Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
type: Ontology
modelstate: production
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

excitatory postsynaptic potential
x: 455.75
y: 1100.500015258789
RO_0002213: membrane depolarization
type: NamedIndividual
type: GO_0060079
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

chemical synaptic transmission
x: 452.75
y: 1283.75
RO_0002213: excitatory postsynaptic potential
type: NamedIndividual
type: GO_0007268
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

chloride
x: 153.88333129882812
y: 1495.2499389648438
RO_0002352: GABA-gated chloride ion channel activity
type: NamedIndividual
type: CHEBI_17996
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

GABA-gated chloride ion channel activity
x: 460.75
y: 1465.9999542236328
RO_0002213: chemical synaptic transmission
type: NamedIndividual
type: GO_0022851
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

GABA receptor binding
x: 665.625
y: 1606.25
RO_0002212: GABA-gated chloride ion channel activity
type: NamedIndividual
type: GO_0050811
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

gamma-aminobutyric acid receptor subunit alpha-1
x: 820.5
y: 1746.4999389648438
RO_0002352: GABA receptor binding
type: NamedIndividual
type: PR_000007766
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

gamma-aminobutyric acid receptor subunit alpha-5
x: 560.75
y: 1747.4999389648438
RO_0002352: GABA receptor binding
type: NamedIndividual
type: PR_000007770
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

gamma-aminobutyric acid receptor subunit alpha-6
x: 296
y: 1723.4999389648438
RO_0002352: GABA receptor binding
type: NamedIndividual
type: PR_000007771
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

membrane depolarization
x: 457.75
y: 942.25
RO_0002213: seizures
type: NamedIndividual
type: GO_0051899
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

seizures
x: 454.75
y: 821
type: NamedIndividual
type: NBO_0000025
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22

Axiom
annotated property: RO_0002352
annotated source: chloride
annotated target: GABA-gated chloride ion channel activity
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-10-18

Axiom
annotated property: RO_0002212
annotated source: GABA receptor binding
annotated target: GABA-gated chloride ion channel activity
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-09-19

Axiom
annotated property: RO_0002213
annotated source: GABA-gated chloride ion channel activity
annotated target: chemical synaptic transmission
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-09-19

Axiom
annotated property: RO_0002213
annotated source: chemical synaptic transmission
annotated target: excitatory postsynaptic potential
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-09-19

Axiom
annotated property: RO_0002213
annotated source: excitatory postsynaptic potential
annotated target: membrane depolarization
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-09-19

Axiom
annotated property: RO_0002352
annotated source: gamma-aminobutyric acid receptor subunit alpha-1
annotated target: GABA receptor binding
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-10-18

Axiom
annotated property: RO_0002352
annotated source: gamma-aminobutyric acid receptor subunit alpha-5
annotated target: GABA receptor binding
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-10-18

Axiom
annotated property: RO_0002352
annotated source: gamma-aminobutyric acid receptor subunit alpha-6
annotated target: GABA receptor binding
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-10-18

Axiom
annotated property: RO_0002213
annotated source: membrane depolarization
annotated target: seizures
contributor: https://orcid.org/0000-0001-9356-3475
date: 2023-11-22