal dysharmony and psychophysiologic factors.	""	0	#FFFFFF
D013708	C26.874	Tendon Injuries	Injuries to the fibrous cords of connective tissue which attach muscles to bones or other structures.	""	0	#FFFFFF
D013716	C05.651.869.435.500|C26.088.890|C26.874.800.500.500	Tennis Elbow	A condition characterized by pain in or near the lateral humeral epicondyle or in the forearm extensor muscle mass as a result of unusual strain. It occurs due repetitive stresses on the elbow from activities such as tennis playing.	""	0	#FFFFFF
D013717	C05.651.869.870	Tenosynovitis	Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.	""	0	#FFFFFF
D013724	C04.557.465.910	Teratoma	A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)	""	0	#FFFFFF
D013733	C12.100.500.829|C12.200.294.829|C19.391.829	Testicular Diseases	Pathological processes of the TESTIS.	""	0	#FFFFFF
D013734	C12.050.351.875.253.096.500|C12.200.706.316.096.500|C12.800.316.096.500|C16.131.939.316.096.500|C16.320.322.061|C19.391.119.096.500	Androgen-Insensitivity Syndrome	A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.	""	0	#FFFFFF
D013736	C04.588.322.762|C04.588.945.440.915|C12.100.500.260.937|C12.200.294.260.937|C12.200.758.409.937|C12.900.619.937|C19.344.762|C19.391.829.782	Testicular Neoplasms	Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.	""	0	#FFFFFF
D013742	C01.150.252.410.222.864	Tetanus	A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.	""	0	#FFFFFF
D013746	C10.597.613.875|C18.452.174.509.700|C23.888.592.608.875	Tetany	A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This condition is associated with unstable depolarization of axonal membranes, primarily in the peripheral nervous system. Tetany usually results from HYPOCALCEMIA or reduced serum levels of MAGNESIUM that may be associated with HYPERVENTILATION; HYPOPARATHYROIDISM; RICKETS; UREMIA; or other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1490)	""	0	#FFFFFF
D013771	C14.240.400.849|C14.280.400.849|C16.131.240.400.849	Tetralogy of Fallot	A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.	""	0	#FFFFFF
D013786	C10.228.140.915	Thalamic Diseases	Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestations include sensory loss, MOVEMENT DISORDERS; ATAXIA, pain syndromes, visual disorders, a variety of neuropsychological conditions, and COMA. Relatively common etiologies include CEREBROVASCULAR DISORDERS; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; BRAIN HYPOXIA; INTRACRANIAL HEMORRHAGES; and infectious processes.	""	0	#FFFFFF
D013789	C15.378.071.141.150.875|C15.378.420.826|C16.320.070.875|C16.320.365.826	Thalassemia	A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.	""	0	#FFFFFF
D013796	C05.116.099.343.110.500|C05.116.099.708.017.500|C05.660.585.984|C16.131.621.585.984|C16.320.240.500.500|C16.614.890	Thanatophoric Dysplasia	A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.	""	0	#FFFFFF
D013798	C04.557.475.750.875|C04.588.322.455.765|C12.050.351.500.056.630.705.765|C12.050.351.937.418.685.765|C12.100.250.056.630.705.765|C12.900.418.685.765|C19.344.410.765|C19.391.630.705.765	Thecoma	A gonadal stromal neoplasm composed only of THECA CELLS, occurring mostly in the postmenopausal OVARY. It is filled with lipid-containing spindle cells and produces ESTROGENS that can lead to ENDOMETRIAL HYPERPLASIA; UTERINE HEMORRHAGE; or other malignancies in postmenopausal women and sexual precocity in girls. When tumors containing theca cells also contain FIBROBLASTS, they are identified as thecoma-fibroma tumors with less active hormone production.	""	0	#FFFFFF
D013801	C01.610.701.688.735|C01.610.752.625.735|C01.610.752.750|C01.920.930.915|C22.196.831|C22.674.710.735	Theileriasis	Infection of cattle, sheep, or goats with protozoa of the genus THEILERIA. This infection results in an acute or chronic febrile condition.	""	0	#FFFFFF
D013832	C18.654.521.500.133.699.827	Thiamine Deficiency	A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)	""	0	#FFFFFF
D013851	C23.888.144.828	Thinness	A state of insufficient flesh on the body usually defined as having a body weight less than skeletal and physical standards. Depending on age, sex, and genetic background, a BODY MASS INDEX of less than 18.5 is considered as underweight.	""	0	#FFFFFF
D013896	C08.846	Thoracic Diseases	Disorders affecting the organs of the thorax.	""	0	#FFFFFF
D013898	C26.891	Thoracic Injuries	General or unspecified injuries to the chest area.	""	0	#FFFFFF
D013899	C04.588.894	Thoracic Neoplasms	New abnormal growth of tissue in the THORAX.	""	0	#FFFFFF
D013901	C10.668.829.550.850|C14.907.863	Thoracic Outlet Syndrome	A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).	""	0	#FFFFFF
D013915	C15.378.100.100.820|C15.378.140.810|C15.378.463.810|C16.320.099.820	Thrombasthenia	A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).	""	0	#FFFFFF
D013919	C14.907.137.870|C14.907.940.905	Thromboangiitis Obliterans	A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.	""	0	#FFFFFF
D013920	C15.378.100.832|C15.378.140.860.800|C15.378.190.636.860.800|C15.378.463.825	Thrombocythemia, Essential	A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.	""	0	#FFFFFF
D013921	C15.378.140.855	Thrombocytopenia	A subnormal level of BLOOD PLATELETS.	""	0	#FFFFFF
D013922	C15.378.140.860|C15.378.190.636.860	Thrombocytosis	Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)	""	0	#FFFFFF
D013923	C14.907.355.590	Thromboembolism	Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.	""	0	#FFFFFF
D013924	C14.907.355.830.925.770|C14.907.617.718.788|C14.907.940.740.910	Thrombophlebitis	Inflammation of a vein associated with a blood clot (THROMBUS).	""	0	#FFFFFF
D013927	C14.907.355.830	Thrombosis	Formation and development of a thrombus or blood clot in the blood vessel.	""	0	#FFFFFF
D013945	C04.557.435.850|C04.588.894.949.500|C15.604.861.800	Thymoma	A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)	""	0	#FFFFFF
D013952	C15.604.816	Thymus Hyperplasia	Enlargement of the thymus. A condition described in the late 1940's and 1950's as pathological thymic hypertrophy was status thymolymphaticus and was treated with radiotherapy. Unnecessary removal of the thymus was also practiced. It later became apparent that the thymus undergoes normal physiological hypertrophy, reaching a maximum at puberty and involuting thereafter. The concept of status thymolymphaticus has been abandoned. Thymus hyperplasia is present in two thirds of all patients with myasthenia gravis. (From Segen, Dictionary of Modern Medicine, 1992; Cecil Textbook of Medicine, 19th ed, p1486)	""	0	#FFFFFF
D013953	C04.588.894.949|C15.604.861	Thymus Neoplasms	Tumors or cancer of the THYMUS GLAND.	""	0	#FFFFFF
D013955	C04.182.902	Thyroglossal Cyst	A cyst in the neck caused by persistence of portions of, or by lack of closure of, the primitive thyroglossal duct. (Dorland, 27th ed)	""	0	#FFFFFF
D013958	C19.874.397.685.905	Thyroid Crisis	A dangerous life-threatening hypermetabolic condition characterized by high FEVER and dysfunction of the cardiovascular, the nervous, and the gastrointestinal systems.	""	0	#FFFFFF
D013959	C19.874	Thyroid Diseases	Pathological processes involving the THYROID GLAND.	""	0	#FFFFFF
D013964	C04.588.322.894|C04.588.443.915|C19.344.894|C19.874.788	Thyroid Neoplasms	Tumors or cancer of the THYROID GLAND.	""	0	#FFFFFF
D013966	C19.874.871	Thyroiditis	Inflammatory diseases of the THYROID GLAND. Thyroiditis can be classified into acute (THYROIDITIS, SUPPURATIVE), subacute (granulomatous and lymphocytic), chronic fibrous (Riedel's), chronic lymphocytic (HASHIMOTO DISEASE), transient (POSTPARTUM THYROIDITIS), and other AUTOIMMUNE THYROIDITIS subtypes.	""	0	#FFFFFF
D013967	C19.874.871.102|C20.111.809	Thyroiditis, Autoimmune	Inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-CELLS and thyroid AUTOANTIBODIES. The clinical signs can range from HYPOTHYROIDISM to THYROTOXICOSIS depending on the type of autoimmune thyroiditis.	""	0	#FFFFFF
D013968	C19.874.871.900	Thyroiditis, Subacute	Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection.	""	0	#FFFFFF
D013969	C01.830.840|C19.874.871.910	Thyroiditis, Suppurative	Acute inflammatory disease of the THYROID GLAND due to infections by BACTERIA; FUNGI; or other microorganisms. Symptoms include tender swelling, FEVER, and often with LEUKOCYTOSIS.	""	0	#FFFFFF
D013971	C19.874.397.685	Thyrotoxicosis	A hypermetabolic syndrome caused by excess THYROID HORMONES which may come from endogenous or exogenous sources. The endogenous source of hormone may be thyroid HYPERPLASIA; THYROID NEOPLASMS; or hormone-producing extrathyroidal tissue. Thyrotoxicosis is characterized by NERVOUSNESS; TACHYCARDIA; FATIGUE; WEIGHT LOSS; heat intolerance; and excessive SWEATING.	""	0	#FFFFFF
D013978	C26.404.875|C26.558.857	Tibial Fractures	Fractures of the TIBIA.	""	0	#FFFFFF
D013981	C10.228.662.825	Tic Disorders	Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)	""	0	#FFFFFF
D013984	C01.610.858.211.857	Tick Infestations	Infestations with soft-bodied (Argasidae) or hard-bodied (Ixodidae) ticks.	""	0	#FFFFFF
D013985	C25.723.127.789.500.707	Tick Paralysis	Paralysis caused by a neurotropic toxin secreted by the salivary glands of ticks.	""	0	#FFFFFF
D013986	C25.723.127.789.500	Tick Toxicoses	Toxicoses caused by toxic substances secreted by the salivary glands of ticks; include tick paralysis (neurotropic toxin), sweating sickness (dermotropic toxin), and Rhipicephalus appendiculatus toxicosis (leukotropic toxin).	""	0	#FFFFFF
D013991	C05.182.790|C17.300.182.790	Tietze's Syndrome	Idiopathic painful nonsuppurative swellings of one or more costal cartilages, especially of the second rib. The anterior chest pain may mimic that of coronary artery disease. (Dorland, 27th ed.)	""	0	#FFFFFF
D014005	C01.150.703.302.720|C01.800.200.720|C17.800.838.208.883	Tinea	Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.	""	0	#FFFFFF
D014006	C01.150.703.302.720.730|C01.800.200.720.730|C17.800.738.708|C17.800.838.208.883.558	Tinea Capitis	Ringworm of the scalp and associated hair mainly caused by species of MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON, which may occasionally involve the eyebrows and eyelashes.	""	0	#FFFFFF
D014007	C01.150.703.302.720.730.740|C01.800.200.720.730.740|C17.800.738.708.708|C17.800.838.208.883.558.708	Tinea Favosa	A disease of the scalp that may affect the glabrous skin and the nails and is recognized by the concave sulfur-yellow crusts that form around loose, wiry hairs. Atrophy ensues, leaving a smooth, glossy, thin, paper-white patch. This type of disease is rare in the United States and more frequently seen in the Middle East, Africa, Southeastern Europe, and other countries bordering the Mediterranean Sea. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p319)	""	0	#FFFFFF
D014008	C01.150.703.302.720.760|C01.800.200.720.760|C17.800.321.125.500|C17.800.838.208.883.658|C23.888.885.625.500	Tinea Pedis	Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.	""	0	#FFFFFF
D014009	C01.150.703.302.720.550|C01.800.200.720.550|C17.800.529.550|C17.800.838.208.883.458	Onychomycosis	A fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS.	""	0	#FFFFFF
D014010	C01.150.703.302.860|C01.800.200.860|C17.800.838.208.941	Tinea Versicolor	A common chronic, noninflammatory and usually symptomless disorder, characterized by the occurrence of multiple macular patches of all sizes and shapes, and varying in pigmentation from fawn-colored to brown. It is seen most frequently in hot, humid, tropical regions and is mostly caused by MALASSEZIA FURFUR (formerly Pityrosporum orbiculare).	""	0	#FFFFFF
D014012	C09.218.458.670|C10.597.751.418.670|C23.888.592.763.393.670	Tinnitus	A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.	""	0	#FFFFFF
D014029	C25.775.912	Tobacco Use Disorder	Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.	""	0	#FFFFFF
D014036	C01.925.782.930	Togaviridae Infections	Virus diseases caused by the TOGAVIRIDAE.	""	0	#FFFFFF
D014060	C07.465.910	Tongue Diseases	Diseases involving the TONGUE.	""	0	#FFFFFF
D014062	C04.588.443.591.925|C07.465.530.925|C07.465.910.470	Tongue Neoplasms	Tumors or cancer of the TONGUE.	""	0	#FFFFFF
D014063	C07.465.910.708	Tongue, Fissured	The occurrence of of breaks or slits in the tissue of the dorsal surface of the TONGUE.	""	0	#FFFFFF
D014064	C07.465.910.791	Tongue, Hairy	A benign condition of the tongue characterized by hypertrophy of the filiform papillae that give the dorsum of the tongue a furry appearance. The color of the elongated papillae varies from yellowish white to brown or black, depending upon staining by substances such as tobacco, food, or drugs. (Dorland, 27th ed)	""	0	#FFFFFF
D014067	C04.588.443.665.710.684.800|C07.550.745.671.800|C09.647.710.685.800|C09.775.549.685.800	Tonsillar Neoplasms	Tumors or cancer of the PALATINE TONSIL.	""	0	#FFFFFF
D014069	C01.748.561.750|C07.550.781.750|C08.730.561.750|C09.775.649.750	Tonsillitis	Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.	""	0	#FFFFFF
D014071	C07.650.800|C07.793.700|C16.131.850.800	Tooth Abnormalities	Congenital absence of or defects in structures of the teeth.	""	0	#FFFFFF
D014072	C07.793.818.124	Tooth Abrasion	The pathologic wearing away of the tooth substance by brushing, bruxism, clenching, and other mechanical causes. It is differentiated from TOOTH ATTRITION in that this type of wearing away is the result of tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces. It differs also from TOOTH EROSION, the progressive loss of the hard substance of a tooth by chemical processes not involving bacterial action. (From Jablonski, Dictionary of Dentistry, 1992, p2)	""	0	#FFFFFF
D014075	C07.793.735	Tooth Discoloration	Any change in the hue, color, or translucency of a tooth due to any cause. Restorative filling materials, drugs (both topical and systemic), pulpal necrosis, or hemorrhage may be responsible. (Jablonski, Dictionary of Dentistry, 1992, p253)	""	0	#FFFFFF
D014076	C07.793	Tooth Diseases	Diseases involving the TEETH.	""	0	#FFFFFF
D014077	C07.793.818.500	Tooth Erosion	Progressive loss of the hard substance of a tooth by chemical processes that do not involve bacterial action. (Jablonski, Dictionary of Dentistry, 1992, p296)	""	0	#FFFFFF
D014079	C07.793.790	Tooth Eruption, Ectopic	An abnormality in the direction of a TOOTH ERUPTION.	""	0	#FFFFFF
D014082	C07.793.850.750|C26.900.750	Tooth Fractures	Break or rupture of a tooth or tooth root.	""	0	#FFFFFF
D014084	C07.793.850.725|C26.900.725	Tooth Avulsion	Partial or complete displacement of a tooth from its alveolar support. It is commonly the result of trauma. (From Boucher's Clinical Dental Terminology, 4th ed, p312)	""	0	#FFFFFF
D014085	C07.465.714.836	Tooth Migration	The movement of teeth into altered positions in relationship to the basal bone of the ALVEOLAR PROCESS and to adjoining and opposing teeth as a result of loss of approximating or opposing teeth, occlusal interferences, habits, inflammatory and dystrophic disease of the attaching and supporting structures of the teeth. (From Boucher's Clinical Dental Terminology, 4th ed)	""	0	#FFFFFF
D014086	C07.465.714.898	Tooth Mobility	Horizontal and, to a lesser degree, axial movement of a tooth in response to normal forces, as in occlusion. It refers also to the movability of a tooth resulting from loss of all or a portion of its attachment and supportive apparatus, as seen in periodontitis, occlusal trauma, and periodontosis. (From Jablonski, Dictionary of Dentistry, 1992, p507 & Boucher's Clinical Dental Terminology, 4th ed, p313)	""	0	#FFFFFF
D014091	C07.793.901	Tooth Resorption	Resorption of calcified dental tissue, involving demineralization due to reversal of the cation exchange and lacunar resorption by osteoclasts. There are two types: external (as a result of tooth pathology) and internal (apparently initiated by a peculiar inflammatory hyperplasia of the pulp). (From Jablonski, Dictionary of Dentistry, 1992, p676)	""	0	#FFFFFF
D014095	C07.793.905	Tooth, Impacted	A tooth that is prevented from erupting by a physical barrier, usually other teeth. Impaction may also result from orientation of the tooth in an other than vertical position in the periodontal structures.	""	0	#FFFFFF
D014096	C07.650.800.850|C07.793.700.850|C16.131.850.800.850	Tooth, Supernumerary	An extra tooth, erupted or unerupted, resembling or unlike the other teeth in the group to which it belongs. Its presence may cause malposition of adjacent teeth or prevent their eruption.	""	0	#FFFFFF
D014097	C07.793.915	Tooth, Unerupted	A normal developing tooth which has not yet perforated the oral mucosa or one that fails to erupt in the normal sequence or time interval expected for the type of tooth in a given gender, age, or population group.	""	0	#FFFFFF
D014098	C07.793.929|C23.888.592.612.330.500	Toothache	Pain in the adjacent areas of the teeth.	""	0	#FFFFFF
D014102	C23.300.970	Torsion Abnormality	An abnormal twisting or rotation of a bodily part or member on its axis.	""	0	#FFFFFF
D014103	C23.888.592.350.300.800	Torticollis	A symptom, not a disease, of a twisted neck. In most instances, the head is tipped toward one side and the chin rotated toward the other. The involuntary muscle contractions in the neck region of patients with torticollis can be due to congenital defects, trauma, inflammation, tumors, and neurological or other factors.	""	0	#FFFFFF
D014115	C01.861	Toxemia	A condition produced by the presence of toxins or other harmful substances in the BLOOD.	""	0	#FFFFFF
D014120	C01.610.335.349.868|C01.610.335.508.700.100.868|C01.610.701.377.868|C22.674.377.868	Toxocariasis	Infection by round worms of the genus TOXOCARA, usually found in wild and domesticated cats and dogs and foxes, except for the larvae, which may produce visceral and ocular larva migrans in man.	""	0	#FFFFFF
D014123	C01.610.752.250.800	Toxoplasmosis	The acquired form of infection by Toxoplasma gondii in animals and man.	""	0	#FFFFFF
D014124	C01.610.701.688.817|C01.610.752.250.800.110|C01.610.752.625.817|C22.674.710.817	Toxoplasmosis, Animal	Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.	""	0	#FFFFFF
D014125	C01.207.205.300.900|C01.610.752.250.800.445|C10.228.228.205.300.900|C16.614.909	Toxoplasmosis, Congenital	Prenatal protozoal infection with TOXOPLASMA gondii which is associated with injury to the developing fetal nervous system. The severity of this condition is related to the stage of pregnancy during which the infection occurs; first trimester infections are associated with a greater degree of neurologic dysfunction. Clinical features include HYDROCEPHALUS; MICROCEPHALY; deafness; cerebral calcifications; SEIZURES; and psychomotor retardation. Signs of a systemic infection may also be present at birth, including fever, rash, and hepatosplenomegaly. (From Adams et al., Principles of Neurology, 6th ed, p735)	""	0	#FFFFFF
D014126	C01.610.300.781|C01.610.752.250.800.640|C11.294.725.781	Toxoplasmosis, Ocular	Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.	""	0	#FFFFFF
D014133	C08.907	Tracheal Diseases	Diseases involving the TRACHEA.	""	0	#FFFFFF
D014134	C04.588.443.925|C04.588.894.797.760|C08.785.760|C08.907.563	Tracheal Neoplasms	New abnormal growth of tissue in the TRACHEA.	""	0	#FFFFFF
D014135	C08.907.663	Tracheal Stenosis	A pathological narrowing of the TRACHEA.	""	0	#FFFFFF
D014136	C01.748.848|C08.730.848|C08.907.763	Tracheitis	INFLAMMATION of the TRACHEA that is usually associated with RESPIRATORY TRACT INFECTIONS.	""	0	#FFFFFF
D014137	C08.127.930|C08.695.830|C08.907.830|C16.131.740.830	Tracheobronchomegaly	A rare and probably congenital condition characterized by great enlargement of the lumen of the trachea and the larger bronchi.	""	0	#FFFFFF
D014138	C06.267.250.725|C06.405.117.367.725|C08.702.750|C08.907.863|C23.300.575.185.250.725	Tracheoesophageal Fistula	Abnormal passage between the ESOPHAGUS and the TRACHEA, acquired or congenital, often associated with ESOPHAGEAL ATRESIA.	""	0	#FFFFFF
D014141	C01.150.252.289.225.800|C01.150.252.400.210.125.745|C01.375.354.220.800|C11.187.183.220.889|C11.204.813|C11.294.354.220.800	Trachoma	A chronic infection of the CONJUNCTIVA and CORNEA caused by CHLAMYDIA TRACHOMATIS.	""	0	#FFFFFF
D014178	C23.550.210.870	Translocation, Genetic	A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.	""	0	#FFFFFF
D014188	C14.240.400.915|C14.280.400.915|C16.131.240.400.915	Transposition of Great Vessels	A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.	""	0	#FFFFFF
D014201	C01.610.335.865	Trematode Infections	Infections caused by infestation with worms of the class Trematoda.	""	0	#FFFFFF
D014202	C10.597.350.850|C23.888.592.350.850	Tremor	Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.	""	0	#FFFFFF
D014205	C01.150.252.400.126.100.800	Trench Fever	An intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by BARTONELLA QUINTANA and transmitted by the human louse.	""	0	#FFFFFF
D014211	C01.150.252.400.794.840|C01.150.252.400.840	Treponemal Infections	Infections with bacteria of the genus TREPONEMA.	""	0	#FFFFFF
D014235	C01.610.335.508.100.275.882	Trichinellosis	An infection with TRICHINELLA. It is caused by eating raw or undercooked meat that is infected with larvae of nematode worms TRICHINELLA genus. All members of the TRICHINELLA genus can infect human in addition to TRICHINELLA SPIRALIS, the traditional etiological agent. It is distributed throughout much of the world and is re-emerging in some parts as a public health hazard and a food safety problem.	""	0	#FFFFFF
D014245	C01.610.752.890	Trichomonas Infections	Infections in birds and mammals produced by various species of Trichomonas.	""	0	#FFFFFF
D014247	C01.610.752.890.633|C12.050.351.500.894.906.633|C12.100.250.894.906.633	Trichomonas Vaginitis	Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.	""	0	#FFFFFF
D014252	C01.610.335.508.700.775.825	Trichostrongyloidiasis	Infection by roundworms of the superfamily TRICHOSTRONGYLOIDEA, including the genera TRICHOSTRONGYLUS; OSTERTAGIA; Cooperia, HAEMONCHUS; Nematodirus, Hyostrongylus, and DICTYOCAULUS.	""	0	#FFFFFF
D014253	C01.610.335.508.700.775.825.842	Trichostrongylosis	Infestation with nematode worms of the genus TRICHOSTRONGYLUS. Man and animals become infected by swallowing larvae, usually with contaminated food or drink, although the larvae may penetrate human skin.	""	0	#FFFFFF
D014257	C01.610.335.508.100.275.895	Trichuriasis	Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.	""	0	#FFFFFF
D014262	C14.280.484.856	Tricuspid Valve Insufficiency	Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.	""	0	#FFFFFF
D014263	C14.280.484.400.875	Tricuspid Valve Prolapse	Abnormal protrusion of one or more of the leaflets of TRICUSPID VALVE into the RIGHT ATRIUM during SYSTOLE. This allows the backflow of blood into right atrium leading to TRICUSPID VALVE INSUFFICIENCY; SYSTOLIC MURMURS. Its most common cause is not primary valve abnormality but rather the dilation of the RIGHT VENTRICLE and the tricuspid annulus.	""	0	#FFFFFF
D014264	C14.280.484.911	Tricuspid Valve Stenosis	The pathologic narrowing of the orifice of the TRICUSPID VALVE. This hinders the emptying of RIGHT ATRIUM leading to elevated right atrial pressure and systemic venous congestion. Tricuspid valve stenosis is almost always due to RHEUMATIC FEVER.	""	0	#FFFFFF
D014277	C07.465.299.625.500.700|C10.292.319.625.700.700	Trigeminal Neuralgia	A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)	""	0	#FFFFFF
D014286	C14.240.400.960|C14.280.400.960|C16.131.240.400.960	Trilogy of Fallot	A combination of congenital heart defects consisting of three key features including ATRIAL SEPTAL DEFECTS; PULMONARY STENOSIS; and RIGHT VENTRICULAR HYPERTROPHY.	""	0	#FFFFFF
D014313	C10.597.613.750.700|C23.888.592.608.750.700	Trismus	Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, including TETANUS, as a complication of radiation therapy, trauma, or in association with neoplastic conditions.	""	0	#FFFFFF
D014314	C23.550.210.050.750|C23.550.210.182.500	Trisomy	The possession of a third chromosome of any one type in an otherwise diploid cell.	""	0	#FFFFFF
D014323	C01.610.858.211.480.869	Trombiculiasis	Infestation with mites of the genus Trombicula, whose larvae carry the rickettsial agent of scrub typhus.	""	0	#FFFFFF
D014328	C04.557.465.955|C04.850.908|C12.050.703.720.949	Trophoblastic Neoplasms	Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)	""	0	#FFFFFF
D014339	C14.240.400.560.098.500|C14.280.400.560.098.500|C16.131.240.400.560.098.500	Truncus Arteriosus, Persistent	A congenital anomaly caused by the failed development of TRUNCUS ARTERIOSUS into separate AORTA and PULMONARY ARTERY. It is characterized by a single arterial trunk that forms the outlet for both HEART VENTRICLES and gives rise to the systemic, pulmonary, and coronary arteries. It is always accompanied by a ventricular septal defect.	""	0	#FFFFFF
D014352	C01.610.752.300.900	Trypanosomiasis	Infection with protozoa of the genus TRYPANOSOMA.	""	0	#FFFFFF
D014353	C01.610.752.300.900.719|C01.920.937	Trypanosomiasis, African	"A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces ""African sleeping sickness."" Nagana is a rapidly fatal trypanosomiasis of horses and other animals."	""	0	#FFFFFF
D014354	C01.610.701.688.896|C01.610.752.300.900.802|C01.610.752.625.896|C22.196.888|C22.674.710.896	Trypanosomiasis, Bovine	Infection in cattle caused by various species of trypanosomes.	""	0	#FFFFFF
D014355	C01.610.752.300.900.200|C01.920.625	Chagas Disease	Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	""	0	#FFFFFF
D014375	C01.150.252.410.040.552.846.493	Tuberculoma	A tumor-like mass resulting from the enlargement of a tuberculous lesion.	""	0	#FFFFFF
D014376	C01.150.252.410.040.552.846	Tuberculosis	Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	""	0	#FFFFFF
D014379	C01.150.252.410.040.552.846.516|C22.131.921	Tuberculosis, Avian	A variety of TUBERCULOSIS affecting various birds, including chickens and ducks. It is caused by MYCOBACTERIUM AVIUM and characterized by tubercles consisting principally of epithelioid cells.	""	0	#FFFFFF
D014380	C01.150.252.410.040.552.846.538|C22.196.927	Tuberculosis, Bovine	An infection of cattle caused by MYCOBACTERIUM BOVIS. It is transmissible to man and other animals.	""	0	#FFFFFF
D014381	C01.150.252.410.040.552.846.554|C01.190.750|C14.260.750	Tuberculosis, Cardiovascular	Pathological conditions of the CARDIOVASCULAR SYSTEM caused by infection of MYCOBACTERIUM TUBERCULOSIS. Tuberculosis involvement may include the HEART; the BLOOD VESSELS; or the PERICARDIUM.	""	0	#FFFFFF
D014382	C01.150.252.410.040.552.846.588|C01.150.252.819.820|C01.800.720.820|C17.800.838.765.820	Tuberculosis, Cutaneous	Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.	""	0	#FFFFFF
D014383	C01.150.252.410.040.552.846.606|C19.927	Tuberculosis, Endocrine	Infection of the ENDOCRINE GLANDS with species of MYCOBACTERIUM, most often MYCOBACTERIUM TUBERCULOSIS.	""	0	#FFFFFF
D014384	C01.150.252.410.040.552.846.944.596|C12.050.351.500.758|C12.050.351.750.940|C12.100.250.758|C12.600.940	Tuberculosis, Female Genital	MYCOBACTERIUM infections of the female reproductive tract (GENITALIA, FEMALE).	""	0	#FFFFFF
D014385	C01.150.252.410.040.552.846.628|C06.405.874	Tuberculosis, Gastrointestinal	TUBERCULOSIS that involves any region of the GASTROINTESTINAL TRACT, mostly in the distal ILEUM and the CECUM. In most cases, MYCOBACTERIUM TUBERCULOSIS is the pathogen. Clinical features include ABDOMINAL PAIN; FEVER; and palpable mass in the ileocecal area.	""	0	#FFFFFF
D014386	C01.150.252.410.040.552.846.651|C06.552.933	Tuberculosis, Hepatic	Infection of the LIVER with species of MYCOBACTERIUM, most often MYCOBACTERIUM TUBERCULOSIS. It is characterized by localized small tuberculous miliary lesions or tumor-like mass (TUBERCULOMA), and abnormalities in liver function tests.	""	0	#FFFFFF
D014387	C01.150.252.410.040.552.846.696|C01.748.860|C08.360.860|C08.730.860|C09.400.860	Tuberculosis, Laryngeal	Tuberculosis involving the larynx, producing ulceration of the VOCAL CORDS and the LARYNGEAL MUCOSA.	""	0	#FFFFFF
D014388	C01.150.252.410.040.552.846.719	Tuberculosis, Lymph Node	Infection of the lymph nodes by tuberculosis. Tuberculous infection of the cervical lymph nodes is scrofula.	""	0	#FFFFFF
D014389	C01.150.252.410.040.552.846.944.721|C12.100.500.909|C12.200.294.909|C12.200.672.721|C12.600.955	Tuberculosis, Male Genital	MYCOBACTERIUM infections of the male reproductive tract (GENITALIA, MALE).	""	0	#FFFFFF
D014390	C01.150.252.223.500.937|C01.150.252.223.850.800|C01.150.252.410.040.552.846.570.600|C01.207.180.500.937|C01.207.180.850.800|C10.228.228.180.500.937|C10.228.228.180.850.800|C10.586.625.280.915	Tuberculosis, Meningeal	A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)	""	0	#FFFFFF
D014391	C01.150.252.410.040.552.846.764	Tuberculosis, Miliary	An acute form of TUBERCULOSIS in which minute tubercles are formed in a number of organs of the body due to dissemination of the bacilli through the blood stream.	""	0	#FFFFFF
D014392	C01.150.252.289.800|C01.375.354.800|C11.294.354.800	Tuberculosis, Ocular	Tuberculous infection of the eye, primarily the iris, ciliary body, and choroid.	""	0	#FFFFFF
D014393	C01.150.252.410.040.552.846.809|C07.465.943	Tuberculosis, Oral	Tuberculosis of the mouth, tongue, and salivary glands.	""	0	#FFFFFF
D014394	C01.150.252.410.040.552.846.843|C01.160.886|C05.116.165.886	Tuberculosis, Osteoarticular	Tuberculosis of the bones or joints.	""	0	#FFFFFF
D014395	C01.150.252.410.040.552.846.308|C01.463.600.249|C06.844.640.249	Peritonitis, Tuberculous	A form of PERITONITIS seen in patients with TUBERCULOSIS, characterized by lesion either as a miliary form or as a pelvic mass on the peritoneal surfaces. Most patients have ASCITES, abdominal swelling, ABDOMINAL PAIN, and other systemic symptoms such as FEVER; WEIGHT LOSS; and ANEMIA.	""	0	#FFFFFF
D014396	C01.150.252.410.040.552.846.877|C01.748.912|C08.528.928|C08.730.912	Tuberculosis, Pleural	Tuberculosis of the serous membrane lining the thoracic cavity and surrounding the lungs.	""	0	#FFFFFF
D014397	C01.150.252.410.040.552.846.899|C01.748.939|C08.381.922|C08.730.939	Tuberculosis, Pulmonary	MYCOBACTERIUM infections of the lung.	""	0	#FFFFFF
D014398	C01.150.252.410.040.552.846.944.847|C12.050.351.750.970|C12.050.351.968.419.912|C12.200.672.847|C12.200.777.419.912|C12.600.970|C12.950.419.912	Tuberculosis, Renal	Infection of the KIDNEY with species of MYCOBACTERIUM.	""	0	#FFFFFF
D014399	C01.150.252.410.040.552.846.843.722|C01.160.886.722|C05.116.165.886.722|C05.116.900.853.850	Tuberculosis, Spinal	Osteitis or caries of the vertebrae, usually occurring as a complication of tuberculosis of the lungs.	""	0	#FFFFFF
D014400	C01.150.252.410.040.552.846.922|C15.604.744.909	Tuberculosis, Splenic	Infection of the spleen with species of MYCOBACTERIUM.	""	0	#FFFFFF
D014401	C01.150.252.410.040.552.846.944|C12.050.351.750|C12.200.672|C12.600	Tuberculosis, Urogenital	A general term for MYCOBACTERIUM infections of any part of the UROGENITAL SYSTEM in either the male or the female.	""	0	#FFFFFF
D014402	C04.445.810|C04.651.800|C04.700.700|C10.500.507.400.750|C10.562.850|C10.574.500.865|C16.131.666.507.400.750|C16.320.400.880|C16.320.700.700	Tuberous Sclerosis	Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.	""	0	#FFFFFF
D014406	C01.150.252.400.900|C01.920.930.943	Tularemia	A plague-like disease of rodents, transmissible to man. It is caused by FRANCISELLA TULARENSIS and is characterized by fever, chills, headache, backache, and weakness.	""	0	#FFFFFF
D014412	C01.925.928	Tumor Virus Infections	Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.	""	0	#FFFFFF
D014424	C12.050.351.875.253.309.872|C12.050.351.875.253.795.750|C12.200.706.316.309.872|C12.200.706.316.795.750|C12.800.316.309.872|C12.800.316.795.750|C14.240.400.980|C14.280.400.980|C16.131.240.400.970|C16.131.260.830.835.750|C16.131.939.316.309.872|C16.131.939.316.795.750|C16.320.180.830.835.750|C19.391.119.309.872|C19.391.119.795.750	Turner Syndrome	A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.	""	0	#FFFFFF
D014428	C16.131.085.806	Twins, Conjoined	MONOZYGOTIC TWINS who are joined in utero. They may be well developed and share only a superficial connection, often in the frontal, transverse or sagittal body plane, or they may share a partial duplication of a body structure. Alternatively, there may be a small and incompletely developed twin conjoined to a larger, more fully developed twin.	""	0	#FFFFFF
D014435	C01.150.252.400.310.821.873	Typhoid Fever	An acute systemic febrile infection caused by SALMONELLA TYPHI, a serotype of SALMONELLA ENTERICA.	""	0	#FFFFFF
D014437	C01.150.252.400.789.725.800|C01.920.914.725.800	Typhus, Endemic Flea-Borne	An infectious disease clinically similar to epidemic louse-borne typhus (TYPHUS, EPIDEMIC LOUSE-BORNE), but caused by RICKETTSIA TYPHI, which is transmitted from rat to man by the rat flea, XENOPSYLLA CHEOPIS.	""	0	#FFFFFF
D014438	C01.150.252.400.789.725.805|C01.920.914.725.805	Typhus, Epidemic Louse-Borne	The classic form of typhus, caused by RICKETTSIA PROWAZEKII, which is transmitted from man to man by the louse Pediculus humanus corporis. This disease is characterized by the sudden onset of intense headache, malaise, and generalized myalgia followed by the formation of a macular skin eruption and vascular and neurologic disturbances.	""	0	#FFFFFF
D014456	C23.550.891	Ulcer	A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.	""	0	#FFFFFF
D014458	C26.088.268.807|C26.404.937	Ulna Fractures	Fractures of the larger bone of the forearm.	""	0	#FFFFFF
D014474	C10.597.606.358.800|C23.888.592.604.359.800	Unconsciousness	Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)	""	0	#FFFFFF
D014496	C04.182.946	Urachal Cyst	Cyst occurring in a persistent portion of the urachus, presenting as an extraperitoneal mass in the umbilical region. It is characterized by abdominal pain, and fever if infected. It may rupture, leading to peritonitis, or it may drain through the umbilicus.	""	0	#FFFFFF
D014511	C12.050.351.968.419.936|C12.200.777.419.936|C12.950.419.936	Uremia	A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	""	0	#FFFFFF
D014514	C12.050.351.968.725.938.500|C12.050.351.968.967.374.500|C12.050.351.968.967.500.851|C12.200.777.725.938.500|C12.200.777.967.374.500|C12.200.777.967.500.851|C12.950.725.938.500|C12.950.967.374.500|C12.950.967.500.851|C23.300.175.850.750	Ureteral Calculi	Stones in the URETER that are formed in the KIDNEY. They are rarely more than 5 mm in diameter for larger renal stones cannot enter ureters. They are often lodged at the ureteral narrowing and can cause excruciating renal colic.	""	0	#FFFFFF
D014515	C12.050.351.968.725|C12.200.777.725|C12.950.725	Ureteral Diseases	Pathological processes involving the URETERS.	""	0	#FFFFFF
D014516	C04.588.945.947.940|C12.050.351.937.820.875|C12.050.351.968.725.676|C12.200.758.820.875|C12.200.777.725.676|C12.900.820.875|C12.950.725.676|C12.950.983.875	Ureteral Neoplasms	Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.	""	0	#FFFFFF
D014517	C12.050.351.968.725.776|C12.200.777.725.776|C12.950.725.776	Ureteral Obstruction	Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.	""	0	#FFFFFF
D014518	C12.050.351.968.725.876|C12.200.777.725.876|C12.950.725.876	Ureterocele	A cystic dilatation of the end of a URETER as it enters into the URINARY BLADDER. It is characterized by the ballooning of the ureteral orifice into the lumen of the bladder and may obstruct urine flow.	""	0	#FFFFFF
D014522	C12.050.351.968.767|C12.200.777.767|C12.950.767	Urethral Diseases	Pathological processes involving the URETHRA.	""	0	#FFFFFF
D014523	C04.588.945.947.945|C12.050.351.937.820.890|C12.050.351.968.767.601|C12.200.758.820.937|C12.200.777.767.601|C12.900.820.890|C12.950.767.601|C12.950.983.890	Urethral Neoplasms	Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.	""	0	#FFFFFF
D014524	C12.050.351.968.767.700|C12.200.777.767.700|C12.950.767.700	Urethral Obstruction	Partial or complete blockage in any part of the URETHRA that can lead to difficulty or inability to empty the URINARY BLADDER. It is characterized by an enlarged, often damaged, bladder with frequent urges to void.	""	0	#FFFFFF
D014525	C12.050.351.968.767.700.700|C12.200.777.767.700.700|C12.950.767.700.700	Urethral Stricture	Narrowing of any part of the URETHRA. It is characterized by decreased urinary stream and often other obstructive voiding symptoms.	""	0	#FFFFFF
D014526	C12.050.351.968.767.851|C12.200.777.767.851|C12.950.767.851	Urethritis	Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.	""	0	#FFFFFF
D014545	C12.050.351.968.967.500|C12.200.777.967.500|C12.950.967.500|C23.300.175.850	Urinary Calculi	Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.	""	0	#FFFFFF
D014548	C12.050.351.875.881|C12.200.706.881|C12.800.881|C23.300.575.825	Urinary Fistula	An abnormal passage in any part of the URINARY TRACT between itself or with other organs.	""	0	#FFFFFF
D014549	C12.050.351.968.934.814|C12.200.777.934.852|C12.950.934.814|C23.888.942.343.800	Urinary Incontinence	Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types of incontinence include URINARY URGE INCONTINENCE and URINARY STRESS INCONTINENCE.	""	0	#FFFFFF
D014550	C12.050.351.968.934.814.500|C12.200.777.934.852.249|C12.950.934.814.500|C23.888.942.343.800.500	Urinary Incontinence, Stress	Involuntary discharge of URINE as a result of physical activities that increase abdominal pressure on the URINARY BLADDER without detrusor contraction or overdistended bladder. The subtypes are classified by the degree of leakage, descent and opening of the bladder neck and URETHRA without bladder contraction, and sphincter deficiency.	""	0	#FFFFFF
D014552	C01.915|C12.050.351.968.892|C12.200.777.892|C12.950.892	Urinary Tract Infections	Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	""	0	#FFFFFF
D014555	C12.050.351.968.934|C12.200.777.934|C12.950.934	Urination Disorders	Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.	""	0	#FFFFFF
D014564	C12.050.351.875|C12.200.706|C12.800|C16.131.939	Urogenital Abnormalities	Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.	""	0	#FFFFFF
D014565	C04.588.945|C12.050.351.937|C12.200.758|C12.900	Urogenital Neoplasms	Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.	""	0	#FFFFFF
D014570	C12.050.351.968|C12.200.777|C12.950	Urologic Diseases	Pathological processes of the URINARY TRACT in both males and females.	""	0	#FFFFFF
D014571	C04.588.945.947|C12.050.351.937.820|C12.200.758.820|C12.900.820|C12.950.983	Urologic Neoplasms	Tumors or cancer of the URINARY TRACT in either the male or the female.	""	0	#FFFFFF
D014581	C17.800.862.945|C20.543.480.904	Urticaria	A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.	""	0	#FFFFFF
D014582	C04.557.450.565.465.500.850|C04.588.805.309.850|C17.800.621.893|C17.800.882.356.850|C20.762.750.563.850	Urticaria Pigmentosa	The most common form of cutaneous mastocytosis (MASTOCYTOSIS, CUTANEOUS) that occurs primarily in children. It is characterized by the multiple small reddish-brown pigmented pruritic macules and papules.	""	0	#FFFFFF
D014591	C12.050.351.500.852|C12.100.250.852	Uterine Diseases	Pathological processes involving any part of the UTERUS.	""	0	#FFFFFF
D014592	C12.050.351.500.852.691|C12.100.250.852.691|C23.550.414.993	Uterine Hemorrhage	Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.	""	0	#FFFFFF
D014593	C12.050.703.420.288.728	Uterine Inertia	Failure of the UTERUS to contract with normal strength, duration, and intervals during childbirth (LABOR, OBSTETRIC). It is also called uterine atony.	""	0	#FFFFFF
D014594	C04.588.945.418.948|C12.050.351.500.852.762|C12.050.351.937.418.875|C12.100.250.852.762|C12.900.418.875	Uterine Neoplasms	Tumors or cancer of the UTERUS.	""	0	#FFFFFF
D014595	C12.050.351.500.852.904.500|C12.100.250.852.904.500|C26.761.853.500	Uterine Perforation	A hole or break through the wall of the UTERUS, usually made by the placement of an instrument or INTRAUTERINE DEVICES.	""	0	#FFFFFF
D014596	C12.050.351.500.852.833|C12.100.250.852.833|C23.300.842.624.750	Uterine Prolapse	Downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.	""	0	#FFFFFF
D014597	C12.050.351.500.852.904|C12.050.703.420.904|C12.100.250.852.904|C26.761.853	Uterine Rupture	A complete separation or tear in the wall of the UTERUS with or without expulsion of the FETUS. It may be due to injuries, multiple pregnancies, large fetus, previous scarring, or obstruction.	""	0	#FFFFFF
D014603	C11.941	Uveal Diseases	Diseases of the uvea.	""	0	#FFFFFF
D014604	C04.588.364.978|C11.319.494|C11.941.855	Uveal Neoplasms	Tumors or cancer of the UVEA.	""	0	#FFFFFF
D014605	C11.941.879	Uveitis	Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)	""	0	#FFFFFF
D014606	C11.941.879.780.880	Uveitis, Anterior	Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.	""	0	#FFFFFF
D014607	C10.114.843|C11.941.879.980|C20.111.258.925	Uveomeningoencephalitic Syndrome	A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)	""	0	#FFFFFF
D014608	C15.604.515.827.865	Uveoparotid Fever	A manifestation of sarcoidosis marked by chronic inflammation of the parotid gland and the uvea.	""	0	#FFFFFF
D014615	C01.925.256.743.929	Vaccinia	The cutaneous and occasional systemic reactions associated with vaccination using smallpox (variola) vaccine.	""	0	#FFFFFF
D014623	C12.050.351.500.894|C12.100.250.894	Vaginal Diseases	Pathological processes of the VAGINA.	""	0	#FFFFFF
D014624	C12.050.351.500.894.767|C12.100.250.894.767|C23.300.575.925	Vaginal Fistula	An abnormal anatomical passage that connects the VAGINA to other organs, such as the bladder (VESICOVAGINAL FISTULA) or the rectum (RECTOVAGINAL FISTULA).	""	0	#FFFFFF
D014625	C04.588.945.418.955|C12.050.351.500.894.834|C12.050.351.937.418.937|C12.100.250.894.834|C12.900.418.937	Vaginal Neoplasms	Tumors or cancer of the VAGINA.	""	0	#FFFFFF
D014627	C12.050.351.500.894.906|C12.100.250.894.906	Vaginitis	Inflammation of the vagina characterized by pain and a purulent discharge.	""	0	#FFFFFF
D014646	C12.100.500.936|C12.200.294.936|C14.907.903	Varicocele	A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.	""	0	#FFFFFF
D014647	C14.907.927.730|C17.800.893.592.730	Varicose Ulcer	Skin breakdown or ulceration in the drainage area of a VARICOSE VEIN, usually in the leg.	""	0	#FFFFFF
D014648	C14.907.927	Varicose Veins	Enlarged and tortuous VEINS.	""	0	#FFFFFF
D014652	C14.907	Vascular Diseases	Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.	""	0	#FFFFFF
D014653	C10.228.140.300.800|C10.228.140.546.699.500|C14.907.253.937	Vascular Headaches	Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.	""	0	#FFFFFF
D014657	C14.907.940	Vasculitis	Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.	""	0	#FFFFFF
D014681	C07.465.525.955|C07.550.966|C07.650.525.955|C09.775.955|C16.131.850.525.955	Velopharyngeal Insufficiency	Failure of the SOFT PALATE to reach the posterior pharyngeal wall to close the opening between the oral and nasal cavities. Incomplete velopharyngeal closure is primarily related to surgeries (ADENOIDECTOMY; CLEFT PALATE) or an incompetent PALATOPHARYNGEAL SPHINCTER. It is characterized by hypernasal speech.	""	0	#FFFFFF
D014685	C04.588.945.956|C22.950	Venereal Tumors, Veterinary	Tumors most commonly seen on or near the genitalia. They are venereal, most likely transmitted through transplantation of cells by contact. Metastases have been reported. Spontaneous regression may occur.	""	0	#FFFFFF
D014689	C14.907.952	Venous Insufficiency	Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.	""	0	#FFFFFF
D014693	C14.280.067.922|C23.550.073.922	Ventricular Fibrillation	A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.	""	0	#FFFFFF
D014694	C14.280.955	Ventricular Outflow Obstruction	Occlusion of the outflow tract in either the LEFT VENTRICLE or the RIGHT VENTRICLE of the heart. This may result from CONGENITAL HEART DEFECTS, predisposing heart diseases, complications of surgery, or HEART NEOPLASMS.	""	0	#FFFFFF
D014715	C10.228.140.300.150.956|C14.907.253.092.956	Vertebrobasilar Insufficiency	Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.	""	0	#FFFFFF
D014717	C09.218.568.900.883|C10.597.951|C23.888.592.958	Vertigo	An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)	""	0	#FFFFFF
D014718	C12.050.351.968.829.920|C12.200.777.829.920|C12.950.829.920	Vesico-Ureteral Reflux	Retrograde flow of urine from the URINARY BLADDER into the URETER. This is often due to incompetence of the vesicoureteral valve leading to ascending bacterial infection into the KIDNEY.	""	0	#FFFFFF
D014719	C12.050.351.500.894.767.500|C12.050.351.875.881.312.733|C12.050.351.968.829.548.733|C12.100.250.894.767.500|C12.950.829.548.733|C23.300.575.825.250.775|C23.300.575.925.816	Vesicovaginal Fistula	An abnormal anatomical passage between the URINARY BLADDER and the VAGINA.	""	0	#FFFFFF
D014720	C01.925.782.160.927|C22.905.927	Vesicular Exanthema of Swine	A calicivirus infection of swine characterized by hydropic degeneration of the oral and cutaneous epithelia.	""	0	#FFFFFF
D014735	C01.150.252.400.959	Vibrio Infections	Infections with bacteria of the genus VIBRIO.	""	0	#FFFFFF
D014766	C01.925.937|C23.550.470.790.500.900	Viremia	The presence of viruses in the blood.	""	0	#FFFFFF
D014770	C23.888.971	Virilism	Development of male secondary SEX CHARACTERISTICS in the FEMALE. It is due to the effects of androgenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs.	""	0	#FFFFFF
D014777	C01.925	Virus Diseases	A general term for diseases caused by viruses.	""	0	#FFFFFF
D014782	C06.405.937|C23.300.842.624.875	Visceral Prolapse	The prolapse or downward displacement of the VISCERA.	""	0	#FFFFFF
D014786	C10.597.751.941|C11.966|C23.888.592.763.941	Vision Disorders	Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).	""	0	#FFFFFF
D014802	C18.654.521.500.133.628	Vitamin A Deficiency	A nutritional condition produced by a deficiency of VITAMIN A in the diet, characterized by NIGHT BLINDNESS and other ocular manifestations such as dryness of the conjunctiva and later of the cornea (XEROPHTHALMIA). Vitamin A deficiency is a very common problem worldwide, particularly in developing countries as a consequence of famine or shortages of vitamin A-rich foods. In the United States it is found among the urban poor, the elderly, alcoholics, and patients with malabsorption. (From Cecil Textbook of Medicine, 19th ed, p1179)	""	0	#FFFFFF
D014804	C18.654.521.500.133.699	Vitamin B Deficiency	A condition due to deficiency in any member of the VITAMIN B COMPLEX. These B vitamins are water-soluble and must be obtained from the diet because they are easily lost in the urine. Unlike the lipid-soluble vitamins, they cannot be stored in the body fat.	""	0	#FFFFFF
D014806	C18.654.521.500.133.699.923	Vitamin B 12 Deficiency	A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)	""	0	#FFFFFF
D014808	C18.654.521.500.133.770	Vitamin D Deficiency	A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)	""	0	#FFFFFF
D014811	C18.654.521.500.133.841	Vitamin E Deficiency	A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)	""	0	#FFFFFF
D014813	C15.378.100.920|C15.378.463.841|C18.654.521.500.133.912	Vitamin K Deficiency	A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)	""	0	#FFFFFF
D014820	C17.800.621.440.895	Vitiligo	A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.	""	0	#FFFFFF
D014823	C11.290.960|C23.550.414.756.887	Vitreous Hemorrhage	Hemorrhage into the VITREOUS BODY.	""	0	#FFFFFF
D014826	C08.360.931|C09.400.931|C10.292.887.800|C10.597.622.943|C23.888.592.636.943	Vocal Cord Paralysis	Congenital or acquired paralysis of one or both VOCAL CORDS. This condition is caused by defects in the CENTRAL NERVOUS SYSTEM, the VAGUS NERVE and branches of LARYNGEAL NERVES. Common symptoms are VOICE DISORDERS including HOARSENESS or APHONIA.	""	0	#FFFFFF
D014832	C08.360.940|C09.400.940|C10.597.975|C23.888.592.979	Voice Disorders	Pathological processes that affect voice production, usually involving VOCAL CORDS and the LARYNGEAL MUCOSA. Voice disorders can be caused by organic (anatomical), or functional (emotional or psychological) factors leading to DYSPHONIA; APHONIA; and defects in VOICE QUALITY, loudness, and pitch.	""	0	#FFFFFF
D014839	C23.888.821.937	Vomiting	The forcible expulsion of the contents of the STOMACH through the MOUTH.	""	0	#FFFFFF
D014840	C23.888.821.937.080	Vomiting, Anticipatory	Vomiting caused by expectation of discomfort or unpleasantness.	""	0	#FFFFFF
D014842	C15.378.100.100.900|C15.378.100.141.900|C15.378.140.900|C15.378.463.920|C16.320.099.920	von Willebrand Diseases	Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.	""	0	#FFFFFF
D014845	C12.050.351.500.944|C12.100.250.944	Vulvar Diseases	Pathological processes of the VULVA.	""	0	#FFFFFF
D014846	C04.588.945.418.968|C12.050.351.500.944.819|C12.050.351.937.418.968|C12.100.250.944.819|C12.900.418.968	Vulvar Neoplasms	Tumors or cancer of the VULVA.	""	0	#FFFFFF
D014847	C12.050.351.500.944.902|C12.100.250.944.902	Vulvitis	Inflammation of the VULVA. It is characterized by PRURITUS and painful urination.	""	0	#FFFFFF
D014848	C12.050.351.500.894.906.820|C12.050.351.500.944.902.737|C12.100.250.894.906.820|C12.100.250.944.902.737	Vulvovaginitis	Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.	""	0	#FFFFFF
D014849	C16.131.077.938	Waardenburg Syndrome	Rare, autosomal dominant disease with variable penetrance and several known clinical types. Characteristics may include depigmentation of the hair and skin, congenital deafness, heterochromia iridis, medial eyebrow hyperplasia, hypertrophy of the nasal root, and especially dystopia canthorum. The underlying cause may be defective development of the neural crest (neurocristopathy). Waardenburg's syndrome may be closely related to piebaldism. Klein-Waardenburg Syndrome refers to a disorder that also includes upper limb abnormalities.	""	0	#FFFFFF
D014854	C10.228.140.300.150.477.100.500|C10.228.140.300.775.200.100.500|C14.907.253.092.477.100.500|C14.907.253.855.200.100.500|C23.550.513.355.250.100.500|C23.550.717.489.250.100.500	Lateral Medullary Syndrome	INFARCTION of the dorsolateral aspect of MEDULLA OBLONGATA in the BRAIN STEM. It is caused by occlusion of the VERTEBRAL ARTERY and/or the posterior inferior cerebellar artery. Clinical manifestations vary with the size of infarction, but may include loss of pain and temperature sensation in the ipsilateral face and contralateral body below the chin; ipsilateral HORNER SYNDROME; ipsilateral ATAXIA; DYSARTHRIA; VERTIGO; nausea, hiccup; dysphagia; and VOCAL CORD PARALYSIS. (From Adams et al., Principles of Neurology, 6th ed, p801)	""	0	#FFFFFF
D014855	C23.550.737.750	Wallerian Degeneration	Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.	""	0	#FFFFFF
D014860	C01.925.256.650.810|C01.925.825.810|C01.925.928.914|C17.800.838.790.810	Warts	Benign epidermal proliferations or tumors; some are viral in origin.	""	0	#FFFFFF
D014869	C18.452.950.932|C25.723.932	Water Intoxication	A condition resulting from the excessive retention of water with sodium depletion.	""	0	#FFFFFF
D014883	C18.452.950	Water-Electrolyte Imbalance	Disturbances in the body's WATER-ELECTROLYTE BALANCE.	""	0	#FFFFFF
D014884	C01.150.252.223.500.750.500|C01.150.252.400.625.549.449.800|C01.207.180.500.750.500|C10.228.228.180.500.750.500|C10.586.625.280.505.904|C15.378.100.802.843|C15.378.463.950|C19.053.500.740|C23.550.414.950.843|C23.888.885.687.843	Waterhouse-Friderichsen Syndrome	A condition of HEMORRHAGE and NECROSIS of the ADRENAL GLAND. It is characterized by rapidly developing ADRENAL INSUFFICIENCY; HYPOTENSION; and widespread cutaneous PURPURA.	""	0	#FFFFFF
D014890	C08.381.483.950|C14.907.940.897.249.750|C20.111.193.875	Granulomatosis with Polyangiitis	A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.	""	0	#FFFFFF
D014895	C01.150.252.400.794.511.739	Weil Disease	A severe form of LEPTOSPIROSIS, usually caused by LEPTOSPIRA INTERROGANS SEROVAR ICTEROHAEMORRHAGIAE and occasionally other serovars. It is transmitted to humans by the rat and is characterized by hemorrhagic and renal symptoms with accompanying JAUNDICE.	""	0	#FFFFFF
D014897	C10.228.854.468.800|C10.574.500.812|C10.574.562.500.750|C10.668.467.500.750|C16.320.400.765	Spinal Muscular Atrophies of Childhood	A group of recessive inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3)	""	0	#FFFFFF
D014898	C16.320.925|C18.452.284.960	Werner Syndrome	An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease.	""	0	#FFFFFF
D014899	C10.228.140.163.960|C18.452.132.960|C18.654.521.500.133.699.827.822|C25.775.100.625	Wernicke Encephalopathy	An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)	""	0	#FFFFFF
D014901	C01.207.245.340.300.887|C01.207.399.750.300.887|C01.920.500.343.950|C01.925.081.343.950|C01.925.182.525.300.850|C01.925.782.310.950|C01.925.782.350.250.900|C10.228.140.430.520.750.300.887|C10.228.228.245.340.300.887|C10.228.228.399.750.300.887|C10.586.250.520.750.300.887	West Nile Fever	A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)	""	0	#FFFFFF
D014911	C26.700.500	Whiplash Injuries	Hyperextension injury to the neck, often the result of being struck from behind by a fast-moving vehicle, in an automobile accident. (From Segen, The Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D014912	C22.595.740	White Muscle Disease	A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)	""	0	#FFFFFF
D014917	C01.150.252.400.143.500|C01.748.969|C08.730.969	Whooping Cough	A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.	""	0	#FFFFFF
D014923	C15.378.100.100.970|C15.378.463.960|C15.378.553.546.605.900|C16.320.099.970|C16.320.322.937|C16.320.798.875|C20.673.627.900|C20.673.795.875	Wiskott-Aldrich Syndrome	A rare, X-linked immunodeficiency syndrome characterized by ECZEMA; LYMPHOPENIA; and, recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IMMUNOGLOBULIN M levels are low and IMMUNOGLOBULIN A and IMMUNOGLOBULIN E levels are elevated. Lymphoreticular malignancies are common.	""	0	#FFFFFF
D014924	C05.550.114.843.823|C05.799.825.823|C20.543.928	Wissler's Syndrome	A rheumatic syndrome of possibly allergic origin, usually affecting children and adolescents, and characterized by high fever, exanthema, arthralgia, leukocytosis, and increased sedimentation rate.	""	0	#FFFFFF
D014927	C14.280.067.780.977|C14.280.123.750.977|C16.131.240.400.980	Wolff-Parkinson-White Syndrome	A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.	""	0	#FFFFFF
D014929	C09.218.458.341.186.500.750|C10.292.700.225.500.980|C10.574.500.662.980|C10.597.751.418.341.186.500.750|C10.597.751.941.162.625.750|C11.270.564.980|C11.640.451.451.980|C11.966.075.375.750|C12.050.351.968.419.135.875|C12.200.777.419.135.875|C12.950.419.135.875|C16.131.077.299.750|C16.320.290.564.980|C16.320.400.630.980|C18.452.394.750.124.960|C19.246.267.960|C19.700.159.875	Wolfram Syndrome	A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.	""	0	#FFFFFF
D014946	C01.947	Wound Infection	Invasion of a wound by pathogenic microorganisms.	""	0	#FFFFFF
D014947	C26	Wounds and Injuries	Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.	""	0	#FFFFFF
D014948	C26.986.900	Wounds, Gunshot	Disruption of structural continuity of the body as a result of the discharge of firearms.	""	0	#FFFFFF
D014949	C26.974	Wounds, Nonpenetrating	Injuries caused by impact with a blunt object where there is no penetration of the skin.	""	0	#FFFFFF
D014950	C26.986	Wounds, Penetrating	Wounds caused by objects penetrating the skin.	""	0	#FFFFFF
D014951	C26.986.950	Wounds, Stab	Penetrating wounds caused by a pointed object.	""	0	#FFFFFF
D014954	C26.088.906	Wrist Injuries	Injuries to the wrist or the wrist joint.	""	0	#FFFFFF
D014972	C15.604.250.410.900|C17.800.973	Xanthogranuloma, Juvenile	Benign disorder of infants and children caused by proliferation of HISTIOCYTES, macrophages found in tissues. These histiocytes, usually lipid-laden non-Langerhans cells, form multiple yellow-red nodules most often in the skin, the eye, and sometimes in the viscera. Patients appear to have normal lipid metabolism and are classified as a normolipemic non-Langerhans cell histiocytosis.	""	0	#FFFFFF
D014973	C18.452.584.750	Xanthomatosis	A condition marked by the development of widespread xanthomas, yellow tumor-like structures filled with lipid deposits. Xanthomas can be found in a variety of tissues including the SKIN; TENDONS; joints of KNEES and ELBOWS. Xanthomatosis is associated with disturbance of LIPID METABOLISM and formation of FOAM CELLS.	""	0	#FFFFFF
D014983	C04.834.867|C16.131.831.936|C16.320.850.970|C17.800.600.925|C17.800.621.936|C17.800.804.936|C17.800.827.970|C18.452.284.975	Xeroderma Pigmentosum	A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.	""	0	#FFFFFF
D014985	C11.187.810|C11.496.260.892	Xerophthalmia	Dryness of the eye surfaces caused by deficiency of tears or conjunctival secretions. It may be associated with vitamin A deficiency, trauma, or any condition in which the eyelids do not close completely.	""	0	#FFFFFF
D014987	C07.465.815.929	Xerostomia	Decreased salivary flow.	""	0	#FFFFFF
D014997	C23.550.210.024.500|C23.550.210.815.970	XYY Karyotype	Abnormal genetic constitution in males characterized by an extra Y chromosome.	""	0	#FFFFFF
D015001	C01.150.252.400.794.840.750|C01.150.252.400.840.750|C01.150.252.819.910|C01.800.720.910|C17.800.838.765.910	Yaws	A systemic non-venereal infection of the tropics caused by TREPONEMA PALLIDUM subspecies pertenue.	""	0	#FFFFFF
D015004	C01.920.500.980|C01.925.081.980|C01.925.782.350.250.980|C01.925.782.417.881	Yellow Fever	An acute infectious disease primarily of the tropics, caused by a virus and transmitted to man by mosquitoes of the genera Aedes and Haemagogus. The severe form is characterized by fever, HEMOLYTIC JAUNDICE, and renal damage.	""	0	#FFFFFF
D015009	C01.150.252.400.310.980	Yersinia Infections	Infections with bacteria of the genus YERSINIA.	""	0	#FFFFFF
D015012	C01.150.252.400.310.980.780	Yersinia pseudotuberculosis Infections	Infections with bacteria of the species YERSINIA PSEUDOTUBERCULOSIS.	""	0	#FFFFFF
D015043	C04.730.713.988|C06.301.371.883|C06.405.249.883|C06.405.469.275.800.924|C06.405.469.965|C06.405.748.586.924|C06.405.748.947	Zollinger-Ellison Syndrome	A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.	""	0	#FFFFFF
D015047	C01.973|C22.969	Zoonoses	Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.	""	0	#FFFFFF
D015051	C10.900.300.284.500.950|C26.404.750.959|C26.915.300.425.500.950	Zygomatic Fractures	Fractures of the zygoma.	""	0	#FFFFFF
D015140	C10.228.140.300.400|C10.228.140.300.510.800.500|C10.228.140.380.230|C10.228.140.695.500|C14.907.137.126.372.500|C14.907.253.560.350.500	Dementia, Vascular	An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)	""	0	#FFFFFF
D015154	C06.405.117.119.500	Esophageal Motility Disorders	Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).	""	0	#FFFFFF
D015155	C06.405.117.119.500.450	Esophageal Spasm, Diffuse	A hypermotility disorder of the ESOPHAGUS that is characterized by spastic non-peristaltic responses to SWALLOWING; CHEST PAIN; and DYSPHAGIA.	""	0	#FFFFFF
D015160	C12.050.703.277.060.480|C15.378.295.480|C15.378.420.826.100.350|C16.300.060.480|C16.320.365.826.100.350|C20.306.480|C23.888.277.395	Hydrops Fetalis	Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.	""	0	#FFFFFF
D015161	C10.228.140.300.150.477.200.199|C10.228.140.300.400.408|C10.228.140.300.775.200.200.199|C10.228.140.380.230.250|C14.907.253.092.477.200.199|C14.907.253.855.200.200.199|C23.550.513.355.250.200.199|C23.550.717.489.250.200.199	Dementia, Multi-Infarct	Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)	""	0	#FFFFFF
D015163	C01.597.880|C01.610.684.880|C01.925.597.880	Superinfection	A frequent complication of drug therapy for microbial infection. It may result from opportunistic colonization following immunosuppression by the primary pathogen and can be influenced by the time interval between infections, microbial physiology, or host resistance. Experimental challenge and in vitro models are sometimes used in virulence and infectivity studies.	""	0	#FFFFFF
D015168	C26.324.550	Lightning Injuries	Accidental injuries caused by brief high-voltage electrical discharges during thunderstorms. Cardiopulmonary arrest, coma and other neurologic symptoms, myocardial necrosis, and dermal burns are common. Prompt treatment of the acute sequelae, including cardiopulmonary resuscitation, is indicated for survival.	""	0	#FFFFFF
D015173	C04.588.614.250.195.885|C10.228.140.211.885|C10.551.240.250.700	Supratentorial Neoplasms	Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.	""	0	#FFFFFF
D015174	C04.588.614.250.803.342|C10.228.854.765.342|C10.551.240.750.200	Epidural Neoplasms	Neoplasms located in the space between the vertebral PERIOSTEUM and DURA MATER surrounding the SPINAL CORD. Tumors in this location are most often metastatic in origin and may cause neurologic deficits by mass effect on the spinal cord or nerve roots or by interfering with blood supply to the spinal cord.	""	0	#FFFFFF
D015175	C04.557.470.035.625|C04.588.322.609.792|C10.228.140.617.738.675.800|C19.344.609.792|C19.700.734.792	Prolactinoma	A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.	""	0	#FFFFFF
D015179	C04.588.274.476.411.307|C06.301.371.411.307|C06.405.249.411.307|C06.405.469.158.356|C06.405.469.491.307|C06.405.469.860.180	Colorectal Neoplasms	Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	""	0	#FFFFFF
D015192	C04.588.614.250.195.411|C10.228.140.211.500|C10.551.240.250.400	Infratentorial Neoplasms	Intracranial tumors originating in the region of the brain inferior to the TENTORIUM CEREBELLI, which contains the cerebellum, FOURTH VENTRICLE; CEREBELLOPONTINE ANGLE; BRAIN STEM, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).	""	0	#FFFFFF
D015207	C05.550.114.606.400|C05.799.613.400	Osteoarthritis, Hip	Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.	""	0	#FFFFFF
D015208	C26.200.322.800	Smoke Inhalation Injury	Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.	""	0	#FFFFFF
D015209	C06.130.120.200.110	Cholangitis, Sclerosing	Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.	""	0	#FFFFFF
D015210	C05.550.114.423.410|C05.550.354.500.500|C05.799.414.410|C16.320.565.798.368.410|C18.452.648.798.368.410	Arthritis, Gouty	Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular. Acute and chronic gouty arthritis are associated with accumulation of MONOSODIUM URATE in and around affected joints.	""	0	#FFFFFF
D015211	C06.552.970|C10.228.140.163.100.968|C12.050.351.968.419.978|C12.200.777.419.978|C12.950.419.978|C16.131.077.970|C16.320.565.189.968|C16.320.565.663.970|C18.452.132.100.968|C18.452.648.189.968|C18.452.648.663.970	Zellweger Syndrome	An autosomal recessive disorder due to defects in PEROXISOME biogenesis which involves more than 13 genes encoding peroxin proteins of the peroxisomal membrane and matrix. Zellweger syndrome is typically seen in the neonatal period with features such as dysmorphic skull; MUSCLE HYPOTONIA; SENSORINEURAL HEARING LOSS; visual compromise; SEIZURES; progressive degeneration of the KIDNEYS and the LIVER. Zellweger-like syndrome refers to phenotypes resembling the neonatal Zellweger syndrome but seen in children or adults with apparently intact peroxisome biogenesis.	""	0	#FFFFFF
D015212	C06.405.205.731|C06.405.469.432	Inflammatory Bowel Diseases	Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.	""	0	#FFFFFF
D015217	C16.320.565.398.641.201|C16.320.565.595.201|C18.452.584.563.641.201|C18.452.648.398.641.201|C18.452.648.595.201	Cholesterol Ester Storage Disease	An autosomal recessive disorder caused by mutations in the gene for acid lipase (STEROL ESTERASE). It is characterized by the accumulation of neutral lipids, particularly CHOLESTEROL ESTERS in leukocytes, fibroblasts, and hepatocytes.	""	0	#FFFFFF
D015218	C05.116.540.600|C05.799.440|C17.300.775.440	Hyperostosis, Sternocostoclavicular	A rare, benign rheumatologic disorder or syndrome characterized by hyperostosis and soft tissue ossification between the clavicles and the anterior part of the upper ribs. It is often associated with the dermatologic disorder palmoplantar pustulosis, particularly in Japan. Careful diagnosis is required to distinguish it from psoriatic arthritis, OSTEITIS DEFORMANS, and other diseases. Spondylitis of pustulosis palmaris et plantaris is one of the possible causes; also, evidence suggests one origin may be bone infection. Bone imaging is especially useful for diagnosis. It was originally described by Sonozaki in 1974.	""	0	#FFFFFF
D015223	C16.320.565.398.641.201.500|C16.320.565.595.201.500|C16.614.947|C18.452.584.563.641.201.500|C18.452.648.398.641.201.500|C18.452.648.595.201.500	Wolman Disease	The severe infantile form of inherited lysosomal lipid storage diseases due to deficiency of acid lipase (STEROL ESTERASE). It is characterized by the accumulation of neutral lipids, particularly CHOLESTEROL ESTERS in leukocytes, fibroblasts, and hepatocytes. It is also known as Wolman's xanthomatosis and is an allelic variant of CHOLESTEROL ESTER STORAGE DISEASE.	""	0	#FFFFFF
D015228	C18.452.584.500.500.851	Hypertriglyceridemia	A condition of elevated levels of TRIGLYCERIDES in the blood.	""	0	#FFFFFF
D015229	C01.221.812.640|C01.778.640|C01.925.813|C12.100.937.640|C23.550.291.531.937.640	Sexually Transmitted Diseases, Viral	Viral diseases which are transmitted or propagated by sexual conduct.	""	0	#FFFFFF
D015231	C01.150.252.734|C01.221.812.281|C01.778.281|C12.100.937.281|C23.550.291.531.937.281	Sexually Transmitted Diseases, Bacterial	Bacterial diseases transmitted or propagated by sexual conduct.	""	0	#FFFFFF
D015266	C01.925.256.721.150|C01.925.928.216|C04.557.465.625.650.240.325|C04.557.470.200.025.370.325|C04.557.580.625.650.240.325	Carcinoma, Merkel Cell	A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)	""	0	#FFFFFF
D015267	C14.907.940.897.249.249|C15.604.515.292.015|C20.111.193.500	Churg-Strauss Syndrome	Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.	""	0	#FFFFFF
D015270	C01.150.252.410.040.552.475.495	Mycobacterium avium-intracellulare Infection	A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.	""	0	#FFFFFF
D015275	C15.604.515.880|C20.683.515.950	Tumor Lysis Syndrome	A syndrome resulting from cytotoxic therapy, occurring generally in aggressive, rapidly proliferating lymphoproliferative disorders. It is characterized by combinations of hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia.	""	0	#FFFFFF
D015299	C01.160.762.301|C05.116.165.762.301|C05.116.900.853.500	Discitis	Inflammation of an INTERVERTEBRAL DISC or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.	""	0	#FFFFFF
D015318	C16.320.565.202.251|C18.452.648.202.251	Fructose Metabolism, Inborn Errors	Inherited abnormalities of fructose metabolism, which include three known autosomal recessive types: hepatic fructokinase deficiency (essential fructosuria), hereditary fructose intolerance, and hereditary fructose-1,6-diphosphatase deficiency. Essential fructosuria is a benign asymptomatic metabolic disorder caused by deficiency in fructokinase, leading to decreased conversion of fructose to fructose-1-phosphate and alimentary hyperfructosemia, but with no clinical dysfunction; may produce a false-positive diabetes test.	""	0	#FFFFFF
D015319	C16.320.565.202.251.221|C18.452.648.202.251.221	Fructose-1,6-Diphosphatase Deficiency	An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.	""	0	#FFFFFF
D015323	C16.320.565.202.810|C18.452.648.202.810	Pyruvate Metabolism, Inborn Errors	Hereditary disorders of pyruvate metabolism. They are difficult to diagnose and describe because pyruvate is a key intermediate in glycolysis, gluconeogenesis, and the tricarboxylic acid cycle. Some inherited metabolic disorders may alter pyruvate metabolism indirectly. Disorders in pyruvate metabolism appear to lead to deficiencies in neurotransmitter synthesis and, consequently, to nervous system disorders.	""	0	#FFFFFF
D015324	C10.228.140.163.100.725|C16.320.565.189.725|C16.320.565.202.810.666|C18.452.132.100.725|C18.452.648.189.725|C18.452.648.202.810.666|C18.452.660.705	Pyruvate Carboxylase Deficiency Disease	An autosomal recessive metabolic disorder caused by absent or decreased PYRUVATE CARBOXYLASE activity, the enzyme that regulates gluconeogenesis, lipogenesis, and neurotransmitter synthesis. Clinical manifestations include lactic acidosis, seizures, respiratory distress, marked psychomotor delay, periodic HYPOGLYCEMIA, and hypotonia. The clinical course may be similar to LEIGH DISEASE. (From Am J Hum Genet 1998 Jun;62(6):1312-9)	""	0	#FFFFFF
D015325	C10.228.140.163.100.750|C10.597.606.360.455.875|C16.320.322.500.875|C16.320.400.525.875|C16.320.565.189.750|C16.320.565.202.810.766|C18.452.132.100.750|C18.452.648.189.750|C18.452.648.202.810.766|C18.452.660.710	Pyruvate Dehydrogenase Complex Deficiency Disease	An inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the complex leads to LEIGH DISEASE.	""	0	#FFFFFF
D015352	C11.496.260	Dry Eye Syndromes	Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.	""	0	#FFFFFF
D015354	C10.597.751.941.905|C11.966.905|C23.888.592.763.941.848	Vision, Low	Vision considered to be inferior to normal vision as represented by accepted standards of acuity, field of vision, or motility. Low vision generally refers to visual disorders that are caused by diseases that cannot be corrected by refraction (e.g., MACULAR DEGENERATION; RETINITIS PIGMENTOSA; DIABETIC RETINOPATHY, etc.).	""	0	#FFFFFF
D015355	C11.525.381.348	Glaucoma, Neovascular	A form of secondary glaucoma which develops as a consequence of another ocular disease and is attributed to the forming of new vessels in the angle of the anterior chamber.	""	0	#FFFFFF
D015356	C11.768.400|C14.907.137.780	Retinal Artery Occlusion	Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.	""	0	#FFFFFF
D015362	C18.654.180	Child Nutrition Disorders	Disorders caused by nutritional imbalance, either overnutrition or undernutrition, occurring in children ages 2 to 12 years.	""	0	#FFFFFF
D015408	C04.557.470.200.025.290.500|C04.588.274.761.500.124|C04.588.322.475.500.124|C06.301.761.500.124|C06.689.667.500.124|C19.344.421.500.124	Gastrinoma	A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).	""	0	#FFFFFF
D015417	C10.500.300|C10.574.500.495|C10.668.829.800.300|C16.131.666.300|C16.320.400.375	Hereditary Sensory and Motor Neuropathy	A group of slowly progressive inherited disorders affecting motor and sensory peripheral nerves. Subtypes include HMSNs I-VII. HMSN I and II both refer to CHARCOT-MARIE-TOOTH DISEASE. HMSN III refers to hypertrophic neuropathy of infancy. HMSN IV refers to REFSUM DISEASE. HMSN V refers to a condition marked by a hereditary motor and sensory neuropathy associated with spastic paraplegia (see SPASTIC PARAPLEGIA, HEREDITARY). HMSN VI refers to HMSN associated with an inherited optic atrophy (OPTIC ATROPHIES, HEREDITARY), and HMSN VII refers to HMSN associated with retinitis pigmentosa. (From Adams et al., Principles of Neurology, 6th ed, p1343)	""	0	#FFFFFF
D015418	C10.292.700.225.500|C10.574.500.662|C11.270.564|C11.640.451.451|C16.320.290.564|C16.320.400.630	Optic Atrophies, Hereditary	Hereditary conditions that feature progressive visual loss in association with optic atrophy. Relatively common forms include autosomal dominant optic atrophy (OPTIC ATROPHY, AUTOSOMAL DOMINANT) and Leber hereditary optic atrophy (OPTIC ATROPHY, HEREDITARY, LEBER).	""	0	#FFFFFF
D015419	C10.500.300.820|C10.574.500.495.820|C10.668.829.800.300.820|C16.131.666.300.820|C16.320.400.375.820	Spastic Paraplegia, Hereditary	A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)	""	0	#FFFFFF
D015422	C11.790	Scleral Diseases	General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.	""	0	#FFFFFF
D015423	C11.790.500	Scleritis	Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.	""	0	#FFFFFF
D015427	C14.907.725|C23.550.767.877	Reperfusion Injury	Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	""	0	#FFFFFF
D015428	C14.280.238.615|C14.280.647.625|C14.907.585.625|C14.907.725.600|C23.550.767.877.500	Myocardial Reperfusion Injury	Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.	""	0	#FFFFFF
D015430	C23.888.144.243.926	Weight Gain	Increase in BODY WEIGHT over existing weight.	""	0	#FFFFFF
D015431	C23.888.144.243.963	Weight Loss	Decrease in existing BODY WEIGHT.	""	0	#FFFFFF
D015432	C12.050.351.968.419.570.363.615|C12.200.777.419.570.363.615|C12.950.419.570.363.615|C20.425	Glomerulonephritis, Membranoproliferative	Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.	""	0	#FFFFFF
D015433	C12.050.351.968.419.570.363.625|C12.200.777.419.570.363.625|C12.950.419.570.363.625|C20.111.535	Glomerulonephritis, Membranous	A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.	""	0	#FFFFFF
D015434	C17.300.710|C17.800.566	Panniculitis	General term for inflammation of adipose tissue, usually of the skin, characterized by reddened subcutaneous nodules.	""	0	#FFFFFF
D015435	C17.300.475.479.400|C17.300.710.400|C17.800.480.479.400|C17.800.566.400	Panniculitis, Lupus Erythematosus	A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.	""	0	#FFFFFF
D015436	C06.844.600|C17.300.710.600	Panniculitis, Peritoneal	INFLAMMATION of the underlying layer of ADIPOSE TISSUE (panniculus) of the PERITONEUM, usually of the MESENTERY or the OMENTUM. There are several forms with various names and are usually characterized by infiltration of LYMPHOCYTES and NEUTROPHILS, fat NECROSIS, and FIBROSIS.	""	0	#FFFFFF
D015439	C01.150.252.410.040.552.475.371.850.249	Leprosy, Borderline	A form of LEPROSY in which there are clinical manifestations of both principal types (lepromatous and tuberculoid). The disease may shift toward one of these two polar or principal forms.	""	0	#FFFFFF
D015440	C01.150.252.410.040.552.475.371.775.500	Leprosy, Lepromatous	A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.	""	0	#FFFFFF
D015441	C01.150.252.410.040.552.475.371.850.500	Leprosy, Tuberculoid	A principal or polar form of LEPROSY in which the skin lesions are few and are sharply demarcated. Peripheral nerve involvement is pronounced and may be severe. Unlike lepromatous leprosy (LEPROSY, LEPROMATOUS), the lepromin test is positive. Tuberculoid leprosy is rarely a source of infection to others.	""	0	#FFFFFF
D015448	C04.557.337.428.080|C15.604.515.560.080|C20.683.515.528.080	Leukemia, B-Cell	A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.	""	0	#FFFFFF
D015451	C04.557.337.428.080.125|C15.604.515.560.080.125|C20.683.515.528.080.125|C23.550.291.500.483	Leukemia, Lymphocytic, Chronic, B-Cell	A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.	""	0	#FFFFFF
D015452	C04.557.337.428.600.600|C15.604.515.560.600.600|C20.683.515.528.600.600	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.	""	0	#FFFFFF
D015456	C04.557.337.428.100|C15.604.515.560.100|C20.683.515.528.100	Leukemia, Biphenotypic, Acute	An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS.	""	0	#FFFFFF
D015458	C04.557.337.428.580|C15.604.515.560.575|C20.683.515.528.582	Leukemia, T-Cell	A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.	""	0	#FFFFFF
D015459	C04.557.337.428.580.100|C15.604.515.560.575.100|C20.683.515.528.582.100	Leukemia-Lymphoma, Adult T-Cell	Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.	""	0	#FFFFFF
D015461	C04.557.337.428.565.750|C04.557.337.428.580.075|C15.604.515.560.550.750|C15.604.515.560.575.125|C20.683.515.528.565.750|C20.683.515.528.582.125	Leukemia, Prolymphocytic, T-Cell	A lymphoid leukemia characterized by a profound LYMPHOCYTOSIS with or without LYMPHADENOPATHY, hepatosplenomegaly, frequently rapid progression, and short survival. It was formerly called T-cell chronic lymphocytic leukemia.	""	0	#FFFFFF
D015463	C04.557.337.428.565|C15.604.515.560.550|C20.683.515.528.565	Leukemia, Prolymphocytic	A chronic leukemia characterized by a large number of circulating prolymphocytes. It can arise spontaneously or as a consequence of transformation of CHRONIC LYMPHOCYTIC LEUKEMIA.	""	0	#FFFFFF
D015464	C04.557.337.539.250|C15.378.190.636.370|C23.550.291.500.485	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.	""	0	#FFFFFF
D015465	C04.557.337.539.250.300|C15.378.190.636.370.300|C23.550.291.500.485.300	Leukemia, Myeloid, Accelerated Phase	The phase of chronic myeloid leukemia following the chronic phase (LEUKEMIA, MYELOID, CHRONIC-PHASE), where there are increased systemic symptoms, worsening cytopenias, and refractory LEUKOCYTOSIS.	""	0	#FFFFFF
D015466	C04.557.337.539.250.400|C15.378.190.636.370.400|C23.550.291.500.485.400	Leukemia, Myeloid, Chronic-Phase	The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.	""	0	#FFFFFF
D015467	C15.378.190.636.380|C23.550.291.500.497	Leukemia, Neutrophilic, Chronic	A rare myeloproliferative disorder that is characterized by a sustained, mature neutrophilic leukocytosis. No monocytosis, EOSINOPHILIA, or basophilia is present, nor is there a PHILADELPHIA CHROMOSOME or bcr-abl fusion gene (GENES, ABL).	""	0	#FFFFFF
D015470	C04.557.337.539.275	Leukemia, Myeloid, Acute	Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	""	0	#FFFFFF
D015471	C04.557.337.539.275.125	Leukemia, Basophilic, Acute	A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.	""	0	#FFFFFF
D015472	C04.557.337.539.275.300	Leukemia, Eosinophilic, Acute	A rare acute myeloid leukemia characterized by abnormal EOSINOPHILS in the bone marrow.	""	0	#FFFFFF
D015473	C04.557.337.539.275.700	Leukemia, Promyelocytic, Acute	An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.	""	0	#FFFFFF
D015477	C04.557.337.539.522|C15.378.190.615.510|C23.550.291.500.495	Leukemia, Myelomonocytic, Chronic	A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.	""	0	#FFFFFF
D015479	C04.557.337.539.520	Leukemia, Myelomonocytic, Acute	A pediatric acute myeloid leukemia involving both myeloid and monocytoid precursors. At least 20% of non-erythroid cells are of monocytic origin.	""	0	#FFFFFF
D015490	C01.925.782.815.200.470|C20.673.483.470	HTLV-I Infections	Diseases caused by HUMAN T-LYMPHOTROPIC VIRUS 1.	""	0	#FFFFFF
D015491	C01.925.782.815.200.480|C20.673.483.480	HTLV-II Infections	Diseases caused by HUMAN T-LYMPHOTROPIC VIRUS 2.	""	0	#FFFFFF
D015493	C01.207.618.500|C01.925.782.815.200.470.710|C10.228.228.618.500|C10.228.854.525.700|C10.586.750.700	Paraparesis, Tropical Spastic	A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)	""	0	#FFFFFF
D015494	C07.465.815.497.500|C23.300.175.700.500	Salivary Gland Calculi	Calculi occurring in a salivary gland. Most salivary gland calculi occur in the submandibular gland, but can also occur in the parotid gland and in the sublingual and minor salivary glands.	""	0	#FFFFFF
D015499	C12.050.351.968.419.815|C12.200.777.419.815|C12.950.419.815|C16.320.565.893|C16.320.831|C18.452.648.893	Renal Tubular Transport, Inborn Errors	Genetic defects in the selective or non-selective transport functions of the KIDNEY TUBULES.	""	0	#FFFFFF
D015508	C08.460.525|C08.618.846.185.525|C09.603.525	Nasal Obstruction	Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.	""	0	#FFFFFF
D015511	C22.405	Goat Diseases	Diseases of the domestic or wild goat of the genus Capra.	""	0	#FFFFFF
D015518	C10.597.606.360.455.937|C16.320.322.500.937|C16.320.400.525.937	Rett Syndrome	An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)	""	0	#FFFFFF
D015521	C01.748.749.267|C08.460.692.752.267|C08.730.749.267|C09.603.692.752.267	Ethmoid Sinusitis	Inflammation of the NASAL MUCOSA in the ETHMOID SINUS. It may present itself as an acute (infectious) or chronic (allergic) condition.	""	0	#FFFFFF
D015522	C01.748.749.387|C08.460.692.752.387|C08.730.749.387|C09.603.692.752.387	Frontal Sinusitis	Inflammation of the NASAL MUCOSA in the FRONTAL SINUS. In many cases, it is caused by an infection of the bacteria STREPTOCOCCUS PNEUMONIAE or HAEMOPHILUS INFLUENZAE.	""	0	#FFFFFF
D015523	C01.748.749.578|C08.460.692.752.578|C08.730.749.578|C09.603.692.752.578	Maxillary Sinusitis	Inflammation of the NASAL MUCOSA in the MAXILLARY SINUS. In many cases, it is caused by an infection of the bacteria HAEMOPHILUS INFLUENZAE; STREPTOCOCCUS PNEUMONIAE; or STAPHYLOCOCCUS AUREUS.	""	0	#FFFFFF
D015524	C01.748.749.827|C08.460.692.752.827|C08.730.749.827|C09.603.692.752.827	Sphenoid Sinusitis	Inflammation of the NASAL MUCOSA in the SPHENOID SINUS. Isolated sphenoid sinusitis is uncommon. It usually occurs in conjunction with other paranasal sinusitis.	""	0	#FFFFFF
D015526	C01.221.250.875.049|C01.221.812.640.400.070|C01.778.640.400.070|C01.925.782.815.616.400.049|C01.925.813.400.070|C10.228.140.380.070|C12.100.937.640.400.070|C20.673.480.070	AIDS Dementia Complex	A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)	""	0	#FFFFFF
D015529	C04.182.198|C06.130.120.127|C06.198.184|C16.131.314.184	Choledochal Cyst	A congenital anatomic malformation of a bile duct, including cystic dilatation of the extrahepatic bile duct or the large intrahepatic bile duct. Classification is based on the site and type of dilatation. Type I is most common.	""	0	#FFFFFF
D015535	C05.116.900.853.625.800.424|C05.550.114.145|C05.550.114.865.800.424|C17.800.859.675.175	Arthritis, Psoriatic	A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.	""	0	#FFFFFF
D015576	C05.116.540	Hyperostosis	Increase in the mass of bone per unit volume.	""	0	#FFFFFF
D015593	C11.768.585.585	Retinal Drusen	Colloid or hyaline bodies lying beneath the retinal pigment epithelium. They may occur either secondary to changes in the choroid that affect the pigment epithelium or as an autosomal dominant disorder of the retinal pigment epithelium.	""	0	#FFFFFF
D015594	C10.292.700.450|C11.640.513	Optic Disk Drusen	Optic disk bodies composed primarily of acid mucopolysaccharides that may produce pseudopapilledema (elevation of the optic disk without associated INTRACRANIAL HYPERTENSION) and visual field deficits. Drusen may also occur in the retina (see RETINAL DRUSEN). (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p355)	""	0	#FFFFFF
D015597	C01.610.718|C12.050.703.700.680	Pregnancy Complications, Parasitic	The co-occurrence of pregnancy and parasitic diseases. The parasitic infection may precede or follow FERTILIZATION.	""	0	#FFFFFF
D015605	C01.925.256.743.175	Cowpox	A mild, eruptive skin disease of milk cows caused by COWPOX VIRUS, with lesions occurring principally on the udder and teats. Human infection may occur while milking an infected animal.	""	0	#FFFFFF
D015614	C15.604.250	Histiocytosis	General term for the abnormal appearance of histiocytes in the blood. Based on the pathological features of the cells involved rather than on clinical findings, the histiocytic diseases are subdivided into three groups: HISTIOCYTOSIS, LANGERHANS CELL; HISTIOCYTOSIS, NON-LANGERHANS-CELL; and HISTIOCYTIC DISORDERS, MALIGNANT.	""	0	#FFFFFF
D015615	C08.381.150|C08.695.290|C16.131.740.290	Cystic Adenomatoid Malformation of Lung, Congenital	An abnormality in lung development that is characterized by a multicystic mass resulting from an adenomatous overgrowth of the terminal BRONCHIOLES with a consequent reduction of PULMONARY ALVEOLI. This anomaly is classified into three types by the cyst size.	""	0	#FFFFFF
D015616	C15.604.250.410	Histiocytosis, Non-Langerhans-Cell	Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; JUVENILE XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES).	""	0	#FFFFFF
D015618	C15.604.250.410.450	Histiocytosis, Sinus	Benign, non-Langerhans-cell, histiocytic proliferative disorder that primarily affects the lymph nodes. It is often referred to as sinus histiocytosis with massive lymphadenopathy.	""	0	#FFFFFF
D015619	C08.695|C16.131.740	Respiratory System Abnormalities	Congenital structural abnormalities of the respiratory system.	""	0	#FFFFFF
D015620	C04.557.227|C15.604.250.390	Histiocytic Disorders, Malignant	Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.	""	0	#FFFFFF
D015624	C04.588.614.550.500.225|C04.730.856.490.225|C10.114.656.150|C10.574.781.588.225|C10.668.758.725.150|C20.111.258.500.150	Lambert-Eaton Myasthenic Syndrome	An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)	""	0	#FFFFFF
D015651	C25.723.680	Mycotoxicosis	Poisoning caused by the ingestion of mycotoxins (toxins of fungal origin).	""	0	#FFFFFF
D015658	C01.221.250.875|C01.221.812.640.400|C01.778.640.400|C01.925.782.815.616.400|C01.925.813.400|C12.100.937.640.400|C20.673.480	HIV Infections	Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	""	0	#FFFFFF
D015663	C05.116.198.579.610|C18.452.104.579.610	Osteoporosis, Postmenopausal	Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.	""	0	#FFFFFF
D015673	C01.925.330|C05.651.310|C10.586.500.600|C10.668.364|C23.550.291.500.407	Fatigue Syndrome, Chronic	A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)	""	0	#FFFFFF
D015674	C04.588.531|C22.520	Mammary Neoplasms, Animal	Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).	""	0	#FFFFFF
D015701	C26.304.500	Near Drowning	Non-fatal immersion or submersion in water. The subject is resuscitable.	""	0	#FFFFFF
D015715	C11.204.267	Corneal Edema	An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.	""	0	#FFFFFF
D015745	C23.550.382.437|C26.392.560.325	Granuloma, Foreign-Body	Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.	""	0	#FFFFFF
D015746	C23.888.592.612.054|C23.888.821.030	Abdominal Pain	Sensation of discomfort, distress, or agony in the abdominal region.	""	0	#FFFFFF
D015769	C08.280|C23.550.382.968	Granuloma, Respiratory Tract	Granulomatous disorders affecting one or more sites in the respiratory tract.	""	0	#FFFFFF
D015775	C26.404.437	Fractures, Stress	Fractures due to the strain caused by repetitive exercise. They are thought to arise from a combination of MUSCLE FATIGUE and bone failure, and occur in situations where BONE REMODELING predominates over repair. The most common sites of stress fractures are the METATARSUS; FIBULA; TIBIA; and FEMORAL NECK.	""	0	#FFFFFF
D015776	C16.320.850.475.440|C17.800.428.435.440|C17.800.827.475.440	Keratoderma, Palmoplantar, Diffuse	An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.	""	0	#FFFFFF
D015783	C11.250.060|C11.270.060|C11.941.375.060|C16.131.384.079|C16.320.290.078	Aniridia	A congenital abnormality in which there is only a rudimentary iris. This is due to the failure of the optic cup to grow. Aniridia also occurs in a hereditary form, usually autosomal dominant.	""	0	#FFFFFF
D015785	C11.270|C16.320.290	Eye Diseases, Hereditary	Transmission of gene defects or chromosomal aberrations/abnormalities which are expressed in extreme variation in the structure or function of the eye. These may be evident at birth, but may be manifested later with progression of the disorder.	""	0	#FFFFFF
D015787	C01.150.252.400.536.400|C01.150.252.400.794.352.250.400|C01.150.252.819.310|C01.800.720.310|C01.920.930.513.400|C17.800.229.200|C17.800.838.765.310	Erythema Chronicum Migrans	A deep type of gyrate erythema that follows a bite by an ixodid tick; it is a stage-1 manifestation of LYME DISEASE. The site of the bite is characterized by a red papule that expands peripherally as a nonscaling, palpable band that clears centrally. This condition is often associated with systemic symptoms such as chills, fever, headache, malaise, nausea, vomiting, fatigue, backache, and stiff neck.	""	0	#FFFFFF
D015792	C11.250.666|C11.270.660|C11.768.660|C16.131.384.784|C16.320.290.660	Retinal Dysplasia	Congenital, often bilateral, retinal abnormality characterized by the arrangement of outer nuclear retinal cells in a palisading or radiating pattern surrounding a central ocular space. This disorder is sometimes hereditary.	""	0	#FFFFFF
D015794	C11.270.142|C11.941.160.300|C16.320.290.142|C16.320.322.092	Choroideremia	An X chromosome-linked abnormality characterized by atrophy of the choroid and degeneration of the retinal pigment epithelium causing night blindness.	""	0	#FFFFFF
D015799	C11.270.468|C11.941.160.578|C16.320.290.468	Gyrate Atrophy	Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.	""	0	#FFFFFF
D015807	C10.900.300.284.250.270|C26.915.300.425.250.270|C26.986.450	Eye Injuries, Penetrating	Deeply perforating or puncturing type intraocular injuries.	""	0	#FFFFFF
D015811	C04.588.364.978.400|C11.319.494.400|C11.941.375.375|C11.941.855.400	Iris Neoplasms	Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.	""	0	#FFFFFF
D015812	C11.525.381.056	Glaucoma, Angle-Closure	A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber.	""	0	#FFFFFF
D015814	C11.540	Ocular Hypotension	Abnormally low intraocular pressure often related to chronic inflammation (uveitis).	""	0	#FFFFFF
D015817	C01.375|C11.294	Eye Infections	Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.	""	0	#FFFFFF
D015818	C01.150.252.289|C01.375.354|C11.294.354	Eye Infections, Bacterial	Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.	""	0	#FFFFFF
D015819	C25.775.793	Substance Abuse, Intravenous	Abuse, overuse, or misuse of a substance by its injection into a vein.	""	0	#FFFFFF
D015821	C01.150.703.320|C01.375.450|C11.294.450	Eye Infections, Fungal	Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.	""	0	#FFFFFF
D015822	C01.610.300|C11.294.725	Eye Infections, Parasitic	Mild to severe infections of the eye and its adjacent structures (adnexa) by adult or larval protozoan or metazoan parasites.	""	0	#FFFFFF
D015823	C01.610.300.125|C01.610.752.049.203|C11.204.564.112|C11.294.725.125	Acanthamoeba Keratitis	Infection of the cornea by an ameboid protozoan which may cause corneal ulceration leading to blindness.	""	0	#FFFFFF
D015826	C05.116.099.708.582	Langer-Giedion Syndrome	Autosomal dominant disorder characterized by cone-shaped epiphyses in the hands and multiple cartilaginous exostoses. INTELLECTUAL DISABILITY and abnormalities of chromosome 8 are often present. The exostoses in this syndrome appear identical to those of hereditary multiple exostoses (EXOSTOSES, HEREDITARY MULTIPLE).	""	0	#FFFFFF
D015827	C01.610.300.562|C01.610.335.508.700.750.361.699.500|C01.920.891|C11.294.725.562	Onchocerciasis, Ocular	Filarial infection of the eyes transmitted from person to person by bites of Onchocerca volvulus-infected black flies. The microfilariae of Onchocerca are thus deposited beneath the skin. They migrate through various tissues including the eye. Those persons infected have impaired vision and up to 20% are blind. The incidence of eye lesions has been reported to be as high as 30% in Central America and parts of Africa.	""	0	#FFFFFF
D015828	C01.375.725|C01.925.325|C11.294.800	Eye Infections, Viral	Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.	""	0	#FFFFFF
D015829	C01.150.252.289.900|C01.150.703.320.900|C01.375.265.500|C01.375.354.900|C01.375.450.900|C01.830.900|C11.294.265.500|C11.294.354.900|C11.294.450.900|C11.941.879.960	Uveitis, Suppurative	Intraocular infection caused mainly by pus-producing bacteria and rarely by fungi. The infection may be caused by an injury or surgical wound (exogenous) or by endogenous septic emboli in such diseases as bacterial endocarditis or meningococcemia.	""	0	#FFFFFF
D015831	C04.557.450.565.575.610|C05.116.099.708.670	Osteochondroma	A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.	""	0	#FFFFFF
D015834	C09.218.568.120	Cochlear Diseases	Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).	""	0	#FFFFFF
D015835	C10.228.758|C10.292.562|C11.590	Ocular Motility Disorders	Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)	""	0	#FFFFFF
D015837	C09.218.568.900	Vestibular Diseases	Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.	""	0	#FFFFFF
D015838	C05.550.287	Chondromatosis, Synovial	Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.	""	0	#FFFFFF
D015840	C10.292.562.700|C11.590.436	Oculomotor Nerve Diseases	Diseases of the oculomotor nerve or nucleus that result in weakness or paralysis of the superior rectus, inferior rectus, medial rectus, inferior oblique, or levator palpebrae muscles, or impaired parasympathetic innervation to the pupil. With a complete oculomotor palsy, the eyelid will be paralyzed, the eye will be in an abducted and inferior position, and the pupil will be markedly dilated. Commonly associated conditions include neoplasms, CRANIOCEREBRAL TRAUMA, ischemia (especially in association with DIABETES MELLITUS), and aneurysmal compression. (From Adams et al., Principles of Neurology, 6th ed, p270)	""	0	#FFFFFF
D015841	C11.675.319	Enophthalmos	Recession of the eyeball into the orbit.	""	0	#FFFFFF
D015845	C10.597.690.575|C11.710.800|C23.888.592.708.575	Tonic Pupil	"A pupillary abnormality characterized by a poor pupillary light reaction, reduced accommodation, iris sector palsies, an enhanced pupillary response to near effort that results in a prolonged, ""tonic"" constriction, and slow pupillary redilation. This condition is associated with injury to the postganglionic parasympathetic innervation to the pupil. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp492-500)"	""	0	#FFFFFF
D015858	C11.744.126	Anisometropia	A condition of an inequality of refractive power of the two eyes.	""	0	#FFFFFF
D015861	C11.768.725|C23.550.589.500.725	Retinal Neovascularization	Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.	""	0	#FFFFFF
D015862	C11.941.160	Choroid Diseases	Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.	""	0	#FFFFFF
D015863	C11.941.375.360|C11.941.879.780.880.400	Iridocyclitis	Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of the iris, and constricted, sluggish pupil. Symptoms include radiating pain, photophobia, lacrimation, and interference with vision.	""	0	#FFFFFF
D015864	C11.941.879.780	Panuveitis	Inflammation in which both the anterior and posterior segments of the uvea are involved and a specific focus is not apparent. It is often severe and extensive and a serious threat to vision. Causes include systemic diseases such as tuberculosis, sarcoidosis, and syphilis, as well as malignancies. The intermediate segment of the eye is not involved.	""	0	#FFFFFF
D015866	C11.941.879.780.900	Uveitis, Posterior	Inflammation of the choroid as well as the retina and vitreous body. Some form of visual disturbance is usually present. The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis.	""	0	#FFFFFF
D015867	C11.941.879.900	Uveitis, Intermediate	Inflammation of the pars plana, ciliary body, and adjacent structures.	""	0	#FFFFFF
D015868	C11.941.160.478.700|C11.941.879.780.900.300.659|C11.941.879.900.500	Pars Planitis	Form of granulomatous uveitis occurring in the region of the pars plana. This disorder is a common condition with no detectable focal pathology. It causes fibrovascular proliferation at the inferior ora serrata.	""	0	#FFFFFF
D015875	C10.597.690.150|C11.710.090|C23.888.592.708.150	Anisocoria	Unequal pupil size, which may represent a benign physiologic variant or a manifestation of disease. Pathologic anisocoria reflects an abnormality in the musculature of the iris (IRIS DISEASES) or in the parasympathetic or sympathetic pathways that innervate the pupil. Physiologic anisocoria refers to an asymmetry of pupil diameter, usually less than 2mm, that is not associated with disease.	""	0	#FFFFFF
D015877	C10.597.690.362|C11.710.528|C23.888.592.708.362	Miosis	Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.	""	0	#FFFFFF
D015878	C11.710.570	Mydriasis	Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.	""	0	#FFFFFF
D015882	C11.768.773.674	Retinal Necrosis Syndrome, Acute	Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome.	""	0	#FFFFFF
D016055	C12.050.351.968.934.880|C12.200.777.934.880|C12.950.934.880	Urinary Retention	Inability to empty the URINARY BLADDER with voiding (URINATION).	""	0	#FFFFFF
D016063	C23.550.414.300|C23.550.505.300	Blood Loss, Surgical	Loss of blood during a surgical procedure.	""	0	#FFFFFF
D016066	C04.588.894.797.640.700|C08.528.652.700|C08.528.694.700|C08.785.640.700	Pleural Effusion, Malignant	Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.	""	0	#FFFFFF
D016080	C04.182.044|C04.588.614.250.387.100|C10.500.142.100|C10.551.240.375.100|C16.131.666.142.100	Arachnoid Cysts	Intracranial or spinal cavities containing a cerebrospinal-like fluid, the wall of which is composed of arachnoidal cells. They are most often developmental or related to trauma. Intracranial arachnoid cysts usually occur adjacent to arachnoidal cistern and may present with HYDROCEPHALUS; HEADACHE; SEIZURES; and focal neurologic signs. (From Joynt, Clinical Neurology, 1994, Ch44, pp105-115)	""	0	#FFFFFF
D016097	C01.925.782.815.616.850|C01.925.839.850|C22.735.500.850	Simian Acquired Immunodeficiency Syndrome	Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.	""	0	#FFFFFF
D016098	C01.207.800.350|C10.228.228.800.350|C10.574.500.425|C10.574.843.400|C16.320.400.350	Gerstmann-Straussler-Scheinker Disease	An autosomal dominant familial prion disease with a wide spectrum of clinical presentations including ATAXIA, spastic paraparesis, extrapyramidal signs, and DEMENTIA. Clinical onset is in the third to sixth decade of life and the mean duration of illness prior to death is five years. Several kindreds with variable clinical and pathologic features have been described. Pathologic features include cerebral prion protein amyloidosis, and spongiform or neurofibrillary degeneration. (From Brain Pathol 1998 Jul;8(3):499-513; Brain Pathol 1995 Jan;5(1):61-75)	""	0	#FFFFFF
D016103	C26.117.500.500|C26.404.812	Spinal Fractures	Broken bones in the vertebral column.	""	0	#FFFFFF
D016104	C12.050.703.560	Oligohydramnios	A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.	""	0	#FFFFFF
D016107	C16.131.831.493.080|C17.800.804.493.080|C17.800.827.275.080|C17.800.865.410.080	Epidermolysis Bullosa Acquisita	Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.	""	0	#FFFFFF
D016108	C16.131.831.493.160|C16.320.850.275.160|C17.300.200.367|C17.800.804.493.160|C17.800.827.275.160|C17.800.865.410.160	Epidermolysis Bullosa Dystrophica	Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.	""	0	#FFFFFF
D016109	C16.131.831.493.170|C16.320.850.275.170|C17.800.804.493.170|C17.800.827.275.170|C17.800.865.410.170	Epidermolysis Bullosa, Junctional	Form of epidermolysis bullosa having onset at birth or during the neonatal period and transmitted through autosomal recessive inheritance. It is characterized by generalized blister formation, extensive denudation, and separation and cleavage of the basal cell plasma membranes from the basement membrane.	""	0	#FFFFFF
D016110	C16.131.831.493.180|C16.320.850.275.180|C17.800.804.493.180|C17.800.827.275.180|C17.800.865.410.180	Epidermolysis Bullosa Simplex	A form of epidermolysis bullosa characterized by serous bullae that heal without scarring. Mutations in the genes that encode KERATIN-5 and KERATIN-14 have been associated with several subtypes of epidermolysis bullosa simplex.	""	0	#FFFFFF
D016111	C16.131.831.512.723|C16.320.565.398.641.723|C16.320.850.820|C16.614.492.723|C17.800.428.333.723|C17.800.804.512.723|C17.800.827.820|C18.452.584.563.641.723|C18.452.648.398.641.723	Sjogren-Larsson Syndrome	An autosomal recessive neurocutaneous disorder characterized by severe ichthyosis MENTAL RETARDATION; SPASTIC PARAPLEGIA; and congenital ICHTHYOSIS. It is caused by mutation of gene encoding microsomal fatty ALDEHYDE DEHYDROGENASE leading to defect in fatty alcohol metabolism.	""	0	#FFFFFF
D016112	C16.131.831.512.410|C16.320.850.405|C17.800.428.333.410|C17.800.804.512.410|C17.800.827.405	Ichthyosis Vulgaris	Most common form of ICHTHYOSIS characterized by prominent scaling especially on the exterior surfaces of the extremities. It is inherited as an autosomal dominant trait.	""	0	#FFFFFF
D016113	C16.131.831.512.400|C16.320.850.400|C16.614.492.400|C17.800.428.333.250|C17.800.804.512.400|C17.800.827.400	Ichthyosiform Erythroderma, Congenital	Designation for several severe forms of ichthyosis, present at birth, that are characterized by hyperkeratotic scaling. Infants may be born encased in a collodion membrane which begins shedding within 24 hours. This is followed in about two weeks by persistent generalized scaling. The forms include bullous (HYPERKERATOSIS, EPIDERMOLYTIC), non-bullous (ICHTHYOSIS, LAMELLAR), wet type, and dry type.	""	0	#FFFFFF
D016114	C16.131.831.512.420|C16.320.322.241|C16.320.565.925.400|C16.320.850.408|C16.614.492.420|C17.800.428.333.420|C17.800.804.512.420|C17.800.827.408|C18.452.648.925.400	Ichthyosis, X-Linked	Chronic form of ichthyosis that is inherited as a sex-linked recessive trait carried on the X-chromosome and transmitted to the male offspring. It is characterized by severe scaling, especially on the extremities, and is associated with steroid sulfatase deficiency.	""	0	#FFFFFF
D016115	C11.270.040.545|C16.320.290.040.100|C16.320.565.100.102.100|C16.320.850.080.100|C17.800.621.440.102.100|C17.800.827.080.100|C18.452.648.100.102.100	Albinism, Oculocutaneous	Heterogeneous group of autosomal recessive disorders comprising at least four recognized types, all having in common varying degrees of hypopigmentation of the skin, hair, and eyes. The two most common are the tyrosinase-positive and tyrosinase-negative types.	""	0	#FFFFFF
D016116	C16.320.290.040.600|C16.320.565.100.102.600|C16.320.850.080.600|C17.800.621.440.102.600|C17.800.827.080.600|C18.452.648.100.102.600	Piebaldism	Autosomal dominant, congenital disorder characterized by localized hypomelanosis of the skin and hair. The most familiar feature is a white forelock presenting in 80 to 90 percent of the patients. The underlying defect is possibly related to the differentiation and migration of melanoblasts, as well as to defective development of the neural crest (neurocristopathy). Piebaldism may be closely related to WAARDENBURG SYNDROME.	""	0	#FFFFFF
D016117	C11.270.040.090|C16.320.290.040.090|C16.320.565.100.102.090|C16.320.850.080.090|C17.800.621.440.102.090|C17.800.827.080.090|C18.452.648.100.102.090	Albinism, Ocular	Albinism affecting the eye in which pigment of the hair and skin is normal or only slightly diluted. The classic type is X-linked (Nettleship-Falls), but an autosomal recessive form also exists. Ocular abnormalities may include reduced pigmentation of the iris, nystagmus, photophobia, strabismus, and decreased visual acuity.	""	0	#FFFFFF
D016127	C14.280.484.400	Heart Valve Prolapse	Downward displacement of any one of the HEART VALVES from its normal position. This usually results in failed valve closure.	""	0	#FFFFFF
D016135	C10.500.680.800|C16.131.666.680.800	Spinal Dysraphism	Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)	""	0	#FFFFFF
D016136	C10.500.680.800.750|C16.131.666.680.800.750	Spina Bifida Occulta	A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34)	""	0	#FFFFFF
D016137	C10.500.680.800.730|C16.131.666.680.800.730	Spina Bifida Cystica	A form of spinal dysraphism associated with a protruding cyst made up of either meninges (i.e., a MENINGOCELE) or meninges in combination with spinal cord tissue (i.e., a MENINGOMYELOCELE). These lesions are frequently associated with spinal cord dysfunction, HYDROCEPHALUS, and SYRINGOMYELIA. (From Davis et al., Textbook of Neuropathology, 2nd ed, pp224-5)	""	0	#FFFFFF
D016142	C05.660.207.410|C10.500.034.875|C16.131.077.410|C16.131.260.380|C16.131.621.207.410|C16.131.666.034.875|C16.320.180.380	Holoprosencephaly	Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe INTELLECTUAL DISABILITY; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of INTELLECTUAL DISABILITY. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild INTELLECTUAL DISABILITY to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.	""	0	#FFFFFF
D016154	C06.267|C23.300.575.185	Digestive System Fistula	An abnormal passage communicating between any components of the digestive system, or between any part of the digestive system and surrounding organ(s).	""	0	#FFFFFF
D016155	C07.465.614|C23.300.575.500	Oral Fistula	An abnormal passage within the mouth communicating between two or more anatomical structures.	""	0	#FFFFFF
D016156	C08.702|C23.300.575.687	Respiratory Tract Fistula	An abnormal passage communicating between any component of the respiratory tract or between any part of the respiratory system and surrounding organs.	""	0	#FFFFFF
D016157	C14.240.850.984|C14.907.933|C23.300.575.950	Vascular Fistula	An abnormal passage between two or more BLOOD VESSELS, between ARTERIES; VEINS; or between an artery and a vein.	""	0	#FFFFFF
D016170	C14.280.067.845.940.349|C14.280.123.875.940.349|C23.550.073.845.940.349	Accelerated Idioventricular Rhythm	A type of automatic, not reentrant, ectopic ventricular rhythm with episodes lasting from a few seconds to a minute which usually occurs in patients with acute myocardial infarction or with DIGITALIS toxicity. The ventricular rate is faster than normal but slower than tachycardia, with an upper limit of 100 -120 beats per minute. Suppressive therapy is rarely necessary.	""	0	#FFFFFF
D016171	C14.280.067.845.940.700|C14.280.123.875.940.700|C23.550.073.845.940.700	Torsades de Pointes	A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.	""	0	#FFFFFF
D016180	C01.925.782.815.616	Lentivirus Infections	Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.	""	0	#FFFFFF
D016181	C01.925.782.815.616.350|C01.925.839.400|C22.180.350	Feline Acquired Immunodeficiency Syndrome	Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV).	""	0	#FFFFFF
D016182	C01.925.782.815.616.900|C01.925.839.900|C22.836.900	Visna	Demyelinating leukoencephalomyelitis of sheep caused by the VISNA-MAEDI VIRUS. It is similar to but not the same as SCRAPIE.	""	0	#FFFFFF
D016183	C01.925.782.815.650|C01.925.928.650|C22.795.650	Murine Acquired Immunodeficiency Syndrome	Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas.	""	0	#FFFFFF
D016262	C01.207.618.750.750|C01.925.782.687.359.764.650|C05.651.534.750|C10.228.228.618.750.750|C10.228.854.525.850.750|C10.574.827|C10.586.750.850.750|C10.668.491.175.750|C10.668.864.500	Postpoliomyelitis Syndrome	A syndrome characterized by new neuromuscular symptoms that occur at least 15 years after clinical stability has been attained in patients with a prior history of symptomatic poliomyelitis. Clinical features include new muscular weakness and atrophy of the limbs, bulbar innervated musculature, and muscles of respiration, combined with excessive fatigue, joint pain, and reduced stamina. The process is marked by slow progression and periods of stabilization. (From Ann NY Acad Sci 1995 May 25;753:68-80)	""	0	#FFFFFF
D016263	C01.221.250.875.050|C01.221.812.640.400.072|C01.778.640.400.072|C01.925.782.815.616.400.050|C01.925.813.400.072|C12.050.351.968.419.050|C12.100.937.640.400.072|C12.200.777.419.050|C12.950.419.050|C20.673.480.050	AIDS-Associated Nephropathy	Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.	""	0	#FFFFFF
D016269	C20.543.480.370.500	Milk Hypersensitivity	Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.	""	0	#FFFFFF
D016301	C05.116.264.150|C07.465.714.354.500	Alveolar Bone Loss	Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.	""	0	#FFFFFF
D016369	C07.793.208.688	Smear Layer	Adherent debris produced when cutting the enamel or dentin in cavity preparation. It is about 1 micron thick and its composition reflects the underlying dentin, although different quantities and qualities of smear layer can be produced by the various instrumentation techniques. Its function is presumed to be protective, as it lowers dentin permeability. However, it masks the underlying dentin and interferes with attempts to bond dental material to the dentin.	""	0	#FFFFFF
D016388	C07.465.714.804|C07.793.870	Tooth Loss	The failure to retain teeth as a result of disease or injury.	""	0	#FFFFFF
D016393	C04.557.386.480.150|C15.604.515.569.480.150|C20.683.515.761.480.150	Lymphoma, B-Cell	A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.	""	0	#FFFFFF
D016399	C04.557.386.480.750|C15.604.515.569.480.750|C20.683.515.761.480.750	Lymphoma, T-Cell	A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.	""	0	#FFFFFF
D016400	C04.557.386.480.493|C15.604.515.569.480.493|C20.683.515.761.480.487	Lymphoma, Large-Cell, Immunoblastic	Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.	""	0	#FFFFFF
D016403	C04.557.386.480.150.585|C15.604.515.569.480.150.585|C20.683.515.761.480.150.585	Lymphoma, Large B-Cell, Diffuse	Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.	""	0	#FFFFFF
D016410	C04.557.386.480.750.800|C15.604.515.569.480.750.800|C20.683.515.761.480.750.800	Lymphoma, T-Cell, Cutaneous	A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.	""	0	#FFFFFF
D016411	C04.557.386.480.750.825|C15.604.515.569.480.750.825|C20.683.515.761.480.750.825	Lymphoma, T-Cell, Peripheral	A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.	""	0	#FFFFFF
D016459	C01.685|C23.550.767.868	Prosthesis-Related Infections	Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).	""	0	#FFFFFF
D016460	C17.300.200.495.380|C17.800.550.380|C23.550.382.375	Granuloma Annulare	Benign granulomatous disease of unknown etiology characterized by a ring of localized or disseminated papules or nodules on the skin and palisading histiocytes surrounding necrobiotic tissue resulting from altered collagen structures.	""	0	#FFFFFF
D016463	C17.800.229.800	Sweet Syndrome	Condition characterized by large, rapidly extending, erythematous, tender plaques on the upper body usually accompanied by fever and dermal infiltration of neutrophilic leukocytes. It occurs mostly in middle-aged women, is often preceded by an upper respiratory infection, and clinically resembles ERYTHEMA MULTIFORME. Sweet syndrome is associated with LEUKEMIA.	""	0	#FFFFFF
D016464	C16.320.565.595|C18.452.648.595	Lysosomal Storage Diseases	Inborn errors of metabolism characterized by defects in specific lysosomal hydrolases and resulting in intracellular accumulation of unmetabolized substrates.	""	0	#FFFFFF
D016469	C01.150.703.492.594|C01.757.360|C23.550.470.790.500.360	Fungemia	The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.	""	0	#FFFFFF
D016470	C01.150.252.100|C01.757.100|C23.550.470.790.500.100	Bacteremia	The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.	""	0	#FFFFFF
D016471	C12.050.351.500.056.630.642|C12.100.250.056.630.642|C19.391.630.642	Ovarian Hyperstimulation Syndrome	A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.	""	0	#FFFFFF
D016472	C10.574.562|C10.668.467	Motor Neuron Disease	Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)	""	0	#FFFFFF
D016481	C01.150.252.400.466	Helicobacter Infections	Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.	""	0	#FFFFFF
D016483	C04.557.386.480.150.450|C15.604.515.569.480.150.450|C20.683.515.761.480.150.450	Lymphoma, AIDS-Related	B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.	""	0	#FFFFFF
D016489	C10.900.300.350|C26.915.300.450|C26.974.382	Head Injuries, Closed	Traumatic injuries to the cranium where the integrity of the skull is not compromised and no bone fragments or other objects penetrate the skull and DURA MATER. This frequently results in mechanical injury being transmitted to intracranial structures which may produce TRAUMATIC BRAIN INJURIES, hemorrhage, or CRANIAL NERVE INJURIES. (From Rowland, Merritt's Textbook of Neurology, 9th ed, p417)	""	0	#FFFFFF
D016491	C14.907.617	Peripheral Vascular Diseases	Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.	""	0	#FFFFFF
D016506	C16.320.850.700|C17.800.827.700|C17.800.865.858	Pemphigus, Benign Familial	An autosomal dominantly inherited skin disorder characterized by recurrent eruptions of vesicles and BULLAE mainly on the neck, axillae, and groin. Mutations in the ATP2C1 gene (encoding the secretory pathway Ca2++/Mn2++ ATPase 1 (SPCA1)) cause this disease. It is clinically and histologically similar to DARIER DISEASE - both have abnormal, unstable DESMOSOMES between KERATINOCYTES and defective CALCIUM-TRANSPORTING ATPASES. It is unrelated to PEMPHIGUS VULGARIS though it closely resembles that disease.	""	0	#FFFFFF
D016510	C11.204.290|C23.550.589.500.435	Corneal Neovascularization	New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.	""	0	#FFFFFF
D016511	C16.320.798.750|C16.614.815|C18.452.284.800|C20.673.795.750	Severe Combined Immunodeficiency	Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).	""	0	#FFFFFF
D016512	C26.558.100	Ankle Injuries	Harm or hurt to the ankle or ankle joint usually inflicted by an external source.	""	0	#FFFFFF
D016518	C04.557.465.625.650.595.610.500|C04.557.580.600.580.590.655|C04.557.580.600.610.595.610.500|C04.700.631.655|C09.218.807.800.675.500|C09.647.675.500|C10.292.225.750.500|C10.292.910.600.500|C10.562.600.750|C10.574.500.549.700|C16.320.400.560.700|C16.320.700.633.655	Neurofibromatosis 2	An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.	""	0	#FFFFFF
D016523	C17.800.321.250|C17.800.893.592.450	Foot Ulcer	Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.	""	0	#FFFFFF
D016532	C10.597.606.360.455.750|C16.320.322.500.750|C16.320.400.525.750|C16.320.565.202.715.645|C16.320.565.595.600.645|C17.300.550.575.645|C18.452.648.202.715.645|C18.452.648.595.600.645	Mucopolysaccharidosis II	Systemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.	""	0	#FFFFFF
D016534	C14.280.142|C23.888.176	Cardiac Output, High	A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. These conditions may include ANEMIA; ARTERIOVENOUS FISTULA; THYROTOXICOSIS; PREGNANCY; EXERCISE; FEVER; and HYPOXIA. In time, compensatory changes of the heart can lead to pathological form of high cardiac output and eventual HEART FAILURE.	""	0	#FFFFFF
D016535	C08.127.210	Bronchial Hyperreactivity	Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.	""	0	#FFFFFF
D016537	C10.228.140.163.100.435.825.300.400|C16.320.565.189.435.825.300.400|C16.320.565.398.641.803.350.360|C16.320.565.595.554.825.300.400|C18.452.132.100.435.825.300.400|C18.452.584.563.641.803.350.360|C18.452.648.189.435.825.300.400|C18.452.648.398.641.803.350.360|C18.452.648.595.554.825.300.400	Gangliosidosis, GM1	An autosomal recessive neurodegenerative disorder caused by the absence or deficiency of BETA-GALACTOSIDASE. It is characterized by intralysosomal accumulation of G(M1) GANGLIOSIDE and oligosaccharides, primarily in neurons of the central nervous system. The infantile form is characterized by MUSCLE HYPOTONIA, poor psychomotor development, HIRSUTISM, hepatosplenomegaly, and facial abnormalities. The juvenile form features HYPERACUSIS; SEIZURES; and psychomotor retardation. The adult form features progressive DEMENTIA; ATAXIA; and MUSCLE SPASTICITY. (From Menkes, Textbook of Child Neurology, 5th ed, pp96-7)	""	0	#FFFFFF
D016538	C16.320.565.202.715.675|C16.320.565.595.600.675|C17.300.550.575.675|C18.452.648.202.715.675|C18.452.648.595.600.675	Mucopolysaccharidosis VII	Mucopolysaccharidosis characterized by excessive dermatan and heparan sulfates in the urine and Hurler-like features. It is caused by a deficiency of beta-glucuronidase.	""	0	#FFFFFF
D016543	C04.588.614.250|C10.551.240	Central Nervous System Neoplasms	Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.	""	0	#FFFFFF
D016545	C04.588.614.250.195.205.200|C10.228.140.211.280.300|C10.551.240.250.200.200	Choroid Plexus Neoplasms	Benign or malignant tumors which arise from the choroid plexus of the ventricles of the brain. Papillomas (see PAPILLOMA, CHOROID PLEXUS) and carcinomas are the most common histologic subtypes, and tend to seed throughout the ventricular and subarachnoid spaces. Clinical features include headaches, ataxia and alterations of consciousness, primarily resulting from associated HYDROCEPHALUS. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072; J Neurosurg 1998 Mar;88(3):521-8)	""	0	#FFFFFF
D016553	C15.378.100.802.687.600|C15.378.140.855.925.750.600|C15.378.463.740|C20.111.759|C20.841.600|C23.550.414.950.687.600|C23.888.885.687.687.600	Purpura, Thrombocytopenic, Idiopathic	Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.	""	0	#FFFFFF
D016569	C11.250.090|C11.338.190|C16.131.384.190	Blepharophimosis	The abnormal narrowness of the palpebral fissure in the horizontal direction caused by the lateral displacement of the medial canthi of the eyelids. (Dorland, 27th ed)	""	0	#FFFFFF
D016575	C17.800.946.315	Hidradenitis	The inflammation of a sweat gland (usually of the apocrine type). The condition can be idiopathic or occur as a result of or in association with another underlying condition. Neutrophilic eccrine hidradenitis is a relatively rare variant that has been reported in patients undergoing chemotherapy, usually for non-Hodgkin lymphomas or leukemic conditions.	""	0	#FFFFFF
D016582	C01.925.782.815.622|C04.557.337.385|C22.180.500	Leukemia, Feline	A neoplastic disease of cats frequently associated with feline leukemia virus infection.	""	0	#FFFFFF
D016583	C01.925.782.815.200.260|C04.557.337.100|C20.673.483.260|C22.196.260	Enzootic Bovine Leukosis	A lymphoid neoplastic disease in cattle caused by the bovine leukemia virus. Enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukemia but the presence of malignant cells in the blood is not a consistent finding.	""	0	#FFFFFF
D016585	C01.150.252.954|C12.050.351.500.894.906.800|C12.100.250.894.906.800	Vaginosis, Bacterial	Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.	""	0	#FFFFFF
D016586	C04.557.450.590.350	Granular Cell Tumor	Unusual tumor affecting any site of the body, but most often encountered in the head and neck. Considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. It affects women more often than men. When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.	""	0	#FFFFFF
D016602	C26.986.950.500	Needlestick Injuries	Penetrating stab wounds caused by needles. They are of special concern to health care workers since such injuries put them at risk for developing infectious disease.	""	0	#FFFFFF
D016603	C05.651.290|C10.668.491.050|C15.378.553.231.335	Eosinophilia-Myalgia Syndrome	A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)	""	0	#FFFFFF
D016606	C04.588.322.894.800|C04.588.443.915.800|C19.344.894.800|C19.874.788.800	Thyroid Nodule	A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).	""	0	#FFFFFF
D016609	C04.692	Neoplasms, Second Primary	Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.	""	0	#FFFFFF
D016638	C23.550.291.625	Critical Illness	A disease or state in which death is possible or imminent.	""	0	#FFFFFF
D016640	C12.050.703.170|C18.452.394.750.448|C19.246.200	Diabetes, Gestational	Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.	""	0	#FFFFFF
D016643	C01.207.800.260|C10.228.228.800.260|C10.574.843.300|C22.196.250	Encephalopathy, Bovine Spongiform	A transmissible spongiform encephalopathy of cattle associated with abnormal prion proteins in the brain. Affected animals develop excitability and salivation followed by ATAXIA. This disorder has been associated with consumption of SCRAPIE infected ruminant derived protein. This condition may be transmitted to humans, where it is referred to as variant or new variant CREUTZFELDT-JAKOB SYNDROME. (Vet Rec 1998 Jul 25;143(41):101-5)	""	0	#FFFFFF
D016649	C12.050.351.500.056.630.750|C12.100.250.056.630.750|C19.391.630.750	Primary Ovarian Insufficiency	Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.	""	0	#FFFFFF
D016657	C10.228.140.300.510.200.200|C14.907.253.560.200.200|C18.452.845.500.100	Cerebral Amyloid Angiopathy	A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)	""	0	#FFFFFF
D016659	C01.830.025.700	Psoas Abscess	Abscess of the PSOAS MUSCLES resulting usually from disease of the lumbar vertebrae, with the pus descending into the muscle sheath. The infection is most commonly tuberculous or staphylococcal.	""	0	#FFFFFF
D016672	C06.405.205.282.750.625.900|C23.300.415.625.900	Zenker Diverticulum	A DIVERTICULUM at the upper end of the ESOPHAGUS through the cricopharyngeal muscle at the junction of the PHARYNX and the esophagus.	""	0	#FFFFFF
D016697	C01.925.256.466.930.750.733|C07.465.299.750|C09.218.513|C10.292.319.750	Herpes Zoster Oticus	A syndrome characterized by facial palsy in association with a herpetic eruption of the external auditory meatus. This may occasionally be associated with tinnitus, vertigo, deafness, severe otalgia, and inflammation of the pinna. The condition is caused by reactivation of a latent HERPESVIRUS 3, HUMAN infection which causes inflammation of the facial and vestibular nerves, and may occasionally involve additional cranial nerves. (From Adams et al., Principles of Neurology, 6th ed, p757)	""	0	#FFFFFF
D016706	C05.550.114.154.870|C05.799.114.870|C17.300.775.099.870|C20.111.199.870	Still's Disease, Adult-Onset	Systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.	""	0	#FFFFFF
D016710	C23.550.972	Yin Deficiency	In the YIN-YANG system of philosophy and medicine, an insufficiency of body fluid (called yinxu), manifesting often as irritability, thirst, constipation, etc. (The Pinyin Chinese-English Dictionary, 1979).	""	0	#FFFFFF
D016711	C23.550.945	Yang Deficiency	In the YIN-YANG system of philosophy and medicine, a lack of vital energy (called yangxu in Chinese). It manifests itself in various systemic and organic diseases. (The Pinyin Chinese-English Dictionary, 1979)	""	0	#FFFFFF
D016715	C04.445.435.500|C04.651.435.500|C05.116.099.750|C05.660.585.620|C16.131.077.740|C16.131.621.585.620	Proteus Syndrome	"Hamartoneoplastic malformation syndrome of uncertain etiology characterized by partial GIGANTISM of the hands and/or feet, asymmetry of the limbs, plantar hyperplasia, hemangiomas (HEMANGIOMA), lipomas (LIPOMA), lymphangiomas (LYMPHANGIOMA), epidermal NEVI; MACROCEPHALY; cranial HYPEROSTOSIS, and long-bone overgrowth. Joseph Merrick, the so-called ""elephant man"", apparently suffered from Proteus syndrome and not NEUROFIBROMATOSIS, a disorder with similar characteristics."	""	0	#FFFFFF
D016720	C01.150.703.770	Pneumocystis Infections	Infections with species in the genus PNEUMOCYSTIS, a fungus causing interstitial plasma cell pneumonia (PNEUMONIA, PNEUMOCYSTIS) and other infections in humans and other MAMMALS. Immunocompromised patients, especially those with AIDS, are particularly susceptible to these infections. Extrapulmonary sites are rare but seen occasionally.	""	0	#FFFFFF
D016724	C01.748.265|C01.830.305.310|C08.528.240|C08.730.265|C23.550.470.756.305.250	Empyema, Pleural	Suppurative inflammation of the pleural space.	""	0	#FFFFFF
D016726	C08.381.600	Plasma Cell Granuloma, Pulmonary	A tumor-like inflammatory lesion of the lung that is composed of PLASMA CELLS and fibrous tissue. It is also known as an inflammatory pseudotumor, often with calcification and measuring between 2 and 5 cm in diameter.	""	0	#FFFFFF
D016727	C11.675.679	Orbital Pseudotumor	A nonspecific tumor-like inflammatory lesion in the ORBIT of the eye. It is usually composed of mature LYMPHOCYTES; PLASMA CELLS; MACROPHAGES; LEUKOCYTES with varying degrees of FIBROSIS. Orbital pseudotumors are often associated with inflammation of the extraocular muscles (ORBITAL MYOSITIS) or inflammation of the lacrimal glands (DACRYOADENITIS).	""	0	#FFFFFF
D016731	C01.925.256.700.300|C01.925.825.260|C17.800.229.335|C17.800.838.790.260	Erythema Infectiosum	Contagious infection with human B19 Parvovirus most commonly seen in school age children and characterized by fever, headache, and rashes of the face, trunk, and extremities. It is often confused with RUBELLA.	""	0	#FFFFFF
D016736	C20.111.197	Antiphospholipid Syndrome	The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).	""	0	#FFFFFF
D016738	C06.130.120.135.250.125|C06.552.150.125|C14.240.400.044|C16.131.077.065|C16.131.240.400.044|C16.320.051	Alagille Syndrome	A multisystem disorder that is characterized by aplasia of intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC), and malformations in the cardiovascular system, the eyes, the vertebral column, and the facies. Major clinical features include JAUNDICE, and congenital heart disease with peripheral PULMONARY STENOSIS. Alagille syndrome may result from heterogeneous gene mutations, including mutations in JAG1 on CHROMOSOME 20 (Type 1) and NOTCH2 on CHROMOSOME 1 (Type 2).	""	0	#FFFFFF
D016750	C10.114.812|C10.228.854.790|C10.668.900|C20.111.258.850	Stiff-Person Syndrome	A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)	""	0	#FFFFFF
D016751	C01.925.440.470|C01.925.782.455|C06.552.380.705.470	Hepatitis E	Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.	""	0	#FFFFFF
D016757	C14.280.383.220|C23.550.260.322.250	Death, Sudden, Cardiac	Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)	""	0	#FFFFFF
D016766	C01.925.782.600.550.200.360|C22.180.440	Feline Infectious Peritonitis	Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.	""	0	#FFFFFF
D016767	C06.130.120.127.500|C06.198.184.500|C16.131.077.245.250|C16.131.314.184.500|C16.320.184.250	Caroli Disease	Congenital cystic dilatation of the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). It consists of 2 types: simple Caroli disease is characterized by bile duct dilatation (ectasia) alone; and complex Caroli disease is characterized by bile duct dilatation with extensive hepatic fibrosis and portal hypertension (HYPERTENSION, PORTAL). Benign renal tubular ectasia is associated with both types of Caroli disease.	""	0	#FFFFFF
D016769	C14.907.355	Embolism and Thrombosis	A collective term for pathological conditions which are caused by the formation of a blood clot (THROMBUS) in a blood vessel, or by blocking of a blood vessel with an EMBOLUS, undissolved materials in the blood stream.	""	0	#FFFFFF
D016770	C01.610.752.200	Ciliophora Infections	Infections with protozoa of the phylum CILIOPHORA.	""	0	#FFFFFF
D016773	C01.610.752.300.500.400|C01.610.858.560.400|C01.920.813.400|C17.800.838.775.560.400	Leishmaniasis, Cutaneous	An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.	""	0	#FFFFFF
D016774	C01.610.752.300.500.400.350|C01.610.858.560.400.350|C01.920.813.400.350|C17.800.838.775.560.400.350	Leishmaniasis, Diffuse Cutaneous	A form of LEISHMANIASIS, CUTANEOUS caused by Leishmania aethiopica in Ethiopia and Kenya, L. pifanoi in Venezuela, L. braziliensis in South America, and L. mexicana in Central America. This disease is characterized by massive dissemination of skin lesions without visceral involvement.	""	0	#FFFFFF
D016776	C01.610.432.250|C01.610.752.049.250|C06.405.469.452.250	Blastocystis Infections	Infections with organisms of the genus BLASTOCYSTIS. The species B. hominis is responsible for most infections. Parasitologic surveys have generally found small numbers of this species in human stools, but higher positivity rates and organism numbers in AIDS patients and other immunosuppressed patients (IMMUNOCOMPROMISED HOST). Symptoms include ABDOMINAL PAIN; DIARRHEA; CONSTIPATION; VOMITING; and FATIGUE.	""	0	#FFFFFF
D016778	C01.610.752.530.650|C01.920.875.650	Malaria, Falciparum	Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	""	0	#FFFFFF
D016779	C01.207.205.300.500|C01.610.105.300.500|C01.610.752.530.620|C01.920.875.620|C10.228.228.205.300.500	Malaria, Cerebral	A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)	""	0	#FFFFFF
D016780	C01.610.752.530.700|C01.920.875.700	Malaria, Vivax	Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day.	""	0	#FFFFFF
D016781	C01.207.090.800|C01.207.205.300.800|C01.610.105.300.800|C01.610.752.250.800.250|C01.830.025.160.800|C10.228.140.116.800|C10.228.228.090.800|C10.228.228.205.300.800	Toxoplasmosis, Cerebral	Infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)	""	0	#FFFFFF
D016849	C01.375.725.465|C01.925.256.466.382.465|C01.925.325.465|C11.204.564.425|C11.294.800.475	Keratitis, Herpetic	A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)	""	0	#FFFFFF
D016857	C23.888.852.614	Hypocapnia	Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood.	""	0	#FFFFFF
D016862	C01.150.252.223.850.400|C01.150.252.410.040.552.846.493.400|C01.150.252.410.040.552.846.570.300|C01.207.180.850.400|C10.228.228.180.850.400	Tuberculoma, Intracranial	A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with SEIZURES, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as OPPORTUNISTIC INFECTIONS, but also occur in immunocompetent individuals.	""	0	#FFFFFF
D016863	C01.150.252.410.090	Bacillaceae Infections	Infections with bacteria of the family BACILLACEAE.	""	0	#FFFFFF
D016864	C04.700.600|C16.320.700.600|C18.452.284.520	Li-Fraumeni Syndrome	Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.	""	0	#FFFFFF
D016866	C01.150.252.400.110	Bacteroidaceae Infections	Infections with bacteria of the family BACTEROIDACEAE.	""	0	#FFFFFF
D016868	C01.150.252.400.310.850	Serratia Infections	Infections with bacteria of the genus SERRATIA.	""	0	#FFFFFF
D016869	C01.150.252.400.610.850	Ureaplasma Infections	Infections with bacteria of the genus UREAPLASMA.	""	0	#FFFFFF
D016870	C01.150.252.400.625	Neisseriaceae Infections	Infections with bacteria of the family NEISSERIACEAE.	""	0	#FFFFFF
D016871	C01.150.252.400.700	Pasteurellaceae Infections	Infections with bacteria of the family PASTEURELLACEAE.	""	0	#FFFFFF
D016873	C01.150.252.400.054.750|C01.150.252.400.285|C01.920.930.300	Ehrlichiosis	A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.	""	0	#FFFFFF
D016878	C10.668.829.800.700|C15.378.147.780.750|C16.131.077.703|C20.683.780.750	POEMS Syndrome	A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)	""	0	#FFFFFF
D016881	C01.150.703.617	Microsporidiosis	Infections with FUNGI of the phylum MICROSPORIDIA.	""	0	#FFFFFF
D016883	C18.452.076.176.652.500|C19.246.099.812	Diabetic Ketoacidosis	A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by KETOSIS; DEHYDRATION; and depressed consciousness leading to COMA.	""	0	#FFFFFF
D016884	C19.787|C20.111.750	Polyendocrinopathies, Autoimmune	Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.	""	0	#FFFFFF
D016888	C14.907.075	Angiodysplasia	Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.	""	0	#FFFFFF
D016889	C04.588.945.418.948.585|C12.050.351.500.852.762.200|C12.050.351.937.418.875.200|C12.100.250.852.762.200|C12.900.418.875.200	Endometrial Neoplasms	Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.	""	0	#FFFFFF
D016890	C01.150.703.617.300	Encephalitozoonosis	Infection with FUNGI of the genus ENCEPHALITOZOON. Lesions commonly occur in the BRAIN and KIDNEY tubules. Other sites of infection in MAMMALS are the LIVER; ADRENAL GLANDS; OPTIC NERVES; RETINA; and MYOCARDIUM.	""	0	#FFFFFF
D016891	C12.050.351.968.419.403.875.500|C12.200.777.419.403.875.500|C12.950.419.403.875.500|C16.131.077.717.500|C16.320.184.625.500	Polycystic Kidney, Autosomal Dominant	Kidney disorders with autosomal dominant inheritance and characterized by multiple CYSTS in both KIDNEYS with progressive deterioration of renal function.	""	0	#FFFFFF
D016893	C10.228.140.300.200.360|C14.907.137.230|C14.907.253.123.360	Carotid Stenosis	Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)	""	0	#FFFFFF
D016905	C01.150.252.400	Gram-Negative Bacterial Infections	Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.	""	0	#FFFFFF
D016908	C01.150.252.410	Gram-Positive Bacterial Infections	Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.	""	0	#FFFFFF
D016916	C05.550.515	Joint Deformities, Acquired	Deformities acquired after birth as the result of injury or disease. The joint deformity is often associated with rheumatoid arthritis and leprosy.	""	0	#FFFFFF
D016917	C01.150.252.400.126.100.075|C01.150.252.819.150|C01.800.720.150|C14.907.077.060|C17.800.838.765.150|C17.800.862.060	Angiomatosis, Bacillary	A reactive vascular proliferation that is characterized by the multiple tumor-like lesions in skin, bone, brain, and other organs. Bacillary angiomatosis is caused by infection with gram-negative Bartonella bacilli (such as BARTONELLA HENSELAE), and is often seen in AIDS patients and other IMMUNOCOMPROMISED HOSTS.	""	0	#FFFFFF
D016918	C01.100.500|C05.116.900.853.625.800.637|C05.550.114.099.500|C05.550.114.865.800.637	Arthritis, Reactive	An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.	""	0	#FFFFFF
D016919	C01.150.703.181.500.500|C01.150.703.248.290|C01.207.198.500.500|C10.228.228.198.500.500|C10.586.625.300.500	Meningitis, Cryptococcal	Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)	""	0	#FFFFFF
D016920	C01.150.252.223.500|C01.207.180.500|C10.228.228.180.500|C10.586.625.280	Meningitis, Bacterial	Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.	""	0	#FFFFFF
D016921	C01.150.703.181.500|C01.207.198.500|C10.228.228.198.500|C10.586.625.300	Meningitis, Fungal	Meningitis caused by fungal agents which may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.	""	0	#FFFFFF
D017001	C07.793.720	Tooth Demineralization	A tooth's loss of minerals, such as calcium in hydroxyapatite from the tooth matrix, caused by acidic exposure. An example of the occurrence of demineralization is in the formation of dental caries.	""	0	#FFFFFF
D017029	C10.228.140.490.360.260	Epilepsy, Complex Partial	A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)	""	0	#FFFFFF
D017034	C10.228.140.490.360.270|C10.228.140.490.493.188	Epilepsy, Frontal Lobe	A localization-related (focal) form of epilepsy characterized by seizures which arise in the FRONTAL LOBE.	""	0	#FFFFFF
D017036	C10.597.742.785.260|C23.888.592.742.785.260	Epilepsia Partialis Continua	A variant of EPILEPSY characterized by continuous focal jerking of a body part over a period of hours, days, or even years without spreading to other body regions. Contractions may be aggravated by movement and are reduced, but not abolished during sleep. ELECTROENCEPHALOGRAPHY demonstrates epileptiform (spike and wave) discharges over the hemisphere opposite to the affected limb in most instances. The repetitive movements may originate from the CEREBRAL CORTEX or from subcortical structures (e.g., BRAIN STEM; BASAL GANGLIA). This condition is associated with Russian Spring and Summer encephalitis (see ENCEPHALITIS, TICK BORNE); Rasmussen syndrome (see ENCEPHALITIS); MULTIPLE SCLEROSIS; DIABETES MELLITUS; BRAIN NEOPLASMS; and CEREBROVASCULAR DISORDERS. (From Brain, 1996 April;119(pt2):393-407; Epilepsia 1993;34;Suppl 1:S29-S36; and Adams et al., Principles of Neurology, 6th ed, p319)	""	0	#FFFFFF
D017042	C10.228.140.163.100.687.500|C12.050.703.575|C16.320.565.100.766.500|C16.320.565.189.687.500|C18.452.132.100.687.500|C18.452.648.100.766.500|C18.452.648.189.687.500	Phenylketonuria, Maternal	A condition occurring in untreated or partially treated females with PHENYLKETONURIA when they become pregnant. This may result in damages to the FETUS, including MICROCEPHALY; MENTAL RETARDATION; congenital heart disease; FETAL GROWTH RETARDATION; and CRANIOFACIAL ABNORMALITIES. (From Am J Med Genet 1997 Mar 3;69(1):89-95)	""	0	#FFFFFF
D017043	C04.182.197|C11.338.300	Chalazion	A non-neoplastic cyst of the MEIBOMIAN GLANDS of the eyelid.	""	0	#FFFFFF
D017044	C12.050.351.968.419.403.875.510|C12.200.777.419.403.875.510|C12.950.419.403.875.510|C16.131.077.717.510|C16.320.184.625.510	Polycystic Kidney, Autosomal Recessive	A genetic disorder with autosomal recessive inheritance, characterized by multiple CYSTS in both KIDNEYS and associated LIVER lesions. Serious manifestations are usually present at BIRTH with high PERINATAL MORTALITY.	""	0	#FFFFFF
D017074	C20.673.330	Common Variable Immunodeficiency	Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.	""	0	#FFFFFF
D017085	C15.378.071.141.150.875.100|C15.378.420.826.100|C16.320.070.875.100|C16.320.365.826.100	alpha-Thalassemia	A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.	""	0	#FFFFFF
D017086	C15.378.071.141.150.875.150|C15.378.420.826.150|C16.320.070.875.150|C16.320.365.826.150	beta-Thalassemia	A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.	""	0	#FFFFFF
D017088	C01.221.250.875.100|C01.597.050|C01.610.684.050|C01.925.597.050|C01.925.782.815.616.400.100|C20.673.480.100	AIDS-Related Opportunistic Infections	Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.	""	0	#FFFFFF
D017091	C06.405.205.265.115|C06.405.469.158.188.115|C14.907.286	Colitis, Ischemic	Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature.	""	0	#FFFFFF
D017092	C16.320.850.738|C17.800.827.738|C18.452.811.250	Porphyria, Erythropoietic	An autosomal recessive porphyria that is due to a deficiency of UROPORPHYRINOGEN III SYNTHASE in the BONE MARROW; also known as congenital erythropoietic porphyria. This disease is characterized by SPLENOMEGALY; ANEMIA; photosensitivity; cutaneous lesions; accumulation of hydroxymethylbilane; and increased excretion of UROPORPHYRINS and COPROPORPHYRINS.	""	0	#FFFFFF
D017093	C06.552.308.500	Liver Failure	Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)	""	0	#FFFFFF
D017094	C06.552.830|C16.320.850.742|C17.800.827.742|C18.452.811.400	Porphyrias, Hepatic	A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.	""	0	#FFFFFF
D017096	C01.207.800|C10.228.228.800|C10.574.843	Prion Diseases	A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)	""	0	#FFFFFF
D017098	C15.378.147.333.500|C20.673.430.500	IgA Deficiency	A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.	""	0	#FFFFFF
D017099	C15.378.147.333.750|C20.673.430.750	IgG Deficiency	A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN G.	""	0	#FFFFFF
D017109	C10.228.662.037|C10.720.075|C23.888.592.350.600.500|C25.100.249|C25.723.705.100	Akathisia, Drug-Induced	A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often described as an inability to resist the urge to move.	""	0	#FFFFFF
D017114	C06.552.308.500.750	Liver Failure, Acute	A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.	""	0	#FFFFFF
D017116	C23.888.592.612.107.400	Low Back Pain	Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.	""	0	#FFFFFF
D017118	C06.552.830.150|C16.320.850.742.150|C17.800.827.742.150|C18.452.811.400.150	Porphyria, Acute Intermittent	An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.	""	0	#FFFFFF
D017119	C06.552.830.100|C16.320.850.742.250|C17.800.827.742.250|C18.452.811.400.250	Porphyria Cutanea Tarda	An autosomal dominant or acquired porphyria due to a deficiency of UROPORPHYRINOGEN DECARBOXYLASE in the LIVER. It is characterized by photosensitivity and cutaneous lesions with little or no neurologic symptoms. Type I is the acquired form and is strongly associated with liver diseases and hepatic toxicities caused by alcohol or estrogenic steroids. Type II is the familial form.	""	0	#FFFFFF
D017121	C06.552.830.437|C16.320.850.742.437|C17.800.827.742.437|C18.452.811.400.437	Porphyria, Hepatoerythropoietic	An autosomal recessive cutaneous porphyria that is due to a deficiency of UROPORPHYRINOGEN DECARBOXYLASE in both the LIVER and the BONE MARROW. Similar to PORPHYRIA CUTANEA TARDA, this disorder is caused by defects in the fifth enzyme in the 8-enzyme biosynthetic pathway of HEME, but is a homozygous enzyme deficiency with less than 10% of the normal enzyme activity. Cutaneous lesions are severe and mutilating.	""	0	#FFFFFF
D017129	C01.610.335.508.700.100.060|C01.610.432.060|C06.405.469.452.060	Anisakiasis	Infection with roundworms of the genus ANISAKIS. Human infection results from the consumption of fish harboring roundworm larvae. The worms may cause acute NAUSEA; VOMITING; or penetrate into the wall of the DIGESTIVE TRACT where they give rise to EOSINOPHILIC GRANULOMA in the STOMACH; INTESTINES; or the OMENTUM.	""	0	#FFFFFF
D017169	C04.666	Neoplasms, Post-Traumatic	Tumors, cancer or other neoplasms caused by or resulting from trauma or other non-radiation injuries.	""	0	#FFFFFF
D017180	C14.280.067.845.940|C14.280.123.875.940|C23.550.073.845.940	Tachycardia, Ventricular	An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).	""	0	#FFFFFF
D017188	C01.610.335.508.100	Adenophorea Infections	Infections with nematodes of the subclass ADENOPHOREA.	""	0	#FFFFFF
D017189	C01.610.335.508.100.275	Enoplida Infections	Infections with nematodes of the order ENOPLIDA.	""	0	#FFFFFF
D017190	C01.610.335.508.700	Secernentea Infections	Infections with nematodes of the subclass SECERNENTEA.	""	0	#FFFFFF
D017191	C01.610.335.508.700.100	Ascaridida Infections	Infections with nematodes of the order ASCARIDIDA.	""	0	#FFFFFF
D017192	C01.150.252.819|C01.800.720|C17.800.838.765	Skin Diseases, Bacterial	Skin diseases caused by bacteria.	""	0	#FFFFFF
D017193	C01.925.825|C17.800.838.790	Skin Diseases, Viral	Skin diseases caused by viruses.	""	0	#FFFFFF
D017194	C01.610.335.508.700.550	Oxyurida Infections	Infections with nematodes of the order OXYURIDA.	""	0	#FFFFFF
D017196	C01.610.335.508.700.700	Rhabditida Infections	Infections with nematodes of the order RHABDITIDA.	""	0	#FFFFFF
D017202	C14.280.647|C14.907.585	Myocardial Ischemia	A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).	""	0	#FFFFFF
D017204	C10.228.662.075|C16.131.077.095|C16.131.260.040|C16.320.180.040	Angelman Syndrome	"A syndrome characterized by multiple abnormalities, MENTAL RETARDATION, and movement disorders. Present usually are skull and other abnormalities, frequent infantile spasms (SPASMS, INFANTILE); easily provoked and prolonged paroxysms of laughter (hence ""happy""); jerky puppetlike movements (hence ""puppet""); continuous tongue protrusion; motor retardation; ATAXIA; MUSCLE HYPOTONIA; and a peculiar facies. It is associated with maternal deletions of chromosome 15q11-13 and other genetic abnormalities. (From Am J Med Genet 1998 Dec 4;80(4):385-90; Hum Mol Genet 1999 Jan;8(1):129-35)"	""	0	#FFFFFF
D017205	C01.610.335.508.700.750	Spirurida Infections	Infections with nematodes of the order SPIRURIDA.	""	0	#FFFFFF
D017206	C01.610.335.508.700.775	Strongylida Infections	Infections with nematodes of the order STRONGYLIDA.	""	0	#FFFFFF
D017213	C07.793.720.210.650	Root Caries	Dental caries involving the tooth root, cementum, or cervical area of the tooth.	""	0	#FFFFFF
D017219	C06.405.748.340	Gastric Outlet Obstruction	The hindering of output from the STOMACH into the SMALL INTESTINE. This obstruction may be of mechanical or functional origin such as EDEMA from PEPTIC ULCER; NEOPLASMS; FOREIGN BODIES; or AGING.	""	0	#FFFFFF
D017227	C01.610.335.508.700.100.850	Toxascariasis	Infections with nematodes of the genus TOXASCARIS.	""	0	#FFFFFF
D017229	C01.610.335.508.700.550.550.375	Enterobiasis	Infection with nematodes of the genus ENTEROBIUS; E. vermicularis, the pinworm of man, causes a crawling sensation and pruritus. This condition results in scratching the area, occasionally causing scarification.	""	0	#FFFFFF
D017237	C05.651.460.620|C10.228.140.163.540|C10.668.491.500.500|C18.452.132.540|C18.452.660.560.620	Mitochondrial Encephalomyopathies	A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. These are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (From Adams et al., Principles of Neurology, 6th ed, pp984-5)	""	0	#FFFFFF
D017240	C05.651.460|C10.668.491.500|C18.452.660.560	Mitochondrial Myopathies	A group of muscle diseases associated with abnormal mitochondria function.	""	0	#FFFFFF
D017241	C05.651.460.620.520|C10.228.140.163.100.535|C10.228.140.300.275.500|C10.668.491.500.500.500|C14.907.253.329.500|C16.320.565.189.535|C18.452.132.100.535|C18.452.648.189.535|C18.452.660.560.620.520	MELAS Syndrome	A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)	""	0	#FFFFFF
D017243	C05.651.460.620.530|C10.228.140.163.100.545|C10.228.140.490.375.130.650.700|C10.228.140.490.493.063.650.700|C10.668.491.500.500.550|C16.320.565.189.545|C18.452.132.100.545|C18.452.648.189.545|C18.452.660.560.620.530	MERRF Syndrome	A mitochondrial encephalomyopathy characterized clinically by a mixed seizure disorder, myoclonus, progressive ataxia, spasticity, and a mild myopathy. Dysarthria, optic atrophy, growth retardation, deafness, and dementia may also occur. This condition tends to present in childhood and to be transmitted via maternal lineage. Muscle biopsies reveal ragged-red fibers and respiratory chain enzymatic defects. (From Adams et al., Principles of Neurology, 6th ed, p986)	""	0	#FFFFFF
D017246	C05.651.460.700|C10.292.562.750.250|C10.597.622.447.511|C10.668.491.500.700|C11.590.472.250|C18.452.660.560.700|C23.550.291.500.688|C23.888.592.636.447.511	Ophthalmoplegia, Chronic Progressive External	A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)	""	0	#FFFFFF
D017250	C01.925.782.160	Caliciviridae Infections	Virus diseases caused by CALICIVIRIDAE. They include HEPATITIS E; VESICULAR EXANTHEMA OF SWINE; acute respiratory infections in felines, rabbit hemorrhagic disease, and some cases of gastroenteritis in humans.	""	0	#FFFFFF
D017253	C04.557.580.600.580.590|C04.700.631|C10.562.600|C10.574.500.549|C16.320.400.560|C16.320.700.633	Neurofibromatoses	A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)	""	0	#FFFFFF
D017254	C04.697.645.500|C23.550.727.645.500	Leukemic Infiltration	A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site.	""	0	#FFFFFF
D017271	C05.500.607.221|C05.651.243|C07.320.610.291	Craniomandibular Disorders	Diseases or disorders of the muscles of the head and neck, with special reference to the masticatory muscles. The most notable examples are TEMPOROMANDIBULAR JOINT DISORDERS and TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME.	""	0	#FFFFFF
D017282	C01.920.930	Tick-Borne Diseases	Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic.	""	0	#FFFFFF
D017285	C05.651.594.819|C10.668.491.562.575	Polymyositis	Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)	""	0	#FFFFFF
D017359	C12.050.703.395.186	HELLP Syndrome	A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.	""	0	#FFFFFF
D017379	C14.280.195.400|C23.300.775.250.400	Hypertrophy, Left Ventricular	Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.	""	0	#FFFFFF
D017380	C14.280.195.410|C23.300.775.250.401	Hypertrophy, Right Ventricular	Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality.	""	0	#FFFFFF
D017436	C12.050.351.875.253.096.750|C12.200.706.316.096.750|C12.800.316.096.750|C16.131.939.316.096.750|C16.320.467|C19.391.119.096.750|C19.391.482.600	Kallmann Syndrome	A genetically heterogeneous disorder caused by hypothalamic GNRH deficiency and OLFACTORY NERVE defects. It is characterized by congenital HYPOGONADOTROPIC HYPOGONADISM and ANOSMIA, possibly with additional midline defects. It can be transmitted as an X-linked (GENETIC DISEASES, X-LINKED), an autosomal dominant, or an autosomal recessive trait.	""	0	#FFFFFF
D017437	C17	Skin and Connective Tissue Diseases	A collective term for diseases of the skin and its appendages and of connective tissue.	""	0	#FFFFFF
D017439	C23.550.355.274.505	Cicatrix, Hypertrophic	An elevated scar, resembling a KELOID, but which does not spread into surrounding tissues. It is formed by enlargement and overgrowth of cicatricial tissue and regresses spontaneously.	""	0	#FFFFFF
D017441	C17.300.200.495|C17.800.550	Necrobiotic Disorders	A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis.	""	0	#FFFFFF
D017443	C17.800.815	Skin Diseases, Eczematous	Any of a variety of eruptive skin disorders characterized by erythema, oozing, vesiculation, and scaling. Etiology is varied.	""	0	#FFFFFF
D017444	C17.800.859	Skin Diseases, Papulosquamous	A group of dermatoses with distinct morphologic features. The primary lesion is most commonly a papule, usually erythematous, with a variable degree of scaling on the surface. Plaques form through the coalescing of primary lesions.	""	0	#FFFFFF
D017445	C17.800.862	Skin Diseases, Vascular	Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.	""	0	#FFFFFF
D017449	C17.800.174.255.100|C17.800.815.255.100|C20.543.418.150	Dermatitis, Allergic Contact	A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	""	0	#FFFFFF
D017453	C17.800.174.255.400|C17.800.815.255.400	Dermatitis, Irritant	A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.	""	0	#FFFFFF
D017454	C17.800.174.255.100.600|C17.800.600.325|C17.800.815.255.100.600|C20.543.418.150.600	Dermatitis, Photoallergic	A delayed hypersensitivity involving the reaction between sunlight or other radiant energy source and a chemical substance to which the individual has been previously exposed and sensitized. It manifests as a papulovesicular, eczematous, or exudative dermatitis occurring chiefly on the light-exposed areas of the skin.	""	0	#FFFFFF
D017484	C17.800.174.255.400.225|C17.800.600.335|C17.800.815.255.400.225	Dermatitis, Phototoxic	A nonimmunologic, chemically induced type of photosensitivity producing a sometimes vesiculating dermatitis. It results in hyperpigmentation and desquamation of the light-exposed areas of the skin.	""	0	#FFFFFF
D017486	C17.800.030	Acneiform Eruptions	Visible efflorescent lesions of the skin caused by acne or resembling acne. (Dorland, 28th ed, p18, 575)	""	0	#FFFFFF
D017488	C16.131.831.512.400.375|C16.320.850.400.375|C16.614.492.400.375|C17.800.428.333.250.375|C17.800.804.512.400.375|C17.800.827.400.375	Hyperkeratosis, Epidermolytic	A form of congenital ichthyosis inherited as an autosomal dominant trait and characterized by ERYTHRODERMA and severe hyperkeratosis. It is manifested at birth by blisters followed by the appearance of thickened, horny, verruciform scales over the entire body, but accentuated in flexural areas. Mutations in the genes that encode KERATIN-1 and KERATIN-10 have been associated with this disorder.	""	0	#FFFFFF
D017490	C16.131.831.512.400.410|C16.320.850.400.410|C16.614.492.400.410|C17.800.428.333.250.410|C17.800.804.512.400.410|C17.800.827.400.410	Ichthyosis, Lamellar	A chronic, congenital ichthyosis inherited as an autosomal recessive trait. Infants are usually born encased in a collodion membrane which sheds within a few weeks. Scaling is generalized and marked with grayish-brown quadrilateral scales, adherent at their centers and free at the edges. In some cases, scales are so thick that they resemble armored plate.	""	0	#FFFFFF
D017492	C17.800.428.580	Keratosis, Seborrheic	Benign eccrine poromas that present as multiple oval, brown-to-black plaques, located mostly on the chest and back. The age of onset is usually in the fourth or fifth decade.	""	0	#FFFFFF
D017495	C17.800.621.430	Hyperpigmentation	Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.	""	0	#FFFFFF
D017496	C17.800.621.440	Hypopigmentation	A condition caused by a deficiency or a loss of melanin pigmentation in the epidermis, also known as hypomelanosis. Hypopigmentation can be localized or generalized, and may result from genetic defects, trauma, inflammation, or infections.	""	0	#FFFFFF
D017497	C01.150.252.819.420|C01.800.720.420|C01.830.499|C17.800.838.765.420|C17.800.946.315.320	Hidradenitis Suppurativa	A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.	""	0	#FFFFFF
D017499	C16.320.850.730|C17.800.428.750|C17.800.827.730	Porokeratosis	A heritable disorder of faulty keratinization characterized by the proliferation of abnormal clones of KERATINOCYTES and lesions showing varying atrophic patches surrounded by an elevated, keratotic border. These keratotic lesions can progress to overt cutaneous neoplasm. Several clinical variants are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis.	""	0	#FFFFFF
D017511	C17.800.695.675|C17.800.862.675|C17.800.893.675	Pyoderma Gangrenosum	An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.	""	0	#FFFFFF
D017512	C17.800.859.475	Lichenoid Eruptions	Conditions in which there is histological damage to the lower epidermis along with a grouped chronic inflammatory infiltrate in the papillary dermis disturbing the interface between the epidermis and dermis. LICHEN PLANUS is the prototype of all lichenoid eruptions. (From Rook et al., Textbook of Dermatology, 4th ed, p398)	""	0	#FFFFFF
D017513	C17.800.859.475.545	Lichen Nitidus	A chronic inflammatory disease characterized by shiny, flat-topped, usually flesh-colored micropapules no larger than the head of a pin. Lesions are localized in the early stages, found chiefly on the lower abdomen, penis, and inner surface of the thighs. Distribution may become generalized as the disease progresses.	""	0	#FFFFFF
D017514	C17.800.859.475.650|C17.800.859.575.650|C17.800.859.600.650	Pityriasis Lichenoides	A subgroup of PARAPSORIASIS itself divided into acute and chronic forms. The acute form is characterized by the abrupt onset of a generalized, reddish-brown, maculopapular eruption. Lesions may be vesicular, hemorrhagic, crusted, or necrotic. Histologically the disease is characterized by epidermal necrolysis. The chronic form shows milder skin changes with necrosis.	""	0	#FFFFFF
D017515	C17.800.859.600.675	Pityriasis Rosea	A mild exanthematous inflammation of unknown etiology. It is characterized by the presence of salmon-colored maculopapular lesions. The most striking feature is the arrangement of the lesions such that the long axis is parallel to the lines of cleavage. The eruptions are usually generalized, affecting chiefly the trunk, and the course is often self-limiting.	""	0	#FFFFFF
D017520	C17.300.550	Mucinoses	Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.	""	0	#FFFFFF
D017541	C14.907.055.090	Aneurysm, False	Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.	""	0	#FFFFFF
D017542	C14.907.055.185	Aneurysm, Ruptured	The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.	""	0	#FFFFFF
D017543	C14.907.055.625	Iliac Aneurysm	Abnormal balloon- or sac-like dilatation in the wall of any one of the iliac arteries including the common, the internal, or the external ILIAC ARTERY.	""	0	#FFFFFF
D017544	C14.907.055.239.075|C14.907.109.139.075	Aortic Aneurysm, Abdominal	An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.	""	0	#FFFFFF
D017545	C14.907.055.239.125|C14.907.109.139.125	Aortic Aneurysm, Thoracic	An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.	""	0	#FFFFFF
D017562	C06.130.825|C23.550.767.775	Postcholecystectomy Syndrome	Abdominal symptoms after removal of the GALLBLADDER. The common postoperative symptoms are often the same as those present before the operation, such as COLIC, bloating, NAUSEA, and VOMITING. There is pain on palpation of the right upper quadrant and sometimes JAUNDICE. The term is often used, inaccurately, to describe such postoperative symptoms not due to gallbladder removal.	""	0	#FFFFFF
D017563	C08.381.483	Lung Diseases, Interstitial	A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.	""	0	#FFFFFF
D017564	C08.381.483.675|C08.381.520.734|C26.733.762	Radiation Pneumonitis	Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.	""	0	#FFFFFF
D017565	C08.381.483.725|C15.604.515.827.725	Sarcoidosis, Pulmonary	Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)	""	0	#FFFFFF
D017566	C14.280.647.187.575|C14.907.585.187.575	Microvascular Angina	ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.	""	0	#FFFFFF
D017573	C07.465.342	Focal Epithelial Hyperplasia	Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, presenting soft, painless, round to oval sessile papules about 1 to 4 mm in diameter. The condition usually occurs in children and young adults and has familial predilection, lasting for several months, sometimes years, before running its course. A viral etiology is suspected, the isolated organism being usually the human papillomavirus. (Jablonski, Illustrated Dictionary of Dentistry; Belshe, Textbook of Human Virology, 2d ed, p954)	""	0	#FFFFFF
D017574	C14.280.067.672|C23.550.073.670	Parasystole	A cardiac arrhythmia that is caused by interaction of two independently initiated cardiac impulses of different rates from two separate foci. Generally one focus is the SINOATRIAL NODE, the normal pacemaker. The ectopic focus is usually in the HEART VENTRICLE but can be in the HEART ATRIUM or the ATRIOVENTRICULAR NODE. Modulation of the parasystolic rhythm by the sinus rhythm depends on the completeness of entrance block surrounding the parasystolic focus.	""	0	#FFFFFF
D017577	C17.800.135|C23.300.575.150	Cutaneous Fistula	An abnormal passage or communication leading from an internal organ to the surface of the body.	""	0	#FFFFFF
D017588	C12.050.351.875.253.064.500|C12.050.351.875.253.090.750|C12.200.706.316.064.500|C12.200.706.316.090.750|C12.800.316.064.500|C12.800.316.090.750|C16.131.939.316.064.500|C16.131.939.316.129.750|C19.391.119.064.500|C19.391.119.090.750	Hyperandrogenism	A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.	""	0	#FFFFFF
D017590	C10.228.140.163.560|C10.314.500|C18.452.132.560	Myelinolysis, Central Pontine	A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)	""	0	#FFFFFF
D017593	C10.886.425.800.200.500	Kleine-Levin Syndrome	A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)	""	0	#FFFFFF
D017599	C04.557.465.625|C04.557.580.625	Neuroectodermal Tumors	Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.	""	0	#FFFFFF
D017600	C04.557.465.625.630|C04.557.580.625.630	Neuroectodermal Tumor, Melanotic	A benign, rapidly growing, deeply pigmented tumor of the jaw and occasionally of other sites, consisting of an infiltrating mass of cells arranged in an alveolar pattern, and occurring almost exclusively in infants. Its source of origin is in dispute, the various theories giving rise to its several names. (Dorland, 27th ed)	""	0	#FFFFFF
D017622	C07.465.714.354.750	Periodontal Attachment Loss	Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.	""	0	#FFFFFF
D017624	C04.557.435.595.950|C04.588.945.947.535.585.950|C04.700.900.950|C10.597.606.360.969|C11.250.060.950|C11.270.060.950|C11.941.375.060.950|C12.050.351.875.253.096.875|C12.050.351.937.820.535.585.950|C12.050.351.968.419.473.585.950|C12.200.706.316.096.875|C12.200.758.820.750.585.950|C12.200.777.419.473.585.950|C12.800.316.096.875|C12.900.820.535.585.950|C12.950.419.473.585.950|C12.950.983.535.585.950|C16.131.260.940|C16.131.384.079.950|C16.131.939.316.096.875|C16.320.180.940|C16.320.290.078.950|C16.320.700.900.950|C19.391.119.096.875	WAGR Syndrome	A contiguous gene syndrome associated with hemizygous deletions of chromosome region 11p13. The condition is marked by the combination of WILMS TUMOR; ANIRIDIA; GENITOURINARY ABNORMALITIES; and INTELLECTUAL DISABILITY.	""	0	#FFFFFF
D017674	C18.452.750.400	Hypophosphatemia	A condition of an abnormally low level of PHOSPHATES in the blood.	""	0	#FFFFFF
D017675	C06.405.117.119.500.204|C14.907.617.812.500|C14.907.823.225|C17.300.799.801.500|C17.800.784.801.500|C18.452.174.130.204	CREST Syndrome	A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.	""	0	#FFFFFF
D017676	C07.465.397|C17.800.859.475.560.397	Lichen Planus, Oral	Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)	""	0	#FFFFFF
D017681	C15.378.553.231.549	Hypereosinophilic Syndrome	A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.	""	0	#FFFFFF
D017682	C14.280.671|C23.888.582	Myocardial Stunning	Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.	""	0	#FFFFFF
D017688	C06.405.205.200	Cholera Morbus	An old term that is no longer used in the scientific literature. Cholera morbus refers to acute GASTROENTERITIS occurring in summer or autumn; characterized by severe cramps, diarrhea, and vomiting.	""	0	#FFFFFF
D017689	C05.660.585.600|C16.131.621.585.600	Polydactyly	A congenital anomaly of the hand or foot, marked by the presence of supernumerary digits.	""	0	#FFFFFF
D017695	C26.808	Soft Tissue Injuries	"Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera. It is meaningful with reference to regions or organs where soft tissue (muscle, fat, skin) should be differentiated from bones or bone tissue, as ""soft tissue injuries of the hand""."	""	0	#FFFFFF
D017696	C05.651.575.290|C10.668.491.550.290	Myopathies, Nemaline	A group of inherited congenital myopathic conditions characterized clinically by weakness, hypotonia, and prominent hypoplasia of proximal muscles including the face. Muscle biopsy reveals large numbers of rod-shaped structures beneath the muscle fiber plasma membrane. This disorder is genetically heterogeneous and may occasionally present in adults. (Adams et al., Principles of Neurology, 6th ed, p1453)	""	0	#FFFFFF
D017699	C23.888.592.612.944	Pelvic Pain	Pain in the pelvic region of genital and non-genital origin.	""	0	#FFFFFF
D017700	C14.907.355.350.454.500	Embolism, Cholesterol	Blocking of a blood vessel by CHOLESTEROL-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.	""	0	#FFFFFF
D017703	C01.748.561.625|C01.830.025.780|C07.550.781.625|C08.730.561.625|C09.775.649.625	Retropharyngeal Abscess	An accumulation of purulent material in the space between the PHARYNX and the CERVICAL VERTEBRAE. This usually results from SUPPURATION of retropharyngeal LYMPH NODES in patients with UPPER RESPIRATORY TRACT INFECTIONS, perforation of the pharynx, or head and neck injuries.	""	0	#FFFFFF
D017714	C01.234	Community-Acquired Infections	Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.	""	0	#FFFFFF
D017719	C14.907.320.191|C17.800.893.592.450.200|C19.246.099.500.191|C19.246.099.937.250	Diabetic Foot	Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.	""	0	#FFFFFF
D017726	C01.375.725.270|C01.925.256.466.245.150|C01.925.325.270|C11.294.800.270|C11.768.773.360	Cytomegalovirus Retinitis	Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.	""	0	#FFFFFF
D017728	C04.557.386.480.750.399|C15.604.515.569.480.750.600|C20.683.515.761.480.750.399	Lymphoma, Large-Cell, Anaplastic	"A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called ""hallmark"" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS."	""	0	#FFFFFF
D017731	C04.557.386.480.750.800.528|C15.604.515.569.480.750.800.528|C20.683.515.761.480.750.800.528	Lymphomatoid Papulosis	Clinically benign, histologically malignant, recurrent cutaneous T-cell lymphoproliferative disorder characterized by an infiltration of large atypical cells surrounded by inflammatory cells. The atypical cells resemble REED-STERNBERG CELLS of HODGKIN DISEASE or the malignant cells of CUTANEOUS T-CELL LYMPHOMA. In some cases, lymphomatoid papulosis progresses to lymphomatous conditions including MYCOSIS FUNGOIDES; HODGKIN DISEASE; CUTANEOUS T-CELL LYMPHOMA; or ANAPLASTIC LARGE-CELL LYMPHOMA.	""	0	#FFFFFF
D017733	C01.925.256.466.313.500|C04.588.443.591.545.500|C04.834.512.513.500|C07.465.530.545.500|C23.300.816.513.500	Leukoplakia, Hairy	Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.	""	0	#FFFFFF
D017759	C26.404.249	Fractures, Malunited	Union of the fragments of a fractured bone in a faulty or abnormal position. If two bones parallel to one another unite by osseous tissue, the result is a crossunion. (From Manual of Orthopaedic Terminology, 4th ed)	""	0	#FFFFFF
D017760	C05.116.214	Bone Malalignment	Displacement of bones out of line in relation to joints. It may be congenital or traumatic in origin.	""	0	#FFFFFF
D017769	C10.668.829.500.850.600|C10.668.829.550.925|C26.844.150.957	Ulnar Nerve Compression Syndromes	Ulnar neuropathies caused by mechanical compression of the nerve at any location from its origin at the BRACHIAL PLEXUS to its terminations in the hand. Common sites of compression include the retroepicondylar groove, cubital tunnel at the elbow (CUBITAL TUNNEL SYNDROME), and Guyon's canal at the wrist. Clinical features depend on the site of injury, but may include weakness or paralysis of wrist flexion, finger flexion, and ulnar innervated intrinsic hand muscles, and impaired sensation over the ulnar aspect of the hand, fifth finger, and ulnar half of the ring finger. (Joynt, Clinical Neurology, 1995, Ch51, p43)	""	0	#FFFFFF
D017772	C10.668.829.050|C18.452.845.500.050	Amyloid Neuropathies	Disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. Familial, primary (nonfamilial), and secondary forms have been described. Some familial subtypes demonstrate an autosomal dominant pattern of inheritance. Clinical manifestations include sensory loss, mild weakness, autonomic dysfunction, and CARPAL TUNNEL SYNDROME. (Adams et al., Principles of Neurology, 6th ed, p1349)	""	0	#FFFFFF
D017789	C23.550.382.937	Granuloma, Pyogenic	A disorder of the skin, the oral mucosa, and the gingiva, that usually presents as a solitary polypoid capillary hemangioma often resulting from trauma. It is manifested as an inflammatory response with similar characteristics to those of a granuloma.	""	0	#FFFFFF
D017823	C07.465.714.204	Furcation Defects	Conditions in which a bifurcation or trifurcation of the molar tooth root becomes denuded as a result of periodontal disease. It may be followed by tooth mobility, temperature sensitivity, pain, and alveolar bone resorption.	""	0	#FFFFFF
D017824	C04.182.089.265|C05.116.070.265	Bone Cysts, Aneurysmal	Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.	""	0	#FFFFFF
D017825	C10.228.140.163.100.362.375|C10.228.140.695.625.375|C10.314.400.375|C10.574.500.300|C16.320.400.150|C16.320.565.189.362.375|C18.452.132.100.362.375|C18.452.648.189.362.375	Canavan Disease	A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)	""	0	#FFFFFF
D017827	C10.228.140.252.190.530.530|C10.228.140.252.700.700.500|C10.228.854.787.875.500|C10.574.500.825.700.500|C10.597.350.090.500.530.530|C16.320.400.780.875.500	Machado-Joseph Disease	A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)	""	0	#FFFFFF
D017880	C05.660.585|C16.131.621.585	Limb Deformities, Congenital	Congenital structural deformities of the upper and lower extremities collectively or unspecified.	""	0	#FFFFFF
D017887	C05.116.900.480|C23.550.751.500	Ossification of Posterior Longitudinal Ligament	A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. It is often associated with anterior ankylosing hyperostosis.	""	0	#FFFFFF
D017889	C11.941.375.285	Exfoliation Syndrome	The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)	""	0	#FFFFFF
D017890	C15.604.744.742.500|C26.017.680.500|C26.761.555.500	Splenosis	The spontaneous transplantation of splenic tissue to unusual sites after open splenic trauma, e.g., after automobile accidents, gunshot or stab wounds. The splenic pulp implants appear as red-blue nodules on the peritoneum, omentum, and mesentery, morphologically similar to multifocal pelvic endometriosis. (Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D018058	C09.218.903|C26.930	Tympanic Membrane Perforation	A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.	""	0	#FFFFFF
D018088	C01.150.252.410.040.552.846.775	Tuberculosis, Multidrug-Resistant	Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.	""	0	#FFFFFF
D018126	C07.650.800.600|C07.793.700.600|C16.131.850.800.600	Odontodysplasia	A localized arrested tooth development which appears to involve most commonly the anterior teeth, usually on one side of the midline, most often the maxillary central and lateral incisors. Roentgenographically, the teeth have a ghostlike appearance. Calcification and bits of prismatic enamel may be found in the pulp and the enamel is thin and absent in part. (Jablonski, Illustrated Dictionary of Dentistry, 1982)	""	0	#FFFFFF
D018149	C18.452.394.952.500	Glucose Intolerance	A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.	""	0	#FFFFFF
D018159	C09.218.568.217	Endolymphatic Hydrops	An accumulation of ENDOLYMPH in the inner ear (LABYRINTH) leading to buildup of pressure and distortion of intralabyrinthine structures, such as COCHLEA and SEMICIRCULAR CANALS. It is characterized by SENSORINEURAL HEARING LOSS; TINNITUS; and sometimes VERTIGO.	""	0	#FFFFFF
D018173	C01.925.256.200	Circoviridae Infections	Virus diseases caused by the CIRCOVIRIDAE.	""	0	#FFFFFF
D018174	C01.925.782.600.100	Arterivirus Infections	Infections caused by viruses of the genus ARTERIVIRUS.	""	0	#FFFFFF
D018175	C01.925.782.123	Birnaviridae Infections	Virus diseases caused by the BIRNAVIRIDAE.	""	0	#FFFFFF
D018176	C01.925.782.600.550.800	Torovirus Infections	Infections with viruses of the genus TOROVIRUS, family CORONAVIRIDAE.	""	0	#FFFFFF
D018177	C01.925.782.350.250	Flavivirus Infections	Infections with viruses of the genus FLAVIVIRUS, family FLAVIVIRIDAE.	""	0	#FFFFFF
D018178	C01.925.782.350	Flaviviridae Infections	Infections with viruses of the family FLAVIVIRIDAE.	""	0	#FFFFFF
D018182	C01.925.782.350.675	Pestivirus Infections	Infections with viruses of the genus PESTIVIRUS, family FLAVIVIRIDAE.	""	0	#FFFFFF
D018184	C01.925.782.580.600	Paramyxoviridae Infections	Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.	""	0	#FFFFFF
D018185	C01.925.782.580.600.500	Morbillivirus Infections	Infections with viruses of the genus MORBILLIVIRUS, family PARAMYXOVIRIDAE. Infections mainly cause acute disease in their hosts, although in some cases infection is persistent and leads to degenerative conditions.	""	0	#FFFFFF
D018186	C01.925.782.580.600.550	Pneumovirus Infections	Infections with viruses of the genus PNEUMOVIRUS, family PARAMYXOVIRIDAE. This includes RESPIRATORY SYNCYTIAL VIRUS INFECTIONS, an important cause of respiratory disease in humans.	""	0	#FFFFFF
D018188	C01.925.782.687.150	Cardiovirus Infections	Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.	""	0	#FFFFFF
D018190	C04.557.375	Lymphatic Vessel Tumors	Neoplasms composed of lymphoid tissue, a lattice work of reticular tissue the interspaces of which contain lymphocytes. The concept does not refer to neoplasms located in lymphatic vessels.	""	0	#FFFFFF
D018191	C04.557.375.450.450	Lymphangioma, Cystic	A cystic growth originating from lymphatic tissue. It is usually found in the neck, axilla, or groin.	""	0	#FFFFFF
D018192	C04.557.375.460.465|C04.557.450.692.500|C15.604.515.562.465|C20.683.515.710.465	Lymphangioleiomyomatosis	A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).	""	0	#FFFFFF
D018193	C04.557.435	Neoplasms, Complex and Mixed	Neoplasms composed of more than one type of neoplastic tissue.	""	0	#FFFFFF
D018194	C04.557.435.110	Adenomyoma	A benign neoplasm of muscle (usually smooth muscle) with glandular elements. It occurs most frequently in the uterus and uterine ligaments. (Stedman, 25th ed)	""	0	#FFFFFF
D018195	C04.557.435.135|C04.557.450.795.135	Adenosarcoma	A malignant neoplasm arising simultaneously or consecutively in mesodermal tissue and glandular epithelium of the same part. (Stedman, 25th ed)	""	0	#FFFFFF
D018196	C04.557.435.250|C04.557.470.200.150	Carcinoma, Adenosquamous	A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.	""	0	#FFFFFF
D018197	C04.557.435.380	Hepatoblastoma	A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)	""	0	#FFFFFF
D018198	C04.557.435.525	Mixed Tumor, Malignant	A malignant tumor composed of more than one type of neoplastic tissue. (Dorland, 27th ed)	""	0	#FFFFFF
D018199	C04.557.435.530|C04.557.450.795.530	Mixed Tumor, Mesodermal	A sarcoma of the body of the uterus arising in older women, composed of more than one mesenchymal tissue, especially including striated muscle cells. It is associated with previous pelvic radiation exposure in 20% of patients. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1702)	""	0	#FFFFFF
D018200	C04.557.435.540	Mixed Tumor, Mullerian	A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)	""	0	#FFFFFF
D018201	C04.557.435.600|C04.588.945.947.535.790|C12.050.351.937.820.535.790|C12.050.351.968.419.473.372|C12.200.758.820.750.372|C12.200.777.419.473.372|C12.900.820.535.790|C12.950.419.473.372|C12.950.983.535.790	Nephroma, Mesoblastic	A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.	""	0	#FFFFFF
D018202	C04.557.435.675|C04.588.894.797.520.867	Pulmonary Blastoma	A malignant neoplasm of the lung composed chiefly or entirely of immature undifferentiated cells (i.e., blast forms) with little or virtually no stroma. (From Stedman, 25th ed)	""	0	#FFFFFF
D018203	C04.557.435.775|C04.557.450.795.332.500|C12.050.351.500.852.762.200.500.500|C12.050.351.937.418.875.200.374.500|C12.100.250.852.762.200.500.500|C12.900.418.875.200.374.500	Sarcoma, Endometrial Stromal	A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).	""	0	#FFFFFF
D018204	C04.557.450	Neoplasms, Connective and Soft Tissue	Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.	""	0	#FFFFFF
D018205	C04.557.450.550	Neoplasms, Adipose Tissue	Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.	""	0	#FFFFFF
D018206	C04.557.450.550.100	Angiolipoma	A benign neoplasm composed of a mixture of adipose tissue and blood vessels. (Dorland, 27th ed)	""	0	#FFFFFF
D018207	C04.557.450.550.125|C04.557.450.692.249	Angiomyolipoma	A benign tumor containing vascular, adipose, and muscle elements. It occurs most often in the kidney with smooth muscle elements (angiolipoleiomyoma) in association with tuberous sclerosis. (Dorland, 27th ed)	""	0	#FFFFFF
D018208	C04.557.450.550.420.425|C04.557.450.795.465.425	Liposarcoma, Myxoid	A liposarcoma containing round mesenchymal cells and a myxoid extracellular matrix in stroma.	""	0	#FFFFFF
D018209	C04.557.450.550.710	Myelolipoma	A rare benign tumor of the adrenal gland, several centimeters in diameter, composed in varying proportions of adipose tissue, lymphocytes, and primitive myeloid cells, probably a developmental abnormality. (Dorland, 27th ed)	""	0	#FFFFFF
D018210	C04.557.450.565.265.270	Chondromatosis	Multiple formation of chondromas. (Dorland, 27th ed)	""	0	#FFFFFF
D018211	C04.557.450.565.280.280|C04.557.450.795.300.280	Chondrosarcoma, Mesenchymal	A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)	""	0	#FFFFFF
D018212	C04.557.450.565.380.380|C04.557.450.565.575.420	Giant Cell Tumor of Bone	A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)	""	0	#FFFFFF
D018213	C04.557.450.565.575	Neoplasms, Bone Tissue	Neoplasms composed of bony tissue, whether normal or of a soft tissue which has become ossified. The concept does not refer to neoplasms located in bones.	""	0	#FFFFFF
D018214	C04.557.450.565.575.400|C04.557.450.565.590.340.360	Fibroma, Ossifying	A benign central bone tumor, usually of the jaws (especially the mandible), composed of fibrous connective tissue within which bone is formed.	""	0	#FFFFFF
D018215	C04.557.450.565.575.600	Osteoblastoma	A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue. It occurs frequently in the spine of young persons. (From Dorland, 27th ed; Stedman, 25th ed)	""	0	#FFFFFF
D018216	C04.557.450.565.575.610.615|C05.116.099.708.670.615	Osteochondromatosis	A condition marked by the presence of multiple osteochondromas. (Dorland, 27th ed)	""	0	#FFFFFF
D018217	C04.557.450.565.575.650.655|C04.557.450.795.620.655	Osteosarcoma, Juxtacortical	A form of osteogenic sarcoma of relatively low malignancy, probably arising from the periosteum and initially involving cortical bone and adjacent connective tissue. It occurs in middle-aged as well as young adults and most commonly affects the lower part of the femoral shaft. (Stedman, 25th ed)	""	0	#FFFFFF
D018218	C04.557.450.565.590	Neoplasms, Fibrous Tissue	Neoplasms composed of fibrous tissue, the ordinary connective tissue of the body, made up largely of yellow or white fibers. The concept does not refer to neoplasms located in fibrous tissue.	""	0	#FFFFFF
D018219	C04.557.450.565.590.425.350	Histiocytoma, Benign Fibrous	A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)	""	0	#FFFFFF
D018220	C04.557.450.565.590.340.345	Fibroma, Desmoplastic	An extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. It appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1441)	""	0	#FFFFFF
D018221	C04.557.450.565.590.340.400	Fibromatosis, Abdominal	A relatively large mass of unusually firm scarlike connective tissue resulting from active participation of fibroblasts, occurring most frequently in the abdominal muscles of women who have borne children. The fibroblasts infiltrate surrounding muscle and fascia. (Stedman, 25th ed)	""	0	#FFFFFF
D018222	C04.557.450.565.590.340.410	Fibromatosis, Aggressive	A childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL. (Stedman, 25th ed)	""	0	#FFFFFF
D018223	C04.557.450.565.590.350.320|C04.557.450.795.350.320	Dermatofibrosarcoma	A sarcoma of the deep layers of the skin. The tumors are locally aggressive tends to recur but rarely metastatic. It can be classified into variants depending on the cell type tumors are derived from or by its characteristics: Pigmented variant from MELANIN-containing DERMAL DENDRITIC CELLS; Myxoid variant, myxoid STROMAL CELLS; Giant cell variant characterized by GIANT CELLS in the tumors; and Fibrosarcomatous variant chracterized by tumor areas histologically indistinguishable from FIBROSARCOMA.	""	0	#FFFFFF
D018224	C04.557.450.565.590.550	Myofibromatosis	A condition characterized by multiple formations of myofibromas (LEIOMYOMA).	""	0	#FFFFFF
D018225	C04.557.450.565.590.595|C04.557.470.625	Neoplasms, Fibroepithelial	Neoplasms composed of fibrous and epithelial tissue. The concept does not refer to neoplasms located in fibrous tissue or epithelium.	""	0	#FFFFFF
D018226	C04.557.450.565.590.595.350|C04.557.470.625.350	Fibroadenoma	An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)	""	0	#FFFFFF
D018227	C04.557.450.565.800|C04.557.450.795.800	Sarcoma, Clear Cell	A sarcoma of young adults occurring in the lower extremities and acral regions. It is found intimately bound to tendons as a circumscribed but unencapsulated melanin-bearing tumor of neuroectodermal origin. Clear cell sarcoma is associated with a specific t(12;22)(q13;q12) translocation.	""	0	#FFFFFF
D018228	C04.557.450.565.825|C04.557.450.795.870	Sarcoma, Small Cell	A sarcoma characterized by the presence of small cells, cells measuring 9-14 micrometers with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. (From Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D018229	C04.557.450.590.450.125	Angiomyoma	A benign tumor consisting of vascular and smooth muscle elements.	""	0	#FFFFFF
D018230	C04.557.450.590.450.455	Leiomyoma, Epithelioid	A relatively rare smooth muscle tumor found most frequently in the wall of the gastrointestinal tract, especially in the stomach. It is similar to other smooth muscle tumors but may become very large and hemorrhage and exhibit small cystic areas. Simple excision is almost always curative. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1354)	""	0	#FFFFFF
D018231	C04.557.450.590.450.465	Leiomyomatosis	The state of having multiple leiomyomas throughout the body. (Stedman, 25th ed)	""	0	#FFFFFF
D018232	C04.557.450.590.550.660.665|C04.557.450.795.550.660.665	Rhabdomyosarcoma, Alveolar	"A form of RHABDOMYOSARCOMA occurring mainly in adolescents and young adults, affecting muscles of the extremities, trunk, orbital region, etc. It is extremely malignant, metastasizing widely at an early stage. Few cures have been achieved and the prognosis is poor. ""Alveolar"" refers to its microscopic appearance simulating the cells of the respiratory alveolus. (Holland et al., Cancer Medicine, 3d ed, p2188)"	""	0	#FFFFFF
D018233	C04.557.450.590.550.660.675|C04.557.450.795.550.660.675	Rhabdomyosarcoma, Embryonal	A form of RHABDOMYOSARCOMA arising primarily in the head and neck, especially the orbit, of children below the age of 10. The cells are smaller than those of other rhabdomyosarcomas and are of two basic cell types: spindle cells and round cells. This cancer is highly sensitive to chemotherapy and has a high cure rate with multi-modality therapy. (From Holland et al., Cancer Medicine, 3d ed, p2188)	""	0	#FFFFFF
D018234	C04.557.450.590.775|C04.557.450.795.775	Sarcoma, Alveolar Soft Part	A variety of rare sarcoma having a reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue. It is a rare tumor, usually occurring between 15 and 35 years of age. It appears in the muscles of the extremities in adults and most commonly in the head and neck regions of children. Though slow-growing, it commonly metastasizes to the lungs, brain, bones, and lymph nodes. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1365)	""	0	#FFFFFF
D018235	C04.557.450.590.800	Smooth Muscle Tumor	A tumor composed of smooth muscle tissue, as opposed to leiomyoma, a tumor derived from smooth muscle.	""	0	#FFFFFF
D018236	C04.557.465.200	Carcinoma, Embryonal	A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)	""	0	#FFFFFF
D018237	C04.557.465.330	Germinoma	A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)	""	0	#FFFFFF
D018238	C04.557.465.420|C04.557.475.395|C12.050.351.875.253.096.687.500|C12.050.351.875.253.309.388.500|C12.200.706.316.096.687.500|C12.200.706.316.309.388.500|C12.800.316.096.687.500|C12.800.316.309.388.500|C16.131.939.316.096.687.500|C16.131.939.316.309.388.500|C19.391.119.096.687.500|C19.391.119.309.388.500	Gonadoblastoma	A complex neoplasm composed of a mixture of gonadal elements, such as large primordial GERM CELLS, immature SERTOLI CELLS or GRANULOSA CELLS of the sex cord, and gonadal stromal cells. Gonadoblastomas are most often associated with gonadal dysgenesis, 46, XY.	""	0	#FFFFFF
D018239	C04.557.465.330.800	Seminoma	A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)	""	0	#FFFFFF
D018240	C04.557.465.510.350	Endodermal Sinus Tumor	An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)	""	0	#FFFFFF
D018241	C04.557.465.625.600.590.650|C04.557.470.670.590.650|C04.557.580.625.600.590.650	Neuroectodermal Tumors, Primitive, Peripheral	A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.	""	0	#FFFFFF
D018242	C04.557.465.625.600.590|C04.557.470.670.590|C04.557.580.625.600.590	Neuroectodermal Tumors, Primitive	A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)	""	0	#FFFFFF
D018243	C04.557.465.900	Teratocarcinoma	A malignant neoplasm consisting of elements of teratoma with those of embryonal carcinoma or choriocarcinoma, or both. It occurs most often in the testis. (Dorland, 27th ed)	""	0	#FFFFFF
D018245	C04.557.465.955.207.875|C04.557.470.200.025.455.875|C04.850.908.208.875|C12.050.703.720.949.208.875	Trophoblastic Tumor, Placental Site	An uncommon variant of CHORIOCARCINOMA. It is composed almost entirely of mononuclear cytotrophoblasts (TROPHOBLASTS). Because its secretion of hCG (CHORIONIC GONADOTROPIN) is low, a large tumor may develop before the hCG can be detected.	""	0	#FFFFFF
D018246	C04.588.322.078.265.500|C19.053.098.265.500|C19.053.347.500.500|C19.344.078.265.500	Adrenocortical Adenoma	A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.	""	0	#FFFFFF
D018248	C04.557.470.035.120|C04.588.274.623.040|C06.301.623.040|C06.552.697.040	Adenoma, Liver Cell	A benign epithelial tumor of the LIVER.	""	0	#FFFFFF
D018249	C04.557.470.035.140	Adenoma, Oxyphilic	A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.	""	0	#FFFFFF
D018250	C04.557.470.035.175.125|C04.557.470.550.175.125	Acrospiroma	A rare cutaneous tumor of apocrine or eccrine SWEAT GLAND origin. It is most commonly found on the extremities and is usually benign. It appears as a solitary nodule or cyst and may be solid or produce a watery discharge. It is related to POROMA except in acrospiroma it does not involve the epidermis. There is no indication that heredity or external agents cause these tumors.	""	0	#FFFFFF
D018251	C04.557.470.035.175.375|C04.557.470.550.175.375	Hidrocystoma	A cystic form of sweat gland adenoma (ADENOMA, SWEAT GLAND). It is produced by the cystic proliferation of apocrine secretory glands. It is not uncommon, occurring in adult life in no particular age group, with males and females equally affected. The commonest site is around the eye, particularly lateral to the outer canthus. It is cured by surgical removal. (Stedman, 25th ed; Rook et al., Textbook of Dermatology, 4th ed, p2410)	""	0	#FFFFFF
D018252	C04.557.470.035.175.800|C04.557.470.550.175.800	Syringoma	A benign tumor of the sweat glands which is usually multiple and results from malformation of sweat ducts. It is uncommon and more common in females than in males. It is most likely to appear at adolescence, and further lesions may develop during adult life. It does not appear to be hereditary. (Rook et al., Textbook of Dermatology, 4th ed, pp2407-8)	""	0	#FFFFFF
D018253	C04.557.470.035.185	Adenoma, Villous	An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)	""	0	#FFFFFF
D018254	C04.557.470.035.200|C04.557.470.660.200	Adenomatoid Tumor	A small, circumscribed, benign tumor of the genital tract, composed of small glandlike spaces lined by flattened or cuboidal mesothelium-like cells. (From Dorland, 27th ed)	""	0	#FFFFFF
D018255	C04.557.470.035.210	Adenomatosis, Pulmonary	A neoplastic disease in which the alveoli and distal bronchi are filled with mucus and mucus-secreting columnar epithelial cells. It is characterized by abundant, extremely tenacious sputum, chills, fever, cough, dyspnea, and pleuritic pain. (Stedman, 25th ed)	""	0	#FFFFFF
D018256	C04.557.470.035.215	Adenomatous Polyps	Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)	""	0	#FFFFFF
D018261	C04.557.470.035.510.515|C04.557.470.660.510.515	Mesothelioma, Cystic	A peritoneal mesothelioma affecting mainly young females and producing cysts of variable size and number lined by a single layer of benign mesothelial cells. The disease follows a benign course and is compatible with a normal life expectancy, requiring occasionally partial excision or decompression for relief of pain or other symptoms. Malignant potential is exceptional. (From Holland et al., Cancer Medicine, 3d ed, p1345)	""	0	#FFFFFF
D018262	C04.557.470.200.025.045	Adenocarcinoma, Clear Cell	An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)	""	0	#FFFFFF
D018263	C04.557.470.200.025.060	Adenocarcinoma, Follicular	An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)	""	0	#FFFFFF
D018265	C04.557.470.200.025.060.225|C04.557.470.200.025.085.225	Carcinoma, Papillary, Follicular	A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)	""	0	#FFFFFF
D018266	C04.557.470.200.025.105|C04.557.470.550.105	Adenocarcinoma, Sebaceous	A malignant tumor composed of cells showing differentiation toward sebaceous epithelium. The tumor is solitary, firm, somewhat raised, more or less translucent, and covered with normal or slightly verrucose epidermis. It may be yellow or orange. The face and scalp are the commonest sites. The growth can be slow or rapid but metastasis is uncommon. Surgery cures most of the cases. (From Rook et al., Textbook of Dermatology, 4th ed, pp2403-4)	""	0	#FFFFFF
D018267	C04.557.470.200.025.215	Carcinoma, Acinar Cell	A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)	""	0	#FFFFFF
D018268	C04.557.470.200.025.152|C04.588.322.078.265.750|C19.053.098.265.750|C19.053.347.500.750|C19.344.078.265.750	Adrenocortical Carcinoma	A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.	""	0	#FFFFFF
D018269	C04.557.470.200.025.240|C04.588.945.418.948.585.124|C12.050.351.500.056.630.705.331|C12.050.351.937.418.685.331|C12.050.351.937.418.875.200.124|C12.100.250.056.630.705.331|C12.900.418.685.331|C12.900.418.875.200.124|C19.391.630.705.331	Carcinoma, Endometrioid	An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.	""	0	#FFFFFF
D018270	C04.557.470.200.025.232.500|C04.557.470.615.132.500|C04.588.180.390|C17.800.090.500.390	Carcinoma, Ductal, Breast	An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.	""	0	#FFFFFF
D018273	C04.557.470.200.025.290|C04.588.274.761.500|C04.588.322.475.500|C06.301.761.500|C06.689.667.500|C19.344.421.500	Carcinoma, Islet Cell	A primary malignant neoplasm of the pancreatic ISLET CELLS. Usually it involves the non-INSULIN-producing cell types, the PANCREATIC ALPHA CELLS and the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS) in GLUCAGONOMA and SOMATOSTATINOMA, respectively.	""	0	#FFFFFF
D018275	C04.557.470.200.025.305|C04.557.470.615.305|C04.588.180.437|C17.800.090.500.437	Carcinoma, Lobular	A type of BREAST CANCER where the abnormal malignant cells form in the lobules, or milk-producing glands, of the breast.	""	0	#FFFFFF
D018276	C04.557.465.625.650.240.315|C04.557.470.200.025.370.315|C04.557.470.615.315|C04.557.580.625.650.240.315	Carcinoma, Medullary	A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D018277	C04.557.470.200.025.340|C04.557.470.590.340	Carcinoma, Mucoepidermoid	A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)	""	0	#FFFFFF
D018278	C04.557.465.625.650.240|C04.557.470.200.025.370|C04.557.580.625.650.240	Carcinoma, Neuroendocrine	"A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round ""blue cells"", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small (""oat"") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)"	""	0	#FFFFFF
D018279	C04.557.470.200.025.415|C04.557.470.590.415	Carcinoma, Signet Ring Cell	A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.	""	0	#FFFFFF
D018280	C04.557.470.200.025.420|C04.557.470.550.420	Carcinoma, Skin Appendage	A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)	""	0	#FFFFFF
D018281	C04.557.470.200.025.450	Cholangiocarcinoma	A malignant tumor arising from the epithelium of the BILE DUCTS.	""	0	#FFFFFF
D018282	C04.557.470.200.025.480.225|C04.557.470.590.480.225	Cystadenocarcinoma, Mucinous	A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)	""	0	#FFFFFF
D018283	C04.557.470.200.025.480.230|C04.557.470.590.480.230	Cystadenocarcinoma, Papillary	An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.	""	0	#FFFFFF
D018284	C04.557.470.200.025.480.240|C04.557.470.590.480.240	Cystadenocarcinoma, Serous	A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)	""	0	#FFFFFF
D018285	C04.557.470.200.025.450.500	Klatskin Tumor	Cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts (COMMON HEPATIC DUCT). These tumors are generally small, sharply localized, and seldom metastasizing.	""	0	#FFFFFF
D018286	C04.557.470.200.220	Carcinoma, Giant Cell	An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D018287	C04.557.470.200.260	Carcinoma, Large Cell	A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)	""	0	#FFFFFF
D018288	C04.557.470.200.380	Carcinoma, Small Cell	An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)	""	0	#FFFFFF
D018289	C04.557.470.200.450|C04.557.470.700.450	Carcinoma, Verrucous	A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D018290	C04.557.470.200.240.250	Cervical Intraepithelial Neoplasia	A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D018291	C04.557.470.035.320.225|C04.557.470.590.485.225	Cystadenoma, Mucinous	A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.	""	0	#FFFFFF
D018292	C04.557.470.035.320.230|C04.557.470.590.485.230	Cystadenoma, Papillary	A benign neoplasm of the ovary.	""	0	#FFFFFF
D018293	C04.557.470.035.320.240|C04.557.470.590.485.240	Cystadenoma, Serous	A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)	""	0	#FFFFFF
D018294	C04.557.470.550	Neoplasms, Adnexal and Skin Appendage	Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.	""	0	#FFFFFF
D018295	C04.557.470.565	Neoplasms, Basal Cell	Neoplasms composed of cells from the deepest layer of the epidermis. The concept does not refer to neoplasms located in the stratum basale.	""	0	#FFFFFF
D018296	C04.557.470.565.625	Pilomatrixoma	A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401)	""	0	#FFFFFF
D018297	C04.557.470.590	Neoplasms, Cystic, Mucinous, and Serous	Neoplasms containing cyst-like formations or producing mucin or serum.	""	0	#FFFFFF
D018298	C04.557.470.590.580	Mucoepidermoid Tumor	A malignant epithelial tumor of glandular tissue, especially the salivary glands, characterized by acini with mucus-producing cells and by the presence of malignant squamous elements. Most mucoepidermoid tumors are low-grade lesions readily cured by adequate excision. They may appear in any age group. They grow slowly. If high-grade, they behave aggressively, widely infiltrating the salivary gland and producing lymph node and distant metastases. (Dorland, 27th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)	""	0	#FFFFFF
D018299	C04.557.470.615	Neoplasms, Ductal, Lobular, and Medullary	Neoplasms, usually carcinoma, located within the center of an organ or within small lobes, and in the case of the breast, intraductally. The emphasis of the name is on the location of the neoplastic tissue rather than on its histological type. Most cancers of this type are located in the breast.	""	0	#FFFFFF
D018300	C04.557.470.615.670	Papilloma, Intraductal	A small, often impalpable benign papilloma arising in a lactiferous duct and frequently causing bleeding from the nipple. (Stedman, 25th ed)	""	0	#FFFFFF
D018301	C04.557.470.660	Neoplasms, Mesothelial	Neoplasms composed of tissue of the mesothelium, the layer of flat cells, derived from the mesoderm, which lines the body cavity of the embryo. In the adult it forms the simple squamous epithelium which covers all true serous membranes (peritoneum, pericardium, pleura). The concept does not refer to neoplasms located in these organs. (From Dorland, 27th ed)	""	0	#FFFFFF
D018302	C04.557.465.625.600|C04.557.470.670|C04.557.580.625.600	Neoplasms, Neuroepithelial	Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)	""	0	#FFFFFF
D018303	C04.557.465.625.600.380.350|C04.557.470.670.380.350|C04.557.580.625.600.380.350	Ganglioglioma	Rare indolent tumors comprised of neoplastic glial and neuronal cells which occur primarily in children and young adults. Benign lesions tend to be associated with long survival unless the tumor degenerates into a histologically malignant form. They tend to occur in the optic nerve and white matter of the brain and spinal cord.	""	0	#FFFFFF
D018304	C04.557.465.625.600.590.650.550.150|C04.557.470.670.590.650.550.150|C04.557.580.625.600.590.650.550.150|C10.292.650.200	Esthesioneuroblastoma, Olfactory	A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)	""	0	#FFFFFF
D018305	C04.557.465.625.600.590.650.550.300|C04.557.470.670.590.650.550.300|C04.557.580.625.600.590.650.550.300	Ganglioneuroblastoma	A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.	""	0	#FFFFFF
D018306	C04.557.465.625.600.580|C04.557.470.670.580|C04.557.580.625.600.580|C04.588.614.250.195.648|C10.228.140.211.692|C10.551.240.250.550	Neurocytoma	A benign brain tumor composed of neural elements which most often arise from the SEPTUM PELLUCIDUM and the walls of the lateral ventricles. Immunohistochemistry and electron microscopy evaluations may reveal expression of neuron specific enolase and synaptophysin and cells containing microtubuli, neurosecretory granules, and presynaptic vesicles. (From Acta Med Port 1994 Feb;7(2):113-9)	""	0	#FFFFFF
D018307	C04.557.470.700	Neoplasms, Squamous Cell	Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.	""	0	#FFFFFF
D018308	C04.557.470.700.600.610	Papilloma, Inverted	A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)	""	0	#FFFFFF
D018309	C04.557.475	Neoplasms, Gonadal Tissue	Neoplasms composed of tissues of the OVARY or the TESTIS, not neoplasms located in the ovaries or testes. Gonadal tissues include GERM CELLS, cells from the sex cord, and gonadal stromal cells.	""	0	#FFFFFF
D018310	C04.557.475.750.847|C04.588.322.455.648|C04.588.322.762.500|C04.588.945.440.915.500|C12.050.351.500.056.630.705.648|C12.050.351.937.418.685.648|C12.100.250.056.630.705.648|C12.100.500.260.937.500|C12.200.294.260.937.500|C12.200.758.409.937.500|C12.900.418.685.648|C12.900.619.937.500|C19.344.410.648|C19.344.762.500|C19.391.630.705.648|C19.391.829.782.500	Sertoli-Leydig Cell Tumor	A sex cord-gonadal stromal tumor consists of LEYDIG CELLS; SERTOLI CELLS; and FIBROBLASTS in varying proportions and degree of differentiation. Most such tumors produce ANDROGENS in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS.	""	0	#FFFFFF
D018311	C04.557.475.750.751|C04.588.322.455.464|C12.050.351.500.056.630.705.464|C12.050.351.937.418.685.464|C12.100.250.056.630.705.464|C12.900.418.685.464|C19.344.410.464|C19.391.630.705.464	Luteoma	An ovarian neoplasm composed of LUTEAL CELLS derived from luteinized GRANULOSA CELLS and THECA CELLS. Luteomas respond to GONADOTROPINS, and vary in their hormone production (PROGESTERONE; ESTROGENS; or ANDROGENS). During PREGNANCY, a transient type of luteoma may develop due to an exaggerated LUTEINIZATION of the OVARY.	""	0	#FFFFFF
D018312	C04.557.475.750	Sex Cord-Gonadal Stromal Tumors	Neoplasms derived from the primitive sex cord or gonadal stromal cells of the embryonic GONADS. They are classified by their presumed histogenesis and differentiation. From the sex cord, there are SERTOLI CELL TUMOR and GRANULOSA CELL TUMOR; from the gonadal stroma, LEYDIG CELL TUMOR and THECOMA. These tumors may be identified in either the OVARY or the TESTIS.	""	0	#FFFFFF
D018315	C04.557.465.625.600.380.290.390|C04.557.470.670.380.290.390|C04.557.580.625.600.380.290.390	Glioma, Subependymal	Rare, slow-growing, benign intraventricular tumors, often asymptomatic and discovered incidentally. The tumors are classified histologically as ependymomas and demonstrate a proliferation of subependymal fibrillary astrocytes among the ependymal tumor cells. (From Clin Neurol Neurosurg 1997 Feb;99(1):17-22)	""	0	#FFFFFF
D018316	C04.557.465.625.600.380.400|C04.557.470.670.380.400|C04.557.580.625.600.380.400	Gliosarcoma	Rare mixed tumors of the brain and rarely the spinal cord which contain malignant neuroectodermal (glial) and mesenchymal components, including spindle-shaped fibrosarcoma cells. These tumors are highly aggressive and present primarily in adults as rapidly expanding mass lesions. They may arise in tissue that has been previously irradiated. (From Br J Neurosurg 1995 Apr;9(2):171-8)	""	0	#FFFFFF
D018317	C04.557.580.600|C10.551.775.500|C10.668.829.725.500	Nerve Sheath Neoplasms	Neoplasms which arise from nerve sheaths formed by SCHWANN CELLS in the PERIPHERAL NERVOUS SYSTEM or by OLIGODENDROCYTES in the CENTRAL NERVOUS SYSTEM. Malignant peripheral nerve sheath tumors, NEUROFIBROMA, and NEURILEMMOMA are relatively common tumors in this category.	""	0	#FFFFFF
D018318	C04.557.580.600.580.585|C10.551.775.500.750.500|C10.668.829.725.500.600.500	Neurofibroma, Plexiform	A type of neurofibroma manifesting as a diffuse overgrowth of subcutaneous tissue, usually involving the face, scalp, neck, and chest but occasionally occurring in the abdomen or pelvis. The tumors tend to progress, and may extend along nerve roots to eventually involve the spinal roots and spinal cord. This process is almost always a manifestation of NEUROFIBROMATOSIS 1. (From Adams et al., Principles of Neurology, 6th ed, p1016; J Pediatr 1997 Nov;131(5):678-82)	""	0	#FFFFFF
D018319	C04.557.450.565.590.350.590|C04.557.450.795.350.590|C04.557.580.600.580.795|C10.551.775.500.750.750|C10.668.829.725.500.600.600	Neurofibrosarcoma	A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)	""	0	#FFFFFF
D018321	C04.557.450.565.550.625|C04.557.580.600.625	Neurothekeoma	A benign myxoma of cutaneous nerve sheath origin. Theke is from the Greek theke, sheath. (From Stedman, 25th ed)	""	0	#FFFFFF
D018322	C04.557.645.100	Angiofibroma	A benign neoplasm of fibrous tissue in which there are numerous small and large, frequently dilated, vascular channels. (Stedman, 25th ed)	""	0	#FFFFFF
D018323	C04.557.645.375.370.380	Hemangioendothelioma, Epithelioid	"A tumor of medium-to-large veins, composed of plump-to-spindled endothelial cells that bulge into vascular spaces in a tombstone-like fashion. These tumors are thought to have ""borderline"" aggression, where one-third develop local recurrences, but only rarely metastasize. It is unclear whether the epithelioid hemangioendothelioma is truly neoplastic or an exuberant tissue reaction, nor is it clear if this is equivalent to Kimura's disease (see ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA). (Segen, Dictionary of Modern Medicine, 1992)"	""	0	#FFFFFF
D018324	C04.557.645.375.380	Hemangioma, Capillary	A dull red, firm, dome-shaped hemangioma, sharply demarcated from surrounding skin, usually located on the head and neck, which grows rapidly and generally undergoes regression and involution without scarring. It is caused by proliferation of immature capillary vessels in active stroma, and is usually present at birth or occurs within the first two or three months of life. (Dorland, 27th ed)	""	0	#FFFFFF
D018325	C04.557.645.375.380.370	Hemangioblastoma	A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)	""	0	#FFFFFF
D018326	C04.557.665	Nevi and Melanomas	A collective term for the various types of nevi and melanomas.	""	0	#FFFFFF
D018327	C04.557.465.625.650.510.385|C04.557.580.625.650.510.385|C04.557.665.510.385	Hutchinson's Melanotic Freckle	"A cellular subtype of malignant melanoma. It is a pigmented lesion composed of melanocytes occurring on sun-exposed skin, usually the face and neck. The melanocytes are commonly multinucleated with a ""starburst"" appearance. It is considered by many to be the in situ phase of lentigo maligna melanoma."	""	0	#FFFFFF
D018328	C04.557.465.625.650.510.515|C04.557.580.625.650.510.515|C04.557.665.510.515	Melanoma, Amelanotic	An unpigmented malignant melanoma. It is an anaplastic melanoma consisting of cells derived from melanoblasts but not forming melanin. (Dorland, 27th ed; Stedman, 25th ed)	""	0	#FFFFFF
D018329	C04.557.665.560.615.550	Nevus, Blue	Usually a benign tumor, that commonly presents as a solitary blue nodule with spindled MELANOCYTES covered by smooth SKIN. Several variants have been identified, one variant being malignant. The blue color is caused by large, densely packed melanocytes deep in the DERMIS of the nevus. In CHILDREN, they usually occur on the BUTTOCKS and LUMBOSACRAL REGION and are referred to as cellular blue nevi. Malignant blue nevi are more commonly found on the SCALP.	""	0	#FFFFFF
D018330	C04.557.665.560.590	Nevus, Intradermal	A nevus in which nests of melanocytes are found in the dermis, but not at the epidermal-dermal junction. Benign pigmented nevi in adults are most commonly intradermal. (Stedman, 25th ed)	""	0	#FFFFFF
D018331	C04.557.665.560.615.625	Nevus, Spindle Cell	A form of pigmented nevus showing intense melanocytic activity around the dermo-epidermal junction. Large numbers of spindle-shaped melanocytes proliferate downward toward the dermis and usually a large amount of pigment is present. It was first described in 1976 and the bulk of patients reported have been young females with the lesions presenting on the thighs. (From Rook et al., Textbook of Dermatology, 4th ed, 1992, p185)	""	0	#FFFFFF
D018332	C04.557.665.560.615.625.585	Nevus, Epithelioid and Spindle Cell	A benign compound nevus occurring most often in children before puberty, composed of spindle and epithelioid cells located mainly in the dermis, sometimes in association with large atypical cells and multinucleate cells, and having a close histopathological resemblance to malignant melanoma. The tumor presents as a smooth to slightly scaly, round to oval, raised, firm papule or nodule, ranging in color from pink-tan to purplish red, often with surface telangiectasia. (Dorland, 27th ed)	""	0	#FFFFFF
D018333	C04.182.089.530.690.605|C04.557.695.605|C05.500.470.690.605|C07.320.450.670.495	Odontogenic Cyst, Calcifying	A mixed radiolucent-radiopaque lesion of the jaws with features of both a cyst and a solid neoplasm. It is characterized microscopically by an epithelial lining showing a palisaded layer of columnar basal cells, presence of ghost cell keratinization, dentinoid, and calcification. (Stedman, 25th ed)	""	0	#FFFFFF
D018335	C04.557.435.710	Rhabdoid Tumor	A rare but highly lethal childhood tumor found almost exclusively in infants. Histopathologically, it resembles RHABDOMYOSARCOMA but the tumor cells are not of myogenic origin. Although it arises primarily in the kidney, it may be found in other parts of the body. The rhabdoid cytomorphology is believed to be the expression of a very primitive malignant cell. (From Holland et al., Cancer Medicine, 3d ed, p2210)	""	0	#FFFFFF
D018344	C15.378.553.546.605.800|C20.673.627.800	T-Lymphocytopenia, Idiopathic CD4-Positive	Reproducible depletion of CD4+ lymphocytes below 300 per cubic millimeter in the absence of HIV infection or other known causes of immunodeficiency. This is a rare, heterogeneous syndrome and does not appear to be caused by a transmissible agent.	""	0	#FFFFFF
D018347	C01.925.256.430	Hepadnaviridae Infections	Virus diseases caused by the HEPADNAVIRIDAE.	""	0	#FFFFFF
D018352	C01.925.782.600.550.200	Coronavirus Infections	Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).	""	0	#FFFFFF
D018353	C01.925.782.580.830	Rhabdoviridae Infections	Virus diseases caused by RHABDOVIRIDAE. Important infections include RABIES; EPHEMERAL FEVER; and vesicular stomatitis.	""	0	#FFFFFF
D018354	C01.920.500.078|C01.925.782.930.100	Alphavirus Infections	Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.	""	0	#FFFFFF
D018355	C01.925.782.930.700	Rubivirus Infections	Virus diseases caused by the RUBIVIRUS genus, of the family TOGAVIRIDAE.	""	0	#FFFFFF
D018357	C01.925.782.580.600.550.750	Respiratory Syncytial Virus Infections	Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.	""	0	#FFFFFF
D018358	C04.557.465.625.650|C04.557.580.625.650	Neuroendocrine Tumors	Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.	""	0	#FFFFFF
D018365	C04.697.700|C23.550.727.700	Neoplasm, Residual	Remnant of a tumor or cancer after primary, potentially curative therapy.	""	0	#FFFFFF
D018366	C14.907.940.910|C20.543.520.910	Vasculitis, Leukocytoclastic, Cutaneous	Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.	""	0	#FFFFFF
D018370	C16.320.798.719|C20.673.795.719	Leukocyte-Adhesion Deficiency Syndrome	Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection.	""	0	#FFFFFF
D018376	C14.240|C16.131.240	Cardiovascular Abnormalities	Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.	""	0	#FFFFFF
D018382	C19.874.410.500	Thyroid Hormone Resistance Syndrome	An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.	""	0	#FFFFFF
D018404	C23.550.210.430	Isochromosomes	Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.	""	0	#FFFFFF
D018409	C26.558.300	Foot Injuries	General or unspecified injuries involving the foot.	""	0	#FFFFFF
D018410	C01.150.252.620|C01.748.610.540|C08.381.677.540|C08.730.610.540	Pneumonia, Bacterial	Inflammation of the lung parenchyma that is caused by bacterial infections.	""	0	#FFFFFF
D018419	C22.735	Primate Diseases	Diseases of animals within the order PRIMATES. This term includes diseases of Haplorhini and Strepsirhini.	""	0	#FFFFFF
D018420	C22.735.050	Ape Diseases	Diseases of chimpanzees, gorillas, and orangutans.	""	0	#FFFFFF
D018424	C09.218.200|C17.800.428.260.300	Cholesteatoma, Middle Ear	A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR.	""	0	#FFFFFF
D018437	C10.597.622.669.300|C23.888.592.636.637.300	Brown-Sequard Syndrome	A syndrome associated with injury to the lateral half of the spinal cord. The condition is characterized by the following clinical features (which are found below the level of the lesion): contralateral hemisensory anesthesia to pain and temperature, ipsilateral loss of propioception, and ipsilateral motor paralysis. Tactile sensation is generally spared. (From Adams et al., Principles of Neurology, 6th ed, p162).	""	0	#FFFFFF
D018438	C14.907.355.350.454.500.200|C14.907.617.249	Blue Toe Syndrome	A condition that is caused by recurring atheroembolism in the lower extremities. It is characterized by cyanotic discoloration of the toes, usually the first, fourth, and fifth toes. Discoloration may extend to the lateral aspect of the foot. Despite the gangrene-like appearance, blue toes may respond to conservative therapy without amputation.	""	0	#FFFFFF
D018442	C04.557.386.480.150.570|C15.604.515.569.480.150.570|C20.683.515.761.480.150.570	Lymphoma, B-Cell, Marginal Zone	Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.	""	0	#FFFFFF
D018450	C23.550.291.656	Disease Progression	The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.	""	0	#FFFFFF
D018455	C15.378.100.800|C15.378.147.890|C15.378.925.800	Protein S Deficiency	An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)	""	0	#FFFFFF
D018457	C12.050.703.590.767	Placenta, Retained	A placenta that fails to be expelled after BIRTH of the FETUS. A PLACENTA is retained when the UTERUS fails to contract after the delivery of its content, or when the placenta is abnormally attached to the MYOMETRIUM.	""	0	#FFFFFF
D018458	C10.228.140.140.627|C10.597.606.358.800.400|C23.888.592.604.359.800.400	Persistent Vegetative State	Vegetative state refers to the neurocognitive status of individuals with severe brain damage, in whom physiologic functions (sleep-wake cycles, autonomic control, and breathing) persist, but awareness (including all cognitive function and emotion) is abolished.	""	0	#FFFFFF
D018459	C17.800.859.475.605	Lichen Sclerosus et Atrophicus	A chronic inflammatory mucocutaneous disease usually affecting the female genitalia (VULVAR LICHEN SCLEROSUS) and BALANITIS XEROTICA OBLITERANS in males. It is also called white spot disease and Csillag's disease.	""	0	#FFFFFF
D018460	C26.404.186	Fractures, Comminuted	A fracture in which the bone is splintered or crushed into a number of pieces.	""	0	#FFFFFF
D018461	C01.820	Soft Tissue Infections	Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)	""	0	#FFFFFF
D018467	C08.618.846.688	Positive-Pressure Respiration, Intrinsic	Non-therapeutic positive end-expiratory pressure occurring frequently in patients with severe airway obstruction. It can appear with or without the administration of external positive end-expiratory pressure (POSITIVE-PRESSURE RESPIRATION). It presents an important load on the inspiratory muscles which are operating at a mechanical disadvantage due to hyperinflation. Auto-PEEP may cause profound hypotension that should be treated by intravascular volume expansion, increasing the time for expiration, and/or changing from assist mode to intermittent mandatory ventilation mode. (From Harrison's Principles of Internal Medicine, 12th ed, p1127)	""	0	#FFFFFF
D018476	C10.597.350.400|C23.888.592.350.400	Hypokinesia	Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged inactivity due to illness; and other conditions.	""	0	#FFFFFF
D018487	C14.280.945.900	Ventricular Dysfunction, Left	A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.	""	0	#FFFFFF
D018488	C05.116.198.247|C18.452.104.247	Bone Demineralization, Pathologic	Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)	""	0	#FFFFFF
D018489	C23.888.571.800	Space Motion Sickness	Disorder characterized by nausea, vomiting, and dizziness, possibly in response to vestibular disorientation or fluid shifts associated with space flight. (From Webster's New World Dictionary)	""	0	#FFFFFF
D018496	C23.888.852.567	Hyperoxia	An abnormal increase in the amount of oxygen in the tissues and organs.	""	0	#FFFFFF
D018497	C14.280.945.910	Ventricular Dysfunction, Right	A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.	""	0	#FFFFFF
D018500	C12.050.351.968.419.135.500|C12.200.777.419.135.500|C12.950.419.135.500	Diabetes Insipidus, Nephrogenic	A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.	""	0	#FFFFFF
D018512	C01.610.695|C23.550.470.790.500.580	Parasitemia	The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)	""	0	#FFFFFF
D018549	C08.127.446.135.140.200|C08.381.483.652.500.750.249|C08.381.495.146.135.140.200	Cryptogenic Organizing Pneumonia	"An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a ""pneumonia-like"" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts."	""	0	#FFFFFF
D018567	C04.588.180.260|C17.800.090.500.260	Breast Neoplasms, Male	Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.	""	0	#FFFFFF
D018589	C06.405.748.543|C23.888.592.636.263	Gastroparesis	Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.	""	0	#FFFFFF
D018601	C01.150.252.410.040.552.846.719.500	King's Evil	"The historic designation for scrofula (TUBERCULOSIS, LYMPH NODE). The disease is so called from the belief that it could be healed by the touch of a king. This term is used only for historical articles using the name ""king's evil"", and is to be differentiated from scrofula as lymph node tuberculosis in modern clinical medicine. (From Webster, 3d ed)"	""	0	#FFFFFF
D018602	C25.723.756.600	Milk Sickness	An acute, often fatal disease caused by the ingestion of milk, milk products, or the flesh of cattle or sheep which have a disease known as trembles. It is marked by weakness, anorexia, vomiting, constipation, and sometimes muscular tremors. It is caused by poisoning by white snakeroot (Eupatorium rugosum) and the rayless goldenrod (Haplopappus heterophyllus). (From Dorland, 27th ed)	""	0	#FFFFFF
D018614	C23.888.119.344.672	Sweating Sickness	A clinical condition characterized by fever and profuse sweating and associated with high mortality. It occurred in epidemic form five times in the fifteenth and sixteenth centuries in England, first in 1485 and last in 1551, specially during the summer and early autumn, attacking the relatively affluent adult male population. The etiology was unknown.	""	0	#FFFFFF
D018630	C11.768.890	Vitreoretinopathy, Proliferative	Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.	""	0	#FFFFFF
D018633	C14.240.850.937|C14.280.484.640|C16.131.240.850.906	Pulmonary Atresia	A congenital heart defect characterized by the narrowing or complete absence of the opening between the RIGHT VENTRICLE and the PULMONARY ARTERY. Lacking a normal PULMONARY VALVE, unoxygenated blood in the right ventricle can not be effectively pumped into the lung for oxygenation. Clinical features include rapid breathing, CYANOSIS, right ventricle atrophy, and abnormal heart sounds (HEART MURMURS).	""	0	#FFFFFF
D018636	C14.240.400.625|C14.280.400.625|C16.131.240.400.625	Hypoplastic Left Heart Syndrome	A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.	""	0	#FFFFFF
D018640	C07.650|C16.131.850	Stomatognathic System Abnormalities	Congenital structural abnormalities of the mouth and jaws, including the dentition.	""	0	#FFFFFF
D018658	C14.280.470.475.900	Ventricular Septal Rupture	Laceration or tearing of the VENTRICULAR SEPTUM, usually caused by MYOCARDIAL INFARCTION.	""	0	#FFFFFF
D018677	C07.793.850|C26.900	Tooth Injuries	Traumatic or other damage to teeth including fractures (TOOTH FRACTURES) or displacements (TOOTH LUXATION).	""	0	#FFFFFF
D018701	C01.925.782.580	Mononegavirales Infections	Infections with viruses of the order MONONEGAVIRALES. The concept includes FILOVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; and RHABDOVIRIDAE INFECTIONS.	""	0	#FFFFFF
D018702	C01.925.782.580.250	Filoviridae Infections	Infections with viruses of the family FILOVIRIDAE. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.	""	0	#FFFFFF
D018746	C23.550.470.790|C23.550.835.900	Systemic Inflammatory Response Syndrome	A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.	""	0	#FFFFFF
D018754	C14.280.945	Ventricular Dysfunction	A condition in which HEART VENTRICLES exhibit impaired function.	""	0	#FFFFFF
D018761	C04.588.322.400.500|C04.651.600.500|C04.700.630.500|C16.320.700.630.500|C19.344.400.500	Multiple Endocrine Neoplasia Type 1	A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).	""	0	#FFFFFF
D018771	C05.550.091|C23.888.592.612.094	Arthralgia	Pain in the joint.	""	0	#FFFFFF
D018777	C20.543.312.500|C21.223.500	Multiple Chemical Sensitivity	An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)	""	0	#FFFFFF
D018778	C01.925.782.147.420	Hantavirus Infections	Infections with viruses of the genus HANTAVIRUS. This is associated with at least four clinical syndromes: HEMORRHAGIC FEVER WITH RENAL SYNDROME caused by viruses of the Hantaan group; a milder form of HFRS caused by SEOUL VIRUS; nephropathia epidemica caused by PUUMALA VIRUS; and HANTAVIRUS PULMONARY SYNDROME caused by SIN NOMBRE VIRUS.	""	0	#FFFFFF
D018781	C10.228.140.546.399.875	Tension-Type Headache	A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to moderate intensity in the HEAD; SCALP; or NECK. The subtypes are classified by frequency and severity of symptoms. There is no clear cause even though it has been associated with MUSCLE CONTRACTION and stress. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	""	0	#FFFFFF
D018783	C12.100.500.214.500|C12.100.875.486.500|C12.200.294.214.500	Impotence, Vasculogenic	Inability to achieve and maintain an erection (ERECTILE DYSFUNCTION) due to defects in the arterial blood flow to the PENIS, defect in venous occlusive function allowing blood drainage (leakage) from the erectile tissue (corpus cavernosum penis), or both.	""	0	#FFFFFF
D018784	C01.830.025.020	Abdominal Abscess	An abscess located in the abdominal cavity, i.e., the cavity between the diaphragm above and the pelvis below. (From Dorland, 27th ed)	""	0	#FFFFFF
D018785	C14.240.400.920|C14.280.400.920|C14.280.484.845|C16.131.240.400.920	Tricuspid Atresia	Absence of the orifice between the RIGHT ATRIUM and RIGHT VENTRICLE, with the presence of an atrial defect through which all the systemic venous return reaches the left heart. As a result, there is left ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR) because the right ventricle is absent or not functional.	""	0	#FFFFFF
D018792	C01.207.245.340|C01.207.399.750|C01.925.182.525|C10.228.140.430.520.750|C10.228.228.245.340|C10.228.228.399.750|C10.586.250.520.750	Encephalitis, Viral	Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.	""	0	#FFFFFF
D018798	C15.378.071.196.300|C18.452.565.400.500	Anemia, Iron-Deficiency	Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.	""	0	#FFFFFF
D018804	C01.925.782.147.420.380|C08.618.846.450	Hantavirus Pulmonary Syndrome	Acute respiratory illness in humans caused by the SIN NOMBRE VIRUS whose primary rodent reservoir is the deer mouse Peromyscus maniculatus. First identified in the southwestern United States, this syndrome is characterized most commonly by fever, myalgias, headache, cough, and rapid respiratory failure.	""	0	#FFFFFF
D018805	C01.757|C23.550.470.790.500	Sepsis	Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	""	0	#FFFFFF
D018813	C04.588.322.400.505|C04.651.600.505|C04.700.630.505|C16.320.700.630.505|C19.344.400.505	Multiple Endocrine Neoplasia Type 2a	A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.	""	0	#FFFFFF
D018814	C04.588.322.400.510|C04.651.600.510|C04.700.630.510|C16.320.700.630.510|C19.344.400.510	Multiple Endocrine Neoplasia Type 2b	Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.	""	0	#FFFFFF
D018827	C04.557.470.200.280|C04.619.230	Carcinoma, Lewis Lung	A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	""	0	#FFFFFF
D018856	C12.050.351.968.829.495.500|C12.200.777.829.495.500|C12.950.829.495.500	Cystitis, Interstitial	A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.	""	0	#FFFFFF
D018860	C10.228.140.300.750|C14.907.253.774|C17.800.862.775	Sneddon Syndrome	A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of LIVEDO RETICULARIS, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60)	""	0	#FFFFFF
D018876	C20.543.312|C21.223	Environmental Illness	"A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this ""disease"", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)"	""	0	#FFFFFF
D018877	C20.543.312.750|C21.223.750	Sick Building Syndrome	A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (ALVEOLITIS, EXTRINSIC ALLERGIC); allergic rhinitis (RHINITIS, ALLERGIC, PERENNIAL); ASTHMA; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)	""	0	#FFFFFF
D018879	C14.280.067.325.500|C14.280.123.375.500|C23.550.073.325.800	Ventricular Premature Complexes	A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.	""	0	#FFFFFF
D018880	C14.280.067.325.250|C14.280.123.375.250|C23.550.073.325.050	Atrial Premature Complexes	A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites. The ectopic signals may or may not conduct to the HEART VENTRICLES. Atrial premature complexes are characterized by premature P waves on ECG which are different in configuration from the P waves generated by the normal pacemaker complex in the SINOATRIAL NODE.	""	0	#FFFFFF
D018882	C26.522	Heat Stress Disorders	A group of conditions that develop due to overexposure or overexertion in excessive environmental heat.	""	0	#FFFFFF
D018883	C26.522.500	Heat Stroke	A condition caused by the failure of body to dissipate heat in an excessively hot environment or during PHYSICAL EXERTION in a hot environment. Contrast to HEAT EXHAUSTION, the body temperature in heat stroke patient is dangerously high with red, hot skin accompanied by DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.	""	0	#FFFFFF
D018886	C10.597.606.150.500.800.100.111|C23.888.592.604.150.500.800.100.111	Aphasia, Conduction	A type of fluent aphasia characterized by an impaired ability to repeat one and two word phrases, despite retained comprehension. This condition is associated with dominant hemisphere lesions involving the arcuate fasciculus (a white matter projection between Broca's and Wernicke's areas) and adjacent structures. Like patients with Wernicke aphasia (APHASIA, WERNICKE), patients with conduction aphasia are fluent but commit paraphasic errors during attempts at written and oral forms of communication. (From Adams et al., Principles of Neurology, 6th ed, p482; Brain & Bannister, Clinical Neurology, 7th ed, p142; Kandel et al., Principles of Neural Science, 3d ed, p848)	""	0	#FFFFFF
D018887	C10.228.140.490.493.500	Landau-Kleffner Syndrome	A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495).	""	0	#FFFFFF
D018888	C10.228.140.380.132|C10.597.606.150.500.800.100.155|C23.888.592.604.150.500.800.100.155	Aphasia, Primary Progressive	A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)	""	0	#FFFFFF
D018901	C16.320.565.663|C18.452.648.663	Peroxisomal Disorders	A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.	""	0	#FFFFFF
D018902	C05.116.099.708.195.200|C16.320.565.663.265|C18.452.648.663.265	Chondrodysplasia Punctata, Rhizomelic	An autosomal recessive form of CHONDRODYSPLASIA PUNCTATA characterized by defective plasmalogen biosynthesis and impaired peroxisomes. Patients have shortened proximal limbs and severely disturbed endochondral bone formation. The metabolic defects associated with the impaired peroxisomes are present only in the rhizomelic form of chondrodysplasia punctata. (From Scriver et al, Metabolic Basis of Inherited Disease, 6th ed, p1497)	""	0	#FFFFFF
D018908	C05.651.515|C10.597.613.593|C23.550.695|C23.888.592.608.593	Muscle Weakness	A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)	""	0	#FFFFFF
D018917	C10.292.700.600|C11.640.643|C14.907.601	Optic Neuropathy, Ischemic	Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)	""	0	#FFFFFF
D018921	C15.378.553.560	Leukostasis	Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.	""	0	#FFFFFF
D018923	C24.653	Persian Gulf Syndrome	Unexplained symptoms reported by veterans of the Persian Gulf War with Iraq in 1991. The symptoms reported include fatigue, skin rash, muscle and joint pain, headaches, loss of memory, shortness of breath, gastrointestinal and respiratory symptoms, and extreme sensitivity to commonly occurring chemicals. (Nature 1994 May 5;369(6475):8)	""	0	#FFFFFF
D018934	C01.150.252.377|C12.100.500.229|C12.200.294.229	Fournier Gangrene	An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease.	""	0	#FFFFFF
D018979	C05.651.594.600|C10.668.491.562.500	Myositis, Inclusion Body	Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy. Sporadic and hereditary forms have been described. The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles. Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue. (Adams et al., Principles of Neurology, 6th ed, pp1409-10)	""	0	#FFFFFF
D018980	C10.597.606.360.970|C14.280.484.048.750.535.960|C16.131.260.970|C16.320.180.970	Williams Syndrome	A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.	""	0	#FFFFFF
D018981	C16.320.565.202.125|C18.452.648.202.125	Congenital Disorders of Glycosylation	A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.	""	0	#FFFFFF
D019042	C04.588.839.500|C05.651.494	Muscle Neoplasms	Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.	""	0	#FFFFFF
D019043	C04.588.839.750|C14.907.936	Vascular Neoplasms	Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.	""	0	#FFFFFF
D019046	C04.588.448.200|C15.378.190.250|C15.378.400.200	Bone Marrow Neoplasms	Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.	""	0	#FFFFFF
D019048	C04.557.470.200.240.500	Prostatic Intraepithelial Neoplasia	A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.	""	0	#FFFFFF
D019052	C12.050.703.844.253	Depression, Postpartum	Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)	""	0	#FFFFFF
D019053	C01.221.250.875.398|C01.221.812.640.400.480|C01.778.640.400.480|C01.925.782.815.616.400.398|C01.925.813.400.480|C06.405.469.400|C12.100.937.640.400.480|C20.673.480.480	HIV Enteropathy	A syndrome characterized by chronic, well-established DIARRHEA (greater than one month in duration) without an identified infectious cause after thorough evaluation, in an HIV-positive individual. It is thought to be due to direct or indirect effects of HIV on the enteric mucosa. HIV enteropathy is a diagnosis of exclusion and can be made only after other forms of diarrheal illness have been ruled out. (Harrison's Principles of Internal Medicine, 13th ed, pp1607-8; Haubrich et al., Bockus Gastroenterology, 5th ed, p1155)	""	0	#FFFFFF
D019066	C23.550.291.812	Facies	The appearance of the face that is often characteristic of a disease or pathological condition, as the elfin facies of WILLIAMS SYNDROME or the mongoloid facies of DOWN SYNDROME. (Random House Unabridged Dictionary, 2d ed)	""	0	#FFFFFF
D019080	C17.800.621.250|C23.888.885.250	Cafe-au-Lait Spots	Light brown pigmented macules associated with NEUROFIBROMATOSIS and Albright's syndrome (see FIBROUS DYSPLASIA, POLYOSTOTIC).	""	0	#FFFFFF
D019082	C16.131.077.860|C16.320.565.398.850|C16.320.565.925.875|C18.452.584.500.937|C18.452.584.563.850|C18.452.648.398.850|C18.452.648.925.875	Smith-Lemli-Opitz Syndrome	An autosomal recessive disorder of CHOLESTEROL metabolism. It is caused by a deficiency of 7-dehydrocholesterol reductase, the enzyme that converts 7-dehydrocholesterol to cholesterol, leading to an abnormally low plasma cholesterol. This syndrome is characterized by multiple CONGENITAL ABNORMALITIES, growth deficiency, and INTELLECTUAL DISABILITY.	""	0	#FFFFFF
D019106	C23.550.414.941|C23.550.767.850	Postoperative Hemorrhage	Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.	""	0	#FFFFFF
D019115	C05.321.550	Fasciitis, Necrotizing	A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.	""	0	#FFFFFF
D019121	C01.150.252.400.170	Burkholderia Infections	Infections with bacteria of the genus BURKHOLDERIA.	""	0	#FFFFFF
D019142	C01.925.782.417.415|C01.925.782.580.250.400	Hemorrhagic Fever, Ebola	A highly fatal, acute hemorrhagic fever caused by EBOLAVIRUS.	""	0	#FFFFFF
D019150	C10.228.140.744	Neuroaxonal Dystrophies	A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)	""	0	#FFFFFF
D019189	C18.452.565	Iron Metabolism Disorders	Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization. (From Mosby's Medical, Nursing, & Allied Health Dictionary, 4th ed)	""	0	#FFFFFF
D019190	C18.452.565.500	Iron Overload	An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)	""	0	#FFFFFF
D019214	C07.465.714.258.428	Gingival Overgrowth	Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)	""	0	#FFFFFF
D019217	C07.793.818.249	Tooth Attrition	The wearing away of a tooth as a result of tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces. It is chiefly associated with aging. It is differentiated from TOOTH ABRASION (the pathologic wearing away of the tooth substance by friction, as brushing, bruxism, clenching, and other mechanical causes) and from TOOTH EROSION (the loss of substance caused by chemical action without bacterial action). (Jablonski, Dictionary of Dentistry, 1992, p86)	""	0	#FFFFFF
D019226	C07.465.672	Oral Ulcer	A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)	""	0	#FFFFFF
D019247	C01.221.250.875.520|C01.221.812.640.400.520|C01.778.640.400.520|C01.925.782.815.616.400.520|C01.925.813.400.520|C12.100.937.640.400.520|C18.452.915.520|C18.654.940.520|C20.673.480.520	HIV Wasting Syndrome	Involuntary weight loss of greater than 10 percent associated with intermittent or constant fever and chronic diarrhea or fatigue for more than 30 days in the absence of a defined cause other than HIV infection. A constant feature is major muscle wasting with scattered myofiber degeneration. A variety of etiologies, which vary among patients, contributes to this syndrome. (From Harrison's Principles of Internal Medicine, 13th ed, p1611).	""	0	#FFFFFF
D019280	C16.131.077.208|C16.131.260.090|C16.320.180.090	Branchio-Oto-Renal Syndrome	An autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to Mondini type cochlear defect and stapes fixation. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)	""	0	#FFFFFF
D019282	C18.452.915|C18.654.940	Wasting Syndrome	A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism.	""	0	#FFFFFF
D019283	C06.689.750.650	Pancreatitis, Acute Necrotizing	A severe form of acute INFLAMMATION of the PANCREAS characterized by one or more areas of NECROSIS in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. Massive pancreatic necrosis may lead to DIABETES MELLITUS, and malabsorption.	""	0	#FFFFFF
D019292	C04.588.149.721.828|C05.116.231.754.829	Skull Base Neoplasms	Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).	""	0	#FFFFFF
D019294	C16.320.565.398.925|C18.452.584.563.925|C18.452.584.750.975|C18.452.648.398.925	Xanthomatosis, Cerebrotendinous	An autosomal recessive lipid storage disorder due to mutation of the gene CYP27A1 encoding a CHOLESTANETRIOL 26-MONOOXYGENASE. It is characterized by large deposits of CHOLESTEROL and CHOLESTANOL in various tissues resulting in xanthomatous swelling of tendons, early CATARACT, and progressive neurological symptoms.	""	0	#FFFFFF
D019305	C10.228.140.490.360.280|C10.228.140.490.493.250	Epilepsy, Rolandic	An autosomal dominant inherited partial epilepsy syndrome with onset between age 3 and 13 years. Seizures are characterized by PARESTHESIA and tonic or clonic activity of the lower face associated with drooling and DYSARTHRIA. In most cases, affected children are neurologically and developmentally normal. (From Epilepsia 1998 39;Suppl 4:S32-S41)	""	0	#FFFFFF
D019310	C15.604.613	Pseudolymphoma	A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (From Dorland, 28th ed & Stedman, 26th ed)	""	0	#FFFFFF
D019315	C11.675.700|C23.550.414.960	Retrobulbar Hemorrhage	Hemorrhage within the orbital cavity, posterior to the eyeball.	""	0	#FFFFFF
D019318	C01.925.782.600.100.700|C22.905.700	Porcine Reproductive and Respiratory Syndrome	A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)	""	0	#FFFFFF
D019320	C14.907.355.590.400	Embolism, Paradoxical	Blockage of an artery due to passage of a clot (THROMBUS) from a systemic vein to a systemic artery without its passing through the lung which acts as a filter to remove blood clots from entering the arterial circulation. Paradoxical embolism occurs when there is a defect that allows a clot to cross directly from the right to the left side of the heart as in the cases of ATRIAL SEPTAL DEFECTS or open FORAMEN OVALE. Once in the arterial circulation, a clot can travel to the brain, block an artery, and cause a STROKE.	""	0	#FFFFFF
D019337	C04.588.448|C15.378.400	Hematologic Neoplasms	Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.	""	0	#FFFFFF
D019339	C16.131.831.675|C17.800.804.675	Port-Wine Stain	A vascular malformation of developmental origin characterized pathologically by ectasia of superficial dermal capillaries, and clinically by persistent macular erythema. In the past, port wine stains have frequently been termed capillary hemangiomas, which they are not; unfortunately this confusing practice persists: HEMANGIOMA, CAPILLARY is neoplastic, a port-wine stain is non-neoplastic. Port-wine stains vary in color from fairly pale pink to deep red or purple and in size from a few millimeters to many centimeters in diameter. The face is the most frequently affected site and they are most often unilateral. (From Rook et al., Textbook of Dermatology, 5th ed, p483)	""	0	#FFFFFF
D019349	C01.925.256.466.850	Roseolovirus Infections	Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.	""	0	#FFFFFF
D019350	C01.925.782.105	Astroviridae Infections	Infections with ASTROVIRIDAE, causing gastroenteritis in human infants, calves, lambs, and piglets.	""	0	#FFFFFF
D019351	C01.925.782.580.600.680	Rubulavirus Infections	Infections with viruses of the genus RUBULAVIRUS, family PARAMYXOVIRIDAE.	""	0	#FFFFFF
D019446	C01.757.100.275|C01.861.375|C23.550.470.790.500.100.275	Endotoxemia	A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.	""	0	#FFFFFF
D019449	C06.405.205.462.624.500|C06.405.469.326.875.500|C06.405.469.420.520.500	Pouchitis	Acute INFLAMMATION in the INTESTINAL MUCOSA of the continent ileal reservoir (or pouch) in patients who have undergone ILEOSTOMY and restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).	""	0	#FFFFFF
D019457	C23.550.210.170	Chromosome Breakage	A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.	""	0	#FFFFFF
D019462	C10.177.575.600.800|C10.597.606.358.800.600.500|C23.888.592.604.359.800.600.500	Syncope, Vasovagal	Loss of consciousness due to a reduction in blood pressure that is associated with an increase in vagal tone and peripheral vasodilation.	""	0	#FFFFFF
D019465	C05.660.207|C16.131.621.207	Craniofacial Abnormalities	Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.	""	0	#FFFFFF
D019512	C06.689.750.660|C25.775.100.087.730	Pancreatitis, Alcoholic	Acute or chronic INFLAMMATION of the PANCREAS due to excessive ALCOHOL DRINKING. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.	""	0	#FFFFFF
D019522	C12.050.351.500.894.700|C12.100.250.894.700	Vaginal Discharge	A common gynecologic disorder characterized by an abnormal, nonbloody discharge from the genital tract.	""	0	#FFFFFF
D019534	C05.550.840|C26.803.500	Shoulder Impingement Syndrome	Compression of the ROTATOR CUFF tendons and subacromial bursa between the HUMERAL HEAD and  the ACROMION of the SCAPULA. This condition is associated with subacromial BURSITIS, as well as rotator cuff (largely supraspinatus) and bicipital tendon INFLAMMATION.	""	0	#FFFFFF
D019547	C23.888.592.612.553	Neck Pain	Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.	""	0	#FFFFFF
D019553	C07.793.237.910	Tooth, Nonvital	A tooth from which the dental pulp has been removed or is necrotic. (Boucher, Clinical Dental Terminology, 4th ed)	""	0	#FFFFFF
D019557	C17.800.174.550|C17.800.271.250	Dermatitis, Perioral	A papular eruption of unknown etiology that progresses to residual papular erythema and scaling usually confined to the area of the mouth, and almost exclusively occurring in young women. It may also be localized or extend to involve the eyelids and adjacent glabella area of the forehead (periocular dermatitis). (Dorland, 28th ed)	""	0	#FFFFFF
D019559	C14.907.218	Capillary Leak Syndrome	A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.	""	0	#FFFFFF
D019567	C26.117	Back Injuries	General or unspecified injuries to the posterior part of the trunk. It includes injuries to the muscles of the back.	""	0	#FFFFFF
D019568	C08.381.570	Lung, Hyperlucent	A lung with reduced markings on its chest radiograph and increased areas of transradiancy (hyperlucency). A hyperlucent lung is usually associated with pulmonary emphysema or PNEUMOTHORAX.	""	0	#FFFFFF
D019569	C07.465.364|C10.597.613.750.400|C23.888.592.608.750.400	Hemifacial Spasm	Recurrent clonic contraction of facial muscles, restricted to one side. It may occur as a manifestation of compressive lesions involving the seventh cranial nerve (FACIAL NERVE DISEASES), during recovery from BELL PALSY, or in association with other disorders. (From Adams et al., Principles of Neurology, 6th ed, p1378)	""	0	#FFFFFF
D019571	C14.240.400.145|C14.280.238.028|C14.280.400.145|C16.131.240.400.145	Arrhythmogenic Right Ventricular Dysplasia	A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.	""	0	#FFFFFF
D019572	C04.588.364.818|C11.319.475|C11.768.717	Retinal Neoplasms	Tumors or cancer of the RETINA.	""	0	#FFFFFF
D019574	C04.588.614.300.600|C04.588.614.596.240.240|C10.292.225.800|C10.292.700.500|C10.551.360.500|C10.551.775.250.500|C11.640.544	Optic Nerve Neoplasms	Benign and malignant neoplasms that arise from the optic nerve or its sheath. OPTIC NERVE GLIOMA is the most common histologic type. Optic nerve neoplasms tend to cause unilateral visual loss and an afferent pupillary defect and may spread via neural pathways to the brain.	""	0	#FFFFFF
D019575	C10.597.751.941.162.250|C11.966.075.250|C23.888.592.763.941.162.250	Blindness, Cortical	Total loss of vision in all or part of the visual field due to bilateral OCCIPITAL LOBE (i.e., VISUAL CORTEX) damage or dysfunction. Anton syndrome is characterized by the psychic denial of true, organic cortical blindness. (Adams et al., Principles of Neurology, 6th ed, p460)	""	0	#FFFFFF
D019578	C10.177.575.550|C10.228.140.079.612|C10.228.662.550|C10.574.928.625	Multiple System Atrophy	A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)	""	0	#FFFFFF
D019584	C23.888.475	Hot Flashes	A sudden, temporary sensation of heat predominantly experienced by some women during MENOPAUSE. (Random House Unabridged Dictionary, 2d ed)	""	0	#FFFFFF
D019585	C10.228.140.638	Intracranial Hypotension	Reduction of CEREBROSPINAL FLUID pressure characterized clinically by ORTHOSTATIC HEADACHE and occasionally by an ABDUCENS NERVE PALSY; HEARING LOSS; NAUSEA; neck stiffness, and other symptoms. This condition may be spontaneous or secondary to CEREBROSPINAL FLUID LEAK; SPINAL PUNCTURE; NEUROSURGICAL PROCEDURES; DEHYDRATION; UREMIA; trauma (see also CRANIOCEREBRAL TRAUMA); and other processes. Chronic hypotension may be associated with subdural hematomas (see HEMATOMA, SUBDURAL) or hygromas. (From Semin Neurol 1996 Mar;16(1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)	""	0	#FFFFFF
D019586	C10.228.140.631	Intracranial Hypertension	Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.	""	0	#FFFFFF
D019588	C23.888.069	Aging, Premature	Changes in the organism associated with senescence, occurring at an accelerated rate.	""	0	#FFFFFF
D019591	C23.888.681	Pseudophakia	Presence of an intraocular lens after cataract extraction.	""	0	#FFFFFF
D019595	C01.920.500.270.200|C01.925.081.270.200|C01.925.782.350.250.214.200|C01.925.782.417.214.200	Severe Dengue	A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.	""	0	#FFFFFF
D019636	C10.574	Neurodegenerative Diseases	Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	""	0	#FFFFFF
D019687	C12.050.351.500.852.726|C12.050.703.420.814|C12.100.250.852.726	Uterine Inversion	A complication of OBSTETRIC LABOR in which the corpus of the UTERUS is forced completely or partially through the UTERINE CERVIX. This can occur during the late stages of labor and is associated with IMMEDIATE POSTPARTUM HEMORRHAGE.	""	0	#FFFFFF
D019693	C06.552.380.350.300|C20.111.567	Hepatitis, Autoimmune	A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.	""	0	#FFFFFF
D019694	C01.221.250.500.100|C01.925.256.430.400.100|C01.925.440.435.100|C06.552.380.350.100|C06.552.380.705.437.100|C23.550.291.500.477.500	Hepatitis B, Chronic	INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	""	0	#FFFFFF
D019698	C01.221.250.750.120|C01.925.440.440.120|C01.925.782.350.350.120|C06.552.380.350.120|C06.552.380.705.440.120|C23.550.291.500.477.750	Hepatitis C, Chronic	INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.	""	0	#FFFFFF
D019701	C01.925.440.450.100|C01.925.782.450.100|C06.552.380.350.220|C06.552.380.705.450.100|C23.550.291.500.477.875	Hepatitis D, Chronic	INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS in conjunction with HEPATITIS B VIRUS and lasting six months or more.	""	0	#FFFFFF
D019767	C05.660.207.540|C07.650.500|C16.131.621.207.540|C16.131.850.500	Maxillofacial Abnormalities	Congenital structural deformities, malformations, or other abnormalities of the maxilla and face or facial bones.	""	0	#FFFFFF
D019773	C11.768.328	Epiretinal Membrane	A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) RETINAL PIGMENT EPITHELIUM. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the FOVEA CENTRALIS. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with RETINAL HOLES, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)	""	0	#FFFFFF
D019838	C26.700	Neck Injuries	General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.	""	0	#FFFFFF
D019846	C10.114.750.100.500|C10.228.140.252.500|C10.292.562.350|C10.314.750.450.500|C10.668.829.350.500|C10.668.829.800.750.300.500|C11.590.312|C20.111.258.750.400.500	Miller Fisher Syndrome	A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)	""	0	#FFFFFF
D019851	C15.378.925	Thrombophilia	A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.	""	0	#FFFFFF
D019867	C08.381.483.156|C12.050.351.968.419.570.363.304|C12.200.777.419.570.363.304|C12.950.419.570.363.304|C20.111.190	Anti-Glomerular Basement Membrane Disease	An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.	""	0	#FFFFFF
D019871	C15.378.190.223.500.750|C16.131.831.150|C16.320.322.108|C16.320.850.235|C17.800.804.150|C17.800.827.235	Dyskeratosis Congenita	A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.	""	0	#FFFFFF
D019873	C20.683.780.640.700	Schnitzler Syndrome	An extremely rare condition manifested as monoclonal IMMUNOGLOBULIN M dysproteinemia without features of lymphoproliferative disease, but with chronic urticaria, fever of unknown origin, disabling bone pain, hyperostosis, and increased erythrocyte sedimentation rate.	""	0	#FFFFFF
D019896	C06.552.074|C08.381.112|C16.320.060|C23.550.325.500.500	alpha 1-Antitrypsin Deficiency	Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.	""	0	#FFFFFF
D019954	C10.597.606|C23.888.592.604	Neurobehavioral Manifestations	Signs and symptoms of higher cortical dysfunction caused by organic conditions. These include certain behavioral alterations and impairments of skills involved in the acquisition, processing, and utilization of knowledge or information.	""	0	#FFFFFF
D019966	C25.775	Substance-Related Disorders	Disorders related to substance use or abuse.	""	0	#FFFFFF
D019969	C25.775.225	Amphetamine-Related Disorders	Disorders related or resulting from use of amphetamines.	""	0	#FFFFFF
D019970	C25.775.300	Cocaine-Related Disorders	Disorders related or resulting from use of cocaine.	""	0	#FFFFFF
D019973	C25.775.100	Alcohol-Related Disorders	Disorders related to or resulting from abuse or misuse of alcohol.	""	0	#FFFFFF
D020016	C15.378.100.100.037|C15.378.100.141.036|C15.378.925.050|C16.320.099.037	Activated Protein C Resistance	A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.	""	0	#FFFFFF
D020019	C01.207.205.250.550|C01.610.105.250.550|C01.610.335.190.902.185.550|C10.228.228.205.250.550	Neurocysticercosis	Infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus TAENIA (primarily T. solium in humans). Lesions formed by the organism are referred to as cysticerci. The infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. SEIZURES represent the most common clinical manifestation although focal neurologic deficits may occur. (From Joynt, Clinical Neurology, 1998, Ch27, pp46-50)	""	0	#FFFFFF
D020022	C23.550.291.687.500	Genetic Predisposition to Disease	A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.	""	0	#FFFFFF
D020031	C01.925.256.466.313|C01.925.928.313	Epstein-Barr Virus Infections	Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).	""	0	#FFFFFF
D020042	C15.604.315.300	Histiocytic Necrotizing Lymphadenitis	Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue.	""	0	#FFFFFF
D020047	C06.405.469.860.810|C23.300.707.984	Rectocele	Herniation of the RECTUM into the VAGINA.	""	0	#FFFFFF
D020065	C06.552.455|C08.381.385	Hepatopulmonary Syndrome	A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).	""	0	#FFFFFF
D020069	C05.550.091.700|C23.888.592.612.094.700	Shoulder Pain	Unilateral or bilateral pain of the shoulder. It is often caused by physical activities such as work or sports participation, but may also be pathologic in origin.	""	0	#FFFFFF
D020078	C10.597.609|C23.550.470.448	Neurogenic Inflammation	Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.	""	0	#FFFFFF
D020083	C05.116.099.708.025	Acquired Hyperostosis Syndrome	Syndrome consisting of SYNOVITIS; ACNE CONGLOBATA; PALMOPLANTAR PUSTULOSIS; HYPEROSTOSIS; and OSTEITIS. The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome.	""	0	#FFFFFF
D020096	C01.150.703.980	Zygomycosis	Infection in humans and animals caused by fungi in the class Zygomycetes. It includes MUCORMYCOSIS and entomophthoramycosis. The latter is a tropical infection of subcutaneous tissue or paranasal sinuses caused by fungi in the order Entomophthorales. Phycomycosis, closely related to zygomycosis, describes infection with members of Phycomycetes, an obsolete classification.	""	0	#FFFFFF
D020132	C23.550.291.687.500.500	Anticipation, Genetic	The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)	""	0	#FFFFFF
D020138	C16.320.565.100.480|C18.452.603.378|C18.452.648.100.480|C18.654.521.500.133.699.418	Hyperhomocysteinemia	Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.	""	0	#FFFFFF
D020139	C05.660.417|C16.131.621.417|C23.300.707.374.500	Gastroschisis	A congenital defect with major fissure in the ABDOMINAL WALL lateral to, but not at, the UMBILICUS. This results in the extrusion of VISCERA. Unlike OMPHALOCELE, herniated structures in gastroschisis are not covered by a sac or PERITONEUM.	""	0	#FFFFFF
D020140	C10.228.140.163.100.435|C16.320.565.189.435|C16.320.565.595.554|C18.452.132.100.435|C18.452.648.189.435|C18.452.648.595.554	Lysosomal Storage Diseases, Nervous System	A group of enzymatic disorders affecting the nervous system and to a variable degree the skeletal system, lymphoreticular system, and other organs. The conditions are marked by an abnormal accumulation of catabolic material within lysosomes.	""	0	#FFFFFF
D020141	C14.907.454|C15.378.463.515	Hemostatic Disorders	Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS.	""	0	#FFFFFF
D020143	C10.228.140.163.100.435.825.300.300|C16.320.565.189.435.825.300.300|C16.320.565.398.641.803.350.300|C16.320.565.595.554.825.300.300|C18.452.132.100.435.825.300.300|C18.452.584.563.641.803.350.300|C18.452.648.189.435.825.300.300|C18.452.648.398.641.803.350.300|C18.452.648.595.554.825.300.300	Gangliosidoses, GM2	A group of recessively inherited diseases characterized by the intralysosomal accumulation of G(M2) GANGLIOSIDE in the neuronal cells. Subtypes include mutations of enzymes in the BETA-N-ACETYLHEXOSAMINIDASES system or G(M2) ACTIVATOR PROTEIN leading to disruption of normal degradation of GANGLIOSIDES, a subclass of ACIDIC GLYCOSPHINGOLIPIDS.	""	0	#FFFFFF
D020144	C10.228.140.079.127|C10.228.140.300.100|C14.907.253.061	Basal Ganglia Cerebrovascular Disease	A pathological condition caused by impaired blood flow in the basal regions of cerebral hemispheres (BASAL GANGLIA), such as INFARCTION; HEMORRHAGE; or ISCHEMIA in vessels of this brain region including the lateral lenticulostriate arteries. Primary clinical manifestations include involuntary movements (DYSKINESIAS) and muscle weakness (HEMIPARESIS).	""	0	#FFFFFF
D020145	C10.228.140.079.127.500|C10.228.140.300.100.200|C10.228.140.300.535.200.150|C14.907.253.061.200|C14.907.253.573.200.150|C23.550.414.913.100.200	Basal Ganglia Hemorrhage	Bleeding within the subcortical regions of cerebral hemispheres (BASAL GANGLIA). It is often associated with HYPERTENSION or ARTERIOVENOUS MALFORMATIONS. Clinical manifestations may include HEADACHE; DYSKINESIAS; and HEMIPARESIS.	""	0	#FFFFFF
D020146	C10.228.140.079.127.500.500|C10.228.140.300.100.200.500|C10.228.140.300.535.200.150.500|C14.907.253.061.200.500|C14.907.253.573.200.150.500|C23.550.414.913.100.200.500	Putaminal Hemorrhage	Intracranial bleeding into the PUTAMEN, a BASAL GANGLIA nucleus. This is associated with HYPERTENSION and lipohyalinosis of small blood vessels in the putamen. Clinical manifestations vary with the size of hemorrhage, but include HEMIPARESIS; HEADACHE; and alterations of consciousness.	""	0	#FFFFFF
D020147	C15.378.100.141	Coagulation Protein Disorders	Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.	""	0	#FFFFFF
D020149	C10.720.475.500|C25.723.522.813	Manganese Poisoning	Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)	""	0	#FFFFFF
D020150	C10.228.140.079.294|C10.228.662.262.249.500|C12.050.703.141	Chorea Gravidarum	A rare movement disorder developed during PREGNANCY, characterized by involuntary jerky motion (CHOREA) and inability to maintain stable position of body parts (ATHETOSIS). RHEUMATIC FEVER and collagen vascular disorders are frequently associated with this disease. Chorea may vary from mild to severe and occurs in approximately 1 per 2,000 to 3,000 pregnancies. (From Md Med J 1997 Sep;46(8):436-9)	""	0	#FFFFFF
D020151	C15.378.100.100.690|C15.378.147.880|C15.378.925.795|C16.320.099.690	Protein C Deficiency	An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)	""	0	#FFFFFF
D020152	C15.378.100.100.075|C15.378.147.150|C15.378.925.075|C16.320.099.075	Antithrombin III Deficiency	An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis.	""	0	#FFFFFF
D020157	C16.320.565.151|C18.452.648.151	Amino Acid Transport Disorders, Inborn	Disorders characterized by defective transport of amino acids across cell membranes. These include deficits in transport across brush-border epithelial cell membranes of the small intestine (MICROVILLI) and KIDNEY TUBULES; transport across the basolateral membrane; and transport across the membranes of intracellular organelles. (From Nippon Rinsho 1992 Jul;50(7):1587-92)	""	0	#FFFFFF
D020158	C10.228.140.163.100.375|C16.320.565.100.477|C16.320.565.189.375|C18.452.132.100.375|C18.452.648.100.477|C18.452.648.189.375	Hyperglycinemia, Nonketotic	An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system.	""	0	#FFFFFF
D020159	C10.228.140.163.100.937.374|C16.320.565.100.940.374|C16.320.565.189.937.374|C18.452.132.100.937.374|C18.452.648.100.940.374|C18.452.648.189.937.374	Citrullinemia	A group of diseases related to a deficiency of the enzyme ARGININOSUCCINATE SYNTHASE which causes an elevation of serum levels of CITRULLINE. In neonates, clinical manifestations include lethargy, hypotonia, and SEIZURES. Milder forms also occur. Childhood and adult forms may present with recurrent episodes of intermittent weakness, lethargy, ATAXIA, behavioral changes, and DYSARTHRIA. (From Menkes, Textbook of Child Neurology, 5th ed, p49)	""	0	#FFFFFF
D020162	C10.228.140.163.100.937.500|C16.320.565.100.940.500|C16.320.565.189.937.500|C18.452.132.100.937.437|C18.452.648.100.940.437|C18.452.648.189.937.437	Hyperargininemia	A rare autosomal recessive disorder of the urea cycle. It is caused by a deficiency of the hepatic enzyme ARGINASE. Arginine is elevated in the blood and cerebrospinal fluid, and periodic HYPERAMMONEMIA may occur. Disease onset is usually in infancy or early childhood. Clinical manifestations include seizures, microcephaly, progressive mental impairment, hypotonia, ataxia, spastic diplegia, and quadriparesis. (From Hum Genet 1993 Mar;91(1):1-5; Menkes, Textbook of Child Neurology, 5th ed, p51)	""	0	#FFFFFF
D020163	C10.228.140.163.100.937.750|C16.320.322.828|C16.320.565.100.940.750|C16.320.565.189.937.750|C18.452.132.100.937.500|C18.452.648.100.940.500|C18.452.648.189.937.500	Ornithine Carbamoyltransferase Deficiency Disease	An inherited urea cycle disorder associated with deficiency of the enzyme ORNITHINE CARBAMOYLTRANSFERASE, transmitted as an X-linked trait and featuring elevations of amino acids and ammonia in the serum. Clinical features, which are more prominent in males, include seizures, behavioral alterations, episodic vomiting, lethargy, and coma. (Menkes, Textbook of Child Neurology, 5th ed, pp49-50)	""	0	#FFFFFF
D020165	C10.228.140.163.100.937.249|C16.320.565.100.940.249|C16.320.565.189.937.249|C18.452.132.100.937.249|C18.452.648.100.940.249|C18.452.648.189.937.249|C18.452.660.097	Carbamoyl-Phosphate Synthase I Deficiency Disease	A urea cycle disorder manifesting in infancy as lethargy, emesis, seizures, alterations of muscle tone, abnormal eye movements, and an elevation of serum ammonia. The disorder is caused by a reduction in the activity of hepatic mitochondrial CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA). (Menkes, Textbook of Child Neurology, 5th ed, pp50-1)	""	0	#FFFFFF
D020167	C10.228.140.163.100.380|C16.320.565.100.544|C16.320.565.189.380|C18.452.132.100.380|C18.452.648.100.544|C18.452.648.189.380	Hyperlysinemias	A group of inherited metabolic disorders which have in common elevations of serum LYSINE levels. Enzyme deficiencies of alpha-aminoadipic semialdehyde dehydrogenase and the SACCHAROPINE DEHYDROGENASES have been associated with hyperlysinemia. Clinical manifestations include mental retardation, recurrent emesis, hypotonia, lethargy, diarrhea, and developmental delay. (From Menkes, Textbook of Child Neurology, 5th ed, p56)	""	0	#FFFFFF
D020176	C10.228.140.163.100.875|C16.320.565.100.880|C16.320.565.189.875|C18.452.132.100.875|C18.452.648.100.880|C18.452.648.189.875	Tyrosinemias	A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)	""	0	#FFFFFF
D020177	C10.886.425.800.200.400	Idiopathic Hypersomnia	A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)	""	0	#FFFFFF
D020178	C10.281.800|C10.886.425.200|C24.900	Sleep Disorders, Circadian Rhythm	Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.	""	0	#FFFFFF
D020179	C10.281.440|C10.886.425.200.500|C23.888.914.500	Jet Lag Syndrome	A chronobiologic disorder resulting from rapid travel across a number of time zones, characterized by insomnia or hypersomnolence, fatigue, behavioral symptoms, headaches, and gastrointestinal disturbances. (From Cooper, Sleep, 1994, pp593-8)	""	0	#FFFFFF
D020181	C08.618.085.852.850|C10.886.425.800.750.850	Sleep Apnea, Obstructive	A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)	""	0	#FFFFFF
D020182	C08.618.085.852.800|C10.886.425.800.750.800	Sleep Apnea, Central	A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration.	""	0	#FFFFFF
D020183	C10.886.659.627	Nocturnal Paroxysmal Dystonia	A parasomnia characterized by paroxysmal episodes of choreoathetotic, ballistic, dystonic movements, and semipurposeful activity. The episodes occur during non-rapid eye movement sleep and typically recur several times per night. (Neurology 1992 Jul;42(7 Suppl 6):61-67; Adams et al., Principles of Neurology, 6th ed, p391)	""	0	#FFFFFF
D020184	C10.886.659.635.600	Night Terrors	A disorder characterized by incomplete arousals from sleep associated with behavior suggesting extreme fright. This condition primarily affects children and young adults and the individual generally has no recall of the event. Episodes tend to occur during stage III or IV. SOMNAMBULISM is frequently associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p391)	""	0	#FFFFFF
D020186	C07.793.099.500|C10.886.659.637	Sleep Bruxism	A sleep disorder characterized by grinding and clenching of the teeth and forceful lateral or protrusive jaw movements. Sleep bruxism may be associated with TOOTH INJURIES; TEMPOROMANDIBULAR JOINT DISORDERS; sleep disturbances; and other conditions.	""	0	#FFFFFF
D020187	C10.886.659.633.700	REM Sleep Behavior Disorder	A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)	""	0	#FFFFFF
D020188	C10.886.659.633.800	Sleep Paralysis	A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)	""	0	#FFFFFF
D020189	C10.886.425.800.600|C10.886.659.618	Nocturnal Myoclonus Syndrome	Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)	""	0	#FFFFFF
D020190	C10.228.140.490.375.130.670|C10.228.140.490.493.063.670	Myoclonic Epilepsy, Juvenile	A disorder characterized by the onset of myoclonus in adolescence, a marked increase in the incidence of absence seizures (see EPILEPSY, ABSENCE), and generalized major motor seizures (see EPILEPSY, TONIC-CLONIC). The myoclonic episodes tend to occur shortly after awakening. Seizures tend to be aggravated by sleep deprivation and alcohol consumption. Hereditary and sporadic forms have been identified. (From Adams et al., Principles of Neurology, 6th ed, p323)	""	0	#FFFFFF
D020191	C10.228.140.490.375.130.650|C10.228.140.490.493.063.650	Myoclonic Epilepsies, Progressive	A heterogeneous group of primarily familial EPILEPSY disorders characterized by myoclonic seizures, tonic-clonic seizures, ataxia, progressive intellectual deterioration, and neuronal degeneration. These include LAFORA DISEASE; MERRF SYNDROME; NEURONAL CEROID-LIPOFUSCINOSIS; sialidosis (see MUCOLIPIDOSES), and UNVERRICHT-LUNDBORG SYNDROME.	""	0	#FFFFFF
D020192	C10.228.140.490.375.130.650.500|C10.228.140.490.493.063.650.500|C10.574.500.529|C16.320.400.480	Lafora Disease	A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).	""	0	#FFFFFF
D020194	C10.228.140.490.375.130.650.900|C10.228.140.490.493.063.650.900|C10.574.500.875|C16.320.400.940	Unverricht-Lundborg Syndrome	An autosomal recessive condition characterized by recurrent myoclonic and generalized seizures, ATAXIA, slowly progressive intellectual deterioration, DYSARTHRIA, and intention tremor. Myoclonic seizures are severe and continuous, and tend to be triggered by movement, stress, and sensory stimuli. The age of onset is between 8 and 13 years, and the condition is relatively frequent in the Baltic region, especially Finland. (From Menkes, Textbook of Child Neurology, 5th ed, pp109-110)	""	0	#FFFFFF
D020195	C10.228.140.490.450	Epilepsy, Reflex	A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)	""	0	#FFFFFF
D020196	C10.900|C26.915	Trauma, Nervous System	Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.	""	0	#FFFFFF
D020197	C10.900.300.675|C26.915.300.475|C26.986.500	Head Injuries, Penetrating	Head injuries which feature compromise of the skull and dura mater. These may result from gunshot wounds (WOUNDS, GUNSHOT), stab wounds (WOUNDS, STAB), and other forms of trauma.	""	0	#FFFFFF
D020198	C10.228.140.300.535.450|C10.900.300.837|C14.907.253.573.400|C26.915.300.490	Intracranial Hemorrhage, Traumatic	Bleeding within the SKULL induced by penetrating and nonpenetrating traumatic injuries, including hemorrhages into the tissues of CEREBRUM; BRAIN STEM; and CEREBELLUM; as well as into the epidural, subdural and subarachnoid spaces of the MENINGES.	""	0	#FFFFFF
D020199	C10.228.140.300.535.450.400.050|C10.900.300.837.600.050|C14.907.253.573.400.450.050|C23.550.414.838.700.100|C23.550.414.913.700.100|C26.915.300.490.450.050	Hematoma, Subdural, Acute	Accumulation of blood in the SUBDURAL SPACE with acute onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.	""	0	#FFFFFF
D020200	C10.228.140.300.535.450.400.120|C10.900.300.837.600.120|C14.907.253.573.400.450.120|C23.550.291.500.431|C23.550.414.838.700.200|C23.550.414.913.700.200|C26.915.300.490.450.120	Hematoma, Subdural, Chronic	Accumulation of blood in the SUBDURAL SPACE with delayed onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.	""	0	#FFFFFF
D020201	C10.228.140.199.275|C10.228.140.300.535.450.200|C10.900.300.087.187|C10.900.300.837.150|C14.907.253.573.400.150|C26.915.300.200.175|C26.915.300.490.150	Brain Hemorrhage, Traumatic	Bleeding within the brain as a result of penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA. Traumatically induced hemorrhages may occur in any area of the brain, including the CEREBRUM; BRAIN STEM (see BRAIN STEM HEMORRHAGE, TRAUMATIC); and CEREBELLUM.	""	0	#FFFFFF
D020202	C10.228.140.199.275.300|C10.228.140.300.535.200.200|C10.228.140.300.535.450.200.750|C10.900.300.087.187.300|C10.900.300.837.150.650|C14.907.253.573.200.200|C14.907.253.573.400.150.300|C26.915.300.200.175.300|C26.915.300.490.150.300	Cerebral Hemorrhage, Traumatic	Bleeding into one or both CEREBRAL HEMISPHERES due to TRAUMA. Hemorrhage may involve any part of the CEREBRAL CORTEX and the BASAL GANGLIA. Depending on the severity of bleeding, clinical features may include SEIZURES; APHASIA; VISION DISORDERS; MOVEMENT DISORDERS; PARALYSIS; and COMA.	""	0	#FFFFFF
D020203	C10.228.140.199.275.200|C10.228.140.300.535.450.200.500|C10.900.300.087.187.200|C10.900.300.837.150.300|C14.907.253.573.400.150.200|C26.915.300.200.175.200|C26.915.300.490.150.200	Brain Stem Hemorrhage, Traumatic	Bleeding into structures of BRAIN STEM, including the MIDBRAIN; PONS; or MEDULLA OBLONGATA, as the result of CRANIOCEREBRAL TRAUMA. DIFFUSE AXONAL INJURY is commonly associated. Clinical manifestations may include OCULAR MOTILITY DISORDERS; ATAXIA; PARALYSIS; PERSISTENT VEGETATIVE STATE; and COMA.	""	0	#FFFFFF
D020204	C10.900.300.918.300|C26.404.750.890|C26.915.300.745.350	Skull Fracture, Depressed	A skull fracture characterized by inward depression of a fragment or section of cranial bone, often compressing the underlying dura mater and brain. Depressed cranial fractures which feature open skin wounds that communicate with skull fragments are referred to as compound depressed skull fractures.	""	0	#FFFFFF
D020205	C10.900.300.918.150|C26.404.750.821|C26.915.300.745.300	Skull Fracture, Basilar	Fractures which extend through the base of the SKULL, usually involving the PETROUS BONE. Battle's sign (characterized by skin discoloration due to extravasation of blood into the subcutaneous tissue behind the ear and over the mastoid process), CRANIAL NEUROPATHIES, TRAUMATIC; CAROTID-CAVERNOUS SINUS FISTULA; and CEREBROSPINAL FLUID OTORRHEA are relatively frequent sequelae of this condition. (Adams et al., Principles of Neurology, 6th ed, p876)	""	0	#FFFFFF
D020206	C10.228.140.300.535.450.650|C10.228.140.300.535.800.700|C10.900.300.837.800|C14.907.253.535.600|C14.907.253.573.400.700|C14.907.253.573.800.700|C26.915.300.490.700	Subarachnoid Hemorrhage, Traumatic	Bleeding into the SUBARACHNOID SPACE due to CRANIOCEREBRAL TRAUMA. Minor hemorrhages may be asymptomatic; moderate to severe hemorrhages may be associated with INTRACRANIAL HYPERTENSION and VASOSPASM, INTRACRANIAL.	""	0	#FFFFFF
D020207	C10.597.606.358.800.200.200|C10.900.300.175|C26.915.300.350	Coma, Post-Head Injury	Prolonged unconsciousness from which the individual cannot be aroused, associated with traumatic injuries to the BRAIN. This may be defined as unconsciousness persisting for 6 hours or longer. Coma results from injury to both cerebral hemispheres or the RETICULAR FORMATION of the BRAIN STEM. Contributing mechanisms include DIFFUSE AXONAL INJURY and BRAIN EDEMA. (From J Neurotrauma 1997 Oct;14(10):699-713)	""	0	#FFFFFF
D020208	C10.228.140.140.127|C10.228.140.199.500|C10.900.300.087.250|C23.550.291.500.063.500|C26.915.300.200.200	Brain Injury, Chronic	Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from DIFFUSE AXONAL INJURY; INTRACRANIAL HEMORRHAGES; BRAIN EDEMA; and other conditions. Clinical features may include DEMENTIA; focal neurologic deficits; PERSISTENT VEGETATIVE STATE; AKINETIC MUTISM; or COMA.	""	0	#FFFFFF
D020209	C10.292.200|C10.900.300.218|C26.915.300.400	Cranial Nerve Injuries	Dysfunction of one or more cranial nerves causally related to a traumatic injury. Penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA; NECK INJURIES; and trauma to the facial region are conditions associated with cranial nerve injuries.	""	0	#FFFFFF
D020210	C10.228.854.763.500|C10.900.850.625|C26.819.339	Central Cord Syndrome	A syndrome associated with traumatic injury to the cervical or upper thoracic regions of the spinal cord characterized by weakness in the arms with relative sparing of the legs and variable sensory loss. This condition is associated with ischemia, hemorrhage, or necrosis involving the central portions of the spinal cord. Corticospinal fibers destined for the legs are spared due to their more external location in the spinal cord. This clinical pattern may emerge during recovery from spinal shock. Deficits may be transient or permanent.	""	0	#FFFFFF
D020211	C10.177.090|C10.900.850.250	Autonomic Dysreflexia	A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)	""	0	#FFFFFF
D020212	C10.228.140.300.200.345|C10.228.140.300.350.500|C10.900.250.300|C14.907.253.123.345|C14.907.253.535.500|C26.915.200.200	Carotid Artery Injuries	Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)	""	0	#FFFFFF
D020214	C10.228.140.300.350|C10.900.250|C14.907.253.535|C26.915.200	Cerebrovascular Trauma	Penetrating and nonpenetrating traumatic injuries to an extracranial or intracranial blood vessel that supplies the brain. This includes the CAROTID ARTERIES; VERTEBRAL ARTERIES; MENINGEAL ARTERIES; CEREBRAL ARTERIES; veins, and venous sinuses.	""	0	#FFFFFF
D020215	C10.228.140.300.200.345.300|C10.228.140.300.350.500.300|C10.900.250.300.300|C14.907.055.050.150|C14.907.253.123.345.300|C14.907.253.535.500.300|C26.915.200.200.500	Carotid Artery, Internal, Dissection	The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.	""	0	#FFFFFF
D020216	C10.228.140.300.200.480|C10.228.140.300.350.500.350|C10.900.250.300.400|C14.240.850.750.147.500|C14.240.850.984.750.500|C14.907.150.125.500|C14.907.253.123.357|C14.907.253.535.500.350|C14.907.933.555.500|C16.131.240.850.750.125.500|C23.300.575.950.250.500|C26.915.200.200.550	Carotid-Cavernous Sinus Fistula	An acquired or spontaneous abnormality in which there is communication between CAVERNOUS SINUS, a venous structure, and the CAROTID ARTERIES. It is often associated with HEAD TRAUMA, specifically basilar skull fractures (SKULL FRACTURE, BASILAR). Clinical signs often include VISION DISORDERS and INTRACRANIAL HYPERTENSION.	""	0	#FFFFFF
D020217	C10.228.140.300.350.875|C10.900.250.650|C14.907.055.050.575|C14.907.253.535.800|C26.915.200.600	Vertebral Artery Dissection	Splitting of the vessel wall in the VERTEBRAL ARTERY. Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the vertebral artery, aneurysm formation, or THROMBOEMBOLISM. Vertebral artery dissection is often associated with TRAUMA and injuries to the head-neck region but can occur spontaneously.	""	0	#FFFFFF
D020220	C07.465.299.500|C10.292.200.500|C10.292.319.500|C10.900.300.218.300|C26.915.300.400.300	Facial Nerve Injuries	"Traumatic injuries to the facial nerve. This may result in FACIAL PARALYSIS, decreased lacrimation and salivation, and loss of taste sensation in the anterior tongue. The nerve may regenerate and reform its original pattern of innervation, or regenerate aberrantly, resulting in inappropriate lacrimation in response to gustatory stimuli (e.g., ""crocodile tears"") and other syndromes."	""	0	#FFFFFF
D020221	C10.292.200.750|C10.292.700.475|C10.900.300.218.550|C11.640.530|C26.915.300.400.650	Optic Nerve Injuries	Injuries to the optic nerve induced by a trauma to the face or head. These may occur with closed or penetrating injuries. Relatively minor compression of the superior aspect of orbit may also result in trauma to the optic nerve. Clinical manifestations may include visual loss, PAPILLEDEMA, and an afferent pupillary defect.	""	0	#FFFFFF
D020222	C10.292.150.100|C10.292.200.200|C10.900.300.218.150|C26.915.300.400.100	Abducens Nerve Injury	Traumatic injury to the abducens, or sixth, cranial nerve. Injury to this nerve results in lateral rectus muscle weakness or paralysis. The nerve may be damaged by closed or penetrating CRANIOCEREBRAL TRAUMA or by facial trauma involving the orbit.	""	0	#FFFFFF
D020225	C10.228.140.300.525.425.500.750|C14.907.253.566.350.500.750|C14.907.355.590.213.350.500.750	Sagittal Sinus Thrombosis	Formation or presence of a blood clot (THROMBUS) in the SUPERIOR SAGITTAL SINUS or the inferior sagittal sinus. Sagittal sinus thrombosis can result from infections, hematological disorders, CRANIOCEREBRAL TRAUMA; and NEUROSURGICAL PROCEDURES. Clinical features are primarily related to the increased intracranial pressure causing HEADACHE; NAUSEA; and VOMITING. Severe cases can evolve to SEIZURES or COMA.	""	0	#FFFFFF
D020226	C10.228.140.300.525.425.500.375|C14.907.253.566.350.500.375|C14.907.355.590.213.350.500.375	Cavernous Sinus Thrombosis	Formation or presence of a blood clot (THROMBUS) in the CAVERNOUS SINUS of the brain. Infections of the paranasal sinuses and adjacent structures, CRANIOCEREBRAL TRAUMA, and THROMBOPHILIA are associated conditions. Clinical manifestations include dysfunction of cranial nerves III, IV, V, and VI, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)	""	0	#FFFFFF
D020227	C10.228.140.300.525.425.500.562|C14.907.253.566.350.500.562|C14.907.355.590.213.350.500.562	Lateral Sinus Thrombosis	Formation or presence of a blood clot (THROMBUS) in the LATERAL SINUSES. This condition is often associated with ear infections (OTITIS MEDIA or MASTOIDITIS) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; NEUROSURGICAL PROCEDURES; THROMBOPHILIA; and other conditions. Clinical features include HEADACHE; VERTIGO; and increased intracranial pressure.	""	0	#FFFFFF
D020230	C25.100.875	Serotonin Syndrome	An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.	""	0	#FFFFFF
D020232	C10.228.140.380.326	Kluver-Bucy Syndrome	A neurobehavioral syndrome associated with bilateral medial temporal lobe dysfunction. Clinical manifestations include oral exploratory behavior; tactile exploratory behavior; hypersexuality; BULIMIA; MEMORY DISORDERS; placidity; and an inability to recognize objects or faces. This disorder may result from a variety of conditions, including CRANIOCEREBRAL TRAUMA; infections; ALZHEIMER DISEASE; PICK DISEASE OF THE BRAIN; and CEREBROVASCULAR DISORDERS.	""	0	#FFFFFF
D020233	C10.597.404|C23.888.592.413	Gait Disorders, Neurologic	Gait abnormalities that are a manifestation of nervous system dysfunction. These conditions may be caused by a wide variety of disorders which affect motor control, sensory feedback, and muscle strength including: CENTRAL NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or MUSCULAR DISEASES.	""	0	#FFFFFF
D020234	C10.597.350.090.750|C10.597.404.450|C23.888.592.350.090.600|C23.888.592.413.450	Gait Ataxia	Impairment of the ability to coordinate the movements required for normal ambulation (WALKING) which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.	""	0	#FFFFFF
D020235	C10.597.404.400|C10.597.606.881.350.600|C23.888.592.413.400|C23.888.592.604.882.350.600	Gait Apraxia	Impaired ambulation not attributed to sensory impairment or motor weakness. FRONTAL LOBE disorders; BASAL GANGLIA DISEASES (e.g., PARKINSONIAN DISORDERS); DEMENTIA, MULTI-INFARCT; ALZHEIMER DISEASE; and other conditions may be associated with gait apraxia.	""	0	#FFFFFF
D020236	C10.228.140.060|C10.597.606.525.100.800|C23.888.592.604.529.100.800	Amnesia, Transient Global	A syndrome characterized by a transient loss of the ability to form new memories. It primarily occurs in middle aged or elderly individuals, and episodes may last from minutes to hours. During the period of amnesia, immediate and recent memory abilities are impaired, but the level of consciousness and ability to perform other intellectual tasks are preserved. The condition is related to bilateral dysfunction of the medial portions of each TEMPORAL LOBE. Complete recovery normally occurs, and recurrences are unusual. (From Adams et al., Principles of Neurology, 6th ed, pp429-30)	""	0	#FFFFFF
D020237	C10.597.606.150.500.300.200.100|C23.888.592.604.150.500.300.200.100	Alexia, Pure	"Loss of the power to comprehend written materials despite preservation of the ability to write (i.e., alexia without agraphia). This condition is generally attributed to lesions that ""disconnect"" the visual cortex of the non-dominant hemisphere from language centers in the dominant hemisphere. This may occur when a dominant visual cortex injury is combined with underlying white matter lesions that involve crossing fibers from the occipital lobe of the opposite hemisphere. (From Adams et al., Principles of Neurology, 6th ed, p483)"	""	0	#FFFFFF
D020238	C10.597.606.762.100.650|C23.888.592.604.764.100.650	Prosopagnosia	The inability to recognize a familiar face or to learn to recognize new faces. This visual agnosia is most often associated with lesions involving the junctional regions between the temporal and occipital lobes. The majority of cases are associated with bilateral lesions, however unilateral damage to the right occipito-temporal cortex has also been associated with this condition. (From Cortex 1995 Jun;31(2):317-29).	""	0	#FFFFFF
D020240	C10.597.606.881.350.200|C23.888.592.604.882.350.200	Apraxia, Ideomotor	A form of apraxia characterized by an acquired inability to carry out a complex motor activity despite the ability to mentally formulate the action. This condition has been attributed to a disruption of connections between the dominant parietal cortex and supplementary and premotor cortical regions in both hemispheres. (From Adams et al., Principles of Neurology, 6th ed, p57)	""	0	#FFFFFF
D020241	C01.207.245.340.450.800|C01.207.291.323.662|C01.207.399.750.450.800|C01.920.500.078.370.662|C01.920.500.343.655.677|C01.925.081.343.655.677|C01.925.182.525.450.300|C01.925.782.930.100.370.662|C10.228.140.430.520.750.450.800|C10.228.228.245.340.450.800|C10.228.228.291.323.662|C10.228.228.399.750.450.800|C10.586.250.520.750.450.800|C10.586.500.406.250	Encephalomyelitis, Western Equine	A form of arboviral encephalitis (which primarily affects horses) endemic to western and central regions of NORTH AMERICA. The causative organism (ENCEPHALOMYELITIS VIRUS, WESTERN EQUINE) may be transferred to humans via the bite of mosquitoes (CULEX tarsalis and others). Clinical manifestations include headache and influenza-like symptoms followed by alterations in mentation, SEIZURES, and COMA. DEATH occurs in a minority of cases. Survivors may recover fully or be left with residual neurologic dysfunction, including PARKINSONISM, POSTENCEPHALITIC. (From Joynt, Clinical Neurology, 1996, Ch26, pp8-9)	""	0	#FFFFFF
D020242	C01.207.245.340.450.200|C01.207.291.323.162|C01.207.399.750.450.200|C01.920.500.078.370.162|C01.920.500.343.655.177|C01.925.081.343.655.177|C01.925.782.930.100.370.162|C10.228.140.430.520.750.450.200|C10.228.228.245.340.450.200|C10.228.228.291.323.162|C10.228.228.399.750.450.200|C10.586.250.520.750.450.200|C10.586.500.406.200	Encephalomyelitis, Eastern Equine	A form of arboviral encephalitis (primarily affecting equines) endemic to eastern regions of North America. The causative organism (ENCEPHALOMYELITIS VIRUS, EASTERN EQUINE) may be transmitted to humans via the bite of AEDES mosquitoes. Clinical manifestations include the acute onset of fever, HEADACHE, altered mentation, and SEIZURES followed by coma. The condition is fatal in up to 50% of cases. Recovery may be marked by residual neurologic deficits and EPILEPSY. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)	""	0	#FFFFFF
D020243	C10.228.140.300.150.477.200.400|C10.228.140.300.510.200.325|C10.228.140.300.775.200.200.400|C14.907.253.092.477.200.400|C14.907.253.560.200.325|C14.907.253.855.200.200.400|C23.550.513.355.250.200.400|C23.550.717.489.250.200.400	Infarction, Anterior Cerebral Artery	NECROSIS occurring in the ANTERIOR CEREBRAL ARTERY system, including branches such as Heubner's artery. These arteries supply blood to the medial and superior parts of the CEREBRAL HEMISPHERE, Infarction in the anterior cerebral artery usually results in sensory and motor impairment in the lower body.	""	0	#FFFFFF
D020244	C10.228.140.300.150.477.200.450|C10.228.140.300.510.200.387|C10.228.140.300.775.200.200.450|C14.907.253.092.477.200.450|C14.907.253.560.200.387|C14.907.253.855.200.200.450|C23.550.513.355.250.200.450|C23.550.717.489.250.200.450	Infarction, Middle Cerebral Artery	NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.	""	0	#FFFFFF
D020246	C14.907.355.830.925	Venous Thrombosis	The formation or presence of a blood clot (THROMBUS) within a vein.	""	0	#FFFFFF
D020250	C23.550.767.859|C23.888.821.712.700|C23.888.821.937.059	Postoperative Nausea and Vomiting	Emesis and queasiness occurring after anesthesia.	""	0	#FFFFFF
D020252	C06.405.748.280|C14.907.075.280	Gastric Antral Vascular Ectasia	A distinct vascular lesion in the PYLORIC ANTRUM that is characterized by tortuous dilated blood vessels (ectasia) radiating outward from the PYLORUS. The vessel pattern resembles the stripes on the surface of a watermelon. This lesion causes both acute and chronic GASTROINTESTINAL HEMORRHAGE.	""	0	#FFFFFF
D020254	C07.793.710	Tooth Ankylosis	Solid fixation of a tooth resulting from fusion of the cementum and alveolar bone, with obliteration of the periodontal ligament. It is uncommon in the deciduous dentition and very rare in permanent teeth. (Jablonski's Dictionary of Dentistry, 1992)	""	0	#FFFFFF
D020255	C11.980	Vitreous Detachment	Detachment of the corpus vitreum (VITREOUS BODY) from its normal attachments, especially the retina, due to shrinkage from degenerative or inflammatory conditions, trauma, myopia, or senility.	""	0	#FFFFFF
D020256	C11.941.160.244|C23.550.589.500.145	Choroidal Neovascularization	A pathological process consisting of the formation of new blood vessels in the CHOROID.	""	0	#FFFFFF
D020257	C23.300.985	Ventricular Remodeling	The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.	""	0	#FFFFFF
D020258	C10.720|C25.723.705	Neurotoxicity Syndromes	Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.	""	0	#FFFFFF
D020260	C10.720.475	Heavy Metal Poisoning, Nervous System	Conditions associated with damage or dysfunction of the nervous system caused by exposure to heavy metals, which may cause a variety of central, peripheral, or autonomic nervous system injuries.	""	0	#FFFFFF
D020261	C10.720.475.150|C25.723.098	Arsenic Poisoning	Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)	""	0	#FFFFFF
D020262	C10.720.475.600|C25.723.522.875.500	Mercury Poisoning, Nervous System	Neurologic disorders associated with exposure to inorganic and organic forms of MERCURY. Acute intoxication may be associated with gastrointestinal disturbances, mental status changes, and PARAPARESIS. Chronic exposure to inorganic mercury usually occurs in industrial workers, and manifests as mental confusion, prominent behavioral changes (including psychosis), DYSKINESIAS, and NEURITIS. Alkyl mercury poisoning may occur through ingestion of contaminated seafood or grain, and its characteristic features include POLYNEUROPATHY; ATAXIA; vision loss; NYSTAGMUS, PATHOLOGIC; and DEAFNESS. (From Joynt, Clinical Neurology, 1997, Ch20, pp10-15)	""	0	#FFFFFF
D020263	C10.720.475.400|C25.723.522.750.500	Lead Poisoning, Nervous System	Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, NERVOUS SYSTEM, CHILDHOOD) and adults (LEAD POISONING, NERVOUS SYSTEM, ADULT). In children, lead poisoning typically produces an encephalopathy. In adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.	""	0	#FFFFFF
D020264	C10.720.475.400.700|C25.723.522.750.500.700	Lead Poisoning, Nervous System, Childhood	Neurologic disorders occurring in children following lead exposure. The most frequent manifestation of childhood lead toxicity is an encephalopathy associated with chronic ingestion of lead that usually presents between the ages of 1 and 3 years. Clinical manifestations include behavioral changes followed by lethargy; CONVULSIONS; HALLUCINATIONS; DELIRIUM; ATAXIA; and vomiting. Elevated intracranial pressure (HYPERTENSION, INTRACRANIAL) and CEREBRAL EDEMA may occur. (From Adams et al., Principles of Neurology, 6th ed, p1210-2)	""	0	#FFFFFF
D020265	C10.720.475.400.350|C25.723.522.750.500.400	Lead Poisoning, Nervous System, Adult	Neurologic conditions in adults associated with acute or chronic exposure to lead or any of its salts. The most common lead related neurologic syndrome in adults consists of a polyneuropathy involving motor fibers. This tends to affect distal nerves and may present as wrist drop due to RADIAL NEUROPATHY. Additional features of chronic lead exposure include ANEMIA; CONSTIPATION; colicky abdominal pain; a bluish lead line of the gums; interstitial nephritis (NEPHRITIS, INTERSTITIAL); and saturnine gout. An encephalopathy may rarely occur. (From Adams et al., Principles of Neurology, 6th ed, p1212)	""	0	#FFFFFF
D020267	C10.228.140.079.862.800.300|C10.228.662.600.700.250|C10.720.606|C25.723.705.400	MPTP Poisoning	A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)	""	0	#FFFFFF
D020268	C10.720.112|C25.723.705.150|C25.775.100.087.193	Alcohol-Induced Disorders, Nervous System	Acute and chronic neurologic disorders associated with the various neurologic effects of ETHANOL. Primary sites of injury include the brain and peripheral nerves.	""	0	#FFFFFF
D020269	C10.668.829.800.050|C10.720.112.400|C25.723.705.150.400|C25.775.100.087.193.400	Alcoholic Neuropathy	A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)	""	0	#FFFFFF
D020270	C10.597.742.143|C10.720.112.300|C23.888.592.742.143|C25.723.705.150.300|C25.775.100.087.193.300|C25.775.835.500	Alcohol Withdrawal Seizures	A condition where seizures occur in association with ethanol abuse (ALCOHOLISM) without other identifiable causes. Seizures usually occur within the first 6-48 hours after the cessation of alcohol intake, but may occur during periods of alcohol intoxication. Single generalized tonic-clonic motor seizures are the most common subtype, however, STATUS EPILEPTICUS may occur. (Adams et al., Principles of Neurology, 6th ed, p1174)	""	0	#FFFFFF
D020271	C10.574.500|C16.320.400	Heredodegenerative Disorders, Nervous System	Inherited disorders characterized by progressive atrophy and dysfunction of anatomically or physiologically related neurologic systems.	""	0	#FFFFFF
D020274	C10.114|C20.111.258	Autoimmune Diseases of the Nervous System	Disorders caused by cellular or humoral immune responses primarily directed towards nervous system autoantigens. The immune response may be directed towards specific tissue components (e.g., myelin) and may be limited to the central nervous system (e.g., MULTIPLE SCLEROSIS) or the peripheral nervous system (e.g., GUILLAIN-BARRE SYNDROME).	""	0	#FFFFFF
D020275	C10.114.750.100|C10.314.750.450|C10.668.829.350|C10.668.829.800.750.300|C20.111.258.750.400	Guillain-Barre Syndrome	An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)	""	0	#FFFFFF
D020277	C10.114.750.175|C10.314.750.700|C10.668.829.800.750.600|C20.111.258.750.800|C23.550.291.500.813	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)	""	0	#FFFFFF
D020278	C10.114.375|C10.228.140.695.562|C10.314.350|C20.111.258.250	Demyelinating Autoimmune Diseases, CNS	Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens.	""	0	#FFFFFF
D020279	C10.228.140.163.100.362|C10.228.140.695.625|C10.314.400|C10.574.500.490|C16.320.400.367|C16.320.565.189.362|C18.452.132.100.362|C18.452.648.189.362	Hereditary Central Nervous System Demyelinating Diseases	Inherited conditions characterized by a loss of MYELIN in the central nervous system.	""	0	#FFFFFF
D020288	C04.588.614.250.195.205.200.500|C10.228.140.211.280.300.500|C10.551.240.250.200.200.500	Papilloma, Choroid Plexus	A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)	""	0	#FFFFFF
D020293	C10.114.875|C10.228.140.300.850|C14.907.253.946|C14.907.940.907|C20.111.258.962	Vasculitis, Central Nervous System	Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)	""	0	#FFFFFF
D020294	C10.668.758.800|C16.320.590	Myasthenic Syndromes, Congenital	A heterogeneous group of disorders characterized by a congenital defect in neuromuscular transmission at the NEUROMUSCULAR JUNCTION. This includes presynaptic, synaptic, and postsynaptic disorders (that are not of autoimmune origin). The majority of these diseases are caused by mutations of various subunits of the nicotinic acetylcholine receptor (RECEPTORS, NICOTINIC) on the postsynaptic surface of the junction. (From Arch Neurol 1999 Feb;56(2):163-7)	""	0	#FFFFFF
D020295	C04.588.614.250.195.411.100|C10.228.140.211.500.100|C10.551.240.250.400.200	Brain Stem Neoplasms	Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.	""	0	#FFFFFF
D020299	C10.228.140.300.535.325|C14.907.253.573.350	Intracranial Hemorrhage, Hypertensive	Bleeding within the SKULL that is caused by systemic HYPERTENSION, usually in association with INTRACRANIAL ARTERIOSCLEROSIS. Hypertensive hemorrhages are most frequent in the BASAL GANGLIA; CEREBELLUM; PONS; and THALAMUS; but may also involve the CEREBRAL CORTEX, subcortical white matter, and other brain structures.	""	0	#FFFFFF
D020300	C10.228.140.300.535|C14.907.253.573|C23.550.414.913	Intracranial Hemorrhages	Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.	""	0	#FFFFFF
D020301	C10.228.140.300.900|C14.907.253.951	Vasospasm, Intracranial	Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).	""	0	#FFFFFF
D020306	C01.150.252.223.850|C01.150.252.410.040.552.846.570|C01.207.180.850|C10.228.228.180.850	Tuberculosis, Central Nervous System	Tuberculosis of the brain, spinal cord, or meninges (TUBERCULOSIS, MENINGEAL), most often caused by MYCOBACTERIUM TUBERCULOSIS and rarely by MYCOBACTERIUM BOVIS. The infection may be limited to the nervous system or coexist in other organs (e.g., TUBERCULOSIS, PULMONARY). The organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of TUBERCULOMA, which may occur within the brain, spinal cord, or perimeningeal spaces. Tuberculous involvement of the vertebral column (TUBERCULOSIS, SPINAL) may result in nerve root or spinal cord compression. (From Adams et al., Principles of Neurology, 6th ed, pp717-20)	""	0	#FFFFFF
D020314	C01.150.703.181|C01.207.198|C10.228.228.198	Central Nervous System Fungal Infections	MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).	""	0	#FFFFFF
D020315	C20.543.600	Latex Hypersensitivity	Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.	""	0	#FFFFFF
D020323	C10.597.350.700|C23.888.592.350.700	Tics	Habitual, repeated, rapid contraction of certain muscles, resulting in stereotyped individualized actions that can be voluntarily suppressed for only brief periods. They often involve the face, vocal cords, neck, and less often the extremities. Examples include repetitive throat clearing, vocalizations, sniffing, pursing the lips, and excessive blinking. Tics tend to be aggravated by emotional stress. When frequent they may interfere with speech and INTERPERSONAL RELATIONS. Conditions which feature frequent and prominent tics as a primary manifestation of disease are referred to as TIC DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, pp109-10)	""	0	#FFFFFF
D020324	C10.597.606.525.100.075|C23.888.592.604.529.100.075	Amnesia, Anterograde	Loss of the ability to form new memories beyond a certain point in time. This condition may be organic or psychogenic in origin. Organically induced anterograde amnesia may follow CRANIOCEREBRAL TRAUMA; SEIZURES; ANOXIA; and other conditions which adversely affect neural structures associated with memory formation (e.g., the HIPPOCAMPUS; FORNIX (BRAIN); MAMMILLARY BODIES; and ANTERIOR THALAMIC NUCLEI). (From Memory 1997 Jan-Mar;5(1-2):49-71)	""	0	#FFFFFF
D020325	C10.228.140.546.399.750.250	Migraine with Aura	A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	""	0	#FFFFFF
D020326	C10.228.140.546.399.750.450	Migraine without Aura	Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	""	0	#FFFFFF
D020329	C10.228.662.350	Essential Tremor	A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)	""	0	#FFFFFF
D020330	C01.925.256.466.087|C07.465.094|C07.465.299.250|C10.292.319.250	Bell Palsy	A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376)	""	0	#FFFFFF
D020331	C07.465.299.825|C10.292.319.825|C16.131.077.578|C16.614.595	Mobius Syndrome	A syndrome of congenital facial paralysis, frequently associated with abducens palsy and other congenital abnormalities including lingual palsy, clubfeet, brachial disorders, cognitive deficits, and pectoral muscle defects. Pathologic findings are variable and include brain stem nuclear aplasia, facial nerve aplasia, and facial muscle aplasia, consistent with a multifactorial etiology. (Adams et al., Principles of Neurology, 6th ed, p1020)	""	0	#FFFFFF
D020333	C10.292.562.900|C11.590.905	Tolosa-Hunt Syndrome	An idiopathic syndrome characterized by the formation of granulation tissue in the anterior cavernous sinus or superior orbital fissure, producing a painful ophthalmoplegia. (Adams et al., Principles of Neurology, 6th ed, p271)	""	0	#FFFFFF
D020335	C10.597.636.500|C23.888.592.643.500	Paraparesis	Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.	""	0	#FFFFFF
D020336	C10.597.636.500.500|C23.888.592.643.500.500	Paraparesis, Spastic	Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.	""	0	#FFFFFF
D020338	C09.218.807.800.837|C10.292.910.850	Vestibular Neuronitis	Idiopathic inflammation of the VESTIBULAR NERVE, characterized clinically by the acute or subacute onset of VERTIGO; NAUSEA; and imbalance. The COCHLEAR NERVE is typically spared and HEARING LOSS and TINNITUS do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304)	""	0	#FFFFFF
D020339	C04.557.465.625.600.380.795|C04.557.470.670.380.795|C04.557.580.625.600.380.795|C04.588.614.300.600.600|C04.588.614.596.240.240.500|C10.292.225.800.500|C10.292.700.500.500|C10.551.360.500.500|C10.551.775.250.500.500|C11.640.544.500	Optic Nerve Glioma	Glial cell derived tumors arising from the optic nerve, usually presenting in childhood.	""	0	#FFFFFF
D020343	C10.228.140.631.500	Hypertensive Encephalopathy	Brain dysfunction or damage resulting from sustained MALIGNANT HYPERTENSION. When BLOOD PRESSURE exceeds the limits of cerebral autoregulation, cerebral blood flow is impaired (BRAIN ISCHEMIA). Clinical manifestations include HEADACHE; NAUSEA; VOMITING; SEIZURES; altered mental status (in some cases progressing to COMA); PAPILLEDEMA; and RETINAL HEMORRHAGE.	""	0	#FFFFFF
D020345	C06.405.205.596.700|C06.405.469.363.700	Enterocolitis, Necrotizing	ENTEROCOLITIS with extensive ulceration (ULCER) and NECROSIS. It is observed primarily in LOW BIRTH WEIGHT INFANT.	""	0	#FFFFFF
D020347	C23.550.537	Lithiasis	A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.	""	0	#FFFFFF
D020361	C04.588.614.550|C04.730.856|C10.574.781	Paraneoplastic Syndromes, Nervous System	Degenerative or inflammatory conditions affecting the central or peripheral nervous system that develop in association with a systemic neoplasm without direct invasion by tumor. They may be associated with circulating antibodies that react with the affected neural tissue. (Intern Med 1996 Dec;35(12):925-9)	""	0	#FFFFFF
D020362	C04.588.614.550.650|C04.730.856.650|C10.228.140.252.620|C10.574.781.700	Paraneoplastic Cerebellar Degeneration	Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)	""	0	#FFFFFF
D020363	C01.207.245.700|C04.588.614.550.450|C04.730.856.437|C10.228.140.430.525|C10.228.228.245.700|C10.574.781.550|C10.586.250.525	Limbic Encephalitis	A paraneoplastic syndrome marked by degeneration of neurons in the LIMBIC SYSTEM. Clinical features include HALLUCINATIONS, loss of EPISODIC MEMORY; ANOSMIA; AGEUSIA; TEMPORAL LOBE EPILEPSY; DEMENTIA; and affective disturbance (depression). Circulating anti-neuronal antibodies (e.g., anti-Hu; anti-Yo; anti-Ri; and anti-Ma2) and small cell lung carcinomas or testicular carcinoma are frequently associated with this syndrome.	""	0	#FFFFFF
D020364	C04.588.614.550.700|C04.730.856.700|C10.574.781.850|C10.668.829.800.662	Paraneoplastic Polyneuropathy	A diffuse or multifocal peripheral neuropathy related to the remote effects of a neoplasm, most often carcinoma or lymphoma. Pathologically, there are inflammatory changes in peripheral nerves. The most common clinical presentation is a symmetric distal mixed sensorimotor polyneuropathy. (Adams et al., Principles of Neurology, 6th ed, p1334)	""	0	#FFFFFF
D020370	C05.550.114.606.500|C05.799.613.500	Osteoarthritis, Knee	Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)	""	0	#FFFFFF
D020371	C10.228.140.163.100.362.775|C10.228.140.695.625.775|C10.314.400.775|C16.320.322.906|C16.320.565.189.362.775|C18.452.132.100.362.775|C18.452.648.189.362.775	Pelizaeus-Merzbacher Disease	A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190)	""	0	#FFFFFF
D020385	C10.597.613.650|C23.888.592.608.650	Myokymia	Successive and rapid contractions of motor units associated with chronic nerve injury. The discharges arise from the peripheral aspects of regenerating nerves, and clinically impart a nearly continuous undulation of the body surface overlying the muscle. (Adams et al., Principles of Neurology, 6th ed, p1491)	""	0	#FFFFFF
D020386	C05.651.392|C10.668.829.425	Isaacs Syndrome	A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)	""	0	#FFFFFF
D020388	C05.651.534.500.300|C10.668.491.175.500.300|C16.320.322.562|C16.320.577.300	Muscular Dystrophy, Duchenne	An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)	""	0	#FFFFFF
D020389	C05.651.534.500.350|C10.668.491.175.500.350|C16.320.322.625|C16.320.577.350	Muscular Dystrophy, Emery-Dreifuss	A heterogenous group of inherited muscular dystrophy without the involvement of nervous system. The disease is characterized by MUSCULAR ATROPHY; MUSCLE WEAKNESS; CONTRACTURE of the elbows; ACHILLES TENDON; and posterior cervical muscles; with or without cardiac features. There are several INHERITANCE PATTERNS including X-linked (X CHROMOSOME), autosomal dominant (for LMNA-associated type see AUTOSOMAL EMERY-DREIFUSS MUSCULAR DYSTROPHY), and autosomal recessive gene mutations.	""	0	#FFFFFF
D020391	C05.651.534.500.400|C10.668.491.175.500.400|C16.320.577.400	Muscular Dystrophy, Facioscapulohumeral	An autosomal dominant degenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation. This tends to be followed by facial weakness, primarily involving the orbicularis oris and orbicularis oculi muscles. (Neuromuscul Disord 1997;7(1):55-62; Adams et al., Principles of Neurology, 6th ed, p1420)	""	0	#FFFFFF
D020417	C10.292.562.675.300|C11.590.400.300|C16.614.643	Nystagmus, Congenital	Nystagmus present at birth or caused by lesions sustained in utero or at the time of birth. It is usually pendular, and is associated with ALBINISM and conditions characterized by early loss of central vision. Inheritance patterns may be X-linked, autosomal dominant, or recessive. (Adams et al., Principles of Neurology, 6th ed, p275)	""	0	#FFFFFF
D020421	C10.292.887	Vagus Nerve Diseases	Diseases of the tenth cranial nerve, including brain stem lesions involving its nuclei (solitary, ambiguus, and dorsal motor), nerve fascicles, and intracranial and extracranial course. Clinical manifestations may include dysphagia, vocal cord weakness, and alterations of parasympathetic tone in the thorax and abdomen.	""	0	#FFFFFF
D020422	C10.668.829.500	Mononeuropathies	Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ISCHEMIA; traumatic injury; compression; CONNECTIVE TISSUE DISEASES; CUMULATIVE TRAUMA DISORDERS; and other conditions.	""	0	#FFFFFF
D020423	C10.668.829.500.500	Median Neuropathy	Disease involving the median nerve, from its origin at the BRACHIAL PLEXUS to its termination in the hand. Clinical features include weakness of wrist and finger flexion, forearm pronation, thenar abduction, and loss of sensation over the lateral palm, first three fingers, and radial half of the ring finger. Common sites of injury include the elbow, where the nerve passes through the two heads of the pronator teres muscle (pronator syndrome) and in the carpal tunnel (CARPAL TUNNEL SYNDROME).	""	0	#FFFFFF
D020424	C10.668.829.500.850	Ulnar Neuropathies	Disease involving the ULNAR NERVE from its origin in the BRACHIAL PLEXUS to its termination in the hand. Clinical manifestations may include PARESIS or PARALYSIS of wrist flexion, finger flexion, thumb adduction, finger abduction, and finger adduction. Sensation over the medial palm, fifth finger, and ulnar aspect of the ring finger may also be impaired. Common sites of injury include the AXILLA, cubital tunnel at the ELBOW, and Guyon's canal at the wrist. (From Joynt, Clinical Neurology, 1995, Ch51 pp43-5)	""	0	#FFFFFF
D020425	C10.668.829.500.650	Radial Neuropathy	Disease involving the RADIAL NERVE. Clinical features include weakness of elbow extension, elbow flexion, supination of the forearm, wrist and finger extension, and thumb abduction. Sensation may be impaired over regions of the dorsal forearm. Common sites of compression or traumatic injury include the AXILLA and radial groove of the HUMERUS.	""	0	#FFFFFF
D020426	C10.668.829.500.675	Sciatic Neuropathy	Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)	""	0	#FFFFFF
D020427	C10.668.829.500.600	Peroneal Neuropathies	Disease involving the common PERONEAL NERVE or its branches, the deep and superficial peroneal nerves. Lesions of the deep peroneal nerve are associated with PARALYSIS of dorsiflexion of the ankle and toes and loss of sensation from the web space between the first and second toe. Lesions of the superficial peroneal nerve result in weakness or paralysis of the peroneal muscles (which evert the foot) and loss of sensation over the dorsal and lateral surface of the leg. Traumatic injury to the common peroneal nerve near the head of the FIBULA is a relatively common cause of this condition. (From Joynt, Clinical Neurology, 1995, Ch51, p31)	""	0	#FFFFFF
D020428	C10.668.829.500.200	Femoral Neuropathy	Disease involving the femoral nerve. The femoral nerve may be injured by ISCHEMIA (e.g., in association with DIABETIC NEUROPATHIES), nerve compression, trauma, COLLAGEN DISEASES, and other disease processes. Clinical features include MUSCLE WEAKNESS or PARALYSIS of hip flexion and knee extension, ATROPHY of the QUADRICEPS MUSCLE, reduced or absent patellar reflex, and impaired sensation over the anterior and medial thigh.	""	0	#FFFFFF
D020429	C10.668.829.500.700	Tibial Neuropathy	Disease of the TIBIAL NERVE (also referred to as the posterior tibial nerve). The most commonly associated condition is the TARSAL TUNNEL SYNDROME. However, LEG INJURIES; ISCHEMIA; and inflammatory conditions (e.g., COLLAGEN DISEASES) may also affect the nerve. Clinical features include PARALYSIS of plantar flexion, ankle inversion and toe flexion as well as loss of sensation over the sole of the foot. (From Joynt, Clinical Neurology, 1995, Ch51, p32)	""	0	#FFFFFF
D020430	C10.668.829.500.850.200|C10.668.829.550.925.200|C26.844.150.957.200	Cubital Tunnel Syndrome	Compression of the ULNAR NERVE in the cubital tunnel, which is formed by the two heads of the flexor carpi ulnaris muscle, humeral-ulnar aponeurosis, and medial ligaments of the elbow. This condition may follow trauma or occur in association with processes which produce nerve enlargement or narrowing of the canal. Manifestations include elbow pain and PARESTHESIA radiating distally, weakness of ulnar innervated intrinsic hand muscles, and loss of sensation over the hypothenar region, fifth finger, and ulnar aspect of the ring finger. (Joynt, Clinical Neurology, 1995, Ch51, p43)	""	0	#FFFFFF
D020431	C10.292.650	Olfactory Nerve Diseases	Diseases of the first cranial (olfactory) nerve, which usually feature anosmia or other alterations in the sense of smell and taste. Anosmia may be associated with NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; CRANIOCEREBRAL TRAUMA; inherited conditions; toxins; METABOLIC DISEASES; tobacco abuse; and other conditions. (Adams et al., Principles of Neurology, 6th ed, pp229-31)	""	0	#FFFFFF
D020432	C10.292.850	Trochlear Nerve Diseases	Diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.	""	0	#FFFFFF
D020433	C07.465.299.625.500|C10.292.319.625.700	Trigeminal Nerve Diseases	Diseases of the trigeminal nerve or its nuclei, which are located in the pons and medulla. The nerve is composed of three divisions: ophthalmic, maxillary, and mandibular, which provide sensory innervation to structures of the face, sinuses, and portions of the cranial vault. The mandibular nerve also innervates muscles of mastication. Clinical features include loss of facial and intra-oral sensation and weakness of jaw closure. Common conditions affecting the nerve include brain stem ischemia, INFRATENTORIAL NEOPLASMS, and TRIGEMINAL NEURALGIA.	""	0	#FFFFFF
D020434	C10.292.150	Abducens Nerve Diseases	Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.	""	0	#FFFFFF
D020435	C10.292.450	Glossopharyngeal Nerve Diseases	Diseases of the ninth cranial (glossopharyngeal) nerve or its nuclei in the medulla. The nerve may be injured by diseases affecting the lower brain stem, floor of the posterior fossa, jugular foramen, or the nerve's extracranial course. Clinical manifestations include loss of sensation from the pharynx, decreased salivation, and syncope. Glossopharyngeal neuralgia refers to a condition that features recurrent unilateral sharp pain in the tongue, angle of the jaw, external auditory meatus and throat that may be associated with SYNCOPE. Episodes may be triggered by cough, sneeze, swallowing, or pressure on the tragus of the ear. (Adams et al., Principles of Neurology, 6th ed, p1390)	""	0	#FFFFFF
D020436	C10.292.175	Accessory Nerve Diseases	Diseases of the eleventh cranial (spinal accessory) nerve. This nerve originates from motor neurons in the lower medulla (accessory portion of nerve) and upper spinal cord (spinal portion of nerve). The two components of the nerve join and exit the skull via the jugular foramen, innervating the sternocleidomastoid and trapezius muscles, which become weak or paralyzed if the nerve is injured. The nerve is commonly involved in MOTOR NEURON DISEASE, and may be injured by trauma to the posterior triangle of the neck.	""	0	#FFFFFF
D020437	C10.292.525	Hypoglossal Nerve Diseases	Diseases of the twelfth cranial (hypoglossal) nerve or nuclei. The nuclei and fascicles of the nerve are located in the medulla, and the nerve exits the skull via the hypoglossal foramen and innervates the muscles of the tongue. Lower brain stem diseases, including ischemia and MOTOR NEURON DISEASES may affect the nuclei or nerve fascicles. The nerve may also be injured by diseases of the posterior fossa or skull base. Clinical manifestations include unilateral weakness of tongue musculature and lingual dysarthria, with deviation of the tongue towards the side of weakness upon attempted protrusion.	""	0	#FFFFFF
D020447	C10.886.659	Parasomnias	Movements or behaviors associated with sleep, sleep stages, or partial arousals from sleep that may impair sleep maintenance. Parasomnias are generally divided into four groups: arousal disorders, sleep-wake transition disorders, parasomnias of REM sleep, and nonspecific parasomnias. (From Thorpy, Sleep Disorders Medicine, 1994, p191)	""	0	#FFFFFF
D020511	C10.668.758	Neuromuscular Junction Diseases	Conditions characterized by impaired transmission of impulses at the NEUROMUSCULAR JUNCTION. This may result from disorders that affect receptor function, pre- or postsynaptic membrane function, or ACETYLCHOLINESTERASE activity. The majority of diseases in this category are associated with autoimmune, toxic, or inherited conditions.	""	0	#FFFFFF
D020512	C05.651.575.300|C10.668.491.550.300	Myopathy, Central Core	An inherited congenital myopathic condition characterized by weakness and hypotonia in infancy and delayed motor development. Muscle biopsy reveals a condensation of myofibrils and myofibrillar material in the central portion of each muscle fiber. (Adams et al., Principles of Neurology, 6th ed, p1452)	""	0	#FFFFFF
D020513	C05.651.701.600|C10.668.491.650.600|C16.320.565.618.711.600|C18.452.648.618.711.600	Paralysis, Hyperkalemic Periodic	An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)	""	0	#FFFFFF
D020514	C05.651.701.450|C10.668.491.650.450|C16.320.565.618.711.550|C18.452.648.618.711.550	Hypokalemic Periodic Paralysis	An autosomal dominant familial disorder characterized by recurrent episodes of skeletal muscle weakness associated with falls in serum potassium levels. The condition usually presents in the first or second decade of life with attacks of trunk and leg paresis during sleep or shortly after awakening. Symptoms may persist for hours to days and generally are precipitated by exercise or a meal high in carbohydrates. (Adams et al., Principles of Neurology, 6th ed, p1483)	""	0	#FFFFFF
D020516	C10.668.829.100	Brachial Plexus Neuropathies	Diseases of the cervical (and first thoracic) roots, nerve trunks, cords, and peripheral nerve components of the BRACHIAL PLEXUS. Clinical manifestations include regional pain, PARESTHESIA; MUSCLE WEAKNESS, and decreased sensation (HYPESTHESIA) in the upper extremity. These disorders may be associated with trauma (including BIRTH INJURIES); THORACIC OUTLET SYNDROME; NEOPLASMS; NEURITIS; RADIOTHERAPY; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp1351-2)	""	0	#FFFFFF
D020518	C06.552.270	Focal Nodular Hyperplasia	Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. The pale colored central scar represents large blood vessels with hyperplastic fibromuscular layer and narrowing lumen.	""	0	#FFFFFF
D020520	C10.228.140.300.150.477|C10.228.140.300.775.200|C14.907.253.092.477|C14.907.253.855.200|C23.550.513.355.250|C23.550.717.489.250	Brain Infarction	Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.	""	0	#FFFFFF
D020521	C10.228.140.300.775|C14.907.253.855	Stroke	A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)	""	0	#FFFFFF
D020522	C04.557.386.480.525|C15.604.515.569.480.525|C20.683.515.761.480.525	Lymphoma, Mantle-Cell	A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).	""	0	#FFFFFF
D020526	C10.228.140.300.150.477.100|C10.228.140.300.775.200.100|C14.907.253.092.477.100|C14.907.253.855.200.100|C23.550.513.355.250.100|C23.550.717.489.250.100	Brain Stem Infarctions	Infarctions that occur in the BRAIN STEM which is comprised of the MIDBRAIN; PONS; and MEDULLA OBLONGATA. There are several named syndromes characterized by their distinctive clinical manifestations and specific sites of ischemic injury.	""	0	#FFFFFF
D020528	C10.114.375.500.200|C10.314.350.500.200|C20.111.258.250.500.200|C23.550.291.500.625	Multiple Sclerosis, Chronic Progressive	A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)	""	0	#FFFFFF
D020529	C10.114.375.500.600|C10.314.350.500.600|C20.111.258.250.500.600	Multiple Sclerosis, Relapsing-Remitting	The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914)	""	0	#FFFFFF
D020567	C23.888.144.300	Fetal Weight	The weight of the FETUS in utero. It is usually estimated by various formulas based on measurements made during PRENATAL ULTRASONOGRAPHY.	""	0	#FFFFFF
D020642	C16.320.565.663.050|C18.452.648.663.050	Acatalasia	A rare autosomal recessive disorder resulting from the absence of CATALASE activity. Though usually asymptomatic, a syndrome of oral ulcerations and gangrene may be present.	""	0	#FFFFFF
D020720	C10.114.656.300|C10.114.703.350|C10.668.758.725.300|C20.111.258.500.300|C20.111.258.625.350	Myasthenia Gravis, Autoimmune, Experimental	Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)	""	0	#FFFFFF
D020721	C10.114.703|C20.111.258.625	Nervous System Autoimmune Disease, Experimental	Experimental animal models for human AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM. They include GUILLAIN-BARRE SYNDROME (see NEURITIS, AUTOIMMUNE, EXPERIMENTAL); MYASTHENIA GRAVIS (see MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL); and MULTIPLE SCLEROSIS (see ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL).	""	0	#FFFFFF
D020734	C10.228.140.079.862|C10.228.662.600	Parkinsonian Disorders	A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.	""	0	#FFFFFF
D020739	C10.228.140.163.100|C16.320.565.189|C18.452.132.100|C18.452.648.189	Brain Diseases, Metabolic, Inborn	Brain disorders resulting from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. The majority of these conditions are familial, however spontaneous mutation may also occur in utero.	""	0	#FFFFFF
D020751	C25.775.100.087	Alcohol-Induced Disorders	Disorders stemming from the misuse and abuse of alcohol.	""	0	#FFFFFF
D020752	C10.562|C16.131.077.350.712|C16.131.831.350.712|C16.320.850.250.712|C17.800.804.350.712|C17.800.827.250.712	Neurocutaneous Syndromes	A group of disorders characterized by ectodermal-based malformations and neoplastic growths in the skin, nervous system, and other organs.	""	0	#FFFFFF
D020754	C10.228.140.252.190.530|C10.228.140.252.700.700|C10.228.854.787.875|C10.574.500.825.700|C10.597.350.090.500.530|C16.320.400.780.875	Spinocerebellar Ataxias	A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)	""	0	#FFFFFF
D020757	C10.597.751.941.162.125|C11.966.075.125|C23.888.592.763.941.162.125	Amaurosis Fugax	Transient complete or partial monocular blindness due to retinal ischemia. This may be caused by emboli from the CAROTID ARTERY (usually in association with CAROTID STENOSIS) and other locations that enter the central RETINAL ARTERY. (From Adams et al., Principles of Neurology, 6th ed, p245)	""	0	#FFFFFF
D020758	C10.228.854.785|C14.907.790	Spinal Cord Vascular Diseases	Pathological processes involving any of the BLOOD VESSELS feeding the SPINAL CORD, such as the anterior and paired posterior spinal arteries or their many branches. Disease processes may include ATHEROSCLEROSIS; EMBOLISM; and ARTERIOVENOUS MALFORMATIONS leading to ISCHEMIA or HEMORRHAGE into the spinal cord (hematomyelia).	""	0	#FFFFFF
D020759	C10.228.854.785.650.100|C14.907.790.550.100	Anterior Spinal Artery Syndrome	Ischemia or infarction of the spinal cord in the distribution of the anterior spinal artery, which supplies the ventral two-thirds of the spinal cord. This condition is usually associated with ATHEROSCLEROSIS of the aorta and may result from dissection of an AORTIC ANEURYSM or rarely dissection of the anterior spinal artery. Clinical features include weakness and loss of pain and temperature sensation below the level of injury, with relative sparing of position and vibratory sensation. (From Adams et al., Principles of Neurology, 6th ed, pp1249-50)	""	0	#FFFFFF
D020760	C10.228.854.785.650|C14.907.790.550	Spinal Cord Ischemia	Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.	""	0	#FFFFFF
D020762	C10.228.140.300.150.477.200.475|C10.228.140.300.510.200.418|C10.228.140.300.775.200.200.475|C14.907.253.092.477.200.475|C14.907.253.560.200.418|C14.907.253.855.200.200.475|C23.550.513.355.250.200.475|C23.550.717.489.250.200.475	Infarction, Posterior Cerebral Artery	NECROSIS induced by ISCHEMIA in the POSTERIOR CEREBRAL ARTERY distribution system which supplies portions of the BRAIN STEM; the THALAMUS; TEMPORAL LOBE, and OCCIPITAL LOBE. Depending on the size and location of infarction, clinical features include OLFACTION DISORDERS and visual problems (AGNOSIA; ALEXIA; HEMIANOPSIA).	""	0	#FFFFFF
D020763	C23.300	Pathological Conditions, Anatomical	An abnormal structural condition of the human body, usually macroscopic, that is common to a variety of different diseases.	""	0	#FFFFFF
D020765	C10.228.140.300.510|C14.907.253.560	Intracranial Arterial Diseases	Pathological conditions involving ARTERIES in the skull, such as arteries supplying the CEREBRUM, the CEREBELLUM, the BRAIN STEM, and associated structures. They include atherosclerotic, congenital, traumatic, infectious, inflammatory, and other pathological processes.	""	0	#FFFFFF
D020766	C10.228.140.300.525.400|C14.907.253.566.300|C14.907.355.590.213.300	Intracranial Embolism	Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.	""	0	#FFFFFF
D020767	C10.228.140.300.525.425|C14.907.253.566.350|C14.907.355.590.213.350	Intracranial Thrombosis	Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.	""	0	#FFFFFF
D020773	C10.228.140.546	Headache Disorders	Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	""	0	#FFFFFF
D020774	C10.228.140.380.266.299.500	Pick Disease of the Brain	A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)	""	0	#FFFFFF
D020779	C10.500.190.800|C14.240.850.875.750|C16.131.666.190.800	Sinus Pericranii	Rare vascular anomaly involving a communication between the intracranial and extracranial venous circulation via diploe, the central spongy layer of cranial bone. It is often characterized by dilated venous structures on the scalp due to abnormal drainage from the intracranial venous sinuses. Sinus pericranii can be congenital or traumatic in origin.	""	0	#FFFFFF
D020785	C10.500.190|C14.240.850.875|C16.131.240.850.875|C16.131.666.190	Central Nervous System Vascular Malformations	Congenital, inherited, or acquired abnormalities involving ARTERIES; VEINS; or venous sinuses in the BRAIN; SPINAL CORD; and MENINGES.	""	0	#FFFFFF
D020786	C04.557.645.375.385.500|C10.500.190.200|C14.240.850.875.249|C14.907.454.385.500|C15.378.463.515.385.500|C16.131.666.190.200	Hemangioma, Cavernous, Central Nervous System	A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.	""	0	#FFFFFF
D020787	C04.557.645.375.185|C10.500.190.100|C14.240.850.875.124|C16.131.666.190.100	Central Nervous System Venous Angioma	A vascular anomaly characterized by a radial or wedge-shaped arrangement of dilated VEINS draining into a larger vein in the brain, spinal cord, or the meninges. Veins in a venous angioma are surrounded by normal nervous tissue, unlike a CENTRAL NERVOUS SYSTEM CAVERNOUS HEMANGIOMA that lacks intervening nervous tissue. Drainage of venous angioma is fully integrated with the body's venous system, therefore, in most cases there is no clinical signs and rare bleeding.	""	0	#FFFFFF
D020788	C10.228.140.617.200|C11.270.684.624|C16.131.077.245.125|C16.320.184.125	Bardet-Biedl Syndrome	An autosomal recessive disorder characterized by RETINITIS PIGMENTOSA; POLYDACTYLY; OBESITY; MENTAL RETARDATION; hypogenitalism; renal dysplasia; and short stature. This syndrome has been distinguished as a separate entity from LAURENCE-MOON SYNDROME. (From J Med Genet 1997 Feb;34(2):92-8)	""	0	#FFFFFF
D020790	C12.050.351.968.419.135.750|C12.200.777.419.135.750|C12.950.419.135.750|C19.700.159.750	Diabetes Insipidus, Neurogenic	A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).	""	0	#FFFFFF
D020792	C07.465.815.497|C23.300.175.700	Salivary Calculi	The presence of calculi in a salivary duct or gland.	""	0	#FFFFFF
D020795	C10.597.751.941.661|C11.966.741|C23.888.592.763.941.661	Photophobia	Abnormal sensitivity to light. This may occur as a manifestation of EYE DISEASES; MIGRAINE; SUBARACHNOID HEMORRHAGE; MENINGITIS; and other disorders. Photophobia may also occur in association with DEPRESSION and other MENTAL DISORDERS.	""	0	#FFFFFF
D020802	C01.207.300|C01.207.709.350|C01.830.025.325|C10.228.228.300|C10.228.228.709.350|C10.228.854.303	Epidural Abscess	Circumscribed collections of suppurative material occurring in the spinal or intracranial EPIDURAL SPACE. The majority of epidural abscesses occur in the spinal canal and are associated with OSTEOMYELITIS of a vertebral body; ANALGESIA, EPIDURAL; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, URINARY INCONTINENCE, and FECAL INCONTINENCE. Cranial epidural abscesses are usually associated with OSTEOMYELITIS of a cranial bone, SINUSITIS, or OTITIS MEDIA. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12)	""	0	#FFFFFF
D020803	C01.207.245.340.350|C01.207.399.750.350|C01.925.182.525.350|C01.925.256.466.262|C10.228.140.430.520.750.350|C10.228.228.245.340.350|C10.228.228.399.750.350|C10.586.250.520.750.350	Encephalitis, Herpes Simplex	An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)	""	0	#FFFFFF
D020804	C01.207.245.340.400|C01.207.399.750.400|C01.925.182.525.400|C01.925.256.466.930.500|C10.228.140.430.520.750.400|C10.228.228.245.340.400|C10.228.228.399.750.400|C10.586.250.520.750.400	Encephalitis, Varicella Zoster	Inflammation of brain tissue caused by infection with the varicella-zoster virus (HERPESVIRUS 3, HUMAN). This condition is associated with immunocompromised states, including the ACQUIRED IMMUNODEFICIENCY SYNDROME. Pathologically, the virus tends to induce a vasculopathy and infect oligodendrocytes and ependymal cells, leading to CEREBRAL INFARCTION, multifocal regions of demyelination, and periventricular necrosis. Manifestations of varicella encephalitis usually occur 5-7 days after onset of HERPES ZOSTER and include HEADACHE; VOMITING; lethargy; focal neurologic deficits; FEVER; and COMA. (From Joynt, Clinical Neurology, 1996, Ch 26, pp29-32; Hum Pathol 1996 Sep;27(9):927-38)	""	0	#FFFFFF
D020805	C01.207.245|C01.925.182|C10.228.228.245	Central Nervous System Viral Diseases	Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.	""	0	#FFFFFF
D020806	C01.150.252.223|C01.207.180|C10.228.228.180	Central Nervous System Bacterial Infections	Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.	""	0	#FFFFFF
D020807	C01.207.205|C01.610.105|C10.228.228.205	Central Nervous System Parasitic Infections	Infections of the brain, spinal cord, and meninges caused by parasites.	""	0	#FFFFFF
D020808	C01.207.205.300|C01.610.105.300|C01.610.752.100|C10.228.228.205.300	Central Nervous System Protozoal Infections	Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.	""	0	#FFFFFF
D020809	C01.207.205.250|C01.610.105.250|C10.228.228.205.250	Central Nervous System Helminthiasis	Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).	""	0	#FFFFFF
D020814	C01.150.252.223.500.350|C01.150.252.400.310.330.500|C01.207.180.500.350|C10.228.228.180.500.350|C10.586.625.280.350	Meningitis, Escherichia coli	A form of gram-negative meningitis that tends to occur in neonates, in association with anatomical abnormalities (which feature communication between the meninges and cutaneous structures) or as OPPORTUNISTIC INFECTIONS in association with IMMUNOLOGIC DEFICIENCY SYNDROMES. In premature neonates the clinical presentation may be limited to ANOREXIA; VOMITING; lethargy; or respiratory distress. Full-term infants may have as additional features FEVER; SEIZURES; and bulging of the anterior fontanelle. (From Menkes, Textbook of Child Neurology, 5th ed, pp398-400)	""	0	#FFFFFF
D020818	C01.207.205.250.600|C01.610.105.250.600|C01.610.335.865.859.213|C01.920.922.213|C10.228.228.205.250.600	Neuroschistosomiasis	SCHISTOSOMIASIS of the brain, spinal cord, or meninges caused by infections with trematodes of the genus SCHISTOSOMA (primarily SCHISTOSOMA JAPONICUM; SCHISTOSOMA MANSONI; and SCHISTOSOMA HAEMATOBIUM in humans). S. japonicum infections of the nervous system may cause an acute meningoencephalitis or a chronic encephalopathy. S. mansoni and S. haematobium nervous system infections are associated with acute transverse myelitis involving the lower portions of the spinal cord. (From Joynt, Clinical Neurology, 1998, Ch27, pp61-2)	""	0	#FFFFFF
D020819	C01.207.709|C10.228.228.709	Perimeningeal Infections	Infectious processes, including abscesses, effusions, and empyemas which occur in the epidural or subdural spaces surrounding the brain and spinal cord.	""	0	#FFFFFF
D020820	C10.228.662.262|C10.597.350|C23.888.592.350	Dyskinesias	Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underlying disease process. Conditions which feature recurrent or persistent episodes of dyskinesia as a primary manifestation of disease may be referred to as dyskinesia syndromes (see MOVEMENT DISORDERS). Dyskinesias are also a relatively common manifestation of BASAL GANGLIA DISEASES.	""	0	#FFFFFF
D020821	C10.228.662.300	Dystonic Disorders	Acquired and inherited conditions that feature DYSTONIA as a primary manifestation of disease. These disorders are generally divided into generalized dystonias (e.g., dystonia musculorum deformans) and focal dystonias (e.g., writer's cramp). They are also classified by patterns of inheritance and by age of onset.	""	0	#FFFFFF
D020828	C10.597.622.714|C23.888.592.636.711	Pseudobulbar Palsy	A syndrome characterized by DYSARTHRIA, dysphagia, dysphonia, impairment of voluntary movements of tongue and facial muscles, and emotional lability. This condition is caused by diseases that affect the motor fibers that travel from the cerebral cortex to the lower BRAIN STEM (i.e., corticobulbar tracts); including MULTIPLE SCLEROSIS; MOTOR NEURON DISEASE; and CEREBROVASCULAR DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p489)	""	0	#FFFFFF
D020833	C10.228.140.199.388.500|C10.900.300.087.219.500|C26.915.300.200.188.500	Diffuse Axonal Injury	A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.	""	0	#FFFFFF
D020852	C01.150.252.223.437|C01.150.252.400.536.700|C01.150.252.400.794.352.250.700|C01.207.180.437|C01.920.930.513.700|C10.228.228.180.437	Lyme Neuroborreliosis	Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91)	""	0	#FFFFFF
D020857	C05.330.488.300|C05.550.445|C26.558.300.500	Hallux Limitus	A bony proliferation and articular degeneration of the first METATARSOPHALANGEAL JOINT that is characterized by pain and a progressive decrease in the dorsiflexion range of motion.	""	0	#FFFFFF
D020859	C05.330.488.310|C05.550.450	Hallux Rigidus	A condition caused by degenerative arthritis (see OSTEOARTHRITIS) of the METATARSOPHALANGEAL JOINT of the great toe and characterized by pain and limited dorsiflexion, but relatively unrestricted plantar flexion.	""	0	#FFFFFF
D020863	C04.588.614.250.387|C10.500.142|C10.551.240.375|C16.131.666.142	Central Nervous System Cysts	Congenital or acquired cysts of the brain, spinal cord, or meninges which may remain stable in size or undergo progressive enlargement.	""	0	#FFFFFF
D020879	C10.597.613|C23.888.592.608	Neuromuscular Manifestations	Signs and symptoms associated with diseases of the muscle, neuromuscular junction, or peripheral nerves.	""	0	#FFFFFF
D020886	C10.597.751.791|C23.888.592.763.770	Somatosensory Disorders	Disorders of sensory information received from superficial and deep regions of the body. The somatosensory system conveys neural impulses which pertain to proprioception, tactile sensation, thermal sensation, pressure sensation, and pain. PERIPHERAL NERVOUS SYSTEM DISEASES; SPINAL CORD DISEASES; and BRAIN DISEASES may be associated with impaired or abnormal somatic sensation.	""	0	#FFFFFF
D020896	C23.550.455	Hypovolemia	An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK).	""	0	#FFFFFF
D020914	C05.651.575|C10.668.491.550	Myopathies, Structural, Congenital	A heterogeneous group of diseases characterized by the early onset of hypotonia, developmental delay of motor skills, non-progressive weakness. Each of these disorders is associated with a specific histologic muscle fiber abnormality.	""	0	#FFFFFF
D020915	C10.597.606.525.400|C23.888.592.604.529.400	Korsakoff Syndrome	An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is frequently associated with chronic ALCOHOLISM; but it may also result from dietary deficiencies; CRANIOCEREBRAL TRAUMA; NEOPLASMS; CEREBROVASCULAR DISORDERS; ENCEPHALITIS; EPILEPSY; and other conditions. (Adams et al., Principles of Neurology, 6th ed, p1139)	""	0	#FFFFFF
D020918	C10.177.195|C10.668.829.250	Complex Regional Pain Syndromes	Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)	""	0	#FFFFFF
D020919	C10.886.425.800	Sleep Disorders, Intrinsic	Dyssomnias (i.e., insomnias or hypersomnias) associated with dysfunction of internal sleep mechanisms or secondary to a sleep-related medical disorder (e.g., sleep apnea, post-traumatic sleep disorders, etc.). (From Thorpy, Sleep Disorders Medicine, 1994, p187)	""	0	#FFFFFF
D020920	C10.886.425	Dyssomnias	A broad category of sleep disorders characterized by either hypersomnolence or insomnia. The three major subcategories include intrinsic (i.e., arising from within the body) (SLEEP DISORDERS, INTRINSIC), extrinsic (secondary to environmental conditions or various pathologic conditions), and disturbances of circadian rhythm. (From Thorpy, Sleep Disorders Medicine, 1994, p187)	""	0	#FFFFFF
D020921	C10.886.659.635	Sleep Arousal Disorders	Sleep disorders characterized by impaired arousal from the deeper stages of sleep (generally stage III or IV sleep).	""	0	#FFFFFF
D020922	C10.886.659.700	Sleep-Wake Transition Disorders	Parasomnias characterized by behavioral abnormalities that occur during the transition between wakefulness and sleep (or between sleep and wakefulness).	""	0	#FFFFFF
D020923	C10.886.659.633	REM Sleep Parasomnias	Abnormal behavioral or physiologic events that are associated with REM sleep, including REM SLEEP BEHAVIOR DISORDER.	""	0	#FFFFFF
D020924	C23.888.942	Urological Manifestations	Clinical disturbances of the urinary system.	""	0	#FFFFFF
D020925	C10.228.140.300.150.716|C10.228.140.624.500|C14.907.253.092.716|C23.888.852.079.797.500	Hypoxia-Ischemia, Brain	A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.	""	0	#FFFFFF
D020936	C10.228.140.490.370|C16.614.258	Epilepsy, Benign Neonatal	A condition marked by recurrent seizures that occur during the first 4-6 weeks of life despite an otherwise benign neonatal course. Autosomal dominant familial and sporadic forms have been identified. Seizures generally consist of brief episodes of tonic posturing and other movements, apnea, eye deviations, and blood pressure fluctuations. These tend to remit after the 6th week of life. The risk of developing epilepsy at an older age is moderately increased in the familial form of this disorder. (Neurologia 1996 Feb;11(2):51-5)	""	0	#FFFFFF
D020937	C10.228.140.490.360.275	Epilepsy, Partial, Sensory	A disorder characterized by recurrent focal onset seizures which have sensory (i.e., olfactory, visual, tactile, gustatory, or auditory) manifestations. Partial seizures that feature alterations of consciousness are referred to as complex partial seizures (EPILEPSY, COMPLEX PARTIAL).	""	0	#FFFFFF
D020938	C10.228.140.490.360.272	Epilepsy, Partial, Motor	A disorder characterized by recurrent localized paroxysmal discharges of cerebral neurons that give rise to seizures that have motor manifestations. The majority of partial motor seizures originate in the FRONTAL LOBE (see also EPILEPSY, FRONTAL LOBE). Motor seizures may manifest as tonic or clonic movements involving the face, one limb or one side of the body. A variety of more complex patterns of movement, including abnormal posturing of extremities, may also occur.	""	0	#FFFFFF
D020941	C10.114.656.650|C10.668.758.725.650|C20.111.258.500.650	Myasthenia Gravis, Neonatal	A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4)	""	0	#FFFFFF
D020943	C01.221.250.875.048|C01.221.812.640.400.048|C01.778.640.400.048|C01.925.782.815.616.400.048|C01.925.813.400.048|C10.114.875.175|C10.228.140.300.850.125|C12.100.937.640.400.048|C14.907.253.946.175|C14.907.940.090.170|C14.907.940.907.175|C20.673.480.048	AIDS Arteritis, Central Nervous System	Inflammation of ARTERIES in the CENTRAL NERVOUS SYSTEM that occurs in patients with ACQUIRED IMMUNODEFICIENCY SYNDROME or AIDS-RELATED OPPORTUNISTIC INFECTIONS.	""	0	#FFFFFF
D020945	C01.207.245.550.500|C01.207.570.450|C10.114.875.850|C10.228.140.300.850.750|C10.228.140.430.550.500|C10.228.228.245.550.500|C10.228.228.570.450|C10.586.250.550.500|C10.586.625.500.500|C14.907.253.946.850|C14.907.940.907.850|C17.300.480.750|C20.111.258.962.900|C20.111.590.750	Lupus Vasculitis, Central Nervous System	Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.	""	0	#FFFFFF
D020953	C01.150.703.080.537|C01.150.703.492.750|C01.207.198.750|C10.228.228.198.750	Neuroaspergillosis	Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)	""	0	#FFFFFF
D020955	C10.177.575.550.875|C10.228.140.079.612.800|C10.228.662.550.800	Striatonigral Degeneration	A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)	""	0	#FFFFFF
D020961	C10.228.140.079.862.400|C10.228.140.380.422|C10.228.662.600.200|C10.574.928.500	Lewy Body Disease	A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)	""	0	#FFFFFF
D020964	C12.050.703.039.711|C23.550.260.440	Embryo Loss	Early pregnancy loss during the EMBRYO, MAMMALIAN stage of development. In the human, this period comprises the second through eighth week after fertilization.	""	0	#FFFFFF
D020966	C05.651.534|C10.668.491.175	Muscular Disorders, Atrophic	Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).	""	0	#FFFFFF
D020967	C05.651.662|C10.668.491.606	Myotonic Disorders	Diseases characterized by MYOTONIA, which may be inherited or acquired. Myotonia may be restricted to certain muscles (e.g., intrinsic hand muscles) or occur as a generalized condition.	""	0	#FFFFFF
D020968	C10.668.829.100.500|C10.668.829.650.250	Brachial Plexus Neuritis	A syndrome associated with inflammation of the BRACHIAL PLEXUS. Clinical features include severe pain in the shoulder region which may be accompanied by MUSCLE WEAKNESS and loss of sensation in the upper extremity. This condition may be associated with VIRUS DISEASES; IMMUNIZATION; SURGERY; heroin use (see HEROIN DEPENDENCE); and other conditions. The term brachial neuralgia generally refers to pain associated with brachial plexus injury. (From Adams et al., Principles of Neurology, 6th ed, pp1355-6)	""	0	#FFFFFF
D020969	C23.550.291	Disease Attributes	Clinical characteristics of disease or illness.	""	0	#FFFFFF
D021081	C10.281	Chronobiology Disorders	Disruptions of the rhythmic cycle of bodily functions or activities.	""	0	#FFFFFF
D021181	C20.543.480.370.150	Egg Hypersensitivity	Allergic reaction to eggs that is triggered by the immune system.	""	0	#FFFFFF
D021182	C20.543.480.370.850	Wheat Hypersensitivity	Allergic reaction to wheat that is triggered by the immune system.	""	0	#FFFFFF
D021183	C20.543.480.370.572.750	Peanut Hypersensitivity	Allergic reaction to peanuts that is triggered by the immune system.	""	0	#FFFFFF
D021184	C20.543.480.370.572.500	Nut Hypersensitivity	Allergic reaction to tree nuts that is triggered by the immune system.	""	0	#FFFFFF
D021441	C04.557.470.200.025.232.750|C04.557.470.615.132.750|C04.588.274.761.750|C04.588.322.475.750|C06.301.761.750|C06.689.667.625|C19.344.421.750	Carcinoma, Pancreatic Ductal	Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.	""	0	#FFFFFF
D021501	C23.888.592.612.386	Flank Pain	Pain emanating from below the RIBS and above the ILIUM.	""	0	#FFFFFF
D021782	C12.050.351.875.558|C12.050.351.968.419.403.750|C12.200.706.629|C12.200.777.419.403.750|C12.800.629|C12.950.419.403.750|C16.131.939.629	Multicystic Dysplastic Kidney	A nongenetic defect due to malformation of the KIDNEY which appears as a bunch of grapes with multiple renal cysts but lacking the normal renal bean shape, and the collection drainage system. This condition can be detected in-utero with ULTRASONOGRAPHY.	""	0	#FFFFFF
D021821	C01.221.500|C23.550.291.531.750	Communicable Diseases, Emerging	Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.	""	0	#FFFFFF
D021865	C01.610.752.250.410	Isosporiasis	Infection with parasitic protozoa of the genus ISOSPORA, producing intestinal disease. It is caused by ingestion of oocysts and can produce tissue cysts.	""	0	#FFFFFF
D021866	C01.610.752.250.280	Cyclosporiasis	Infection with parasitic protozoa of the genus CYCLOSPORA. It is distributed globally and causes a diarrheal illness. Transmission is waterborne.	""	0	#FFFFFF
D021921	C14.280.484.048.750.535|C14.280.955.249.535	Aortic Stenosis, Supravalvular	A pathological constriction occurring in the region above the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.	""	0	#FFFFFF
D021922	C14.280.484.048.750.070.210|C14.280.955.249.070.210	Discrete Subaortic Stenosis	A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the AORTIC VALVE, anywhere between the aortic valve and the MITRAL VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.	""	0	#FFFFFF
D022124	C23.550.421	Hyperammonemia	Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.	""	0	#FFFFFF
D022125	C26.540	Lacerations	Torn, ragged, mangled wounds.	""	0	#FFFFFF
D022861	C11.270.040.545.400|C15.378.100.100.515|C15.378.100.685.400|C15.378.140.735.400|C15.378.463.735.400|C16.320.099.515|C16.320.290.040.100.400|C16.320.565.100.102.100.400|C16.320.850.080.100.400|C17.800.621.440.102.100.400|C17.800.827.080.100.400|C18.452.648.100.102.100.400	Hermanski-Pudlak Syndrome	Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.	""	0	#FFFFFF
D023341	C23.888.208	Chills	The sudden sensation of being cold. It may be accompanied by SHIVERING.	""	0	#FFFFFF
D023521	C01.150.252.400.210.250	Chlamydophila Infections	Infections with bacteria of the genus CHLAMYDOPHILA.	""	0	#FFFFFF
D023903	C14.280.647.250.285.200|C14.907.585.250.285.200	Coronary Restenosis	Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.	""	0	#FFFFFF
D023921	C14.280.647.250.285|C14.907.585.250.285	Coronary Stenosis	Narrowing or constriction of a coronary artery.	""	0	#FFFFFF
D023961	C12.050.351.875.253.064.249|C12.050.351.875.253.309.193|C12.200.706.316.064.249|C12.200.706.316.309.193|C12.800.316.064.249|C12.800.316.309.193|C16.131.939.316.064.249|C16.131.939.316.309.193|C19.391.119.064.249|C19.391.119.309.193	Gonadal Dysgenesis, 46,XX	The 46,XX gonadal dysgenesis may be sporadic or familial. Familial XX gonadal dysgenesis is transmitted as an autosomal recessive trait and its locus was mapped to chromosome 2. Mutation in the gene for the FSH receptor (RECEPTORS, FSH) was detected. Sporadic XX gonadal dysgenesis is heterogeneous and has been associated with trisomy-13 and trisomy-18. These phenotypic females are characterized by a normal stature, sexual infantilism, bilateral streak gonads, amenorrhea, elevated plasma LUTEINIZING HORMONE and FSH concentration.	""	0	#FFFFFF
D023981	C04.557.337.539.775|C04.557.450.795.853	Sarcoma, Myeloid	An extramedullary tumor of immature MYELOID CELLS or MYELOBLASTS. Granulocytic sarcoma usually occurs with or follows the onset of ACUTE MYELOID LEUKEMIA.	""	0	#FFFFFF
D024182	C23.550.210.645.890	Uniparental Disomy	The presence in a cell of two paired chromosomes from the same parent, with no chromosome of that pair from the other parent. This chromosome composition stems from non-disjunction (NONDISJUNCTION, GENETIC) events during MEIOSIS. The disomy may be composed of both homologous chromosomes from one parent (heterodisomy) or a duplicate of one chromosome (isodisomy).	""	0	#FFFFFF
D024343	C07.793.494.825	Open Bite	A condition in which certain opposing teeth fail to establish occlusal contact when the jaws are closed.	""	0	#FFFFFF
D024741	C14.280.238.100.500|C14.280.484.048.750.070.160.500|C16.320.160	Cardiomyopathy, Hypertrophic, Familial	An autosomal dominant inherited form of HYPERTROPHIC CARDIOMYOPATHY. It results from any of more than 50 mutations involving genes encoding contractile proteins such as VENTRICULAR MYOSINS; cardiac TROPONIN T; ALPHA-TROPOMYOSIN.	""	0	#FFFFFF
D024801	C10.574.945	Tauopathies	Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.	""	0	#FFFFFF
D024821	C18.452.394.968.500.570|C18.452.625	Metabolic Syndrome	A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.	""	0	#FFFFFF
D025063	C16.131.260|C16.320.180	Chromosome Disorders	Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)	""	0	#FFFFFF
D025064	C16.131.260.830|C16.320.180.830	Sex Chromosome Disorders	Clinical conditions caused by an abnormal sex chromosome constitution (SEX CHROMOSOME ABERRATIONS), in which there is extra or missing sex chromosome material (either a whole chromosome or a chromosome segment).	""	0	#FFFFFF
D025241	C05.116.900.853.625|C05.550.114.865	Spondylarthritis	Inflammation of the joints of the SPINE, the intervertebral articulations.	""	0	#FFFFFF
D025242	C05.116.900.853.625.800|C05.550.114.865.800	Spondylarthropathies	Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.	""	0	#FFFFFF
D025861	C15.378.100.100|C16.320.099	Blood Coagulation Disorders, Inherited	Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.	""	0	#FFFFFF
D025962	C10.500.034.937|C10.500.760.500|C16.131.666.034.937|C16.131.666.763.500	Septo-Optic Dysplasia	A condition resulting from congenital malformations involving the brain. The syndrome of septo-optic dysplasia combines hypoplasia or agenesis of the SEPTUM PELLUCIDUM; CORPUS CALLOSUM and the OPTIC NERVE. The extent of the abnormalities can vary. Septo-optic dysplasia is often associated with abnormalities of the HYPOTHALAMUS and other diencephalic structures, and HYPOPITUITARISM.	""	0	#FFFFFF
D025981	C26.531	Hip Injuries	General or unspecified injuries involving the hip.	""	0	#FFFFFF
D026681	C18.654.521.500.133.699.901	Vitamin B 6 Deficiency	A nutritional condition produced by a deficiency of VITAMIN B 6 in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures. Deficiency can be caused by certain medications, such as isoniazid.	""	0	#FFFFFF
D027601	C01.925.256.721	Polyomavirus Infections	Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).	""	0	#FFFFFF
D028226	C16.320.565.176|C18.452.648.176|C18.452.845.500.075	Amyloidosis, Familial	Diseases in which there is a familial pattern of AMYLOIDOSIS.	""	0	#FFFFFF
D028227	C10.574.500.050|C10.668.829.050.050|C16.320.400.050|C16.320.565.176.050|C18.452.648.176.050|C18.452.845.500.050.050|C18.452.845.500.075.050	Amyloid Neuropathies, Familial	Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN.	""	0	#FFFFFF
D028243	C10.228.140.163.100.168|C10.228.140.300.275.311|C10.228.140.300.510.200.200.160|C14.907.253.329.311|C14.907.253.560.200.200.160|C16.320.565.176.160|C16.320.565.189.168|C18.452.132.100.168|C18.452.648.176.160|C18.452.648.189.168|C18.452.845.500.075.160|C18.452.845.500.100.160	Cerebral Amyloid Angiopathy, Familial	A familial disorder marked by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES.	""	0	#FFFFFF
D028361	C18.452.660	Mitochondrial Diseases	Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.	""	0	#FFFFFF
D028921	C16.320.565.100.620.100|C16.320.565.202.720.100|C18.452.648.100.620.100|C18.452.648.202.720.100	Biotinidase Deficiency	The late onset form of MULTIPLE CARBOXYLASE DEFICIENCY (deficiency of the activities of biotin-dependent enzymes propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, and PYRUVATE CARBOXYLASE) due to a defect or deficiency in biotinidase which is essential for recycling BIOTIN.	""	0	#FFFFFF
D028922	C16.320.565.100.620.380|C16.320.565.202.720.380|C18.452.648.100.620.380|C18.452.648.202.720.380	Holocarboxylase Synthetase Deficiency	The neonatal form of MULTIPLE CARBOXYLASE DEFICIENCY that is caused by a defect or deficiency in holocarboxylase synthetase. HLCS is the enzyme that covalently links biotin to the biotin dependent carboxylases (propionyl-CoA-carboxylase, pyruvate carboxylase, and beta-methylcrotonyl-CoA carboxylase).	""	0	#FFFFFF
D029021	C01.925.782.580.600.500.600|C22.706	Peste-des-Petits-Ruminants	A highly fatal contagious disease of goats and sheep caused by PESTE-DES-PETITS-RUMINANTS VIRUS. The disease may be acute or subacute and is characterized by stomatitis, conjunctivitis, diarrhea, and pneumonia.	""	0	#FFFFFF
D029241	C10.292.700.225.500.100|C10.574.500.662.100|C11.270.564.100|C11.640.451.451.100|C16.320.290.564.100|C16.320.400.630.100|C18.452.660.665	Optic Atrophy, Autosomal Dominant	Dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (Hum. Genet. 1998; 102: 79-86). Mutations leading to this condition have been mapped to the OPA1 gene at chromosome 3q28-q29. OPA1 codes for a dynamin-related GTPase that localizes to mitochondria.	""	0	#FFFFFF
D029242	C10.292.700.225.500.400|C10.574.500.662.400|C11.270.564.400|C11.640.451.451.400|C16.320.290.564.400|C16.320.400.630.400|C18.452.660.670	Optic Atrophy, Hereditary, Leber	A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))	""	0	#FFFFFF
D029424	C08.381.495.389|C23.550.291.500.875	Pulmonary Disease, Chronic Obstructive	A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.	""	0	#FFFFFF
D029461	C10.228.140.163.100.435.810|C16.320.565.189.435.810|C16.320.565.595.554.810|C18.452.132.100.435.810|C18.452.648.189.435.810|C18.452.648.595.554.810	Sialic Acid Storage Disease	Autosomal recessive neurodegenerative disorders caused by lysosomal membrane transport defects that result in accumulation of free sialic acid (N-ACETYLNEURAMINIC ACID) within the lysosomes. The two main clinical phenotypes, which are allelic variants of the SLC17A5 gene, are ISSD, a severe infantile form, or Salla disease, a slowly progressive adult form, named for the geographic area in Finland where the kindred first studied resided.	""	0	#FFFFFF
D029481	C01.748.099.567|C08.127.446.567|C08.381.495.146.567|C08.381.495.389.500|C08.730.099.567|C23.550.291.500.875.750	Bronchitis, Chronic	A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.	""	0	#FFFFFF
D029502	C15.378.071.085.080|C15.378.190.223.500.500|C16.320.077	Anemia, Hypoplastic, Congenital	An inborn condition characterized by deficiencies of red cell precursors that sometimes also includes LEUKOPENIA and THROMBOCYTOPENIA.	""	0	#FFFFFF
D029503	C15.378.071.085.080.090|C15.378.071.750.500|C15.378.190.223.500.500.090|C16.320.077.090	Anemia, Diamond-Blackfan	A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)	""	0	#FFFFFF
D029593	C14.280.067.565.440|C14.280.123.625.440|C16.131.240.400.715.440	Jervell-Lange Nielsen Syndrome	A form of long QT syndrome that is associated with congenital deafness. It is characterized by abnormal cardioelectrophysiology involving the VOLTAGE-GATED POTASSIUM CHANNEL. It results from mutation of KCNQ1 gene (Subtype 1 or JLN1) or the KCNE1 gene (Subtype 2 or JLN2).	""	0	#FFFFFF
D029597	C14.280.067.565.720|C14.280.123.625.720|C16.131.240.400.715.720|C23.550.073.547.720	Romano-Ward Syndrome	A form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the VOLTAGE-GATED POTASSIUM CHANNEL.	""	0	#FFFFFF
D030243	C01.925.782.350.675.400|C22.196.400	Hemorrhagic Syndrome, Bovine	Clinically severe acute disease of cattle caused by noncytopathic forms of Bovine viral diarrhea virus 2 (DIARRHEA VIRUS 2, BOVINE VIRAL). Outbreaks are characterized by high morbidity and high mortality.	""	0	#FFFFFF
D030321	C04.557.435.595.220|C04.588.945.947.535.585.220|C04.700.900.220|C12.050.351.875.253.096.562|C12.050.351.937.820.535.585.220|C12.050.351.968.419.473.585.220|C12.200.706.316.096.562|C12.200.758.820.750.585.220|C12.200.777.419.473.585.220|C12.800.316.096.562|C12.900.820.535.585.220|C12.950.419.473.585.220|C12.950.983.535.585.220|C16.131.939.316.096.562|C16.320.700.900.220|C19.391.119.096.562	Denys-Drash Syndrome	A disorder of sex development characterized by UROGENITAL ABNORMALITIES; GONADAL DYSGENESIS; and WILMS TUMOR. It is caused by a mutation in the Wilms tumor suppressor gene (GENES, WILMS TUMOR) on chromosome 11.	""	0	#FFFFFF
D030341	C01.925.782.600	Nidovirales Infections	Infections with viruses of the order NIDOVIRALES. The concept includes ARTERIVIRUS INFECTIONS and CORONAVIRIDAE INFECTIONS.	""	0	#FFFFFF
D030342	C16.320	Genetic Diseases, Inborn	Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.	""	0	#FFFFFF
D030361	C01.925.256.650|C01.925.928.725	Papillomavirus Infections	Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.	""	0	#FFFFFF
D030401	C16.320.565.240|C18.452.660.195	Cytochrome-c Oxidase Deficiency	A disease that results from a congenital defect in ELECTRON TRANSPORT COMPLEX IV. Defects in ELECTRON TRANSPORT COMPLEX IV can be caused by mutations in the SURF1, SCO2, COX10, or SCO1 genes. ELECTRON TRANSPORT COMPLEX IV deficiency caused by mutation in SURF1 manifests itself as LEIGH DISEASE; that caused by mutation in SCO2 as fatal infantile cardioencephalomyopathy; that caused by mutation in COX10 as tubulopathy and leukodystrophy; and that caused by mutation in SCO1 as early-onset hepatic failure and neurologic disorder. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#220110, May 17, 2001)	""	0	#FFFFFF
D030981	C05.116.099.052|C05.116.264.579.052	Acro-Osteolysis	A condition with congenital and acquired forms causing recurrent ulcers in the fingers and toes. The congenital form exhibits autosomal dominant inheritance; the acquired form is found in workers who handle VINYL CHLORIDE. When acro-osteolysis is accompanied by generalized OSTEOPOROSIS and skull deformations, it is called HAJDU-CHENEY SYNDROME.	""	0	#FFFFFF
D031221	C05.550.518.500|C26.289.500|C26.558.554.500	Knee Dislocation	Slippage of the FEMUR off the TIBIA.	""	0	#FFFFFF
D031222	C05.550.518.625|C26.289.625|C26.558.554.750	Patellar Dislocation	Displacement of the PATELLA from the femoral groove.	""	0	#FFFFFF
D031249	C15.604.250.410.224	Erdheim-Chester Disease	A rare form of non-Langerhans-cell histiocytosis (HISTIOCYTOSIS, NON-LANGERHANS-CELL) with onset in middle age. The systemic disease is characterized by infiltration of lipid-laden macrophages, multinucleated giant cells, an inflammatory infiltrate of lymphocytes and histiocytes in the bone marrow, and a generalized sclerosis of the long bones.	""	0	#FFFFFF
D031261	C01.655|C22.131.728.650	Poult Enteritis Mortality Syndrome	An acute, transmissible, infectious disease associated with high MORTALITY and MORBIDITY in young turkeys (poults). It is characterized by DIARRHEA; ANOREXIA; growth depression, and immune dysfunction. The cause is unknown but astroviruses (AVASTROVIRUS) and coronaviruses (CORONAVIRUS, TURKEY) have been isolated from diseased poults and are thought to cause the enteritis and increased susceptibility to bacterial infections.	""	0	#FFFFFF
D031300	C11.768.757|C14.907.940.815	Retinal Vasculitis	Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.	""	0	#FFFFFF
D031368	C01.925.256.466.930.750.970	Zoster Sine Herpete	HERPES ZOSTER but without eruption of vesicles. Patients exhibit the characteristic pain minus the skin rash, sometimes making diagnosis difficult.	""	0	#FFFFFF
D031845	C05.116.099.052.400|C05.116.264.579.052.400|C16.131.621.445|C16.320.355	Hajdu-Cheney Syndrome	Rare, autosomal dominant syndrome characterized by ACRO-OSTEOLYSIS, generalized OSTEOPOROSIS, and skull deformations.	""	0	#FFFFFF
D031901	C04.557.465.955.416|C04.850.908.416|C12.050.703.720.949.416	Gestational Trophoblastic Disease	A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.	""	0	#FFFFFF
D031941	C01.925.782.580.830.450|C22.362.450|C23.550.470.790.500.900.400	Hemorrhagic Septicemia, Viral	A systemic infection of various salmonid and a few nonsalmonid fishes caused by Viral hemorrhagic septicemia virus (see NOVIRHABDOVIRUS),	""	0	#FFFFFF
D031954	C04.557.465.955.207.438|C04.557.470.200.025.455.750|C04.850.908.208.438|C12.050.703.720.949.208.438	Choriocarcinoma, Non-gestational	A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.	""	0	#FFFFFF
D033461	C23.550.449	Hyperuricemia	Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.	""	0	#FFFFFF
D034062	C01.207.800.392|C10.228.228.800.392|C10.574.843.512|C10.886.425.800.800.400	Insomnia, Fatal Familial	An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).	""	0	#FFFFFF
D034081	C01.207.800.858|C10.228.228.800.858|C10.574.843.925|C22.955|C23.550.291.500.937	Wasting Disease, Chronic	A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS).	""	0	#FFFFFF
D034141	C15.378.147.607.500	Hypoalbuminemia	A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).	""	0	#FFFFFF
D034161	C01.635	Pelvic Infection	Infection involving the tissues or organs in the PELVIS.	""	0	#FFFFFF
D034321	C23.550.425	Hyperamylasemia	A condition with abnormally elevated level of AMYLASES in the serum. Hyperamylasemia due to PANCREATITIS or other causes may be differentiated by identifying the amylase isoenzymes.	""	0	#FFFFFF
D034381	C09.218.458.341|C10.597.751.418.341|C23.888.592.763.393.341	Hearing Loss	A general term for the complete or partial loss of the ability to hear from one or both ears.	""	0	#FFFFFF
D034701	C04.557.450.565.465.500|C04.588.805.309|C17.800.882.356|C20.762.750.563	Mastocytosis, Cutaneous	Skin lesions due to abnormal infiltration of MAST CELLS. Cutaneous mastocytosis is confined to the skin without the involvement of other tissues or organs, and is mostly found in children. The three major variants are: URTICARIA PIGMENTOSA; diffuse cutaneous mastocytosis; and SOLITARY MASTOCYTOMA OF SKIN.	""	0	#FFFFFF
D034721	C04.557.450.565.465.750|C20.762.750.750	Mastocytosis, Systemic	A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.	""	0	#FFFFFF
D034801	C04.557.450.565.465.249|C20.762.750.469	Mastocytoma	A solid tumor consisting of a dense infiltration of MAST CELLS. It is generally benign.	""	0	#FFFFFF
D035583	C23.550.291.906	Rare Diseases	A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.	""	0	#FFFFFF
D036821	C04.557.450.565.325|C04.557.450.795.332|C12.050.351.500.852.762.200.500|C12.050.351.937.418.875.200.374|C12.100.250.852.762.200.500|C12.900.418.875.200.374	Endometrial Stromal Tumors	Neoplasms of the endometrial stroma that sometimes involve the MYOMETRIUM. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (SARCOMA, ENDOMETRIAL STROMAL).	""	0	#FFFFFF
D036841	C25.723.415.246	Ciguatera Poisoning	Poisoning caused by ingestion of SEAFOOD containing microgram levels of CIGUATOXINS. The poisoning is characterized by gastrointestinal, neurological and cardiovascular disturbances.	""	0	#FFFFFF
D036981	C05.321.600|C05.360.350	Fasciitis, Plantar	Inflammation of the plantar fascia (APONEUROSIS) on the bottom of the foot causing heel pain. The etiology of plantar fasciitis remains controversial but is likely to involve a biomechanical imbalance. Though often presenting along with HEEL SPUR, they do not appear to be causally related.	""	0	#FFFFFF
D036982	C05.116.540.310.600|C05.360.400	Heel Spur	A bony outgrowth on the lower surface of the CALCANEUS. Though often presenting along with plantar fasciitis (FASCIITIS, PLANTAR), they are not considered causally related.	""	0	#FFFFFF
D037061	C05.360.500|C05.550.610|C23.888.592.612.540	Metatarsalgia	Pain in the region of the METATARSUS. It can include pain in the METATARSAL BONES; METATARSOPHALANGEAL JOINT; and/or intermetatarsal joints (TARSAL JOINTS).	""	0	#FFFFFF
D037081	C05.360.750	Posterior Tibial Tendon Dysfunction	A condition characterized by a broad range of progressive disorders ranging from TENOSYNOVITIS to tendon rupture with or without hindfoot collapse to a fixed, rigid, FLATFOOT deformity. Pathologic changes can involve associated tendons, ligaments, joint structures of the ANKLE, hindfoot, and midfoot. Posterior tibial tendon dysfunction is the most common cause of acquired flatfoot deformity in adults.	""	0	#FFFFFF
D037801	C05.330.615	Hammer Toe Syndrome	A condition characterized by a series of interrelated digital symptoms and joint changes of the lesser digits and METATARSOPHALANGEAL JOINTS of the FOOT. The syndrome can include some or all of the following conditions: hammer toe, claw toe, mallet toe, overlapping fifth toe, curly toe, EXOSTOSIS; HYPEROSTOSIS; interdigital heloma, or contracted toe.	""	0	#FFFFFF
D038061	C05.660.585.512|C16.131.621.585.512	Lower Extremity Deformities, Congenital	Congenital structural abnormalities of the LOWER EXTREMITY.	""	0	#FFFFFF
D038062	C05.660.585.988|C16.131.621.585.988	Upper Extremity Deformities, Congenital	Congenital structural abnormalities of the UPPER EXTREMITY.	""	0	#FFFFFF
D038223	C10.900.300.350.300.500|C26.915.300.450.500.500|C26.974.382.200.500	Post-Concussion Syndrome	The organic and psychogenic disturbances observed after closed head injuries (HEAD INJURIES, CLOSED). Post-concussion syndrome includes subjective physical complaints (i.e. headache, dizziness), cognitive, emotional, and behavioral changes. These disturbances can be chronic, permanent, or late emerging.	""	0	#FFFFFF
D038261	C10.228.140.163.100.362.312|C10.228.140.695.625.312|C10.314.400.312|C10.574.500.024|C16.320.400.024|C16.320.565.189.362.312|C18.452.132.100.362.312|C18.452.648.189.362.312	Alexander Disease	Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.	""	0	#FFFFFF
D038642	C10.900.300.087.850|C26.915.300.200.825	Shaken Baby Syndrome	Brain injuries resulted from vigorous shaking of an infant or young child held by the chest, shoulders, or extremities causing extreme cranial acceleration. It is characterized by the intracranial and intraocular hemorrhages with no evident external trauma. Serious cases may result in death.	""	0	#FFFFFF
D038901	C10.597.606.360.455|C16.320.322.500|C16.320.400.525	Mental Retardation, X-Linked	A class of genetic disorders resulting in INTELLECTUAL DISABILITY that is associated either with mutations of GENES located on the X CHROMOSOME or aberrations in the structure of the X chromosome (SEX CHROMOSOME ABERRATIONS).	""	0	#FFFFFF
D038921	C10.597.606.360.455.249|C16.320.322.500.249|C16.320.400.525.249	Coffin-Lowry Syndrome	A rare, X-linked INTELLECTUAL DISABILITY syndrome that results from mutations in the RIBOSOMAL PROTEIN S6 KINASE gene. Typical manifestations of the disease include an intelligence quotient of less than 50, facial anomalies, and other malformations.	""	0	#FFFFFF
D039141	C05.651.534.500.450|C10.668.491.175.500.450|C16.320.577.450	Muscular Dystrophy, Oculopharyngeal	An autosomal dominant hereditary disease that presents in late in life and is characterized by DYSPHAGIA and progressive ptosis of the eyelids. Mutations in the gene for POLY(A)-BINDING PROTEIN II have been associated with oculopharyngeal muscular dystrophy.	""	0	#FFFFFF
D039682	C01.221.250.875.550|C01.221.812.640.400.530|C01.778.640.400.530|C01.925.782.815.616.400.550|C01.925.813.400.530|C12.100.937.640.400.530|C17.800.849.391.400|C18.452.584.625.400|C18.452.880.391.400|C20.673.480.400	HIV-Associated Lipodystrophy Syndrome	Defective metabolism leading to fat maldistribution in patients infected with HIV. The etiology appears to be multifactorial and probably involves some combination of infection-induced alterations in metabolism, direct effects of antiretroviral therapy, and patient-related factors.	""	0	#FFFFFF
D039941	C01.150.252.410.110	Bifidobacteriales Infections	Infections with BACTERIA of the order Bifidobacteriales. This includes infections in the genera BIFIDOBACTERIUM and GARDNERELLA, in the family Bifidobacteriaceae.	""	0	#FFFFFF
D040181	C16.320.322	Genetic Diseases, X-Linked	Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. Included here are animal models of human X-linked diseases.	""	0	#FFFFFF
D041441	C11.768.585.865	Retinoschisis	A vitreoretinal dystrophy characterized by splitting of the neuroretinal layers. It occurs in two forms: degenerative retinoschisis and X chromosome-linked juvenile retinoschisis.	""	0	#FFFFFF
D041761	C06.130.409.178|C06.130.564.332	Cholecystolithiasis	Presence or formation of GALLSTONES in the GALLBLADDER.	""	0	#FFFFFF
D041781	C23.550.429.500.755|C23.888.885.375.500	Jaundice, Obstructive	Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.	""	0	#FFFFFF
D041881	C06.130.564.263.500	Cholecystitis, Acute	Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.	""	0	#FFFFFF
D041882	C06.130.564.263.500.500	Emphysematous Cholecystitis	A variant of acute cholecystitis with inflammation of the GALLBLADDER that is characterized by the pockets of gas in the gallbladder wall. It is due to secondary infection caused by gas-forming organisms, and has a high risk of perforation.	""	0	#FFFFFF
D042101	C06.130.564.263.249	Acalculous Cholecystitis	Inflammation of the GALLBLADDER wall in the absence of GALLSTONES.	""	0	#FFFFFF
D042822	C23.550.362	Genomic Instability	An increased tendency of the GENOME to acquire MUTATIONS when various processes involved in maintaining and replicating the genome are dysfunctional.	""	0	#FFFFFF
D042882	C06.130.409.633|C06.130.564.332.500|C23.300.175.525	Gallstones	Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.	""	0	#FFFFFF
D042883	C06.130.120.250.174|C06.130.409.267	Choledocholithiasis	Presence or formation of GALLSTONES in the COMMON BILE DUCT.	""	0	#FFFFFF
D043171	C23.550.210.110|C23.550.362.180	Chromosomal Instability	An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.	""	0	#FFFFFF
D043183	C06.405.469.158.272.608	Irritable Bowel Syndrome	A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.	""	0	#FFFFFF
D043202	C16.320.565.925|C18.452.648.925	Steroid Metabolism, Inborn Errors	Errors in metabolic processing of STEROIDS resulting from inborn genetic mutations that are inherited or acquired in utero.	""	0	#FFFFFF
D043204	C16.320.565.925.500|C18.452.648.925.500	Mineralocorticoid Excess Syndrome, Apparent	A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS.	""	0	#FFFFFF
D043604	C04.557.465.625.650.700.705.360|C04.557.580.625.650.700.705.360	Glomus Tympanicum Tumor	A rare PARAGANGLIOMA involving the GLOMUS TYMPANICUM, a collection of chemoreceptor tissue adjacent to the TYMPANIC CAVITY. It can cause TINNITUS and conductive hearing loss (HEARING LOSS, CONDUCTIVE).	""	0	#FFFFFF
D043963	C06.405.469.158.587	Diverticulosis, Colonic	A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.	""	0	#FFFFFF
D044148	C15.604.451|C16.131.482	Lymphatic Abnormalities	Congenital or acquired structural abnormalities of the lymphatic system (LYMPHOID TISSUE) including the lymph vessels.	""	0	#FFFFFF
D044225	C01.150.252.400.719	Piscirickettsiaceae Infections	Infections with bacteria of the family PISCIRICKETTSIACEAE, causing septicemic disease of salmonid fish (SALMONIDAE). Piscirickettsia-like bacteria are also associated with disease syndromes in non-salmonid fish.	""	0	#FFFFFF
D044342	C18.654.521	Malnutrition	An imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiological requirement.	""	0	#FFFFFF
D044343	C18.654.726	Overnutrition	An imbalanced NUTRITIONAL STATUS resulting from excessive intake of nutrients. Generally, overnutrition generates an energy imbalance between food consumption and energy expenditure leading to disorders such as OBESITY.	""	0	#FFFFFF
D044483	C06.405.469.578	Intestinal Polyposis	The growth of INTESTINAL POLYPS. Growth processes include neoplastic (ADENOMA and CARCINOMA) and non-neoplastic (hyperplastic, mucosal, inflammatory, and other polyps).	""	0	#FFFFFF
D044504	C06.405.205.596.750|C06.405.469.363.750	Enterocolitis, Neutropenic	A syndrome characterized by inflammation in the ILEUM, the CECUM, and the ASCENDING COLON. It is observed in cancer patients with CHEMOTHERAPY-induced NEUTROPENIA or in other immunocompromised individuals (IMMUNOCOMPROMISED HOST).	""	0	#FFFFFF
D044542	C05.660.207.525|C14.240.400.695|C14.280.400.695|C14.280.484.716.525|C16.131.077.525|C16.131.240.400.685|C16.131.621.207.525|C17.800.621.430.530.550.525	LEOPARD Syndrome	An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.	""	0	#FFFFFF
D044584	C04.557.470.200.025.232|C04.557.470.615.132	Carcinoma, Ductal	Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.	""	0	#FFFFFF
D044882	C18.452.394	Glucose Metabolism Disorders	Pathological conditions in which the BLOOD GLUCOSE cannot be maintained within the normal range, such as in HYPOGLYCEMIA and HYPERGLYCEMIA. Etiology of these disorders varies. Plasma glucose concentration is critical to survival for it is the predominant fuel for the CENTRAL NERVOUS SYSTEM.	""	0	#FFFFFF
D044903	C06.689.150|C16.614.200|C18.452.394.968.250|C18.452.394.984.200	Congenital Hyperinsulinism	A familial, nontransient HYPOGLYCEMIA with defects in negative feedback of GLUCOSE-regulated INSULIN release. Clinical phenotypes include HYPOGLYCEMIA; HYPERINSULINEMIA; SEIZURES; COMA; and often large BIRTH WEIGHT. Several sub-types exist with the most common, type 1, associated with mutations on an ATP-BINDING CASSETTE TRANSPORTERS (subfamily C, member 8).	""	0	#FFFFFF
D044904	C16.320.565.202.607|C16.320.565.595.577|C18.452.648.202.607|C18.452.648.595.577	Mannosidase Deficiency Diseases	Diseases caused by the loss of one or more enzymes involved in the hydrolysis of mannoside linkages (MANNOSIDASES). The defects in enzyme activity are primarily associated with genetic mutation of the genes that codes for a particular mannosidase isoenzyme.	""	0	#FFFFFF
D044905	C16.320.565.202.607.750|C16.320.565.595.577.750|C18.452.648.202.607.750|C18.452.648.595.577.750	beta-Mannosidosis	An inborn error of metabolism marked by a defect in the lysosomal isoform of BETA-MANNOSIDASE that results in lysosomal accumulation of mannose-rich intermediate metabolites containing 1,4-beta linkages. The human disease occurs through autosomal recessive inheritance and manifests in the form of a variety of symptoms that depend upon the type of gene mutation.	""	0	#FFFFFF
D045169	C01.748.730|C01.925.782.600.550.200.750|C08.730.730	Severe Acute Respiratory Syndrome	A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.	""	0	#FFFFFF
D045262	C23.888.760	Reticulocytosis	An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.	""	0	#FFFFFF
D045463	C01.925.782.580.600.080	Avulavirus Infections	Infections with viruses of the genus AVULAVIRUS, family PARAMYXOVIRIDAE. This includes NEWCASTLE DISEASE and other infections of domestic fowl.	""	0	#FFFFFF
D045464	C01.925.782.580.600.400	Henipavirus Infections	Infections with viruses of the genus HENIPAVIRUS, family PARAMYXOVIRIDAE.	""	0	#FFFFFF
D045602	C06.405.469.637.887|C18.452.603.887	Steatorrhea	A condition that is characterized by chronic fatty DIARRHEA, a result of abnormal DIGESTION and/or INTESTINAL ABSORPTION of FATS.	""	0	#FFFFFF
D045723	C06.405.117.136|C06.405.205.282.500.438	Diverticulosis, Esophageal	A pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS.	""	0	#FFFFFF
D045724	C06.405.205.282.500.625|C06.405.748.142	Diverticulosis, Stomach	A pathological condition characterized by the presence of a number of GASTRIC DIVERTICULA in the STOMACH.	""	0	#FFFFFF
D045729	C01.150.252.620.330|C01.748.610.540.540|C08.381.677.540.400|C08.730.610.540.540|C22.905.626	Pneumonia of Swine, Mycoplasmal	A chronic, clinically mild, infectious pneumonia of PIGS caused by MYCOPLASMA HYOPNEUMONIAE. Ninety percent of swine herds worldwide are infected with this economically costly disease that primarily affects animals aged two to six months old. The disease can be associated with porcine respiratory disease complex. PASTEURELLA MULTOCIDA is often found as a secondary infection.	""	0	#FFFFFF
D045743	C17.300.799.602|C17.800.784.602	Scleroderma, Diffuse	A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.	""	0	#FFFFFF
D045745	C17.300.799.801|C17.800.784.801	Scleroderma, Limited	The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.	""	0	#FFFFFF
D045822	C06.405.469.531.568|C23.300.970.500	Intestinal Volvulus	A twisting in the intestine (INTESTINES) that can cause INTESTINAL OBSTRUCTION.	""	0	#FFFFFF
D045823	C06.405.469.531.492	Ileus	A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.	""	0	#FFFFFF
D045824	C01.150.252.400.260	Desulfovibrionaceae Infections	Infections with bacteria of the family Desulfovibrionaceae.	""	0	#FFFFFF
D045825	C01.150.252.400.388	Fusobacteriaceae Infections	Infections with bacteria of the family Fusobacteriaceae, in the order Fusobacterales, phylum FUSOBACTERIA.	""	0	#FFFFFF
D045826	C01.150.252.400.349	Flavobacteriaceae Infections	Infections with bacteria of the family FLAVOBACTERIACEAE.	""	0	#FFFFFF
D045827	C01.150.252.400.245	Cytophagaceae Infections	Infections with bacteria of the family CYTOPHAGACEAE.	""	0	#FFFFFF
D045828	C01.150.252.400.560	Moraxellaceae Infections	Infections with bacteria of the family MORAXELLACEAE.	""	0	#FFFFFF
D045888	C04.182.347|C17.300.550.274	Ganglion Cysts	Nodular tumor-like lesions or mucoid flesh, arising from tendon sheaths, LIGAMENTS, or JOINT CAPSULE, especially of the hands, wrists, or feet. They are not true cysts as they lack epithelial wall. They are distinguished from SYNOVIAL CYSTS by the lack of communication with a joint cavity or the SYNOVIAL MEMBRANE.	""	0	#FFFFFF
D045908	C01.925.256.743.615|C22.735.750|C22.795.600	Monkeypox	A viral disease infecting PRIMATES and RODENTS. Its clinical presentation in humans is similar to SMALLPOX including FEVER; HEADACHE; COUGH; and a painful RASH. It is caused by MONKEYPOX VIRUS and is usually transmitted to humans through BITES or via contact with an animal's BLOOD. Interhuman transmission is relatively low (significantly less than smallpox).	""	0	#FFFFFF
D046088	C09.218.458.341.950|C10.597.751.418.341.950|C23.888.592.763.393.341.950	Hearing Loss, Unilateral	Partial or complete hearing loss in one ear.	""	0	#FFFFFF
D046089	C09.218.458.341.849|C10.597.751.418.341.849|C23.888.592.763.393.341.849	Hearing Loss, Mixed Conductive-Sensorineural	Hearing loss due to damage or impairment of both the conductive elements (HEARING LOSS, CONDUCTIVE) and the sensorineural elements (HEARING LOSS, SENSORINEURAL) of the ear.	""	0	#FFFFFF
D046110	C12.050.703.395|C14.907.489.480	Hypertension, Pregnancy-Induced	A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.	""	0	#FFFFFF
D046150	C05.116.099.343.679|C16.320.240.750|C19.297.656	Laron Syndrome	An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.	""	0	#FFFFFF
D046151	C16.131.894.500|C19.874.689.500	Lingual Thyroid	A condition characterized by the presence of rudimentary THYROID tissue at the base of the TONGUE. It is due to failed embryonic development and migration of thyroid tissue to its normal location. The lingual thyroid usually cannot maintain adequate hormone production thereby resulting in HYPOTHYROIDISM.	""	0	#FFFFFF
D046152	C04.557.450.565.370|C06.301.371.308|C06.405.249.308	Gastrointestinal Stromal Tumors	All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).	""	0	#FFFFFF
D046248	C06.405.748.340.690.500	Pyloric Stenosis, Hypertrophic	Narrowing of the pyloric canal due to HYPERTROPHY of the surrounding circular muscle. It is usually seen in infants or young children.	""	0	#FFFFFF
D046290	C01.830.025.020.455.730|C06.552.597.758	Liver Abscess, Pyogenic	Single or multiple areas of PUS due to bacterial infection within the hepatic parenchyma. It can be caused by a variety of BACTERIA, local or disseminated from infections elsewhere such as in APPENDICITIS; CHOLECYSTITIS; PERITONITIS; and after LIVER TRANSPLANTATION.	""	0	#FFFFFF
D046349	C06.552.830.074|C16.320.850.742.074|C17.800.827.742.074|C18.452.811.400.074	Coproporphyria, Hereditary	An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.	""	0	#FFFFFF
D046350	C06.552.830.625|C16.320.850.742.625|C17.800.827.742.625|C18.452.811.400.625	Porphyria, Variegate	An autosomal dominant porphyria that is due to a deficiency of protoporphyrinogen oxidase (EC 1.3.3.4) in the LIVER, the seventh enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, COPROPORPHYRINS and protoporphyrinogen.	""	0	#FFFFFF
D046351	C06.552.830.812|C16.320.850.742.812|C17.800.827.742.812|C18.452.811.400.812	Protoporphyria, Erythropoietic	An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces.	""	0	#FFFFFF
D046449	C23.300.707.374	Hernia, Abdominal	A protrusion of abdominal structures through the retaining ABDOMINAL WALL. It involves two parts: an opening in the abdominal wall, and a hernia sac consisting of PERITONEUM and abdominal contents. Abdominal hernias include groin hernia (HERNIA, FEMORAL; HERNIA, INGUINAL) and VENTRAL HERNIA.	""	0	#FFFFFF
D046548	C05.550.518.192.500|C12.050.703.844.728|C26.289.192.500	Pubic Symphysis Diastasis	Separation of the PUBIC SYMPHYSIS. It is an uncommon complication of CHILDBIRTH causing postpartum PAIN, but it can also arise from other causes.	""	0	#FFFFFF
D046589	C10.228.140.300.150.477.200.100|C10.228.140.300.275.249|C10.228.140.300.400.203|C10.228.140.300.510.200.175|C10.228.140.300.775.200.200.100|C10.228.140.380.230.124|C14.907.253.092.477.200.100|C14.907.253.329.249|C14.907.253.560.200.175|C14.907.253.855.200.200.100|C16.320.129|C23.550.513.355.250.200.100|C23.550.717.489.250.200.100	CADASIL	A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)	""	0	#FFFFFF
D046608	C10.597.350.675|C23.888.592.350.675	Synkinesis	An involuntary movement accompanying a volitional movement. It often refers to facial movements that accompany FACIAL PARALYSIS.	""	0	#FFFFFF
D046628	C06.130.120.250.098.800	Sphincter of Oddi Dysfunction	Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter.	""	0	#FFFFFF
D046648	C10.228.140.300.535.450.400.400|C10.900.300.837.600.400|C14.907.253.573.400.450.400|C23.550.414.838.700.400|C23.550.414.913.700.400|C26.915.300.490.450.400	Hematoma, Subdural, Intracranial	Accumulation of blood in the SUBDURAL SPACE over the CEREBRAL HEMISPHERE.	""	0	#FFFFFF
D046649	C23.550.414.838.700.700	Hematoma, Subdural, Spinal	Subdural hematoma of the SPINAL CANAL.	""	0	#FFFFFF
D046728	C06.405.205.265.173|C06.405.469.158.188.173	Colitis, Microscopic	A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology.	""	0	#FFFFFF
D046729	C06.405.205.265.173.500|C06.405.469.158.188.173.500	Colitis, Collagenous	A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show larger-than-normal band of subepithelial COLLAGEN.	""	0	#FFFFFF
D046730	C06.405.205.265.173.750|C06.405.469.158.188.173.750	Colitis, Lymphocytic	A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).	""	0	#FFFFFF
D046748	C23.550.414.838.355	Hematoma, Epidural, Spinal	A rare epidural hematoma in the spinal epidural space, usually due to a vascular malformation (CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS) or TRAUMA. Spontaneous spinal epidural hematoma is a neurologic emergency due to a rapidly evolving compressive MYELOPATHY.	""	0	#FFFFFF
D046768	C06.689.150.500|C16.614.200.500|C18.452.394.968.250.500|C18.452.394.984.200.500	Nesidioblastosis	An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.	""	0	#FFFFFF
D046788	C05.550.700	Patellofemoral Pain Syndrome	A syndrome characterized by retropatellar or peripatellar PAIN resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) CHONDROMALACIA PATELLAE, the latter describing a pathological condition of the CARTILAGE and not a syndrome.	""	0	#FFFFFF
D046789	C05.182.100|C17.300.182.100	Chondromalacia Patellae	A degeneration of the ARTICULAR CARTILAGE of the PATELLA, caused by a decrease in sulfated MUCOPOLYSACCHARIDES in the ground substance. When accompanied by pain, it is sometimes considered part of or confused with PATELLOFEMORAL PAIN SYNDROME.	""	0	#FFFFFF
D047268	C16.131.894.500.500|C19.874.283.802|C19.874.689.500.500	Lingual Goiter	Pathological enlargement of the LINGUAL THYROID, ectopic thyroid tissue at the base of the TONGUE. It may cause upper AIRWAY OBSTRUCTION; DYSPHAGIA; or HYPOTHYROIDISM symptoms.	""	0	#FFFFFF
D047489	C21.676	Preconception Injuries	Damages to reproductive health prior to conception (FERTILIZATION), a legal term for torts liability concerning environmental safety issues. Preconception injuries may involve either the male or the female, such as chromosomal mutations in the OVA or the SPERMATOZOA.	""	0	#FFFFFF
D047508	C06.552.100.600|C06.552.308.500.750.500	Massive Hepatic Necrosis	"Extensive and rapid death of parenchymal cells in the LIVER, often due to exposure to toxic materials or drug-induced injury. It is characterized by a soft, flabby, yellow-brown wrinkled, and shrunken liver. It was called ""acute yellow atrophy""."	""	0	#FFFFFF
D047688	C04.182.156|C17.800.090.249	Breast Cyst	A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.	""	0	#FFFFFF
D047708	C04.557.450.565.540|C17.300.680.540	Myofibroma	A benign tumor that consists chiefly of fibrous CONNECTIVE TISSUE, with variable numbers of MUSCLE CELLS forming portions of the neoplasm (From Stedman's, 27th ed).	""	0	#FFFFFF
D047728	C11.744.636.500	Myopia, Degenerative	Excessive axial myopia associated with complications (especially posterior staphyloma and CHOROIDAL NEOVASCULARIZATION) that can lead to BLINDNESS.	""	0	#FFFFFF
D047748	C10.228.140.617.738.250.725|C19.700.355.800	Pituitary ACTH Hypersecretion	A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.	""	0	#FFFFFF
D047808	C12.050.351.875.253.090|C12.200.706.316.090|C12.800.316.090|C16.131.939.316.129|C19.391.119.090	Adrenogenital Syndrome	Abnormal SEX DIFFERENTIATION or congenital DISORDERS OF SEX DEVELOPMENT caused by abnormal levels of steroid hormones expressed by the GONADS or the ADRENAL GLANDS, such as in CONGENITAL ADRENAL HYPERPLASIA and ADRENAL CORTEX NEOPLASMS. Due to abnormal steroid biosynthesis, clinical features include VIRILISM in females; FEMINIZATION in males; or precocious sexual development in children.	""	0	#FFFFFF
D047868	C04.588.894.797.520.933|C08.381.540.867|C08.785.520.867	Pulmonary Sclerosing Hemangioma	A benign neoplasm of pneumocytes, cells of the PULMONARY ALVEOLI. Originally considered to be vascular in origin, it is now classified as an epithelial tumor with several elements, including solid cellular areas, papillary structure, sclerotic regions, and dilated blood-filled spaces resembling HEMANGIOMA.	""	0	#FFFFFF
D047928	C12.050.703.420.491.500	Premature Birth	CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).	""	0	#FFFFFF
D048070	C12.050.703.277.677|C18.654.521.625	Fetal Nutrition Disorders	Disorders caused by nutritional imbalance, either overnutrition or undernutrition, in the FETUS in utero.	""	0	#FFFFFF
D048089	C01.150.252.620.300|C01.748.085.630|C01.748.610.540.530|C08.381.677.540.300|C08.730.085.630|C08.730.610.540.530|C22.196.090.675	Pneumonia of Calves, Enzootic	Chronic endemic respiratory disease of dairy calves and an important component of bovine respiratory disease complex. It primarily affects calves up to six months of age and the etiology is multifactorial. Stress plus a primary viral infection is followed by a secondary bacterial infection. The latter is most commonly associated with PASTEURELLA MULTOCIDA producing a purulent BRONCHOPNEUMONIA. Sometimes present are MANNHEIMIA HAEMOLYTICA; HAEMOPHILUS SOMNUS and mycoplasma species.	""	0	#FFFFFF
D048090	C01.748.085|C08.730.085|C22.196.090	Bovine Respiratory Disease Complex	A multifactorial disease of CATTLE resulting from complex interactions between environmental factors, host factors, and pathogens. The environmental factors act as stressors adversely affecting the IMMUNE SYSTEM and other host defenses and enhancing transmission of infecting agents.	""	0	#FFFFFF
D048550	C06.552.308	Hepatic Insufficiency	Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.	""	0	#FFFFFF
D048629	C23.550.210.570	Micronuclei, Chromosome-Defective	Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.	""	0	#FFFFFF
D048909	C19.246.099	Diabetes Complications	Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.	""	0	#FFFFFF
D048949	C23.888.592.612.451	Labor Pain	Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.	""	0	#FFFFFF
D048968	C12.050.703.407|C23.888.821.937.049	Morning Sickness	Symptoms of NAUSEA and VOMITING in pregnant women that usually occur in the morning during the first 2 to 3 months of PREGNANCY. Severe persistent vomiting during pregnancy is called HYPEREMESIS GRAVIDARUM.	""	0	#FFFFFF
D049068	C05.660.207.707.624|C16.131.621.207.707.624	Plagiocephaly, Nonsynostotic	A deformity of the SKULL that is not due to bone fusion (SYNOSTOSIS), such as craniosynostoses, and is characterized by an asymmetric skull and face. It is observed with an increased frequency in INFANTS after the adoption of supine sleeping recommendations to prevent SUDDEN INFANT DEATH SYNDROME.	""	0	#FFFFFF
D049188	C12.050.703.824	Prenatal Injuries	Damages to the EMBRYO, MAMMALIAN or the FETUS before BIRTH. Damages can be caused by any factors including biological, chemical, or physical.	""	0	#FFFFFF
D049248	C26.986.224	Decapitation	Traumatic or experimentally induced separation of the head from the body in an animal or human.	""	0	#FFFFFF
D049288	C05.651.534.500.280|C10.668.491.175.500.149|C16.320.577.280	Muscular Dystrophies, Limb-Girdle	A heterogenous group of inherited muscular dystrophy that can be autosomal dominant or autosomal recessive. There are many forms (called LGMDs) involving genes encoding muscle membrane proteins such as the sarcoglycan (SARCOGLYCANS) complex that interacts with DYSTROPHIN. The disease is characterized by progressing wasting and weakness of the proximal muscles of arms and legs around the HIPS and SHOULDERS (the pelvic and shoulder girdles).	""	0	#FFFFFF
D049290	C10.228.140.163.100.435.825.300.300.750|C16.320.565.189.435.825.300.300.750|C16.320.565.398.641.803.350.300.925|C16.320.565.595.554.825.300.300.920|C18.452.132.100.435.825.300.300.750|C18.452.584.563.641.803.350.300.925|C18.452.648.189.435.825.300.300.750|C18.452.648.398.641.803.350.300.925|C18.452.648.595.554.825.300.300.920	Tay-Sachs Disease, AB Variant	A progressive neurodegenerative disorder that begins with muscle weakness, then progresses to startle reaction, retardation and seizures. It is characterized by the accumulation of G(M2) GANGLIOSIDE in neurons that is caused by a lack of G(M2) ACTIVATOR PROTEIN function. The AB variant designation refers to the increase of both HEXOSAMINIDASE A and HEXOSAMINIDASE B in tissues that lack of G(M2) activator protein.	""	0	#FFFFFF
D049291	C23.550.470.640	Seroma	Tumor-like sterile accumulation of serum in a tissue, organ, or cavity. It results from a tissue insult and is the product of tissue inflammation. It most commonly occurs following MASTECTOMY.	""	0	#FFFFFF
D049292	C23.550.522	Leukoaraiosis	Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS.	""	0	#FFFFFF
D049309	C04.557.470.700.040|C04.588.805.040	Acanthoma	A neoplasm composed of squamous or epidermal cells.	""	0	#FFFFFF
D049310	C05.651.534.500.074|C10.668.491.175.500.074|C16.320.577.074	Distal Myopathies	A heterogeneous group of genetic disorders characterized by progressive MUSCULAR ATROPHY and MUSCLE WEAKNESS beginning in the hands, the legs, or the feet. Most are adult-onset autosomal dominant forms. Others are autosomal recessive.	""	0	#FFFFFF
D049328	C04.557.665.560.615.530	Mongolian Spot	A bluish-gray to gray-brown benign, melanocytic nevus found usually in the LUMBOSACRAL REGION of dark-skinned people, especially those of East Asian ancestry. It is usually congenital or appears shortly after birth, and disappears in childhood.	""	0	#FFFFFF
D049912	C04.557.470.035.415|C04.588.322.609.292|C10.228.140.617.738.675.299|C19.344.609.292|C19.700.734.292	Growth Hormone-Secreting Pituitary Adenoma	A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.	""	0	#FFFFFF
D049913	C04.557.470.035.012|C04.588.322.609.145|C10.228.140.617.738.675.149|C19.344.609.145|C19.700.734.145	ACTH-Secreting Pituitary Adenoma	A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.	""	0	#FFFFFF
D049914	C18.452.284	DNA Repair-Deficiency Disorders	Disorders resulting from defective DNA REPAIR processes or the associated cellular responses to DNA DAMAGE.	""	0	#FFFFFF
D049932	C18.452.284.600	Nijmegen Breakage Syndrome	A chromosome instability syndrome resulting from a defective response to DNA double-strand breaks. In addition to characteristic FACIES and MICROCEPHALY, patients have a range of findings including RADIOSENSITIVITY, immunodeficiency, increased cancer risk, and growth retardation. Causative mutations occur in the NBS1 gene, located on human chromosome 8q21. NBS1 codes for nibrin, the key regulator protein of the R/M/N (RAD50/MRE11/NBS1) protein complex which senses and mediates cellular response to DNA DAMAGE caused by IONIZING RADIATION.	""	0	#FFFFFF
D049950	C19.642.355.239	Hyperparathyroidism, Primary	A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.	""	0	#FFFFFF
D049970	C11.270.240|C11.675.349.500.500|C16.320.290.410|C19.874.283.605.500|C19.874.397.370.500|C20.111.555.500	Graves Ophthalmopathy	An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy.	""	0	#FFFFFF
D050010	C16.320.427|C19.874.410.249	Hyperthyroxinemia, Familial Dysalbuminemic	An inherited autosomal dominant trait characterized by abnormally elevated levels of total serum THYROXINE; (T4) in euthyroid patients with abnormal SERUM ALBUMIN that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and TSH are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the ALB gene on CHROMOSOME 4.	""	0	#FFFFFF
D050030	C14.280.067.565.070|C14.280.123.625.070|C16.131.240.400.715.070|C23.550.073.547.070	Andersen Syndrome	A form of inherited long QT syndrome (or LQT7) that is characterized by a triad of potassium-sensitive periodic paralysis, VENTRICULAR ECTOPIC BEATS, and abnormal features such as short stature, low-set ears, and SCOLIOSIS. It results from mutations of KCNJ2 gene which encodes a channel protein (INWARD RECTIFIER POTASSIUM CHANNELS) that regulates resting membrane potential.	""	0	#FFFFFF
D050031	C19.874.871.102.500	Hashimoto Disease	Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.	""	0	#FFFFFF
D050032	C12.050.703.844.714|C19.874.871.102.750	Postpartum Thyroiditis	Transient autoimmune thyroiditis occurring in the POSTPARTUM PERIOD. It is characterized by the presence of high titers of AUTOANTIBODIES against THYROID PEROXIDASE and THYROGLOBULIN. Clinical signs include the triphasic thyroid hormone pattern: beginning with THYROTOXICOSIS, followed with HYPOTHYROIDISM, then return to euthyroid state by 1 year postpartum.	""	0	#FFFFFF
D050033	C16.131.894|C19.874.689	Thyroid Dysgenesis	Defective development of the THYROID GLAND. This concept includes thyroid agenesis (aplasia), hypoplasia, or an ectopic gland. Clinical signs usually are those of CONGENITAL HYPOTHYROIDISM.	""	0	#FFFFFF
D050035	C12.050.351.875.253.309.631|C12.200.706.316.309.631|C12.800.316.309.631|C16.131.939.316.309.631|C19.391.119.309.631|C19.391.482.814	Sexual Infantilism	The permanent lack of SEXUAL DEVELOPMENT in an individual. This defect is usually observed at an age after expected PUBERTY.	""	0	#FFFFFF
D050072	C22.196.963	White Heifer Disease	A congenital reproductive abnormality in white female offspring (heifers) in certain breeds of CATTLE, such as Belgian Blue and Shorthorn. The white color is inherited as a recessive trait which is associated with defects in the female reproductive tract (Muellerian system). These heifers are usually sterile.	""	0	#FFFFFF
D050090	C12.050.351.875.253.343|C12.200.706.316.343|C12.800.316.343|C16.131.939.316.343|C19.391.119.343	Ovotesticular Disorders of Sex Development	Conditions of sexual ambiguity in which the individual possesses gonadal tissues of both sexes, tissues from the OVARY and the TESTIS. There can be a testis on one side and an ovary on the other (lateral), or there may be combined ovarian and testicular tissue (ovotestes) on each side (bilateral). The karyotype may be 46,XX; 46,XY; or a mosaic of 46,XX/46,XY. These disorders have historically been called true hermaphroditism.	""	0	#FFFFFF
D050171	C18.452.584.500	Dyslipidemias	Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.	""	0	#FFFFFF
D050174	C16.320.338	Genetic Diseases, Y-Linked	Genetic diseases that are linked to mutant ALLELES on the Y CHROMOSOME in humans (Y CHROMOSOME, HUMAN) or the Y chromosome in other species. Included here are animal models of human Y-linked diseases.	""	0	#FFFFFF
D050177	C18.654.726.750|C23.888.144.699	Overweight	"A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal ""over fat""."	""	0	#FFFFFF
D050197	C14.907.137.126.307	Atherosclerosis	A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	""	0	#FFFFFF
D050336	C05.116.099.343.796|C16.320.240.875	Mulibrey Nanism	Growth failure from birth that is due to mutations in a gene (TRIM37) on chromosome 17q22-q23 which encodes a RING-B-box-coiled-coil protein.	""	0	#FFFFFF
D050379	C14.907.137.126.056	Arteriolosclerosis	Thickening of the walls of small ARTERIES or ARTERIOLES due to cell proliferation or HYALINE deposition.	""	0	#FFFFFF
D050380	C18.452.174.130.780.500	Monckeberg Medial Calcific Sclerosis	Thickening and loss of elasticity of the walls of muscular ARTERIES due to calcification of the TUNICA MEDIA, the concentric layers of helically arranged SMOOTH MUSCLE CELLS.	""	0	#FFFFFF
D050398	C04.588.149.030|C05.116.231.030	Adamantinoma	A locally aggressive, osteolytic neoplasm of the long bones, probably of epithelial origin and most often involving the TIBIA.	""	0	#FFFFFF
D050488	C05.330.612	Hallux Varus	Displacement of the great toe (HALLUX) towards the midline or away from the other TOES. It can be congenital or acquired.	""	0	#FFFFFF
D050489	C05.330.488.050.500	Bunion, Tailor's	Abnormal swelling of the outer aspect of the fifth metatarsal head affecting the fifth METATARSOPHALANGEAL JOINT.	""	0	#FFFFFF
D050497	C12.050.703.223.650|C23.550.260.585.630	Stillbirth	The event that a FETUS is born dead or stillborn.	""	0	#FFFFFF
D050500	C06.689.750.830|C23.550.291.500.750	Pancreatitis, Chronic	INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.	""	0	#FFFFFF
D050723	C26.404	Fractures, Bone	Breaks in bones.	""	0	#FFFFFF
D050724	C26.411	Fractures, Cartilage	Breaks in CARTILAGE.	""	0	#FFFFFF
D050738	C01.610.600	Mesomycetozoea Infections	Infections by MESOMYCETOZOEA, general or unspecified.	""	0	#FFFFFF
D050798	C10.228.140.546.399.937.875	SUNCT Syndrome	A primary headache disorder that is characterized by frequent short-lasting, unilateral, neuralgiform pain attacks in the ocular area, with CONJUNCTIVA fluid-filling and tearing. SUNCT syndrome is usually resistant to treatment.	""	0	#FFFFFF
D050805	C15.604.744.954	Wandering Spleen	A congenital or acquired condition in which the SPLEEN is not in its normal anatomical position but moves about in the ABDOMEN. This is due to laxity or absence of suspensory ligaments which normally provide peritoneal attachments to keep the SPLEEN in a fixed position. Clinical symptoms include ABDOMINAL PAIN, splenic torsion and ISCHEMIA.	""	0	#FFFFFF
D050815	C26.404.195	Fractures, Compression	Crumbling or smashing of cancellous BONE by forces acting parallel to the long axis of bone. It is applied particularly to vertebral body fractures (SPINAL FRACTURES). (Blauvelt and Nelson, A Manual of Orthopedic Terminology, 1994, p4)	""	0	#FFFFFF
D051261	C07.465.353|C23.550.384	Granulomatosis, Orofacial	A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. Among experts there is disagreement on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease.	""	0	#FFFFFF
D051270	C10.228.140.546.399	Headache Disorders, Primary	Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes.	""	0	#FFFFFF
D051271	C10.228.140.546.699	Headache Disorders, Secondary	Conditions with HEADACHE symptom that can be attributed to a variety of causes including BRAIN VASCULAR DISORDERS; WOUNDS AND INJURIES; INFECTION; drug use or its withdrawal.	""	0	#FFFFFF
D051298	C10.228.140.546.699.249	Post-Traumatic Headache	Secondary headache attributed to TRAUMA of the HEAD and/or the NECK.	""	0	#FFFFFF
D051299	C10.228.140.546.699.124	Post-Dural Puncture Headache	A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.	""	0	#FFFFFF
D051302	C10.228.140.546.399.937.750	Paroxysmal Hemicrania	A primary headache disorder that is similar to the CLUSTER HEADACHE with unilateral head pain, but differs by its multiple short severe attacks. It is usually seen in females, and may be responsive to non-steroidal-anti-inflammatory drugs (NSAIDS).	""	0	#FFFFFF
D051303	C10.228.140.546.399.937	Trigeminal Autonomic Cephalalgias	Primary headache disorders that show symptoms caused by the activation of the AUTONOMIC NERVOUS SYSTEM of the TRIGEMINAL NERVE. These autonomic features include redness and tearing of the EYE, nasal congestion or discharge, facial SWEATING and other symptoms. Most subgroups show unilateral cranial PAIN.	""	0	#FFFFFF
D051346	C23.888.550	Mobility Limitation	Difficulty in walking from place to place.	""	0	#FFFFFF
D051359	C15.604.250.410.575	Lymphohistiocytosis, Hemophagocytic	A group of related disorders characterized by LYMPHOCYTOSIS; HISTIOCYTOSIS; and hemophagocytosis. The two major forms are familial and reactive.	""	0	#FFFFFF
D051436	C12.050.351.968.419.780.750|C12.200.777.419.780.750|C12.950.419.780.750|C23.550.291.500.906	Renal Insufficiency, Chronic	Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)	""	0	#FFFFFF
D051437	C12.050.351.968.419.780|C12.200.777.419.780|C12.950.419.780	Renal Insufficiency	Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.	""	0	#FFFFFF
D051474	C10.668.829.600.550|C23.888.592.612.664.550	Neuralgia, Postherpetic	Pain in nerves, frequently involving facial SKIN, resulting from the activation the latent varicella-zoster virus (HERPESVIRUS 3, HUMAN). The two forms of the condition preceding the pain are HERPES ZOSTER OTICUS; and HERPES ZOSTER OPHTHALMICUS. Following the healing of the rashes and blisters, the pain sometimes persists.	""	0	#FFFFFF
D051516	C12.100.500.293|C12.200.294.293	Hemospermia	Blood in the SEMEN, usually due to INFLAMMATION of the PROSTATE, the SEMINAL VESICLES, or both.	""	0	#FFFFFF
D051527	C04.557.695.607	Odontogenic Tumor, Squamous	A well-differentiated, benign, hamartomatous proliferation of odontogenic epithelium, probably arising from the rests of Malassez.	""	0	#FFFFFF
D051556	C16.614.451|C23.550.429.249	Hyperbilirubinemia, Neonatal	Accumulation of BILIRUBIN, a breakdown product of HEME PROTEINS, in the BLOOD during the first weeks of life. This may lead to NEONATAL JAUNDICE. The excess bilirubin may exist in the unconjugated (indirect) or the conjugated (direct) form. The condition may be self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) or pathological with toxic levels of bilirubin.	""	0	#FFFFFF
D051642	C04.557.450.565.590.425	Histiocytoma	A neoplasm containing HISTIOCYTES. Important forms include BENIGN FIBROUS HISTIOCYTOMA; and MALIGNANT FIBROUS HISTIOCYTOMA.	""	0	#FFFFFF
D051677	C04.557.450.565.590.425.360|C04.557.450.795.400	Histiocytoma, Malignant Fibrous	The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.	""	0	#FFFFFF
D051799	C23.550.277	Delayed Graft Function	General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.	""	0	#FFFFFF
D052016	C06.405.205.798|C07.465.584	Mucositis	An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).	""	0	#FFFFFF
D052065	C12.050.351.500.894.870|C12.050.351.500.919|C12.100.250.894.870|C12.100.250.919|C12.100.875.871	Vaginismus	Recurrent or persistent involuntary SPASM of the outer muscles of the VAGINA, occurring during vaginal penetration.	""	0	#FFFFFF
D052120	C10.597.606.360.455.562|C14.280.238.458|C16.320.322.201|C16.320.565.202.449.510|C18.452.648.202.449.510	Glycogen Storage Disease Type IIb	An X-linked dominant multisystem disorder resulting in cardiomyopathy, myopathy and INTELLECTUAL DISABILITY. It is caused by mutation in the gene encoding LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2.	""	0	#FFFFFF
D052159	C12.050.351.875.253.096.624|C12.050.351.968.419.780.750.500.500|C12.200.706.316.096.624|C12.200.777.419.780.750.500.500|C12.800.316.096.624|C12.950.419.780.750.500.500|C16.131.939.316.096.624|C16.320.306|C19.391.119.096.624|C23.550.291.500.906.500.500	Frasier Syndrome	A syndrome characterized by CHRONIC KIDNEY FAILURE and GONADAL DYSGENESIS in phenotypic females with karyotype of 46,XY or female individual with a normal 46,XX karyotype. It is caused by donor splice-site mutations of Wilms tumor suppressor gene (GENES, WILMS TUMOR) on chromosome 11.	""	0	#FFFFFF
D052177	C12.050.351.968.419.403|C12.200.777.419.403|C12.950.419.403	Kidney Diseases, Cystic	A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilaterally (KIDNEY, CYSTIC).	""	0	#FFFFFF
D052178	C12.050.703.420.235	Cephalopelvic Disproportion	A condition in which the HEAD of the FETUS is larger than the mother's PELVIS through which the fetal head must pass during a vaginal delivery.	""	0	#FFFFFF
D052202	C12.050.351.500.894.500|C12.100.250.894.500	Hydrocolpos	A fluid-filled VAGINA that is obstructed.	""	0	#FFFFFF
D052245	C09.218.458.341.186.500.500|C09.218.458.341.887.886|C10.597.751.418.341.186.500.500|C10.597.751.418.341.887.886|C10.597.751.941.162.625.500|C11.768.585.658.500.813|C11.966.075.375.500|C16.131.077.299.500|C16.320.290.684.500|C23.888.592.763.393.341.887.886	Usher Syndromes	Autosomal recessive hereditary disorders characterized by congenital SENSORINEURAL HEARING LOSS and RETINITIS PIGMENTOSA. Genetically and symptomatically heterogeneous, clinical classes include type I, type II, and type III. Their severity, age of onset of retinitis pigmentosa and the degree of vestibular dysfunction are variable.	""	0	#FFFFFF
D052256	C05.651.869|C26.874.800	Tendinopathy	Clinical syndrome describing overuse tendon injuries characterized by a combination of PAIN, diffuse or localized swelling, and impaired performance.	""	0	#FFFFFF
D052439	C18.452.584	Lipid Metabolism Disorders	Pathological conditions resulting from abnormal anabolism or catabolism of lipids in the body.	""	0	#FFFFFF
D052456	C16.320.565.398.500.330|C18.452.584.500.875.330|C18.452.584.563.500.330|C18.452.648.398.500.330	Hypoalphalipoproteinemias	Conditions with abnormally low levels of ALPHA-LIPOPROTEINS (high-density lipoproteins) in the blood. Hypoalphalipoproteinemia can be associated with mutations in genes encoding APOLIPOPROTEIN A-I; LECITHIN CHOLESTEROL ACYLTRANSFERASE; and ATP-BINDING CASSETTE TRANSPORTERS.	""	0	#FFFFFF
D052476	C18.452.584.500.875.440.750|C18.452.584.563.497	Hypobetalipoproteinemia, Familial, Apolipoprotein B	An autosomal dominant disorder of lipid metabolism. It is caused by mutations of APOLIPOPROTEINS B, main components of CHYLOMICRONS and BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include abnormally low LDL, normal triglyceride level, and dietary fat malabsorption.	""	0	#FFFFFF
D052496	C16.320.488.813|C17.800.849.391.700|C18.452.584.563.798|C18.452.584.625.700|C18.452.880.391.700	Lipodystrophy, Familial Partial	Inherited conditions characterized by the partial loss of ADIPOSE TISSUE, either confined to the extremities with normal or increased fat deposits on the face, neck and trunk (type 1), or confined to the loss of SUBCUTANEOUS FAT from the limbs and trunk (type 2). Type 3 is associated with mutation in the gene encoding PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA.	""	0	#FFFFFF
D052497	C16.320.565.398.745|C17.800.849.391.550|C18.452.584.563.745|C18.452.584.625.550|C18.452.648.398.745|C18.452.880.391.550	Lipodystrophy, Congenital Generalized	Congenital disorders, usually autosomal recessive, characterized by severe generalized lack of ADIPOSE TISSUE, extreme INSULIN RESISTANCE, and HYPERTRIGLYCERIDEMIA.	""	0	#FFFFFF
D052516	C10.228.140.163.100.435.825.850|C16.320.565.189.435.825.850|C16.320.565.398.641.803.925|C16.320.565.595.554.825.850|C18.452.132.100.435.825.850|C18.452.584.563.641.803.925|C18.452.648.189.435.825.850|C18.452.648.398.641.803.925|C18.452.648.595.554.825.850	Sulfatidosis	A group of inherited metabolic disorders characterized by the intralysosomal accumulation of sulfur-containing lipids (SULFATIDES), including SULFOGLYCOSPHINGOLIPIDS normally found in the MYELIN SHEATH of the brain. These disorders are caused by defective degradative enzymes leading to substrate accumulation (or storage).	""	0	#FFFFFF
D052517	C10.228.140.163.100.435.825.850.750|C16.320.565.189.435.825.850.750|C16.320.565.398.641.803.925.750|C16.320.565.595.554.825.850.750|C18.452.132.100.435.825.850.750|C18.452.584.563.641.803.925.750|C18.452.648.189.435.825.850.750|C18.452.648.398.641.803.925.750|C18.452.648.595.554.825.850.750	Multiple Sulfatase Deficiency Disease	An inherited metabolic disorder characterized by the intralysosomal accumulation of sulfur-containing lipids (sulfatides) and MUCOPOLYSACCHARIDES. Excess levels of both substrates are present in urine. This is a disorder of multiple sulfatase (arylsulfatases A, B, and C) deficiency which is caused by the mutation of sulfatase-modifying factor-1. Neurological deterioration is rapid.	""	0	#FFFFFF
D052536	C10.228.140.163.100.435.825.700.500|C15.604.250.410.625.500|C16.320.565.189.435.825.700.500|C16.320.565.398.641.803.730.500|C16.320.565.595.554.825.700.500|C18.452.132.100.435.825.700.500|C18.452.584.563.641.803.730.500|C18.452.648.189.435.825.700.500|C18.452.648.398.641.803.730.500|C18.452.648.595.554.825.700.500	Niemann-Pick Disease, Type A	The classic infantile form of Niemann-Pick Disease, caused by mutation in SPHINGOMYELIN PHOSPHODIESTERASE. It is characterized by accumulation of SPHINGOMYELINS in the cells of the MONONUCLEAR PHAGOCYTE SYSTEM and other cell throughout the body leading to cell death. Clinical signs include JAUNDICE, hepatosplenomegaly, and severe brain damage.	""	0	#FFFFFF
D052537	C10.228.140.163.100.435.825.700.750|C15.604.250.410.625.750|C16.320.565.189.435.825.700.750|C16.320.565.398.641.803.730.750|C16.320.565.595.554.825.700.750|C18.452.132.100.435.825.700.750|C18.452.584.563.641.803.730.750|C18.452.648.189.435.825.700.750|C18.452.648.398.641.803.730.750|C18.452.648.595.554.825.700.750	Niemann-Pick Disease, Type B	An allelic disorder of TYPE A NIEMANN-PICK DISEASE, a late-onset form. It is also caused by mutation in SPHINGOMYELIN PHOSPHODIESTERASE but clinical signs involve only visceral organs (non-neuropathic type).	""	0	#FFFFFF
D052556	C10.228.140.163.100.435.825.700.875|C15.604.250.410.625.875|C16.320.565.189.435.825.700.875|C16.320.565.398.641.803.730.875|C16.320.565.595.554.825.700.875|C18.452.132.100.435.825.700.875|C18.452.584.563.641.803.730.875|C18.452.648.189.435.825.700.875|C18.452.648.398.641.803.730.875|C18.452.648.595.554.825.700.875	Niemann-Pick Disease, Type C	An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes  a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.	""	0	#FFFFFF
D052582	C05.651.869.816.800	Trigger Finger Disorder	A painful disability in the hand affecting the finger or thumb. It is caused by mechanical impingement of the digital flexor tendons as they pass through a narrowed retinacular pulley at the level of the metacarpal head. Thickening of the sheath and fibrocartilaginous metaplasia can occur, and nodules can form. (From Green's Operative Hand Surgery, 5th ed, p2137-58).	""	0	#FFFFFF
D052776	C12.050.351	Female Urogenital Diseases	Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).	""	0	#FFFFFF
D052798	C12.100.500.494.136.500|C12.200.294.494.136.500	Balanitis Xerotica Obliterans	An atrophic and sclerotic condition of the head of the PENIS, glans penis. Sometimes it leads to stenosis and occasionally obliteration of the external meatal orifice.	""	0	#FFFFFF
D052801	C12.200	Male Urogenital Diseases	Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).	""	0	#FFFFFF
D052858	C12.050.351.968.829.508|C12.200.777.829.707|C12.950.829.508|C23.300.842.624.249	Cystocele	A HERNIA-like condition in which the weakened pelvic muscles cause the URINARY BLADDER to drop from its normal position. Fallen urinary bladder is more common in females with the bladder dropping into the VAGINA and less common in males with the bladder dropping into the SCROTUM.	""	0	#FFFFFF
D052878	C12.050.351.968.967|C12.200.777.967|C12.950.967	Urolithiasis	Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.	""	0	#FFFFFF
D052879	C10.228.854.811|C10.314.875|C10.574.910|C18.654.521.500.133.699.923.640|C23.550.737.625	Subacute Combined Degeneration	A neuropathy due to VITAMIN B 12 DEFICIENCY or to excessive NITROUS OXIDE inhalation. It is associated with overproduction of the myelinolytic TUMOR NECROSIS FACTOR-ALPHA.	""	0	#FFFFFF
D052880	C01.830.767|C05.651.594.909|C10.668.491.562.787	Pyomyositis	An intramuscular suppuration of the large skeletal muscle groups. It is associated with INFECTION such as STAPHYLOCOCCUS AUREUS and PYODERMA. It was known as a tropical disease but is increasing among the immunocompromised (IMMUNOCOMPROMISED HOST). Symptoms include muscle pain, FEVER, and leucocytosis. It has been diagnosed by MRI SCANS.	""	0	#FFFFFF
D052919	C10.228.140.163.100.844|C16.320.565.189.844|C16.320.565.663.865|C18.452.132.100.844|C18.452.648.189.844|C18.452.648.663.865	Refsum Disease, Infantile	An early onset form of phytanic acid storage disease with clinical and biochemical signs different from those of REFSUM DISEASE. Features include MENTAL RETARDATION; SENSORINEURAL HEARING LOSS; OSTEOPOROSIS; and severe liver damage. It can be caused by mutation in a number of genes encoding proteins involving in the biogenesis or assembly of PEROXISOMES.	""	0	#FFFFFF
D052958	C04.182.872|C10.668.829.900	Tarlov Cysts	Perineurial cysts commonly found in the SACRAL REGION. They arise from the PERINEURIUM membrane within the SPINAL NERVE ROOTS. The distinctive feature of the cysts is the presence of spinal nerve root fibers within the cyst wall, or the cyst cavity itself.	""	0	#FFFFFF
D053018	C12.050.351.968.419.307.500|C12.200.777.419.307.500|C12.950.419.307.500	Pyonephrosis	Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.	""	0	#FFFFFF
D053039	C12.050.351.968.725.938|C12.050.351.968.967.374|C12.200.777.725.938|C12.200.777.967.374|C12.950.725.938|C12.950.967.374	Ureterolithiasis	Formation of stones in the URETER.	""	0	#FFFFFF
D053040	C12.050.351.968.419.600|C12.050.351.968.967.249|C12.200.777.419.600|C12.200.777.967.249|C12.950.419.600|C12.950.967.249	Nephrolithiasis	Formation of stones in the KIDNEY.	""	0	#FFFFFF
D053098	C05.116.198.816.875.500|C12.050.351.968.419.815.647.500|C12.200.777.419.815.647.500|C12.950.419.815.647.500|C16.320.565.618.544.500|C16.320.831.647.500|C18.452.104.816.875.500|C18.452.174.845.875.500|C18.452.648.618.544.500|C18.452.750.400.500.500|C18.452.750.400.750.500|C18.654.521.500.133.770.734.875.500	Familial Hypophosphatemic Rickets	A hereditary disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; renal defects in phosphate reabsorption and vitamin D metabolism; and growth retardation. Autosomal and X-linked dominant and recessive variants have been reported.	""	0	#FFFFFF
D053099	C12.050.351.968.419.936.231|C12.200.777.419.936.231|C12.950.419.936.231|C23.550.145	Azotemia	A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.	""	0	#FFFFFF
D053120	C08.618.749|C23.550.773	Respiratory Aspiration	Inhaling liquid or solids, such as stomach contents, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA.	""	0	#FFFFFF
D053158	C23.888.942.343.550	Nocturia	Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS).	""	0	#FFFFFF
D053159	C23.888.942.343.274	Dysuria	Painful URINATION. It is often associated with infections of the lower URINARY TRACT.	""	0	#FFFFFF
D053201	C12.050.351.968.829.813|C12.200.777.829.866|C12.950.829.813|C23.888.942.343.780	Urinary Bladder, Overactive	Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.	""	0	#FFFFFF
D053202	C12.050.351.968.934.814.750|C12.200.777.934.852.500|C12.950.934.814.750|C23.888.942.343.800.750	Urinary Incontinence, Urge	Involuntary discharge of URINE that is associated with an abrupt and strong desire to void. It is usually related to the involuntary contractions of the detrusor muscle of the bladder (detrusor hyperreflexia or detrusor instability).	""	0	#FFFFFF
D053206	C12.050.351.968.934.252.500|C12.200.777.934.284.500|C12.950.934.252.500	Nocturnal Enuresis	Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.	""	0	#FFFFFF
D053207	C12.050.351.968.934.252.249|C12.200.777.934.284.249|C12.950.934.252.249	Diurnal Enuresis	Involuntary discharge of URINE during the daytime while one is awake.	""	0	#FFFFFF
D053306	C15.378.147.333.249|C16.320.413|C16.320.798.625|C20.673.430.250|C20.673.795.625	Hyper-IgM Immunodeficiency Syndrome	A rare inherited immunodeficiency syndrome characterized by normal or elevated serum IMMUNOGLOBULIN M levels with absence of IMMUNOGLOBULIN G; IMMUNOGLOBULIN A; and IMMUNOGLOBULIN E. It results in a profound susceptibility to BACTERIAL INFECTIONS and an increased susceptibility to OPPORTUNISTIC INFECTIONS. Several subtypes of hyper-IgM immunodeficiency syndrome exist depending upon the location of genetic mutation.	""	0	#FFFFFF
D053307	C15.378.147.333.249.500|C16.320.322.237|C16.320.798.625.500|C20.673.430.250.500|C20.673.795.625.500	Hyper-IgM Immunodeficiency Syndrome, Type 1	An X-linked hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding CD40 LIGAND.	""	0	#FFFFFF
D053358	C16.131.077.350.198|C16.131.831.350.198|C16.320.322.116|C16.320.850.250.198|C17.800.804.350.198|C17.800.827.250.198	Ectodermal Dysplasia 1, Anhidrotic	An X-linked form of ectodermal dysplasia which results from mutations of the gene encoding ECTODYSPLASIN.	""	0	#FFFFFF
D053359	C16.131.077.350.298|C16.131.831.350.298|C16.320.850.250.298|C17.800.804.350.298|C17.800.827.250.298	Ectodermal Dysplasia 3, Anhidrotic	An autosomal dominant form of ectodermal dysplasia which is due to mutations in the gene for the EDAR RECEPTOR.	""	0	#FFFFFF
D053360	C16.131.077.350.348|C16.131.831.350.348|C16.320.850.250.348|C17.800.804.350.348|C17.800.827.250.348	Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive	An autosomal recessive form of ectodermal dysplasia which is due to mutations in the gene for the EDAR RECEPTOR or EDAR-ASSOCIATED DEATH DOMAIN PROTEIN.	""	0	#FFFFFF
D053421	C10.668.829.380|C14.907.440|C24.400	Hand-Arm Vibration Syndrome	An occupational disorder resulting from prolonged exposure to vibration, affecting the fingers, hands, and forearms. It occurs in workers who regularly use vibrating tools such as jackhammers, power chain saws, riveters, etc. Symptoms include episodic finger blanching, NUMBNESS, tingling, and loss of nerve sensitivity.	""	0	#FFFFFF
D053447	C23.550.177	Channelopathies	A variety of neuromuscular conditions resulting from MUTATIONS in ION CHANNELS manifesting as episodes of EPILEPSY; HEADACHE DISORDERS; and DYSKINESIAS.	""	0	#FFFFFF
D053448	C23.888.942.343.600	Prostatism	Lower urinary tract symptom, such as slow urinary stream, associated with PROSTATIC HYPERPLASIA in older men.	""	0	#FFFFFF
D053489	C01.925.256.700.550|C22.557	Mink Viral Enteritis	A highly contagious parvovirus infection in mink, caused by MINK ENTERITIS VIRUS or the closely related FELINE PANLEUKOPENIA VIRUS or CANINE PARVOVIRUS. Transmission usually occurs by the fecal/oral route.	""	0	#FFFFFF
D053529	C16.320.850.542|C17.800.827.595	Leukokeratosis, Hereditary Mucosal	An autosomal dominant disorder that is manifested by thickened spongiform ORAL MUCOSA with a white opalescent tint. Other MUCOSAL TISSUE may also be involved mucosa found in the VAGINA; RECTUM, and NASAL CAVITY may be similarly involved. This form of LEUKOKERATOSIS can be caused by a mutation in the gene for KERATIN 4 and is not considered a PRENEOPLASTIC CONDITION.	""	0	#FFFFFF
D053546	C16.320.850.475.440.500|C17.800.428.435.440.500|C17.800.827.475.440.500	Keratoderma, Palmoplantar, Epidermolytic	An autosomal dominant hereditary skin disease characterized by epidermolytic hyperkeratosis that is strictly confined to the palms and soles. It has been associated with mutations in the gene that codes for KERATIN-9.	""	0	#FFFFFF
D053549	C16.131.077.350.856|C16.131.831.350.856|C16.320.850.250.856|C17.800.529.594|C17.800.804.350.856|C17.800.827.250.856	Pachyonychia Congenita	A group of inherited ectodermal dysplasias whose most prominent clinical feature is hypertrophic nail dystrophy resulting in PACHYONYCHIA. Several specific subtypes of pachyonychia congenita have been associated with mutations in genes that encode KERATINS.	""	0	#FFFFFF
D053559	C11.204.236.218|C11.270.162.218|C16.320.290.162.204	Corneal Dystrophy, Juvenile Epithelial of Meesmann	An autosomal dominant form of hereditary corneal dystrophy due to a defect in cornea-specific KERATIN formation. Mutations in the genes that encode KERATIN-3 and KERATIN-12 have been linked to this disorder.	""	0	#FFFFFF
D053560	C16.131.831.512.408|C16.320.850.402|C16.614.492.410|C17.800.428.333.330|C17.800.804.512.405|C17.800.827.403	Ichthyosis Bullosa of Siemens	An autosomal dominant form of ichthyosis characterized by generalized reddening of the skin (ERYTHEMA) and widespread blistering. The disease shows similar, but somewhat milder, clinical and histopathological findings to those in HYPERKERATOSIS, EPIDERMOLYTIC and is associated with the gene that encodes KERATIN-2A.	""	0	#FFFFFF
D053565	C23.888.942.337	Hypercalciuria	Excretion of abnormally high level of CALCIUM in the URINE, greater than 4 mg/kg/day.	""	0	#FFFFFF
D053570	C01.925.256.200.500|C22.905.690	Porcine Postweaning Multisystemic Wasting Syndrome	A worldwide emerging disease of weaned piglets first recognized in swine herds in western Canada in 1997. This syndrome is characterized by progressive weight loss, rapid (tachypnea) and difficult (dyspnea) breathing, and yellowing of skin. PMWS is caused by PORCINE CIRCOVIRUS infection, specifically type 2 or PCV-2.	""	0	#FFFFFF
D053578	C04.588.614.550.600|C04.730.856.596|C10.228.758.500|C10.292.562.831|C10.574.781.662|C10.597.350.500.500|C11.590.725	Opsoclonus-Myoclonus Syndrome	A neurological condition that is characterized by uncontrolled rapid irregular movements of the eye (OPSOCLONUS) and the muscle (MYOCLONUS) causing unsteady, trembling gait. It is also known as dancing eyes-dancing feet syndrome and is often associated with neoplasms, viral infections, or autoimmune disorders involving the nervous system.	""	0	#FFFFFF
D053579	C12.050.351.968.419.815.491|C12.200.777.419.815.491|C12.950.419.815.491|C16.320.831.491	Gitelman Syndrome	An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.	""	0	#FFFFFF
D053584	C23.888.942.900	Urinoma	An encapsulated accumulation of URINE in the retroperitoneal area. It has the appearance of a cyst (CYSTS). Urinoma is usually caused by URETERAL OBSTRUCTION, renal trauma or perforation of the renal collecting system.	""	0	#FFFFFF
D053589	C12.050.703.413|C16.300.790	Nuchal Cord	A complication of pregnancy in which the UMBILICAL CORD wraps around the fetal neck once or multiple times. In some cases, cord entanglement around fetal neck may not affect pregnancy outcome significantly. In others, the nuchal cord may lead to restricted fetal blood flow, oxygen transport, fetal development, fetal movement, and complicated delivery at birth.	""	0	#FFFFFF
D053591	C23.888.592.612.888	Pain, Referred	A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear.	""	0	#FFFFFF
D053608	C10.597.606.358.800.500|C23.888.592.604.359.800.500	Stupor	A state of reduced sensibility and response to stimuli which is distinguished from COMA in that the person can be aroused by vigorous and repeated stimulation. The person is still conscious and can make voluntary movements. It can be induced by CENTRAL NERVOUS SYSTEM AGENTS. The word derives from Latin stupere and is related to stunned, stupid, dazed or LETHARGY.	""	0	#FFFFFF
D053609	C10.597.606.441|C23.888.592.604.444	Lethargy	A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.	""	0	#FFFFFF
D053627	C12.100.500.430.253|C12.100.750.700.253|C12.200.294.430.253	Asthenozoospermia	A condition in which the percentage of motile sperm is abnormally low.	""	0	#FFFFFF
D053632	C16.320.322.968|C16.320.798.750.500|C16.614.815.500|C20.673.795.750.500	X-Linked Combined Immunodeficiency Diseases	Forms of combined immunodeficiency caused by mutations in the gene for INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT. Both severe and non-severe subtypes of the disease have been identified.	""	0	#FFFFFF
D053653	C12.050.351.968.419.570.821.358|C12.050.351.968.829.495.750|C12.200.777.419.570.821.358|C12.200.777.829.495.750|C12.950.419.570.821.358|C12.950.829.495.750	Pyelocystitis	Inflammation of the KIDNEY PELVIS and the URINARY BLADDER.	""	0	#FFFFFF
D053682	C05.651.869.816	Tendon Entrapment	Narrowing or stenosis of a tendon's retinacular sheath. It occurs most often in the hand or wrist but can also be found in the foot or ankle. The most common types are DE QUERVAIN DISEASE and TRIGGER FINGER DISORDER.	""	0	#FFFFFF
D053684	C05.651.869.816.200	De Quervain Disease	Stenosing tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons in the first dorsal wrist compartment. The presenting symptoms are usually pain and tenderness at the radial styloid. The cause is almost always related to OVERUSE INJURY or is associated with RHEUMATOID ARTHRITIS.	""	0	#FFFFFF
D053706	C01.463.850|C06.405.205.596.750.500|C06.405.469.110.708	Typhlitis	"Necrotizing inflammation of the CECUM (""typhlon"" in Greek), sometimes spreading to the APPENDIX and/or the ILEUM. Symptoms include ABDOMINAL PAIN and DIARRHEA. Its pathogenesis is multifactorial. Typhlitis is often associated with NEUTROPENIA and chemotherapy in immunocompromised individuals (IMMUNOCOMPROMISED HOST)."	""	0	#FFFFFF
D053713	C12.100.500.430.380|C12.100.750.700.380|C12.200.294.430.380	Azoospermia	A condition of having no sperm present in the ejaculate (SEMEN).	""	0	#FFFFFF
D053714	C12.100.500.430.126|C12.100.750.700.126|C12.200.294.430.126	Aspermia	A condition characterized by the complete absence of SEMEN. This disorder should be differentiated from AZOOSPERMIA, absence of sperm in the semen.	""	0	#FFFFFF
D053717	C01.248.250.500|C01.748.610.300.500|C08.381.677.300.500|C08.730.610.300.500|C23.550.291.875.500.500.500	Pneumonia, Ventilator-Associated	Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by bacterial CROSS INFECTION in hospitals.	""	0	#FFFFFF
D053718	C17.300.550.875	Scleromyxedema	A connective tissue disorder characterized by widespread thickening of SKIN with a cobblestone-like appearance. It is caused by proliferation of FIBROBLASTS and deposition of MUCIN in the DERMIS in the absence of thyroid disease. Most scleromyxedema cases are associated with a MONOCLONAL GAMMOPATHY, immunoglobulin IgG-lambda.	""	0	#FFFFFF
D053821	C01.190|C14.260	Cardiovascular Infections	Pathological conditions of the CARDIOVASCULAR SYSTEM caused by infections.	""	0	#FFFFFF
D053836	C23.550.717.273	DNA Degradation, Necrotic	The random catabolism of DNA accompanying the irreversible damage to tissue which leads to the pathological death of one or more cells.	""	0	#FFFFFF
D053840	C14.280.067.322|C14.280.123.250|C16.320.100	Brugada Syndrome	An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.	""	0	#FFFFFF
D053842	C23.550.362.590	Microsatellite Instability	The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.	""	0	#FFFFFF
D054000	C04.557.665.560.700|C10.562.700|C16.131.077.633	Nevus, Sebaceous of Jadassohn	A syndrome characterized by lesions occurring on the face, scalp, or neck which consist of congenital hypoplastic malformations of cutaneous structures and which over time undergo verrucous hyperplasia. Additionally it is associated with neurological symptoms and skeletal, ophthalmological, urogenital, and cardiovascular abnormalities.	""	0	#FFFFFF
D054019	C20.608	Immune Reconstitution Inflammatory Syndrome	Exuberant inflammatory response towards a previously acquired or undiagnosed opportunistic infection. It is frequently seen in AIDS patients following antiretroviral treatment.	""	0	#FFFFFF
D054038	C10.228.140.631.500.500|C10.228.140.695.875	Posterior Leukoencephalopathy Syndrome	A condition that is characterized by HEADACHE; SEIZURES; and visual loss with edema in the posterior aspects of the CEREBRAL HEMISPHERES, such as the BRAIN STEM. Generally, lesions involve the white matter (nerve fibers) but occasionally the grey matter (nerve cell bodies).	""	0	#FFFFFF
D054039	C17.800.529.478	Onycholysis	Separation of nail plate from the underlying nail bed. It can be a sign of skin disease, infection (such as ONYCHOMYCOSIS) or tissue injury.	""	0	#FFFFFF
D054058	C14.280.647.124|C14.907.585.124	Acute Coronary Syndrome	An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.	""	0	#FFFFFF
D054059	C14.280.647.250.272|C14.907.585.250.272	Coronary Occlusion	Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.	""	0	#FFFFFF
D054060	C08.381.746.500|C14.907.355.350.700.500|C23.550.513.355.875|C23.550.717.489.875	Pulmonary Infarction	NECROSIS of lung tissue that is cause by the lack of OXYGEN or blood supply. The most common cause of pulmonary infarction is a blood clot in the lung.	""	0	#FFFFFF
D054061	C05.550.323.734|C05.651.180.531|C05.651.197.734|C14.907.303.531	Ischemic Contracture	A type of permanent damage to muscles and nerves that results from prolonged lack blood flow to those tissues. It is characterized by shortening and stiffening of the muscles.	""	0	#FFFFFF
D054062	C09.218.458.341.186.500|C10.597.751.418.341.186.500|C10.597.751.941.162.625|C11.966.075.375|C16.131.077.299|C23.888.592.763.393.341.186.500|C23.888.592.763.941.162.625	Deaf-Blind Disorders	The absence of both hearing and vision.	""	0	#FFFFFF
D054066	C04.557.337.428.580.049|C15.604.515.560.575.049|C20.683.515.528.582.049	Leukemia, Large Granular Lymphocytic	A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.	""	0	#FFFFFF
D054067	C16.320.565.798.183|C18.452.648.798.183	Dihydropyrimidine Dehydrogenase Deficiency	An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.	""	0	#FFFFFF
D054068	C14.907.617.625|C17.800.862.355|C23.888.885.437	Livedo Reticularis	A condition characterized by a reticular or fishnet pattern on the skin of lower extremities and other parts of the body. This red and blue pattern is due to deoxygenated blood in unstable dermal blood vessels. The condition is intensified by cold exposure and relieved by rewarming.	""	0	#FFFFFF
D054069	C16.320.565.100.614|C18.452.648.100.614|C18.452.660.612	Multiple Acyl Coenzyme A Dehydrogenase Deficiency	An autosomal recessive disorder of fatty acid oxidation, and branched chain amino acids (AMINO ACIDS, BRANCHED-CHAIN); LYSINE; and CHOLINE catabolism, that is due to defects in either subunit of ELECTRON TRANSFER FLAVOPROTEIN or its dehydrogenase, electron transfer flavoprotein-ubiquinone oxidoreductase (EC 1.5.5.1).	""	0	#FFFFFF
D054070	C14.907.355.830.925.462|C14.907.952.880	Postthrombotic Syndrome	A condition caused by one or more episodes of DEEP VEIN THROMBOSIS, usually the blood clots are lodged in the legs. Clinical features include EDEMA; PAIN; aching; heaviness; and MUSCLE CRAMP in the leg. When severe leg swelling leads to skin breakdown, it is called venous STASIS ULCER.	""	0	#FFFFFF
D054078	C10.228.140.163.100.593|C15.378.147.542.319|C16.320.382.750|C16.320.565.189.593|C16.320.565.663.430|C18.452.132.100.593|C18.452.648.189.593|C18.452.648.663.430|C20.683.460.319	Mevalonate Kinase Deficiency	Autosomal recessive disorder caused by mutations in the mevalonate kinase gene. Because of the mutations cholesterol biosynthesis is disrupted and MEVALONIC ACID accumulates. It is characterized by a range of symptoms, including dysmorphic FACIES, psychomotor retardation, CATARACT, hepatosplenomegaly, CEREBELLAR ATAXIA, elevated IMMUNOGLOBULIN D, and recurrent febrile crises with FEVER; LYMPHADENOPATHY; ARTHRALGIA; EDEMA; and rash.	""	0	#FFFFFF
D054079	C14.240.850|C16.131.240.850	Vascular Malformations	A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.	""	0	#FFFFFF
D054080	C10.228.140.300.520.500|C10.500.190.500.500|C14.240.850.750.295.500|C14.240.850.875.500.500|C14.907.150.295.500|C14.907.253.560.400.500|C16.131.240.850.750.295.500|C16.131.240.850.875.500.500|C16.131.666.190.500.500	Vein of Galen Malformations	Congenital arteriovenous malformation involving the VEIN OF GALEN, a large deep vein at the base of the brain. The rush of arterial blood directly into the vein of Galen, without passing through the CAPILLARIES, can overwhelm the heart and lead to CONGESTIVE HEART FAILURE.	""	0	#FFFFFF
D054081	C10.500.507.450|C16.131.666.507.450	Malformations of Cortical Development, Group II	Cortical malformations secondary to abnormal neuronal CELL MIGRATION in NEUROGENESIS. This group includes COBBLESTONE LISSENCEPHALY and PERIVENTRICULAR NODULAR HETEROTOPIA.	""	0	#FFFFFF
D054082	C10.500.507.450.499|C16.131.666.507.450.499	Lissencephaly	A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.	""	0	#FFFFFF
D054083	C14.240.400.422|C16.131.240.400.422	Ectopia Cordis	A rare developmental defect in which the heart is abnormally located partially or totally outside the THORAX. It is the result of defective fusion of the anterior chest wall. Depending on the location of the heart, ectopia cordis can be thoracic, thoracoabdominal, abdominal, and cervical.	""	0	#FFFFFF
D054084	C14.240.400.210.500|C14.280.400.210.500|C16.131.240.400.210.500	Myocardial Bridging	A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.	""	0	#FFFFFF
D054091	C10.500.507.450.750|C16.131.666.507.450.750	Periventricular Nodular Heterotopia	A disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches.	""	0	#FFFFFF
D054092	C14.240.400.560.375.258|C14.280.400.560.375.258|C16.131.240.400.560.375.258	Foramen Ovale, Patent	A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.	""	0	#FFFFFF
D054098	C15.378.140.855.850|C16.614.899	Thrombocytopenia, Neonatal Alloimmune	A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.	""	0	#FFFFFF
D054119	C05.660.585.174|C16.131.621.585.174	Arachnodactyly	An abnormal bone development that is characterized by extra long and slender hands and fingers, such that the clenched thumb extends beyond the ulnar side of the hand. Arachnodactyly can include feet and toes. Arachnodactyly has been associated with several gene mutations and syndromes.	""	0	#FFFFFF
D054138	C14.280.067.093.500|C23.550.073.093.500	Sinus Arrest, Cardiac	The omission of atrial activation that is caused by transient cessation of impulse generation at the SINOATRIAL NODE. It is characterized by a prolonged pause without P wave in an ELECTROCARDIOGRAM. Sinus arrest has been associated with sleep apnea (REM SLEEP-RELATED SINUS ARREST).	""	0	#FFFFFF
D054139	C14.280.067.845.787|C14.280.123.875.787|C23.550.073.845.787	Tachycardia, Reciprocating	Abnormally rapid heartbeats caused by reentrant conduction over the accessory pathways between the HEART ATRIA and the HEART VENTRICLES. The impulse can also travel in the reverse direction, as in some cases, atrial impulses travel to the ventricles over the accessory pathways and back to the atria over the BUNDLE OF HIS and the ATRIOVENTRICULAR NODE.	""	0	#FFFFFF
D054141	C14.280.067.961|C23.550.073.961	Ventricular Flutter	A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance. If untreated, ventricular flutter typically progresses to VENTRICULAR FIBRILLATION.	""	0	#FFFFFF
D054143	C14.280.434.676	Heart Failure, Systolic	Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.	""	0	#FFFFFF
D054144	C14.280.434.611	Heart Failure, Diastolic	Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.	""	0	#FFFFFF
D054160	C23.888.447.500	Systolic Murmurs	Heart murmurs which are systolic in timing. They occur between the first and the second HEART SOUNDS, between the closure of MITRAL VALVE and TRICUSPID VALVE and the closure of semilunar aortic and pulmonary valves. Systolic murmurs include ejection murmurs and regurgitant murmurs.	""	0	#FFFFFF
D054179	C14.907.079.500|C16.320.798.500.500|C17.800.862.945.066.500|C20.543.480.904.066.500|C20.673.795.500.500	Angioedemas, Hereditary	Inherited disorders that are characterized by subcutaneous and submucosal EDEMA in the upper RESPIRATORY TRACT and GASTROINTESTINAL TRACT.	""	0	#FFFFFF
D054198	C04.557.337.428.600|C15.604.515.560.600|C20.683.515.528.600	Precursor Cell Lymphoblastic Leukemia-Lymphoma	A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.	""	0	#FFFFFF
D054218	C04.557.337.428.600.620|C15.604.515.560.600.620|C20.683.515.528.600.620	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.	""	0	#FFFFFF
D054219	C04.557.595	Neoplasms, Plasma Cell	Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.	""	0	#FFFFFF
D054220	C10.500.507|C16.131.666.507	Malformations of Cortical Development	Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.	""	0	#FFFFFF
D054221	C10.500.507.450.230|C10.500.507.450.499.230|C16.131.666.507.450.230|C16.131.666.507.450.499.230|C16.320.322.500.186	Classical Lissencephalies and Subcortical Band Heterotopias	Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)	""	0	#FFFFFF
D054222	C10.500.507.450.499.249|C16.131.666.507.450.249|C16.131.666.507.450.499.249	Cobblestone Lissencephaly	The smooth pebbled appearance of the CEREBRAL CORTEX with a thickened cortex and reduced and abnormal white matter, which results from migration of heterotopic neurons beyond the marginal zone into the leptomeninges through gaps in the external BASEMENT MEMBRANE. There is also enlarged ventricles, underdeveloped BRAINSTEM and cerebellum, and absence of the CORPUS CALLOSUM. These abnormalities occur as a syndrome without other birth defects (cobblestone complex) or in other syndromes associated with congenital MUSCULAR DYSTROPHY, often involving the eye, such as the Walker-Warburg Syndrome, Fukuyama congenital muscular dystrophy, and muscle-eye-brain disease.	""	0	#FFFFFF
D054243	C01.925.782.580.830.825|C07.465.864.968|C22.952	Vesicular Stomatitis	A viral disease caused by at least two distinct species (serotypes) in the VESICULOVIRUS genus: VESICULAR STOMATITIS INDIANA VIRUS and VESICULAR STOMATITIS NEW JERSEY VIRUS. It is characterized by vesicular eruptions on the ORAL MUCOSA in cattle, horses, pigs, and other animals. In humans, vesicular stomatitis causes an acute influenza-like illness.	""	0	#FFFFFF
D054312	C01.150.252.410.040.552.475.247|C17.800.893.295	Buruli Ulcer	A lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa.	""	0	#FFFFFF
D054318	C23.550.513.677	No-Reflow Phenomenon	Markedly reduced or absent REPERFUSION in an infarct zone following the removal of an obstruction or constriction of an artery.	""	0	#FFFFFF
D054319	C10.228.140.163.510|C10.314.475	Marchiafava-Bignami Disease	A neurodegenerative condition that is characterized by demyelination or necrosis of the CORPUS CALLOSUM. Symptoms include DEPRESSION; PARANOIA; DEMENTIA; SEIZURES; and ATAXIA which can progress to COMA and death in a few months. Marchiafava-Bignami syndrome is seen often in alcoholics but has been found in non-alcoholics as well.	""	0	#FFFFFF
D054331	C12.100.500.430.754|C12.100.750.700.754|C12.200.294.430.754	Sertoli Cell-Only Syndrome	A type of male infertility in which no germ cells are visible in any of the biopsied SEMINIFEROUS TUBULES (type I) or in which germ cells are present in a minority of tubules (type II). Clinical features include AZOOSPERMIA, normal VIRILIZATION, and normal chromosomal complement.	""	0	#FFFFFF
D054363	C04.557.450.565.590.797.750|C04.588.894.797.640.800	Solitary Fibrous Tumor, Pleural	A rare neoplasm, usually benign, derived from mesenchymal fibroblasts located in the submesothelial lining of the PLEURA. It spite of its various synonyms, it has no features of mesothelial cells and is not related to malignant MESOTHELIOMA or asbestos exposure.	""	0	#FFFFFF
D054364	C04.557.450.565.590.797	Solitary Fibrous Tumors	Rare neoplasms of mesenchymal origin, usually benign, and most commonly involving the PLEURA (see SOLITARY FIBROUS TUMOR, PLEURAL). They also are found in extrapleural sites.	""	0	#FFFFFF
D054391	C04.557.386.480.750.199	Lymphoma, Extranodal NK-T-Cell	An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites.	""	0	#FFFFFF
D054403	C04.557.337.428.080.562|C04.557.337.428.565.745|C15.604.515.560.080.562|C15.604.515.560.550.745|C20.683.515.528.080.562|C20.683.515.528.565.745	Leukemia, Prolymphocytic, B-Cell	A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.	""	0	#FFFFFF
D054429	C04.557.337.539.525|C15.378.190.615.520	Leukemia, Myelomonocytic, Juvenile	A leukemia affecting young children characterized by SPLENOMEGALY, enlarged lymph nodes, rashes, and hemorrhages. Traditionally classed as a myeloproliferative disease, it is now considered a mixed myeloproliferative-mylelodysplastic disorder.	""	0	#FFFFFF
D054437	C15.378.190.615	Myelodysplastic-Myeloproliferative Diseases	Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.	""	0	#FFFFFF
D054438	C04.557.337.539.300|C15.378.190.615.500|C23.550.291.500.493	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	A myelodysplastic/myeloproliferative disorder characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to CHRONIC MYELOID LEUKEMIA, but cytogenetically lacking a PHILADELPHIA CHROMOSOME or bcr/abl fusion gene (GENES, ABL).	""	0	#FFFFFF
D054446	C04.557.386.480.750.800.507|C15.604.515.569.480.750.800.507|C20.683.515.761.480.750.800.507	Lymphoma, Primary Cutaneous Anaplastic Large Cell	Anaplastic lymphoma of the skin which develops as a primary neoplasm expressing the CD30 ANTIGEN. It is characterized by solitary nodules or ulcerated tumors.	""	0	#FFFFFF
D054463	C16.131.077.899|C16.131.831.874|C16.320.850.895|C17.800.804.874|C17.800.827.895	Trichothiodystrophy Syndromes	Autosomal recessive neuroectodermal disorders characterized by brittle sulfur-deficient hair associated with impaired intellect, decreased fertility, and short stature. It may include nail dystrophy, ICHTHYOSIS, and photosensitivity correlated with a NUCLEOTIDE EXCISION REPAIR defect. All individuals with this disorder have a deficiency of cysteine-rich KERATIN-ASSOCIATED PROTEINS found in the interfilamentous matrix. Photosensitive trichothiodystrophy can be caused by mutation in at least 2 separate genes: ERCC2 PROTEIN gene and the related ERCC3. Nonphotosensitive trichothiodystrophy can be caused by mutation in the TTDN1 gene.	""	0	#FFFFFF
D054506	C17.800.030.575	Chloracne	ACNE-like skin eruptions caused by exposure to CHLORINE-containing compounds. Exposure can be by inhalation, ingestion, or through the skin. Chloracne is often seen in people who have occupational contact with chlorinated pesticides, wood preservatives, and sealants.	""	0	#FFFFFF
D054508	C26.733.188	Acute Radiation Syndrome	A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.	""	0	#FFFFFF
D054514	C11.250.616|C16.131.384.725	Persistent Hyperplastic Primary Vitreous	A developmental ocular anomaly in which the primary VITREOUS BODY and its surrounding hyaloid vasculature failed to regress. It is usually unilateral and characterized by CATARACT; MICROPHTHALMOS (small eyeballs), and retrolenticular fibrovascular tissue. (from Yanoff: Ophthalmology, 2nd ed.)	""	0	#FFFFFF
D054515	C12.050.351.500.944.902.368|C12.100.250.944.902.368	Vulvar Vestibulitis	Inflammation of the vulvar vestibular region at the entrance of the VAGINA, generally involving surface mucosa and submucosal vestibular glands. It is characterized by ERYTHEMA and chronic recurrent pain in this area.	""	0	#FFFFFF
D054517	C11.675.387|C17.300.185.500	Orbital Cellulitis	Inflammation of the loose connective tissues around the ORBIT, bony structure around the eyeball. It is characterized by PAIN; EDEMA of the CONJUNCTIVA; swelling of the EYELIDS; EXOPHTHALMOS; limited eye movement; and loss of vision.	""	0	#FFFFFF
D054537	C14.280.067.558.230|C14.280.123.500.230|C23.550.073.425.062	Atrioventricular Block	Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.	""	0	#FFFFFF
D054546	C10.228.662.262.249.937|C16.320.400.550	Neuroacanthocytosis	An inherited autosomal disorder that is characterized by neurodegeneration; orofacial and buccal DYSKINESIAS; CHOREA; and thorny-looking red cells (ACANTHOCYTES). This disorder is due to mutations of chorein which is important in protein trafficking and is encoded by Vps13a on chromosome 9q21.	""	0	#FFFFFF
D054549	C14.280.945.900.500	Takotsubo Cardiomyopathy	A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.	""	0	#FFFFFF
D054556	C14.907.355.590.700	Venous Thromboembolism	Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.	""	0	#FFFFFF
D054559	C18.452.750.199	Hyperphosphatemia	A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.	""	0	#FFFFFF
D054685	C04.557.386.480.150.592|C15.604.515.569.480.150.592|C20.683.515.761.480.150.592	Lymphoma, Primary Effusion	A rare neoplasm of large B-cells usually presenting as serious effusions without detectable tumor masses. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. It is associated with HUMAN HERPESVIRUS 8, most often occurring in the setting of immunodeficiency.	""	0	#FFFFFF
D054705	C04.557.450.565.465.249.500|C04.557.450.565.465.500.500|C04.588.805.309.500|C17.800.882.356.500|C20.762.750.469.500|C20.762.750.563.500	Mastocytoma, Skin	A variant of cutaneous mastocytosis which occurs as a single lesion usually in infants. It is found mostly in the wrist and trunk and there is no atypical cytomorphology.	""	0	#FFFFFF
D054739	C04.557.227.199|C15.604.250.390.199	Dendritic Cell Sarcoma, Interdigitating	A rare sarcoma of INTERDIGITATING CELLS found in the lymph nodes and non-lymphoid organs. They exhibit a variable immunophenotype and lack Birbeck granules.	""	0	#FFFFFF
D054740	C04.557.227.190|C15.604.250.390.190	Dendritic Cell Sarcoma, Follicular	Sarcoma of FOLLICULAR DENDRITIC CELLS most often found in the lymph nodes. This rare neoplasm occurs predominately in adults.	""	0	#FFFFFF
D054747	C04.557.227.380|C15.604.250.390.380	Histiocytic Sarcoma	Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.	""	0	#FFFFFF
D054752	C04.557.227.500|C15.604.250.390.500	Langerhans Cell Sarcoma	Rare malignant neoplasm of dendritic LANGERHANS CELLS exhibiting atypical cytology, frequent mitoses, and aggressive clinical behavior. They can be distinguished from other histiocytic and dendritic proliferations by immunohistochemical and ultrastructure studies. Cytologically benign proliferations of Langerhans cells are called LANGERHANS CELL HISTIOCYTOSIS.	""	0	#FFFFFF
D054850	C05.116.540.310.800	Osteophyte	Bony outgrowth usually found around joints and often seen in conditions such as ARTHRITIS.	""	0	#FFFFFF
D054853	C14.907.137.520|C14.907.940.530|C17.800.862.457	Malignant Atrophic Papulosis	Variously described as a vasculopathy, endovasculitis, or occlusive arteriopathy, this condition occurs in a benign cutaneous form and a lethal multiorgan systemic variant. It is characterized by a narrowing and occlusion of the lumen of small to medium-sized blood vessels, leading to ischemia and infarction in the involved organ systems. The etiology and pathophysiology are unknown.	""	0	#FFFFFF
D054868	C15.378.140.855.440|C16.131.260.440|C16.320.180.440	Jacobsen Distal 11q Deletion Syndrome	A clinically recognized congenital malformation condition caused by a distal 11q deletion. The features of the syndrome are growth retardation, psychomotor retardation, trigonocephaly, divergent intermittent strabismus, epicanthus, telecanthus, broad nasal bridge, short nose with anteverted nostrils, carp-shaped upper lip, retrognathia, low-set dysmorphic ears, bilateral camptodactyly, and hammertoes. Platelet dysfunction is a feature in Paris-Trousseau type thrombocytopenia.	""	0	#FFFFFF
D054877	C16.131.077.944|C16.131.260.985|C16.320.180.985	Wolf-Hirschhorn Syndrome	"A syndrome caused by large deletions of the telomereic end of the short arm of CHROMOSOME 4 (4p) in Wolf-Hirchhorn syndrome critial regions (WHSCRs). Several candidate genes have been identified including WHSC1 and WHSCH2 which appear to be responsible for the core phenotype and in combination with other linked and unlinked genes determine the severity and inclusion of rarer phenotypes. Most cases have a characteristic cranio-facial defect often referred to as ""Greek helmet face"" - a combined result of MICROCEPHALY, broad forehead, prominent glabella, HYPERTELORISM, high arched eyebrows, short philtrum and micrognathia. In addition there is mental retardation, growth delays, EPILEPSY, and frequently a wide range of midline and skeletal defects, including HYPOSPADIAS; CONGENITAL HEART DEFECTS; CLEFT LIP; CLEFT PALATE; colobomata; CLUBFOOT; clinodactyly; SCOLIOSIS; and KYPHOSIS."	""	0	#FFFFFF
D054880	C16.320.565.595.100|C18.452.648.595.100	Aspartylglucosaminuria	A recessively inherited, progressive lysosomal storage disease caused by a deficiency of GLYCOSYLASPARAGINASE activity. The lack of this enzyme activity results in the accumulation of N-acetylglucosaminylasparagine (the linkage unit of asparagine-linked glycoproteins) in LYSOSOMES.	""	0	#FFFFFF
D054882	C05.116.099.370.894.115|C05.660.906.181|C16.131.621.906.181|C16.320.565.925.324|C18.452.648.925.324	Antley-Bixler Syndrome Phenotype	An inherited condition characterized by multiple malformations of CARTILAGE and bone including CRANIOSYNOSTOSIS; midface hypoplasia; radiohumeral SYNOSTOSIS; CHOANAL ATRESIA; femoral bowing; neonatal fractures; and multiple joint CONTRACTURES and, occasionally, urogenital, gastrointestinal or cardiac defects. In utero exposure to FLUCONAZOLE, as well as mutations in at least two separate genes are associated with this condition - POR (encoding P450 (cytochrome) oxidoreductase (NADPH-FERRIHEMOPROTEIN REDUCTASE)) and FGFR2 (encoding FIBROBLAST GROWTH FACTOR RECEPTOR 2).	""	0	#FFFFFF
D054908	C01.150.252.410.040.552.846.775.500	Extensively Drug-Resistant Tuberculosis	Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.	""	0	#FFFFFF
D054969	C10.177.575	Primary Dysautonomias	Disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a primary condition. Manifestations can involve any or all body systems but commonly affect the BLOOD PRESSURE and HEART RATE.	""	0	#FFFFFF
D054970	C10.177.575.650	Pure Autonomic Failure	A degenerative disease of the AUTONOMIC NERVOUS SYSTEM that is characterized by idiopathic ORTHOSTATIC HYPOTENSION and a greatly reduced level of CATECHOLAMINES. No other neurological deficits are present.	""	0	#FFFFFF
D054971	C10.177.575.600|C23.888.592.610	Orthostatic Intolerance	Symptoms of cerebral hypoperfusion or autonomic overaction which develop while the subject is standing, but are relieved on recumbency. Types of this include NEUROCARDIOGENIC SYNCOPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; and neurogenic ORTHOSTATIC HYPOTENSION. (From Noseworthy, JH., Neurological Therapeutics Principles and Practice, 2007, p2575-2576)	""	0	#FFFFFF
D054972	C10.177.575.600.625	Postural Orthostatic Tachycardia Syndrome	A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.	""	0	#FFFFFF
D054973	C04.557.450.692	Perivascular Epithelioid Cell Neoplasms	A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These cells do not have a normal anatomic homolog. (From Fletcher CDM, et. al., World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002).	""	0	#FFFFFF
D054975	C04.445.622|C04.588.614.250.195.885.500.299|C05.660.585.600.374|C10.228.140.211.885.500.299|C10.228.140.617.477.299|C10.551.240.250.700.500.249|C16.131.077.690|C16.131.621.585.600.374	Pallister-Hall Syndrome	A pleiotropic disorder of human development that comprises hypothalamic HAMARTOMA; central and postaxial POLYDACTYLY; bifid EPIGLOTTIS; ANAL ATRESIA; and renal and other abnormalities. This disorder is associated with FRAMESHIFT MUTATIONS in the GLI3 gene which encodes the GLI3 protein, a KRUPPEL-LIKE TRANSCRIPTION FACTORS family member.	""	0	#FFFFFF
D054988	C08.381.483.652.500.750	Idiopathic Interstitial Pneumonias	A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.	""	0	#FFFFFF
D054989	C17.800.553|C23.550.355.550	Nephrogenic Fibrosing Dermopathy	A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.	""	0	#FFFFFF
D054990	C08.381.483.652.500	Idiopathic Pulmonary Fibrosis	A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.	""	0	#FFFFFF
D055008	C08.381.483.581.062|C08.381.520.702.062	Anthracosis	A diffuse parenchymal lung disease caused by accumulation of inhaled CARBON or coal dust. The disease can progress from asymptomatic anthracosis to massive lung fibrosis. This lung lesion usually occurs in coal MINERS, but can be seen in urban dwellers and tobacco smokers.	""	0	#FFFFFF
D055009	C05.116.900.938	Spondylosis	A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.	""	0	#FFFFFF
D055010	C05.116.900.596	Posterior Cervical Sympathetic Syndrome	A pathological condition that is characterized by a host of cranial symptoms, such as headaches, abnormal functions of the eyes and the ears, and psychological and mental disorders. This syndrome usually appears after neck injuries, inflammation, or neoplasm.	""	0	#FFFFFF
D055013	C05.116.900.853.625.399|C05.550.114.606.750|C05.550.114.865.399|C05.799.613.750	Osteoarthritis, Spine	A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).	""	0	#FFFFFF
D055031	C14.907.725.675|C23.550.767.877.750	Primary Graft Dysfunction	A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.	""	0	#FFFFFF
D055034	C05.116.821	Osteochondrosis	Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).	""	0	#FFFFFF
D055035	C05.116.821.500|C05.116.900.808	Spinal Osteochondrosis	A bone disorder involving ossification centers (EPIPHYSES) of the VERTEBRAL COLUMN.	""	0	#FFFFFF
D055036	C05.660.142|C16.131.621.142	Campomelic Dysplasia	A congenital disorder of CHONDROGENESIS and OSTEOGENESIS characterized by hypoplasia of endochondral bones. In most cases there is a curvature of the long bones especially the TIBIA with dimpling of the skin over the bowed areas, malformation of the pelvis and spine, 11 pairs of ribs, hypoplastic scapulae, club feet, micrognathia, CLEFT PALATE, tracheobronchomalacia, and in some patients male-to-female sex reversal (SEX REVERSAL, GONADAL). Most patients die in the neonatal period of respiratory distress. Campomelic dysplasia is associated with haploinsufficiency of the SOX9 TRANSCRIPTION FACTOR gene.	""	0	#FFFFFF
D055089	C05.182.895|C08.127.719|C08.907.796|C16.131.621.953|C17.300.182.895	Tracheobronchomalacia	A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the TRACHEA and the BRONCHI. This results in a floppy non-rigid airway making patency difficult to maintain.	""	0	#FFFFFF
D055090	C05.182.895.500|C08.907.796.500|C16.131.621.953.500|C17.300.182.895.500	Tracheomalacia	A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the TRACHEA. This results in a floppy tracheal wall making patency difficult to maintain. It is characterized by wheezing and difficult breathing.	""	0	#FFFFFF
D055091	C05.182.895.249|C08.127.719.500|C16.131.621.953.249|C17.300.182.895.249	Bronchomalacia	A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the BRONCHI. This results in a floppy bronchial wall making patency difficult to maintain. It is characterized by wheezing and difficult breathing.	""	0	#FFFFFF
D055092	C05.182.310|C08.360.563|C09.400.563|C16.131.621.568|C17.300.182.310	Laryngomalacia	A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the LARYNX. This results in a floppy laryngeal wall making patency difficult to maintain.	""	0	#FFFFFF
D055093	C07.465.714.354	Periodontal Atrophy	Degradation or wasting of the PERIODONTIUM tissues that may involve the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, or the PERIODONTAL LIGAMENT.	""	0	#FFFFFF
D055111	C23.550.767.225|C23.888.592.612.107.200	Failed Back Surgery Syndrome	A condition of persistent pain and discomfort in the BACK and the LEG following lumbar surgery, often seen in patients enrolled in pain centers.	""	0	#FFFFFF
D055112	C12.050.351.500.852.544|C12.100.250.852.544	Pyometra	An accumulation of PUS in the uterine cavity (UTERUS). Pyometra generally indicates the presence of infections.	""	0	#FFFFFF
D055113	C07.465.714.533.324|C23.550.291.500.313	Chronic Periodontitis	Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.	""	0	#FFFFFF
D055154	C08.360.940.325|C09.400.940.325|C10.597.975.325|C23.888.592.979.325	Dysphonia	Difficulty and/or pain in PHONATION or speaking.	""	0	#FFFFFF
D055191	C23.550.767.137	Delayed Emergence from Anesthesia	Abnormally slow pace of regaining CONSCIOUSNESS after general anesthesia (ANESTHESIA, GENERAL) usually given during surgical procedures. This condition is characterized by persistent somnolence.	""	0	#FFFFFF
D055331	C04.557.435.108	Adenomyoepithelioma	A mixed epithelial and myoepithelial neoplasm usually encountered within the breast. It is a multinodular lesion presenting with a bicellular pattern of proliferating epithelial and myoepithelial cells, which are regularly distributed in the glandular structures.	""	0	#FFFFFF
D055370	C08.381.520|C26.891.554	Lung Injury	Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.	""	0	#FFFFFF
D055371	C08.381.520.500	Acute Lung Injury	A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	""	0	#FFFFFF
D055397	C08.381.520.750	Ventilator-Induced Lung Injury	Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.	""	0	#FFFFFF
D055496	C06.405.469.158.272.804	Neurogenic Bowel	Loss or absence of normal intestinal function due to nerve damage or birth defects. It is characterized by the inability to control the elimination of stool from the body.	""	0	#FFFFFF
D055499	C01.195	Catheter-Related Infections	Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.	""	0	#FFFFFF
D055501	C20.683.515.800	Macrophage Activation Syndrome	A serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T-LYMPHOCYTES and MACROPHAGES. It is seen predominantly in children with systemic onset JUVENILE IDIOPATHIC ARTHRITIS.	""	0	#FFFFFF
D055534	C10.228.854.468.399|C10.574.500.175|C10.574.562.500.374|C10.668.467.500.186|C16.320.322.076|C16.320.400.100	Bulbo-Spinal Atrophy, X-Linked	An X-linked recessive form of spinal muscular atrophy. It is due to a mutation of the gene encoding the ANDROGEN RECEPTOR.	""	0	#FFFFFF
D055535	C17.800.518	Morgellons Disease	An unexplained illness which is characterized by skin manifestations including non-healing lesions, itching, and the appearance of fibers.	""	0	#FFFFFF
D055538	C15.378.071.141.150.875.575|C15.378.420.826.200|C16.320.070.875.575|C16.320.365.826.575	delta-Thalassemia	A hereditary disorder characterized by reduced or absent DELTA-GLOBIN thus effecting the level of HEMOGLOBIN A2, a minor component of adult hemoglobin monitored in the diagnosis of BETA-THALASSEMIA.	""	0	#FFFFFF
D055577	C10.228.140.163.100.435.825.250|C16.320.565.189.435.825.250|C16.320.565.398.641.803.325|C16.320.565.595.554.825.250|C18.452.132.100.435.825.250|C18.452.584.563.641.803.325|C18.452.648.189.435.825.250|C18.452.648.398.641.803.325|C18.452.648.595.554.825.250	Farber Lipogranulomatosis	A sphingolipidosis subtype that is characterized by the histological appearance of granulomatous deposits in tissues. It results from the accumulation of CERAMIDES in various tissues due to an inherited deficiency of ACID CERAMIDASE.	""	0	#FFFFFF
D055589	C06.689.750.860	Pancreatitis, Graft	An inflammatory disease and serious complication of PANCREAS TRANSPLANTATION. It is caused by a premature activation of pancreatic proenzymes leading to autodigestion of the gland and can be attributed to immunological or nonimmunological causes.	""	0	#FFFFFF
D055613	C04.588.894.797.520.237|C08.381.540.148|C08.785.520.148	Multiple Pulmonary Nodules	A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.	""	0	#FFFFFF
D055622	C05.651.594.728|C10.668.491.562.537|C11.675.426	Orbital Myositis	Inflammation of the extraocular muscle of the eye. It is characterized by swelling which can lead to ischemia, fibrosis, or ORBITAL PSEUDOTUMOR.	""	0	#FFFFFF
D055623	C04.834.450|C17.800.428.570	Keratosis, Actinic	White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.	""	0	#FFFFFF
D055652	C15.378.140.427|C16.320.099.417	Gray Platelet Syndrome	A rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time.	""	0	#FFFFFF
D055653	C04.588.805.578.500|C04.700.250.500.500|C16.320.700.250.500.500|C17.800.794.712.500|C17.800.827.610|C17.800.882.712.500	Muir-Torre Syndrome	A form of LYNCH SYNDROME II associated with cutaneous SEBACEOUS GLAND NEOPLASMS. Muir-Torre syndrome is also associated with other visceral malignant diseases include colorectal, endometrial, urological, and upper gastrointestinal neoplasms.	""	0	#FFFFFF
D055665	C15.378.100.802.230|C23.550.414.950.230|C23.888.885.687.230	Purpura Fulminans	A severe, rapidly fatal reaction occurring most commonly in children following an infectious illness. It is characterized by large, rapidly spreading skin hemorrhages, fever, or shock. Purpura fulminans often accompanies or is triggered by DISSEMINATED INTRAVASCULAR COAGULATION.	""	0	#FFFFFF
D055673	C10.500.034.500|C16.131.666.034.500	Acrocallosal Syndrome	Autosomal recessive syndrome characterized by hypogenesis or agenesis of CORPUS CALLOSUM. Clinical features include MENTAL RETARDATION; CRANIOFACIAL ABNORMALITIES; digital malformations, and growth retardation.	""	0	#FFFFFF
D055677	C18.654.521.687	Refeeding Syndrome	A condition of metabolic imbalance that is caused by complications of initially feeding a severely malnourished patient too aggressively. Usually occurring within the first 5 days of refeeding, this syndrome is characterized by WATER-ELECTROLYTE IMBALANCE; GLUCOSE INTOLERANCE; CARDIAC ARRHYTHMIAS; and DIARRHEA.	""	0	#FFFFFF
D055728	C15.378.190.636.765	Primary Myelofibrosis	A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.	""	0	#FFFFFF
D055732	C01.150.703.080.768|C01.150.703.534.850|C08.381.472.850	Pulmonary Aspergillosis	Infections of the respiratory tract with fungi of the genus ASPERGILLUS.	""	0	#FFFFFF
D055744	C01.150.703.080.768.750|C01.150.703.492.688|C01.150.703.534.850.750|C08.381.472.850.750	Invasive Pulmonary Aspergillosis	Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.	""	0	#FFFFFF
D055752	C04.588.894.797.520.109.220.624|C08.381.540.140.750|C08.785.520.100.220.750	Small Cell Lung Carcinoma	A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).	""	0	#FFFFFF
D055756	C04.588.614.250.580.150|C10.551.240.500.150	Meningeal Carcinomatosis	Primary or secondary neoplasm in the ARACHNOID or SUBARACHNOID SPACE. It appears as a diffuse fibrotic thickening of the MENINGES associated with variable degrees of inflammation.	""	0	#FFFFFF
D055761	C01.925.744|C22.131.780	Reticuloendotheliosis, Avian	A group of pathologic syndromes found in avian species caused by RETICULOENDOTHELIOSIS VIRUS. The distinct syndromes include non-neoplastic runting, acute neoplastic disease, and chronic neoplastic disease. Humans and mammals appear resistant.	""	0	#FFFFFF
D055847	C04.700.250.500|C16.320.700.250.500	Lynch Syndrome II	Hereditary nonpolyposis colorectal neoplasms associated with other malignancies, more commonly of ovarian or uterine origin. When also associated with SEBACEOUS GLAND NEOPLASMS, it is called MUIR-TORRE SYNDROME.	""	0	#FFFFFF
D055882	C04.557.665.560.580	Nevus, Halo	A benign skin lesion characterized by a zone of depigmentation surrounding the nevus.	""	0	#FFFFFF
D055947	C05.660.207.532|C14.907.055.050.362|C14.907.055.239.587|C14.907.109.139.587|C16.131.077.537|C16.320.510	Loeys-Dietz Syndrome	An autosomal dominant aneurysm with multisystem abnormalities caused by increased TGF-BETA signaling due to mutations in type I or II of TGF-BETA RECEPTOR. Additional craniofacial features include CLEFT PALATE; CRANIOSYNOSTOSIS; HYPERTELORISM; or bifid uvula. Phenotypes closely resemble MARFAN SYNDROME; Marfanoid craniosynostosis syndrome (Shprintzen-Goldberg syndrome); and EHLERS-DANLOS SYNDROME.	""	0	#FFFFFF
D055948	C10.597.613.612.500|C23.300.070.500.500|C23.888.592.608.612.500	Sarcopenia	Progressive decline in muscle mass due to aging which results in decreased functional capacity of muscles.	""	0	#FFFFFF
D055949	C12.050.703.420.952	Vasa Previa	Pregnancy complication where fetal blood vessels, normally inside the umbilical cord, are left unprotected and cross FETAL MEMBRANES. It is associated with antepartum bleeding and FETAL DEATH and STILLBIRTH due to exsanguination.	""	0	#FFFFFF
D055952	C10.292.910.299|C11.180|C14.907.940.320	Cogan Syndrome	A condition consisting of inflammatory eye disease usually presenting as interstitial KERATITIS, vestibuloauditory dysfunction, and large- to medium-vessel vasculitis.	""	0	#FFFFFF
D055953	C10.228.140.300.275.600|C14.907.253.329.600|C14.907.940.897.249.500|C20.111.193.750	Microscopic Polyangiitis	A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.	""	0	#FFFFFF
D055954	C11.204.278|C11.300.250|C23.550.767.093|C23.888.307.250	Corneal Endothelial Cell Loss	Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.	""	0	#FFFFFF
D055955	C09.218.855|C10.228.140.300.787|C10.597.825|C11.768.400.500|C11.966.858|C14.907.137.780.500|C23.888.307.750|C23.888.592.848	Susac Syndrome	A rare disorder consisting of microangiopathy of brain, retina, and inner ear ARTERIOLES. It is characterized by the clinical triad of encephalopathy, BRANCH RETINAL ARTERY OCCLUSION and VERTIGO/hearing loss.	""	0	#FFFFFF
D055956	C10.228.140.380.254|C10.574.945.374	Diffuse Neurofibrillary Tangles with Calcification	A form of presenile DEMENTIA characterized by cortical dementia, NEUROFIBRILLARY TANGLES without SENILE PLAQUES, Fahr's type CALCINOSIS, and ATROPHY in frontotemporal or TEMPORAL LOBE.	""	0	#FFFFFF
D055958	C10.668.829.500.675.399|C10.668.829.550.500|C10.668.829.600.675|C23.888.592.612.664.675|C23.888.592.612.944.750	Piriformis Muscle Syndrome	A chronic PELVIC PAIN characterized by pain deep in the buttock that may radiate to posterior aspects of the leg. It is caused by the piriformis muscle compressing or irritating the SCIATIC NERVE due to trauma, hypertrophy, inflammation or anatomic variations.	""	0	#FFFFFF
D055959	C05.116.900.153	Intervertebral Disc Degeneration	Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.	""	0	#FFFFFF
D055963	C08.127.108.054|C08.674.095.054|C20.543.206.189|C20.543.480.149|C25.100.468.189	Asthma, Aspirin-Induced	Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.	""	0	#FFFFFF
D055964	C10.597.606.881.350.099|C23.888.592.604.882.350.099	Alien Hand Syndrome	An apraxia characterized by the affected limb having involuntary, autonomous, and purposeful behaviors that are perceived as being controlled by an external force. Often the affected limb interferes with the actions of the normal limb. Symptoms develop from lesions in the CORPUS CALLOSUM or medial frontal cortex, stroke, infarction, and neurodegenerative diseases (e.g., CREUTZFELDT-JAKOB SYNDROME, corticobasal degeneration).	""	0	#FFFFFF
D055985	C01.150.252.410.040.552.846.122|C01.550.500	Latent Tuberculosis	The dormant form of TUBERCULOSIS where the person shows no obvious symptoms and no sign of the causative agent (Mycobacterium tuberculosis) in the SPUTUM despite being positive for tuberculosis infection skin test.	""	0	#FFFFFF
D056005	C01.150.252.410.040.552.475.371.850	Leprosy, Paucibacillary	A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with paucibacillary leprosy have fewer than six skin lesions with no causative agent MYCOBACTERIUM LEPRAE on any slit-skin smear testing. Paucibacillary leprosy encompasses indeterminate, borderline tuberculoid, and tuberculoid leprosy.	""	0	#FFFFFF
D056006	C01.150.252.410.040.552.475.371.775	Leprosy, Multibacillary	A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with multibacillary leprosy have six or more lesions with or without positive skin smear results for the causative agent MYCOBACTERIUM LEPRAE. Multibacillary leprosy encompasses borderline lepromatous, midborderline, and lepromatous leprosy.	""	0	#FFFFFF
D056104	C14.280.067.441|C26.891.375.750.500|C26.974.250.875.500	Commotio Cordis	A sudden CARDIAC ARRHYTHMIA (e.g., VENTRICULAR FIBRILLATION) caused by a blunt, non-penetrating impact to the precordial region of chest wall. Commotio cordis often results in sudden death without prompt cardiopulmonary defibrillation.	""	0	#FFFFFF
D056124	C23.550.767.884|C23.888.592.612.441.500	Slit Ventricle Syndrome	An intermittent and self-limiting headache disorder in individuals with CEREBROSPINAL FLUID SHUNTS emplaced for the treatment of HYDROCEPHALUS. The symptoms of headache, vomiting, and cranial neuropathies are associated with intermittent obstruction of the shunt.	""	0	#FFFFFF
D056128	C18.654.726.750.500.615|C23.888.144.699.500.063	Obesity, Abdominal	A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as DIABETES; HYPERTENSION; and METABOLIC SYNDROME.	""	0	#FFFFFF
D056146	C23.550.260.224.200|C26.986.111	Corpse Dismemberment	Disjoining the limbs or other parts of a corpse, often in association with criminal acts.	""	0	#FFFFFF
D056150	C17.800.174.600.174|C20.543.206.380.174|C25.100.468.380.174	Acute Generalized Exanthematous Pustulosis	Rare skin eruption characterized by acute formation of pustules filled with NEUTROPHILS, fever, and peripheral blood LEUKOCYTOSIS. Most cases are associated with the use of antibiotics (e.g., BETA-LACTAMS).	""	0	#FFFFFF
D056151	C23.300.017	Airway Remodeling	The structural changes in the number, mass, size and/or composition of the airway tissues.	""	0	#FFFFFF
D056266	C16.320.850.337|C17.800.229.606|C17.800.428.304|C17.800.827.337	Erythrokeratodermia Variabilis	An autosomal dominant skin disease characterized by transient and variable noninflammatory ERYTHEMA and hyperkeratosis. It has been associated with mutations in the genes that code for CONNEXINS. Erythrokeratodermia variabilis inherited in an autosomal recessive fashion has also been reported. Affected individuals often develop PALMOPLANTAR KERATODERMA.	""	0	#FFFFFF
D056267	C04.557.386.480.750.800.550.600|C15.604.515.569.480.750.800.550.600|C20.683.515.761.480.750.800.550.600	Pagetoid Reticulosis	A distinct variant of mycosis fungoides characterized by the presence of localized patches or plaques with an intraepidermal proliferation of neoplastic cells.	""	0	#FFFFFF
D056304	C05.116.482	Genu Valgum	An inward slant of the thigh in which the knees are close together and the ankles far apart. Genu valgum can develop due to skeletal and joint dysplasias (e.g., OSTEOARTHRITIS; HURLER SYNDROME); and malnutrition (e.g., RICKETS; FLUORIDE POISONING).	""	0	#FFFFFF
D056305	C05.116.511	Genu Varum	An outward slant of the thigh in which the knees are wide apart and the ankles close together. Genu varum can develop due to skeletal and joint dysplasia (e.g., OSTEOARTHRITIS; Blount's disease); and malnutrition (e.g., RICKETS; FLUORIDE POISONING).	""	0	#FFFFFF
D056364	C04.182.199|C04.588.614.250.387.200|C10.500.142.200|C10.551.240.375.200|C16.131.666.142.200	Colloid Cysts	Benign, congenital, neuroepithelial cysts that are typically filled with a viscous mucus. They usually arise in the anterior portion of the THIRD VENTRICLE between the fornices.	""	0	#FFFFFF
D056486	C06.552.100|C25.100.562|C25.723.260	Chemical and Drug Induced Liver Injury	A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	""	0	#FFFFFF
D056487	C06.552.100.200|C23.550.291.500.266|C25.100.562.200|C25.723.260.200	Chemical and Drug Induced Liver Injury, Chronic	Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.	""	0	#FFFFFF
D056586	C08.381.074|C08.618.009|C15.378.071.141.150.150.219|C15.378.420.155.219|C16.320.070.150.219|C16.320.365.155.219	Acute Chest Syndrome	Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.	""	0	#FFFFFF
D056587	C16.320.382.500|C17.800.827.368.500	Cryopyrin-Associated Periodic Syndromes	A group of rare autosomal dominant diseases, commonly characterized by atypical URTICARIA (hives) with systemic symptoms that develop into end-organ damage. The atypical hives do not involve T-cell or autoantibody. Cryopyrin-associated periodic syndrome includes three previously distinct disorders: Familial cold autoinflammatory syndrome; Muckle-Wells Syndrome; and CINCA Syndrome, that are now considered to represent a disease continuum, all caused by NLRP3 PROTEIN mutations.	""	0	#FFFFFF
D056627	C06.844.610|C23.550.355.625	Peritoneal Fibrosis	Disorder characterized by a wide range of structural changes in PERITONEUM, resulting from fibrogenic or inflammatory processes. Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency.	""	0	#FFFFFF
D056647	C14.907.940.897	Systemic Vasculitis	A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.	""	0	#FFFFFF
D056648	C14.907.940.897.249|C20.111.193	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.	""	0	#FFFFFF
D056650	C12.050.351.500.944.951|C12.100.250.944.951	Vulvodynia	Complex pain syndrome with unknown etiology, characterized by constant or intermittent generalized vulva pain (Generalized vulvodynia) or localized burning sensations in the VESTIBULE area when pressure is applied (Vestibulodynia, or Vulvar Vestibulitis Syndrome). Typically, vulvar tissue with vulvodynia appears normal without infection or skin disease. Vulvodynia impacts negatively on a woman's quality of life as it interferes with sexual and daily activities.	""	0	#FFFFFF
D056653	C05.550.114.154.728|C05.799.114.728|C14.907.940.897.750|C17.300.775.099.728|C20.111.199.581	Rheumatoid Vasculitis	Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ULCERS, peripheral GANGRENE, and MONONEURITIS MULTIPLEX.	""	0	#FFFFFF
D056660	C16.320.382|C17.800.827.368	Hereditary Autoinflammatory Diseases	Hereditary inflammation conditions, characterized by recurrent episodes of systemic inflammation. Common symptoms include recurrent fever, rash, arthritis, fatigue, and secondary AMYLOIDOSIS. Hereditary autoinflammatory diseases are associated with mutations in genes involved in regulation of normal inflammatory process and are not caused by AUTOANTIBODIES, or antigen specific T-LYMPHOCYTES.	""	0	#FFFFFF
D056684	C16.320.962|C17.800.529.819|C17.800.621.968|C23.300.820.500	Yellow Nail Syndrome	A rare condition characterized by the presence of yellow nails, LYMPHEDEMA, and/or PLEURAL EFFUSION with respiratory tract involvement. Abnormal lymphatic network may play a role in its etiology. Occasionally inherited, yellow nail syndrome mostly is sporadic without apparent family history.	""	0	#FFFFFF
D056685	C05.660.207.219|C16.131.077.256|C16.320.188	Costello Syndrome	Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).	""	0	#FFFFFF
D056693	C16.320.565.100.823|C18.452.648.100.823	Propionic Acidemia	Autosomal recessive metabolic disorder caused by mutations in PROPIONYL-COA CARBOXYLASE genes that result in dysfunction of branch chain amino acids and of the metabolism of certain fatty acids. Neonatal clinical onset is characterized by severe metabolic acidemia accompanied by hyperammonemia, HYPERGLYCEMIA, lethargy, vomiting, HYPOTONIA; and HEPATOMEGALY. Survivors of the neonatal onset propionic acidemia often show developmental retardation, and intolerance to dietary proteins. Late-onset form of the disease shows mild mental and/or developmental retardation, sometimes without metabolic acidemia.	""	0	#FFFFFF
D056725	C15.378.100.100.900.100|C15.378.100.141.900.100|C15.378.463.920.100|C16.320.099.920.100	von Willebrand Disease, Type 1	A subtype of von Willebrand disease that results from a partial deficiency of VON WILLEBRAND FACTOR.	""	0	#FFFFFF
D056728	C15.378.100.100.900.200|C15.378.100.141.900.200|C15.378.463.920.200|C16.320.099.920.200	von Willebrand Disease, Type 2	A subtype of von Willebrand disease that results from qualitative deficiencies of VON WILLEBRAND FACTOR. The subtype is divided into several variants with each variant having a distinctive pattern of PLATELET-interaction.	""	0	#FFFFFF
D056729	C15.378.100.100.900.300|C15.378.100.141.900.300|C15.378.463.920.300|C16.320.099.920.300	von Willebrand Disease, Type 3	A subtype of von Willebrand disease that results from a total or near total deficiency of VON WILLEBRAND FACTOR.	""	0	#FFFFFF
D056730	C05.660.207.925|C16.131.077.855|C16.131.260.870|C16.320.180.870|C16.320.240.937	Silver-Russell Syndrome	Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly of the fifth fingers. Alterations in GENETIC IMPRINTING are involved. Hypomethylation of IGF2/H19 locus near an imprinting center region of chromosome 11p15 plays a role in a subset of Silver-Russell syndrome. Hypermethylation of the same chromosomal region, on the other hand, can cause BECKWITH-WIEDEMANN SYNDROME. Maternal UNIPARENTAL DISOMY for chromosome 7 is known to play a role in its etiology.	""	0	#FFFFFF
D056731	C05.660.207.325|C16.131.077.313|C16.320.215|C18.452.394.750.654|C19.246.537	Donohue Syndrome	Rare autosomal recessive syndrome of extreme insulin resistance due to mutations in the binding domain of INSULIN RECEPTOR. Clinical features include severe intrauterine and postnatal growth restriction, characteristic dysmorphic FACIES; HIRSUTISM; VIRILIZATION; multiple endocrine abnormalities, and early death.	""	0	#FFFFFF
D056732	C16.131.077.735|C16.131.831.720|C16.320.565.100.794|C16.320.850.746	Prolidase Deficiency	Rare autosomal recessive disorder of metabolism due to mutations in the prolidase gene. It is characterized by recurrent lower extremity skin ulcers, recurrent infections, and FACIES, often with INTELLECTUAL DISABILITY.	""	0	#FFFFFF
D056733	C04.557.450.565.550.312|C04.588.894.309.500|C14.280.459.500|C16.131.077.229|C16.131.831.108	Carney Complex	Autosomal dominant syndrome characterized by cardiac and cutaneous MYXOMAS; LENTIGINOSIS (spotty pigmentation of the skin), and endocrinopathy and its associated endocrine tumors. The cardiac myxomas may lead to SUDDEN CARDIAC DEATH and other complications in Carney complex patients. The gene coding for the PRKAR1A protein is one of the causative genetic loci (type 1). A second locus is at chromosome 2p16 (type 2).	""	0	#FFFFFF
D056734	C16.131.077.592|C16.320.850.647|C17.800.329.984|C17.800.827.602	Monilethrix	Rare autosomal dominant disorder of the hair shaft. The clinical features of the disease include HYPOTRICHOSIS, dry, and/or brittle hair, with varying degrees of ALOPECIA. Mutations in the hair-specific keratin genes KRTHB1, KRTHB3, or KRTHB6 are associated with monilethrix. Autosomal recessive monilethrix with limited HYPOTRICHOSIS are also known. Mutations in Dsg4, Liph, and P2ry5 protein genes are associated with the recessive form of monilethrix.	""	0	#FFFFFF
D056735	C15.604.515.138|C16.320.089|C20.111.288|C20.683.515.124	Autoimmune Lymphoproliferative Syndrome	Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.	""	0	#FFFFFF
D056768	C10.500.300.490|C10.574.500.495.490|C10.668.829.325|C10.668.829.800.300.490|C16.131.666.300.490|C16.320.400.375.490	Giant Axonal Neuropathy	Rare autosomal recessive disorder of INTERMEDIATE FILAMENT PROTEINS. The disease is caused by mutations in the gene that codes gigaxonin protein. The mutations result in disorganization of axonal NEUROFILAMENT PROTEINS, formation of the characteristic giant axons, and progressive neuropathy. The clinical features of the disease include early-onset progressive peripheral motor and sensory neuropathies often associated with central nervous system involvement (INTELLECTUAL DISABILITY, seizures, DYSMETRIA, and CONGENITAL NYSTAGMUS).	""	0	#FFFFFF
D056769	C10.500.300.099|C10.574.500.495.099|C10.668.829.800.300.099|C11.270.684.249|C16.131.077.245.063|C16.131.666.300.099|C16.320.184.063|C16.320.290.684.249|C16.320.400.375.099	Alstrom Syndrome	Rare autosomal recessive disease characterized by multiple organ dysfunction. The key clinical features include retinal degeneration (NYSTAGMUS, PATHOLOGIC; RETINITIS PIGMENTOSA; and eventual blindness), childhood obesity, sensorineural hearing loss, and normal mental development. Endocrinologic complications include TYPE 2 DIABETES MELLITUS; HYPERINSULINEMIA; ACANTHOSIS NIGRICANS; HYPOTHYROIDISM; and progressive renal and hepatic failures. The disease is caused by mutations in the ALMS1 gene.	""	0	#FFFFFF
D056770	C16.131.077.619|C16.131.831.512.400.705|C16.320.850.673|C16.614.492.400.705|C17.800.428.333.250.705|C17.800.804.512.400.705|C17.800.827.655	Netherton Syndrome	Rare autosomal recessive disease with variable expressions. Clinical features of the disease include variable ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL; bamboo hair (trichorrhexis invaginata); and ATOPIC DERMATITIS. The disease is caused by mutations in the SPINK5 gene.	""	0	#FFFFFF
D056784	C10.228.140.695	Leukoencephalopathies	Any of various diseases affecting the white matter of the central nervous system.	""	0	#FFFFFF
D056806	C10.228.140.163.100.937|C16.320.565.100.940|C16.320.565.189.937|C18.452.132.100.937|C18.452.648.100.940|C18.452.648.189.937	Urea Cycle Disorders, Inborn	Rare congenital metabolism disorders of the urea cycle. The disorders are due to mutations that result in complete (neonatal onset) or partial (childhood or adult onset) inactivity of an enzyme, involved in the urea cycle. Neonatal onset results in clinical features that include irritability, vomiting, lethargy, seizures, NEONATAL HYPOTONIA; RESPIRATORY ALKALOSIS; HYPERAMMONEMIA; coma, and death. Survivors of the neonatal onset and childhood/adult onset disorders share common risks for ENCEPHALOPATHIES, METABOLIC, INBORN; and RESPIRATORY ALKALOSIS due to HYPERAMMONEMIA.	""	0	#FFFFFF
D056807	C10.228.140.163.100.937.124|C16.320.565.100.940.124|C16.320.565.189.937.124|C18.452.132.100.937.124|C18.452.648.100.940.124|C18.452.648.189.937.124	Argininosuccinic Aciduria	Rare autosomal recessive disorder of the urea cycle which leads to the accumulation of argininosuccinic acid in body fluids and severe HYPERAMMONEMIA. Clinical features of the neonatal onset of the disorder include poor feeding, vomiting, lethargy, seizures, tachypnea, coma, and death. Later onset results in milder set of clinical features including vomiting, failure to thrive, irritability, behavioral problems, or psychomotor retardation. Mutations in the ARGININOSUCCINATE LYASE gene cause the disorder.	""	0	#FFFFFF
D056824	C14.907.355.830.925.885	Upper Extremity Deep Vein Thrombosis	DEEP VEIN THROMBOSIS of an upper extremity vein (e.g., AXILLARY VEIN; SUBCLAVIAN VEIN; and JUGULAR VEINS). It is associated with mechanical factors (Upper Extremity Deep Vein Thrombosis, Primary) secondary to other anatomic factors (Upper Extremity Deep Vein Thrombosis, Secondary). Symptoms may include sudden onset of pain, warmth, redness, blueness, and swelling in the arm.	""	0	#FFFFFF
D056828	C14.907.079.500.500|C17.800.862.945.066.500.500|C20.543.480.904.066.500.500	Hereditary Angioedema Type III	A form of hereditary angioedema that occurs in women and is precipitated or worsened by high ESTROGEN levels. It is associated with mutations in the gene for FACTOR XII that result in its increased activity.	""	0	#FFFFFF
D056829	C14.907.079.500.750|C17.800.862.945.066.500.750|C20.543.480.904.066.500.750	Hereditary Angioedema Types I and II	Forms of hereditary angioedema that occur due to mutations in the gene for COMPLEMENT C1 INHIBITOR PROTEIN. Type I hereditary angioedema is associated with reduced serum levels of complement C1 inhibitor protein. Type II hereditary angioedema is associated with the production of a non-functional complement C1 inhibitor protein.	""	0	#FFFFFF
D056830	C14.240.400.660|C14.280.238.281.500|C14.280.400.660|C16.131.077.477|C16.131.240.400.655|C16.320.322.370	Isolated Noncompaction of the Ventricular Myocardium	Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. Heterogeneous clinical features include diminished systolic function sometimes associated with left ventricular dilation, that presents either neonatally or progressively. Often, the RIGHT VENTRICLE is also affected. CONGESTIVE HEART FAILURE; PULMONARY EMBOLISM; and ventricular ARRHYTHMIA are commonly seen.	""	0	#FFFFFF
D056833	C11.768.175	Central Serous Chorioretinopathy	A visual impairment characterized by the accumulation of fluid under the retina through a defect in the retinal pigment epithelium.	""	0	#FFFFFF
D056844	C23.888.592.612.972|C23.888.721	Renal Colic	A severe intermittent and spasmodic pain in the lower back radiating to the groin, scrotum, and labia which is most commonly caused by a kidney stone (RENAL CALCULUS) passing through the URETER or by other urinary track blockage. It is often associated with nausea, vomiting, fever, restlessness, dull pain, frequent urination, and HEMATURIA.	""	0	#FFFFFF
D056846	C05.116.099.343.957|C11.270.921|C16.131.077.941|C16.320.290.842|C17.300.899	Weill-Marchesani Syndrome	Rare congenital disorder of connective tissue characterized by brachydactyly, joint stiffness, childhood onset of ocular abnormalities (e.g., microspherophakia, ECTOPIA LENTIS; GLAUCOMA), and proportionate short stature. Cardiovascular anomalies are occasionally seen.	""	0	#FFFFFF
D056886	C10.900.300.350.300.250|C26.224|C26.915.300.450.500.250|C26.974.382.200.250	Contrecoup Injury	An injury in which the damage is located on the opposite side of the primary impact site. A blow to the back of head which results in contrecoup injury to the frontal lobes of the brain is the most common type.	""	0	#FFFFFF
D056887	C23.300.842.624	Pelvic Organ Prolapse	Abnormal descent of a pelvic organ resulting in the protrusion of the organ beyond its normal anatomical confines. Symptoms often include vaginal discomfort, DYSPAREUNIA; URINARY STRESS INCONTINENCE; and FECAL INCONTINENCE.	""	0	#FFFFFF
D056889	C14.240.400.172|C14.280.400.172|C16.131.077.121|C16.131.240.400.172|C16.320.322.068|C16.320.565.398.224|C18.452.584.563.224|C18.452.648.398.224	Barth Syndrome	Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.	""	0	#FFFFFF
D056929	C12.050.351.968.419.815.683|C12.200.777.419.815.683|C12.950.419.815.683|C16.320.831.698	Liddle Syndrome	Familial pseudoaldosteronism characterized by autosomal dominant inheritance of hypertension with HYPOKALEMIA; ALKALOSIS; RENIN and ALDOSTERONE level decreases. It is caused by mutations in EPITHELIAL SODIUM CHANNELS beta and gamma subunits. Different mutations in the same EPITHELIAL SODIUM CHANNELS subunits can cause PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL DOMINANT.	""	0	#FFFFFF
D056986	C01.610.752.300	Euglenozoa Infections	Infections with the protozoa of the phylum EUGLENOZOA.	""	0	#FFFFFF
D056987	C14.907.946|C23.550.767.962	Vasoplegia	Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.	""	0	#FFFFFF
D056988	C14.280.647.500.093|C14.907.585.500.093|C23.550.513.355.750.093|C23.550.717.489.750.093	Anterior Wall Myocardial Infarction	MYOCARDIAL INFARCTION in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction.	""	0	#FFFFFF
D056989	C14.280.647.500.187|C14.907.585.500.187|C23.550.513.355.750.187|C23.550.717.489.750.187	Inferior Wall Myocardial Infarction	MYOCARDIAL INFARCTION in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery.	""	0	#FFFFFF
D057045	C06.405.117.119.500.484.500|C08.360.577	Laryngopharyngeal Reflux	Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX.	""	0	#FFFFFF
D057049	C15.378.140.855.925	Thrombotic Microangiopathies	Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.	""	0	#FFFFFF
D057066	C11.525.381.703|C11.640.225	Low Tension Glaucoma	A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure.	""	0	#FFFFFF
D057068	C26.404.550	Periprosthetic Fractures	Fractures around joint replacement prosthetics or implants. They can occur intraoperatively or postoperatively.	""	0	#FFFFFF
D057072	C26.404.505	Intra-Articular Fractures	Fractures of the articular surface of a bone.	""	0	#FFFFFF
D057085	C07.793.818	Tooth Wear	Loss of the tooth substance by chemical or mechanical processes	""	0	#FFFFFF
D057088	C17.300.116|C17.800.804.108	Anetoderma	Benign DERMATOSIS caused by a loss of dermal ELASTIC TISSUE resulting in localized sac-like areas of flaccid skin. It can be either primary (idiopathic) or secondary to other skin conditions, PENICILLAMINE use, or premature birth.	""	0	#FFFFFF
D057090	C04.557.470.200.025.500	Eccrine Porocarcinoma	A rare malignant neoplasm of the sweat glands. It most often develops as a form of degenerative progression from a benign ECCRINE POROMA.	""	0	#FFFFFF
D057091	C04.557.470.035.175.588|C04.557.470.550.175.588	Poroma	A benign adnexal neoplasm derived from cells of the terminal duct of eccrine or apocrine SWEAT GLAND lineage. They typically manifest as solitary papules and occur only in the skin but unlike in ACROSPIROMA involves the epidermis.	""	0	#FFFFFF
D057092	C11.768.585.439.122	Geographic Atrophy	A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.	""	0	#FFFFFF
D057096	C25.723.415.792	Shellfish Poisoning	Poisoning from toxins present in bivalve mollusks that have been ingested. Four distinct types of shellfish poisoning are recognized based on the toxin involved.	""	0	#FFFFFF
D057108	C11.204.431|C11.744.345	Corneal Wavefront Aberration	Asymmetries in the topography and refractive index of the corneal surface that affect visual acuity.	""	0	#FFFFFF
D057112	C10.900.300.284.250.124.500|C11.204.284.500|C11.297.374.500|C26.915.300.425.250.124.500	Corneal Perforation	A puncture or hole through the CORNEAL STROMA resulting from various diseases or trauma.	""	0	#FFFFFF
D057129	C11.204.497|C11.941.375.322	Iridocorneal Endothelial Syndrome	A grouping of three closely linked conditions: iris nevus (or Cogan-Reese) syndrome, Chandler Syndrome, and essential (progressive) iris atrophy. The most common features of this syndrome are the movement of endothelial cells off the cornea onto the iris leading to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil. The abnormal cell movement plugs fluid outflow channels of the eye causing GLAUCOMA.	""	0	#FFFFFF
D057130	C11.270.516|C11.768.364	Leber Congenital Amaurosis	A rare degenerative inherited eye disease that appears at birth or in the first few months of life that results in a loss of vision. Not to be confused with LEBER HEREDITARY OPTIC NEUROPATHY, the disease is thought to be caused by abnormal development of PHOTORECEPTOR CELLS in the RETINA, or by the extremely premature degeneration of retinal cells.	""	0	#FFFFFF
D057135	C11.768.585.439.622	Wet Macular Degeneration	A form of RETINAL DEGENERATION in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision.	""	0	#FFFFFF
D057165	C18.452.845	Proteostasis Deficiencies	Disorders caused by imbalances in the PROTEIN HOMEOSTASIS network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.	""	0	#FFFFFF
D057174	C10.228.140.380.266|C10.574.950.300|C18.452.845.800.300	Frontotemporal Lobar Degeneration	Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.	""	0	#FFFFFF
D057177	C10.574.950|C18.452.845.800	TDP-43 Proteinopathies	Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.	""	0	#FFFFFF
D057178	C10.228.140.380.132.600|C10.228.140.380.266.600|C10.574.950.300.600|C10.597.606.150.500.800.100.155.600|C18.452.845.800.300.600|C23.888.592.604.150.500.800.100.155.600	Primary Progressive Nonfluent Aphasia	A form of frontotemporal lobar degeneration and a progressive form of dementia characterized by motor speech impairment and AGRAMMATISM, with relative sparing of single word comprehension and semantic memory.	""	0	#FFFFFF
D057180	C10.228.140.380.266.299|C10.574.950.300.299|C18.452.845.800.300.299	Frontotemporal Dementia	The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.	""	0	#FFFFFF
D057667	C26.324.436	Conducted Energy Weapon Injuries	The injuries caused by conducted energy weapons such as stun guns, shock batons, and cattle prods.	""	0	#FFFFFF
D057765	C06.405.117.620.209|C06.405.205.663.209|C15.378.553.231.341|C20.543.480.356	Eosinophilic Esophagitis	Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.	""	0	#FFFFFF
D057767	C05.116.099.708.534	Kashin-Beck Disease	Disabling osteochondrodysplasia with OSTEOSCLEROSIS, cone-shaped METAPHYSIS, and shortening of the DIAPHYSIS. It is endemic in parts of Siberia and northern China. Mineral deficiencies (e.g., selenium, iodine), fungal cereal contamination, and water contamination may be contributing factors in its etiology.	""	0	#FFFFFF
D057768	C08.618.846.600|C23.888.248.500|C23.888.852.700	Brief, Resolved, Unexplained Event	An event experienced by an infant or a child that is characterized by some combination of apnea, color change, change in muscle tone, choking, and gagging.	""	0	#FFFFFF
D057770	C16.320.850.368|C17.800.827.384	Hyalinosis, Systemic	Autosomal recessive disorder characterized by HYALINE deposition in the skin, bone, gastrointestinal tract, muscles and glands; multiple subcutaneous skin nodules; GINGIVAL HYPERTROPHY; and joint CONTRACTURES. Mutations in the capillary morphogenesis protein-2 are associated with the disorder.	""	0	#FFFFFF
D057772	C14.907.937|C26.940	Vascular System Injuries	Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.	""	0	#FFFFFF
D057774	C10.177.575.600.537|C14.907.514.611	Post-Exercise Hypotension	Transient reduction in blood pressure levels immediately after exercises that lasts 2-12 hours. The reduction varies but is typically 5-20 mm Hg when compared to pre-exercise levels. It exists both in normotensive and hypertensive individuals and may play a role in excercise related PHYSIOLOGIC ADAPTATION.	""	0	#FFFFFF
D057792	C06.130.120.135.812	Mirizzi Syndrome	Complication of CHOLELITHIASIS characterized by OBSTRUCTIVE JAUNDICE; abdominal pain, and fever.	""	0	#FFFFFF
D057826	C11.768.585.439.433|C16.320.290.763	Vitelliform Macular Dystrophy	Autosomal dominant hereditary maculopathy with childhood-onset accumulation of LIPOFUSION in RETINAL PIGMENT EPITHELIUM. Affected individuals develop progressive central acuity loss, and distorted vision (METAMORPHOPSIA). It is associated with mutations in bestrophin, a chloride channel.	""	0	#FFFFFF
D057831	C01.150.252.400.388.350.700|C07.550.174|C09.775.262|C14.907.355.830.925.770.500|C14.907.617.718.788.500|C14.907.940.740.910.500	Lemierre Syndrome	A superinfection of the damaged oropharyngeal mucosa by FUSOBACTERIUM NECROPHORUM leading to the secondary septic THROMBOPHLEBITIS of the internal jugular vein.	""	0	#FFFFFF
D057851	C11.297.500	Posterior Capsular Rupture, Ocular	A breach in the continuity of the posterior chamber of the eyeball.	""	0	#FFFFFF
D057867	C14.907.055.501|C23.550.414.941.500|C23.550.767.850.500	Endoleak	Postoperative hemorrhage from an endovascular AORTIC ANEURYSM repaired with endoluminal placement of stent grafts (BLOOD VESSEL PROSTHESIS IMPLANTATION). It is associated with pressurization, expansion, and eventual rupture of the aneurysm.	""	0	#FFFFFF
D057868	C23.550.767.071	Anastomotic Leak	Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.	""	0	#FFFFFF
D057873	C07.465.714.282	Peri-Implantitis	An inflammatory process with loss of supporting bone in the tissues surrounding functioning DENTAL IMPLANTS.	""	0	#FFFFFF
D057885	C23.550.210.702.500	Triploidy	Polyploidy with three sets of chromosomes. Triploidy in humans are 69XXX, 69XXY, and 69XYY. It is associated with HOLOPROSENCEPHALY; ABNORMALITIES, MULTIPLE; PARTIAL HYDATIDIFORM MOLE; and MISCARRAGES.	""	0	#FFFFFF
D057887	C07.793.494.630.500	Overbite	A malocclusion in which maxillary incisor and canine teeth project over the mandibular teeth excessively. The overlap is measured perpendicular to the occlusal plane and is also called vertical overlap. When the overlap is measured parallel to the occlusal plane it is referred to as overjet.	""	0	#FFFFFF
D057891	C23.550.210.702.249	Tetraploidy	The presence of four sets of chromosomes. It is associated with ABNORMALITIES, MULTIPLE; and MISCARRAGES.	""	0	#FFFFFF
D057896	C23.888.885.800	Striae Distensae	Linear dermal scars accompanied by epidermal atrophy that affects skin that is subjected to continuous stretching. They usually do not cause any significant medical problems, only cosmetic problems.	""	0	#FFFFFF
D057910	C23.550.470.251.500|C23.550.767.865.500	Implant Capsular Contracture	The shrinkage of the foreign body encapsulation scar tissue that forms around artificial implants imbedded in body tissues.	""	0	#FFFFFF
D057925	C05.550.384|C23.550.347	Femoracetabular Impingement	A pathological mechanical process that can lead to hip failure. It is caused by abnormalities of the ACETABULUM and/or FEMUR combined with rigorous hip motion, leading to repetitive collisions that damage the soft tissue structures.	""	0	#FFFFFF
D057971	C11.297.249	Anterior Capsular Rupture, Ocular	A breach in the continuity of the ANTERIOR CHAMBER of the eyeball.	""	0	#FFFFFF
D057973	C12.050.351.968.419.815.364|C12.200.777.419.815.364|C12.950.419.815.364|C16.320.322.100|C16.320.831.271	Dent Disease	X-linked recessive NEPHROLITHIASIS characterized by HYPERCALCIURIA; HYPOPHOSPHATEMIA; NEPHROCALCINOSIS; and PROTEINURIA. It is associated with mutations in the voltage-gated chloride channel, CLC-5 (Dent Disease I). Another group of mutations associated with this disease is in phosphatidylinositol 4,5-bisphosphate-5-phosphatase gene.	""	0	#FFFFFF
D058065	C14.280.238.235|C19.246.099.625	Diabetic Cardiomyopathies	Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.	""	0	#FFFFFF
D058066	C01.150.252.819.180|C01.800.720.180|C17.800.838.765.180|C22.214	Digital Dermatitis	Highly contagious infectious dermatitis with lesions near the interdigital spaces usually in cattle. It causes discomfort and often severe lameness (LAMENESS, ANIMAL). Lesions can be either erosive or proliferative and wart-like with papillary growths and hypertrophied hairs. DICHELOBACTER NODOSUS and TREPONEMA are the most commonly associated causative agents for this mixed bacterial infection disease.	""	0	#FFFFFF
D058069	C23.550.291.890	Neglected Diseases	Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. The World Health Organization has designated six tropical infectious diseases as being neglected in industrialized countries that are endemic in many developing countries (HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA).	""	0	#FFFFFF
D058070	C23.550.291.187	Asymptomatic Diseases	Diseases that do not exhibit symptoms.	""	0	#FFFFFF
D058088	C05.651.534.500.280.500|C08.618.923|C10.668.491.175.500.149.500|C14.280.238.812|C16.320.577.280.500	Sarcoglycanopathies	Deficiencies or mutations in the genes for the SARCOGLYCAN COMPLEX subunits. A variety of phenotypes are associated with these mutations including a subgroup of autosomal recessive limb girdle muscular dystrophies, cardiomyopathies, and respiratory deficiency.	""	0	#FFFFFF
D058165	C05.660.207.103|C14.240.400.021|C14.280.400.044|C15.604.451.249|C16.131.077.019|C16.131.240.400.021|C16.131.260.019|C16.131.482.249|C16.131.621.207.103|C16.320.180.019|C19.642.482.500	22q11 Deletion Syndrome	Condition with a variable constellation of phenotypes due to deletion polymorphisms at chromosome location 22q11. It encompasses several syndromes with overlapping abnormalities including the DIGEORGE SYNDROME, VELOCARDIOFACIAL SYNDROME, and CONOTRUNCAL AMOMALY FACE SYNDROME. In addition, variable developmental problems and schizoid features are also associated with this syndrome. (From BMC Med Genet. 2009 Feb 25;10:16) Not all deletions at 22q11 result in the 22q11deletion syndrome.	""	0	#FFFFFF
D058186	C12.050.351.968.419.780.050|C12.200.777.419.780.050|C12.950.419.780.050	Acute Kidney Injury	Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	""	0	#FFFFFF
D058225	C23.300.821	Plaque, Amyloid	Accumulations of extracellularly deposited AMYLOID FIBRILS within tissues.	""	0	#FFFFFF
D058226	C23.300.823	Plaque, Atherosclerotic	Lesions formed within the walls of ARTERIES.	""	0	#FFFFFF
D058246	C14.907.653	Prehypertension	Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.	""	0	#FFFFFF
D058247	C17.800.329.937.122.348|C23.300.035.500	Loose Anagen Hair Syndrome	Benign childhood alopecia that improves spontaneously with aging. It is characterized by anagen hairs (misshapen hair bulbs and absent inner and outer root sheaths), thin, and sparse hairs that pulls out easily.	""	0	#FFFFFF
D058249	C04.700.212|C16.320.700.212	Birt-Hogg-Dube Syndrome	Autosomal dominant neoplastic syndrome characterised by genodermatosis, lung cysts, spontaneous and recurrent PNEUMOTHORAX; and RENAL CANCER. It is associated with mutations in the folliculin protein gene (FLCN protein).	""	0	#FFFFFF
D058252	C15.604.515.292.507|C17.300.200.495.772|C17.800.550.772|C18.452.584.750.487|C23.550.382.984	Necrobiotic Xanthogranuloma	A cutaneous necrobiotic disorder characterized by firm, yellow plaques or nodules, often in a periorbital distribution. It is often accompanied by an elevated ERYTHROCYTE SEDIMENTATION RATE; LEUKOPENIA; and MONOCLONAL GAMMOPATHY (IgG-kappa type) and systemic involvement.	""	0	#FFFFFF
D058267	C01.610.858.211.250	Flea Infestations	Parasitic attack by members of the order SIPHONAPTERA.	""	0	#FFFFFF
D058285	C01.610.858.211.250.800	Tungiasis	An infestation with the flea TUNGA PENETRANS causing inflammation, pruritus, and pain, in both humans and other mammals. There is a high incidence of secondary infections such as BACTEREMIA and TETANUS.	""	0	#FFFFFF
D058288	C04.588.033.740	Sister Mary Joseph's Nodule	Metastatic lesion of the UMBILICUS associated with intra-abdominal neoplasms especially of the GASTROINTESTINAL TRACT or OVARY.	""	0	#FFFFFF
D058345	C01.125|C23.550.291.187.500	Asymptomatic Infections	Infections that do not exhibit symptoms.	""	0	#FFFFFF
D058365	C01.150.703.160.175|C01.150.703.492.500	Candidiasis, Invasive	An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.	""	0	#FFFFFF
D058387	C01.150.703.160.175.500|C01.150.703.492.500.500|C01.757.360.150|C23.550.470.790.500.360.150	Candidemia	A form of invasive candidiasis where species of CANDIDA are present in the blood.	""	0	#FFFFFF
D058405	C04.557.450.795.315	Desmoplastic Small Round Cell Tumor	A rare, aggressive soft tissue sarcoma that primarily affects adolescents and young adults. It is most commonly found in the abdomen.	""	0	#FFFFFF
D058426	C23.550.722	Neointima	The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.	""	0	#FFFFFF
D058429	C01.610.335.508.700.750.380	Gnathostomiasis	Infections with nematodes of the genus GNATHOSTOMA, superfamily THELAZIOIDEA. Gnathostomiasis is a food-borne zoonosis caused by eating undercooked or raw fish or meat.	""	0	#FFFFFF
D058437	C11.768.346|C14.907.489.815	Hypertensive Retinopathy	Degenerative changes to the RETINA due to HYPERTENSION.	""	0	#FFFFFF
D058442	C11.510.245.500	Capsule Opacification	Clouding or loss of transparency of the posterior lens capsule, usually following CATARACT extraction.	""	0	#FFFFFF
D058447	C11.300.500|C23.888.307.625|C23.888.592.612.316	Eye Pain	A dull or sharp painful sensation associated with the outer or inner structures of the eyeball, having different causes.	""	0	#FFFFFF
D058456	C11.768.748|C14.907.823.502	Retinal Telangiectasis	A group of rare, idiopathic, congenital retinal vascular anomalies affecting the retinal capillaries. It is characterized by dilation and tortuosity of retinal vessels and formation of multiple aneurysms, with different degrees of leakage and exudates emanating from the blood vessels.	""	0	#FFFFFF
D058457	C11.338.912	Trichiasis	A disease of the eye in which the eyelashes abnormally turn inwards toward the eyeball producing constant irritation caused by motion of the lids.	""	0	#FFFFFF
D058489	C12.050.351.875.253.064|C12.200.706.316.064|C12.800.316.064|C16.131.939.316.064|C19.391.119.064	46, XX Disorders of Sex Development	Congenital conditions in individuals with a female karyotype, in which the development of the gonadal or anatomical sex is atypical.	""	0	#FFFFFF
D058490	C12.050.351.875.253.096|C12.200.706.316.096|C12.800.316.096|C16.131.939.316.096|C19.391.119.096	Disorder of Sex Development, 46,XY	Congenital conditions in individuals with a male karyotype, in which the development of the gonadal or anatomical sex is atypical.	""	0	#FFFFFF
D058494	C10.500.507.450.499.249.500|C11.270.881|C16.131.666.507.450.499.249.500|C16.320.577.750	Walker-Warburg Syndrome	Rare autosomal recessive lissencephaly type 2 associated with congenital MUSCULAR DYSTROPHY and eye anomalies (e.g., RETINAL DETACHMENT; CATARACT; MICROPHTHALMOS). It is often associated with additional brain malformations such as HYDROCEPHALY and cerebellar hypoplasia and is the most severe form of the group of related syndromes (alpha-dystroglycanopathies) with common congenital abnormalities in the brain, eye and muscle development.	""	0	#FFFFFF
D058495	C16.131.077.889|C16.131.260.905|C16.320.180.905	Sotos Syndrome	Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.	""	0	#FFFFFF
D058496	C10.281.900|C16.131.077.879|C16.131.260.887|C16.320.180.887	Smith-Magenis Syndrome	Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.	""	0	#FFFFFF
D058497	C05.116.099.370.894.819.428|C05.660.585.800.428|C05.660.906.819.428|C11.250.390|C12.050.351.875.397|C12.200.706.410|C12.800.410|C16.131.077.371|C16.131.384.442|C16.131.621.585.800.428|C16.131.621.906.819.428|C16.131.939.410	Fraser Syndrome	Rare autosomal recessive congenital malformation syndrome characterized by cryptophthalmos, SYNDACTYLY and UROGENITAL ABNORMALITIES. Other anomalies of bone, ear, lung, and nose are common. Mutations on FRAS1 and FREM2 are associated with the syndrome.	""	0	#FFFFFF
D058499	C11.768.585.658	Retinal Dystrophies	A group of disorders involving predominantly the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the RETINA; RETINAL PIGMENT EPITHELIUM; BRUCH MEMBRANE; CHOROID; or a combination of these tissues.	""	0	#FFFFFF
D058502	C10.500.680.705|C16.131.077.696|C16.131.666.680.705	Pentalogy of Cantrell	Rare congenital deformity syndrome characterized by a combination of five anomalies as a result of neural tube defect. The five anomalies are a midline supraumbilical abdominal wall defect (e.g., OMPHALOCELE), a lower STERNUM defect, a congenital intracardiac defect, an anterior DIAPHRAGM defect, and a diaphragmatic PERICARDIUM defect (e.g., PERICARDIAL EFFUSION). Variants with incomplete and variable combinations of the defects are known. ECTOPIA CORDIS; CLEFT LIP; and CLEFT PALATE are often associated with the syndrome.	""	0	#FFFFFF
D058527	C04.557.386.480.750.099|C15.604.515.569.480.750.399|C20.683.515.761.480.750.199	Enteropathy-Associated T-Cell Lymphoma	A primary peripheral T-cell lymphoma in the gastrointestinal tract, most often in the jejunum, associated with a history of CELIAC DISEASE or other gastrointestinal diseases.	""	0	#FFFFFF
D058529	C14.240.850.976|C16.131.240.850.952	Single Umbilical Artery	Congenital abnormality where one, instead of the usual two, UMBILICAL ARTERY connects the fetus to the placenta.	""	0	#FFFFFF
D058531	C12.050.351.875.253.064.124|C12.200.706.316.064.124|C12.800.316.064.124|C16.131.939.316.064.124|C19.391.119.064.124	46, XX Testicular Disorders of Sex Development	Congenital conditions in individuals in which male GONADS develop in a genetic female (female to male sex reversal).	""	0	#FFFFFF
D058533	C12.050.351.875.253.795|C12.200.706.316.795|C12.800.316.795|C16.131.260.830.835|C16.131.939.316.795|C16.320.180.830.835|C19.391.119.795	Sex Chromosome Disorders of Sex Development	Congenital conditions of atypical sexual development associated with abnormal sex chromosome constitutions including MONOSOMY; TRISOMY; and MOSAICISM.	""	0	#FFFFFF
D058535	C12.050.703.277.050|C16.300.050	Echogenic Bowel	A PRENATAL ULTRASONOGRAPHY finding of excessively dense fetal bowel due to MECONIUM buildup.	""	0	#FFFFFF
D058536	C12.050.703.277.838|C16.131.939.831|C16.300.895	Pyelectasis	Dilation of fetal KIDNEY PELVIS. It is a common PRENATAL ULTRASONOGRAPHY finding with no significant long-term sequelae.	""	0	#FFFFFF
D058540	C10.500.034.687|C11.270.019|C16.131.162|C16.131.666.034.687|C16.320.290.019|C16.320.322.030	Aicardi Syndrome	A rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM, resulting in infantile spasms, MENTAL RETARDATION, and lesions of the RETINA or OPTIC NERVE.	""	0	#FFFFFF
D058545	C25.775.467	Inhalant Abuse	Illicit use of chemicals and products whose vapors can be inhaled to produce a rapid mind-altering effect. Inhalants include aerosols, gases, and volatile solvents that are often inhaled repeatedly to achieve the short-lived intoxicating effect.	""	0	#FFFFFF
D058565	C01.207.245.169|C10.228.140.430.249|C10.228.228.245.169|C10.586.250.249	Cerebral Ventriculitis	Inflammation of CEREBRAL VENTRICLES.	""	0	#FFFFFF
D058566	C05.550.114.854	Sacroiliitis	Inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.	""	0	#FFFFFF
D058568	C17.800.551|C23.888.885.468	Necrolytic Migratory Erythema	Recurrent cutaneous manifestation of GLUCAGONOMA characterized by necrolytic polycyclic migratory lesions with scaling borders. It is associated with elevated secretion of GLUCAGON by the tumor. Other conditions with elevated serum glucagon levels such as HEPATIC CIRRHOSIS may also result in similar skin lesions, which are referred to as pseudoglucagonoma syndrome.	""	0	#FFFFFF
D058606	C23.300.190	Accessory Atrioventricular Bundle	Extra impulse-conducting tissue in the heart that creates abnormal impulse-conducting connections between HEART ATRIA and HEART VENTRICLES.	""	0	#FFFFFF
D058617	C04.557.386.150|C04.557.435.295|C15.604.515.569.150|C20.683.515.761.150	Composite Lymphoma	Two or more distinct types of malignant lymphoid tumors occurring within a single organ or tissue at the same time. It may contain different types of non-Hodgkin lymphoma cells or both Hodgkin and non-Hodgkin lymphoma cells.	""	0	#FFFFFF
D058625	C06.552.308.500.177	End Stage Liver Disease	Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.	""	0	#FFFFFF
D058627	C05.660.207.536|C10.500.507.400.249|C16.131.621.207.532|C16.131.666.507.400.249	Megalencephaly	A congenital abnormality in which the occipitofrontal circumference is greater than two standard deviations above the mean for a given age. It is associated with HYDROCEPHALUS; SUBDURAL EFFUSION; ARACHNOID CYSTS; or is part of a genetic condition (e.g., ALEXANDER DISEASE; SOTOS SYNDROME).	""	0	#FFFFFF
D058631	C05.116.099.708.779|C16.320.565.595.800|C16.320.812|C18.452.648.595.800	Pycnodysostosis	Rare autosomal recessive syndrome characterized by delayed closing of CRANIAL SUTURES, short stature, ACRO-OSTEOLYSIS of distal phalanges, dental and MAXILLOFACIAL ABNORMALITIES and an increase in bone density that results in frequent BONE FRACTURES. It is associated with BONE RESORPTION defect due to mutations in the lysosomal cysteine protease CATHEPSIN K.	""	0	#FFFFFF
D058670	C23.550.210.050.625|C23.550.210.182.249	Tetrasomy	The possession of four chromosomes of any one type in an otherwise diploid cell.	""	0	#FFFFFF
D058674	C23.550.210.182	Chromosome Duplication	An aberration in which an extra chromosome or a chromosomal segment is made.	""	0	#FFFFFF
D058686	C14.280.647.250.647|C14.907.585.250.647|C23.550.767.115	Coronary-Subclavian Steal Syndrome	A complication of INTERNAL MAMMARY-CORONARY ARTERY ANASTOMOSIS whereby an occlusion or stenosis of the proximal SUBCLAVIAN ARTERY causes a reversal of the blood flow away from the CORONARY CIRCULATION, through the grafted INTERNAL MAMMARY ARTERY (internal thoracic artery), and back to the distal subclavian distribution.	""	0	#FFFFFF
D058687	C14.280.383.610	Out-of-Hospital Cardiac Arrest	Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.	""	0	#FFFFFF
D058729	C14.907.137.126.307.500|C14.907.617.671	Peripheral Arterial Disease	Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.	""	0	#FFFFFF
D058734	C23.550.414.734	Exsanguination	Rapid and extreme blood loss leading to HEMORRHAGIC SHOCK.	""	0	#FFFFFF
D058736	C26.392.500.500	Intrauterine Device Migration	The shifting in position or location of an INTRAUTERINE DEVICE from its original placement.	""	0	#FFFFFF
D058739	C04.834.020	Aberrant Crypt Foci	Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.	""	0	#FFFFFF
D058745	C26.558.554.425|C26.844.150.425	Iliotibial Band Syndrome	An overuse injury causing lateral knee pain that results from repetitive friction of the iliotibial band over the lateral femoral epicondyle.	""	0	#FFFFFF
D058747	C11.270.147.500|C16.131.077.239|C16.320.165	CHARGE Syndrome	Rare disease characterized by COLOBOMA; CHOANAL ATRESIA; and abnormal SEMICIRCULAR CANALS. Mutations in CHD7 protein resulting in disturbed neural crest development are associated with CHARGE Syndrome.	""	0	#FFFFFF
D058866	C26.404.545	Osteoporotic Fractures	Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.	""	0	#FFFFFF
D058890	C12.050.703.844.603.400|C17.800.090.968.400	Granulomatous Mastitis	A rare, benign, inflammatory breast disease occurring in premenopausal women shortly after a recent pregnancy. The origin is unknown but it is commonly mistaken for malignancy and sometimes associated with BREAST FEEDING and the use of ORAL CONTRACEPTIVES.	""	0	#FFFFFF
D058922	C04.588.180.576|C17.800.090.500.576	Inflammatory Breast Neoplasms	Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.	""	0	#FFFFFF
D058923	C05.651.426|C10.668.491.087|C26.558.705	Medial Tibial Stress Syndrome	SKELETAL MUSCLE pain and tenderness along the posteromedial TIBIA resulting from exercise such as running and other physical activity.	""	0	#FFFFFF
D058926	C23.550.505.400	Intraoperative Awareness	Occurence of a patient becoming conscious during a procedure performed under GENERAL ANESTHESIA and subsequently having recall of these events. (From Anesthesiology 2006, 104(4): 847-64.)	""	0	#FFFFFF
D058968	C01.610.701.844|C22.761	Pythiosis	A granulomatous disease caused by the aquatic organism PYTHIUM insidiosum and occurring primarily in horses, cattle, dogs, cats, fishes, and rarely in humans. It is classified into three forms: ocular, cutaneous, and arterial.	""	0	#FFFFFF
D059041	C05.660.207.707|C16.131.621.207.707	Plagiocephaly	The condition characterized by uneven or irregular shape of the head often in parallelogram shape with a flat spot on the back or one side of the head. It can either result from the premature CRANIAL SUTURE closure (CRANIOSYNOSTOSIS) or from external forces (NONSYNOSTOTIC PLAGIOCEPHALY).	""	0	#FFFFFF
D059226	C23.888.592.612.720	Nociceptive Pain	Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.	""	0	#FFFFFF
D059228	C12.050.351.968.419.787|C12.200.777.419.787|C12.950.419.787	Renal Nutcracker Syndrome	Left RENAL VEIN compression between the AORTA, ABDOMINAL and the SUPERIOR MESENTERIC ARTERY. Variable symptoms include HYPERTENSION, RENOVASCULAR; HEMATURIA; and VARICOSE VEINS.	""	0	#FFFFFF
D059245	C08.381.840.500.737|C08.618.840.500.737|C08.618.961.500|C16.614.521.563.737|C23.888.852.944.500	Transient Tachypnea of the Newborn	Abnormal increase in RESPIRATORY RATE in the newborn. It is self-limiting and attributed to the delayed fetal lung fluid clearance often in CAESAREAN SECTION delivery.	""	0	#FFFFFF
D059246	C08.618.961|C23.888.852.944	Tachypnea	Increased RESPIRATORY RATE.	""	0	#FFFFFF
D059249	C01.150.703.658|C09.218.736	Otomycosis	Fungus infection of the external ear, usually by ASPERGILLUS species	""	0	#FFFFFF
D059265	C23.888.592.612.720.500	Visceral Pain	Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.	""	0	#FFFFFF
D059266	C05.116.852.087|C05.500.086|C07.320.086|C23.550.717.732.183	Bisphosphonate-Associated Osteonecrosis of the Jaw	Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.	""	0	#FFFFFF
D059268	C12.050.351.500.894.906.316|C12.100.250.894.906.316	Atrophic Vaginitis	Inflammation of the vagina due to thinning of the vaginal wall and decreased lubrication associated with reduced estrogen levels at MENOPAUSE.	""	0	#FFFFFF
D059269	C06.405.469.158.093	Chilaiditi Syndrome	Interposition of a portion of the colon (e.g., SIGMOID COLON) between the liver and the diaphragm. It is associated with abdominal pain, vomiting, constipation, anorexia and volvulus. Chilaiditi anomaly refers to asymptomatic interposition.	""	0	#FFFFFF
D059270	C01.160.495.750|C05.116.165.495.500|C09.218.705.663.841	Petrositis	Inflammation of PETROUS BONE.	""	0	#FFFFFF
D059325	C05.651.180.297|C14.907.303.297	Intra-Abdominal Hypertension	Pathological elevation of intra-abdominal pressure (>12 mm Hg). It may develop as a result of SEPSIS; PANCREATITIS; capillary leaks, burns, or surgery. When the pressure is higher than 20 mm Hg, often with end-organ dysfunction, it is referred to as abdominal compartment syndrome.	""	0	#FFFFFF
D059327	C05.660.585.262|C16.131.621.585.262	Brachydactyly	Congenital anomaly of abnormally short fingers or toes.	""	0	#FFFFFF
D059345	C10.228.140.300.275|C14.907.253.329	Cerebral Small Vessel Diseases	Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE.	""	0	#FFFFFF
D059347	C12.050.351.968.419.780.400|C12.200.777.419.780.400|C12.950.419.780.400|C14.280.434.156	Cardio-Renal Syndrome	Condition where a primary dysfunction of either heart or kidney results in failure of the other organ (e.g., HEART FAILURE with worsening RENAL INSUFFICIENCY).	""	0	#FFFFFF
D059348	C10.668.829.712|C10.900.575|C26.915.650	Peripheral Nerve Injuries	Injuries to the PERIPHERAL NERVES.	""	0	#FFFFFF
D059350	C23.888.592.612.274	Chronic Pain	Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.	""	0	#FFFFFF
D059352	C05.651.538|C23.888.592.612.547	Musculoskeletal Pain	Discomfort stemming from muscles, LIGAMENTS, tendons, and bones.	""	0	#FFFFFF
D059366	C08.127.108.495|C08.674.095.495|C20.543.480.680.095.495|C24.102	Asthma, Occupational	Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.	""	0	#FFFFFF
D059369	C01.160.495.875|C05.116.165.495.750|C11.675.689	Pott Puffy Tumor	Infection of the FRONTAL BONE often as a complication of FRONTAL SINUSITIS or trauma to the frontal bone and skull. It is characterized by subperiosteal abscess with OSTEOMYELITIS.	""	0	#FFFFFF
D059373	C23.888.592.612.530	Mastodynia	Pain in the breast generally classified as cyclical (associated with menstrual periods), or noncyclical, i.e. originating from the breast or nearby muscles or joints, ranging from minor discomfort to severely incapacitating.	""	0	#FFFFFF
D059388	C23.888.592.612.547.500|C23.888.592.612.944.625	Pelvic Girdle Pain	Discomfort associated with the bones that make up the pelvic girdle. It occurs frequently during pregnancy.	""	0	#FFFFFF
D059390	C23.888.592.612.191	Breakthrough Pain	Acute pain that comes on rapidly despite the use of pain medication.	""	0	#FFFFFF
D059407	C11.187.631	Pinguecula	A yellowish thickened lesion on the conjunctiva near the CORNEA representing a benign degenerative change in the CONJUNCTIVA caused by the leakage and deposition of certain blood proteins through the permeable capillaries near the LIMBUS.	""	0	#FFFFFF
D059409	C10.228.140.300.275.800|C10.228.140.300.775.400.750.500|C14.907.253.329.800|C14.907.253.855.400.750.500|C23.550.513.355.250.600|C23.550.717.489.250.600	Stroke, Lacunar	Stroke caused by lacunar infarction or other small vessel diseases of the brain. It features hemiparesis (see PARESIS), hemisensory, or hemisensory motor loss.	""	0	#FFFFFF
D059411	C23.888.942.343	Lower Urinary Tract Symptoms	Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.	""	0	#FFFFFF
D059413	C01.463	Intraabdominal Infections	Infection within the PERITONEAL CAVITY. A frequent cause is an ANASTOMOTIC LEAK following surgery.	""	0	#FFFFFF
D059445	C10.597.606.057|C23.888.592.604.039	Anhedonia	Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).	""	0	#FFFFFF
D059446	C14.240.400.592|C14.280.400.592|C15.604.744.146|C16.131.077.401|C16.131.240.400.592	Heterotaxy Syndrome	Abnormal thoracoabdominal VISCERA arrangement (visceral heterotaxy) or malformation that involves additional CONGENITAL HEART DEFECTS (e.g., heart isomerism; DEXTROCARDIA) and/or abnormal SPLEEN (e.g., asplenia and polysplenia). Irregularities with the central nervous system, the skeleton and urinary tract are often associated with the syndrome.	""	0	#FFFFFF
D059466	C14.907.489.907	White Coat Hypertension	Phenomenon where BLOOD PRESSURE readings are elevated only when taken in clinical settings.	""	0	#FFFFFF
D059468	C14.907.489.861	Masked Hypertension	Phenomenon where increased BLOOD PRESSURE readings taken in non-clinical settings (e.g., HOME BLOOD PRESSURE MONITORING) do not replicate in clinical settings.	""	0	#FFFFFF
D059525	C01.748.798|C08.360.840|C08.730.798|C09.400.840	Supraglottitis	Inflammation of the EPIGLOTTIS and supraglottic structures including the PHARYNX; UVULA; base of tongue; and aryepiglottic folds. It is usually caused by HAEMOPHILUS INFLUENZAE in children but often by different organisms in adults.	""	0	#FFFFFF
D059545	C04.588.364.738|C04.730.900|C11.319.466	Paraneoplastic Syndromes, Ocular	Ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions.	""	0	#FFFFFF
D059606	C23.550.759|C23.888.663	Polydipsia	Excessive thirst manifested by excessive fluid intake. It is characteristic of many diseases such as DIABETES MELLITUS; DIABETES INSIPIDUS; and NEPHROGENIC DIABETES INSIPIDUS. The condition may be psychogenic in origin.	""	0	#FFFFFF
D059607	C23.550.759.500|C23.888.663.500	Polydipsia, Psychogenic	A clinical disorder characterized by excessive fluid intake (polydipsia); HYPONATREMIA; and POLYURIA in SCHIZOPHRENIA and other psychiatric disorders. Impaired water metabolism in psychogenic polydipsia can result in WATER INTOXICATION.	""	0	#FFFFFF
D059608	C08.360.549|C08.695.520|C09.400.549|C16.131.740.650	Laryngocele	Congenital anomalous dilitation of the laryngeal saccule that may extend internally into the airway or externally through the thyrohyoid membrane.	""	0	#FFFFFF
D059707	C01.150.252.400.050	Aliivibrio Infections	Infections with bacteria of the genus ALIIVIBRIO.	""	0	#FFFFFF
D059786	C23.550.210.024	Abnormal Karyotype	A variation from the normal set of chromosomes characteristic of a species.	""	0	#FFFFFF
D059787	C23.888.592.612.081	Acute Pain	Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.	""	0	#FFFFFF
D059885	C04.557.645.375.617|C15.378.140.855.645	Kasabach-Merritt Syndrome	Rapidly growing vascular lesion along the midline axis of the neck, upper trunk, and extremities that is characterized by CONSUMPTION COAGULOPATHY; THROMBOCYTOPENIA; and HEMOLYTIC ANEMIA. It is often associated with infantile Kaposiform HEMANGIOENDOTHELIOMA and other vascular tumors such as tufted ANGIOMA.	""	0	#FFFFFF
D059905	C14.280.282.703	Endocarditis, Non-Infective	Formation of a non-infectious THROMBUS, referred to as vegetation, on previously undamaged ENDOCARDIUM. It usually occurs as a complication of connective-tissue diseases and cancers because of the associated hypercoagulable state (see THROMBOPHILIA).	""	0	#FFFFFF
D059952	C12.050.351.625|C12.050.703.565|C12.200.483|C12.400	Pelvic Floor Disorders	Injury, weakening, or PROLAPSE of the pelvic muscles, surrounding connective tissues or ligaments (PELVIC FLOOR).	""	0	#FFFFFF
D060048	C05.116.099.708.928|C05.116.425.500	Slipped Capital Femoral Epiphyses	A developmental deformity in which the metaphysis of the FEMUR moves proximally and anteriorly away from FEMUR HEAD (epiphysis) at the upper GROWTH PLATE. It is most common in male adolescents and is associated with a greater risk of early OSTEOARTHRITIS of the hip.	""	0	#FFFFFF
D060050	C14.280.647.187.362|C14.907.585.187.362|C23.888.592.612.233.500.575	Angina, Stable	Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.	""	0	#FFFFFF
D060051	C26.716	Occupational Injuries	Injuries sustained from incidents in the course of work-related activities.	""	0	#FFFFFF
D060085	C01.218	Coinfection	Simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses.	""	0	#FFFFFF
D060368	C01.150.703.302.475|C01.800.200.475|C17.800.838.208.475	Lobomycosis	A chronic, fungal, subcutaneous infection endemic in rural regions in South America and Central America. The causal organism is Lacazia labol.	""	0	#FFFFFF
D060425	C01.150.703.302.383.375|C01.800.200.383.375|C17.800.838.208.416.375	Cerebral Phaeohyphomycosis	CNS infections caused by neurotropic dematiaceous fungi that contain melanin in their cell walls. The infections often result in BRAIN ABSCESS; ENCEPHALITIS; and MENINGITIS in patients who are often immunocompetent. The common causative fungi include members Cladophialophora bantiana, Exophiala dermatitidis, Rhinocladiella mackenziei, and Ochroconis gallopavum. R. mackenziei infection is seen almost exclusively in patients from the MIDDLE EAST.	""	0	#FFFFFF
D060426	C04.588.614.550.112|C04.730.856.112|C10.228.140.430.124|C10.574.781.249|C10.586.250.124|C20.111.258.124	Anti-N-Methyl-D-Aspartate Receptor Encephalitis	Disorder characterized by symptoms of CATATONIA; HYPOVENTILATION; DYSKINESIAS; ENCEPHALITIS; and SEIZURES followed by a reduced CONSCIOUSNESS. It is often followed by a viral-like prodrome. Many cases are self-limiting and respond well to IMMUNOMODULATORY THERAPIES against the NMDA RECEPTORS antibodies.	""	0	#FFFFFF
D060437	C11.510.174|C26.392.500.249	Artificial Lens Implant Migration	The shifting and or tilting of implanted artificial lens resulting in impaired vision.	""	0	#FFFFFF
D060446	C01.150.703.726	Phaeohyphomycosis	OPPORTUNISTIC INFECTIONS caused by the dematiaceous (darkly pigmented) MITOSPORIC FUNGI of ALTERNARIA, Bipolaris, CLADOSPORIUM, Curvularia, and EXOPHIALA. These fungi have pigmented HYPHAE due to MELANIN in the cell wall. The initial subcutaneous cyst from the infection can become systemic and spread rapidly to renal, pulmonary and cerebral systems (see CEREBRAL PHAEOHYPHOMYCOSIS) in an IMMUNOCOMPROMISED HOST.	""	0	#FFFFFF
D060467	C23.550.291.671	Disease Resistance	The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.	""	0	#FFFFFF
D060486	C10.228.140.546.399.750.725|C10.292.562.750.375|C10.292.675|C10.314.687|C10.597.622.447.600|C11.590.472.375|C23.888.592.636.447.600	Ophthalmoplegic Migraine	Childhood-onset of recurrent headaches with an oculomotor cranial nerve palsy. Typically, ABDUCENS NERVE; OCULOMOTOR NERVE; and TROCHLEAR NERVE are involved with DIPLOPIA and BLEPHAROPTOSIS.	""	0	#FFFFFF
D060487	C01.150.703.302.383.125|C01.800.200.383.125|C17.800.838.208.416.125	Alternariosis	Opportunistic fungal infection by a member of ALTERNARIA genus.	""	0	#FFFFFF
D060545	C10.668.829.550.650|C10.668.829.600.737|C23.888.592.612.664.737	Pudendal Neuralgia	Pain associated with a damaged PUDENDAL NERVE. Clinical features may include positional pain with sitting in the perineal and genital areas, sexual dysfunction and FECAL INCONTINENCE and URINARY INCONTINENCE.	""	0	#FFFFFF
D060585	C01.150.703.302.383.500|C01.800.200.383.500|C17.800.838.208.416.500	Fusariosis	OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.	""	0	#FFFFFF
D060586	C01.150.703.875|C08.381.483.125.841|C08.674.055.682|C20.543.480.680.075.682	Trichosporonosis	Fungal infections caused by TRICHOSPORON that may become systemic especially in an IMMUNOCOMPROMISED HOST. Clinical manifestations range from superficial cutaneous infections to systemic lesions in multiple organs.	""	0	#FFFFFF
D060605	C01.150.703.302.383|C01.800.200.383|C17.800.838.208.416	Hyalohyphomycosis	OPPORTUNISTIC INFECTIONS caused by a heterogeneous group of MITOSPORIC FUNGI with clear (hyalo-) HYPHAE in the host. Common causative agents include ACREMONIUM; ASPERGILLUS; CHRYSOSPORIUM; FUSARIUM; PAECILOMYCES; PENICILLIUM; PSEUDALLESCHERIA; SCEDOSPORIUM; and SCOPULARIOPSIS. Normally a dermatomycoses, it can become invasive in the IMMUNOCOMPROMISED HOST.	""	0	#FFFFFF
D060705	C10.597.606.150.550.099|C23.888.592.604.150.550.099	Dyscalculia	Impaired ability in numerical concepts. These inabilities arise as a result of primary neurological lesion, are syndromic (e.g., GERSTMANN SYNDROME ) or acquired due to brain damage.	""	0	#FFFFFF
D060725	C12.050.351.500.852.900|C12.100.250.852.900|C23.300.970.750	Uterine Retroversion	A condition in which the UTERUS is found tilted backward toward the spine. The uterus is more commonly found in a straight vertical or anteverted (tipped forward) position. Although retroverted uterus is a normal variant position without symptoms, it is sometimes associated with pain, discomfort and other pregnancy complications.	""	0	#FFFFFF
D060737	C01.730|C12.050.351.500.630|C12.100.250.630|C12.100.500.604|C12.200.294.604	Reproductive Tract Infections	Infections of the genital tract in females or males. They can be caused by endogenous, iatrogenic, or sexually transmitted organisms.	""	0	#FFFFFF
D060750	C05.116.214.500|C23.300.970.249	Bone Anteversion	Malalignment of a bone in which its head and neck is rotated excessively forward or inward.	""	0	#FFFFFF
D060751	C05.116.214.750|C23.300.970.374	Bone Retroversion	Attachment of a bone in which its head and neck is rotated excessively backward.	""	0	#FFFFFF
D060831	C17.800.174.600.587|C25.100.468.380.587	Hand-Foot Syndrome	Chemotherapy-induced dermal side effects that are associated with the use of various CYTOSTATIC AGENTS. Symptoms range from mild ERYTHEMA and/or PARESTHESIA to severe ulcerative dermatitis with debilitating pain involving typically palmoplantar and intertriginous areas. These cutaneous manifestations are sometimes accompanied by nail anomalies.	""	0	#FFFFFF
D060905	C05.116.214.500.500|C23.300.970.249.500	Coxa Vara	Hip deformity in which the femoral neck leans forward resulting in a decrease in the angle between femoral neck and its shaft. It may be congenital often syndromic, acquired, or developmental.	""	0	#FFFFFF
D060906	C05.116.214.750.500|C05.116.327|C23.300.970.374.500	Coxa Valga	Hip deformity in which the angle between the femoral neck and its shaft is increased. It may be congenital, acquired, or developmental.	""	0	#FFFFFF
D061085	C10.500.034|C16.131.666.034|C23.300.008	Agenesis of Corpus Callosum	Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.	""	0	#FFFFFF
D061205	C18.452.174.130.780	Vascular Calcification	Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.	""	0	#FFFFFF
D061206	C04.697.650.695|C23.550.727.650.695	Neoplasm Micrometastasis	Newly arising secondary tumors so small they are difficult to detect by physical examination or routine imaging techniques.	""	0	#FFFFFF
D061219	C10.292.200.687|C10.292.650.600|C10.900.300.218.487|C26.915.300.400.562	Olfactory Nerve Injuries	Traumatic injuries to the OLFACTORY NERVE. It may result in various olfactory dysfunction including a complete loss of smell.	""	0	#FFFFFF
D061220	C10.292.200.656|C10.292.562.700.500|C10.900.300.218.456|C11.590.436.600|C26.915.300.400.518	Oculomotor Nerve Injuries	Traumatic injuries to the OCULOMOTOR NERVE. This may result in various eye movement dysfunction.	""	0	#FFFFFF
D061221	C07.465.299.625.500.349|C10.292.200.875|C10.292.319.625.700.349|C10.900.300.218.775|C26.915.300.400.825	Trigeminal Nerve Injuries	Traumatic injuries to the TRIGEMINAL NERVE. It may result in extreme pain, abnormal sensation in the areas the nerve innervates on face, jaw, gums and tongue and can cause difficulties with speech and chewing. It is sometimes associated with various dental treatments.	""	0	#FFFFFF
D061222	C07.465.299.625.500.349.500|C10.292.200.875.500|C10.292.319.625.700.349.500|C10.900.300.218.775.500|C26.915.300.400.825.500	Lingual Nerve Injuries	Traumatic injuries to the LINGUAL NERVE. It may be a complication following dental treatments.	""	0	#FFFFFF
D061223	C10.292.200.937|C10.292.887.399|C10.900.300.218.887|C26.915.300.400.912	Vagus Nerve Injuries	Traumatic injuries to the VAGUS NERVE. Because the vagus nerve innervates multiple organs, injuries in the nerve fibers may result in any gastrointestinal organ dysfunction downstream of the injury site.	""	0	#FFFFFF
D061224	C08.360.424|C09.400.424|C10.292.200.937.750|C10.900.300.218.887.750|C26.915.300.400.912.750	Laryngeal Nerve Injuries	Traumatic injuries to the LARYNGEAL NERVE.	""	0	#FFFFFF
D061226	C08.360.424.500|C09.400.424.500|C10.292.200.937.750.500|C10.900.300.218.887.750.500|C26.915.300.400.912.750.500	Recurrent Laryngeal Nerve Injuries	Traumatic injuries to the RECURRENT LARYNGEAL NERVE that may result in vocal cord dysfunction.	""	0	#FFFFFF
D061227	C10.292.175.500|C10.292.200.350|C10.900.300.218.225|C26.915.300.400.200	Accessory Nerve Injuries	Traumatic injuries to the ACCESSORY NERVE. Damage to the nerve may produce weakness in head rotation and shoulder elevation.	""	0	#FFFFFF
D061228	C10.292.200.562|C10.292.525.500|C10.900.300.218.362|C26.915.300.400.387	Hypoglossal Nerve Injuries	Traumatic injuries to the HYPOGLOSSAL NERVE.	""	0	#FFFFFF
D061247	C10.292.200.906|C10.900.300.218.831|C26.915.300.400.868	Trochlear Nerve Injuries	Traumatic injuries to the TROCHLEAR NERVE.	""	0	#FFFFFF
D061270	C08.460.595|C09.603.588|C26.670	Nasal Septal Perforation	An opening or hole in the NASAL SEPTUM that is caused by TRAUMA, injury, drug use, or pathological process.	""	0	#FFFFFF
D061285	C09.218.807.800.918|C10.292.200.968|C10.292.910.925|C10.900.300.218.943|C26.915.300.400.956	Vestibulocochlear Nerve Injuries	Traumatic injuries to the VESTIBULOCOCHLEAR NERVE.	""	0	#FFFFFF
D061287	C10.292.200.531|C10.292.450.500|C10.900.300.218.331|C26.915.300.400.343	Glossopharyngeal Nerve Injuries	Traumatic injuries to the GLOSSOPHARYNGEAL NERVE.	""	0	#FFFFFF
D061325	C04.588.180.483|C04.588.322.455.431|C04.700.517|C12.050.351.500.056.630.705.431|C12.050.351.937.418.685.431|C12.100.250.056.630.705.431|C12.900.418.685.431|C16.320.700.517|C17.800.090.500.483|C19.344.410.431|C19.391.630.705.431	Hereditary Breast and Ovarian Cancer Syndrome	Autosomal dominant HEREDITARY CANCER SYNDROME in which a mutation most often in either BRCA1 or BRCA2 is associated with a significantly increased risk for breast and ovarian cancers.	""	0	#FFFFFF
D061387	C01.150.252.400.210.125.123|C01.150.252.400.210.250.299|C01.150.252.620.249|C01.748.610.540.249|C08.381.677.540.249|C08.730.610.540.249	Chlamydial Pneumonia	Pneumonia caused by infections with the genus CHLAMYDIA; and CHLAMYDOPHILA, usually with CHLAMYDOPHILA PNEUMONIAE.	""	0	#FFFFFF
D061686	C12.100.500.530|C12.100.875.743|C12.200.294.530	Premature Ejaculation	The emission of SEMEN and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration.	""	0	#FFFFFF
D062025	C25.723.717	Organophosphate Poisoning	Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.	""	0	#FFFFFF
D062026	C10.228.140.546.399.750.124|C10.597.606.762.150|C10.597.751.941.036|C23.888.592.604.764.150|C23.888.592.763.941.036	Alice in Wonderland Syndrome	Neurological condition characterized by disturbances in VISUAL PERCEPTION, most often of BODY SCHEMA, TIME PERCEPTION and HALLUCINATIONS. It is associated with MIGRAINE, infections (e.g., INFECTIOUS MONONUCLEOSIS), FEVER, EPILEPSY, and other neurological and psychiatric disorders.	""	0	#FFFFFF
D062027	C17.800.865.622|C20.111.585	Linear IgA Bullous Dermatosis	Autoimmune disease characterized by subepidermal blisters and linear deposition of autoantibodies at the dermoepidermal junction. The accumulated autoantibodies are of IMMUNOGLOBULIN A and occasionally IMMUNOGLOBULIN G classes against epidermal BASEMENT MEMBRANE proteins. The dermatosis is sometimes associated with malignancies and use of certain drugs (e.g., VANCOMYCIN).	""	0	#FFFFFF
D062108	C14.240.850.906|C14.907.617.648|C16.131.240.850.890	May-Thurner Syndrome	A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation.	""	0	#FFFFFF
D062625	C04.557.450.565.590.595.050.500|C04.557.470.590.482|C04.557.470.625.050.500	Cystadenofibroma	Benign or borderline malignant neoplasm of the ovary and surrounding tissues. It is characterized by tumor(s) with cystic glands which are lined by cuboidal EPITHELIAL CELLS with clear cytoplasm, resembling ENDOMETRIUM cells. The glands are separated by fibroblastic STROMAL CELLS.	""	0	#FFFFFF
D062685	C16.131.831.350.856.500|C16.320.850.250.856.500|C17.800.529.594.500|C17.800.804.350.856.500|C17.800.827.250.856.500	Steatocystoma Multiplex	A disorder characterized by multiple, wide spread cutaneous cysts that often become inflamed and rupture. It is caused by the same mutations in the gene coding for KRT-17 that are causative mutations for Pachyonychia congenita, Type 2. Natal teeth involvement is sometimes associated with steatocystoma multiplex.	""	0	#FFFFFF
D062688	C01.221.812.640.220.500|C01.778.640.220.500|C01.925.256.650.810.217.500|C01.925.813.220.500|C01.925.825.810.110.500|C01.925.928.914.217.500|C04.557.470.200.450.500|C04.557.470.700.450.500|C12.100.937.640.220.500|C17.800.838.790.810.110.500	Buschke-Lowenstein Tumor	Exophytic tumor of the anogenital region associated with HPV infections. It becomes a large cauliflower-like, hyperkeratotic, verrucous mass that is locally destructive with little atypical cells. Histologically, tumor cells are broad rete peg structures that tend to invade deeper than CONDYLOMATA ACUMINATA.	""	0	#FFFFFF
D062689	C04.557.450.550.400.500	Lipoblastoma	Benign tumors of fatty tissues found in infancy and childhood. It is associated chromosomal aberrations that result in activation of an oncogene on chromosome band 8q12.	""	0	#FFFFFF
D062706	C23.888.672	Prodromal Symptoms	Clinical or physiological indicators that precede the onset of disease.	""	0	#FFFFFF
D062787	C25.775.383	Drug Overdose	Accidental or deliberate use of a medication or street drug in excess of normal dosage.	""	0	#FFFFFF
D062788	C12.050.351.500.852.113|C12.100.250.852.113	Adenomyosis	The extension of endometrial tissue (ENDOMETRIUM) into the MYOMETRIUM. It usually occurs in women in their reproductive years and may result in a diffusely enlarged uterus with ectopic and benign endometrial glands and stroma.	""	0	#FFFFFF
D062846	C15.604.496.660	Non-Filarial Lymphedema	A form of elephantiasis caused by soil particles which penetrate the skin of the foot. It is limited to tropical regions with soils of high volcanic content.	""	0	#FFFFFF
D063129	C23.550.260.730	Parental Death	The death of the father or mother or another person in this role.	""	0	#FFFFFF
D063130	C12.050.703.401|C23.550.260.730.500	Maternal Death	The death of the female parent.	""	0	#FFFFFF
D063169	C05.660.207.540.229|C07.650.500.229|C16.131.621.207.540.315|C16.131.850.500.229	Dentofacial Deformities	An abnormality of the jaws or teeth affecting the contour of the face. Such abnormality could be acquired or congenital.	""	0	#FFFFFF
D063173	C05.500.460.827|C05.660.207.540.460.827|C07.320.440.827|C07.320.610.827|C07.650.500.460.827|C16.131.621.207.540.460.827|C16.131.850.500.460.827	Retrognathia	A physical misalignment of the upper (maxilla) and lower (mandibular) jaw bones in which either or both recede relative to the frontal plane of the forehead.	""	0	#FFFFFF
D063192	C12.050.703.733.650	Pregnancy, Heterotopic	MULTIPLE PREGNANCY with EMBRYO IMPLANTATION occuring at different locations, involving both an intrauterine site and an extrauterine (ECTOPIC PREGNANCY) site.	""	0	#FFFFFF
D063205	C10.228.854.583	Pneumorrhachis	Presence of air or gas within the spinal canal cavity (EPIDURAL SPACE; or SUBARACHNOID SPACE). It may result from traumatic injuries, emphysema, infection and other conditions. It can also develop as a complication of various SURGICAL PROCEDURES (e.g., MYELOGRAPHY).	""	0	#FFFFFF
D063371	C09.218.636	Myringosclerosis	The formation of dense connective tissue in the TYMPANIC MEMBRANE that does not necessarily cause or lead to loss of hearing.	""	0	#FFFFFF
D063425	C25.775.100.437	Binge Drinking	Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.	""	0	#FFFFFF
D063466	C06.405.117.119.500.484.500.500|C08.618.749.500|C23.550.773.500	Respiratory Aspiration of Gastric Contents	Inhaling refluxed gastric or duodenal contents.	""	0	#FFFFFF
D063485	C01.610.335.508.700.750.361.137	Acanthocheilonemiasis	A tropical infectious disease found mainly in Africa that is caused by the filarial parasite ACANTHOCHEILONEMA. Symptoms include skin rashes, abdominal, chest, muscle, and joint pains, neurologic disorders, skin lumps, and elevated levels of white blood cells. The parasite is transmitted through the bite of small flies.	""	0	#FFFFFF
D063646	C04.697.098|C23.550.727.098	Carcinogenesis	The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	""	0	#FFFFFF
D063647	C12.050.703.277.220|C16.300.070|C25.775.100.087.323	Fetal Alcohol Spectrum Disorders	An umbrella term used to describe a pattern of disabilities and abnormalities that result from fetal exposure to ETHANOL during pregnancy. It encompasses a phenotypic range that can vary greatly between individuals, but reliably includes one or more of the following: characteristic facial dysmorphism, FETAL GROWTH RETARDATION, central nervous system abnormalities, cognitive and/or behavioral dysfunction, BIRTH DEFECTS. The level of maternal alcohol consumption does not necessarily correlate directly with disease severity.	""	0	#FFFFFF
D063730	C05.116.198.816.875|C18.452.104.816.875|C18.452.174.845.875|C18.452.750.400.750|C18.654.521.500.133.770.734.875	Rickets, Hypophosphatemic	A disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; resulting from lack of phosphate reabsorption by the kidneys and possible defects in vitamin D metabolism.	""	0	#FFFFFF
D063748	C14.240.400.210.249|C14.240.850.984.500.500|C14.280.400.210.249|C14.907.933.110.500|C16.131.240.400.210.249|C16.131.240.850.500.500|C23.300.575.950.150.500	Bland White Garland Syndrome	A congenital coronary vessel anomaly in which the left main CORONARY ARTERY originates from the PULMONARY ARTERY instead of from AORTA. The congenital heart defect typically results in coronary artery FISTULA; LEFT-SIDED HEART FAILURE and MITRAL VALVE INSUFFICIENCY during the first months of life.	""	0	#FFFFFF
D063766	C18.654.726.750.500.720|C23.888.144.699.500.750	Pediatric Obesity	BODY MASS INDEX in children (ages 2-12) and in adolescents (ages 13-18) that is grossly above the recommended cut-off for a specific age and sex. For infants less than 2 years of age, obesity is determined based on standard weight-for-length percentile measures.	""	0	#FFFFFF
D063806	C05.651.542|C10.668.491.525|C23.888.592.612.547.249	Myalgia	Painful sensation in the muscles.	""	0	#FFFFFF
D063807	C17.800.174.146|C17.800.738.353	Dandruff	Excessive shedding of dry scaly material from the scalp in humans.	""	0	#FFFFFF
D063926	C17.800.174.600.262|C20.543.206.380.262|C25.100.468.380.262	Drug Hypersensitivity Syndrome	Severe drug eruption characterized by high fever, erythematous rash and inflammation of internal organ(s).	""	0	#FFFFFF
D064068	C06.405.469.637.378|C18.452.603.314	Collagenous Sprue	A malabsorption syndrome characterized by collagenous mucosal lesions of the SMALL INTESTINE, atrophy of MICROVILLI, severe malabsorption, diarrhea, and MALNUTRITION often refractory to a gluten-free diet.	""	0	#FFFFFF
D064090	C04.557.386.435|C04.588.364.447|C15.604.515.569.417|C20.683.515.761.417	Intraocular Lymphoma	A form of malignant cancer which occurs within the eyeball.	""	0	#FFFFFF
D064128	C10.228.140.490.375.525	Nodding Syndrome	Unexplained neurologic condition characterized by episodes of atonic seizures, convulsions or staring spells with further cognitive decline.	""	0	#FFFFFF
D064129	C04.588.945.440.770.500|C12.100.500.260.750.500|C12.100.500.565.625.500|C12.200.294.260.750.500|C12.200.294.565.625.500|C12.200.758.409.750.500|C12.900.619.750.500	Prostatic Neoplasms, Castration-Resistant	Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.	""	0	#FFFFFF
D064146	C15.378.553.546.184.564.750.500	Chemotherapy-Induced Febrile Neutropenia	FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.	""	0	#FFFFFF
D064147	C15.378.553.546.184.564.750	Febrile Neutropenia	Fever accompanied by a significant reduction in the number of NEUTROPHILS.	""	0	#FFFFFF
D064250	C18.452.584.500.500.851.875|C23.888.521	Hypertriglyceridemic Waist	A screening phenotype consisting of both elevated WAIST CIRCUMFERENCE and elevated fasting TRIGLYCERIDES level.	""	0	#FFFFFF
D064386	C26.404.014	Ankle Fractures	Fractures of any of the bones of the ANKLE.	""	0	#FFFFFF
D064419	C25	Chemically-Induced Disorders	Disorders caused by the intentional or unintentional ingestion or exposure to chemical substances such as PHARMACEUTICAL PREPARATIONS; NOXAE; and PESTICIDES.	""	0	#FFFFFF
D064420	C25.100	Drug-Related Side Effects and Adverse Reactions	Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.	""	0	#FFFFFF
D064706	C08.360.895|C08.618.980|C09.400.895	Vocal Cord Dysfunction	A disorder characterized by an intermittent abnormal VOCAL CORDS movement toward the midline during inspiration or expiration resulting in upper AIRWAY OBSTRUCTION.	""	0	#FFFFFF
D064726	C04.588.180.788|C17.800.090.500.788	Triple Negative Breast Neoplasms	Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.	""	0	#FFFFFF
D064749	C12.050.351.875.811|C12.200.706.811|C12.800.811|C16.131.939.915	Retrocaval Ureter	A rare congenital abnormality resulting in the URETER passing dorsal to and being obstructed by the INFERIOR VENA CAVA.	""	0	#FFFFFF
D064752	C23.300.052|C23.550.113	Atrial Remodeling	Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE.	""	0	#FFFFFF
D064793	C23.550.863	Teratogenesis	The formation of CONGENITAL ABNORMALITIES.	""	0	#FFFFFF
D064806	C23.550.308	Dysbiosis	Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.	""	0	#FFFFFF
D064807	C25.100.311	Anticholinergic Syndrome	Adverse drug effects associated with CHOLINERGIC ANTAGONISTS. Clinical features include TACHYCARDIA; HYPERTHERMIA; MYDRIASIS, dry skin and dry mucous membranes, decreased bowel sounds and urinary retention in peripheral anticholinergic syndrome; and HALLUCINATIONS; PSYCHOSES; SEIZURES; and COMA in central anticholinergic syndrome.	""	0	#FFFFFF
D064927	C25.723.127.789|C26.176.793	Tick Bites	The effects, both local and systemic, caused by the bites of TICKS.	""	0	#FFFFFF
D065008	C25.723.127.142|C26.176.443	Scorpion Stings	The effects, both local and systemic, caused by the bite of SCORPIONS.	""	0	#FFFFFF
D065134	C17.300.451	Lipedema	Disorder of adipose tissue characterized by symmetric and bilateral enlargement of the lower extremities due to abnormal deposition of SUBCUTANEOUS FAT often in obese women. It is associated with HEMATOMA, pain and may progress to secondary LYMPHEDEMA which is known as lipolymphedema.	""	0	#FFFFFF
D065148	C17.800.174.600.693|C20.543.206.380.587|C25.100.468.380.693	Nicolau Syndrome	An uncommon complication of INTRAMUSCULAR INJECTION leading to variable degrees of necrosis of skin and underlying tissue.	""	0	#FFFFFF
D065166	C10.228.140.807	Sepsis-Associated Encephalopathy	Acute neurological dysfunction during severe SEPSIS in the absence of direct brain infection characterized by systemic inflammation and BLOOD BRAIN BARRIER perturbation.	""	0	#FFFFFF
D065167	C12.050.703.733.703.500	Pregnancy, Interstitial	A type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the portion of the FALLOPIAN TUBE that traverses the muscular wall of the uterus.	""	0	#FFFFFF
D065170	C12.050.703.733.619	Pregnancy, Angular	A rare type of abnormal pregnancy in which EMBRYO IMPLANTATION occurs at a lateral angle of the UTERUS, medial to the uterotubal junction and the ROUND LIGAMENT OF UTERUS.	""	0	#FFFFFF
D065172	C12.050.703.733.661	Pregnancy, Ovarian	A type of pregnancy in which EMBRYO IMPLANTATION occurs in an OVARY instead of in the uterine cavity.	""	0	#FFFFFF
D065173	C12.050.703.733.640	Pregnancy, Cornual	A type of pregnancy in which the EMBRYO IMPLANTATION occurs in the horn of the UTERUS instead of in the uterine cavity, i.e. at the junction of the uterus and one of the FALLOPIAN TUBES.	""	0	#FFFFFF
D065227	C15.378.962|C20.920	Transfusion Reaction	Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.	""	0	#FFFFFF
D065290	C06.552.308.500.750.249	Acute-On-Chronic Liver Failure	Sudden liver failure in the presence of underlying compensated chronic LIVER DISEASE (e.g., LIVER CIRRHOSIS; HEPATITIS; and liver injury and failure) due to a precipitating acute hepatic insult.	""	0	#FFFFFF
D065306	C10.900.300.284.250.124|C11.204.284|C11.297.374|C26.915.300.425.250.124	Corneal Injuries	Damage or trauma inflicted to the CORNEA by external means.	""	0	#FFFFFF
D065308	C23.149	Morphological and Microscopic Findings	Morphological findings useful in differentiation and classification of results in CYTODIAGNOSIS and related techniques.	""	0	#FFFFFF
D065309	C04.834.818.249|C12.050.351.500.852.593.074.249|C12.100.250.852.593.074.249|C23.149.500	Atypical Squamous Cells of the Cervix	Morphological abnormalities of the cervical EPITHELIUM, usually revealed in PAP SMEAR, which do not meet the criteria for squamous CERVICAL INTRAEPITHELIAL NEOPLASIA or SQUAMOUS CELL CARCINOMAS of the CERVIX . It may be a sign of infection with certain types of human papillomavirus (HPV).or sign of a benign (not cancer) growth, such as a cyst or polyp or, in menopausal women, of low hormone levels. More testing, such as HPV test, may be needed.	""	0	#FFFFFF
D065310	C04.834.818.500|C12.050.351.500.852.593.074.500|C12.100.250.852.593.074.500|C23.149.688.500	Squamous Intraepithelial Lesions of the Cervix	A cytological test finding often from PAP SMEARS that shows abnormal lesions of SQUAMOUS EPITHELIAL CELLS of the CERVIX. It is a diagnostic criterion used in the Bethesda System for UTERINE CERVICAL NEOPLASMS and represents the PAP TEST result that is abnormal. Although squamous intraepithelial lesions test result does not mean UTERINE CERVICAL NEOPLASMS it requires follow-ups (e.g., HPV DNA TESTS; and COLPOSCOPY).	""	0	#FFFFFF
D065311	C04.557.470.200.025.014|C04.557.470.200.240.124|C23.149.249	Adenocarcinoma in Situ	A lesion with cytological characteristics associated with invasive adenocarcinoma but the tumor cells are confined to the GLANDULAR EPITHELIAL CELLS of origin. Adenocarcinoma in situ of the CERVIX and the LUNG are the most common.	""	0	#FFFFFF
D065446	C23.550.568.968.500	Premenstrual Dysphoric Disorder	A condition in which a woman suffers from severe depression, irritability, and tension before MENSTRUATION. Premenstrual dysphoric disorder (PMDD) may involve a wide range of physical or emotional symptoms, which are more severe and debilitating than those seen with premenstrual syndrome (PMS), and which include at least one mood-related symptom. Symptoms usually stop when, or shortly after, menstruation begins.	""	0	#FFFFFF
D065606	C25.100.812	Metabolic Side Effects of Drugs and Substances	Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS.	""	0	#FFFFFF
D065626	C06.552.241.519	Non-alcoholic Fatty Liver Disease	Fatty liver finding without excessive ALCOHOL CONSUMPTION.	""	0	#FFFFFF
D065627	C08.381.423.300	Familial Primary Pulmonary Hypertension	Familial or idiopathic hypertension in the PULMONARY CIRCULATION which is not secondary to other disease.	""	0	#FFFFFF
D065630	C16.131.433|C23.300.707.960.500.116	Hernias, Diaphragmatic, Congenital	Protrusion of abdominal structures into the THORAX as a result of embryologic defects in the DIAPHRAGM often present in the neonatal period. It can be isolated, syndromic, non-syndromic or be a part of chromosome abnormality. Associated pulmonary hypoplasia and PULMONARY HYPERTENSION can further complicate stabilization and surgical intervention.	""	0	#FFFFFF
D065631	C08.460.799.315|C08.674.453|C09.603.799.315|C20.543.480.680.443	Rhinitis, Allergic	An inflammation of the NASAL MUCOSA triggered by ALLERGENS.	""	0	#FFFFFF
D065632	C01.920.500.078.184|C01.925.081.198|C01.925.782.930.100.184	Chikungunya Fever	An acute infection caused by a mosquito-borne alphavirus CHIKUNGUNYA VIRUS characterized by RASH; FEVER; JOINT PAINS; CONJUNCTIVITIS; MENINGOENCEPHALITIS; LYMPHOPENIA; and THROMBOCYTOPENIA.	""	0	#FFFFFF
D065634	C10.597.114|C10.900.300.109|C23.888.592.114|C26.915.300.225	Cerebrospinal Fluid Leak	Discharge of cerebrospinal fluid through a hole through the skull bone most commonly draining from the nose (CEREBROSPINAL FLUID RHINORRHEA) or the ear (CEREBROSPINAL FLUID OTORRHEA).	""	0	#FFFFFF
D065635	C09.218.568.900.883.500|C10.597.951.500|C23.888.592.958.500	Benign Paroxysmal Positional Vertigo	Idiopathic recurrent VERTIGO associated with POSITIONAL NYSTAGMUS. It is associated with a vestibular loss without other neurological or auditory signs. Unlike in LABYRINTHITIS and VESTIBULAR NEURONITIS, inflammation in the ear is not observed.	""	0	#FFFFFF
D065646	C04.557.470.200.725	Thyroid Carcinoma, Anaplastic	An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.	""	0	#FFFFFF
D065666	C06.405.469.656|C06.844.460|C14.907.549	Mesenteric Ischemia	Ischemic tissue injury produced by insufficient perfusion of intestinal tissue by the MESENTERIC CIRCULATION (i.e., CELIAC ARTERY; SUPERIOR MESENTERIC ARTERY; INFERERIOR MESENTERIC ARTERY; and MESENTERIC VEINS). It can progress from ISCHEMIA; EDEMA; and GANGRENE of the bowel wall to PERITONITIS and cardiovascular collapse.	""	0	#FFFFFF
D065703	C10.500.507.400|C16.131.666.507.400	Malformations of Cortical Development, Group I	Cortical malformations secondary to abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS in NEUROGENESIS. This group includes congenital MICROCEPHALIES; MICROLISSENCEPHALIES, megalencephalies, HEMIMEGALENCEPHALIES and cortical dysplasias with balloon cells.	""	0	#FFFFFF
D065704	C10.500.507.500|C16.131.666.507.500	Malformations of Cortical Development, Group III	Cortical malformations secondary to abnormal cortical maturation after CELL MIGRATION in NEUROGENESIS. This group includes injury to the cortex during later stages of cortical development such as POLYMICROGYRIA and focal cortical dysplasias.	""	0	#FFFFFF
D065705	C05.660.207.536.500|C10.500.507.400.249.500|C16.131.621.207.532.500|C16.131.666.507.400.249.500	Hemimegalencephaly	Rare MALFORMATIONS OF CORTICAL DEVELOPMENT, GROUP I characterized by the enlargement of one side of the brain. It is associated with seizures, partial paralysis, and mental retardation.	""	0	#FFFFFF
D065706	C10.500.507.500.500|C16.131.666.507.500.500	Polymicrogyria	Heterogeneous disorders of cortical malformation characterized by excessive and small fused gyri and shallow sulci of the CORTEX with abnormal cortical lamination. It is considered a malformation secondary to abnormal post-migrational development of the neurons during cerebral cortical development and is associated with EPILEPSY and learning difficulties.	""	0	#FFFFFF
D065707	C10.500.507.500.750|C16.131.666.507.500.750	Schizencephaly	Cortical malformations characterized by grey matter-lined cleft or cyst that extends from the EPENDYMA often to the PIA MATER outer surface. The grey matter that lines the cleft is often POLYMICROGYRIA. It is associated with developmental delay, motor disturbance and seizures.	""	0	#FFFFFF
D065708	C05.660.207.620.500|C10.500.507.500.625|C16.131.621.207.620.500|C16.131.666.507.500.625	Porencephaly	Cortical malformations characterized by white matter-lined cleft or cyst associated with ISCHEMIA and hemorrhagic insults. Symptoms include delayed growth and development, HYPOTONIA; SEIZURES; SPASTIC HEMIPLEGIA and MACROCEPHALY; MICROCEPHALY; or HYDROCEPHALUS. Mutations in the genes encoding COLLAGEN TYPE IV are associated with familial types.	""	0	#FFFFFF
D065710	C07.465.910.411	Glossoptosis	Posterior displacement of the TONGUE toward the PHARYNX. It is often a feature in syndromes such as in PIERRE ROBIN SYNDROME and DOWN SYNDROME and associated with AIRWAY OBSTRUCTION during sleep (OBSTRUCTIVE SLEEP APNEAS).	""	0	#FFFFFF
D065766	C12.050.351.968.419.936.463.500|C12.200.777.419.936.463.500|C12.950.419.936.463.500|C15.378.071.141.610.500|C15.378.140.855.925.500.500	Atypical Hemolytic Uremic Syndrome	An hereditary hemolytic uremic syndrome associated with variations in the gene that encodes COMPLEMENT FACTOR H, or the related proteins CFHR1 and CFHR3. Disease often progresses to CHRONIC KIDNEY FAILURE without the prodromal symptoms of ENTEROCOLITIS and DIARRHEA that characterize typical hemolytic uremic syndrome.	""	0	#FFFFFF
D065768	C10.228.140.490.493.750|C16.320.495	Lennox Gastaut Syndrome	A childhood-onset epilepsy syndrome.	""	0	#FFFFFF
D065817	C09.218.235|C16.131.287	Congenital Microtia	Malformation of external portion of EAR AURICLE.	""	0	#FFFFFF
D065906	C18.452.479|C23.888.516	Hyperlactatemia	Increase in blood LACTATE concentration often associated with SEPTIC SHOCK; LUNG INJURY; SEPSIS; and DRUG TOXICITY. When hyperlactatemia is associated with low body pH (acidosis) it is LACTIC ACIDOSIS.	""	0	#FFFFFF
D065907	C14.280.383.220.500|C23.550.260.322.250.500	Karoshi Death	Sudden death from overwork, most often as a result of acute CARDIOVASCULAR STROKE.	""	0	#FFFFFF
D066087	C12.050.703.572|C23.550.260.865	Perinatal Death	The death of a FETUS of GESTATIONAL AGE 28 weeks or more, or the death of a live-born INFANT less than 28 days of age.	""	0	#FFFFFF
D066088	C23.550.260.657	Infant Death	The death of a live-born INFANT within its first year of life.	""	0	#FFFFFF
D066126	C14.280.260|C23.550.161|C25.100.389|C26.733.266	Cardiotoxicity	Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	""	0	#FFFFFF
D066166	C05.116.099.739|C05.182.525|C05.660.745|C16.131.621.745|C17.300.182.525	Pectus Carinatum	A developmental anomaly characterized by abnormal anterior protrusion of the STERNUM and adjacent COSTAL CARTILAGE.	""	0	#FFFFFF
D066190	C10.597.606.762.175|C23.888.592.604.764.175	Allesthesia	A neurological disorder in which a sensory stimulus, usually tactile but more rarely other sensory modalities, is misperceived in a location distant from the original stimulus.	""	0	#FFFFFF
D066253	C23.300.977|C23.550.918	Vascular Remodeling	The active alterations of vascular wall structures, often leading to elevated VASCULAR RESISTANCE. It is associated with AGING; ATHEROSCLEROSIS; DIABETES MELLITUS; HYPERTENSION; PREGNANCY; PULMONARY HYPERTENSION; and STROKE, but is also a normal part of EMBRYOGENESIS.	""	0	#FFFFFF
D066263	C23.550.770	Protein Aggregation, Pathological	A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.	""	0	#FFFFFF