{ "cells": [ { "cell_type": "markdown", "metadata": {}, "source": [ "# PyOMADB Examples\n", "-- Alex Warwick Vesztrocy, December 2018\n", "\n", "This notebook shows the examples from the paper, as written by Klara Kaleb, using the Python library PyOMADB instead of the OMADB R package." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "The PyOMADB package can be installed from the PyPI -- as `omadb`. There are a few optional dependencies:\n", "- `dendropy` -- for dendropy trees\n", "- `ete3` -- for ETE tree visualisation\n", "- `goea` -- to perform GO enrichment analyses using GOATOOLS\n", "- `hog_analysis` -- to perform analysis on hierarchical orthologous groups (HOGs)" ] }, { "cell_type": "code", "execution_count": 1, "metadata": { "scrolled": true }, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "Collecting omadb\n", " Downloading https://files.pythonhosted.org/packages/60/d8/970f2718ece1c589fe3f8ed57a1666425ba61f8495e1b0496411bbb461db/omadb-1.0.14-py3-none-any.whl\n", "Requirement already satisfied: property-manager in /usr/local/miniconda3/lib/python3.6/site-packages (from omadb)\n", "Requirement already satisfied: pprint in /usr/local/miniconda3/lib/python3.6/site-packages (from omadb)\n", "Requirement already satisfied: tqdm in /usr/local/miniconda3/lib/python3.6/site-packages (from omadb)\n", "Requirement already satisfied: pandas in /usr/local/miniconda3/lib/python3.6/site-packages (from omadb)\n", "Requirement already satisfied: requests-cache in /usr/local/miniconda3/lib/python3.6/site-packages (from omadb)\n", "Requirement already satisfied: requests in /usr/local/miniconda3/lib/python3.6/site-packages (from omadb)\n", "Requirement already satisfied: appdirs in /usr/local/miniconda3/lib/python3.6/site-packages (from omadb)\n", "Requirement already satisfied: humanfriendly>=1.44.7 in /usr/local/miniconda3/lib/python3.6/site-packages (from property-manager->omadb)\n", "Requirement already satisfied: verboselogs>=1.1 in /usr/local/miniconda3/lib/python3.6/site-packages (from property-manager->omadb)\n", "Requirement already satisfied: python-dateutil>=2 in /usr/local/miniconda3/lib/python3.6/site-packages (from pandas->omadb)\n", "Requirement already satisfied: pytz>=2011k in /usr/local/miniconda3/lib/python3.6/site-packages (from pandas->omadb)\n", "Requirement already satisfied: numpy>=1.9.0 in /usr/local/miniconda3/lib/python3.6/site-packages (from pandas->omadb)\n", "Requirement already satisfied: chardet<3.1.0,>=3.0.2 in /usr/local/miniconda3/lib/python3.6/site-packages (from requests->omadb)\n", "Requirement already satisfied: idna<2.7,>=2.5 in /usr/local/miniconda3/lib/python3.6/site-packages (from requests->omadb)\n", "Requirement already satisfied: urllib3<1.23,>=1.21.1 in /usr/local/miniconda3/lib/python3.6/site-packages (from requests->omadb)\n", "Requirement already satisfied: certifi>=2017.4.17 in /usr/local/miniconda3/lib/python3.6/site-packages (from requests->omadb)\n", "Requirement already satisfied: six>=1.5 in /usr/local/miniconda3/lib/python3.6/site-packages (from python-dateutil>=2->pandas->omadb)\n", "Installing collected packages: omadb\n", "Successfully installed omadb-1.0.14\n", "\u001b[33mYou are using pip version 9.0.1, however version 18.1 is available.\n", "You should consider upgrading via the 'pip install --upgrade pip' command.\u001b[0m\n" ] } ], "source": [ "!pip install omadb[dendropy,ete3,goea]" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Now that the package is installed, we can load it." ] }, { "cell_type": "code", "execution_count": 2, "metadata": {}, "outputs": [], "source": [ "from omadb import Client" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Then the client can be initialised as such:" ] }, { "cell_type": "code", "execution_count": 3, "metadata": {}, "outputs": [], "source": [ "c = Client()" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Note: by default, the client will cache 10,000 `GET` requests in memory. If you wish to raise this, or lower it, this needs to be done prior to initialisation of the client by altering `Client.RAMCACHE_SIZE`." ] }, { "cell_type": "code", "execution_count": 4, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "10000" ] }, "execution_count": 4, "metadata": {}, "output_type": "execute_result" } ], "source": [ "Client.RAMCACHE_SIZE" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "---" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "## Example 1 -- Retrieving single protein entries" ] }, { "cell_type": "code", "execution_count": 5, "metadata": {}, "outputs": [], "source": [ "prot_id = 'P53_RAT'\n", "\n", "r = c.proteins[prot_id] # Can also be called as c.proteins.info(prot_id)" ] }, { "cell_type": "code", "execution_count": 6, "metadata": { "scrolled": true }, "outputs": [ { "data": { "text/plain": [ "{'alternative_isoforms_urls': [],\n", " 'canonicalid': 'P53_RAT',\n", " 'cdna': 'ATGGAGGATTCACAGTCGGATATGAGCATCGAGCTCCCTCTGAGTCAGGAGACATTTTCATGCTTATGGAAACTTCTTCCTCCAGATGATATTCTGCCCACCACAGCGACAGGGTCACCTAATTCCATGGAAGATCTGTTCCTGCCCCAGGATGTTGCAGAGTTGTTAGAAGGCCCAGAGGAAGCCCTCCAAGTGTCAGCTCCTGCAGCACAGGAACCTGGAACTGAGGCCCCTGCACCCGTGGCCCCTGCTTCAGCTACACCGTGGCCTCTGTCATCTTCCGTCCCTTCTCAAAAAACTTACCAAGGCAACTATGGCTTCCACCTGGGCTTCCTGCAGTCAGGGACAGCCAAGTCTGTTATGTGCACGTACTCAATTTCCCTCAATAAGCTGTTCTGCCAGCTGGCGAAGACATGCCCTGTGCAGTTGTGGGTCACCTCCACACCTCCACCTGGTACCCGTGTCCGTGCCATGGCCATCTACAAGAAGTCACAACACATGACTGAGGTCGTGAGACGCTGCCCCCACCATGAGCGTTGCTCTGATGGTGACGGCCTGGCTCCTCCCCAACATCTTATCCGGGTGGAAGGAAATCCGTATGCTGAGTATCTGGACGACAGGCAGACTTTTCGGCACAGCGTGGTGGTACCGTATGAGCCACCTGAGGTCGGCTCCGACTATACCACTATCCACTACAAGTACATGTGCAACAGCTCCTGCATGGGGGGCATGAACCGCCGGCCCATCCTTACCATCATCACGCTGGAAGACTCCAGTGGGAATCTTCTGGGACGGGACAGCTTTGAGGTTCGTGTTTGTGCCTGTCCTGGGAGAGACCGTCGGACAGAGGAAGAAAATTTCCGCAAAAAAGAAGAGCATTGCCCGGAGCTGCCCCCAGGGAGTGCAAAGAGAGCACTGCCCACCAGCACAAGCTCCTCTCCCCAGCAAAAGAAAAAACCACTCGATGGAGAATATTTCACCCTTAAGATCCGTGGGCGTGAGCGCTTCGAGATGTTCCGAGAGCTGAATGAGGCCTTGGAATTAAAGGATGCCCGTGCTGCCGAGGAGTCAGGAGACAGCAGGGCTCACTCCAGCTACCCGAAGACCAAGAAGGGCCAGTCTACGTCCCGCCATAAAAAACCAATGATCAAGAAAGTGGGGCCTGACTCAGACTGA',\n", " 'chromosome': '10',\n", " 'domains': ,\n", " 'entry_nr': 7916807,\n", " 'entry_url': ,\n", " 'hog_levels': ['Murinae',\n", " 'Muroidea',\n", " 'Myomorpha',\n", " 'Rodentia',\n", " 'Glires',\n", " 'Euarchontoglires',\n", " 'Boreoeutheria',\n", " 'Eutheria',\n", " 'Theria',\n", " 'Mammalia',\n", " 'Amniota',\n", " 'Tetrapoda',\n", " 'Sarcopterygii',\n", " 'Euteleostomi',\n", " 'Vertebrata',\n", " 'Chordata'],\n", " 'homoeologs': None,\n", " 'is_main_isoform': True,\n", " 'locus': {'end': 56198000, 'start': 56193866, 'strand': 1},\n", " 'oma_group': 789321,\n", " 'oma_group_url': ,\n", " 'oma_hog_id': 'HOG:0372238.2a.2a.2b',\n", " 'oma_hog_members': ,\n", " 'omaid': 'RATNO03710',\n", " 'ontology': ,\n", " 'orthologs': ,\n", " 'roothog_id': 372238,\n", " 'sequence': 'MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSPNSMEDLFLPQDVAELLEGPEEALQVSAPAAQEPGTEAPAPVAPASATPWPLSSSVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEEHCPELPPGSAKRALPTSTSSSPQQKKKPLDGEYFTLKIRGRERFEMFRELNEALELKDARAAEESGDSRAHSSYPKTKKGQSTSRHKKPMIKKVGPDSD',\n", " 'sequence_length': 391,\n", " 'sequence_md5': '6b5c5b7576ed037be819e56589e00c53',\n", " 'xref': }" ] }, "execution_count": 6, "metadata": {}, "output_type": "execute_result" } ], "source": [ "r" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "It is then possible to access any of the information on this protein entry, by using attribute or key retrieval. For example," ] }, { "cell_type": "code", "execution_count": 7, "metadata": { "scrolled": true }, "outputs": [ { "data": { "text/plain": [ "'ATGGAGGATTCACAGTCGGATATGAGCATCGAGCTCCCTCTGAGTCAGGAGACATTTTCATGCTTATGGAAACTTCTTCCTCCAGATGATATTCTGCCCACCACAGCGACAGGGTCACCTAATTCCATGGAAGATCTGTTCCTGCCCCAGGATGTTGCAGAGTTGTTAGAAGGCCCAGAGGAAGCCCTCCAAGTGTCAGCTCCTGCAGCACAGGAACCTGGAACTGAGGCCCCTGCACCCGTGGCCCCTGCTTCAGCTACACCGTGGCCTCTGTCATCTTCCGTCCCTTCTCAAAAAACTTACCAAGGCAACTATGGCTTCCACCTGGGCTTCCTGCAGTCAGGGACAGCCAAGTCTGTTATGTGCACGTACTCAATTTCCCTCAATAAGCTGTTCTGCCAGCTGGCGAAGACATGCCCTGTGCAGTTGTGGGTCACCTCCACACCTCCACCTGGTACCCGTGTCCGTGCCATGGCCATCTACAAGAAGTCACAACACATGACTGAGGTCGTGAGACGCTGCCCCCACCATGAGCGTTGCTCTGATGGTGACGGCCTGGCTCCTCCCCAACATCTTATCCGGGTGGAAGGAAATCCGTATGCTGAGTATCTGGACGACAGGCAGACTTTTCGGCACAGCGTGGTGGTACCGTATGAGCCACCTGAGGTCGGCTCCGACTATACCACTATCCACTACAAGTACATGTGCAACAGCTCCTGCATGGGGGGCATGAACCGCCGGCCCATCCTTACCATCATCACGCTGGAAGACTCCAGTGGGAATCTTCTGGGACGGGACAGCTTTGAGGTTCGTGTTTGTGCCTGTCCTGGGAGAGACCGTCGGACAGAGGAAGAAAATTTCCGCAAAAAAGAAGAGCATTGCCCGGAGCTGCCCCCAGGGAGTGCAAAGAGAGCACTGCCCACCAGCACAAGCTCCTCTCCCCAGCAAAAGAAAAAACCACTCGATGGAGAATATTTCACCCTTAAGATCCGTGGGCGTGAGCGCTTCGAGATGTTCCGAGAGCTGAATGAGGCCTTGGAATTAAAGGATGCCCGTGCTGCCGAGGAGTCAGGAGACAGCAGGGCTCACTCCAGCTACCCGAAGACCAAGAAGGGCCAGTCTACGTCCCGCCATAAAAAACCAATGATCAAGAAAGTGGGGCCTGACTCAGACTGA'" ] }, "execution_count": 7, "metadata": {}, "output_type": "execute_result" } ], "source": [ "r.cdna" ] }, { "cell_type": "code", "execution_count": 8, "metadata": { "scrolled": true }, "outputs": [ { "data": { "text/plain": [ "'ATGGAGGATTCACAGTCGGATATGAGCATCGAGCTCCCTCTGAGTCAGGAGACATTTTCATGCTTATGGAAACTTCTTCCTCCAGATGATATTCTGCCCACCACAGCGACAGGGTCACCTAATTCCATGGAAGATCTGTTCCTGCCCCAGGATGTTGCAGAGTTGTTAGAAGGCCCAGAGGAAGCCCTCCAAGTGTCAGCTCCTGCAGCACAGGAACCTGGAACTGAGGCCCCTGCACCCGTGGCCCCTGCTTCAGCTACACCGTGGCCTCTGTCATCTTCCGTCCCTTCTCAAAAAACTTACCAAGGCAACTATGGCTTCCACCTGGGCTTCCTGCAGTCAGGGACAGCCAAGTCTGTTATGTGCACGTACTCAATTTCCCTCAATAAGCTGTTCTGCCAGCTGGCGAAGACATGCCCTGTGCAGTTGTGGGTCACCTCCACACCTCCACCTGGTACCCGTGTCCGTGCCATGGCCATCTACAAGAAGTCACAACACATGACTGAGGTCGTGAGACGCTGCCCCCACCATGAGCGTTGCTCTGATGGTGACGGCCTGGCTCCTCCCCAACATCTTATCCGGGTGGAAGGAAATCCGTATGCTGAGTATCTGGACGACAGGCAGACTTTTCGGCACAGCGTGGTGGTACCGTATGAGCCACCTGAGGTCGGCTCCGACTATACCACTATCCACTACAAGTACATGTGCAACAGCTCCTGCATGGGGGGCATGAACCGCCGGCCCATCCTTACCATCATCACGCTGGAAGACTCCAGTGGGAATCTTCTGGGACGGGACAGCTTTGAGGTTCGTGTTTGTGCCTGTCCTGGGAGAGACCGTCGGACAGAGGAAGAAAATTTCCGCAAAAAAGAAGAGCATTGCCCGGAGCTGCCCCCAGGGAGTGCAAAGAGAGCACTGCCCACCAGCACAAGCTCCTCTCCCCAGCAAAAGAAAAAACCACTCGATGGAGAATATTTCACCCTTAAGATCCGTGGGCGTGAGCGCTTCGAGATGTTCCGAGAGCTGAATGAGGCCTTGGAATTAAAGGATGCCCGTGCTGCCGAGGAGTCAGGAGACAGCAGGGCTCACTCCAGCTACCCGAAGACCAAGAAGGGCCAGTCTACGTCCCGCCATAAAAAACCAATGATCAAGAAAGTGGGGCCTGACTCAGACTGA'" ] }, "execution_count": 8, "metadata": {}, "output_type": "execute_result" } ], "source": [ "r['cdna']" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Information that requires another load from the database shows up as \"``\" in the representation of the result, above. If using dictionary-style access, these need to be called. For example, when accessing the orthologue information:" ] }, { "cell_type": "code", "execution_count": 9, "metadata": {}, "outputs": [], "source": [ "orth = r['orthologs']()" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "However, if accessing via attributes this is lazily loaded in the background:" ] }, { "cell_type": "code", "execution_count": 10, "metadata": {}, "outputs": [], "source": [ "orth = r.orthologs" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "---" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "## Example 2 -- Sequence to HOG, to HOG Members, to GO Annotations" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "The idea here is to find a HOG for a given protein sequence, through the mapping procedure provided by the OMA REST API. If we start with the following sequence," ] }, { "cell_type": "code", "execution_count": 11, "metadata": {}, "outputs": [], "source": [ "seq = 'MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK'" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "It is possible to map this to the an OMA protein entry using:" ] }, { "cell_type": "code", "execution_count": 12, "metadata": {}, "outputs": [], "source": [ "r = c.proteins.search(seq)" ] }, { "cell_type": "code", "execution_count": 13, "metadata": { "scrolled": true }, "outputs": [ { "data": { "text/plain": [ "{'identified_by': 'exact match',\n", " 'query': 'MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK',\n", " 'targets': [{'alternative_isoforms_urls': [],\n", " 'canonicalid': 'TRFL_HUMAN',\n", " 'cdna': 'ATGAAACTTGTCTTCCTCGTCCTGCTGTTCCTCGGGGCCCTCGGACTGTGTCTGGCTGGCCGTAGGAGGAGTGTTCAGTGGTGCGCCGTATCCCAACCCGAGGCCACAAAATGCTTCCAATGGCAAAGGAATATGAGAAAAGTGCGTGGCCCTCCTGTCAGCTGCATAAAGAGAGACTCCCCCATCCAGTGTATCCAGGCCATTGCGGAAAACAGGGCCGATGCTGTGACCCTTGATGGTGGTTTCATATACGAGGCAGGCCTGGCCCCCTACAAACTGCGACCTGTAGCGGCGGAAGTCTACGGGACCGAAAGACAGCCACGAACTCACTATTATGCCGTGGCTGTGGTGAAGAAGGGCGGCAGCTTTCAGCTGAACGAACTGCAAGGTCTGAAGTCCTGCCACACAGGCCTTCGCAGGACCGCTGGATGGAATGTCCCTATAGGGACACTTCGTCCATTCTTGAATTGGACGGGTCCACCTGAGCCCATTGAGGCAGCTGTGGCCAGGTTCTTCTCAGCCAGCTGTGTTCCCGGTGCAGATAAAGGACAGTTCCCCAACCTGTGTCGCCTGTGTGCGGGGACAGGGGAAAACAAATGTGCCTTCTCCTCCCAGGAACCGTACTTCAGCTACTCTGGTGCCTTCAAGTGTCTGAGAGACGGGGCTGGAGACGTGGCTTTTATCAGAGAGAGCACAGTGTTTGAGGACCTGTCAGACGAGGCTGAAAGGGACGAGTATGAGTTACTCTGCCCAGACAACACTCGGAAGCCAGTGGACAAGTTCAAAGACTGCCATCTGGCCCGGGTCCCTTCTCATGCCGTTGTGGCACGAAGTGTGAATGGCAAGGAGGATGCCATCTGGAATCTTCTCCGCCAGGCACAGGAAAAGTTTGGAAAGGACAAGTCACCGAAATTCCAGCTCTTTGGCTCCCCTAGTGGGCAGAAAGATCTGCTGTTCAAGGACTCTGCCATTGGGTTTTCGAGGGTGCCCCCGAGGATAGATTCTGGGCTGTACCTTGGCTCCGGCTACTTCACTGCCATCCAGAACTTGAGGAAAAGTGAGGAGGAAGTGGCTGCCCGGCGTGCGCGGGTCGTGTGGTGTGCGGTGGGCGAGCAGGAGCTGCGCAAGTGTAACCAGTGGAGTGGCTTGAGCGAAGGCAGCGTGACCTGCTCCTCGGCCTCCACCACAGAGGACTGCATCGCCCTGGTGCTGAAAGGAGAAGCTGATGCCATGAGTTTGGATGGAGGATATGTGTACACTGCAGGCAAATGTGGTTTGGTGCCTGTCCTGGCAGAGAACTACAAATCCCAACAAAGCAGTGACCCTGATCCTAACTGTGTGGATAGACCTGTGGAAGGATATCTTGCTGTGGCGGTGGTTAGGAGATCAGACACTAGCCTTACCTGGAACTCTGTGAAAGGCAAGAAGTCCTGCCACACCGCCGTGGACAGGACTGCAGGCTGGAATATCCCCATGGGCCTGCTCTTCAACCAGACGGGCTCCTGCAAATTTGATGAATATTTCAGTCAAAGCTGTGCCCCTGGGTCTGACCCGAGATCTAATCTCTGTGCTCTGTGTATTGGCGACGAGCAGGGTGAGAATAAGTGCGTGCCCAACAGCAACGAGAGATACTACGGCTACACTGGGGCTTTCCGGTGCCTGGCTGAGAATGCTGGAGACGTTGCATTTGTGAAAGATGTCACTGTCTTGCAGAACACTGATGGAAATAACAATGAGGCATGGGCTAAGGATTTGAAGCTGGCAGACTTTGCGCTGCTGTGCCTCGATGGCAAACGGAAGCCTGTGACTGAGGCTAGAAGCTGCCATCTTGCCATGGCCCCGAATCATGCCGTGGTGTCTCGGATGGATAAGGTGGAACGCCTGAAACAGGTGTTGCTCCACCAACAGGCTAAATTTGGGAGAAATGGATCTGACTGCCCGGACAAGTTTTGCTTATTCCAGTCTGAAACCAAAAACCTTCTGTTCAATGACAACACTGAGTGTCTGGCCAGACTCCATGGCAAAACAACATATGAAAAATATTTGGGACCACAGTATGTCGCAGGCATTACTAATCTGAAAAAGTGCTCAACCTCCCCCCTCCTGGAAGCCTGTGAATTCCTCAGGAAGTAA',\n", " 'chromosome': '3',\n", " 'domains': ,\n", " 'entry_nr': 8087255,\n", " 'entry_url': ,\n", " 'hog_levels': ['Homininae',\n", " 'Hominidae',\n", " 'Hominoidea',\n", " 'Catarrhini',\n", " 'Simiiformes',\n", " 'Haplorrhini',\n", " 'Primates',\n", " 'Euarchontoglires',\n", " 'Boreoeutheria',\n", " 'Eutheria',\n", " 'Theria',\n", " 'Mammalia',\n", " 'Amniota',\n", " 'Tetrapoda',\n", " 'Sarcopterygii',\n", " 'Euteleostomi',\n", " 'Vertebrata',\n", " 'Chordata',\n", " 'Deuterostomia',\n", " 'Bilateria',\n", " 'Eumetazoa',\n", " 'Metazoa',\n", " 'Opisthokonta',\n", " 'Eukaryota'],\n", " 'homoeologs': None,\n", " 'is_main_isoform': True,\n", " 'locus': {'end': 46464867, 'start': 46436195, 'strand': -1},\n", " 'oma_group': 827039,\n", " 'oma_group_url': ,\n", " 'oma_hog_id': 'HOG:0413862.1a.1b',\n", " 'oma_hog_members': ,\n", " 'omaid': 'HUMAN20795',\n", " 'ontology': ,\n", " 'orthologs': ,\n", " 'roothog_id': 413862,\n", " 'sequence': 'MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK',\n", " 'sequence_length': 710,\n", " 'sequence_md5': '49350ec6dd02aabc8eb8cabc10476a4f',\n", " 'xref': }]}" ] }, "execution_count": 13, "metadata": {}, "output_type": "execute_result" } ], "source": [ "r" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "From the results above, we can see that the matches were identified as _exact_ matches. This means that they are 100% identical to the query sequence.\n", "\n", "Now, let's see how many targets we have matched:" ] }, { "cell_type": "code", "execution_count": 14, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "1" ] }, "execution_count": 14, "metadata": {}, "output_type": "execute_result" } ], "source": [ "len(r.targets)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Here we have matched a single target. Let's find its OMA ID, canonical ID and the HOG that it belongs to." ] }, { "cell_type": "code", "execution_count": 15, "metadata": {}, "outputs": [], "source": [ "e = r.targets[0]" ] }, { "cell_type": "code", "execution_count": 16, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "'HUMAN20795'" ] }, "execution_count": 16, "metadata": {}, "output_type": "execute_result" } ], "source": [ "e.omaid" ] }, { "cell_type": "code", "execution_count": 17, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "'TRFL_HUMAN'" ] }, "execution_count": 17, "metadata": {}, "output_type": "execute_result" } ], "source": [ "e.canonicalid" ] }, { "cell_type": "code", "execution_count": 18, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "'HOG:0413862.1a.1b'" ] }, "execution_count": 18, "metadata": {}, "output_type": "execute_result" } ], "source": [ "e.oma_hog_id" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Next, we want to access all members from this HOG. This can be done in two ways." ] }, { "cell_type": "code", "execution_count": 19, "metadata": {}, "outputs": [], "source": [ "hog = e.oma_hog_members\n", "hog_members = hog.members\n", "\n", "# Alternative:\n", "hog_members = c.hogs.members(e.oma_hog_id)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "We can then see which level this HOG is at, by accessing:" ] }, { "cell_type": "code", "execution_count": 20, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "'Mammalia'" ] }, "execution_count": 20, "metadata": {}, "output_type": "execute_result" } ], "source": [ "hog.level" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Note, it is also possible to go directly to the HOG members from a protein entry as well as a HOG ID." ] }, { "cell_type": "code", "execution_count": 21, "metadata": {}, "outputs": [], "source": [ "hog_members = c.hogs.members('TRFL_HUMAN')" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Finally, let's find the GO annotations for the members of this HOG at the _Eukaryota_ level. We can then perform a GO enrichment analysis (GOEA) in order to see if this group, at the _Mammalia_ level, is enriched in any particular GO terms.\n", "\n", "This defines our background set of genes in our GOEA.\n", "\n", "We can use the GOATOOLs library to perform this analysis. There is handy functionality in the PyOMADB library to load this automatically for us -- it can even filter to a desired aspect of the GO." ] }, { "cell_type": "code", "execution_count": 22, "metadata": {}, "outputs": [ { "name": "stderr", "output_type": "stream", "text": [ "Retrieving GO: 100%|██████████| 263/263 [00:38<00:00, 6.75it/s]\n" ] }, { "name": "stdout", "output_type": "stream", "text": [ "/var/folders/h9/3pbgfw_n4r53rndnhmrgn3lh0000gn/T/tmp5o_aywsx.obo: fmt(1.2) rel(2018-12-18) 47,369 GO Terms\n", "fisher module not installed. Falling back on scipy.stats.fisher_exact\n", "100% 263 of 263 population items found in association\n" ] }, { "name": "stderr", "output_type": "stream", "text": [ "Propagating term counts to parents ..\n" ] } ], "source": [ "euk_hog_members = c.hogs.members('TRFL_HUMAN', level='Eukaryota')\n", "\n", "background = [e.omaid for e in euk_hog_members]\n", "\n", "goea = c.entries.gene_ontology(background, # Background list of IDs\n", " aspect='BP', # Filtering (optional)\n", " as_goatools=True, # To return GOATOOLS GOEA object\n", " progress=True, # Show progress of GO retrieval\n", " methods=['fdr_bh']) # Passed to GOATOOLS (methods for GOEA) " ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Our foreground set is then the genes that are defined in the HOG at the level of _Mammalia_." ] }, { "cell_type": "code", "execution_count": 23, "metadata": {}, "outputs": [], "source": [ "foreground = [e.omaid for e in hog_members]" ] }, { "cell_type": "code", "execution_count": 24, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "100% 40 of 40 study items found in association\n", "100% 40 of 40 study items found in population(263)\n", "Calculating 421 uncorrected p-values using fisher_scipy_stats\n", " 421 GO terms are associated with 227 of 263 population items\n", " 272 GO terms are associated with 39 of 40 study items\n", " 280 GO terms found significant (< 0.05=alpha) after multitest correction: statsmodels fdr_bh\n" ] } ], "source": [ "results = goea.run_study(foreground)" ] }, { "cell_type": "code", "execution_count": 25, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "GO\tNS\tenrichment\tname\tratio_in_study\tratio_in_pop\tp_uncorrected\tdepth\tstudy_count\tp_fdr_bh\tstudy_items\n", "GO:1900228\tBP\te\tregulation of single-species biofilm formation in or on host organism\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043900\tBP\te\tregulation of multi-organism process\t39/40\t39/263\t6.63e-46\t3\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0032101\tBP\te\tregulation of response to external stimulus\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1903011\tBP\te\tnegative regulation of bone development\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002682\tBP\te\tregulation of immune system process\t39/40\t39/263\t6.63e-46\t3\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0030501\tBP\te\tpositive regulation of bone mineralization\t39/40\t39/263\t6.63e-46\t7\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1902105\tBP\te\tregulation of leukocyte differentiation\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002831\tBP\te\tregulation of response to biotic stimulus\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1900157\tBP\te\tregulation of bone mineralization involved in bone maturation\t39/40\t39/263\t6.63e-46\t7\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043903\tBP\te\tregulation of symbiosis, encompassing mutualism through parasitism\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002832\tBP\te\tnegative regulation of response to biotic stimulus\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1903012\tBP\te\tpositive regulation of bone development\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045667\tBP\te\tregulation of osteoblast differentiation\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045670\tBP\te\tregulation of osteoclast differentiation\t39/40\t39/263\t6.63e-46\t8\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0031665\tBP\te\tnegative regulation of lipopolysaccharide-mediated signaling pathway\t39/40\t39/263\t6.63e-46\t7\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1903010\tBP\te\tregulation of bone development\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:2001204\tBP\te\tregulation of osteoclast development\t39/40\t39/263\t6.63e-46\t9\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0032102\tBP\te\tnegative regulation of response to external stimulus\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0032501\tBP\te\tmulticellular organismal process\t39/40\t39/263\t6.63e-46\t1\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0030278\tBP\te\tregulation of ossification \t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0060349\tBP\te\tbone morphogenesis \t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0070167\tBP\te\tregulation of biomineral tissue development\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0001818\tBP\te\tnegative regulation of cytokine production\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0032680\tBP\te\tregulation of tumor necrosis factor production\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0001817\tBP\te\tregulation of cytokine production\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002683\tBP\te\tnegative regulation of immune system process\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045669\tBP\te\tpositive regulation of osteoblast differentiation\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0001503\tBP\te\tossification \t39/40\t39/263\t6.63e-46\t2\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045778\tBP\te\tpositive regulation of ossification\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0031664\tBP\te\tregulation of lipopolysaccharide-mediated signaling pathway\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045637\tBP\te\tregulation of myeloid cell differentiation\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1900229\tBP\te\tnegative regulation of single-species biofilm formation in or on host organism\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0033688\tBP\te\tregulation of osteoblast proliferation\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002761\tBP\te\tregulation of myeloid leukocyte differentiation\t39/40\t39/263\t6.63e-46\t7\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:2000308\tBP\te\tnegative regulation of tumor necrosis factor (ligand) superfamily member 11 production\t39/40\t39/263\t6.63e-46\t7\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0030500\tBP\te\tregulation of bone mineralization\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1900159\tBP\te\tpositive regulation of bone mineralization involved in bone maturation\t39/40\t39/263\t6.63e-46\t8\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1900190\tBP\te\tregulation of single-species biofilm formation\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1903556\tBP\te\tnegative regulation of tumor necrosis factor superfamily cytokine production\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:2000307\tBP\te\tregulation of tumor necrosis factor (ligand) superfamily member 11 production\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1903707\tBP\te\tnegative regulation of hemopoiesis\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1900191\tBP\te\tnegative regulation of single-species biofilm formation\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1902106\tBP\te\tnegative regulation of leukocyte differentiation\t39/40\t39/263\t6.63e-46\t7\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1902732\tBP\te\tpositive regulation of chondrocyte proliferation\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043901\tBP\te\tnegative regulation of multi-organism process\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002762\tBP\te\tnegative regulation of myeloid leukocyte differentiation\t39/40\t39/263\t6.63e-46\t8\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051241\tBP\te\tnegative regulation of multicellular organismal process\t39/40\t39/263\t6.63e-46\t4\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:2001205\tBP\te\tnegative regulation of osteoclast development\t39/40\t39/263\t6.63e-46\t10\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1903706\tBP\te\tregulation of hemopoiesis \t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045638\tBP\te\tnegative regulation of myeloid cell differentiation\t39/40\t39/263\t6.63e-46\t7\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0033690\tBP\te\tpositive regulation of osteoblast proliferation\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1903555\tBP\te\tregulation of tumor necrosis factor superfamily cytokine production\t39/40\t39/263\t6.63e-46\t5\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045671\tBP\te\tnegative regulation of osteoclast differentiation\t39/40\t39/263\t6.63e-46\t9\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0070169\tBP\te\tpositive regulation of biomineral tissue development\t39/40\t39/263\t6.63e-46\t6\t39\t5.17e-45\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006952\tBP\te\tdefense response \t39/40\t40/263\t2.64e-44\t3\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0019730\tBP\te\tantimicrobial humoral response\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002251\tBP\te\torgan or tissue specific immune response\t39/40\t40/263\t2.64e-44\t3\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0060548\tBP\te\tnegative regulation of cell death\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0010941\tBP\te\tregulation of cell death \t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043067\tBP\te\tregulation of programmed cell death\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0048585\tBP\te\tnegative regulation of response to stimulus\t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:2000116\tBP\te\tregulation of cysteine-type endopeptidase activity\t39/40\t40/263\t2.64e-44\t9\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006959\tBP\te\thumoral immune response \t39/40\t40/263\t2.64e-44\t3\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009887\tBP\te\tanimal organ morphogenesis \t39/40\t40/263\t2.64e-44\t3\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0019731\tBP\te\tantibacterial humoral response\t39/40\t40/263\t2.64e-44\t7\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0031324\tBP\te\tnegative regulation of cellular metabolic process\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0032269\tBP\te\tnegative regulation of cellular protein metabolic process\t39/40\t40/263\t2.64e-44\t7\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002376\tBP\te\timmune system process \t39/40\t40/263\t2.64e-44\t1\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0052547\tBP\te\tregulation of peptidase activity\t39/40\t40/263\t2.64e-44\t7\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0052548\tBP\te\tregulation of endopeptidase activity\t39/40\t40/263\t2.64e-44\t8\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009620\tBP\te\tresponse to fungus \t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045087\tBP\te\tinnate immune response \t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051094\tBP\te\tpositive regulation of developmental process\t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0050832\tBP\te\tdefense response to fungus \t39/40\t40/263\t2.64e-44\t6\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0023057\tBP\te\tnegative regulation of signaling\t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:2000117\tBP\te\tnegative regulation of cysteine-type endopeptidase activity\t39/40\t40/263\t2.64e-44\t11\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002227\tBP\te\tinnate immune response in mucosa\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051239\tBP\te\tregulation of multicellular organismal process\t39/40\t40/263\t2.64e-44\t3\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051346\tBP\te\tnegative regulation of hydrolase activity\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006955\tBP\te\timmune response \t39/40\t40/263\t2.64e-44\t2\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:2000026\tBP\te\tregulation of multicellular organismal development\t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0098542\tBP\te\tdefense response to other organism\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009892\tBP\te\tnegative regulation of metabolic process\t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0010648\tBP\te\tnegative regulation of cell communication\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051336\tBP\te\tregulation of hydrolase activity\t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045597\tBP\te\tpositive regulation of cell differentiation\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006508\tBP\te\tproteolysis \t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0042742\tBP\te\tdefense response to bacterium \t39/40\t40/263\t2.64e-44\t6\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0010466\tBP\te\tnegative regulation of peptidase activity\t39/40\t40/263\t2.64e-44\t9\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0002385\tBP\te\tmucosal immune response \t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043069\tBP\te\tnegative regulation of programmed cell death\t39/40\t40/263\t2.64e-44\t6\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0019732\tBP\te\tantifungal humoral response \t39/40\t40/263\t2.64e-44\t7\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009968\tBP\te\tnegative regulation of signal transduction\t39/40\t40/263\t2.64e-44\t6\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045861\tBP\te\tnegative regulation of proteolysis\t39/40\t40/263\t2.64e-44\t8\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0042981\tBP\te\tregulation of apoptotic process\t39/40\t40/263\t2.64e-44\t6\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0010951\tBP\te\tnegative regulation of endopeptidase activity\t39/40\t40/263\t2.64e-44\t10\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051248\tBP\te\tnegative regulation of protein metabolic process\t39/40\t40/263\t2.64e-44\t6\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043066\tBP\te\tnegative regulation of apoptotic process\t39/40\t40/263\t2.64e-44\t7\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009653\tBP\te\tanatomical structure morphogenesis\t39/40\t40/263\t2.64e-44\t2\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051240\tBP\te\tpositive regulation of multicellular organismal process\t39/40\t40/263\t2.64e-44\t4\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0010605\tBP\te\tnegative regulation of macromolecule metabolic process\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051172\tBP\te\tnegative regulation of nitrogen compound metabolic process\t39/40\t40/263\t2.64e-44\t5\t39\t1.09e-43\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0032502\tBP\te\tdevelopmental process \t39/40\t41/263\t5.39e-43\t1\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0010646\tBP\te\tregulation of cell communication\t39/40\t41/263\t5.39e-43\t4\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0048583\tBP\te\tregulation of response to stimulus\t39/40\t41/263\t5.39e-43\t3\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009966\tBP\te\tregulation of signal transduction\t39/40\t41/263\t5.39e-43\t5\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006950\tBP\te\tresponse to stress \t39/40\t41/263\t5.39e-43\t2\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0008284\tBP\te\tpositive regulation of cell population proliferation\t39/40\t41/263\t5.39e-43\t5\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0042127\tBP\te\tregulation of cell population proliferation\t39/40\t41/263\t5.39e-43\t4\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0023051\tBP\te\tregulation of signaling \t39/40\t41/263\t5.39e-43\t3\t39\t2.06e-42\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009605\tBP\te\tresponse to external stimulus \t39/40\t49/263\t5.21e-36\t2\t39\t1.89e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043207\tBP\te\tresponse to external biotic stimulus\t39/40\t49/263\t5.21e-36\t3\t39\t1.89e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009607\tBP\te\tresponse to biotic stimulus \t39/40\t49/263\t5.21e-36\t2\t39\t1.89e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051707\tBP\te\tresponse to other organism \t39/40\t49/263\t5.21e-36\t4\t39\t1.89e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0009617\tBP\te\tresponse to bacterium \t39/40\t49/263\t5.21e-36\t5\t39\t1.89e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051704\tBP\te\tmulti-organism process \t39/40\t49/263\t5.21e-36\t1\t39\t1.89e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0019538\tBP\te\tprotein metabolic process \t39/40\t50/263\t2.36e-35\t4\t39\t8.14e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043170\tBP\te\tmacromolecule metabolic process\t39/40\t50/263\t2.36e-35\t3\t39\t8.14e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:1901564\tBP\te\torganonitrogen compound metabolic process\t39/40\t50/263\t2.36e-35\t3\t39\t8.14e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0071704\tBP\te\torganic substance metabolic process\t39/40\t50/263\t2.36e-35\t2\t39\t8.14e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006807\tBP\te\tnitrogen compound metabolic process\t39/40\t50/263\t2.36e-35\t2\t39\t8.14e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0044238\tBP\te\tprimary metabolic process \t39/40\t50/263\t2.36e-35\t2\t39\t8.14e-35\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0008152\tBP\te\tmetabolic process \t39/40\t51/263\t9.98e-35\t1\t39\t3.41e-34\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0044092\tBP\te\tnegative regulation of molecular function\t39/40\t60/263\t4.81e-30\t3\t39\t1.62e-29\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0043086\tBP\te\tnegative regulation of catalytic activity\t39/40\t60/263\t4.81e-30\t4\t39\t1.62e-29\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0065009\tBP\te\tregulation of molecular function\t39/40\t61/263\t1.33e-29\t2\t39\t4.4e-29\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0050790\tBP\te\tregulation of catalytic activity\t39/40\t61/263\t1.33e-29\t3\t39\t4.4e-29\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0050896\tBP\te\tresponse to stimulus \t39/40\t65/263\t5.89e-28\t1\t39\t1.94e-27\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0010721\tBP\te\tnegative regulation of cell development\t39/40\t66/263\t1.43e-27\t6\t39\t4.68e-27\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051093\tBP\te\tnegative regulation of developmental process\t39/40\t67/263\t3.41e-27\t4\t39\t1.06e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0030162\tBP\te\tregulation of proteolysis \t39/40\t67/263\t3.41e-27\t6\t39\t1.06e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0060284\tBP\te\tregulation of cell development\t39/40\t67/263\t3.41e-27\t5\t39\t1.06e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0048523\tBP\te\tnegative regulation of cellular process\t39/40\t67/263\t3.41e-27\t4\t39\t1.06e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045596\tBP\te\tnegative regulation of cell differentiation\t39/40\t67/263\t3.41e-27\t5\t39\t1.06e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0048519\tBP\te\tnegative regulation of biological process\t39/40\t67/263\t3.41e-27\t3\t39\t1.06e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0060255\tBP\te\tregulation of macromolecule metabolic process\t39/40\t68/263\t7.97e-27\t4\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0032268\tBP\te\tregulation of cellular protein metabolic process\t39/40\t68/263\t7.97e-27\t6\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0031323\tBP\te\tregulation of cellular metabolic process\t39/40\t68/263\t7.97e-27\t4\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0050793\tBP\te\tregulation of developmental process\t39/40\t68/263\t7.97e-27\t3\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0080090\tBP\te\tregulation of primary metabolic process\t39/40\t68/263\t7.97e-27\t4\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051246\tBP\te\tregulation of protein metabolic process\t39/40\t68/263\t7.97e-27\t5\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0045595\tBP\te\tregulation of cell differentiation\t39/40\t68/263\t7.97e-27\t4\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051171\tBP\te\tregulation of nitrogen compound metabolic process\t39/40\t68/263\t7.97e-27\t4\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0019222\tBP\te\tregulation of metabolic process\t39/40\t68/263\t7.97e-27\t3\t39\t2.33e-26\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0048518\tBP\te\tpositive regulation of biological process\t39/40\t82/263\t2.08e-22\t3\t39\t5.91e-22\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0050789\tBP\te\tregulation of biological process\t39/40\t82/263\t2.08e-22\t2\t39\t5.91e-22\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0050794\tBP\te\tregulation of cellular process\t39/40\t82/263\t2.08e-22\t3\t39\t5.91e-22\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0048522\tBP\te\tpositive regulation of cellular process\t39/40\t82/263\t2.08e-22\t4\t39\t5.91e-22\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0031640\tBP\te\tkilling of cells of other organism\t20/40\t20/263\t2.81e-19\t5\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0050778\tBP\te\tpositive regulation of immune response\t20/40\t20/263\t2.81e-19\t5\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0031349\tBP\te\tpositive regulation of defense response\t20/40\t20/263\t2.81e-19\t6\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:1903900\tBP\te\tregulation of viral life cycle\t20/40\t20/263\t2.81e-19\t6\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0034121\tBP\te\tregulation of toll-like receptor signaling pathway\t20/40\t20/263\t2.81e-19\t7\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:1903901\tBP\te\tnegative regulation of viral life cycle\t20/40\t20/263\t2.81e-19\t7\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0050829\tBP\te\tdefense response to Gram-negative bacterium\t20/40\t20/263\t2.81e-19\t7\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0045088\tBP\te\tregulation of innate immune response\t20/40\t20/263\t2.81e-19\t6\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051092\tBP\te\tpositive regulation of NF-kappaB transcription factor activity\t20/40\t20/263\t2.81e-19\t12\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0034143\tBP\te\tregulation of toll-like receptor 4 signaling pathway\t20/40\t20/263\t2.81e-19\t8\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051673\tBP\te\tmembrane disruption in other organism\t20/40\t20/263\t2.81e-19\t4\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0043122\tBP\te\tregulation of I-kappaB kinase/NF-kappaB signaling\t20/40\t20/263\t2.81e-19\t7\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0043462\tBP\te\tregulation of ATPase activity \t20/40\t20/263\t2.81e-19\t5\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0043123\tBP\te\tpositive regulation of I-kappaB kinase/NF-kappaB signaling\t20/40\t20/263\t2.81e-19\t8\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0045069\tBP\te\tregulation of viral genome replication\t20/40\t20/263\t2.81e-19\t7\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0031347\tBP\te\tregulation of defense response\t20/40\t20/263\t2.81e-19\t5\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0061844\tBP\te\tantimicrobial humoral immune response mediated by antimicrobial peptide\t20/40\t20/263\t2.81e-19\t6\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0050792\tBP\te\tregulation of viral process \t20/40\t20/263\t2.81e-19\t5\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0001906\tBP\te\tcell killing \t20/40\t20/263\t2.81e-19\t1\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0034145\tBP\te\tpositive regulation of toll-like receptor 4 signaling pathway\t20/40\t20/263\t2.81e-19\t9\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0034123\tBP\te\tpositive regulation of toll-like receptor signaling pathway\t20/40\t20/263\t2.81e-19\t8\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051090\tBP\te\tregulation of DNA-binding transcription factor activity\t20/40\t20/263\t2.81e-19\t10\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051817\tBP\te\tmodification of morphology or physiology of other organism involved in symbiotic interaction\t20/40\t20/263\t2.81e-19\t4\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051702\tBP\te\tinteraction with symbiont \t20/40\t20/263\t2.81e-19\t3\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0044793\tBP\te\tnegative regulation by host of viral process\t20/40\t20/263\t2.81e-19\t7\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0032780\tBP\te\tnegative regulation of ATPase activity\t20/40\t20/263\t2.81e-19\t6\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0050776\tBP\te\tregulation of immune response \t20/40\t20/263\t2.81e-19\t4\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051851\tBP\te\tmodification by host of symbiont morphology or physiology\t20/40\t20/263\t2.81e-19\t5\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0044364\tBP\te\tdisruption of cells of other organism\t20/40\t20/263\t2.81e-19\t4\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0044419\tBP\te\tinterspecies interaction between organisms\t20/40\t20/263\t2.81e-19\t2\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0048525\tBP\te\tnegative regulation of viral process\t20/40\t20/263\t2.81e-19\t6\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0002684\tBP\te\tpositive regulation of immune system process\t20/40\t20/263\t2.81e-19\t4\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0045071\tBP\te\tnegative regulation of viral genome replication\t20/40\t20/263\t2.81e-19\t8\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051091\tBP\te\tpositive regulation of DNA-binding transcription factor activity\t20/40\t20/263\t2.81e-19\t11\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0044788\tBP\te\tmodulation by host of viral process\t20/40\t20/263\t2.81e-19\t6\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0045089\tBP\te\tpositive regulation of innate immune response\t20/40\t20/263\t2.81e-19\t7\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0035821\tBP\te\tmodification of morphology or physiology of other organism\t20/40\t20/263\t2.81e-19\t3\t20\t6.39e-19\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051347\tBP\te\tpositive regulation of transferase activity\t20/40\t21/263\t5.43e-18\t5\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0044093\tBP\te\tpositive regulation of molecular function\t20/40\t21/263\t5.43e-18\t3\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0009889\tBP\te\tregulation of biosynthetic process\t20/40\t21/263\t5.43e-18\t4\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0023056\tBP\te\tpositive regulation of signaling\t20/40\t21/263\t5.43e-18\t4\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0042325\tBP\te\tregulation of phosphorylation \t20/40\t21/263\t5.43e-18\t7\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0043549\tBP\te\tregulation of kinase activity \t20/40\t21/263\t5.43e-18\t8\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:1902531\tBP\te\tregulation of intracellular signal transduction\t20/40\t21/263\t5.43e-18\t6\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:2000112\tBP\te\tregulation of cellular macromolecule biosynthetic process\t20/40\t21/263\t5.43e-18\t6\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0048584\tBP\te\tpositive regulation of response to stimulus\t20/40\t21/263\t5.43e-18\t4\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0045859\tBP\te\tregulation of protein kinase activity\t20/40\t21/263\t5.43e-18\t9\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0031326\tBP\te\tregulation of cellular biosynthetic process\t20/40\t21/263\t5.43e-18\t5\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0010556\tBP\te\tregulation of macromolecule biosynthetic process\t20/40\t21/263\t5.43e-18\t5\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0045937\tBP\te\tpositive regulation of phosphate metabolic process\t20/40\t21/263\t5.43e-18\t7\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0019220\tBP\te\tregulation of phosphate metabolic process\t20/40\t21/263\t5.43e-18\t6\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0009967\tBP\te\tpositive regulation of signal transduction\t20/40\t21/263\t5.43e-18\t6\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0071900\tBP\te\tregulation of protein serine/threonine kinase activity\t20/40\t21/263\t5.43e-18\t10\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051174\tBP\te\tregulation of phosphorus metabolic process\t20/40\t21/263\t5.43e-18\t5\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051252\tBP\te\tregulation of RNA metabolic process\t20/40\t21/263\t5.43e-18\t6\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0071902\tBP\te\tpositive regulation of protein serine/threonine kinase activity\t20/40\t21/263\t5.43e-18\t11\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0010562\tBP\te\tpositive regulation of phosphorus metabolic process\t20/40\t21/263\t5.43e-18\t6\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0001932\tBP\te\tregulation of protein phosphorylation\t20/40\t21/263\t5.43e-18\t8\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0033674\tBP\te\tpositive regulation of kinase activity\t20/40\t21/263\t5.43e-18\t9\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:1902533\tBP\te\tpositive regulation of intracellular signal transduction\t20/40\t21/263\t5.43e-18\t7\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0031401\tBP\te\tpositive regulation of protein modification process\t20/40\t21/263\t5.43e-18\t8\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:1903506\tBP\te\tregulation of nucleic acid-templated transcription\t20/40\t21/263\t5.43e-18\t8\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0045860\tBP\te\tpositive regulation of protein kinase activity\t20/40\t21/263\t5.43e-18\t10\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0019219\tBP\te\tregulation of nucleobase-containing compound metabolic process\t20/40\t21/263\t5.43e-18\t5\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0080134\tBP\te\tregulation of response to stress\t20/40\t21/263\t5.43e-18\t4\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0043085\tBP\te\tpositive regulation of catalytic activity\t20/40\t21/263\t5.43e-18\t4\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051338\tBP\te\tregulation of transferase activity\t20/40\t21/263\t5.43e-18\t4\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0042327\tBP\te\tpositive regulation of phosphorylation\t20/40\t21/263\t5.43e-18\t8\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0031399\tBP\te\tregulation of protein modification process\t20/40\t21/263\t5.43e-18\t7\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0006355\tBP\te\tregulation of transcription, DNA-templated\t20/40\t21/263\t5.43e-18\t9\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:2001141\tBP\te\tregulation of RNA biosynthetic process\t20/40\t21/263\t5.43e-18\t7\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0010647\tBP\te\tpositive regulation of cell communication\t20/40\t21/263\t5.43e-18\t5\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0001934\tBP\te\tpositive regulation of protein phosphorylation\t20/40\t21/263\t5.43e-18\t9\t20\t1.03e-17\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0010604\tBP\te\tpositive regulation of macromolecule metabolic process\t20/40\t48/263\t4.21e-07\t5\t20\t7.63e-07\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0031325\tBP\te\tpositive regulation of cellular metabolic process\t20/40\t48/263\t4.21e-07\t5\t20\t7.63e-07\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051173\tBP\te\tpositive regulation of nitrogen compound metabolic process\t20/40\t48/263\t4.21e-07\t5\t20\t7.63e-07\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0010468\tBP\te\tregulation of gene expression \t20/40\t48/263\t4.21e-07\t5\t20\t7.63e-07\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051247\tBP\te\tpositive regulation of protein metabolic process\t20/40\t48/263\t4.21e-07\t6\t20\t7.63e-07\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0009893\tBP\te\tpositive regulation of metabolic process\t20/40\t48/263\t4.21e-07\t4\t20\t7.63e-07\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0032270\tBP\te\tpositive regulation of cellular protein metabolic process\t20/40\t48/263\t4.21e-07\t7\t20\t7.63e-07\tAILME19349, BOVIN10421, CHLSB10290, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MOUSE53077, MUSPF09885, MYOLU10560, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, RABIT12763, RATNO20342, SHEEP08528\n", "GO:0051234\tBP\te\testablishment of localization \t39/40\t207/263\t0.000605\t2\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0050801\tBP\te\tion homeostasis \t39/40\t207/263\t0.000605\t5\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0055072\tBP\te\tiron ion homeostasis \t39/40\t207/263\t0.000605\t9\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0055080\tBP\te\tcation homeostasis \t39/40\t207/263\t0.000605\t6\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0051179\tBP\te\tlocalization \t39/40\t207/263\t0.000605\t1\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0098771\tBP\te\tinorganic ion homeostasis \t39/40\t207/263\t0.000605\t6\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0055076\tBP\te\ttransition metal ion homeostasis\t39/40\t207/263\t0.000605\t8\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0065008\tBP\te\tregulation of biological quality\t39/40\t207/263\t0.000605\t2\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006811\tBP\te\tion transport \t39/40\t207/263\t0.000605\t4\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0048878\tBP\te\tchemical homeostasis \t39/40\t207/263\t0.000605\t4\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0055065\tBP\te\tmetal ion homeostasis \t39/40\t207/263\t0.000605\t7\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0042592\tBP\te\thomeostatic process \t39/40\t207/263\t0.000605\t3\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006810\tBP\te\ttransport \t39/40\t207/263\t0.000605\t3\t39\t0.00101\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0065007\tBP\te\tbiological regulation \t39/40\t227/263\t0.0234\t1\t39\t0.0351\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0008150\tBP\te\tbiological_process \t39/40\t227/263\t0.0234\t0\t39\t0.0351\tAILME19349, BOVIN10421, CALJA07214, CANLF07574, CAVPO15803, CHILA06139, CHLSB10290, DASNO15901, FELCA01815, FUKDA00881, GORGO13640, HORSE06788, HUMAN20795, ICTTR00008, LOXAF14821, MACMU13343, MICMU05125, MOUSE53077, MUSPF09885, MYOLU10560, NANGA19399, NOMLE02731, OCHPR01366, OCTDE19528, OTOGA08096, PANPA27700, PANTR30966, PAPAN10531, PIGXX03930, PONAB10845, PROCA07246, PTEVA02104, RABIT12763, RATNO20342, SHEEP08528, SORAR11450, TARSY07060, TURTR11384, VICPA07246\n", "GO:0006826\tBP\tp\tiron ion transport \t0/40\t86/263\t4.76e-08\t8\t0\t8.9e-08\t \n", "GO:0006812\tBP\tp\tcation transport \t0/40\t86/263\t4.76e-08\t5\t0\t8.9e-08\t \n", "GO:0030001\tBP\tp\tmetal ion transport \t0/40\t86/263\t4.76e-08\t6\t0\t8.9e-08\t \n", "GO:0000041\tBP\tp\ttransition metal ion transport\t0/40\t86/263\t4.76e-08\t7\t0\t8.9e-08\t \n", "GO:0009987\tBP\tp\tcellular process \t1/40\t70/263\t3.01e-05\t1\t1\t5.44e-05\t HUMAN20795\n", "GO:0055082\tBP\tp\tcellular chemical homeostasis \t0/40\t58/263\t3.65e-05\t5\t0\t6.4e-05\t \n", "GO:0006879\tBP\tp\tcellular iron ion homeostasis \t0/40\t58/263\t3.65e-05\t10\t0\t6.4e-05\t \n", "GO:0030003\tBP\tp\tcellular cation homeostasis \t0/40\t58/263\t3.65e-05\t7\t0\t6.4e-05\t \n", "GO:0006875\tBP\tp\tcellular metal ion homeostasis\t0/40\t58/263\t3.65e-05\t8\t0\t6.4e-05\t \n", "GO:0019725\tBP\tp\tcellular homeostasis \t0/40\t58/263\t3.65e-05\t4\t0\t6.4e-05\t \n", "GO:0046916\tBP\tp\tcellular transition metal ion homeostasis\t0/40\t58/263\t3.65e-05\t9\t0\t6.4e-05\t \n", "GO:0006873\tBP\tp\tcellular ion homeostasis \t0/40\t58/263\t3.65e-05\t6\t0\t6.4e-05\t \n", "GO:0051128\tBP\tp\tregulation of cellular component organization\t0/40\t42/263\t0.000739\t4\t0\t0.00122\t \n", "GO:0051130\tBP\tp\tpositive regulation of cellular component organization\t0/40\t42/263\t0.000739\t5\t0\t0.00122\t \n", "GO:0010628\tBP\tp\tpositive regulation of gene expression\t0/40\t28/263\t0.0112\t6\t0\t0.0184\t \n", "GO:1903053\tBP\tp\tregulation of extracellular matrix organization\t0/40\t27/263\t0.0195\t5\t0\t0.0295\t \n", "GO:0022603\tBP\tp\tregulation of anatomical structure morphogenesis\t0/40\t27/263\t0.0195\t4\t0\t0.0295\t \n", "GO:1900025\tBP\tp\tnegative regulation of substrate adhesion-dependent cell spreading\t0/40\t27/263\t0.0195\t8\t0\t0.0295\t \n", "GO:0010810\tBP\tp\tregulation of cell-substrate adhesion\t0/40\t27/263\t0.0195\t4\t0\t0.0295\t \n", "GO:0010954\tBP\tp\tpositive regulation of protein processing\t0/40\t27/263\t0.0195\t9\t0\t0.0295\t \n", "GO:0090091\tBP\tp\tpositive regulation of extracellular matrix disassembly\t0/40\t27/263\t0.0195\t7\t0\t0.0295\t \n", "GO:0010812\tBP\tp\tnegative regulation of cell-substrate adhesion\t0/40\t27/263\t0.0195\t6\t0\t0.0295\t \n", "GO:0010715\tBP\tp\tregulation of extracellular matrix disassembly\t0/40\t27/263\t0.0195\t6\t0\t0.0295\t \n", "GO:0070613\tBP\tp\tregulation of protein processing\t0/40\t27/263\t0.0195\t7\t0\t0.0295\t \n", "GO:1903317\tBP\tp\tregulation of protein maturation\t0/40\t27/263\t0.0195\t6\t0\t0.0295\t \n", "GO:0022604\tBP\tp\tregulation of cell morphogenesis\t0/40\t27/263\t0.0195\t5\t0\t0.0295\t \n", "GO:0045862\tBP\tp\tpositive regulation of proteolysis\t0/40\t27/263\t0.0195\t8\t0\t0.0295\t \n", "GO:0010756\tBP\tp\tpositive regulation of plasminogen activation\t0/40\t27/263\t0.0195\t10\t0\t0.0295\t \n", "GO:0030155\tBP\tp\tregulation of cell adhesion \t0/40\t27/263\t0.0195\t3\t0\t0.0295\t \n", "GO:0010771\tBP\tp\tnegative regulation of cell morphogenesis involved in differentiation\t0/40\t27/263\t0.0195\t7\t0\t0.0295\t \n", "GO:0051129\tBP\tp\tnegative regulation of cellular component organization\t0/40\t27/263\t0.0195\t5\t0\t0.0295\t \n", "GO:1903055\tBP\tp\tpositive regulation of extracellular matrix organization\t0/40\t27/263\t0.0195\t6\t0\t0.0295\t \n", "GO:1903319\tBP\tp\tpositive regulation of protein maturation\t0/40\t27/263\t0.0195\t7\t0\t0.0295\t \n", "GO:0010769\tBP\tp\tregulation of cell morphogenesis involved in differentiation\t0/40\t27/263\t0.0195\t6\t0\t0.0295\t \n", "GO:0010755\tBP\tp\tregulation of plasminogen activation\t0/40\t27/263\t0.0195\t8\t0\t0.0295\t \n", "GO:1900024\tBP\tp\tregulation of substrate adhesion-dependent cell spreading\t0/40\t27/263\t0.0195\t7\t0\t0.0295\t \n", "GO:0007162\tBP\tp\tnegative regulation of cell adhesion\t0/40\t27/263\t0.0195\t5\t0\t0.0295\t \n" ] } ], "source": [ "goea.print_results(results)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "It's also possible to convert this into a data frame, for further analysis. However, there's currently no built-in support for this in GOATOOLS." ] }, { "cell_type": "code", "execution_count": 26, "metadata": {}, "outputs": [], "source": [ "import pandas as pd\n", "res = pd.DataFrame.from_records((dict(zip(z.get_prtflds_default(), \n", " z.get_field_values(z.get_prtflds_default()))) \n", " for z in goea.get_adj_records(results)))" ] }, { "cell_type": "code", "execution_count": 27, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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GONSdepthenrichmentnamep_fdr_bhp_uncorrectedratio_in_popratio_in_studystudy_countstudy_items
0GO:1900228BP5eregulation of single-species biofilm formation...5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
1GO:0043900BP3eregulation of multi-organism process5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
2GO:0032101BP4eregulation of response to external stimulus5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
3GO:1903011BP6enegative regulation of bone development5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
4GO:0002682BP3eregulation of immune system process5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
5GO:0030501BP7epositive regulation of bone mineralization5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
6GO:1902105BP6eregulation of leukocyte differentiation5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
7GO:0002831BP4eregulation of response to biotic stimulus5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
8GO:1900157BP7eregulation of bone mineralization involved in ...5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
9GO:0043903BP4eregulation of symbiosis, encompassing mutualis...5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
10GO:0002832BP5enegative regulation of response to biotic stim...5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
11GO:1903012BP6epositive regulation of bone development5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
12GO:0045667BP5eregulation of osteoblast differentiation5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
13GO:0045670BP8eregulation of osteoclast differentiation5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
14GO:0031665BP7enegative regulation of lipopolysaccharide-medi...5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
15GO:1903010BP5eregulation of bone development5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
16GO:2001204BP9eregulation of osteoclast development5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
17GO:0032102BP5enegative regulation of response to external st...5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
18GO:0032501BP1emulticellular organismal process5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
19GO:0030278BP4eregulation of ossification5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
20GO:0060349BP4ebone morphogenesis5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
21GO:0070167BP5eregulation of biomineral tissue development5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
22GO:0001818BP5enegative regulation of cytokine production5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
23GO:0032680BP6eregulation of tumor necrosis factor production5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
24GO:0001817BP4eregulation of cytokine production5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
25GO:0002683BP4enegative regulation of immune system process5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
26GO:0045669BP6epositive regulation of osteoblast differentiation5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
27GO:0001503BP2eossification5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
28GO:0045778BP5epositive regulation of ossification5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
29GO:0031664BP6eregulation of lipopolysaccharide-mediated sign...5.168715e-456.629705e-4639/26339/4039AILME19349, BOVIN10421, CALJA07214, CANLF07574...
....................................
250GO:0030003BP7pcellular cation homeostasis6.395619e-053.645958e-0558/2630/400
251GO:0006875BP8pcellular metal ion homeostasis6.395619e-053.645958e-0558/2630/400
252GO:0019725BP4pcellular homeostasis6.395619e-053.645958e-0558/2630/400
253GO:0046916BP9pcellular transition metal ion homeostasis6.395619e-053.645958e-0558/2630/400
254GO:0006873BP6pcellular ion homeostasis6.395619e-053.645958e-0558/2630/400
255GO:0051128BP4pregulation of cellular component organization1.220805e-037.394423e-0442/2630/400
256GO:0051130BP5ppositive regulation of cellular component orga...1.220805e-037.394423e-0442/2630/400
257GO:0010628BP6ppositive regulation of gene expression1.837141e-021.117121e-0228/2630/400
258GO:1903053BP5pregulation of extracellular matrix organization2.948552e-021.947025e-0227/2630/400
259GO:0022603BP4pregulation of anatomical structure morphogenesis2.948552e-021.947025e-0227/2630/400
260GO:1900025BP8pnegative regulation of substrate adhesion-depe...2.948552e-021.947025e-0227/2630/400
261GO:0010810BP4pregulation of cell-substrate adhesion2.948552e-021.947025e-0227/2630/400
262GO:0010954BP9ppositive regulation of protein processing2.948552e-021.947025e-0227/2630/400
263GO:0090091BP7ppositive regulation of extracellular matrix di...2.948552e-021.947025e-0227/2630/400
264GO:0010812BP6pnegative regulation of cell-substrate adhesion2.948552e-021.947025e-0227/2630/400
265GO:0010715BP6pregulation of extracellular matrix disassembly2.948552e-021.947025e-0227/2630/400
266GO:0070613BP7pregulation of protein processing2.948552e-021.947025e-0227/2630/400
267GO:1903317BP6pregulation of protein maturation2.948552e-021.947025e-0227/2630/400
268GO:0022604BP5pregulation of cell morphogenesis2.948552e-021.947025e-0227/2630/400
269GO:0045862BP8ppositive regulation of proteolysis2.948552e-021.947025e-0227/2630/400
270GO:0010756BP10ppositive regulation of plasminogen activation2.948552e-021.947025e-0227/2630/400
271GO:0030155BP3pregulation of cell adhesion2.948552e-021.947025e-0227/2630/400
272GO:0010771BP7pnegative regulation of cell morphogenesis invo...2.948552e-021.947025e-0227/2630/400
273GO:0051129BP5pnegative regulation of cellular component orga...2.948552e-021.947025e-0227/2630/400
274GO:1903055BP6ppositive regulation of extracellular matrix or...2.948552e-021.947025e-0227/2630/400
275GO:1903319BP7ppositive regulation of protein maturation2.948552e-021.947025e-0227/2630/400
276GO:0010769BP6pregulation of cell morphogenesis involved in d...2.948552e-021.947025e-0227/2630/400
277GO:0010755BP8pregulation of plasminogen activation2.948552e-021.947025e-0227/2630/400
278GO:1900024BP7pregulation of substrate adhesion-dependent cel...2.948552e-021.947025e-0227/2630/400
279GO:0007162BP5pnegative regulation of cell adhesion2.948552e-021.947025e-0227/2630/400
\n", "

280 rows × 11 columns

\n", "
" ], "text/plain": [ " GO NS depth enrichment \\\n", "0 GO:1900228 BP 5 e \n", "1 GO:0043900 BP 3 e \n", "2 GO:0032101 BP 4 e \n", "3 GO:1903011 BP 6 e \n", "4 GO:0002682 BP 3 e \n", "5 GO:0030501 BP 7 e \n", "6 GO:1902105 BP 6 e \n", "7 GO:0002831 BP 4 e \n", "8 GO:1900157 BP 7 e \n", "9 GO:0043903 BP 4 e \n", "10 GO:0002832 BP 5 e \n", "11 GO:1903012 BP 6 e \n", "12 GO:0045667 BP 5 e \n", "13 GO:0045670 BP 8 e \n", "14 GO:0031665 BP 7 e \n", "15 GO:1903010 BP 5 e \n", "16 GO:2001204 BP 9 e \n", "17 GO:0032102 BP 5 e \n", "18 GO:0032501 BP 1 e \n", "19 GO:0030278 BP 4 e \n", "20 GO:0060349 BP 4 e \n", "21 GO:0070167 BP 5 e \n", "22 GO:0001818 BP 5 e \n", "23 GO:0032680 BP 6 e \n", "24 GO:0001817 BP 4 e \n", "25 GO:0002683 BP 4 e \n", "26 GO:0045669 BP 6 e \n", "27 GO:0001503 BP 2 e \n", "28 GO:0045778 BP 5 e \n", "29 GO:0031664 BP 6 e \n", ".. ... .. ... ... \n", "250 GO:0030003 BP 7 p \n", "251 GO:0006875 BP 8 p \n", "252 GO:0019725 BP 4 p \n", "253 GO:0046916 BP 9 p \n", "254 GO:0006873 BP 6 p \n", "255 GO:0051128 BP 4 p \n", "256 GO:0051130 BP 5 p \n", "257 GO:0010628 BP 6 p \n", "258 GO:1903053 BP 5 p \n", "259 GO:0022603 BP 4 p \n", "260 GO:1900025 BP 8 p \n", "261 GO:0010810 BP 4 p \n", "262 GO:0010954 BP 9 p \n", "263 GO:0090091 BP 7 p \n", "264 GO:0010812 BP 6 p \n", "265 GO:0010715 BP 6 p \n", "266 GO:0070613 BP 7 p \n", "267 GO:1903317 BP 6 p \n", "268 GO:0022604 BP 5 p \n", "269 GO:0045862 BP 8 p \n", "270 GO:0010756 BP 10 p \n", "271 GO:0030155 BP 3 p \n", "272 GO:0010771 BP 7 p \n", "273 GO:0051129 BP 5 p \n", "274 GO:1903055 BP 6 p \n", "275 GO:1903319 BP 7 p \n", "276 GO:0010769 BP 6 p \n", "277 GO:0010755 BP 8 p \n", "278 GO:1900024 BP 7 p \n", "279 GO:0007162 BP 5 p \n", "\n", " name p_fdr_bh \\\n", "0 regulation of single-species biofilm formation... 5.168715e-45 \n", "1 regulation of multi-organism process 5.168715e-45 \n", "2 regulation of response to external stimulus 5.168715e-45 \n", "3 negative regulation of bone development 5.168715e-45 \n", "4 regulation of immune system process 5.168715e-45 \n", "5 positive regulation of bone mineralization 5.168715e-45 \n", "6 regulation of leukocyte differentiation 5.168715e-45 \n", "7 regulation of response to biotic stimulus 5.168715e-45 \n", "8 regulation of bone mineralization involved in ... 5.168715e-45 \n", "9 regulation of symbiosis, encompassing mutualis... 5.168715e-45 \n", "10 negative regulation of response to biotic stim... 5.168715e-45 \n", "11 positive regulation of bone development 5.168715e-45 \n", "12 regulation of osteoblast differentiation 5.168715e-45 \n", "13 regulation of osteoclast differentiation 5.168715e-45 \n", "14 negative regulation of lipopolysaccharide-medi... 5.168715e-45 \n", "15 regulation of bone development 5.168715e-45 \n", "16 regulation of osteoclast development 5.168715e-45 \n", "17 negative regulation of response to external st... 5.168715e-45 \n", "18 multicellular organismal process 5.168715e-45 \n", "19 regulation of ossification 5.168715e-45 \n", "20 bone morphogenesis 5.168715e-45 \n", "21 regulation of biomineral tissue development 5.168715e-45 \n", "22 negative regulation of cytokine production 5.168715e-45 \n", "23 regulation of tumor necrosis factor production 5.168715e-45 \n", "24 regulation of cytokine production 5.168715e-45 \n", "25 negative regulation of immune system process 5.168715e-45 \n", "26 positive regulation of osteoblast differentiation 5.168715e-45 \n", "27 ossification 5.168715e-45 \n", "28 positive regulation of ossification 5.168715e-45 \n", "29 regulation of lipopolysaccharide-mediated sign... 5.168715e-45 \n", ".. ... ... \n", "250 cellular cation homeostasis 6.395619e-05 \n", "251 cellular metal ion homeostasis 6.395619e-05 \n", "252 cellular homeostasis 6.395619e-05 \n", "253 cellular transition metal ion homeostasis 6.395619e-05 \n", "254 cellular ion homeostasis 6.395619e-05 \n", "255 regulation of cellular component organization 1.220805e-03 \n", "256 positive regulation of cellular component orga... 1.220805e-03 \n", "257 positive regulation of gene expression 1.837141e-02 \n", "258 regulation of extracellular matrix organization 2.948552e-02 \n", "259 regulation of anatomical structure morphogenesis 2.948552e-02 \n", "260 negative regulation of substrate adhesion-depe... 2.948552e-02 \n", "261 regulation of cell-substrate adhesion 2.948552e-02 \n", "262 positive regulation of protein processing 2.948552e-02 \n", "263 positive regulation of extracellular matrix di... 2.948552e-02 \n", "264 negative regulation of cell-substrate adhesion 2.948552e-02 \n", "265 regulation of extracellular matrix disassembly 2.948552e-02 \n", "266 regulation of protein processing 2.948552e-02 \n", "267 regulation of protein maturation 2.948552e-02 \n", "268 regulation of cell morphogenesis 2.948552e-02 \n", "269 positive regulation of proteolysis 2.948552e-02 \n", "270 positive regulation of plasminogen activation 2.948552e-02 \n", "271 regulation of cell adhesion 2.948552e-02 \n", "272 negative regulation of cell morphogenesis invo... 2.948552e-02 \n", "273 negative regulation of cellular component orga... 2.948552e-02 \n", "274 positive regulation of extracellular matrix or... 2.948552e-02 \n", "275 positive regulation of protein maturation 2.948552e-02 \n", "276 regulation of cell morphogenesis involved in d... 2.948552e-02 \n", "277 regulation of plasminogen activation 2.948552e-02 \n", "278 regulation of substrate adhesion-dependent cel... 2.948552e-02 \n", "279 negative regulation of cell adhesion 2.948552e-02 \n", "\n", " p_uncorrected ratio_in_pop ratio_in_study study_count \\\n", "0 6.629705e-46 39/263 39/40 39 \n", "1 6.629705e-46 39/263 39/40 39 \n", "2 6.629705e-46 39/263 39/40 39 \n", "3 6.629705e-46 39/263 39/40 39 \n", "4 6.629705e-46 39/263 39/40 39 \n", "5 6.629705e-46 39/263 39/40 39 \n", "6 6.629705e-46 39/263 39/40 39 \n", "7 6.629705e-46 39/263 39/40 39 \n", "8 6.629705e-46 39/263 39/40 39 \n", "9 6.629705e-46 39/263 39/40 39 \n", "10 6.629705e-46 39/263 39/40 39 \n", "11 6.629705e-46 39/263 39/40 39 \n", "12 6.629705e-46 39/263 39/40 39 \n", "13 6.629705e-46 39/263 39/40 39 \n", "14 6.629705e-46 39/263 39/40 39 \n", "15 6.629705e-46 39/263 39/40 39 \n", "16 6.629705e-46 39/263 39/40 39 \n", "17 6.629705e-46 39/263 39/40 39 \n", "18 6.629705e-46 39/263 39/40 39 \n", "19 6.629705e-46 39/263 39/40 39 \n", "20 6.629705e-46 39/263 39/40 39 \n", "21 6.629705e-46 39/263 39/40 39 \n", "22 6.629705e-46 39/263 39/40 39 \n", "23 6.629705e-46 39/263 39/40 39 \n", "24 6.629705e-46 39/263 39/40 39 \n", "25 6.629705e-46 39/263 39/40 39 \n", "26 6.629705e-46 39/263 39/40 39 \n", "27 6.629705e-46 39/263 39/40 39 \n", "28 6.629705e-46 39/263 39/40 39 \n", "29 6.629705e-46 39/263 39/40 39 \n", ".. ... ... ... ... \n", "250 3.645958e-05 58/263 0/40 0 \n", "251 3.645958e-05 58/263 0/40 0 \n", "252 3.645958e-05 58/263 0/40 0 \n", "253 3.645958e-05 58/263 0/40 0 \n", "254 3.645958e-05 58/263 0/40 0 \n", "255 7.394423e-04 42/263 0/40 0 \n", "256 7.394423e-04 42/263 0/40 0 \n", "257 1.117121e-02 28/263 0/40 0 \n", "258 1.947025e-02 27/263 0/40 0 \n", "259 1.947025e-02 27/263 0/40 0 \n", "260 1.947025e-02 27/263 0/40 0 \n", "261 1.947025e-02 27/263 0/40 0 \n", "262 1.947025e-02 27/263 0/40 0 \n", "263 1.947025e-02 27/263 0/40 0 \n", "264 1.947025e-02 27/263 0/40 0 \n", "265 1.947025e-02 27/263 0/40 0 \n", "266 1.947025e-02 27/263 0/40 0 \n", "267 1.947025e-02 27/263 0/40 0 \n", "268 1.947025e-02 27/263 0/40 0 \n", "269 1.947025e-02 27/263 0/40 0 \n", "270 1.947025e-02 27/263 0/40 0 \n", "271 1.947025e-02 27/263 0/40 0 \n", "272 1.947025e-02 27/263 0/40 0 \n", "273 1.947025e-02 27/263 0/40 0 \n", "274 1.947025e-02 27/263 0/40 0 \n", "275 1.947025e-02 27/263 0/40 0 \n", "276 1.947025e-02 27/263 0/40 0 \n", "277 1.947025e-02 27/263 0/40 0 \n", "278 1.947025e-02 27/263 0/40 0 \n", "279 1.947025e-02 27/263 0/40 0 \n", "\n", " study_items \n", "0 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "1 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "2 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "3 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "4 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "5 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "6 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "7 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "8 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "9 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "10 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "11 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "12 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "13 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "14 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "15 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "16 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "17 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "18 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "19 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "20 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "21 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "22 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "23 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "24 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "25 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "26 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "27 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "28 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", "29 AILME19349, BOVIN10421, CALJA07214, CANLF07574... \n", ".. ... \n", "250 \n", "251 \n", "252 \n", "253 \n", "254 \n", "255 \n", "256 \n", "257 \n", "258 \n", "259 \n", "260 \n", "261 \n", "262 \n", "263 \n", "264 \n", "265 \n", "266 \n", "267 \n", "268 \n", "269 \n", "270 \n", "271 \n", "272 \n", "273 \n", "274 \n", "275 \n", "276 \n", "277 \n", "278 \n", "279 \n", "\n", "[280 rows x 11 columns]" ] }, "execution_count": 27, "metadata": {}, "output_type": "execute_result" } ], "source": [ "res" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "---" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "## Example 3 - Taxonomic Tree Visualisation\n", "Here, we look at how to load the current taxonomy in the OMA browser. Options are available to retrieve the Newick string or PhyloXML are available.\n", "\n", "Further, methods to preload into a dendropy or ete3 tree object are available, in order to fit into many current workflows." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "We can grab the PhyloXML for the entire taxonomy." ] }, { "cell_type": "code", "execution_count": 28, "metadata": {}, "outputs": [], "source": [ "xml = c.taxonomy.get(format='phyloxml')" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "We can retrieve a Newick string for the taxonomy. This can then be used in, for instance, Phylo.io." ] }, { "cell_type": "code", "execution_count": 29, "metadata": {}, "outputs": [], "source": [ "nwk = c.taxonomy.get(members=['PONAB', 'GORGO', 'PANPA', 'PANTR', 'HUMAN', 'NOMLE'], format='newick')" ] }, { "cell_type": "code", "execution_count": 30, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "((Pongo_abelii,(Gorilla_gorilla_gorilla,(Pan_paniscus,Pan_troglodytes)Pan,Homo_sapiens)Homininae)Hominidae,Nomascus_leucogenys)Hominoidea;\n" ] } ], "source": [ "print(nwk)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "We can also use the methods to load dendropy / ete3 trees. Note, dendropy and ete3 are optional dependencies to the `omadb` package, so will not have been installed automatically." ] }, { "cell_type": "code", "execution_count": 31, "metadata": {}, "outputs": [], "source": [ "dendropy_tree = c.taxonomy.dendropy_tree(root='Hominoidea')" ] }, { "cell_type": "code", "execution_count": 32, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ " /------------------------------------------------------ PONAB\n", " | \n", "/-----------------+ /------------------------------------ GORGO\n", "| | | \n", "| | | /------------------ PANPA\n", "| \\-----------------+-----------------+ \n", "+ | \\------------------ PANTR\n", "| | \n", "| \\------------------------------------ HUMAN\n", "| \n", "\\------------------------------------------------------------------------ NOMLE\n", " \n", " \n" ] } ], "source": [ "print(dendropy_tree.as_ascii_plot())" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Alternatively, we can load with the species names instead of the UniProt species codes." ] }, { "cell_type": "code", "execution_count": 33, "metadata": {}, "outputs": [], "source": [ "dendropy_tree = c.taxonomy.dendropy_tree(root='Hominoidea', with_names=True)" ] }, { "cell_type": "code", "execution_count": 34, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ " /----------------------------------------- Pongo abelii \n", " | \n", "/------------+ /--------------------------- Gorilla gorilla gorilla\n", "| | | \n", "| | | /------------- Pan paniscus \n", "| \\-------------+-------------+ \n", "+ | \\------------- Pan troglodytes \n", "| | \n", "| \\--------------------------- Homo sapiens \n", "| \n", "\\------------------------------------------------------ Nomascus leucogenys \n", " \n", " \n" ] } ], "source": [ "print(dendropy_tree.as_ascii_plot())" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "We can also load into the ete3 tree, as so" ] }, { "cell_type": "code", "execution_count": 35, "metadata": {}, "outputs": [], "source": [ "ete_tree = c.taxonomy.ete_tree(root='Hominoidea', with_names=True)" ] }, { "cell_type": "code", "execution_count": 36, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "\n", " /-Pongo abelii\n", " |\n", " /-| /-Gorilla gorilla gorilla\n", " | | |\n", " | | | /-Pan paniscus\n", " | \\-|--|\n", "--| | \\-Pan troglodytes\n", " | |\n", " | \\-Homo sapiens\n", " |\n", " \\-Nomascus leucogenys\n" ] } ], "source": [ "print(ete_tree)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "ETE also supports \"pretty\" plotting. For this, you will require PyQt4 (installable using: `conda install \"pyqt<5\"`)." ] }, { "cell_type": "code", "execution_count": 37, "metadata": {}, "outputs": [ { "data": { "image/png": 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\n", "text/plain": [ "" ] }, "execution_count": 37, "metadata": {}, "output_type": "execute_result" } ], "source": [ "#ete_tree.render('%%inline')" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "---" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "## Example 4 - Visualising the Distribution of PAM Distances in the Taxonomic Space\n", "\n", "In this example, we compare the distribution of the evolutionary distance (in PAM units) between the 1:1 pairwise orthologues between Human and _Mus musculus_ (Mouse) as well as Human and _Canis lupus familiaris_ (Dog).\n", "\n", "We start by loading the pairwise data for 1:1 orthologues." ] }, { "cell_type": "code", "execution_count": 38, "metadata": {}, "outputs": [], "source": [ "human_mouse_iter = c.pairwise(genome_id1='HUMAN',\n", " genome_id2='MOUSE',\n", " rel_type='1:1',\n", " progress=True)" ] }, { "cell_type": "code", "execution_count": 39, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "" ] }, "execution_count": 39, "metadata": {}, "output_type": "execute_result" } ], "source": [ "human_mouse_iter" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "We have recieved a \"PagedResponse\". As there are a lot of pairwise entries between then two genomes, the response size is limited. The object returned here is a generator which will lazily load the following page of results each time we get to the end.\n", "\n", "We can either use a for loop over this, or capture the entire response in one go. Here, we only want to extract the distance and don't care about any entry information." ] }, { "cell_type": "code", "execution_count": 40, "metadata": {}, "outputs": [ { "name": "stderr", "output_type": "stream", "text": [ "Loading pairs: 66%|██████▋ | 15860/23917 [00:12<00:06, 1281.17 entries/s]\n", "Loading pairs: 84%|████████▍ | 15349/18254 [00:08<00:01, 1762.42 entries/s]\n" ] } ], "source": [ "import numpy as np\n", "\n", "human_mouse = np.array([x.distance for x in human_mouse_iter])\n", "\n", "human_dog = np.array([x.distance for x in c.pairwise(genome_id1='HUMAN',\n", " genome_id2='CANLF',\n", " rel_type='1:1',\n", " progress=True)])" ] }, { "cell_type": "code", "execution_count": 41, "metadata": {}, "outputs": [], "source": [ "%matplotlib inline\n", "import seaborn as sns\n", "sns.set()" ] }, { "cell_type": "code", "execution_count": 42, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "" ] }, "execution_count": 42, "metadata": {}, "output_type": "execute_result" }, { 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\n", "text/plain": [ "" ] }, "metadata": {}, "output_type": "display_data" } ], "source": [ "ax = sns.distplot(human_dog, label='Canis lupus familiaris')\n", "ax = sns.distplot(human_mouse, label='Mus musculus', ax=ax)\n", "\n", "ax.set_title('Distribution of Evolutionary Distance between\\n1:1 Orthologous Pairs HUMAN-{CANLF, MOUSE}')\n", "ax.set_xlabel('Evolutionary Distance (PAM)')\n", "ax.set_ylabel('Density')\n", "ax.legend()" ] }, { "cell_type": "code", "execution_count": 43, "metadata": {}, "outputs": [], "source": [ "from scipy import stats" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "We can use the two sample Kolmogorov-Smirnov test, available in scipy, in order to test whether the two samples are drawn from the same distribution." ] }, { "cell_type": "code", "execution_count": 44, "metadata": {}, "outputs": [], "source": [ "z = stats.ks_2samp(human_mouse, human_dog)" ] }, { "cell_type": "code", "execution_count": 45, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "5.16481402754209e-90" ] }, "execution_count": 45, "metadata": {}, "output_type": "execute_result" } ], "source": [ "z.pvalue" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "This indicates that they are not drawn from the same distribution.\n", "\n", "We can also look at the median / mean distance." ] }, { "cell_type": "code", "execution_count": 46, "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "Median: \n", "HUMAN-MOUSE 11.774700164794922 \n", "HUMAN-CANLF 8.655900001525879\n", "Mean:\n", "HUMAN-MOUSE 16.42020220052249 \n", "HUMAN-CANLF 12.539905405603653\n" ] } ], "source": [ "print('Median:',\n", " '\\nHUMAN-MOUSE', np.median(human_mouse),\n", " '\\nHUMAN-CANLF', np.median(human_dog))\n", "\n", "print('Mean:'\n", " '\\nHUMAN-MOUSE', np.mean(human_mouse),\n", " '\\nHUMAN-CANLF', np.mean(human_dog))" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "The mean distance between HUMAN and CANLF is less than that of HUMAN and MOUSE. This is consistent with previous observations that the rodent has a longer branch than humans and carnivores." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "---" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "## Example 5 - annotating protein sequences not present in OMA\n", "\n", "Although the OMA database currently analyses over 2,100 genomes, many more have been sequenced, and the gap keeps on widening. It is nevertheless possible to use OMA to infer the function of custom protein sequences through a fast approximate search against all sequences in OMA." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Here, we show this fast mapping, with a mystery gene (the cystic fibrosis transmembrane conductance regulator in the Emperor penguin -- `A0A087RGQ1_APTFO`)." ] }, { "cell_type": "code", "execution_count": 47, "metadata": {}, "outputs": [], "source": [ "mystery_seq = 'FFFLLRWTKPILRKGYRRRLELSDIYQIPSADSADNLSEKLEREWDRELATSKKKPKLINALRRCFFWKFMFYGIILYLGEVTKSVQPLLLGRIIASYDPDNSDERSIAYYLAIGLCLLFLVRTLLIHPAIFGLHHIGMQMRIAMFSLIYKKILKLSSRVLDKISTGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLLWDMLEASAFSGLAFLIVLAFFQAWLGQRMMKYRNKRAGKINERLVITSEIIENIQSVKAYCWEDAMEKMIESIRETELKLTRKAAYVRYFNSSAFFFSGFFVVFLAVLPYAVIKGIILRKIFTTISFCIVLRMTVTRQFPGSVQTWYDSIGAINKIQDFLLKKEYKSLEYNLTTTGVELDKVTAFWDEGIGELFVKANQENNNSKAPSTDNNLFFSNFPLHASPVLQDINFKIEKGQLLAVSGSTGAGKTSLLMLIMGELEPSQGRLKHSGRISFSPQVSWIMPGTIKENIIFGVSYDEYRYKSVIKACQLEEDISKFPDKDYTVLGDGGIILSGGQRARISLARAVYKDADLYLLDSPFGHLDIFTEKEIFESCVCKLMANKTRILVTSKLEHLKIADKILILHEGSCYFYGTFSELQGQRPDFSSELMGFDSFDQFSAERRNSILTETLRRFSIEGEGTGSRNEIKKQSFKQTSDFNDKRKNSIIINPLNASRKFSVVQRNGMQVNGIEDGHNDPPERRFSLVPDLEQGDVGLLRSSMLNTDHILQGRRRQSVLNLMTGTSVNYGPNFSKKGSTTFRKMSMVPQTNLSSEIDIYTRRLSRDSVLDITDEINEEDLKECFTDDAESMGTVTTWNTYFRYVTIHKNLIFVLILCVTVFLVEVAASLAGLWFLKQTALKANTTQSENSTSDKPPVIVTVTSSYYIIYIYVGVADTLLAMGIFRGLPLVHTLITVSKTLHQKMVHAVLHAPMSTFNSWKAGGMLNRFSKDTAVLDDLLPLTVFDFIQLILIVIGAITVVSILQPYIFLASVPVIAAFILLRAYFLHTSQQLKQLESEARSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVVFFVAVAFISIVTTGDGSGKVGIILTLAMNIMGTLQWAVNSSIDVDSLMRSVGRIFKFIDMPTEEMKNIKPHKNNQFSDALVIENRHAKEEKNWPSGGQMTVKDLTAKYSEGGAAVLENISFSISSGQRVGLLGRTGSGKSTLLFAFLRLLNTEGDIQIDGVSWSTVSVQQWRKAFGVIPQKVFIFSGTFRMNLDPYGQWNDEEIWKVAEEVGLKSVIEQFPGQLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTSQVIRKTLKHAFANCTVILSEHRLEAMLECQRFLVIEDNKLRQYESIQKLLNEKSSFRQAISHADRLKLLPVHHRNSSKRKPRPKITALQEETEEEVQETRL'" ] }, { "cell_type": "code", "execution_count": 48, "metadata": {}, "outputs": [], "source": [ "res = c.function(mystery_seq)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "This returns a list of results. The first is of the form" ] }, { "cell_type": "code", "execution_count": 49, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "{'Aspect': 'F',\n", " 'Assigned_By': 'OMA_FastMap',\n", " 'DB': 'OMA_FastMap',\n", " 'DB:Reference': 'OMA_Fun:002',\n", " 'DB_Object_Name': '',\n", " 'DB_Object_Type': 'protein',\n", " 'Date': '20180807',\n", " 'Evidence': 'IEA',\n", " 'GO_ID': 'GO:0000166',\n", " 'GO_name': 'nucleotide binding',\n", " 'Qualifier': '',\n", " 'Synonym': '',\n", " 'With': 'Approx:TAEGU04269:11919.380438514474'}" ] }, "execution_count": 49, "metadata": {}, "output_type": "execute_result" } ], "source": [ "res[0]" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "All list-typed returns are possible to load as a pandas data frame (`pd.DataFrame`), instead. To do this, the following call can be made." ] }, { "cell_type": "code", "execution_count": 50, "metadata": {}, "outputs": [], "source": [ "df = c.function(mystery_seq, as_dataframe=True)" ] }, { "cell_type": "code", "execution_count": 51, "metadata": { "scrolled": true }, "outputs": [ { "data": { "text/html": [ "
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AspectAssigned_ByDBDB:ReferenceDB_Object_NameDB_Object_TypeDateEvidenceGO_IDGO_nameQualifierSynonymWith
0FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0000166nucleotide bindingApprox:TAEGU04269:11919.380438514474
1FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005254chloride channel activityApprox:TAEGU04269:11919.380438514474
2FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005260intracellularly ATP-gated chloride channel act...Approx:TAEGU04269:11919.380438514474
3FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005524ATP bindingApprox:TAEGU04269:11919.380438514474
4COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005737cytoplasmApprox:TAEGU04269:11919.380438514474
5COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005769early endosomeApprox:TAEGU04269:11919.380438514474
6COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005789endoplasmic reticulum membraneApprox:TAEGU04269:11919.380438514474
7COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005829cytosolApprox:TAEGU04269:11919.380438514474
8COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005886plasma membraneApprox:TAEGU04269:11919.380438514474
9COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005887integral component of plasma membraneApprox:TAEGU04269:11919.380438514474
10POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0006695cholesterol biosynthetic processApprox:TAEGU04269:11919.380438514474
11POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0006811ion transportApprox:TAEGU04269:11919.380438514474
12POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0006821chloride transportApprox:TAEGU04269:11919.380438514474
13POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0006904vesicle docking involved in exocytosisApprox:TAEGU04269:11919.380438514474
14COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0009986cell surfaceApprox:TAEGU04269:11919.380438514474
15FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0015106bicarbonate transmembrane transporter activityApprox:TAEGU04269:11919.380438514474
16FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0015108chloride transmembrane transporter activityApprox:TAEGU04269:11919.380438514474
17POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0015701bicarbonate transportApprox:TAEGU04269:11919.380438514474
18COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0016020membraneApprox:TAEGU04269:11919.380438514474
19COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0016021integral component of membraneApprox:TAEGU04269:11919.380438514474
20COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0016324apical plasma membraneApprox:TAEGU04269:11919.380438514474
21FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0016787hydrolase activityApprox:TAEGU04269:11919.380438514474
22FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0016887ATPase activityApprox:TAEGU04269:11919.380438514474
23FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0019869chloride channel inhibitor activityApprox:TAEGU04269:11919.380438514474
24FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0019899enzyme bindingApprox:TAEGU04269:11919.380438514474
25FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0030165PDZ domain bindingApprox:TAEGU04269:11919.380438514474
26POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0030301cholesterol transportApprox:TAEGU04269:11919.380438514474
27COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0031205endoplasmic reticulum Sec complexApprox:TAEGU04269:11919.380438514474
28COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0032991protein-containing complexApprox:TAEGU04269:11919.380438514474
29COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0034707chloride channel complexApprox:TAEGU04269:11919.380438514474
30POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0035377transepithelial water transportApprox:TAEGU04269:11919.380438514474
31POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0035774positive regulation of insulin secretion invol...Approx:TAEGU04269:11919.380438514474
32FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0042626ATPase activity, coupled to transmembrane move...Approx:TAEGU04269:11919.380438514474
33POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0045921positive regulation of exocytosisApprox:TAEGU04269:11919.380438514474
34POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0048240sperm capacitationApprox:TAEGU04269:11919.380438514474
35POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0050891multicellular organismal water homeostasisApprox:TAEGU04269:11919.380438514474
36FOMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0051087chaperone bindingApprox:TAEGU04269:11919.380438514474
37POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0051454intracellular pH elevationApprox:TAEGU04269:11919.380438514474
38COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0055037recycling endosomeApprox:TAEGU04269:11919.380438514474
39POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0055085transmembrane transportApprox:TAEGU04269:11919.380438514474
40POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0060081membrane hyperpolarizationApprox:TAEGU04269:11919.380438514474
41POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0071320cellular response to cAMPApprox:TAEGU04269:11919.380438514474
42POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:1902161positive regulation of cyclic nucleotide-gated...Approx:TAEGU04269:11919.380438514474
43POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:1902476chloride transmembrane transportApprox:TAEGU04269:11919.380438514474
44POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:1902943positive regulation of voltage-gated chloride ...Approx:TAEGU04269:11919.380438514474
45POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:1904322cellular response to forskolinApprox:TAEGU04269:11919.380438514474
46POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0000003reproductionApprox:TAEGU04269:11919.380438514474
47COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005634nucleusApprox:TAEGU04269:11919.380438514474
48COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005768endosomeApprox:TAEGU04269:11919.380438514474
49COMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0005783endoplasmic reticulumApprox:TAEGU04269:11919.380438514474
50POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0010243response to organonitrogen compoundApprox:TAEGU04269:11919.380438514474
51POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0035690cellular response to drugApprox:TAEGU04269:11919.380438514474
52POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0046677response to antibioticApprox:TAEGU04269:11919.380438514474
53POMA_FastMapOMA_FastMapOMA_Fun:002protein20180807IEAGO:0071407cellular response to organic cyclic compoundApprox:TAEGU04269:11919.380438514474
\n", "
" ], "text/plain": [ " Aspect Assigned_By DB DB:Reference DB_Object_Name \\\n", "0 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "1 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "2 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "3 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "4 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "5 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "6 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "7 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "8 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "9 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "10 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "11 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "12 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "13 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "14 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "15 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "16 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "17 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "18 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "19 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "20 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "21 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "22 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "23 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "24 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "25 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "26 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "27 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "28 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "29 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "30 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "31 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "32 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "33 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "34 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "35 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "36 F OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "37 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "38 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "39 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "40 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "41 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "42 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "43 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "44 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "45 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "46 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "47 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "48 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "49 C OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "50 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "51 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "52 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "53 P OMA_FastMap OMA_FastMap OMA_Fun:002 \n", "\n", " DB_Object_Type Date Evidence GO_ID \\\n", "0 protein 20180807 IEA GO:0000166 \n", "1 protein 20180807 IEA GO:0005254 \n", "2 protein 20180807 IEA GO:0005260 \n", "3 protein 20180807 IEA GO:0005524 \n", "4 protein 20180807 IEA GO:0005737 \n", "5 protein 20180807 IEA GO:0005769 \n", "6 protein 20180807 IEA GO:0005789 \n", "7 protein 20180807 IEA GO:0005829 \n", "8 protein 20180807 IEA GO:0005886 \n", "9 protein 20180807 IEA GO:0005887 \n", "10 protein 20180807 IEA GO:0006695 \n", "11 protein 20180807 IEA GO:0006811 \n", "12 protein 20180807 IEA GO:0006821 \n", "13 protein 20180807 IEA GO:0006904 \n", "14 protein 20180807 IEA GO:0009986 \n", "15 protein 20180807 IEA GO:0015106 \n", "16 protein 20180807 IEA GO:0015108 \n", "17 protein 20180807 IEA GO:0015701 \n", "18 protein 20180807 IEA GO:0016020 \n", "19 protein 20180807 IEA GO:0016021 \n", "20 protein 20180807 IEA GO:0016324 \n", "21 protein 20180807 IEA GO:0016787 \n", "22 protein 20180807 IEA GO:0016887 \n", "23 protein 20180807 IEA GO:0019869 \n", "24 protein 20180807 IEA GO:0019899 \n", "25 protein 20180807 IEA GO:0030165 \n", "26 protein 20180807 IEA GO:0030301 \n", "27 protein 20180807 IEA GO:0031205 \n", "28 protein 20180807 IEA GO:0032991 \n", "29 protein 20180807 IEA GO:0034707 \n", "30 protein 20180807 IEA GO:0035377 \n", "31 protein 20180807 IEA GO:0035774 \n", "32 protein 20180807 IEA GO:0042626 \n", "33 protein 20180807 IEA GO:0045921 \n", "34 protein 20180807 IEA GO:0048240 \n", "35 protein 20180807 IEA GO:0050891 \n", "36 protein 20180807 IEA GO:0051087 \n", "37 protein 20180807 IEA GO:0051454 \n", "38 protein 20180807 IEA GO:0055037 \n", "39 protein 20180807 IEA GO:0055085 \n", "40 protein 20180807 IEA GO:0060081 \n", "41 protein 20180807 IEA GO:0071320 \n", "42 protein 20180807 IEA GO:1902161 \n", "43 protein 20180807 IEA GO:1902476 \n", "44 protein 20180807 IEA GO:1902943 \n", "45 protein 20180807 IEA GO:1904322 \n", "46 protein 20180807 IEA GO:0000003 \n", "47 protein 20180807 IEA GO:0005634 \n", "48 protein 20180807 IEA GO:0005768 \n", "49 protein 20180807 IEA GO:0005783 \n", "50 protein 20180807 IEA GO:0010243 \n", "51 protein 20180807 IEA GO:0035690 \n", "52 protein 20180807 IEA GO:0046677 \n", "53 protein 20180807 IEA GO:0071407 \n", "\n", " GO_name Qualifier Synonym \\\n", "0 nucleotide binding \n", "1 chloride channel activity \n", "2 intracellularly ATP-gated chloride channel act... \n", "3 ATP binding \n", "4 cytoplasm \n", "5 early endosome \n", "6 endoplasmic reticulum membrane \n", "7 cytosol \n", "8 plasma membrane \n", "9 integral component of plasma membrane \n", "10 cholesterol biosynthetic process \n", "11 ion transport \n", "12 chloride transport \n", "13 vesicle docking involved in exocytosis \n", "14 cell surface \n", "15 bicarbonate transmembrane transporter activity \n", "16 chloride transmembrane transporter activity \n", "17 bicarbonate transport \n", "18 membrane \n", "19 integral component of membrane \n", "20 apical plasma membrane \n", "21 hydrolase activity \n", "22 ATPase activity \n", "23 chloride channel inhibitor activity \n", "24 enzyme binding \n", "25 PDZ domain binding \n", "26 cholesterol transport \n", "27 endoplasmic reticulum Sec complex \n", "28 protein-containing complex \n", "29 chloride channel complex \n", "30 transepithelial water transport \n", "31 positive regulation of insulin secretion invol... \n", "32 ATPase activity, coupled to transmembrane move... \n", "33 positive regulation of exocytosis \n", "34 sperm capacitation \n", "35 multicellular organismal water homeostasis \n", "36 chaperone binding \n", "37 intracellular pH elevation \n", "38 recycling endosome \n", "39 transmembrane transport \n", "40 membrane hyperpolarization \n", "41 cellular response to cAMP \n", "42 positive regulation of cyclic nucleotide-gated... \n", "43 chloride transmembrane transport \n", "44 positive regulation of voltage-gated chloride ... \n", "45 cellular response to forskolin \n", "46 reproduction \n", "47 nucleus \n", "48 endosome \n", "49 endoplasmic reticulum \n", "50 response to organonitrogen compound \n", "51 cellular response to drug \n", "52 response to antibiotic \n", "53 cellular response to organic cyclic compound \n", "\n", " With \n", "0 Approx:TAEGU04269:11919.380438514474 \n", "1 Approx:TAEGU04269:11919.380438514474 \n", "2 Approx:TAEGU04269:11919.380438514474 \n", "3 Approx:TAEGU04269:11919.380438514474 \n", "4 Approx:TAEGU04269:11919.380438514474 \n", "5 Approx:TAEGU04269:11919.380438514474 \n", "6 Approx:TAEGU04269:11919.380438514474 \n", "7 Approx:TAEGU04269:11919.380438514474 \n", "8 Approx:TAEGU04269:11919.380438514474 \n", "9 Approx:TAEGU04269:11919.380438514474 \n", "10 Approx:TAEGU04269:11919.380438514474 \n", "11 Approx:TAEGU04269:11919.380438514474 \n", "12 Approx:TAEGU04269:11919.380438514474 \n", "13 Approx:TAEGU04269:11919.380438514474 \n", "14 Approx:TAEGU04269:11919.380438514474 \n", "15 Approx:TAEGU04269:11919.380438514474 \n", "16 Approx:TAEGU04269:11919.380438514474 \n", "17 Approx:TAEGU04269:11919.380438514474 \n", "18 Approx:TAEGU04269:11919.380438514474 \n", "19 Approx:TAEGU04269:11919.380438514474 \n", "20 Approx:TAEGU04269:11919.380438514474 \n", "21 Approx:TAEGU04269:11919.380438514474 \n", "22 Approx:TAEGU04269:11919.380438514474 \n", "23 Approx:TAEGU04269:11919.380438514474 \n", "24 Approx:TAEGU04269:11919.380438514474 \n", "25 Approx:TAEGU04269:11919.380438514474 \n", "26 Approx:TAEGU04269:11919.380438514474 \n", "27 Approx:TAEGU04269:11919.380438514474 \n", "28 Approx:TAEGU04269:11919.380438514474 \n", "29 Approx:TAEGU04269:11919.380438514474 \n", "30 Approx:TAEGU04269:11919.380438514474 \n", "31 Approx:TAEGU04269:11919.380438514474 \n", "32 Approx:TAEGU04269:11919.380438514474 \n", "33 Approx:TAEGU04269:11919.380438514474 \n", "34 Approx:TAEGU04269:11919.380438514474 \n", "35 Approx:TAEGU04269:11919.380438514474 \n", "36 Approx:TAEGU04269:11919.380438514474 \n", "37 Approx:TAEGU04269:11919.380438514474 \n", "38 Approx:TAEGU04269:11919.380438514474 \n", "39 Approx:TAEGU04269:11919.380438514474 \n", "40 Approx:TAEGU04269:11919.380438514474 \n", "41 Approx:TAEGU04269:11919.380438514474 \n", "42 Approx:TAEGU04269:11919.380438514474 \n", "43 Approx:TAEGU04269:11919.380438514474 \n", "44 Approx:TAEGU04269:11919.380438514474 \n", "45 Approx:TAEGU04269:11919.380438514474 \n", "46 Approx:TAEGU04269:11919.380438514474 \n", "47 Approx:TAEGU04269:11919.380438514474 \n", "48 Approx:TAEGU04269:11919.380438514474 \n", "49 Approx:TAEGU04269:11919.380438514474 \n", "50 Approx:TAEGU04269:11919.380438514474 \n", "51 Approx:TAEGU04269:11919.380438514474 \n", "52 Approx:TAEGU04269:11919.380438514474 \n", "53 Approx:TAEGU04269:11919.380438514474 " ] }, "execution_count": 51, "metadata": {}, "output_type": "execute_result" } ], "source": [ "df" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "This results in 54 GO annotations. By comparison, this sequence has merely 15 GO annotations in UniProt-GOA — all of which are also predicted by this method in OMA." ] } ], "metadata": { "kernelspec": { "display_name": "Python 3", "language": "python", "name": "python3" }, "language_info": { "codemirror_mode": { "name": "ipython", "version": 3 }, "file_extension": ".py", "mimetype": "text/x-python", "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", "version": "3.6.7" } }, "nbformat": 4, "nbformat_minor": 2 }