format-version: 1.2
data-version: fbcv/releases/2024-02-23
date: 23:02:2024 09:19
subsetdef: 1_STAR ""
subsetdef: 2_STAR ""
subsetdef: 3_STAR ""
subsetdef: abnormal_slim "Abnormal/normal slim"
subsetdef: absent_slim "Absent/present slim"
subsetdef: attribute_slim "Attribute slim"
subsetdef: camcur ""
subsetdef: camcur "camcur"
subsetdef: cell_quality "cell_quality"
subsetdef: common_tool_use "Terms to summarize typical use of a gene from one organism that is introduced into another organism primarily for use an experimental tool, rather than to study the function of the gene"
subsetdef: cur "cur"
subsetdef: deprecated "warning of impending obsoletion"
subsetdef: do_not_annotate "Term not to be used for direct annotation"
subsetdef: do_not_manually_annotate "Term not to be used for direct manual annotation"
subsetdef: EmbDevSlim "EmbDevSlim"
subsetdef: fbcvsubset_mgiribbons "MGI ribbon terms"
subsetdef: FlyTed "Testis slim"
subsetdef: FT_new "FlyTed temp subset for edit tracking purposes"
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam ""
subsetdef: larval_OF "larval olfactory system"
subsetdef: lethal_phase "lethal phase terms"
subsetdef: RD "terms for rd test ontology"
subsetdef: relational_slim "Relational slim: types of quality that require an additional entity in order to exist"
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: value_slim "Value slim"
synonymtypedef: BRAIN_NAME_ABV "BrainName official abbreviation"
synonymtypedef: BRAND_NAME ""
synonymtypedef: BRAND_NAME "BRAND NAME"
synonymtypedef: FORMULA "FORMULA"
synonymtypedef: InChI "InChI"
synonymtypedef: InChIKey "InChIKey"
synonymtypedef: INN ""
synonymtypedef: INN "INN"
synonymtypedef: IUPAC_NAME ""
synonymtypedef: IUPAC_NAME "IUPAC NAME"
synonymtypedef: SMILES "SMILES"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: FlyBase miscellaneous CV
ontology: fbcv.obo
property_value: attributionURL "http://dx.doi.org/10.1186/2041-1480-4-30" xsd:string
property_value: http://purl.org/dc/elements/1.1/creator "http://orcid.org/0000-0002-1373-1705" xsd:string
property_value: http://purl.org/dc/elements/1.1/creator "http://orcid.org/0000-0002-7073-9172" xsd:string
property_value: http://purl.org/dc/elements/1.1/creator "https://orcid.org/0000-0001-5948-3092" xsd:string
property_value: http://purl.org/dc/elements/1.1/creator "https://orcid.org/0000-0002-0027-0858" xsd:string
property_value: http://purl.org/dc/elements/1.1/description "A miscellaneous ontology of terms used for curation in FlyBase, including the DPO." xsd:string
property_value: http://purl.org/dc/elements/1.1/title "FlyBase Controlled Vocabulary (FBcv)" xsd:string
property_value: http://purl.org/dc/terms/license "https://creativecommons.org/licenses/by/4.0/" xsd:string
property_value: IAO:0000700 FBcv:0000000
property_value: owl:versionInfo "2024-02-23" xsd:string

[Term]
id: BFO:0000002
name: continuant
def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []
disjoint_from: BFO:0000003 ! occurrent
relationship: BFO:0000050 BFO:0000002 {all_only="true"} ! part of continuant

[Term]
id: BFO:0000003
name: occurrent
def: "An entity that has temporal parts and that happens, unfolds or develops through time." []
relationship: BFO:0000050 BFO:0000003 {all_only="true"} ! part of occurrent

[Term]
id: BFO:0000004
name: independent continuant
def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" []
comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: BFO:0000050 BFO:0000004 {all_only="true"} ! part of independent continuant

[Term]
id: BFO:0000015
name: process
def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" []
comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
is_a: BFO:0000003 ! occurrent

[Term]
id: BFO:0000016
name: disposition
is_a: BFO:0000017 ! realizable entity
disjoint_from: BFO:0000023 ! role

[Term]
id: BFO:0000017
name: realizable entity
def: "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." []
is_a: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000019 ! quality
relationship: BFO:0000050 BFO:0000017 {all_only="true"} ! part of realizable entity

[Term]
id: BFO:0000019
name: quality
is_a: BFO:0000020 ! specifically dependent continuant
relationship: BFO:0000050 BFO:0000019 {all_only="true"} ! part of quality

[Term]
id: BFO:0000020
name: specifically dependent continuant
def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" []
comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: BFO:0000050 BFO:0000020 {all_only="true"} ! part of specifically dependent continuant

[Term]
id: BFO:0000023
name: role
def: "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts." []
is_a: BFO:0000017 ! realizable entity

[Term]
id: BFO:0000031
name: generically dependent continuant
def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" []
comment: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
is_a: BFO:0000002 ! continuant
relationship: BFO:0000050 BFO:0000031 {all_only="true"} ! part of generically dependent continuant

[Term]
id: BFO:0000034
name: function
is_a: BFO:0000016 ! disposition

[Term]
id: BFO:0000040
name: material entity
def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
is_a: BFO:0000004 ! independent continuant

[Term]
id: CHEBI:10432
name: 2-naphthol
namespace: chebi_ontology
def: "A naphthol carrying a hydroxy group at position 2." []
subset: 3_STAR
synonym: "2-hydroxynaphthalene" RELATED [HMDB]
synonym: "2-Naftol" RELATED [ChemIDplus]
synonym: "2-naftolo" RELATED [ChemIDplus]
synonym: "2-naphthalenol" RELATED [NIST_Chemistry_WebBook]
synonym: "2-Naphthol" EXACT [KEGG_COMPOUND]
synonym: "2-naphthol" EXACT [UniProt]
synonym: "2-naphtol" RELATED [ChemIDplus]
synonym: "Antioxygene BN" RELATED BRAND_NAME [HMDB]
synonym: "Azogen Developer A" RELATED BRAND_NAME [HMDB]
synonym: "beta-hydroxynaphthalene" RELATED [NIST_Chemistry_WebBook]
synonym: "beta-hydroxynaphthalene" RELATED [ChemIDplus]
synonym: "beta-Naftol" RELATED [ChemIDplus]
synonym: "beta-naftolo" RELATED [ChemIDplus]
synonym: "beta-Naphthol" RELATED [KEGG_COMPOUND]
synonym: "beta-naphthol" RELATED [NIST_Chemistry_WebBook]
synonym: "beta-naphthyl alcohol" RELATED [ChemIDplus]
synonym: "beta-naphthyl hydroxide" RELATED [ChemIDplus]
synonym: "beta-Naphtol" RELATED [ChemIDplus]
synonym: "C.I. Azoic Coupling Component 1" RELATED BRAND_NAME [ChemIDplus]
synonym: "C.I. Developer 5" RELATED BRAND_NAME [ChemIDplus]
synonym: "Developer A" RELATED BRAND_NAME [ChemIDplus]
synonym: "Developer AMS" RELATED BRAND_NAME [ChemIDplus]
synonym: "Developer BN" RELATED BRAND_NAME [ChemIDplus]
synonym: "Isonaphthol" RELATED [ChemIDplus]
synonym: "naphthalen-2-ol" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:742134 {source="Beilstein"}
xref: CAS:135-19-3 {source="NIST Chemistry WebBook"}
xref: CAS:135-19-3 {source="ChemIDplus"}
xref: CAS:135-19-3 {source="KEGG COMPOUND"}
xref: Drug_Central:3370 {source="DrugCentral"}
xref: FooDB:FDB000877
xref: Gmelin:27395 {source="Gmelin"}
xref: HMDB:HMDB0012322
xref: KEGG:C11713
xref: MetaCyc:CPD-8131
xref: PDBeChem:03V
xref: PMID:13386410 {source="Europe PMC"}
xref: PMID:14751800 {source="Europe PMC"}
xref: PMID:18515997 {source="Europe PMC"}
xref: PMID:18856458 {source="Europe PMC"}
xref: PMID:20260560 {source="Europe PMC"}
xref: PMID:22069470 {source="Europe PMC"}
xref: PMID:22740618 {source="Europe PMC"}
xref: PMID:23344974 {source="Europe PMC"}
xref: PMID:29987264 {source="Europe PMC"}
xref: PMID:30572877 {source="Europe PMC"}
xref: PMID:30828382 {source="Europe PMC"}
xref: PMID:32206945 {source="Europe PMC"}
xref: PMID:33862438 {source="Europe PMC"}
xref: PMID:34033865 {source="Europe PMC"}
xref: Reaxys:742134 {source="Reaxys"}
xref: Wikipedia:2-Naphthol
is_a: CHEBI:35682 ! naphthol
relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug
relationship: RO:0000087 CHEBI:48578 ! has role radical scavenger
relationship: RO:0000087 CHEBI:50902 ! has role genotoxin
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H8O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H8O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JWAZRIHNYRIHIV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "144.173" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "144.05751" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC1=CC2=CC=CC=C2C=C1" xsd:string

[Term]
id: CHEBI:10545
name: electron
namespace: chebi_ontology
def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." []
subset: 3_STAR
synonym: "beta" RELATED [IUPAC]
synonym: "beta(-)" RELATED [ChEBI]
synonym: "beta-particle" RELATED [IUPAC]
synonym: "e" RELATED [IUPAC]
synonym: "e(-)" RELATED [UniProt]
synonym: "e-" RELATED [KEGG_COMPOUND]
synonym: "electron" EXACT [KEGG_COMPOUND]
synonym: "electron" EXACT IUPAC_NAME [IUPAC]
synonym: "electron" EXACT [ChEBI]
synonym: "Elektron" RELATED [ChEBI]
synonym: "negatron" RELATED [IUPAC]
xref: KEGG:C05359
xref: PMID:21614077 {source="Europe PMC"}
xref: Wikipedia:Electron
is_a: CHEBI:36338 ! lepton
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.000548579903" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string

[Term]
id: CHEBI:131927
name: dicarboxylic acids and O-substituted derivatives
namespace: chebi_ontology
def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." []
subset: 3_STAR
synonym: "dicarboxylic acids and derivatives" RELATED [ChEBI]
is_a: CHEBI:36586 ! carbonyl compound

[Term]
id: CHEBI:132124
name: 1,4-benzoquinones
namespace: chebi_ontology
def: "Any member of the class of benzoquinones that is 1,4-benzoquinone or its C-substituted derivatives." []
subset: 3_STAR
synonym: "a quinone" RELATED [UniProt]
synonym: "p-benzoquinones" RELATED [ChEBI]
synonym: "para-benzoquinones" RELATED [ChEBI]
is_a: CHEBI:22729 ! benzoquinones
is_a: CHEBI:25830 ! p-quinones
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6O2R4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "104.063" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "103.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1C(*)=C(*)C(=O)C(*)=C1*" xsd:string

[Term]
id: CHEBI:134179
name: volatile organic compound
namespace: chebi_ontology
def: "Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa." []
subset: 3_STAR
synonym: "VOC" RELATED [ChEBI]
synonym: "VOCs" RELATED [ChEBI]
synonym: "volatile organic compounds" RELATED [ChEBI]
xref: Wikipedia:Volatile_organic_compound
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:134249
name: alkanesulfonate oxoanion
namespace: chebi_ontology
alt_id: CHEBI:22318
def: "An alkanesulfonate in which the carbon at position 1 is attached to R, which can represent hydrogens, a carbon chain, or other groups." []
subset: 3_STAR
synonym: "alkanesulfonate oxoanions" RELATED [ChEBI]
synonym: "alkanesulfonates" RELATED [ChEBI]
synonym: "an alkanesulfonate" RELATED [UniProt]
xref: MetaCyc:Alkanesulfonates
is_a: CHEBI:33554 ! organosulfonate oxoanion
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O3SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "94.091" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "93.97246" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(S([O-])(=O)=O)*" xsd:string

[Term]
id: CHEBI:13643
name: glycol
namespace: chebi_ontology
def: "A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." []
subset: 3_STAR
synonym: "glycols" EXACT IUPAC_NAME [IUPAC]
synonym: "Glykol" RELATED [ChEBI]
is_a: CHEBI:23824 ! diol

[Term]
id: CHEBI:136859
name: pro-agent
namespace: chebi_ontology
def: "A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent." []
subset: 3_STAR
synonym: "pro-agents" RELATED [ChEBI]
synonym: "proagent" RELATED [ChEBI]
synonym: "proagents" RELATED [ChEBI]
xref: PMID:26449612 {source="Europe PMC"}
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:137980
name: metalloid atom
namespace: chebi_ontology
def: "An atom of an element that exhibits properties that are between those of metals and nonmetals, or that has a mixture of them. The term generally includes boron, silicon, germanium, arsenic, antimony, and tellurium, while carbon, aluminium, selenium, polonium, and astatine are less commonly included." []
subset: 3_STAR
synonym: "metalloid" RELATED [ChEBI]
synonym: "metalloids" RELATED [ChEBI]
xref: Wikipedia:Metalloid
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:137982
name: tertiary ammonium ion
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the amino group of any tertiary amino compound." []
subset: 3_STAR
synonym: "a tertiary amine" RELATED [UniProt]
synonym: "tertiary amine(1+)" RELATED [ChEBI]
synonym: "tertiary ammonium ions" RELATED [ChEBI]
is_a: CHEBI:25697 ! organic cation
relationship: is_conjugate_acid_of CHEBI:50996 ! tertiary amino compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HNR3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.015" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01090" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH+](*)(*)*" xsd:string

[Term]
id: CHEBI:138015
name: endocrine disruptor
namespace: chebi_ontology
def: "Any compound that can disrupt the functions of the endocrine (hormone) system" []
subset: 3_STAR
synonym: "endocrine disrupting chemical" RELATED [ChEBI]
synonym: "endocrine disrupting chemicals" RELATED [ChEBI]
synonym: "endocrine disrupting compound" RELATED [ChEBI]
synonym: "endocrine disrupting compounds" RELATED [ChEBI]
synonym: "endocrine disruptors" RELATED [ChEBI]
synonym: "endocrine-disrupting chemical" RELATED [ChEBI]
synonym: "endocrine-disrupting chemicals" RELATED [ChEBI]
synonym: "hormonally active agent" RELATED [ChEBI]
synonym: "hormonally active agents" RELATED [ChEBI]
xref: PMID:27929035 {source="Europe PMC"}
xref: PMID:28356401 {source="Europe PMC"}
xref: PMID:28526231 {source="Europe PMC"}
xref: Wikipedia:Endocrine_disruptor
is_a: CHEBI:51061 ! hormone receptor modulator

[Term]
id: CHEBI:138103
name: inorganic acid
namespace: chebi_ontology
def: "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." []
subset: 3_STAR
synonym: "inorganic acids" RELATED [ChEBI]
synonym: "mineral acid" RELATED [ChEBI]
synonym: "mineral acids" RELATED [ChEBI]
xref: Wikipedia:Mineral_acid
is_a: CHEBI:39141 ! Bronsted acid

[Term]
id: CHEBI:138675
name: gas molecular entity
namespace: chebi_ontology
def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." []
subset: 3_STAR
synonym: "gas molecular entities" RELATED [ChEBI]
synonym: "gaseous molecular entities" RELATED [ChEBI]
synonym: "gaseous molecular entity" RELATED [ChEBI]
xref: Wikipedia:https\://en.wikipedia.org/wiki/Gas
is_a: CHEBI:33579 ! main group molecular entity

[Term]
id: CHEBI:139358
name: isotopically modified compound
namespace: chebi_ontology
def: "Any molecular entity in which the isotopic ratio of nuclides for at least one element deviates measurably from that occurring in nature. The term includes both isotopically substituted compounds (in which essentially all the molecules of the compound have only the indicated nuclide(s) at each designated position) and isotopically labeled compounds (a formal mixture of an isotopically unmodified compound with one or more analogous isotopically substituted compound(s)." []
subset: 3_STAR
synonym: "isotopically modified compounds" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:139359
name: tritiated compound
namespace: chebi_ontology
def: "Any isotopically modified compound that has one or more hydrogens replaced by tritium." []
subset: 3_STAR
synonym: "(3)H-labeled compound" RELATED [ChEBI]
synonym: "(3)H-labeled compounds" RELATED [ChEBI]
synonym: "(3)H-labelled compound" RELATED [ChEBI]
synonym: "(3)H-labelled compounds" RELATED [ChEBI]
synonym: "tritiated compounds" RELATED [ChEBI]
synonym: "tritium-labeled compound" RELATED [ChEBI]
synonym: "tritium-labeled compounds" RELATED [ChEBI]
synonym: "tritium-labelled compound" RELATED [ChEBI]
synonym: "tritium-labelled compounds" RELATED [ChEBI]
is_a: CHEBI:139358 ! isotopically modified compound

[Term]
id: CHEBI:13941
name: carbamate
namespace: chebi_ontology
subset: 3_STAR
synonym: "Carbamat" RELATED [ChEBI]
synonym: "carbamate" EXACT [UniProt]
synonym: "carbamate" EXACT IUPAC_NAME [IUPAC]
synonym: "carbamate ion" RELATED [ChemIDplus]
synonym: "carbamic acid, ion(1-)" RELATED [ChemIDplus]
synonym: "Karbamat" RELATED [ChEBI]
xref: Beilstein:3903503 {source="Beilstein"}
xref: CAS:302-11-4 {source="ChemIDplus"}
xref: Gmelin:239604 {source="Gmelin"}
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.03212" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.00910" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([O-])=O" xsd:string

[Term]
id: CHEBI:139492
name: sensitiser
namespace: chebi_ontology
def: "A chemical compound that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the compound." []
subset: 3_STAR
synonym: "sensitisers" RELATED [ChEBI]
synonym: "sensitizer" RELATED [ChEBI]
synonym: "sensitizers" RELATED [ChEBI]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:139520
name: phenolic donor
namespace: chebi_ontology
def: "Any phenol that acts as an electron donor." []
subset: 3_STAR
synonym: "a phenolic donor" RELATED [UniProt]
synonym: "phenolic donors" RELATED [ChEBI]
xref: MetaCyc:Phenolic-Donors
xref: PMID:16098794 {source="Europe PMC"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33853 ! phenols
relationship: RO:0000087 CHEBI:15022 ! has role electron donor
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H5OR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "93.104" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "93.03404" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC1=CC=C([*])C=C1" xsd:string

[Term]
id: CHEBI:140332
name: 4'-methoxyflavanones
namespace: chebi_ontology
def: "Any methoxyflavanone having a methoxy substituent located at position 4'." []
subset: 3_STAR
synonym: "2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one" EXACT IUPAC_NAME [IUPAC]
synonym: "a 4'-methoxyflavanone" RELATED [UniProt]
xref: MetaCyc:4-Methoxyflavanones {source="SUBMITTER"}
is_a: CHEBI:25240 ! methoxyflavanone
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H5O3R9" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "245.210" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "245.02387" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=C(C(=C(C2=C1OC(C(C2=O)*)C3=C(C(=C(C(=C3*)*)OC)*)*)*)*)*)*" xsd:string

[Term]
id: CHEBI:14321
name: glutamate(1-)
namespace: chebi_ontology
def: "An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group" []
subset: 3_STAR
synonym: "2-ammoniopentanedioate" RELATED [IUPAC]
synonym: "glutamate" RELATED [UniProt]
synonym: "glutamate(1-)" EXACT [JCBN]
synonym: "glutamic acid monoanion" RELATED [JCBN]
synonym: "hydrogen glutamate" EXACT IUPAC_NAME [IUPAC]
xref: Gmelin:327908 {source="Gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: is_conjugate_acid_of CHEBI:29987 ! glutamate(2-)
relationship: is_conjugate_base_of CHEBI:18237 ! glutamic acid
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "146.12136" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "146.04588" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CCC([O-])=O)C([O-])=O" xsd:string

[Term]
id: CHEBI:149552
name: emetic
namespace: chebi_ontology
def: "Any agent that induces nausea and vomiting." []
subset: 3_STAR
synonym: "emetics" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:15022
name: electron donor
namespace: chebi_ontology
def: "A molecular entity that can transfer an electron to another molecular entity." []
subset: 3_STAR
synonym: "donneur d'electron" RELATED [IUPAC]
synonym: "electron donor" EXACT IUPAC_NAME [IUPAC]
synonym: "Elektronendonator" RELATED [ChEBI]
is_a: CHEBI:17891 ! donor

[Term]
id: CHEBI:15318
name: xanthine
namespace: chebi_ontology
def: "A purine nucleobase found in humans and other organisms." []
subset: 3_STAR
synonym: "2,6-dioxopurine" RELATED [ChEBI]
synonym: "2,6-dioxopurines" RELATED [ChEBI]
synonym: "xanthine" EXACT [ChEBI]
synonym: "xanthines" RELATED [ChEBI]
xref: ECMDB:ECMDB00292
xref: KNApSAcK:C00019660
xref: PMID:1557408 {source="Europe PMC"}
xref: PMID:24629268 {source="Europe PMC"}
xref: PMID:9007687 {source="Europe PMC"}
xref: YMDB:YMDB00263
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25810 ! oxopurine
is_a: CHEBI:26386 ! purine nucleobase
relationship: has_functional_parent CHEBI:16235 ! guanine
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "152.111" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "152.03343" xsd:string

[Term]
id: CHEBI:15339
name: acceptor
namespace: chebi_ontology
alt_id: CHEBI:13699
alt_id: CHEBI:2377
def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." []
subset: 3_STAR
synonym: "A" RELATED [KEGG_COMPOUND]
synonym: "accepteur" RELATED [ChEBI]
synonym: "Acceptor" EXACT [KEGG_COMPOUND]
synonym: "Akzeptor" RELATED [ChEBI]
synonym: "Hydrogen-acceptor" RELATED [KEGG_COMPOUND]
synonym: "Oxidized donor" RELATED [KEGG_COMPOUND]
xref: KEGG:C00028
xref: KEGG:C16722
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:15356
name: cysteine
namespace: chebi_ontology
alt_id: CHEBI:14061
alt_id: CHEBI:23508
alt_id: CHEBI:4050
def: "A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3." []
subset: 3_STAR
synonym: "2-amino-3-mercaptopropanoic acid" RELATED [JCBN]
synonym: "2-Amino-3-mercaptopropionic acid" RELATED [KEGG_COMPOUND]
synonym: "2-amino-3-sulfanylpropanoic acid" RELATED [IUPAC]
synonym: "C" RELATED [ChEBI]
synonym: "cisteina" RELATED [ChEBI]
synonym: "Cys" RELATED [ChEBI]
synonym: "Cystein" RELATED [ChEBI]
synonym: "Cysteine" EXACT [KEGG_COMPOUND]
synonym: "cysteine" EXACT IUPAC_NAME [IUPAC]
synonym: "cysteine" EXACT [ChEBI]
synonym: "Hcys" RELATED [IUPAC]
synonym: "Zystein" RELATED [ChEBI]
xref: Beilstein:1721406 {source="Beilstein"}
xref: CAS:3374-22-9 {source="ChemIDplus"}
xref: CAS:3374-22-9 {source="NIST Chemistry WebBook"}
xref: CAS:3374-22-9 {source="KEGG COMPOUND"}
xref: Gmelin:2933 {source="Gmelin"}
xref: KEGG:C00736
xref: KNApSAcK:C00001351
xref: KNApSAcK:C00007323
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:25181601 {source="Europe PMC"}
xref: Reaxys:1721406 {source="Reaxys"}
xref: Wikipedia:Cysteine
is_a: CHEBI:26167 ! polar amino acid
is_a: CHEBI:26834 ! sulfur-containing amino acid
is_a: CHEBI:33704 ! alpha-amino acid
relationship: BFO:0000051 CHEBI:50326 ! has part sulfanylmethyl group
relationship: is_conjugate_acid_of CHEBI:32456 ! cysteinate(1-)
relationship: is_conjugate_base_of CHEBI:32458 ! cysteinium
relationship: is_tautomer_of CHEBI:35237 ! cysteine zwitterion
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7NO2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "121.15922" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "121.01975" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CS)C(O)=O" xsd:string

[Term]
id: CHEBI:15369
name: actinomycin
namespace: chebi_ontology
alt_id: CHEBI:13723
alt_id: CHEBI:22220
alt_id: CHEBI:2445
def: "A large group of antibiotics isolated from various species of Streptomyces and characterised by having a substituted phenoxazine ring linked to two cyclic heterodetic peptides." []
subset: 3_STAR
synonym: "Actinomycin" EXACT [KEGG_COMPOUND]
synonym: "actinomycins" RELATED [ChEBI]
xref: CAS:1402-38-6 {source="KEGG COMPOUND"}
xref: CAS:1402-38-6 {source="ChemIDplus"}
xref: KEGG:C01775
is_a: CHEBI:23239 ! chromopeptide

[Term]
id: CHEBI:15378
name: hydron
namespace: chebi_ontology
alt_id: CHEBI:10744
alt_id: CHEBI:13357
alt_id: CHEBI:5584
def: "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes)." []
subset: 3_STAR
synonym: "H(+)" RELATED [UniProt]
synonym: "H+" RELATED [KEGG_COMPOUND]
synonym: "hydrogen(1+)" EXACT IUPAC_NAME [IUPAC]
synonym: "Hydron" EXACT [KEGG_COMPOUND]
synonym: "hydron" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00080
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33251 ! monoatomic hydrogen
is_a: CHEBI:33252 ! atomic nucleus
is_a: CHEBI:60242 ! monovalent inorganic cation
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GPRLSGONYQIRFK-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "1.00794" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.008" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H+]" xsd:string

[Term]
id: CHEBI:15705
name: L-alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:13072
alt_id: CHEBI:13243
alt_id: CHEBI:13797
alt_id: CHEBI:21224
alt_id: CHEBI:6175
def: "Any alpha-amino acid having L-configuration at the alpha-carbon." []
subset: 3_STAR
synonym: "L-2-Amino acid" RELATED [KEGG_COMPOUND]
synonym: "L-alpha-amino acid" EXACT [IUPAC]
synonym: "L-alpha-amino acids" EXACT IUPAC_NAME [IUPAC]
synonym: "L-alpha-amino acids" RELATED [ChEBI]
synonym: "L-Amino acid" RELATED [KEGG_COMPOUND]
xref: KEGG:C00151
is_a: CHEBI:33704 ! alpha-amino acid
relationship: is_conjugate_acid_of CHEBI:59814 ! L-alpha-amino acid anion
relationship: is_tautomer_of CHEBI:59869 ! L-alpha-amino acid zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H]([*])C(O)=O" xsd:string

[Term]
id: CHEBI:15740
name: formate
namespace: chebi_ontology
alt_id: CHEBI:14276
alt_id: CHEBI:24081
def: "A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects." []
subset: 3_STAR
synonym: "aminate" RELATED [ChEBI]
synonym: "formate" EXACT IUPAC_NAME [IUPAC]
synonym: "formate" EXACT [UniProt]
synonym: "formiate" RELATED [ChEBI]
synonym: "formic acid, ion(1-)" RELATED [ChemIDplus]
synonym: "formylate" RELATED [ChEBI]
synonym: "HCO2 anion" RELATED [NIST_Chemistry_WebBook]
synonym: "hydrogen carboxylate" RELATED [ChEBI]
synonym: "methanoate" RELATED [ChEBI]
xref: Beilstein:1901205 {source="Beilstein"}
xref: CAS:71-47-6 {source="ChemIDplus"}
xref: CAS:71-47-6 {source="NIST Chemistry WebBook"}
xref: Gmelin:1006 {source="Gmelin"}
xref: HMDB:HMDB0000142
xref: KEGG:C00058
xref: MetaCyc:FORMATE
xref: PMID:17190852 {source="Europe PMC"}
xref: PMID:3946945 {source="Europe PMC"}
xref: Reaxys:1901205 {source="Reaxys"}
xref: UM-BBD_compID:c0106 {source="UM-BBD"}
xref: Wikipedia:Formate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: is_conjugate_base_of CHEBI:30751 ! formic acid
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDAGIHXWWSANSR-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01744" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99820" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([O-])=O" xsd:string

[Term]
id: CHEBI:15778
name: N-acyl-D-amino acid
namespace: chebi_ontology
alt_id: CHEBI:12474
alt_id: CHEBI:21631
alt_id: CHEBI:7224
def: "Any N-acyl-amino acid in which the amino acid moiety has D configuration." []
subset: 3_STAR
is_a: CHEBI:51569 ! N-acyl-amino acid
is_a: CHEBI:83812 ! non-proteinogenic amino acid derivative
relationship: is_conjugate_acid_of CHEBI:59876 ! N-acyl-D-alpha-amino acid anion
relationship: is_enantiomer_of CHEBI:21644 ! N-acyl-L-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H3NO3R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "101.06080" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.01129" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)[C@@H]([*])NC([*])=O" xsd:string

[Term]
id: CHEBI:15966
name: D-glutamic acid
namespace: chebi_ontology
alt_id: CHEBI:21023
alt_id: CHEBI:4183
def: "An optically active form of glutamic acid having D-configuration." []
subset: 3_STAR
synonym: "(2R)-2-aminopentanedioic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "(R)-2-aminopentanedioic acid" RELATED [ChEBI]
synonym: "D-2-Aminoglutaric acid" RELATED [KEGG_COMPOUND]
synonym: "D-Glutamic acid" EXACT [KEGG_COMPOUND]
synonym: "D-glutamic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "D-Glutaminic acid" RELATED [KEGG_COMPOUND]
synonym: "D-Glutaminsaeure" RELATED [ChEBI]
synonym: "DGL" RELATED [PDBeChem]
synonym: "glutamic acid D-form" RELATED [ChemIDplus]
xref: Beilstein:1723800 {source="Beilstein"}
xref: CAS:6893-26-1 {source="NIST Chemistry WebBook"}
xref: CAS:6893-26-1 {source="ChemIDplus"}
xref: CAS:6893-26-1 {source="KEGG COMPOUND"}
xref: DrugBank:DB02517
xref: Gmelin:201189 {source="Gmelin"}
xref: HMDB:HMDB0003339
xref: KEGG:C00217
xref: KNApSAcK:C00019577
xref: MetaCyc:D-GLT
xref: PDBeChem:DGL
xref: Reaxys:1723800 {source="Reaxys"}
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:18237 ! glutamic acid
relationship: is_conjugate_acid_of CHEBI:29986 ! D-glutamate(1-)
relationship: is_enantiomer_of CHEBI:16015 ! L-glutamic acid
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-GSVOUGTGSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "147.12930" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "147.05316" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H](CCC(O)=O)C(O)=O" xsd:string

[Term]
id: CHEBI:15986
name: polynucleotide
namespace: chebi_ontology
alt_id: CHEBI:13672
alt_id: CHEBI:14859
alt_id: CHEBI:8312
def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." []
subset: 3_STAR
synonym: "Polynucleotide" EXACT [KEGG_COMPOUND]
synonym: "polynucleotides" RELATED [ChEBI]
xref: KEGG:C00419
is_a: CHEBI:33695 ! information biomacromolecule
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: BFO:0000051 CHEBI:50319 ! has part nucleotide residue
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "(C5H8O6PR)n.C10H17O10PR2" xsd:string

[Term]
id: CHEBI:16015
name: L-glutamic acid
namespace: chebi_ontology
alt_id: CHEBI:21304
alt_id: CHEBI:42825
alt_id: CHEBI:6224
def: "An optically active form of glutamic acid having L-configuration." []
subset: 3_STAR
synonym: "(2S)-2-aminopentanedioic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "(S)-2-aminopentanedioic acid" RELATED [ChEBI]
synonym: "(S)-glutamic acid" RELATED [NIST_Chemistry_WebBook]
synonym: "acide glutamique" RELATED INN [ChEBI]
synonym: "acido glutamico" RELATED INN [ChEBI]
synonym: "acidum glutamicum" RELATED INN [ChEBI]
synonym: "E" RELATED [ChEBI]
synonym: "Glu" RELATED [ChEBI]
synonym: "Glutamate" RELATED [KEGG_COMPOUND]
synonym: "GLUTAMIC ACID" RELATED [PDBeChem]
synonym: "glutamic acid" RELATED INN [ChEBI]
synonym: "L-Glu" RELATED [ChEBI]
synonym: "L-Glutamic acid" EXACT [KEGG_COMPOUND]
synonym: "L-glutamic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "L-Glutaminic acid" RELATED [KEGG_COMPOUND]
synonym: "L-Glutaminsaeure" RELATED [ChEBI]
xref: Beilstein:1723801 {source="Beilstein"}
xref: BPDB:2297
xref: CAS:56-86-0 {source="NIST Chemistry WebBook"}
xref: CAS:56-86-0 {source="ChemIDplus"}
xref: CAS:56-86-0 {source="KEGG COMPOUND"}
xref: Drug_Central:1310 {source="DrugCentral"}
xref: DrugBank:DB00142
xref: Gmelin:3502 {source="Gmelin"}
xref: HMDB:HMDB0000148
xref: KEGG:C00025
xref: KEGG:D00007
xref: KNApSAcK:C00001358
xref: LINCS:LSM-36375
xref: MetaCyc:GLT
xref: PDBeChem:GLU_LFOH
xref: PMID:15739367 {source="Europe PMC"}
xref: PMID:15930465 {source="Europe PMC"}
xref: PMID:16719819 {source="Europe PMC"}
xref: PMID:16892196 {source="Europe PMC"}
xref: PMID:19581495 {source="Europe PMC"}
xref: PMID:22219301 {source="Europe PMC"}
xref: PMID:22735334 {source="Europe PMC"}
xref: Reaxys:1723801 {source="Reaxys"}
xref: Wikipedia:L-Glutamic_Acid
is_a: CHEBI:18237 ! glutamic acid
is_a: CHEBI:24318 ! glutamine family amino acid
relationship: is_conjugate_acid_of CHEBI:29985 ! L-glutamate(1-)
relationship: is_enantiomer_of CHEBI:15966 ! D-glutamic acid
relationship: RO:0000087 CHEBI:173085 ! has role ferroptosis inducer
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-VKHMYHEASA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "147.12930" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "147.05316" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](CCC(O)=O)C(O)=O" xsd:string

[Term]
id: CHEBI:16042
name: halide anion
namespace: chebi_ontology
alt_id: CHEBI:14384
alt_id: CHEBI:5605
def: "A monoatomic monoanion resulting from the addition of an electron to any halogen atom." []
subset: 3_STAR
synonym: "a halide anion" RELATED [UniProt]
synonym: "Halide" RELATED [KEGG_COMPOUND]
synonym: "halide anions" RELATED [ChEBI]
synonym: "halide ions" EXACT IUPAC_NAME [IUPAC]
synonym: "halide(1-)" RELATED [ChEBI]
synonym: "halides" RELATED [ChEBI]
synonym: "halogen anion" RELATED [ChEBI]
synonym: "HX" RELATED [KEGG_COMPOUND]
xref: KEGG:C00462
is_a: CHEBI:33429 ! monoatomic monoanion
is_a: CHEBI:79389 ! monovalent inorganic anion
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "X" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*-]" xsd:string

[Term]
id: CHEBI:16134
name: ammonia
namespace: chebi_ontology
alt_id: CHEBI:13405
alt_id: CHEBI:13406
alt_id: CHEBI:13407
alt_id: CHEBI:13771
alt_id: CHEBI:22533
alt_id: CHEBI:44269
alt_id: CHEBI:44284
alt_id: CHEBI:44404
alt_id: CHEBI:7434
def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." []
subset: 3_STAR
synonym: "[NH3]" RELATED [MolBase]
synonym: "AMMONIA" EXACT [PDBeChem]
synonym: "Ammonia" EXACT [KEGG_COMPOUND]
synonym: "ammonia" EXACT IUPAC_NAME [IUPAC]
synonym: "ammoniac" RELATED [ChEBI]
synonym: "Ammoniak" RELATED [ChemIDplus]
synonym: "amoniaco" RELATED [ChEBI]
synonym: "azane" EXACT IUPAC_NAME [IUPAC]
synonym: "NH3" RELATED [KEGG_COMPOUND]
synonym: "NH3" RELATED [UniProt]
synonym: "NH3" RELATED [IUPAC]
synonym: "R-717" RELATED [ChEBI]
synonym: "spirit of hartshorn" RELATED [ChemIDplus]
xref: Beilstein:3587154 {source="Beilstein"}
xref: CAS:7664-41-7 {source="ChemIDplus"}
xref: CAS:7664-41-7 {source="NIST Chemistry WebBook"}
xref: CAS:7664-41-7 {source="KEGG COMPOUND"}
xref: Drug_Central:4625 {source="DrugCentral"}
xref: Gmelin:79 {source="Gmelin"}
xref: HMDB:HMDB0000051
xref: KEGG:C00014
xref: KEGG:D02916
xref: KNApSAcK:C00007267
xref: MetaCyc:AMMONIA
xref: MolBase:930
xref: PDBeChem:NH3
xref: PMID:110589 {source="Europe PMC"}
xref: PMID:11139349 {source="Europe PMC"}
xref: PMID:11540049 {source="Europe PMC"}
xref: PMID:11746427 {source="Europe PMC"}
xref: PMID:11783653 {source="Europe PMC"}
xref: PMID:13753780 {source="Europe PMC"}
xref: PMID:14663195 {source="Europe PMC"}
xref: PMID:15092448 {source="Europe PMC"}
xref: PMID:15094021 {source="Europe PMC"}
xref: PMID:15554424 {source="Europe PMC"}
xref: PMID:15969015 {source="Europe PMC"}
xref: PMID:16008360 {source="Europe PMC"}
xref: PMID:16050680 {source="Europe PMC"}
xref: PMID:16348008 {source="Europe PMC"}
xref: PMID:16349403 {source="Europe PMC"}
xref: PMID:16614889 {source="Europe PMC"}
xref: PMID:16664306 {source="Europe PMC"}
xref: PMID:16842901 {source="Europe PMC"}
xref: PMID:17025297 {source="Europe PMC"}
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:17569513 {source="Europe PMC"}
xref: PMID:17737668 {source="Europe PMC"}
xref: PMID:18670398 {source="Europe PMC"}
xref: PMID:22002069 {source="Europe PMC"}
xref: PMID:22081570 {source="Europe PMC"}
xref: PMID:22088435 {source="Europe PMC"}
xref: PMID:22100291 {source="Europe PMC"}
xref: PMID:22130175 {source="Europe PMC"}
xref: PMID:22150211 {source="Europe PMC"}
xref: PMID:22240068 {source="Europe PMC"}
xref: PMID:22290316 {source="Europe PMC"}
xref: PMID:22342082 {source="Europe PMC"}
xref: PMID:22385337 {source="Europe PMC"}
xref: PMID:22443779 {source="Europe PMC"}
xref: PMID:22560242 {source="Europe PMC"}
xref: Reaxys:3587154 {source="Reaxys"}
xref: Wikipedia:Ammonia
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:35107 ! azane
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: is_conjugate_acid_of CHEBI:29337 ! azanide
relationship: is_conjugate_base_of CHEBI:28938 ! ammonium
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H3N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3N/h1H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "17.03056" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.02655" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]N([H])[H]" xsd:string

[Term]
id: CHEBI:16189
name: sulfate
namespace: chebi_ontology
alt_id: CHEBI:15135
alt_id: CHEBI:45687
alt_id: CHEBI:9335
def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." []
subset: 3_STAR
synonym: "[SO4](2-)" RELATED [IUPAC]
synonym: "SO4(2-)" RELATED [IUPAC]
synonym: "Sulfate" EXACT [KEGG_COMPOUND]
synonym: "sulfate" EXACT [UniProt]
synonym: "sulfate" EXACT IUPAC_NAME [IUPAC]
synonym: "Sulfate anion(2-)" RELATED [HMDB]
synonym: "Sulfate dianion" RELATED [HMDB]
synonym: "SULFATE ION" RELATED [PDBeChem]
synonym: "Sulfate(2-)" RELATED [HMDB]
synonym: "Sulfuric acid ion(2-)" RELATED [HMDB]
synonym: "sulphate" RELATED [ChEBI]
synonym: "sulphate ion" RELATED [ChEBI]
synonym: "tetraoxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3648446 {source="Beilstein"}
xref: CAS:14808-79-8 {source="ChemIDplus"}
xref: CAS:14808-79-8 {source="NIST Chemistry WebBook"}
xref: Gmelin:2120 {source="Gmelin"}
xref: HMDB:HMDB0001448
xref: KEGG:C00059
xref: KEGG:D05963
xref: MetaCyc:SULFATE
xref: PDBeChem:SO4
xref: PMID:11200094 {source="Europe PMC"}
xref: PMID:11452993 {source="Europe PMC"}
xref: PMID:11581495 {source="Europe PMC"}
xref: PMID:11798107 {source="Europe PMC"}
xref: PMID:12166931 {source="Europe PMC"}
xref: PMID:12668033 {source="Europe PMC"}
xref: PMID:14597181 {source="Europe PMC"}
xref: PMID:15093386 {source="Europe PMC"}
xref: PMID:15984785 {source="Europe PMC"}
xref: PMID:16186560 {source="Europe PMC"}
xref: PMID:16345535 {source="Europe PMC"}
xref: PMID:16347366 {source="Europe PMC"}
xref: PMID:16348007 {source="Europe PMC"}
xref: PMID:16483812 {source="Europe PMC"}
xref: PMID:16534979 {source="Europe PMC"}
xref: PMID:16656509 {source="Europe PMC"}
xref: PMID:16742508 {source="Europe PMC"}
xref: PMID:16742518 {source="Europe PMC"}
xref: PMID:17120760 {source="Europe PMC"}
xref: PMID:17420092 {source="Europe PMC"}
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:17709180 {source="Europe PMC"}
xref: PMID:18398178 {source="Europe PMC"}
xref: PMID:18815700 {source="Europe PMC"}
xref: PMID:18846414 {source="Europe PMC"}
xref: PMID:19047345 {source="Europe PMC"}
xref: PMID:19244483 {source="Europe PMC"}
xref: PMID:19544990 {source="Europe PMC"}
xref: PMID:19628332 {source="Europe PMC"}
xref: PMID:19812358 {source="Europe PMC"}
xref: PMID:30398859 {source="Europe PMC"}
xref: Reaxys:3648446 {source="Reaxys"}
xref: Wikipedia:Sulfate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33482 ! sulfur oxoanion
is_a: CHEBI:48154 ! sulfur oxide
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06360" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95283" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:16199
name: urea
namespace: chebi_ontology
alt_id: CHEBI:15292
alt_id: CHEBI:27218
alt_id: CHEBI:46379
alt_id: CHEBI:9888
def: "A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O)." []
subset: 3_STAR
synonym: "1728" RELATED [PPDB]
synonym: "Carbamide" RELATED [KEGG_COMPOUND]
synonym: "carbamide" RELATED INN [ChEBI]
synonym: "carbonyldiamide" RELATED [NIST_Chemistry_WebBook]
synonym: "E927b" RELATED [ChEBI]
synonym: "H2NC(O)NH2" RELATED [ChEBI]
synonym: "Harnstoff" RELATED [NIST_Chemistry_WebBook]
synonym: "Karbamid" RELATED [ChEBI]
synonym: "ur" RELATED [IUPAC]
synonym: "UREA" EXACT [PDBeChem]
synonym: "Urea" EXACT [KEGG_COMPOUND]
synonym: "urea" EXACT [UniProt]
synonym: "urea" EXACT IUPAC_NAME [IUPAC]
synonym: "uree" RELATED [ChEBI]
xref: Beilstein:635724 {source="Beilstein"}
xref: CAS:57-13-6 {source="ChemIDplus"}
xref: CAS:57-13-6 {source="NIST Chemistry WebBook"}
xref: CAS:57-13-6 {source="KEGG COMPOUND"}
xref: Drug_Central:4264 {source="DrugCentral"}
xref: DrugBank:DB03904
xref: ECMDB:ECMDB04172
xref: Gmelin:1378 {source="Gmelin"}
xref: HMDB:HMDB0000294
xref: KEGG:C00086
xref: KEGG:D00023
xref: KNApSAcK:C00007314
xref: MetaCyc:UREA
xref: PDBeChem:URE
xref: PMID:18037357 {source="Europe PMC"}
xref: PMID:22770225 {source="Europe PMC"}
xref: PPDB:1728
xref: Reaxys:635724 {source="Reaxys"}
xref: UM-BBD_compID:c0165 {source="UM-BBD"}
xref: Wikipedia:Urea
xref: YMDB:YMDB00003
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:64708 ! one-carbon compound
relationship: has_functional_parent CHEBI:28976 ! carbonic acid
relationship: is_tautomer_of CHEBI:48376 ! carbamimidic acid
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer
relationship: RO:0000087 CHEBI:64577 ! has role flour treatment agent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4N2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XSQUKJJJFZCRTK-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.05534" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.03236" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(N)=O" xsd:string

[Term]
id: CHEBI:16235
name: guanine
namespace: chebi_ontology
alt_id: CHEBI:14371
alt_id: CHEBI:14372
alt_id: CHEBI:24443
alt_id: CHEBI:42948
alt_id: CHEBI:5563
def: "A 2-aminopurine carrying a 6-oxo substituent." []
subset: 3_STAR
synonym: "2-amino-1,9-dihydro-6H-purin-6-one" EXACT IUPAC_NAME [IUPAC]
synonym: "2-Amino-6-hydroxypurine" RELATED [KEGG_COMPOUND]
synonym: "2-amino-6-oxopurine" RELATED [ChEBI]
synonym: "G" RELATED [ChEBI]
synonym: "Gua" RELATED [CBN]
synonym: "GUANINE" EXACT [PDBeChem]
synonym: "Guanine" EXACT [KEGG_COMPOUND]
synonym: "guanine" EXACT [UniProt]
xref: Beilstein:147911 {source="Beilstein"}
xref: CAS:73-40-5 {source="NIST Chemistry WebBook"}
xref: CAS:73-40-5 {source="ChemIDplus"}
xref: CAS:73-40-5 {source="KEGG COMPOUND"}
xref: DrugBank:DB02377
xref: Gmelin:431879 {source="Gmelin"}
xref: HMDB:HMDB0000132
xref: KEGG:C00242
xref: KNApSAcK:C00001501
xref: MetaCyc:GUANINE
xref: PDBeChem:GUN
xref: PMID:22770225 {source="Europe PMC"}
xref: PMID:8070089 {source="Europe PMC"}
xref: Reaxys:147911 {source="Reaxys"}
xref: Wikipedia:Guanine
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:20702 ! 2-aminopurines
is_a: CHEBI:25810 ! oxopurine
is_a: CHEBI:26386 ! purine nucleobase
relationship: has_parent_hydride CHEBI:35589 ! 9H-purine
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H5N5O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UYTPUPDQBNUYGX-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "151.126" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "151.04941" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12=C(N=C(NC1=O)N)NC=N2" xsd:string

[Term]
id: CHEBI:16385
name: organic sulfide
namespace: chebi_ontology
alt_id: CHEBI:13694
alt_id: CHEBI:26960
alt_id: CHEBI:9340
def: "Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers." []
subset: 3_STAR
synonym: "organic sulfides" RELATED [ChEBI]
synonym: "RSR" RELATED [IUPAC]
synonym: "Sulfide" RELATED [KEGG_COMPOUND]
synonym: "sulfides" EXACT IUPAC_NAME [IUPAC]
synonym: "Thioether" RELATED [KEGG_COMPOUND]
synonym: "thioethers" RELATED [IUPAC]
xref: KEGG:C00297
is_a: CHEBI:26822 ! sulfide
is_a: CHEBI:33261 ! organosulfur compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "SR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "32.066" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97207" xsd:string

[Term]
id: CHEBI:16482
name: naphthalene
namespace: chebi_ontology
alt_id: CHEBI:14638
alt_id: CHEBI:25469
alt_id: CHEBI:44619
alt_id: CHEBI:7472
def: "An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia." []
subset: 3_STAR
synonym: "naftaleno" RELATED [ChEBI]
synonym: "naftalina" RELATED [ChEBI]
synonym: "naphtalene" RELATED [ChEBI]
synonym: "naphtaline" RELATED [ChEBI]
synonym: "Naphthalen" RELATED [ChEBI]
synonym: "NAPHTHALENE" EXACT [PDBeChem]
synonym: "Naphthalene" EXACT [KEGG_COMPOUND]
synonym: "naphthalene" EXACT [UniProt]
synonym: "naphthalene" EXACT IUPAC_NAME [IUPAC]
synonym: "Naphthalin" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1421310 {source="Beilstein"}
xref: CAS:91-20-3 {source="ChemIDplus"}
xref: CAS:91-20-3 {source="KEGG COMPOUND"}
xref: CAS:91-20-3 {source="NIST Chemistry WebBook"}
xref: Gmelin:3347 {source="Gmelin"}
xref: HMDB:HMDB0029751
xref: KEGG:C00829
xref: KNApSAcK:C00001259
xref: MetaCyc:NAPHTHALENE
xref: PDBeChem:NPY
xref: PMID:10814889 {source="Europe PMC"}
xref: PMID:11202734 {source="Europe PMC"}
xref: PMID:16220979 {source="Europe PMC"}
xref: PMID:16699520 {source="Europe PMC"}
xref: PMID:17850896 {source="Europe PMC"}
xref: PMID:26875834 {source="Europe PMC"}
xref: PMID:26895256 {source="Europe PMC"}
xref: PMID:27439360 {source="Europe PMC"}
xref: PPDB:1312
xref: Reaxys:1421310 {source="Reaxys"}
xref: UM-BBD_compID:c0333 {source="UM-BBD"}
xref: Wikipedia:Naphthalene
is_a: CHEBI:25477 ! naphthalenes
is_a: CHEBI:35426 ! ortho-fused bicyclic arene
relationship: RO:0000087 CHEBI:27311 ! has role volatile oil component
relationship: RO:0000087 CHEBI:68494 ! has role apoptosis inhibitor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H8" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UFWIBTONFRDIAS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "128.17052" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "128.06260" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2ccccc2c1" xsd:string

[Term]
id: CHEBI:16509
name: 1,4-benzoquinone
namespace: chebi_ontology
alt_id: CHEBI:12837
alt_id: CHEBI:15009
alt_id: CHEBI:18927
alt_id: CHEBI:49820
alt_id: CHEBI:8730
def: "The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene." []
subset: 3_STAR
synonym: "1,4-Benzochinon" RELATED [ChEBI]
synonym: "1,4-Benzoquinone" EXACT [KEGG_COMPOUND]
synonym: "1,4-benzoquinone" EXACT [UniProt]
synonym: "1,4-benzoquinone" EXACT [NIST_Chemistry_WebBook]
synonym: "2,5-Cyclohexadiene-1,4-dione" RELATED [KEGG_COMPOUND]
synonym: "benzo-1,4-quinone" RELATED [NIST_Chemistry_WebBook]
synonym: "benzoquinone" RELATED [ChemIDplus]
synonym: "cyclohexa-2,5-diene-1,4-dione" EXACT IUPAC_NAME [IUPAC]
synonym: "p-Benzoquinone" RELATED [KEGG_COMPOUND]
synonym: "p-Chinon" RELATED [NIST_Chemistry_WebBook]
synonym: "p-quinone" RELATED [HMDB]
synonym: "para-benzoquinone" RELATED [HMDB]
synonym: "Quinone" RELATED [KEGG_COMPOUND]
xref: Beilstein:773967 {source="Beilstein"}
xref: CAS:106-51-4 {source="NIST Chemistry WebBook"}
xref: CAS:106-51-4 {source="ChemIDplus"}
xref: CAS:106-51-4 {source="KEGG COMPOUND"}
xref: Gmelin:2741 {source="Gmelin"}
xref: HMDB:HMDB0003364
xref: KEGG:C00472
xref: KEGG:C15602
xref: MetaCyc:P-BENZOQUINONE
xref: PDBeChem:PLQ
xref: PMID:10462055 {source="Europe PMC"}
xref: PMID:11304127 {source="Europe PMC"}
xref: PMID:1395635 {source="Europe PMC"}
xref: PMID:15182198 {source="Europe PMC"}
xref: PMID:15618234 {source="Europe PMC"}
xref: PMID:15920754 {source="Europe PMC"}
xref: PMID:16484134 {source="Europe PMC"}
xref: PMID:24023812 {source="Europe PMC"}
xref: PMID:25057895 {source="Europe PMC"}
xref: PMID:9118901 {source="Europe PMC"}
xref: Reaxys:773967 {source="Reaxys"}
xref: UM-BBD_compID:c0261 {source="UM-BBD"}
xref: Wikipedia:1\,4-Benzoquinone
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:132124 ! 1,4-benzoquinones
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H4O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H4O2/c7-5-1-2-6(8)4-3-5/h1-4H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AZQWKYJCGOJGHM-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "108.09480" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "108.02113" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1C=CC(=O)C=C1" xsd:string

[Term]
id: CHEBI:16646
name: carbohydrate
namespace: chebi_ontology
alt_id: CHEBI:15131
alt_id: CHEBI:23008
alt_id: CHEBI:9318
def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
subset: 3_STAR
synonym: "a carbohydrate" RELATED [UniProt]
synonym: "carbohidrato" RELATED [IUPAC]
synonym: "carbohidratos" RELATED [IUPAC]
synonym: "carbohydrate" EXACT IUPAC_NAME [IUPAC]
synonym: "carbohydrates" EXACT IUPAC_NAME [IUPAC]
synonym: "glucide" RELATED [ChEBI]
synonym: "glucides" RELATED [ChEBI]
synonym: "glucido" RELATED [ChEBI]
synonym: "glucidos" RELATED [ChEBI]
synonym: "hydrates de carbone" RELATED [ChEBI]
synonym: "Kohlenhydrat" RELATED [ChEBI]
synonym: "Kohlenhydrate" RELATED [ChEBI]
synonym: "saccharide" RELATED [IUPAC]
synonym: "saccharides" RELATED [IUPAC]
synonym: "saccharidum" RELATED [ChEBI]
xref: Wikipedia:Carbohydrate
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:16670
name: peptide
namespace: chebi_ontology
alt_id: CHEBI:14753
alt_id: CHEBI:25906
alt_id: CHEBI:7990
def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." []
subset: 3_STAR
synonym: "Peptid" RELATED [ChEBI]
synonym: "Peptide" EXACT [KEGG_COMPOUND]
synonym: "peptides" EXACT IUPAC_NAME [IUPAC]
synonym: "peptido" RELATED [ChEBI]
synonym: "peptidos" RELATED [ChEBI]
xref: KEGG:C00012
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:50047 ! organic amino compound
relationship: BFO:0000051 CHEBI:33708 ! has part amino-acid residue
relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "(C2H2NOR)nC2H3NOR" xsd:string

[Term]
id: CHEBI:16716
name: benzene
namespace: chebi_ontology
alt_id: CHEBI:13876
alt_id: CHEBI:22703
alt_id: CHEBI:3025
alt_id: CHEBI:41187
def: "A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system." []
subset: 3_STAR
synonym: "[6]annulene" RELATED [NIST_Chemistry_WebBook]
synonym: "Benzen" RELATED [IUPAC]
synonym: "BENZENE" EXACT [PDBeChem]
synonym: "Benzene" EXACT [KEGG_COMPOUND]
synonym: "benzene" EXACT IUPAC_NAME [IUPAC]
synonym: "benzene" EXACT [UniProt]
synonym: "benzene" EXACT [ChEBI]
synonym: "Benzine" RELATED [UM-BBD]
synonym: "Benzol" RELATED [ChemIDplus]
synonym: "benzole" RELATED [NIST_Chemistry_WebBook]
synonym: "Bicarburet of hydrogen" RELATED [ChemIDplus]
synonym: "Coal naphtha" RELATED [ChemIDplus]
synonym: "cyclohexatriene" RELATED [UM-BBD]
synonym: "Mineral naphtha" RELATED [ChemIDplus]
synonym: "Phene" RELATED [ChemIDplus]
synonym: "phenyl hydride" RELATED [UM-BBD]
synonym: "Pyrobenzol" RELATED [ChemIDplus]
synonym: "Pyrobenzole" RELATED [ChemIDplus]
xref: Beilstein:969212 {source="Beilstein"}
xref: CAS:71-43-2 {source="ChemIDplus"}
xref: CAS:71-43-2 {source="NIST Chemistry WebBook"}
xref: CAS:71-43-2 {source="KEGG COMPOUND"}
xref: Gmelin:1671 {source="Gmelin"}
xref: HMDB:HMDB0001505
xref: KEGG:C01407
xref: PDBeChem:BNZ
xref: PMID:11684179 {source="Europe PMC"}
xref: PMID:11993966 {source="Europe PMC"}
xref: PMID:12857942 {source="Europe PMC"}
xref: PMID:14677922 {source="Europe PMC"}
xref: PMID:15468289 {source="Europe PMC"}
xref: PMID:15935818 {source="Europe PMC"}
xref: PMID:16161967 {source="Europe PMC"}
xref: PMID:17373369 {source="Europe PMC"}
xref: PMID:18072742 {source="Europe PMC"}
xref: PMID:18407866 {source="Europe PMC"}
xref: PMID:18409691 {source="Europe PMC"}
xref: PMID:18836923 {source="Europe PMC"}
xref: PMID:19228219 {source="Europe PMC"}
xref: PMID:21325737 {source="Europe PMC"}
xref: PMID:23088855 {source="Europe PMC"}
xref: PMID:23222815 {source="Europe PMC"}
xref: PMID:23534829 {source="Europe PMC"}
xref: PMID:6353911 {source="Europe PMC"}
xref: PMID:8124204 {source="Europe PMC"}
xref: Reaxys:969212 {source="Reaxys"}
xref: UM-BBD_compID:c0142 {source="UM-BBD"}
xref: Wikipedia:Benzene
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33842 ! aromatic annulene
relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UHOVQNZJYSORNB-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "78.11184" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "78.04695" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccccc1" xsd:string

[Term]
id: CHEBI:16733
name: D-alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:12909
alt_id: CHEBI:13625
alt_id: CHEBI:20906
alt_id: CHEBI:4097
subset: 3_STAR
synonym: "D-alpha-amino acid" EXACT [ChEBI]
synonym: "D-alpha-amino acids" EXACT IUPAC_NAME [IUPAC]
synonym: "D-alpha-amino acids" RELATED [ChEBI]
synonym: "D-Amino acid" RELATED [KEGG_COMPOUND]
xref: KEGG:C00405
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
relationship: is_conjugate_acid_of CHEBI:60895 ! D-alpha-amino acid anion
relationship: is_tautomer_of CHEBI:59871 ! D-alpha-amino acid zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H]([*])C(O)=O" xsd:string

[Term]
id: CHEBI:167559
name: glycan
namespace: chebi_ontology
def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." []
subset: 3_STAR
synonym: "glycans" RELATED [ChEBI]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:16842
name: formaldehyde
namespace: chebi_ontology
alt_id: CHEBI:14274
alt_id: CHEBI:24077
alt_id: CHEBI:337763
alt_id: CHEBI:5142
def: "An aldehyde resulting from the formal oxidation of methanol." []
subset: 3_STAR
synonym: "Formaldehyd" RELATED [NIST_Chemistry_WebBook]
synonym: "FORMALDEHYDE" EXACT [PDBeChem]
synonym: "Formaldehyde" EXACT [KEGG_COMPOUND]
synonym: "formaldehyde" EXACT [UniProt]
synonym: "formaldehyde" EXACT IUPAC_NAME [IUPAC]
synonym: "FORMALIN" RELATED [ChEMBL]
synonym: "Formalin" RELATED [KEGG_COMPOUND]
synonym: "Methanal" RELATED [KEGG_COMPOUND]
synonym: "Methylene oxide" RELATED [KEGG_COMPOUND]
synonym: "Oxomethane" RELATED [KEGG_COMPOUND]
synonym: "Oxomethylene" RELATED [KEGG_COMPOUND]
xref: Beilstein:1209228 {source="Beilstein"}
xref: CAS:50-00-0 {source="NIST Chemistry WebBook"}
xref: CAS:50-00-0 {source="ChemIDplus"}
xref: CAS:50-00-0 {source="KEGG COMPOUND"}
xref: Drug_Central:3244 {source="DrugCentral"}
xref: DrugBank:DB03843
xref: Gmelin:445 {source="Gmelin"}
xref: HMDB:HMDB0001426
xref: KEGG:C00067
xref: KEGG:D00017
xref: MetaCyc:FORMALDEHYDE
xref: PDBeChem:FOR
xref: PMID:110589 {source="Europe PMC"}
xref: PMID:12686735 {source="Europe PMC"}
xref: PMID:15091529 {source="Europe PMC"}
xref: PMID:16423181 {source="Europe PMC"}
xref: PMID:17618393 {source="Europe PMC"}
xref: PMID:18837732 {source="Europe PMC"}
xref: PMID:25042713 {source="Europe PMC"}
xref: PMID:7381846 {source="ChEMBL"}
xref: PMID:7548723 {source="Europe PMC"}
xref: PMID:7689168 {source="Europe PMC"}
xref: PMID:7896413 {source="Europe PMC"}
xref: PMID:9686972 {source="Europe PMC"}
xref: PPDB:359
xref: Reaxys:1209228 {source="Reaxys"}
xref: UM-BBD_compID:c0122 {source="UM-BBD"}
xref: Wikipedia:Formaldehyde
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:17478 ! aldehyde
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0000087 CHEBI:48219 ! has role disinfectant
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O/c1-2/h1H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSFSSNUMVMOOMR-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "30.02598" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.01056" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([H])=O" xsd:string

[Term]
id: CHEBI:16991
name: deoxyribonucleic acid
namespace: chebi_ontology
alt_id: CHEBI:13302
alt_id: CHEBI:21123
alt_id: CHEBI:33698
alt_id: CHEBI:4291
def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." []
subset: 3_STAR
synonym: "(Deoxyribonucleotide)m" RELATED [KEGG_COMPOUND]
synonym: "(Deoxyribonucleotide)n" RELATED [KEGG_COMPOUND]
synonym: "(Deoxyribonucleotide)n+m" RELATED [KEGG_COMPOUND]
synonym: "Deoxyribonucleic acid" EXACT [KEGG_COMPOUND]
synonym: "deoxyribonucleic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "deoxyribonucleic acids" RELATED [ChEBI]
synonym: "Desoxyribonukleinsaeure" RELATED [ChEBI]
synonym: "desoxyribose nucleic acid" RELATED [ChemIDplus]
synonym: "DNA" RELATED [UniProt]
synonym: "DNA" RELATED [KEGG_COMPOUND]
synonym: "DNA" RELATED [IUPAC]
synonym: "DNAn" RELATED [KEGG_COMPOUND]
synonym: "DNAn+1" RELATED [KEGG_COMPOUND]
synonym: "DNS" RELATED [ChEBI]
synonym: "thymus nucleic acid" RELATED [ChEBI]
xref: CAS:9007-49-2 {source="ChemIDplus"}
xref: CAS:9007-49-2 {source="KEGG COMPOUND"}
xref: KEGG:C00039
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33696 ! nucleic acid
relationship: BFO:0000051 CHEBI:33793 ! has part canonical deoxyribonucleoside residue
relationship: BFO:0000051 CHEBI:50298 ! has part canonical deoxyribonucleotide residue
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:16998
name: D-phenylalanine
namespace: chebi_ontology
alt_id: CHEBI:13007
alt_id: CHEBI:21067
alt_id: CHEBI:42207
alt_id: CHEBI:4224
def: "The D-enantiomer of phenylalanine." []
subset: 3_STAR
synonym: "(2R)-2-amino-3-phenylpropanoic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "D-alpha-Amino-beta-phenylpropionic acid" RELATED [KEGG_COMPOUND]
synonym: "D-Phe" RELATED [ChEBI]
synonym: "D-PHENYLALANINE" EXACT [PDBeChem]
synonym: "D-Phenylalanine" EXACT [KEGG_COMPOUND]
synonym: "D-phenylalanine" EXACT IUPAC_NAME [IUPAC]
synonym: "DPN" RELATED [PDBeChem]
synonym: "phenylalanine D-form" RELATED [ChemIDplus]
xref: Beilstein:2804068 {source="Beilstein"}
xref: CAS:673-06-3 {source="KEGG COMPOUND"}
xref: CAS:673-06-3 {source="ChemIDplus"}
xref: DrugBank:DB02556
xref: ECMDB:ECMDB20144
xref: Gmelin:83219 {source="Gmelin"}
xref: KEGG:C02265
xref: MetaCyc:CPD-216
xref: PDBeChem:DPN
xref: PMID:22382026 {source="Europe PMC"}
xref: PMID:22397264 {source="Europe PMC"}
xref: PMID:24464217 {source="Europe PMC"}
xref: PMID:7114516 {source="Europe PMC"}
xref: Reaxys:2804068 {source="Reaxys"}
xref: YMDB:YMDB00995
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:28044 ! phenylalanine
relationship: is_conjugate_acid_of CHEBI:32494 ! D-phenylalaninate
relationship: is_conjugate_base_of CHEBI:32495 ! D-phenylalaninium
relationship: is_enantiomer_of CHEBI:17295 ! L-phenylalanine
relationship: is_tautomer_of CHEBI:57981 ! D-phenylalanine zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18918" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H](Cc1ccccc1)C(O)=O" xsd:string

[Term]
id: CHEBI:17051
name: fluoride
namespace: chebi_ontology
alt_id: CHEBI:14271
alt_id: CHEBI:49593
alt_id: CHEBI:5113
subset: 3_STAR
synonym: "F(-)" RELATED [IUPAC]
synonym: "F-" RELATED [KEGG_COMPOUND]
synonym: "Fluoride" EXACT [KEGG_COMPOUND]
synonym: "fluoride" EXACT [UniProt]
synonym: "fluoride" EXACT IUPAC_NAME [IUPAC]
synonym: "FLUORIDE ION" RELATED [PDBeChem]
synonym: "Fluoride ion" RELATED [KEGG_COMPOUND]
synonym: "fluoride(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "Fluorine anion" RELATED [NIST_Chemistry_WebBook]
xref: CAS:16984-48-8 {source="NIST Chemistry WebBook"}
xref: CAS:16984-48-8 {source="ChemIDplus"}
xref: Gmelin:14905 {source="Gmelin"}
xref: KEGG:C00742
xref: PDBeChem:F
is_a: CHEBI:16042 ! halide anion
is_a: CHEBI:36895 ! monoatomic fluorine
relationship: is_conjugate_base_of CHEBI:29228 ! hydrogen fluoride
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "F" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/FH/h1H/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KRHYYFGTRYWZRS-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "18.99840" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99895" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[F-]" xsd:string

[Term]
id: CHEBI:17087
name: ketone
namespace: chebi_ontology
alt_id: CHEBI:13427
alt_id: CHEBI:13646
alt_id: CHEBI:24974
alt_id: CHEBI:6127
alt_id: CHEBI:8742
def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." []
subset: 3_STAR
synonym: "a ketone" RELATED [UniProt]
synonym: "cetone" RELATED [ChEBI]
synonym: "Keton" RELATED [ChEBI]
synonym: "Ketone" EXACT [KEGG_COMPOUND]
synonym: "ketones" EXACT IUPAC_NAME [IUPAC]
synonym: "ketones" RELATED [ChEBI]
synonym: "R-CO-R'" RELATED [KEGG_COMPOUND]
xref: KEGG:C01450
xref: Wikipedia:Ketone
is_a: CHEBI:36586 ! carbonyl compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "COR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "28.010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C([*])=O" xsd:string

[Term]
id: CHEBI:17102
name: phosphoramide
namespace: chebi_ontology
alt_id: CHEBI:14827
alt_id: CHEBI:26076
alt_id: CHEBI:8162
def: "A compound in which one or more of the OH groups of phosphoric acid have been replaced with an amino or substituted amino group. The term is commonly confined to the phosphoric triamides, P(=O)(NR2)3, since replacement of one or two OH groups produces phosphoramidic acids: P(=O)(OH)(NR2)2 , P(=O)(OH)2(NR2)." []
subset: 3_STAR
synonym: "phosphamide" RELATED [ChEBI]
synonym: "phosphamides" RELATED [ChEBI]
synonym: "phosphoramides" RELATED [ChEBI]
is_a: CHEBI:33256 ! primary amide
relationship: has_functional_parent CHEBI:26078 ! phosphoric acid

[Term]
id: CHEBI:17137
name: hydrogensulfite
namespace: chebi_ontology
alt_id: CHEBI:13367
alt_id: CHEBI:5598
subset: 3_STAR
synonym: "[SO2(OH)](-)" RELATED [IUPAC]
synonym: "Bisulfite" RELATED [KEGG_COMPOUND]
synonym: "bisulfite" RELATED [ChemIDplus]
synonym: "bisulphite" RELATED [ChemIDplus]
synonym: "HSO3(-)" RELATED [IUPAC]
synonym: "HSO3-" RELATED [KEGG_COMPOUND]
synonym: "Hydrogen sulfite" RELATED [KEGG_COMPOUND]
synonym: "hydrogen sulfite(1-)" RELATED [ChemIDplus]
synonym: "hydrogen(trioxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogensulfite(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentrioxosulfate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentrioxosulfate(IV)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrosulfite anion" RELATED [ChemIDplus]
synonym: "hydroxidodioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "monohydrogentrioxosulfate" EXACT IUPAC_NAME [IUPAC]
xref: CAS:15181-46-1 {source="KEGG COMPOUND"}
xref: CAS:15181-46-1 {source="ChemIDplus"}
xref: Gmelin:1455 {source="Gmelin"}
xref: KEGG:C11481
xref: PDBeChem:SO3
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: is_conjugate_acid_of CHEBI:17359 ! sulfite
relationship: is_conjugate_base_of CHEBI:48854 ! sulfurous acid
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96519" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS([O-])=O" xsd:string

[Term]
id: CHEBI:172390
name: glycol ether
namespace: chebi_ontology
def: "A hydroxyether which contains both an ether and alcohol functional groups. It is one of the most versatile classes of organic solvents which are commonly used in paints, cleaners, adhesives, pharmaceuticals and cosmetics." []
subset: 3_STAR
synonym: "glycol ethers" RELATED [ChEBI]
xref: PMID:28650840 {source="Europe PMC"}
xref: PMID:29536623 {source="Europe PMC"}
xref: PMID:30471335 {source="Europe PMC"}
xref: PMID:31518935 {source="Europe PMC"}
xref: PMID:32172156 {source="Europe PMC"}
xref: Wikipedia:Glycol_ethers
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:46789 ! hydroxyether
relationship: has_functional_parent CHEBI:13643 ! glycol
relationship: RO:0000087 CHEBI:48356 ! has role protic solvent

[Term]
id: CHEBI:17258
name: 7H-purine
namespace: chebi_ontology
alt_id: CHEBI:14968
alt_id: CHEBI:8639
def: "The 7H-tautomer of purine." []
subset: 3_STAR
synonym: "7H-purine" EXACT IUPAC_NAME [IUPAC]
synonym: "Purine" RELATED [KEGG_COMPOUND]
synonym: "Purine base" RELATED [KEGG_COMPOUND]
xref: Beilstein:3200 {source="Beilstein"}
xref: Gmelin:601779 {source="Gmelin"}
xref: HMDB:HMDB0001366
xref: KEGG:C15587
xref: Reaxys:3200 {source="Reaxys"}
is_a: CHEBI:35584 ! purine
relationship: is_tautomer_of CHEBI:35586 ! 1H-purine
relationship: is_tautomer_of CHEBI:35588 ! 3H-purine
relationship: is_tautomer_of CHEBI:35589 ! 9H-purine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11222" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ncc2[nH]cnc2n1" xsd:string

[Term]
id: CHEBI:17295
name: L-phenylalanine
namespace: chebi_ontology
alt_id: CHEBI:13151
alt_id: CHEBI:21370
alt_id: CHEBI:44851
alt_id: CHEBI:44885
alt_id: CHEBI:45079
alt_id: CHEBI:6282
def: "The L-enantiomer of phenylalanine." []
subset: 3_STAR
synonym: "(2S)-2-amino-3-phenylpropanoic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "(S)-2-Amino-3-phenylpropionic acid" RELATED [HMDB]
synonym: "(S)-alpha-Amino-beta-phenylpropionic acid" RELATED [KEGG_COMPOUND]
synonym: "3-phenyl-L-alanine" RELATED [NIST_Chemistry_WebBook]
synonym: "beta-phenyl-L-alanine" RELATED [NIST_Chemistry_WebBook]
synonym: "F" RELATED [ChEBI]
synonym: "L-Phenylalanine" EXACT [KEGG_COMPOUND]
synonym: "L-phenylalanine" EXACT IUPAC_NAME [IUPAC]
synonym: "Phe" RELATED [ChEBI]
synonym: "PHENYLALANINE" RELATED [PDBeChem]
xref: Beilstein:1910408 {source="Beilstein"}
xref: CAS:63-91-2 {source="KEGG COMPOUND"}
xref: CAS:63-91-2 {source="NIST Chemistry WebBook"}
xref: CAS:63-91-2 {source="ChemIDplus"}
xref: Drug_Central:2144 {source="DrugCentral"}
xref: DrugBank:DB00120
xref: ECMDB:ECMDB00159
xref: Gmelin:50837 {source="Gmelin"}
xref: HMDB:HMDB0000159
xref: KEGG:C00079
xref: KEGG:D00021
xref: KNApSAcK:C00001386
xref: MetaCyc:PHE
xref: PDBeChem:PHE
xref: PMID:13945318 {source="Europe PMC"}
xref: PMID:16893175 {source="Europe PMC"}
xref: PMID:17784858 {source="Europe PMC"}
xref: PMID:21203787 {source="Europe PMC"}
xref: PMID:21956539 {source="Europe PMC"}
xref: PMID:22081386 {source="Europe PMC"}
xref: PMID:22112574 {source="Europe PMC"}
xref: PMID:22143120 {source="Europe PMC"}
xref: PMID:22209218 {source="Europe PMC"}
xref: PMID:22494897 {source="Europe PMC"}
xref: PMID:23836015 {source="Europe PMC"}
xref: PMID:24464217 {source="Europe PMC"}
xref: PMID:24733517 {source="Europe PMC"}
xref: PMID:24966042 {source="Europe PMC"}
xref: Reaxys:1910408 {source="Reaxys"}
xref: Wikipedia:Phenylalanine
xref: YMDB:YMDB00304
is_a: CHEBI:28044 ! phenylalanine
is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid
relationship: is_conjugate_acid_of CHEBI:32486 ! L-phenylalaninate
relationship: is_conjugate_base_of CHEBI:32487 ! L-phenylalaninium
relationship: is_enantiomer_of CHEBI:16998 ! D-phenylalanine
relationship: is_tautomer_of CHEBI:58095 ! L-phenylalanine zwitterion
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0000087 CHEBI:63332 ! has role EC 3.1.3.1 (alkaline phosphatase) inhibitor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18918" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](Cc1ccccc1)C(O)=O" xsd:string

[Term]
id: CHEBI:173085
name: ferroptosis inducer
namespace: chebi_ontology
def: "Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." []
subset: 3_STAR
synonym: "ferroptosis inducers" RELATED [ChEBI]
xref: PMID:31899616 {source="Europe PMC"}
xref: PMID:32015325 {source="SUBMITTER"}
xref: PMID:33167414 {source="Europe PMC"}
xref: PMID:34012798 {source="Europe PMC"}
xref: Wikipedia:Ferroptosis
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:17359
name: sulfite
namespace: chebi_ontology
alt_id: CHEBI:15139
alt_id: CHEBI:45548
def: "A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3)." []
subset: 3_STAR
synonym: "[SO3](2-)" RELATED [IUPAC]
synonym: "SO3" RELATED [ChEBI]
synonym: "SO3(2-)" RELATED [IUPAC]
synonym: "sulfite" EXACT IUPAC_NAME [IUPAC]
synonym: "sulfite" EXACT [UniProt]
synonym: "SULFITE ION" RELATED [PDBeChem]
synonym: "sulphite" RELATED [ChEBI]
synonym: "trioxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "trioxosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "trioxosulfate(IV)" EXACT IUPAC_NAME [IUPAC]
xref: CAS:14265-45-3 {source="ChemIDplus"}
xref: Gmelin:1449 {source="Gmelin"}
xref: PDBeChem:SO3
is_a: CHEBI:33482 ! sulfur oxoanion
is_a: CHEBI:48154 ! sulfur oxide
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: is_conjugate_base_of CHEBI:17137 ! hydrogensulfite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "80.06420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.95791" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S([O-])=O" xsd:string

[Term]
id: CHEBI:17418
name: valeric acid
namespace: chebi_ontology
alt_id: CHEBI:113448
alt_id: CHEBI:27263
alt_id: CHEBI:27264
alt_id: CHEBI:43606
alt_id: CHEBI:44803
alt_id: CHEBI:7980
def: "A straight-chain saturated fatty acid containing five carbon atoms." []
subset: 3_STAR
synonym: "1-butanecarboxylic acid" RELATED [NIST_Chemistry_WebBook]
synonym: "1-butanecarboxylic acid" RELATED [ChemIDplus]
synonym: "CH3-[CH2]3-COOH" RELATED [IUPAC]
synonym: "n-BuCOOH" RELATED [ChEBI]
synonym: "n-Pentanoate" RELATED [KEGG_COMPOUND]
synonym: "n-pentanoic acid" RELATED [ChemIDplus]
synonym: "n-Valeric acid" RELATED [KEGG_COMPOUND]
synonym: "n-valeric acid" RELATED [ChemIDplus]
synonym: "Pentanoate" RELATED [KEGG_COMPOUND]
synonym: "PENTANOIC ACID" RELATED [PDBeChem]
synonym: "Pentanoic acid" RELATED [KEGG_COMPOUND]
synonym: "pentanoic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "pentoic acid" RELATED [ChEBI]
synonym: "propylacetic acid" RELATED [ChemIDplus]
synonym: "Valerate" RELATED [KEGG_COMPOUND]
synonym: "Valerianic acid" RELATED [KEGG_COMPOUND]
synonym: "Valeriansaeure" RELATED [ChEBI]
synonym: "Valeric acid" EXACT [KEGG_COMPOUND]
synonym: "valeric acid, normal" RELATED [ChemIDplus]
xref: Beilstein:969454 {source="Beilstein"}
xref: CAS:109-52-4 {source="ChemIDplus"}
xref: CAS:109-52-4 {source="NIST Chemistry WebBook"}
xref: CAS:109-52-4 {source="KEGG COMPOUND"}
xref: DrugBank:DB02406
xref: Gmelin:26714 {source="Gmelin"}
xref: HMDB:HMDB0000892
xref: KEGG:C00803
xref: KNApSAcK:C00001208
xref: LIPID_MAPS_instance:LMFA01010005 {source="LIPID MAPS"}
xref: PDBeChem:LEA
xref: PMID:20507156 {source="Europe PMC"}
xref: PPDB:3130
xref: Reaxys:969454 {source="Reaxys"}
xref: Wikipedia:Valeric_acid
is_a: CHEBI:26666 ! short-chain fatty acid
is_a: CHEBI:39418 ! straight-chain saturated fatty acid
relationship: is_conjugate_acid_of CHEBI:31011 ! valerate
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NQPDZGIKBAWPEJ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "102.13170" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.06808" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCC(O)=O" xsd:string

[Term]
id: CHEBI:17478
name: aldehyde
namespace: chebi_ontology
alt_id: CHEBI:13432
alt_id: CHEBI:13753
alt_id: CHEBI:13805
alt_id: CHEBI:13806
alt_id: CHEBI:22291
alt_id: CHEBI:2554
alt_id: CHEBI:8750
def: "A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group." []
subset: 3_STAR
synonym: "aldehido" RELATED [ChEBI]
synonym: "aldehidos" RELATED [ChEBI]
synonym: "Aldehyd" RELATED [ChEBI]
synonym: "Aldehyde" EXACT [KEGG_COMPOUND]
synonym: "aldehyde" EXACT [ChEBI]
synonym: "aldehyde" EXACT IUPAC_NAME [IUPAC]
synonym: "aldehydes" EXACT IUPAC_NAME [IUPAC]
synonym: "aldehydes" RELATED [ChEBI]
synonym: "aldehydum" RELATED [ChEBI]
synonym: "an aldehyde" RELATED [UniProt]
synonym: "RC(=O)H" RELATED [IUPAC]
synonym: "RCHO" RELATED [KEGG_COMPOUND]
xref: KEGG:C00071
is_a: CHEBI:36586 ! carbonyl compound
relationship: BFO:0000051 CHEBI:42485 ! has part formyl group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHOR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "29.01800" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.00274" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([*])=O" xsd:string

[Term]
id: CHEBI:17544
name: hydrogencarbonate
namespace: chebi_ontology
alt_id: CHEBI:13363
alt_id: CHEBI:22863
alt_id: CHEBI:40961
alt_id: CHEBI:5589
def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." []
subset: 3_STAR
synonym: "[CO2(OH)](-)" RELATED [IUPAC]
synonym: "Acid carbonate" RELATED [KEGG_COMPOUND]
synonym: "Bicarbonate" RELATED [KEGG_COMPOUND]
synonym: "BICARBONATE ION" RELATED [PDBeChem]
synonym: "HCO3(-)" RELATED [IUPAC]
synonym: "HCO3-" RELATED [KEGG_COMPOUND]
synonym: "hydrogen carbonate" RELATED [PDBeChem]
synonym: "hydrogen(trioxidocarbonate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND]
synonym: "hydrogencarbonate" EXACT [UniProt]
synonym: "hydrogencarbonate" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogencarbonate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentrioxocarbonate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentrioxocarbonate(IV)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxidodioxidocarbonate(1-)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3903504 {source="Beilstein"}
xref: CAS:71-52-3 {source="ChemIDplus"}
xref: Gmelin:49249 {source="Gmelin"}
xref: HMDB:HMDB0000595
xref: KEGG:C00288
xref: MetaCyc:HCO3
xref: PDBeChem:BCT
xref: PMID:17215880 {source="Europe PMC"}
xref: PMID:17505962 {source="Europe PMC"}
xref: PMID:18439416 {source="Europe PMC"}
xref: PMID:28732801 {source="Europe PMC"}
xref: PMID:29150416 {source="Europe PMC"}
xref: PMID:29460248 {source="Europe PMC"}
xref: PMID:29466234 {source="Europe PMC"}
xref: PMID:4208463 {source="Europe PMC"}
xref: Wikipedia:Bicarbonate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35604 ! carbon oxoanion
relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate
relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "61.01684" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.99312" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([O-])=O" xsd:string

[Term]
id: CHEBI:17568
name: uracil
namespace: chebi_ontology
alt_id: CHEBI:15288
alt_id: CHEBI:27210
alt_id: CHEBI:46375
alt_id: CHEBI:9882
def: "A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription." []
subset: 3_STAR
synonym: "2,4(1H,3H)-pyrimidinedione" RELATED [NIST_Chemistry_WebBook]
synonym: "2,4-Dioxopyrimidine" RELATED [HMDB]
synonym: "2,4-Pyrimidinedione" RELATED [HMDB]
synonym: "pyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC]
synonym: "U" RELATED [ChEBI]
synonym: "Ura" RELATED [CBN]
synonym: "URACIL" EXACT [PDBeChem]
synonym: "Uracil" EXACT [KEGG_COMPOUND]
synonym: "uracil" EXACT [UniProt]
synonym: "Urazil" RELATED [ChEBI]
xref: Beilstein:606623 {source="Beilstein"}
xref: CAS:66-22-8 {source="NIST Chemistry WebBook"}
xref: CAS:66-22-8 {source="KEGG COMPOUND"}
xref: CAS:66-22-8 {source="ChemIDplus"}
xref: DrugBank:DB03419
xref: Gmelin:2896 {source="Gmelin"}
xref: HMDB:HMDB0000300
xref: KEGG:C00106
xref: KEGG:D00027
xref: KNApSAcK:C00001513
xref: MetaCyc:URACIL
xref: PDBeChem:URA
xref: PMID:11279060 {source="Europe PMC"}
xref: PMID:12855717 {source="Europe PMC"}
xref: PMID:15274295 {source="Europe PMC"}
xref: PMID:16834123 {source="Europe PMC"}
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:18533995 {source="Europe PMC"}
xref: PMID:18815805 {source="Europe PMC"}
xref: PMID:19175333 {source="Europe PMC"}
xref: PMID:22020693 {source="Europe PMC"}
xref: PMID:22074393 {source="Europe PMC"}
xref: PMID:22120518 {source="Europe PMC"}
xref: PMID:22171528 {source="Europe PMC"}
xref: PMID:22237209 {source="Europe PMC"}
xref: PMID:22299724 {source="Europe PMC"}
xref: PMID:22356544 {source="Europe PMC"}
xref: PMID:22447672 {source="Europe PMC"}
xref: PMID:22483865 {source="Europe PMC"}
xref: PMID:22567906 {source="Europe PMC"}
xref: PMID:22685418 {source="Europe PMC"}
xref: PMID:3654008 {source="Europe PMC"}
xref: Reaxys:606623 {source="Reaxys"}
xref: Wikipedia:Uracil
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:26432 ! pyrimidine nucleobase
is_a: CHEBI:38337 ! pyrimidone
relationship: is_tautomer_of CHEBI:43254 ! (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one
relationship: RO:0000087 CHEBI:50266 ! has role prodrug
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H4N2O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ISAKRJDGNUQOIC-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "112.08684" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "112.02728" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=c1cc[nH]c(=O)[nH]1" xsd:string

[Term]
id: CHEBI:17578
name: toluene
namespace: chebi_ontology
alt_id: CHEBI:15248
alt_id: CHEBI:27022
alt_id: CHEBI:44023
alt_id: CHEBI:9624
def: "The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent." []
subset: 3_STAR
synonym: "methylbenzene" RELATED [PDBeChem]
synonym: "phenylmethane" RELATED [ChemIDplus]
synonym: "Toluen" RELATED [NIST_Chemistry_WebBook]
synonym: "TOLUENE" EXACT [PDBeChem]
synonym: "Toluene" EXACT [KEGG_COMPOUND]
synonym: "toluene" EXACT [ChEBI]
synonym: "toluene" EXACT [UniProt]
synonym: "toluene" EXACT IUPAC_NAME [IUPAC]
synonym: "Toluol" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:635760 {source="Beilstein"}
xref: CAS:108-88-3 {source="KEGG COMPOUND"}
xref: CAS:108-88-3 {source="NIST Chemistry WebBook"}
xref: CAS:108-88-3 {source="ChemIDplus"}
xref: DrugBank:DB01900
xref: Gmelin:2456 {source="Gmelin"}
xref: KEGG:C01455
xref: PDBeChem:MBN
xref: PMID:11182169 {source="Europe PMC"}
xref: PMID:11314682 {source="Europe PMC"}
xref: PMID:11846266 {source="Europe PMC"}
xref: PMID:11991009 {source="Europe PMC"}
xref: PMID:12062755 {source="Europe PMC"}
xref: PMID:12213539 {source="Europe PMC"}
xref: PMID:12237258 {source="Europe PMC"}
xref: PMID:12784113 {source="Europe PMC"}
xref: PMID:12876426 {source="Europe PMC"}
xref: PMID:14512097 {source="Europe PMC"}
xref: PMID:14559343 {source="Europe PMC"}
xref: PMID:14605898 {source="Europe PMC"}
xref: PMID:15015825 {source="Europe PMC"}
xref: PMID:15019953 {source="Europe PMC"}
xref: PMID:15119846 {source="Europe PMC"}
xref: PMID:15193425 {source="Europe PMC"}
xref: PMID:15542760 {source="Europe PMC"}
xref: PMID:15567510 {source="Europe PMC"}
xref: PMID:15695158 {source="Europe PMC"}
xref: PMID:15796064 {source="Europe PMC"}
xref: PMID:16316648 {source="Europe PMC"}
xref: PMID:16348226 {source="Europe PMC"}
xref: PMID:16601996 {source="Europe PMC"}
xref: PMID:17145141 {source="Europe PMC"}
xref: PMID:17175136 {source="Europe PMC"}
xref: PMID:17497535 {source="Europe PMC"}
xref: PMID:17725881 {source="Europe PMC"}
xref: PMID:18397809 {source="Europe PMC"}
xref: PMID:18832024 {source="Europe PMC"}
xref: PMID:19261054 {source="Europe PMC"}
xref: PMID:19384711 {source="Europe PMC"}
xref: PMID:19429395 {source="Europe PMC"}
xref: PMID:19635754 {source="Europe PMC"}
xref: PMID:19765629 {source="Europe PMC"}
xref: PMID:19825861 {source="Europe PMC"}
xref: PMID:19928203 {source="Europe PMC"}
xref: PMID:19969016 {source="Europe PMC"}
xref: PMID:20347282 {source="Europe PMC"}
xref: PMID:20837561 {source="Europe PMC"}
xref: PMID:21430649 {source="Europe PMC"}
xref: PMID:21655021 {source="Europe PMC"}
xref: PMID:21731073 {source="Europe PMC"}
xref: PMID:21802510 {source="Europe PMC"}
xref: PMID:21840036 {source="Europe PMC"}
xref: Reaxys:635760 {source="Reaxys"}
xref: UM-BBD_compID:c0114 {source="UM-BBD"}
xref: Wikipedia:Toluene
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:27024 ! toluenes
is_a: CHEBI:38975 ! methylbenzene
relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent
relationship: RO:0000087 CHEBI:48873 ! has role cholinergic antagonist
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:62803 ! has role fuel additive
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H8" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YXFVVABEGXRONW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "92.13842" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "92.06260" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1ccccc1" xsd:string

[Term]
id: CHEBI:17590
name: octane
namespace: chebi_ontology
alt_id: CHEBI:14680
alt_id: CHEBI:25465
alt_id: CHEBI:25645
alt_id: CHEBI:44621
alt_id: CHEBI:7723
def: "A straight chain alkane composed of 8 carbon atoms." []
subset: 3_STAR
synonym: "CH3-[CH2]6-CH3" RELATED [IUPAC]
synonym: "N-OCTANE" RELATED [PDBeChem]
synonym: "n-Octane" RELATED [KEGG_COMPOUND]
synonym: "n-Oktan" RELATED [ChEBI]
synonym: "Octane" EXACT [KEGG_COMPOUND]
synonym: "octane" EXACT IUPAC_NAME [IUPAC]
synonym: "octane" EXACT [UniProt]
synonym: "Oktan" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1696875 {source="Beilstein"}
xref: CAS:111-65-9 {source="KEGG COMPOUND"}
xref: CAS:111-65-9 {source="NIST Chemistry WebBook"}
xref: CAS:111-65-9 {source="ChemIDplus"}
xref: DrugBank:DB02440
xref: Gmelin:82412 {source="Gmelin"}
xref: HMDB:HMDB0001485
xref: KEGG:C01387
xref: LIPID_MAPS_instance:LMFA11000002 {source="LIPID MAPS"}
xref: MetaCyc:CPD-148
xref: PDBeChem:OCT
xref: PMID:11255151 {source="Europe PMC"}
xref: PMID:24354334 {source="Europe PMC"}
xref: Reaxys:1696875 {source="Reaxys"}
xref: UM-BBD_compID:c0044 {source="UM-BBD"}
xref: Wikipedia:Octane
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:18310 ! alkane
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H18" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H18/c1-3-5-7-8-6-4-2/h3-8H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TVMXDCGIABBOFY-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "114.22852" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "114.14085" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCC" xsd:string

[Term]
id: CHEBI:17594
name: hydroquinone
namespace: chebi_ontology
alt_id: CHEBI:14416
alt_id: CHEBI:24645
alt_id: CHEBI:5793
def: "A benzenediol comprising benzene core carrying two hydroxy substituents para to each other." []
subset: 3_STAR
synonym: "1,4-Benzenediol" RELATED [KEGG_COMPOUND]
synonym: "1,4-Dihydroxybenzene" RELATED [KEGG_COMPOUND]
synonym: "4-Hydroxyphenol" RELATED [KEGG_COMPOUND]
synonym: "Benzene-1,4-diol" RELATED [KEGG_COMPOUND]
synonym: "benzene-1,4-diol" EXACT IUPAC_NAME [IUPAC]
synonym: "Eldoquin" RELATED [ChemIDplus]
synonym: "Hydroquinone" EXACT [KEGG_COMPOUND]
synonym: "hydroquinone" EXACT [UniProt]
synonym: "p-Benzenediol" RELATED [KEGG_COMPOUND]
synonym: "p-Hydroquinone" RELATED [KEGG_COMPOUND]
synonym: "p-hydroxyphenol" RELATED [NIST_Chemistry_WebBook]
synonym: "Quinol" RELATED [KEGG_COMPOUND]
xref: Beilstein:605970 {source="Beilstein"}
xref: CAS:123-31-9 {source="ChemIDplus"}
xref: CAS:123-31-9 {source="NIST Chemistry WebBook"}
xref: CAS:123-31-9 {source="KEGG COMPOUND"}
xref: Drug_Central:3282 {source="DrugCentral"}
xref: Gmelin:2742 {source="Gmelin"}
xref: HMDB:HMDB0002434
xref: KEGG:C00530
xref: KEGG:C15603
xref: KEGG:D00073
xref: KNApSAcK:C00002656
xref: MetaCyc:HYDROQUINONE
xref: PMID:11170505 {source="Europe PMC"}
xref: PMID:12213471 {source="Europe PMC"}
xref: PMID:1395635 {source="Europe PMC"}
xref: PMID:15618234 {source="Europe PMC"}
xref: PMID:15894107 {source="Europe PMC"}
xref: PMID:1899343 {source="Europe PMC"}
xref: PMID:19148301 {source="Europe PMC"}
xref: PMID:24407054 {source="Europe PMC"}
xref: PMID:24858384 {source="Europe PMC"}
xref: PMID:25586344 {source="Europe PMC"}
xref: PPDB:1503
xref: Reaxys:605970 {source="Reaxys"}
xref: UM-BBD_compID:c0091 {source="UM-BBD"}
xref: Wikipedia:Hydroquinone
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:17701 ! benzenediol
is_a: CHEBI:24646 ! hydroquinones
relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:85046 ! has role skin lightening agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QIGBRXMKCJKVMJ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "110.11064" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "110.03678" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Oc1ccc(O)cc1" xsd:string

[Term]
id: CHEBI:176497
name: geroprotector
namespace: chebi_ontology
def: "Any compound that supports healthy aging, slows the biological aging process, or extends lifespan." []
subset: 3_STAR
synonym: "anti-aging agent" RELATED [ChEBI]
synonym: "anti-aging agents" RELATED [ChEBI]
synonym: "anti-aging drug" RELATED [ChEBI]
synonym: "anti-aging drugs" RELATED [ChEBI]
synonym: "geroprotective agent" RELATED [ChEBI]
synonym: "geroprotective agents" RELATED [ChEBI]
synonym: "geroprotectors" RELATED [ChEBI]
xref: PMID:23372317 {source="Europe PMC"}
xref: PMID:28580190 {source="Europe PMC"}
xref: PMID:30885572 {source="Europe PMC"}
xref: PMID:33144142 {source="Europe PMC"}
xref: PMID:33973253 {source="Europe PMC"}
xref: PMID:34606237 {source="Europe PMC"}
xref: Wikipedia:Geroprotector
is_a: CHEBI:50267 ! protective agent

[Term]
id: CHEBI:176842
name: vitamin B9
namespace: chebi_ontology
def: "Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin." []
subset: 3_STAR
synonym: "folate vitamer" RELATED [ChEBI]
synonym: "folate vitamers" RELATED [ChEBI]
synonym: "vitamin B-9" RELATED [ChEBI]
synonym: "vitamin B9" EXACT [ChEBI]
synonym: "vitamin B9 vitamer" RELATED [ChEBI]
synonym: "vitamin B9 vitamers" RELATED [ChEBI]
synonym: "vitamins B9" RELATED [ChEBI]
is_a: CHEBI:75769 ! B vitamin

[Term]
id: CHEBI:17701
name: benzenediol
namespace: chebi_ontology
alt_id: CHEBI:13878
alt_id: CHEBI:3027
subset: 3_STAR
synonym: "Benzenediol" EXACT [KEGG_COMPOUND]
synonym: "benzenediol" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydroxybenzene" RELATED [ChEBI]
xref: CAS:12385-08-9 {source="ChemIDplus"}
xref: CAS:12385-08-9 {source="KEGG COMPOUND"}
xref: KEGG:C01785
is_a: CHEBI:33570 ! benzenediols
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "110.111" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "110.03678" xsd:string

[Term]
id: CHEBI:17748
name: thymidine
namespace: chebi_ontology
alt_id: CHEBI:15244
alt_id: CHEBI:19273
alt_id: CHEBI:45782
alt_id: CHEBI:45834
alt_id: CHEBI:45917
alt_id: CHEBI:9579
def: "A pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase." []
subset: 3_STAR
synonym: "1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione" RELATED [ChEBI]
synonym: "2'-deoxy-5-methyluridine" RELATED [ChemIDplus]
synonym: "2'-deoxythymidine" RELATED [ChemIDplus]
synonym: "2'-thymidine" RELATED [ChEBI]
synonym: "5-methyl-2'-deoxyuridine" RELATED [ChemIDplus]
synonym: "Deoxythymidine" RELATED [KEGG_COMPOUND]
synonym: "dThd" RELATED [CBN]
synonym: "T" RELATED [ChEBI]
synonym: "THYMIDINE" EXACT [PDBeChem]
synonym: "Thymidine" EXACT [KEGG_COMPOUND]
synonym: "thymidine" EXACT IUPAC_NAME [IUPAC]
synonym: "thymidine" EXACT [UniProt]
synonym: "thymine 2'-deoxyriboside" RELATED [ChEBI]
xref: Beilstein:89285 {source="Beilstein"}
xref: CAS:50-89-5 {source="KEGG COMPOUND"}
xref: CAS:50-89-5 {source="ChemIDplus"}
xref: DrugBank:DB04485
xref: Gmelin:282610 {source="Gmelin"}
xref: HMDB:HMDB0000273
xref: KEGG:C00214
xref: KNApSAcK:C00019698
xref: MetaCyc:THYMIDINE
xref: PDBeChem:THM
xref: PMID:22770225 {source="Europe PMC"}
xref: PMID:2559771 {source="Europe PMC"}
xref: Reaxys:89285 {source="Reaxys"}
xref: Wikipedia:Thymidine
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside
relationship: has_functional_parent CHEBI:17821 ! thymine
relationship: is_enantiomer_of CHEBI:63624 ! telbivudine
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H14N2O5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IQFYYKKMVGJFEH-XLPZGREQSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "242.22860" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "242.09027" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O" xsd:string

[Term]
id: CHEBI:17792
name: organohalogen compound
namespace: chebi_ontology
alt_id: CHEBI:13444
alt_id: CHEBI:36684
alt_id: CHEBI:8767
def: "A compound containing at least one carbon-halogen bond (where X is a halogen atom)." []
subset: 3_STAR
synonym: "organic halide" RELATED [KEGG_COMPOUND]
synonym: "organic halides" RELATED [ChEBI]
synonym: "organohalogen compounds" RELATED [ChEBI]
synonym: "RX" RELATED [UniProt]
synonym: "RX" RELATED [KEGG_COMPOUND]
xref: KEGG:C01322
xref: MetaCyc:Organohalogen-Compounds
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:37578 ! halide
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "RX" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "**" xsd:string

[Term]
id: CHEBI:17821
name: thymine
namespace: chebi_ontology
alt_id: CHEBI:15247
alt_id: CHEBI:27004
alt_id: CHEBI:46017
alt_id: CHEBI:9580
def: "A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group." []
subset: 3_STAR
synonym: "2,4-dihydroxy-5-methylpyrimidine" RELATED [NIST_Chemistry_WebBook]
synonym: "5-methyl-2,4(1H,3H)-pyrimidinedione" RELATED [NIST_Chemistry_WebBook]
synonym: "5-methylpyrimidine-2,4(1H,3H)-dione" RELATED [IUPAC]
synonym: "5-Methyluracil" RELATED [KEGG_COMPOUND]
synonym: "5-methyluracil" RELATED [NIST_Chemistry_WebBook]
synonym: "T" RELATED [ChEBI]
synonym: "Thy" RELATED [CBN]
synonym: "Thymin" RELATED [ChemIDplus]
synonym: "THYMINE" EXACT [PDBeChem]
synonym: "Thymine" EXACT [KEGG_COMPOUND]
synonym: "thymine" EXACT [UniProt]
synonym: "thymine" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:607626 {source="Beilstein"}
xref: CAS:65-71-4 {source="NIST Chemistry WebBook"}
xref: CAS:65-71-4 {source="ChemIDplus"}
xref: CAS:65-71-4 {source="KEGG COMPOUND"}
xref: DrugBank:DB03462
xref: Gmelin:278790 {source="Gmelin"}
xref: KEGG:C00178
xref: KNApSAcK:C00001511
xref: PDBeChem:TDR
xref: PMID:23237383 {source="Europe PMC"}
xref: Wikipedia:Thymine
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:26432 ! pyrimidine nucleobase
is_a: CHEBI:38337 ! pyrimidone
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H6N2O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RWQNBRDOKXIBIV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "126.11342" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "126.04293" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1c[nH]c(=O)[nH]c1=O" xsd:string

[Term]
id: CHEBI:17883
name: hydrogen chloride
namespace: chebi_ontology
alt_id: CHEBI:13364
alt_id: CHEBI:24635
alt_id: CHEBI:5590
def: "A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms." []
subset: 3_STAR
synonym: "[HCl]" RELATED [IUPAC]
synonym: "chlorane" EXACT IUPAC_NAME [IUPAC]
synonym: "chloridohydrogen" EXACT IUPAC_NAME [IUPAC]
synonym: "chlorure d'hydrogene" RELATED [ChEBI]
synonym: "Chlorwasserstoff" RELATED [ChEBI]
synonym: "cloruro de hidrogeno" RELATED [ChEBI]
synonym: "HCl" RELATED [KEGG_COMPOUND]
synonym: "hydrochloric acid" RELATED [ChemIDplus]
synonym: "Hydrochloride" RELATED [KEGG_COMPOUND]
synonym: "Hydrogen chloride" EXACT [KEGG_COMPOUND]
synonym: "hydrogen chloride" EXACT IUPAC_NAME [IUPAC]
synonym: "Hydrogenchlorid" RELATED [ChEBI]
synonym: "Wasserstoffchlorid" RELATED [ChEBI]
xref: CAS:7647-01-0 {source="ChemIDplus"}
xref: CAS:7647-01-0 {source="NIST Chemistry WebBook"}
xref: CAS:7647-01-0 {source="KEGG COMPOUND"}
xref: Drug_Central:4568 {source="DrugCentral"}
xref: Gmelin:322 {source="Gmelin"}
xref: HMDB:HMDB0002306
xref: KEGG:C01327
xref: KEGG:D02057
xref: MetaCyc:HCL
xref: PMID:15823700 {source="Europe PMC"}
xref: PMID:17492841 {source="Europe PMC"}
xref: PMID:22804993 {source="Europe PMC"}
xref: Reaxys:1098214 {source="Reaxys"}
xref: Wikipedia:HCl
xref: Wikipedia:Hydrochloric_acid
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:18140 ! hydrogen halide
is_a: CHEBI:23117 ! chlorine molecular entity
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: is_conjugate_acid_of CHEBI:17996 ! chloride
relationship: is_conjugate_base_of CHEBI:50315 ! chloronium
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "ClH" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HCl" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH/h1H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VEXZGXHMUGYJMC-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "36.46064" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "35.97668" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cl[H]" xsd:string

[Term]
id: CHEBI:17891
name: donor
namespace: chebi_ontology
alt_id: CHEBI:14202
alt_id: CHEBI:4697
def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." []
subset: 3_STAR
synonym: "Donator" RELATED [ChEBI]
synonym: "donneur" RELATED [ChEBI]
synonym: "Donor" EXACT [KEGG_COMPOUND]
xref: KEGG:C01351
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:17967
name: urethane
namespace: chebi_ontology
alt_id: CHEBI:15295
alt_id: CHEBI:27225
alt_id: CHEBI:9892
def: "A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages." []
subset: 3_STAR
synonym: "carbamic acid ethyl ester" RELATED [ChEBI]
synonym: "Ethyl carbamate" RELATED [KEGG_COMPOUND]
synonym: "ethyl carbamate" EXACT IUPAC_NAME [IUPAC]
synonym: "Urethane" EXACT [KEGG_COMPOUND]
synonym: "urethane" EXACT [UniProt]
xref: CAS:51-79-6 {source="KEGG COMPOUND"}
xref: DrugBank:DB04827
xref: HMDB:HMDB0031219
xref: KEGG:C01537
xref: LINCS:LSM-37020
xref: PMID:15790490 {source="Europe PMC"}
xref: PMID:24386880 {source="Europe PMC"}
xref: Reaxys:635810 {source="Reaxys"}
xref: Wikipedia:Ethyl_carbamate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:23003 ! carbamate ester
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2/c1-2-6-3(4)5/h2H2,1H3,(H2,4,5)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JOYRKODLDBILNP-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "89.09322" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.04768" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCOC(N)=O" xsd:string

[Term]
id: CHEBI:17996
name: chloride
namespace: chebi_ontology
alt_id: CHEBI:13291
alt_id: CHEBI:13970
alt_id: CHEBI:3616
alt_id: CHEBI:3731
alt_id: CHEBI:48804
def: "A halide anion formed when chlorine picks up an electron to form an an anion." []
subset: 3_STAR
synonym: "Chloride" EXACT [KEGG_COMPOUND]
synonym: "chloride" EXACT [UniProt]
synonym: "chloride" EXACT IUPAC_NAME [IUPAC]
synonym: "CHLORIDE ION" RELATED [PDBeChem]
synonym: "Chloride ion" RELATED [KEGG_COMPOUND]
synonym: "Chloride(1-)" RELATED [ChemIDplus]
synonym: "chloride(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "Chlorine anion" RELATED [NIST_Chemistry_WebBook]
synonym: "Cl(-)" RELATED [IUPAC]
synonym: "Cl-" RELATED [KEGG_COMPOUND]
xref: Beilstein:3587171 {source="Beilstein"}
xref: CAS:16887-00-6 {source="ChemIDplus"}
xref: CAS:16887-00-6 {source="NIST Chemistry WebBook"}
xref: CAS:16887-00-6 {source="KEGG COMPOUND"}
xref: Gmelin:14910 {source="Gmelin"}
xref: KEGG:C00115
xref: KEGG:C00698
xref: PDBeChem:CL
xref: UM-BBD_compID:c0884 {source="UM-BBD"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:16042 ! halide anion
is_a: CHEBI:33432 ! monoatomic chlorine
relationship: is_conjugate_base_of CHEBI:17883 ! hydrogen chloride
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH/h1H/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VEXZGXHMUGYJMC-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "35.45270" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96940" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cl-]" xsd:string

[Term]
id: CHEBI:18059
name: lipid
namespace: chebi_ontology
alt_id: CHEBI:14517
alt_id: CHEBI:25054
alt_id: CHEBI:6486
def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." []
subset: 3_STAR
synonym: "Lipid" EXACT [KEGG_COMPOUND]
synonym: "lipids" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C01356
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:18140
name: hydrogen halide
namespace: chebi_ontology
alt_id: CHEBI:13368
alt_id: CHEBI:37140
alt_id: CHEBI:5599
subset: 3_STAR
synonym: "hydrogen halide" EXACT [IUPAC]
synonym: "hydrogen halides" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogen halides" RELATED [ChEBI]
is_a: CHEBI:33405 ! hydracid
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HX" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "1.008" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.00783" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*[H]" xsd:string

[Term]
id: CHEBI:18237
name: glutamic acid
namespace: chebi_ontology
alt_id: CHEBI:24314
alt_id: CHEBI:5431
def: "An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2." []
subset: 3_STAR
synonym: "2-Aminoglutaric acid" RELATED [KEGG_COMPOUND]
synonym: "2-aminopentanedioic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "DL-Glutamic acid" RELATED [KEGG_DRUG]
synonym: "DL-Glutaminic acid" RELATED [KEGG_COMPOUND]
synonym: "E" RELATED [ChEBI]
synonym: "Glu" RELATED [ChEBI]
synonym: "Glutamate" RELATED [KEGG_COMPOUND]
synonym: "Glutamic acid" EXACT [KEGG_COMPOUND]
synonym: "glutamic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Glutaminic acid" RELATED [KEGG_COMPOUND]
synonym: "Glutaminsaeure" RELATED [ChEBI]
xref: Beilstein:1723799 {source="Beilstein"}
xref: CAS:617-65-2 {source="ChemIDplus"}
xref: CAS:617-65-2 {source="NIST Chemistry WebBook"}
xref: CAS:617-65-2 {source="KEGG COMPOUND"}
xref: Gmelin:101971 {source="Gmelin"}
xref: KEGG:C00302
xref: KEGG:D04341
xref: KNApSAcK:C00001358
xref: KNApSAcK:C00019577
xref: PMID:15739367 {source="Europe PMC"}
xref: PMID:17190852 {source="Europe PMC"}
xref: PMID:24616376 {source="Europe PMC"}
xref: PMID:24984001 {source="Europe PMC"}
xref: Reaxys:1723799 {source="Reaxys"}
xref: Wikipedia:Glutamic_acid
is_a: CHEBI:26167 ! polar amino acid
is_a: CHEBI:33704 ! alpha-amino acid
relationship: BFO:0000051 CHEBI:50329 ! has part 2-carboxyethyl group
relationship: is_conjugate_acid_of CHEBI:14321 ! glutamate(1-)
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "147.12930" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "147.05316" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CCC(O)=O)C(O)=O" xsd:string

[Term]
id: CHEBI:18254
name: ribonucleoside
namespace: chebi_ontology
alt_id: CHEBI:13014
alt_id: CHEBI:13015
alt_id: CHEBI:13685
alt_id: CHEBI:21085
alt_id: CHEBI:26560
alt_id: CHEBI:4240
alt_id: CHEBI:8844
def: "Any nucleoside where the sugar component is D-ribose." []
subset: 3_STAR
synonym: "a ribonucleoside" RELATED [UniProt]
synonym: "Ribonucleoside" EXACT [KEGG_COMPOUND]
synonym: "ribonucleosides" RELATED [ChEBI]
xref: KEGG:C00911
is_a: CHEBI:33838 ! nucleoside
is_a: CHEBI:47019 ! dihydroxytetrahydrofuran
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O4R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "133.123" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "133.05008" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1O" xsd:string

[Term]
id: CHEBI:18274
name: 2'-deoxyribonucleoside
namespace: chebi_ontology
alt_id: CHEBI:1083
alt_id: CHEBI:11394
alt_id: CHEBI:11567
alt_id: CHEBI:11568
alt_id: CHEBI:19259
alt_id: CHEBI:19560
alt_id: CHEBI:4421
subset: 3_STAR
synonym: "2'-Deoxynucleoside" RELATED [KEGG_COMPOUND]
synonym: "2'-deoxyribonucleosides" RELATED [ChEBI]
synonym: "2-Deoxy-D-ribosyl-base" RELATED [KEGG_COMPOUND]
synonym: "a 2'-deoxyribonucleoside" RELATED [UniProt]
synonym: "Deoxynucleoside" RELATED [KEGG_COMPOUND]
xref: KEGG:C02269
xref: KEGG:C03216
is_a: CHEBI:23636 ! deoxyribonucleoside
is_a: CHEBI:47018 ! monohydroxytetrahydrofuran
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O3R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "117.123" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "117.05517" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@@H]([*])C[C@@H]1O" xsd:string

[Term]
id: CHEBI:18282
name: nucleobase
namespace: chebi_ontology
alt_id: CHEBI:13873
alt_id: CHEBI:25598
alt_id: CHEBI:2995
def: "That part of DNA or RNA that may be involved in pairing." []
subset: 3_STAR
synonym: "Base" RELATED [KEGG_COMPOUND]
synonym: "nucleobases" RELATED [ChEBI]
xref: KEGG:C00701
xref: Wikipedia:Nucleobase
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:18310
name: alkane
namespace: chebi_ontology
alt_id: CHEBI:13435
alt_id: CHEBI:22317
alt_id: CHEBI:2576
def: "An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms." []
subset: 3_STAR
synonym: "alcane" RELATED [IUPAC]
synonym: "alcanes" RELATED [IUPAC]
synonym: "alcano" RELATED [IUPAC]
synonym: "alcanos" RELATED [IUPAC]
synonym: "Alkan" RELATED [ChEBI]
synonym: "Alkane" EXACT [KEGG_COMPOUND]
synonym: "alkane" EXACT IUPAC_NAME [IUPAC]
synonym: "alkanes" EXACT IUPAC_NAME [IUPAC]
synonym: "an alkane" RELATED [UniProt]
synonym: "RH" RELATED [KEGG_COMPOUND]
xref: KEGG:C01371
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:33653 ! aliphatic compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.035" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.02348" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[*]" xsd:string

[Term]
id: CHEBI:18367
name: phosphate(3-)
namespace: chebi_ontology
alt_id: CHEBI:14791
alt_id: CHEBI:45024
alt_id: CHEBI:7793
def: "A phosphate ion that is the conjugate base of hydrogenphosphate." []
subset: 3_STAR
synonym: "[PO4](3-)" RELATED [IUPAC]
synonym: "Orthophosphate" RELATED [KEGG_COMPOUND]
synonym: "Phosphate" RELATED [KEGG_COMPOUND]
synonym: "phosphate" EXACT IUPAC_NAME [IUPAC]
synonym: "PHOSPHATE ION" RELATED [PDBeChem]
synonym: "PO4(3-)" RELATED [IUPAC]
synonym: "tetraoxidophosphate(3-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxophosphate(3-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3903772 {source="Beilstein"}
xref: CAS:14265-44-2 {source="KEGG COMPOUND"}
xref: CAS:14265-44-2 {source="ChemIDplus"}
xref: Gmelin:1997 {source="Gmelin"}
xref: KEGG:C00009
xref: PDBeChem:PO4 {source="ChEBI"}
xref: Reaxys:3903772 {source="Reaxys"}
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79387 ! trivalent inorganic anion
relationship: is_conjugate_base_of CHEBI:43474 ! hydrogenphosphate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-K" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "94.97136" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "94.95507" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]P([O-])([O-])=O" xsd:string

[Term]
id: CHEBI:19024
name: 4-amino-3-hydroxynaphthalene-1-sulfonic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "1-amino-2-naphthol-4-sulfonic acid" RELATED [ChemIDplus]
synonym: "1-amino-4-sulfo-2-naphthol" RELATED [ChemIDplus]
synonym: "4-amino-3-hydroxynaphthalene-1-sulfonic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "4-amino-3-hydroxynaphthalene-1-sulphonic acid" RELATED [ChemIDplus]
xref: Beilstein:2697469 {source="Beilstein"}
xref: CAS:116-63-2 {source="NIST Chemistry WebBook"}
xref: CAS:116-63-2 {source="ChemIDplus"}
xref: Gmelin:241697 {source="Gmelin"}
is_a: CHEBI:36336 ! naphthalenesulfonic acid
is_a: CHEBI:38034 ! aminonaphthalene
relationship: has_functional_parent CHEBI:10432 ! 2-naphthol
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H9NO4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H9NO4S/c11-10-7-4-2-1-3-6(7)9(5-8(10)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RXCMFQDTWCCLBL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "239.24880" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "239.02523" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1c(O)cc(c2ccccc12)S(O)(=O)=O" xsd:string

[Term]
id: CHEBI:19032
name: 1-bromo-2-chloroethane
namespace: chebi_ontology
def: "A haloalkane that is bromoethane substituted by chlorine at position 2." []
subset: 3_STAR
synonym: "1,2-bromochloroethane" RELATED [NIST_Chemistry_WebBook]
synonym: "1,2-chlorobromoethane" RELATED [ChemIDplus]
synonym: "1-bromo-2-chloroethane" EXACT IUPAC_NAME [IUPAC]
synonym: "2-bromo-1-chloroethane" RELATED [ChemIDplus]
synonym: "2-bromoethyl chloride" RELATED [NIST_Chemistry_WebBook]
synonym: "2-chloroethyl bromide" RELATED [NIST_Chemistry_WebBook]
synonym: "beta-chloroethyl bromide" RELATED [NIST_Chemistry_WebBook]
synonym: "ethylene chlorobromide" RELATED [ChemIDplus]
xref: Beilstein:605265 {source="Beilstein"}
xref: CAS:107-04-0 {source="NIST Chemistry WebBook"}
xref: CAS:107-04-0 {source="ChemIDplus"}
xref: Gmelin:984479 {source="Gmelin"}
xref: PMID:6357525 {source="Europe PMC"}
xref: PMID:8200089 {source="Europe PMC"}
xref: Reaxys:605265 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24469 ! haloalkane
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:37141 ! organobromine compound
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4BrCl" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4BrCl/c3-1-2-4/h1-2H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IBYHHJPAARCAIE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "143.40986" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "141.91849" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "ClCCBr" xsd:string

[Term]
id: CHEBI:19255
name: pyrimidine 2'-deoxyribonucleoside
namespace: chebi_ontology
subset: 3_STAR
synonym: "pyrimidine 2'-deoxyribonucleosides" RELATED [ChEBI]
is_a: CHEBI:18274 ! 2'-deoxyribonucleoside
is_a: CHEBI:68472 ! pyrimidine deoxyribonucleoside

[Term]
id: CHEBI:19363
name: 2,5-bis(aziridin-1-yl)-1,4-benzoquinone
namespace: chebi_ontology
def: "A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups." []
subset: 3_STAR
synonym: "2,5,-bis(ethyleneimine)-1,4-benzoquinone" RELATED [ChEBI]
synonym: "2,5,-bisethylene-imine-1,4-benzoquinone" RELATED [ChEBI]
synonym: "2,5-bis(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione" RELATED [ChemIDplus]
synonym: "2,5-bis(1-aziridinyl)-p-benzoquinone" RELATED [ChemIDplus]
synonym: "2,5-bis(1-aziridynyl)benzoquinone" RELATED [ChemIDplus]
synonym: "2,5-bis(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione" EXACT IUPAC_NAME [IUPAC]
synonym: "2,5-bis(aziridino)-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "2,5-bis(aziridino)benzoquinone" RELATED [ChemIDplus]
synonym: "2,5-bis(ethyleneimino)-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "2,5-bis-ethyleniminobenzoquinone" RELATED [ChemIDplus]
synonym: "2,5-Bisaethyleniminobenzochinon-1,4" RELATED [ChEBI]
synonym: "2,5-bisethyleneiminebenzoquinone" RELATED [ChemIDplus]
synonym: "2,5-di(ethyleneimino)-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "2,5-diaziridinyl-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "3,6-diaziridinyl-1,4-benzoquinone" RELATED [ChEBI]
synonym: "DZQ" RELATED [ChEBI]
synonym: "ethylenimine quinone" RELATED [ChemIDplus]
synonym: "TW 13" RELATED [ChemIDplus]
xref: Beilstein:169182 {source="Beilstein"}
xref: CAS:526-62-5 {source="ChemIDplus"}
xref: PMID:10373575 {source="Europe PMC"}
xref: PMID:10978162 {source="Europe PMC"}
xref: PMID:11211879 {source="Europe PMC"}
xref: PMID:13415397 {source="Europe PMC"}
xref: PMID:17094478 {source="Europe PMC"}
xref: PMID:1751490 {source="Europe PMC"}
xref: PMID:8137269 {source="Europe PMC"}
xref: PMID:8461296 {source="Europe PMC"}
xref: PMID:9690517 {source="Europe PMC"}
xref: Reaxys:169182 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:132124 ! 1,4-benzoquinones
is_a: CHEBI:22681 ! aziridines
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H10N2O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H10N2O2/c13-9-6-8(12-3-4-12)10(14)5-7(9)11-1-2-11/h5-6H,1-4H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RCWJMKCTHJPXJV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "190.19868" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "190.07423" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1C=C(N2CC2)C(=O)C=C1N1CC1" xsd:string

[Term]
id: CHEBI:194095
name: mitomycin C(1-)
namespace: chebi_ontology
subset: 2_STAR
synonym: "mitomycin C" RELATED [UniProt]
xref: PMID:17461583 {source="SUBMITTER"}
is_a: CHEBI:50860 ! organic molecular entity
relationship: is_conjugate_base_of CHEBI:27504 ! mitomycin C
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17N4O5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H17N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/q-1/t7-,13-,15+/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TWSVZLVCDAGJHJ-QWPQFENESA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "333.325" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "333.12044" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=12C(C(=C(C(C1N3[C@@]([C-]2COC(N)=O)([C@@]4([C@](C3)(N4)[H])[H])OC)=O)C)N)=O" xsd:string

[Term]
id: CHEBI:19508
name: 2-chloroethyl methanesulfonate
namespace: chebi_ontology
subset: 1_STAR
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25223 ! methanesulfonate ester
is_a: CHEBI:36683 ! organochlorine compound
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent

[Term]
id: CHEBI:19579
name: 2-fluoroethyl methanesulfonate
namespace: chebi_ontology
subset: 1_STAR
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25223 ! methanesulfonate ester
is_a: CHEBI:37143 ! organofluorine compound
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent

[Term]
id: CHEBI:20552
name: 5-bromouracil
namespace: chebi_ontology
def: "A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen." []
subset: 3_STAR
synonym: "1,2,3,4-tetrahydro-5-bromo-2,4-pyrimidinedione" RELATED [NIST_Chemistry_WebBook]
synonym: "5-bromo-2,4(1H,3H)-pyrimidinedione" RELATED [NIST_Chemistry_WebBook]
synonym: "5-bromopyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC]
synonym: "5-BrU" RELATED [ChemIDplus]
synonym: "5-BU" RELATED [ChemIDplus]
synonym: "bromouracil" RELATED [ChemIDplus]
xref: Beilstein:127176 {source="Beilstein"}
xref: CAS:51-20-7 {source="ChemIDplus"}
xref: CAS:51-20-7 {source="NIST Chemistry WebBook"}
xref: Gmelin:486432 {source="Gmelin"}
xref: PMID:14522043 {source="Europe PMC"}
xref: PMID:28166217 {source="Europe PMC"}
xref: PMID:28320905 {source="Europe PMC"}
xref: PMID:3950402 {source="Europe PMC"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:39447 ! pyrimidines
is_a: CHEBI:67142 ! nucleobase analogue
relationship: has_functional_parent CHEBI:17568 ! uracil
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H3BrN2O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H3BrN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LQLQRFGHAALLLE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "190.98300" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "189.93779" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Brc1c[nH]c(=O)[nH]c1=O" xsd:string

[Term]
id: CHEBI:20553
name: 5-bromouridine
namespace: chebi_ontology
def: "A uridine having a bromo substituent at the 5-position." []
subset: 3_STAR
synonym: "1-beta-ribofuranosyl-5-bromo-uracil" RELATED [ChemIDplus]
synonym: "5-bromo-1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione" RELATED [ChEBI]
synonym: "5-bromouridine" EXACT [UniProt]
synonym: "5-bromouridine" EXACT IUPAC_NAME [IUPAC]
synonym: "5-bromouridine" EXACT [ChEBI]
synonym: "BrU" RELATED [ChEBI]
xref: Beilstein:33664 {source="Beilstein"}
xref: CAS:957-75-5 {source="ChemIDplus"}
xref: Gmelin:723432 {source="Gmelin"}
xref: PMID:3950402 {source="Europe PMC"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:27242 ! uridines
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11BrN2O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11BrN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AGFIRQJZCNVMCW-UAKXSSHOSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "323.09752" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "321.98005" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Br)c(=O)[nH]c1=O" xsd:string

[Term]
id: CHEBI:20702
name: 2-aminopurines
namespace: chebi_ontology
def: "Any aminopurine having the amino substituent at the 2-position." []
subset: 3_STAR
synonym: "2-aminopurines" EXACT [ChEBI]
is_a: CHEBI:22527 ! aminopurine

[Term]
id: CHEBI:20787
name: 7-bromomethyl-12-methyltetraphene
namespace: chebi_ontology
def: "A member of the class of tetraphenes that is tetraphene in which the hydrogens at positions 7 and 12 are replaced by bromomethyl and methyl groups, respectively." []
subset: 3_STAR
synonym: "7-(bromomethyl)-12-methyltetraphene" EXACT IUPAC_NAME [IUPAC]
synonym: "7-BrMe-12-MeBA" RELATED [ChEBI]
synonym: "7-bromomethyl-12-methylbenz[a]anthracene" RELATED [ChemIDplus]
synonym: "7-bromomethyl-12-methylbenzanthracene" RELATED [ChemIDplus]
xref: Beilstein:2056479 {source="Beilstein"}
xref: CAS:16238-56-5 {source="ChemIDplus"}
xref: PMID:10838135 {source="Europe PMC"}
xref: PMID:3114533 {source="Europe PMC"}
xref: PMID:8625451 {source="Europe PMC"}
xref: Reaxys:2056479 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:37141 ! organobromine compound
is_a: CHEBI:51067 ! tetraphenes
relationship: has_parent_hydride CHEBI:51348 ! tetraphene
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H15Br" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H15Br/c1-13-15-7-4-5-9-17(15)19(12-21)18-11-10-14-6-2-3-8-16(14)20(13)18/h2-11H,12H2,1H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IBWBDNBSIFGSLW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "335.23710" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "334.03571" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1c2ccccc2c(CBr)c2ccc3ccccc3c12" xsd:string

[Term]
id: CHEBI:21183
name: ICR-170
namespace: chebi_ontology
subset: 3_STAR
synonym: "acridine mustard" RELATED [ChemIDplus]
synonym: "ICR 170" RELATED [ChemIDplus]
synonym: "N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-1,3-propanediamine dihydrochloride" RELATED [ChemIDplus]
synonym: "N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine dihydrochloride" EXACT IUPAC_NAME [IUPAC]
xref: CAS:146-59-8 {source="ChemIDplus"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22213 ! acridines
relationship: BFO:0000051 CHEBI:37594 ! has part N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine
relationship: RO:0000087 CHEBI:24853 ! has role intercalator
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H27Cl4N3O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H25Cl2N3O.2ClH/c1-3-26(12-9-22)11-4-10-24-21-17-7-5-15(23)13-20(17)25-19-8-6-16(27-2)14-18(19)21;;/h5-8,13-14H,3-4,9-12H2,1-2H3,(H,24,25);2*1H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PWGOWIIEVDAYTC-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "479.26950" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "477.09082" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cl[H].Cl[H].CCN(CCCl)CCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12" xsd:string

[Term]
id: CHEBI:21184
name: Janus Green B chloride
namespace: chebi_ontology
subset: 3_STAR
synonym: "3-(diethylamino)-7-((4-(dimethylamino)phenyl)azo)-5-phenylphenazinium chloride" RELATED [ChemIDplus]
synonym: "3-(diethylamino)-7-((p-(dimethylamino)phenyl)azo)-5-phenylphenazinium chloride" RELATED [ChemIDplus]
synonym: "3-(diethylamino)-7-{(E)-[4-(dimethylamino)phenyl]diazenyl}-5-phenylphenazin-5-ium chloride" EXACT IUPAC_NAME [IUPAC]
synonym: "Janus Green B" RELATED [ChemIDplus]
synonym: "Janus Green V" RELATED [ChemIDplus]
xref: Beilstein:9748061 {source="Beilstein"}
xref: CAS:2869-83-2 {source="ChemIDplus"}
xref: Patent:US2882209
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:36094 ! organic chloride salt
relationship: BFO:0000051 CHEBI:51070 ! has part Janus Green B cation
relationship: RO:0000087 CHEBI:37958 ! has role dye
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C30H31ClN6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C30H31N6.ClH/c1-5-35(6-2)26-17-19-28-30(21-26)36(25-10-8-7-9-11-25)29-20-23(14-18-27(29)31-28)33-32-22-12-15-24(16-13-22)34(3)4;/h7-21H,5-6H2,1-4H3;1H/q+1;/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XXACTDWGHQXLGW-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "511.06028" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "510.22987" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cl-].CCN(CC)c1ccc2nc3ccc(cc3[n+](-c3ccccc3)c2c1)\\N=N\\c1ccc(cc1)N(C)C" xsd:string

[Term]
id: CHEBI:21644
name: N-acyl-L-amino acid
namespace: chebi_ontology
def: "Any N-acylamino acid having L-configuration." []
subset: 3_STAR
is_a: CHEBI:51569 ! N-acyl-amino acid
relationship: is_enantiomer_of CHEBI:15778 ! N-acyl-D-amino acid

[Term]
id: CHEBI:21731
name: N-glycosyl compound
namespace: chebi_ontology
def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond." []
subset: 3_STAR
synonym: "glycosylamine" EXACT IUPAC_NAME [IUPAC]
synonym: "glycosylamines" RELATED [IUPAC]
synonym: "N-glycoside" RELATED [ChEBI]
synonym: "N-glycosides" RELATED [ChEBI]
synonym: "N-glycosyl compounds" RELATED [ChEBI]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:63161 ! glycosyl compound

[Term]
id: CHEBI:21759
name: N-methyl-N'-nitro-N-nitrosoguanidine
namespace: chebi_ontology
alt_id: CHEBI:34872
def: "An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position" []
subset: 3_STAR
synonym: "1-Methyl-1-nitroso-3-nitroguanidine" RELATED [ChemIDplus]
synonym: "1-Methyl-3-nitro-1-nitrosoguanidine" RELATED [KEGG_COMPOUND]
synonym: "1-methyl-3-nitro-1-nitrosoguanidine" EXACT IUPAC_NAME [IUPAC]
synonym: "1-Nitroso-3-nitro-1-methylguanidine" RELATED [ChemIDplus]
synonym: "Methylnitronitrosoguanidine" RELATED [KEGG_COMPOUND]
synonym: "MNG" RELATED [ChemIDplus]
synonym: "MNNG" RELATED [KEGG_COMPOUND]
synonym: "MNNG" RELATED [ChemIDplus]
synonym: "N'-Nitro-N-nitroso-N-methylguanidine" RELATED [ChemIDplus]
synonym: "N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide" RELATED [NIST_Chemistry_WebBook]
synonym: "N-Methyl-N'-nitro-N-nitrosoguanidine" EXACT [KEGG_COMPOUND]
synonym: "N-Methyl-N-nitroso-N'-nitroguanidine" RELATED [ChEBI]
synonym: "N-Methyl-N-nitroso-N'-nitroguanidine" RELATED [ChemIDplus]
synonym: "N-Methyl-N-nitrosonitroguanidin" RELATED [ChEBI]
synonym: "N-Nitroso-N-methyl-N'-nitroguanidine" RELATED [ChemIDplus]
xref: Beilstein:1779490 {source="Beilstein"}
xref: CAS:70-25-7 {source="NIST Chemistry WebBook"}
xref: CAS:70-25-7 {source="KEGG COMPOUND"}
xref: CAS:70-25-7 {source="ChemIDplus"}
xref: KEGG:C14592
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35800 ! nitroso compound
relationship: has_functional_parent CHEBI:39179 ! nitroguanidine
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H5N5O3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VZUNGTLZRAYYDE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "147.09280" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "147.03924" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(N=O)C(=N)N[N+]([O-])=O" xsd:string

[Term]
id: CHEBI:22025
name: S-2-chloroethylcysteine
namespace: chebi_ontology
subset: 1_STAR
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:23509 ! cysteine derivative
is_a: CHEBI:36683 ! organochlorine compound
relationship: RO:0000087 CHEBI:25435 ! has role mutagen

[Term]
id: CHEBI:22063
name: sulfoxide
namespace: chebi_ontology
alt_id: CHEBI:35813
def: "An organosulfur compound having the structure R2S=O or R2C=S=O (R =/= H)." []
subset: 3_STAR
synonym: "S-oxides" RELATED [ChEBI]
synonym: "sulfoxide" EXACT [ChEBI]
synonym: "sulfoxides" RELATED [ChEBI]
is_a: CHEBI:33261 ! organosulfur compound

[Term]
id: CHEBI:22160
name: acetamides
namespace: chebi_ontology
def: "Compounds with the general formula RNHC(=O)CH3." []
subset: 3_STAR
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:22213
name: acridines
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:39206 ! dibenzopyridine

[Term]
id: CHEBI:22221
name: acyl group
namespace: chebi_ontology
def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
subset: 3_STAR
synonym: "acyl group" EXACT [IUPAC]
synonym: "acyl groups" RELATED [ChEBI]
synonym: "alkanoyl" EXACT IUPAC_NAME [IUPAC]
synonym: "alkanoyl group" RELATED [ChEBI]
synonym: "groupe acyle" RELATED [IUPAC]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:22314
name: alkali metal atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "alkali metal" RELATED [ChEBI]
synonym: "alkali metals" EXACT IUPAC_NAME [IUPAC]
synonym: "Alkalimetall" RELATED [ChEBI]
synonym: "Alkalimetalle" RELATED [ChEBI]
synonym: "metal alcalin" RELATED [ChEBI]
synonym: "metal alcalino" RELATED [ChEBI]
synonym: "metales alcalinos" RELATED [ChEBI]
synonym: "metaux alcalins" RELATED [ChEBI]
is_a: CHEBI:33318 ! main group element atom
is_a: CHEBI:33521 ! metal atom
is_a: CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:22315
name: alkaloid
namespace: chebi_ontology
def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is  exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." []
subset: 3_STAR
synonym: "alcaloide" RELATED [ChEBI]
synonym: "alcaloides" RELATED [ChEBI]
synonym: "Alkaloid" EXACT [ChEBI]
synonym: "Alkaloide" RELATED [ChEBI]
synonym: "alkaloids" EXACT IUPAC_NAME [IUPAC]
xref: Wikipedia:Alkaloid
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:25212 ! has role metabolite

[Term]
id: CHEBI:22323
name: alkyl group
namespace: chebi_ontology
def: "A univalent group -CnH2n+1 derived from an alkane by removal of a hydrogen atom from any carbon atom." []
subset: 3_STAR
synonym: "alkyl group" EXACT IUPAC_NAME [IUPAC]
synonym: "alkyl groups" EXACT IUPAC_NAME [IUPAC]
synonym: "groupe alkyle" RELATED [IUPAC]
synonym: "grupo alquilo" RELATED [IUPAC]
synonym: "grupos alquilo" RELATED [IUPAC]
is_a: CHEBI:33248 ! hydrocarbyl group
relationship: is_substituent_group_from CHEBI:18310 ! alkane

[Term]
id: CHEBI:22327
name: aliphatic sulfide
namespace: chebi_ontology
subset: 3_STAR
synonym: "aliphatic thioether" RELATED [ChEBI]
synonym: "aliphatic thioethers" RELATED [ChEBI]
is_a: CHEBI:16385 ! organic sulfide

[Term]
id: CHEBI:22333
name: alkylating agent
namespace: chebi_ontology
def: "Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases." []
subset: 3_STAR
is_a: CHEBI:25435 ! mutagen

[Term]
id: CHEBI:22494
name: aminobenzoate
namespace: chebi_ontology
subset: 3_STAR
synonym: "aminobenzoates" RELATED [ChEBI]
is_a: CHEBI:22718 ! benzoates
relationship: is_conjugate_base_of CHEBI:22495 ! aminobenzoic acid

[Term]
id: CHEBI:22495
name: aminobenzoic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "Aminobenzoesaeure" RELATED [ChEBI]
synonym: "aminobenzoic acid" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:22723 ! benzoic acids
is_a: CHEBI:33856 ! aromatic amino acid
relationship: is_conjugate_acid_of CHEBI:22494 ! aminobenzoate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H7NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "137.136" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "137.04768" xsd:string

[Term]
id: CHEBI:22526
name: 4-aminofolic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "4-amino-PGA" RELATED [ChemIDplus]
synonym: "4-aminofolic acid" EXACT [ChemIDplus]
synonym: "4-aminopteroylglutamic acid" RELATED [ChemIDplus]
synonym: "aminopterin" RELATED [ChemIDplus]
synonym: "N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid" RELATED [ChemIDplus]
synonym: "N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:69045 {source="Beilstein"}
xref: CAS:54-62-6 {source="ChemIDplus"}
xref: Drug_Central:21 {source="DrugCentral"}
xref: PMID:18789931 {source="Europe PMC"}
is_a: CHEBI:35692 ! dicarboxylic acid
relationship: has_functional_parent CHEBI:27470 ! folic acid
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:50683 ! has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H20N8O5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TVZGACDUOSZQKY-LBPRGKRZSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "440.41302" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "440.15567" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1" xsd:string

[Term]
id: CHEBI:22527
name: aminopurine
namespace: chebi_ontology
def: "Any purine having at least one amino substituent." []
subset: 3_STAR
synonym: "aminopurines" RELATED [ChEBI]
is_a: CHEBI:26401 ! purines

[Term]
id: CHEBI:22563
name: anion
namespace: chebi_ontology
def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." []
subset: 3_STAR
synonym: "Anion" EXACT [ChEBI]
synonym: "anion" EXACT IUPAC_NAME [IUPAC]
synonym: "anion" EXACT [ChEBI]
synonym: "Anionen" RELATED [ChEBI]
synonym: "aniones" RELATED [ChEBI]
synonym: "anions" RELATED [IUPAC]
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:22586
name: antioxidant
namespace: chebi_ontology
def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." []
subset: 3_STAR
synonym: "antioxidants" RELATED [ChEBI]
synonym: "antioxydant" RELATED [ChEBI]
synonym: "antoxidant" RELATED [ChEBI]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:22587
name: antiviral agent
namespace: chebi_ontology
def: "A substance that destroys or inhibits replication of viruses." []
subset: 3_STAR
synonym: "anti-viral agent" RELATED [ChEBI]
synonym: "anti-viral agents" RELATED [ChEBI]
synonym: "antiviral" RELATED [ChEBI]
synonym: "antiviral agents" RELATED [ChEBI]
synonym: "antivirals" RELATED [ChEBI]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:22681
name: aziridines
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:22695
name: base
namespace: chebi_ontology
def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." []
subset: 3_STAR
synonym: "Base" EXACT [ChEBI]
synonym: "base" EXACT [ChEBI]
synonym: "base" EXACT IUPAC_NAME [IUPAC]
synonym: "Base1" RELATED [KEGG_COMPOUND]
synonym: "Base2" RELATED [KEGG_COMPOUND]
synonym: "Basen" RELATED [ChEBI]
synonym: "bases" RELATED [ChEBI]
synonym: "Nucleobase" RELATED [KEGG_COMPOUND]
xref: KEGG:C00701
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:22712
name: benzenes
namespace: chebi_ontology
def: "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." []
subset: 3_STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound

[Term]
id: CHEBI:22713
name: arenesulfonate oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "arenesulfonates" RELATED [ChEBI]
is_a: CHEBI:33554 ! organosulfonate oxoanion
relationship: is_conjugate_base_of CHEBI:33555 ! arenesulfonic acid

[Term]
id: CHEBI:22718
name: benzoates
namespace: chebi_ontology
def: "A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid." []
subset: 3_STAR
synonym: "benzoate anion" RELATED [ChEBI]
is_a: CHEBI:35757 ! monocarboxylic acid anion
is_a: CHEBI:91007 ! aromatic carboxylate

[Term]
id: CHEBI:22723
name: benzoic acids
namespace: chebi_ontology
def: "Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group." []
subset: 3_STAR
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33859 ! aromatic carboxylic acid

[Term]
id: CHEBI:22727
name: benzopyran
namespace: chebi_ontology
subset: 3_STAR
synonym: "benzopyrans" RELATED [ChEBI]
xref: Wikipedia:Benzopyran
is_a: CHEBI:38104 ! oxacycle
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:22729
name: benzoquinones
namespace: chebi_ontology
def: "Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives." []
subset: 3_STAR
is_a: CHEBI:36141 ! quinone

[Term]
id: CHEBI:22744
name: benzyl group
namespace: chebi_ontology
subset: 3_STAR
synonym: "benzyl" EXACT IUPAC_NAME [IUPAC]
synonym: "Bn" RELATED [ChEBI]
synonym: "C6H5-CH2-" RELATED [IUPAC]
synonym: "phenylalanine side-chain" RELATED [ChEBI]
synonym: "phenylmethyl" RELATED [IUPAC]
is_a: CHEBI:33452 ! benzylic group
is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
relationship: is_substituent_group_from CHEBI:17578 ! toluene
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H7" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "91.13048" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "91.05478" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C=CC=C1)C*" xsd:string

[Term]
id: CHEBI:22908
name: borate
namespace: chebi_ontology
subset: 3_STAR
synonym: "(BO3)3-" RELATED [ChEBI]
synonym: "[BO3](3-)" RELATED [IUPAC]
synonym: "BO3(3-)" RELATED [IUPAC]
synonym: "borate" EXACT IUPAC_NAME [IUPAC]
synonym: "borate ion" RELATED [ChEBI]
synonym: "trioxidoborate(3-)" EXACT IUPAC_NAME [IUPAC]
synonym: "trioxoborate(3-) ion" RELATED [ChEBI]
synonym: "trioxoborate(III) anion" RELATED [ChEBI]
xref: Gmelin:164057 {source="Gmelin"}
is_a: CHEBI:22909 ! borate ion
relationship: is_conjugate_base_of CHEBI:29255 ! hydrogenborate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "BO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/BO3/c2-1(3)4/q-3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BTBUEUYNUDRHOZ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "58.80920" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "58.99569" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]B([O-])[O-]" xsd:string

[Term]
id: CHEBI:22909
name: borate ion
namespace: chebi_ontology
def: "Any inorganic anion that is formally derived from boric acid. The term includes polymeric anions containing chains of BO3 structural units sharing one oxygen atom (e.g. di-, tri-, and tetraborates) as well as chains or rings sharing two oxygen atoms (e.g. metaborates)." []
subset: 3_STAR
synonym: "borate anions" RELATED [ChEBI]
synonym: "borate ion" EXACT [ChEBI]
synonym: "borate ions" RELATED [ChEBI]
xref: Wikipedia:Borate
is_a: CHEBI:24834 ! inorganic anion
is_a: CHEBI:33619 ! boron oxoanion

[Term]
id: CHEBI:22916
name: boron molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "boron compounds" RELATED [ChEBI]
synonym: "boron molecular entities" RELATED [ChEBI]
synonym: "boron molecular entity" EXACT [ChEBI]
is_a: CHEBI:33581 ! boron group molecular entity
relationship: BFO:0000051 CHEBI:27560 ! has part boron atom

[Term]
id: CHEBI:22926
name: bromohydrocarbon
namespace: chebi_ontology
def: "A compound derived from a hydrocarbon by replacing a hydrogen atom with a bromine atom." []
subset: 3_STAR
synonym: "brominated hydrocarbons" RELATED [ChEBI]
synonym: "bromohydrocarbons" RELATED [ChEBI]
is_a: CHEBI:24472 ! halohydrocarbon
is_a: CHEBI:37141 ! organobromine compound

[Term]
id: CHEBI:22927
name: bromine atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "35Br" RELATED [IUPAC]
synonym: "Br" RELATED [ChEBI]
synonym: "Brom" RELATED [ChEBI]
synonym: "brome" RELATED [ChEBI]
synonym: "bromine" EXACT IUPAC_NAME [IUPAC]
synonym: "bromine" RELATED [ChEBI]
synonym: "bromo" RELATED [ChEBI]
synonym: "bromum" RELATED [ChEBI]
xref: WebElements:Br
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24473 ! halogen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Br" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Br" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WKBOTKDWSSQWDR-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "79.90400" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "78.91834" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Br]" xsd:string

[Term]
id: CHEBI:22928
name: bromine molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "bromine compounds" RELATED [ChEBI]
synonym: "bromine molecular entities" RELATED [ChEBI]
synonym: "bromine molecular entity" EXACT [ChEBI]
is_a: CHEBI:24471 ! halogen molecular entity
relationship: BFO:0000051 CHEBI:22927 ! has part bromine atom

[Term]
id: CHEBI:22929
name: bromoalkane
namespace: chebi_ontology
def: "Any haloalkane that consists of an alkane substituted by at least one bromine atom." []
subset: 3_STAR
synonym: "alkyl bromide" RELATED [ChEBI]
synonym: "alkyl bromides" RELATED [ChEBI]
synonym: "bromoalkanes" RELATED [ChEBI]
is_a: CHEBI:24469 ! haloalkane
is_a: CHEBI:37141 ! organobromine compound

[Term]
id: CHEBI:22944
name: butanediols
namespace: chebi_ontology
def: "A diol that is a butanediol or a derivative of a butanediol." []
subset: 3_STAR
is_a: CHEBI:23824 ! diol

[Term]
id: CHEBI:23003
name: carbamate ester
namespace: chebi_ontology
def: "Any ester of carbamic acid or its N-substituted derivatives." []
subset: 3_STAR
synonym: "carbamate esters" RELATED [ChEBI]
synonym: "carbamates" RELATED [ChEBI]
xref: Wikipedia:Carbamate
is_a: CHEBI:33308 ! carboxylic ester
relationship: has_functional_parent CHEBI:28616 ! carbamic acid

[Term]
id: CHEBI:23004
name: carbamoyl group
namespace: chebi_ontology
def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." []
subset: 3_STAR
synonym: "-C(O)NH2" RELATED [ChEBI]
synonym: "-CONH2" RELATED [IUPAC]
synonym: "aminocarbonyl" RELATED [IUPAC]
synonym: "carbamoyl" EXACT IUPAC_NAME [IUPAC]
synonym: "carbamyl" RELATED [ChEBI]
synonym: "carbamyl group" RELATED [ChEBI]
synonym: "carboxamide" RELATED [IUPAC]
xref: PMID:24168430 {source="Europe PMC"}
is_a: CHEBI:27207 ! univalent carboacyl group
relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.03272" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.01364" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(N)=O" xsd:string

[Term]
id: CHEBI:23019
name: carbonyl group
namespace: chebi_ontology
subset: 3_STAR
synonym: ">C=O" RELATED [IUPAC]
synonym: "carbonyl" EXACT IUPAC_NAME [IUPAC]
synonym: "carbonyl group" EXACT [ChEBI]
synonym: "carbonyl group" EXACT [UniProt]
is_a: CHEBI:51422 ! organodiyl group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C(*)*" xsd:string

[Term]
id: CHEBI:23092
name: chemosterilant
namespace: chebi_ontology
def: "A substance intended to sterilize any organism." []
subset: 3_STAR
synonym: "chemosterilants" RELATED [ChEBI]
xref: Wikipedia:Chemosterilant
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:23114
name: chloride salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "chloride salts" RELATED [ChEBI]
synonym: "chlorides" RELATED [ChEBI]
is_a: CHEBI:23117 ! chlorine molecular entity
is_a: CHEBI:33958 ! halide salt
relationship: BFO:0000051 CHEBI:17996 ! has part chloride

[Term]
id: CHEBI:23116
name: chlorine atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "17Cl" RELATED [IUPAC]
synonym: "Chlor" RELATED [ChEBI]
synonym: "chlore" RELATED [ChEBI]
synonym: "chlorine" EXACT IUPAC_NAME [IUPAC]
synonym: "chlorine" RELATED [ChEBI]
synonym: "chlorum" RELATED [ChEBI]
synonym: "Cl" RELATED [IUPAC]
synonym: "cloro" RELATED [ChEBI]
xref: WebElements:Cl
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24473 ! halogen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cl" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZAMOUSCENKQFHK-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "35.45270" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96885" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cl]" xsd:string

[Term]
id: CHEBI:23117
name: chlorine molecular entity
namespace: chebi_ontology
def: "A halogen molecular entity containing one or more atoms of chlorine." []
subset: 3_STAR
is_a: CHEBI:24471 ! halogen molecular entity
relationship: BFO:0000051 CHEBI:23116 ! has part chlorine atom

[Term]
id: CHEBI:23128
name: chloroalkane
namespace: chebi_ontology
def: "Any haloalkane that consists of an alkane substituted by at least one chloro group." []
subset: 3_STAR
synonym: "alkyl chloride" RELATED [ChEBI]
synonym: "alkyl chlorides" RELATED [ChEBI]
synonym: "chloroalkane" EXACT [ChEBI]
synonym: "chloroalkanes" RELATED [ChEBI]
is_a: CHEBI:24469 ! haloalkane
is_a: CHEBI:36683 ! organochlorine compound

[Term]
id: CHEBI:23239
name: chromopeptide
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:25903 ! peptide antibiotic

[Term]
id: CHEBI:23357
name: cofactor
namespace: chebi_ontology
def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." []
subset: 3_STAR
synonym: "cofactor" EXACT [IUPAC]
synonym: "cofactors" EXACT IUPAC_NAME [IUPAC]
xref: Wikipedia:Cofactor_(biochemistry)
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:23359
name: colchicine
namespace: chebi_ontology
def: "An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum." []
subset: 3_STAR
synonym: "N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:2228812 {source="Beilstein"}
xref: CAS:54192-66-4 {source="NIST Chemistry WebBook"}
xref: DrugBank:DB01394
xref: HMDB:HMDB0015466
xref: LINCS:LSM-6449
xref: PMID:10680067 {source="Europe PMC"}
xref: PMID:24074178 {source="Europe PMC"}
xref: PMID:7200520 {source="Europe PMC"}
xref: PMID:9819133 {source="Europe PMC"}
xref: Reaxys:2228812 {source="Reaxys"}
is_a: CHEBI:22160 ! acetamides
is_a: CHEBI:22315 ! alkaloid
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:38032 ! carbotricyclic compound
relationship: RO:0000087 CHEBI:61951 ! has role microtubule-destabilising agent
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H25NO6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IAKHMKGGTNLKSZ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "399.43704" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "399.16819" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1cc2CCC(NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC" xsd:string

[Term]
id: CHEBI:23367
name: molecular entity
namespace: chebi_ontology
def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." []
subset: 3_STAR
synonym: "entidad molecular" RELATED [IUPAC]
synonym: "entidades moleculares" RELATED [IUPAC]
synonym: "entite moleculaire" RELATED [IUPAC]
synonym: "molecular entities" RELATED [IUPAC]
synonym: "molecular entity" EXACT IUPAC_NAME [IUPAC]
synonym: "molekulare Entitaet" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:23377
name: copper molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "copper compounds" RELATED [ChEBI]
synonym: "copper molecular entities" RELATED [ChEBI]
synonym: "copper molecular entity" EXACT [ChEBI]
is_a: CHEBI:33745 ! copper group molecular entity
relationship: BFO:0000051 CHEBI:28694 ! has part copper atom

[Term]
id: CHEBI:23378
name: copper cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "copper cation" EXACT IUPAC_NAME [IUPAC]
synonym: "copper cations" RELATED [ChEBI]
synonym: "Cu cation" RELATED [UniProt]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33515 ! transition element cation
is_a: CHEBI:37404 ! elemental copper
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cu" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "63.546" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.92960" xsd:string

[Term]
id: CHEBI:23414
name: copper(II) sulfate
namespace: chebi_ontology
def: "A metal sulfate compound having copper(2+) as the metal ion." []
subset: 3_STAR
synonym: "copper sulfate" RELATED [ChemIDplus]
synonym: "copper(2+) sulfate" EXACT IUPAC_NAME [IUPAC]
synonym: "Copper(II) sulfate" EXACT [KEGG_COMPOUND]
synonym: "copper(II) sulfate" EXACT IUPAC_NAME [IUPAC]
synonym: "Cupric sulfate" RELATED [ChemIDplus]
synonym: "cupric sulfate anhydrous" RELATED [ChemIDplus]
synonym: "CuSO4" RELATED [IUPAC]
xref: CAS:7758-98-7 {source="ChemIDplus"}
xref: CAS:7758-98-7 {source="KEGG COMPOUND"}
xref: Gmelin:8294 {source="Gmelin"}
xref: KEGG:C18713
xref: PMID:10469300 {source="Europe PMC"}
xref: PMID:29079364 {source="Europe PMC"}
xref: PMID:8566016 {source="Europe PMC"}
xref: PPDB:178
xref: Wikipedia:Copper(II)_sulfate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:51336 ! metal sulfate
relationship: BFO:0000051 CHEBI:29036 ! has part copper(2+)
relationship: RO:0000087 CHEBI:139492 ! has role sensitiser
relationship: RO:0000087 CHEBI:149552 ! has role emetic
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CuO4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cu.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ARUVKPQLZAKDPS-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "159.60960" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "158.88133" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cu++].[O-]S([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:23509
name: cysteine derivative
namespace: chebi_ontology
alt_id: CHEBI:25309
def: "An amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues." []
subset: 3_STAR
synonym: "cysteine derivative" EXACT [ChEBI]
synonym: "cysteine derivatives" RELATED [ChEBI]
is_a: CHEBI:83821 ! amino acid derivative
relationship: has_functional_parent CHEBI:15356 ! cysteine

[Term]
id: CHEBI:23636
name: deoxyribonucleoside
namespace: chebi_ontology
subset: 3_STAR
synonym: "deoxyribonucleosides" RELATED [ChEBI]
is_a: CHEBI:33838 ! nucleoside

[Term]
id: CHEBI:23704
name: diepoxybutane
namespace: chebi_ontology
subset: 3_STAR
synonym: "1,1'-bi[ethylene oxide]" RELATED [NIST_Chemistry_WebBook]
synonym: "1,2:3,4-butadiene diepoxide" RELATED [ChemIDplus]
synonym: "1,2:3,4-dianhydrothreitol" RELATED [NIST_Chemistry_WebBook]
synonym: "1,2:3,4-diepoxybutane" RELATED [ChemIDplus]
synonym: "1,3-butadiene diepoxide" RELATED [NIST_Chemistry_WebBook]
synonym: "2,2'-bioxirane" EXACT IUPAC_NAME [IUPAC]
synonym: "bioxirane" RELATED [NIST_Chemistry_WebBook]
synonym: "Butadiendioxyd" RELATED [ChemIDplus]
synonym: "butadiene diepoxide" RELATED [NIST_Chemistry_WebBook]
synonym: "butadiene dioxide" RELATED [NIST_Chemistry_WebBook]
synonym: "butane diepoxide" RELATED [NIST_Chemistry_WebBook]
synonym: "DEB" RELATED [NIST_Chemistry_WebBook]
synonym: "dioxybutadiene" RELATED [ChemIDplus]
xref: Beilstein:79831 {source="Beilstein"}
xref: CAS:1464-53-5 {source="NIST Chemistry WebBook"}
xref: CAS:1464-53-5 {source="ChemIDplus"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32955 ! epoxide
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H6O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H6O2/c1-3(5-1)4-2-6-4/h3-4H,1-2H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZFIVKAOQEXOYFY-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "86.08924" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "86.03678" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1OC1C1CO1" xsd:string

[Term]
id: CHEBI:23705
name: 1,2:7,8-diepoxyoctane
namespace: chebi_ontology
subset: 3_STAR
synonym: "1,2,7,8-Diepoxyoctane" RELATED [ChemIDplus]
synonym: "1,2-Epoxy-7,8-epoxyoctane" RELATED [ChemIDplus]
synonym: "1,7-Octadiene diepoxide" RELATED [ChemIDplus]
synonym: "2,2'-(1,4-Butanediyl)bisoxirane" RELATED [ChemIDplus]
synonym: "2,2'-butane-1,4-diyldioxirane" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:104873 {source="Beilstein"}
xref: CAS:2426-07-5 {source="ChemIDplus"}
xref: CAS:2426-07-5 {source="NIST Chemistry WebBook"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32955 ! epoxide
relationship: has_parent_hydride CHEBI:17590 ! octane
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H14O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H14O2/c1(3-7-5-9-7)2-4-8-6-10-8/h7-8H,1-6H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LFKLPJRVSHJZPL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "142.19556" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "142.09938" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(CCC1CO1)CC1CO1" xsd:string

[Term]
id: CHEBI:23824
name: diol
namespace: chebi_ontology
def: "A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols." []
subset: 3_STAR
synonym: "diols" EXACT IUPAC_NAME [IUPAC]
xref: Wikipedia:Diol
is_a: CHEBI:26191 ! polyol

[Term]
id: CHEBI:23888
name: drug
namespace: chebi_ontology
def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." []
subset: 3_STAR
synonym: "drugs" RELATED [ChEBI]
synonym: "medicine" RELATED [ChEBI]
is_a: CHEBI:52217 ! pharmaceutical

[Term]
id: CHEBI:23905
name: monoatomic anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:24867 ! monoatomic ion

[Term]
id: CHEBI:23906
name: monoatomic cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic cations" RELATED [ChEBI]
is_a: CHEBI:24867 ! monoatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:23924
name: enzyme inhibitor
namespace: chebi_ontology
def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." []
subset: 3_STAR
synonym: "enzyme inhibitor" EXACT IUPAC_NAME [IUPAC]
synonym: "enzyme inhibitors" RELATED [ChEBI]
synonym: "inhibidor enzimatico" RELATED [ChEBI]
synonym: "inhibidores enzimaticos" RELATED [ChEBI]
synonym: "inhibiteur enzymatique" RELATED [ChEBI]
synonym: "inhibiteurs enzymatiques" RELATED [ChEBI]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:23994
name: ethyl methanesulfonate
namespace: chebi_ontology
def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol." []
subset: 3_STAR
synonym: "EMS" RELATED [ChemIDplus]
synonym: "ethyl mesylate" RELATED [ChemIDplus]
synonym: "ethyl methanesulphonate" RELATED [ChemIDplus]
synonym: "methylsulfonic acid ethyl ester" RELATED [ChemIDplus]
synonym: "methylsulfonic acid, ethyl ester" RELATED [ChemIDplus]
xref: CAS:62-50-0 {source="KEGG COMPOUND"}
xref: CAS:62-50-0 {source="ChemIDplus"}
xref: CAS:62-50-0 {source="NIST Chemistry WebBook"}
xref: KEGG:C19239
xref: PMID:16039156 {source="Europe PMC"}
xref: PMID:19797863 {source="Europe PMC"}
xref: PMID:20102787 {source="Europe PMC"}
xref: PMID:24475756 {source="Europe PMC"}
xref: PMID:24524729 {source="Europe PMC"}
xref: PMID:24531730 {source="Europe PMC"}
xref: PMID:24728647 {source="Europe PMC"}
xref: PMID:6936603 {source="Europe PMC"}
xref: PMID:7285888 {source="Europe PMC"}
xref: Reaxys:773969 {source="Reaxys"}
xref: Wikipedia:Ethyl_methanesulfonate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25223 ! methanesulfonate ester
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:50905 ! has role teratogenic agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H8O3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PLUBXMRUUVWRLT-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "124.15900" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "124.01942" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCOS(C)(=O)=O" xsd:string

[Term]
id: CHEBI:23995
name: N-ethyl-N-nitrosourea
namespace: chebi_ontology
def: "A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups." []
subset: 3_STAR
synonym: "1-(Aminocarbonyl)-1-ethyl-2-oxohydrazine" RELATED [NIST_Chemistry_WebBook]
synonym: "1-Ethyl-1-nitrosourea" RELATED [ChemIDplus]
synonym: "1-ethyl-1-nitrosourea" EXACT IUPAC_NAME [IUPAC]
synonym: "Aethylnitroso-harnstoff" RELATED [ChemIDplus]
synonym: "ENU" RELATED [ChemIDplus]
synonym: "Ethyl nitrosourea" RELATED [ChemIDplus]
synonym: "N-Ethyl-N-nitroso carbamide" RELATED [ChemIDplus]
synonym: "N-Ethyl-N-nitroso-urea" RELATED [ChemIDplus]
synonym: "N-Ethylnitrosourea" RELATED [ChemIDplus]
synonym: "NEU" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1761174 {source="Beilstein"}
xref: CAS:759-73-9 {source="NIST Chemistry WebBook"}
xref: CAS:759-73-9 {source="ChemIDplus"}
xref: CAS:759-73-9 {source="KEGG COMPOUND"}
xref: KEGG:C19178
xref: PMID:11732210 {source="Europe PMC"}
xref: PMID:11853764 {source="Europe PMC"}
xref: PMID:11880538 {source="Europe PMC"}
xref: PMID:16423555 {source="Europe PMC"}
xref: PMID:21861612 {source="Europe PMC"}
xref: PMID:22012195 {source="Europe PMC"}
xref: PMID:22238669 {source="Europe PMC"}
xref: PMID:23551873 {source="Europe PMC"}
xref: PMID:24175309 {source="Europe PMC"}
xref: PMID:8603364 {source="Europe PMC"}
xref: Reaxys:1761174 {source="Reaxys"}
xref: Wikipedia:ENU
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:76551 ! N-nitrosoureas
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7N3O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FUSGACRLAFQQRL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "117.10660" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "117.05383" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(N=O)C(N)=O" xsd:string

[Term]
id: CHEBI:23996
name: ethyl sulfide
namespace: chebi_ontology
def: "An aliphatic sulfide in which the sulfur atom is bonded to at least one ethyl group." []
subset: 3_STAR
synonym: "ethyl sulfides" RELATED [ChEBI]
is_a: CHEBI:22327 ! aliphatic sulfide

[Term]
id: CHEBI:24060
name: fluoride salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "fluoride salts" RELATED [ChEBI]
synonym: "fluorides" RELATED [ChEBI]
is_a: CHEBI:24062 ! fluorine molecular entity
is_a: CHEBI:33958 ! halide salt
relationship: BFO:0000051 CHEBI:17051 ! has part fluoride

[Term]
id: CHEBI:24061
name: fluorine atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "9F" RELATED [IUPAC]
synonym: "F" RELATED [IUPAC]
synonym: "Fluor" RELATED [ChemIDplus]
synonym: "fluor" RELATED [ChEBI]
synonym: "fluorine" EXACT IUPAC_NAME [IUPAC]
synonym: "fluorine" RELATED [ChEBI]
synonym: "fluorum" RELATED [ChEBI]
xref: CAS:7782-41-4 {source="ChemIDplus"}
xref: WebElements:F
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24473 ! halogen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "F" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/F" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YCKRFDGAMUMZLT-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "18.99840" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99840" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[F]" xsd:string

[Term]
id: CHEBI:24062
name: fluorine molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "fluorine compounds" RELATED [ChEBI]
synonym: "fluorine molecular entities" RELATED [ChEBI]
synonym: "fluorine molecular entity" EXACT [ChEBI]
is_a: CHEBI:24471 ! halogen molecular entity
relationship: BFO:0000051 CHEBI:24061 ! has part fluorine atom

[Term]
id: CHEBI:24315
name: glutamic acid derivative
namespace: chebi_ontology
def: "An amino acid derivative resulting from reaction of glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing glutamic acid residues." []
subset: 3_STAR
is_a: CHEBI:83821 ! amino acid derivative
relationship: has_functional_parent CHEBI:18237 ! glutamic acid

[Term]
id: CHEBI:24318
name: glutamine family amino acid
namespace: chebi_ontology
def: "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." []
subset: 3_STAR
synonym: "glutamine family amino acids" RELATED [ChEBI]
xref: PMID:20716061 {source="Europe PMC"}
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83813 ! proteinogenic amino acid

[Term]
id: CHEBI:24319
name: EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
namespace: chebi_ontology
def: "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2)." []
subset: 3_STAR
synonym: "EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors" RELATED [ChEBI]
synonym: "EC 6.3.1.2 inhibitor" RELATED [ChEBI]
synonym: "EC 6.3.1.2 inhibitors" RELATED [ChEBI]
synonym: "glutamate--ammonia ligase (EC 6.3.1.2) inhibitor" RELATED [ChEBI]
synonym: "glutamate--ammonia ligase (EC 6.3.1.2) inhibitors" RELATED [ChEBI]
synonym: "glutamate--ammonia ligase inhibitor" RELATED [ChEBI]
synonym: "glutamate--ammonia ligase inhibitors" RELATED [ChEBI]
synonym: "glutamine synthetase inhibitor" RELATED [ChEBI]
synonym: "glutamine synthetase inhibitors" RELATED [ChEBI]
synonym: "glutamylhydroxamic synthetase inhibitor" RELATED [ChEBI]
synonym: "glutamylhydroxamic synthetase inhibitors" RELATED [ChEBI]
synonym: "L-glutamate:ammonia ligase (ADP-forming) inhibitor" RELATED [ChEBI]
synonym: "L-glutamate:ammonia ligase (ADP-forming) inhibitors" RELATED [ChEBI]
synonym: "L-glutamine synthetase inhibitor" RELATED [ChEBI]
synonym: "L-glutamine synthetase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Glutamine_synthetase
is_a: CHEBI:76823 ! EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor

[Term]
id: CHEBI:24400
name: glycoside
namespace: chebi_ontology
def: "A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively." []
subset: 3_STAR
synonym: "glycosides" EXACT IUPAC_NAME [IUPAC]
synonym: "glycosides" RELATED [ChEBI]
synonym: "O-glycoside" RELATED [ChEBI]
synonym: "O-glycosides" RELATED [ChEBI]
is_a: CHEBI:63161 ! glycosyl compound

[Term]
id: CHEBI:24431
name: chemical entity
namespace: chebi_ontology
def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." []
subset: 3_STAR
synonym: "chemical entity" EXACT [UniProt]

[Term]
id: CHEBI:24432
name: biological role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof within a biological context." []
subset: 3_STAR
synonym: "biological function" RELATED [ChEBI]
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:24433
name: group
namespace: chebi_ontology
def: "A defined linked collection of atoms or a single atom within a molecular entity." []
subset: 3_STAR
synonym: "group" EXACT IUPAC_NAME [IUPAC]
synonym: "groupe" RELATED [IUPAC]
synonym: "grupo" RELATED [IUPAC]
synonym: "grupos" RELATED [IUPAC]
synonym: "Gruppe" RELATED [ChEBI]
synonym: "Rest" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity
relationship: BFO:0000051 CHEBI:33250 ! has part atom

[Term]
id: CHEBI:24436
name: guanidines
namespace: chebi_ontology
def: "Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas." []
subset: 3_STAR
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:24469
name: haloalkane
namespace: chebi_ontology
def: "A halohydrocarbon that is an alkane in which at least one hydrogen atom has been replaced by with a halogen atom." []
subset: 3_STAR
synonym: "alkyl halide" RELATED [ChEBI]
synonym: "alkyl halides" RELATED [ChEBI]
synonym: "haloalkanes" RELATED [ChEBI]
is_a: CHEBI:24472 ! halohydrocarbon

[Term]
id: CHEBI:24471
name: halogen molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "halogen compounds" RELATED [ChEBI]
synonym: "halogen molecular entities" RELATED [ChEBI]
synonym: "halogen molecular entity" EXACT [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:24473 ! has part halogen

[Term]
id: CHEBI:24472
name: halohydrocarbon
namespace: chebi_ontology
def: "A compound derived from a hydrocarbon by replacing a hydrogen atom with a halogen atom." []
subset: 3_STAR
synonym: "halogenated hydrocarbons" RELATED [ChEBI]
synonym: "halohydrocarbons" RELATED [ChEBI]
is_a: CHEBI:17792 ! organohalogen compound
relationship: has_parent_hydride CHEBI:24632 ! hydrocarbon

[Term]
id: CHEBI:24473
name: halogen
namespace: chebi_ontology
subset: 3_STAR
synonym: "group 17 elements" RELATED [ChEBI]
synonym: "group VII elements" RELATED [ChEBI]
synonym: "halogen" EXACT IUPAC_NAME [IUPAC]
synonym: "Halogene" RELATED [ChEBI]
synonym: "halogene" RELATED [ChEBI]
synonym: "halogenes" RELATED [ChEBI]
synonym: "halogeno" RELATED [ChEBI]
synonym: "halogenos" RELATED [ChEBI]
synonym: "halogens" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:24532
name: organic heterocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." []
subset: 3_STAR
synonym: "organic heterocycle" RELATED [ChEBI]
synonym: "organic heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33832 ! organic cyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:24564
name: hexamethylmelamine
namespace: chebi_ontology
subset: 3_STAR
synonym: "2,4,6-tris(dimethylamino)-1,3,5-triazine" RELATED [ChemIDplus]
synonym: "2,4,6-tris(dimethylamino)-s-triazine" RELATED [NIST_Chemistry_WebBook]
synonym: "altretamina" RELATED INN [ChemIDplus]
synonym: "altretamine" RELATED INN [ChemIDplus]
synonym: "altretaminum" RELATED INN [ChemIDplus]
synonym: "Hexalen" RELATED BRAND_NAME [ChemIDplus]
synonym: "Hexastat" RELATED BRAND_NAME [ChemIDplus]
synonym: "HMM" RELATED [ChemIDplus]
synonym: "N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-2,4,6-triamine" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:195058 {source="Beilstein"}
xref: CAS:645-05-6 {source="ChemIDplus"}
xref: CAS:645-05-6 {source="NIST Chemistry WebBook"}
xref: Drug_Central:141 {source="DrugCentral"}
xref: Gmelin:603940 {source="Gmelin"}
xref: LINCS:LSM-3492
xref: Patent:DE1240870
xref: Patent:US3424752
xref: Wikipedia:Altretamine
is_a: CHEBI:38175 ! triamino-1,3,5-triazine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H18N6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UUVWYPNAQBNQJQ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "210.27966" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "210.15929" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)c1nc(nc(n1)N(C)C)N(C)C" xsd:string

[Term]
id: CHEBI:24565
name: hexamethylphosphoric triamide
namespace: chebi_ontology
subset: 3_STAR
synonym: "HEMPA" RELATED [NIST_Chemistry_WebBook]
synonym: "hexamethylorthophosphoric triamide" RELATED [NIST_Chemistry_WebBook]
synonym: "Hexamethylphosphoramid" RELATED [ChEBI]
synonym: "hexamethylphosphoramide" RELATED [ChEBI]
synonym: "hexamethylphosphoric acid triamide" RELATED [ChemIDplus]
synonym: "hexamethylphosphoric triamide" EXACT [ChemIDplus]
synonym: "Hexamethylphosphorsaeuretriamid" RELATED [ChEBI]
synonym: "HMPA" RELATED [ChemIDplus]
synonym: "HMPA" RELATED [KEGG_COMPOUND]
synonym: "HMPT" RELATED [ChemIDplus]
synonym: "HMPTA" RELATED [ChemIDplus]
synonym: "N,N,N',N',N'',N''-hexamethylphosphoric triamide" EXACT IUPAC_NAME [IUPAC]
synonym: "phosphoric acid hexamethyltriamide" RELATED [NIST_Chemistry_WebBook]
synonym: "phosphoric hexamethyltriamide" RELATED [NIST_Chemistry_WebBook]
synonym: "phosphoric tris(dimethylamide)" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1099903 {source="Beilstein"}
xref: CAS:680-31-9 {source="ChemIDplus"}
xref: CAS:680-31-9 {source="NIST Chemistry WebBook"}
xref: CAS:680-31-9 {source="KEGG COMPOUND"}
xref: Gmelin:3259 {source="Gmelin"}
xref: KEGG:C19250
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:17102 ! phosphoramide
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:67105 ! has role insect sterilant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H18N3OP" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GNOIPBMMFNIUFM-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "179.20050" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "179.11875" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)P(=O)(N(C)C)N(C)C" xsd:string

[Term]
id: CHEBI:24624
name: hycanthone mesylate
namespace: chebi_ontology
def: "A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel." []
subset: 3_STAR
synonym: "1-{[2-(diethylamino)ethyl]amino}-4-(hydroxymethyl)-10H-dibenzo[b,e]thiopyran-10-one methanesulfonate" EXACT IUPAC_NAME [IUPAC]
synonym: "Etrenol" RELATED BRAND_NAME [ChEBI]
synonym: "hycanthone methanesulfonate" RELATED [ChemIDplus]
synonym: "hycanthone methanesulphonate" RELATED [ChemIDplus]
synonym: "hycanthone monomesylate" RELATED [ChEBI]
synonym: "hycanthone monomethanesulfonate" RELATED [ChemIDplus]
synonym: "hycanthone monomethanesulphonate" RELATED [ChemIDplus]
synonym: "N,N-diethyl-2-{[4-(hydroxymethyl)-10-oxo-10H-dibenzo[b,e]thiopyran-1-yl]amino}ethanaminium methanesulfonate" RELATED [IUPAC]
synonym: "N-[2-(diethylamino)ethyl]-4-methoxy-9-oxoxanthene-1-amine monomethanesulfonate" RELATED [ChEBI]
xref: CAS:23255-93-8 {source="ChemIDplus"}
xref: CAS:23255-93-8 {source="KEGG COMPOUND"}
xref: KEGG:C19432
xref: PMID:1206768 {source="Europe PMC"}
xref: PMID:1618027 {source="Europe PMC"}
xref: PMID:2266978 {source="Europe PMC"}
xref: PMID:2499511 {source="Europe PMC"}
xref: PMID:2503417 {source="Europe PMC"}
xref: PMID:3104567 {source="Europe PMC"}
xref: PMID:6408464 {source="Europe PMC"}
xref: PMID:6815525 {source="Europe PMC"}
xref: PMID:8375330 {source="Europe PMC"}
xref: Reaxys:4096157 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:38037 ! methanesulfonate salt
relationship: BFO:0000051 CHEBI:67141 ! has part hycanthone(1+)
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:38941 ! has role schistosomicide drug
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H28N2O5S2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H24N2O2S.CH4O3S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20;1-5(2,3)4/h5-10,21,23H,3-4,11-13H2,1-2H3;1H3,(H,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LOEQGPPJCCUXEJ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "452.58700" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "452.14396" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS(O)(=O)=O.CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12" xsd:string

[Term]
id: CHEBI:24632
name: hydrocarbon
namespace: chebi_ontology
def: "A compound consisting of carbon and hydrogen only." []
subset: 3_STAR
synonym: "hidrocarburo" RELATED [IUPAC]
synonym: "hidrocarburos" RELATED [IUPAC]
synonym: "hydrocarbon" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrocarbons" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrocarbure" RELATED [IUPAC]
synonym: "Kohlenwasserstoff" RELATED [ChEBI]
synonym: "Kohlenwasserstoffe" RELATED [ChEBI]
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:24646
name: hydroquinones
namespace: chebi_ontology
alt_id: CHEBI:134188
def: "Benzenediols that have the hydroxy substituents in the 1- and 4-positions." []
subset: 3_STAR
synonym: "1,4-benzoquinols" RELATED [ChEBI]
synonym: "a 1,4-benzoquinol" RELATED [ChEBI]
synonym: "a quinol" RELATED [UniProt]
synonym: "benzene-1,4-diols" RELATED [ChEBI]
is_a: CHEBI:33570 ! benzenediols
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H2O2R4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "106.079" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "106.00548" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC1=C(*)C(*)=C(O)C(*)=C1*" xsd:string

[Term]
id: CHEBI:24651
name: hydroxides
namespace: chebi_ontology
def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." []
subset: 3_STAR
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: BFO:0000051 CHEBI:43176 ! has part hydroxy group

[Term]
id: CHEBI:24697
name: hydroxyflavanone
namespace: chebi_ontology
def: "A member of the class of flavanones that consists of flavanone with one or more hydroxy substituents." []
subset: 3_STAR
synonym: "hydroxyflavanone" EXACT [ChEBI]
synonym: "hydroxyflavanones" RELATED [ChEBI]
is_a: CHEBI:28863 ! flavanones
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:24727
name: hydroxynaphthalene
namespace: chebi_ontology
def: "Any member of the class of  naphthalenes that is naphthalene carrying one or more hydroxy groups." []
subset: 3_STAR
is_a: CHEBI:25477 ! naphthalenes
is_a: CHEBI:33853 ! phenols

[Term]
id: CHEBI:24833
name: oxoacid
namespace: chebi_ontology
def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." []
subset: 3_STAR
synonym: "oxacids" RELATED [ChEBI]
synonym: "oxiacids" RELATED [ChEBI]
synonym: "oxo acid" RELATED [ChEBI]
synonym: "oxoacid" EXACT IUPAC_NAME [IUPAC]
synonym: "oxoacids" EXACT IUPAC_NAME [IUPAC]
synonym: "oxy-acids" RELATED [ChEBI]
synonym: "oxyacids" RELATED [ChEBI]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24651 ! hydroxides
relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid

[Term]
id: CHEBI:24834
name: inorganic anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36914 ! inorganic ion

[Term]
id: CHEBI:24835
name: inorganic molecular entity
namespace: chebi_ontology
def: "A molecular entity that contains no carbon." []
subset: 3_STAR
synonym: "anorganische Verbindungen" RELATED [ChEBI]
synonym: "inorganic compounds" RELATED [ChEBI]
synonym: "inorganic entity" RELATED [ChEBI]
synonym: "inorganic molecular entities" RELATED [ChEBI]
synonym: "inorganics" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:24836
name: inorganic oxide
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic oxides" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25741 ! oxide

[Term]
id: CHEBI:24839
name: inorganic salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "anorganisches Salz" RELATED [ChEBI]
synonym: "inorganic salts" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24866 ! salt

[Term]
id: CHEBI:24840
name: inorganic sulfate salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic sulfate salts" RELATED [ChEBI]
synonym: "inorganic sulfates" RELATED [ChEBI]
is_a: CHEBI:24839 ! inorganic salt
is_a: CHEBI:35175 ! sulfate salt

[Term]
id: CHEBI:24852
name: insecticide
namespace: chebi_ontology
def: "Strictly, a substance intended to kill members of the class Insecta.  In common usage, any substance used for preventing, destroying, repelling or controlling insects." []
subset: 3_STAR
synonym: "insecticides" RELATED [ChEBI]
xref: Wikipedia:Insecticide
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:24853
name: intercalator
namespace: chebi_ontology
def: "A role played by a chemical agent which exhibits the capability of occupying space between DNA base pairs due to particular properties in size, shape and charge. Intercalation of chemical compounds in DNA helix can result in replication errors (shift, mutation) or DNA damages." []
subset: 3_STAR
synonym: "agente intercalante" RELATED [ChEBI]
synonym: "intercalating agent" RELATED [ChEBI]
synonym: "intercalating agents" RELATED [ChEBI]
synonym: "intercalating ligands" RELATED [ChEBI]
synonym: "intercalators" RELATED [ChEBI]
is_a: CHEBI:25435 ! mutagen

[Term]
id: CHEBI:24859
name: iodine atom
namespace: chebi_ontology
def: "Chemical element with atomic number 53." []
subset: 3_STAR
synonym: "53I" RELATED [IUPAC]
synonym: "I" RELATED [ChEBI]
synonym: "Iod" RELATED [ChEBI]
synonym: "iode" RELATED [ChEBI]
synonym: "iodine" EXACT IUPAC_NAME [IUPAC]
synonym: "iodine" RELATED [ChEBI]
synonym: "iodium" RELATED [ChEBI]
synonym: "J" RELATED [ChEBI]
synonym: "Jod" RELATED [ChEBI]
synonym: "yodo" RELATED [ChEBI]
xref: WebElements:I
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24473 ! halogen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "I" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/I" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZCYVEMRRCGMTRW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "126.90447" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "126.90447" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[I]" xsd:string

[Term]
id: CHEBI:24866
name: salt
namespace: chebi_ontology
def: "A salt is an assembly of cations and anions." []
subset: 3_STAR
synonym: "ionic compound" RELATED [ChEBI]
synonym: "ionic compounds" RELATED [ChEBI]
synonym: "sal" RELATED [ChEBI]
synonym: "sales" RELATED [ChEBI]
synonym: "salt" EXACT IUPAC_NAME [IUPAC]
synonym: "salts" RELATED [ChEBI]
synonym: "Salz" RELATED [ChEBI]
synonym: "Salze" RELATED [ChEBI]
synonym: "sel" RELATED [ChEBI]
synonym: "sels" RELATED [ChEBI]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: BFO:0000051 CHEBI:22563 ! has part anion
relationship: BFO:0000051 CHEBI:36916 ! has part cation

[Term]
id: CHEBI:24867
name: monoatomic ion
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:33238 ! monoatomic entity

[Term]
id: CHEBI:24868
name: organic salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic salts" RELATED [ChEBI]
synonym: "organisches Salz" RELATED [ChEBI]
is_a: CHEBI:24866 ! salt

[Term]
id: CHEBI:24870
name: ion
namespace: chebi_ontology
def: "A molecular entity having a net electric charge." []
subset: 3_STAR
synonym: "Ion" EXACT [ChEBI]
synonym: "ion" EXACT IUPAC_NAME [IUPAC]
synonym: "ion" EXACT [ChEBI]
synonym: "Ionen" RELATED [ChEBI]
synonym: "iones" RELATED [ChEBI]
synonym: "ions" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:24921
name: isoquinoline alkaloid
namespace: chebi_ontology
def: "Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine." []
subset: 3_STAR
synonym: "isoquinoline alkaloids" RELATED [ChEBI]
is_a: CHEBI:22315 ! alkaloid

[Term]
id: CHEBI:25212
name: metabolite
namespace: chebi_ontology
alt_id: CHEBI:26619
alt_id: CHEBI:35220
def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." []
subset: 3_STAR
synonym: "metabolite" EXACT IUPAC_NAME [IUPAC]
synonym: "metabolites" RELATED [ChEBI]
synonym: "primary metabolites" RELATED [ChEBI]
synonym: "secondary metabolites" RELATED [ChEBI]
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:25213
name: metal cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "a metal cation" RELATED [UniProt]
synonym: "metal cations" RELATED [ChEBI]
is_a: CHEBI:23906 ! monoatomic cation
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:25223
name: methanesulfonate ester
namespace: chebi_ontology
def: "An organosulfonic ester resulting from the formal condensation of methanesulfonic acid with the hydroxy group of an alcohol, phenol, heteroarenol, or enol." []
subset: 3_STAR
synonym: "mesylate ester" RELATED [ChEBI]
synonym: "mesylate esters" RELATED [ChEBI]
synonym: "methanesulfonic acid esters" RELATED [ChEBI]
is_a: CHEBI:48544 ! methanesulfonates
is_a: CHEBI:83347 ! organosulfonic ester
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3O3SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "95.099" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "94.98029" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS(O*)(=O)=O" xsd:string

[Term]
id: CHEBI:25224
name: methanesulfonate
namespace: chebi_ontology
def: "A 1,1-diunsubstituted alkanesulfonate that is the conjugate base of methanesulfonic acid." []
subset: 3_STAR
synonym: "methanesulfonate" EXACT IUPAC_NAME [IUPAC]
synonym: "methanesulfonate" EXACT [UniProt]
synonym: "methylsulfonate" RELATED [UM-BBD]
xref: MetaCyc:CPD-3746
xref: UM-BBD_compID:c0347 {source="UM-BBD"}
is_a: CHEBI:62081 ! 1,1-diunsubstituted alkanesulfonate
relationship: is_conjugate_base_of CHEBI:27376 ! methanesulfonic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3O3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AFVFQIVMOAPDHO-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "95.09872" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "94.98084" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:25234
name: 1-methoxy-N-nitrosodiethylamine
namespace: chebi_ontology
subset: 3_STAR
synonym: "N-ethyl-1-methoxy-N-nitrosoethanamine" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:4368978 {source="ChemIDplus"}
xref: CAS:61738-03-2 {source="ChemIDplus"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35803 ! nitrosamine
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H12N2O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H12N2O2/c1-4-7(6-8)5(2)9-3/h5H,4H2,1-3H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DCUKVUVLSDGDEZ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "132.16106" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "132.08988" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(N=O)C(C)OC" xsd:string

[Term]
id: CHEBI:25240
name: methoxyflavanone
namespace: chebi_ontology
def: "A member of the class of flavanones that consists of flavanone with one or more methoxy substituents." []
subset: 3_STAR
synonym: "methoxyflavanones" RELATED [ChEBI]
is_a: CHEBI:28863 ! flavanones
is_a: CHEBI:35618 ! aromatic ether

[Term]
id: CHEBI:25255
name: methyl methanesulfonate
namespace: chebi_ontology
def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol." []
subset: 3_STAR
synonym: "as-Dimethyl sulfite" RELATED [ChemIDplus]
synonym: "CB1540" RELATED [ChEBI]
synonym: "Methanesulfonic acid methyl ester" RELATED [ChemIDplus]
synonym: "Methyl mesylate" RELATED [ChemIDplus]
synonym: "methyl methanesulfonate" EXACT IUPAC_NAME [IUPAC]
synonym: "MMS" RELATED [KEGG_COMPOUND]
synonym: "MMS" RELATED [ChemIDplus]
xref: CAS:66-27-3 {source="ChemIDplus"}
xref: CAS:66-27-3 {source="KEGG COMPOUND"}
xref: KEGG:C19181
xref: MetaCyc:CPD-7038
xref: PMID:11016630 {source="Europe PMC"}
xref: PMID:14761437 {source="Europe PMC"}
xref: PMID:16764919 {source="Europe PMC"}
xref: PMID:21353429 {source="Europe PMC"}
xref: PMID:21860482 {source="Europe PMC"}
xref: PMID:22907509 {source="Europe PMC"}
xref: PMID:23117069 {source="Europe PMC"}
xref: PMID:23384783 {source="Europe PMC"}
xref: PMID:23483329 {source="Europe PMC"}
xref: Reaxys:1098586 {source="Reaxys"}
xref: Wikipedia:Methyl_methanesulfonate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25223 ! methanesulfonate ester
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H6O3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MBABOKRGFJTBAE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "110.13200" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "110.00377" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COS(C)(=O)=O" xsd:string

[Term]
id: CHEBI:25348
name: methylxanthine
namespace: chebi_ontology
subset: 3_STAR
synonym: "methylxanthines" RELATED [ChEBI]
is_a: CHEBI:26385 ! purine alkaloid
relationship: has_functional_parent CHEBI:15318 ! xanthine

[Term]
id: CHEBI:25357
name: mitomycin
namespace: chebi_ontology
def: "A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae." []
subset: 3_STAR
synonym: "mitomycins" RELATED [ChEBI]
xref: PMID:19777135 {source="Europe PMC"}
xref: Wikipedia:Mitomycin
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:23003 ! carbamate ester
is_a: CHEBI:25830 ! p-quinones
is_a: CHEBI:38303 ! azirinopyrroloindole
relationship: RO:0000087 CHEBI:24853 ! has role intercalator
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:25367
name: molecule
namespace: chebi_ontology
def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." []
subset: 3_STAR
synonym: "molecula" RELATED [IUPAC]
synonym: "molecule" EXACT [IUPAC]
synonym: "molecules" RELATED [IUPAC]
synonym: "Molekuel" RELATED [ChEBI]
synonym: "neutral molecular compounds" RELATED [IUPAC]
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:25384
name: monocarboxylic acid
namespace: chebi_ontology
def: "An oxoacid containing a single carboxy group." []
subset: 3_STAR
synonym: "monocarboxylic acids" RELATED [ChEBI]
is_a: CHEBI:33575 ! carboxylic acid
relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion

[Term]
id: CHEBI:25392
name: naphthols
namespace: chebi_ontology
def: "Any hydroxynaphthalene derivative that has a single hydroxy substituent." []
subset: 3_STAR
is_a: CHEBI:24727 ! hydroxynaphthalene

[Term]
id: CHEBI:25414
name: monoatomic monocation
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic monocations" RELATED [ChEBI]
synonym: "monovalent inorganic cations" RELATED [ChEBI]
is_a: CHEBI:23906 ! monoatomic cation
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*+]" xsd:string

[Term]
id: CHEBI:25434
name: bis(2-chloroethyl) sulfide
namespace: chebi_ontology
def: "An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention." []
subset: 3_STAR
synonym: "1,1'-thiobis(2-chloroethane)" RELATED [NIST_Chemistry_WebBook]
synonym: "1-chloro-2-[(2-chloroethyl)sulfanyl]ethane" EXACT IUPAC_NAME [IUPAC]
synonym: "1-chloro-2-[(2-chloroethyl)thio]ethane" RELATED [IUPAC]
synonym: "bis(2-chloroethyl) sulfide" EXACT [ChemIDplus]
synonym: "bis(2-chloroethyl) sulphide" RELATED [NIST_Chemistry_WebBook]
synonym: "bis(2-chloroethyl)sulfane" RELATED [IUPAC]
synonym: "Iprit" RELATED [KEGG_COMPOUND]
synonym: "Lost" RELATED [NIST_Chemistry_WebBook]
synonym: "Mustard gas" RELATED [KEGG_COMPOUND]
synonym: "mustard gas" RELATED [ChemIDplus]
synonym: "Senfgas" RELATED [NIST_Chemistry_WebBook]
synonym: "sulfur mustard" RELATED [ChemIDplus]
synonym: "Yperite" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1733595 {source="ChemIDplus"}
xref: CAS:505-60-2 {source="ChemIDplus"}
xref: CAS:505-60-2 {source="KEGG COMPOUND"}
xref: CAS:505-60-2 {source="NIST Chemistry WebBook"}
xref: Gmelin:324535 {source="Gmelin"}
xref: KEGG:C19164
xref: PMID:15908294 {source="Europe PMC"}
xref: PMID:19559099 {source="Europe PMC"}
xref: PMID:23091586 {source="Europe PMC"}
xref: PMID:24467472 {source="Europe PMC"}
xref: PMID:24641121 {source="Europe PMC"}
xref: PMID:24791566 {source="Europe PMC"}
xref: PMID:24801489 {source="Europe PMC"}
xref: Wikipedia:Sulfur_mustard
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:23996 ! ethyl sulfide
is_a: CHEBI:36683 ! organochlorine compound
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:78592 ! has role vesicant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H8Cl2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H8Cl2S/c5-1-3-7-4-2-6/h1-4H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QKSKPIVNLNLAAV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "159.07772" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "157.97238" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "ClCCSCCCl" xsd:string

[Term]
id: CHEBI:25435
name: mutagen
namespace: chebi_ontology
def: "An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution." []
subset: 3_STAR
synonym: "mutagene" RELATED [ChEBI]
synonym: "mutagenes" RELATED [ChEBI]
synonym: "mutagenic agent" RELATED [ChEBI]
synonym: "mutageno" RELATED [ChEBI]
synonym: "mutagenos" RELATED [ChEBI]
synonym: "mutagens" RELATED [ChEBI]
xref: Wikipedia:Mutagen
is_a: CHEBI:50902 ! genotoxin

[Term]
id: CHEBI:25477
name: naphthalenes
namespace: chebi_ontology
def: "Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings." []
subset: 3_STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound
is_a: CHEBI:36785 ! carbobicyclic compound

[Term]
id: CHEBI:25491
name: nematicide
namespace: chebi_ontology
def: "A substance used to destroy pests of the phylum Nematoda (roundworms)." []
subset: 3_STAR
synonym: "nematicides" RELATED [ChEBI]
synonym: "nematocide" RELATED [ChEBI]
synonym: "nematocides" RELATED [ChEBI]
xref: Wikipedia:Nematicide
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:25512
name: neurotransmitter
namespace: chebi_ontology
def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." []
subset: 3_STAR
synonym: "neurotransmitters" RELATED [ChEBI]
xref: Wikipedia:Neurotransmitter
is_a: CHEBI:33280 ! molecular messenger

[Term]
id: CHEBI:25555
name: nitrogen atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "7N" RELATED [IUPAC]
synonym: "azote" RELATED [IUPAC]
synonym: "N" RELATED [IUPAC]
synonym: "nitrogen" EXACT IUPAC_NAME [IUPAC]
synonym: "nitrogen" RELATED [ChEBI]
synonym: "nitrogeno" RELATED [ChEBI]
synonym: "Stickstoff" RELATED [ChEBI]
xref: WebElements:N
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "14.007" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string

[Term]
id: CHEBI:25585
name: nonmetal atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "Nichtmetall" RELATED [ChEBI]
synonym: "Nichtmetalle" RELATED [ChEBI]
synonym: "no metal" RELATED [ChEBI]
synonym: "no metales" RELATED [ChEBI]
synonym: "non-metal" RELATED [ChEBI]
synonym: "non-metaux" RELATED [ChEBI]
synonym: "nonmetal" EXACT IUPAC_NAME [IUPAC]
synonym: "nonmetal" RELATED [ChEBI]
synonym: "nonmetals" RELATED [ChEBI]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:25693
name: organic heteromonocyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic heteromonocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33670 ! heteromonocyclic compound

[Term]
id: CHEBI:25696
name: organic anion
namespace: chebi_ontology
def: "Any organic ion with a net negative charge." []
subset: 3_STAR
synonym: "organic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:25699 ! organic ion

[Term]
id: CHEBI:25697
name: organic cation
namespace: chebi_ontology
def: "Any organic ion with a net positive charge." []
subset: 3_STAR
synonym: "organic cations" RELATED [ChEBI]
is_a: CHEBI:25699 ! organic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:25698
name: ether
namespace: chebi_ontology
def: "An organooxygen compound with formula ROR, where R is not hydrogen." []
subset: 3_STAR
synonym: "ether" EXACT IUPAC_NAME [IUPAC]
synonym: "ethers" EXACT IUPAC_NAME [IUPAC]
synonym: "ethers" RELATED [ChEBI]
is_a: CHEBI:36963 ! organooxygen compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "OR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]O[*]" xsd:string

[Term]
id: CHEBI:25699
name: organic ion
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:25704
name: organic sulfate
namespace: chebi_ontology
def: "Compounds of the general formula SO3HOR where R is an organyl group" []
subset: 3_STAR
synonym: "organic sulfates" RELATED [ChEBI]
is_a: CHEBI:26820 ! sulfates
relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion

[Term]
id: CHEBI:25741
name: oxide
namespace: chebi_ontology
def: "An oxide is a chemical compound of oxygen with other chemical elements." []
subset: 3_STAR
synonym: "oxide" EXACT [ChEBI]
synonym: "oxides" RELATED [ChEBI]
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:25805
name: oxygen atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "8O" RELATED [IUPAC]
synonym: "O" RELATED [IUPAC]
synonym: "oxigeno" RELATED [ChEBI]
synonym: "oxygen" EXACT IUPAC_NAME [IUPAC]
synonym: "oxygen" RELATED [ChEBI]
synonym: "oxygene" RELATED [ChEBI]
synonym: "Sauerstoff" RELATED [ChEBI]
xref: KEGG:C00007
xref: WebElements:O
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QVGXLLKOCUKJST-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O]" xsd:string

[Term]
id: CHEBI:25806
name: oxygen molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxygen molecular entities" RELATED [ChEBI]
synonym: "oxygen molecular entity" EXACT [ChEBI]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: BFO:0000051 CHEBI:25805 ! has part oxygen atom

[Term]
id: CHEBI:25810
name: oxopurine
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxopurines" RELATED [ChEBI]
is_a: CHEBI:26401 ! purines

[Term]
id: CHEBI:25813
name: p-N,N-bis(2-chloroethyl)aminophenylvaleric acid
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:33856 ! aromatic amino acid
is_a: CHEBI:36683 ! organochlorine compound
relationship: has_functional_parent CHEBI:17418 ! valeric acid
relationship: RO:0000087 CHEBI:25435 ! has role mutagen

[Term]
id: CHEBI:25814
name: p-N,N-bis(2-chloroethyl)amino-D-phenylalanine
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:84143 ! D-phenylalanine derivative
relationship: RO:0000087 CHEBI:25435 ! has role mutagen

[Term]
id: CHEBI:25816
name: p-N,N-bis(2-chloroethyl)amino-L-phenylalanine
namespace: chebi_ontology
subset: 1_STAR
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:84144 ! L-phenylalanine derivative
relationship: RO:0000087 CHEBI:25435 ! has role mutagen

[Term]
id: CHEBI:25818
name: 4-(2-aminoethyl)-N,N-bis(2-chloroethyl)aniline
namespace: chebi_ontology
subset: 3_STAR
synonym: "4-(2-aminoethyl)-N,N-bis(2-chloroethyl)aniline" EXACT IUPAC_NAME [IUPAC]
synonym: "4-(bis(2-chloroethyl)amino)benzeneethanamine" RELATED [ChemIDplus]
synonym: "CB 3034" RELATED [ChemIDplus]
synonym: "p-(bis(2-chloroethyl)amino)phenethylamine" RELATED [ChemIDplus]
synonym: "p-N,N-di-(2-chloroethyl)aminophenylethylamine" RELATED [ChemIDplus]
xref: Beilstein:3292665 {source="ChemIDplus"}
xref: CAS:58880-18-5 {source="ChemIDplus"}
is_a: CHEBI:36683 ! organochlorine compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H18Cl2N2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H18Cl2N2/c13-6-9-16(10-7-14)12-3-1-11(2-4-12)5-8-15/h1-4H,5-10,15H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJKCNYLAFQAJDD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "261.19020" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "260.08470" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCc1ccc(cc1)N(CCCl)CCCl" xsd:string

[Term]
id: CHEBI:25829
name: p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine
namespace: chebi_ontology
subset: 1_STAR
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:36683 ! organochlorine compound
relationship: RO:0000087 CHEBI:25435 ! has role mutagen

[Term]
id: CHEBI:25830
name: p-quinones
namespace: chebi_ontology
def: "A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring." []
subset: 3_STAR
synonym: "p-quinone" RELATED [ChEBI]
synonym: "para-quinones" RELATED [ChEBI]
is_a: CHEBI:36141 ! quinone

[Term]
id: CHEBI:25903
name: peptide antibiotic
namespace: chebi_ontology
def: "A chemically diverse class of peptides that exhibit antimicrobial properties." []
subset: 3_STAR
synonym: "peptide antibiotics" RELATED [ChEBI]
xref: MetaCyc:Peptide-Antibiotics
xref: PMID:33398258 {source="Europe PMC"}
is_a: CHEBI:16670 ! peptide
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:25944
name: pesticide
namespace: chebi_ontology
def: "Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests." []
subset: 3_STAR
synonym: "pesticide" EXACT IUPAC_NAME [IUPAC]
synonym: "pesticides" RELATED [ChEBI]
synonym: "Pestizid" RELATED [ChEBI]
synonym: "Pestizide" RELATED [ChEBI]
xref: Wikipedia:Pesticide
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:25985
name: phenylalanine derivative
namespace: chebi_ontology
def: "An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine  by a heteroatom. The definition normally excludes peptides containing phenylalanine  residues." []
subset: 3_STAR
is_a: CHEBI:83821 ! amino acid derivative
relationship: has_functional_parent CHEBI:28044 ! phenylalanine

[Term]
id: CHEBI:26004
name: phenylpropanoid
namespace: chebi_ontology
def: "Any organic aromatic compound with a structure based on a phenylpropane skeleton. The class includes naturally occurring phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules as well as their semi-synthetic and synthetic analogues. Phenylpropanoids are also precursors of lignin." []
subset: 3_STAR
synonym: "phenylpropanoids" RELATED [ChEBI]
xref: Wikipedia:Phenylpropanoid
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:26078
name: phosphoric acid
namespace: chebi_ontology
def: "A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom." []
subset: 3_STAR
synonym: "[PO(OH)3]" RELATED [IUPAC]
synonym: "acide phosphorique" RELATED [ChEBI]
synonym: "acidum phosphoricum" RELATED [ChEBI]
synonym: "H3PO4" RELATED [IUPAC]
synonym: "Orthophosphoric acid" RELATED [KEGG_COMPOUND]
synonym: "orthophosphoric acid" RELATED [NIST_Chemistry_WebBook]
synonym: "Phosphate" RELATED [KEGG_COMPOUND]
synonym: "Phosphoric acid" EXACT [KEGG_COMPOUND]
synonym: "phosphoric acid" EXACT [IUPAC]
synonym: "Phosphorsaeure" RELATED [ChEBI]
synonym: "Phosphorsaeureloesungen" RELATED [ChEBI]
synonym: "tetraoxophosphoric acid" EXACT IUPAC_NAME [IUPAC]
synonym: "trihydrogen tetraoxophosphate(3-)" EXACT IUPAC_NAME [IUPAC]
synonym: "trihydroxidooxidophosphorus" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:1921286 {source="Beilstein"}
xref: CAS:7664-38-2 {source="NIST Chemistry WebBook"}
xref: CAS:7664-38-2 {source="KEGG COMPOUND"}
xref: CAS:7664-38-2 {source="ChemIDplus"}
xref: Drug_Central:4478 {source="DrugCentral"}
xref: Gmelin:2000 {source="Gmelin"}
xref: HMDB:HMDB0002142
xref: KEGG:C00009
xref: KEGG:D05467
xref: KNApSAcK:C00007408
xref: PMID:11455380 {source="Europe PMC"}
xref: PMID:15630224 {source="Europe PMC"}
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:17518491 {source="Europe PMC"}
xref: PMID:22282755 {source="Europe PMC"}
xref: PMID:22333268 {source="Europe PMC"}
xref: PMID:22381614 {source="Europe PMC"}
xref: PMID:22401268 {source="Europe PMC"}
xref: Reaxys:1921286 {source="Reaxys"}
xref: Wikipedia:Phosphoric_Acid
is_a: CHEBI:59698 ! phosphoric acids
relationship: is_conjugate_acid_of CHEBI:39745 ! dihydrogenphosphate
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer
relationship: RO:0000087 CHEBI:46787 ! has role solvent
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H3O4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "97.99520" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "97.97690" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP(=O)(O[H])O[H]" xsd:string

[Term]
id: CHEBI:26082
name: phosphorus molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "phosphorus molecular entities" RELATED [ChEBI]
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: BFO:0000051 CHEBI:28659 ! has part phosphorus atom

[Term]
id: CHEBI:26167
name: polar amino acid
namespace: chebi_ontology
alt_id: CHEBI:8283
def: "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." []
subset: 3_STAR
synonym: "polar amino acid" EXACT [ChEBI]
synonym: "polar amino acids" RELATED [ChEBI]
synonym: "polar amino-acid" RELATED [ChEBI]
synonym: "polar amino-acids" RELATED [ChEBI]
xref: MetaCyc:Polar-amino-acids
xref: PMID:12016058 {source="Europe PMC"}
is_a: CHEBI:33709 ! amino acid
relationship: is_tautomer_of CHEBI:62031 ! polar amino acid zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(C(*)N)=O" xsd:string

[Term]
id: CHEBI:26191
name: polyol
namespace: chebi_ontology
def: "A compound that contains two or more hydroxy groups." []
subset: 3_STAR
synonym: "polyols" RELATED [ChEBI]
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:2634
name: amidine
namespace: chebi_ontology
def: "Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine." []
subset: 3_STAR
synonym: "amidine" EXACT [IUPAC]
synonym: "Amidines" RELATED [KEGG_COMPOUND]
synonym: "amidines" EXACT IUPAC_NAME [IUPAC]
synonym: "amidines" RELATED [ChEBI]
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:26373
name: pteridines
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:26375
name: pterins
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:26373 ! pteridines

[Term]
id: CHEBI:26385
name: purine alkaloid
namespace: chebi_ontology
subset: 3_STAR
synonym: "purine alkaloids" RELATED [ChEBI]
is_a: CHEBI:22315 ! alkaloid
is_a: CHEBI:26401 ! purines

[Term]
id: CHEBI:26386
name: purine nucleobase
namespace: chebi_ontology
def: "A nucleobase whose skeleton is derived from purine." []
subset: 3_STAR
synonym: "a purine nucleobase" RELATED [UniProt]
synonym: "purine bases" RELATED [ChEBI]
synonym: "purine nucleobase" EXACT [ChEBI]
synonym: "purine nucleobases" RELATED [ChEBI]
xref: KEGG:C15587
is_a: CHEBI:18282 ! nucleobase
is_a: CHEBI:26401 ! purines
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H3N4R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "119.104" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "119.03577" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(NC(=NC=2NC=NC12)*)=*" xsd:string

[Term]
id: CHEBI:26401
name: purines
namespace: chebi_ontology
alt_id: CHEBI:13678
def: "A class of imidazopyrimidines that consists of purine and its substituted derivatives." []
subset: 3_STAR
is_a: CHEBI:35875 ! imidazopyrimidine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5N4R7" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "116.080" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.01230" xsd:string

[Term]
id: CHEBI:26432
name: pyrimidine nucleobase
namespace: chebi_ontology
def: "A nucleobase whose skeleton is derived from pyrimidine." []
subset: 3_STAR
synonym: "a pyrimidine nucleobase" RELATED [UniProt]
synonym: "pyrimidine bases" RELATED [ChEBI]
synonym: "pyrimidine nucleobase" EXACT [ChEBI]
synonym: "pyrimidine nucleobases" RELATED [ChEBI]
is_a: CHEBI:18282 ! nucleobase
is_a: CHEBI:39447 ! pyrimidines
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4HN2R4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "77.064" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "77.01397" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N1C(=C(C(=NC1=*)*)*)*" xsd:string

[Term]
id: CHEBI:26440
name: pyrimidine nucleoside
namespace: chebi_ontology
subset: 3_STAR
synonym: "N-D-Ribosylpyrimidine" RELATED [KEGG_COMPOUND]
synonym: "pyrimidine nucleosides" RELATED [ChEBI]
xref: KEGG:C03169
is_a: CHEBI:33838 ! nucleoside
is_a: CHEBI:39447 ! pyrimidines

[Term]
id: CHEBI:26491
name: quinhydrone
namespace: chebi_ontology
subset: 3_STAR
synonym: "Chinhydron" RELATED [ChemIDplus]
synonym: "cyclohexa-2,5-diene-1,4-dione--benzene-1,4-diol (1:1)" EXACT IUPAC_NAME [IUPAC]
synonym: "green hydroquinone" RELATED [NIST_Chemistry_WebBook]
synonym: "p-benzoquinhydrone" RELATED [ChemIDplus]
synonym: "p-benzoquinone--hydroquinone compound (1:1)" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:3919222 {source="Beilstein"}
xref: CAS:106-34-3 {source="ChemIDplus"}
xref: CAS:106-34-3 {source="NIST Chemistry WebBook"}
xref: Gmelin:253527 {source="Gmelin"}
is_a: CHEBI:35504 ! addition compound
relationship: BFO:0000051 CHEBI:16509 ! has part 1,4-benzoquinone
relationship: BFO:0000051 CHEBI:17594 ! has part hydroquinone
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H10O4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H6O2.C6H4O2/c2*7-5-1-2-6(8)4-3-5/h1-4,7-8H;1-4H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDJXVNRFAQSMAA-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "218.20540" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "218.05791" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Oc1ccc(O)cc1.O=C1C=CC(=O)C=C1" xsd:string

[Term]
id: CHEBI:26513
name: quinolines
namespace: chebi_ontology
def: "A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring." []
subset: 3_STAR
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:26548
name: rhamnosylglucoside
namespace: chebi_ontology
subset: 3_STAR
synonym: "rhamnosylglucoside" EXACT [ChEBI]
synonym: "rhamnosylglucosides" RELATED [ChEBI]
is_a: CHEBI:24400 ! glycoside

[Term]
id: CHEBI:26587
name: rutinoside
namespace: chebi_ontology
subset: 3_STAR
synonym: "rutinoside" EXACT [ChEBI]
synonym: "rutinosides" RELATED [ChEBI]
is_a: CHEBI:26548 ! rhamnosylglucoside

[Term]
id: CHEBI:26588
name: 1,3,5-triazines
namespace: chebi_ontology
def: "Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure." []
subset: 3_STAR
synonym: "s-triazines" RELATED [ChEBI]
is_a: CHEBI:38102 ! triazines

[Term]
id: CHEBI:26607
name: saturated fatty acid
namespace: chebi_ontology
def: "Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess." []
subset: 3_STAR
synonym: "saturated fatty acid" EXACT [ChEBI]
synonym: "saturated fatty acids" RELATED [ChEBI]
synonym: "SFA" RELATED [ChEBI]
synonym: "SFAs" RELATED [ChEBI]
xref: PMID:16492686 {source="Europe PMC"}
xref: PMID:19763019 {source="Europe PMC"}
xref: PMID:20237329 {source="Europe PMC"}
is_a: CHEBI:35366 ! fatty acid

[Term]
id: CHEBI:26666
name: short-chain fatty acid
namespace: chebi_ontology
def: "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." []
subset: 3_STAR
synonym: "SCFA" RELATED [ChEBI]
synonym: "SCFAs" RELATED [ChEBI]
synonym: "short-chain fatty acids" RELATED [ChEBI]
xref: PMID:16633129 {source="Europe PMC"}
xref: PMID:16870803 {source="Europe PMC"}
xref: PMID:18203540 {source="Europe PMC"}
xref: PMID:20148677 {source="Europe PMC"}
is_a: CHEBI:35366 ! fatty acid
relationship: is_conjugate_acid_of CHEBI:58951 ! short-chain fatty acid anion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2OR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "45.017" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string

[Term]
id: CHEBI:26708
name: sodium atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "11Na" RELATED [IUPAC]
synonym: "Na" RELATED [IUPAC]
synonym: "Natrium" RELATED [ChemIDplus]
synonym: "natrium" RELATED [IUPAC]
synonym: "sodio" RELATED [ChemIDplus]
synonym: "sodium" EXACT IUPAC_NAME [IUPAC]
synonym: "sodium" RELATED [ChEBI]
xref: CAS:7440-23-5 {source="ChemIDplus"}
xref: Gmelin:16221 {source="Gmelin"}
xref: KEGG:C01330
xref: WebElements:Na
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22314 ! alkali metal atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Na" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Na" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KEAYESYHFKHZAL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "22.98977" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "22.98977" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na]" xsd:string

[Term]
id: CHEBI:26709
name: sodium hydrogensulfite
namespace: chebi_ontology
def: "An inorganic sodium salt having hydrogensulfite as the counterion." []
subset: 3_STAR
synonym: "NaHSO3" RELATED [IUPAC]
synonym: "Natriumbisulfit" RELATED [ChEBI]
synonym: "Natriumhydrogensulfit" RELATED [ChEBI]
synonym: "primaeres Natriumsulfit" RELATED [ChEBI]
synonym: "saures Natriumsulfit" RELATED [ChEBI]
synonym: "sodium bisulfite" RELATED [ChemIDplus]
synonym: "sodium bisulphite" RELATED [ChemIDplus]
synonym: "sodium hydrogen sulfite" RELATED [ChemIDplus]
synonym: "sodium hydrogensulfite" EXACT IUPAC_NAME [IUPAC]
xref: AGR:IND605265115 {source="Europe PMC"}
xref: CAS:7631-90-5 {source="ChemIDplus"}
xref: Gmelin:22395 {source="Gmelin"}
xref: PMID:27905861 {source="Europe PMC"}
xref: PMID:30429859 {source="Europe PMC"}
xref: PMID:32714086 {source="Europe PMC"}
xref: PMID:32785935 {source="Europe PMC"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:38702 ! inorganic sodium salt
is_a: CHEBI:48857 ! sulfite salt
relationship: BFO:0000051 CHEBI:17137 ! has part hydrogensulfite
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:50904 ! has role allergen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HNaO3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Na.H2O3S/c;1-4(2)3/h;(H2,1,2,3)/q+1;/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DWAQJAXMDSEUJJ-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "104.06191" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "103.95441" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na+].OS([O-])=O" xsd:string

[Term]
id: CHEBI:26712
name: sodium molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "sodium compounds" RELATED [ChEBI]
synonym: "sodium molecular entities" RELATED [ChEBI]
is_a: CHEBI:33296 ! alkali metal molecular entity
relationship: BFO:0000051 CHEBI:26708 ! has part sodium atom

[Term]
id: CHEBI:26714
name: sodium salt
namespace: chebi_ontology
def: "Any alkali metal salt having sodium(1+) as the cation." []
subset: 3_STAR
synonym: "Natriumsalz" RELATED [ChEBI]
synonym: "Natriumsalze" RELATED [ChEBI]
synonym: "sodium salts" RELATED [ChEBI]
is_a: CHEBI:26712 ! sodium molecular entity
is_a: CHEBI:35479 ! alkali metal salt
relationship: BFO:0000051 CHEBI:29101 ! has part sodium(1+)

[Term]
id: CHEBI:26800
name: styrylquinoline
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:26513 ! quinolines

[Term]
id: CHEBI:26819
name: sulfuric ester
namespace: chebi_ontology
def: "An ester of an alcohol and sulfuric acid." []
subset: 3_STAR
synonym: "sulfate ester" RELATED [ChEBI]
synonym: "sulfuric acid ester" RELATED [ChEBI]
synonym: "sulfuric acid esters" RELATED [ChEBI]
is_a: CHEBI:35701 ! ester
is_a: CHEBI:37826 ! sulfuric acid derivative
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06300" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]OS(=O)(=O)O[*]" xsd:string

[Term]
id: CHEBI:26820
name: sulfates
namespace: chebi_ontology
def: "Salts and esters of sulfuric acid" []
subset: 3_STAR
synonym: "sulfates" EXACT [ChEBI]
synonym: "sulfuric acid derivative" RELATED [ChEBI]
synonym: "sulphates" RELATED [ChEBI]
is_a: CHEBI:37826 ! sulfuric acid derivative

[Term]
id: CHEBI:26822
name: sulfide
namespace: chebi_ontology
def: "Any sulfur molecular entity that involves either covalently bonded or anionic sulfur." []
subset: 3_STAR
synonym: "sulphides" RELATED [ChEBI]
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:26823
name: sulfites
namespace: chebi_ontology
def: "Any sulfurous acid derivative that is a salt or an ester of sulfurous acid." []
subset: 3_STAR
synonym: "Sulfite" RELATED [ChEBI]
synonym: "sulfito" RELATED [ChEBI]
synonym: "sulfitos" RELATED [ChEBI]
synonym: "sulphites" RELATED [ChEBI]
xref: Wikipedia:Sulfite
is_a: CHEBI:39087 ! sulfurous acid derivative

[Term]
id: CHEBI:26833
name: sulfur atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "16S" RELATED [IUPAC]
synonym: "azufre" RELATED [ChEBI]
synonym: "Elemental sulfur" RELATED [KEGG_COMPOUND]
synonym: "S" RELATED [KEGG_COMPOUND]
synonym: "S" RELATED [IUPAC]
synonym: "Schwefel" RELATED [ChEBI]
synonym: "soufre" RELATED [ChEBI]
synonym: "sulfur" EXACT IUPAC_NAME [IUPAC]
synonym: "sulfur" RELATED [ChEBI]
synonym: "sulfur" RELATED [UniProt]
synonym: "sulphur" RELATED [ChEBI]
synonym: "theion" RELATED [IUPAC]
xref: CAS:7704-34-9 {source="ChemIDplus"}
xref: CAS:7704-34-9 {source="NIST Chemistry WebBook"}
xref: KEGG:C00087
xref: KEGG:D06527
xref: PPDB:605
xref: WebElements:S
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NINIDFKCEFEMDL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "32.06600" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97207" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S]" xsd:string

[Term]
id: CHEBI:26834
name: sulfur-containing amino acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfur-containing amino acids" RELATED [ChEBI]
is_a: CHEBI:33576 ! sulfur-containing carboxylic acid
is_a: CHEBI:33709 ! amino acid
relationship: is_conjugate_acid_of CHEBI:63470 ! sulfur-containing amino-acid anion

[Term]
id: CHEBI:26835
name: sulfur molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfur molecular entities" RELATED [ChEBI]
synonym: "sulfur molecular entity" EXACT [ChEBI]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: BFO:0000051 CHEBI:26833 ! has part sulfur atom

[Term]
id: CHEBI:26836
name: sulfuric acid
namespace: chebi_ontology
def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." []
subset: 3_STAR
synonym: "[S(OH)2O2]" RELATED [MolBase]
synonym: "[SO2(OH)2]" RELATED [IUPAC]
synonym: "Acide sulfurique" RELATED [ChemIDplus]
synonym: "Acido sulfurico" RELATED [ChemIDplus]
synonym: "Acidum sulfuricum" RELATED [ChemIDplus]
synonym: "dihydrogen tetraoxosulfate" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC]
synonym: "H2SO4" RELATED [IUPAC]
synonym: "hydrogen tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogen tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC]
synonym: "Schwefelsaeureloesungen" RELATED [ChemIDplus]
synonym: "Sulfuric acid" EXACT [KEGG_COMPOUND]
synonym: "sulfuric acid" EXACT IUPAC_NAME [IUPAC]
synonym: "sulfuric acid" EXACT [ChEBI]
synonym: "sulphuric acid" RELATED [MolBase]
synonym: "tetraoxosulfuric acid" EXACT IUPAC_NAME [IUPAC]
xref: CAS:7664-93-9 {source="ChemIDplus"}
xref: CAS:7664-93-9 {source="KEGG COMPOUND"}
xref: CAS:7664-93-9 {source="NIST Chemistry WebBook"}
xref: Gmelin:2122 {source="Gmelin"}
xref: KEGG:C00059
xref: KEGG:D05963
xref: KNApSAcK:C00007530
xref: MolBase:4
xref: PMID:13568755 {source="Europe PMC"}
xref: PMID:16122922 {source="Europe PMC"}
xref: PMID:19397353 {source="Europe PMC"}
xref: PMID:22047659 {source="Europe PMC"}
xref: PMID:22136045 {source="Europe PMC"}
xref: PMID:22204399 {source="Europe PMC"}
xref: PMID:22267186 {source="Europe PMC"}
xref: PMID:22296037 {source="Europe PMC"}
xref: PMID:22364556 {source="Europe PMC"}
xref: PMID:22435616 {source="Europe PMC"}
xref: PPDB:606
xref: Reaxys:2037554 {source="Reaxys"}
xref: Wikipedia:Sulfuric_acid
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate
relationship: RO:0000087 CHEBI:35223 ! has role catalyst
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "98.07948" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "97.96738" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OS(=O)(=O)O[H]" xsd:string

[Term]
id: CHEBI:26912
name: oxolanes
namespace: chebi_ontology
def: "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." []
subset: 3_STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:26979
name: organic heterotricyclic compound
namespace: chebi_ontology
def: "An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms." []
subset: 3_STAR
synonym: "heterotricyclic compounds" RELATED [ChEBI]
synonym: "organic heterotricyclic compounds" RELATED [ChEBI]
is_a: CHEBI:36688 ! heterotricyclic compound
is_a: CHEBI:38166 ! organic heteropolycyclic compound
is_a: CHEBI:51959 ! organic tricyclic compound

[Term]
id: CHEBI:27024
name: toluenes
namespace: chebi_ontology
def: "Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group." []
subset: 3_STAR
is_a: CHEBI:22712 ! benzenes

[Term]
id: CHEBI:27027
name: micronutrient
namespace: chebi_ontology
def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." []
subset: 3_STAR
synonym: "micronutrients" RELATED [ChEBI]
synonym: "trace elements" RELATED [ChEBI]
xref: Wikipedia:Micronutrient
is_a: CHEBI:33284 ! nutrient

[Term]
id: CHEBI:27081
name: transition element atom
namespace: chebi_ontology
def: "An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell." []
subset: 3_STAR
synonym: "metal de transicion" RELATED [ChEBI]
synonym: "metal de transition" RELATED [ChEBI]
synonym: "metales de transicion" RELATED [ChEBI]
synonym: "metaux de transition" RELATED [ChEBI]
synonym: "transition element" EXACT IUPAC_NAME [IUPAC]
synonym: "transition element" RELATED [ChEBI]
synonym: "transition elements" RELATED [ChEBI]
synonym: "transition metal" RELATED [ChEBI]
synonym: "transition metals" RELATED [ChEBI]
synonym: "Uebergangselement" RELATED [ChEBI]
synonym: "Uebergangsmetalle" RELATED [ChEBI]
is_a: CHEBI:33521 ! metal atom

[Term]
id: CHEBI:27090
name: triaziquone
namespace: chebi_ontology
def: "A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups." []
subset: 3_STAR
synonym: "1,1',1''-(3,6-Dioxo-1,4-cyclohexadiene-1,2,4-triyl)trisaziridine" RELATED [ChemIDplus]
synonym: "2,3,5-Ethylenimine-1,4-benzoquinone" RELATED [NIST_Chemistry_WebBook]
synonym: "2,3,5-Tri(1-aziridinyl)-p-benzoquinone" RELATED [NIST_Chemistry_WebBook]
synonym: "2,3,5-Tri-(1-aziridinyl)-p-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Triethyleneimino-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Tris(1-aziridino)-p-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Tris(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione" RELATED [NIST_Chemistry_WebBook]
synonym: "2,3,5-Tris(1-aziridinyl)-p-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-tris(aziridin-1-yl)-1,4-benzoquinone" EXACT IUPAC_NAME [IUPAC]
synonym: "2,3,5-Tris(aziridino)-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Tris(ethyleneimino)-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Tris(ethylenimino)-1,4-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Tris(ethylenimino)-p-benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Tris(ethylenimino)benzoquinone" RELATED [ChemIDplus]
synonym: "2,3,5-Trisethyleneiminobenzoquinone" RELATED [ChemIDplus]
synonym: "Triazichon" RELATED [ChemIDplus]
synonym: "triazicuona" RELATED INN [ChemIDplus]
synonym: "triaziquone" RELATED INN [WHO_MedNet]
synonym: "triaziquone" RELATED INN [KEGG_DRUG]
synonym: "Triaziquonum" RELATED INN [ChemIDplus]
synonym: "Triethyleneaminobenzoquinone" RELATED [ChemIDplus]
synonym: "Tris(1-aziridinyl)-p-benzoquinone" RELATED [ChemIDplus]
synonym: "Tris(aziridinyl)-p-benzoquinone" RELATED [NIST_Chemistry_WebBook]
synonym: "Tris(aziridinyl)-para-benzoquinone" RELATED [KEGG_COMPOUND]
synonym: "Tris(ethyleneimino)benzoquinone" RELATED [ChemIDplus]
xref: CAS:68-76-8 {source="ChemIDplus"}
xref: CAS:68-76-8 {source="NIST Chemistry WebBook"}
xref: CAS:68-76-8 {source="KEGG COMPOUND"}
xref: Drug_Central:4372 {source="DrugCentral"}
xref: KEGG:C19542
xref: KEGG:D07254
xref: PMID:146335 {source="Europe PMC"}
xref: PMID:20371239 {source="Europe PMC"}
xref: PMID:362189 {source="Europe PMC"}
xref: PMID:3672382 {source="Europe PMC"}
xref: PMID:582920 {source="Europe PMC"}
xref: PMID:624547 {source="Europe PMC"}
xref: PMID:74416 {source="Europe PMC"}
xref: Reaxys:238057 {source="Reaxys"}
xref: Wikipedia:Triaziquone
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:132124 ! 1,4-benzoquinones
is_a: CHEBI:22681 ! aziridines
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H13N3O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H13N3O2/c16-9-7-8(13-1-2-13)12(17)11(15-5-6-15)10(9)14-3-4-14/h7H,1-6H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PXSOHRWMIRDKMP-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "231.25050" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "231.10078" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1" xsd:string

[Term]
id: CHEBI:27134
name: trimethylxanthine
namespace: chebi_ontology
subset: 3_STAR
synonym: "trimethylxanthines" RELATED [ChEBI]
is_a: CHEBI:25348 ! methylxanthine

[Term]
id: CHEBI:27171
name: organic heterobicyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "heterobicyclic compounds" RELATED [ChEBI]
synonym: "organic heterobicyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33672 ! heterobicyclic compound
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:27207
name: univalent carboacyl group
namespace: chebi_ontology
def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." []
subset: 3_STAR
synonym: "univalent acyl group" RELATED [ChEBI]
synonym: "univalent carboacyl groups" RELATED [ChEBI]
synonym: "univalent carboxylic acyl groups" RELATED [ChEBI]
is_a: CHEBI:37838 ! carboacyl group

[Term]
id: CHEBI:27242
name: uridines
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:39446 ! pyrimidine ribonucleosides
relationship: has_functional_parent CHEBI:17568 ! uracil

[Term]
id: CHEBI:27292
name: vinyl carbamate
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbamic acid, vinyl ester" RELATED [ChemIDplus]
synonym: "ethenyl carbamate" RELATED [ChemIDplus]
synonym: "vinyl carbamate" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:1921122 {source="ChemIDplus"}
xref: CAS:15805-73-9 {source="ChemIDplus"}
is_a: CHEBI:23003 ! carbamate ester
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H5NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H5NO2/c1-2-6-3(4)5/h2H,1H2,(H2,4,5)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LVLANIHJQRZTPY-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "87.07734" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "87.03203" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)OC=C" xsd:string

[Term]
id: CHEBI:27311
name: volatile oil component
namespace: chebi_ontology
def: "Any plant metabolite that is found naturally as a component of a volatile oil." []
subset: 3_STAR
synonym: "essential oil component" RELATED [ChEBI]
synonym: "essential oil components" RELATED [ChEBI]
synonym: "ethereal oil component" RELATED [ChEBI]
synonym: "ethereal oil components" RELATED [ChEBI]
synonym: "volatile oil components" RELATED [ChEBI]
xref: Wikipedia:Essential_oil
is_a: CHEBI:76924 ! plant metabolite

[Term]
id: CHEBI:27314
name: water-soluble vitamin (role)
namespace: chebi_ontology
def: "Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine." []
subset: 3_STAR
synonym: "wasserloesliche Vitamine" RELATED [ChEBI]
synonym: "water-soluble vitamin" RELATED [ChEBI]
synonym: "water-soluble vitamins" RELATED [ChEBI]
is_a: CHEBI:33229 ! vitamin (role)

[Term]
id: CHEBI:27369
name: zwitterion
namespace: chebi_ontology
def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." []
subset: 3_STAR
synonym: "compose zwitterionique" RELATED [IUPAC]
synonym: "compuestos zwitterionicos" RELATED [IUPAC]
synonym: "zwitterion" EXACT IUPAC_NAME [IUPAC]
synonym: "zwitteriones" RELATED [IUPAC]
synonym: "zwitterionic compounds" RELATED [IUPAC]
synonym: "zwitterions" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:51151 ! dipolar compound

[Term]
id: CHEBI:27376
name: methanesulfonic acid
namespace: chebi_ontology
alt_id: CHEBI:6813
def: "An alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl." []
subset: 3_STAR
synonym: "Methanesulfonic acid" EXACT [KEGG_COMPOUND]
synonym: "methanesulfonic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Methansulfonsaeure" RELATED [ChEBI]
synonym: "methylsulfonic acid" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1446024 {source="Beilstein"}
xref: CAS:75-75-2 {source="KEGG COMPOUND"}
xref: CAS:75-75-2 {source="ChemIDplus"}
xref: CAS:75-75-2 {source="NIST Chemistry WebBook"}
xref: Gmelin:1681 {source="Gmelin"}
xref: KEGG:C11145
xref: MetaCyc:CPD-3746
xref: PMID:24304088 {source="Europe PMC"}
xref: PMID:24593036 {source="Europe PMC"}
xref: Reaxys:1446024 {source="Reaxys"}
xref: Wikipedia:Methanesulfonic_acid
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:47901 ! alkanesulfonic acid
is_a: CHEBI:64708 ! one-carbon compound
relationship: is_conjugate_acid_of CHEBI:25224 ! methanesulfonate
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4O3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AFVFQIVMOAPDHO-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.10666" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.98812" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS(O)(=O)=O" xsd:string

[Term]
id: CHEBI:27470
name: folic acid
namespace: chebi_ontology
alt_id: CHEBI:24075
alt_id: CHEBI:42610
alt_id: CHEBI:5140
alt_id: CHEBI:569217
def: "An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation." []
subset: 3_STAR
synonym: "(2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid" RELATED [IUPAC]
synonym: "Acfol" RELATED BRAND_NAME [ChemIDplus]
synonym: "acide folique" RELATED INN [WHO_MedNet]
synonym: "acido folico" RELATED INN [WHO_MedNet]
synonym: "acidum folicum" RELATED INN [WHO_MedNet]
synonym: "Folate" RELATED [KEGG_COMPOUND]
synonym: "folic acid" RELATED INN [WHO_MedNet]
synonym: "Folicet" RELATED BRAND_NAME [KEGG_DRUG]
synonym: "Folsaeure" RELATED [ChEBI]
synonym: "N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid" RELATED [PDBeChem]
synonym: "N-pteroyl-L-glutamic acid" RELATED [ChEBI]
synonym: "PGA" RELATED [NIST_Chemistry_WebBook]
synonym: "PteGlu" RELATED [NIST_Chemistry_WebBook]
synonym: "pteroyl-L-glutamic acid" RELATED [ChemIDplus]
synonym: "pteroyl-L-monoglutamic acid" RELATED [ChemIDplus]
synonym: "pteroylglutamic acid" RELATED [KEGG_COMPOUND]
synonym: "pteroylmonoglutamic acid" RELATED [ChemIDplus]
synonym: "vitamin B11" RELATED [ChemIDplus]
synonym: "vitamin B9" RELATED [ChemIDplus]
synonym: "vitamin Bc" RELATED [ChemIDplus]
synonym: "vitamin Be" RELATED [ChemIDplus]
synonym: "vitamin M" RELATED [ChemIDplus]
xref: AGR:IND606960789 {source="Europe PMC"}
xref: Beilstein:100781 {source="Beilstein"}
xref: CAS:59-30-3 {source="KEGG COMPOUND"}
xref: CAS:59-30-3 {source="NIST Chemistry WebBook"}
xref: CAS:59-30-3 {source="ChemIDplus"}
xref: Chemspider:5815
xref: Drug_Central:1231 {source="DrugCentral"}
xref: DrugBank:DB00158
xref: FooDB:FDB014504
xref: HMDB:HMDB0000121
xref: KEGG:C00504
xref: KEGG:D00070
xref: KNApSAcK:C00001539
xref: LINCS:LSM-5355
xref: MetaCyc:CPD-12826
xref: PDBeChem:FOL
xref: PMID:10138938 {source="Europe PMC"}
xref: PMID:10897644 {source="Europe PMC"}
xref: PMID:10958818 {source="Europe PMC"}
xref: PMID:11261364 {source="Europe PMC"}
xref: PMID:11451208 {source="Europe PMC"}
xref: PMID:11959400 {source="Europe PMC"}
xref: PMID:14387833 {source="Europe PMC"}
xref: PMID:15321809 {source="Europe PMC"}
xref: PMID:15523939 {source="Europe PMC"}
xref: PMID:15754725 {source="Europe PMC"}
xref: PMID:15797531 {source="Europe PMC"}
xref: PMID:15797685 {source="Europe PMC"}
xref: PMID:15831910 {source="Europe PMC"}
xref: PMID:15990733 {source="Europe PMC"}
xref: PMID:16093404 {source="Europe PMC"}
xref: PMID:16277678 {source="Europe PMC"}
xref: PMID:16380297 {source="Europe PMC"}
xref: PMID:16871332 {source="Europe PMC"}
xref: PMID:17784727 {source="Europe PMC"}
xref: PMID:18788725 {source="ChEMBL"}
xref: PMID:19121630 {source="Europe PMC"}
xref: PMID:19335717 {source="Europe PMC"}
xref: PMID:19355913 {source="Europe PMC"}
xref: PMID:24650098 {source="Europe PMC"}
xref: PMID:33624660 {source="Europe PMC"}
xref: PMID:33965562 {source="Europe PMC"}
xref: PMID:33968971 {source="Europe PMC"}
xref: PMID:34207319 {source="Europe PMC"}
xref: PMID:34219855 {source="Europe PMC"}
xref: PMID:7738698 {source="Europe PMC"}
xref: PMID:8235383 {source="Europe PMC"}
xref: PMID:9040515 {source="Europe PMC"}
xref: PMID:9420019 {source="Europe PMC"}
xref: PMID:9565830 {source="Europe PMC"}
xref: PMID:9683174 {source="Europe PMC"}
xref: PMID:9781393 {source="Europe PMC"}
xref: PMID:9808640 {source="Europe PMC"}
xref: PMID:9808641 {source="Europe PMC"}
xref: Reaxys:100781 {source="Reaxys"}
xref: Wikipedia:Folic_Acid
is_a: CHEBI:37445 ! folic acids
is_a: CHEBI:51569 ! N-acyl-amino acid
relationship: has_functional_parent CHEBI:38794 ! pteroic acid
relationship: is_conjugate_acid_of CHEBI:62501 ! folate(2-)
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H19N7O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OVBPIULPVIDEAO-LBPRGKRZSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "441.39750" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "441.13968" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2c(=O)[nH]1" xsd:string

[Term]
id: CHEBI:27504
name: mitomycin C
namespace: chebi_ontology
alt_id: CHEBI:25356
alt_id: CHEBI:6953
subset: 3_STAR
synonym: "7-Amino-9alpha-methoxymitosane" RELATED [ChemIDplus]
synonym: "[(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate" EXACT IUPAC_NAME [IUPAC]
synonym: "Ametycine" RELATED [ChemIDplus]
synonym: "Mitocin-C" RELATED [ChemIDplus]
synonym: "Mitomycin" RELATED [KEGG_COMPOUND]
synonym: "Mitomycin C" EXACT [KEGG_COMPOUND]
synonym: "MMC" RELATED [ChemIDplus]
synonym: "Mutamycin" RELATED [ChemIDplus]
xref: Beilstein:3570056 {source="Beilstein"}
xref: CAS:50-07-7 {source="ChemIDplus"}
xref: CAS:50-07-7 {source="KEGG COMPOUND"}
xref: Drug_Central:1819 {source="DrugCentral"}
xref: DrugBank:DB00305
xref: KEGG:C06681
xref: KEGG:D00208
xref: KNApSAcK:C00018668
xref: LINCS:LSM-6310
xref: PMID:36194168 {source="Europe PMC"}
xref: PMID:36453313 {source="Europe PMC"}
xref: PMID:36473690 {source="Europe PMC"}
xref: Wikipedia:Mitomycin
is_a: CHEBI:25357 ! mitomycin
relationship: is_conjugate_acid_of CHEBI:194095 ! mitomycin C(1-)
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H18N4O5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NWIBSHFKIJFRCO-WUDYKRTCSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "334.32720" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "334.12772" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O" xsd:string

[Term]
id: CHEBI:27560
name: boron atom
namespace: chebi_ontology
alt_id: CHEBI:22915
alt_id: CHEBI:3152
subset: 3_STAR
synonym: "5B" RELATED [IUPAC]
synonym: "B" RELATED [KEGG_COMPOUND]
synonym: "Bor" RELATED [ChEBI]
synonym: "boracium" RELATED [ChEBI]
synonym: "bore" RELATED [ChEBI]
synonym: "boro" RELATED [ChEBI]
synonym: "Boron" RELATED [KEGG_COMPOUND]
synonym: "boron" EXACT IUPAC_NAME [IUPAC]
synonym: "boron" RELATED [ChEBI]
xref: CAS:7440-42-8 {source="ChemIDplus"}
xref: CAS:7440-42-8 {source="KEGG COMPOUND"}
xref: KEGG:C06266
xref: WebElements:B
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:137980 ! metalloid atom
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33317 ! boron group element atom
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "B" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/B" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZOXJGFHDIHLPTG-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "10.81100" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "11.00930" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[B]" xsd:string

[Term]
id: CHEBI:27561
name: oxirane
namespace: chebi_ontology
alt_id: CHEBI:24001
alt_id: CHEBI:4900
def: "A  saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom." []
subset: 3_STAR
synonym: "1,2-Epoxyaethan" RELATED [ChemIDplus]
synonym: "1,2-epoxyethane" RELATED [NIST_Chemistry_WebBook]
synonym: "Aethylenoxid" RELATED [ChemIDplus]
synonym: "Amprolene" RELATED [ChemIDplus]
synonym: "Anprolene" RELATED [NIST_Chemistry_WebBook]
synonym: "Anproline" RELATED [ChemIDplus]
synonym: "Dihydrooxirene" RELATED [ChemIDplus]
synonym: "Dimethylene oxide" RELATED [ChemIDplus]
synonym: "epoxyethane" RELATED [NIST_Chemistry_WebBook]
synonym: "ethene oxide" RELATED [NIST_Chemistry_WebBook]
synonym: "Ethylene oxide" RELATED [KEGG_COMPOUND]
synonym: "ETO" RELATED [ChemIDplus]
synonym: "Oxacyclopropane" RELATED [ChemIDplus]
synonym: "Oxane" RELATED [ChemIDplus]
synonym: "Oxidoethane" RELATED [ChemIDplus]
synonym: "oxirane" EXACT IUPAC_NAME [IUPAC]
synonym: "oxyde d'ethylene" RELATED [ChemIDplus]
synonym: "Oxyfume" RELATED [ChEBI]
xref: Beilstein:102378 {source="Beilstein"}
xref: CAS:75-21-8 {source="NIST Chemistry WebBook"}
xref: CAS:75-21-8 {source="KEGG COMPOUND"}
xref: CAS:75-21-8 {source="ChemIDplus"}
xref: Gmelin:676 {source="Gmelin"}
xref: HMDB:HMDB0031305
xref: KEGG:C06548
xref: KEGG:D03474
xref: PMID:11437638 {source="Europe PMC"}
xref: PMID:24313866 {source="Europe PMC"}
xref: PMID:24882394 {source="Europe PMC"}
xref: PMID:25005741 {source="Europe PMC"}
xref: PMID:3932500 {source="Europe PMC"}
xref: Reaxys:102378 {source="Reaxys"}
xref: UM-BBD_compID:c0527 {source="UM-BBD"}
xref: Wikipedia:Oxirane
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:36389 ! saturated organic heteromonocyclic parent
is_a: CHEBI:38104 ! oxacycle
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4O/c1-2-3-1/h1-2H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IAYPIBMASNFSPL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.05256" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.02621" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1CO1" xsd:string

[Term]
id: CHEBI:27594
name: carbon atom
namespace: chebi_ontology
alt_id: CHEBI:23009
alt_id: CHEBI:3399
subset: 3_STAR
synonym: "6C" RELATED [IUPAC]
synonym: "C" RELATED [KEGG_COMPOUND]
synonym: "C" RELATED [IUPAC]
synonym: "Carbon" RELATED [KEGG_COMPOUND]
synonym: "carbon" EXACT IUPAC_NAME [IUPAC]
synonym: "carbon" RELATED [ChEBI]
synonym: "carbone" RELATED [ChEBI]
synonym: "carbonium" RELATED [ChEBI]
synonym: "carbono" RELATED [ChEBI]
synonym: "Kohlenstoff" RELATED [ChEBI]
xref: CAS:7440-44-0 {source="ChemIDplus"}
xref: CAS:7440-44-0 {source="KEGG COMPOUND"}
xref: KEGG:C06265
xref: WebElements:C
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33306 ! carbon group element atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OKTJSMMVPCPJKN-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "12.01070" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "12.00000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C]" xsd:string

[Term]
id: CHEBI:27666
name: actinomycin D
namespace: chebi_ontology
alt_id: CHEBI:22218
alt_id: CHEBI:2446
subset: 3_STAR
synonym: "2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis-[(18aS)-10c,14,17-trimethyl-5,8,12,15,18-pentaoxo-6c,13t-di(propan-2-yl)-18ar-hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-9c-yl]-3H-phenoxazine-1,9-dicarboxamide" EXACT IUPAC_NAME [IUPAC]
synonym: "2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide" RELATED [ChemIDplus]
synonym: "ActD" RELATED [ChEBI]
synonym: "actinomycin C1" RELATED [ChEBI]
synonym: "Actinomycin D" EXACT [KEGG_COMPOUND]
synonym: "actinomycin IV" RELATED [ChemIDplus]
synonym: "Dactinomycin" RELATED [KEGG_COMPOUND]
xref: Beilstein:4173766 {source="Beilstein"}
xref: CAS:50-76-0 {source="ChemIDplus"}
xref: CAS:50-76-0 {source="KEGG COMPOUND"}
xref: Drug_Central:774 {source="DrugCentral"}
xref: DrugBank:DB00970
xref: KEGG:C06770
xref: KEGG:D00214
xref: LINCS:LSM-5783
xref: Wikipedia:Dactinomycin
is_a: CHEBI:15369 ! actinomycin
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C62H86N12O16" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RJURFGZVJUQBHK-IIXSONLDSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "1255.41700" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1254.62847" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C" xsd:string

[Term]
id: CHEBI:27732
name: caffeine
namespace: chebi_ontology
alt_id: CHEBI:22982
alt_id: CHEBI:3295
alt_id: CHEBI:41472
def: "A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee." []
subset: 3_STAR
synonym: "1,3,7-trimethyl-2,6-dioxopurine" RELATED [ChemIDplus]
synonym: "1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione" EXACT IUPAC_NAME [IUPAC]
synonym: "1,3,7-trimethylpurine-2,6-dione" RELATED [IUPHAR]
synonym: "1,3,7-Trimethylxanthine" RELATED [KEGG_COMPOUND]
synonym: "1,3,7-trimethylxanthine" RELATED [NIST_Chemistry_WebBook]
synonym: "1-methyltheobromine" RELATED [ChemIDplus]
synonym: "3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion" RELATED [NIST_Chemistry_WebBook]
synonym: "7-methyltheophylline" RELATED [NIST_Chemistry_WebBook]
synonym: "anhydrous caffeine" RELATED [KEGG_DRUG]
synonym: "cafeina" RELATED [ChemIDplus]
synonym: "cafeine" RELATED [ChEBI]
synonym: "CAFFEINE" EXACT [PDBeChem]
synonym: "Caffeine" EXACT [KEGG_COMPOUND]
synonym: "caffeine" EXACT [UniProt]
synonym: "Coffein" RELATED [ChemIDplus]
synonym: "guaranine" RELATED [IUPHAR]
synonym: "Koffein" RELATED [ChemIDplus]
synonym: "mateina" RELATED [ChemIDplus]
synonym: "methyltheobromine" RELATED [IUPHAR]
synonym: "teina" RELATED [ChEBI]
synonym: "Thein" RELATED [ChemIDplus]
synonym: "theine" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:17705 {source="Beilstein"}
xref: CAS:58-08-2 {source="NIST Chemistry WebBook"}
xref: CAS:58-08-2 {source="ChemIDplus"}
xref: CAS:58-08-2 {source="KEGG COMPOUND"}
xref: Drug_Central:463 {source="DrugCentral"}
xref: DrugBank:DB00201
xref: Gmelin:103040 {source="Gmelin"}
xref: HMDB:HMDB0001847
xref: KEGG:C07481
xref: KEGG:D00528
xref: KNApSAcK:C00001492
xref: LINCS:LSM-2026
xref: MetaCyc:1-3-7-TRIMETHYLXANTHINE
xref: PDBeChem:CFF
xref: PMID:10510174 {source="Europe PMC"}
xref: PMID:10796597 {source="Europe PMC"}
xref: PMID:10803761 {source="Europe PMC"}
xref: PMID:10822912 {source="Europe PMC"}
xref: PMID:10884512 {source="Europe PMC"}
xref: PMID:10924888 {source="Europe PMC"}
xref: PMID:10983026 {source="Europe PMC"}
xref: PMID:11014293 {source="Europe PMC"}
xref: PMID:11022879 {source="Europe PMC"}
xref: PMID:11209966 {source="Europe PMC"}
xref: PMID:11312039 {source="Europe PMC"}
xref: PMID:11410911 {source="Europe PMC"}
xref: PMID:11431501 {source="Europe PMC"}
xref: PMID:11815511 {source="Europe PMC"}
xref: PMID:11949272 {source="Europe PMC"}
xref: PMID:12397877 {source="Europe PMC"}
xref: PMID:12457274 {source="Europe PMC"}
xref: PMID:12574990 {source="Europe PMC"}
xref: PMID:12915014 {source="Europe PMC"}
xref: PMID:12943586 {source="Europe PMC"}
xref: PMID:14521986 {source="Europe PMC"}
xref: PMID:14607010 {source="Europe PMC"}
xref: PMID:15257305 {source="Europe PMC"}
xref: PMID:15280431 {source="Europe PMC"}
xref: PMID:15681408 {source="Europe PMC"}
xref: PMID:15718055 {source="Europe PMC"}
xref: PMID:15840517 {source="Europe PMC"}
xref: PMID:16143823 {source="Europe PMC"}
xref: PMID:16391865 {source="Europe PMC"}
xref: PMID:16528931 {source="Europe PMC"}
xref: PMID:16644114 {source="Europe PMC"}
xref: PMID:16709440 {source="Europe PMC"}
xref: PMID:16805851 {source="Europe PMC"}
xref: PMID:16856769 {source="Europe PMC"}
xref: PMID:17132260 {source="Europe PMC"}
xref: PMID:17387608 {source="Europe PMC"}
xref: PMID:17508167 {source="Europe PMC"}
xref: PMID:17724925 {source="Europe PMC"}
xref: PMID:17932622 {source="Europe PMC"}
xref: PMID:17957400 {source="Europe PMC"}
xref: PMID:18068204 {source="Europe PMC"}
xref: PMID:18258404 {source="Europe PMC"}
xref: PMID:18421070 {source="Europe PMC"}
xref: PMID:18513215 {source="Europe PMC"}
xref: PMID:18625110 {source="Europe PMC"}
xref: PMID:18647558 {source="Europe PMC"}
xref: PMID:19007524 {source="Europe PMC"}
xref: PMID:19047957 {source="Europe PMC"}
xref: PMID:19084078 {source="Europe PMC"}
xref: PMID:19088793 {source="Europe PMC"}
xref: PMID:19418355 {source="Europe PMC"}
xref: PMID:19879252 {source="Europe PMC"}
xref: PMID:20164568 {source="Europe PMC"}
xref: PMID:20470411 {source="Europe PMC"}
xref: PMID:22114686 {source="Europe PMC"}
xref: PMID:22770225 {source="Europe PMC"}
xref: PMID:23551936 {source="Europe PMC"}
xref: PMID:24039592 {source="Europe PMC"}
xref: PMID:7441110 {source="Europe PMC"}
xref: PMID:7689104 {source="Europe PMC"}
xref: PMID:8332255 {source="Europe PMC"}
xref: PMID:8347173 {source="Europe PMC"}
xref: PMID:8679661 {source="Europe PMC"}
xref: PMID:9063686 {source="Europe PMC"}
xref: PMID:9067318 {source="Europe PMC"}
xref: PMID:9132918 {source="Europe PMC"}
xref: PMID:9218278 {source="Europe PMC"}
xref: Reaxys:17705 {source="Reaxys"}
xref: Wikipedia:Caffeine
is_a: CHEBI:27134 ! trimethylxanthine
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:35337 ! has role central nervous system stimulant
relationship: RO:0000087 CHEBI:35471 ! has role psychotropic drug
relationship: RO:0000087 CHEBI:35498 ! has role diuretic
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:50218 ! has role EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
relationship: RO:0000087 CHEBI:50925 ! has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
relationship: RO:0000087 CHEBI:53121 ! has role adenosine A2A receptor antagonist
relationship: RO:0000087 CHEBI:60809 ! has role adjuvant
relationship: RO:0000087 CHEBI:64047 ! has role food additive
relationship: RO:0000087 CHEBI:67114 ! has role ryanodine receptor agonist
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:85234 ! has role human blood serum metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H10N4O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RYYVLZVUVIJVGH-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "194.19076" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "194.08038" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cn1cnc2n(C)c(=O)n(C)c(=O)c12" xsd:string

[Term]
id: CHEBI:27789
name: 1,2-dichloroethane
namespace: chebi_ontology
alt_id: CHEBI:18881
alt_id: CHEBI:49557
alt_id: CHEBI:497
def: "A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2." []
subset: 3_STAR
synonym: "1,2-DCE" RELATED [NIST_Chemistry_WebBook]
synonym: "1,2-Dichloraethan" RELATED [ChEBI]
synonym: "1,2-DICHLOROETHANE" EXACT [PDBeChem]
synonym: "1,2-Dichloroethane" EXACT [KEGG_COMPOUND]
synonym: "1,2-dichloroethane" EXACT [UniProt]
synonym: "1,2-dichloroethane" EXACT IUPAC_NAME [IUPAC]
synonym: "Aethylenchlorid" RELATED [ChEBI]
synonym: "Aethylendichlorid" RELATED [ChEBI]
synonym: "alpha,beta-dichloroethane" RELATED [NIST_Chemistry_WebBook]
synonym: "DCE" RELATED [ChemIDplus]
synonym: "Dutch liquid" RELATED [KEGG_COMPOUND]
synonym: "EDC" RELATED [ChemIDplus]
synonym: "ethane dichloride" RELATED [ChemIDplus]
synonym: "ethylene chloride" RELATED [ChemIDplus]
synonym: "Ethylene dichloride" RELATED [KEGG_COMPOUND]
synonym: "Glycol dichloride" RELATED [KEGG_COMPOUND]
xref: Beilstein:605264 {source="Beilstein"}
xref: CAS:107-06-2 {source="NIST Chemistry WebBook"}
xref: CAS:107-06-2 {source="ChemIDplus"}
xref: CAS:107-06-2 {source="KEGG COMPOUND"}
xref: DrugBank:DB03733
xref: Gmelin:49272 {source="Gmelin"}
xref: HMDB:HMDB0029571
xref: KEGG:C06752
xref: MetaCyc:12-DICHLOROETHANE
xref: PDBeChem:DCE
xref: PMID:17564600 {source="Europe PMC"}
xref: PMID:18579268 {source="Europe PMC"}
xref: PMID:24228488 {source="Europe PMC"}
xref: PMID:24329990 {source="Europe PMC"}
xref: PMID:24441515 {source="Europe PMC"}
xref: PMID:31520740 {source="Europe PMC"}
xref: PMID:32830330 {source="Europe PMC"}
xref: PMID:33047531 {source="Europe PMC"}
xref: PPDB:2774
xref: Reaxys:605264 {source="Reaxys"}
xref: UM-BBD_compID:c0001 {source="UM-BBD"}
xref: Wikipedia:1\,2-Dichloroethane
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:36016 ! chloroethanes
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent
relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4Cl2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4Cl2/c3-1-2-4/h1-2H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSLDOOZREJYCGB-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "98.95856" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "97.96901" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "ClCCCl" xsd:string

[Term]
id: CHEBI:27899
name: cisplatin
namespace: chebi_ontology
alt_id: CHEBI:23314
alt_id: CHEBI:3722
def: "A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups)." []
subset: 3_STAR
synonym: "(SP-4-2)-diamminedichloridoplatinum" EXACT IUPAC_NAME [IUPAC]
synonym: "(SP-4-2)-diamminedichloroplatinum" EXACT IUPAC_NAME [IUPAC]
synonym: "[PtCl2(NH3)2]" RELATED [KEGG_COMPOUND]
synonym: "Briplatin" RELATED BRAND_NAME [ChemIDplus]
synonym: "CDDP" RELATED [KEGG_COMPOUND]
synonym: "cis-[PtCl2(NH3)2]" RELATED [MolBase]
synonym: "cis-DDP" RELATED [ChemIDplus]
synonym: "cis-diamminedichloridoplatinum(II)" EXACT IUPAC_NAME [IUPAC]
synonym: "cis-diamminedichloroplatinum" RELATED [ChemIDplus]
synonym: "cis-Diamminedichloroplatinum(II)" RELATED [KEGG_COMPOUND]
synonym: "cis-diamminedichloroplatinum(II)" EXACT IUPAC_NAME [IUPAC]
synonym: "cis-diammineplatinum(II) dichloride" RELATED [ChemIDplus]
synonym: "cis-dichlorodiammineplatinum(II)" RELATED [ChemIDplus]
synonym: "cis-platin" RELATED [ChEBI]
synonym: "Cismaplat" RELATED BRAND_NAME [DrugBank]
synonym: "Cisplatin" EXACT [KEGG_COMPOUND]
synonym: "cisplatin" RELATED INN [ChemIDplus]
synonym: "cisplatine" RELATED INN [ChemIDplus]
synonym: "cisplatino" RELATED INN [ChemIDplus]
synonym: "cisplatinum" RELATED INN [ChemIDplus]
synonym: "Lederplatin" RELATED BRAND_NAME [DrugBank]
synonym: "Neoplatin" RELATED BRAND_NAME [DrugBank]
synonym: "Peyrone's chloride" RELATED [ChemIDplus]
synonym: "Peyrone's salt" RELATED [ChEBI]
synonym: "Platamine" RELATED [DrugBank]
synonym: "Platinex" RELATED BRAND_NAME [DrugBank]
synonym: "Platinol" RELATED BRAND_NAME [KEGG_DRUG]
synonym: "Randa" RELATED BRAND_NAME [DrugBank]
xref: CAS:15663-27-1 {source="ChemIDplus"}
xref: CAS:15663-27-1 {source="KEGG COMPOUND"}
xref: DrugBank:DB00515
xref: Gmelin:2519 {source="Gmelin"}
xref: HMDB:HMDB0014656
xref: KEGG:C06911
xref: KEGG:D00275
xref: MetaCyc:CPD0-1392
xref: MolBase:25
xref: Patent:DE2318020
xref: Patent:DE2329485
xref: PMID:10883661 {source="Europe PMC"}
xref: PMID:12537968 {source="Europe PMC"}
xref: PMID:12831510 {source="Europe PMC"}
xref: PMID:12935404 {source="Europe PMC"}
xref: PMID:16327988 {source="Europe PMC"}
xref: PMID:18472761 {source="Europe PMC"}
xref: PMID:1855275 {source="Europe PMC"}
xref: PMID:23554447 {source="Europe PMC"}
xref: PMID:23604226 {source="Europe PMC"}
xref: PMID:23651576 {source="Europe PMC"}
xref: PMID:28494534 {source="Europe PMC"}
xref: Reaxys:11324567 {source="Reaxys"}
xref: Wikipedia:Cisplatin
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:51214 ! diamminedichloroplatinum
relationship: RO:0000087 CHEBI:173085 ! has role ferroptosis inducer
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:47868 ! has role photosensitizing agent
relationship: RO:0000087 CHEBI:50684 ! has role cross-linking reagent
relationship: RO:0000087 CHEBI:61015 ! has role nephrotoxin
relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl2H6N2Pt" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H6Cl2N2Pt" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LXZZYRPGZAFOLE-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "300.04452" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "298.95560" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]" xsd:string

[Term]
id: CHEBI:27919
name: tretamine
namespace: chebi_ontology
alt_id: CHEBI:27109
alt_id: CHEBI:9708
subset: 3_STAR
synonym: "2,4,6-tri(1-aziridinyl)-1,3,5-triazine" RELATED [NIST_Chemistry_WebBook]
synonym: "2,4,6-tri(aziridin-1-yl)-1,3,5-triazine" EXACT IUPAC_NAME [IUPAC]
synonym: "2,4,6-tris(1-aziridinyl)-1,3,5-triazine" RELATED [NIST_Chemistry_WebBook]
synonym: "2,4,6-tris(1-aziridinyl)-s-triazine" RELATED [NIST_Chemistry_WebBook]
synonym: "2,4,6-tris(aziridin-1-yl)-1,3,5-triazine" RELATED [ChEBI]
synonym: "TEM" RELATED [ChEBI]
synonym: "tretamine" EXACT [ChemIDplus]
synonym: "Triethylenemelamine" RELATED [KEGG_COMPOUND]
synonym: "Trisaziridinyltriazine" RELATED [KEGG_COMPOUND]
xref: Beilstein:242245 {source="Beilstein"}
xref: CAS:51-18-3 {source="KEGG COMPOUND"}
xref: CAS:51-18-3 {source="ChemIDplus"}
xref: CAS:51-18-3 {source="NIST Chemistry WebBook"}
xref: Drug_Central:2739 {source="DrugCentral"}
xref: KEGG:C07642
xref: Reaxys:242245 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:26588 ! 1,3,5-triazines
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:67105 ! has role insect sterilant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12N6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IUCJMVBFZDHPDX-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "204.23202" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "204.11234" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1CN1c1nc(nc(n1)N1CC1)N1CC1" xsd:string

[Term]
id: CHEBI:28044
name: phenylalanine
namespace: chebi_ontology
alt_id: CHEBI:25984
alt_id: CHEBI:8089
def: "An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group." []
subset: 3_STAR
synonym: "2-amino-3-phenylpropanoic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "alpha-Amino-beta-phenylpropionic acid" RELATED [KEGG_COMPOUND]
synonym: "DL-Phenylalanine" RELATED [KEGG_COMPOUND]
synonym: "F" RELATED [ChEBI]
synonym: "fenilalanina" RELATED [ChEBI]
synonym: "PHE" RELATED [ChEBI]
synonym: "Phenylalanin" RELATED [ChEBI]
synonym: "Phenylalanine" EXACT [KEGG_COMPOUND]
synonym: "phenylalanine" EXACT [ChEBI]
synonym: "phenylalanine" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:1910407 {source="Beilstein"}
xref: CAS:150-30-1 {source="ChemIDplus"}
xref: CAS:150-30-1 {source="NIST Chemistry WebBook"}
xref: Gmelin:50836 {source="Gmelin"}
xref: KEGG:C02057
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:22264337 {source="Europe PMC"}
xref: Reaxys:1910407 {source="Reaxys"}
xref: Wikipedia:Phenylalanine
is_a: CHEBI:33704 ! alpha-amino acid
is_a: CHEBI:33856 ! aromatic amino acid
relationship: BFO:0000051 CHEBI:22744 ! has part benzyl group
relationship: is_conjugate_acid_of CHEBI:32504 ! phenylalaninate
relationship: is_conjugate_base_of CHEBI:32505 ! phenylalaninium
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18918" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(Cc1ccccc1)C(O)=O" xsd:string

[Term]
id: CHEBI:28230
name: hesperetin
namespace: chebi_ontology
alt_id: CHEBI:24529
alt_id: CHEBI:5681
def: "A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position." []
subset: 3_STAR
synonym: "(-)-(S)-hesperetin" RELATED [ChEBI]
synonym: "(-)-hesperetin" RELATED [ChEBI]
synonym: "(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one" EXACT IUPAC_NAME [IUPAC]
synonym: "(2S)-hesperetin" RELATED [UniProt]
synonym: "(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one" RELATED [ChEBI]
synonym: "3',5,7-Trihydroxy-4'-methoxyflavanone" RELATED [KEGG_COMPOUND]
synonym: "Hesperetin" EXACT [KEGG_COMPOUND]
xref: Beilstein:92705 {source="Beilstein"}
xref: CAS:520-33-2 {source="ChemIDplus"}
xref: CAS:520-33-2 {source="KEGG COMPOUND"}
xref: Drug_Central:1362 {source="DrugCentral"}
xref: DrugBank:DB01094
xref: HMDB:HMDB0005782
xref: KEGG:C01709
xref: KNApSAcK:C00000968
xref: LINCS:LSM-20933
xref: LIPID_MAPS_instance:LMPK12140003 {source="LIPID MAPS"}
xref: MetaCyc:CPD-7072
xref: PMID:16964766 {source="Europe PMC"}
xref: PMID:22409373 {source="Europe PMC"}
xref: PMID:22794525 {source="Europe PMC"}
xref: PMID:22899565 {source="Europe PMC"}
xref: PMID:22903244 {source="Europe PMC"}
xref: Reaxys:92705 {source="Reaxys"}
xref: Wikipedia:Hesperetin
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:140332 ! 4'-methoxyflavanones
is_a: CHEBI:38738 ! monomethoxyflavanone
is_a: CHEBI:38739 ! trihydroxyflavanone
is_a: CHEBI:48024 ! 3'-hydroxyflavanones
relationship: is_conjugate_acid_of CHEBI:61249 ! hesperetin(1-)
relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H14O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AIONOLUJZLIMTK-AWEZNQCLSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "302.27880" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "302.07904" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1" xsd:string

[Term]
id: CHEBI:28262
name: dimethyl sulfoxide
namespace: chebi_ontology
alt_id: CHEBI:23801
alt_id: CHEBI:42138
alt_id: CHEBI:4612
def: "A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents." []
subset: 3_STAR
synonym: "(CH3)2SO" RELATED [NIST_Chemistry_WebBook]
synonym: "(methanesulfinyl)methane" EXACT IUPAC_NAME [IUPAC]
synonym: "DIMETHYL SULFOXIDE" EXACT [PDBeChem]
synonym: "Dimethyl sulfoxide" EXACT [KEGG_COMPOUND]
synonym: "dimethyl sulfoxide" EXACT [UniProt]
synonym: "dimethyl sulfoxide" EXACT IUPAC_NAME [IUPAC]
synonym: "dimethyl sulfoxide" RELATED INN [ChemIDplus]
synonym: "dimethyl sulfur oxide" RELATED [NIST_Chemistry_WebBook]
synonym: "dimethyl sulphoxide" RELATED [ChemIDplus]
synonym: "dimethyli sulfoxidum" RELATED INN [ChemIDplus]
synonym: "Dimethylsulfoxid" RELATED [ChEBI]
synonym: "dimethylsulfoxyde" RELATED INN [ChemIDplus]
synonym: "dimetil sulfoxido" RELATED INN [ChemIDplus]
synonym: "DMSO" RELATED [KEGG_COMPOUND]
synonym: "dmso" RELATED [IUPAC]
synonym: "methylsulfinylmethane" RELATED [ChemIDplus]
synonym: "S(O)Me2" RELATED [ChEBI]
synonym: "sulfinylbis(methane)" RELATED [ChemIDplus]
xref: Beilstein:506008 {source="Beilstein"}
xref: CAS:67-68-5 {source="NIST Chemistry WebBook"}
xref: CAS:67-68-5 {source="ChemIDplus"}
xref: CAS:67-68-5 {source="KEGG COMPOUND"}
xref: Chemspider:659
xref: Drug_Central:906 {source="DrugCentral"}
xref: DrugBank:DB01093
xref: FooDB:FDB000764
xref: Gmelin:1556 {source="Gmelin"}
xref: HMDB:HMDB0002151
xref: KEGG:C11143
xref: KEGG:D01043
xref: KNApSAcK:C00053120
xref: LINCS:LSM-36361
xref: MetaCyc:DMSO
xref: PDBeChem:DMS
xref: PMID:10298633 {source="Europe PMC"}
xref: PMID:11162043 {source="Europe PMC"}
xref: PMID:11350866 {source="Europe PMC"}
xref: PMID:11474739 {source="Europe PMC"}
xref: PMID:12663039 {source="Europe PMC"}
xref: PMID:15237653 {source="Europe PMC"}
xref: PMID:15588915 {source="Europe PMC"}
xref: PMID:15868171 {source="Europe PMC"}
xref: PMID:16434015 {source="Europe PMC"}
xref: PMID:16522014 {source="Europe PMC"}
xref: PMID:19096138 {source="Europe PMC"}
xref: PMID:19382398 {source="Europe PMC"}
xref: PMID:19443933 {source="Europe PMC"}
xref: PMID:20828537 {source="Europe PMC"}
xref: PMID:21426213 {source="Europe PMC"}
xref: PMID:22030943 {source="Europe PMC"}
xref: PMID:22722716 {source="Europe PMC"}
xref: PMID:22768202 {source="Europe PMC"}
xref: PMID:22814967 {source="Europe PMC"}
xref: PMID:23050031 {source="Europe PMC"}
xref: PMID:23313473 {source="Europe PMC"}
xref: PMID:28220525 {source="Europe PMC"}
xref: PMID:29938311 {source="Europe PMC"}
xref: PMID:31489176 {source="Europe PMC"}
xref: PMID:3510103 {source="Europe PMC"}
xref: PMID:3898376 {source="Europe PMC"}
xref: PMID:3916302 {source="Europe PMC"}
xref: PMID:4223708 {source="Europe PMC"}
xref: PMID:4556944 {source="Europe PMC"}
xref: PMID:4963226 {source="Europe PMC"}
xref: PMID:6309056 {source="Europe PMC"}
xref: PMID:6379027 {source="Europe PMC"}
xref: Reaxys:506008 {source="Reaxys"}
xref: UM-BBD_compID:c0236 {source="UM-BBD"}
xref: Wikipedia:Dimethyl_sulfoxide
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:22063 ! sulfoxide
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:35481 ! has role non-narcotic analgesic
relationship: RO:0000087 CHEBI:37335 ! has role MRI contrast agent
relationship: RO:0000087 CHEBI:48358 ! has role polar aprotic solvent
relationship: RO:0000087 CHEBI:48578 ! has role radical scavenger
relationship: RO:0000087 CHEBI:50247 ! has role antidote
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H6OS" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H6OS/c1-4(2)3/h1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IAZDPXIOMUYVGZ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "78.13444" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "78.01394" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS(C)=O" xsd:string

[Term]
id: CHEBI:28534
name: 1,2-dibromoethane
namespace: chebi_ontology
alt_id: CHEBI:18880
alt_id: CHEBI:496
def: "A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae." []
subset: 3_STAR
synonym: "1,2-Dibromoethane" EXACT [KEGG_COMPOUND]
synonym: "1,2-dibromoethane" EXACT [UniProt]
synonym: "1,2-dibromoethane" EXACT IUPAC_NAME [IUPAC]
synonym: "alpha,beta-dibromoethane" RELATED [NIST_Chemistry_WebBook]
synonym: "alpha,omega-dibromoethane" RELATED [ChemIDplus]
synonym: "DBE" RELATED [NIST_Chemistry_WebBook]
synonym: "EDB" RELATED [NIST_Chemistry_WebBook]
synonym: "ethylene bromide" RELATED [NIST_Chemistry_WebBook]
synonym: "Ethylene dibromide" RELATED [KEGG_COMPOUND]
synonym: "sym-Dibromoethane" RELATED [ChemIDplus]
xref: Beilstein:605266 {source="Beilstein"}
xref: CAS:106-93-4 {source="NIST Chemistry WebBook"}
xref: CAS:106-93-4 {source="ChemIDplus"}
xref: CAS:106-93-4 {source="KEGG COMPOUND"}
xref: Gmelin:1913 {source="Gmelin"}
xref: HMDB:HMDB0060334
xref: KEGG:C11088
xref: MetaCyc:12-DIBROMOETHANE
xref: PMID:10088182 {source="Europe PMC"}
xref: PMID:11312844 {source="Europe PMC"}
xref: PPDB:1484
xref: Reaxys:605266 {source="Reaxys"}
xref: Wikipedia:1\,2-Dibromoethane
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22926 ! bromohydrocarbon
is_a: CHEBI:22929 ! bromoalkane
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:39276 ! has role fumigant
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76507 ! has role marine metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4Br2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4Br2/c3-1-2-4/h1-2H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PAAZPARNPHGIKF-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "187.86116" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "185.86798" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "BrCCBr" xsd:string

[Term]
id: CHEBI:28616
name: carbamic acid
namespace: chebi_ontology
alt_id: CHEBI:22504
alt_id: CHEBI:23002
alt_id: CHEBI:3386
alt_id: CHEBI:44573
def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." []
subset: 3_STAR
synonym: "Aminoameisensaeure" RELATED [ChEBI]
synonym: "Aminoformic acid" RELATED [KEGG_COMPOUND]
synonym: "Carbamate" RELATED [KEGG_COMPOUND]
synonym: "CARBAMIC ACID" EXACT [PDBeChem]
synonym: "Carbamic acid" EXACT [KEGG_COMPOUND]
synonym: "carbamic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Carbamidsaeure" RELATED [ChEBI]
xref: Beilstein:1734754 {source="Beilstein"}
xref: CAS:463-77-4 {source="KEGG COMPOUND"}
xref: CAS:463-77-4 {source="ChemIDplus"}
xref: DrugBank:DB04261
xref: Gmelin:130345 {source="Gmelin"}
xref: KEGG:C01563
xref: PDBeChem:OUT
xref: Wikipedia:Carbamic_acid
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:64708 ! one-carbon compound
relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "61.04006" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "61.01638" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(O)=O" xsd:string

[Term]
id: CHEBI:28659
name: phosphorus atom
namespace: chebi_ontology
alt_id: CHEBI:26080
alt_id: CHEBI:8168
subset: 3_STAR
synonym: "15P" RELATED [IUPAC]
synonym: "fosforo" RELATED [ChEBI]
synonym: "P" RELATED [IUPAC]
synonym: "P" RELATED [KEGG_COMPOUND]
synonym: "Phosphor" RELATED [ChEBI]
synonym: "phosphore" RELATED [ChEBI]
synonym: "Phosphorus" RELATED [KEGG_COMPOUND]
synonym: "phosphorus" EXACT IUPAC_NAME [IUPAC]
synonym: "phosphorus" RELATED [ChEBI]
xref: CAS:7723-14-0 {source="ChemIDplus"}
xref: CAS:7723-14-0 {source="KEGG COMPOUND"}
xref: Gmelin:16235 {source="Gmelin"}
xref: KEGG:C06262
xref: WebElements:P
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OAICVXFJPJFONN-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "30.97376" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.97376" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[P]" xsd:string

[Term]
id: CHEBI:28694
name: copper atom
namespace: chebi_ontology
alt_id: CHEBI:23376
alt_id: CHEBI:3874
subset: 3_STAR
synonym: "29Cu" RELATED [IUPAC]
synonym: "cobre" RELATED [ChEBI]
synonym: "Copper" RELATED [KEGG_COMPOUND]
synonym: "copper" EXACT IUPAC_NAME [IUPAC]
synonym: "copper" RELATED [ChEBI]
synonym: "Cu" RELATED [ChEBI]
synonym: "Cu" RELATED [IUPAC]
synonym: "cuivre" RELATED [ChEBI]
synonym: "cuprum" RELATED [IUPAC]
synonym: "Kupfer" RELATED [ChEBI]
xref: CAS:7440-50-8 {source="ChemIDplus"}
xref: CAS:7440-50-8 {source="KEGG COMPOUND"}
xref: Gmelin:16269 {source="Gmelin"}
xref: KEGG:C00070
xref: WebElements:Cu
is_a: CHEBI:33366 ! copper group element atom
is_a: CHEBI:88184 ! metal allergen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cu" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cu" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RYGMFSIKBFXOCR-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "63.54600" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.92960" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cu]" xsd:string

[Term]
id: CHEBI:28741
name: sodium fluoride
namespace: chebi_ontology
alt_id: CHEBI:26713
alt_id: CHEBI:9178
def: "A metal fluoride salt with a Na(+) counterion." []
subset: 3_STAR
synonym: "NaF" RELATED [IUPAC]
synonym: "Sodium fluoride" EXACT [KEGG_COMPOUND]
synonym: "sodium fluoride" EXACT IUPAC_NAME [IUPAC]
xref: CAS:7681-49-4 {source="KEGG COMPOUND"}
xref: CAS:7681-49-4 {source="ChemIDplus"}
xref: KEGG:C08142
xref: KEGG:D00943
xref: Wikipedia:Sodium_Fluoride
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24060 ! fluoride salt
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "FNa" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Na.F" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/FH.Na/h1H;/q;+1/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PUZPDOWCWNUUKD-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "41.98817" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.98817" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[F-].[Na+]" xsd:string

[Term]
id: CHEBI:28775
name: hesperidin
namespace: chebi_ontology
alt_id: CHEBI:24530
alt_id: CHEBI:5682
def: "A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage." []
subset: 3_STAR
synonym: "(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC]
synonym: "(2S)-hesperidin" RELATED [UniProt]
synonym: "(S)-(-)-hesperidin" RELATED [ChemIDplus]
synonym: "Cirantin" RELATED [ChemIDplus]
synonym: "Ciratin" RELATED [KEGG_COMPOUND]
synonym: "Hesperetin 7-O-rutinoside" RELATED [KEGG_COMPOUND]
synonym: "Hesperidin" EXACT [KEGG_COMPOUND]
synonym: "Hesperidoside" RELATED [ChemIDplus]
xref: Beilstein:75140 {source="Beilstein"}
xref: CAS:520-26-3 {source="KEGG COMPOUND"}
xref: CAS:520-26-3 {source="ChemIDplus"}
xref: DrugBank:DB04703
xref: HMDB:HMDB0003265
xref: KEGG:C09755
xref: KEGG:D01038
xref: KNApSAcK:C00000970
xref: LINCS:LSM-2858
xref: MetaCyc:CPD-7075
xref: Reaxys:75140 {source="Reaxys"}
xref: Wikipedia:Hesperidin
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:140332 ! 4'-methoxyflavanones
is_a: CHEBI:26587 ! rutinoside
is_a: CHEBI:38738 ! monomethoxyflavanone
is_a: CHEBI:38749 ! dihydroxyflavanone
is_a: CHEBI:48024 ! 3'-hydroxyflavanones
is_a: CHEBI:63353 ! disaccharide derivative
is_a: CHEBI:72730 ! flavanone glycoside
relationship: has_functional_parent CHEBI:28230 ! hesperetin
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C28H34O15" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QUQPHWDTPGMPEX-QJBIFVCTSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "610.56056" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "610.18977" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1" xsd:string

[Term]
id: CHEBI:28830
name: chlorambucil
namespace: chebi_ontology
alt_id: CHEBI:25817
alt_id: CHEBI:3601
alt_id: CHEBI:48770
def: "A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia." []
subset: 3_STAR
synonym: "4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid" RELATED [NIST_Chemistry_WebBook]
synonym: "4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid" RELATED [NIST_Chemistry_WebBook]
synonym: "4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Ambochlorin" RELATED [NIST_Chemistry_WebBook]
synonym: "CHLORAMBUCIL" EXACT [PDBeChem]
synonym: "Chlorambucil" EXACT [KEGG_DRUG]
synonym: "chloraminophen" RELATED [ChemIDplus]
synonym: "gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid" RELATED [NIST_Chemistry_WebBook]
synonym: "Leukeran" RELATED [NIST_Chemistry_WebBook]
synonym: "N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid" RELATED [NIST_Chemistry_WebBook]
synonym: "phenylbutyric acid nitrogen mustard" RELATED [ChemIDplus]
xref: Beilstein:999011 {source="Beilstein"}
xref: CAS:305-03-3 {source="ChemIDplus"}
xref: CAS:305-03-3 {source="NIST Chemistry WebBook"}
xref: Drug_Central:588 {source="DrugCentral"}
xref: DrugBank:DB00291
xref: KEGG:D00266
xref: LINCS:LSM-2645
xref: PDBeChem:CBL
xref: PMID:22025197 {source="Europe PMC"}
xref: PMID:22978684 {source="Europe PMC"}
xref: PMID:23233721 {source="Europe PMC"}
xref: PMID:23295789 {source="Europe PMC"}
xref: PMID:23521128 {source="Europe PMC"}
xref: PMID:23665800 {source="Europe PMC"}
xref: PMID:23667729 {source="Europe PMC"}
xref: PMID:23683018 {source="Europe PMC"}
xref: PMID:23725434 {source="Europe PMC"}
xref: PMID:23822827 {source="Europe PMC"}
xref: PMID:24098639 {source="Europe PMC"}
xref: PMID:24147900 {source="Europe PMC"}
xref: PMID:24223689 {source="Europe PMC"}
xref: Reaxys:999011 {source="Reaxys"}
xref: Wikipedia:Chlorambucil
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:33860 ! aromatic amine
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:37598 ! nitrogen mustard
is_a: CHEBI:50996 ! tertiary amino compound
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H19Cl2NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JCKYGMPEJWAADB-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "304.21160" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "303.07928" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl" xsd:string

[Term]
id: CHEBI:28863
name: flavanones
namespace: chebi_ontology
alt_id: CHEBI:13636
alt_id: CHEBI:24038
alt_id: CHEBI:24054
def: "Members of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives." []
subset: 3_STAR
synonym: "2,3-dihydroflavones" RELATED [ChEBI]
synonym: "a flavanone" RELATED [UniProt]
xref: MetaCyc:FLAVANONES
xref: Wikipedia:Flavanone
is_a: CHEBI:38672 ! flavans
is_a: CHEBI:3992 ! cyclic ketone
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H2O2R10" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "214.176" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "214.00548" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O1C2=C(C(C(C1C3=C(C(=C(C(=C3*)*)*)*)*)*)=O)C(=C(C(=C2*)*)*)*" xsd:string

[Term]
id: CHEBI:28868
name: fatty acid anion
namespace: chebi_ontology
alt_id: CHEBI:13634
alt_id: CHEBI:24022
alt_id: CHEBI:4985
def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." []
subset: 3_STAR
synonym: "a fatty acid" RELATED [UniProt]
synonym: "acido graso anionico" RELATED [ChEBI]
synonym: "acidos grasos anionicos" RELATED [ChEBI]
synonym: "Alkanate" RELATED [KEGG_COMPOUND]
synonym: "anion de l'acide gras" RELATED [ChEBI]
synonym: "Fatty acid anion" EXACT [KEGG_COMPOUND]
synonym: "fatty acid anions" RELATED [ChEBI]
synonym: "Fettsaeureanion" RELATED [ChEBI]
synonym: "Fettsaeureanionen" RELATED [ChEBI]
xref: KEGG:C02403
xref: PMID:18628202 {source="Europe PMC"}
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: is_conjugate_base_of CHEBI:35366 ! fatty acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.00950" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string

[Term]
id: CHEBI:28876
name: melphalan
namespace: chebi_ontology
alt_id: CHEBI:25815
alt_id: CHEBI:6742
def: "A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring." []
subset: 3_STAR
synonym: "3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine" RELATED [ChemIDplus]
synonym: "3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine" RELATED [ChemIDplus]
synonym: "4-(Bis(2-chloroethyl)amino)-L-phenylalanine" RELATED [ChemIDplus]
synonym: "4-[bis(2-chloroethyl)amino]-L-phenylalanine" EXACT IUPAC_NAME [IUPAC]
synonym: "L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine" RELATED [ChemIDplus]
synonym: "L-PAM" RELATED [ChemIDplus]
synonym: "L-Phenylalanine mustard" RELATED [ChemIDplus]
synonym: "L-Sarcolysine" RELATED [ChemIDplus]
synonym: "melfalano" RELATED INN [ChemIDplus]
synonym: "melphalan" RELATED INN [KEGG_DRUG]
synonym: "melphalanum" RELATED INN [ChemIDplus]
synonym: "p-Bis(beta-chloroethyl)aminophenylalanine" RELATED [ChemIDplus]
synonym: "p-Di-(2-chloroethyl)amino-L-phenylalanine" RELATED [ChemIDplus]
synonym: "p-L-Sarcolysin" RELATED [ChemIDplus]
synonym: "p-N,N-bis(2-chloroethyl)amino-L-phenylalanine" RELATED [ChEBI]
synonym: "p-N-Bis(2-chloroethyl)amino-L-phenylalanine" RELATED [ChemIDplus]
synonym: "Phenylalanine mustard" RELATED [ChemIDplus]
synonym: "Phenylalanine nitrogen mustard" RELATED [ChemIDplus]
xref: CAS:148-82-3 {source="KEGG DRUG"}
xref: CAS:148-82-3 {source="ChemIDplus"}
xref: Drug_Central:1678 {source="DrugCentral"}
xref: DrugBank:DB01042
xref: KEGG:D00369
xref: Patent:US108552
xref: Patent:US275057
xref: Patent:US3032584
xref: Patent:US3032585
xref: PMID:10820424 {source="Europe PMC"}
xref: PMID:10937717 {source="Europe PMC"}
xref: PMID:11680815 {source="Europe PMC"}
xref: PMID:11914777 {source="Europe PMC"}
xref: PMID:18481314 {source="Europe PMC"}
xref: PMID:445303 {source="Europe PMC"}
xref: PMID:7494795 {source="Europe PMC"}
xref: PMID:7605343 {source="Europe PMC"}
xref: PMID:8552138 {source="Europe PMC"}
xref: PMID:8951232 {source="Europe PMC"}
xref: PMID:9218926 {source="Europe PMC"}
xref: PMID:9250538 {source="Europe PMC"}
xref: Reaxys:2816456 {source="Reaxys"}
xref: Wikipedia:Melphalan
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:37598 ! nitrogen mustard
is_a: CHEBI:83822 ! non-proteinogenic L-alpha-amino acid
is_a: CHEBI:84144 ! L-phenylalanine derivative
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H18Cl2N2O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGDBTWWWUNNDEQ-LBPRGKRZSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "305.20000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "304.07453" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O" xsd:string

[Term]
id: CHEBI:28901
name: busulfan
namespace: chebi_ontology
alt_id: CHEBI:18936
alt_id: CHEBI:3225
def: "A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant." []
subset: 3_STAR
synonym: "1,4-Bis(methanesulfonoxy)butane" RELATED [ChemIDplus]
synonym: "1,4-Butanediol dimethanesulfonate" RELATED [ChemIDplus]
synonym: "1,4-Dimesyloxybutane" RELATED [ChemIDplus]
synonym: "1,4-Dimethanesulfonoxybutane" RELATED [ChemIDplus]
synonym: "Bisulfex" RELATED BRAND_NAME [ChEBI]
synonym: "Busulfan" EXACT [KEGG_DRUG]
synonym: "busulfan" RELATED INN [WHO_MedNet]
synonym: "busulfano" RELATED INN [WHO_MedNet]
synonym: "busulfanum" RELATED INN [WHO_MedNet]
synonym: "butane-1,4-diyl dimethanesulfonate" EXACT IUPAC_NAME [IUPAC]
synonym: "Leucosulfan" RELATED BRAND_NAME [ChEBI]
synonym: "Mablin" RELATED BRAND_NAME [ChEBI]
synonym: "Mielucin" RELATED BRAND_NAME [ChEBI]
synonym: "Misulban" RELATED BRAND_NAME [ChEBI]
synonym: "Mitostan" RELATED BRAND_NAME [ChEBI]
synonym: "Myeloleukon" RELATED BRAND_NAME [ChEBI]
synonym: "Myleran" RELATED BRAND_NAME [KEGG_DRUG]
synonym: "Tetramethylene bis(methanesulfonate)" RELATED [ChemIDplus]
xref: Beilstein:1791786 {source="Beilstein"}
xref: CAS:55-98-1 {source="ChemIDplus"}
xref: CAS:55-98-1 {source="KEGG DRUG"}
xref: Drug_Central:438 {source="DrugCentral"}
xref: DrugBank:DB01008
xref: KEGG:C06862
xref: KEGG:D00248
xref: LINCS:LSM-5388
xref: Patent:US2917432
xref: PMID:10523796 {source="Europe PMC"}
xref: PMID:19361744 {source="Europe PMC"}
xref: PMID:19611402 {source="Europe PMC"}
xref: Reaxys:1791786 {source="Reaxys"}
xref: Wikipedia:Busulfan
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25223 ! methanesulfonate ester
relationship: has_functional_parent CHEBI:41189 ! butane-1,4-diol
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:50905 ! has role teratogenic agent
relationship: RO:0000087 CHEBI:67105 ! has role insect sterilant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H14O6S2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COVZYZSDYWQREU-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "246.30200" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "246.02318" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS(=O)(=O)OCCCCOS(C)(=O)=O" xsd:string

[Term]
id: CHEBI:28938
name: ammonium
namespace: chebi_ontology
alt_id: CHEBI:22534
alt_id: CHEBI:49783
alt_id: CHEBI:7435
def: "An onium cation obtained by protonation of ammonia." []
subset: 3_STAR
synonym: "[NH4](+)" RELATED [MolBase]
synonym: "ammonium" EXACT IUPAC_NAME [IUPAC]
synonym: "ammonium" EXACT [ChEBI]
synonym: "ammonium cation" RELATED [ChemIDplus]
synonym: "ammonium ion" RELATED [PDBeChem]
synonym: "Ammonium(1+)" RELATED [ChemIDplus]
synonym: "azanium" EXACT IUPAC_NAME [IUPAC]
synonym: "NH4(+)" RELATED [UniProt]
synonym: "NH4(+)" RELATED [IUPAC]
synonym: "NH4+" RELATED [KEGG_COMPOUND]
xref: CAS:14798-03-9 {source="NIST Chemistry WebBook"}
xref: CAS:14798-03-9 {source="ChemIDplus"}
xref: Gmelin:84 {source="Gmelin"}
xref: KEGG:C01342
xref: MetaCyc:AMMONIUM
xref: MolBase:929
xref: PDBeChem:NH4
xref: PMID:11319011 {source="Europe PMC"}
xref: PMID:11341317 {source="Europe PMC"}
xref: PMID:12096804 {source="Europe PMC"}
xref: PMID:14512268 {source="Europe PMC"}
xref: PMID:14879753 {source="Europe PMC"}
xref: PMID:16345391 {source="Europe PMC"}
xref: PMID:16903292 {source="Europe PMC"}
xref: PMID:17392693 {source="Europe PMC"}
xref: PMID:18515490 {source="Europe PMC"}
xref: PMID:19199063 {source="Europe PMC"}
xref: PMID:19596600 {source="Europe PMC"}
xref: PMID:19682559 {source="Europe PMC"}
xref: PMID:19716251 {source="Europe PMC"}
xref: PMID:21993530 {source="Europe PMC"}
xref: PMID:22265469 {source="Europe PMC"}
xref: PMID:22524020 {source="Europe PMC"}
xref: PMID:22562341 {source="Europe PMC"}
xref: PMID:22631217 {source="Europe PMC"}
xref: Reaxys:16093784 {source="Reaxys"}
xref: Wikipedia:Ammonium
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:50313 ! onium cation
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: is_conjugate_acid_of CHEBI:16134 ! ammonia
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H4N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3N/h1H3/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "18.03850" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.03383" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N+]([H])([H])[H]" xsd:string

[Term]
id: CHEBI:28954
name: fagaronine
namespace: chebi_ontology
alt_id: CHEBI:24011
alt_id: CHEBI:4968
subset: 3_STAR
synonym: "2-hydroxy-3,8,9-trimethoxy-5-methylbenzo[c]phenanthridinium" EXACT IUPAC_NAME [IUPAC]
synonym: "Fagaronine" EXACT [KEGG_COMPOUND]
xref: CAS:52259-65-1 {source="KEGG COMPOUND"}
xref: KEGG:C09438
xref: KNApSAcK:C00001857
is_a: CHEBI:38517 ! benzophenanthridine alkaloid
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H20NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H19NO4/c1-22-11-13-8-19(25-3)20(26-4)9-15(13)14-6-5-12-7-17(23)18(24-2)10-16(12)21(14)22/h5-11H,1-4H3/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OOKZVPUCASIEBL-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "350.38784" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "350.13868" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1cc2c(ccc3c4cc(OC)c(OC)cc4c[n+](C)c23)cc1O" xsd:string

[Term]
id: CHEBI:28965
name: dicarboxylic acid dianion
namespace: chebi_ontology
alt_id: CHEBI:13632
alt_id: CHEBI:23688
alt_id: CHEBI:23689
alt_id: CHEBI:38711
def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." []
subset: 3_STAR
synonym: "a dicarboxylate" RELATED [UniProt]
synonym: "dicarboxylate" RELATED [ChEBI]
synonym: "dicarboxylates" RELATED [ChEBI]
synonym: "dicarboxylic acid dianion" EXACT [ChEBI]
synonym: "dicarboxylic acid dianions" RELATED [ChEBI]
is_a: CHEBI:35693 ! dicarboxylic acid anion
is_a: CHEBI:38716 ! carboxylic acid dianion
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2O4R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "88.019" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "87.97966" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[*]C([O-])=O" xsd:string

[Term]
id: CHEBI:28976
name: carbonic acid
namespace: chebi_ontology
alt_id: CHEBI:13351
alt_id: CHEBI:23017
alt_id: CHEBI:23744
alt_id: CHEBI:3401
subset: 3_STAR
synonym: "[CO(OH)2]" RELATED [IUPAC]
synonym: "Carbonic acid" EXACT [KEGG_COMPOUND]
synonym: "carbonic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Dihydrogen carbonate" RELATED [KEGG_COMPOUND]
synonym: "dihydroxidooxidocarbon" EXACT IUPAC_NAME [IUPAC]
synonym: "H2CO3" RELATED [KEGG_COMPOUND]
synonym: "H2CO3" RELATED [IUPAC]
synonym: "Koehlensaeure" RELATED [ChEBI]
xref: CAS:463-79-6 {source="ChemIDplus"}
xref: CAS:463-79-6 {source="KEGG COMPOUND"}
xref: Gmelin:25554 {source="Gmelin"}
xref: KEGG:C01353
xref: PDBeChem:CO3
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36961 ! chalcocarbonic acid
relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "62.02478" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.00039" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(O)=O" xsd:string

[Term]
id: CHEBI:29036
name: copper(2+)
namespace: chebi_ontology
alt_id: CHEBI:20882
alt_id: CHEBI:23380
alt_id: CHEBI:49550
def: "An ion of copper carrying a double positive charge." []
subset: 3_STAR
synonym: "COPPER (II) ION" RELATED [PDBeChem]
synonym: "copper(2+)" EXACT IUPAC_NAME [IUPAC]
synonym: "copper(2+) ion" EXACT IUPAC_NAME [IUPAC]
synonym: "copper(II) cation" EXACT IUPAC_NAME [IUPAC]
synonym: "copper(II) cation" RELATED [ChEBI]
synonym: "copper, ion (Cu2+)" RELATED [ChemIDplus]
synonym: "Cu(2+)" RELATED [UniProt]
synonym: "Cu(II)" RELATED [ChEBI]
synonym: "Cu2+" RELATED [ChEBI]
synonym: "cupric ion" RELATED [ChEBI]
xref: CAS:15158-11-9 {source="ChemIDplus"}
xref: Gmelin:6855 {source="Gmelin"}
xref: PDBeChem:CU
xref: PMID:23900424 {source="Europe PMC"}
xref: PMID:24168430 {source="Europe PMC"}
xref: Reaxys:3587177 {source="Reaxys"}
is_a: CHEBI:23378 ! copper cation
is_a: CHEBI:30412 ! monoatomic dication
is_a: CHEBI:60240 ! divalent metal cation
property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cu" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cu/q+2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JPVYNHNXODAKFH-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "63.54600" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.92850" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cu++]" xsd:string

[Term]
id: CHEBI:29067
name: carboxylic acid anion
namespace: chebi_ontology
alt_id: CHEBI:13626
alt_id: CHEBI:13945
alt_id: CHEBI:23026
alt_id: CHEBI:58657
def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." []
subset: 3_STAR
synonym: "a carboxylate" RELATED [UniProt]
synonym: "carboxylic acid anions" RELATED [ChEBI]
synonym: "carboxylic anions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.00950" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string

[Term]
id: CHEBI:29101
name: sodium(1+)
namespace: chebi_ontology
alt_id: CHEBI:26717
alt_id: CHEBI:49766
alt_id: CHEBI:9175
def: "A monoatomic monocation obtained from sodium." []
subset: 3_STAR
synonym: "Na(+)" RELATED [UniProt]
synonym: "Na(+)" RELATED [IUPAC]
synonym: "Na+" RELATED [KEGG_COMPOUND]
synonym: "sodium cation" EXACT IUPAC_NAME [IUPAC]
synonym: "SODIUM ION" RELATED [PDBeChem]
synonym: "sodium(1+)" EXACT IUPAC_NAME [IUPAC]
synonym: "sodium(1+) ion" EXACT IUPAC_NAME [IUPAC]
synonym: "sodium(I) cation" EXACT IUPAC_NAME [IUPAC]
xref: CAS:17341-25-2 {source="ChemIDplus"}
xref: CAS:17341-25-2 {source="NIST Chemistry WebBook"}
xref: Gmelin:15196 {source="Gmelin"}
xref: KEGG:C01330
xref: PDBeChem:NA
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33504 ! alkali metal cation
is_a: CHEBI:37246 ! elemental sodium
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Na" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Na/q+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FKNQFGJONOIPTF-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "22.98977" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "22.98922" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na+]" xsd:string

[Term]
id: CHEBI:29214
name: sulfonic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "[SHO2(OH)]" RELATED [IUPAC]
synonym: "acide sulfonique" RELATED [ChEBI]
synonym: "HSHO3" RELATED [IUPAC]
synonym: "hydridohydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC]
synonym: "sulfonic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Sulfonsaeure" RELATED [ChEBI]
synonym: "sulphonic acid" RELATED [ChEBI]
xref: Gmelin:1404640 {source="Gmelin"}
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: is_conjugate_acid_of CHEBI:33543 ! sulfonate
relationship: is_tautomer_of CHEBI:48854 ! sulfurous acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "82.08008" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.97247" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S(O)(=O)=O" xsd:string

[Term]
id: CHEBI:29228
name: hydrogen fluoride
namespace: chebi_ontology
def: "A diatomic molecule containing covalently bonded hydrogen and fluorine atoms." []
subset: 3_STAR
synonym: "[HF]" RELATED [IUPAC]
synonym: "fluorane" EXACT IUPAC_NAME [IUPAC]
synonym: "Fluoride" RELATED [KEGG_COMPOUND]
synonym: "fluoridohydrogen" EXACT IUPAC_NAME [IUPAC]
synonym: "fluorure d'hydrogene" RELATED [ChEBI]
synonym: "Fluorwasserstoff" RELATED [ChEBI]
synonym: "HF" RELATED [IUPAC]
synonym: "hydrofluoric acid" RELATED [ChemIDplus]
synonym: "Hydrogen fluoride" EXACT [KEGG_COMPOUND]
synonym: "hydrogen fluoride" EXACT IUPAC_NAME [IUPAC]
synonym: "Hydrogenfluorid" RELATED [ChEBI]
xref: CAS:7664-39-3 {source="NIST Chemistry WebBook"}
xref: CAS:7664-39-3 {source="ChemIDplus"}
xref: CAS:7664-39-3 {source="KEGG COMPOUND"}
xref: Drug_Central:4499 {source="DrugCentral"}
xref: Gmelin:166 {source="Gmelin"}
xref: KEGG:C16487
is_a: CHEBI:18140 ! hydrogen halide
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: is_conjugate_acid_of CHEBI:17051 ! fluoride
relationship: is_conjugate_base_of CHEBI:50314 ! fluoronium
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "FH" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/FH/h1H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KRHYYFGTRYWZRS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "20.00634" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "20.00623" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "F[H]" xsd:string

[Term]
id: CHEBI:29234
name: triton
namespace: chebi_ontology
def: "Nucleus of the (3)H atom." []
subset: 3_STAR
synonym: "(3)1H(+)" RELATED [IUPAC]
synonym: "(3)H(+)" RELATED [IUPAC]
synonym: "t" RELATED [IUPAC]
synonym: "T(+)" RELATED [IUPAC]
synonym: "t(+)" RELATED [IUPAC]
synonym: "tritium(1+)" EXACT IUPAC_NAME [IUPAC]
synonym: "triton" EXACT IUPAC_NAME [IUPAC]
xref: Gmelin:90855 {source="Gmelin"}
is_a: CHEBI:15378 ! hydron
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "T" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/p+1/i/hT" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GPRLSGONYQIRFK-MNYXATJNSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "3.016" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "3.01550" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[3H+]" xsd:string

[Term]
id: CHEBI:29238
name: tritium atom
namespace: chebi_ontology
def: "The radioactive isotope of hydrogen with relative atomic mass 3.016049 and half-life of 12.33 years (from Greek taurhoiotatauomicronsigma, third)." []
subset: 3_STAR
synonym: "(3)1H" RELATED [IUPAC]
synonym: "(3)H" RELATED [IUPAC]
synonym: "hydrogen-3" RELATED [ChEBI]
synonym: "T" RELATED [IUPAC]
synonym: "tritio" RELATED [ChEBI]
synonym: "tritium" EXACT IUPAC_NAME [IUPAC]
synonym: "tritium" RELATED [ChEBI]
synonym: "ueberschwerer Wasserstoff" RELATED [ChEBI]
is_a: CHEBI:49637 ! hydrogen atom
relationship: BFO:0000051 CHEBI:29234 ! has part triton
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "T" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2/h1H/i1+2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UFHFLCQGNIYNRP-NJFSPNSNSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "3.016" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "3.01605" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[3H]" xsd:string

[Term]
id: CHEBI:29254
name: dihydrogenborate
namespace: chebi_ontology
subset: 3_STAR
synonym: "[BO(OH)2](-)" RELATED [IUPAC]
synonym: "dihydrogen(trioxidoborate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydrogenborate" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydroxidooxidoborate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "H2BO3(-)" RELATED [IUPAC]
xref: Gmelin:49252 {source="Gmelin"}
is_a: CHEBI:22909 ! borate ion
relationship: is_conjugate_acid_of CHEBI:29255 ! hydrogenborate
relationship: is_conjugate_base_of CHEBI:33118 ! boric acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "BH2O3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/BH2O3/c2-1(3)4/h2-3H/q-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "URSLCTBXQMKCFE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.82508" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "61.01025" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OB([O-])O[H]" xsd:string

[Term]
id: CHEBI:29255
name: hydrogenborate
namespace: chebi_ontology
subset: 3_STAR
synonym: "[BO2(OH)](2-)" RELATED [IUPAC]
synonym: "HBO3(2-)" RELATED [IUPAC]
synonym: "hydrogen(trioxidoborate)(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogenborate" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxidodioxidoborate(2-)" EXACT IUPAC_NAME [IUPAC]
xref: Gmelin:674511 {source="Gmelin"}
is_a: CHEBI:22909 ! borate ion
relationship: is_conjugate_acid_of CHEBI:22908 ! borate
relationship: is_conjugate_base_of CHEBI:29254 ! dihydrogenborate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "BHO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/BHO3/c2-1(3)4/h2H/q-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JSSGFLRDNVXLHY-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "59.81714" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.00297" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OB([O-])[O-]" xsd:string

[Term]
id: CHEBI:29281
name: alkyl sulfate
namespace: chebi_ontology
alt_id: CHEBI:13810
alt_id: CHEBI:22325
alt_id: CHEBI:2583
subset: 3_STAR
synonym: "alkyl sulfates" RELATED [ChEBI]
is_a: CHEBI:25704 ! organic sulfate
is_a: CHEBI:26819 ! sulfuric ester
relationship: is_conjugate_acid_of CHEBI:83414 ! alkyl sulfate(1-)

[Term]
id: CHEBI:29337
name: azanide
namespace: chebi_ontology
subset: 3_STAR
synonym: "amide" EXACT IUPAC_NAME [IUPAC]
synonym: "azanide" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydridonitrate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "NH2(-)" RELATED [IUPAC]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-)
relationship: is_conjugate_base_of CHEBI:16134 ! ammonia
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2N/h1H2/q-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HYGWNUKOUCZBND-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "16.02262" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01927" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N-][H]" xsd:string

[Term]
id: CHEBI:29340
name: hydridonitrate(2-)
namespace: chebi_ontology
def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." []
subset: 3_STAR
synonym: "azanediide" EXACT IUPAC_NAME [IUPAC]
synonym: "hydridonitrate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "imide" RELATED [IUPAC]
synonym: "NH(2-)" RELATED [IUPAC]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: is_conjugate_base_of CHEBI:29337 ! azanide
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HN" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/HN/h1H/q-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DZQYTNGKSBCIOE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.01468" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01200" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[N--][H]" xsd:string

[Term]
id: CHEBI:29347
name: monocarboxylic acid amide
namespace: chebi_ontology
alt_id: CHEBI:13211
alt_id: CHEBI:22207
alt_id: CHEBI:25383
alt_id: CHEBI:6977
def: "A carboxamide derived from a monocarboxylic acid." []
subset: 3_STAR
synonym: "monocarboxylic acid amides" RELATED [ChEBI]
is_a: CHEBI:37622 ! carboxamide
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "42.01680" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N([*])C([*])=O" xsd:string

[Term]
id: CHEBI:29785
name: nitro group
namespace: chebi_ontology
subset: 3_STAR
synonym: "-NO2" RELATED [IUPAC]
synonym: "nitro" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33246 ! inorganic group
is_a: CHEBI:51144 ! nitrogen group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "46.00550" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "45.99290" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*[N+](=O)[O-]" xsd:string

[Term]
id: CHEBI:29865
name: benzo[a]pyrene
namespace: chebi_ontology
alt_id: CHEBI:22716
alt_id: CHEBI:3045
def: "An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings." []
subset: 3_STAR
synonym: "(B(a)P)" RELATED [ChEBI]
synonym: "3,4-Benzopyrene" RELATED [NIST_Chemistry_WebBook]
synonym: "3,4-Benzpyrene" RELATED [NIST_Chemistry_WebBook]
synonym: "3,4-BP" RELATED [NIST_Chemistry_WebBook]
synonym: "Benzo(a)pyrene" RELATED [ChemIDplus]
synonym: "Benzo[a]pyrene" EXACT [KEGG_COMPOUND]
synonym: "benzo[def]chrysene" RELATED [ChEBI]
synonym: "benzo[pqr]tetraphene" EXACT IUPAC_NAME [IUPAC]
synonym: "Benzpyrene" RELATED [KEGG_COMPOUND]
synonym: "BP" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1911333 {source="Beilstein"}
xref: CAS:50-32-8 {source="ChemIDplus"}
xref: CAS:50-32-8 {source="NIST Chemistry WebBook"}
xref: CAS:50-32-8 {source="KEGG COMPOUND"}
xref: Gmelin:262573 {source="Gmelin"}
xref: KEGG:C07535
xref: LINCS:LSM-2198
xref: PMID:11932001 {source="Europe PMC"}
xref: PMID:16256111 {source="Europe PMC"}
xref: PMID:16381670 {source="Europe PMC"}
xref: PMID:1844333 {source="Europe PMC"}
xref: PMID:26530167 {source="Europe PMC"}
xref: PMID:26703252 {source="Europe PMC"}
xref: PMID:7561049 {source="Europe PMC"}
xref: PMID:7721048 {source="Europe PMC"}
xref: Reaxys:1911333 {source="Reaxys"}
xref: Wikipedia:Benzo(a)pyrene
is_a: CHEBI:35300 ! ortho- and peri-fused polycyclic arene
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H12" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FMMWHPNWAFZXNH-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "252.30928" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "252.09390" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2c(c1)cc1ccc3cccc4ccc2c1c34" xsd:string

[Term]
id: CHEBI:29922
name: sulfo group
namespace: chebi_ontology
subset: 3_STAR
synonym: "-S(O)2(OH)" RELATED [IUPAC]
synonym: "hydroxydioxo-lambda(6)-sulfanyl" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxysulfonyl" EXACT IUPAC_NAME [IUPAC]
synonym: "sulfo" EXACT IUPAC_NAME [IUPAC]
synonym: "SULFO GROUP" EXACT [PDBeChem]
xref: PDBeChem:SFO
is_a: CHEBI:33246 ! inorganic group
relationship: is_substituent_group_from CHEBI:29214 ! sulfonic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96464" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "S(=O)(O)(*)=O" xsd:string

[Term]
id: CHEBI:29985
name: L-glutamate(1-)
namespace: chebi_ontology
alt_id: CHEBI:13107
alt_id: CHEBI:21301
def: "An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group" []
subset: 3_STAR
synonym: "(2S)-2-ammoniopentanedioate" RELATED [IUPAC]
synonym: "hydrogen L-glutamate" EXACT IUPAC_NAME [IUPAC]
synonym: "L-glutamate" RELATED [ChEBI]
synonym: "L-glutamate" RELATED [UniProt]
synonym: "L-glutamate(1-)" EXACT [JCBN]
synonym: "L-glutamic acid monoanion" RELATED [JCBN]
synonym: "L-glutamic acid, ion(1-)" RELATED [ChemIDplus]
xref: CAS:11070-68-1 {source="ChemIDplus"}
xref: Gmelin:936654 {source="Gmelin"}
xref: MetaCyc:GLT
is_a: CHEBI:14321 ! glutamate(1-)
is_a: CHEBI:62031 ! polar amino acid zwitterion
relationship: is_conjugate_acid_of CHEBI:29988 ! L-glutamate(2-)
relationship: is_conjugate_base_of CHEBI:16015 ! L-glutamic acid
relationship: is_enantiomer_of CHEBI:29986 ! D-glutamate(1-)
relationship: RO:0000087 CHEBI:24319 ! has role EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-VKHMYHEASA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "146.12136" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "146.04588" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H](CCC([O-])=O)C([O-])=O" xsd:string

[Term]
id: CHEBI:29986
name: D-glutamate(1-)
namespace: chebi_ontology
alt_id: CHEBI:12979
alt_id: CHEBI:21022
def: "An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group" []
subset: 3_STAR
synonym: "(2R)-2-ammoniopentanedioate" RELATED [IUPAC]
synonym: "D-glutamate" RELATED [UniProt]
synonym: "D-glutamate(1-)" EXACT [JCBN]
synonym: "D-glutamic acid monoanion" RELATED [JCBN]
synonym: "hydrogen D-glutamate" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:8319427 {source="Beilstein"}
xref: MetaCyc:D-GLT
is_a: CHEBI:14321 ! glutamate(1-)
relationship: is_conjugate_acid_of CHEBI:29989 ! D-glutamate(2-)
relationship: is_conjugate_base_of CHEBI:15966 ! D-glutamic acid
relationship: is_enantiomer_of CHEBI:29985 ! L-glutamate(1-)
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-GSVOUGTGSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "146.12136" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "146.04588" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H](CCC([O-])=O)C([O-])=O" xsd:string

[Term]
id: CHEBI:29987
name: glutamate(2-)
namespace: chebi_ontology
def: "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-)." []
subset: 3_STAR
synonym: "2-aminopentanedioate" EXACT IUPAC_NAME [IUPAC]
synonym: "glutamate" EXACT IUPAC_NAME [IUPAC]
synonym: "glutamate(2-)" EXACT [JCBN]
synonym: "glutamic acid dianion" RELATED [JCBN]
xref: Beilstein:4134100 {source="Beilstein"}
xref: Gmelin:327903 {source="Gmelin"}
xref: Reaxys:4134100 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:28965 ! dicarboxylic acid dianion
relationship: is_conjugate_base_of CHEBI:14321 ! glutamate(1-)
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H7NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "145.11342" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "145.03860" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CCC([O-])=O)C([O-])=O" xsd:string

[Term]
id: CHEBI:29988
name: L-glutamate(2-)
namespace: chebi_ontology
def: "An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid." []
subset: 3_STAR
synonym: "(2S)-2-aminopentanedioate" EXACT IUPAC_NAME [IUPAC]
synonym: "L-glutamate" EXACT IUPAC_NAME [IUPAC]
synonym: "L-glutamate(2-)" EXACT [JCBN]
synonym: "L-glutamic acid dianion" RELATED [JCBN]
xref: Gmelin:327905 {source="Gmelin"}
is_a: CHEBI:29987 ! glutamate(2-)
is_a: CHEBI:59814 ! L-alpha-amino acid anion
relationship: is_conjugate_base_of CHEBI:29985 ! L-glutamate(1-)
relationship: is_enantiomer_of CHEBI:29989 ! D-glutamate(2-)
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H7NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2/t3-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-VKHMYHEASA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "145.11342" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "145.03860" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](CCC([O-])=O)C([O-])=O" xsd:string

[Term]
id: CHEBI:29989
name: D-glutamate(2-)
namespace: chebi_ontology
subset: 3_STAR
synonym: "(2R)-2-aminopentanedioate" EXACT IUPAC_NAME [IUPAC]
synonym: "D-glutamate" EXACT IUPAC_NAME [IUPAC]
synonym: "D-glutamate(2-)" EXACT [JCBN]
synonym: "D-glutamic acid dianion" RELATED [JCBN]
xref: Beilstein:8143000 {source="Beilstein"}
xref: Gmelin:327904 {source="Gmelin"}
is_a: CHEBI:29987 ! glutamate(2-)
relationship: is_conjugate_base_of CHEBI:29986 ! D-glutamate(1-)
relationship: is_enantiomer_of CHEBI:29988 ! L-glutamate(2-)
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H7NO4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2/t3-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WHUUTDBJXJRKMK-GSVOUGTGSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "145.11342" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "145.03860" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H](CCC([O-])=O)C([O-])=O" xsd:string

[Term]
id: CHEBI:30087
name: guanidinium
namespace: chebi_ontology
subset: 3_STAR
synonym: "[C(NH2)3](+)" RELATED [ChEBI]
synonym: "diaminomethaniminium" RELATED [IUPAC]
synonym: "guanidine" RELATED [UniProt]
synonym: "guanidinium" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:1902006 {source="Beilstein"}
xref: Gmelin:239627 {source="Gmelin"}
is_a: CHEBI:60251 ! guanidinium ion
relationship: is_conjugate_acid_of CHEBI:42820 ! guanidine
relationship: is_conjugate_acid_of CHEBI:616459 ! carbamimidoylazanium
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH6N3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4)/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZRALSGWEFCBTJO-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.07856" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.05562" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(N)=[NH2+]" xsd:string

[Term]
id: CHEBI:30412
name: monoatomic dication
namespace: chebi_ontology
alt_id: CHEBI:23856
alt_id: CHEBI:4665
subset: 3_STAR
synonym: "Divalent cation" RELATED [KEGG_COMPOUND]
synonym: "divalent inorganic cations" RELATED [ChEBI]
synonym: "monoatomic dications" RELATED [ChEBI]
xref: KEGG:C00572
is_a: CHEBI:23906 ! monoatomic cation
property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*++]" xsd:string

[Term]
id: CHEBI:30751
name: formic acid
namespace: chebi_ontology
alt_id: CHEBI:24082
alt_id: CHEBI:42460
alt_id: CHEBI:5145
def: "The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects." []
subset: 3_STAR
synonym: "Acide formique" RELATED [ChemIDplus]
synonym: "Ameisensaeure" RELATED [ChemIDplus]
synonym: "aminic acid" RELATED [ChemIDplus]
synonym: "bilorin" RELATED [ChemIDplus]
synonym: "FORMIC ACID" EXACT [PDBeChem]
synonym: "Formic acid" EXACT [KEGG_COMPOUND]
synonym: "formic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "formylic acid" RELATED [ChemIDplus]
synonym: "H-COOH" RELATED [IUPAC]
synonym: "HCO2H" RELATED [ChEBI]
synonym: "HCOOH" RELATED [NIST_Chemistry_WebBook]
synonym: "hydrogen carboxylic acid" RELATED [ChemIDplus]
synonym: "Methanoic acid" RELATED [KEGG_COMPOUND]
synonym: "methoic acid" RELATED [ChEBI]
xref: Beilstein:1209246 {source="Beilstein"}
xref: BPDB:1749
xref: CAS:64-18-6 {source="NIST Chemistry WebBook"}
xref: CAS:64-18-6 {source="ChemIDplus"}
xref: CAS:64-18-6 {source="KEGG COMPOUND"}
xref: DrugBank:DB01942
xref: Gmelin:1008 {source="Gmelin"}
xref: HMDB:HMDB0000142
xref: KEGG:C00058
xref: KNApSAcK:C00001182
xref: LIPID_MAPS_instance:LMFA01010040 {source="LIPID MAPS"}
xref: MetaCyc:FORMATE
xref: Patent:CN101481304
xref: PDBeChem:FMT
xref: PMID:12591956 {source="Europe PMC"}
xref: PMID:14637377 {source="Europe PMC"}
xref: PMID:15811469 {source="Europe PMC"}
xref: PMID:16120414 {source="Europe PMC"}
xref: PMID:16185830 {source="Europe PMC"}
xref: PMID:16222862 {source="Europe PMC"}
xref: PMID:16230297 {source="Europe PMC"}
xref: PMID:16445901 {source="Europe PMC"}
xref: PMID:16465784 {source="Europe PMC"}
xref: PMID:18034701 {source="Europe PMC"}
xref: PMID:18397576 {source="Europe PMC"}
xref: PMID:22080171 {source="Europe PMC"}
xref: PMID:22280475 {source="Europe PMC"}
xref: PMID:22304812 {source="Europe PMC"}
xref: PMID:22385261 {source="Europe PMC"}
xref: PMID:22447125 {source="Europe PMC"}
xref: PMID:22483350 {source="Europe PMC"}
xref: PMID:22499553 {source="Europe PMC"}
xref: PMID:22540994 {source="Europe PMC"}
xref: PMID:22606986 {source="Europe PMC"}
xref: PMID:22622393 {source="Europe PMC"}
xref: PMID:3946945 {source="Europe PMC"}
xref: PMID:7361809 {source="Europe PMC"}
xref: Reaxys:1209246 {source="Reaxys"}
xref: Wikipedia:Formic_acid
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: is_conjugate_acid_of CHEBI:15740 ! formate
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
relationship: RO:0000087 CHEBI:74783 ! has role astringent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDAGIHXWWSANSR-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "46.02538" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "46.00548" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(O)=O" xsd:string

[Term]
id: CHEBI:30879
name: alcohol
namespace: chebi_ontology
alt_id: CHEBI:13804
alt_id: CHEBI:22288
alt_id: CHEBI:2553
def: "A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." []
subset: 3_STAR
synonym: "Alcohol" EXACT [KEGG_COMPOUND]
synonym: "alcohols" EXACT IUPAC_NAME [IUPAC]
synonym: "an alcohol" RELATED [UniProt]
xref: KEGG:C00069
is_a: CHEBI:33822 ! organic hydroxy compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HOR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "17.007" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[*]" xsd:string

[Term]
id: CHEBI:30969
name: aziridine
namespace: chebi_ontology
alt_id: CHEBI:24004
alt_id: CHEBI:2954
subset: 3_STAR
synonym: "azacyclopropane" RELATED [NIST_Chemistry_WebBook]
synonym: "Aziridine" EXACT [KEGG_COMPOUND]
synonym: "aziridine" EXACT IUPAC_NAME [IUPAC]
synonym: "dimethyleneimine" RELATED [NIST_Chemistry_WebBook]
synonym: "EI" RELATED [NIST_Chemistry_WebBook]
synonym: "ethyleneimine" RELATED [ChemIDplus]
synonym: "ethylenimine" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:102380 {source="Beilstein"}
xref: CAS:151-56-4 {source="NIST Chemistry WebBook"}
xref: CAS:151-56-4 {source="KEGG COMPOUND"}
xref: CAS:151-56-4 {source="ChemIDplus"}
xref: Gmelin:616 {source="Gmelin"}
xref: KEGG:C11687
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22681 ! aziridines
is_a: CHEBI:36389 ! saturated organic heteromonocyclic parent
is_a: CHEBI:37949 ! azacycloalkane
relationship: is_conjugate_base_of CHEBI:50929 ! aziridinium
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H5N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H5N/c1-2-3-1/h3H,1-2H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NOWKCMXCCJGMRR-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "43.06784" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.04220" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1CN1" xsd:string

[Term]
id: CHEBI:31011
name: valerate
namespace: chebi_ontology
alt_id: CHEBI:14751
alt_id: CHEBI:25890
def: "A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals." []
subset: 3_STAR
synonym: "CH3-[CH2]3-COO(-)" RELATED [IUPAC]
synonym: "n-propylacetate" RELATED [ChEBI]
synonym: "pentanoate" EXACT IUPAC_NAME [IUPAC]
synonym: "pentanoate" RELATED [UniProt]
synonym: "pentanoic acid, ion(1-)" RELATED [ChemIDplus]
xref: Beilstein:3903735 {source="Beilstein"}
xref: CAS:10023-74-2 {source="ChemIDplus"}
xref: Gmelin:325619 {source="Gmelin"}
xref: PMID:17314444 {source="Europe PMC"}
xref: PMID:18783570 {source="Europe PMC"}
xref: Reaxys:3903735 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:58951 ! short-chain fatty acid anion
is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion
relationship: is_conjugate_base_of CHEBI:17418 ! valeric acid
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NQPDZGIKBAWPEJ-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "101.12376" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.06080" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCC([O-])=O" xsd:string

[Term]
id: CHEBI:32456
name: cysteinate(1-)
namespace: chebi_ontology
def: "A sulfur-containing amino-acid anion that is the conjugate base of cysteine, obtained by deprotonation of the carboxy group." []
subset: 3_STAR
synonym: "2-amino-3-mercaptopropanoate" RELATED [ChEBI]
synonym: "2-amino-3-sulfanylpropanoate" RELATED [IUPAC]
synonym: "cys(-)" RELATED [IUPAC]
synonym: "cysteinate(1-)" EXACT [JCBN]
synonym: "cysteine monoanion" RELATED [JCBN]
synonym: "hydrogen cysteinate" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:4128885 {source="Beilstein"}
xref: Gmelin:363235 {source="Gmelin"}
xref: Reaxys:4128885 {source="Reaxys"}
is_a: CHEBI:33558 ! alpha-amino-acid anion
is_a: CHEBI:63470 ! sulfur-containing amino-acid anion
relationship: is_conjugate_acid_of CHEBI:32457 ! cysteinate(2-)
relationship: is_conjugate_base_of CHEBI:15356 ! cysteine
relationship: is_conjugate_base_of CHEBI:35237 ! cysteine zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6NO2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "120.15128" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.01247" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CS)C([O-])=O" xsd:string

[Term]
id: CHEBI:32457
name: cysteinate(2-)
namespace: chebi_ontology
subset: 3_STAR
synonym: "2-amino-3-sulfidopropanoate" RELATED [IUPAC]
synonym: "cysteinate" EXACT IUPAC_NAME [IUPAC]
synonym: "cysteinate(2-)" EXACT [JCBN]
synonym: "cysteine dianion" RELATED [JCBN]
xref: Gmelin:49990 {source="Gmelin"}
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: is_conjugate_base_of CHEBI:32456 ! cysteinate(1-)
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H5NO2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "119.14334" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "119.00520" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(C[S-])C([O-])=O" xsd:string

[Term]
id: CHEBI:32458
name: cysteinium
namespace: chebi_ontology
subset: 3_STAR
synonym: "1-carboxy-2-mercaptoethanaminium" RELATED [ChEBI]
synonym: "1-carboxy-2-sulfanylethanaminium" EXACT IUPAC_NAME [IUPAC]
synonym: "cysteine cation" RELATED [JCBN]
synonym: "cysteinium" EXACT [JCBN]
synonym: "H2cys(+)" RELATED [IUPAC]
xref: Gmelin:325859 {source="Gmelin"}
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: is_conjugate_acid_of CHEBI:15356 ! cysteine
relationship: is_conjugate_acid_of CHEBI:35237 ! cysteine zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H8NO2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "122.16716" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "122.02703" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CS)C(O)=O" xsd:string

[Term]
id: CHEBI:32486
name: L-phenylalaninate
namespace: chebi_ontology
def: "An optically active form of phenylalaninate having L-configuration." []
subset: 3_STAR
synonym: "(2S)-2-amino-3-phenylpropanoate" RELATED [IUPAC]
synonym: "L-phenylalaninate" EXACT IUPAC_NAME [IUPAC]
synonym: "L-phenylalanine anion" RELATED [JCBN]
xref: Beilstein:4136718 {source="Beilstein"}
xref: Gmelin:329084 {source="Gmelin"}
xref: PMID:21956539 {source="Europe PMC"}
xref: Reaxys:4136718 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32504 ! phenylalaninate
is_a: CHEBI:59814 ! L-alpha-amino acid anion
relationship: is_conjugate_base_of CHEBI:17295 ! L-phenylalanine
relationship: is_enantiomer_of CHEBI:32494 ! D-phenylalaninate
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H10NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p-1/t8-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "164.18120" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "164.07170" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](Cc1ccccc1)C([O-])=O" xsd:string

[Term]
id: CHEBI:32487
name: L-phenylalaninium
namespace: chebi_ontology
def: "An optically active form of phenylalaninium having L-configuration." []
subset: 3_STAR
synonym: "(1S)-1-carboxy-2-phenylethanaminium" RELATED [IUPAC]
synonym: "L-phenylalanine cation" RELATED [JCBN]
synonym: "L-phenylalaninium" EXACT IUPAC_NAME [IUPAC]
xref: PMID:21956539 {source="Europe PMC"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32505 ! phenylalaninium
relationship: is_conjugate_acid_of CHEBI:17295 ! L-phenylalanine
relationship: is_enantiomer_of CHEBI:32495 ! D-phenylalaninium
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p+1/t8-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "166.19710" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.08626" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H](Cc1ccccc1)C(O)=O" xsd:string

[Term]
id: CHEBI:32494
name: D-phenylalaninate
namespace: chebi_ontology
def: "The D-enantiomer of phenylalaninate." []
subset: 3_STAR
synonym: "(2R)-2-amino-3-phenylpropanoate" RELATED [IUPAC]
synonym: "D-phenylalaninate" EXACT IUPAC_NAME [IUPAC]
synonym: "D-phenylalanine anion" RELATED [JCBN]
xref: Beilstein:5740552 {source="Beilstein"}
xref: Gmelin:746993 {source="Gmelin"}
is_a: CHEBI:32504 ! phenylalaninate
relationship: is_conjugate_base_of CHEBI:16998 ! D-phenylalanine
relationship: is_enantiomer_of CHEBI:32486 ! L-phenylalaninate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H10NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p-1/t8-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "164.18120" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "164.07170" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H](Cc1ccccc1)C([O-])=O" xsd:string

[Term]
id: CHEBI:32495
name: D-phenylalaninium
namespace: chebi_ontology
def: "An optically active form of phenylalaninium having D-configuration." []
subset: 3_STAR
synonym: "(1R)-1-carboxy-2-phenylethanaminium" RELATED [IUPAC]
synonym: "D-phenylalanine cation" RELATED [JCBN]
synonym: "D-phenylalaninium" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:32505 ! phenylalaninium
relationship: is_conjugate_acid_of CHEBI:16998 ! D-phenylalanine
relationship: is_enantiomer_of CHEBI:32487 ! L-phenylalaninium
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p+1/t8-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "166.19710" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.08626" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H](Cc1ccccc1)C(O)=O" xsd:string

[Term]
id: CHEBI:32504
name: phenylalaninate
namespace: chebi_ontology
def: "An aromatic amino-acid anion that is the conjugate base of phenylalanine, arising from deprotonation of the carboxy group." []
subset: 3_STAR
synonym: "2-amino-3-phenylpropanoate" RELATED [IUPAC]
synonym: "phenylalaninate" EXACT IUPAC_NAME [IUPAC]
synonym: "phenylalanine anion" RELATED [JCBN]
xref: Gmelin:329083 {source="Gmelin"}
is_a: CHEBI:33558 ! alpha-amino-acid anion
is_a: CHEBI:63473 ! aromatic amino-acid anion
relationship: is_conjugate_base_of CHEBI:28044 ! phenylalanine
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H10NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "164.18120" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "164.07170" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(Cc1ccccc1)C([O-])=O" xsd:string

[Term]
id: CHEBI:32505
name: phenylalaninium
namespace: chebi_ontology
def: "An alpha-amino-acid cation that is the conjugate acid of phenylalanine, arising from protonation of the amino group." []
subset: 3_STAR
synonym: "1-carboxy-2-phenylethanaminium" RELATED [IUPAC]
synonym: "phenylalanine cation" RELATED [JCBN]
synonym: "phenylalaninium" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: is_conjugate_acid_of CHEBI:28044 ! phenylalanine
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "166.19710" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.08626" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(Cc1ccccc1)C(O)=O" xsd:string

[Term]
id: CHEBI:32955
name: epoxide
namespace: chebi_ontology
alt_id: CHEBI:13828
alt_id: CHEBI:23930
alt_id: CHEBI:4812
def: "Any cyclic ether in which the oxygen atom forms part of a 3-membered ring." []
subset: 3_STAR
synonym: "Alkene oxide" RELATED [KEGG_COMPOUND]
synonym: "an epoxide" RELATED [UniProt]
synonym: "Epoxide" EXACT [KEGG_COMPOUND]
synonym: "epoxides" EXACT IUPAC_NAME [IUPAC]
synonym: "epoxides" RELATED [ChEBI]
synonym: "Olefin oxide" RELATED [KEGG_COMPOUND]
xref: KEGG:C00722
xref: PMID:10891060 {source="Europe PMC"}
xref: Wikipedia:Epoxide
is_a: CHEBI:37407 ! cyclic ether
relationship: has_parent_hydride CHEBI:27561 ! oxirane
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2OR4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "40.02080" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "39.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C1([*])OC1([*])[*]" xsd:string

[Term]
id: CHEBI:32988
name: amide
namespace: chebi_ontology
alt_id: CHEBI:22473
alt_id: CHEBI:2633
def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3_STAR
synonym: "Amide" EXACT [KEGG_COMPOUND]
synonym: "amides" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00241
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:33118
name: boric acid
namespace: chebi_ontology
alt_id: CHEBI:22911
alt_id: CHEBI:31299
alt_id: CHEBI:41248
subset: 3_STAR
synonym: "[B(OH)3]" RELATED [MolBase]
synonym: "B(OH)3" RELATED [NIST_Chemistry_WebBook]
synonym: "BORIC ACID" EXACT [PDBeChem]
synonym: "Boric acid" EXACT [KEGG_COMPOUND]
synonym: "boric acid" EXACT [IUPAC]
synonym: "boron trihydroxide" RELATED [NIST_Chemistry_WebBook]
synonym: "H3BO3" RELATED [IUPAC]
synonym: "orthoboric acid" RELATED [NIST_Chemistry_WebBook]
synonym: "trihydroxidoboron" EXACT IUPAC_NAME [IUPAC]
xref: BPDB:2136
xref: CAS:10043-35-3 {source="NIST Chemistry WebBook"}
xref: CAS:10043-35-3 {source="ChemIDplus"}
xref: CAS:10043-35-3 {source="KEGG COMPOUND"}
xref: CAS:11113-50-1 {source="ChemIDplus"}
xref: Drug_Central:3035 {source="DrugCentral"}
xref: Gmelin:1585 {source="Gmelin"}
xref: KEGG:C12486
xref: KEGG:D01089
xref: MolBase:1644
xref: PDBeChem:BO3
xref: PPDB:2136
is_a: CHEBI:59765 ! boric acids
relationship: is_conjugate_acid_of CHEBI:29254 ! dihydrogenborate
relationship: RO:0000087 CHEBI:74783 ! has role astringent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "BH3O3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/BH3O3/c2-1(3)4/h2-4H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KGBXLFKZBHKPEV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "61.83302" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.01752" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OB(O[H])O[H]" xsd:string

[Term]
id: CHEBI:33145
name: boron oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "boron oxoacid" EXACT [ChEBI]
synonym: "boron oxoacids" RELATED [ChEBI]
synonym: "oxoacids of boron" RELATED [ChEBI]
is_a: CHEBI:22916 ! boron molecular entity
is_a: CHEBI:24833 ! oxoacid

[Term]
id: CHEBI:33229
name: vitamin (role)
namespace: chebi_ontology
alt_id: CHEBI:10004
alt_id: CHEBI:27305
def: "A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term \"vitamines\" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines." []
subset: 3_STAR
synonym: "vitamin" RELATED [ChEBI]
synonym: "vitamina" RELATED [ChEBI]
synonym: "vitaminas" RELATED [ChEBI]
synonym: "vitamine" RELATED [ChEBI]
synonym: "vitamines" RELATED [ChEBI]
synonym: "vitamins" RELATED [ChEBI]
synonym: "vitaminum" RELATED [ChEBI]
xref: Wikipedia:Vitamin
is_a: CHEBI:27027 ! micronutrient
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:33232
name: application
namespace: chebi_ontology
def: "Intended use of the molecular entity or part thereof by humans." []
subset: 3_STAR
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:33233
name: fundamental particle
namespace: chebi_ontology
def: "A particle not known to have substructure." []
subset: 3_STAR
synonym: "elementary particle" EXACT IUPAC_NAME [IUPAC]
synonym: "elementary particles" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:33238
name: monoatomic entity
namespace: chebi_ontology
def: "A monoatomic entity is a molecular entity consisting of a single atom." []
subset: 3_STAR
synonym: "atomic entity" RELATED [ChEBI]
synonym: "monoatomic entities" RELATED [ChEBI]
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:33240
name: coordination entity
namespace: chebi_ontology
def: "An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands)." []
subset: 3_STAR
synonym: "coordination compounds" RELATED [ChEBI]
synonym: "coordination entities" EXACT IUPAC_NAME [IUPAC]
synonym: "coordination entity" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:33241
name: oxoacid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoacid derivatives" RELATED [ChEBI]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_functional_parent CHEBI:24833 ! oxoacid

[Term]
id: CHEBI:33242
name: inorganic hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic hydrides" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:33245
name: organic fundamental parent
namespace: chebi_ontology
def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." []
subset: 3_STAR
synonym: "organic fundamental parents" RELATED [ChEBI]
synonym: "organic parent hydrides" RELATED [ChEBI]
is_a: CHEBI:37175 ! organic hydride
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33246
name: inorganic group
namespace: chebi_ontology
def: "Any substituent group which does not contain carbon." []
subset: 3_STAR
synonym: "inorganic groups" RELATED [ChEBI]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:33247
name: organic group
namespace: chebi_ontology
def: "Any substituent group or skeleton containing carbon." []
subset: 3_STAR
synonym: "organic groups" RELATED [ChEBI]
is_a: CHEBI:24433 ! group
relationship: is_substituent_group_from CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33248
name: hydrocarbyl group
namespace: chebi_ontology
def: "A univalent group formed by removing a hydrogen atom from a hydrocarbon." []
subset: 3_STAR
synonym: "groupe hydrocarbyle" RELATED [IUPAC]
synonym: "grupo hidrocarbilo" RELATED [IUPAC]
synonym: "grupos hidrocarbilo" RELATED [IUPAC]
synonym: "hydrocarbyl group" EXACT [IUPAC]
synonym: "hydrocarbyl groups" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33249 ! organyl group
relationship: is_substituent_group_from CHEBI:24632 ! hydrocarbon

[Term]
id: CHEBI:33249
name: organyl group
namespace: chebi_ontology
def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." []
subset: 3_STAR
synonym: "groupe organyle" RELATED [IUPAC]
synonym: "grupo organilo" RELATED [IUPAC]
synonym: "grupos organilo" RELATED [IUPAC]
synonym: "organyl group" EXACT IUPAC_NAME [IUPAC]
synonym: "organyl groups" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:51447 ! organic univalent group

[Term]
id: CHEBI:33250
name: atom
namespace: chebi_ontology
alt_id: CHEBI:22671
alt_id: CHEBI:23907
def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." []
subset: 3_STAR
synonym: "atom" EXACT IUPAC_NAME [IUPAC]
synonym: "atome" RELATED [IUPAC]
synonym: "atomo" RELATED [IUPAC]
synonym: "atoms" RELATED [ChEBI]
synonym: "atomus" RELATED [ChEBI]
synonym: "element" RELATED [ChEBI]
synonym: "elements" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity
relationship: BFO:0000051 CHEBI:10545 ! has part electron
relationship: BFO:0000051 CHEBI:33252 ! has part atomic nucleus

[Term]
id: CHEBI:33251
name: monoatomic hydrogen
namespace: chebi_ontology
subset: 3_STAR
synonym: "atomic hydrogen" RELATED [ChEBI]
is_a: CHEBI:33238 ! monoatomic entity
is_a: CHEBI:33260 ! elemental hydrogen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YZCKVEUIGOORGS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "1.00794" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.00783" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]" xsd:string

[Term]
id: CHEBI:33252
name: atomic nucleus
namespace: chebi_ontology
def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." []
subset: 3_STAR
synonym: "Atomkern" RELATED [ChEBI]
synonym: "Kern" RELATED [ChEBI]
synonym: "noyau" RELATED [IUPAC]
synonym: "noyau atomique" RELATED [ChEBI]
synonym: "nuclei" RELATED [ChEBI]
synonym: "nucleo" RELATED [IUPAC]
synonym: "nucleo atomico" RELATED [ChEBI]
synonym: "nucleus" EXACT IUPAC_NAME [IUPAC]
synonym: "nucleus atomi" RELATED [ChEBI]
is_a: CHEBI:36347 ! nuclear particle
relationship: BFO:0000051 CHEBI:33253 ! has part nucleon

[Term]
id: CHEBI:33253
name: nucleon
namespace: chebi_ontology
def: "Heavy nuclear particle: proton or neutron." []
subset: 3_STAR
synonym: "nucleon" EXACT [IUPAC]
synonym: "nucleon" EXACT IUPAC_NAME [IUPAC]
synonym: "nucleons" RELATED [ChEBI]
synonym: "Nukleon" RELATED [ChEBI]
synonym: "Nukleonen" RELATED [ChEBI]
is_a: CHEBI:36339 ! baryon
is_a: CHEBI:36347 ! nuclear particle

[Term]
id: CHEBI:33256
name: primary amide
namespace: chebi_ontology
def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3_STAR
synonym: "primary amide" EXACT [IUPAC]
synonym: "primary amides" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:32988 ! amide

[Term]
id: CHEBI:33259
name: elemental molecular entity
namespace: chebi_ontology
def: "A molecular entity all atoms of which have the same atomic number." []
subset: 3_STAR
synonym: "homoatomic entity" RELATED [ChEBI]
synonym: "homoatomic molecular entities" RELATED [ChEBI]
synonym: "homoatomic molecular entity" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:33260
name: elemental hydrogen
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33259 ! elemental molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity

[Term]
id: CHEBI:33261
name: organosulfur compound
namespace: chebi_ontology
alt_id: CHEBI:23010
alt_id: CHEBI:25714
def: "An organosulfur compound is a compound containing at least one carbon-sulfur bond." []
subset: 3_STAR
synonym: "organosulfur compound" EXACT [ChEBI]
synonym: "organosulfur compounds" RELATED [ChEBI]
xref: Wikipedia:Organosulfur_compounds
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:33273
name: polyatomic anion
namespace: chebi_ontology
def: "An anion consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36358 ! polyatomic ion

[Term]
id: CHEBI:33280
name: molecular messenger
namespace: chebi_ontology
subset: 3_STAR
synonym: "chemical messenger" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:33281
name: antimicrobial agent
namespace: chebi_ontology
alt_id: CHEBI:22582
def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." []
subset: 3_STAR
synonym: "antibiotic" RELATED [ChEBI]
synonym: "antibiotics" RELATED [ChEBI]
synonym: "Antibiotika" RELATED [ChEBI]
synonym: "Antibiotikum" RELATED [ChEBI]
synonym: "antibiotique" RELATED [IUPAC]
synonym: "antimicrobial" RELATED [ChEBI]
synonym: "antimicrobial agents" RELATED [ChEBI]
synonym: "antimicrobials" RELATED [ChEBI]
synonym: "microbicide" RELATED [ChEBI]
synonym: "microbicides" RELATED [ChEBI]
xref: PMID:12964249 {source="Europe PMC"}
xref: PMID:22117953 {source="Europe PMC"}
xref: PMID:22439833 {source="Europe PMC"}
xref: PMID:22849268 {source="Europe PMC"}
xref: PMID:22849276 {source="Europe PMC"}
xref: PMID:22958833 {source="Europe PMC"}
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:33282
name: antibacterial agent
namespace: chebi_ontology
def: "A substance (or active part thereof) that kills or slows the growth of bacteria." []
subset: 3_STAR
synonym: "antibacterial agents" RELATED [ChEBI]
synonym: "antibacterials" RELATED [ChEBI]
synonym: "bactericide" RELATED [ChEBI]
synonym: "bactericides" RELATED [ChEBI]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:33284
name: nutrient
namespace: chebi_ontology
def: "A nutrient is a food component that an organism uses to survive and grow." []
subset: 3_STAR
synonym: "nutrients" RELATED [ChEBI]
is_a: CHEBI:78295 ! food component

[Term]
id: CHEBI:33285
name: heteroorganic entity
namespace: chebi_ontology
def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." []
subset: 3_STAR
synonym: "heteroorganic entities" RELATED [ChEBI]
synonym: "organoelement compounds" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33286
name: agrochemical
namespace: chebi_ontology
def: "An agrochemical is a substance that is used in agriculture or horticulture." []
subset: 3_STAR
synonym: "agrichemical" RELATED [ChEBI]
synonym: "agrichemicals" RELATED [ChEBI]
synonym: "agricultural chemicals" RELATED [ChEBI]
synonym: "agrochemicals" RELATED [ChEBI]
xref: Wikipedia:Agrochemical
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:33287
name: fertilizer
namespace: chebi_ontology
def: "A fertilizer is any substance that is added to soil or water to assist the growth of plants." []
subset: 3_STAR
synonym: "fertiliser" RELATED [ChEBI]
synonym: "fertilizers" RELATED [ChEBI]
is_a: CHEBI:33286 ! agrochemical

[Term]
id: CHEBI:33295
name: diagnostic agent
namespace: chebi_ontology
def: "A substance administered to aid diagnosis of a disease." []
subset: 3_STAR
synonym: "diagnostic aid" RELATED [ChEBI]
is_a: CHEBI:52217 ! pharmaceutical

[Term]
id: CHEBI:33296
name: alkali metal molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms of an alkali metal." []
subset: 3_STAR
synonym: "alkali metal molecular entities" RELATED [ChEBI]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: BFO:0000051 CHEBI:22314 ! has part alkali metal atom

[Term]
id: CHEBI:33300
name: pnictogen
namespace: chebi_ontology
def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." []
subset: 3_STAR
synonym: "group 15 elements" RELATED [ChEBI]
synonym: "group V elements" RELATED [ChEBI]
synonym: "nitrogenoideos" RELATED [ChEBI]
synonym: "nitrogenoides" RELATED [ChEBI]
synonym: "pnictogene" RELATED [ChEBI]
synonym: "pnictogenes" RELATED [ChEBI]
synonym: "pnictogens" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33302
name: pnictogen molecular entity
namespace: chebi_ontology
def: "A p-block molecular entity containing any pnictogen." []
subset: 3_STAR
synonym: "pnictogen molecular entities" RELATED [ChEBI]
synonym: "pnictogen molecular entity" EXACT [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:33300 ! has part pnictogen

[Term]
id: CHEBI:33303
name: chalcogen
namespace: chebi_ontology
def: "Any p-block element belonging to the group 16 family of the periodic table." []
subset: 3_STAR
synonym: "anfigeno" RELATED [ChEBI]
synonym: "anfigenos" RELATED [ChEBI]
synonym: "calcogeno" RELATED [ChEBI]
synonym: "calcogenos" RELATED [ChEBI]
synonym: "chalcogen" EXACT IUPAC_NAME [IUPAC]
synonym: "chalcogene" RELATED [ChEBI]
synonym: "chalcogenes" RELATED [ChEBI]
synonym: "chalcogens" EXACT IUPAC_NAME [IUPAC]
synonym: "Chalkogen" RELATED [ChEBI]
synonym: "Chalkogene" RELATED [ChEBI]
synonym: "group 16 elements" RELATED [ChEBI]
synonym: "group VI elements" RELATED [ChEBI]
xref: PMID:17084588 {source="Europe PMC"}
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33304
name: chalcogen molecular entity
namespace: chebi_ontology
def: "Any p-block molecular entity containing a chalcogen." []
subset: 3_STAR
synonym: "chalcogen compounds" RELATED [ChEBI]
synonym: "chalcogen molecular entities" RELATED [ChEBI]
synonym: "chalcogen molecular entity" EXACT [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:33303 ! has part chalcogen

[Term]
id: CHEBI:33306
name: carbon group element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbon group element" RELATED [ChEBI]
synonym: "carbon group elements" RELATED [ChEBI]
synonym: "carbonoides" RELATED [ChEBI]
synonym: "cristallogene" RELATED [ChEBI]
synonym: "cristallogenes" RELATED [ChEBI]
synonym: "group 14 elements" EXACT IUPAC_NAME [IUPAC]
synonym: "group IV elements" RELATED [ChEBI]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33308
name: carboxylic ester
namespace: chebi_ontology
alt_id: CHEBI:13204
alt_id: CHEBI:23028
alt_id: CHEBI:3408
def: "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." []
subset: 3_STAR
synonym: "a carboxylic ester" RELATED [UniProt]
synonym: "carboxylic acid esters" RELATED [ChEBI]
synonym: "Carboxylic ester" EXACT [KEGG_COMPOUND]
synonym: "carboxylic esters" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C02391
xref: Wikipedia:Ester
is_a: CHEBI:35701 ! ester
is_a: CHEBI:36586 ! carbonyl compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)O[*]" xsd:string

[Term]
id: CHEBI:33317
name: boron group element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "boron group element" RELATED [ChEBI]
synonym: "boron group elements" RELATED [ChEBI]
synonym: "Element der Borgruppe" RELATED [ChEBI]
synonym: "group 13 elements" EXACT IUPAC_NAME [IUPAC]
synonym: "group III elements" RELATED [ChEBI]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33318
name: main group element atom
namespace: chebi_ontology
def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." []
subset: 3_STAR
synonym: "Hauptgruppenelement" RELATED [ChEBI]
synonym: "Hauptgruppenelemente" RELATED [ChEBI]
synonym: "main group element" RELATED [ChEBI]
synonym: "main group elements" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33338
name: aryl group
namespace: chebi_ontology
def: "A group derived from an arene by removal of a hydrogen atom from a ring carbon atom." []
subset: 3_STAR
synonym: "aryl groups" EXACT IUPAC_NAME [IUPAC]
synonym: "Arylgruppe" RELATED [ChEBI]
synonym: "groupe aryle" RELATED [IUPAC]
synonym: "grupos arilo" RELATED [IUPAC]
is_a: CHEBI:33248 ! hydrocarbyl group
relationship: is_substituent_group_from CHEBI:33658 ! arene

[Term]
id: CHEBI:33362
name: nickel group element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "group 10 elements" EXACT IUPAC_NAME [IUPAC]
synonym: "nickel group element" RELATED [ChEBI]
synonym: "nickel group elements" RELATED [ChEBI]
is_a: CHEBI:33561 ! d-block element atom

[Term]
id: CHEBI:33364
name: platinum
namespace: chebi_ontology
subset: 3_STAR
synonym: "78Pt" RELATED [IUPAC]
synonym: "Platin" RELATED [ChEBI]
synonym: "platine" RELATED [ChEBI]
synonym: "platino" RELATED [ChEBI]
synonym: "platinum" EXACT IUPAC_NAME [IUPAC]
synonym: "Pt" RELATED [IUPAC]
xref: CAS:7440-06-4 {source="NIST Chemistry WebBook"}
xref: CAS:7440-06-4 {source="ChemIDplus"}
xref: WebElements:Pt
is_a: CHEBI:33362 ! nickel group element atom
is_a: CHEBI:33365 ! platinum group metal atom
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Pt" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Pt" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BASFCYQUMIYNBI-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "195.078" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "194.96479" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Pt]" xsd:string

[Term]
id: CHEBI:33365
name: platinum group metal atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "PGM" RELATED [ChEBI]
synonym: "Platinmetalle" RELATED [ChEBI]
synonym: "platinoid" RELATED [ChEBI]
synonym: "Platinoide" RELATED [ChEBI]
synonym: "platinum group metal" RELATED [ChEBI]
synonym: "platinum group metals" RELATED [ChEBI]
synonym: "platinum metals" RELATED [ChEBI]
is_a: CHEBI:27081 ! transition element atom

[Term]
id: CHEBI:33366
name: copper group element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "coinage metals" RELATED [ChEBI]
synonym: "copper group element" RELATED [ChEBI]
synonym: "copper group elements" RELATED [ChEBI]
synonym: "group 11 elements" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33561 ! d-block element atom

[Term]
id: CHEBI:33402
name: sulfur oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoacids of sulfur" RELATED [ChEBI]
synonym: "sulfur oxoacids" RELATED [ChEBI]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33484 ! chalcogen oxoacid

[Term]
id: CHEBI:33405
name: hydracid
namespace: chebi_ontology
def: "A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." []
subset: 3_STAR
synonym: "hydracid" EXACT IUPAC_NAME [IUPAC]
synonym: "hydracids" RELATED [ChEBI]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33608 ! hydrogen molecular entity
relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid

[Term]
id: CHEBI:33408
name: pnictogen oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "pnictogen oxoacids" RELATED [ChEBI]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid

[Term]
id: CHEBI:33424
name: sulfur oxoacid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfur oxoacid derivative" EXACT [ChEBI]
synonym: "sulfur oxoacid derivatives" RELATED [ChEBI]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33241 ! oxoacid derivative

[Term]
id: CHEBI:33429
name: monoatomic monoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic monoanions" RELATED [ChEBI]
is_a: CHEBI:23905 ! monoatomic anion
is_a: CHEBI:36830 ! monoanion
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*-]" xsd:string

[Term]
id: CHEBI:33431
name: elemental chlorine
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:23117 ! chlorine molecular entity
is_a: CHEBI:33434 ! elemental halogen

[Term]
id: CHEBI:33432
name: monoatomic chlorine
namespace: chebi_ontology
subset: 3_STAR
synonym: "atomic chlorine" RELATED [ChEBI]
is_a: CHEBI:33431 ! elemental chlorine
is_a: CHEBI:33433 ! monoatomic halogen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "35.453" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96885" xsd:string

[Term]
id: CHEBI:33433
name: monoatomic halogen
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic halogens" RELATED [ChEBI]
is_a: CHEBI:33238 ! monoatomic entity

[Term]
id: CHEBI:33434
name: elemental halogen
namespace: chebi_ontology
subset: 3_STAR
synonym: "elemental halogen" EXACT [ChEBI]
synonym: "elemental halogens" RELATED [ChEBI]
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:33452
name: benzylic group
namespace: chebi_ontology
def: "Arylmethyl groups and derivatives formed by substitution: ArCR2-." []
subset: 3_STAR
synonym: "benzylic group" EXACT [IUPAC]
synonym: "benzylic groups" EXACT IUPAC_NAME [IUPAC]
synonym: "benzylic groups" RELATED [ChEBI]
synonym: "groupe benzylique" RELATED [IUPAC]
is_a: CHEBI:33249 ! organyl group

[Term]
id: CHEBI:33457
name: phosphorus oxoacid
namespace: chebi_ontology
def: "A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons." []
subset: 3_STAR
synonym: "oxoacids of phosphorus" RELATED [ChEBI]
synonym: "Oxosaeure des Phosphors" RELATED [ChEBI]
synonym: "phosphorus oxoacid" EXACT [ChEBI]
synonym: "phosphorus oxoacids" RELATED [ChEBI]
is_a: CHEBI:33408 ! pnictogen oxoacid
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives

[Term]
id: CHEBI:33459
name: pnictogen oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "pnictogen oxoanion" EXACT [ChEBI]
synonym: "pnictogen oxoanions" RELATED [ChEBI]
is_a: CHEBI:33302 ! pnictogen molecular entity
is_a: CHEBI:35406 ! oxoanion

[Term]
id: CHEBI:33461
name: phosphorus oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoanions of phosphorus" RELATED [ChEBI]
synonym: "phosphorus oxoanion" EXACT [ChEBI]
synonym: "phosphorus oxoanions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33459 ! pnictogen oxoanion

[Term]
id: CHEBI:33482
name: sulfur oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoanions of sulfur" RELATED [ChEBI]
synonym: "sulfur oxoanion" EXACT [ChEBI]
synonym: "sulfur oxoanions" RELATED [ChEBI]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33485 ! chalcogen oxoanion

[Term]
id: CHEBI:33484
name: chalcogen oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "chalcogen oxoacid" EXACT [ChEBI]
synonym: "chalcogen oxoacids" RELATED [ChEBI]
is_a: CHEBI:24833 ! oxoacid
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid

[Term]
id: CHEBI:33485
name: chalcogen oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "chalcogen oxoanion" EXACT [ChEBI]
synonym: "chalcogen oxoanions" RELATED [ChEBI]
is_a: CHEBI:35406 ! oxoanion

[Term]
id: CHEBI:33497
name: transition element molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms of a transition element." []
subset: 3_STAR
synonym: "transition element molecular entities" RELATED [ChEBI]
synonym: "transition metal molecular entity" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity
relationship: BFO:0000051 CHEBI:27081 ! has part transition element atom

[Term]
id: CHEBI:33504
name: alkali metal cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "alkali metal cations" RELATED [ChEBI]
is_a: CHEBI:25213 ! metal cation

[Term]
id: CHEBI:33515
name: transition element cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "transition element cations" RELATED [ChEBI]
synonym: "transition metal cation" RELATED [ChEBI]
is_a: CHEBI:25213 ! metal cation

[Term]
id: CHEBI:33521
name: metal atom
namespace: chebi_ontology
alt_id: CHEBI:25217
alt_id: CHEBI:6788
def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." []
subset: 3_STAR
synonym: "elemental metal" RELATED [ChEBI]
synonym: "elemental metals" RELATED [ChEBI]
synonym: "metal element" RELATED [ChEBI]
synonym: "metal elements" RELATED [ChEBI]
synonym: "metals" RELATED [ChEBI]
xref: KEGG:C00050
xref: PMID:21784043 {source="Europe PMC"}
xref: Wikipedia:Metal
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33543
name: sulfonate
namespace: chebi_ontology
def: "The sulfur oxoanion formed by deprotonation of sulfonic acid." []
subset: 3_STAR
synonym: "[SHO3](-)" RELATED [IUPAC]
synonym: "hydridotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "SHO3(-)" RELATED [IUPAC]
synonym: "sulfonates" RELATED [ChEBI]
xref: Gmelin:971569 {source="Gmelin"}
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: is_conjugate_base_of CHEBI:29214 ! sulfonic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96519" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:33551
name: organosulfonic acid
namespace: chebi_ontology
def: "An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon." []
subset: 3_STAR
synonym: "organosulfonic acids" RELATED [ChEBI]
synonym: "sulfonic acids" RELATED [ChEBI]
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:33552 ! sulfonic acid derivative
is_a: CHEBI:64709 ! organic acid
relationship: BFO:0000051 CHEBI:29922 ! has part sulfo group
relationship: BFO:0000051 CHEBI:33249 ! has part organyl group
relationship: is_conjugate_acid_of CHEBI:33554 ! organosulfonate oxoanion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07100" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96464" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS([*])(=O)=O" xsd:string

[Term]
id: CHEBI:33552
name: sulfonic acid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "derivatives of sulfonic acid" RELATED [ChEBI]
synonym: "sulfonic acid derivative" EXACT [ChEBI]
synonym: "sulfonic acid derivatives" RELATED [ChEBI]
is_a: CHEBI:33424 ! sulfur oxoacid derivative
relationship: has_functional_parent CHEBI:29214 ! sulfonic acid

[Term]
id: CHEBI:33554
name: organosulfonate oxoanion
namespace: chebi_ontology
def: "An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid." []
subset: 3_STAR
synonym: "organosulfonate" RELATED [ChEBI]
synonym: "organosulfonate oxoanions" RELATED [ChEBI]
synonym: "organosulfonates" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
relationship: has_functional_parent CHEBI:33543 ! sulfonate
relationship: is_conjugate_base_of CHEBI:33551 ! organosulfonic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O3SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "80.064" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.95681" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*S([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:33555
name: arenesulfonic acid
namespace: chebi_ontology
def: "Organic derivatives of sulfonic acid in which the sulfo group is linked directly to carbon of an aryl group." []
subset: 3_STAR
synonym: "arenesulfonic acids" RELATED [ChEBI]
synonym: "arylsulfonic acid" RELATED [ChEBI]
synonym: "arylsulfonic acids" RELATED [ChEBI]
is_a: CHEBI:33551 ! organosulfonic acid
relationship: BFO:0000051 CHEBI:33338 ! has part aryl group
relationship: is_conjugate_acid_of CHEBI:22713 ! arenesulfonate oxoanion

[Term]
id: CHEBI:33558
name: alpha-amino-acid anion
namespace: chebi_ontology
def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." []
subset: 3_STAR
synonym: "alpha-amino acid anions" RELATED [ChEBI]
synonym: "alpha-amino-acid anion" EXACT [ChEBI]
synonym: "alpha-amino-acid anions" RELATED [ChEBI]
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid

[Term]
id: CHEBI:33559
name: s-block element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "s-block element" RELATED [ChEBI]
synonym: "s-block elements" RELATED [ChEBI]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33560
name: p-block element atom
namespace: chebi_ontology
def: "Any main group element atom belonging to the p-block of the periodic table." []
subset: 3_STAR
synonym: "p-block element" RELATED [ChEBI]
synonym: "p-block elements" RELATED [ChEBI]
is_a: CHEBI:33318 ! main group element atom

[Term]
id: CHEBI:33561
name: d-block element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "d-block element" RELATED [ChEBI]
synonym: "d-block elements" RELATED [ChEBI]
is_a: CHEBI:27081 ! transition element atom

[Term]
id: CHEBI:33570
name: benzenediols
namespace: chebi_ontology
alt_id: CHEBI:22705
alt_id: CHEBI:22711
subset: 3_STAR
is_a: CHEBI:33853 ! phenols

[Term]
id: CHEBI:33575
name: carboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:13428
alt_id: CHEBI:13627
alt_id: CHEBI:23027
def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." []
subset: 3_STAR
synonym: "acide carboxylique" RELATED [IUPAC]
synonym: "acides carboxyliques" RELATED [IUPAC]
synonym: "acido carboxilico" RELATED [IUPAC]
synonym: "acidos carboxilicos" RELATED [IUPAC]
synonym: "Carbonsaeure" RELATED [ChEBI]
synonym: "Carbonsaeuren" RELATED [ChEBI]
synonym: "carboxylic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxylic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "Karbonsaeure" RELATED [ChEBI]
synonym: "RC(=O)OH" RELATED [IUPAC]
xref: PMID:17147560 {source="Europe PMC"}
xref: PMID:18433345 {source="Europe PMC"}
xref: Wikipedia:Carboxylic_acid
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36586 ! carbonyl compound
is_a: CHEBI:64709 ! organic acid
relationship: BFO:0000051 CHEBI:46883 ! has part carboxy group
relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01740" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string

[Term]
id: CHEBI:33576
name: sulfur-containing carboxylic acid
namespace: chebi_ontology
def: "Any carboxylic acid having a sulfur substituent." []
subset: 3_STAR
synonym: "S-containing carboxylic acid" RELATED [ChEBI]
synonym: "S-containing carboxylic acids" RELATED [ChEBI]
synonym: "sulfur-containing carboxylic acids" RELATED [ChEBI]
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:33575 ! carboxylic acid

[Term]
id: CHEBI:33579
name: main group molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." []
subset: 3_STAR
synonym: "main group compounds" RELATED [ChEBI]
synonym: "main group molecular entities" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity
relationship: BFO:0000051 CHEBI:33318 ! has part main group element atom

[Term]
id: CHEBI:33581
name: boron group molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "boron group molecular entities" RELATED [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:33317 ! has part boron group element atom

[Term]
id: CHEBI:33582
name: carbon group molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbon group molecular entities" RELATED [ChEBI]
synonym: "carbon group molecular entity" EXACT [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:33306 ! has part carbon group element atom

[Term]
id: CHEBI:33595
name: cyclic compound
namespace: chebi_ontology
def: "Any molecule that consists of a series of atoms joined together to form a ring." []
subset: 3_STAR
synonym: "cyclic compounds" RELATED [ChEBI]
xref: Wikipedia:Cyclic_compound
is_a: CHEBI:25367 ! molecule

[Term]
id: CHEBI:33597
name: homocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of the same element only." []
subset: 3_STAR
synonym: "homocyclic compound" EXACT IUPAC_NAME [IUPAC]
synonym: "homocyclic compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "isocyclic compounds" RELATED [IUPAC]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33598
name: carbocyclic compound
namespace: chebi_ontology
def: "A homocyclic compound in which all of the ring members are carbon atoms." []
subset: 3_STAR
synonym: "carbocycle" RELATED [ChEBI]
synonym: "carbocyclic compound" EXACT IUPAC_NAME [IUPAC]
synonym: "carbocyclic compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33597 ! homocyclic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:33608
name: hydrogen molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "hydrogen compounds" RELATED [ChEBI]
synonym: "hydrogen molecular entities" RELATED [ChEBI]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: BFO:0000051 CHEBI:49637 ! has part hydrogen atom

[Term]
id: CHEBI:33619
name: boron oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "boron oxoanion" EXACT [ChEBI]
synonym: "boron oxoanions" RELATED [ChEBI]
is_a: CHEBI:22916 ! boron molecular entity
is_a: CHEBI:35406 ! oxoanion

[Term]
id: CHEBI:33635
name: polycyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "polycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33636
name: bicyclic compound
namespace: chebi_ontology
def: "A molecule that features two fused rings." []
subset: 3_STAR
synonym: "bicyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33637
name: ortho-fused compound
namespace: chebi_ontology
def: "A polycyclic compound in which two rings have two, and only two, atoms in common. Such compounds have n common faces and 2n common atoms." []
subset: 3_STAR
synonym: "ortho-fused compounds" RELATED [ChEBI]
synonym: "ortho-fused polycyclic compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:35293 ! fused compound

[Term]
id: CHEBI:33639
name: ortho- and peri-fused compound
namespace: chebi_ontology
def: "A polycyclic compound in which one ring contains two, and only two, atoms in common with each of two or more rings of a contiguous series of rings. Such compounds have n common faces and less than 2n common atoms." []
subset: 3_STAR
synonym: "ortho- and peri-fused compounds" RELATED [ChEBI]
synonym: "ortho- and peri-fused polycyclic compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:35293 ! fused compound

[Term]
id: CHEBI:33653
name: aliphatic compound
namespace: chebi_ontology
def: "Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds." []
subset: 3_STAR
synonym: "aliphatic compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33655
name: aromatic compound
namespace: chebi_ontology
def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." []
subset: 3_STAR
synonym: "aromatic compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "aromatic molecular entity" EXACT IUPAC_NAME [IUPAC]
synonym: "aromatics" RELATED [ChEBI]
synonym: "aromatische Verbindungen" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33658
name: arene
namespace: chebi_ontology
def: "Any monocyclic or polycyclic aromatic hydrocarbon." []
subset: 3_STAR
synonym: "arene" EXACT IUPAC_NAME [IUPAC]
synonym: "arenes" EXACT IUPAC_NAME [IUPAC]
synonym: "aromatic hydrocarbons" RELATED [IUPAC]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33663 ! cyclic hydrocarbon

[Term]
id: CHEBI:33659
name: organic aromatic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic aromatic compounds" RELATED [ChEBI]
is_a: CHEBI:33655 ! aromatic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:33661
name: monocyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "monocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33662
name: annulene
namespace: chebi_ontology
def: "A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms." []
subset: 3_STAR
synonym: "annulene" EXACT IUPAC_NAME [IUPAC]
synonym: "annulenes" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33664 ! monocyclic hydrocarbon

[Term]
id: CHEBI:33663
name: cyclic hydrocarbon
namespace: chebi_ontology
subset: 3_STAR
synonym: "cyclic hydrocarbon" EXACT [ChEBI]
synonym: "cyclic hydrocarbons" RELATED [ChEBI]
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:33598 ! carbocyclic compound

[Term]
id: CHEBI:33664
name: monocyclic hydrocarbon
namespace: chebi_ontology
subset: 3_STAR
synonym: "monocyclic hydrocarbon" EXACT [ChEBI]
synonym: "monocyclic hydrocarbons" EXACT IUPAC_NAME [IUPAC]
synonym: "monocyclic hydrocarbons" RELATED [ChEBI]
is_a: CHEBI:33663 ! cyclic hydrocarbon

[Term]
id: CHEBI:33666
name: polycyclic hydrocarbon
namespace: chebi_ontology
subset: 3_STAR
synonym: "polycyclic hydrocarbon" EXACT IUPAC_NAME [IUPAC]
synonym: "polycyclic hydrocarbons" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33663 ! cyclic hydrocarbon
is_a: CHEBI:35294 ! carbopolycyclic compound

[Term]
id: CHEBI:33670
name: heteromonocyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "heteromonocyclic compound" EXACT IUPAC_NAME [IUPAC]
synonym: "heteromonocyclic compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33661 ! monocyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33671
name: heteropolycyclic compound
namespace: chebi_ontology
def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." []
subset: 3_STAR
synonym: "heteropolycyclic compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "polyheterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33672
name: heterobicyclic compound
namespace: chebi_ontology
def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." []
subset: 3_STAR
synonym: "heterobicyclic compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33636 ! bicyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33674
name: s-block molecular entity
namespace: chebi_ontology
def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." []
subset: 3_STAR
synonym: "s-block compounds" RELATED [ChEBI]
synonym: "s-block molecular entities" RELATED [ChEBI]
synonym: "s-block molecular entity" EXACT [ChEBI]
is_a: CHEBI:33579 ! main group molecular entity
relationship: BFO:0000051 CHEBI:33559 ! has part s-block element atom

[Term]
id: CHEBI:33675
name: p-block molecular entity
namespace: chebi_ontology
def: "A main group molecular entity that contains one or more atoms of a p-block element." []
subset: 3_STAR
synonym: "p-block compounds" RELATED [ChEBI]
synonym: "p-block molecular entities" RELATED [ChEBI]
synonym: "p-block molecular entitiy" RELATED [ChEBI]
is_a: CHEBI:33579 ! main group molecular entity
relationship: BFO:0000051 CHEBI:33560 ! has part p-block element atom

[Term]
id: CHEBI:33676
name: d-block molecular entity
namespace: chebi_ontology
def: "A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element." []
subset: 3_STAR
synonym: "d-block compounds" RELATED [ChEBI]
synonym: "d-block molecular entities" RELATED [ChEBI]
synonym: "d-block molecular entity" EXACT [ChEBI]
is_a: CHEBI:33497 ! transition element molecular entity
relationship: BFO:0000051 CHEBI:33561 ! has part d-block element atom

[Term]
id: CHEBI:33692
name: hydrides
namespace: chebi_ontology
def: "Hydrides are chemical compounds of hydrogen with other chemical elements." []
subset: 3_STAR
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:33694
name: biomacromolecule
namespace: chebi_ontology
def: "A macromolecule formed by a living organism." []
subset: 3_STAR
synonym: "biomacromolecules" RELATED [ChEBI]
synonym: "biopolymer" EXACT IUPAC_NAME [IUPAC]
synonym: "Biopolymere" RELATED [ChEBI]
synonym: "biopolymers" RELATED [ChEBI]
is_a: CHEBI:33839 ! macromolecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33695
name: information biomacromolecule
namespace: chebi_ontology
subset: 3_STAR
synonym: "genetically encoded biomacromolecules" RELATED [ChEBI]
synonym: "genetically encoded biopolymers" RELATED [ChEBI]
synonym: "information biomacromolecules" RELATED [ChEBI]
synonym: "information biopolymers" RELATED [ChEBI]
synonym: "information macromolecule" RELATED [ChEBI]
synonym: "information macromolecules" RELATED [ChEBI]
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:33696
name: nucleic acid
namespace: chebi_ontology
def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." []
subset: 3_STAR
synonym: "acide nucleique" RELATED [ChEBI]
synonym: "acides nucleiques" RELATED [ChEBI]
synonym: "acido nucleico" RELATED [ChEBI]
synonym: "acidos nucleicos" RELATED [ChEBI]
synonym: "NA" RELATED [ChEBI]
synonym: "nucleic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "Nukleinsaeure" RELATED [ChEBI]
synonym: "Nukleinsaeuren" RELATED [ChEBI]
is_a: CHEBI:15986 ! polynucleotide
relationship: BFO:0000051 CHEBI:33791 ! has part canonical nucleoside residue
relationship: BFO:0000051 CHEBI:50297 ! has part canonical nucleotide residue

[Term]
id: CHEBI:33702
name: polyatomic cation
namespace: chebi_ontology
def: "A cation consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic cations" RELATED [ChEBI]
is_a: CHEBI:36358 ! polyatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:33703
name: amino-acid cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "amino acid cation" RELATED [ChEBI]
synonym: "amino-acid cation" EXACT [ChEBI]
synonym: "amino-acid cations" RELATED [ChEBI]
is_a: CHEBI:33702 ! polyatomic cation

[Term]
id: CHEBI:33704
name: alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:10208
alt_id: CHEBI:13779
alt_id: CHEBI:22442
alt_id: CHEBI:2642
def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." []
subset: 3_STAR
synonym: "alpha-amino acid" EXACT IUPAC_NAME [IUPAC]
synonym: "alpha-amino acids" RELATED [JCBN]
synonym: "alpha-amino acids" RELATED [ChEBI]
synonym: "alpha-amino carboxylic acids" RELATED [IUPAC]
synonym: "Amino acid" RELATED [KEGG_COMPOUND]
synonym: "Amino acids" RELATED [KEGG_COMPOUND]
xref: KEGG:C00045
xref: KEGG:C05167
is_a: CHEBI:33709 ! amino acid
relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion
relationship: is_tautomer_of CHEBI:78608 ! alpha-amino acid zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([*])C(O)=O" xsd:string

[Term]
id: CHEBI:33708
name: amino-acid residue
namespace: chebi_ontology
def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." []
subset: 3_STAR
synonym: "amino acid residue" RELATED [ChEBI]
synonym: "amino-acid residue" EXACT IUPAC_NAME [IUPAC]
synonym: "amino-acid residues" RELATED [JCBN]
is_a: CHEBI:33247 ! organic group
relationship: is_substituent_group_from CHEBI:33709 ! amino acid

[Term]
id: CHEBI:33709
name: amino acid
namespace: chebi_ontology
alt_id: CHEBI:13815
alt_id: CHEBI:22477
def: "A carboxylic acid containing one or more amino groups." []
subset: 3_STAR
synonym: "amino acids" RELATED [ChEBI]
synonym: "Aminocarbonsaeure" RELATED [ChEBI]
synonym: "Aminokarbonsaeure" RELATED [ChEBI]
synonym: "Aminosaeure" RELATED [ChEBI]
xref: Wikipedia:Amino_acid
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:50047 ! organic amino compound
relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion

[Term]
id: CHEBI:33719
name: alpha-amino-acid cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "alpha-amino acid cations" RELATED [ChEBI]
synonym: "alpha-amino-acid cation" EXACT [ChEBI]
synonym: "alpha-amino-acid cations" RELATED [ChEBI]
is_a: CHEBI:33703 ! amino-acid cation

[Term]
id: CHEBI:33745
name: copper group molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "copper group molecular entities" RELATED [ChEBI]
synonym: "copper group molecular entity" EXACT [ChEBI]
is_a: CHEBI:33676 ! d-block molecular entity
relationship: BFO:0000051 CHEBI:33366 ! has part copper group element atom

[Term]
id: CHEBI:33747
name: nickel group molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "nickel group molecular entities" RELATED [ChEBI]
synonym: "nickel group molecular entity" EXACT [ChEBI]
is_a: CHEBI:33676 ! d-block molecular entity
relationship: BFO:0000051 CHEBI:33362 ! has part nickel group element atom

[Term]
id: CHEBI:33749
name: platinum molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "platinum compounds" RELATED [ChEBI]
synonym: "platinum molecular entities" RELATED [ChEBI]
synonym: "platinum molecular entity" EXACT [ChEBI]
is_a: CHEBI:33747 ! nickel group molecular entity
relationship: BFO:0000051 CHEBI:33364 ! has part platinum

[Term]
id: CHEBI:33791
name: canonical nucleoside residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical nucleoside residues" RELATED [ChEBI]
synonym: "common nucleoside residues" RELATED [CBN]
synonym: "nucleoside residue" RELATED [CBN]
synonym: "standard nucleoside residues" RELATED [ChEBI]
is_a: CHEBI:50320 ! nucleoside residue

[Term]
id: CHEBI:33793
name: canonical deoxyribonucleoside residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical deoxyribonucleoside residues" RELATED [ChEBI]
synonym: "common 2'-deoxyribonucleoside residue" RELATED [CBN]
synonym: "common 2'-deoxyribonucleoside residues" RELATED [CBN]
synonym: "dN" RELATED [CBN]
synonym: "dNuc" RELATED [CBN]
synonym: "standard deoxyribonucleoside residues" RELATED [ChEBI]
is_a: CHEBI:33791 ! canonical nucleoside residue

[Term]
id: CHEBI:33822
name: organic hydroxy compound
namespace: chebi_ontology
alt_id: CHEBI:64710
def: "An organic compound having at least one hydroxy group attached to a carbon atom." []
subset: 3_STAR
synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "organic alcohol" RELATED [ChEBI]
synonym: "organic hydroxy compounds" RELATED [ChEBI]
is_a: CHEBI:24651 ! hydroxides
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33832
name: organic cyclic compound
namespace: chebi_ontology
def: "Any organic molecule that consists of atoms connected in the form of a ring." []
subset: 3_STAR
synonym: "organic cyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:33833
name: heteroarene
namespace: chebi_ontology
def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." []
subset: 3_STAR
synonym: "hetarenes" RELATED [IUPAC]
synonym: "heteroarenes" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:33836
name: benzenoid aromatic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "benzenoid aromatic compounds" RELATED [ChEBI]
synonym: "benzenoid compound" RELATED [ChEBI]
is_a: CHEBI:33598 ! carbocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:33838
name: nucleoside
namespace: chebi_ontology
alt_id: CHEBI:13661
alt_id: CHEBI:25611
alt_id: CHEBI:7647
def: "An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents." []
subset: 3_STAR
synonym: "a nucleoside" RELATED [UniProt]
synonym: "Nucleoside" EXACT [KEGG_COMPOUND]
synonym: "nucleosides" EXACT IUPAC_NAME [IUPAC]
synonym: "nucleosides" RELATED [ChEBI]
xref: KEGG:C00801
xref: Wikipedia:Nucleoside
is_a: CHEBI:21731 ! N-glycosyl compound
is_a: CHEBI:26912 ! oxolanes
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8O3R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "116.115" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.04734" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H]1([C@H]([C@@H](*)[C@@H](O1)*)O)CO" xsd:string

[Term]
id: CHEBI:33839
name: macromolecule
namespace: chebi_ontology
def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
subset: 3_STAR
synonym: "macromolecule" EXACT IUPAC_NAME [IUPAC]
synonym: "macromolecules" RELATED [ChEBI]
synonym: "polymer" RELATED [ChEBI]
synonym: "polymer molecule" RELATED [IUPAC]
synonym: "polymers" RELATED [ChEBI]
xref: Wikipedia:Macromolecule
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:33842
name: aromatic annulene
namespace: chebi_ontology
subset: 3_STAR
synonym: "aromatic annulenes" RELATED [ChEBI]
is_a: CHEBI:33662 ! annulene
is_a: CHEBI:33847 ! monocyclic arene

[Term]
id: CHEBI:33847
name: monocyclic arene
namespace: chebi_ontology
def: "A monocyclic aromatic hydrocarbon." []
subset: 3_STAR
synonym: "monocyclic arenes" RELATED [ChEBI]
is_a: CHEBI:33658 ! arene

[Term]
id: CHEBI:33848
name: polycyclic arene
namespace: chebi_ontology
def: "A polycyclic aromatic hydrocarbon." []
subset: 3_STAR
synonym: "PAH" RELATED [ChEBI]
synonym: "PAHs" RELATED [ChEBI]
synonym: "polycyclic arenes" RELATED [ChEBI]
synonym: "polycyclic aromatic hydrocarbons" RELATED [ChEBI]
xref: PMID:15198916 {source="Europe PMC"}
xref: PMID:25679824 {source="Europe PMC"}
xref: Wikipedia:Polycyclic_aromatic_hydrocarbon
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33658 ! arene
is_a: CHEBI:33666 ! polycyclic hydrocarbon
relationship: RO:0000087 CHEBI:138015 ! has role endocrine disruptor
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent

[Term]
id: CHEBI:33853
name: phenols
namespace: chebi_ontology
alt_id: CHEBI:13664
alt_id: CHEBI:13825
alt_id: CHEBI:25969
alt_id: CHEBI:2857
def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." []
subset: 3_STAR
synonym: "a phenol" RELATED [UniProt]
synonym: "arenols" RELATED [IUPAC]
synonym: "Aryl alcohol" RELATED [KEGG_COMPOUND]
synonym: "phenols" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C15584
xref: MetaCyc:Phenols
xref: Wikipedia:Phenols
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33822 ! organic hydroxy compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6HOR5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "89.072" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.00274" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=C(C(=C(C(=C1*)*)*)*)*)O" xsd:string

[Term]
id: CHEBI:33856
name: aromatic amino acid
namespace: chebi_ontology
alt_id: CHEBI:13820
alt_id: CHEBI:22623
alt_id: CHEBI:2835
def: "An amino acid whose structure includes an aromatic ring." []
subset: 3_STAR
synonym: "Aromatic amino acid" EXACT [KEGG_COMPOUND]
synonym: "aromatic amino acids" RELATED [ChEBI]
xref: KEGG:C01021
xref: Wikipedia:Aromatic_amino_acid
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33709 ! amino acid
relationship: is_conjugate_acid_of CHEBI:63473 ! aromatic amino-acid anion
relationship: is_tautomer_of CHEBI:76042 ! aromatic amino-acid zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "88.085" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string

[Term]
id: CHEBI:33859
name: aromatic carboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:13817
alt_id: CHEBI:13821
alt_id: CHEBI:2830
def: "Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring." []
subset: 3_STAR
synonym: "aromatic carboxylic acids" RELATED [ChEBI]
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:33659 ! organic aromatic compound
relationship: is_conjugate_acid_of CHEBI:91007 ! aromatic carboxylate

[Term]
id: CHEBI:33860
name: aromatic amine
namespace: chebi_ontology
alt_id: CHEBI:13827
alt_id: CHEBI:22622
alt_id: CHEBI:22646
alt_id: CHEBI:2834
alt_id: CHEBI:2863
def: "An amino compound in which the amino group is linked directly to an aromatic system." []
subset: 3_STAR
synonym: "aromatic amines" RELATED [ChEBI]
synonym: "aryl amine" RELATED [ChEBI]
synonym: "aryl amines" RELATED [ChEBI]
synonym: "arylamine" RELATED [ChEBI]
synonym: "arylamines" RELATED [ChEBI]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:33861
name: transition element coordination entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "transition element coordination entities" RELATED [ChEBI]
synonym: "transition metal coordination compounds" RELATED [ChEBI]
synonym: "transition metal coordination entities" RELATED [ChEBI]
is_a: CHEBI:33240 ! coordination entity
is_a: CHEBI:33497 ! transition element molecular entity

[Term]
id: CHEBI:33862
name: platinum coordination entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "platinum coordination compounds" RELATED [ChEBI]
synonym: "platinum coordination entities" RELATED [ChEBI]
synonym: "platinum coordination entity" EXACT [ChEBI]
is_a: CHEBI:33749 ! platinum molecular entity
is_a: CHEBI:33861 ! transition element coordination entity

[Term]
id: CHEBI:33893
name: reagent
namespace: chebi_ontology
def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." []
subset: 3_STAR
synonym: "reactif" RELATED [IUPAC]
synonym: "reactivo" RELATED [IUPAC]
synonym: "reagent" EXACT IUPAC_NAME [IUPAC]
synonym: "reagents" RELATED [ChEBI]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:33937
name: macronutrient
namespace: chebi_ontology
def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." []
subset: 3_STAR
synonym: "macronutrients" RELATED [ChEBI]
is_a: CHEBI:33284 ! nutrient

[Term]
id: CHEBI:33958
name: halide salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "halide salts" RELATED [ChEBI]
synonym: "halides" RELATED [ChEBI]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:37578 ! halide
relationship: BFO:0000051 CHEBI:16042 ! has part halide anion

[Term]
id: CHEBI:34699
name: diethyl sulfate
namespace: chebi_ontology
def: "The diethyl ester of sulfuric acid." []
subset: 3_STAR
synonym: "DES" RELATED [KEGG_COMPOUND]
synonym: "Diaethylsulfat" RELATED [ChemIDplus]
synonym: "diethyl sulphate" RELATED [ChemIDplus]
synonym: "diethyl tetraoxosulfate" RELATED [ChemIDplus]
synonym: "diethylsulfate" RELATED [ChemIDplus]
synonym: "Et2SO4" RELATED [ChEBI]
synonym: "ethyl sulfate" RELATED [ChEBI]
synonym: "sulfuric acid diethyl ester" RELATED [ChemIDplus]
synonym: "sulphuric acid diethyl ester" RELATED [NIST_Chemistry_WebBook]
xref: CAS:64-67-5 {source="ChemIDplus"}
xref: CAS:64-67-5 {source="NIST Chemistry WebBook"}
xref: CBA:310330 {source="Europe PMC"}
xref: CBA:374048 {source="Europe PMC"}
xref: CBA:593867 {source="Europe PMC"}
xref: Chemspider:5931
xref: HMDB:HMDB0251240
xref: KEGG:C14706
xref: PMID:15323041 {source="Europe PMC"}
xref: PMID:17619463 {source="Europe PMC"}
xref: PMID:20566339 {source="Europe PMC"}
xref: PMID:21089860 {source="Europe PMC"}
xref: PMID:21852824 {source="Europe PMC"}
xref: PMID:23830811 {source="Europe PMC"}
xref: PMID:24681631 {source="Europe PMC"}
xref: PMID:24686557 {source="Europe PMC"}
xref: PMID:25484124 {source="Europe PMC"}
xref: PMID:26591512 {source="Europe PMC"}
xref: PMID:2797029 {source="Europe PMC"}
xref: PMID:2927429 {source="Europe PMC"}
xref: PMID:29397772 {source="Europe PMC"}
xref: PMID:29615826 {source="Europe PMC"}
xref: PMID:30417660 {source="Europe PMC"}
xref: PMID:3312952 {source="Europe PMC"}
xref: Wikipedia:Diethyl_sulfate
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:29281 ! alkyl sulfate
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H10O4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H10O4S/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DENRZWYUOJLTMF-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "154.180" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "154.02998" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCOS(=O)(=O)OCC" xsd:string

[Term]
id: CHEBI:34873
name: N-nitrosodiethylamine
namespace: chebi_ontology
def: "A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom." []
subset: 3_STAR
synonym: "1,1-diethyl-2-oxohydrazine" RELATED [NIST_Chemistry_WebBook]
synonym: "DANA" RELATED [NIST_Chemistry_WebBook]
synonym: "DEN" RELATED [NIST_Chemistry_WebBook]
synonym: "Diethylnitrosamine" RELATED [KEGG_COMPOUND]
synonym: "diethylnitrosoamine" RELATED [ChemIDplus]
synonym: "N,N-diethylnitrosamine" RELATED [ChemIDplus]
synonym: "N,N-diethylnitrosoamine" RELATED [ChemIDplus]
synonym: "N-ethyl-N-nitrosoethanamine" EXACT IUPAC_NAME [IUPAC]
synonym: "N-Nitrosodiethylamine" EXACT [KEGG_COMPOUND]
synonym: "NDEA" RELATED [KEGG_COMPOUND]
xref: Beilstein:1744991 {source="Beilstein"}
xref: CAS:55-18-5 {source="NIST Chemistry WebBook"}
xref: CAS:55-18-5 {source="ChemIDplus"}
xref: CAS:55-18-5 {source="KEGG COMPOUND"}
xref: KEGG:C14422
xref: PMID:24696076 {source="Europe PMC"}
xref: PMID:24755254 {source="Europe PMC"}
xref: Reaxys:1744991 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35803 ! nitrosamine
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H10N2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WBNQDOYYEUMPFS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "102.135" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.07931" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CC)N=O" xsd:string

[Term]
id: CHEBI:35106
name: nitrogen hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "nitrogen hydrides" RELATED [ChEBI]
is_a: CHEBI:35881 ! pnictogen hydride
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35107
name: azane
namespace: chebi_ontology
def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." []
subset: 3_STAR
synonym: "azanes" RELATED [ChEBI]
is_a: CHEBI:35106 ! nitrogen hydride

[Term]
id: CHEBI:35175
name: sulfate salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfate salts" RELATED [ChEBI]
synonym: "sulfates" RELATED [ChEBI]
synonym: "sulphate salts" RELATED [ChEBI]
synonym: "sulphates" RELATED [ChEBI]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:26820 ! sulfates

[Term]
id: CHEBI:35221
name: antimetabolite
namespace: chebi_ontology
def: "A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." []
subset: 3_STAR
synonym: "antimetabolite" EXACT IUPAC_NAME [IUPAC]
synonym: "antimetabolites" RELATED [ChEBI]
xref: Wikipedia:Antimetabolite
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:35222
name: inhibitor
namespace: chebi_ontology
def: "A substance that diminishes the rate of a chemical reaction." []
subset: 3_STAR
synonym: "inhibidor" RELATED [ChEBI]
synonym: "inhibiteur" RELATED [ChEBI]
synonym: "inhibitor" EXACT IUPAC_NAME [IUPAC]
synonym: "inhibitors" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:35223
name: catalyst
namespace: chebi_ontology
def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." []
subset: 3_STAR
synonym: "catalizador" RELATED [ChEBI]
synonym: "catalyseur" RELATED [ChEBI]
synonym: "catalyst" EXACT IUPAC_NAME [IUPAC]
synonym: "Katalysator" RELATED [ChEBI]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:35237
name: cysteine zwitterion
namespace: chebi_ontology
subset: 3_STAR
synonym: "(+)H3N-CH(CH2SH)-COO(-)" RELATED [ChEBI]
synonym: "2-ammonio-3-mercaptopropanoate" RELATED [ChEBI]
synonym: "2-ammonio-3-sulfanylpropanoate" EXACT IUPAC_NAME [IUPAC]
synonym: "cysteine zwitterion" EXACT [IUPAC]
xref: Gmelin:49992 {source="Gmelin"}
is_a: CHEBI:35238 ! amino acid zwitterion
relationship: is_conjugate_acid_of CHEBI:32456 ! cysteinate(1-)
relationship: is_conjugate_base_of CHEBI:32458 ! cysteinium
relationship: is_tautomer_of CHEBI:15356 ! cysteine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7NO2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUJNEKJLAYXESH-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "121.15922" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "121.01975" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CS)C([O-])=O" xsd:string

[Term]
id: CHEBI:35238
name: amino acid zwitterion
namespace: chebi_ontology
def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." []
subset: 3_STAR
synonym: "amino acid zwitterion" EXACT [ChEBI]
is_a: CHEBI:27369 ! zwitterion

[Term]
id: CHEBI:35274
name: ammonium ion derivative
namespace: chebi_ontology
def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." []
subset: 3_STAR
synonym: "ammonium ion derivatives" RELATED [ChEBI]
synonym: "azanium ion derivative" RELATED [ChEBI]
synonym: "azanium ion derivatives" RELATED [ChEBI]
is_a: CHEBI:33702 ! polyatomic cation
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: has_parent_hydride CHEBI:28938 ! ammonium

[Term]
id: CHEBI:35286
name: iminium ion
namespace: chebi_ontology
def: "Cations of structure R2C=N(+)R2." []
subset: 3_STAR
synonym: "iminium cations" RELATED [ChEBI]
synonym: "iminium ion" EXACT [ChEBI]
synonym: "iminium ions" RELATED [ChEBI]
is_a: CHEBI:25697 ! organic cation

[Term]
id: CHEBI:35293
name: fused compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "fused compounds" RELATED [ChEBI]
synonym: "fused polycyclic compounds" RELATED [ChEBI]
synonym: "fused-ring polycyclic compound" RELATED [ChEBI]
synonym: "fused-ring polycyclic compounds" RELATED [ChEBI]
synonym: "polycyclic fused-ring compounds" RELATED [ChEBI]
is_a: CHEBI:33635 ! polycyclic compound

[Term]
id: CHEBI:35294
name: carbopolycyclic compound
namespace: chebi_ontology
def: "A polyclic compound in which all of the ring members are carbon atoms." []
subset: 3_STAR
synonym: "carbopolycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33598 ! carbocyclic compound
is_a: CHEBI:35295 ! homopolycyclic compound

[Term]
id: CHEBI:35295
name: homopolycyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "homopolycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33597 ! homocyclic compound
is_a: CHEBI:33635 ! polycyclic compound

[Term]
id: CHEBI:35296
name: ortho-fused polycyclic arene
namespace: chebi_ontology
subset: 3_STAR
synonym: "ortho-fused polycyclic arenes" RELATED [ChEBI]
is_a: CHEBI:33848 ! polycyclic arene
is_a: CHEBI:35427 ! ortho-fused polycyclic hydrocarbon

[Term]
id: CHEBI:35299
name: dibenz[a,h]anthracene
namespace: chebi_ontology
alt_id: CHEBI:18901
alt_id: CHEBI:34684
subset: 3_STAR
synonym: "1,2:5,6-Dibenzanthracene" RELATED [KEGG_COMPOUND]
synonym: "DBA" RELATED [ChemIDplus]
synonym: "Dibenz[a,h]anthracene" EXACT [KEGG_COMPOUND]
xref: CAS:53-70-3 {source="KEGG COMPOUND"}
xref: CAS:53-70-3 {source="NIST Chemistry WebBook"}
xref: CAS:53-70-3 {source="ChemIDplus"}
xref: KEGG:C14325
is_a: CHEBI:35296 ! ortho-fused polycyclic arene
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H14" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H14/c1-3-7-19-15(5-1)9-11-17-14-22-18(13-21(17)19)12-10-16-6-2-4-8-20(16)22/h1-14H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LHRCREOYAASXPZ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "278.34656" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "278.10955" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2c(c1)ccc1cc3c(ccc4ccccc34)cc21" xsd:string

[Term]
id: CHEBI:35300
name: ortho- and peri-fused polycyclic arene
namespace: chebi_ontology
subset: 3_STAR
synonym: "ortho- and peri-fused polycyclic arenes" RELATED [ChEBI]
is_a: CHEBI:33639 ! ortho- and peri-fused compound
is_a: CHEBI:33848 ! polycyclic arene

[Term]
id: CHEBI:35337
name: central nervous system stimulant
namespace: chebi_ontology
def: "Any drug that enhances the activity of the central nervous system." []
subset: 3_STAR
synonym: "analeptic" RELATED [ChEBI]
synonym: "analeptic agent" RELATED [ChEBI]
synonym: "analeptic drug" RELATED [ChEBI]
synonym: "analeptics" RELATED [ChEBI]
synonym: "central nervous system stimulant" EXACT [ChEBI]
synonym: "central stimulant" RELATED [ChEBI]
synonym: "CNS stimulant" RELATED [ChEBI]
xref: Wikipedia:Central_nervous_system_stimulants
is_a: CHEBI:35470 ! central nervous system drug

[Term]
id: CHEBI:35352
name: organonitrogen compound
namespace: chebi_ontology
def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." []
subset: 3_STAR
synonym: "organonitrogen compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "organonitrogens" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35359
name: carboxamidine
namespace: chebi_ontology
def: "Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom." []
subset: 3_STAR
synonym: "Amidines" RELATED [KEGG_COMPOUND]
synonym: "carboxamidines" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxamidines" RELATED [ChEBI]
xref: KEGG:C06060
is_a: CHEBI:2634 ! amidine
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:35366
name: fatty acid
namespace: chebi_ontology
alt_id: CHEBI:13633
alt_id: CHEBI:24024
alt_id: CHEBI:4984
def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." []
subset: 3_STAR
synonym: "acide gras" RELATED [ChEBI]
synonym: "acides gras" RELATED [ChemIDplus]
synonym: "acido graso" RELATED [ChEBI]
synonym: "acidos grasos" RELATED [ChEBI]
synonym: "Fatty acid" EXACT [KEGG_COMPOUND]
synonym: "fatty acids" EXACT IUPAC_NAME [IUPAC]
synonym: "fatty acids" RELATED [ChEBI]
synonym: "Fettsaeure" RELATED [ChEBI]
synonym: "Fettsaeuren" RELATED [ChEBI]
xref: KEGG:C00162
xref: PMID:14287444 {source="Europe PMC"}
xref: PMID:14300208 {source="Europe PMC"}
xref: PMID:14328676 {source="Europe PMC"}
xref: Wikipedia:Fatty_acid
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: is_conjugate_acid_of CHEBI:28868 ! fatty acid anion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01740" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string

[Term]
id: CHEBI:35406
name: oxoanion
namespace: chebi_ontology
alt_id: CHEBI:33274
alt_id: CHEBI:33436
def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." []
subset: 3_STAR
synonym: "oxoacid anions" RELATED [ChEBI]
synonym: "oxoanion" EXACT [ChEBI]
synonym: "oxoanions" RELATED [ChEBI]
is_a: CHEBI:25741 ! oxide
is_a: CHEBI:33273 ! polyatomic anion

[Term]
id: CHEBI:35426
name: ortho-fused bicyclic arene
namespace: chebi_ontology
subset: 3_STAR
synonym: "ortho-fused bicyclic arene" EXACT [ChEBI]
synonym: "ortho-fused bicyclic arenes" RELATED [ChEBI]
is_a: CHEBI:35296 ! ortho-fused polycyclic arene
is_a: CHEBI:35428 ! ortho-fused bicyclic hydrocarbon

[Term]
id: CHEBI:35427
name: ortho-fused polycyclic hydrocarbon
namespace: chebi_ontology
subset: 3_STAR
synonym: "ortho-fused polycyclic hydrocarbon" EXACT [ChEBI]
synonym: "ortho-fused polycyclic hydrocarbons" RELATED [ChEBI]
is_a: CHEBI:33637 ! ortho-fused compound

[Term]
id: CHEBI:35428
name: ortho-fused bicyclic hydrocarbon
namespace: chebi_ontology
subset: 3_STAR
synonym: "ortho-fused bicyclic hydrocarbon" EXACT [ChEBI]
synonym: "ortho-fused bicyclic hydrocarbons" RELATED [ChEBI]
is_a: CHEBI:33637 ! ortho-fused compound
is_a: CHEBI:36785 ! carbobicyclic compound

[Term]
id: CHEBI:35441
name: antiinfective agent
namespace: chebi_ontology
def: "A substance used in the prophylaxis or therapy of infectious diseases." []
subset: 3_STAR
synonym: "anti-infective agents" RELATED [ChEBI]
synonym: "anti-infective drugs" RELATED [ChEBI]
synonym: "antiinfective agents" RELATED [ChEBI]
synonym: "antiinfective drug" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35442
name: antiparasitic agent
namespace: chebi_ontology
def: "A substance used to treat or prevent parasitic infections." []
subset: 3_STAR
synonym: "antiparasitic drugs" RELATED [ChEBI]
synonym: "antiparasitics" RELATED [ChEBI]
synonym: "parasiticides" RELATED [ChEBI]
xref: Wikipedia:Antiparasitic
is_a: CHEBI:35441 ! antiinfective agent

[Term]
id: CHEBI:35443
name: anthelminthic drug
namespace: chebi_ontology
def: "Substance intended to kill parasitic worms (helminths)." []
subset: 3_STAR
synonym: "anthelminthic" EXACT IUPAC_NAME [IUPAC]
synonym: "anthelminthics" RELATED [ChEBI]
synonym: "anthelmintic" RELATED [IUPAC]
synonym: "anthelmintics" RELATED [ChEBI]
synonym: "antihelminth" RELATED [ChEBI]
synonym: "antihelmintico" RELATED [ChEBI]
synonym: "vermifuge" RELATED [ChEBI]
is_a: CHEBI:35442 ! antiparasitic agent

[Term]
id: CHEBI:35444
name: antinematodal drug
namespace: chebi_ontology
def: "A substance used in the treatment or control of nematode infestations." []
subset: 3_STAR
synonym: "antinematodal agent" RELATED [ChEBI]
synonym: "antinematodal drugs" RELATED [ChEBI]
synonym: "antinematodals" RELATED [ChEBI]
is_a: CHEBI:25491 ! nematicide
is_a: CHEBI:35443 ! anthelminthic drug

[Term]
id: CHEBI:35470
name: central nervous system drug
namespace: chebi_ontology
def: "A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system." []
subset: 3_STAR
synonym: "central nervous system agents" RELATED [ChEBI]
synonym: "CNS agent" RELATED [ChEBI]
synonym: "CNS drugs" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35471
name: psychotropic drug
namespace: chebi_ontology
def: "A loosely defined grouping of drugs that have effects on psychological function." []
subset: 3_STAR
synonym: "psychoactive agent" RELATED [ChEBI]
synonym: "psychoactive drugs" RELATED [ChEBI]
synonym: "psychopharmaceuticals" RELATED [ChEBI]
synonym: "psychotropic drugs" RELATED [ChEBI]
xref: Wikipedia:Psychotropic_drug
is_a: CHEBI:35470 ! central nervous system drug

[Term]
id: CHEBI:35479
name: alkali metal salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "alkali metal salts" RELATED [ChEBI]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:33296 ! alkali metal molecular entity

[Term]
id: CHEBI:35480
name: analgesic
namespace: chebi_ontology
def: "An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms." []
subset: 3_STAR
is_a: CHEBI:23888 ! drug
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:35481
name: non-narcotic analgesic
namespace: chebi_ontology
def: "A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors." []
subset: 3_STAR
is_a: CHEBI:35480 ! analgesic

[Term]
id: CHEBI:35498
name: diuretic
namespace: chebi_ontology
def: "An agent that promotes the excretion of urine through its effects on kidney function." []
subset: 3_STAR
synonym: "diuretics" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35504
name: addition compound
namespace: chebi_ontology
def: "An addition compound contains two or more simpler compounds that can be packed in a definite ratio into a crystal. The term covers donor-acceptor complexes (adducts) and a variety of lattice compounds." []
subset: 3_STAR
synonym: "addition compounds" RELATED [ChEBI]
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:35552
name: heterocyclic organic fundamental parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "heterocyclic fundamental parent" RELATED [ChEBI]
synonym: "heterocyclic organic fundamental parents" RELATED [ChEBI]
synonym: "heterocyclic parent hydrides" EXACT IUPAC_NAME [IUPAC]
synonym: "organic heterocyclic fundamental parents" RELATED [ChEBI]
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:35568
name: mancude ring
namespace: chebi_ontology
def: "Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds." []
subset: 3_STAR
synonym: "mancude rings" RELATED [ChEBI]
synonym: "mancude-ring systems" EXACT IUPAC_NAME [IUPAC]
synonym: "mancunide-ring systems" RELATED [IUPAC]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:35570
name: mancude organic heterobicyclic parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "mancude organic heterobicyclic parents" RELATED [ChEBI]
synonym: "mancude-ring organic heterobicyclic parents" RELATED [ChEBI]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:35571 ! mancude organic heterocyclic parent

[Term]
id: CHEBI:35571
name: mancude organic heterocyclic parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "mancude organic heterocyclic parents" RELATED [ChEBI]
synonym: "mancude-ring organic heterocyclic parents" RELATED [ChEBI]
is_a: CHEBI:35552 ! heterocyclic organic fundamental parent
is_a: CHEBI:35573 ! organic mancude parent

[Term]
id: CHEBI:35573
name: organic mancude parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic mancude parents" RELATED [ChEBI]
synonym: "organic mancude-ring parents" RELATED [ChEBI]
is_a: CHEBI:33245 ! organic fundamental parent
is_a: CHEBI:35568 ! mancude ring

[Term]
id: CHEBI:35584
name: purine
namespace: chebi_ontology
def: "A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines." []
subset: 3_STAR
synonym: "purine" EXACT IUPAC_NAME [IUPAC]
xref: HMDB:HMDB0001366
xref: KEGG:C15587
xref: MetaCyc:PURINE
xref: PMID:12865945 {source="Europe PMC"}
xref: PMID:24088627 {source="Europe PMC"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:26401 ! purines
is_a: CHEBI:35570 ! mancude organic heterobicyclic parent
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "120.112" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string

[Term]
id: CHEBI:35586
name: 1H-purine
namespace: chebi_ontology
def: "The 1H-tautomer of purine." []
subset: 3_STAR
synonym: "1H-purine" EXACT [ChEBI]
xref: Gmelin:2379911 {source="Gmelin"}
is_a: CHEBI:35584 ! purine
relationship: is_tautomer_of CHEBI:17258 ! 7H-purine
relationship: is_tautomer_of CHEBI:35588 ! 3H-purine
relationship: is_tautomer_of CHEBI:35589 ! 9H-purine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11210" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1nc2c[nH]cnc2n1" xsd:string

[Term]
id: CHEBI:35588
name: 3H-purine
namespace: chebi_ontology
def: "The 3H-tautomer of purine." []
subset: 3_STAR
synonym: "3H-purine" EXACT IUPAC_NAME [IUPAC]
xref: PMID:6149478 {source="Europe PMC"}
xref: PMID:7178185 {source="Europe PMC"}
xref: PMID:7296170 {source="Europe PMC"}
xref: Reaxys:1210196 {source="Reaxys"}
is_a: CHEBI:35584 ! purine
relationship: is_tautomer_of CHEBI:17258 ! 7H-purine
relationship: is_tautomer_of CHEBI:35586 ! 1H-purine
relationship: is_tautomer_of CHEBI:35589 ! 9H-purine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11222" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1nc2cnc[nH]c2n1" xsd:string

[Term]
id: CHEBI:35589
name: 9H-purine
namespace: chebi_ontology
def: "The 9H-tautomer of purine." []
subset: 3_STAR
synonym: "9H-purine" EXACT IUPAC_NAME [IUPAC]
synonym: "9H-purine" EXACT [UniProt]
xref: Beilstein:606899 {source="Beilstein"}
xref: CAS:120-73-0 {source="NIST Chemistry WebBook"}
xref: Gmelin:3120 {source="Gmelin"}
xref: Wikipedia:Purine
is_a: CHEBI:35584 ! purine
relationship: is_tautomer_of CHEBI:17258 ! 7H-purine
relationship: is_tautomer_of CHEBI:35586 ! 1H-purine
relationship: is_tautomer_of CHEBI:35588 ! 3H-purine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11222" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ncc2nc[nH]c2n1" xsd:string

[Term]
id: CHEBI:35604
name: carbon oxoanion
namespace: chebi_ontology
def: "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." []
subset: 3_STAR
synonym: "carbon oxoanion" EXACT [ChEBI]
synonym: "carbon oxoanions" RELATED [ChEBI]
synonym: "oxocarbon anion" RELATED [ChEBI]
synonym: "oxocarbon anions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35605
name: carbon oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbon oxoacids" RELATED [ChEBI]
synonym: "oxoacids of carbon" RELATED [ChEBI]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35610
name: antineoplastic agent
namespace: chebi_ontology
def: "A substance that inhibits or prevents the proliferation of neoplasms." []
subset: 3_STAR
synonym: "anticancer agent" RELATED [ChEBI]
synonym: "anticancer agents" RELATED [ChEBI]
synonym: "antineoplastic" RELATED [ChEBI]
synonym: "antineoplastic agents" RELATED [ChEBI]
synonym: "cytostatic" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35618
name: aromatic ether
namespace: chebi_ontology
def: "Any ether in which the oxygen is attached to at least one aryl substituent." []
subset: 3_STAR
is_a: CHEBI:25698 ! ether
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:35682
name: naphthol
namespace: chebi_ontology
def: "A member of the class of naphthols carrying a single hydroxy substituent at C-1 or C-2. A closed class." []
subset: 3_STAR
synonym: "hydroxynaphthalene" RELATED [ChEBI]
synonym: "naphthalenol" EXACT IUPAC_NAME [IUPAC]
synonym: "naphthol" EXACT [IUPAC]
xref: CAS:1321-67-1 {source="ChemIDplus"}
is_a: CHEBI:139520 ! phenolic donor
is_a: CHEBI:25392 ! naphthols
relationship: has_parent_hydride CHEBI:16482 ! naphthalene
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H8O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "144.170" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "144.05751" xsd:string

[Term]
id: CHEBI:35684
name: antiplatyhelmintic drug
namespace: chebi_ontology
def: "An agent used to treat cestode, trematode, or other flatworm infestations in man or animals." []
subset: 3_STAR
synonym: "antiplatyhelmintic agent" RELATED [ChEBI]
synonym: "antiplatyhelmintic drugs" RELATED [ChEBI]
is_a: CHEBI:35443 ! anthelminthic drug

[Term]
id: CHEBI:35692
name: dicarboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:23692
alt_id: CHEBI:36172
alt_id: CHEBI:4501
def: "Any carboxylic acid containing two carboxy groups." []
subset: 3_STAR
synonym: "Dicarboxylic acid" EXACT [KEGG_COMPOUND]
synonym: "dicarboxylic acids" RELATED [ChEBI]
xref: KEGG:C02028
is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
is_a: CHEBI:33575 ! carboxylic acid
relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: CHEBI:35693
name: dicarboxylic acid anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "dicarboxylic acid anion" EXACT [ChEBI]
synonym: "dicarboxylic acid anions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid

[Term]
id: CHEBI:35701
name: ester
namespace: chebi_ontology
alt_id: CHEBI:23960
alt_id: CHEBI:4859
def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
subset: 3_STAR
synonym: "Ester" EXACT [KEGG_COMPOUND]
synonym: "esters" RELATED [ChEBI]
xref: KEGG:C00287
xref: Wikipedia:Ester
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35702
name: diethyl ether
namespace: chebi_ontology
alt_id: CHEBI:23991
alt_id: CHEBI:31565
def: "An ether in which the oxygen atom is linked to two ethyl groups." []
subset: 3_STAR
synonym: "1,1'-oxybisethane" RELATED [ChemIDplus]
synonym: "1,1'-oxydiethane" EXACT IUPAC_NAME [IUPAC]
synonym: "3-oxapentane" RELATED [ChemIDplus]
synonym: "Aether" RELATED [ChEBI]
synonym: "aether" RELATED [NIST_Chemistry_WebBook]
synonym: "aether pro narcosi" RELATED [ChEBI]
synonym: "Anesthetic ether" RELATED [KEGG_COMPOUND]
synonym: "Diethyl ether" EXACT [KEGG_COMPOUND]
synonym: "diethyl oxide" RELATED [ChemIDplus]
synonym: "Diethylaether" RELATED [ChEBI]
synonym: "Ether" RELATED [KEGG_COMPOUND]
synonym: "ethoxyethane" RELATED [ChemIDplus]
synonym: "ethyl ether" RELATED [ChemIDplus]
synonym: "ethyl oxide" RELATED [ChemIDplus]
synonym: "Pronarcol" RELATED [NIST_Chemistry_WebBook]
synonym: "R-610" RELATED [ChEBI]
xref: Beilstein:1696894 {source="Beilstein"}
xref: CAS:60-29-7 {source="NIST Chemistry WebBook"}
xref: CAS:60-29-7 {source="ChemIDplus"}
xref: CAS:60-29-7 {source="KEGG COMPOUND"}
xref: Drug_Central:4417 {source="DrugCentral"}
xref: Gmelin:25444 {source="Gmelin"}
xref: KEGG:C13240
xref: KEGG:D01772
xref: PMID:24443836 {source="Europe PMC"}
xref: Reaxys:1696894 {source="Reaxys"}
xref: Wikipedia:Diethyl_ether
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:25698 ! ether
relationship: RO:0000087 CHEBI:38870 ! has role inhalation anaesthetic
relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H10O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RTZKZFJDLAIYFH-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.12160" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.07316" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCOCC" xsd:string

[Term]
id: CHEBI:35703
name: xenobiotic
namespace: chebi_ontology
alt_id: CHEBI:10074
alt_id: CHEBI:27333
def: "A xenobiotic (Greek, xenos \"foreign\"; bios \"life\") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means." []
subset: 3_STAR
synonym: "Xenobiotic" EXACT [KEGG_COMPOUND]
synonym: "xenobiotic" EXACT IUPAC_NAME [IUPAC]
synonym: "xenobiotic compounds" RELATED [ChEBI]
synonym: "xenobiotics" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C06708
xref: Wikipedia:Xenobiotic
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:35705
name: immunosuppressive agent
namespace: chebi_ontology
def: "An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response." []
subset: 3_STAR
synonym: "immunosuppressant" RELATED [ChEBI]
synonym: "immunosuppressive agents" RELATED [ChEBI]
synonym: "inmunosupresor" RELATED [ChEBI]
is_a: CHEBI:50846 ! immunomodulator

[Term]
id: CHEBI:35715
name: nitro compound
namespace: chebi_ontology
def: "A compound having a nitro group, -NO2 (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, C-nitro compounds are usually implied)." []
subset: 3_STAR
synonym: "nitro compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: BFO:0000051 CHEBI:29785 ! has part nitro group

[Term]
id: CHEBI:35757
name: monocarboxylic acid anion
namespace: chebi_ontology
alt_id: CHEBI:13657
alt_id: CHEBI:25382
alt_id: CHEBI:3407
def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." []
subset: 3_STAR
synonym: "a monocarboxylate" RELATED [UniProt]
synonym: "Carboxylate" RELATED [KEGG_COMPOUND]
synonym: "Monocarboxylate" RELATED [KEGG_COMPOUND]
synonym: "monocarboxylates" RELATED [ChEBI]
synonym: "monocarboxylic acid anions" RELATED [ChEBI]
xref: KEGG:C00060
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.01000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string

[Term]
id: CHEBI:35780
name: phosphate ion
namespace: chebi_ontology
def: "A phosphorus oxoanion that is the conjugate base of phosphoric acid." []
subset: 3_STAR
synonym: "phosphate" RELATED [ChEBI]
synonym: "phosphate ions" RELATED [ChEBI]
synonym: "Pi" RELATED [ChEBI]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33461 ! phosphorus oxoanion
relationship: is_conjugate_base_of CHEBI:26078 ! phosphoric acid
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:35800
name: nitroso compound
namespace: chebi_ontology
def: "Compounds having the nitroso group, -NO, attached to carbon, or to another element, most commonly nitrogen or oxygen." []
subset: 3_STAR
synonym: "nitroso compounds" RELATED [ChEBI]
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: BFO:0000051 CHEBI:35801 ! has part nitroso group

[Term]
id: CHEBI:35801
name: nitroso group
namespace: chebi_ontology
subset: 3_STAR
synonym: "-N=O" RELATED [IUPAC]
synonym: "nitroso" EXACT IUPAC_NAME [IUPAC]
synonym: "O=N-" RELATED [IUPAC]
is_a: CHEBI:33246 ! inorganic group
is_a: CHEBI:51144 ! nitrogen group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "NO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "30.00614" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.99799" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=N*" xsd:string

[Term]
id: CHEBI:35803
name: nitrosamine
namespace: chebi_ontology
def: "N-Nitroso amines, compounds of the structure R2NNO. Compounds RNHNO are not ordinarily isolable, but they, too, are nitrosamines. The name is a contraction of N-nitrosoamine and, as such, does not require the N locant." []
subset: 3_STAR
synonym: "N-Nitroso amines" RELATED [IUPAC]
synonym: "nitrosamines" RELATED [ChEBI]
xref: Wikipedia:Nitrosamine
is_a: CHEBI:35800 ! nitroso compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "N2OR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.01280" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.00106" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N([*])N=O" xsd:string

[Term]
id: CHEBI:35807
name: N-nitrosodimethylamine
namespace: chebi_ontology
alt_id: CHEBI:21778
alt_id: CHEBI:34874
subset: 3_STAR
synonym: "1,1-Dimethyl-2-oxohydrazine" RELATED [NIST_Chemistry_WebBook]
synonym: "Dimethylnitrosamine" RELATED [KEGG_COMPOUND]
synonym: "Dimethylnitrosoamine" RELATED [ChemIDplus]
synonym: "DMN" RELATED [ChemIDplus]
synonym: "N,N-Dimethylnitrosamine" RELATED [ChemIDplus]
synonym: "N-methyl-N-nitrosomethanamine" EXACT IUPAC_NAME [IUPAC]
synonym: "N-Nitrosodimethylamine" EXACT [ChemIDplus]
synonym: "N-Nitrosodimethylamine" EXACT [KEGG_COMPOUND]
xref: CAS:62-75-9 {source="KEGG COMPOUND"}
xref: CAS:62-75-9 {source="ChemIDplus"}
xref: CAS:62-75-9 {source="NIST Chemistry WebBook"}
xref: FooDB:FDB003496
xref: HMDB:HMDB0031419
xref: KEGG:C14704
xref: MetaCyc:CPD-18996
xref: PMID:10688537 {source="Europe PMC"}
xref: PMID:15647563 {source="Europe PMC"}
xref: PMID:15672376 {source="Europe PMC"}
xref: PMID:16640298 {source="Europe PMC"}
xref: PMID:25556763 {source="Europe PMC"}
xref: PMID:32836149 {source="Europe PMC"}
xref: PMID:33849366 {source="Europe PMC"}
xref: PMID:34247699 {source="Europe PMC"}
xref: PMID:34546846 {source="Europe PMC"}
xref: PMID:8318659 {source="Europe PMC"}
xref: PMID:8951235 {source="Europe PMC"}
xref: PPDB:1645
xref: Wikipedia:N-Nitrosodimethylamine
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35803 ! nitrosamine
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H6N2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UMFJAHHVKNCGLG-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.08192" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.04801" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)N=O" xsd:string

[Term]
id: CHEBI:35820
name: antiprotozoal drug
namespace: chebi_ontology
def: "Any antimicrobial drug which is used to treat or prevent protozoal infections." []
subset: 3_STAR
synonym: "antiprotozoal agent" RELATED [ChEBI]
synonym: "antiprotozoal agents" RELATED [ChEBI]
synonym: "antiprotozoal drugs" RELATED [ChEBI]
xref: Wikipedia:Antiprotozoal_agent
is_a: CHEBI:35442 ! antiparasitic agent
is_a: CHEBI:36043 ! antimicrobial drug

[Term]
id: CHEBI:35875
name: imidazopyrimidine
namespace: chebi_ontology
subset: 3_STAR
synonym: "imidazopyrimidines" RELATED [ChEBI]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:35881
name: pnictogen hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "pnictogen hydride" EXACT [ChEBI]
synonym: "pnictogen hydrides" RELATED [ChEBI]
is_a: CHEBI:33242 ! inorganic hydride
is_a: CHEBI:33302 ! pnictogen molecular entity

[Term]
id: CHEBI:35942
name: neurotransmitter agent
namespace: chebi_ontology
def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." []
subset: 3_STAR
synonym: "neurotransmitter agents" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:36016
name: chloroethanes
namespace: chebi_ontology
def: "A chloroalkane that is ethane in which one or more of the  hydrogens is replaced by chlorine." []
subset: 3_STAR
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:23128 ! chloroalkane
relationship: has_parent_hydride CHEBI:42266 ! ethane

[Term]
id: CHEBI:36043
name: antimicrobial drug
namespace: chebi_ontology
def: "A drug used to treat or prevent microbial infections." []
subset: 3_STAR
synonym: "antimicrobial drugs" RELATED [ChEBI]
is_a: CHEBI:33281 ! antimicrobial agent
is_a: CHEBI:35441 ! antiinfective agent

[Term]
id: CHEBI:36044
name: antiviral drug
namespace: chebi_ontology
def: "A substance used in the prophylaxis or therapy of virus diseases." []
subset: 3_STAR
synonym: "anti-viral drug" RELATED [ChEBI]
synonym: "anti-virus drug" RELATED [ChEBI]
synonym: "antiviral drugs" RELATED [ChEBI]
is_a: CHEBI:22587 ! antiviral agent
is_a: CHEBI:36043 ! antimicrobial drug

[Term]
id: CHEBI:36094
name: organic chloride salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic chloride salts" RELATED [ChEBI]
is_a: CHEBI:23114 ! chloride salt
is_a: CHEBI:51069 ! organic halide salt

[Term]
id: CHEBI:36141
name: quinone
namespace: chebi_ontology
alt_id: CHEBI:13684
alt_id: CHEBI:26517
def: "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included)." []
subset: 3_STAR
synonym: "Chinon" RELATED [ChEBI]
synonym: "quinone" EXACT [IUPAC]
synonym: "quinones" EXACT IUPAC_NAME [IUPAC]
synonym: "quinones" RELATED [ChEBI]
xref: Wikipedia:Quinone
is_a: CHEBI:3992 ! cyclic ketone

[Term]
id: CHEBI:36233
name: disaccharide
namespace: chebi_ontology
alt_id: CHEBI:23844
alt_id: CHEBI:4654
def: "A compound in which two monosaccharides are joined by a glycosidic bond." []
subset: 3_STAR
synonym: "disacarido" RELATED [ChEBI]
synonym: "disacaridos" RELATED [IUPAC]
synonym: "Disaccharid" RELATED [ChEBI]
synonym: "Disaccharide" EXACT [KEGG_COMPOUND]
synonym: "disaccharides" EXACT IUPAC_NAME [IUPAC]
synonym: "Disacharid" RELATED [ChEBI]
xref: KEGG:C01911
is_a: CHEBI:50699 ! oligosaccharide

[Term]
id: CHEBI:36336
name: naphthalenesulfonic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "naphthalenesulfonic acids" RELATED [ChEBI]
is_a: CHEBI:25477 ! naphthalenes
is_a: CHEBI:33555 ! arenesulfonic acid

[Term]
id: CHEBI:36338
name: lepton
namespace: chebi_ontology
def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." []
subset: 3_STAR
synonym: "leptons" RELATED [ChEBI]
is_a: CHEBI:33233 ! fundamental particle
is_a: CHEBI:36340 ! fermion

[Term]
id: CHEBI:36339
name: baryon
namespace: chebi_ontology
def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." []
subset: 3_STAR
synonym: "baryons" RELATED [ChEBI]
is_a: CHEBI:36340 ! fermion
is_a: CHEBI:36344 ! hadron

[Term]
id: CHEBI:36340
name: fermion
namespace: chebi_ontology
def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." []
subset: 3_STAR
synonym: "fermion" EXACT IUPAC_NAME [IUPAC]
synonym: "fermions" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36342
name: subatomic particle
namespace: chebi_ontology
def: "A particle smaller than an atom." []
subset: 3_STAR
synonym: "subatomic particles" RELATED [ChEBI]
xref: Wikipedia:Subatomic_particle

[Term]
id: CHEBI:36343
name: composite particle
namespace: chebi_ontology
def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." []
subset: 3_STAR
synonym: "composite particles" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36344
name: hadron
namespace: chebi_ontology
def: "Hadron is a subatomic particle which experiences the strong force." []
subset: 3_STAR
synonym: "hadrons" RELATED [ChEBI]
is_a: CHEBI:36343 ! composite particle

[Term]
id: CHEBI:36347
name: nuclear particle
namespace: chebi_ontology
def: "A nucleus or any of its constituents in any of their energy states." []
subset: 3_STAR
synonym: "nuclear particle" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36357
name: polyatomic entity
namespace: chebi_ontology
def: "Any molecular entity consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic entities" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity
relationship: BFO:0000051 CHEBI:24433 ! has part group

[Term]
id: CHEBI:36358
name: polyatomic ion
namespace: chebi_ontology
def: "An ion consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:36360
name: phosphorus oxoacids and derivatives
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:26082 ! phosphorus molecular entity

[Term]
id: CHEBI:36388
name: saturated organic heterocyclic parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "saturated heterocyclic parent hydride" RELATED [ChEBI]
synonym: "saturated heterocyclic parent hydrides" RELATED [ChEBI]
synonym: "saturated organic heterocyclic parents" RELATED [ChEBI]
is_a: CHEBI:35552 ! heterocyclic organic fundamental parent

[Term]
id: CHEBI:36389
name: saturated organic heteromonocyclic parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "saturated heteromonocyclic parent hydride" RELATED [ChEBI]
synonym: "saturated heteromonocyclic parent hydrides" RELATED [ChEBI]
synonym: "saturated organic heteromonocyclic parents" RELATED [ChEBI]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:36388 ! saturated organic heterocyclic parent

[Term]
id: CHEBI:36416
name: mancude organic heterotricyclic parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "mancude organic heterotricyclic parents" RELATED [ChEBI]
synonym: "mancude-ring organic heterotricyclic parents" RELATED [ChEBI]
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:35571 ! mancude organic heterocyclic parent

[Term]
id: CHEBI:36420
name: acridine
namespace: chebi_ontology
def: "A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom." []
subset: 3_STAR
synonym: "10-azaanthracene" RELATED [ChemIDplus]
synonym: "2,3,5,6-dibenzopyridine" RELATED [ChemIDplus]
synonym: "2,3-benzoquinoline" RELATED [ChemIDplus]
synonym: "9-azaanthracene" RELATED [ChemIDplus]
synonym: "acridine" EXACT IUPAC_NAME [IUPAC]
synonym: "acrydine" RELATED [NIST_Chemistry_WebBook]
synonym: "Akridin" RELATED [NIST_Chemistry_WebBook]
synonym: "benzo[b]quinoline" RELATED [NIST_Chemistry_WebBook]
synonym: "dibenzo[b,e]pyridine" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:120200 {source="Beilstein"}
xref: CAS:260-94-6 {source="NIST Chemistry WebBook"}
xref: CAS:260-94-6 {source="ChemIDplus"}
xref: Gmelin:143403 {source="Gmelin"}
xref: PMID:11924543 {source="Europe PMC"}
xref: PMID:24416442 {source="Europe PMC"}
xref: Reaxys:120200 {source="Reaxys"}
xref: Wikipedia:Acridine
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22213 ! acridines
is_a: CHEBI:36416 ! mancude organic heterotricyclic parent
is_a: CHEBI:38180 ! polycyclic heteroarene
relationship: RO:0000087 CHEBI:50902 ! has role genotoxin
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H9N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DZBUGLKDJFMEHC-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "179.21730" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "179.07350" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2nc3ccccc3cc2c1" xsd:string

[Term]
id: CHEBI:36586
name: carbonyl compound
namespace: chebi_ontology
def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." []
subset: 3_STAR
synonym: "carbonyl compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:36587 ! organic oxo compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: BFO:0000051 CHEBI:23019 ! has part carbonyl group

[Term]
id: CHEBI:36587
name: organic oxo compound
namespace: chebi_ontology
def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." []
subset: 3_STAR
synonym: "organic oxo compounds" RELATED [ChEBI]
synonym: "oxo compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:72695 ! organic molecule
relationship: BFO:0000051 CHEBI:46629 ! has part oxo group

[Term]
id: CHEBI:36683
name: organochlorine compound
namespace: chebi_ontology
def: "An organochlorine compound is a compound containing at least one carbon-chlorine bond." []
subset: 3_STAR
synonym: "an organochlorine molecule" RELATED [UniProt]
synonym: "chloroorganic compounds" RELATED [ChEBI]
synonym: "chlororganische Verbindungen" RELATED [ChEBI]
synonym: "organochloride" RELATED [ChEBI]
synonym: "organochloride compound" RELATED [ChEBI]
synonym: "organochloride compounds" RELATED [ChEBI]
synonym: "organochlorides" RELATED [ChEBI]
synonym: "organochlorine compound" EXACT [ChEBI]
synonym: "organochlorine compounds" RELATED [ChEBI]
xref: MetaCyc:Chlorides
xref: Wikipedia:Organochloride
is_a: CHEBI:17792 ! organohalogen compound
is_a: CHEBI:23117 ! chlorine molecular entity
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "ClR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "35.453" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96885" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*Cl" xsd:string

[Term]
id: CHEBI:36688
name: heterotricyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "heterotricyclic compound" EXACT [ChEBI]
synonym: "heterotricyclic compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "heterotricyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33671 ! heteropolycyclic compound

[Term]
id: CHEBI:36785
name: carbobicyclic compound
namespace: chebi_ontology
def: "A bicyclic compound in which all the ring atoms are carbon." []
subset: 3_STAR
synonym: "carbobicyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33636 ! bicyclic compound
is_a: CHEBI:35294 ! carbopolycyclic compound

[Term]
id: CHEBI:36830
name: monoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoanions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string

[Term]
id: CHEBI:36892
name: elemental fluorine
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:33434 ! elemental halogen

[Term]
id: CHEBI:36895
name: monoatomic fluorine
namespace: chebi_ontology
subset: 3_STAR
synonym: "atomic fluorine" RELATED [ChEBI]
is_a: CHEBI:36892 ! elemental fluorine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "F" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "18.998" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99840" xsd:string

[Term]
id: CHEBI:36914
name: inorganic ion
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic ions" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36915
name: inorganic cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic cations" RELATED [ChEBI]
is_a: CHEBI:36914 ! inorganic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:36916
name: cation
namespace: chebi_ontology
alt_id: CHEBI:23058
alt_id: CHEBI:3473
def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." []
subset: 3_STAR
synonym: "Cation" EXACT [KEGG_COMPOUND]
synonym: "cation" EXACT IUPAC_NAME [IUPAC]
synonym: "cation" EXACT [ChEBI]
synonym: "cationes" RELATED [ChEBI]
synonym: "cations" RELATED [ChEBI]
synonym: "Kation" RELATED [ChEBI]
synonym: "Kationen" RELATED [ChEBI]
xref: KEGG:C01373
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36961
name: chalcocarbonic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "chalcocarbonic acid" EXACT [ChEBI]
synonym: "chalcocarbonic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "chalcocarbonic acids" RELATED [ChEBI]
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:36962
name: organochalcogen compound
namespace: chebi_ontology
def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." []
subset: 3_STAR
synonym: "organochalcogen compound" EXACT [ChEBI]
synonym: "organochalcogen compounds" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33304 ! chalcogen molecular entity

[Term]
id: CHEBI:36963
name: organooxygen compound
namespace: chebi_ontology
def: "An organochalcogen compound containing at least one carbon-oxygen bond." []
subset: 3_STAR
synonym: "organooxygen compound" EXACT [ChEBI]
synonym: "organooxygen compounds" RELATED [ChEBI]
xref: PMID:17586126 {source="Europe PMC"}
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:37022
name: amino-acid anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "amino acid anions" RELATED [ChEBI]
synonym: "amino-acid anion" EXACT [ChEBI]
synonym: "amino-acid anions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
is_a: CHEBI:35352 ! organonitrogen compound
relationship: is_conjugate_base_of CHEBI:33709 ! amino acid

[Term]
id: CHEBI:37141
name: organobromine compound
namespace: chebi_ontology
def: "A compound containing at least one carbon-bromine bond." []
subset: 3_STAR
synonym: "an organobromine molecule" RELATED [UniProt]
synonym: "bromoorganic compound" RELATED [ChEBI]
synonym: "organobromide" RELATED [ChEBI]
synonym: "organobromide compound" RELATED [ChEBI]
synonym: "organobromide compounds" RELATED [ChEBI]
synonym: "organobromides" RELATED [ChEBI]
synonym: "organobromine compound" EXACT [ChEBI]
synonym: "organobromine compounds" RELATED [ChEBI]
xref: MetaCyc:Bromide
xref: Wikipedia:Organobromine_compound
is_a: CHEBI:17792 ! organohalogen compound
is_a: CHEBI:22928 ! bromine molecular entity
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "BrR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "79.904" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "78.91834" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*Br" xsd:string

[Term]
id: CHEBI:37143
name: organofluorine compound
namespace: chebi_ontology
def: "An organofluorine compound is a compound containing at least one carbon-fluorine bond." []
subset: 3_STAR
synonym: "fluoroorganic compound" RELATED [ChEBI]
synonym: "fluoroorganic compounds" RELATED [ChEBI]
synonym: "fluoroorganics" RELATED [ChEBI]
synonym: "fluororganische Verbindungen" RELATED [ChEBI]
synonym: "organofluorine compound" EXACT [ChEBI]
synonym: "organofluorine compounds" RELATED [ChEBI]
xref: MetaCyc:Fluorides
is_a: CHEBI:17792 ! organohalogen compound
is_a: CHEBI:24062 ! fluorine molecular entity
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "FR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "18.998" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99840" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*F" xsd:string

[Term]
id: CHEBI:37175
name: organic hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic hydrides" RELATED [ChEBI]
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:37176
name: mononuclear parent hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "mononuclear hydride" RELATED [ChEBI]
synonym: "mononuclear hydrides" RELATED [IUPAC]
synonym: "mononuclear parent hydrides" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:37246
name: elemental sodium
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:26712 ! sodium molecular entity

[Term]
id: CHEBI:37334
name: diagnostic imaging agent
namespace: chebi_ontology
def: "A substance administered to enhance contrast in images of the inside of the body obtained using X-rays, gamma-rays, sound waves, radio waves (MRI), or radioactive particles in order to diagnose disease." []
subset: 3_STAR
is_a: CHEBI:33295 ! diagnostic agent

[Term]
id: CHEBI:37335
name: MRI contrast agent
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:37334 ! diagnostic imaging agent

[Term]
id: CHEBI:37404
name: elemental copper
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:23377 ! copper molecular entity

[Term]
id: CHEBI:37407
name: cyclic ether
namespace: chebi_ontology
alt_id: CHEBI:37406
def: "Any ether in which the oxygen atom forms part of a ring." []
subset: 3_STAR
synonym: "cyclic ether" EXACT [IUPAC]
synonym: "cyclic ethers" EXACT IUPAC_NAME [IUPAC]
synonym: "cyclic ethers" RELATED [ChEBI]
synonym: "epoxy compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "epoxy compounds" RELATED [ChEBI]
is_a: CHEBI:25698 ! ether
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:37445
name: folic acids
namespace: chebi_ontology
alt_id: CHEBI:24074
alt_id: CHEBI:24076
def: "A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid units." []
subset: 3_STAR
synonym: "folate" RELATED [ChEBI]
synonym: "folates" EXACT IUPAC_NAME [IUPAC]
synonym: "folates" RELATED [ChEBI]
is_a: CHEBI:176842 ! vitamin B9
is_a: CHEBI:26375 ! pterins
is_a: CHEBI:83982 ! L-glutamic acid derivative
relationship: is_conjugate_acid_of CHEBI:67011 ! folates

[Term]
id: CHEBI:37527
name: acid
namespace: chebi_ontology
alt_id: CHEBI:13800
alt_id: CHEBI:13801
alt_id: CHEBI:22209
alt_id: CHEBI:2426
def: "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." []
subset: 3_STAR
synonym: "Acid" EXACT [KEGG_COMPOUND]
synonym: "acid" EXACT IUPAC_NAME [IUPAC]
synonym: "acide" RELATED [IUPAC]
synonym: "acido" RELATED [ChEBI]
synonym: "acids" RELATED [ChEBI]
synonym: "Saeure" RELATED [ChEBI]
synonym: "Saeuren" RELATED [ChEBI]
xref: KEGG:C00174
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:37577
name: heteroatomic molecular entity
namespace: chebi_ontology
def: "A molecular entity consisting of two or more chemical elements." []
subset: 3_STAR
synonym: "chemical compound" RELATED [ChEBI]
synonym: "heteroatomic molecular entities" RELATED [ChEBI]
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:37578
name: halide
namespace: chebi_ontology
def: "Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements." []
subset: 3_STAR
synonym: "halides" RELATED [ChEBI]
xref: Wikipedia:Halide
is_a: CHEBI:24471 ! halogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:37594
name: N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine
namespace: chebi_ontology
subset: 3_STAR
synonym: "N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:498343 {source="Beilstein"}
is_a: CHEBI:22213 ! acridines
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H25Cl2N3O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H25Cl2N3O/c1-3-26(12-9-22)11-4-10-24-21-17-7-5-15(23)13-20(17)25-19-8-6-16(27-2)14-18(19)21/h5-8,13-14H,3-4,9-12H2,1-2H3,(H,24,25)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OIFINQAUHKZSBV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "406.34822" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "405.13747" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CCCl)CCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12" xsd:string

[Term]
id: CHEBI:37595
name: quinacrine mustard
namespace: chebi_ontology
alt_id: CHEBI:47635
subset: 3_STAR
synonym: "N(1),N(1)-bis(2-chloroethyl)-N(4)-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine" EXACT IUPAC_NAME [IUPAC]
synonym: "quinacrine mustard" EXACT [ChemIDplus]
xref: Beilstein:56337 {source="Beilstein"}
xref: CAS:64046-79-3 {source="ChemIDplus"}
is_a: CHEBI:37598 ! nitrogen mustard
is_a: CHEBI:51803 ! aminoacridines
relationship: has_functional_parent CHEBI:8711 ! quinacrine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H28Cl3N3O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H28Cl3N3O/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UKOBAUFLOGFCMV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "468.84614" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "467.12980" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1" xsd:string

[Term]
id: CHEBI:37598
name: nitrogen mustard
namespace: chebi_ontology
def: "Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR." []
subset: 3_STAR
synonym: "nitrogen mustard compound" RELATED [ChEBI]
synonym: "nitrogen mustard compounds" RELATED [ChEBI]
synonym: "nitrogen mustards" EXACT IUPAC_NAME [IUPAC]
synonym: "nitrogen mustards" RELATED [ChEBI]
xref: Wikipedia:Nitrogen_mustard
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent

[Term]
id: CHEBI:37622
name: carboxamide
namespace: chebi_ontology
alt_id: CHEBI:35354
alt_id: CHEBI:35355
def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." []
subset: 3_STAR
synonym: "carboxamides" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxamides" RELATED [ChEBI]
synonym: "primary carboxamide" RELATED [ChEBI]
is_a: CHEBI:33256 ! primary amide
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: BFO:0000051 CHEBI:23004 ! has part carbamoyl group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "42.01680" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)N([*])[*]" xsd:string

[Term]
id: CHEBI:37699
name: protein kinase inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases." []
subset: 3_STAR
synonym: "protein kinase inhibitors" RELATED [ChEBI]
is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor

[Term]
id: CHEBI:37808
name: butane
namespace: chebi_ontology
alt_id: CHEBI:22945
alt_id: CHEBI:25462
alt_id: CHEBI:44430
def: "A straight chain alkane composed of 4 carbon atoms." []
subset: 3_STAR
synonym: "butane" EXACT IUPAC_NAME [IUPAC]
synonym: "butane" EXACT [UniProt]
synonym: "E 943a" RELATED [ChEBI]
synonym: "E-943a" RELATED [ChEBI]
synonym: "E943a" RELATED [ChEBI]
synonym: "n-Butan" RELATED [ChEBI]
synonym: "N-BUTANE" RELATED [PDBeChem]
synonym: "n-butane" RELATED [NIST_Chemistry_WebBook]
synonym: "n-C4H10" RELATED [NIST_Chemistry_WebBook]
synonym: "R-600" RELATED [ChEBI]
xref: Beilstein:969129 {source="Beilstein"}
xref: CAS:106-97-8 {source="ChemIDplus"}
xref: CAS:106-97-8 {source="NIST Chemistry WebBook"}
xref: Gmelin:1148 {source="Gmelin"}
xref: PDBeChem:NBU
xref: PMID:24179026 {source="Europe PMC"}
xref: Reaxys:969129 {source="Reaxys"}
xref: Wikipedia:Butane
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:18310 ! alkane
relationship: RO:0000087 CHEBI:78017 ! has role food propellant
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H10" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H10/c1-3-4-2/h3-4H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IJDNQMDRQITEOD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "58.12220" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "58.07825" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCC" xsd:string

[Term]
id: CHEBI:37826
name: sulfuric acid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfuric acid derivative" EXACT [ChEBI]
synonym: "sulfuric acid derivatives" RELATED [ChEBI]
is_a: CHEBI:33424 ! sulfur oxoacid derivative
relationship: has_functional_parent CHEBI:26836 ! sulfuric acid

[Term]
id: CHEBI:37838
name: carboacyl group
namespace: chebi_ontology
def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." []
subset: 3_STAR
synonym: "carboacyl groups" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxylic acyl group" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxylic acyl groups" RELATED [IUPAC]
is_a: CHEBI:22221 ! acyl group
relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid

[Term]
id: CHEBI:37949
name: azacycloalkane
namespace: chebi_ontology
subset: 3_STAR
synonym: "azacycloalkanes" RELATED [ChEBI]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:37958
name: dye
namespace: chebi_ontology
subset: 3_STAR
synonym: "colorante" RELATED [ChEBI]
synonym: "colorantes" RELATED [ChEBI]
synonym: "dyes" RELATED [ChEBI]
synonym: "Farbstoff" RELATED [ChEBI]
synonym: "Farbstoffe" RELATED [ChEBI]
synonym: "teinture" RELATED [ChEBI]
synonym: "teintures" RELATED [ChEBI]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:37972
name: phosphorus-32 atom
namespace: chebi_ontology
def: "The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days." []
subset: 3_STAR
synonym: "(32)15P" RELATED [IUPAC]
synonym: "(32)P" RELATED [IUPAC]
synonym: "Phosphorus, isotope of mass 32" RELATED [KEGG_COMPOUND]
synonym: "phosphorus, isotope of mass 32" RELATED [ChemIDplus]
synonym: "phosphorus-32" EXACT IUPAC_NAME [IUPAC]
synonym: "phosphorus-32" RELATED [ChEBI]
xref: CAS:14596-37-3 {source="KEGG COMPOUND"}
xref: CAS:14596-37-3 {source="ChemIDplus"}
xref: KEGG:C19162
is_a: CHEBI:28659 ! phosphorus atom
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "[32P]" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/P/i1+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OAICVXFJPJFONN-OUBTZVSYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "31.974" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97391" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[32P]" xsd:string

[Term]
id: CHEBI:38032
name: carbotricyclic compound
namespace: chebi_ontology
def: "A carbopolyclic compound comprising of three carbocyclic rings." []
subset: 3_STAR
synonym: "carbotricyclic compounds" RELATED [ChEBI]
is_a: CHEBI:35294 ! carbopolycyclic compound
is_a: CHEBI:51959 ! organic tricyclic compound

[Term]
id: CHEBI:38034
name: aminonaphthalene
namespace: chebi_ontology
subset: 3_STAR
synonym: "aminonaphthalenes" RELATED [ChEBI]
is_a: CHEBI:25477 ! naphthalenes
is_a: CHEBI:33860 ! aromatic amine

[Term]
id: CHEBI:38037
name: methanesulfonate salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "mesylate salt" RELATED [ChEBI]
synonym: "mesylate salts" RELATED [ChEBI]
synonym: "methanesulfonate salts" RELATED [ChEBI]
is_a: CHEBI:48544 ! methanesulfonates
is_a: CHEBI:64382 ! organosulfonate salt

[Term]
id: CHEBI:38068
name: antimalarial
namespace: chebi_ontology
def: "A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human." []
subset: 3_STAR
synonym: "antimalarials" RELATED [ChEBI]
is_a: CHEBI:64915 ! antiplasmodial drug

[Term]
id: CHEBI:38101
name: organonitrogen heterocyclic compound
namespace: chebi_ontology
def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." []
subset: 3_STAR
synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI]
synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:38102
name: triazines
namespace: chebi_ontology
def: "Compounds based on a triazine skeleton." []
subset: 3_STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:50893 ! azaarene

[Term]
id: CHEBI:38104
name: oxacycle
namespace: chebi_ontology
def: "Any organic heterocyclic compound containing at least one ring oxygen atom." []
subset: 3_STAR
synonym: "heterocyclic organooxygen compounds" RELATED [ChEBI]
synonym: "organooxygen heterocyclic compounds" RELATED [ChEBI]
synonym: "oxacycles" RELATED [ChEBI]
xref: PMID:17134300 {source="Europe PMC"}
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:38106
name: organosulfur heterocyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "heterocyclic organosulfur compounds" RELATED [ChEBI]
synonym: "organosulfur heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33261 ! organosulfur compound

[Term]
id: CHEBI:38163
name: organic heterotetracyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic heterotetracyclic compounds" RELATED [ChEBI]
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:38166
name: organic heteropolycyclic compound
namespace: chebi_ontology
alt_id: CHEBI:25429
alt_id: CHEBI:38075
subset: 3_STAR
synonym: "organic heteropolycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33671 ! heteropolycyclic compound

[Term]
id: CHEBI:38175
name: triamino-1,3,5-triazine
namespace: chebi_ontology
subset: 3_STAR
synonym: "triamino-1,3,5-triazines" RELATED [ChEBI]
is_a: CHEBI:26588 ! 1,3,5-triazines

[Term]
id: CHEBI:38180
name: polycyclic heteroarene
namespace: chebi_ontology
subset: 3_STAR
synonym: "polycyclic heteroarenes" RELATED [ChEBI]
is_a: CHEBI:33833 ! heteroarene

[Term]
id: CHEBI:38234
name: DNA polymerase inhibitor
namespace: chebi_ontology
def: "Any inhibitor of a DNA polymerase." []
subset: 3_STAR
is_a: CHEBI:76815 ! EC 2.7.7.* (nucleotidyltransferase) inhibitor

[Term]
id: CHEBI:38303
name: azirinopyrroloindole
namespace: chebi_ontology
subset: 3_STAR
synonym: "azirinopyrroloindoles" RELATED [ChEBI]
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38163 ! organic heterotetracyclic compound

[Term]
id: CHEBI:38313
name: diazines
namespace: chebi_ontology
def: "Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure)." []
subset: 3_STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:38323
name: cholinergic drug
namespace: chebi_ontology
def: "Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons." []
subset: 3_STAR
synonym: "cholinergic agent" RELATED [ChEBI]
synonym: "cholinergic drugs" RELATED [ChEBI]
synonym: "cholinomimetic" RELATED [ChEBI]
is_a: CHEBI:35942 ! neurotransmitter agent

[Term]
id: CHEBI:38337
name: pyrimidone
namespace: chebi_ontology
def: "A pyrimidine carrying one or more oxo substituents." []
subset: 3_STAR
synonym: "pyrimidones" RELATED [ChEBI]
is_a: CHEBI:39447 ! pyrimidines

[Term]
id: CHEBI:38443
name: 1-benzopyran
namespace: chebi_ontology
subset: 3_STAR
synonym: "1-benzopyrans" RELATED [ChEBI]
is_a: CHEBI:22727 ! benzopyran

[Term]
id: CHEBI:38517
name: benzophenanthridine alkaloid
namespace: chebi_ontology
def: "A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family." []
subset: 3_STAR
synonym: "benzophenanthridine alkaloids" RELATED [ChEBI]
is_a: CHEBI:24921 ! isoquinoline alkaloid
is_a: CHEBI:38518 ! benzophenanthridine

[Term]
id: CHEBI:38518
name: benzophenanthridine
namespace: chebi_ontology
subset: 3_STAR
synonym: "benzophenanthridines" RELATED [ChEBI]
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:38632
name: membrane transport modulator
namespace: chebi_ontology
def: "Any agent that affects the transport of molecular entities across a biological membrane." []
subset: 3_STAR
synonym: "membrane transport modulators" RELATED [ChEBI]
is_a: CHEBI:52208 ! biophysical role

[Term]
id: CHEBI:38672
name: flavans
namespace: chebi_ontology
def: "Any flavonoid with a 3,4-dihydro-2-aryl-2H-1-benzopyran skeleton and its substituted derivatives." []
subset: 3_STAR
is_a: CHEBI:26004 ! phenylpropanoid
is_a: CHEBI:38443 ! 1-benzopyran
is_a: CHEBI:47916 ! flavonoid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C15OR14" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "196.160" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "195.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]c1c([*])c([*])c(c([*])c1[*])C1([*])Oc2c([*])c([*])c([*])c([*])c2C([*])([*])C1([*])[*]" xsd:string

[Term]
id: CHEBI:38702
name: inorganic sodium salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic sodium salts" RELATED [ChEBI]
is_a: CHEBI:24839 ! inorganic salt
is_a: CHEBI:26714 ! sodium salt

[Term]
id: CHEBI:38716
name: carboxylic acid dianion
namespace: chebi_ontology
def: "Any dianion containing at least one carboxy group." []
subset: 3_STAR
synonym: "carboxylic acid dianion" EXACT [ChEBI]
synonym: "carboxylic acid dianions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion

[Term]
id: CHEBI:38738
name: monomethoxyflavanone
namespace: chebi_ontology
def: "Any methoxyflavanone that is flavanone substituted by a methoxy group." []
subset: 3_STAR
synonym: "monomethoxyflavanones" RELATED [ChEBI]
is_a: CHEBI:25240 ! methoxyflavanone

[Term]
id: CHEBI:38739
name: trihydroxyflavanone
namespace: chebi_ontology
def: "A hydroxyflavanone carrying three hydroxy substituents." []
subset: 3_STAR
synonym: "trihydroxyflavanones" RELATED [ChEBI]
is_a: CHEBI:24697 ! hydroxyflavanone

[Term]
id: CHEBI:38749
name: dihydroxyflavanone
namespace: chebi_ontology
def: "Any  hydroxyflavanone carrying two hydroxy substituents." []
subset: 3_STAR
synonym: "dihydroxyflavanones" RELATED [ChEBI]
is_a: CHEBI:24697 ! hydroxyflavanone

[Term]
id: CHEBI:38780
name: N-nitro compound
namespace: chebi_ontology
def: "A compound having the nitro group (-NO2) attached to a nitrogen atom." []
subset: 3_STAR
synonym: "N-nitro compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:35715 ! nitro compound

[Term]
id: CHEBI:38793
name: pteroate
namespace: chebi_ontology
alt_id: CHEBI:37074
subset: 3_STAR
is_a: CHEBI:38796 ! pteroates
relationship: is_conjugate_base_of CHEBI:38794 ! pteroic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H11N6O3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "311.276" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "311.08926" xsd:string

[Term]
id: CHEBI:38794
name: pteroic acid
namespace: chebi_ontology
alt_id: CHEBI:26378
subset: 3_STAR
synonym: "Pteroic acid" EXACT [ChemIDplus]
synonym: "Pteroinsaeure" RELATED [ChEBI]
xref: CAS:119-24-4 {source="ChemIDplus"}
xref: DrugBank:DB04196
is_a: CHEBI:38795 ! pteroic acids
relationship: is_conjugate_acid_of CHEBI:38793 ! pteroate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H12N6O3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "312.284" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "312.09709" xsd:string

[Term]
id: CHEBI:38795
name: pteroic acids
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:26375 ! pterins

[Term]
id: CHEBI:38796
name: pteroates
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:22494 ! aminobenzoate

[Term]
id: CHEBI:38808
name: calcium channel modulator
namespace: chebi_ontology
def: "A membrane transport modulator that is able to regulate intracellular calcium levels." []
subset: 3_STAR
synonym: "calcium channel modulators" RELATED [ChEBI]
is_a: CHEBI:38632 ! membrane transport modulator

[Term]
id: CHEBI:38809
name: ryanodine receptor modulator
namespace: chebi_ontology
subset: 3_STAR
synonym: "ryanodine receptor modulators" RELATED [ChEBI]
synonym: "ryanodine-sensitive calcium channel modulator" RELATED [ChEBI]
synonym: "ryanodine-sensitive calcium-release channel modulator" RELATED [ChEBI]
synonym: "RyR modulator" RELATED [ChEBI]
is_a: CHEBI:38808 ! calcium channel modulator

[Term]
id: CHEBI:38867
name: anaesthetic
namespace: chebi_ontology
def: "Substance which produces loss of feeling or sensation." []
subset: 3_STAR
synonym: "anaesthetic" EXACT IUPAC_NAME [IUPAC]
synonym: "anaesthetics" RELATED [ChEBI]
synonym: "Anaesthetika" RELATED [ChEBI]
synonym: "Anaesthetikum" RELATED [ChEBI]
synonym: "anesthetic agent" RELATED [ChEBI]
synonym: "anesthetic drug" RELATED [ChEBI]
synonym: "anesthetics" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:38869
name: general anaesthetic
namespace: chebi_ontology
def: "Substance that produces loss of consciousness." []
subset: 3_STAR
synonym: "Allgemeinanaesthetika" RELATED [ChEBI]
synonym: "Allgemeinanaesthetikum" RELATED [ChEBI]
synonym: "general anaesthetic" EXACT IUPAC_NAME [IUPAC]
synonym: "general anaesthetics" RELATED [ChEBI]
synonym: "general anesthetics" RELATED [ChEBI]
is_a: CHEBI:38867 ! anaesthetic

[Term]
id: CHEBI:38870
name: inhalation anaesthetic
namespace: chebi_ontology
subset: 3_STAR
synonym: "anesthetic gases" RELATED [ChEBI]
synonym: "inhalation anesthetics" RELATED [ChEBI]
synonym: "Inhalationsanaesthetika" RELATED [ChEBI]
synonym: "Inhalationsanaesthetikum" RELATED [ChEBI]
synonym: "Inhalationsnarkotika" RELATED [ChEBI]
synonym: "Inhalationsnarkotikum" RELATED [ChEBI]
is_a: CHEBI:38869 ! general anaesthetic

[Term]
id: CHEBI:38941
name: schistosomicide drug
namespace: chebi_ontology
def: "Drugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma." []
subset: 3_STAR
synonym: "antischistosoma" RELATED [ChEBI]
synonym: "antischistosomal drug" RELATED [ChEBI]
synonym: "schistosomicide" RELATED [ChEBI]
synonym: "schistosomicide drugs" RELATED [ChEBI]
synonym: "schistosomicides" RELATED [ChEBI]
is_a: CHEBI:35684 ! antiplatyhelmintic drug

[Term]
id: CHEBI:38975
name: methylbenzene
namespace: chebi_ontology
def: "Any alkylbenzene that is benzene substituted with one or more methyl groups." []
subset: 3_STAR
synonym: "methylbenzenes" RELATED [ChEBI]
is_a: CHEBI:38976 ! alkylbenzene

[Term]
id: CHEBI:38976
name: alkylbenzene
namespace: chebi_ontology
def: "A  monocyclic arene that is benzene substituted with one or more alkyl groups." []
subset: 3_STAR
synonym: "alkylbenzene" EXACT [ChEBI]
synonym: "alkylbenzenes" RELATED [ChEBI]
synonym: "Alkylbenzol" RELATED [ChEBI]
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33847 ! monocyclic arene
relationship: has_parent_hydride CHEBI:16716 ! benzene

[Term]
id: CHEBI:39087
name: sulfurous acid derivative
namespace: chebi_ontology
def: "Any sulfur oxoacid derivative derived from sulfurous acid." []
subset: 3_STAR
synonym: "sulfurous acid derivative" EXACT [ChEBI]
is_a: CHEBI:33424 ! sulfur oxoacid derivative

[Term]
id: CHEBI:39141
name: Bronsted acid
namespace: chebi_ontology
def: "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." []
subset: 3_STAR
synonym: "acide de Bronsted" RELATED [IUPAC]
synonym: "Bronsted acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Bronsted-Saeure" RELATED [ChEBI]
synonym: "donneur d'hydron" RELATED [IUPAC]
synonym: "hydron donor" RELATED [IUPAC]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:37527 ! acid

[Term]
id: CHEBI:39142
name: Bronsted base
namespace: chebi_ontology
def: "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." []
subset: 3_STAR
synonym: "accepteur d'hydron" RELATED [IUPAC]
synonym: "base de Bronsted" RELATED [IUPAC]
synonym: "Bronsted base" EXACT IUPAC_NAME [IUPAC]
synonym: "Bronsted-Base" RELATED [ChEBI]
synonym: "hydron acceptor" RELATED [IUPAC]
is_a: CHEBI:15339 ! acceptor
is_a: CHEBI:22695 ! base

[Term]
id: CHEBI:39144
name: Lewis base
namespace: chebi_ontology
def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." []
subset: 3_STAR
synonym: "base de Lewis" RELATED [IUPAC]
synonym: "donneur d'une paire d'electrons" RELATED [ChEBI]
synonym: "electron donor" RELATED [ChEBI]
synonym: "Lewis base" EXACT IUPAC_NAME [IUPAC]
synonym: "Lewis-Base" RELATED [ChEBI]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:22695 ! base

[Term]
id: CHEBI:39179
name: nitroguanidine
namespace: chebi_ontology
def: "An N-nitro compound that is guanidine in which one of the hydrogens is replaced by a nitro group. It can exist in distinct tautomeric forms, as 1-nitroguanidine (a nitroimine) or 2-nitroguanidine (a nitroamine); in both solid and in solution, the nitroimine form predominates." []
subset: 3_STAR
synonym: "nitroguanidine" EXACT IUPAC_NAME [IUPAC]
synonym: "picrite" RELATED [NIST_Chemistry_WebBook]
xref: CAS:556-88-7 {source="ChemIDplus"}
xref: CAS:556-88-7 {source="NIST Chemistry WebBook"}
xref: Wikipedia:Nitroguanidine
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:38780 ! N-nitro compound
relationship: has_functional_parent CHEBI:42820 ! guanidine
relationship: has_functional_parent CHEBI:616459 ! carbamimidoylazanium
relationship: RO:0000087 CHEBI:63490 ! has role explosive
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4N4O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "104.068" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "104.03343" xsd:string

[Term]
id: CHEBI:39201
name: phenazines
namespace: chebi_ontology
def: "Any  organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives." []
subset: 3_STAR
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:39206
name: dibenzopyridine
namespace: chebi_ontology
subset: 3_STAR
synonym: "dibenzopyridines" RELATED [ChEBI]
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:39276
name: fumigant
namespace: chebi_ontology
def: "A volatile or volatilizable chemical compound utilized for control of pests in buildings, soil, grain, as well as during processing of goods to be imported or exported to prevent transfer of exotic organisms." []
subset: 3_STAR
synonym: "fumigant pesticide" RELATED [ChEBI]
synonym: "fumigants" RELATED [ChEBI]
xref: Wikipedia:Fumigation
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:39418
name: straight-chain saturated fatty acid
namespace: chebi_ontology
def: "Any saturated fatty acid lacking a side-chain." []
subset: 3_STAR
synonym: "straight-chain saturated fatty acid" EXACT [ChEBI]
synonym: "straight-chain saturated fatty acids" RELATED [ChEBI]
xref: PMID:15644336 {source="Europe PMC"}
is_a: CHEBI:26607 ! saturated fatty acid
is_a: CHEBI:59202 ! straight-chain fatty acid
relationship: is_conjugate_acid_of CHEBI:58954 ! straight-chain saturated fatty acid anion

[Term]
id: CHEBI:39446
name: pyrimidine ribonucleosides
namespace: chebi_ontology
alt_id: CHEBI:13784
alt_id: CHEBI:26445
alt_id: CHEBI:7263
subset: 3_STAR
is_a: CHEBI:18254 ! ribonucleoside
is_a: CHEBI:26440 ! pyrimidine nucleoside

[Term]
id: CHEBI:39447
name: pyrimidines
namespace: chebi_ontology
alt_id: CHEBI:13681
alt_id: CHEBI:26448
def: "Any compound having a pyrimidine as part of its structure." []
subset: 3_STAR
is_a: CHEBI:38313 ! diazines

[Term]
id: CHEBI:39745
name: dihydrogenphosphate
namespace: chebi_ontology
alt_id: CHEBI:29137
alt_id: CHEBI:39739
def: "A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated." []
subset: 3_STAR
synonym: "[PO2(OH)2](-)" RELATED [IUPAC]
synonym: "dihydrogen(tetraoxidophosphate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydrogenphosphate" EXACT IUPAC_NAME [IUPAC]
synonym: "DIHYDROGENPHOSPHATE ION" RELATED [PDBeChem]
synonym: "dihydrogentetraoxophosphate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydrogentetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydroxidodioxidophosphate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "H2PO4(-)" RELATED [IUPAC]
xref: DrugBank:DB02831
xref: Gmelin:1999 {source="Gmelin"}
xref: PDBeChem:2HP
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: is_conjugate_acid_of CHEBI:43474 ! hydrogenphosphate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.98724" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.96962" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP([O-])(=O)O[H]" xsd:string

[Term]
id: CHEBI:3992
name: cyclic ketone
namespace: chebi_ontology
subset: 3_STAR
synonym: "Cyclic ketone" EXACT [KEGG_COMPOUND]
synonym: "cyclic ketones" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C02019
is_a: CHEBI:17087 ! ketone

[Term]
id: CHEBI:41189
name: butane-1,4-diol
namespace: chebi_ontology
def: "A butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16degreeC) with a high boiling point (230degreeC), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF)." []
subset: 3_STAR
synonym: "1,4-BD" RELATED [ChemIDplus]
synonym: "1,4-BUTANEDIOL" RELATED [PDBeChem]
synonym: "1,4-butylene glycol" RELATED [ChemIDplus]
synonym: "1,4-dihydroxybutane" RELATED [ChemIDplus]
synonym: "1,4-tetramethylene glycol" RELATED [ChemIDplus]
synonym: "butane-1,4-diol" EXACT IUPAC_NAME [IUPAC]
synonym: "HO(CH2)4OH" RELATED [ChEBI]
synonym: "HOCH2CH2CH2CH2OH" RELATED [ChEBI]
synonym: "tetramethylene 1,4-diol" RELATED [ChemIDplus]
synonym: "tetramethylene glycol" RELATED [ChemIDplus]
xref: CAS:110-63-4 {source="ChemIDplus"}
xref: CAS:110-63-4 {source="NIST Chemistry WebBook"}
xref: DrugBank:DB01955
xref: PDBeChem:BU1
xref: PMID:11803699 {source="Europe PMC"}
xref: PMID:15298490 {source="Europe PMC"}
xref: PMID:16193534 {source="Europe PMC"}
xref: PMID:17854202 {source="Europe PMC"}
xref: PMID:18203723 {source="Europe PMC"}
xref: PMID:19915428 {source="Europe PMC"}
xref: PMID:20112336 {source="Europe PMC"}
xref: PMID:21548140 {source="Europe PMC"}
xref: PMID:21602812 {source="Europe PMC"}
xref: Reaxys:1633445 {source="Reaxys"}
xref: Wikipedia:1\,4-Butanediol
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:13643 ! glycol
is_a: CHEBI:52684 ! butanediol
relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
relationship: RO:0000087 CHEBI:50266 ! has role prodrug
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H10O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H10O2/c5-3-1-2-4-6/h5-6H,1-4H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WERYXYBDKMZEQL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "90.12100" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "90.06808" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OCCCCO" xsd:string

[Term]
id: CHEBI:41609
name: carbonate
namespace: chebi_ontology
alt_id: CHEBI:29201
alt_id: CHEBI:41605
subset: 3_STAR
synonym: "[CO3](2-)" RELATED [IUPAC]
synonym: "carbonate" EXACT [IUPAC]
synonym: "CARBONATE ION" RELATED [PDBeChem]
synonym: "CO3(2-)" RELATED [ChEBI]
synonym: "Karbonat" RELATED [ChEBI]
synonym: "trioxidocarbonate(2-)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3600898 {source="Beilstein"}
xref: CAS:3812-32-6 {source="ChemIDplus"}
xref: Gmelin:1559 {source="Gmelin"}
xref: PDBeChem:CO3
is_a: CHEBI:35604 ! carbon oxoanion
relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.00890" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.98584" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([O-])=O" xsd:string

[Term]
id: CHEBI:42266
name: ethane
namespace: chebi_ontology
alt_id: CHEBI:23975
alt_id: CHEBI:42260
def: "An alkane comprising of two carbon atoms." []
subset: 3_STAR
synonym: "Aethan" RELATED [ChEBI]
synonym: "bimethyl" RELATED [NIST_Chemistry_WebBook]
synonym: "C2H6" RELATED [ChEBI]
synonym: "CH3-CH3" RELATED [IUPAC]
synonym: "dimethyl" RELATED [NIST_Chemistry_WebBook]
synonym: "Ethan" RELATED [ChEBI]
synonym: "ETHANE" EXACT [PDBeChem]
synonym: "ethane" EXACT IUPAC_NAME [IUPAC]
synonym: "ethyl hydride" RELATED [NIST_Chemistry_WebBook]
synonym: "methylmethane" RELATED [NIST_Chemistry_WebBook]
synonym: "R-170" RELATED [ChEBI]
xref: Beilstein:1730716 {source="Beilstein"}
xref: CAS:74-84-0 {source="ChemIDplus"}
xref: CAS:74-84-0 {source="NIST Chemistry WebBook"}
xref: Gmelin:212 {source="Gmelin"}
xref: PMID:12826252 {source="Europe PMC"}
xref: PMID:14664856 {source="Europe PMC"}
xref: PMID:16236899 {source="Europe PMC"}
xref: Reaxys:1730716 {source="Reaxys"}
xref: Wikipedia:Ethane
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:18310 ! alkane
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H6/c1-2/h1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OTMSDBZUPAUEDD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "30.06904" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.04695" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC" xsd:string

[Term]
id: CHEBI:42485
name: formyl group
namespace: chebi_ontology
alt_id: CHEBI:24089
alt_id: CHEBI:42480
subset: 3_STAR
synonym: "-CH(O)" RELATED [IUPAC]
synonym: "-CHO" RELATED [IUPAC]
synonym: "aldehyde group" EXACT IUPAC_NAME [IUPAC]
synonym: "carbaldehyde" EXACT IUPAC_NAME [IUPAC]
synonym: "Fo" RELATED [CBN]
synonym: "formyl" EXACT IUPAC_NAME [IUPAC]
synonym: "FORMYL GROUP" EXACT [PDBeChem]
synonym: "H-CO-" RELATED [IUPAC]
synonym: "methanoyl" RELATED [IUPAC]
xref: PDBeChem:FOR
is_a: CHEBI:27207 ! univalent carboacyl group
relationship: is_substituent_group_from CHEBI:30751 ! formic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "29.01804" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.00274" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(*)=O" xsd:string

[Term]
id: CHEBI:42820
name: guanidine
namespace: chebi_ontology
alt_id: CHEBI:24435
alt_id: CHEBI:42816
def: "An aminocarboxamidine, the parent compound of the guanidines." []
subset: 3_STAR
synonym: "aminomethanamidine" RELATED [NIST_Chemistry_WebBook]
synonym: "Gu" RELATED [ChEBI]
synonym: "guanidin" RELATED [ChEBI]
synonym: "GUANIDINE" EXACT [PDBeChem]
synonym: "guanidine" EXACT IUPAC_NAME [IUPAC]
synonym: "H2N-C(=NH)-NH2" RELATED [IUPAC]
synonym: "iminourea" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:506044 {source="Beilstein"}
xref: CAS:113-00-8 {source="ChemIDplus"}
xref: CAS:113-00-8 {source="NIST Chemistry WebBook"}
xref: Drug_Central:1344 {source="DrugCentral"}
xref: DrugBank:DB00536
xref: Gmelin:100679 {source="Gmelin"}
xref: PDBeChem:GAI
xref: PMID:8070089 {source="Europe PMC"}
xref: Reaxys:506044 {source="Reaxys"}
xref: Wikipedia:Guanidine
is_a: CHEBI:24436 ! guanidines
is_a: CHEBI:35359 ! carboxamidine
is_a: CHEBI:64708 ! one-carbon compound
relationship: is_conjugate_base_of CHEBI:30087 ! guanidinium
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH5N3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZRALSGWEFCBTJO-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "59.07062" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.04835" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(N)=N" xsd:string

[Term]
id: CHEBI:43176
name: hydroxy group
namespace: chebi_ontology
alt_id: CHEBI:24706
alt_id: CHEBI:43171
subset: 3_STAR
synonym: "-OH" RELATED [IUPAC]
synonym: "hydroxy" EXACT IUPAC_NAME [IUPAC]
synonym: "HYDROXY GROUP" EXACT [PDBeChem]
synonym: "hydroxy group" EXACT [UniProt]
synonym: "hydroxyl" RELATED [ChEBI]
synonym: "hydroxyl group" RELATED [ChEBI]
xref: PDBeChem:OH
is_a: CHEBI:33246 ! inorganic group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "17.00734" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*O[H]" xsd:string

[Term]
id: CHEBI:43254
name: (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:38337 ! pyrimidone
relationship: is_tautomer_of CHEBI:17568 ! uracil

[Term]
id: CHEBI:43474
name: hydrogenphosphate
namespace: chebi_ontology
alt_id: CHEBI:29139
alt_id: CHEBI:43470
def: "A phosphate ion that is the conjugate base of dihydrogenphosphate." []
subset: 3_STAR
synonym: "[P(OH)O3](2-)" RELATED [MolBase]
synonym: "[PO3(OH)](2-)" RELATED [IUPAC]
synonym: "HPO4(2-)" RELATED [IUPAC]
synonym: "hydrogen phosphate" RELATED [ChEBI]
synonym: "hydrogen(tetraoxidophosphate)(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogenphosphate" EXACT IUPAC_NAME [IUPAC]
synonym: "HYDROGENPHOSPHATE ION" RELATED [PDBeChem]
synonym: "hydrogentetraoxophosphate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxidotrioxidophosphate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "INORGANIC PHOSPHATE GROUP" RELATED [PDBeChem]
synonym: "phosphate" RELATED [UniProt]
xref: Gmelin:1998 {source="Gmelin"}
xref: MolBase:1628
xref: PDBeChem:PI
xref: PDBeChem:PO4
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: is_conjugate_acid_of CHEBI:18367 ! phosphate(3-)
relationship: is_conjugate_base_of CHEBI:39745 ! dihydrogenphosphate
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "95.97930" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.96234" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OP([O-])([O-])=O" xsd:string

[Term]
id: CHEBI:45696
name: hydrogensulfate
namespace: chebi_ontology
alt_id: CHEBI:29199
alt_id: CHEBI:45693
subset: 3_STAR
synonym: "[SO3(OH)](-)" RELATED [IUPAC]
synonym: "HSO4(-)" RELATED [IUPAC]
synonym: "HYDROGEN SULFATE" RELATED [PDBeChem]
synonym: "hydrogen(tetraoxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogensulfate" EXACT [IUPAC]
synonym: "hydrogensulfate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentetraoxosulfate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxidotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC]
xref: Gmelin:2121 {source="Gmelin"}
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate
relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "97.07154" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.96010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OS([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:46629
name: oxo group
namespace: chebi_ontology
alt_id: CHEBI:29353
alt_id: CHEBI:44607
subset: 3_STAR
synonym: "=O" RELATED [IUPAC]
synonym: "oxo" EXACT IUPAC_NAME [IUPAC]
synonym: "OXO GROUP" EXACT [PDBeChem]
xref: PDBeChem:O
is_a: CHEBI:33246 ! inorganic group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=*" xsd:string

[Term]
id: CHEBI:46787
name: solvent
namespace: chebi_ontology
def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." []
subset: 3_STAR
synonym: "Loesungsmittel" RELATED [ChEBI]
synonym: "solvant" RELATED [ChEBI]
synonym: "solvents" RELATED [ChEBI]
xref: Wikipedia:Solvent
is_a: CHEBI:33232 ! application
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:46789
name: hydroxyether
namespace: chebi_ontology
def: "Any ether carrying a hydroxy group at unspecified position." []
subset: 3_STAR
synonym: "hydroxyether" EXACT [ChEBI]
is_a: CHEBI:25698 ! ether
is_a: CHEBI:30879 ! alcohol

[Term]
id: CHEBI:46790
name: 2-methoxyethanol
namespace: chebi_ontology
alt_id: CHEBI:19677
alt_id: CHEBI:44217
def: "A hydroxyether that is ethanol substituted by a methoxy group at position 2." []
subset: 3_STAR
synonym: "1-hydroxy-2-methoxyethane" RELATED [ChemIDplus]
synonym: "2-hydroxyethyl methyl ether" RELATED [NIST_Chemistry_WebBook]
synonym: "2-methoxy-1-ethanol" RELATED [ChemIDplus]
synonym: "2-METHOXYETHANOL" EXACT [PDBeChem]
synonym: "2-methoxyethanol" EXACT IUPAC_NAME [IUPAC]
synonym: "3-oxa-1-butanol" RELATED [ChemIDplus]
synonym: "beta-methoxyethanol" RELATED [NIST_Chemistry_WebBook]
synonym: "HOCH2CH2OCH3" RELATED [NIST_Chemistry_WebBook]
synonym: "Methyl cellosolve" RELATED [ChemIDplus]
synonym: "methyl oxitol" RELATED [ChemIDplus]
synonym: "monomethyl ethylene glycol ether" RELATED [ChemIDplus]
xref: Beilstein:1731074 {source="ChemIDplus"}
xref: CAS:109-86-4 {source="ChemIDplus"}
xref: CAS:109-86-4 {source="NIST Chemistry WebBook"}
xref: DrugBank:DB02806
xref: Gmelin:81877 {source="Gmelin"}
xref: MetaCyc:2-METHOXYETHANOL
xref: PDBeChem:MXE
xref: PMID:11354470 {source="Europe PMC"}
xref: PMID:24399739 {source="Europe PMC"}
xref: PPDB:1639
xref: Reaxys:1731074 {source="Reaxys"}
xref: Wikipedia:2-Methoxyethanol
is_a: CHEBI:172390 ! glycol ether
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H8O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XNWFRZJHXBZDAG-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "76.09442" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "76.05243" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COCCO" xsd:string

[Term]
id: CHEBI:46883
name: carboxy group
namespace: chebi_ontology
alt_id: CHEBI:23025
alt_id: CHEBI:41420
subset: 3_STAR
synonym: "-C(O)OH" RELATED [IUPAC]
synonym: "-CO2H" RELATED [ChEBI]
synonym: "-COOH" RELATED [IUPAC]
synonym: "carboxy" EXACT IUPAC_NAME [IUPAC]
synonym: "CARBOXY GROUP" EXACT [PDBeChem]
synonym: "carboxyl group" RELATED [ChEBI]
xref: PDBeChem:FMT
is_a: CHEBI:33249 ! organyl group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01744" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(=O)O" xsd:string

[Term]
id: CHEBI:47017
name: tetrahydrofuranol
namespace: chebi_ontology
subset: 3_STAR
synonym: "tetrahydrofuranols" RELATED [ChEBI]
is_a: CHEBI:26912 ! oxolanes

[Term]
id: CHEBI:47018
name: monohydroxytetrahydrofuran
namespace: chebi_ontology
subset: 3_STAR
synonym: "monohydroxytetrahydrofurans" RELATED [ChEBI]
is_a: CHEBI:47017 ! tetrahydrofuranol

[Term]
id: CHEBI:47019
name: dihydroxytetrahydrofuran
namespace: chebi_ontology
subset: 3_STAR
synonym: "dihydroxytetrahydrofurans" RELATED [ChEBI]
is_a: CHEBI:47017 ! tetrahydrofuranol

[Term]
id: CHEBI:47857
name: ureas
namespace: chebi_ontology
alt_id: CHEBI:27220
alt_id: CHEBI:36947
subset: 3_STAR
synonym: "urea derivatives" RELATED [ChEBI]
is_a: CHEBI:33256 ! primary amide
relationship: has_functional_parent CHEBI:16199 ! urea

[Term]
id: CHEBI:47868
name: photosensitizing agent
namespace: chebi_ontology
def: "A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells." []
subset: 3_STAR
synonym: "photosensitising agent" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:47901
name: alkanesulfonic acid
namespace: chebi_ontology
alt_id: CHEBI:13809
alt_id: CHEBI:33553
def: "Organic derivatives of sulfonic acid in which the sulfo group is linked directly to carbon of an alkyl group." []
subset: 3_STAR
synonym: "alkanesulfonic acids" RELATED [ChEBI]
synonym: "alkylsulfonic acids" RELATED [ChEBI]
is_a: CHEBI:33551 ! organosulfonic acid
relationship: BFO:0000051 CHEBI:22323 ! has part alkyl group

[Term]
id: CHEBI:47916
name: flavonoid
namespace: chebi_ontology
alt_id: CHEBI:13638
alt_id: CHEBI:24044
alt_id: CHEBI:5077
def: "Any member of the 'superclass' flavonoids whose skeleton is based on 1-benzopyran with an aryl substituent at position 2. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds." []
subset: 3_STAR
synonym: "2-aryl-1-benzopyran" RELATED [ChEBI]
synonym: "2-aryl-1-benzopyrans" RELATED [ChEBI]
synonym: "Flavonoid" EXACT [KEGG_COMPOUND]
synonym: "flavonoids" RELATED [ChEBI]
xref: KEGG:C01579
xref: Wikipedia:Flavonoid
is_a: CHEBI:72544 ! flavonoids
relationship: has_functional_parent CHEBI:26004 ! phenylpropanoid
relationship: has_functional_parent CHEBI:38443 ! 1-benzopyran
relationship: is_conjugate_acid_of CHEBI:60038 ! flavonoid oxoanion

[Term]
id: CHEBI:48024
name: 3'-hydroxyflavanones
namespace: chebi_ontology
def: "Any hydroxyflavanone with a hydroxy substituent at position 3' of the phenyl ring." []
subset: 3_STAR
xref: MetaCyc:3-Hydroxy-Flavanones
is_a: CHEBI:24697 ! hydroxyflavanone

[Term]
id: CHEBI:48154
name: sulfur oxide
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxides of sulfur" RELATED [ChEBI]
synonym: "Schwefeloxide" RELATED [ChEBI]
synonym: "sulfur oxides" RELATED [ChEBI]
is_a: CHEBI:24836 ! inorganic oxide
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:48219
name: disinfectant
namespace: chebi_ontology
def: "An antimicrobial agent that is applied to non-living objects to destroy harmful microorganisms or to inhibit their activity." []
subset: 3_STAR
synonym: "desinfectant" RELATED [ChEBI]
synonym: "Desinfektionsmittel" RELATED [ChEBI]
synonym: "disinfectants" RELATED [ChEBI]
synonym: "disinfecting agent" RELATED [ChEBI]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:48354
name: polar solvent
namespace: chebi_ontology
def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." []
subset: 3_STAR
synonym: "polar solvent" EXACT IUPAC_NAME [IUPAC]
synonym: "polar solvents" RELATED [ChEBI]
is_a: CHEBI:46787 ! solvent

[Term]
id: CHEBI:48355
name: non-polar solvent
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:46787 ! solvent

[Term]
id: CHEBI:48356
name: protic solvent
namespace: chebi_ontology
def: "A polar solvent that is capable of acting as a hydron (proton) donor." []
subset: 3_STAR
synonym: "protogenic solvent" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:39141 ! Bronsted acid
is_a: CHEBI:48354 ! polar solvent

[Term]
id: CHEBI:48357
name: aprotic solvent
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:46787 ! solvent

[Term]
id: CHEBI:48358
name: polar aprotic solvent
namespace: chebi_ontology
def: "A solvent with a comparatively high relative permittivity (or dielectric constant), greater than ca. 15, and a sizable permanent dipole moment, that cannot donate suitably labile hydrogen atoms to form strong hydrogen bonds." []
subset: 3_STAR
synonym: "dipolar aprotic solvent" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:48354 ! polar solvent
is_a: CHEBI:48357 ! aprotic solvent

[Term]
id: CHEBI:48376
name: carbamimidic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbamimic acid" RELATED [ChemIDplus]
synonym: "carbamimidic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "carbonamidimidic acid" RELATED [IUPAC]
synonym: "H2N-C(=NH)-OH" RELATED [IUPAC]
synonym: "H2N-C(OH)=NH" RELATED [IUPAC]
synonym: "HO-C(=NH)-NH2" RELATED [IUPAC]
synonym: "Isoharnstoff" RELATED [ChEBI]
synonym: "isourea" RELATED [ChemIDplus]
synonym: "pseudourea" RELATED [ChemIDplus]
xref: Beilstein:773698 {source="Beilstein"}
xref: CAS:4744-36-9 {source="ChemIDplus"}
is_a: CHEBI:48379 ! isourea
is_a: CHEBI:64708 ! one-carbon compound
relationship: is_tautomer_of CHEBI:16199 ! urea
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4N2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XSQUKJJJFZCRTK-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.05534" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.03236" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(O)=N" xsd:string

[Term]
id: CHEBI:48377
name: imidic acid
namespace: chebi_ontology
def: "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH)." []
subset: 3_STAR
synonym: "imidic acid" EXACT [ChEBI]
synonym: "imidic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "imidic acids" RELATED [ChEBI]
synonym: "imino acids" RELATED [IUPAC]
is_a: CHEBI:33241 ! oxoacid derivative
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:48378
name: carboximidic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "carboximidic acid" EXACT [ChEBI]
synonym: "carboximidic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "carboximidic acids" RELATED [ChEBI]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:48377 ! imidic acid

[Term]
id: CHEBI:48379
name: isourea
namespace: chebi_ontology
def: "A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives." []
subset: 3_STAR
synonym: "isoureas" EXACT IUPAC_NAME [IUPAC]
synonym: "isoureas" RELATED [ChEBI]
is_a: CHEBI:48378 ! carboximidic acid

[Term]
id: CHEBI:48544
name: methanesulfonates
namespace: chebi_ontology
def: "Esters or salts of methanesulfonic acid." []
subset: 3_STAR
is_a: CHEBI:33261 ! organosulfur compound
relationship: has_functional_parent CHEBI:27376 ! methanesulfonic acid

[Term]
id: CHEBI:48578
name: radical scavenger
namespace: chebi_ontology
def: "A role played by a substance that can react readily with, and thereby eliminate, radicals." []
subset: 3_STAR
synonym: "free radical scavengers" RELATED [ChEBI]
synonym: "free-radical scavenger" RELATED [ChEBI]
is_a: CHEBI:22586 ! antioxidant

[Term]
id: CHEBI:48706
name: antagonist
namespace: chebi_ontology
def: "Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances." []
subset: 3_STAR
synonym: "antagonist" EXACT IUPAC_NAME [IUPAC]
synonym: "antagonista" RELATED [ChEBI]
synonym: "antagoniste" RELATED [ChEBI]
synonym: "antagonists" RELATED [ChEBI]
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:48854
name: sulfurous acid
namespace: chebi_ontology
alt_id: CHEBI:26837
alt_id: CHEBI:9344
subset: 3_STAR
synonym: "[SO(OH)2]" RELATED [IUPAC]
synonym: "acide sulfureux" RELATED [ChEBI]
synonym: "acido sulfuroso" RELATED [ChEBI]
synonym: "dihydrogen trioxosulfate" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydroxidooxidosulfur" EXACT IUPAC_NAME [IUPAC]
synonym: "H2SO3" RELATED [IUPAC]
synonym: "S(O)(OH)2" RELATED [IUPAC]
synonym: "schweflige Saeure" RELATED [ChemIDplus]
synonym: "Sulfite" RELATED [KEGG_COMPOUND]
synonym: "Sulfurous acid" EXACT [KEGG_COMPOUND]
synonym: "sulfurous acid" EXACT IUPAC_NAME [IUPAC]
synonym: "sulphurous acid" RELATED [ChemIDplus]
synonym: "trioxosulfuric acid" EXACT IUPAC_NAME [IUPAC]
xref: CAS:7782-99-2 {source="ChemIDplus"}
xref: Gmelin:1458 {source="Gmelin"}
xref: KEGG:C00094
xref: KNApSAcK:C00019662
xref: PDBeChem:SO3
xref: UM-BBD_compID:c0348 {source="UM-BBD"}
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: is_conjugate_acid_of CHEBI:17137 ! hydrogensulfite
relationship: is_tautomer_of CHEBI:29214 ! sulfonic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "82.08008" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.97247" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS(O)=O" xsd:string

[Term]
id: CHEBI:48857
name: sulfite salt
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:24839 ! inorganic salt
is_a: CHEBI:26823 ! sulfites

[Term]
id: CHEBI:48873
name: cholinergic antagonist
namespace: chebi_ontology
def: "Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists." []
subset: 3_STAR
synonym: "acetylcholine antagonists" RELATED [ChEBI]
synonym: "acetylcholine receptor antagonist" RELATED [IUPHAR]
synonym: "agent anticholinergique" RELATED [ChEBI]
synonym: "agente anticolinergico" RELATED [ChEBI]
synonym: "agentes anticolinergicos" RELATED [ChEBI]
synonym: "anticholinergic agents" RELATED [ChEBI]
synonym: "anticholinergics" RELATED [ChEBI]
synonym: "Anticholinergika" RELATED [ChEBI]
synonym: "Anticholinergikum" RELATED [ChEBI]
synonym: "anticholinergiques" RELATED [ChEBI]
synonym: "anticolinergicos" RELATED [ChEBI]
synonym: "cholinergic-blocking agents" RELATED [ChEBI]
is_a: CHEBI:38323 ! cholinergic drug

[Term]
id: CHEBI:48927
name: N-acyl-L-alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:13240
alt_id: CHEBI:7232
def: "Any L-alpha-amino acid carrying an N-acyl substituent." []
subset: 3_STAR
synonym: "N-Acyl-L-amino acid" RELATED [KEGG_COMPOUND]
xref: KEGG:C02850
is_a: CHEBI:21644 ! N-acyl-L-amino acid
relationship: has_functional_parent CHEBI:15705 ! L-alpha-amino acid
relationship: is_conjugate_acid_of CHEBI:59874 ! N-acyl-L-alpha-amino acid anion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H3NO3R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "101.061" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.01129" xsd:string

[Term]
id: CHEBI:49637
name: hydrogen atom
namespace: chebi_ontology
alt_id: CHEBI:24634
alt_id: CHEBI:49636
subset: 3_STAR
synonym: "1H" RELATED [IUPAC]
synonym: "H" RELATED [IUPAC]
synonym: "hidrogeno" RELATED [ChEBI]
synonym: "hydrogen" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogen" RELATED [ChEBI]
synonym: "hydrogene" RELATED [ChEBI]
synonym: "Wasserstoff" RELATED [ChEBI]
xref: WebElements:H
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33559 ! s-block element atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YZCKVEUIGOORGS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "1.00794" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.00783" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]" xsd:string

[Term]
id: CHEBI:50047
name: organic amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." []
subset: 3_STAR
synonym: "organic amino compounds" RELATED [ChEBI]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35352 ! organonitrogen compound
relationship: has_parent_hydride CHEBI:16134 ! ammonia
relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base

[Term]
id: CHEBI:50102
name: N-methyl-N-nitrosourea
namespace: chebi_ontology
alt_id: CHEBI:25565
alt_id: CHEBI:34843
alt_id: CHEBI:50101
def: "A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups." []
subset: 3_STAR
synonym: "1-(aminocarbonyl)-1-methyl-2-oxohydrazine" RELATED [NIST_Chemistry_WebBook]
synonym: "1-methyl-1-nitrosourea" EXACT IUPAC_NAME [IUPAC]
synonym: "1-nitroso-1-methylurea" RELATED [ChemIDplus]
synonym: "Methylnitrosoharnstoff" RELATED [ChEBI]
synonym: "Methylnitrosourea" RELATED [KEGG_COMPOUND]
synonym: "methylnitrosouree" RELATED [ChemIDplus]
synonym: "MNU" RELATED [ChemIDplus]
synonym: "N-methyl-N-nitrosocarbamide" RELATED [ChemIDplus]
synonym: "N-Methyl-N-nitrosoharnstoff" RELATED [ChEBI]
synonym: "N-Methyl-N-nitrosourea" EXACT [KEGG_COMPOUND]
synonym: "N-methyl-N-nitrosouree" RELATED [ChEBI]
synonym: "N-nitroso-N-methylcarbamide" RELATED [NIST_Chemistry_WebBook]
synonym: "N-Nitroso-N-methylharnstoff" RELATED [ChEBI]
synonym: "N-nitroso-N-methylurea" RELATED [ChemIDplus]
synonym: "N-nitroso-N-methyluree" RELATED [ChEBI]
synonym: "N-nitrosomethylurea" RELATED [NIST_Chemistry_WebBook]
synonym: "nitrosomethylurea" RELATED [NIST_Chemistry_WebBook]
synonym: "NMH" RELATED [ChemIDplus]
synonym: "NMU" RELATED [ChemIDplus]
xref: Beilstein:1756040 {source="Beilstein"}
xref: CAS:684-93-5 {source="KEGG COMPOUND"}
xref: CAS:684-93-5 {source="NIST Chemistry WebBook"}
xref: CAS:684-93-5 {source="ChemIDplus"}
xref: KEGG:C14595
xref: PMID:11479921 {source="Europe PMC"}
xref: PMID:12767522 {source="Europe PMC"}
xref: PMID:15990165 {source="Europe PMC"}
xref: PMID:19181008 {source="Europe PMC"}
xref: PMID:24441676 {source="Europe PMC"}
xref: PMID:6243984 {source="Europe PMC"}
xref: PMID:8098217 {source="Europe PMC"}
xref: PMID:8603364 {source="Europe PMC"}
xref: Wikipedia:N-Methyl-N-nitrosourea
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:76551 ! N-nitrosoureas
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:50905 ! has role teratogenic agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H5N3O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZRKWMRDKSOPRRS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "103.08012" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "103.03818" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(N=O)C(N)=O" xsd:string

[Term]
id: CHEBI:50218
name: EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:76774
def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a phosphoric diester hydrolase (EC 3.1.4.*)." []
subset: 3_STAR
synonym: "EC 3.1.4.* (phosphoric diester hydrolase) inhibitors" RELATED [ChEBI]
synonym: "phosphodiesterase inhibitor" RELATED [ChEBI]
synonym: "phosphodiesterase inhibitors" RELATED [ChEBI]
synonym: "phosphoric diester hydrolase (EC 3.1.4.*) inhibitor" RELATED [ChEBI]
synonym: "phosphoric diester hydrolase (EC 3.1.4.*) inhibitors" RELATED [ChEBI]
synonym: "phosphoric diester hydrolase inhibitor" RELATED [ChEBI]
synonym: "phosphoric diester hydrolase inhibitors" RELATED [ChEBI]
is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor

[Term]
id: CHEBI:50247
name: antidote
namespace: chebi_ontology
def: "Any protective agent counteracting or neutralizing the action of poisons." []
subset: 3_STAR
synonym: "antidotes" RELATED [ChEBI]
is_a: CHEBI:50267 ! protective agent

[Term]
id: CHEBI:50266
name: prodrug
namespace: chebi_ontology
def: "A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug." []
subset: 3_STAR
synonym: "Prodrugs" RELATED [ChEBI]
xref: PMID:23993918 {source="Europe PMC"}
xref: PMID:23998799 {source="Europe PMC"}
xref: PMID:24329110 {source="Europe PMC"}
xref: PMID:24628402 {source="Europe PMC"}
xref: PMID:24709544 {source="Europe PMC"}
xref: PMID:25144792 {source="Europe PMC"}
xref: PMID:25157234 {source="Europe PMC"}
xref: PMID:25269430 {source="Europe PMC"}
xref: PMID:25391982 {source="Europe PMC"}
xref: PMID:25591121 {source="Europe PMC"}
xref: PMID:25620096 {source="Europe PMC"}
xref: PMID:25795057 {source="Europe PMC"}
xref: PMID:26028253 {source="Europe PMC"}
xref: PMID:26184144 {source="Europe PMC"}
xref: PMID:28070577 {source="Europe PMC"}
xref: PMID:28215138 {source="Europe PMC"}
xref: PMID:28219047 {source="Europe PMC"}
xref: PMID:28259775 {source="Europe PMC"}
xref: PMID:28319647 {source="Europe PMC"}
xref: PMID:28329729 {source="Europe PMC"}
xref: PMID:28334528 {source="Europe PMC"}
xref: Wikipedia:Prodrug
is_a: CHEBI:136859 ! pro-agent
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50267
name: protective agent
namespace: chebi_ontology
def: "Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent." []
subset: 3_STAR
synonym: "chemoprotectant" RELATED [ChEBI]
synonym: "chemoprotectants" RELATED [ChEBI]
synonym: "chemoprotective agent" RELATED [ChEBI]
synonym: "chemoprotective agents" RELATED [ChEBI]
synonym: "protective agents" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50276
name: EC 5.99.1.2 (DNA topoisomerase) inhibitor
namespace: chebi_ontology
def: "A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA." []
subset: 3_STAR
synonym: "DNA topoisomerase inhibitor" RELATED [ChEBI]
synonym: "DNA topoisomerase inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.1.2 (DNA topoisomerase) inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.1.2 (topoisomerase I) inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.1.2 (topoisomerase I) inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.1.2 inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.1.2 inhibitors" RELATED [ChEBI]
synonym: "topoisomerase I (EC 5.99.1.2) inhibitor" RELATED [ChEBI]
synonym: "topoisomerase I (EC 5.99.1.2) inhibitors" RELATED [ChEBI]
synonym: "topoisomerase I inhibitor" RELATED [ChEBI]
synonym: "topoisomerase I inhibitors" RELATED [ChEBI]
synonym: "type I DNA topoisomerase inhibitor" RELATED [ChEBI]
synonym: "type I DNA topoisomerase inhibitors" RELATED [ChEBI]
is_a: CHEBI:70727 ! topoisomerase inhibitor

[Term]
id: CHEBI:50297
name: canonical nucleotide residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical nucleotide residues" RELATED [ChEBI]
is_a: CHEBI:50319 ! nucleotide residue

[Term]
id: CHEBI:50298
name: canonical deoxyribonucleotide residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical deoxyribonucleotide residues" RELATED [ChEBI]
is_a: CHEBI:50297 ! canonical nucleotide residue

[Term]
id: CHEBI:50312
name: onium compound
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:50313
name: onium cation
namespace: chebi_ontology
def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." []
subset: 3_STAR
synonym: "onium cations" EXACT IUPAC_NAME [IUPAC]
synonym: "onium cations" RELATED [ChEBI]
synonym: "onium ion" RELATED [ChEBI]
synonym: "onium ions" RELATED [ChEBI]
is_a: CHEBI:50312 ! onium compound

[Term]
id: CHEBI:50314
name: fluoronium
namespace: chebi_ontology
subset: 3_STAR
synonym: "[FH2](+)" RELATED [ChEBI]
synonym: "fluoranium" EXACT IUPAC_NAME [IUPAC]
synonym: "fluoronium" EXACT IUPAC_NAME [IUPAC]
synonym: "H2F(+)" RELATED [IUPAC]
is_a: CHEBI:50313 ! onium cation
relationship: is_conjugate_acid_of CHEBI:29228 ! hydrogen fluoride
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "FH2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/FH2/h1H2/q+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YNESUKSMQODWNS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "21.01428" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "21.01350" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][F+][H]" xsd:string

[Term]
id: CHEBI:50315
name: chloronium
namespace: chebi_ontology
subset: 3_STAR
synonym: "[ClH2](+)" RELATED [IUPAC]
synonym: "chloranium" EXACT IUPAC_NAME [IUPAC]
synonym: "chloronium" EXACT IUPAC_NAME [IUPAC]
synonym: "H2Cl(+)" RELATED [IUPAC]
xref: Gmelin:331 {source="Gmelin"}
is_a: CHEBI:50313 ! onium cation
relationship: is_conjugate_acid_of CHEBI:17883 ! hydrogen chloride
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "ClH2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH2/h1H2/q+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IGJWHVUMEJASKV-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "37.46858" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "36.98395" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][Cl+][H]" xsd:string

[Term]
id: CHEBI:50319
name: nucleotide residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "nucleotide residues" RELATED [ChEBI]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:50320
name: nucleoside residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "nucleoside residues" RELATED [ChEBI]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:50325
name: proteinogenic amino-acid side-chain group
namespace: chebi_ontology
def: "A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid." []
subset: 3_STAR
synonym: "canonical amino-acid side-chain" RELATED [ChEBI]
synonym: "canonical amino-acid side-chains" RELATED [ChEBI]
synonym: "proteinogenic amino-acid side-chain" RELATED [ChEBI]
synonym: "proteinogenic amino-acid side-chain groups" RELATED [ChEBI]
synonym: "proteinogenic amino-acid side-chains" RELATED [ChEBI]
is_a: CHEBI:33249 ! organyl group

[Term]
id: CHEBI:50326
name: sulfanylmethyl group
namespace: chebi_ontology
subset: 3_STAR
synonym: "-CH2-SH" RELATED [IUPAC]
synonym: "cysteine side-chain" RELATED [ChEBI]
synonym: "HS-CH2-" RELATED [IUPAC]
synonym: "sulfanylmethyl" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "47.10052" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "46.99555" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "SC*" xsd:string

[Term]
id: CHEBI:50329
name: 2-carboxyethyl group
namespace: chebi_ontology
subset: 3_STAR
synonym: "2-carboxyethyl" EXACT IUPAC_NAME [IUPAC]
synonym: "glutamic acid side-chain" RELATED [ChEBI]
is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H5O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "73.07060" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.02895" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(CC(=O)O)*" xsd:string

[Term]
id: CHEBI:50683
name: EC 1.5.1.3 (dihydrofolate reductase) inhibitor
namespace: chebi_ontology
def: "An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3)." []
subset: 3_STAR
synonym: "7,8-dihydrofolate reductase inhibitor" RELATED [ChEBI]
synonym: "7,8-dihydrofolate reductase inhibitors" RELATED [ChEBI]
synonym: "DHFR inhibitor" RELATED [ChEBI]
synonym: "DHFR inhibitors" RELATED [ChEBI]
synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitor" RELATED [ChEBI]
synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitors" RELATED [ChEBI]
synonym: "dihydrofolate reductase inhibitor" RELATED [ChEBI]
synonym: "dihydrofolate reductase inhibitors" RELATED [ChEBI]
synonym: "dihydrofolic acid reductase inhibitor" RELATED [ChEBI]
synonym: "dihydrofolic acid reductase inhibitors" RELATED [ChEBI]
synonym: "dihydrofolic reductase inhibitor" RELATED [ChEBI]
synonym: "dihydrofolic reductase inhibitors" RELATED [ChEBI]
synonym: "EC 1.5.1.3 (dihydrofolate reductase) inhibitors" RELATED [ChEBI]
synonym: "EC 1.5.1.3 inhibitor" RELATED [ChEBI]
synonym: "EC 1.5.1.3 inhibitors" RELATED [ChEBI]
synonym: "folic acid reductase inhibitor" RELATED [ChEBI]
synonym: "folic acid reductase inhibitors" RELATED [ChEBI]
synonym: "folic reductase inhibitor" RELATED [ChEBI]
synonym: "folic reductase inhibitors" RELATED [ChEBI]
synonym: "NADPH-dihydrofolate reductase inhibitor" RELATED [ChEBI]
synonym: "NADPH-dihydrofolate reductase inhibitors" RELATED [ChEBI]
synonym: "tetrahydrofolate dehydrogenase inhibitor" RELATED [ChEBI]
synonym: "tetrahydrofolate dehydrogenase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Dihydrofolate_reductase_inhibitor
is_a: CHEBI:73913 ! antifolate
is_a: CHEBI:76863 ! EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor

[Term]
id: CHEBI:50684
name: cross-linking reagent
namespace: chebi_ontology
def: "A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified." []
subset: 3_STAR
synonym: "cross-linking reagents" RELATED [ChEBI]
is_a: CHEBI:33893 ! reagent

[Term]
id: CHEBI:50699
name: oligosaccharide
namespace: chebi_ontology
alt_id: CHEBI:25679
alt_id: CHEBI:35319
alt_id: CHEBI:7758
def: "A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues." []
subset: 3_STAR
synonym: "O-glycosylglycoside" RELATED [ChEBI]
synonym: "O-glycosylglycosides" RELATED [ChEBI]
synonym: "oligosacarido" RELATED [ChEBI]
synonym: "oligosacaridos" RELATED [IUPAC]
synonym: "Oligosaccharide" EXACT [KEGG_COMPOUND]
synonym: "oligosaccharides" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00930
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:167559 ! glycan

[Term]
id: CHEBI:50733
name: nutraceutical
namespace: chebi_ontology
def: "A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance." []
subset: 3_STAR
synonym: "Dietary Supplement" RELATED [ChEBI]
synonym: "Food Supplementation" RELATED [ChEBI]
synonym: "Nutritional supplement" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50750
name: EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
namespace: chebi_ontology
alt_id: CHEBI:132229
alt_id: CHEBI:50234
def: "A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands." []
subset: 3_STAR
synonym: "DNA gyrase inhibitor" RELATED [ChEBI]
synonym: "DNA gyrase inhibitors" RELATED [ChEBI]
synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor" RELATED [ChEBI]
synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors" RELATED [ChEBI]
synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitor" RELATED [ChEBI]
synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitors" RELATED [ChEBI]
synonym: "DNA topoisomerase II inhibitor" RELATED [ChEBI]
synonym: "DNA topoisomerase II inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.1.3 inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.1.3 inhibitors" RELATED [ChEBI]
synonym: "inhibitor of type II topoisomerase" RELATED [ChEBI]
synonym: "inhibitors of type II topoisomerase" RELATED [ChEBI]
synonym: "topoisomerase II inhibitor" RELATED [ChEBI]
synonym: "topoisomerase II inhibitors" RELATED [ChEBI]
synonym: "topoisomerase-II inhibitor" RELATED [ChEBI]
synonym: "topoisomerase-II inhibitors" RELATED [ChEBI]
synonym: "type II DNA topoisomerase inhibitor" RELATED [ChEBI]
synonym: "type II DNA topoisomerase inhibitors" RELATED [ChEBI]
is_a: CHEBI:70727 ! topoisomerase inhibitor

[Term]
id: CHEBI:50846
name: immunomodulator
namespace: chebi_ontology
def: "Biologically active substance whose activity affects or plays a role in the functioning of the immune system." []
subset: 3_STAR
synonym: "Biomodulator" RELATED [ChEBI]
synonym: "Immune factor" RELATED [ChEBI]
synonym: "Immunologic factor" RELATED [ChEBI]
synonym: "Immunological factor" RELATED [ChEBI]
synonym: "immunomodulators" RELATED [ChEBI]
xref: Wikipedia:Immunotherapy
is_a: CHEBI:23888 ! drug
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:50860
name: organic molecular entity
namespace: chebi_ontology
alt_id: CHEBI:25700
alt_id: CHEBI:33244
def: "Any molecular entity that contains carbon." []
subset: 3_STAR
synonym: "organic compounds" RELATED [ChEBI]
synonym: "organic entity" RELATED [ChEBI]
synonym: "organic molecular entities" RELATED [ChEBI]
is_a: CHEBI:33582 ! carbon group molecular entity
relationship: BFO:0000051 CHEBI:27594 ! has part carbon atom

[Term]
id: CHEBI:50893
name: azaarene
namespace: chebi_ontology
subset: 3_STAR
synonym: "azaarenes" RELATED [ChEBI]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:50902
name: genotoxin
namespace: chebi_ontology
def: "A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells." []
subset: 3_STAR
synonym: "genotoxic agent" RELATED [ChEBI]
synonym: "genotoxic agents" RELATED [ChEBI]
synonym: "genotoxins" RELATED [ChEBI]
xref: Wikipedia:Genotoxicity
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50903
name: carcinogenic agent
namespace: chebi_ontology
def: "A role played by a chemical compound which is known to  induce a process of carcinogenesis  by corrupting  normal cellular pathways, leading to the acquistion of tumoral capabilities." []
subset: 3_STAR
synonym: "agente carcinogeno" RELATED [ChEBI]
synonym: "cancerigene" RELATED [ChEBI]
synonym: "cancerogene" RELATED [ChEBI]
synonym: "carcinogen" RELATED [ChEBI]
synonym: "carcinogene" RELATED [ChEBI]
synonym: "carcinogenic agents" RELATED [ChEBI]
synonym: "carcinogeno" RELATED [ChEBI]
synonym: "carcinogens" RELATED [ChEBI]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50904
name: allergen
namespace: chebi_ontology
def: "A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy." []
subset: 3_STAR
synonym: "alergeno" RELATED [ChEBI]
synonym: "allergene" RELATED [ChEBI]
synonym: "allergenic agent" RELATED [ChEBI]
xref: Wikipedia:Allergen
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50905
name: teratogenic agent
namespace: chebi_ontology
def: "A role played by a chemical compound  in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect." []
subset: 3_STAR
synonym: "agent teratogene" RELATED [ChEBI]
synonym: "teratogen" RELATED [ChEBI]
synonym: "teratogeno" RELATED [ChEBI]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50906
name: role
namespace: chebi_ontology
def: "A role is particular behaviour which a material entity may exhibit." []
subset: 3_STAR

[Term]
id: CHEBI:50908
name: hepatotoxic agent
namespace: chebi_ontology
def: "A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals." []
subset: 3_STAR
synonym: "agente hepatotoxico" RELATED [ChEBI]
synonym: "hepatotoxic agents" RELATED [ChEBI]
synonym: "hepatotoxicant" RELATED [ChEBI]
synonym: "hepatotoxicants" RELATED [ChEBI]
synonym: "hepatotoxin" RELATED [ChEBI]
synonym: "hepatotoxins" RELATED [ChEBI]
synonym: "hepatoxic agent" RELATED [ChEBI]
synonym: "hepatoxicant" RELATED [ChEBI]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50909
name: nephrotoxic agent
namespace: chebi_ontology
def: "A role played by a chemical compound exihibiting itself through the ability to induce damage to the kidney in animals." []
subset: 3_STAR
synonym: "agente nefrotoxico" RELATED [ChEBI]
synonym: "nephrotoxicant" RELATED [ChEBI]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50910
name: neurotoxin
namespace: chebi_ontology
alt_id: CHEBI:50911
def: "A poison that interferes with the functions of the nervous system." []
subset: 3_STAR
synonym: "agente neurotoxico" RELATED [ChEBI]
synonym: "nerve poison" RELATED [ChEBI]
synonym: "nerve poisons" RELATED [ChEBI]
synonym: "neurotoxic agent" RELATED [ChEBI]
synonym: "neurotoxic agents" RELATED [ChEBI]
synonym: "neurotoxicant" RELATED [ChEBI]
synonym: "neurotoxins" RELATED [ChEBI]
xref: Wikipedia:Neurotoxin
is_a: CHEBI:52209 ! aetiopathogenetic role
is_a: CHEBI:64909 ! poison

[Term]
id: CHEBI:50925
name: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:75764
def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine." []
subset: 3_STAR
synonym: "A-kinase inhibitor" RELATED [ChEBI]
synonym: "A-kinase inhibitors" RELATED [ChEBI]
synonym: "AP50 kinase inhibitor" RELATED [ChEBI]
synonym: "AP50 kinase inhibitors" RELATED [ChEBI]
synonym: "ATP-protein transphosphorylase inhibitor" RELATED [ChEBI]
synonym: "ATP-protein transphosphorylase inhibitors" RELATED [ChEBI]
synonym: "ATP:protein phosphotransferase (non-specific) inhibitor" RELATED [ChEBI]
synonym: "ATP:protein phosphotransferase (non-specific) inhibitors" RELATED [ChEBI]
synonym: "betaIIPKC inhibitor" RELATED [ChEBI]
synonym: "betaIIPKC inhibitors" RELATED [ChEBI]
synonym: "BR serine/threonine-protein kinase 2 inhibitor" RELATED [ChEBI]
synonym: "BR serine/threonine-protein kinase 2 inhibitors" RELATED [ChEBI]
synonym: "calcium-dependent protein kinase C inhibitor" RELATED [ChEBI]
synonym: "calcium-dependent protein kinase C inhibitors" RELATED [ChEBI]
synonym: "calcium/phospholipid-dependent protein kinase inhibitor" RELATED [ChEBI]
synonym: "calcium/phospholipid-dependent protein kinase inhibitors" RELATED [ChEBI]
synonym: "cAMP-dependent protein kinase A inhibitor" RELATED [ChEBI]
synonym: "cAMP-dependent protein kinase A inhibitors" RELATED [ChEBI]
synonym: "cAMP-dependent protein kinase inhibitor" RELATED [ChEBI]
synonym: "cAMP-dependent protein kinase inhibitors" RELATED [ChEBI]
synonym: "casein kinase (phosphorylating) inhibitor" RELATED [ChEBI]
synonym: "casein kinase (phosphorylating) inhibitors" RELATED [ChEBI]
synonym: "casein kinase 2 inhibitor" RELATED [ChEBI]
synonym: "casein kinase 2 inhibitors" RELATED [ChEBI]
synonym: "casein kinase I inhibitor" RELATED [ChEBI]
synonym: "casein kinase I inhibitors" RELATED [ChEBI]
synonym: "casein kinase II inhibitor" RELATED [ChEBI]
synonym: "casein kinase II inhibitors" RELATED [ChEBI]
synonym: "casein kinase inhibitor" RELATED [ChEBI]
synonym: "casein kinase inhibitors" RELATED [ChEBI]
synonym: "cGMP-dependent protein kinase inhibitor" RELATED [ChEBI]
synonym: "cGMP-dependent protein kinase inhibitors" RELATED [ChEBI]
synonym: "CK-2 inhibitor" RELATED [ChEBI]
synonym: "CK-2 inhibitors" RELATED [ChEBI]
synonym: "CKI inhibitor" RELATED [ChEBI]
synonym: "CKI inhibitors" RELATED [ChEBI]
synonym: "CKII inhibitor" RELATED [ChEBI]
synonym: "CKII inhibitors" RELATED [ChEBI]
synonym: "cyclic AMP-dependent protein kinase A inhibitor" RELATED [ChEBI]
synonym: "cyclic AMP-dependent protein kinase A inhibitors" RELATED [ChEBI]
synonym: "cyclic AMP-dependent protein kinase inhibitor" RELATED [ChEBI]
synonym: "cyclic AMP-dependent protein kinase inhibitors" RELATED [ChEBI]
synonym: "cyclic monophosphate-dependent protein kinase inhibitor" RELATED [ChEBI]
synonym: "cyclic monophosphate-dependent protein kinase inhibitors" RELATED [ChEBI]
synonym: "cyclic nucleotide-dependent protein kinase inhibitor" RELATED [ChEBI]
synonym: "cyclic nucleotide-dependent protein kinase inhibitors" RELATED [ChEBI]
synonym: "cyclin-dependent kinase inhibitor" RELATED [ChEBI]
synonym: "cyclin-dependent kinase inhibitors" RELATED [ChEBI]
synonym: "dsk1 inhibitor" RELATED [ChEBI]
synonym: "dsk1 inhibitors" RELATED [ChEBI]
synonym: "EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors" RELATED [ChEBI]
synonym: "EC 2.7.11.1 inhibitor" RELATED [ChEBI]
synonym: "EC 2.7.11.1 inhibitors" RELATED [ChEBI]
synonym: "epsilon PKC inhibitor" RELATED [ChEBI]
synonym: "epsilon PKC inhibitors" RELATED [ChEBI]
synonym: "glycogen synthase a kinase inhibitor" RELATED [ChEBI]
synonym: "glycogen synthase a kinase inhibitors" RELATED [ChEBI]
synonym: "glycogen synthase kinase inhibitor" RELATED [ChEBI]
synonym: "glycogen synthase kinase inhibitors" RELATED [ChEBI]
synonym: "HIPK2 inhibitor" RELATED [ChEBI]
synonym: "HIPK2 inhibitors" RELATED [ChEBI]
synonym: "Hpr kinase inhibitor" RELATED [ChEBI]
synonym: "Hpr kinase inhibitors" RELATED [ChEBI]
synonym: "hydroxyalkyl-protein kinase inhibitor" RELATED [ChEBI]
synonym: "hydroxyalkyl-protein kinase inhibitors" RELATED [ChEBI]
synonym: "M phase-specific cdc2 kinase inhibitor" RELATED [ChEBI]
synonym: "M phase-specific cdc2 kinase inhibitors" RELATED [ChEBI]
synonym: "mitogen-activated S6 kinase inhibitor" RELATED [ChEBI]
synonym: "mitogen-activated S6 kinase inhibitors" RELATED [ChEBI]
synonym: "MKNK2 inhibitor" RELATED [ChEBI]
synonym: "MKNK2 inhibitors" RELATED [ChEBI]
synonym: "non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitor" RELATED [ChEBI]
synonym: "non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors" RELATED [ChEBI]
synonym: "non-specific serine/threonine protein kinase inhibitor" RELATED [ChEBI]
synonym: "non-specific serine/threonine protein kinase inhibitors" RELATED [ChEBI]
synonym: "p21 activated kinase-1 inhibitor" RELATED [ChEBI]
synonym: "p21 activated kinase-1 inhibitors" RELATED [ChEBI]
synonym: "p82 kinase inhibitor" RELATED [ChEBI]
synonym: "p82 kinase inhibitors" RELATED [ChEBI]
synonym: "PAK-1 inhibitor" RELATED [ChEBI]
synonym: "PAK-1 inhibitors" RELATED [ChEBI]
synonym: "PAK1 inhibitor" RELATED [ChEBI]
synonym: "PAK1 inhibitors" RELATED [ChEBI]
synonym: "phosphorylase b kinase kinase inhibitor" RELATED [ChEBI]
synonym: "phosphorylase b kinase kinase inhibitors" RELATED [ChEBI]
synonym: "PKA inhibitor" RELATED [ChEBI]
synonym: "PKA inhibitors" RELATED [ChEBI]
synonym: "protein glutamyl kinase inhibitor" RELATED [ChEBI]
synonym: "protein glutamyl kinase inhibitors" RELATED [ChEBI]
synonym: "protein kinase (phosphorylating) inhibitor" RELATED [ChEBI]
synonym: "protein kinase (phosphorylating) inhibitors" RELATED [ChEBI]
synonym: "protein kinase A inhibitor" RELATED [ChEBI]
synonym: "protein kinase A inhibitors" RELATED [ChEBI]
synonym: "protein kinase CK2 inhibitor" RELATED [ChEBI]
synonym: "protein kinase CK2 inhibitors" RELATED [ChEBI]
synonym: "protein kinase p58 inhibitor" RELATED [ChEBI]
synonym: "protein kinase p58 inhibitors" RELATED [ChEBI]
synonym: "protein phosphokinase inhibitor" RELATED [ChEBI]
synonym: "protein phosphokinase inhibitors" RELATED [ChEBI]
synonym: "protein serine kinase inhibitor" RELATED [ChEBI]
synonym: "protein serine kinase inhibitors" RELATED [ChEBI]
synonym: "protein serine-threonine kinase inhibitor" RELATED [ChEBI]
synonym: "protein serine-threonine kinase inhibitors" RELATED [ChEBI]
synonym: "protein-aspartyl kinase inhibitor" RELATED [ChEBI]
synonym: "protein-aspartyl kinase inhibitors" RELATED [ChEBI]
synonym: "protein-cysteine kinase inhibitor" RELATED [ChEBI]
synonym: "protein-cysteine kinase inhibitors" RELATED [ChEBI]
synonym: "protein-serine kinase inhibitor" RELATED [ChEBI]
synonym: "protein-serine kinase inhibitors" RELATED [ChEBI]
synonym: "protein-serine/threonine kinase inhibitors" RELATED [ChEBI]
synonym: "Prp4 protein kinase inhibitor" RELATED [ChEBI]
synonym: "Prp4 protein kinase inhibitors" RELATED [ChEBI]
synonym: "Raf kinase inhibitor" RELATED [ChEBI]
synonym: "Raf kinase inhibitors" RELATED [ChEBI]
synonym: "Raf-1 inhibitor" RELATED [ChEBI]
synonym: "Raf-1 inhibitors" RELATED [ChEBI]
synonym: "ribosomal protein S6 kinase II inhibitor" RELATED [ChEBI]
synonym: "ribosomal protein S6 kinase II inhibitors" RELATED [ChEBI]
synonym: "ribosomal S6 protein kinase inhibitor" RELATED [ChEBI]
synonym: "ribosomal S6 protein kinase inhibitors" RELATED [ChEBI]
synonym: "serine kinase inhibitor" RELATED [ChEBI]
synonym: "serine kinase inhibitors" RELATED [ChEBI]
synonym: "serine protein kinase inhibitor" RELATED [ChEBI]
synonym: "serine protein kinase inhibitors" RELATED [ChEBI]
synonym: "serine(threonine) protein kinase inhibitor" RELATED [ChEBI]
synonym: "serine(threonine) protein kinase inhibitors" RELATED [ChEBI]
synonym: "serine-specific protein kinase inhibitor" RELATED [ChEBI]
synonym: "serine-specific protein kinase inhibitors" RELATED [ChEBI]
synonym: "serine/threonine protein kinase inhibitor" RELATED [ChEBI]
synonym: "serine/threonine protein kinase inhibitors" RELATED [ChEBI]
synonym: "STK32 inhibitor" RELATED [ChEBI]
synonym: "STK32 inhibitors" RELATED [ChEBI]
synonym: "T-antigen kinase inhibitor" RELATED [ChEBI]
synonym: "T-antigen kinase inhibitors" RELATED [ChEBI]
synonym: "threonine-specific protein kinase inhibitor" RELATED [ChEBI]
synonym: "threonine-specific protein kinase inhibitors" RELATED [ChEBI]
synonym: "twitchin kinase inhibitor" RELATED [ChEBI]
synonym: "twitchin kinase inhibitors" RELATED [ChEBI]
synonym: "type-2 casein kinase inhibitor" RELATED [ChEBI]
synonym: "type-2 casein kinase inhibitors" RELATED [ChEBI]
synonym: "Wee 1-like kinase inhibitor" RELATED [ChEBI]
synonym: "Wee 1-like kinase inhibitors" RELATED [ChEBI]
synonym: "Wee-kinase inhibitor" RELATED [ChEBI]
synonym: "Wee-kinase inhibitors" RELATED [ChEBI]
synonym: "WEE1Hu inhibitor" RELATED [ChEBI]
synonym: "WEE1Hu inhibitors" RELATED [ChEBI]
is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor

[Term]
id: CHEBI:50929
name: aziridinium
namespace: chebi_ontology
subset: 3_STAR
synonym: "aziridinium" EXACT IUPAC_NAME [IUPAC]
synonym: "aziridinium ion" RELATED [ChEBI]
xref: Gmelin:322803 {source="Gmelin"}
is_a: CHEBI:37949 ! azacycloalkane
is_a: CHEBI:50946 ! aziridinium ion
relationship: is_conjugate_acid_of CHEBI:30969 ! aziridine
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H6N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H5N/c1-2-3-1/h3H,1-2H2/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NOWKCMXCCJGMRR-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.07578" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.04948" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1C[NH2+]1" xsd:string

[Term]
id: CHEBI:50930
name: thioxanthenes
namespace: chebi_ontology
def: "Thioxanthene and its substitution derivatives." []
subset: 3_STAR
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38106 ! organosulfur heterocyclic compound

[Term]
id: CHEBI:50946
name: aziridinium ion
namespace: chebi_ontology
def: "Compounds containing an aziridine ring that contains a quaternary nitrogen atom." []
subset: 3_STAR
synonym: "aziridinium ions" RELATED [ChEBI]
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:50996
name: tertiary amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups." []
subset: 3_STAR
synonym: "tertiary amino compounds" RELATED [ChEBI]
is_a: CHEBI:50047 ! organic amino compound
relationship: is_conjugate_base_of CHEBI:137982 ! tertiary ammonium ion

[Term]
id: CHEBI:51052
name: lucanthone
namespace: chebi_ontology
alt_id: CHEBI:19039
alt_id: CHEBI:6552
def: "A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone." []
subset: 3_STAR
synonym: "1-((2-(diethylamino)ethyl)amino)-4-methylthioxanthen-9-one" RELATED [ChemIDplus]
synonym: "1-diethylaminoethylethylamino-4-methyl-thioxanthenone" RELATED [ChEBI]
synonym: "1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one" EXACT IUPAC_NAME [IUPAC]
synonym: "1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one" RELATED [ChEBI]
synonym: "Lucanthone" EXACT [KEGG_COMPOUND]
synonym: "lucanthone" RELATED INN [WHO_MedNet]
synonym: "lucanthone" RELATED INN [ChemIDplus]
synonym: "lucanthonum" RELATED INN [ChemIDplus]
synonym: "lucantona" RELATED INN [ChemIDplus]
xref: Beilstein:312369 {source="Beilstein"}
xref: CAS:479-50-5 {source="ChemIDplus"}
xref: CAS:479-50-5 {source="KEGG COMPOUND"}
xref: Drug_Central:1616 {source="DrugCentral"}
xref: DrugBank:DB04967
xref: HMDB:HMDB0015607
xref: KEGG:C11715
xref: PMID:21148553 {source="Europe PMC"}
xref: PMID:21935361 {source="Europe PMC"}
xref: PMID:4368942 {source="Europe PMC"}
xref: PMID:6887199 {source="Europe PMC"}
xref: PMID:9169823 {source="Europe PMC"}
xref: Reaxys:312369 {source="Reaxys"}
xref: Wikipedia:Lucanthone
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:50930 ! thioxanthenes
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:38941 ! has role schistosomicide drug
relationship: RO:0000087 CHEBI:47868 ! has role photosensitizing agent
relationship: RO:0000087 CHEBI:50266 ! has role prodrug
relationship: RO:0000087 CHEBI:50276 ! has role EC 5.99.1.2 (DNA topoisomerase) inhibitor
relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
relationship: RO:0000087 CHEBI:60809 ! has role adjuvant
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H24N2OS" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H24N2OS/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20/h6-11,21H,4-5,12-13H2,1-3H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FBQPGGIHOFZRGH-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "340.48200" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "340.16093" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12" xsd:string

[Term]
id: CHEBI:51061
name: hormone receptor modulator
namespace: chebi_ontology
def: "A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." []
subset: 3_STAR
synonym: "hormone receptor modulators" RELATED [ChEBI]
is_a: CHEBI:90710 ! receptor modulator

[Term]
id: CHEBI:51067
name: tetraphenes
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound

[Term]
id: CHEBI:51069
name: organic halide salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic halide salts" RELATED [ChEBI]
is_a: CHEBI:24868 ! organic salt

[Term]
id: CHEBI:51070
name: Janus Green B cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "3-(diethylamino)-7-{(E)-[4-(dimethylamino)phenyl]diazenyl}-5-phenylphenazin-5-ium" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:9234599 {source="Beilstein"}
is_a: CHEBI:39201 ! phenazines
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C30H31N6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C30H31N6/c1-5-35(6-2)26-17-19-28-30(21-26)36(25-10-8-7-9-11-25)29-20-23(14-18-27(29)31-28)33-32-22-12-15-24(16-13-22)34(3)4/h7-21H,5-6H2,1-4H3/q+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TYOFQDFFFPHHNT-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "475.60758" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "475.26047" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CC)c1ccc2nc3ccc(cc3[n+](-c3ccccc3)c2c1)\\N=N\\c1ccc(cc1)N(C)C" xsd:string

[Term]
id: CHEBI:51086
name: chemical role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof within a chemical context." []
subset: 3_STAR
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:51143
name: nitrogen molecular entity
namespace: chebi_ontology
alt_id: CHEBI:25556
alt_id: CHEBI:7594
subset: 3_STAR
synonym: "nitrogen compounds" RELATED [ChEBI]
synonym: "nitrogen molecular entities" RELATED [ChEBI]
synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND]
xref: KEGG:C06061
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: BFO:0000051 CHEBI:25555 ! has part nitrogen atom

[Term]
id: CHEBI:51144
name: nitrogen group
namespace: chebi_ontology
subset: 3_STAR
synonym: "nitrogen group" EXACT [ChEBI]
synonym: "nitrogen groups" RELATED [ChEBI]
synonym: "nitrogen-containing group" RELATED [ChEBI]
synonym: "nitrogenous group" RELATED [ChEBI]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:51151
name: dipolar compound
namespace: chebi_ontology
def: "An  organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." []
subset: 3_STAR
synonym: "dipolar compounds" RELATED [ChEBI]
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:51214
name: diamminedichloroplatinum
namespace: chebi_ontology
subset: 3_STAR
synonym: "diammine(dichloro)platinum" RELATED [ChEBI]
synonym: "diamminedichloridoplatinum" EXACT IUPAC_NAME [IUPAC]
synonym: "diamminedichloridoplatinum(II)" EXACT IUPAC_NAME [IUPAC]
synonym: "diamminedichloroplatinum" EXACT IUPAC_NAME [IUPAC]
synonym: "diamminedichloroplatinum(II)" EXACT IUPAC_NAME [IUPAC]
synonym: "diammineplatinum dichloride" RELATED [NIST_Chemistry_WebBook]
xref: CAS:14913-33-8 {source="NIST Chemistry WebBook"}
xref: Gmelin:101110 {source="Gmelin"}
is_a: CHEBI:33862 ! platinum coordination entity
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl2H6N2Pt" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "300.045" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "298.95559" xsd:string

[Term]
id: CHEBI:51336
name: metal sulfate
namespace: chebi_ontology
def: "Sulfate salts where the cation is a metal ion." []
subset: 3_STAR
synonym: "metal sulfates" RELATED [ChEBI]
is_a: CHEBI:24840 ! inorganic sulfate salt

[Term]
id: CHEBI:51348
name: tetraphene
namespace: chebi_ontology
alt_id: CHEBI:33088
alt_id: CHEBI:34557
def: "An angular ortho-fused polycyclic arene consisting of four fused benzene rings." []
subset: 3_STAR
synonym: "1,2-Benzanthracene" RELATED [KEGG_COMPOUND]
synonym: "1,2-Benzanthrazen" RELATED [ChemIDplus]
synonym: "2,3-benzphenanthrene" RELATED [ChemIDplus]
synonym: "Benz[a]anthracene" RELATED [KEGG_COMPOUND]
synonym: "benzanthrene" RELATED [NIST_Chemistry_WebBook]
synonym: "naphthanthracene" RELATED [ChemIDplus]
synonym: "tetraphene" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:1909298 {source="Beilstein"}
xref: CAS:56-55-3 {source="ChemIDplus"}
xref: CAS:56-55-3 {source="NIST Chemistry WebBook"}
xref: CAS:56-55-3 {source="KEGG COMPOUND"}
xref: Gmelin:244702 {source="Gmelin"}
xref: KEGG:C14317
xref: Patent:DE481819
xref: Patent:DE486766
xref: PMID:25528193 {source="Europe PMC"}
xref: PMID:25528488 {source="Europe PMC"}
xref: PMID:26720419 {source="Europe PMC"}
xref: PMID:7561049 {source="Europe PMC"}
xref: Reaxys:1909298 {source="Reaxys"}
xref: Wikipedia:Tetraphene
is_a: CHEBI:35296 ! ortho-fused polycyclic arene
is_a: CHEBI:51067 ! tetraphenes
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H12" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H12/c1-2-7-15-12-18-16(11-14(15)6-1)10-9-13-5-3-4-8-17(13)18/h1-12H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DXBHBZVCASKNBY-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "228.28788" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "228.09390" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2cc3c(ccc4ccccc34)cc2c1" xsd:string

[Term]
id: CHEBI:51422
name: organodiyl group
namespace: chebi_ontology
def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." []
subset: 3_STAR
synonym: "organodiyl groups" RELATED [ChEBI]
is_a: CHEBI:51446 ! organic divalent group

[Term]
id: CHEBI:51446
name: organic divalent group
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51447
name: organic univalent group
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51569
name: N-acyl-amino acid
namespace: chebi_ontology
alt_id: CHEBI:21653
alt_id: CHEBI:22226
def: "A carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid." []
subset: 3_STAR
synonym: "acyl-amino-acid" RELATED [ChEBI]
synonym: "acyl-amino-acids" RELATED [ChEBI]
synonym: "acylamino acids" RELATED [ChEBI]
synonym: "N-acyl amino acid" RELATED [ChEBI]
synonym: "N-acyl amino acids" RELATED [ChEBI]
synonym: "N-acyl-amino-acid" RELATED [ChEBI]
synonym: "N-acyl-amino-acids" RELATED [ChEBI]
synonym: "N-acylamino acid" RELATED [ChEBI]
synonym: "N-acylamino acids" RELATED [ChEBI]
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:83821 ! amino acid derivative
relationship: has_functional_parent CHEBI:33709 ! amino acid

[Term]
id: CHEBI:51803
name: aminoacridines
namespace: chebi_ontology
def: "Acridines which are substituted in any position by one or more amino groups or substituted amino groups. Note that the term 'aminoacridine' is the International Prorietary Name (INN) for 9-aminoacridine." []
subset: 3_STAR
synonym: "aminoacridine" RELATED [ChEBI]
is_a: CHEBI:22213 ! acridines

[Term]
id: CHEBI:51958
name: organic polycyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic polycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:51959
name: organic tricyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic tricyclic compounds" RELATED [ChEBI]
is_a: CHEBI:51958 ! organic polycyclic compound

[Term]
id: CHEBI:52206
name: biochemical role
namespace: chebi_ontology
def: "A biological role played by the molecular entity or part thereof within a biochemical context." []
subset: 3_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52208
name: biophysical role
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52209
name: aetiopathogenetic role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." []
subset: 3_STAR
synonym: "etiopathogenetic agent" RELATED [ChEBI]
synonym: "etiopathogenetic role" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52210
name: pharmacological role
namespace: chebi_ontology
def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." []
subset: 3_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52211
name: physiological role
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52217
name: pharmaceutical
namespace: chebi_ontology
alt_id: CHEBI:33293
alt_id: CHEBI:33294
def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." []
subset: 3_STAR
synonym: "farmaco" RELATED [ChEBI]
synonym: "medicament" RELATED [ChEBI]
synonym: "pharmaceuticals" RELATED [ChEBI]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:52684
name: butanediol
namespace: chebi_ontology
def: "A member of the class of butanediols that is butane in which two of the hydrogens have been replaced by hydroxy groups." []
subset: 3_STAR
synonym: "butanediol" EXACT IUPAC_NAME [IUPAC]
synonym: "butanediols" RELATED [ChEBI]
is_a: CHEBI:22944 ! butanediols
relationship: has_parent_hydride CHEBI:37808 ! butane

[Term]
id: CHEBI:52768
name: hycanthone
namespace: chebi_ontology
def: "A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel." []
subset: 3_STAR
synonym: "1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one" RELATED [ChemIDplus]
synonym: "1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one" RELATED [ChemIDplus]
synonym: "1-(2-diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one" RELATED [ChEBI]
synonym: "1-{[2-(diethylamino)ethyl]amino}-4-(hydroxymethyl)-9H-thioxanthen-9-one" EXACT IUPAC_NAME [IUPAC]
synonym: "hicantona" RELATED INN [ChemIDplus]
synonym: "Hycanthon" RELATED [ChemIDplus]
synonym: "Hycanthone" EXACT [KEGG_DRUG]
synonym: "hycanthone" RELATED INN [WHO_MedNet]
synonym: "hycanthone" RELATED INN [KEGG_DRUG]
synonym: "hycanthonum" RELATED INN [ChemIDplus]
synonym: "Lucanthone metabolite" RELATED [ChemIDplus]
xref: Beilstein:1402722 {source="Beilstein"}
xref: CAS:3105-97-3 {source="KEGG DRUG"}
xref: CAS:3105-97-3 {source="ChemIDplus"}
xref: Drug_Central:1383 {source="DrugCentral"}
xref: KEGG:D00541
xref: LINCS:LSM-5614
xref: Patent:NL6410359
xref: Patent:US3294803
xref: Patent:US3312598
xref: PMID:1888160 {source="Europe PMC"}
xref: PMID:21935361 {source="Europe PMC"}
xref: PMID:2957147 {source="Europe PMC"}
xref: PMID:5573958 {source="Europe PMC"}
xref: PMID:626982 {source="Europe PMC"}
xref: PMID:7369442 {source="Europe PMC"}
xref: Reaxys:1402722 {source="Reaxys"}
xref: Wikipedia:Hycanthone
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:50930 ! thioxanthenes
relationship: has_functional_parent CHEBI:51052 ! lucanthone
relationship: is_conjugate_base_of CHEBI:67141 ! hycanthone(1+)
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:38941 ! has role schistosomicide drug
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H24N2O2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MFZWMTSUNYWVBU-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "356.48200" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "356.15585" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12" xsd:string

[Term]
id: CHEBI:53121
name: adenosine A2A receptor antagonist
namespace: chebi_ontology
def: "An antagonist at the A2A receptor." []
subset: 3_STAR
synonym: "adenosine A2A receptor antagonists" RELATED [ChEBI]
xref: Wikipedia:Adenosine_A2A_receptor
is_a: CHEBI:71232 ! adenosine receptor antagonist

[Term]
id: CHEBI:53526
name: tritiated thymidine
namespace: chebi_ontology
def: "Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis." []
subset: 3_STAR
synonym: "(3)HTdR" RELATED [ChEBI]
synonym: "(3H)Thymidine" RELATED [ChemIDplus]
synonym: "Thymidine-(H-3)" RELATED [ChemIDplus]
synonym: "tritiated thymidines" RELATED [ChEBI]
xref: CAS:50-88-4 {source="ChemIDplus"}
is_a: CHEBI:139359 ! tritiated compound
is_a: CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside
relationship: has_functional_parent CHEBI:17748 ! thymidine

[Term]
id: CHEBI:5686
name: heterocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of at least two different elements." []
subset: 3_STAR
synonym: "compuesto heterociclico" RELATED [IUPAC]
synonym: "compuestos heterociclicos" RELATED [IUPAC]
synonym: "heterocycle" RELATED [ChEBI]
synonym: "Heterocyclic compound" EXACT [KEGG_COMPOUND]
synonym: "heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:57981
name: D-phenylalanine zwitterion
namespace: chebi_ontology
def: "A D-alpha-amino acid zwitterion that is D-phenylalanine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." []
subset: 3_STAR
synonym: "(2R)-2-ammonio-3-phenylpropanoate" RELATED [IUPAC]
synonym: "(2R)-2-azaniumyl-3-phenylpropanoate" EXACT IUPAC_NAME [IUPAC]
synonym: "D-phenylalanine" RELATED [UniProt]
xref: MetaCyc:CPD-216
is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion
relationship: is_enantiomer_of CHEBI:58095 ! L-phenylalanine zwitterion
relationship: is_tautomer_of CHEBI:16998 ! D-phenylalanine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18910" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H](Cc1ccccc1)C([O-])=O" xsd:string

[Term]
id: CHEBI:58095
name: L-phenylalanine zwitterion
namespace: chebi_ontology
def: "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of L-phenylalanine; major species at pH 7.3." []
subset: 3_STAR
synonym: "(2S)-2-ammonio-3-phenylpropanoate" RELATED [IUPAC]
synonym: "(2S)-2-azaniumyl-3-phenylpropanoate" EXACT IUPAC_NAME [IUPAC]
synonym: "L-phenylalanine" RELATED [UniProt]
synonym: "phenylalanine" RELATED [ChEBI]
xref: MetaCyc:PHE
xref: PMID:21956539 {source="Europe PMC"}
is_a: CHEBI:35238 ! amino acid zwitterion
relationship: is_enantiomer_of CHEBI:57981 ! D-phenylalanine zwitterion
relationship: is_tautomer_of CHEBI:17295 ! L-phenylalanine
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18910" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H](Cc1ccccc1)C([O-])=O" xsd:string

[Term]
id: CHEBI:58951
name: short-chain fatty acid anion
namespace: chebi_ontology
def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)." []
subset: 3_STAR
synonym: "a short-chain fatty acid" RELATED [UniProt]
synonym: "short-chain fatty acid anions" RELATED [ChEBI]
is_a: CHEBI:28868 ! fatty acid anion
relationship: is_conjugate_base_of CHEBI:26666 ! short-chain fatty acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string

[Term]
id: CHEBI:58953
name: saturated fatty acid anion
namespace: chebi_ontology
def: "Any fatty acid anion in which there is no C-C unsaturation." []
subset: 3_STAR
synonym: "saturated fatty acid anions" RELATED [ChEBI]
is_a: CHEBI:28868 ! fatty acid anion

[Term]
id: CHEBI:58954
name: straight-chain saturated fatty acid anion
namespace: chebi_ontology
def: "Any saturated fatty acid anion lacking a carbon side-chain." []
subset: 3_STAR
synonym: "straight-chain saturated fatty acid anions" RELATED [ChEBI]
is_a: CHEBI:58953 ! saturated fatty acid anion
relationship: is_conjugate_base_of CHEBI:39418 ! straight-chain saturated fatty acid

[Term]
id: CHEBI:58958
name: organosulfate oxoanion
namespace: chebi_ontology
def: "An organic anion of general formula RS(=O)2O(-) where R is an organyl group." []
subset: 3_STAR
synonym: "organosulfate oxoanions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: has_functional_parent CHEBI:16189 ! sulfate
relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06300" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S(=O)(=O)O[*]" xsd:string

[Term]
id: CHEBI:59202
name: straight-chain fatty acid
namespace: chebi_ontology
def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." []
subset: 3_STAR
synonym: "straight-chain fatty acids" RELATED [ChEBI]
is_a: CHEBI:35366 ! fatty acid
relationship: is_conjugate_acid_of CHEBI:59203 ! straight-chain fatty acid anion

[Term]
id: CHEBI:59203
name: straight-chain fatty acid anion
namespace: chebi_ontology
def: "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." []
subset: 3_STAR
synonym: "straight-chain FA anion" RELATED [ChEBI]
synonym: "straight-chain FA anions" RELATED [ChEBI]
synonym: "straight-chain fatty acid anions" RELATED [ChEBI]
is_a: CHEBI:28868 ! fatty acid anion
relationship: is_conjugate_base_of CHEBI:59202 ! straight-chain fatty acid

[Term]
id: CHEBI:59698
name: phosphoric acids
namespace: chebi_ontology
def: "Compounds containing one or more phosphoric acid units." []
subset: 3_STAR
is_a: CHEBI:33457 ! phosphorus oxoacid

[Term]
id: CHEBI:59740
name: nucleophilic reagent
namespace: chebi_ontology
def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." []
subset: 3_STAR
synonym: "nucleophile" RELATED [ChEBI]
synonym: "nucleophiles" RELATED [ChEBI]
synonym: "nucleophilic reagents" RELATED [ChEBI]
is_a: CHEBI:33893 ! reagent
is_a: CHEBI:39144 ! Lewis base

[Term]
id: CHEBI:59765
name: boric acids
namespace: chebi_ontology
def: "Hydroxy boron compounds of general formula BxOyHz." []
subset: 3_STAR
is_a: CHEBI:33145 ! boron oxoacid
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid

[Term]
id: CHEBI:59814
name: L-alpha-amino acid anion
namespace: chebi_ontology
def: "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." []
subset: 3_STAR
synonym: "L-alpha-amino carboxylate" RELATED [ChEBI]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: is_conjugate_base_of CHEBI:15705 ! L-alpha-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "73.051" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.01638" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H](C(=O)[O-])(N)*" xsd:string

[Term]
id: CHEBI:59869
name: L-alpha-amino acid zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group." []
subset: 3_STAR
synonym: "an L-alpha-amino acid" RELATED [UniProt]
synonym: "L-alpha-amino acid zwitterions" RELATED [ChEBI]
is_a: CHEBI:78608 ! alpha-amino acid zwitterion
relationship: is_tautomer_of CHEBI:15705 ! L-alpha-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H]([*])C([O-])=O" xsd:string

[Term]
id: CHEBI:59871
name: D-alpha-amino acid zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group." []
subset: 3_STAR
synonym: "a D-alpha-amino acid" RELATED [UniProt]
synonym: "D-alpha-amino acid zwitterions" RELATED [ChEBI]
is_a: CHEBI:35238 ! amino acid zwitterion
relationship: is_tautomer_of CHEBI:16733 ! D-alpha-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H]([*])C([O-])=O" xsd:string

[Term]
id: CHEBI:59874
name: N-acyl-L-alpha-amino acid anion
namespace: chebi_ontology
def: "A carboxylic acid anion that is the conjugate base of an N-acyl-L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." []
subset: 3_STAR
synonym: "an N-acyl-L-amino acid" RELATED [UniProt]
synonym: "N-acyl-L-alpha-amino acid(1-)" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: has_functional_parent CHEBI:59814 ! L-alpha-amino acid anion
relationship: is_conjugate_base_of CHEBI:48927 ! N-acyl-L-alpha-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H2NO3R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "100.05290" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "100.00347" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[C@H]([*])NC([*])=O" xsd:string

[Term]
id: CHEBI:59876
name: N-acyl-D-alpha-amino acid anion
namespace: chebi_ontology
def: "The conjugate base of an N-acyl-D-alpha-amino acid arising from deprotonation of the C-1 carboxy group." []
subset: 3_STAR
synonym: "an N-acyl-D-amino acid" RELATED [UniProt]
synonym: "N-acyl-D-alpha-amino acid(1-)" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:15778 ! N-acyl-D-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H2NO3R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "100.05290" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "100.00347" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[C@@H]([*])NC([*])=O" xsd:string

[Term]
id: CHEBI:59897
name: EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
namespace: chebi_ontology
def: "A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce." []
subset: 3_STAR
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor" RELATED [ChEBI]
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors" RELATED [ChEBI]
synonym: "DNA nucleotidyltransferase (RNA-directed) inhibitor" RELATED [ChEBI]
synonym: "DNA nucleotidyltransferase (RNA-directed) inhibitors" RELATED [ChEBI]
synonym: "EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors" RELATED [ChEBI]
synonym: "EC 2.7.7.49 inhibitor" RELATED [ChEBI]
synonym: "EC 2.7.7.49 inhibitors" RELATED [ChEBI]
synonym: "reverse transcriptase inhibitor" RELATED [ChEBI]
synonym: "reverse transcriptase inhibitors" RELATED [ChEBI]
synonym: "revertase inhibitor" RELATED [ChEBI]
synonym: "revertase inhibitors" RELATED [ChEBI]
synonym: "RNA revertase inhibitor" RELATED [ChEBI]
synonym: "RNA revertase inhibitors" RELATED [ChEBI]
synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI]
synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI]
synonym: "RNA-dependent DNA polymerase inhibitor" RELATED [ChEBI]
synonym: "RNA-dependent DNA polymerase inhibitors" RELATED [ChEBI]
synonym: "RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor" RELATED [ChEBI]
synonym: "RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors" RELATED [ChEBI]
synonym: "RNA-directed DNA polymerase inhibitor" RELATED [ChEBI]
synonym: "RNA-directed DNA polymerase inhibitors" RELATED [ChEBI]
synonym: "RNA-instructed DNA polymerase inhibitor" RELATED [ChEBI]
synonym: "RNA-instructed DNA polymerase inhibitors" RELATED [ChEBI]
synonym: "RT inhibitor" RELATED [ChEBI]
synonym: "RT inhibitors" RELATED [ChEBI]
synonym: "telomerase inhibitor" RELATED [ChEBI]
synonym: "telomerase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Reverse-transcriptase_inhibitor
is_a: CHEBI:22587 ! antiviral agent
is_a: CHEBI:38234 ! DNA polymerase inhibitor

[Term]
id: CHEBI:60038
name: flavonoid oxoanion
namespace: chebi_ontology
def: "Any anion arising from deprotonation of at least one OH group in a flavonoid compound." []
subset: 3_STAR
synonym: "flavonoid oxoanions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
relationship: is_conjugate_base_of CHEBI:47916 ! flavonoid

[Term]
id: CHEBI:60240
name: divalent metal cation
namespace: chebi_ontology
def: "A metal cation with a valence of two." []
subset: 3_STAR
synonym: "a divalent metal cation" RELATED [UniProt]
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:64641 ! divalent inorganic cation

[Term]
id: CHEBI:60242
name: monovalent inorganic cation
namespace: chebi_ontology
def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." []
subset: 3_STAR
synonym: "a monovalent cation" RELATED [UniProt]
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:60251
name: guanidinium ion
namespace: chebi_ontology
def: "R = C or H. The iminium ion resulting from the protonation of one of the imine nitrogens of guanidine or its derivatives." []
subset: 3_STAR
synonym: "diaminomethaniminium ion" RELATED [ChEBI]
synonym: "diaminomethaniminium ions" RELATED [ChEBI]
synonym: "guanidinium ions" RELATED [ChEBI]
is_a: CHEBI:35286 ! iminium ion
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHN3R5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "55.039" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "55.01705" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=[N+]([H])*)(N(*)*)N(*)*" xsd:string

[Term]
id: CHEBI:60466
name: peptide zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." []
subset: 3_STAR
synonym: "a peptide" RELATED [UniProt]
synonym: "peptide zwitterions" RELATED [ChEBI]
is_a: CHEBI:27369 ! zwitterion
relationship: is_tautomer_of CHEBI:16670 ! peptide
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R(C2H2NOR)n" xsd:string

[Term]
id: CHEBI:60809
name: adjuvant
namespace: chebi_ontology
def: "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." []
subset: 3_STAR
synonym: "adjuvants" RELATED [ChEBI]
is_a: CHEBI:52217 ! pharmaceutical

[Term]
id: CHEBI:60832
name: tubulin modulator
namespace: chebi_ontology
def: "Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules." []
subset: 3_STAR
synonym: "tubulin modulators" RELATED [ChEBI]
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:60895
name: D-alpha-amino acid anion
namespace: chebi_ontology
def: "Any alpha-amino acid anion in which the parent amino acid has D-configuration." []
subset: 3_STAR
synonym: "D-alpha-amino acid anions" RELATED [ChEBI]
synonym: "D-alpha-amino carboxylate" RELATED [ChEBI]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: is_conjugate_base_of CHEBI:16733 ! D-alpha-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "73.051" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.01638" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H](C(=O)[O-])(N)*" xsd:string

[Term]
id: CHEBI:61015
name: nephrotoxin
namespace: chebi_ontology
def: "A poison that interferes with the function of the kidneys." []
subset: 3_STAR
synonym: "nephrotoxins" RELATED [ChEBI]
is_a: CHEBI:50909 ! nephrotoxic agent
is_a: CHEBI:64909 ! poison

[Term]
id: CHEBI:61120
name: nucleobase-containing molecular entity
namespace: chebi_ontology
def: "Any compound that has a nucleobase as a part." []
subset: 3_STAR
synonym: "nucleobase-containing compound" RELATED [SUBMITTER]
synonym: "nucleobase-containing compounds" RELATED [ChEBI]
synonym: "nucleobase-containing molecular entities" RELATED [ChEBI]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: has_functional_parent CHEBI:18282 ! nucleobase

[Term]
id: CHEBI:61249
name: hesperetin(1-)
namespace: chebi_ontology
def: "A flavonoid oxoanion that is the conjugate base of hesperetin arising from selective deprtotonation of the 7-hydroxy group." []
subset: 3_STAR
synonym: "(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxochroman-7-olate" EXACT IUPAC_NAME [IUPAC]
synonym: "hesperetin anion" RELATED [ChEBI]
xref: MetaCyc:CPD-7072 {source="SUBMITTER"}
is_a: CHEBI:60038 ! flavonoid oxoanion
relationship: is_conjugate_base_of CHEBI:28230 ! hesperetin
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H13O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/p-1/t14-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AIONOLUJZLIMTK-AWEZNQCLSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "301.27080" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "301.07176" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O)cc([O-])cc2O1" xsd:string

[Term]
id: CHEBI:616459
name: carbamimidoylazanium
namespace: chebi_ontology
subset: 2_STAR
is_a: CHEBI:35359 ! carboxamidine
relationship: is_conjugate_base_of CHEBI:30087 ! guanidinium

[Term]
id: CHEBI:61951
name: microtubule-destabilising agent
namespace: chebi_ontology
def: "Any substance that interacts with tubulin to inhibit polymerisation of microtubules." []
subset: 3_STAR
synonym: "microtubule destabilising agent" RELATED [ChEBI]
synonym: "microtubule destabilising agents" RELATED [ChEBI]
synonym: "microtubule destabilising role" RELATED [ChEBI]
synonym: "microtubule destabilizing role" RELATED [SUBMITTER]
synonym: "microtubule-destabilising agents" RELATED [ChEBI]
synonym: "microtubule-destabilizing agent" RELATED [ChEBI]
synonym: "microtubule-destabilizing agents" RELATED [ChEBI]
xref: PMID:17099073 {source="Europe PMC"}
is_a: CHEBI:60832 ! tubulin modulator
is_a: CHEBI:64911 ! antimitotic

[Term]
id: CHEBI:62031
name: polar amino acid zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." []
subset: 2_STAR
synonym: "a polar amino acid" RELATED [UniProt]
xref: MetaCyc:Polar-amino-acids {source="SUBMITTER"}
is_a: CHEBI:35238 ! amino acid zwitterion
relationship: is_tautomer_of CHEBI:26167 ! polar amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C([O-])=O)(*)[NH3+]" xsd:string

[Term]
id: CHEBI:62081
name: 1,1-diunsubstituted alkanesulfonate
namespace: chebi_ontology
def: "An alkanesulfonate in which the carbon at position 1 is attached to at least two hydrogens." []
subset: 3_STAR
synonym: "1,1-di-unsubstituted alkanesulfonate" RELATED [ChEBI]
synonym: "1,1-di-unsubstituted alkanesulfonates" RELATED [ChEBI]
synonym: "1,1-diunsubstituted alkanesulfonates" RELATED [ChEBI]
xref: KEGG:C15521
xref: MetaCyc:Alkanesulfonates
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:134249 ! alkanesulfonate oxoanion
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O3SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "94.09000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "93.97246" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([H])([*])S([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:62501
name: folate(2-)
namespace: chebi_ontology
def: "The dicarboxylic acid dianion formed from folic acid by loss of a proton from each of the two carboxy groups in the glutamic acid moiety." []
subset: 3_STAR
synonym: "folate" RELATED [UniProt]
synonym: "folate" RELATED [MetaCyc]
synonym: "N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "pteroyl-L-glutamate" RELATED [ChEBI]
synonym: "pteroyl-L-monoglutamate" RELATED [ChEBI]
synonym: "pteroylglutamate" RELATED [ChEBI]
xref: MetaCyc:CPD-12826 {source="SUBMITTER"}
xref: PMCID:PMC8181341 {source="Europe PMC"}
xref: PMID:34051149 {source="Europe PMC"}
is_a: CHEBI:28965 ! dicarboxylic acid dianion
is_a: CHEBI:67011 ! folates
relationship: is_conjugate_base_of CHEBI:27470 ! folic acid
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H17N7O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/p-2/t12-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OVBPIULPVIDEAO-LBPRGKRZSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "439.38160" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "439.12513" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)nc2c(=O)[nH]1" xsd:string

[Term]
id: CHEBI:62803
name: fuel additive
namespace: chebi_ontology
def: "Any additive that enhances the efficiency of fuel." []
subset: 3_STAR
synonym: "fuel additives" RELATED [ChEBI]
synonym: "fuel enhancer" RELATED [ChEBI]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:63161
name: glycosyl compound
namespace: chebi_ontology
def: "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." []
subset: 3_STAR
synonym: "glycosyl compounds" RELATED [ChEBI]
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:63299
name: carbohydrate derivative
namespace: chebi_ontology
def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." []
subset: 3_STAR
synonym: "carbohydrate derivatives" RELATED [ChEBI]
synonym: "derivatised carbohydrate" RELATED [ChEBI]
synonym: "derivatised carbohydrates" RELATED [ChEBI]
synonym: "derivatized carbohydrate" RELATED [ChEBI]
synonym: "derivatized carbohydrates" RELATED [ChEBI]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
relationship: has_functional_parent CHEBI:16646 ! carbohydrate

[Term]
id: CHEBI:63332
name: EC 3.1.3.1 (alkaline phosphatase) inhibitor
namespace: chebi_ontology
def: "An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of alkaline phosphatase (EC 3.1.3.1)." []
subset: 3_STAR
synonym: "alkaline phenyl phosphatase inhibitor" RELATED [ChEBI]
synonym: "alkaline phenyl phosphatase inhibitors" RELATED [ChEBI]
synonym: "alkaline phosphatase (EC 3.1.3.1) inhibitor" RELATED [ChEBI]
synonym: "alkaline phosphatase (EC 3.1.3.1) inhibitors" RELATED [ChEBI]
synonym: "alkaline phosphatase inhibitor" RELATED [ChEBI]
synonym: "alkaline phosphatase inhibitors" RELATED [ChEBI]
synonym: "alkaline phosphohydrolase inhibitor" RELATED [ChEBI]
synonym: "alkaline phosphohydrolase inhibitors" RELATED [ChEBI]
synonym: "alkaline phosphomonoesterase inhibitor" RELATED [ChEBI]
synonym: "alkaline phosphomonoesterase inhibitors" RELATED [ChEBI]
synonym: "EC 3.1.3.1 (alkaline phosphatase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.1.3.1 inhibitor" RELATED [ChEBI]
synonym: "EC 3.1.3.1 inhibitors" RELATED [ChEBI]
synonym: "glycerophosphatase inhibitor" RELATED [ChEBI]
synonym: "glycerophosphatase inhibitors" RELATED [ChEBI]
synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitor" RELATED [ChEBI]
synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitors" RELATED [ChEBI]
synonym: "phosphate-monoester phosphohydrolase (alkaline optimum) inhibitor" RELATED [ChEBI]
synonym: "phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors" RELATED [ChEBI]
synonym: "phosphomonoesterase inhibitor" RELATED [ChEBI]
synonym: "phosphomonoesterase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Alkaline_phosphatase
is_a: CHEBI:76775 ! EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor

[Term]
id: CHEBI:63353
name: disaccharide derivative
namespace: chebi_ontology
def: "A carbohydrate derivative that is formally obtained from a disaccharide." []
subset: 3_STAR
synonym: "disaccharide derivatives" RELATED [ChEBI]
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: has_functional_parent CHEBI:36233 ! disaccharide

[Term]
id: CHEBI:63470
name: sulfur-containing amino-acid anion
namespace: chebi_ontology
def: "A sulfur-containing amino acid whose alpha-carboxylic acid group is ionized (not protonated)." []
subset: 3_STAR
synonym: "sulfur-containing amino-acid anions" RELATED [ChEBI]
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:26834 ! sulfur-containing amino acid

[Term]
id: CHEBI:63473
name: aromatic amino-acid anion
namespace: chebi_ontology
def: "An aromatic amino acid whose alpha-carboxylic acid group is ionized (non-protonated)." []
subset: 3_STAR
synonym: "aromatic amino-acid anions" RELATED [ChEBI]
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:33856 ! aromatic amino acid

[Term]
id: CHEBI:63490
name: explosive
namespace: chebi_ontology
def: "A substance capable of undergoing rapid and highly exothermic decomposition." []
subset: 3_STAR
synonym: "explosive compound" RELATED [ChEBI]
synonym: "explosive compounds" RELATED [ChEBI]
synonym: "explosive material" RELATED [ChEBI]
synonym: "explosives" RELATED [ChEBI]
synonym: "explosives chemical" RELATED [ChEBI]
synonym: "explosives chemicals" RELATED [ChEBI]
xref: Wikipedia:Explosive_material
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:63624
name: telbivudine
namespace: chebi_ontology
def: "A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase." []
subset: 3_STAR
synonym: "1-(2-deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC]
synonym: "1-(2-deoxy-beta-L-ribofuranosyl)-5-methyluracil" RELATED [ChEBI]
synonym: "2'-Deoxy-L-thymidine" RELATED [DrugBank]
synonym: "beta-L-2'-deoxythymidine" RELATED [ChEBI]
synonym: "Beta-l-thymidine" RELATED [DrugBank]
synonym: "Epavudine" RELATED [DrugBank]
synonym: "L-deoxythymidine" RELATED [DrugBank]
synonym: "L-DT" RELATED [DrugBank]
synonym: "L-thymidine" RELATED [DrugBank]
synonym: "LDT" RELATED [DrugBank]
synonym: "telbivudine" RELATED INN [KEGG_DRUG]
xref: CAS:3424-98-4 {source="ChemIDplus"}
xref: Drug_Central:4220 {source="DrugCentral"}
xref: DrugBank:DB01265
xref: KEGG:D06675
xref: PMID:21040410 {source="Europe PMC"}
xref: PMID:21147187 {source="Europe PMC"}
xref: PMID:21457439 {source="Europe PMC"}
xref: PMID:21586234 {source="Europe PMC"}
xref: PMID:21642814 {source="Europe PMC"}
xref: PMID:21670922 {source="Europe PMC"}
xref: PMID:21703206 {source="Europe PMC"}
xref: PMID:21748522 {source="Europe PMC"}
xref: PMID:22093034 {source="Europe PMC"}
xref: PMID:22132702 {source="Europe PMC"}
xref: PMID:22174039 {source="Europe PMC"}
xref: PMID:22233255 {source="Europe PMC"}
xref: PMID:22257108 {source="Europe PMC"}
xref: Reaxys:754297 {source="Reaxys"}
xref: Wikipedia:Telbivudine
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside
relationship: has_functional_parent CHEBI:17821 ! thymine
relationship: is_enantiomer_of CHEBI:17748 ! thymidine
relationship: RO:0000087 CHEBI:36044 ! has role antiviral drug
relationship: RO:0000087 CHEBI:59897 ! has role EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H14N2O5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IQFYYKKMVGJFEH-CSMHCCOUSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "242.22860" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "242.09027" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O" xsd:string

[Term]
id: CHEBI:64047
name: food additive
namespace: chebi_ontology
def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." []
subset: 3_STAR
synonym: "food additives" RELATED [ChEBI]
xref: Wikipedia:Food_additive
is_a: CHEBI:33232 ! application
is_a: CHEBI:78295 ! food component

[Term]
id: CHEBI:64382
name: organosulfonate salt
namespace: chebi_ontology
def: "Any organic salt prepared using an organosulfonic acid as the acid component." []
subset: 3_STAR
synonym: "organosulfonate salts" RELATED [ChEBI]
synonym: "organosulphonate salt" RELATED [ChEBI]
synonym: "organosulphonate salts" RELATED [ChEBI]
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:33261 ! organosulfur compound

[Term]
id: CHEBI:64577
name: flour treatment agent
namespace: chebi_ontology
def: "A food additive which is added to flour or dough to improve baking quality and/or colour." []
subset: 3_STAR
synonym: "dough improver" RELATED [ChEBI]
synonym: "dough improvers" RELATED [ChEBI]
synonym: "flour treatment agent" EXACT [ChEBI]
synonym: "improving agent" RELATED [ChEBI]
synonym: "improving agents" RELATED [ChEBI]
xref: Wikipedia:Flour_treatment_agent
is_a: CHEBI:64047 ! food additive

[Term]
id: CHEBI:64641
name: divalent inorganic cation
namespace: chebi_ontology
def: "An inorganic cation with a valency of two." []
subset: 3_STAR
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:64708
name: one-carbon compound
namespace: chebi_ontology
def: "An organic molecular entity containing a single carbon atom (C1)." []
subset: 3_STAR
synonym: "one-carbon compounds" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:64709
name: organic acid
namespace: chebi_ontology
def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." []
subset: 3_STAR
synonym: "organic acids" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:64857
name: cosmetic
namespace: chebi_ontology
def: "The role played by a substance in enhancing the appearance or odour of the human body; a name given to the substance itself or to a component of it." []
subset: 3_STAR
synonym: "cosmetic component" RELATED [ChEBI]
synonym: "cosmetics" RELATED [ChEBI]
xref: Wikipedia:Cosmetics
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:64909
name: poison
namespace: chebi_ontology
def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." []
subset: 3_STAR
synonym: "poisonous agent" RELATED [ChEBI]
synonym: "poisonous agents" RELATED [ChEBI]
synonym: "poisonous substance" RELATED [ChEBI]
synonym: "poisonous substances" RELATED [ChEBI]
synonym: "poisons" RELATED [ChEBI]
synonym: "toxic agent" RELATED [ChEBI]
synonym: "toxic agents" RELATED [ChEBI]
synonym: "toxic substance" RELATED [ChEBI]
synonym: "toxic substances" RELATED [ChEBI]
xref: Wikipedia:Poison
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:64911
name: antimitotic
namespace: chebi_ontology
def: "Any compound that inhibits cell division (mitosis)." []
subset: 3_STAR
synonym: "antimitotics" RELATED [ChEBI]
synonym: "mitosis inhibitor" RELATED [ChEBI]
synonym: "mitosis inhibitors" RELATED [ChEBI]
synonym: "mitotic inhibitor" RELATED [ChEBI]
synonym: "mitotic inhibitors" RELATED [ChEBI]
xref: Wikipedia:Mitotic_inhibitor
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:64915
name: antiplasmodial drug
namespace: chebi_ontology
def: "An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria." []
subset: 3_STAR
synonym: "antiplasmodial agent" RELATED [ChEBI]
synonym: "antiplasmodial agents" RELATED [ChEBI]
synonym: "antiplasmodial drugs" RELATED [ChEBI]
synonym: "antiplasmodium agent" RELATED [ChEBI]
synonym: "antiplasmodium agents" RELATED [ChEBI]
synonym: "antiplasmodium drug" RELATED [ChEBI]
synonym: "antiplasmodium drugs" RELATED [ChEBI]
is_a: CHEBI:35820 ! antiprotozoal drug

[Term]
id: CHEBI:67011
name: folates
namespace: chebi_ontology
def: "An N-acyl-L-alpha-amino acid anion obtained by deprotonation of any folic acid." []
subset: 3_STAR
synonym: "folate" RELATED [ChEBI]
synonym: "folate anion" RELATED [ChEBI]
synonym: "folate anions" RELATED [ChEBI]
is_a: CHEBI:176842 ! vitamin B9
is_a: CHEBI:59874 ! N-acyl-L-alpha-amino acid anion
relationship: is_conjugate_base_of CHEBI:37445 ! folic acids

[Term]
id: CHEBI:67105
name: insect sterilant
namespace: chebi_ontology
def: "A chemosterilant intended to sterilize insects." []
subset: 3_STAR
synonym: "insect chemosterilant" RELATED [ChEBI]
synonym: "insect chemosterilants" RELATED [ChEBI]
synonym: "insect sterilants" RELATED [ChEBI]
is_a: CHEBI:23092 ! chemosterilant
is_a: CHEBI:24852 ! insecticide

[Term]
id: CHEBI:67107
name: dimethylmyleran
namespace: chebi_ontology
def: "A methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups." []
subset: 3_STAR
synonym: "1,4-bis(methylsulfonyloxy)-1,4-dimethylbutane" RELATED [ChemIDplus]
synonym: "1,4-dimethanesulfonoxy-1,4-dimethylbutane" RELATED [ChemIDplus]
synonym: "1,4-dimethylbusulfan" RELATED [ChEBI]
synonym: "1,4-dimethylmyleran" RELATED [ChEBI]
synonym: "2,5-dimethanesulfomyloxyhexane" RELATED [ChemIDplus]
synonym: "2,5-hexanediol dimesylate" RELATED [ChEBI]
synonym: "2,5-hexanediol dimethylsulfonate" RELATED [ChemIDplus]
synonym: "dimethylbusulfan" RELATED [ChemIDplus]
synonym: "DMM" RELATED [ChemIDplus]
synonym: "hexane-2,5-diyl dimethanesulfonate" EXACT IUPAC_NAME [IUPAC]
xref: CAS:55-93-6 {source="ChemIDplus"}
xref: PMID:3800321 {source="Europe PMC"}
xref: Reaxys:1796040 {source="Reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25223 ! methanesulfonate ester
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H18O6S2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H18O6S2/c1-7(13-15(3,9)10)5-6-8(2)14-16(4,11)12/h7-8H,5-6H2,1-4H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JDZNTUQRMDAIRO-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "274.35500" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "274.05448" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(CCC(C)OS(C)(=O)=O)OS(C)(=O)=O" xsd:string

[Term]
id: CHEBI:67114
name: ryanodine receptor agonist
namespace: chebi_ontology
def: "A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction." []
subset: 3_STAR
synonym: "ryanodine receptor activator" RELATED [ChEBI]
synonym: "ryanodine receptor activators" RELATED [ChEBI]
synonym: "RyR activator" RELATED [ChEBI]
synonym: "RyR activators" RELATED [ChEBI]
synonym: "RyR agonist" RELATED [ChEBI]
synonym: "RyR agonists" RELATED [ChEBI]
synonym: "RyRs activator" RELATED [ChEBI]
synonym: "RyRs agonist" RELATED [ChEBI]
xref: PMID:30679133 {source="Europe PMC"}
xref: PMID:30684528 {source="Europe PMC"}
xref: PMID:31840405 {source="Europe PMC"}
xref: PMID:8597061 {source="Europe PMC"}
xref: Wikipedia:Ryanodine_receptor
is_a: CHEBI:38809 ! ryanodine receptor modulator

[Term]
id: CHEBI:67141
name: hycanthone(1+)
namespace: chebi_ontology
def: "An ammonium ion resulting from the protonation of the tertiary amino group of lycanthone." []
subset: 3_STAR
synonym: "N,N-diethyl-2-{[4-(hydroxymethyl)-10-oxo-10H-dibenzo[b,e]thiopyran-1-yl]amino}ethanaminium" EXACT IUPAC_NAME [IUPAC]
xref: Reaxys:19574704 {source="Reaxys"}
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: is_conjugate_acid_of CHEBI:52768 ! hycanthone
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H25N2O2S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MFZWMTSUNYWVBU-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "357.49000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "357.16313" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[NH+](CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12" xsd:string

[Term]
id: CHEBI:67142
name: nucleobase analogue
namespace: chebi_ontology
def: "A molecule that can substitute for a normal nucleobase in nucleic acids." []
subset: 3_STAR
synonym: "base analog" RELATED [ChEBI]
synonym: "base analogs" RELATED [ChEBI]
synonym: "base analogue" RELATED [ChEBI]
synonym: "base analogues" RELATED [ChEBI]
synonym: "nucleobase analog" RELATED [ChEBI]
synonym: "nucleobase analogs" RELATED [ChEBI]
synonym: "nucleobase analogues" RELATED [ChEBI]
xref: Wikipedia:Base_analog
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:68472
name: pyrimidine deoxyribonucleoside
namespace: chebi_ontology
def: "A deoxyribonucleoside containing a pyrimidine base." []
subset: 3_STAR
synonym: "pyrimidine deoxyribonucleosides" RELATED [ChEBI]
xref: MetaCyc:Pyrimidine-Deoxyribonucleosides
is_a: CHEBI:23636 ! deoxyribonucleoside
is_a: CHEBI:26440 ! pyrimidine nucleoside

[Term]
id: CHEBI:68494
name: apoptosis inhibitor
namespace: chebi_ontology
def: "Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms." []
subset: 3_STAR
synonym: "apoptosis inhibitors" RELATED [ChEBI]
synonym: "Type I cell-death inhibitor" RELATED [ChEBI]
synonym: "Type I cell-death inhibitors" RELATED [ChEBI]
synonym: "Type I programmed cell-death inhibitor" RELATED [ChEBI]
synonym: "Type I programmed cell-death inhibitors" RELATED [ChEBI]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:68495
name: apoptosis inducer
namespace: chebi_ontology
def: "Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms." []
subset: 3_STAR
synonym: "apoptosis inducers" RELATED [ChEBI]
synonym: "Type I cell-death inducer" RELATED [ChEBI]
synonym: "Type I cell-death inducers" RELATED [ChEBI]
synonym: "Type I programmed cell-death inducer" RELATED [ChEBI]
synonym: "Type I programmed cell-death inducers" RELATED [ChEBI]
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:70727
name: topoisomerase inhibitor
namespace: chebi_ontology
def: "An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA)." []
subset: 3_STAR
synonym: "topoisomerase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Topoisomerase
is_a: CHEBI:76830 ! EC 5.99.1.* (miscellaneous isomerase) inhibitor

[Term]
id: CHEBI:71232
name: adenosine receptor antagonist
namespace: chebi_ontology
def: "An antagonist at any adenosine receptor." []
subset: 3_STAR
synonym: "adenosine receptor antagonists" RELATED [ChEBI]
xref: Wikipedia:Adenosine_receptor
is_a: CHEBI:48706 ! antagonist

[Term]
id: CHEBI:71300
name: EC 2.* (transferase) inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)" []
subset: 3_STAR
synonym: "EC 2 inhibitor" RELATED [ChEBI]
synonym: "EC 2 inhibitors" RELATED [ChEBI]
synonym: "EC 2.* (transferase) inhibitors" RELATED [ChEBI]
synonym: "EC 2.* inhibitor" RELATED [ChEBI]
synonym: "EC 2.* inhibitors" RELATED [ChEBI]
synonym: "transferase inhibitor" RELATED [ChEBI]
synonym: "transferase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Transferase
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:72544
name: flavonoids
namespace: chebi_ontology
def: "Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them." []
subset: 3_STAR
synonym: "flavonoid" RELATED [ChEBI]
xref: Wikipedia:Flavonoids
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:72695
name: organic molecule
namespace: chebi_ontology
def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." []
subset: 3_STAR
synonym: "organic compound" RELATED [ChEBI]
synonym: "organic compounds" RELATED [ChEBI]
synonym: "organic molecules" RELATED [ChEBI]
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:72730
name: flavanone glycoside
namespace: chebi_ontology
def: "A member of the class of flavanones having one or more glycosyl residues attached at unspecified positions." []
subset: 3_STAR
synonym: "flavanone glycosides" RELATED [ChEBI]
is_a: CHEBI:24400 ! glycoside
is_a: CHEBI:28863 ! flavanones

[Term]
id: CHEBI:73690
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid
namespace: chebi_ontology
def: "An L-alpha-amino acid which is biosynthesised from erythrose 4-phosphate and phosphoenolpyruvate (i.e. phenylalanine, tyrosine, and tryptophan). A closed class." []
subset: 3_STAR
synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acid" RELATED [ChEBI]
synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acids" RELATED [ChEBI]
synonym: "erythrose 4-phosphate family amino acid" RELATED [ChEBI]
synonym: "erythrose 4-phosphate family amino acids" RELATED [ChEBI]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acids" RELATED [ChEBI]
synonym: "phosphoenolpyruvate family amino acid" RELATED [ChEBI]
synonym: "phosphoenolpyruvate family amino acids" RELATED [ChEBI]
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83813 ! proteinogenic amino acid

[Term]
id: CHEBI:73913
name: antifolate
namespace: chebi_ontology
def: "An antimetabolite that impairs the action of folic acids" []
subset: 3_STAR
synonym: "antifolates" RELATED [ChEBI]
synonym: "folic acid antagonist" RELATED [ChEBI]
synonym: "folic acid antagonists" RELATED [ChEBI]
xref: Wikipedia:Antifolate
is_a: CHEBI:35221 ! antimetabolite

[Term]
id: CHEBI:74783
name: astringent
namespace: chebi_ontology
def: "A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions." []
subset: 3_STAR
synonym: "adstringent" RELATED [ChEBI]
synonym: "adstringents" RELATED [ChEBI]
synonym: "astringents" RELATED [ChEBI]
xref: Wikipedia:Astringent
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:75596
name: EC 5.* (isomerase) inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*)." []
subset: 3_STAR
synonym: "EC 5.* (isomerase) inhibitors" RELATED [ChEBI]
synonym: "EC 5.* inhibitor" RELATED [ChEBI]
synonym: "EC 5.* inhibitors" RELATED [ChEBI]
synonym: "EC 5.*.*.* inhibitor" RELATED [ChEBI]
synonym: "EC 5.*.*.* inhibitors" RELATED [ChEBI]
synonym: "isomerase (EC 5.*) inhibitor" RELATED [ChEBI]
synonym: "isomerase (EC 5.*) inhibitors" RELATED [ChEBI]
synonym: "isomerase inhibitor" RELATED [ChEBI]
synonym: "isomerase inhibitors" RELATED [ChEBI]
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:75600
name: EC 6.3.* (C-N bond-forming ligase) inhibitor
namespace: chebi_ontology
def: "A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*)." []
subset: 3_STAR
synonym: "C--N bond-forming ligase inhibitor" RELATED [ChEBI]
synonym: "C--N bond-forming ligase inhibitors" RELATED [ChEBI]
synonym: "C-N bond-forming ligase (EC 6.3.*) inhibitor" RELATED [ChEBI]
synonym: "C-N bond-forming ligase (EC 6.3.*) inhibitors" RELATED [ChEBI]
synonym: "C-N bond-forming ligase inhibitor" RELATED [ChEBI]
synonym: "C-N bond-forming ligase inhibitors" RELATED [ChEBI]
synonym: "EC 6.3.* (C-N bond-forming ligase) inhibitorS" RELATED [ChEBI]
synonym: "EC 6.3.* inhibitor" RELATED [ChEBI]
synonym: "EC 6.3.* inhibitors" RELATED [ChEBI]
synonym: "EC 6.3.*.* inhibitor" RELATED [ChEBI]
synonym: "EC 6.3.*.* inhibitors" RELATED [ChEBI]
is_a: CHEBI:75603 ! EC 6.* (ligase) inhibitor

[Term]
id: CHEBI:75603
name: EC 6.* (ligase) inhibitor
namespace: chebi_ontology
def: "Any enzyme inhibitor that interferes with the action of a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." []
subset: 3_STAR
synonym: "EC 6.* (ligase) inhibitors" RELATED [ChEBI]
synonym: "EC 6.* inhibitor" RELATED [ChEBI]
synonym: "EC 6.* inhibitors" RELATED [ChEBI]
synonym: "EC 6.*.*.* inhibitor" RELATED [ChEBI]
synonym: "EC 6.*.*.* inhibitors" RELATED [ChEBI]
synonym: "ligase inhibitor" RELATED [ChEBI]
synonym: "ligase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Ligase
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:75763
name: eukaryotic metabolite
namespace: chebi_ontology
def: "Any  metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." []
subset: 3_STAR
synonym: "eukaryotic metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:75767
name: animal metabolite
namespace: chebi_ontology
alt_id: CHEBI:77721
alt_id: CHEBI:77743
def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." []
subset: 3_STAR
synonym: "animal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:75768
name: mammalian metabolite
namespace: chebi_ontology
alt_id: CHEBI:77464
alt_id: CHEBI:77744
def: "Any animal metabolite produced during a metabolic reaction in mammals." []
subset: 3_STAR
synonym: "mammalian metabolites" RELATED [ChEBI]
is_a: CHEBI:75767 ! animal metabolite

[Term]
id: CHEBI:75769
name: B vitamin
namespace: chebi_ontology
def: "Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such)." []
subset: 3_STAR
synonym: "B vitamins" RELATED [ChEBI]
synonym: "B-group vitamin" RELATED [ChEBI]
synonym: "B-group vitamins" RELATED [ChEBI]
synonym: "vitamin B" RELATED [ChEBI]
xref: MetaCyc:B-vitamins
xref: PMID:22743781 {source="Europe PMC"}
xref: PMID:23093174 {source="Europe PMC"}
xref: PMID:23238962 {source="Europe PMC"}
xref: PMID:23449527 {source="Europe PMC"}
xref: PMID:23462586 {source="Europe PMC"}
xref: PMID:23690582 {source="Europe PMC"}
xref: Wikipedia:B_vitamin
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: RO:0000087 CHEBI:27314 ! has role water-soluble vitamin (role)
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical

[Term]
id: CHEBI:75771
name: mouse metabolite
namespace: chebi_ontology
def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." []
subset: 3_STAR
synonym: "mouse metabolites" RELATED [ChEBI]
synonym: "Mus musculus metabolite" RELATED [ChEBI]
synonym: "Mus musculus metabolites" RELATED [ChEBI]
is_a: CHEBI:75768 ! mammalian metabolite

[Term]
id: CHEBI:75772
name: Saccharomyces cerevisiae metabolite
namespace: chebi_ontology
alt_id: CHEBI:76949
alt_id: CHEBI:76951
def: "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." []
subset: 3_STAR
synonym: "baker's yeast metabolite" RELATED [ChEBI]
synonym: "baker's yeast metabolites" RELATED [ChEBI]
synonym: "baker's yeast secondary metabolite" RELATED [ChEBI]
synonym: "baker's yeast secondary metabolites" RELATED [ChEBI]
synonym: "S. cerevisiae metabolite" RELATED [ChEBI]
synonym: "S. cerevisiae metabolites" RELATED [ChEBI]
synonym: "S. cerevisiae secondary metabolite" RELATED [ChEBI]
synonym: "S. cerevisiae secondary metabolites" RELATED [ChEBI]
synonym: "Saccharomyces cerevisiae metabolites" RELATED [ChEBI]
synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [ChEBI]
is_a: CHEBI:76946 ! fungal metabolite

[Term]
id: CHEBI:75787
name: prokaryotic metabolite
namespace: chebi_ontology
def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." []
subset: 3_STAR
synonym: "prokaryotic metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:76042
name: aromatic amino-acid zwitterion
namespace: chebi_ontology
def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid." []
subset: 3_STAR
synonym: "an aromatic amino-acid" RELATED [UniProt]
synonym: "aromatic amino-acid zwitterions" RELATED [ChEBI]
xref: MetaCyc:Aromatic-Amino-Acids {source="SUBMITTER"}
is_a: CHEBI:35238 ! amino acid zwitterion
relationship: is_tautomer_of CHEBI:33856 ! aromatic amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C([*])C([O-])=O" xsd:string

[Term]
id: CHEBI:76206
name: xenobiotic metabolite
namespace: chebi_ontology
def: "Any metabolite produced by metabolism of a xenobiotic compound." []
subset: 3_STAR
synonym: "xenobiotic metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:76414
name: propellant
namespace: chebi_ontology
def: "A compressed gas or liquid with a boiling point lower than room temperature which to used to propel and dispense liquids such as deodorants, insecticides, paints, etc. from aerosol cans." []
subset: 3_STAR
synonym: "propellants" RELATED [ChEBI]
xref: PMID:22519407 {source="Europe PMC"}
xref: PMID:24001847 {source="Europe PMC"}
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:76507
name: marine metabolite
namespace: chebi_ontology
alt_id: CHEBI:77078
def: "Any metabolite produced during a metabolic reaction in marine macro- and microorganisms." []
subset: 3_STAR
synonym: "marine metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:76551
name: N-nitrosoureas
namespace: chebi_ontology
def: "A nitroso compound that is any urea in which one of the nitrogens is substituted by a nitroso group" []
subset: 3_STAR
is_a: CHEBI:35800 ! nitroso compound
is_a: CHEBI:47857 ! ureas

[Term]
id: CHEBI:76668
name: EC 2.7.* (P-containing group transferase) inhibitor
namespace: chebi_ontology
def: "A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*)." []
subset: 3_STAR
synonym: "EC 2.7.* (P-containing group transferase) inhibitors" RELATED [ChEBI]
synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitor" RELATED [ChEBI]
synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitors" RELATED [ChEBI]
synonym: "EC 2.7.* inhibitor" RELATED [ChEBI]
synonym: "EC 2.7.* inhibitors" RELATED [ChEBI]
synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitor" RELATED [ChEBI]
synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitors" RELATED [ChEBI]
synonym: "phosphorus-containing group transferase inhibitor" RELATED [ChEBI]
synonym: "phosphorus-containing group transferase inhibitors" RELATED [ChEBI]
is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor

[Term]
id: CHEBI:76697
name: EC 5.99.* (other isomerases) inhibitor
namespace: chebi_ontology
def: "An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*)." []
subset: 3_STAR
synonym: "EC 5.99.* (miscellaneous isomerases) inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.* (miscellaneous isomerases) inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.* (other isomerase) inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.* (other isomerase) inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.* (other isomerases) inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.* inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.* inhibitors" RELATED [ChEBI]
is_a: CHEBI:75596 ! EC 5.* (isomerase) inhibitor

[Term]
id: CHEBI:76725
name: EC 1.* (oxidoreductase) inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." []
subset: 3_STAR
synonym: "EC 1.* (oxidoreductase) inhibitors" RELATED [ChEBI]
synonym: "EC 1.* inhibitor" RELATED [ChEBI]
synonym: "EC 1.* inhibitors" RELATED [ChEBI]
synonym: "oxidoreductase (EC 1.*) inhibitor" RELATED [ChEBI]
synonym: "oxidoreductase (EC 1.*) inhibitors" RELATED [ChEBI]
synonym: "oxidoreductase inhibitor" RELATED [ChEBI]
synonym: "oxidoreductase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Oxidoreductase
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:76731
name: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*)." []
subset: 3_STAR
synonym: "EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors" RELATED [ChEBI]
synonym: "EC 1.5.* inhibitor" RELATED [ChEBI]
synonym: "EC 1.5.* inhibitors" RELATED [ChEBI]
synonym: "inhibitor of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI]
synonym: "inhibitor of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI]
synonym: "inhibitors of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI]
synonym: "inhibitors of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI]
synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor" RELATED [ChEBI]
synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors" RELATED [ChEBI]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76735
name: EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase of class EC 1.8.*.* (acting on a sulfur group of donors)." []
subset: 3_STAR
synonym: "EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors" RELATED [ChEBI]
synonym: "EC 1.8.* inhibitor" RELATED [ChEBI]
synonym: "EC 1.8.* inhibitors" RELATED [ChEBI]
synonym: "oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor" RELATED [ChEBI]
synonym: "oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors" RELATED [ChEBI]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76759
name: EC 3.* (hydrolase) inhibitor
namespace: chebi_ontology
def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." []
subset: 3_STAR
synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.* inhibitors" RELATED [ChEBI]
synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI]
synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI]
synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI]
synonym: "hydrolase inhibitor" RELATED [ChEBI]
synonym: "hydrolase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Hydrolase
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:76760
name: EC 3.1.* (ester hydrolase) inhibitor
namespace: chebi_ontology
def: "A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*)." []
subset: 3_STAR
synonym: "EC 3.1.* (ester hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.1.* inhibitors" RELATED [ChEBI]
synonym: "ester hydrolase (EC 3.1.*) inhibitor" RELATED [ChEBI]
synonym: "ester hydrolase (EC 3.1.*) inhibitors" RELATED [ChEBI]
synonym: "ester hydrolase inhibitor" RELATED [ChEBI]
synonym: "ester hydrolase inhibitors" RELATED [ChEBI]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor

[Term]
id: CHEBI:76764
name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
namespace: chebi_ontology
def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." []
subset: 3_STAR
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* inhibitors" RELATED [ChEBI]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor

[Term]
id: CHEBI:76775
name: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
namespace: chebi_ontology
def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*)." []
subset: 3_STAR
synonym: "EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.1.3.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.1.3.* inhibitors" RELATED [ChEBI]
synonym: "inhibitor of phosphoric monoester hydrolase" RELATED [ChEBI]
synonym: "inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI]
synonym: "inhibitors of phosphoric monoester hydrolase" RELATED [ChEBI]
synonym: "inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI]
synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor" RELATED [ChEBI]
synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors" RELATED [ChEBI]
synonym: "phosphoric monoester hydrolase inhibitor" RELATED [ChEBI]
synonym: "phosphoric monoester hydrolase inhibitors" RELATED [ChEBI]
is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor

[Term]
id: CHEBI:76807
name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." []
subset: 3_STAR
synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.1.* inhibitors" RELATED [ChEBI]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [ChEBI]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI]
is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor

[Term]
id: CHEBI:76812
name: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*)." []
subset: 3_STAR
synonym: "EC 2.7.11.* (protein-serine/threonine kinase) inhibitors" RELATED [ChEBI]
synonym: "EC 2.7.11.* inhibitor" RELATED [ChEBI]
synonym: "EC 2.7.11.* inhibitors" RELATED [ChEBI]
synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitor" RELATED [ChEBI]
synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitors" RELATED [ChEBI]
synonym: "protein-serine/threonine kinase inhibitor" RELATED [ChEBI]
synonym: "protein-serine/threonine kinase inhibitors" RELATED [ChEBI]
is_a: CHEBI:37699 ! protein kinase inhibitor

[Term]
id: CHEBI:76815
name: EC 2.7.7.* (nucleotidyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*)." []
subset: 3_STAR
synonym: "EC 2.7.7.* (nucleotidyltransferase) inhibitors" RELATED [ChEBI]
synonym: "inhibitor of nucleotidyltransferases" RELATED [ChEBI]
synonym: "inhibitor of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI]
synonym: "inhibitors of nucleotidyltransferases" RELATED [ChEBI]
synonym: "inhibitors of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI]
synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitor" RELATED [ChEBI]
synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitors" RELATED [ChEBI]
synonym: "nucleotidyltransferase inhibitor" RELATED [ChEBI]
synonym: "nucleotidyltransferase inhibitors" RELATED [ChEBI]
is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor

[Term]
id: CHEBI:76823
name: EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
namespace: chebi_ontology
def: "An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)." []
subset: 3_STAR
synonym: "acid-ammonia (or amine) ligase inhibitor" RELATED [ChEBI]
synonym: "acid-ammonia (or amine) ligase inhibitors" RELATED [ChEBI]
synonym: "EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors" RELATED [ChEBI]
synonym: "EC 6.3.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 6.3.1.* inhibitors" RELATED [ChEBI]
is_a: CHEBI:75600 ! EC 6.3.* (C-N bond-forming ligase) inhibitor

[Term]
id: CHEBI:76830
name: EC 5.99.1.* (miscellaneous isomerase) inhibitor
namespace: chebi_ontology
def: "An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class." []
subset: 3_STAR
synonym: "EC 5.99.1.* (miscellaneous isomerase) inhibitors" RELATED [ChEBI]
synonym: "EC 5.99.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 5.99.1.* inhibitors" RELATED [ChEBI]
is_a: CHEBI:76697 ! EC 5.99.* (other isomerases) inhibitor

[Term]
id: CHEBI:76863
name: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*)." []
subset: 3_STAR
synonym: "EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI]
synonym: "EC 1.5.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 1.5.1.* inhibitors" RELATED [ChEBI]
synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor" RELATED [ChEBI]
synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors" RELATED [ChEBI]
is_a: CHEBI:76731 ! EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor

[Term]
id: CHEBI:76869
name: EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.8.1.*)." []
subset: 3_STAR
synonym: "EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI]
synonym: "EC 1.8.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 1.8.1.* inhibitors" RELATED [ChEBI]
synonym: "oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor" RELATED [ChEBI]
synonym: "oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors" RELATED [ChEBI]
is_a: CHEBI:76735 ! EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor

[Term]
id: CHEBI:76924
name: plant metabolite
namespace: chebi_ontology
alt_id: CHEBI:75766
alt_id: CHEBI:76925
def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." []
subset: 3_STAR
synonym: "plant metabolites" RELATED [ChEBI]
synonym: "plant secondary metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:76946
name: fungal metabolite
namespace: chebi_ontology
alt_id: CHEBI:75765
alt_id: CHEBI:76947
def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." []
subset: 3_STAR
synonym: "fungal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:76967
name: human xenobiotic metabolite
namespace: chebi_ontology
def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." []
subset: 3_STAR
synonym: "human xenobiotic metabolites" RELATED [ChEBI]
is_a: CHEBI:76206 ! xenobiotic metabolite
is_a: CHEBI:77746 ! human metabolite

[Term]
id: CHEBI:76969
name: bacterial metabolite
namespace: chebi_ontology
alt_id: CHEBI:75760
alt_id: CHEBI:76970
def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." []
subset: 3_STAR
is_a: CHEBI:75787 ! prokaryotic metabolite

[Term]
id: CHEBI:76971
name: Escherichia coli metabolite
namespace: chebi_ontology
def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." []
subset: 3_STAR
synonym: "E.coli metabolite" RELATED [ChEBI]
synonym: "E.coli metabolites" RELATED [ChEBI]
synonym: "Escherichia coli metabolites" RELATED [ChEBI]
is_a: CHEBI:76969 ! bacterial metabolite

[Term]
id: CHEBI:77402
name: EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
namespace: chebi_ontology
def: "An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12)." []
subset: 3_STAR
synonym: "EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors" RELATED [ChEBI]
synonym: "EC 1.8.1.12 inhibitor" RELATED [ChEBI]
synonym: "EC 1.8.1.12 inhibitors" RELATED [ChEBI]
synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor" RELATED [ChEBI]
synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors" RELATED [ChEBI]
synonym: "NADPH2:trypanothione oxidoreductase inhibitor" RELATED [ChEBI]
synonym: "NADPH2:trypanothione oxidoreductase inhibitors" RELATED [ChEBI]
synonym: "NADPH:trypanothione oxidoreductase inhibitor" RELATED [ChEBI]
synonym: "NADPH:trypanothione oxidoreductase inhibitors" RELATED [ChEBI]
synonym: "trypanothione reductase inhibitor" RELATED [ChEBI]
synonym: "trypanothione reductase inhibitors" RELATED [ChEBI]
synonym: "trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor" RELATED [ChEBI]
synonym: "trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors" RELATED [ChEBI]
synonym: "trypanothione:NADP(+) oxidoreductase inhibitor" RELATED [ChEBI]
synonym: "trypanothione:NADP(+) oxidoreductase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Trypanothione-disulfide_reductase
is_a: CHEBI:76869 ! EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor

[Term]
id: CHEBI:77746
name: human metabolite
namespace: chebi_ontology
alt_id: CHEBI:75770
alt_id: CHEBI:77123
def: "Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens)." []
subset: 3_STAR
synonym: "H. sapiens metabolite" RELATED [ChEBI]
synonym: "H. sapiens metabolites" RELATED [ChEBI]
synonym: "Homo sapiens metabolite" RELATED [ChEBI]
synonym: "Homo sapiens metabolites" RELATED [ChEBI]
is_a: CHEBI:75768 ! mammalian metabolite

[Term]
id: CHEBI:77941
name: EC 3.5.1.4 (amidase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." []
subset: 3_STAR
synonym: "acylamidase inhibitor" RELATED [ChEBI]
synonym: "acylamidase inhibitors" RELATED [ChEBI]
synonym: "acylamide amidohydrolase inhibitor" RELATED [ChEBI]
synonym: "acylamide amidohydrolase inhibitors" RELATED [ChEBI]
synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [ChEBI]
synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [ChEBI]
synonym: "amidase inhibitor" RELATED [ChEBI]
synonym: "amidase inhibitors" RELATED [ChEBI]
synonym: "amidohydrolase inhibitor" RELATED [ChEBI]
synonym: "amidohydrolase inhibitors" RELATED [ChEBI]
synonym: "deaminase inhibitor" RELATED [ChEBI]
synonym: "deaminase inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.4 inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.1.4 inhibitors" RELATED [ChEBI]
synonym: "fatty acylamidase inhibitor" RELATED [ChEBI]
synonym: "fatty acylamidase inhibitors" RELATED [ChEBI]
synonym: "N-acetylaminohydrolase inhibitor" RELATED [ChEBI]
synonym: "N-acetylaminohydrolase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Amidase
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor

[Term]
id: CHEBI:78017
name: food propellant
namespace: chebi_ontology
def: "A propellant that is used to expel foods from an aerosol container." []
subset: 3_STAR
synonym: "food propellants" RELATED [ChEBI]
is_a: CHEBI:64047 ! food additive
is_a: CHEBI:76414 ! propellant

[Term]
id: CHEBI:78295
name: food component
namespace: chebi_ontology
def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." []
subset: 3_STAR
synonym: "dietary component" RELATED [ChEBI]
synonym: "dietary components" RELATED [ChEBI]
synonym: "food components" RELATED [ChEBI]
is_a: CHEBI:52211 ! physiological role

[Term]
id: CHEBI:78298
name: environmental contaminant
namespace: chebi_ontology
def: "Any minor or unwanted substance introduced into the environment that can have undesired effects." []
subset: 3_STAR
synonym: "environmental contaminants" RELATED [ChEBI]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:78433
name: refrigerant
namespace: chebi_ontology
def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." []
subset: 3_STAR
synonym: "refrigerants" RELATED [ChEBI]
xref: Wikipedia:Refrigerant
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:78592
name: vesicant
namespace: chebi_ontology
def: "Any compound that causes severe skin, eye and mucosal pain and irritation." []
subset: 3_STAR
synonym: "blister agent" RELATED [ChEBI]
synonym: "blister agents" RELATED [ChEBI]
synonym: "vesicants" RELATED [ChEBI]
xref: PMID:16168310 {source="Europe PMC"}
xref: Wikipedia:Blister_agent
is_a: CHEBI:52208 ! biophysical role

[Term]
id: CHEBI:78608
name: alpha-amino acid zwitterion
namespace: chebi_ontology
alt_id: CHEBI:83409
def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." []
subset: 3_STAR
synonym: "an alpha-amino acid" RELATED [UniProt]
xref: MetaCyc:Alpha-Amino-Acids {source="SUBMITTER"}
is_a: CHEBI:35238 ! amino acid zwitterion
relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C([*])C([O-])=O" xsd:string

[Term]
id: CHEBI:78616
name: carbohydrates and carbohydrate derivatives
namespace: chebi_ontology
def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." []
subset: 3_STAR
synonym: "carbohydrates and derivatives" RELATED [ChEBI]
synonym: "carbohydrates and their derivatives" RELATED [ChEBI]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:78675
name: fundamental metabolite
namespace: chebi_ontology
def: "Any metabolite produced by all living cells." []
subset: 3_STAR
synonym: "essential metabolite" RELATED [ChEBI]
synonym: "essential metabolites" RELATED [ChEBI]
synonym: "fundamental metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:79387
name: trivalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of three." []
subset: 3_STAR
synonym: "trivalent inorganic anions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:79388
name: divalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of two." []
subset: 3_STAR
synonym: "divalent inorganic anions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:79389
name: monovalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of one." []
subset: 3_STAR
synonym: "monovalent inorganic anions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:83039
name: crustacean metabolite
namespace: chebi_ontology
def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." []
subset: 3_STAR
synonym: "crustacean metabolites" RELATED [ChEBI]
is_a: CHEBI:75767 ! animal metabolite

[Term]
id: CHEBI:83056
name: Daphnia magna metabolite
namespace: chebi_ontology
def: "A Daphnia metabolite produced by the species Daphnia magna." []
subset: 3_STAR
synonym: "Daphnia magna metabolites" RELATED [ChEBI]
is_a: CHEBI:83057 ! Daphnia metabolite

[Term]
id: CHEBI:83057
name: Daphnia metabolite
namespace: chebi_ontology
def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" []
subset: 3_STAR
synonym: "Daphnia metabolites" RELATED [ChEBI]
xref: Wikipedia:Daphnia
is_a: CHEBI:83039 ! crustacean metabolite

[Term]
id: CHEBI:83347
name: organosulfonic ester
namespace: chebi_ontology
def: "An ester resulting from the formal condensation of the hydroxy group of an alcohol, phenol, heteroarenol, or enol with an organosulfonic acid." []
subset: 3_STAR
synonym: "organosulfonate ester" RELATED [ChEBI]
synonym: "organosulfonate esters" RELATED [ChEBI]
synonym: "organosulfonic esters" RELATED [ChEBI]
is_a: CHEBI:33424 ! sulfur oxoacid derivative
is_a: CHEBI:35701 ! ester
relationship: has_functional_parent CHEBI:33551 ! organosulfonic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O3SR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "80.06300" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.95681" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]S(=O)(=O)O[*]" xsd:string

[Term]
id: CHEBI:83414
name: alkyl sulfate(1-)
namespace: chebi_ontology
def: "An organosulfate oxoanion obtained by deprotonation of the sulfo group of any alkyl sulfate; major species at pH 7.3." []
subset: 3_STAR
synonym: "alkyl sulfate anion" RELATED [ChEBI]
synonym: "an alkyl sulfate" RELATED [UniProt]
xref: MetaCyc:Organo-Sulfates {source="SUBMITTER"}
is_a: CHEBI:58958 ! organosulfate oxoanion
relationship: is_conjugate_base_of CHEBI:29281 ! alkyl sulfate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.064" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S(=O)(=O)O[*]" xsd:string

[Term]
id: CHEBI:83811
name: proteinogenic amino acid derivative
namespace: chebi_ontology
def: "Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom." []
subset: 3_STAR
synonym: "canonical amino acid derivative" RELATED [ChEBI]
synonym: "canonical amino acid derivatives" RELATED [ChEBI]
synonym: "canonical amino-acid derivative" RELATED [ChEBI]
synonym: "canonical amino-acid derivatives" RELATED [ChEBI]
synonym: "proteinogenic amino acid derivatives" RELATED [ChEBI]
synonym: "proteinogenic amino-acid derivative" RELATED [ChEBI]
synonym: "proteinogenic amino-acid derivatives" RELATED [ChEBI]
is_a: CHEBI:83821 ! amino acid derivative
relationship: has_functional_parent CHEBI:83813 ! proteinogenic amino acid

[Term]
id: CHEBI:83812
name: non-proteinogenic amino acid derivative
namespace: chebi_ontology
def: "Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom." []
subset: 3_STAR
synonym: "non-canonical amino acid derivative" RELATED [ChEBI]
synonym: "non-canonical amino-acid derivatives" RELATED [ChEBI]
synonym: "non-proteinogenic amino-acid derivatives" RELATED [ChEBI]
is_a: CHEBI:83821 ! amino acid derivative

[Term]
id: CHEBI:83813
name: proteinogenic amino acid
namespace: chebi_ontology
def: "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." []
subset: 3_STAR
synonym: "canonical amino acid" RELATED [ChEBI]
synonym: "canonical amino acids" RELATED [ChEBI]
synonym: "proteinogenic amino acids" RELATED [ChEBI]
xref: Wikipedia:Proteinogenic_amino_acid
is_a: CHEBI:33709 ! amino acid

[Term]
id: CHEBI:83820
name: non-proteinogenic amino acid
namespace: chebi_ontology
def: "Any amino-acid that is not naturally encoded in the genetic code of any organism." []
subset: 3_STAR
synonym: "non-canonical amino acid" RELATED [ChEBI]
synonym: "non-canonical amino acids" RELATED [ChEBI]
synonym: "non-canonical amino-acid" RELATED [ChEBI]
synonym: "non-canonical amino-acids" RELATED [ChEBI]
synonym: "non-coded amino acid" RELATED [ChEBI]
synonym: "non-coded amino acids" RELATED [ChEBI]
synonym: "non-coded amino-acid" RELATED [ChEBI]
synonym: "non-coded amino-acids" RELATED [ChEBI]
synonym: "non-proteinogenic amino acids" RELATED [ChEBI]
synonym: "non-proteinogenic amino-acid" RELATED [ChEBI]
synonym: "non-proteinogenic amino-acids" RELATED [ChEBI]
xref: Wikipedia:Non-proteinogenic_amino_acids
is_a: CHEBI:33709 ! amino acid

[Term]
id: CHEBI:83821
name: amino acid derivative
namespace: chebi_ontology
alt_id: CHEBI:25359
def: "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues." []
subset: 3_STAR
synonym: "amino acid derivatives" RELATED [ChEBI]
synonym: "modified amino acids" RELATED [ChEBI]
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:83822
name: non-proteinogenic L-alpha-amino acid
namespace: chebi_ontology
def: "Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
subset: 3_STAR
synonym: "non-proteinogenic L-alpha-amino acids" RELATED [ChEBI]
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid

[Term]
id: CHEBI:83925
name: non-proteinogenic alpha-amino acid
namespace: chebi_ontology
def: "Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
subset: 3_STAR
synonym: "non-proteinogenic alpha-amino acids" RELATED [ChEBI]
synonym: "non-proteinogenic alpha-amino-acid" RELATED [ChEBI]
synonym: "non-proteinogenic alpha-amino-acids" RELATED [ChEBI]
is_a: CHEBI:33704 ! alpha-amino acid
is_a: CHEBI:83820 ! non-proteinogenic amino acid

[Term]
id: CHEBI:83982
name: L-glutamic acid derivative
namespace: chebi_ontology
def: "A proteinogenic amino acid derivative resulting from reaction of L-glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of L-glutamic acid by a heteroatom." []
subset: 3_STAR
synonym: "L-glutamic acid derivatives" RELATED [ChEBI]
is_a: CHEBI:24315 ! glutamic acid derivative
is_a: CHEBI:83811 ! proteinogenic amino acid derivative
relationship: has_functional_parent CHEBI:16015 ! L-glutamic acid

[Term]
id: CHEBI:84087
name: human urinary metabolite
namespace: chebi_ontology
def: "Any metabolite (endogenous or exogenous) found in human urine samples." []
subset: 3_STAR
synonym: "human urinary metabolites" RELATED [ChEBI]
is_a: CHEBI:77746 ! human metabolite

[Term]
id: CHEBI:84143
name: D-phenylalanine derivative
namespace: chebi_ontology
def: "A non-proteinogenic amino acid derivative resulting from reaction of D-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of D-phenylalanine by a heteroatom." []
subset: 3_STAR
synonym: "D-phenylalanine derivatives" RELATED [ChEBI]
is_a: CHEBI:25985 ! phenylalanine derivative
is_a: CHEBI:83812 ! non-proteinogenic amino acid derivative
relationship: has_functional_parent CHEBI:16998 ! D-phenylalanine

[Term]
id: CHEBI:84144
name: L-phenylalanine derivative
namespace: chebi_ontology
def: "A proteinogenic amino acid derivative resulting from reaction of L-phenylalanine  at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine  by a heteroatom." []
subset: 3_STAR
synonym: "L-phenylalanine derivatives" RELATED [ChEBI]
is_a: CHEBI:25985 ! phenylalanine derivative
is_a: CHEBI:83811 ! proteinogenic amino acid derivative
relationship: has_functional_parent CHEBI:17295 ! L-phenylalanine

[Term]
id: CHEBI:84735
name: algal metabolite
namespace: chebi_ontology
def: "Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae." []
subset: 3_STAR
synonym: "algal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:85046
name: skin lightening agent
namespace: chebi_ontology
def: "Any cosmetic used to lighten the colour of skin by reducing the concentration of melanin." []
subset: 3_STAR
synonym: "melanogenesis inhibitor" RELATED [ChEBI]
synonym: "melanogenesis inhibitors" RELATED [ChEBI]
synonym: "skin bleaching agent" RELATED [ChEBI]
synonym: "skin bleaching agents" RELATED [ChEBI]
synonym: "skin depigmenting agent" RELATED [ChEBI]
synonym: "skin depigmenting agents" RELATED [ChEBI]
synonym: "skin lightening agents" RELATED [ChEBI]
synonym: "skin whitening agent" RELATED [ChEBI]
synonym: "skin whitening agents" RELATED [ChEBI]
xref: PMID:21265866 {source="Europe PMC"}
xref: PMID:22132817 {source="Europe PMC"}
xref: PMID:22314516 {source="Europe PMC"}
xref: PMID:23891889 {source="Europe PMC"}
xref: PMID:23974587 {source="Europe PMC"}
xref: PMID:25535470 {source="Europe PMC"}
xref: PMID:25574195 {source="Europe PMC"}
xref: PMID:25643794 {source="Europe PMC"}
xref: Wikipedia:Skin_whitening
is_a: CHEBI:64857 ! cosmetic

[Term]
id: CHEBI:85234
name: human blood serum metabolite
namespace: chebi_ontology
def: "Any metabolite (endogenous or exogenous) found in human blood serum samples." []
subset: 3_STAR
synonym: "human blood serum metabolites" RELATED [ChEBI]
is_a: CHEBI:77746 ! human metabolite

[Term]
id: CHEBI:8711
name: quinacrine
namespace: chebi_ontology
def: "A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9." []
subset: 3_STAR
synonym: "2-methoxy-6-chloro-9-diethylaminopentylaminoacridine" RELATED [ChemIDplus]
synonym: "3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine" RELATED [ChemIDplus]
synonym: "4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine" EXACT IUPAC_NAME [IUPAC]
synonym: "6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine" RELATED [ChemIDplus]
synonym: "Mepacrine" RELATED [KEGG_COMPOUND]
synonym: "mepacrine" RELATED [ChemIDplus]
synonym: "N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine" RELATED [ChemIDplus]
synonym: "Quinacrine" EXACT [KEGG_COMPOUND]
xref: Beilstein:497807 {source="Beilstein"}
xref: Beilstein:95500 {source="Beilstein"}
xref: CAS:83-89-6 {source="ChemIDplus"}
xref: CAS:83-89-6 {source="KEGG COMPOUND"}
xref: Drug_Central:2338 {source="DrugCentral"}
xref: DrugBank:DB01103
xref: HMDB:HMDB0015235
xref: KEGG:C07339
xref: KEGG:D08179
xref: LINCS:LSM-1577
xref: MetaCyc:ATABRINE
xref: PMID:11339632 {source="Europe PMC"}
xref: PMID:11908878 {source="Europe PMC"}
xref: PMID:19747949 {source="Europe PMC"}
xref: Reaxys:95500 {source="Reaxys"}
xref: Wikipedia:Quinacrine
is_a: CHEBI:22213 ! acridines
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:50996 ! tertiary amino compound
relationship: has_parent_hydride CHEBI:36420 ! acridine
relationship: RO:0000087 CHEBI:38068 ! has role antimalarial
relationship: RO:0000087 CHEBI:77402 ! has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H30ClN3O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GPKJTRJOBQGKQK-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "399.95700" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "399.20774" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12" xsd:string

[Term]
id: CHEBI:88184
name: metal allergen
namespace: chebi_ontology
def: "Any metal which causes the onset of an allergic reaction." []
subset: 3_STAR
synonym: "allergenic metal" RELATED [ChEBI]
synonym: "allergenic metals" RELATED [ChEBI]
synonym: "metal allergens" RELATED [ChEBI]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33521 ! metal atom
relationship: RO:0000087 CHEBI:50904 ! has role allergen

[Term]
id: CHEBI:88188
name: drug allergen
namespace: chebi_ontology
def: "Any drug which causes the onset of an allergic reaction." []
subset: 3_STAR
synonym: "allergenic drug" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:50904 ! allergen

[Term]
id: CHEBI:90710
name: receptor modulator
namespace: chebi_ontology
alt_id: CHEBI:189678
def: "A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors." []
subset: 3_STAR
synonym: "receptor modulators" RELATED [ChEBI]
xref: Wikipedia:Receptor_modulator
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:91007
name: aromatic carboxylate
namespace: chebi_ontology
def: "A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3." []
subset: 3_STAR
synonym: "an aromatic carboxylate" RELATED [UniProt]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:33859 ! aromatic carboxylic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C([O-])=O" xsd:string

[Term]
id: FBcv:0000000
name: FlyBase CV
def: "FlyBase miscellaneous controlled vocabulary term." []

[Term]
id: FBcv:0000001
name: obsolete death certificate
namespace: pub_type
comment: This term was obsoleted because it was only ever used to annotate one publication: A copy of Calvin Bridges death certificate. This can still be found in the Drosophila offprint collection (FBrf0186653).
is_obsolete: true

[Term]
id: FBcv:0000002
name: abnormal thermotaxis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in thermotaxis (GO:0043052). 'thermotaxis' is defined as: 'The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.'" [FBC:DOS, GOC:cab1, WB_REF:cgc467]
synonym: "thermotaxis behavior defective" EXACT []
synonym: "thermotaxis behaviour defective" EXACT []
synonym: "thermotaxis defective" EXACT []
is_a: FBcv:0000683 ! abnormal temperature response

[Term]
id: FBcv:0000003
name: obsolete In transgenic Drosophila (intraspecific)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000004
name: obsolete Whole-organism transient assay (intraspecific)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000005
name: qualifier
def: "Term used to qualify a descriptor." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000000 ! FlyBase CV

[Term]
id: FBcv:0000006
name: male semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000375 ! semi-fertile
is_a: FBcv:0000376 ! male fertile

[Term]
id: FBcv:0000007
name: female semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000375 ! semi-fertile
is_a: FBcv:0000377 ! female fertile

[Term]
id: FBcv:0000008
name: modifier of variegation
namespace: phenotypic_class
def: "Genotype g1 is a modifier of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is significantly different from that caused by g2 alone." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "variegation" RELATED [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000009
name: obsolete temporal stage qualifier
namespace: temporal_qualifier
comment: This term has been obsoleted because all of its children terms have been obsoleted [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000010
name: obsolete monophasic
comment: This term has been obsoleted because there are new terms to replace it [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000011
name: obsolete relative temporal qualifier
namespace: temporal_qualifier
comment: This term has been obsoleted because all of its children terms have been obsoleted [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000012
name: obsolete absolute temporal qualifier
comment: This term has been obsoleted because both of its children terms have been obsoleted [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000013
name: descriptor
def: "Term that describes an allele, balancer, group or publication." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000000 ! FlyBase CV

[Term]
id: FBcv:0000014
name: structural qualifier
namespace: structural_qualifier
def: "Qualifier used to describe changes in number or location of an anatomical structure compared to wild type." [FBC:CP, FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000015
name: obsolete postage stamp
namespace: pub_type
comment: This term was obsoleted because it was little used.
is_obsolete: true

[Term]
id: FBcv:0000016
name: obsolete Baylor TE recombination mapping kit stock
comment: Consider - FBsv:0000605.
is_obsolete: true

[Term]
id: FBcv:0000017
name: obsolete penetrance qualifier
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000018
name: obsolete penetrance complete
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is complete when all the individuals of a given genotype exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000019
name: obsolete penetrance incomplete
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only some the individuals of a given genotype exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000020
name: obsolete penetrance percent
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only a percentage of the individuals of a given genotype exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
comment: This term should be modified by a % value. This is not currently possible in FlyBase curation.
is_obsolete: true

[Term]
id: FBcv:0000021
name: obsolete expressivity qualifier
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000022
name: obsolete expressivity complete
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is complete when an individual of a given genotype expresses the full phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000023
name: obsolete expressivity incomplete
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is incomplete when an individual of a given genotype expresses only partially the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000024
name: obsolete expressivity high
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'High expressivity' conveys that while expressivity is not complete, the phenotype expressed is approaching that of complete expressivity." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000025
name: obsolete expressivity low
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'Low expressivity' conveys that phenotype expressed is a much reduced version compared to complete expressivity." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000026
name: obsolete recessive visible allele recombination mapping stock
is_obsolete: true

[Term]
id: FBcv:0000027
name: obsolete dominant visible allele recombination mapping stock
is_obsolete: true

[Term]
id: FBcv:0000028
name: obsolete SNP recombination mapping stock
comment: Consider - FBsv:0001018.
is_obsolete: true

[Term]
id: FBcv:0000029
name: obsolete transposable element mutagenesis stock
is_obsolete: true

[Term]
id: FBcv:0000030
name: obsolete compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000031
name: obsolete anterior compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000032
name: obsolete compartment boundary
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000033
name: obsolete anterior/posterior compartment boundary
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000034
name: obsolete dorsal/ventral compartment boundary
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000035
name: obsolete dorsal compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000036
name: obsolete posterior compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000037
name: obsolete ventral compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000038
name: relative spatial qualifier
namespace: spatial_qualifier
def: "Qualifier that describes the spatial characteristics of a phenotype or expression pattern relative to the position of another entity." [FBC:CP]
subset: do_not_annotate
xref: PATO:0001631
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000039
name: anterior to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity." [PATO:0001632]
xref: PATO:0001632
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000040
name: distal to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located further from a more centrally located entity." [PATO:0001234]
xref: PATO:0001234
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000041
name: dorsal to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity." [PATO:0001233]
xref: PATO:0001233
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000042
name: obsolete deficiency kit stock
synonym: "deletion kit stock" RELATED []
is_obsolete: true

[Term]
id: FBcv:0000043
name: obsolete transposase source for transposable element mutagenesis
comment: Consider - FBsv:0001020.
is_obsolete: true

[Term]
id: FBcv:0000044
name: obsolete ammunition source for transposable element mutagenesis
comment: Consider - FBsv:0001022.
is_obsolete: true

[Term]
id: FBcv:0000045
name: posterior to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear of an organism relative to another entity." [PATO:0001633]
xref: PATO:0001633
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000046
name: precursor
namespace: temporal_qualifier
is_a: FBcv:0000176 ! temporal qualifier

[Term]
id: FBcv:0000047
name: proximal to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity." [PATO:0001195]
xref: PATO:0001195
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000048
name: surrounding
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously." [PATO:0001772]
xref: PATO:0001772
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000049
name: ventral to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the belly or lower surface of an organism relative to another entity." [FBC:CP]
xref: PATO:0001196
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000050
name: vicinity of
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located near in space in relation to another entity." [PATO:0002259]
synonym: "adjacent to" NARROW [PATO:0002259]
xref: PATO:0002259
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000051
name: segment boundary
namespace: spatial_qualifier
def: "Present in the area that separates segments." [FBC:MMC]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000052
name: spatial qualifier
namespace: spatial_qualifier
def: "Qualifier that describes the spatial characteristics of a phenotype or expression pattern." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000053
name: anterior
namespace: spatial_qualifier
def: "Restricted to anterior region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000054
name: apical
namespace: spatial_qualifier
def: "Restricted to apical region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000055
name: basal
namespace: spatial_qualifier
def: "Restricted to basal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000056
name: central
namespace: spatial_qualifier
def: "Restricted to central region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000057
name: obsolete contralateral
namespace: spatial_qualifier
comment: This term has been obsoleted because there is no way to combine it with an anatomy term to produce a meaningful statement [FBC:MMC]. mc160113.
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000058
name: distal
namespace: spatial_qualifier
def: "Restricted to distal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000059
name: dorsal
namespace: spatial_qualifier
def: "Restricted to dorsal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000060
name: dorso-lateral
namespace: spatial_qualifier
def: "Restricted to dorso-lateral region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000061
name: ectopic
namespace: structural_qualifier
def: "Anatomical structure is present in a location in which it would not be present in wild-type." [FBC:CP]
comment: An extra copy of an anatomical structure that is present in the same location as in wild-type should use 'increased number', rather than 'ectopic'.
xref: PATO:0000628
is_a: FBcv:0000014 ! structural qualifier

[Term]
id: FBcv:0000062
name: obsolete ipsilateral
namespace: spatial_qualifier
comment: This term has been obsoleted because there is no way to combine it with an anatomy term to produce a meaningful statement [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000063
name: lateral
namespace: spatial_qualifier
def: "Restricted to lateral region(s) of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000064
name: medial
namespace: spatial_qualifier
def: "Restricted to medial region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000065
name: posterior
namespace: spatial_qualifier
def: "Restricted to posterior region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000066
name: proximal
namespace: spatial_qualifier
def: "Restricted to proximal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000067
name: restricted
namespace: spatial_qualifier
def: "Restricted to unknown part(s) of a specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000068
name: increased number
namespace: structural_qualifier
def: "Present in the correct location but in larger numbers than in wild-type." [FBC:DOS]
synonym: "supernumerary" EXACT []
is_a: FBcv:0000014 ! structural qualifier

[Term]
id: FBcv:0000069
name: ubiquitous
namespace: spatial_qualifier
def: "Expressed everywhere at some specified stage." [FBC:DOS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000070
name: ventral
namespace: spatial_qualifier
def: "Restricted to ventral region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000071
name: ventro-lateral
namespace: spatial_qualifier
def: "Restricted to ventro-lateral region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000072
name: obsolete gene expression qualifier
is_obsolete: true

[Term]
id: FBcv:0000073
name: obsolete embryonic expression pattern
is_obsolete: true

[Term]
id: FBcv:0000074
name: egg length
namespace: spatial_qualifier
def: "Position in the egg or pre-gastrula embryo expressed as a percentage of egg length, where 0% corresponds to the posterior tip and 100% to the anterior tip." [FBC:DOS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000075
name: 0% egg length
namespace: spatial_qualifier
def: "At the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000076
name: 0-10% egg length
namespace: spatial_qualifier
def: "0-10% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000077
name: 0-100% egg length
namespace: spatial_qualifier
def: "The full length of the pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000078
name: 0-20% egg length
namespace: spatial_qualifier
def: "0-20% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000079
name: 0-30% egg length
namespace: spatial_qualifier
def: "0-30% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000080
name: 0-40% egg length
namespace: spatial_qualifier
def: "0-40% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000081
name: 0-50% egg length
namespace: spatial_qualifier
def: "0-50% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000082
name: 0-60% egg length
namespace: spatial_qualifier
def: "0-60% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000083
name: 0-70% egg length
namespace: spatial_qualifier
def: "0-70% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000084
name: 0-80% egg length
namespace: spatial_qualifier
def: "0-80% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000085
name: 0-90% egg length
namespace: spatial_qualifier
def: "0-90% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000086
name: 10% egg length
namespace: spatial_qualifier
def: "10% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000087
name: 10-100% egg length
namespace: spatial_qualifier
def: "10-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000088
name: 10-20% egg length
namespace: spatial_qualifier
def: "10-20% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000089
name: 10-30% egg length
namespace: spatial_qualifier
def: "10-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000090
name: 10-40% egg length
namespace: spatial_qualifier
def: "10-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000091
name: 10-50% egg length
namespace: spatial_qualifier
def: "10-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000092
name: 10-60% egg length
namespace: spatial_qualifier
def: "10-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000093
name: 10-70% egg length
namespace: spatial_qualifier
def: "10-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000094
name: 10-80% egg length
namespace: spatial_qualifier
def: "10-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000095
name: 10-90% egg length
namespace: spatial_qualifier
def: "10-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000096
name: 100% egg length
namespace: spatial_qualifier
def: "At the anterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000097
name: 20% egg length
namespace: spatial_qualifier
def: "20% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000098
name: 20-100% egg length
namespace: spatial_qualifier
def: "20-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000099
name: 20-30% egg length
namespace: spatial_qualifier
def: "20-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000100
name: 20-40% egg length
namespace: spatial_qualifier
def: "20-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000101
name: 20-50% egg length
namespace: spatial_qualifier
def: "20-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000102
name: 20-60% egg length
namespace: spatial_qualifier
def: "20-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000103
name: 20-70% egg length
namespace: spatial_qualifier
def: "20-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000104
name: 20-80% egg length
namespace: spatial_qualifier
def: "20-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000105
name: 20-90% egg length
namespace: spatial_qualifier
def: "20-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000106
name: 30% egg length
namespace: spatial_qualifier
def: "30% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000107
name: 30-100% egg length
namespace: spatial_qualifier
def: "30-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000108
name: 30-40% egg length
namespace: spatial_qualifier
def: "30-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000109
name: 30-50% egg length
namespace: spatial_qualifier
def: "30-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000110
name: 30-60% egg length
namespace: spatial_qualifier
def: "30-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000111
name: 30-70% egg length
namespace: spatial_qualifier
def: "30-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000112
name: 30-80% egg length
namespace: spatial_qualifier
def: "30-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000113
name: 30-90% egg length
namespace: spatial_qualifier
def: "30-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000114
name: 40% egg length
namespace: spatial_qualifier
def: "40% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000115
name: 40-100% egg length
namespace: spatial_qualifier
def: "40-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000116
name: 40-50% egg length
namespace: spatial_qualifier
def: "40-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000117
name: 40-60% egg length
namespace: spatial_qualifier
def: "40-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000118
name: 40-70% egg length
namespace: spatial_qualifier
def: "40-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000119
name: 40-80% egg length
namespace: spatial_qualifier
def: "40-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000120
name: 40-90% egg length
namespace: spatial_qualifier
def: "40-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000121
name: 50% egg length
namespace: spatial_qualifier
def: "50% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000122
name: 50-100% egg length
namespace: spatial_qualifier
def: "50-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000123
name: 50-60% egg length
namespace: spatial_qualifier
def: "50-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000124
name: 50-70% egg length
namespace: spatial_qualifier
def: "50-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000125
name: 50-80% egg length
namespace: spatial_qualifier
def: "50-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000126
name: 50-90% egg length
namespace: spatial_qualifier
def: "50-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000127
name: 60% egg length
namespace: spatial_qualifier
def: "60% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000128
name: 60-100% egg length
namespace: spatial_qualifier
def: "60-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000129
name: 60-80% egg length
namespace: spatial_qualifier
def: "60-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000130
name: 60-90% egg length
namespace: spatial_qualifier
def: "60-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000131
name: 70% egg length
namespace: spatial_qualifier
def: "70% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000132
name: 70-100% egg length
namespace: spatial_qualifier
def: "70-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000133
name: 70-80% egg length
namespace: spatial_qualifier
def: "70-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000134
name: 70-90% egg length
namespace: spatial_qualifier
def: "70-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000135
name: 80% egg length
namespace: spatial_qualifier
def: "80% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000136
name: 80-90% egg length
namespace: spatial_qualifier
def: "80-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000137
name: 90% egg length
namespace: spatial_qualifier
def: "90% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000139
name: 90-100% egg length
namespace: spatial_qualifier
alt_id: FBcv:0000138
def: "90-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
synonym: "90-100% egg length" RELATED []
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000140
name: FlyBase analysis
namespace: pub_type
def: "A record of an analysis carried out by FlyBase that has not been formally published." [FBC:SM]
is_a: FBcv:0000233 ! unpublished

[Term]
id: FBcv:0000141
name: gradient
namespace: spatial_qualifier
def: "Expression pattern which varies in intensity following a gradient in a specific axis." [FBC:MMC]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000142
name: anterior posterior gradient
namespace: spatial_qualifier
def: "Expression pattern which varies in intensity following a gradient in the anterior-posterior axis." [FBC:MMC]
is_a: FBcv:0000141 ! gradient

[Term]
id: FBcv:0000143
name: dorsal ventral gradient
namespace: spatial_qualifier
def: "Expression pattern which varies in intensity following a gradient in the dorsal-ventral axis." [FBC:MMC]
is_a: FBcv:0000141 ! gradient

[Term]
id: FBcv:0000144
name: obsolete maternal pattern
is_obsolete: true

[Term]
id: FBcv:0000145
name: striped
namespace: spatial_qualifier
def: "Restricted to stripes in some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000146
name: I-CreI
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of a 19-24 bp palindromic DNA site by the I-CreI endonuclease." [UniProt:P05725]
synonym: "change induced by I-CreI endonuclease cleavage" EXACT []
is_a: FBcv:0003007 ! site specific cleavage

[Term]
id: FBcv:0000147
name: even pair rule expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in even, but not odd numbered segment of the blastoderm." [FBC:DOS]
is_a: FBcv:0000322 ! pair rule expression pattern

[Term]
id: FBcv:0000148
name: odd pair rule expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in odd, but not even numbered segments of the blastoderm." [FBC:DOS]
is_a: FBcv:0000322 ! pair rule expression pattern

[Term]
id: FBcv:0000149
name: species list
namespace: pub_type
def: "A list of species found in a specified area." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000150
name: segmentally repeated
namespace: spatial_qualifier
def: "Restricted to a segmentally repeated pattern with some specified type." [FBC:DOS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000151
name: obsolete archive
namespace: pub_type
comment: This term was obsoleted because there because there were no instances of its use to classify any artefact in FlyBase.
is_obsolete: true

[Term]
id: FBcv:0000152
name: obsolete balancer stock
def: "A stock with one or more chromosomes (balancers) that are used primarily for their ability to preserve a stock genotype without selection." [FBC:KM]
comment: Consider - FBsv:0001001.
is_obsolete: true

[Term]
id: FBcv:0000153
name: cell autonomous
namespace: genotype_to_phenotype_relation
def: "A phenotypic effect which is expressed in and limited to cells of the mutant genetic constitution under investigation is said to be cell autonomous." [FlyBase:FBrf0002379]
is_a: FBcv:0000797 ! cell autonomy qualifier

[Term]
id: FBcv:0000154
name: cell non-autonomous
namespace: genotype_to_phenotype_relation
def: "A phenotypic effect which is not expressed in/limited to cells of the mutant genetic constitution under investigation is said to be cell non-autonomous." [FlyBase:FBrf0002379]
is_a: FBcv:0000797 ! cell autonomy qualifier

[Term]
id: FBcv:0000155
name: single balancer
def: "Chromosome that carries inversions and visible mutations, and which can be used to identify the genotype of an individual." [FlyBase:FBrf0089469, FlyBase:FBrf0202435]
is_a: FBcv:0000687 ! balancer descriptor

[Term]
id: FBcv:0000156
name: obsolete pair of homologous balancers
is_obsolete: true

[Term]
id: FBcv:0000157
name: obsolete recessive lethal balancer
is_obsolete: true

[Term]
id: FBcv:0000158
name: obsolete balancer for chromosome 1
comment: Consider - FBsv:0001006.
is_obsolete: true

[Term]
id: FBcv:0000159
name: obsolete balancer for chromosome 2
comment: Consider - FBsv:0001007.
is_obsolete: true

[Term]
id: FBcv:0000160
name: obsolete balancer for chromosome 3
comment: Consider - FBsv:0001008.
is_obsolete: true

[Term]
id: FBcv:0000161
name: maternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a maternal effect when the phenotype of an individual is a manifestation of the genotype of the mother, rather than the genotype of the individual." [ISBN:978-0-7167-3520-5]
is_a: FBcv:0000685 ! parental effect

[Term]
id: FBcv:0000162
name: non-rescuable maternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a non-rescuable maternal effect (strict maternal effect) when the introduction of a wild-type copy of the responsible mutation from the father has no ameliorating effect on the maternal effect mutant phenotype." [FlyBase:FBrf0049894]
is_a: FBcv:0000161 ! maternal effect

[Term]
id: FBcv:0000163
name: rescuable maternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a rescuable maternal effect when the introduction of a wild-type copy of the responsible mutation from the father ameliorates the maternal effect mutant phenotype." [FlyBase:FBrf0049894]
is_a: FBcv:0000161 ! maternal effect

[Term]
id: FBcv:0000164
name: paternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a paternal effect when the phenotype of an individual is a manifestation of the genotype of the father, rather than the genotype of the individual." [FlyBase:FBrf0102738]
is_a: FBcv:0000685 ! parental effect

[Term]
id: FBcv:0000165
name: obsolete pair of balancers for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000166
name: morphological qualifier
namespace: expression_qualifier
def: "Qualifier that describes an observed expression pattern." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000167
name: faint
namespace: expression_qualifier
def: "Weak expression." [FBC:MMC]
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000168
name: granular
namespace: expression_qualifier
def: "Expression pattern that resembles small grains or particles." [FBC:MMC]
xref: PATO:0001759
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000169
name: intense
namespace: expression_qualifier
def: "Strong expression." [FBC:MMC]
xref: PATO:0000049
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000170
name: punctate
namespace: expression_qualifier
def: "Expression pattern that resembles small dots." [FBC:MMC]
xref: PATO:0001512
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000171
name: uniform
namespace: expression_qualifier
def: "Expression pattern that is constant throughout the assayed anatomical entity." [FBC:MMC]
xref: PATO:0000438
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000172
name: variable
namespace: expression_qualifier
def: "Expression pattern that changes throughout the assayed anatomical entity." [FBC:MMC]
xref: PATO:0001227
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000173
name: obsolete pair of balancers for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000174
name: obsolete dominant male sterile balancer
comment: Consider - FBsv:0001012.
is_obsolete: true

[Term]
id: FBcv:0000175
name: obsolete dominant female sterile balancer
comment: Consider - FBsv:0001012.
is_obsolete: true

[Term]
id: FBcv:0000176
name: temporal qualifier
namespace: temporal_qualifier
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000177
name: obsolete dominant female sterile balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000178
name: obsolete early
namespace: temporal_qualifier
comment: This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000179
name: obsolete dominant female sterile balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000180
name: obsolete dominant male sterile balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000181
name: obsolete late
namespace: temporal_qualifier
comment: This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000182
name: obsolete mid
namespace: temporal_qualifier
comment: This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000183
name: obsolete n day
comment: This term has been obsoleted because there are new stage terms that can be used instead [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000184
name: obsolete n hr
comment: This term has been obsoleted because there are new stage terms that can be used instead [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000185
name: obsolete dominant male sterile balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000186
name: obsolete recessive lethal balancer for chromosome 1
is_obsolete: true

[Term]
id: FBcv:0000187
name: obsolete recessive lethal balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000188
name: publication descriptor
def: "Qualifier that describes the type of publication." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0000189
name: publication class
namespace: pub_type
def: "A publicly available document. It includes individual articles, such as research papers and reviews, and collections of articles, such as scientific journals." [FBC:DOS, FBC:SM]
subset: do_not_annotate
is_a: FBcv:0000188 ! publication descriptor

[Term]
id: FBcv:0000190
name: abstract
namespace: pub_type
def: "An individual abstract of a presentation at a meeting, congress, conference, symposium, colloquium, seminar, workshop, round table, or other professional gathering." [MeSH:D016416]
synonym: "Meeting Abstracts" EXACT [MeSH:D016416]
xref: MeSH:D016416
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000191
name: obsolete advertisement
namespace: pub_type
comment: This term was obsoleted because it only ever used to annotate a couple of publications.
is_obsolete: true

[Term]
id: FBcv:0000192
name: autobiography
namespace: pub_type
def: "A work consisting of a self-described account." [MeSH:D020493]
xref: MeSH:D020493
is_a: FBcv:0000194 ! biography

[Term]
id: FBcv:0000193
name: bibliographic list
namespace: pub_type
def: "A work consisting of a list of books, articles, documents, publications, and other items, usually on a single subject or related subjects." [MeSH:D016417]
synonym: "Bibliography" EXACT [MeSH:D016417]
xref: MeSH:D016417
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000194
name: biography
namespace: pub_type
def: "A work consisting of an account of the events, works, and achievements, personal and professional, during a person's life. This class includes articles on the activities and accomplishments of living persons as well as the presentation of an obituary." [MeSH:D019215]
xref: MeSH:D019215
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000195
name: book
namespace: pub_type
def: "A publication on a single subject or related subjects that is complete in itself, whether constructed of chapters, sections, or parts, and that is not issued on a regular, ongoing basis. Every chapter is written by the same author or authors of the publication." [FBC:SM]
comment: For books (in the common sense of the term) that have different authors for each chapter, please use 'edited book'.
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000196
name: obsolete booklet
namespace: pub_type
comment: This term was obsoleted because it was little used in curation. The formerly associated publications have mainly been annotated with other, more appropriate publication classes.
is_obsolete: true

[Term]
id: FBcv:0000197
name: book review
namespace: pub_type
def: "A work consisting of a critical analysis of one or more books or other monographic works." [MeSH:D022921]
synonym: "Book Reviews" EXACT [MeSH:D022921]
xref: MeSH:D022921
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000198
name: obsolete computer file
namespace: pub_type
synonym: "CD-ROM" RELATED []
is_obsolete: true

[Term]
id: FBcv:0000199
name: conference report
namespace: pub_type
def: "The published records of the papers delivered at or issued on the occasion of individual congresses, symposia, and meetings; abstracts of papers delivered at such congresses; reports of the officers and delegates of such congresses; combinations of the foregoing; or proceedings of the conference of a society if they are not limited to matters of internal organization." [MeSH:D016423]
comment: The definition is taken straight from the MeSH term Congresses, which PubMed uses to annotate both meeting reports written by attendees and conference abstract books. This term should therefore be used to index both of these two rather different artefacts.
synonym: "conference proceedings" NARROW []
synonym: "Congresses" EXACT [MeSH:D016423]
synonym: "meeting report" NARROW []
xref: MeSH:D016423
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000200
name: obsolete demonstration
namespace: pub_type
comment: This term was obsoleted because it was little used. All publications associated with it have been re-annotated with other publication classes.
is_obsolete: true

[Term]
id: FBcv:0000201
name: DNA/RNA sequence record
namespace: pub_type
def: "A record of a DNA or RNA sequence in some standard format, such as GenBank or EMBL or DDBJ." [FBC:DOS, FBC:SM]
is_a: FBcv:0000789 ! sequence record

[Term]
id: FBcv:0000202
name: protein sequence record
namespace: pub_type
def: "A record of a protein sequence in some standard format, such as UniProtKB." [FBC:SM]
is_a: FBcv:0000789 ! sequence record

[Term]
id: FBcv:0000203
name: erratum
namespace: pub_type
def: "A work consisting of an acknowledgement of an error, issued by a publisher, editor, or author." [MeSH:D016425]
synonym: "correction" EXACT []
synonym: "Corrigendum" EXACT [MeSH:D016425]
synonym: "Published Erratum" EXACT [MeSH:D016425]
xref: MeSH:D016425
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000204
name: film
namespace: pub_type
def: "A film or video that is factual, documentary or instructional in character." [FBC:SM, MeSH:D019499, MeSH:D019514]
synonym: "video" NARROW []
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000205
name: interview
namespace: pub_type
def: "A work consisting of a conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer." [MeSH:D017203]
xref: MeSH:D017203
is_a: FBcv:0000194 ! biography

[Term]
id: FBcv:0000206
name: obsolete jigsaw puzzle
namespace: pub_type
comment: This term was obsoleted because it only ever used to annotate one, unarchived publication.
is_obsolete: true

[Term]
id: FBcv:0000207
name: letter
namespace: pub_type
def: "A work consisting of written or printed communication between individuals or between persons and representatives of corporate bodies. The correspondence may be personal or professional." [MeSH:D016422]
comment: In medical and other scientific publications the letter is usually from one or more authors to the editor of the journal or book publishing the item being commented upon or discussed.
xref: MeSH:D016422
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000208
name: obsolete microscope slides
namespace: pub_type
comment: This term was obsoleted because it had only been used once in FlyBase, and this was for an artefact that is not present in a FlyBase associated archive. The associated record in FlyBase CHADO has been obsoleted.
is_obsolete: true

[Term]
id: FBcv:0000209
name: news article
namespace: pub_type
def: "A work consisting of an announcement or statement of recent or current events of new data and matters of interest in the field of medicine or science, published in a scientific journal." [FBC:SM, MeSH:D016433]
xref: MeSH:D016433
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000210
name: note
namespace: pub_type
def: "A work consisting of a critical or explanatory note written to discuss, support, or dispute an article or other presentation previously published." [MeSH:D016420]
synonym: "Comment" EXACT [MeSH:D016420]
xref: MeSH:D016420
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000211
name: obituary
namespace: pub_type
def: "A published announcement of a death accompanied by a short biography of the deceased." [FBC:SM]
is_a: FBcv:0000194 ! biography

[Term]
id: FBcv:0000212
name: paper
namespace: pub_type
def: "An article reporting original research, published in a peer-reviewed journal." [FBC:SM]
comment: Note that this is a much more specific class than that referred to by MeSH Journal article (D016428).
synonym: "Journal article" BROAD [MeSH:D016428]
xref: MeSH:D016428
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000213
name: patent
namespace: pub_type
def: "A work consisting of documents granted by a government giving exclusive rights to an inventor or assignee to manufacture, use, or sell an invention for a certain number of years." [MeSH:D020490]
xref: MeSH:D020490
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000214
name: personal communication to FlyBase
namespace: pub_type
def: "A work that has not been formally published and that consists of observations or data submitted by a researcher or group of researchers directly to FlyBase." [FBC:DOS, FBC:SM]
is_a: FBcv:0000233 ! unpublished

[Term]
id: FBcv:0000215
name: poem
namespace: pub_type
def: "A literary or oral work expressing meaning via symbolism and following formal or informal patterns." [MeSH:D055821]
synonym: "poetry" EXACT [MeSH:D055821]
xref: MeSH:D055821
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000216
name: poster
namespace: pub_type
def: "A work consisting of a single or multi-sheet notice made to attract attention to events, activities, causes, goods, or services. It is for posting, usually in a public place and is chiefly pictorial. It is intended to make an immediate impression from a distance." [MeSH:D019519]
comment: The class does not encompass poster presentations at conferences and meetings.
xref: MeSH:D019519
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000217
name: press release
namespace: pub_type
def: "A written or recorded communication directed at members of the news media for the purpose of announcing something ostensibly newsworthy." [http://en.wikipedia.org/w/index.php?title=Press_release&oldid=482495713]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000218
name: obsolete recording
namespace: pub_type
comment: This term has been obsoleted because it was little used in curation and the artefacts annotated with it are not present in any FlyBase associated archive. Records annotated with this term have been obsoleted in the FlyBase CHADO database.
is_obsolete: true

[Term]
id: FBcv:0000219
name: retraction
namespace: pub_type
def: "A work consisting of a statement issued by one or more authors of an article or a book, withdrawing or disavowing acknowledgement of their participation in performing research or writing the results of their study." [MeSH:D016440]
synonym: "Retraction of Publication" EXACT [MeSH:D016440]
xref: MeSH:D016440
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000220
name: review
namespace: pub_type
def: "An article or book published after examination of published material on a subject." [MeSH:D016454]
comment: The reviews most often desired are reviews of the current literature, but a review of historical literature is also within the scope of this publication type.
xref: MeSH:D016454
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000221
name: obsolete slides
namespace: pub_type
comment: This term has been obsoleted because it was little used in curation and the artefacts annotated with it are not present in any FlyBase associated archive.
is_obsolete: true

[Term]
id: FBcv:0000222
name: spoof
namespace: pub_type
def: "A mildly satirical mockery or parody of a conventional publication type." [FBC:SM]
xref: MeSH:D020480
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000223
name: stock list
namespace: pub_type
def: "A list of Drosophila stocks kept by a specified stock center or research group." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000224
name: supplementary material
namespace: pub_type
def: "Supporting content or information, such as animation, datasets, multimedia files, video, movies, audio files, text files, or software, which is submitted for publication in an online journal or an online edition of a journal. This information may be referenced in the text of the article with a link to the supplementary data provided." [MeSH:D058537]
synonym: "additional files" EXACT []
synonym: "Electronic Supplementary Materials" EXACT [MeSH:D058537]
synonym: "supplementary information" EXACT []
synonym: "supporting information" EXACT []
xref: MeSH:D058537
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000225
name: obsolete T-shirt
namespace: pub_type
comment: This term was obsoleted because it had been used only once in ~20 years of curation.
is_obsolete: true

[Term]
id: FBcv:0000226
name: obsolete tactile diagram
namespace: pub_type
def: "A diagram that is designed to be touched, rather than looked at. These are generally made for use by blind or visually impaired people." [FBC:DOS]
is_obsolete: true

[Term]
id: FBcv:0000227
name: teaching note
namespace: pub_type
def: "An article describing exercises or practicals suitable for teaching." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000228
name: thesis
namespace: pub_type
def: "A work consisting of a formal presentation made usually to fulfill requirements for an academic degree." [MeSH:D019478]
synonym: "Academic Dissertations" EXACT [MeSH:D019478]
xref: MeSH:D019478
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000229
name: curated genome annotation
namespace: pub_type
def: "A systematic effort to annotate gene models on a sequenced Drosophila genome, such as those conducted for D. melanogaster at the Celera Jamboree. Annotations may be performed manually or automatically." [FBC:SM]
comment: Note that the name of this publication type will change to simply 'genome annotation', but this change has been delayed pending required work on the database.
synonym: "automatic genome annotation" RELATED []
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000230
name: obsolete automatic genome annotation
namespace: pub_type
comment: This term was obsoleted because it was hardly ever used. Please use FBcv:0000229 instead.
is_obsolete: true
replaced_by: FBcv:0000229

[Term]
id: FBcv:0000231
name: white paper
namespace: pub_type
def: "A work consisting of a set of statements, directions, or principles presenting current or future rules or policy." [FBC:SM, MeSH:D016431]
synonym: "Guideline" BROAD [MeSH:D016431]
xref: MeSH:D016431
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000232
name: obsolete recessive lethal balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000233
name: unpublished
namespace: pub_type
def: "A work that has not been formally published." [MeSH:D022902]
synonym: "privately distributed report" RELATED []
synonym: "Unpublished Works" EXACT [MeSH:D022902]
xref: MeSH:D022902
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000234
name: publication language
namespace: language
def: "Qualifier that describes the language of the publication." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000188 ! publication descriptor

[Term]
id: FBcv:0000235
name: Afrikaans
namespace: language
def: "Publication in the Afrikaans language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000236
name: Arabic
namespace: language
def: "Publication in the Arabic language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000237
name: Armenian
namespace: language
def: "Publication in the Armenian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000238
name: Belarussian
namespace: language
def: "Publication in the Belarussian language." [FBC:MMC]
synonym: "Belarusian" RELATED []
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000239
name: Bulgarian
namespace: language
def: "Publication in the Bulgarian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000240
name: Catalan
namespace: language
def: "Publication in the Catalan language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000241
name: Chinese
namespace: language
def: "Publication in the Chinese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000242
name: Cumbrian
namespace: language
def: "Publication in the Cumbrian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000243
name: Czech
namespace: language
def: "Publication in the Czech language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000244
name: Danish
namespace: language
def: "Publication in the Danish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000245
name: Dutch
namespace: language
def: "Publication in the Dutch language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000246
name: English
namespace: language
def: "Publication in the English language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000247
name: Estonian
namespace: language
def: "Publication in the Estonian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000248
name: Faroese
namespace: language
def: "Publication in the Faroese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000249
name: Farsi
namespace: language
def: "Publication in the Farsi language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000250
name: Finnish
namespace: language
def: "Publication in the Finnish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000251
name: Flemish
namespace: language
def: "Publication in the Flemish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000252
name: French
namespace: language
def: "Publication in the French language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000253
name: German
namespace: language
def: "Publication in the German language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000254
name: Greek
namespace: language
def: "Publication in the Greek language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000255
name: Hebrew
namespace: language
def: "Publication in the Hebrew language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000256
name: Hungarian
namespace: language
def: "Publication in the Hungarian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000257
name: Icelandic
namespace: language
def: "Publication in the Icelandic language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000258
name: Indonesian
namespace: language
def: "Publication in the Indonesian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000259
name: Italian
namespace: language
def: "Publication in the Italian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000260
name: Japanese
namespace: language
def: "Publication in the Japanese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000261
name: Jugoslavian
namespace: language
def: "Publication in the Jugoslavian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000262
name: Korean
namespace: language
def: "Publication in the Korean language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000263
name: Latin
namespace: language
def: "Publication in the Latin language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000264
name: Latvian
namespace: language
def: "Publication in the Latvian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000265
name: Lithuanian
namespace: language
def: "Publication in the Lithuanian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000266
name: Malay
namespace: language
def: "Publication in the Malay language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000267
name: Malayalam
namespace: language
def: "Publication in the Malayalam language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000268
name: Norwegian
namespace: language
def: "Publication in the Norwegian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000269
name: Polish
namespace: language
def: "Publication in the Polish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000270
name: Portuguese
namespace: language
def: "Publication in the Portuguese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000271
name: Serbo-Croat(Roman)
namespace: language
def: "Publication in the Serbo-Croat (Roman) language." [FBC:MMC]
is_a: FBcv:0000274 ! Serbo-Croat

[Term]
id: FBcv:0000272
name: Romanian
namespace: language
def: "Publication in the Roman language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000273
name: Russian
namespace: language
def: "Publication in the Russian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000274
name: Serbo-Croat
namespace: language
def: "Publication in the Serbo-Croat language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000275
name: Slovak
namespace: language
def: "Publication in the Slovak language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000276
name: Slovenian
namespace: language
def: "Publication in the Slovenian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000277
name: Spanish
namespace: language
def: "Publication in the Spanish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000278
name: Swedish
namespace: language
def: "Publication in the Swedish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000279
name: Turkish
namespace: language
def: "Publication in the Turkish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000280
name: Ukrainian
namespace: language
def: "Publication in the Ukrainian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000281
name: Yiddish
namespace: language
def: "Publication in the Yiddish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000282
name: mutant scorability rank
namespace: scorability
def: "Rank that describes the usefulness of mutants according to their phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000283
name: RK1
namespace: scorability
def: "The RK1 rank describes mutants that are easily scored." [FlyBase:FBrf0066905]
is_a: FBcv:0000282 ! mutant scorability rank

[Term]
id: FBcv:0000284
name: RK2
namespace: scorability
def: "The RK2 rank describes mutants that are usable but less convenient." [FlyBase:FBrf0066905]
is_a: FBcv:0000282 ! mutant scorability rank

[Term]
id: FBcv:0000285
name: RK3
namespace: scorability
def: "The RK3 rank describes mutants that are of limited usefulness." [FlyBase:FBrf0066905]
is_a: FBcv:0000282 ! mutant scorability rank

[Term]
id: FBcv:0000286
name: allele class
namespace: allele_class
def: "Term that describes the type of allele." [FBC:MMC]
subset: do_not_annotate
synonym: "allele morphy class" EXACT []
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000287
name: loss of function allele
namespace: allele_class
def: "An allele that either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FlyBase:FBrf0049147]
comment: Loss of function alleles are generally, but not exclusively, recessive. At haplo-insufficient loci (loci that require two copies for normal function), loss of function alleles can be dominant.
is_a: FBcv:0000286 ! allele class

[Term]
id: FBcv:0000288
name: amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function from the observation that addition of extra copies in the genome has no effect on the phenotype. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000688 ! amorphic allele

[Term]
id: FBcv:0000289
name: hypomorphic allele - genetic evidence
namespace: allele_class
def: "Allele inferred to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity from the observation that extra copies in the genome decrease the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype than the allele in trans to a deletion of the gene (1 copy))." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000690 ! hypomorphic allele

[Term]
id: FBcv:0000290
name: gain of function allele
namespace: allele_class
def: "An allele that either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FlyBase:FBrf0049147]
comment: Gain of function alleles are generally dominant. But not all dominant alleles are gain of function alleles.
is_a: FBcv:0000286 ! allele class

[Term]
id: FBcv:0000291
name: neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that is inferred to make a gene product with a novel function or expression pattern compared to wild-type based on the evidence that the phenotype is unaffected by extra or fewer doses of the wild-type gene." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000697 ! neomorphic allele

[Term]
id: FBcv:0000292
name: antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele that is inferred to make a gene product that is antagonistic to the wild-type gene product from the observations that extra copies of the wild-type allele reduce the expressivity and/or penetrance of the phenotype. So, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. This test is similar to that used for hypomorphic alleles. An antimorph can be distinguished from a dominant hypermorph as only the former can be reverted to wild-type by deletion of the mutant allele." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000695 ! antimorphic allele

[Term]
id: FBcv:0000293
name: hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type from the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that homozygotes (2 copies) have a stronger phenotype than transheterozygotes to a deletion of the gene (1 copy)." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000696 ! hypermorphic allele

[Term]
id: FBcv:0000294
name: wild-type allele
namespace: allele_class
def: "Allele that corresponds to the wild-type one." [FBC:MMC]
is_a: FBcv:0000286 ! allele class

[Term]
id: FBcv:0000295
name: wild-type generic
namespace: allele_class
def: "Wild-type allele that can be distinguished from others." [FBC:MMC]
is_a: FBcv:0000294 ! wild-type allele

[Term]
id: FBcv:0000296
name: isoallele
namespace: allele_class
def: "Wild-type allele that can only be distinguished from another one under special conditions." [FlyBase:FBrf0202435]
is_a: FBcv:0000294 ! wild-type allele

[Term]
id: FBcv:0000297
name: obsolete extracted wild-type chromosome 1
is_obsolete: true

[Term]
id: FBcv:0000298
name: recessive
namespace: dominance_qualifier
def: "A phenotypic attribute is described as recessive when it is manifest only in individuals homozygous or hemizygous for the allele that causes that phenotype." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000565 ! dominance relationship qualifier

[Term]
id: FBcv:0000299
name: dominant
namespace: dominance_qualifier
def: "A phenotypic attribute is described as dominant when it is manifest in individuals heterozygous for the allele that causes that phenotype." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000565 ! dominance relationship qualifier

[Term]
id: FBcv:0000300
name: codominant
namespace: dominance_qualifier
def: "A phenotypic attribute is described as codominant when it is manifest in individuals carrying the allele that causes that phenotype, irrespective of the homologous allele." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000299 ! dominant

[Term]
id: FBcv:0000301
name: semidominant
namespace: dominance_qualifier
def: "A phenotypic attribute is described as semidominant when individuals heterozygous for the allele show phenotypes part way between homozygotes for either allele." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000299 ! dominant

[Term]
id: FBcv:0000302
name: obsolete extracted wild-type chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000303
name: obsolete extracted wild-type chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000304
name: obsolete extracted wild-type chromosome 4
is_obsolete: true

[Term]
id: FBcv:0000305
name: obsolete extracted wild-type chromosome Y
is_obsolete: true

[Term]
id: FBcv:0000306
name: sex limited
namespace: sex_qualifier
def: "Expression is limited to one or other sex by virtue of the particular biology of that sex, rather than the sex-linkage of the genes underlying the attribute." [FlyBase:FBrf0075559]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000332 ! sex

[Term]
id: FBcv:0000307
name: male limited
namespace: sex_qualifier
def: "Expression is limited to males by virtue of the particular biology of males, rather than the sex-linkage of the gene(s) involved." [FlyBase:FBrf0075559]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000306 ! sex limited

[Term]
id: FBcv:0000308
name: female limited
namespace: sex_qualifier
def: "Expression is limited to females by virtue of the particular biology of females, rather than the sex-linkage of the gene(s) involved." [FlyBase:FBrf0075559]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000306 ! sex limited

[Term]
id: FBcv:0000309
name: conditional
namespace: environmental_qualifier
def: "Phenotype expressed only under specific environmental conditions that do not induce the same defect in wild-type animals." [FBC:DOS]
synonym: "conditional qualifier" RELATED []
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000310
name: temperature conditional
namespace: environmental_qualifier
def: "Phenotype only expressed in some subset of the temperature range within which wild-type animals are viable." [FBC:DOS]
is_a: FBcv:0000309 ! conditional

[Term]
id: FBcv:0000311
name: heat sensitive
namespace: environmental_qualifier
def: "Phenotype only expressed at high temperatures." [FBC:DOS]
synonym: "conditional - heat sensitive" EXACT []
synonym: "conditional ts" EXACT []
synonym: "hs" EXACT []
is_a: FBcv:0000310 ! temperature conditional

[Term]
id: FBcv:0000312
name: cold sensitive
namespace: environmental_qualifier
def: "Phenotype only expressed at low temperatures." [FBC:DOS]
synonym: "conditional - cold sensitive" EXACT []
synonym: "conditional cs" EXACT []
synonym: "cs" EXACT []
is_a: FBcv:0000310 ! temperature conditional

[Term]
id: FBcv:0000313
name: drug conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of some specific drug (CHEBI:23888) whose presence does not induce the same defect in wild-type animals." [FBC:DOS]
is_a: FBcv:0000704 ! chemical conditional

[Term]
id: FBcv:0000314
name: RU486 conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of RU486 (CHEBI:50692), also known as mifepristone." [FBC:DOS]
synonym: "conditional mifepristone" EXACT []
synonym: "conditional RU486" EXACT []
is_a: FBcv:0000313 ! drug conditional

[Term]
id: FBcv:0000315
name: tetracycline conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of tetracycline (CHEBI:27902)." [FBC:DOS]
synonym: "conditional tetracycline" EXACT []
is_a: FBcv:0000313 ! drug conditional

[Term]
id: FBcv:0000316
name: homeotic
namespace: phenotypic_class
def: "Phenotype that is the partial or full transformation of one or more segments (FBbt:00000003) or segmental appendages from one identity to another. For example, in antennapedia an antenna is partially or fully transformed into a leg." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000317
name: obsolete isogenic chromosome 1
is_obsolete: true

[Term]
id: FBcv:0000318
name: obsolete isogenic chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000319
name: gap expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression across a contiguous block of two or more segments of the blastoderm." [FBC:DOS]
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000320
name: terminal expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in the terminal regions of the embryo/larva: the acron, telson and adjacent segments." [FBC:DOS]
synonym: "terminal" RELATED []
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000321
name: obsolete isogenic chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000322
name: pair rule expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in alternate segments of the blastoderm." [FBC:DOS]
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000323
name: segment polarity expression pattern
namespace: embryonic_pattern_qualifier
def: "Qualifier that describes an expression pattern of a segment polarity gene. Expression is observed in a specific location in each segment." [FBC:MMC]
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000324
name: abnormal dorsal/ventral axis specification
namespace: phenotypic_class
def: "Phenotype that is any abnormality in dorsal/ventral axis specification (GO:0009950). 'dorsal/ventral axis specification' is defined as: 'The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.'" [FBC:DOS, GOC:dph, GOC:go_curators, GOC:tb]
synonym: "dorsal-ventral polarity" RELATED [FBC:DOS]
synonym: "dorsal/ventral axis specification defective" EXACT []
is_a: FBcv:0000686 ! abnormal axis specification

[Term]
id: FBcv:0000325
name: neurogenic phenotype
namespace: phenotypic_class
def: "A phenotype that is an expansion of the developing embryonic nervous system at the expense of developing ventral epidermis." [FlyBase:FBrf0040185]
comment: Typically this is caused by and expansion of the population of neuroblasts at the expense of prospective epidermis, both of which originate in the ventral ectoderm.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-09-13T02:42:10Z" xsd:dateTime

[Term]
id: FBcv:0000326
name: obsolete isogenic chromosome 4
is_obsolete: true

[Term]
id: FBcv:0000327
name: obsolete P-element transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000328
name: obsolete hobo transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000329
name: obsolete piggyBac transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000330
name: obsolete minos transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000331
name: obsolete polyphasic
namespace: temporal_qualifier
comment: This term has been obsoleted because there are new terms to replace it [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000332
name: sex
namespace: sex_qualifier
def: "Qualifier that relates the expression of a phenotype to the sex of the individual." [FBC:MMC]
subset: do_not_annotate
synonym: "sex qualifier" EXACT [FBC:DOS]
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000333
name: male
namespace: sex_qualifier
def: "Expressed in males." [FBC:DOS]
comment: This term has historically been used as a qualifier for expression and phenotype, but its use for phenotype has been deprecated. Its use does not imply expression exclusively in males.
is_a: FBcv:0000332 ! sex

[Term]
id: FBcv:0000334
name: female
namespace: sex_qualifier
def: "Expressed in females." [FBC:DOS]
comment: This term has historically been used as a qualifier for expression and phenotype, but its use for phenotype has been deprecated. Its use does not imply expression exclusively in females.
is_a: FBcv:0000332 ! sex

[Term]
id: FBcv:0000335
name: germline clone
namespace: clone_qualifier
def: "A clone of germline cells that share a genotype." [FBC:DOS]
synonym: "germ-line clone" EXACT []
is_a: FBcv:0000812 ! clone of cells

[Term]
id: FBcv:0000336
name: somatic clone
namespace: clone_qualifier
def: "A clone of somatic cells that share a genotype that is different from the genotype of the animal in which it resides and from which it is derived." [FBC:DOS]
is_a: FBcv:0000812 ! clone of cells

[Term]
id: FBcv:0000337
name: obsolete P-element ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000338
name: obsolete hobo ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000339
name: obsolete fully
namespace: extent
comment: DEPRECATION WARNING: This term has been obsoleted as 'fully' is assumed in the absence of use of 'partially'. mc151118
is_obsolete: true
consider: FBcv:0000811

[Term]
id: FBcv:0000340
name: partially
namespace: extent
def: "Incomplete penetrance or expressivity of a phenotype or incomplete suppression of a phenotype." [FBC:DOS]
comment: Note on usage: This qualifier should not be used in combination with lethal, viable, sterile or fertile. For these cases, terms of the form semi-X should be used instead.
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000341
name: obsolete good
namespace: intensity_qualifier
comment: This term has been obsoleted as it should be assumed a phenotype is good, unless it is said otherwise, by using other qualifiers. mc151118
is_obsolete: true
consider: FBcv:0000811

[Term]
id: FBcv:0000342
name: poor
namespace: intensity_qualifier
def: "Qualifier that describes a phenotype that has poor penetrance or expressivity." [FBC:MMC]
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000343
name: reduced
namespace: intensity_qualifier
def: "Qualifier that describes a phenotype that has reduced penetrance or expressivity when compared to wild-type." [FBC:MMC]
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000344
name: slow
namespace: intensity_qualifier
def: "Qualifier that describes an electrophoretic migration of a gene product that is slower than the wild-type." [FBC:MMC]
xref: PATO:0000304
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000345
name: fast
namespace: intensity_qualifier
def: "Qualifier that describes an electrophoretic migration of a gene product that is intermediate in speed compared to the wild-type." [FBC:MMC]
xref: PATO:0000303
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000346
name: intermediate
namespace: intensity_qualifier
def: "Qualifier that describes a phenotype that is intermediate in speed compared to the wild-type." [FBC:MMC]
comment: This qualifier can be used to describe an electrophoretic migration of a gene product that is intermediate in speed compared to the wild-type.
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000347
name: phenotypic class
namespace: phenotypic_class
subset: do_not_annotate
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000348
name: wild-type
namespace: phenotypic_class
def: "The canonical phenotype of a wild-type Drosophilid." [FBC:DOS]
is_a: FBcv:0000347 ! phenotypic class
disjoint_from: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000349
name: viable
namespace: phenotypic_class
def: "A phenotype that is survival to mature adulthood, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
comment: Note, this term should not be used with the qualifier 'partially'. Use semi-viable or semi-lethal instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000347 ! phenotypic class

[Term]
id: FBcv:0000350
name: partially lethal - majority live
namespace: phenotypic_class
def: "A phenotype of a population that is the death of some significant proportion of animals in that population, but less that half, prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
subset: lethal_phase
synonym: "semi-viable" EXACT []
is_a: FBcv:0000349 ! viable
is_a: FBcv:0002015 ! partially lethal

[Term]
id: FBcv:0000351
name: lethal
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM]
comment: Note on usage: lethal is appropriate in cases where escaper adults are very rare. The lethal phase prior to becoming a mature adult may be further specified using children terms which specify stage.
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0000352
name: partially lethal - majority die
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a majority of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM, FBC:NB]
comment: Stages during which there is significant death prior to mature adulthood can be indicated using one or more stage qualifiers.
subset: lethal_phase
synonym: "semi-lethal" EXACT []
is_a: FBcv:0002015 ! partially lethal

[Term]
id: FBcv:0000353
name: cell lethal
namespace: phenotypic_class
def: "A phenotype that is a failure of mutant cells to survive." [FBC:DOS]
comment: Typically, this phenotype is assayed in clones of cells.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000354
name: visible
namespace: phenotypic_class
def: "A post-embryonic, macroscopic, anatomical phenotype." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000355
name: abnormal eye color
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eye color compared to wild-type." [FBC:DOS]
synonym: "eye color defective" EXACT []
synonym: "eye colour defective" EXACT []
is_a: FBcv:0000354 ! visible

[Term]
id: FBcv:0000356
name: abnormal body color
namespace: phenotypic_class
def: "A phenotype that is any abnormality in body color compared to wild-type." [FBC:DOS]
synonym: "body color defective" EXACT []
synonym: "body colour defective" EXACT []
is_a: FBcv:0000354 ! visible

[Term]
id: FBcv:0000357
name: abnormal size
namespace: phenotypic_class
def: "A phenotype that is any abnormality in the size of the whole body or some body part compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "size defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000358
name: decreased body size
namespace: phenotypic_class
def: "Phenotype that is a decrease in body size compared to identically raised wild-type controls." [FBC:DOS]
synonym: "reduced body size" EXACT []
synonym: "small body" EXACT []
is_a: FBcv:0000665 ! abnormal body size
is_a: FBcv:0007508 ! decreased size

[Term]
id: FBcv:0000359
name: decreased cell number
namespace: phenotypic_class
def: "Phenotype that is a decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth - there may be fewer cells in an otherwise normal volume of tissue." [FBC:DOS]
synonym: "reduced cell number" EXACT []
is_a: FBcv:0000709 ! abnormal cell number

[Term]
id: FBcv:0000360
name: decreased cell size
namespace: phenotypic_class
def: "Phenotype that is a decrease in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth of a tissue - there may be more cells in an otherwise normal volume of tissue." [FBC:DOS]
comment: Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells.
synonym: "reduced cell size" EXACT []
is_a: FBcv:0000428 ! abnormal cell size

[Term]
id: FBcv:0000361
name: increased body size
namespace: phenotypic_class
def: "Phenotype that is an increase in body size compared to identically raised wild-type controls." [FBC:DOS]
synonym: "large body" EXACT []
is_a: FBcv:0000665 ! abnormal body size
is_a: FBcv:0007507 ! increased size

[Term]
id: FBcv:0000362
name: increased cell number
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type." [FBC:DOS]
comment: This phenotype is not necessarily accompanied by overgrowth of a tissue - there may be more cells in an otherwise normal volume of tissue. It is not necessarily due to an increase in cell growth -it may be the result of an increase in the division rate at normal growth rates. It may not even be due to an increase in the cell division rate - a reduced rate of cell death while the division rate is normal could also achieve it.
is_a: FBcv:0000709 ! abnormal cell number

[Term]
id: FBcv:0000363
name: increased cell size
namespace: phenotypic_class
def: "Phenotype that is an increase in the size of cells compared to wild-type." [FBC:DOS]
comment: May be due to an increase in the cell growth rate or to a reduced rate of cell division along with a normal rate of cell growth.
is_a: FBcv:0000428 ! abnormal cell size

[Term]
id: FBcv:0000364
name: sterile
namespace: phenotypic_class
def: "A phenotype that is the inability to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000365
name: semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000366
name: female sterile
namespace: phenotypic_class
def: "A phenotype that is the inability of females to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note: this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead.
is_a: FBcv:0000364 ! sterile

[Term]
id: FBcv:0000367
name: female semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000365 ! semi-sterile

[Term]
id: FBcv:0000368
name: female sterile germline-dependent
namespace: phenotypic_class
def: "A phenotype of female sterility due to defects in the female germline." [FBC:DOS]
synonym: "female sterile germ-line-dependent" EXACT []
is_a: FBcv:0000366 ! female sterile

[Term]
id: FBcv:0000369
name: female sterile soma-dependent
namespace: phenotypic_class
def: "A phenotype of female sterility due to defects in somatic cells of the ovary (FBbt:00006030), or of the products of these cells (such as eggshell)." [FBC:DOS]
is_a: FBcv:0000366 ! female sterile

[Term]
id: FBcv:0000370
name: male sterile
namespace: phenotypic_class
def: "A phenotype that is the inability of males to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note - this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead.
is_a: FBcv:0000364 ! sterile

[Term]
id: FBcv:0000371
name: male semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000365 ! semi-sterile

[Term]
id: FBcv:0000372
name: male sterile germline-dependent
namespace: phenotypic_class
def: "A phenotype of male sterility due to defects in the male germline." [FBC:DOS]
synonym: "male sterile germ-line-dependent" EXACT []
is_a: FBcv:0000370 ! male sterile

[Term]
id: FBcv:0000373
name: male sterile soma-dependent
namespace: phenotypic_class
def: "A phenotype of male sterility due to defects in somatic cells of the testis (FBbt:00006031) or of the products of these cells." [FBC:DOS]
is_a: FBcv:0000370 ! male sterile

[Term]
id: FBcv:0000374
name: fertile
namespace: phenotypic_class
def: "A phenotype that is the ability to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000347 ! phenotypic class

[Term]
id: FBcv:0000375
name: semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000374 ! fertile
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000376
name: male fertile
namespace: phenotypic_class
def: "A phenotype that is the ability of males to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note - this term should not be used with the qualifier 'partially' - use male semi-sterile or male semi-fertile instead.
is_a: FBcv:0000374 ! fertile

[Term]
id: FBcv:0000377
name: female fertile
namespace: phenotypic_class
def: "A phenotype that is the ability of females to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note - this term should not be used with the qualifier 'partially' - use female semi-sterile or female semi-fertile instead.
is_a: FBcv:0000374 ! fertile

[Term]
id: FBcv:0000378
name: grandchildless
namespace: phenotypic_class
def: "A phenotype in which all offspring are sterile. Typically, this is due to maternal effect sterility resulting from defects in pole cell development." [ISBN:978-0-87969-321-3]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000379
name: enhancer of variegation
namespace: phenotypic_class
def: "Genotype g1 is an enhancer of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is greater than that caused by g2 alone." [FBC:DOS]
comment: Typically, g2 is a chromosomal aberration or an insertion.
is_a: FBcv:0000008 ! modifier of variegation

[Term]
id: FBcv:0000380
name: non-enhancer of variegation
namespace: phenotypic_class
def: "Genotype g1 is a non-enhancer of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not greater than that caused by g2 alone." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000381
name: suppressor of variegation
namespace: phenotypic_class
def: "Genotype g1 is a suppressor of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is less than that caused by to g2 alone." [FBC:DOS]
comment: Typically, g2 is a chromosomal aberration or an insertion.
is_a: FBcv:0000008 ! modifier of variegation

[Term]
id: FBcv:0000382
name: non-suppressor of variegation
namespace: phenotypic_class
def: "Genotype g1 is a non-suppressor of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not less than that caused by g2 alone." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000383
name: auxotroph
namespace: phenotypic_class
def: "A phenotype that is the inability to synthesize some organic compound that can be synthesized by wild-type animals, and that is required for normal growth and/or development." [http://en.wikipedia.org/wiki/Auxotrophic]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000384
name: abnormal aging
namespace: phenotypic_class
def: "Phenotype that is any abnormality in aging." [GOC:PO_curators]
subset: fbcvsubset_mgiribbons
synonym: "aging defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000385
name: short lived
namespace: phenotypic_class
def: "Phenotype that is a shorter adult life-span than wild-type." [FBC:DOS]
subset: lethal_phase
synonym: "increased adult mortality" EXACT []
is_a: FBcv:0002004 ! increased mortality

[Term]
id: FBcv:0000386
name: long lived
namespace: phenotypic_class
def: "Phenotype that is a longer adult life-span than wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000387
name: abnormal behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in behavior (GO:0007610). 'behavior' is defined as: 'The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.'" [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
subset: fbcvsubset_mgiribbons
synonym: "behavior defective" EXACT []
synonym: "behavioral" RELATED []
synonym: "behaviour defective" EXACT []
synonym: "behavioural" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000388
name: abnormal gravitaxis
namespace: phenotypic_class
def: "Phenotype that is a change in the strong tendency, seen in wild-type Drosophila melanogaster, to climb - a behavior otherwise known as negative gravitaxis (GO:0048060 ; movement away from the source of gravity)." [FBC:DOS]
comment: Note, this term should not be used when flies have climbing defects purely as a consequence of locomotion defects, use 'locomotor behavior defective' instead.
subset: fbcvsubset_mgiribbons
synonym: "geotaxis behaviour defective" RELATED []
synonym: "gravitaxis behavior defective" RELATED []
synonym: "gravitaxis defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000389
name: paralytic
namespace: phenotypic_class
def: "Phenotype that is a disposition to paralysis under conditions that do not cause paralysis in a wild-type animal. Paralysis is defined as an inability to exhibit `multicellular organismal movement` (GO:0050879)" [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000390
name: decreased rate of movement
namespace: phenotypic_class
def: "A phenotype consisting of an decrease in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "hypoactive" EXACT []
synonym: "reduced rate of movement" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000391
name: bang sensitive
namespace: phenotypic_class
def: "A phenotype exhibited following mechanical shock and consisting of a brief period of intense, uncoordinated motor activity (legs and wings flailing, abdomen coiling) followed by a prolonged period of paralysis." [FlyBase:FBrf0022877]
synonym: "easily shocked" RELATED [FlyBase:FBrf0022877]
is_a: FBcv:0000389 ! paralytic

[Term]
id: FBcv:0000392
name: increased rate of movement
namespace: phenotypic_class
def: "A phenotype consisting of an increase in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "hyperactive" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000393
name: abnormal pain response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to pain (GO:0048265). 'response to pain' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.'" [FBC:DOS, GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]
synonym: "pain response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000394
name: abnormal circadian rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian rhythm (GO:0007623). 'circadian rhythm' is defined as: 'Any biological process in an organism that recurs with a regularity of approximately 24 hours.'" [FBC:DOS, GOC:bf, GOC:go_curators]
subset: fbcvsubset_mgiribbons
synonym: "circadian rhythm defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000395
name: abnormal locomotor rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in locomotor rhythm (GO:0045475). 'locomotor rhythm' is defined as: 'The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.'" [FBC:DOS, GOC:go_curators]
synonym: "locomotor rhythm defective" EXACT []
is_a: FBcv:0000414 ! abnormal locomotor behavior
is_a: FBcv:0000679 ! abnormal circadian behavior

[Term]
id: FBcv:0000396
name: abnormal eclosion rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eclosion rhythm (GO:0008062). 'eclosion rhythm' is defined as: 'The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.'" [FBC:DOS, PMID:11715043]
synonym: "eclosion rhythm defective" EXACT []
is_a: FBcv:0000670 ! abnormal eclosion
is_a: FBcv:0000679 ! abnormal circadian behavior

[Term]
id: FBcv:0000397
name: abnormal learning
namespace: phenotypic_class
def: "Phenotype that is any abnormality in learning (GO:0007612). 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.'" [FBC:DOS, ISBN:0582227089, ISBN:0721662544]
synonym: "learning defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000398
name: abnormal memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in memory (GO:0007613). 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).'" [FBC:DOS, GOC:curators, ISBN:0582227089]
synonym: "memory defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000399
name: abnormal courtship behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'" [FBC:DOS, GOC:ai, GOC:dph]
synonym: "courtship behavior defective" EXACT []
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0000400
name: abnormal mating
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mating (GO:0007618). 'mating' is defined as: 'The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.'" [FBC:DOS, GOC:jl, ISBN:0387520546]
subset: fbcvsubset_mgiribbons
synonym: "mating defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000401
name: abnormal mating rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian mating behavior (GO:0035648). 'circadian mating behavior' is defined as: 'The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.'" [FBC:DOS, GOC:bf, GOC:dos, PMID:11470898, PMID:17276917]
synonym: "mating rhythm defective" EXACT []
is_a: FBcv:0000679 ! abnormal circadian behavior
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0000402
name: abnormal song
namespace: phenotypic_class
def: "Phenotype that is any abnormality in male courtship behavior, veined wing generated song production (GO:0045433). This is defined as 'The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.'" [FBC:DOS, GOC:mtg_sensu, PMID:11092827]
synonym: "singing defective" EXACT [FBC:SM]
synonym: "song defective" EXACT []
synonym: "song production defective" EXACT [FBC:SM]
is_a: FBcv:0000399 ! abnormal courtship behavior

[Term]
id: FBcv:0000403
name: abnormal chemosensory behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'." [FBC:DOS, GOC:go_curators]
synonym: "abnormal chemosensitive behavior" EXACT []
synonym: "chemosensitive behavior defective" EXACT []
synonym: "chemosensitive behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000404
name: abnormal smell perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of smell (GO:0007608). 'sensory perception of smell' is defined as: 'The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.'" [FBC:DOS, GOC:ai]
synonym: "olfaction defective" EXACT []
synonym: "smell perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000405
name: abnormal taste perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of taste (GO:0050909). 'sensory perception of taste' is defined as: 'The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.'" [FBC:DOS, GOC:ai]
synonym: "gustation defective" EXACT []
synonym: "taste defective" EXACT []
synonym: "taste perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000406
name: abnormal tarsal response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in or absense of proboscis extension reflex in response to a sugar stimulus via taste sensilla on the tarsus." [FBC:DOS]
synonym: "tarsal response defective" EXACT []
is_a: FBcv:0000680 ! abnormal proboscis extension reflex

[Term]
id: FBcv:0000407
name: abnormal auditory perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of sound (GO:0007605). 'sensory perception of sound' is defined as: 'The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.'" [FBC:DOS, GOC:ai]
synonym: "auditory perception defective" EXACT []
synonym: "auditory system defective" RELATED []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000408
name: abnormal stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to stress (GO:0006950). 'response to stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).'" [FBC:DOS, GOC:mah]
subset: fbcvsubset_mgiribbons
synonym: "environmental stress response defective" NARROW []
synonym: "stress response defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000409
name: abnormal osmotic stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to osmotic stress (GO:0006970). 'response to osmotic stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.'" [FBC:DOS, GOC:jl]
synonym: "osmotic stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000410
name: abnormal heat stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to heat (GO:0009408). 'response to heat' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.'" [FBC:DOS, GOC:lr]
synonym: "heat stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
is_a: FBcv:0000683 ! abnormal temperature response

[Term]
id: FBcv:0000411
name: abnormal visual behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in visual behavior (GO:0007632). 'visual behavior' is defined as: 'The behavior of an organism in response to a visual stimulus.'" [FBC:DOS, GOC:jid, GOC:pr]
synonym: "visual behavior defective" EXACT []
synonym: "visual behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000412
name: abnormal optomotor response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in optomotor response: a motor response during flight or walking that serves to stabilize both image formation on the retina and locomotor course." [FBC:DOS]
synonym: "optomotor behaviour defective" EXACT []
synonym: "optomotor response defective" EXACT []
is_a: FBcv:0000411 ! abnormal visual behavior

[Term]
id: FBcv:0000413
name: abnormal phototaxis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.'" [FBC:DOS, GOC:jl, ISBN:0192800981]
subset: fbcvsubset_mgiribbons
synonym: "phototaxis behaviour defective" RELATED []
synonym: "phototaxis defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000414
name: abnormal locomotor behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'" [FBC:DOS, GOC:dph]
synonym: "locomotor behavior defective" EXACT []
synonym: "locomotor behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000415
name: abnormal jumping
namespace: phenotypic_class
def: "Phenotype that is a reduced ability to jump or a reduced jump response. This may be due to neurological or muscular defects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "jumping defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000416
name: uncoordinated
namespace: phenotypic_class
def: "Phenotype that is abnormal co-ordination of motor activity." [FBC:CP, FBC:DOS]
is_a: FBcv:0000414 ! abnormal locomotor behavior

[Term]
id: FBcv:0000417
name: abnormal flight
namespace: phenotypic_class
def: "Phenotype that is any abnormality in flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.'" [FBC:DOS, GOC:dph]
comment: This term is agnostic as to the causes of defects in flight. An animal's flight may be defective for mechanical, behavioral or sensory reasons.
subset: fbcvsubset_mgiribbons
synonym: "flight behaviour defective" NARROW []
synonym: "flight defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000418
name: flightless
namespace: phenotypic_class
def: "Phenotype that is the absence of flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.'" [FBC:DOS, GOC:dph]
comment: This term is agnostic as to the causes of flightlessness. An animal may be flightless for mechanical or behavioral reasons.
is_a: FBcv:0000417 ! abnormal flight

[Term]
id: FBcv:0000419
name: abnormal feeding behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in feeding behavior (GO:0007631). 'feeding behavior' is defined as: 'Behavior associated with the intake of food.'" [FBC:DOS, GOC:mah]
synonym: "feeding behavior defective" EXACT []
synonym: "feeding behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000420
name: abnormal grooming behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'" [FBC:DOS, GOC:jl, GOC:pr]
synonym: "grooming behavior defective" EXACT []
synonym: "grooming behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000421
name: abnormal touch response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in or loss of a stereotypical behavioral response to touch." [FlyBase:FBrf0073546]
comment: This phenotype is commonly assayed by scoring larval avoidance responses following stroking of the thoracic segments (see Kernan et al., 1994). On its own, this is not sufficient evidence for an abnormality in sensory perception of touch, as motor defects can also cause this phenotype.
synonym: "touch response defective" EXACT []
synonym: "touch sensitivity defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000422
name: photoperiod response variant
namespace: phenotypic_class
def: "Phenotype that is any abnormality in entrainment of circadian clock by photoperiod (GO:0043153), which is defined as: 'The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).'" [FBC:DOS, GOC:jl]
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000423
name: abnormal DNA repair
namespace: phenotypic_class
def: "Phenotype that is any abnormality in DNA repair (GO:0006281). 'DNA repair' is defined as: 'The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.'" [FBC:DOS, PMID:11563486]
synonym: "DNA repair defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000424
name: abnormal cell death
namespace: phenotypic_class
def: "Phenotype that is a change in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. This may be due to effects on the regulation of cell death (GO:0010941) or in cell death (GO:0008219) pathways themselves." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "apoptosis defective" NARROW []
synonym: "cell death defective" EXACT []
synonym: "pcd defective" NARROW []
synonym: "programmed cell death defective" NARROW []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000425
name: increased cell death
namespace: phenotypic_class
def: "Phenotype that is an increase in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "pcd increase" NARROW []
synonym: "programmed cell death increase" NARROW []
is_a: FBcv:0000424 ! abnormal cell death

[Term]
id: FBcv:0000426
name: decreased cell death
namespace: phenotypic_class
def: "Phenotype that is a decrease in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "pcd decrease" NARROW []
synonym: "programmed cell death decrease" NARROW []
synonym: "reduced cell death" EXACT []
is_a: FBcv:0000424 ! abnormal cell death

[Term]
id: FBcv:0000427
name: abnormal cell growth
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell growth (GO:0016049). 'cell growth' is defined as: 'The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.'" [FBC:DOS, GOC:ai]
comment: Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells.
subset: fbcvsubset_mgiribbons
synonym: "cell growth defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000428
name: abnormal cell size
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell size defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000429
name: abnormal cell shape
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the shape (PATO:0000052) of some cell compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell shape defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000430
name: abnormal cell polarity
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the asymmetric distribution of components within a cell. For example an epithelial cell is 'cell polarity defective' if it lacks the normal asymmetric distribution of proteins or cell components such as junctions or villi along its apical-basal axis." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell polarity defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000431
name: abnormal meiotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in meiotic cell cycle (GO:0051321). 'meiotic cell cycle' is defined as: 'Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.'" [FBC:DOS, GOC:ai]
synonym: "meiotic" RELATED []
synonym: "meiotic cell cycle defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle

[Term]
id: FBcv:0000432
name: abnormal mitotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mitotic cell cycle (GO:0000278). 'mitotic cell cycle' is defined as: 'Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.'" [FBC:DOS, GOC:mah, ISBN:0815316194, Reactome:69278]
synonym: "mitotic" RELATED []
synonym: "mitotic cell cycle defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle

[Term]
id: FBcv:0000433
name: abnormal cytokinesis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cytokinesis (GO:0000910). 'cytokinesis' is defined as: 'The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.'" [FBC:DOS, GOC:mtg_cell_cycle]
synonym: "cytokinesis defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle

[Term]
id: FBcv:0000434
name: abnormal neurophysiology
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the electrophysiological properties of some class of neurons, muscles or other anatomical structure of the nervous system. Examples of these phenotypes at the neuron class level include defects in spontaneous or evoked excitatory junction potential. Examples at a more gross anatomical level include abnormal retinal electrophysiology (e.g.- measured by an electroretinogram)." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "neurophysiology defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000435
name: abnormal neuroanatomy
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the anatomy of the nervous system (FBbt:00005093). 'nervous system' is defined as: 'All the nerve centers and nerve fibers in the central, visceral and peripheral nervous systems.'" [FBC:DOS, FlyBase:FBrf0166419]
subset: fbcvsubset_mgiribbons
synonym: "neuroanatomy defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000436
name: abnormal sex-determination
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sex determination (GO:0007530). 'sex determination' is defined as: 'Any process that establishes and transmits the specification of sexual status of an individual organism.'" [FBC:DOS, ISBN:0198506732]
subset: fbcvsubset_mgiribbons
synonym: "sex-determination defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000437
name: obsolete dosage compensation defective
namespace: phenotypic_class
comment: This term was obsoleted because it was felt that the evidence provided in papers is not enough to annotate with this term. mc161014
is_obsolete: true
consider: FBcv:0000436

[Term]
id: FBcv:0000438
name: electrophoretic variant
namespace: phenotypic_class
def: "Phenotype that is a difference in electrophoretic migration of a gene product compared to wild-type." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000439
name: chemical resistant
namespace: phenotypic_class
def: "Phenotype that is a decreased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000440
name: chemical sensitive
namespace: phenotypic_class
def: "Phenotype that is an increased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000441
name: radiation resistant
namespace: phenotypic_class
def: "Phenotype that is a decreased tendency for radiation exposure to cause toxic effects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000442
name: radiation sensitive
namespace: phenotypic_class
def: "Phenotype that is an increased tendency for radiation exposure to cause toxic effects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000443
name: Minute
namespace: phenotypic_class
def: "Dominant phenotype consisting of short slender bristles and delayed development. Homozygotes are cell lethal." [FlyBase:FBrf0066905]
comment: The phenotype may be a general result of mutations in essential components of the protein synthesis pathway, as a number of Minutes encode ribosomal proteins. In an animal that is heterozygous for a Minute mutation, cells with two wild-type alleles of the affected gene have a growth advantage. Many developmental studies take advantage of this fact to give somatic clones a growth advantage. The term 'Minute' should not be used to annotate the resulting phenotypes.
is_a: FBcv:0000450 ! abnormal developmental rate

[Term]
id: FBcv:0000444
name: hyperplasia
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of cells in a tissue or organ, usually associated with an increase in size, where the affected tissue or organ maintains its normal form." [ISBN:978-0-19-850673-7]
synonym: "hyperplastic" EXACT []
is_a: FBcv:0000362 ! increased cell number

[Term]
id: FBcv:0000445
name: obsolete tumorigenic
namespace: phenotypic_class
def: "Phenotype that is characterized by the formation of abnormal masses of tissue (tumors) as the result of neoplasia." [FBC:DOS]
comment: Obsoleted as this is the same phenotype as neoplasia.
is_obsolete: true
replaced_by: FBcv:0000723

[Term]
id: FBcv:0000446
name: melanotic mass phenotype
namespace: phenotypic_class
def: "Phenotype characterized by the formation of lumps of melanotic tissue inside the body in the absence of foreign bodies." [FlyBase:FBrf0094387, FlyBase:FBrf0194475]
comment: Melanotic capsules are formed around foreign bodies in wild-type animals as part of the immune response, for example as a protection against parasitoid wasps. Some, but not all melanotic mass phenotypes involve ectopic activation of this immune response. While melanotic masses are commonly referred to as melanotic tumors in the historical literature, this is a misnomer as they are rarely neoplastic.
synonym: "melanotic 'tumor'" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000447
name: melanotic necrosis
namespace: phenotypic_class
def: "Phenotype characterized by closely associated necrosis and melanization." [FlyBase:FBrf0155704]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000448
name: abnormal immune response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in immune response (GO:0006955). 'immune response' is defined as: 'Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.'" [FBC:DOS, GO_REF:0000022, GOC:add]
subset: fbcvsubset_mgiribbons
synonym: "immune response defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000449
name: abnormal planar polarity
namespace: phenotypic_class
def: "Phenotype that is any abnormality in establishment of planar polarity (GO:0001736). 'establishment of planar polarity' is defined as: 'Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.'" [GOC:dph]
comment: For apical-basal polarity phenotypes of epithelia, the appropriate term is 'cell polarity defective'.
subset: fbcvsubset_mgiribbons
synonym: "planar polarity defective" EXACT []
synonym: "tissue polarity defective" BROAD []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000450
name: abnormal developmental rate
namespace: phenotypic_class
def: "Phenotype that is a change in any kind of rate (e.g. speed, frequency) of any developmental process (GO:0032502) taking place prior to mature adulthood (defined as adult stage A3), compared to wild-type. Note, developmental processes include stages in development of the whole animal (e.g. larval development) as well as specific sub-processes, such as dorsal closure." [FBC:DOS]
comment: A more complete formalization would require a clause specifying stage. It might be possible to do this in OWL using the same system as we are using for lethal phase.
subset: fbcvsubset_mgiribbons
synonym: "developmental rate defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000451
name: abnormal wound healing
namespace: phenotypic_class
def: "Phenotype that is any abnormality in wound healing (GO:0042060). 'wound healing' is defined as: 'The series of events that restore integrity to a damaged tissue, following an injury.'" [GOC:bf, PMID:15269788]
synonym: "wound healing defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000452
name: origin of mutation
namespace: origin_of_mutation
def: "Describes the origin of the mutation that causes a phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000453
name: obsolete piggyBac ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000454
name: obsolete synthetic
namespace: origin_of_mutation
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000455
name: in vitro construct
namespace: origin_of_mutation
def: "DNA change introduced by using an in vitro construct. The sequence of the in vitro construct determines the type of change." [FBC:MMC]
synonym: "change induced by in vitro construct" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000456
name: in vitro construct - regulatory fusion
namespace: origin_of_mutation
def: "Sequence change introduced by using an in vitro construct that contains a fusion of the regulatory region of one gene on to the coding region of another. Examples in FlyBase include heat shock constructs, FRT flip out constructs and reporter genes." [FBC:DOS]
comment: Notes on usage: Use this, rather than 'in vitro construct - deletion', for families of promoter deletions. Thus, a family of deletions of eve promoters driving Ecol\\\\lacZ will have regulatory fusion, but not deletion, as their mutagen.
synonym: "change induced by an in vitro construct - regulatory fusion" EXACT []
synonym: "in vitro construct | regulatory fusion" RELATED []
is_a: FBcv:0000455 ! in vitro construct

[Term]
id: FBcv:0000457
name: in vitro construct - coding region fusion
namespace: origin_of_mutation
def: "Sequence change introduced by using an in vitro construct that contains a in-frame fusion of the open reading frames from two or more genes. In FlyBase, the resulting genes may be classified as fusion genes or tagged genes." [FBC:DOS]
synonym: "change induced by an in vitro construct - coding region fusion" EXACT []
synonym: "in vitro construct | coding region fusion" RELATED []
is_a: FBcv:0000455 ! in vitro construct

[Term]
id: FBcv:0000458
name: in vitro construct - site directed mutagenesis
namespace: origin_of_mutation
def: "Mutation induced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene." [FBC:DOS]
synonym: "in vitro construct | site directed mutagenesis" RELATED []
synonym: "mutation induced by an in vitro construct - site directed mutagenesis" EXACT []
is_a: FBcv:0000455 ! in vitro construct

[Term]
id: FBcv:0000459
name: in vitro construct - deletion
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct generated by internal deletion of some genomic sequence or cDNA." [FBC:DOS]
synonym: "change induced by an in vitro construct - deletion" EXACT []
synonym: "in vitro construct | deletion" RELATED []
is_a: FBcv:0000455 ! in vitro construct

[Term]
id: FBcv:0000460
name: in vitro construct - genomic fragment
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct containing a genomic fragment that partially or fully rescues loss of function mutations or deletions of the gene whose sequence it carries." [FBC:DOS]
comment: Notes on usage: 1. This term is applicable whether or not rescue using the construct is complete. 2. When a smaller rescue fragment is derived from a larger, by deletion of one or both ends, the mutagen shall be 'in vitro construct | deletion', with the larger being stated as the progenitor allele.
synonym: "change induced by an in vitro construct - genomic fragment" EXACT []
synonym: "in vitro construct | genomic fragment" RELATED []
is_a: FBcv:0000455 ! in vitro construct

[Term]
id: FBcv:0000461
name: in vitro construct - minigene
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct that contains the wild-type open reading frame of a gene (without introns), the expression of which is controlled by a wild-type promoter of the same gene. Such constructs are often generated by fusing a cDNA to a genomic region containing promoter sequences, or more rarely by deletion of introns and other non-essential sequences from a genomic region, leaving a wild type coding region and promoter intact." [FBC:DOS]
synonym: "change induced by an in vitro construct - minigene" EXACT []
synonym: "in vitro construct | minigene" RELATED []
is_a: FBcv:0000455 ! in vitro construct

[Term]
id: FBcv:0000462
name: in vitro construct - amino acid replacement
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene resulting in a change to the change to the amino acids sequence encodes.." [FBC:DOS]
synonym: "change induced by an in vitro construct - amino acid replacement" EXACT []
synonym: "in vitro construct | amino acid replacement" RELATED []
is_a: FBcv:0000458 ! in vitro construct - site directed mutagenesis

[Term]
id: FBcv:0000463
name: in vitro construct - RNAi
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct designed to generate dsRNA for RNA interference (RNAi) experiments." [FBC:DOS]
synonym: "change induced by an in vitro construct - RNAi" EXACT []
synonym: "in vitro construct | RNAi" RELATED []
is_a: FBcv:0000455 ! in vitro construct

[Term]
id: FBcv:0000464
name: obsolete in vitro construct - other
namespace: origin_of_mutation
synonym: "in vitro construct | other" EXACT []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000465
name: natural population
namespace: origin_of_mutation
def: "Mutation found in a natural population." [FBC:MMC]
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000466
name: temperature
namespace: origin_of_mutation
def: "Mutation caused by exposure to a temperature that is higher or lower than 25 degrees Celsius." [FBC:MMC]
synonym: "environmental treatment" RELATED []
synonym: "mutation induced by temperature treatment" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000467
name: cold
namespace: origin_of_mutation
def: "Mutation induced by exposure to temperature that is lower than 25 degrees Celsius." [FBC:MMC]
synonym: "cold-treatment" RELATED []
synonym: "mutation induced by cold treatment" EXACT []
is_a: FBcv:0000466 ! temperature

[Term]
id: FBcv:0000468
name: heat
namespace: origin_of_mutation
def: "Mutation induced by exposure to a temperature that is higher than 25 degrees Celsius." [FBC:MMC]
synonym: "heat-treatment" RELATED []
synonym: "mutation induced by heat treatment" EXACT []
is_a: FBcv:0000466 ! temperature

[Term]
id: FBcv:0000469
name: spontaneous
namespace: origin_of_mutation
def: "Mutation caused by a spontaneous event." [FBC:MMC]
synonym: "mutation induced by spontaneous event" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000470
name: recombination
namespace: origin_of_mutation
def: "Sequence change induced by the genetic exchange that takes place between DNA sequences." [FBC:MC, ISBN:978-0-8153-3218-3]
synonym: "change induced by recombination" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000471
name: gene conversion
namespace: origin_of_mutation
def: "Sequence change caused by a DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor (GO:0035822)." [PMID:17846636]
comment: Strictly, gene conversion (GO:0035822) defines only the endogenous process, not its use for engineered gene targeting.
synonym: "change induced by gene conversion" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000472
name: intralocus exchange
namespace: origin_of_mutation
def: "Mutation caused by a recombination event that causes the unequal exchange of small intralocus regions, usually leading to the formation of duplication and deficiency products." [FBC:MC, FlyBase:FBrf0014117, FlyBase:FBrf0202435]
synonym: "mutation induced by intralocus exchange" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000473
name: unequal recombination
namespace: origin_of_mutation
def: "Sequence change caused by a recombination event that causes an unequal exchange of genetic material between homologous or non-homologous regions." [FlyBase:FBrf0202435]
synonym: "change induced by unequal recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000474
name: mitotic recombination
namespace: origin_of_mutation
def: "Sequence change caused by the exchange of genetic material during mitosis that occurs at crossing over, and more frequently between homologous chromosomes." [FlyBase:FBrf0202435]
synonym: "change induced by mitotic recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000475
name: magnification
namespace: origin_of_mutation
def: "Sequence change caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and an increase in the number of functional copies. It causes a reversion from mutant to wild-type phenotype." [FlyBase:FBrf0202435, FlyBase:FBrf0218934]
synonym: "mutation induced by magnification" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000476
name: detachment
namespace: origin_of_mutation
def: "Mutation that is caused by a recombination event that causes the breakdown of compound chromosome arms resulting in duplications or deletions in proximal regions." [FBC:MC, FlyBase:FBrf0202435]
synonym: "mutation induced by detachment" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000477
name: reduction
namespace: origin_of_mutation
def: "Mutation caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and a reduction in the number of functional copies. It leads to an aggravation of phenotype, in the case of a mutation causing a change from a wildtype to mutant phenotype or a change from a mutant to a more severe mutant phenotype." [FlyBase:FBrf0026874]
synonym: "mutation induced by reduction" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000478
name: site specific recombination
namespace: origin_of_mutation
def: "Sequence change induced by a recombination event catalyzed by a recombinase that occurs at specific nucleotide sequences." [FlyBase:FBrf0202435, ISBN:978-0-8153-3218-3]
synonym: "change induced by site specific recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000479
name: FLPase
namespace: origin_of_mutation
def: "Sequence change caused by a site specific recombination event catalyzed by the tyrosine recombinase FLPase, that recognizes minimal FLP recombination target (FRT) sites of 34 base pairs. For site specific integration, the recombination site consists of 48 base pairs containing an additional isolated base pair and a third 13 base pair direct repeat." [FlyBase:FBrf0201927, UniProt:P03870]
synonym: "change induced by FLPase recombination" EXACT []
is_a: FBcv:0000478 ! site specific recombination

[Term]
id: FBcv:0000480
name: I-SceI
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of an 18 base pair DNA sequence by the I-SceI endonuclease." [FlyBase:FBrf0128625, UniProt:P03882]
synonym: "change induced by I-SceI endonuclease cleavage" EXACT []
synonym: "SCEI endonuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage

[Term]
id: FBcv:0000481
name: cre recombinase
namespace: origin_of_mutation
def: "Sequence change induced by a site specific recombination event catalyzed by the tyrosine recombinase cre. Recombination is induced between two 34 base pairs loxP sites. These consist of two 13 base pair perfect inverted repeats flanking an 8 base pair asymmetric spacer that confers directionality." [FlyBase:FBrf0201927, PMID:6954485, UniProt:P06956]
synonym: "change induced by cre recombinase recombination" EXACT []
synonym: "Cre recombinase" RELATED []
is_a: FBcv:0000478 ! site specific recombination

[Term]
id: FBcv:0000482
name: segregation
namespace: origin_of_mutation
def: "Sequence change induced by chromosomal segregation." [FBC:MMC]
synonym: "change induced by segregation" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000483
name: transposable element activity
namespace: origin_of_mutation
def: "Mutation induced by the mobilization of a transposable element." [FBC:MC, FlyBase:FBrf0202435]
synonym: "mutation induced by transposable element activity" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000484
name: IR-hybrid dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by hybrid dysgenesis that results from the mobilization of the I-element retrotransposon." [FlyBase:FBrf0202435]
synonym: "IR" RELATED []
synonym: "mutation induced by IR-hybrid dysgenesis" EXACT []
is_a: FBcv:0003019 ! I-element activity

[Term]
id: FBcv:0000485
name: Stalker-hybrid dysgenesis
namespace: origin_of_mutation
def: "Mutation induced by hybrid dysgenesis caused by the mobilization of the Stalker transposable element." [FlyBase:FBrf0202435]
synonym: "mutation induced by Stalker-hybrid dysgenesis" EXACT []
is_a: FBcv:0003020 ! Stalker element activity

[Term]
id: FBcv:0000486
name: P-element activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by a P-element, a DNA transposable element. The P-element is 2.9 kilobases in length with 31 base pairs inverted terminal repeats. Upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion. Mobilization is induced by the activity of a P-element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000487
name: PM hybrid dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by hybrid dysgenesis that results from the action of the P-element." [FlyBase:FBrf0202435]
synonym: "mutation induced by PM hybrid dysgenesis" EXACT []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000488
name: Delta2-3 transposase
namespace: origin_of_mutation
def: "Mutation induced by the mobilization of a P-element by the Delta2-3 transposase. The source of Delta2-3 is a stable genomic integration from which the third intron has been deleted." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element mobilization by Delta2-3 transposase" EXACT []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000489
name: jumpstarter activity
namespace: origin_of_mutation
def: "Mutation caused by a P-element that is inserted into the genome and that is used to create more insertions at other sites." [FlyBase:FBrf0202435]
synonym: "Js" RELATED []
synonym: "Jumpstarter" RELATED []
synonym: "mutation induced by jumpstarter mobilization" EXACT []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000490
name: p pi25.1 supplied transposase
namespace: origin_of_mutation
def: "Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.1. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It is missing a 23 base pairs deletion of the 3' terminus compared to p pi25.1wc." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element mobilization by p pi25.1 supplied transposase" EXACT []
synonym: "p pi25.1" RELATED []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000491
name: p pi25.7wc
namespace: origin_of_mutation
def: "Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.7wc. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It has an additional 23 base pairs deletion of the 3' terminus compared to p pi25.1." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element mobilization by p pi25.7wc supplied transposase" EXACT []
synonym: "p pi25.7wc" RELATED []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000492
name: male recombination induced by dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by PM hybrid dysgenesis that is induced by the higher frequency of recombination in certain male chromosomes." [FlyBase:FBrf0202435]
synonym: "MR" RELATED []
synonym: "mutation induced by male recombination" EXACT []
is_a: FBcv:0000487 ! PM hybrid dysgenesis

[Term]
id: FBcv:0000493
name: MRh12 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event induced by a male recombination factor which is present in chromosomes extracted from a population in Haifa, Israel." [FlyBase:FBrf0202435]
synonym: "MRh12" RELATED []
synonym: "mutation induced by MRh12 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000494
name: MRT007 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event in the second and third chromosomes induced by a male recombination factor which is present in chromosomes extracted from a population in Harlingen, Texas." [FlyBase:FBrf0202435]
synonym: "MRT007" RELATED []
synonym: "mutation induced by MRT007 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000495
name: MRF23.5 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event induced by male recombination factor 23.5 MRF which is present in second chromosomes extracted from a population in Patras, Greece." [FlyBase:FBrf0039984, FlyBase:FBrf0202435]
synonym: "23.5 MRF" EXACT [FlyBase:FBrf0039984]
synonym: "MRF23.5" RELATED []
synonym: "mutation induced by MRF23.5 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000496
name: MRF31.1 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event induced by male recombination factor 31.1 MRF which is present in second chromosomes extracted from a population in Patras, Greece." [FlyBase:FBrf0030109, FlyBase:FBrf0202435]
synonym: "31.1 MRF" EXACT [FlyBase:FBrf0030109]
synonym: "MRF31.1" RELATED []
synonym: "mutation induced by MRF31.1 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000497
name: hobo activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by hobo, a DNA transposable element. The hobo element is 3.0 kilobases in length with 12 base pairs inverted terminal repeats. After mobilization by the hobo transposase and upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion." [FlyBase:FBrf0202435]
synonym: "mutation induced by hobo element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000498
name: hobo dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by hybrid dysgenesis that results from the mobilization of the hobo element." [FlyBase:FBrf0202435]
synonym: "mutation induced by hobo dysgenesis" EXACT []
is_a: FBcv:0000497 ! hobo activity

[Term]
id: FBcv:0000499
name: HBL1 supplied transposase
namespace: origin_of_mutation
def: "Mutation caused by the activity of the hobo element, mobilized by an hobo transposase which is produced from the supplied P-element helper plasmid HBL1." [FlyBase:FBrf0202435]
synonym: "Hobbled1" RELATED []
synonym: "Hobo transposase source" RELATED []
synonym: "mutation induced by Hobo transposase source HBL1" EXACT []
is_a: FBcv:0000497 ! hobo activity

[Term]
id: FBcv:0000500
name: mariner activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by mariner, a DNA transposable element. The mariner element is 1.3 kilobases in length with 28 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of these two bases upon insertion. Mobilization is induced by the activity of the mariner transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by mariner activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000501
name: gypsy element activity
namespace: origin_of_mutation
def: "Mutation induced by transposable activity caused by the gypsy retrovirus. The gypsy element is a 7.5 kilobases in length with 482 base pairs terminal repeats. Mobilization is induced by the activity of the gypsy element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by gypsy element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000502
name: piggyBac activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by piggyBac, a DNA transposable element. The piggyBac is 2.5 kilobases in length with 13 base pairs inverted terminal repeats. It specifically targets TTAA dinucleotides and generates a flanking duplication of these 4 base pairs upon insertion. Mobilization is induced by the activity of the piggyBac transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by piggyBac activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000503
name: irradiation
namespace: origin_of_mutation
def: "Mutation induced by exposure to radiation." [FBC:MMC]
synonym: "mutation induced by irradiation" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000504
name: ionizing radiation
namespace: origin_of_mutation
def: "Mutation induced by exposure to ionizing radiation." [FBC:MMC]
synonym: "mutation induced by ionizing irradiation" EXACT []
is_a: FBcv:0000503 ! irradiation

[Term]
id: FBcv:0000505
name: alpha ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to alpha rays." [FBC:MMC]
synonym: "mutation induced by alpha ray irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000506
name: gamma ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to gamma rays." [FBC:MMC]
synonym: "mutation induced by gamma ray irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000507
name: 60Co gamma ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to 60Co gamma rays." [FBC:MMC]
synonym: "mutation induced by 60Co gamma ray irradiation" EXACT []
is_a: FBcv:0000506 ! gamma ray

[Term]
id: FBcv:0000508
name: 137Cs gamma ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to 137Cs gamma rays." [FBC:MMC]
synonym: "mutation induced by 137Cs gamma ray irradiation" EXACT []
is_a: FBcv:0000506 ! gamma ray

[Term]
id: FBcv:0000509
name: 226Ra alpha ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to 226Ra alpha rays." [FBC:MMC]
synonym: "mutation induced by 226Ra alpha ray irradiation" EXACT []
synonym: "radium" RELATED []
is_a: FBcv:0000505 ! alpha ray

[Term]
id: FBcv:0000510
name: 32P
namespace: origin_of_mutation
def: "The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days (from CHEBI)." [CHEBI:37972]
synonym: "32-phosphorous" EXACT []
synonym: "mutation induced by 32-P irradiation" EXACT []
synonym: "phosphorus-32 atom" EXACT []
is_a: CHEBI:37972 ! phosphorus-32 atom
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000511
name: 3H
namespace: origin_of_mutation
def: "The radioactive isotope of hydrogen with relative atomic mass 3.016049 and half-life of 12.33 years (from Greek taurhoiotatauomicronsigma, third) (from CHEBI)." [CHEBI:29238]
synonym: "hydrogen-3" EXACT []
synonym: "mutation induced by 3H irradiation" EXACT []
synonym: "tritium atom" EXACT []
is_a: CHEBI:29238 ! tritium atom
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000512
name: 3H-deoxycytidine
namespace: origin_of_mutation
def: "Mutation induced by exposure to 3H-deoxycytidine radiation." [FBC:MMC]
synonym: "mutation induced by 3H-deoxycytidine irradiation" EXACT []
synonym: "tritiated 2'-deoxycytidine" EXACT []
synonym: "tritiated deoxycytidine" EXACT []
is_a: CHEBI:139359 ! tritiated compound
is_a: CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000513
name: 3H-thymidine
namespace: origin_of_mutation
def: "Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis (from CHEBI)." [CHEBI:53526]
synonym: "mutation induced by 3H-thymidine irradiation" EXACT []
synonym: "tritiated thymidine" EXACT []
is_a: CHEBI:53526 ! tritiated thymidine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000514
name: Bevatron
namespace: origin_of_mutation
def: "Mutation induced by treatment in a Bevatron." [FBC:MMC]
synonym: "mutation induced by Bevatron irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000515
name: deuteron
namespace: origin_of_mutation
def: "Mutation induced by exposure to deuteron radiation." [FBC:MMC]
synonym: "mutation induced by deuteron irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000516
name: neutron
namespace: origin_of_mutation
def: "Mutation induced by exposure to neutron radiation." [FBC:MMC]
synonym: "mutation induced by neutron irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000517
name: 252Cf fission neutron
namespace: origin_of_mutation
def: "Mutation induced by exposure to 252Cf fission neutron radiation." [FBC:MMC]
synonym: "mutation induced by 252Cf fission neutron irradiation" EXACT []
is_a: FBcv:0000516 ! neutron

[Term]
id: FBcv:0000518
name: X ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to X rays." [FBC:MMC]
synonym: "mutation induced by X ray irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000519
name: non-ionizing radiation
namespace: origin_of_mutation
def: "Mutation induced by exposure to non-ionizing radiation." [FBC:MMC]
synonym: "mutation induced by non-ionizing irradiation" EXACT []
is_a: FBcv:0000503 ! irradiation

[Term]
id: FBcv:0000520
name: magnetic field
namespace: origin_of_mutation
def: "Mutation induced by exposure to a magnetic field." [FBC:MMC]
synonym: "mutation induced by magnetic field irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000521
name: radio waves
namespace: origin_of_mutation
def: "Mutation induced by exposure to radio waves." [FBC:MMC]
synonym: "mutation induced by radio waves irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000522
name: stratosphere
namespace: origin_of_mutation
def: "Mutation induced by exposure to the stratosphere." [FBC:MMC]
synonym: "mutation induced by stratosphere irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000523
name: supersonic
namespace: origin_of_mutation
def: "Mutation induced by exposure to supersonic radiation." [FBC:MMC]
synonym: "mutation induced by supersonic irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000524
name: U.V.
namespace: origin_of_mutation
def: "Mutation induced by exposure to U.V. radiation." [FBC:MMC]
synonym: "mutation induced by U.V. irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000525
name: chemical
namespace: origin_of_mutation
def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances (from CHEBI)." [CHEBI:24431]
synonym: "mutation induced by chemical exposure" EXACT []
is_a: CHEBI:24431 ! chemical entity
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000526
name: alkylating agent
namespace: origin_of_mutation
def: "Any chemical (FBcv:0000525) that has role some alkylating agent (CHEBI:22333)." [CHEBI:22333]
synonym: "mutation induced by alkylating agent exposure" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: FBcv:0000525 ! chemical
intersection_of: FBcv:0000525 ! chemical
intersection_of: RO:0000087 CHEBI:22333 ! has role alkylating agent
relationship: RO:0000087 CHEBI:22333 ! has role alkylating agent

[Term]
id: FBcv:0000527
name: diethyl sulfate
namespace: origin_of_mutation
def: "The diethyl ester of sulfuric acid (from CHEBI)." [CHEBI:34699]
synonym: "DES" RELATED []
synonym: "mutation induced by diethyl sulfate exposure" EXACT []
is_a: CHEBI:34699 ! diethyl sulfate
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000528
name: 2-chloroethyl methanesulfonate
namespace: origin_of_mutation
def: "No definition for CHEBI:19508." [CHEBI:19508]
synonym: "CB1506" RELATED []
synonym: "mutation induced by 2-chloroethyl methanesulfonate exposure" EXACT []
is_a: CHEBI:19508 ! 2-chloroethyl methanesulfonate
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000529
name: 2-fluoroethyl methanesulfonate
namespace: origin_of_mutation
def: "No definition for CHEBI:19579." [CHEBI:19579]
synonym: "CB1522" RELATED []
synonym: "mutation induced by 2-fluoroethyl methanesulfonate exposure" EXACT []
is_a: CHEBI:19579 ! 2-fluoroethyl methanesulfonate
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000530
name: ethyl methanesulfonate
namespace: origin_of_mutation
def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol (from CHEBI)." [CHEBI:23994]
synonym: "CB1528" RELATED []
synonym: "EMS" RELATED []
synonym: "mutation induced by EMS exposure" EXACT []
synonym: "mutation induced by ethyl methanesulfonate exposure" EXACT []
is_a: CHEBI:23994 ! ethyl methanesulfonate
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000531
name: ethyl nitrosourea
namespace: origin_of_mutation
def: "A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups (from CHEBI)." [CHEBI:23995]
synonym: "ENU" RELATED []
synonym: "mutation induced by ENU exposure" EXACT []
synonym: "mutation induced by ethyl nitrosourea exposure" EXACT []
synonym: "N-ethyl-N-nitrosourea" RELATED [CHEBI:23995]
is_a: CHEBI:23995 ! N-ethyl-N-nitrosourea
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000532
name: hycanthon methanesulfonate
namespace: origin_of_mutation
def: "A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel (from CHEBI)." [CHEBI:24624]
synonym: "HMS" RELATED []
synonym: "hycanthone mesylate" RELATED [CHEBI:24624]
synonym: "mutation induced by HMS exposure" EXACT []
synonym: "mutation induced by hycanthon methanesulfonate exposure" EXACT []
is_a: CHEBI:24624 ! hycanthone mesylate
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000533
name: methyl methanesulfonate
namespace: origin_of_mutation
def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol (from CHEBI)." [CHEBI:25255]
synonym: "CB1540" RELATED []
synonym: "MMS" RELATED []
synonym: "mutation induced by methyl methanesulfonate exposure" EXACT []
synonym: "mutation induced by MMS exposure" EXACT []
is_a: CHEBI:25255 ! methyl methanesulfonate
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000534
name: bis(2-chloroethyl) sulfide
namespace: origin_of_mutation
alt_id: FBcv:0000536
def: "An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention (from CHEBI)." [CHEBI:25434]
synonym: "1,1'-thiobis(2-chloroethane)" RELATED [CHEBI:25434]
synonym: "CB1735" RELATED []
synonym: "mustard gas" RELATED [CHEBI:25434]
synonym: "mutation induced by bis(2-chloroethyl) sulfide exposure" EXACT []
synonym: "mutation induced by mustard gas exposure" EXACT []
synonym: "mutation induced by sulfur gas exposure" EXACT []
synonym: "sulfur mustard" RELATED [CHEBI:25434]
is_a: CHEBI:25434 ! bis(2-chloroethyl) sulfide
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000535
name: N-methyl-N'-nitro-N-nitrosoguanidine
namespace: origin_of_mutation
def: "An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position (from CHEBI)." [CHEBI:21759]
synonym: "MNNG" RELATED []
synonym: "mutation induced by N-methyl-N'-nitro-N-nitrosoguanidine exposure" EXACT []
synonym: "NNG" RELATED []
is_a: CHEBI:21759 ! N-methyl-N'-nitro-N-nitrosoguanidine
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000537
name: obsolete minos ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000538
name: carbamate
namespace: origin_of_mutation
def: "No definition for CHEBI:13941." [CHEBI:13941]
synonym: "mutation induced by carbamate exposure" EXACT []
is_a: CHEBI:13941 ! carbamate
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000539
name: urethane
namespace: origin_of_mutation
def: "A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages (from CHEBI)." [CHEBI:17967]
synonym: "mutation induced by urethane exposure" EXACT []
is_a: CHEBI:17967 ! urethane
is_a: FBcv:0000538 ! carbamate

[Term]
id: FBcv:0000540
name: vinyl carbamate
namespace: origin_of_mutation
def: "No definition for CHEBI:27292." [CHEBI:27292]
synonym: "mutation induced by vinyl carbamate exposure" EXACT []
is_a: CHEBI:27292 ! vinyl carbamate
is_a: FBcv:0000538 ! carbamate

[Term]
id: FBcv:0000541
name: intercalating agent
namespace: origin_of_mutation
def: "Any chemical (FBcv:0000525) that has role some intercalator (CHEBI:24853)." [CHEBI:24853]
synonym: "mutation induced by intercalating agent exposure" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: FBcv:0000525 ! chemical
intersection_of: FBcv:0000525 ! chemical
intersection_of: RO:0000087 CHEBI:24853 ! has role intercalator
relationship: RO:0000087 CHEBI:24853 ! has role intercalator

[Term]
id: FBcv:0000542
name: mitomycin C
namespace: origin_of_mutation
def: "No definition for CHEBI:27504." [CHEBI:27504]
synonym: "mutation induced by mitomycin C exposure" EXACT []
is_a: CHEBI:27504 ! mitomycin C
is_a: FBcv:0000526 ! alkylating agent
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000543
name: quinacrine mustard
namespace: origin_of_mutation
def: "No definition for CHEBI:37595." [CHEBI:37595]
comment: Mapped to CHEBI on basis of synonym - quinacrine mustard. Originally primary name, ICR 100 is now relegated to a synonym.
synonym: "2-methoxy-6-[3-(ethyl-2-chloroethyl)aminopropylamino]acridine" RELATED []
synonym: "ICR 100" RELATED [CHEBI:37595]
synonym: "mutation induced by quinacrine mustard exposure" EXACT []
is_a: CHEBI:37595 ! quinacrine mustard
is_a: FBcv:0000541 ! intercalating agent
is_a: FBcv:0000813 ! nitrogen mustard

[Term]
id: FBcv:0000544
name: ICR 170
namespace: origin_of_mutation
def: "No definition for CHEBI:21183." [CHEBI:21183]
synonym: "2-methoxy-6-dichloro-9-(3-ethyl-2-chloroethyl-aminopropylamino)acridine-dihydrochloride" RELATED []
synonym: "mutation induced by ICR 170 exposure" EXACT []
is_a: CHEBI:21183 ! ICR-170
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000545
name: 1,2-dibromoethane
namespace: origin_of_mutation
def: "A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae (from CHEBI)." [CHEBI:28534]
synonym: "DBE" RELATED []
synonym: "mutation induced by 1,2-dibromoethane exposure" EXACT []
is_a: CHEBI:28534 ! 1,2-dibromoethane
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000546
name: 1,2-dichloroethane
namespace: origin_of_mutation
def: "A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2 (from CHEBI)." [CHEBI:27789]
synonym: "DCE" RELATED []
synonym: "mutation induced by 1,2-dichloroethane exposure" EXACT []
is_a: CHEBI:27789 ! 1,2-dichloroethane
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000547
name: 1-bromo-2-chloroethane
namespace: origin_of_mutation
def: "A haloalkane that is bromoethane substituted by chlorine at position 2 (from CHEBI)." [CHEBI:19032]
synonym: "BCE" RELATED []
synonym: "mutation induced by 1-bromo-2-chloroethane exposure" EXACT []
is_a: CHEBI:19032 ! 1-bromo-2-chloroethane
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000548
name: base analog
namespace: origin_of_mutation
def: "A molecule that can substitute for a normal nucleobase in nucleic acids (from CHEBI)." [CHEBI:67142]
synonym: "nucleobase analogue" RELATED [CHEBI:67142]
is_a: CHEBI:67142 ! nucleobase analogue
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000549
name: 5-bromouracil
namespace: origin_of_mutation
def: "A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen (from CHEBI)." [CHEBI:20552]
synonym: "mutation induced by 5-bromouracil exposure" EXACT []
is_a: CHEBI:20552 ! 5-bromouracil
is_a: FBcv:0000548 ! base analog

[Term]
id: FBcv:0000550
name: 5-bromouridine
namespace: origin_of_mutation
def: "A uridine having a bromo substituent at the 5-position (from CHEBI)." [CHEBI:20553]
synonym: "mutation induced by 5-bromouridine exposure" EXACT []
is_a: CHEBI:20553 ! 5-bromouridine
is_a: FBcv:0000548 ! base analog

[Term]
id: FBcv:0000551
name: enzyme inhibitor
namespace: origin_of_mutation
def: "Any chemical (FBcv:0000525) that has role some enzyme inhibitor (CHEBI:23924)." [CHEBI:23924]
synonym: "mutation induced by enzyme inhibitor exposure" EXACT []
is_a: BFO:0000004 ! independent continuant
is_a: FBcv:0000525 ! chemical
intersection_of: FBcv:0000525 ! chemical
intersection_of: RO:0000087 CHEBI:23924 ! has role enzyme inhibitor
relationship: RO:0000087 CHEBI:23924 ! has role enzyme inhibitor

[Term]
id: FBcv:0000552
name: aminopterin
namespace: origin_of_mutation
def: "No definition for CHEBI:22526." [CHEBI:22526]
synonym: "mutation induced by aminopterin exposure" EXACT []
is_a: CHEBI:22526 ! 4-aminofolic acid
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000553
name: inorganic compound
namespace: origin_of_mutation
def: "A molecular entity that contains no carbon (from CHEBI)." [CHEBI:24835]
synonym: "inorganic molecular entity" EXACT [CHEBI:24835]
synonym: "mutation induced by inorganic compound exposure" EXACT []
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000554
name: cupric sulfate
namespace: origin_of_mutation
def: "A metal sulfate compound having copper(2+) as the metal ion (from CHEBI)." [CHEBI:23414]
synonym: "copper(2+) sulfate" RELATED [CHEBI:23414]
synonym: "mutation induced by cupric sulfate" EXACT []
is_a: CHEBI:23414 ! copper(II) sulfate
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000555
name: H3BO3
namespace: origin_of_mutation
def: "No definition for CHEBI:33118." [CHEBI:33118]
synonym: "mutation induced by H3BO3 exposure" EXACT []
is_a: CHEBI:33118 ! boric acid
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000556
name: sodium bisulphite
namespace: origin_of_mutation
def: "An inorganic sodium salt having hydrogensulfite as the counterion (from CHEBI)." [CHEBI:26709]
synonym: "mutation induced by sodium bisulphite exposure" EXACT []
is_a: CHEBI:26709 ! sodium hydrogensulfite
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000557
name: sodium fluoride
namespace: origin_of_mutation
def: "A metal fluoride salt with a Na(+) counterion (from CHEBI)." [CHEBI:28741]
synonym: "mutation induced by sodium fluoride exposure" EXACT []
is_a: CHEBI:28741 ! sodium fluoride
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000558
name: epoxy hydrocarbon
namespace: origin_of_mutation
def: "Mutation induced by exposure to epoxy hydrocarbon." [FBC:MMC]
synonym: "mutation induced by epoxy hydrocarbon exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000559
name: diepoxybutane
namespace: origin_of_mutation
def: "No definition for CHEBI:23704." [CHEBI:23704]
synonym: "DEB" RELATED []
synonym: "erythritol anhydride" RELATED []
synonym: "mutation induced by diepoxybutane exposure" EXACT []
is_a: CHEBI:23704 ! diepoxybutane
is_a: FBcv:0000558 ! epoxy hydrocarbon

[Term]
id: FBcv:0000560
name: diepoxyoctane
namespace: origin_of_mutation
def: "No definition for CHEBI:23705." [CHEBI:23705]
synonym: "1,2:7,8-diepoxyoctane" RELATED [CHEBI:23705]
synonym: "mutation induced by diepoxyoctane exposure" EXACT []
is_a: CHEBI:23705 ! 1,2:7,8-diepoxyoctane
is_a: FBcv:0000558 ! epoxy hydrocarbon

[Term]
id: FBcv:0000561
name: obsolete unclassified chemical
namespace: origin_of_mutation
is_obsolete: true
consider: FBcv:0000525

[Term]
id: FBcv:0000562
name: 1,2:5,6-dibenzanthracene
namespace: origin_of_mutation
def: "No definition for CHEBI:35299." [CHEBI:35299]
synonym: "mutation induced by 1,2:5,6-dibenzanthracene exposure" EXACT []
is_a: CHEBI:35299 ! dibenz[a,h]anthracene
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000563
name: 1,4-dimethanesulfonoxy-1,4-dimethylbutane
namespace: origin_of_mutation
def: "A methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups (from CHEBI)." [CHEBI:67107]
synonym: "1,4-dimethanesulfonoxy-1:4-dimethylbutane" RELATED []
synonym: "CB2348" RELATED []
synonym: "dimethylmyleran" RELATED [CHEBI:67107]
synonym: "mutation induced by 1,4-dimethanesulfonoxy-1,4-dimethylbutane exposure" EXACT []
is_a: CHEBI:67107 ! dimethylmyleran
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000564
name: 1,4-dimethanesulfonoxybut-2-yne
namespace: origin_of_mutation
def: "Mutation induced by exposure to 1,4-dimethanesulfonoxybut-2-yne." [FBC:MMC]
synonym: "CB2058" RELATED []
synonym: "mutation induced by 1,4-dimethanesulfonoxybut-2-yne exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000565
name: dominance relationship qualifier
namespace: dominance_qualifier
def: "Dominance relationships describe the dependence of the expression of a phenotypic attribute of an allele on the genotype at the locus in question. An allele might be recessive with respect to one phenotypic attribute, but dominant with respect to another." [FBC:rd]
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000566
name: 1,6-dimethylsulfonoxy D-mannitol
namespace: origin_of_mutation
def: "Mutation induced by exposure to 1,6-dimethylsulfonoxy D-mannitol." [FBC:MMC]
synonym: "CB2511" RELATED []
synonym: "mutation induced by 1,6-dimethylsulfonoxy D-mannitol exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000567
name: 1,6-dimethylsulfonoxy L-mannitol
namespace: origin_of_mutation
def: "Mutation induced by exposure to 1,6-dimethylsulfonoxy L-mannitol." [FBC:MMC]
synonym: "CB2628" RELATED []
synonym: "mutation induced by 1,6-dimethylsulfonoxy L-mannitol exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000568
name: 1-amino-2-naphthol-4-sulfonic acid
namespace: origin_of_mutation
def: "No definition for CHEBI:19024." [CHEBI:19024]
synonym: "mutation induced by 1-amino-2-naphthol-4-sulfonic acid exposure" EXACT []
is_a: CHEBI:19024 ! 4-amino-3-hydroxynaphthalene-1-sulfonic acid
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000569
name: lucanthone
namespace: origin_of_mutation
def: "A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone (from CHEBI)." [CHEBI:51052]
synonym: "1-diethylaminoethylethylamino-4-methyl-thioxanthenone" RELATED []
synonym: "1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one" RELATED [CHEBI:51052]
synonym: "lucanthone" RELATED [CHEBI:51052]
synonym: "mutation induced by lucanthone exposure" EXACT []
is_a: CHEBI:51052 ! lucanthone
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000570
name: 2-methoxyethanol
namespace: origin_of_mutation
def: "A hydroxyether that is ethanol substituted by a methoxy group at position 2 (from CHEBI)." [CHEBI:46790]
synonym: "mutation induced by 2-methoxyethanol exposure" EXACT []
is_a: CHEBI:46790 ! 2-methoxyethanol
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000571
name: 2,5-bis(ethyleneimino)-1,4-benzoquinone
namespace: origin_of_mutation
def: "A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups (from CHEBI)." [CHEBI:19363]
synonym: "2,5,-bisethylene-imine-1,4-benzoquinone" RELATED []
synonym: "mutation induced by 2,5-bis(ethyleneimino)-1,4-benzoquinone exposure" EXACT []
is_a: CHEBI:19363 ! 2,5-bis(aziridin-1-yl)-1,4-benzoquinone
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000572
name: 7-bromomethyl-12-methylbenz[a]anthracene
namespace: origin_of_mutation
def: "A member of the class of tetraphenes that is tetraphene in which the hydrogens at positions 7 and 12 are replaced by bromomethyl and methyl groups, respectively (from CHEBI)." [CHEBI:20787]
synonym: "7-bromomethyl 12 methyl benzalpha anthracine" RELATED []
synonym: "7-bromomethyl-12-methyltetraphene" RELATED [CHEBI:20787]
synonym: "mutation induced by 7-bromomethyl-12-methylbenz[a]anthracene exposure" EXACT []
is_a: CHEBI:20787 ! 7-bromomethyl-12-methyltetraphene
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000573
name: actinomycin D
namespace: origin_of_mutation
def: "No definition for CHEBI:27666." [CHEBI:27666]
synonym: "mutation induced by actinomycin D exposure" EXACT []
is_a: CHEBI:27666 ! actinomycin D
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000574
name: benzo(alpha)pyrene
namespace: origin_of_mutation
def: "An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings (from CHEBI)." [CHEBI:29865]
synonym: "benzo[a]pyrene" RELATED [CHEBI:29865]
synonym: "mutation induced by benzo(alpha)pyrene exposure" EXACT []
is_a: CHEBI:29865 ! benzo[a]pyrene
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000575
name: caffeine
namespace: origin_of_mutation
def: "A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee (from CHEBI)." [CHEBI:27732]
synonym: "mutation induced by caffeine exposure" EXACT []
is_a: CHEBI:27732 ! caffeine
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000576
name: cisplatin
namespace: origin_of_mutation
def: "A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups) (from CHEBI)." [CHEBI:27899]
synonym: "cis-dichlorodiammineplatinum(II)" RELATED []
synonym: "mutation induced by cisplatin exposure" EXACT []
is_a: CHEBI:27899 ! cisplatin
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000577
name: colchicine
namespace: origin_of_mutation
def: "An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum (from CHEBI)." [CHEBI:23359]
synonym: "mutation induced by colchicine exposure" EXACT []
is_a: CHEBI:23359 ! colchicine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000578
name: dimethyl sulfoxide
namespace: origin_of_mutation
def: "A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents (from CHEBI)." [CHEBI:28262]
synonym: "mutation induced by dimethyl sulfoxide exposure" EXACT []
is_a: CHEBI:28262 ! dimethyl sulfoxide
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000579
name: DNA
namespace: origin_of_mutation
def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms (from CHEBI)." [CHEBI:16991]
synonym: "mutation induced by DNA treatment" EXACT []
is_a: CHEBI:16991 ! deoxyribonucleic acid
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000580
name: ethyl ether
namespace: origin_of_mutation
def: "An ether in which the oxygen atom is linked to two ethyl groups (from CHEBI)." [CHEBI:35702]
synonym: "mutation induced by ethyl ether exposure" EXACT []
is_a: CHEBI:35702 ! diethyl ether
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000581
name: ethylenimine
namespace: origin_of_mutation
def: "No definition for CHEBI:30969." [CHEBI:30969]
synonym: "EI" RELATED []
synonym: "mutation induced by ethylenimine exposure" EXACT []
is_a: CHEBI:30969 ! aziridine
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000582
name: ethylene oxide
namespace: origin_of_mutation
def: "A  saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom (from CHEBI)." [CHEBI:27561]
synonym: "ethylene oxide" RELATED [CHEBI:27561]
synonym: "mutation induced by ethylene oxide exposure" EXACT []
synonym: "oxirane" RELATED [CHEBI:27561]
is_a: CHEBI:27561 ! oxirane
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000583
name: fagaronine
namespace: origin_of_mutation
def: "No definition for CHEBI:28954." [CHEBI:28954]
synonym: "mutation induced by fagaronine exposure" EXACT []
is_a: CHEBI:28954 ! fagaronine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000584
name: formaldehyde
namespace: origin_of_mutation
def: "An aldehyde resulting from the formal oxidation of methanol (from CHEBI)." [CHEBI:16842]
synonym: "mutation induced by formaldehyde exposure" EXACT []
is_a: CHEBI:16842 ! formaldehyde
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000585
name: hesperidine
namespace: origin_of_mutation
def: "A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage (from CHEBI)." [CHEBI:28775]
synonym: "hesperidin" RELATED [CHEBI:28775]
synonym: "mutation induced by hesperidine exposure" EXACT []
is_a: CHEBI:28775 ! hesperidin
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000586
name: hexamethylmelamine
namespace: origin_of_mutation
def: "No definition for CHEBI:24564." [CHEBI:24564]
synonym: "altretamine" RELATED []
synonym: "HMM" RELATED []
synonym: "mutation induced by hexamethylmelamine exposure" EXACT []
synonym: "mutation induced by HMM exposure" EXACT []
is_a: CHEBI:24564 ! hexamethylmelamine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000587
name: hexamethylphosphoramide
namespace: origin_of_mutation
def: "No definition for CHEBI:24565." [CHEBI:24565]
synonym: "HMPA" RELATED []
synonym: "mutation induced by hexamethylphosphoramide exposure" EXACT []
synonym: "mutation induced by HMPA exposure" EXACT []
is_a: CHEBI:24565 ! hexamethylphosphoric triamide
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000588
name: iodine
namespace: origin_of_mutation
def: "Chemical element with atomic number 53 (from CHEBI)." [CHEBI:24859]
synonym: "mutation induced by iodine exposure" EXACT []
is_a: CHEBI:24859 ! iodine atom
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000589
name: Janus green B
namespace: origin_of_mutation
def: "No definition for CHEBI:21184." [CHEBI:21184]
synonym: "Janus green B chloride" RELATED [CHEBI:21184]
synonym: "mutation induced by Janus green B exposure" EXACT []
is_a: CHEBI:21184 ! Janus Green B chloride
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000590
name: methoxy diethylnitrosamine
namespace: origin_of_mutation
def: "No definition for CHEBI:25234." [CHEBI:25234]
comment: Mapped to CHEBI:25234 (1-methoxy-N-nitrosodiethylamine) based on synonym of nitrosodiethylamine being diethylnitrosamine and CHEBI:25234 being classified as a mutagen.
synonym: "1-methoxy-N-nitrosodiethylamine" RELATED [CHEBI:25234]
synonym: "mutation induced by methoxy diethylnitrosamine exposure" EXACT []
is_a: CHEBI:25234 ! 1-methoxy-N-nitrosodiethylamine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000591
name: natural gas
namespace: origin_of_mutation
def: "Mutation induced by exposure to natural gas." [FBC:MMC]
synonym: "mutation induced by natural gas exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000592
name: nitrosomethyl urea
namespace: origin_of_mutation
def: "A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups (from CHEBI)." [CHEBI:50102]
synonym: "MNU" RELATED []
synonym: "mutation induced by MNU exposure" EXACT []
synonym: "mutation induced by nitrosomethyl urea exposure" EXACT []
synonym: "N-methyl-N-nitrosourea" RELATED [CHEBI:50102]
is_a: CHEBI:50102 ! N-methyl-N-nitrosourea
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000593
name: N-nitrosodimethylamine
namespace: origin_of_mutation
def: "No definition for CHEBI:35807." [CHEBI:35807]
synonym: "DMN" RELATED []
synonym: "mutation induced by DMN exposure" EXACT []
synonym: "mutation induced by N-nitrosodimethylamine exposure" EXACT []
is_a: CHEBI:35807 ! N-nitrosodimethylamine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000594
name: p-N,N-di(2-chloroethyl)aminophenylvaleric acid
namespace: origin_of_mutation
def: "No definition for CHEBI:25813." [CHEBI:25813]
synonym: "CB1356" RELATED []
synonym: "mutation induced by p-N,N-di(2-chloroethyl)aminophenylvaleric acid exposure" EXACT []
is_a: CHEBI:25813 ! p-N,N-bis(2-chloroethyl)aminophenylvaleric acid
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000595
name: p-N,N-di-(2-chloroethyl)amino-D-phenylalanine
namespace: origin_of_mutation
def: "No definition for CHEBI:25814." [CHEBI:25814]
synonym: "CB3026" RELATED []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)amino-D-phenylalanine exposure" EXACT []
is_a: CHEBI:25814 ! p-N,N-bis(2-chloroethyl)amino-D-phenylalanine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000596
name: p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine
namespace: origin_of_mutation
def: "A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring (from CHEBI)." [CHEBI:28876]
synonym: "CB3007" RELATED []
synonym: "melphalan" RELATED [CHEBI:28876]
synonym: "mutation induced by melphalan exposure" EXACT []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine exposure" EXACT []
is_a: CHEBI:28876 ! melphalan
is_a: FBcv:0000813 ! nitrogen mustard

[Term]
id: FBcv:0000597
name: p-N,N-di-(2-chloroethyl)amino-L-phenylalanine
namespace: origin_of_mutation
def: "No definition for CHEBI:25816." [CHEBI:25816]
synonym: "CB3025" RELATED []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)amino-L-phenylalanine exposure" EXACT []
is_a: CHEBI:25816 ! p-N,N-bis(2-chloroethyl)amino-L-phenylalanine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000598
name: obsolete dominant temperature-sensitive lethal balancer
comment: Consider - FBsv:0001009.
is_obsolete: true

[Term]
id: FBcv:0000599
name: p-N,N-di-(2-chloroethyl)aminophenylethylamine
namespace: origin_of_mutation
def: "No definition for CHEBI:25818." [CHEBI:25818]
synonym: "CB3034" RELATED []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)aminophenylethylamine exposure" EXACT []
is_a: CHEBI:25818 ! 4-(2-aminoethyl)-N,N-bis(2-chloroethyl)aniline
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000600
name: p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine
namespace: origin_of_mutation
def: "No definition for CHEBI:25829." [CHEBI:25829]
synonym: "CB305" RELATED []
synonym: "mutation induced by p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine exposure" EXACT []
is_a: CHEBI:25829 ! p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000601
name: quinhydrone
namespace: origin_of_mutation
def: "No definition for CHEBI:26491." [CHEBI:26491]
synonym: "mutation induced by quinhydrone exposure" EXACT []
is_a: CHEBI:26491 ! quinhydrone
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000602
name: S-2-chloroethylcysteine
namespace: origin_of_mutation
def: "No definition for CHEBI:22025." [CHEBI:22025]
synonym: "CB1592" RELATED []
synonym: "mutation induced by S-2-chloroethylcysteine exposure" EXACT []
is_a: CHEBI:22025 ! S-2-chloroethylcysteine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000603
name: styryl quinoline
namespace: origin_of_mutation
def: "No definition for CHEBI:26800." [CHEBI:26800]
synonym: "CB3086" RELATED []
synonym: "mutation induced by styryl quinoline exposure" EXACT []
is_a: CHEBI:26800 ! styrylquinoline
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000604
name: triaziquone
namespace: origin_of_mutation
def: "A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups (from CHEBI)." [CHEBI:27090]
synonym: "mutation induced by triaziquone exposure" EXACT []
is_a: CHEBI:27090 ! triaziquone
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000605
name: triethylenemelamine
namespace: origin_of_mutation
def: "No definition for CHEBI:27919." [CHEBI:27919]
synonym: "CB1246" RELATED []
synonym: "mutation induced by triethylenemelamine exposure" EXACT []
synonym: "TEM" RELATED []
synonym: "tretamine" RELATED [CHEBI:27919]
is_a: CHEBI:27919 ! tretamine
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000606
name: obsolete allele assay method
namespace: mode_of_assay
def: "Assay method used to generate an allele." [FBC:MMC]
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000607
name: obsolete In transgenic Drosophila
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000608
name: obsolete Whole-organism transient assay
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000609
name: obsolete Drosophila cell culture
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000610
name: obsolete In transgenic Drosophila (allele of one drosophilid species in genome of another drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000611
name: obsolete Whole-organism transient assay (allele from one drosophilid species assayed in another drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000612
name: obsolete In transgenic Drosophila (allele of foreign species in genome of drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000613
name: obsolete Whole-organism transient assay (allele of foreign species assayed in drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000614
name: obsolete stock descriptor
comment: Consider - FBsv:0000000.
is_obsolete: true

[Term]
id: FBcv:0000615
name: obsolete extracted wild-type chromosome
is_obsolete: true

[Term]
id: FBcv:0000616
name: obsolete laboratory stock
comment: I don't think this is a useful term.
is_obsolete: true

[Term]
id: FBcv:0000617
name: obsolete selected wild-type stock
is_obsolete: true

[Term]
id: FBcv:0000618
name: obsolete wild-type stock
comment: Consider - FBsv:0001005.
is_obsolete: true

[Term]
id: FBcv:0000619
name: obsolete isogenic stock
comment: Consider - FBsv:0001002.
is_obsolete: true

[Term]
id: FBcv:0000620
name: genetic interaction qualifier
namespace: genetic_interaction_type
def: "Qualifier that describes the relation between two phenotypes that are due to genotypes g1 and g2." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000621
name: suppressor
namespace: genetic_interaction_type
def: "The genotype g1 is a suppressor of genotype g2 if (and only if) the phenotype due to g2 is made less severe by g1." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (suppressible).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000622
name: suppressible
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is suppressible by genotype g2 if the if the phenotype due to the genotype g1g2 is less severe than that due to g1 alone." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000623
name: enhancer
namespace: genetic_interaction_type
def: "Genotype g1 is enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (enhanceable).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000624
name: enhanceable
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000625
name: non-enhancer
namespace: genetic_interaction_type
def: "Genotype g1 is a non-enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is not more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:MMC, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (non-enhanceable).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000626
name: non-enhanceable
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is non-enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000627
name: non-suppressor
namespace: genetic_interaction_type
def: "The genotype g1 is a non-suppressor of genotype g2 if (and only if) the phenotype due to g2 is not made less severe by g1." [FBC:MMC, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (non-suppressible).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000628
name: non-suppressible
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is non-suppressible by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no less severe than the phenotype due to g1 alone." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000629
name: obsolete dominant temperature-sensitive lethal balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000630
name: obsolete dominant temperature-sensitive lethal balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000631
name: obsolete DrosDel Project deficiency core kit stock
is_obsolete: true

[Term]
id: FBcv:0000632
name: obsolete Bloomington Stock Center deficiency kit stock
comment: Consider - FBsv:0000601.
is_obsolete: true

[Term]
id: FBcv:0000633
name: obsolete Exelixis deficiency kit stock
is_obsolete: true

[Term]
id: FBcv:0000634
name: obsolete duplication kit stock
is_obsolete: true

[Term]
id: FBcv:0000635
name: obsolete Cambridge 2 duplication kit stock
comment: Consider - FBsv:0000603.
is_obsolete: true

[Term]
id: FBcv:0000636
name: obsolete Bloomington duplication kit stock
comment: Consider - FBsv:0000602.
is_obsolete: true

[Term]
id: FBcv:0000637
name: obsolete Gene Disruption Project stock
is_obsolete: true

[Term]
id: FBcv:0000638
name: obsolete sequenced strain
comment: Consider - FBsv:0001003.
is_obsolete: true

[Term]
id: FBcv:0000639
name: obsolete Golic gene replacement kit stock
comment: Consider - FBsv:0000604.
is_obsolete: true

[Term]
id: FBcv:0000640
name: obsolete Golic laboratory gene replacement kit stock
is_obsolete: true

[Term]
id: FBcv:0000641
name: obsolete stock by cytotype
is_obsolete: true

[Term]
id: FBcv:0000642
name: obsolete H cytotype stock
is_obsolete: true

[Term]
id: FBcv:0000643
name: obsolete hobo family transposable element insertions present
is_obsolete: true

[Term]
id: FBcv:0000644
name: obsolete hobo family transposable element insertions absent
is_obsolete: true

[Term]
id: FBcv:0000645
name: obsolete P cytotype stock
is_obsolete: true

[Term]
id: FBcv:0000646
name: obsolete P-element family transposable element insertions absent
is_obsolete: true

[Term]
id: FBcv:0000647
name: obsolete P-element family transposable element insertions present
is_obsolete: true

[Term]
id: FBcv:0000648
name: obsolete mapping stock
is_obsolete: true

[Term]
id: FBcv:0000649
name: obsolete visible allele recombination mapping stock
is_obsolete: true

[Term]
id: FBcv:0000650
name: editorial
namespace: pub_type
def: "Work consisting of a statement of the opinions, beliefs, and policy of the editor or publisher of a journal, usually on current matters of medical or scientific significance to the medical community or society at large." [MeSH:D016421]
xref: MeSH:D016421
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000651
name: obsolete meeting report
namespace: pub_type
comment: This term was obsoleted to conform with the MeSH terms used by PubMed. Please use 'FBcv:0000199
is_obsolete: true
replaced_by: FBcv:0000199

[Term]
id: FBcv:0000652
name: compendium
namespace: pub_type
def: "A publication containing a collection of separate articles written by distinct authors." [FBC:SM]
synonym: "multipub" EXACT [FBC:SM]
synonym: "multipublication" EXACT [FBC:SM]
synonym: "Parent publication" EXACT [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000653
name: subset
namespace: expression_qualifier
def: "Restricted to unknown subtype(s) of a specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000654
name: embryonic pattern qualifier
namespace: embryonic_pattern_qualifier
def: "Qualifier that describes the expression pattern of an embryo." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000655
name: obsolete Vienna Drosophila RNAi Center
comment: Consider - FBsv:0000107.
synonym: "VDRC" EXACT []
synonym: "Vienna" EXACT []
is_obsolete: true

[Term]
id: FBcv:0000656
name: obsolete frozen specimen
comment: Consider - FBsv:0000008.
is_obsolete: true

[Term]
id: FBcv:0000657
name: obsolete mutant stock
is_obsolete: true

[Term]
id: FBcv:0000658
name: obsolete DrosDel Project deficiency stock
is_obsolete: true

[Term]
id: FBcv:0000659
name: obsolete deficiency stock
is_obsolete: true

[Term]
id: FBcv:0000660
name: obsolete inbred line
comment: Consider - FBsv:0000501.
is_obsolete: true

[Term]
id: FBcv:0000661
name: obsolete isofemale line
comment: Consider - FBsv:0000502.
is_obsolete: true

[Term]
id: FBcv:0000662
name: obsolete recently collected stock
def: "A stock established from flies collected in the wild within the past 3 years." [FBC:KM]
comment: Consider - FBsv:0000504.
is_obsolete: true

[Term]
id: FBcv:0000663
name: obsolete transposable element-containing stock
is_obsolete: true

[Term]
id: FBcv:0000664
name: obsolete duplication stock
is_obsolete: true

[Term]
id: FBcv:0000665
name: abnormal body size
namespace: phenotypic_class
def: "Phenotype that is an abnormality in body size compared to wild-type animals raised under the same conditions as the animals exhibiting the phenotype." [FBC:DOS]
synonym: "body size defective" EXACT []
is_a: FBcv:0000354 ! visible
is_a: FBcv:0000357 ! abnormal size

[Term]
id: FBcv:0000666
name: obsolete conference proceedings
namespace: pub_type
comment: This term was obsoleted to conform with the MeSH terms used by PubMed. Please use 'FBcv:0000199
is_obsolete: true
replaced_by: FBcv:0000199

[Term]
id: FBcv:0000667
name: website
namespace: pub_type
def: "A set of related web pages containing content such as text, images, video, audio, etc., prepared and maintained as a collection of information on a particular subject." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000668
name: abnormal cell adhesion
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.'" [FBC:DOS, GOC:hb, GOC:pf]
subset: fbcvsubset_mgiribbons
synonym: "cell adhesion defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000669
name: abnormal hatching behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in hatching behavior (GO:0035187). 'hatching behavior' is defined as: 'The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell.'" [FBC:DOS, GOC:pr, PMID:10436051]
synonym: "hatching behavior defective" EXACT []
synonym: "hatching behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000670
name: abnormal eclosion
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eclosion (GO:0007562). 'eclosion' is defined as: 'The emergence of an adult insect from a pupa case.'" [FBC:DOS, GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]
subset: fbcvsubset_mgiribbons
synonym: "eclosion defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000671
name: abnormal cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell cycle (GO:0007049). 'cell cycle' is defined as: 'The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.'" [FBC:DOS, GOC:go_curators, GOC:mtg_cell_cycle]
subset: fbcvsubset_mgiribbons
synonym: "cell cycle defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000672
name: abnormal endomitotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in endomitotic cell cycle (GO:0007113). 'endomitotic cell cycle' is defined as: 'A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.'" [FBC:DOS, GOC:curators, GOC:dos, GOC:expert_vm]
synonym: "endocycle defective" EXACT []
synonym: "endomitotic cell cycle defective" EXACT []
is_a: FBcv:0000432 ! abnormal mitotic cell cycle

[Term]
id: FBcv:0000673
name: obsolete sequenced whole genome stock
comment: Consider - FBsv:0001003.
is_obsolete: true

[Term]
id: FBcv:0000674
name: obsolete phiC31 based integration system
is_obsolete: true

[Term]
id: FBcv:0000675
name: obsolete phiC31 docking site stock
is_obsolete: true

[Term]
id: FBcv:0000676
name: obsolete multi-female collection
comment: Consider - FBsv:0000503.
is_obsolete: true

[Term]
id: FBcv:0000677
name: 60-70% egg length
namespace: spatial_qualifier
def: "60-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2009-05-28T03:54:39Z" xsd:dateTime

[Term]
id: FBcv:0000678
name: 80-100% egg length
namespace: spatial_qualifier
def: "80-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2009-05-28T03:55:30Z" xsd:dateTime

[Term]
id: FBcv:0000679
name: abnormal circadian behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian behavior (GO:0048512). 'circadian behavior' is defined as: 'The specific behavior of an organism that recurs with a regularity of approximately 24 hours.'" [FBC:DOS, GOC:bf, GOC:go_curators, GOC:pr]
synonym: "circadian behavior defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
is_a: FBcv:0000394 ! abnormal circadian rhythm
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2009-11-30T11:06:35Z" xsd:dateTime

[Term]
id: FBcv:0000680
name: abnormal proboscis extension reflex
namespace: phenotypic_class
def: "Phenotype that is any abnormality in proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'" [FB:FBrf0044924, FBC:DOS, GOC:jid]
synonym: "proboscis extension reflex defective" EXACT []
is_a: FBcv:0000403 ! abnormal chemosensory behavior

[Term]
id: FBcv:0000681
name: abnormal sensory perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception (GO:0007600). 'sensory perception' is defined as: 'The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.'" [FBC:DOS, GOC:ai, GOC:dph]
subset: fbcvsubset_mgiribbons
synonym: "sensory perception defective" EXACT []
is_a: FBcv:0001347 ! phenotype
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-02-23T12:28:26Z" xsd:dateTime

[Term]
id: FBcv:0000682
name: abnormal touch perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of touch (GO:0050975). 'sensory perception of touch' is defined as: 'The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).'" [FBC:DOS, GOC:ai]
synonym: "touch perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000683
name: abnormal temperature response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to temperature stimulus (GO:0009266). 'response to temperature stimulus' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.'" [FBC:DOS, GOC:hb]
subset: fbcvsubset_mgiribbons
synonym: "temperature response defective" EXACT []
is_a: FBcv:0001347 ! phenotype
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-02-23T12:51:02Z" xsd:dateTime

[Term]
id: FBcv:0000684
name: abnormal cold stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to cold (GO:0009409). 'response to cold' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.'" [FBC:DOS, GOC:lr]
synonym: "cold stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
is_a: FBcv:0000683 ! abnormal temperature response
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-02-23T02:11:27Z" xsd:dateTime

[Term]
id: FBcv:0000685
name: parental effect
namespace: genotype_to_phenotype_relation
def: "Parental effects describe the dependence of the expression of a phenotypic attribute of an allele on the parent from which that allele is inherited." [FBC:rd]
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000686
name: abnormal axis specification
namespace: phenotypic_class
def: "Phenotype that is any abnormality in axis specification (GO:0009798). 'axis specification' is defined as: 'The establishment, maintenance and elaboration of a pattern along a line or around a point.'" [FBC:DOS, GOC:dph, GOC:go_curators, GOC:isa_complete]
comment: This phenotypic class does not encompass planar polarity.
subset: fbcvsubset_mgiribbons
synonym: "axis specification defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000687
name: balancer descriptor
def: "Descriptor that relates to aspects of a balancer." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0000688
name: amorphic allele
namespace: allele_class
def: "An allele that completely lacks function, coding either for a completely inactive gene product or none at all." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "amorph" RELATED []
synonym: "null" RELATED []
is_a: FBcv:0000287 ! loss of function allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T03:57:21Z" xsd:dateTime

[Term]
id: FBcv:0000689
name: amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function, producing either a completely inactive gene product or none at all." [FlyBase:FBrf0049147]
synonym: "molecular null" EXACT []
is_a: FBcv:0000688 ! amorphic allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T03:57:49Z" xsd:dateTime

[Term]
id: FBcv:0000690
name: hypomorphic allele
namespace: allele_class
def: "Allele that makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "hypomorph" EXACT []
is_a: FBcv:0000287 ! loss of function allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T03:58:15Z" xsd:dateTime

[Term]
id: FBcv:0000691
name: hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FlyBase:FBrf0049147]
is_a: FBcv:0000690 ! hypomorphic allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T03:59:31Z" xsd:dateTime

[Term]
id: FBcv:0000692
name: neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern compared to wild-type." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000697 ! neomorphic allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T04:01:04Z" xsd:dateTime

[Term]
id: FBcv:0000693
name: hypermorphic allele - molecular evidence
namespace: allele_class
def: "Allele shown by molecular evidence to make either a functionally wild-type gene product at increased levels or a gene product with the same function as wild-type but with increased activity." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000696 ! hypermorphic allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T04:01:04Z" xsd:dateTime

[Term]
id: FBcv:0000694
name: antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product." [FlyBase:FBrf0049147]
synonym: "dominant negative" RELATED []
is_a: FBcv:0000695 ! antimorphic allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T04:01:04Z" xsd:dateTime

[Term]
id: FBcv:0000695
name: antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "antimorph" RELATED []
is_a: FBcv:0000290 ! gain of function allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T04:02:05Z" xsd:dateTime

[Term]
id: FBcv:0000696
name: hypermorphic allele
namespace: allele_class
def: "An allele that makes either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "hypermorph" RELATED []
is_a: FBcv:0000290 ! gain of function allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T04:02:45Z" xsd:dateTime

[Term]
id: FBcv:0000697
name: neomorphic allele
namespace: allele_class
def: "An allele that makes a gene product with a novel function or expression pattern compared to wild-type." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "neomorph" RELATED []
is_a: FBcv:0000290 ! gain of function allele
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-06T04:03:33Z" xsd:dateTime

[Term]
id: FBcv:0000698
name: embryonic/larval segmentation phenotype
namespace: phenotypic_class
def: "A phenotype that is a disruption in the wild-type pattern of segments or parasegments of the embryo or larva." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000699
name: pair rule phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of alternate segments or parasegments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype

[Term]
id: FBcv:0000700
name: even pair-rule phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of even segments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000699 ! pair rule phenotype

[Term]
id: FBcv:0000701
name: odd pair-rule phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of odd segments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000699 ! pair rule phenotype

[Term]
id: FBcv:0000702
name: segment polarity phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype in which some fraction of each segment (along the anterior-posterior axis) is deleted and replaced by a mirror image duplication of the remaining part of the segment." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype

[Term]
id: FBcv:0000703
name: gap phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete loss of a contiguous stretch of 2 or more segments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype

[Term]
id: FBcv:0000704
name: chemical conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence or absence of some specific chemical whose presence or absence does not induce the same defect in wild-type animals." [FBC:DOS]
is_a: FBcv:0000309 ! conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-20T11:13:19Z" xsd:dateTime

[Term]
id: FBcv:0000705
name: abnormal sleep
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sleep (GO:0030431). 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.'" [FBC:DOS, ISBN:0192800981]
subset: fbcvsubset_mgiribbons
synonym: "sleep defective" EXACT []
is_a: FBcv:0001347 ! phenotype
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-20T12:06:13Z" xsd:dateTime

[Term]
id: FBcv:0000706
name: abnormal diapause
namespace: phenotypic_class
def: "Phenotype that is any abnormality in entry into diapause (GO:0055115). 'entry into diapause' is defined as: 'The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation.'" [FBC:DOS, GOC:ds, GOC:jid, GOC:mah]
synonym: "diapause defective" EXACT []
is_a: FBcv:0001347 ! phenotype
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-20T12:06:28Z" xsd:dateTime

[Term]
id: FBcv:0000707
name: abnormal reproductive diapause
namespace: phenotypic_class
def: "Phenotype that is any abnormality in entry into reproductive diapause (GO:0055116). 'entry into reproductive diapause' is defined as: 'The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli.'" [FBC:DOS, GOC:ds, GOC:jid, GOC:mah]
synonym: "reproductive diapause defective" EXACT []
is_a: FBcv:0000706 ! abnormal diapause
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2010-09-20T12:21:29Z" xsd:dateTime

[Term]
id: FBcv:0000708
name: abnormal starvation stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to starvation (GO:0042594). 'response to starvation' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.'" [FBC:DOS, GOC:go_curators]
synonym: "starvation stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000709
name: abnormal cell number
namespace: phenotypic_class
def: "Phenotype that is an increase or decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by defects in cell growth - there may be a greater or lesser number of cells in an otherwise normal volume of tissue." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell number defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000710
name: gene targeting by homologous recombination
namespace: origin_of_mutation
def: "Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double stranded break in an engineered donor construct that contains sequence homologous to the target gene." [FBC:MC, FlyBase:FBrf0202435]
comment: Strictly, homologous recombinational repair (GO:0000724) defines only the endogenous process, not its use for engineered gene targeting.
synonym: "change induced by gene targeting via homologous recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000711
name: ends-out gene targeting
namespace: origin_of_mutation
def: "Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break on both sides of the homologous region in an engineered donor sequence. This double-strand break is usually generated by cutting at a single site adjacent to the homologous region in a circularized donor sequence. This typically generates a simple targeted replacement of the target sequence by the donor sequence. However, more complicated outcomes are possible." [FBC:MC, FlyBase:FBrf0167363, FlyBase:FBrf0202435]
synonym: "change induced by ends-out gene targeting" EXACT []
is_a: FBcv:0000710 ! gene targeting by homologous recombination

[Term]
id: FBcv:0000712
name: ends-in gene targeting
namespace: origin_of_mutation
def: "Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break within an engineered homologous donor sequence. This typically generates a tandem duplication of the homologous sequence from the donor, separated by the remainder of the incoming donor DNA. However, more complicated outcomes are possible." [FBC:MC, FlyBase:FBrf0167363, FlyBase:FBrf0202435]
synonym: "change induced by ends-in gene targeting" EXACT []
is_a: FBcv:0000710 ! gene targeting by homologous recombination

[Term]
id: FBcv:0000713
name: jumpless
namespace: phenotypic_class
def: "Phenotype that is a inability to jump. This may be due to neurological or muscular defects." [FBC:DOS]
is_a: FBcv:0000415 ! abnormal jumping
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-03-10T04:57:06Z" xsd:dateTime

[Term]
id: FBcv:0000714
name: nutrition conditional
namespace: environmental_qualifier
def: "Phenotype only expressed under some specific nutritional regime." [FBC:DOS]
is_a: FBcv:0000309 ! conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-01-14T12:34:01Z" xsd:dateTime

[Term]
id: FBcv:0000715
name: calorie restriction conditional
namespace: environmental_qualifier
def: "Phenotype only expressed under conditions where calorie intake is restricted." [FBC:DOS]
is_a: FBcv:0000714 ! nutrition conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-01-14T05:12:37Z" xsd:dateTime

[Term]
id: FBcv:0000716
name: abnormal cell migration
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell migration (GO:0016477). 'cell migration' is defined as: 'The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.'" [FBC:DOS, GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
subset: fbcvsubset_mgiribbons
synonym: "cell migration defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000717
name: increased cell growth rate
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
is_a: FBcv:0000427 ! abnormal cell growth

[Term]
id: FBcv:0000718
name: decreased cell growth rate
namespace: phenotypic_class
def: "Phenotype that is an decrease in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "reduced cell growth rate" EXACT []
is_a: FBcv:0000427 ! abnormal cell growth

[Term]
id: FBcv:0000719
name: atrophy
namespace: phenotypic_class
def: "Phenotype that is a decrease in size of an initially normally sized organ or tissue due to wasting away of cells." [FBC:DOS]
is_a: FBcv:0007508 ! decreased size
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-03-10T05:59:04Z" xsd:dateTime

[Term]
id: FBcv:0000720
name: abnormal jump response
namespace: phenotypic_class
def: "Phenotype that is any abnormality or in or absence of a jump response (GO:0007630). The jump response in Drosophila is a reflex escape response that can be triggered by a number of signals including odor and light. Standard assays are commonly used to test odor and light induced jump response." [FlyBase:FBrf0187887, FlyBase:FBrf0191819]
synonym: "jump response defective" EXACT []
is_a: FBcv:0000415 ! abnormal jumping
is_a: FBcv:0007529 ! abnormal adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-03-11T08:03:28Z" xsd:dateTime

[Term]
id: FBcv:0000721
name: abnormal mating behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'" [FBC:DOS, GOC:ai, GOC:dph]
synonym: "mating behavior defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
is_a: FBcv:0000400 ! abnormal mating

[Term]
id: FBcv:0000722
name: somatic clone - Minute background
namespace: clone_qualifier
def: "A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that is part of and derived from an animal with a different genotype that includes being Minute +/-." [FBC:DOS]
is_a: FBcv:0000336 ! somatic clone
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-01-27T04:55:28Z" xsd:dateTime

[Term]
id: FBcv:0000723
name: neoplasia
namespace: phenotypic_class
def: "Phenotype that consists of abnormal growth of a tissue or organ due to increased numbers of cells, but in which the affected tissue or organ does not maintain its normal form." [FBC:DOS]
synonym: "neoplasm" NARROW []
synonym: "neoplastic" NARROW []
synonym: "tumorigenesis" NARROW []
synonym: "tumorigenic" NARROW []
is_a: FBcv:0000357 ! abnormal size
is_a: FBcv:0000362 ! increased cell number

[Term]
id: FBcv:0000724
name: hypoplasia
namespace: phenotypic_class
def: "Phenotype that is a reduction in size of an organ or tissue compared to wild-type due to reduced numbers of cells being produced during its development or growth." [FBC:DOS]
comment: This term should not be used where an organ or tissue is reduced in size due to the wasting away of existing cells.
is_a: FBcv:0000359 ! decreased cell number

[Term]
id: FBcv:0000725
name: abnormal oxidative stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to oxidative stress (GO:0006979). 'response to oxidative stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.'" [FBC:DOS, GOC:jl, PMID:12115731]
synonym: "oxidative stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000726
name: virgin female
namespace: sex_qualifier
def: "Expressed in virgin females." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in virgin females.
is_a: FBcv:0000334 ! female
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:10:32Z" xsd:dateTime

[Term]
id: FBcv:0000727
name: mated female
namespace: sex_qualifier
def: "Expressed in mated females." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in mated females.
is_a: FBcv:0000334 ! female
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:10:49Z" xsd:dateTime

[Term]
id: FBcv:0000728
name: virgin male
namespace: sex_qualifier
def: "Expressed in virgin males." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in virgin males.
is_a: FBcv:0000333 ! male
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:11:13Z" xsd:dateTime

[Term]
id: FBcv:0000729
name: mated male
namespace: sex_qualifier
def: "Expressed in mated males." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in mated females.
is_a: FBcv:0000333 ! male
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:11:21Z" xsd:dateTime

[Term]
id: FBcv:0000730
name: virgin female limited
namespace: sex_qualifier
def: "Expression is limited to virgin females." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000308 ! female limited
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:11:46Z" xsd:dateTime

[Term]
id: FBcv:0000731
name: mated female limited
namespace: sex_qualifier
def: "Expression is limited to mated females." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000308 ! female limited
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:11:59Z" xsd:dateTime

[Term]
id: FBcv:0000732
name: mated male limited
namespace: sex_qualifier
def: "Expression is limited to mated males." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000307 ! male limited
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:12:14Z" xsd:dateTime

[Term]
id: FBcv:0000733
name: virgin male limited
namespace: sex_qualifier
def: "Expression is limited to virgin males." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000307 ! male limited
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-04-21T01:13:00Z" xsd:dateTime

[Term]
id: FBcv:0000734
name: terminal phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of terminal regions of the embryo/larva: the acron, telson and immediately adjacent segments." [FBC:DOS]
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2011-09-13T02:31:53Z" xsd:dateTime

[Term]
id: FBcv:0000735
name: N-nitrosodiethylamine
namespace: origin_of_mutation
def: "A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom (from CHEBI)." [CHEBI:34873]
synonym: "mutation induced by N-nitrosodiethylamine exposure" EXACT []
synonym: "NDEA" RELATED [FlyBase:FBrf0139766]
is_a: CHEBI:34873 ! N-nitrosodiethylamine
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000736
name: heat sensitive amorphic allele
namespace: allele_class
def: "An allele that completely lacks function (i.e. whose gene productive is completely inactive) at high temperatures, but that retains at least some function at lower temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000739 ! temperature conditional amorphic allele
is_a: FBcv:0000746 ! heat sensitive loss of function allele
intersection_of: FBcv:0000688 ! amorphic allele
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:54:34Z" xsd:dateTime

[Term]
id: FBcv:0000737
name: temperature conditional amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function at some temperatures (restrictive temperatures) but not others (permissive temperatures) from the observation that addition of extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000288 ! amorphic allele - genetic evidence
is_a: FBcv:0000739 ! temperature conditional amorphic allele
intersection_of: FBcv:0000288 ! amorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000738
name: edited book
namespace: pub_type
def: "A publication that is not issued on a regular, ongoing basis containing separate articles or chapters (typically reviews) written by different authors on a single subject or related subjects, overseen by one or more editors." [FBC:SM]
is_a: FBcv:0000652 ! compendium
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-07-10T04:05:08Z" xsd:dateTime

[Term]
id: FBcv:0000739
name: temperature conditional amorphic allele
namespace: allele_class
def: "An allele that completely lacks function (i.e. whose gene productive is completely inactive) at some temperatures, but not others." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000688 ! amorphic allele
is_a: FBcv:0000745 ! temperature conditional loss of function allele
intersection_of: FBcv:0000688 ! amorphic allele
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:57:02Z" xsd:dateTime

[Term]
id: FBcv:0000740
name: cold sensitive amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000737 ! temperature conditional amorphic allele - genetic evidence
is_a: FBcv:0001003 ! cold sensitive amorphic allele
intersection_of: FBcv:0000288 ! amorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000741
name: heat sensitive amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000736 ! heat sensitive amorphic allele
is_a: FBcv:0000737 ! temperature conditional amorphic allele - genetic evidence
intersection_of: FBcv:0000288 ! amorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000742
name: cold sensitive amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures)." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000744 ! temperature conditional amorphic allele - molecular evidence
is_a: FBcv:0001003 ! cold sensitive amorphic allele
intersection_of: FBcv:0000689 ! amorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000743
name: heat sensitive amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures)." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000736 ! heat sensitive amorphic allele
is_a: FBcv:0000744 ! temperature conditional amorphic allele - molecular evidence
intersection_of: FBcv:0000689 ! amorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000744
name: temperature conditional amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function at some temperatures (restrictive temperatures) but not at others (permissive temperatures)." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000689 ! amorphic allele - molecular evidence
is_a: FBcv:0000739 ! temperature conditional amorphic allele
intersection_of: FBcv:0000689 ! amorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000745
name: temperature conditional loss of function allele
namespace: allele_class
def: "An allele that at some temperatures but not others either makes no functional gene product or makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000287 ! loss of function allele
intersection_of: FBcv:0000287 ! loss of function allele
intersection_of: conditionality FBcv:0000310 ! temperature conditional
relationship: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:57:02Z" xsd:dateTime

[Term]
id: FBcv:0000746
name: heat sensitive loss of function allele
namespace: allele_class
def: "An allele that at high temperatures but not low temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000745 ! temperature conditional loss of function allele
intersection_of: FBcv:0000287 ! loss of function allele
intersection_of: conditionality FBcv:0000311 ! heat sensitive
relationship: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:54:34Z" xsd:dateTime

[Term]
id: FBcv:0000747
name: cold sensitive loss of function allele
namespace: allele_class
def: "An allele that at low temperatures but not high temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000745 ! temperature conditional loss of function allele
intersection_of: FBcv:0000287 ! loss of function allele
intersection_of: conditionality FBcv:0000312 ! cold sensitive
relationship: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000748
name: temperature conditional gain of function allele
namespace: allele_class
def: "An allele that at some temperatures but not others, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000290 ! gain of function allele
intersection_of: FBcv:0000290 ! gain of function allele
intersection_of: conditionality FBcv:0000310 ! temperature conditional
relationship: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:57:02Z" xsd:dateTime

[Term]
id: FBcv:0000749
name: heat sensitive gain of function allele
namespace: allele_class
def: "An allele that at high temperatures but not low temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000748 ! temperature conditional gain of function allele
intersection_of: FBcv:0000290 ! gain of function allele
intersection_of: conditionality FBcv:0000311 ! heat sensitive
relationship: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:54:34Z" xsd:dateTime

[Term]
id: FBcv:0000750
name: cold sensitive gain of function allele
namespace: allele_class
def: "An allele that at low temperatures but not high temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000748 ! temperature conditional gain of function allele
intersection_of: FBcv:0000290 ! gain of function allele
intersection_of: conditionality FBcv:0000312 ! cold sensitive
relationship: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000751
name: temperature conditional hypomorphic allele
namespace: allele_class
def: "An allele that, at some temperatures but not others, makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000690 ! hypomorphic allele
is_a: FBcv:0000745 ! temperature conditional loss of function allele
intersection_of: FBcv:0000690 ! hypomorphic allele
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:57:02Z" xsd:dateTime

[Term]
id: FBcv:0000752
name: heat sensitive hypomorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is functionally equivalent to wild-type but which at high temperatures is present in a lesser amount or with lowered activity, and that retains normal levels of expression or activity at low temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000746 ! heat sensitive loss of function allele
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele
intersection_of: FBcv:0000690 ! hypomorphic allele
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:54:34Z" xsd:dateTime

[Term]
id: FBcv:0000753
name: cold sensitive hypomorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is functionally equivalent to wild-type but which at low temperatures is present in a lesser amount or with lowered activity, and that retains normal function at higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000747 ! cold sensitive loss of function allele
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele
intersection_of: FBcv:0000690 ! hypomorphic allele
intersection_of: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000754
name: temperature conditional hypomorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to have normal activity at some temperatures (permissive temperatures) but at other temperatures to make a gene product with normal function but in a lesser amount or with lowered activity (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy))." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000289 ! hypomorphic allele - genetic evidence
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele
intersection_of: FBcv:0000289 ! hypomorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000755
name: cold sensitive hypomorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to have normal activity at high temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at lower temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy))." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000753 ! cold sensitive hypomorphic allele
is_a: FBcv:0000754 ! temperature conditional hypomorphic allele - genetic evidence
intersection_of: FBcv:0000289 ! hypomorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000756
name: heat sensitive hypomorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to have normal activity at low temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at higher temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy))." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000752 ! heat sensitive hypomorphic allele
is_a: FBcv:0000754 ! temperature conditional hypomorphic allele - genetic evidence
intersection_of: FBcv:0000289 ! hypomorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000757
name: temperature conditional hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a normal gene product in normal amounts at some temperatures, but at other temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000691 ! hypomorphic allele - molecular evidence
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele
intersection_of: FBcv:0000691 ! hypomorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000758
name: cold sensitive hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a normal gene product in normal amounts at high temperatures, but at lower temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000753 ! cold sensitive hypomorphic allele
is_a: FBcv:0000757 ! temperature conditional hypomorphic allele - molecular evidence
intersection_of: FBcv:0000691 ! hypomorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000759
name: heat sensitive hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a normal gene product in normal amounts at low temperatures, but at higher temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000752 ! heat sensitive hypomorphic allele
is_a: FBcv:0000757 ! temperature conditional hypomorphic allele - molecular evidence
intersection_of: FBcv:0000691 ! hypomorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000760
name: temperature conditional antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at some temperatures, but not others." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000695 ! antimorphic allele
is_a: FBcv:0000748 ! temperature conditional gain of function allele
intersection_of: FBcv:0000695 ! antimorphic allele
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:57:02Z" xsd:dateTime

[Term]
id: FBcv:0000761
name: heat sensitive antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at high temperatures, but not at lower temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000749 ! heat sensitive gain of function allele
is_a: FBcv:0000760 ! temperature conditional antimorphic allele
intersection_of: FBcv:0000695 ! antimorphic allele
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:54:34Z" xsd:dateTime

[Term]
id: FBcv:0000762
name: cold sensitive antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at cold temperatures, but not at higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000750 ! cold sensitive gain of function allele
is_a: FBcv:0000760 ! temperature conditional antimorphic allele
intersection_of: FBcv:0000695 ! antimorphic allele
intersection_of: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000763
name: temperature conditional antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make a gene product that is antagonistic to the wild-type gene product at some temperatures (restrictive temperatures) but not at others (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000292 ! antimorphic allele - genetic evidence
is_a: FBcv:0000760 ! temperature conditional antimorphic allele
intersection_of: FBcv:0000292 ! antimorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000764
name: cold sensitive antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make a gene product that is antagonistic to the wild-type gene product at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000762 ! cold sensitive antimorphic allele
is_a: FBcv:0000763 ! temperature conditional antimorphic allele - genetic evidence
intersection_of: FBcv:0000292 ! antimorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000765
name: heat sensitive antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make a gene product that is antagonistic to the wild-type gene product at high temperatures (restrictive temperatures) but not at lower temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000761 ! heat sensitive antimorphic allele
is_a: FBcv:0000763 ! temperature conditional antimorphic allele - genetic evidence
intersection_of: FBcv:0000292 ! antimorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000766
name: temperature conditional antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at some temperatures but not others." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000694 ! antimorphic allele - molecular evidence
is_a: FBcv:0000760 ! temperature conditional antimorphic allele
intersection_of: FBcv:0000694 ! antimorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000767
name: cold sensitive antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at low temperatures but not higher temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000762 ! cold sensitive antimorphic allele
is_a: FBcv:0000766 ! temperature conditional antimorphic allele - molecular evidence
intersection_of: FBcv:0000694 ! antimorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000768
name: heat sensitive antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at high temperatures but not lower temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000761 ! heat sensitive antimorphic allele
is_a: FBcv:0000766 ! temperature conditional antimorphic allele - molecular evidence
intersection_of: FBcv:0000694 ! antimorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000769
name: temperature conditional neomorphic allele
namespace: allele_class
def: "An allele that, at some temperatures but not others, makes a gene product with a novel function or expression pattern compared to wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000697 ! neomorphic allele
is_a: FBcv:0000748 ! temperature conditional gain of function allele
intersection_of: FBcv:0000697 ! neomorphic allele
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:57:02Z" xsd:dateTime

[Term]
id: FBcv:0000770
name: heat sensitive neomorphic allele
namespace: allele_class
def: "An allele that, at some high temperatures but not lower temperatures, makes a gene product with a novel function or expression pattern compared to wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000749 ! heat sensitive gain of function allele
is_a: FBcv:0000769 ! temperature conditional neomorphic allele
intersection_of: FBcv:0000697 ! neomorphic allele
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:54:34Z" xsd:dateTime

[Term]
id: FBcv:0000771
name: cold sensitive neomorphic allele
namespace: allele_class
def: "An allele that, at some low temperatures but not higher temperatures, makes a gene product at with a novel function or expression pattern compared to wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000750 ! cold sensitive gain of function allele
is_a: FBcv:0000769 ! temperature conditional neomorphic allele
intersection_of: FBcv:0000697 ! neomorphic allele
intersection_of: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000772
name: temperature conditional neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some temperatures (non-permissive temperatures) but not others (permissive temperatures) based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000291 ! neomorphic allele - genetic evidence
is_a: FBcv:0000769 ! temperature conditional neomorphic allele
intersection_of: FBcv:0000291 ! neomorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000773
name: cold sensitive neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000771 ! cold sensitive neomorphic allele
is_a: FBcv:0000772 ! temperature conditional neomorphic allele - genetic evidence
intersection_of: FBcv:0000291 ! neomorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000774
name: heat sensitive neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000770 ! heat sensitive neomorphic allele
is_a: FBcv:0000772 ! temperature conditional neomorphic allele - genetic evidence
intersection_of: FBcv:0000291 ! neomorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000775
name: temperature conditional neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at some temperatures but not others." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000692 ! neomorphic allele - molecular evidence
is_a: FBcv:0000769 ! temperature conditional neomorphic allele
intersection_of: FBcv:0000692 ! neomorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000776
name: cold sensitive neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at low temperatures but not higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000771 ! cold sensitive neomorphic allele
is_a: FBcv:0000775 ! temperature conditional neomorphic allele - molecular evidence
intersection_of: FBcv:0000692 ! neomorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000777
name: heat sensitive neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at high temperatures but not lower temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000770 ! heat sensitive neomorphic allele
is_a: FBcv:0000775 ! temperature conditional neomorphic allele - molecular evidence
intersection_of: FBcv:0000692 ! neomorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000778
name: temperature conditional hypermorphic allele
namespace: allele_class
def: "An allele that, at some temperatures but not others, makes a gene product with normal function but at higher levels or with higher activity than in wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000696 ! hypermorphic allele
is_a: FBcv:0000748 ! temperature conditional gain of function allele
intersection_of: FBcv:0000696 ! hypermorphic allele
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:57:02Z" xsd:dateTime

[Term]
id: FBcv:0000779
name: heat sensitive hypermorphic allele
namespace: allele_class
def: "An allele that, at high temperatures but not lower temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000749 ! heat sensitive gain of function allele
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele
intersection_of: FBcv:0000696 ! hypermorphic allele
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:54:34Z" xsd:dateTime

[Term]
id: FBcv:0000780
name: cold sensitive hypermorphic allele
namespace: allele_class
def: "An allele that, at low temperatures but not higher temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type.." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000750 ! cold sensitive gain of function allele
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele
intersection_of: FBcv:0000696 ! hypermorphic allele
intersection_of: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000781
name: temperature conditional hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at some temperatures (non-permissive temperatures) but not others (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000293 ! hypermorphic allele - genetic evidence
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele
intersection_of: FBcv:0000293 ! hypermorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000782
name: cold sensitive hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000780 ! cold sensitive hypermorphic allele
is_a: FBcv:0000781 ! temperature conditional hypermorphic allele - genetic evidence
intersection_of: FBcv:0000293 ! hypermorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000783
name: heat sensitive hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000779 ! heat sensitive hypermorphic allele
is_a: FBcv:0000781 ! temperature conditional hypermorphic allele - genetic evidence
intersection_of: FBcv:0000293 ! hypermorphic allele - genetic evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000784
name: temperature conditional hypermorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at some temperatures but not others." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000693 ! hypermorphic allele - molecular evidence
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele
intersection_of: FBcv:0000693 ! hypermorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000310 ! temperature conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:55:17Z" xsd:dateTime

[Term]
id: FBcv:0000785
name: cold sensitive hypermorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at low temperatures but not higher temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000780 ! cold sensitive hypermorphic allele
is_a: FBcv:0000784 ! temperature conditional hypermorphic allele - molecular evidence
intersection_of: FBcv:0000693 ! hypermorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000312 ! cold sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:58:31Z" xsd:dateTime

[Term]
id: FBcv:0000786
name: heat sensitive hypermorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at high temperatures but not lower temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000779 ! heat sensitive hypermorphic allele
is_a: FBcv:0000784 ! temperature conditional hypermorphic allele - molecular evidence
intersection_of: FBcv:0000693 ! hypermorphic allele - molecular evidence
intersection_of: conditionality FBcv:0000311 ! heat sensitive
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-03-22T03:59:43Z" xsd:dateTime

[Term]
id: FBcv:0000787
name: journal
namespace: pub_type
def: "A publication issued on a regular, ongoing basis containing separate research articles and other writings such as reviews, comments and conference reports." [FBC:SM, MeSH:D020492]
synonym: "Periodicals" RELATED [MeSH:D020492]
xref: MeSH:D020492
is_a: FBcv:0000652 ! compendium
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-07-10T04:08:06Z" xsd:dateTime

[Term]
id: FBcv:0000788
name: newspaper article
namespace: pub_type
def: "A work consisting of a news item appearing in a general-interest newspaper or other general news periodical, containing information of current and timely interest in the field of medicine or science." [FBC:SM, MeSH:D018431]
xref: MeSH:D018431
is_a: FBcv:0000189 ! publication class
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-07-10T04:17:34Z" xsd:dateTime

[Term]
id: FBcv:0000789
name: sequence record
namespace: pub_type
def: "A record of a nucleotide or protein sequence in some standard format." [FBC:SM]
is_a: FBcv:0000189 ! publication class
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-07-10T05:42:47Z" xsd:dateTime

[Term]
id: FBcv:0000790
name: database
namespace: pub_type
def: "Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means." [FBC:SM, MeSH:D019991]
xref: MeSH:D019991
is_a: FBcv:0000189 ! publication class
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-07-13T02:06:57Z" xsd:dateTime

[Term]
id: FBcv:0000791
name: decreased speed of aging
namespace: phenotypic_class
def: "A phenotype in which the aging process is slower than in wild-type." [FBC:DOC]
synonym: "delayed aging" RELATED []
synonym: "reduced speed of aging" EXACT []
is_a: FBcv:0000384 ! abnormal aging

[Term]
id: FBcv:0000792
name: increased speed of aging
namespace: phenotypic_class
def: "A phenotype in which the aging process is accelerated compared to wild-type." [FBC:DOC]
synonym: "premature aging" RELATED []
is_a: FBcv:0000384 ! abnormal aging

[Term]
id: FBcv:0000793
name: progressive
namespace: temporal_qualifier
def: "A phenotype that becomes more severe with age." [FBC:DOS]
is_a: FBcv:0000176 ! temporal qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2012-10-10T12:02:35Z" xsd:dateTime

[Term]
id: FBcv:0000797
name: cell autonomy qualifier
namespace: genotype_to_phenotype_relation
def: "Cell autonomy statements describe the cellular focus of mutant phenotype, generally revealed by genetic mosaic analysis, in terms of whether the mutant has its phenotypic effect limited to, or not limited to, cells of the mutant genotype." [FBC:rd]
subset: do_not_annotate
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000799
name: obsolete gene descriptor
is_obsolete: true

[Term]
id: FBcv:0000801
name: obsolete polymorphism assay
is_obsolete: true

[Term]
id: FBcv:0000803
name: obsolete RFLP
synonym: "restriction fragment length polymorphism" RELATED []
is_obsolete: true

[Term]
id: FBcv:0000805
name: obsolete DNA sequence variant
is_obsolete: true

[Term]
id: FBcv:0000807
name: allele descriptor
def: "Descriptor that relates to aspects of an allele." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0000809
name: phenotype qualifier
def: "Qualifier that describes an observable phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000811
name: qualitative qualifier
def: "Qualifier that describes a particular quality of an observable phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000812
name: clone of cells
namespace: clone_qualifier
def: "A clone of cells that share a genotype." [FBC:DOS]
synonym: "clone qualifier" RELATED []
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000813
name: nitrogen mustard
namespace: origin_of_mutation
def: "Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR (from CHEBI)." [CHEBI:37598]
synonym: "2-chloro-N-(2-chloroethyl)-N-methylethanamine" RELATED []
synonym: "CB1414" RELATED []
synonym: "HN2" RELATED []
synonym: "mechlorethamine" RELATED []
synonym: "mutation induced by nitrogen mustard exposure" EXACT []
is_a: CHEBI:37598 ! nitrogen mustard
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000814
name: 1,4-dimethanesulfonoxybutane
namespace: origin_of_mutation
def: "A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant (from CHEBI)." [CHEBI:28901]
synonym: "busulfan" RELATED [CHEBI:28901]
synonym: "CB2041" RELATED []
synonym: "mutation induced by 1,4-dimethanesulfonoxybutane exposure" EXACT []
synonym: "mutation induced by busulfan exposure" EXACT []
is_a: CHEBI:28901 ! busulfan
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000815
name: p-N,N-di-(2-chloroethyl)aminophenylbutyric acid
namespace: origin_of_mutation
def: "A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia (from CHEBI)." [CHEBI:28830]
synonym: "CB1348" RELATED []
synonym: "chlorambucil" EXACT [CHEBI:28830]
synonym: "mutation induced by chlorambucil exposure" EXACT []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)aminophenylbutyric acid exposure" EXACT []
is_a: CHEBI:28830 ! chlorambucil
is_a: FBcv:0000813 ! nitrogen mustard

[Term]
id: FBcv:0001003
name: cold sensitive amorphic allele
def: "An allele that completely lacks function (i.e. whose gene productive is completely inactive) at low temperatures, but that retains at least some function at higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000739 ! temperature conditional amorphic allele
is_a: FBcv:0000747 ! cold sensitive loss of function allele
intersection_of: FBcv:0000688 ! amorphic allele
intersection_of: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0001315
name: beta-estradiol conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of beta-estradiol (CHEBI:16469)." [FBC:DOS]
synonym: "conditional beta-estradiol" EXACT []
is_a: FBcv:0000313 ! drug conditional

[Term]
id: FBcv:0001324
name: obsolete endocytosis defective
namespace: phenotypic_class
def: "Phenotype that is a defect in endocytosis (GO:0006897). 'endocytosis' is defined as: 'A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.'" [FBC:DOS]
comment: Obsoleted as this is phenotype is too molecular to be captured by FlyBase phenotype curation and will be captured by GO curation [FBC:CP].
synonym: "abnormal endocytosis" EXACT []
is_obsolete: true

[Term]
id: FBcv:0001325
name: obsolete exocytosis defective
namespace: phenotypic_class
def: "Phenotype that is a defect in exocytosis (GO:0006887). 'exocytosis' is defined as: 'A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.'" []
comment: Obsoleted as this is phenotype is too molecular to be captured by FlyBase phenotype curation and will be captured by GO curation [FBC:CP].
synonym: "abnormal exocytosis" EXACT []
is_obsolete: true

[Term]
id: FBcv:0001347
name: phenotype
namespace: phenotypic_class
def: "Any abnormality in or loss of some anatomical structure or biological process compared to wild-type." [FBC:DOS]
comment: The subclasses of this term classify Drosophila phenotypes into different common categories. They have been chosen by FlyBase to reflect phenotype terms most often reported by Drosophila researchers in the published literature.
subset: do_not_annotate
synonym: "phenotypic class" EXACT []
is_a: FBcv:0000347 ! phenotypic class

[Term]
id: FBcv:0001500
name: minos activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by Minos, a DNA transposable element. The minos element is 1.4 kilobases in length with 254 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of 2 base pairs upon insertion. Mobilization is induced by the activity of the minos transposase." [FBC:DOS, FlyBase:FBrf0202435]
synonym: "mutation induced by minos activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0002000
name: lethal - all die before end of P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages prior to eclosion from the pupal case (the end of the P-stage)." [FBC:DOS]
comment: As the P-Stage and the 'pharate adult stage' have the same end, there is no need for a separate term for 'lethal - all die before end of pharate adult stage.
subset: lethal_phase
synonym: "lethal - all die before end of pharate adult stage" EXACT []
synonym: "pupal lethal" BROAD []
is_a: FBcv:0000351 ! lethal

[Term]
id: FBcv:0002001
name: lethal - all die before end of first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002003 ! lethal - all die before end of second instar larval stage

[Term]
id: FBcv:0002002
name: lethal - all die before end of larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the larval stage." [FBC:DOS]
comment: As the larval stage and third instar larval stage have the same end, there is no need for a separate term for 'lethal - all die before end of third instar larval stage'.
subset: lethal_phase
synonym: "larval lethal" BROAD []
synonym: "lethal - all die before end of third instar larval stage" EXACT []
is_a: FBcv:0002026 ! lethal - all die before end of prepupal stage

[Term]
id: FBcv:0002003
name: lethal - all die before end of second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002002 ! lethal - all die before end of larval stage

[Term]
id: FBcv:0002004
name: increased mortality
namespace: phenotypic_class
def: "A phenotype that is an increase in the rate of death in a population at any stage of life (during development or adulthood), over the rate seen in a wild type control population." [FBC:DOS]
subset: fbcvsubset_mgiribbons
subset: lethal_phase
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0002005
name: lethal - all die during P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the P-stage." [FBC:DOS]
subset: lethal_phase
synonym: "pupal lethal" BROAD []
is_a: FBcv:0002000 ! lethal - all die before end of P-stage
is_a: FBcv:0002010 ! majority die during P-stage

[Term]
id: FBcv:0002006
name: lethal - all die during first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002001 ! lethal - all die before end of first instar larval stage
is_a: FBcv:0002007 ! lethal - all die during larval stage
is_a: FBcv:0002011 ! majority die during first instar larval stage

[Term]
id: FBcv:0002007
name: lethal - all die during larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the larval stage." [FBC:DOS]
subset: lethal_phase
synonym: "larval lethal" BROAD []
is_a: FBcv:0002002 ! lethal - all die before end of larval stage
is_a: FBcv:0002012 ! majority die during larval stage

[Term]
id: FBcv:0002008
name: lethal - all die during second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002003 ! lethal - all die before end of second instar larval stage
is_a: FBcv:0002007 ! lethal - all die during larval stage
is_a: FBcv:0002013 ! majority die during second instar larval stage

[Term]
id: FBcv:0002009
name: lethal - all die during third instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the third instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002007 ! lethal - all die during larval stage
is_a: FBcv:0002014 ! majority die during third instar larval stage

[Term]
id: FBcv:0002010
name: majority die during P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the P-stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002011
name: majority die during first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002012 ! majority die during larval stage
is_a: FBcv:0002021 ! some die during first instar larval stage

[Term]
id: FBcv:0002012
name: majority die during larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002013
name: majority die during second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002012 ! majority die during larval stage
is_a: FBcv:0002022 ! some die during second instar larval stage

[Term]
id: FBcv:0002014
name: majority die during third instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the third instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002012 ! majority die during larval stage
is_a: FBcv:0002024 ! some die during third instar larval stage

[Term]
id: FBcv:0002015
name: partially lethal
namespace: phenotypic_class
def: "A phenotype of a population that is the death of some significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002019
name: increased mortality during development
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002004 ! increased mortality

[Term]
id: FBcv:0002020
name: some die during P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the P-stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002021
name: some die during first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002022
name: some die during second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002023
name: some die during larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002024
name: some die during third instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the third instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002025
name: lethal - all die during pharate adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the pharate adult stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002005 ! lethal - all die during P-stage
is_a: FBcv:0002036 ! majority die during pharate adult stage

[Term]
id: FBcv:0002026
name: lethal - all die before end of prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002027 ! lethal - all die before end of pupal stage

[Term]
id: FBcv:0002027
name: lethal - all die before end of pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the pupal stage." [FBC:DOS]
subset: lethal_phase
synonym: "pupal lethal" BROAD []
is_a: FBcv:0002000 ! lethal - all die before end of P-stage

[Term]
id: FBcv:0002030
name: lethal - all die during pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the pupal stage." [FBC:DOS]
subset: lethal_phase
synonym: "pupal lethal" BROAD []
is_a: FBcv:0002005 ! lethal - all die during P-stage
is_a: FBcv:0002027 ! lethal - all die before end of pupal stage
is_a: FBcv:0002034 ! majority die during pupal stage

[Term]
id: FBcv:0002031
name: lethal - all die during prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002005 ! lethal - all die during P-stage
is_a: FBcv:0002026 ! lethal - all die before end of prepupal stage
is_a: FBcv:0002035 ! majority die during prepupal stage

[Term]
id: FBcv:0002032
name: obsolete lethal - all die before end of embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the embryonic stage." [FBC:DOS]
comment: Obsoleted due to equivalence with FBcv:0002033 'lethal - all die during embryonic stage'.
is_obsolete: true
replaced_by: FBcv:0002033

[Term]
id: FBcv:0002033
name: lethal - all die during embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the embryonic stage." [FBC:DOS]
subset: lethal_phase
synonym: "embryonic lethal" EXACT []
is_a: FBcv:0002001 ! lethal - all die before end of first instar larval stage
is_a: FBcv:0002037 ! majority die during embryonic stage

[Term]
id: FBcv:0002034
name: majority die during pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the pupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002010 ! majority die during P-stage
is_a: FBcv:0002039 ! some die during pupal stage

[Term]
id: FBcv:0002035
name: majority die during prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002010 ! majority die during P-stage
is_a: FBcv:0002040 ! some die during prepupal stage

[Term]
id: FBcv:0002036
name: majority die during pharate adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the pharate adult stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002010 ! majority die during P-stage
is_a: FBcv:0002038 ! some die during pharate adult stage

[Term]
id: FBcv:0002037
name: majority die during embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the embryonic stage." [FBC:DOS]
comment: This term is agnostic about whether any survive to adulthood.
subset: lethal_phase
is_a: FBcv:0002041 ! some die during embryonic stage

[Term]
id: FBcv:0002038
name: some die during pharate adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the pharate adult stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002039
name: some die during pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the pupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002040
name: some die during prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002041
name: some die during embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the embryonic stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002042
name: lethal - all die during immature adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012))." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0000351 ! lethal
is_a: FBcv:0002050 ! majority die during immature adult stage

[Term]
id: FBcv:0002050
name: majority die during immature adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012))." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002051 ! some die during immature adult stage

[Term]
id: FBcv:0002051
name: some die during immature adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of some significant number of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012))." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0003000
name: disease qualifier
namespace: disease_qualifier
def: "Qualifier that describes aspects of genetic models of disease." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003001
name: ameliorates
namespace: disease_qualifier
def: "Makes a condition better." [FBC:ST]
comment: The 'ameliorates' term is used in FlyBase disease annotation when an allele interacts to remove or reduce the severity of the disease phenotype associated with a given disease model (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003002
name: DOES NOT ameliorate
namespace: disease_qualifier
def: "Contrary to expectation, does not make a condition better." [FBC:ST]
comment: The 'DOES NOT ameliorate' term is used in FlyBase disease annotation when an allele is expected to remove or reduce the severity of the disease phenotype associated with a given disease model but fails to do so.
is_a: FBcv:0003000 ! disease qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003003
name: DOES NOT exacerbate
namespace: disease_qualifier
def: "Contrary to expectation, does not make a condition worse." [FBC:ST]
comment: The 'DOES NOT exacerbate' term is used in FlyBase disease annotation when an allele is expected to makes the disease phenotype associated with a given disease model more severe but fails to do so (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003004
name: DOES NOT model
namespace: disease_qualifier
def: "Contrary to expectation, characteristics associated with a given condition are not recapitulated in a different system." [FBC:ST]
comment: The 'DOES NOT model' term is used in FlyBase disease annotation when an allele is expected to recapitulate one or more aspects of a particular human disease phenotype in Drosophila but fails to do so (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003005
name: exacerbates
namespace: disease_qualifier
def: "Makes a condition worse." [FBC:ST]
comment: The 'exacerbates' term is used in FlyBase disease annotation when an allele interacts to make the disease phenotype associated with a given disease model more severe (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003006
name: model of
namespace: disease_qualifier
def: "Characteristics associated with a given condition recapitulated in a different system." [FBC:ST]
comment: The 'model of' term is used in FlyBase disease annotation when alleles (typically of fly or human genes) recapitulate one or more aspect of a human disease phenotype in Drosophila (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003007
name: site specific cleavage
namespace: origin_of_mutation
def: "Sequence change induced by a cleavage event that is caused by an endonuclease that recognizes and cleaves specific sequences in double stranded DNA causing double-strand breaks (DSB)." [FlyBase:FBrf0202435]
synonym: "change induced by site specific cleavage" EXACT []
is_a: FBcv:0000452 ! origin of mutation
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003008
name: CRISPR/Cas9
namespace: origin_of_mutation
def: "Sequence change caused by a cleavage of a specific DNA sequence induced by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 nuclease system. This system relies on the transcription of a chimeric guide RNA (gRNA) which directs the Cas9 endonuclease to a specified DNA sequence through basepairing to 20 nucleotide CRISPR target sites. These sites are located next to a 3 nucleotide protospacer adjacent motif (PAM) required for DNA cleavage." [FlyBase:FBrf0222128, FlyBase:FBrf0222292, FlyBase:FBrf0222617, UniProt:Q99ZW2]
synonym: "change induced by CRISPR/Cas9 endonuclease cleavage" EXACT []
synonym: "CRISPR/Cas9 endonuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003009
name: TALEN
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of specific DNA sequences by transcription activator-like effector nucleases (TALENs). TALEN proteins comprise a DNA binding domain fused to the catalytic domain of the FokI endonuclease. The DNA binding domain contains a repetitive region within the middle of the protein, consisting of tandem repeats of 34 amino acid segments, with each of these segments recognizing a single base pair. The specificity of the binding is determined by two hypervariable amino acids in positions 12 and 13 (repeat-variable diresidues). Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of TALENs which bind to adjacent sequences separated by a spacer region, allowing dimerization and promoting cleavage." [PMID:10954606, PMID:20660643]
synonym: "change induced by TALE endonuclease cleavage" EXACT []
synonym: "TALE endonuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003010
name: phiC31 integrase
namespace: origin_of_mutation
def: "Sequence change caused by a site specific recombination catalyzed by the serine recombinase phiC31 integrase that recognizes a minimal high-efficiency attP recognition site of 39 base pairs and a minimal high-efficiency attB recognition site of 34 base pairs. The attP and attB sites contain imperfect inverted repeats flanking a short recombination core (TTG) that provides directionality." [FlyBase:FBrf0174693, FlyBase:FBrf0201927, UniProt:Q9T221]
synonym: "change induced by phiC31 integrase recombination" EXACT []
is_a: FBcv:0000478 ! site specific recombination
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-27T11:07:29Z" xsd:dateTime

[Term]
id: FBcv:0003011
name: group descriptor
namespace: group_descriptor
def: "Descriptor that relates aspects of the grouping of genes or gene products." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003012
name: gene or gene product group
namespace: group_descriptor
def: "Genes or gene products that are acknowledged to form a natural biological group." [FBC:SM]
is_a: FBcv:0003011 ! group descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003013
name: gene array group
namespace: group_descriptor
def: "Two or more genes contiguously arranged where the individual genes are either identical in sequence, or essentially so (SO:0005851)." [FBC:SM, SO:ma]
is_a: FBcv:0003012 ! gene or gene product group
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003014
name: functional group
namespace: group_descriptor
def: "Genes whose products share a common biological and/or molecular function." [FBC:SM]
is_a: FBcv:0003012 ! gene or gene product group
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003015
name: gene complex group
namespace: group_descriptor
def: "Genes with the same location on the chromosome and whose products have a similar function." [FBC:SM, http://www.sdbonline.org/fly/aignfam/ensplitc.htm]
is_a: FBcv:0003014 ! functional group
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003016
name: protein complex group
namespace: group_descriptor
def: "Genes whose protein products form a macromolecular complex (GO:0043234)." [FBC:SM, GOC:go_curators]
is_a: FBcv:0003014 ! functional group
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003017
name: pathway group
namespace: group_descriptor
def: "Genes whose products act in a specified signal transduction or metabolic pathway." [FBC:SM]
is_a: FBcv:0003014 ! functional group
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003018
name: process group
namespace: group_descriptor
def: "Genes whose products act in a specified biological process." [FBC:SM]
is_a: FBcv:0003014 ! functional group
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-03-28T15:23:42Z" xsd:dateTime

[Term]
id: FBcv:0003019
name: I-element activity
namespace: origin_of_mutation
def: "Mutation caused by the transposable activity caused by the I-element, a non-LTR retrotransposon. The I-element is 5371 base pairs long. Mobilization is induced by the activity of the I-element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by I-element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-09-16T13:30:48Z" xsd:dateTime

[Term]
id: FBcv:0003020
name: Stalker element activity
namespace: origin_of_mutation
def: "Mutation caused by the transposable activity caused by the Stalker element, a LTR retrotransposon. Mobilization is induced by the activity of the stalker element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by Stalker element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2014-09-16T13:30:48Z" xsd:dateTime

[Term]
id: FBcv:0003021
name: dataset descriptor
def: "Term that describes a dataset." [FBC:GD]
is_a: FBcv:0000013 ! descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003022
name: dataset entity type
namespace: dataset_entity_type
def: "Term that specifies the dataset component type." [FBC:GD]
is_a: FBcv:0003021 ! dataset descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003023
name: project
namespace: dataset_entity_type
def: "A set of biological data from a single study. Corresponds to the NCBI bioproject, GEO series or SRA study." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003024
name: biosample
namespace: dataset_entity_type
def: "Biological source material characterized by an experiment." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003025
name: assay
namespace: dataset_entity_type
def: "Quantitative or qualitative assessment of biological source material to measure some attribute." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003026
name: result
namespace: dataset_entity_type
def: "Analysis of raw data generated by an assay(s) that makes some conclusion." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003027
name: reagent collection
namespace: dataset_entity_type
def: "A collection of material reagents." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003028
name: dataset data type
def: "The data type content of a dataset." [FBC:GD]
is_a: FBcv:0003021 ! dataset descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003029
name: project type
namespace: project_type
def: "The type of project as characterized its data content." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003030
name: umbrella project
namespace: project_type
def: "A project that groups together related sub-projects." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003031
name: genome
namespace: project_type
def: "A project that characterizes an organism's genome sequence." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003032
name: genome variation
namespace: project_type
def: "A project that characterizes the intraspecific variation of an organism's genome." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003033
name: genome binding
namespace: project_type
def: "A project that characterizes the occupancy profile of a factor that binds directly or indirectly to the genome." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003034
name: transcriptome
namespace: project_type
def: "A project that characterizes the set of transcribed RNA sequences expressed by the genome." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003035
name: proteome
namespace: project_type
def: "A project that characterizes the set of proteins expressed in an organism." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003036
name: interactome
namespace: project_type
def: "A project that characterizes the set of inter-molecular interactions in an organism." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003037
name: metabolome
namespace: project_type
def: "A project that characterizes the set of small molecules in an organism." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003038
name: phenotypic screen
namespace: project_type
def: "A project that searches for the genes responsible for a particular observable trait." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003039
name: chemical screen
namespace: project_type
def: "A project that searches for chemicals, natural or synthetic, that elicit some biological effect." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003040
name: gene model annotation
namespace: project_type
def: "A project that constructs models describing the set of transcripts and polypeptides encoded by some group of genes." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003041
name: phylogenetic analysis
namespace: project_type
def: "A project that reconstructs the evolutionary history of a group of genes or organisms." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003042
name: reagent
namespace: project_type
def: "A project that describes a large material resource that is accessible to the community." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003043
name: other
namespace: project_type
def: "A project type that is not described by other more specific terms." [FBC:GD]
is_a: FBcv:0003029 ! project type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003044
name: biosample type
namespace: biosample_type
def: "The type of biosample as characterized by its biological source material." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003045
name: whole organism
namespace: biosample_type
def: "A biosample that comprises the whole animal." [FBC:GD]
is_a: FBcv:0003044 ! biosample type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003046
name: tissue
namespace: biosample_type
def: "A biosample derived from a multicellular structure comprising similar cells with some specific function, typically isolated by dissection." [FBC:GD]
is_a: FBcv:0003044 ! biosample type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003047
name: isolated cells
namespace: biosample_type
def: "A biosample containing dissociated cells isolated from the organism, typically isolated by affinity capture or sorting methods." [FBC:GD]
is_a: FBcv:0003044 ! biosample type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003048
name: primary cell line
namespace: biosample_type
def: "A biosample consisting of cells that were isolated from animal tissue and cultured in vitro for a limited amount of time." [FBC:GD]
is_a: FBcv:0003044 ! biosample type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003049
name: immortalized cell line
namespace: biosample_type
def: "A biosample consisting of cells isolated from animal tissue that have acquired the ability to proliferate indefinitely." [FBC:GD]
is_a: FBcv:0003044 ! biosample type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003050
name: assay type
namespace: assay_type
def: "The type of assay as characterized by its data content." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003051
name: CAGE-Seq
namespace: assay_type
def: "An assay of 5' capped transcripts, using CAGE to biotinylate and isolate the 7-methylguanosine cap, with subsequent characterization by high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003052
name: ChIP-chip
namespace: assay_type
def: "A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and analysis of co-purifying DNA fragments using genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003053
name: ChIP-Seq
namespace: assay_type
def: "A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and high-throughput sequencing of co-purifying DNA fragments." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003054
name: CLiP-Seq
namespace: assay_type
def: "An RNA binding assay of some protein as characterized by cross-linking immunoprecipitation (CLiP) and high-throughput sequencing of co-purifying RNA fragments." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003055
name: DamID-chip
namespace: assay_type
def: "A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003056
name: DamID-Seq
namespace: assay_type
def: "A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003057
name: DNase-chip
namespace: assay_type
def: "An assay that characterizes the genome's DNase hypersensitivity using genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003058
name: DNase-Seq
namespace: assay_type
def: "An assay that characterizes the genome's DNase hypersensitivity using high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003059
name: FAIRE-Seq
namespace: assay_type
def: "An assay that characterizes transcriptional regulatory elements using formaldehyde-assisted isolation of regulatory elements (FAIRE) and high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003060
name: GRO-Seq
namespace: assay_type
def: "An assay that maps the genome-wide position, orientation and amount of transcriptionally engaged RNA polymerase by global run-on sequencing." [PMID:19056941]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003061
name: MNase-chip
namespace: assay_type
def: "An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003062
name: MNase-Seq
namespace: assay_type
def: "An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003063
name: RAMPAGE-Seq
namespace: assay_type
def: "An assay of 5'-capped transcripts using the orthogonal approaches of reverse transcriptase template-switching and cap-trapping, with subsequent characterization by high-throughput sequencing." [PMID:22936248]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003064
name: Repli-Seq
namespace: assay_type
def: "An assay mapping genomic replication patterns by labeling newly synthesized DNA in vivo with 5-bromo-2-deoxyuridine (BrdU), with subsequent affinity purification and characterization by high-throughput sequencing." [PMID:19966280]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003065
name: Ribo-Seq
namespace: assay_type
def: "Ribosome profiling, an assay in which mRNA fragments protected by ribosomes are isolated and characterized by high-throughput sequencing." [PMID:22056041]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003066
name: RIP-Seq
namespace: assay_type
def: "An assay in which a factor is immunoprecipitated and the associated RNA sequences are characterized by high-throughput sequencing." [PMID:21051541]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003067
name: RNA expression microarray
namespace: assay_type
def: "Measurement of global transcript abundance by hybridization of cDNA to an oligonucleotide array, in which the array contains a set of probes designed with complementarity to each annotated transcript." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003068
name: RNA-Seq
namespace: assay_type
def: "A quantitative method for mapping transcribed regions, in which complementary DNA fragments are subjected to high-throughput sequencing." [PMID:18451266]
xref: EFO:0008896
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003069
name: RNA tiling array
namespace: assay_type
def: "Measurement of transcribed regions across the genome by hybridization of cDNA to an oligonucleotide array, in which the genome is represented by oligonucleotides at regularly spaced intervals." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003070
name: short RNA-Seq
namespace: assay_type
def: "An assay characterizing of small RNA species 17-35 nt in size by high-throughput sequencing." [FBC:GD]
xref: EFO:0008947
is_a: FBcv:0003068 ! RNA-Seq
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003071
name: protein mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes of proteins and their post-translational modifications by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003072
name: lipid mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes lipids by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003073
name: carbohydrate mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes complex carbohydrates by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003074
name: metabolite mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes small metabolites by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003075
name: affinity purification and mass spectrometry
namespace: assay_type
def: "An assay that identifies the molecules that interact with a particular bait factor by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003076
name: two hybrid screen
namespace: assay_type
def: "An assay that tests proteins pairwise for interaction by fusing each to separate, complementary domains of some protein, usually a transcription factor. Upon interaction, the proximity of the complementary domains generates reporter activity." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003077
name: RNAi screen
namespace: assay_type
def: "An assay that uses a panel of RNA interference (RNAi) reagents to systematically knockdown a large set of genes, one at a time, to identify those that are involved in some biological process." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003078
name: deficiency screen
namespace: assay_type
def: "An assay that uses a panel of deficiencies to systematically delete large segments of the genome to identify those segments that are involved in some biological process." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003079
name: genetic screen
namespace: assay_type
def: "An assay that uses a large set of mutations to identify genes that are involved in some biological process." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003080
name: comparative genomic hybridization by array
namespace: assay_type
def: "An assay that characterizes copy number variation of the genome in a sample using genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003081
name: whole genome shotgun sequencing
namespace: assay_type
def: "An assay of genomic sequence that generates a large number of random genomic sequences, typically derived from paired-end sequencing of genomic fragments, that together give a complete (albeit scrambled) representation of the entire genome." [FBC:GD]
is_a: FBcv:0003050 ! assay type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003082
name: result type
namespace: result_type
def: "The type of result as characterized by its data content." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003083
name: genetic map
namespace: result_type
def: "A result that maps the relative position of genetic markers, where distances are measured by recombination frequency." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003084
name: physical map
namespace: result_type
def: "A result that maps the relative position of genes and other sequence landmarks." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003085
name: whole genome shotgun assembly
namespace: result_type
def: "A result in which a collection of whole genome shotgun sequences is combined to build successively larger contigs." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003086
name: genome assembly
namespace: result_type
def: "The result of reconstruction of the genome achieved by aligning and merging smaller fragments." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003087
name: reference genome assembly
namespace: result_type
def: "The result of extensive sequence alignment and merging to produce a genome assembly that serves as the current reference for a particular organism." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003088
name: gene expression profile
namespace: result_type
def: "A result that provides the expression values for all (or some subset) of genes in a given biological sample." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003089
name: RNA-seq profile
namespace: result_type
def: "A result that profiles expressed RNA-seq sequences along genome." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003090
name: genome binding profile
namespace: result_type
def: "A result that profiles the genome occupancy for some factor." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003091
name: mRNA translation profile
namespace: result_type
def: "A result of Ribo-seq analysis that profiles ribosome protected sequences along the genome." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003092
name: TSS identification
namespace: result_type
def: "An analysis that results in the identification of discrete transcription start site regions." [FBC:GD]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003093
name: poly(A) site identification
namespace: result_type
def: "An analysis that results in the identification of discrete polyadenylation sites." [FBC:GD]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003094
name: exon junction identification
namespace: result_type
def: "An analysis that results in the identification of discrete exon junctions." [FBC:GD]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003095
name: editing site identification
namespace: result_type
def: "An analysis that results in the identification of discrete A-to-I RNA editing sites." [FBC:GD]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003096
name: binding site identification
namespace: result_type
def: "An analysis that results in the identification of discrete DNA or RNA binding sites." [FBC:GD]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003097
name: differential gene expression analysis
namespace: result_type
def: "An analysis that results from the comparison of expression profiles for different conditions to identify genes that are regulated by those conditions." [FBC:GD]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003098
name: expression clustering
namespace: result_type
def: "The analysis of a gene expression profiles to define sets of genes that share similar expression characteristics." [FBC:GD]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003099
name: expression cluster
namespace: result_type
def: "A result that represents a set of genes that share similar expression characteristics across some set of conditions." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003100
name: gene list
namespace: result_type
def: "A result that represents a set of genes that have some shared characteristic." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003101
name: protein-protein interaction
namespace: result_type
def: "A result that represents a set of protein-protein interactions for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003102
name: RNA-protein interaction
namespace: result_type
def: "A result that represents a set of RNA-protein interactions for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003103
name: RNA-RNA interaction
namespace: result_type
def: "A result that represents a set of RNA-RNA interactions for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003104
name: metabolite profile
namespace: result_type
def: "A result that represents a set of small molecules identified for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003105
name: phenotypic profile
namespace: result_type
def: "A result that represents the range of phenotypes obtained for a set of genetic perturbations." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003106
name: genomic copy number profile
namespace: result_type
def: "A result that represents the copy number variation across the genome for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003107
name: liftover file
namespace: result_type
def: "A result that represents the mapping of coordinates between two different genome assemblies for a given species." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003108
name: analysis
namespace: result_type
def: "A result that is produced from the detailed examination of data to come to some conclusion." [FBC:GD]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003109
name: reagent collection type
namespace: reagent_collection_type
def: "The type of reagent collection as characterized by the material resources comprised by the collection." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003110
name: aberration stock collection
namespace: reagent_collection_type
def: "A collection of large chromosomal aberrations, available as fly stocks, which may include duplications, deletions, inversions or translocations." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003111
name: allele collection
namespace: reagent_collection_type
def: "A collection of alleles that are available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003112
name: cDNA library
namespace: reagent_collection_type
def: "A collection of cDNAs available as plasmids." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003113
name: construct collection
namespace: reagent_collection_type
def: "A collection of transgenic constructs that are available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003114
name: dsRNA amplicon collection
namespace: reagent_collection_type
def: "A collection of PCR products used for the synthesis of double-stranded RNA to induce RNA-interference." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003115
name: RNAi construct collection
namespace: reagent_collection_type
def: "A collection of transgenic constructs, available as fly stocks, designed to target gene knockdown by RNA-interference." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003116
name: genomic clone collection
namespace: reagent_collection_type
def: "A collection of genomic DNA clones available as plasmids. This may include BAC, YAC, fosmid, cosmid and P1 clone collections." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003117
name: fly strain collection
namespace: reagent_collection_type
def: "A collection of wild-type fly strains." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003118
name: transgenic insertion collection
namespace: reagent_collection_type
def: "A collection of transgenic construct insertions available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003119
name: TE insertion stock collection
namespace: reagent_collection_type
def: "A collection of transposable element insertions available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003120
name: microarray library
namespace: reagent_collection_type
def: "A collection of hybridization targets on a microarray." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003121
name: dataset attribute
def: "A descriptor that describes some aspect of a dataset." [FBC:GD]
is_a: FBcv:0003021 ! dataset descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003122
name: project attribute
namespace: project_attribute
def: "A descriptor that describes some aspect of a project." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003123
name: study design
namespace: project_attribute
def: "The aim of the project investigation, as defined by the key variables in the set of experiments." [FBC:GD]
is_a: FBcv:0003122 ! project attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003124
name: species study
namespace: project_attribute
def: "A project study design that aims to compare different species." [FBC:GD]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003125
name: strain study
namespace: project_attribute
def: "A project study design that aims to compare different wild-type strains for a given species." [FBC:GD]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003126
name: sex study
namespace: project_attribute
def: "A project study design that aims to characterize the biological mechanisms responsible for the development or maintenance of the sex-related properties of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003127
name: developmental stage study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms responsible for the control or maintenance of development." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003128
name: circadian rhythm study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms responsible for the control or maintenance of circadian rhythm." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003129
name: cell cycle study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms of the cell responsible for maintaining or controlling aspects of the cell cycle." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003130
name: tissue type study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms of intact or dissected tissues in order to understand their form or function." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003131
name: cell type study
namespace: project_attribute
def: "A project study design involving the use of cultured or extracted cells with an investigative focus of studying a cellular property." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003132
name: subcellular component study
namespace: project_attribute
def: "A project study design examining subcellular components of cells including organelles, the nucleus, or any other grouping of intra- or extracellular material." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003133
name: gene study
namespace: project_attribute
def: "A project study design in which the goal of the study is to examine properties of a specific gene or set of genes." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003134
name: biotic stimulus study
namespace: project_attribute
def: "A project study design investigating the effects of a biotic stimulus on some aspect of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003135
name: chemical stimulus study
namespace: project_attribute
def: "A project study design investigating the effects of a chemical stimulus on some aspect of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003136
name: physical stimulus study
namespace: project_attribute
def: "A project study design investigating the effects of a physical stimulus on some aspect of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003137
name: biosample attribute
namespace: biosample_attribute
def: "Characteristics pertaining to the growth conditions, treatments and tissue isolation methods used to generate and obtain a biosample." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003138
name: biosample scope
namespace: biosample_attribute
def: "The scope and purity of a biosample, ranging from single cell to environmental sample." [http://www.ncbi.nlm.nih.gov/books/NBK54364/]
is_a: FBcv:0003137 ! biosample attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003139
name: single cell sample
namespace: biosample_attribute
def: "A biosample that is derived from only a single cell." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003140
name: single individual sample
namespace: biosample_attribute
def: "A biosample that is derived from one individual." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003141
name: multi-individual sample
namespace: biosample_attribute
def: "A biosample that is derived from multiple individuals." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003142
name: multispecies sample
namespace: biosample_attribute
def: "A biosample that is derived from multiple species." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003143
name: environmental
namespace: biosample_attribute
def: "A biosample derived from an environmental sample for which the species content is unknown." [http://www.ncbi.nlm.nih.gov/books/NBK54364/]
is_a: FBcv:0003138 ! biosample scope
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003144
name: artificial
namespace: biosample_attribute
def: "A biosample that was synthesized in a laboratory." [http://www.ncbi.nlm.nih.gov/books/NBK54364/]
is_a: FBcv:0003138 ! biosample scope
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003145
name: wild caught
namespace: biosample_attribute
def: "A sample that originated from a wild caught population and is considered true wild type." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003146
name: growth condition
namespace: biosample_attribute
def: "Growth conditions and treatments used to culture the organism prior to biosample isolation." [FBC:GD]
is_a: FBcv:0003137 ! biosample attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003147
name: trait selection
namespace: biosample_attribute
def: "An inbred strain is subjected to artificial laboratory selection of some trait over the course of several generations." [FBC:GD]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003148
name: interspecific hybrid
namespace: biosample_attribute
def: "A sample that is derived from a controlled mating between individuals of two specific species." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003149
name: mated
namespace: biosample_attribute
def: "A sample in which the individuals have undergone mating." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003150
name: virgin
namespace: biosample_attribute
def: "A sample in which the individuals have not undergone mating." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003151
name: constant dark
namespace: biosample_attribute
def: "A sample that is maintained in conditions comparable to constant darkness." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003152
name: constant light
namespace: biosample_attribute
def: "A sample that is maintained in conditions comparable to constant light." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003153
name: light-dark cycle
namespace: biosample_attribute
def: "A sample that is maintained in conditions with a specific cycle that included exposure to both light and darkness." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003154
name: primary cell culture
namespace: biosample_attribute
def: "A sample that is derived from a primary cell culture." [FBC:CT]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003155
name: cell culture property
namespace: biosample_attribute
def: "Characteristics pertaining to the cell culture conditions used to generate the biosample." [FBC:GD]
is_a: FBcv:0003137 ! biosample attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003156
name: transiently transfected cell line
namespace: biosample_attribute
def: "A sample that contains a transfected agent which is not incorporated into the genome." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003157
name: stably transfected cell line
namespace: biosample_attribute
def: "A sample that contains a transfected agent which has been stably incorporated into the genome." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003158
name: log phase cells
namespace: biosample_attribute
def: "A sample that is derived from a population of cells undergoing a log phase of division." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003159
name: stationary phase cells
namespace: biosample_attribute
def: "A sample that is derived from a population of cells undergoing a stationary phase of division." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003160
name: cell cycle synchronized cells
namespace: biosample_attribute
def: "A sample that is derived from a population of cells undergoing cell cycle division in a synchronized manner." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003161
name: suspension culture
namespace: biosample_attribute
def: "The cells that are grown in liquid culture." [FBC:GD]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003162
name: adherent culture
namespace: biosample_attribute
def: "The cells that are grown on plates." [FBC:GD]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003163
name: culture supernatant
namespace: biosample_attribute
def: "The conditioned medium containing factors secreted by cultured cells that has been isolated." [FBC:GD]
is_a: FBcv:0003155 ! cell culture property
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003164
name: biosample method
namespace: biosample_attribute
def: "Methods pertaining to the experimental treatment or isolation of a biosample." [FBC:GD]
is_a: FBcv:0003137 ! biosample attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003165
name: gene perturbation
namespace: biosample_attribute
def: "A sample that has undergone a disruption to the activity of one of its genes." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003166
name: biotic treatment
namespace: biosample_attribute
def: "Treatment of an organism with a biological stimulus, such as an infectious or parasitic agent." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003167
name: chemical treatment
namespace: biosample_attribute
def: "A sample that has been exposed to one or more forms of chemical agent." [FBC:CT]
is_a: FBcv:0009014 ! biosample treatment method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003168
name: physical treatment
namespace: biosample_attribute
def: "A sample that has been exposed to changes in the physical environment including temperature, pressure and radiation." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003169
name: tissue dissection
namespace: biosample_attribute
def: "A sample that has been dissected from the tissue of a more complete organism." [FBC:CT]
is_a: FBcv:0009015 ! biosample preparation method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003170
name: cell isolation
namespace: biosample_attribute
def: "A single cell type that has been isolated by affinity purification or fluorescent cell sorting." [FBC:GD]
is_a: FBcv:0009015 ! biosample preparation method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003171
name: subcellular fractionation
namespace: biosample_attribute
def: "A sample that has undergone fractionation in order to isolate specific subcellular components for study." [FBC:CT]
is_a: FBcv:0009015 ! biosample preparation method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003172
name: cell ablation
namespace: biosample_attribute
def: "A sample in which specific cells within a tissue have been ablated by some method, such as targeted expression of a cell toxin, or laser ablation of fluorescently marked cells." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003173
name: targeted cell labeling
namespace: biosample_attribute
def: "A sample that has been labelled in a targeted, cell-specific manner." [FBC:CT]
is_a: FBcv:0009014 ! biosample treatment method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003174
name: neuronal activity perturbation
namespace: biosample_attribute
def: "Neuronal activity that has been perturbed using genetically controlled agents to activate or depress membrane potential." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003175
name: assay attribute
namespace: assay_attribute
def: "Some characteristic of an assay pertaining to the methods involved in processing the biological source material or generating the raw output data of the assay." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003176
name: assay material
namespace: assay_attribute
def: "A type of biomolecule that is isolated from a biosample and characterized by downstream steps in an assay." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003177
name: genomic DNA isolation
namespace: assay_attribute
def: "Material that is derived from isolation of genomic DNA." [FBC:CT]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003178
name: total RNA isolation
namespace: assay_attribute
def: "Material that is derived from isolation of the total RNA." [FBC:CT]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003179
name: poly(A) RNA isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of RNA containing a poly(A) tail." [FBC:CT]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003180
name: short RNA isolation
namespace: assay_attribute
def: "The isolation of small RNA species 17-35 nt in size." [FBC:GD]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003181
name: translated mRNA isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of translated messenger RNA." [FBC:CT]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003182
name: protein isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of proteins." [FBC:CT]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003183
name: chromatin isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of chromatin and its subcellular components and/or binding partners." [FBC:CT]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003184
name: RNA-protein isolation
namespace: assay_attribute
def: "Isolation of RNA-protein complexes." [FBC:GD]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003185
name: metabolite isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of metabolites." [FBC:CT]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003186
name: assay material depletion
namespace: assay_attribute
def: "The biosample that is depleted of specific biomolecule types before further processing." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003187
name: rRNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of ribosomal RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003188
name: ssRNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of single-stranded RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003189
name: dsRNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of double-stranded RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003190
name: unbound RNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of unbound RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003191
name: assay material selection
namespace: assay_attribute
def: "The biosample that is enriched for a specific biomolecule type for further processing." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003192
name: ChIP
namespace: assay_attribute
def: "Material that has been selected using Chromatin Immunoprecipitation, or ChIP." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003193
name: DamID
namespace: assay_attribute
def: "Material that has been selected using DNA Adenine Methyltransferase Identification, or DamID." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003194
name: FAIRE
namespace: assay_attribute
def: "Material that has been selected using formaldehyde-assisted isolation of Regulatory Elements or FAIRE." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003195
name: CAGE
namespace: assay_attribute
def: "Material that has been selected using Cap Analysis Gene Expression, in which the 7-methylguanosine cap at 5' transcript ends is biotinylated and affinity purified." [PMID:16489339]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003196
name: MNase
namespace: assay_attribute
def: "Chromatin that has been cleaved using micrococcal nuclease to cleave at linker DNA between nucleosomes." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003197
name: DNase
namespace: assay_attribute
def: "Material that has been selected from a sample treated by deoxyribonuclease." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003198
name: low salt chromatin extraction
namespace: assay_attribute
def: "Material that has been selected using a low salt chromatin extraction, typically 80mM." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003199
name: high salt chromatin extraction
namespace: assay_attribute
def: "Material that has been selected using a high salt chromatin extraction, typically 600mM." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003200
name: mononucleosomal DNA isolation
namespace: assay_attribute
def: "Mononucleosomal fragments, generated by micrococcal nuclease cleavage at linker DNA between nucleosomes, that have been isolated by gel electrophoresis." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003201
name: affinity purification
namespace: assay_attribute
def: "Material that has been selected using affinity purification." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003202
name: size fractionation
namespace: assay_attribute
def: "Material that has been selected using size fractionation." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003203
name: oligo-dT selection
namespace: assay_attribute
def: "Material that has been selected using short sequences of deoxy-thymine nucleotides to affinity purify RNA containing long polyA stretches." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003204
name: oligo-dT priming
namespace: assay_attribute
def: "Material that has been selected using short sequences of deoxy-thymine nucleotides to prime first strand cDNA synthesis by reverse transcriptase at long polyA stretches." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003205
name: random priming
namespace: assay_attribute
def: "Random oligomers that have been used to prime first strand cDNA synthesis by reverse transcriptase at random positions along transcripts." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003206
name: density sedimentation
namespace: assay_attribute
def: "Material that has been selected based on density via density sedimentation." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003207
name: nuclear run-on
namespace: assay_attribute
def: "Nucleotide analogs that are used to map the position and orientation of the RNA polymerase active site." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003208
name: assay method
namespace: assay_attribute
def: "A method used to characterize the biological molecules isolated from a biosample." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003209
name: Sanger sequencing
namespace: assay_attribute
def: "A method that uses Sanger sequencing for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003210
name: single molecule real time sequencing
namespace: assay_attribute
def: "A method that uses single molecule sequencing, by highly processive DNA polymerase to generate an extremely long single read on the order of several kilobases, for this assay." [FBC:GD]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003211
name: high-throughput sequencing
namespace: assay_attribute
def: "A method that uses high-throughput sequencing for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003212
name: 454 sequencing
namespace: assay_attribute
def: "A method that uses 454 sequencing, a form of high-throughput sequencing with 400-500 nt read length, for this assay." [FBC:CT]
is_a: FBcv:0003211 ! high-throughput sequencing
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003213
name: Illumina sequencing
namespace: assay_attribute
def: "A method that uses Illumina sequencing, a form of high-throughput sequencing, for this assay." [FBC:CT]
is_a: FBcv:0003211 ! high-throughput sequencing
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003214
name: Affymetrix Gene Expression Array 1
namespace: assay_attribute
def: "A method that uses an Affymetrix Gene Expression Array, version 1, for this assay." [FBC:CT, FBC:GD]
is_a: FBcv:0003240 ! expression array
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003215
name: Affymetrix Gene Expression Array 2
namespace: assay_attribute
def: "A method that uses an Affymetrix Gene Expression Array, version 2, for this assay." [FBC:CT]
is_a: FBcv:0003240 ! expression array
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003216
name: genomic tiling array
namespace: assay_attribute
def: "A method that uses a genomic tiling array, a subtype of microarray chip in which the genome is represented by oligonucleotides at regularly spaced intervals, for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003217
name: peptide array
namespace: assay_attribute
def: "A method that uses a peptide array, a subtype of microarray chip, for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003218
name: mass spectrometry
namespace: assay_attribute
def: "A method that uses mass spectrometry, an analytical technique for sorting ions based on mass, for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003219
name: two channel scanning
namespace: assay_attribute
def: "A method that uses two samples, one a control and the other an experimental sample, for this assay. The samples are labeled in different colors and hybridized to the same oligonucleotide array. Each sample is scanned using different excitation and emission parameters." [FBC:GD]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003220
name: single-end layout
namespace: assay_attribute
def: "A method that uses an RNA-seq assay in which only one end of the library fragment is sequenced." [FBC:GD]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003221
name: paired-end layout
namespace: assay_attribute
def: "A method that uses an RNA-seq assay in which both ends of the library fragment are sequenced to provide additional mapping constraints." [FBC:GD]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003222
name: result attribute
namespace: result_attribute
def: "Some characteristic of a result pertaining to the methods involved in analyzing the input data, or the content or format of the output data." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003223
name: stranded profile
namespace: result_attribute
def: "A genomic mapping profile that distinguishes forward and reverse strand distributions." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003224
name: unstranded profile
namespace: result_attribute
def: "A genomic mapping profile that does not distinguish between forward and reverse strand mapping." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003225
name: uniquely mapping read alignment
namespace: result_attribute
def: "An alignment of high-throughput sequences that includes only those reads mapping uniquely to the genome." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003226
name: multiply mapping read alignment
namespace: result_attribute
def: "An alignment of high-throughput sequences that includes reads mapping to multiple sites in the genome. Coverage values for a given sequence weighted equally across the multiple sites to which it maps." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003227
name: RPKM calculation
namespace: result_attribute
def: "A unit of expression (reads per kilobase per million reads) in which high-throughput sequencing reads mapping to a given feature are normalized both to the size of that feature and to the total number of reads in the sample." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003228
name: RPMM calculation
namespace: result_attribute
def: "A unit of expression (reads per million miRNA reads) in which high-throughput sequencing reads for a given miRNA are normalized against all reads mapping to all miRNA." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003229
name: RPM calculation
namespace: result_attribute
def: "A unit of expression (reads per million reads) in which high-throughput sequencing reads for a given type of feature are normalized against all reads mapping to all features of the same type." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003230
name: clone-based finishing
namespace: result_attribute
def: "Sequencing the full extent of selected large clones, typically by sub-cloning large inserts as smaller fragments, to improve the accuracy and completeness of an assembly." [FlyBase:FBrf0155823]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003231
name: restriction fingerprinting
namespace: result_attribute
def: "Mapping of restriction enzyme recognition sites to develop a physical map of a genome." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003232
name: sequence tagged site mapping
namespace: result_attribute
def: "Mapping of short (200-500 bp) sequence-tagged sites (STS) landmarks to develop a physical map of a genome." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003233
name: tiling path
namespace: result_attribute
def: "An ordered list of a minimal set of overlapping clones that provides complete coverage across an assembly." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003234
name: cytogenetic mapping
namespace: result_attribute
def: "Sequences that have been mapped to mitotic or polytene chromosomes to guide genome assembly." [FBC:GD]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003235
name: assembly level - chromosome
namespace: result_attribute
def: "There is sequence for one or more chromosomes. This could be a completely sequenced chromosome without gaps or a chromosome containing scaffolds or contigs with gaps between them. There may also be unplaced or unlocalized scaffolds." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003236
name: assembly level - scaffold
namespace: result_attribute
def: "Some sequence contigs have been connected across gaps to create scaffolds, but no scaffolds have been placed on chromosomes." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003237
name: genome representation - full
namespace: result_attribute
def: "The assembly represents the whole genome, though there may still be gaps." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003238
name: genome representation - partial
namespace: result_attribute
def: "The assembly represents only part of the organism's genome, because only a single chromosome was targeted, coverage is <1, or total length is less than half the average for other assemblies of the same species." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-02-24T19:19:21Z" xsd:dateTime

[Term]
id: FBcv:0003239
name: ZFN
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of specific DNA sequences by zinc finger nucleases (ZFNs). ZFN proteins comprise a DNA binding domain linked to the DNA cleavage domain of FokI endonuclease. The DNA binding domain is composed of three Cys2His2 zinc fingers, with each zinc finger contacting three consecutive base pairs of DNA. The specificity of the binding is determined by the sequence of the three-zinc finger DNA binding domain, which recognizes a 9 base pair sequence. Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of ZFNs which bind to sequences in close proximity, allowing dimerization and promoting cleavage." [PMID:10954606, PMID:12730594, PMID:8577732]
subset: camcur
synonym: "change induced by zinc finger nuclease-mediated cleavage" EXACT []
synonym: "zinc finger nuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-04-06T10:22:52Z" xsd:dateTime

[Term]
id: FBcv:0003240
name: expression array
namespace: assay_attribute
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-5948-3092
property_value: http://purl.org/dc/terms/date "2016-05-17T15:35:41Z" xsd:dateTime

[Term]
id: FBcv:0004000
name: abnormal visual perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of light stimulus (GO:0050953). 'sensory perception of light stimulus' is defined as: 'The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.'" [FBC:MMC, GOC:ai]
synonym: "visual perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0005000
name: Bxb1 integrase
namespace: origin_of_mutation
def: "Sequence change caused by a site specific recombination catalyzed by the serine recombinase Bxb1 integrase that recognizes a minimal high-efficiency attPX recognition site of 48 base pairs and a minimal high-efficiency attBX recognition site of 38 base pairs. The attPX and attBX sites share an 8bp common core flanked by imperfect inverted repeats (19bp in attPX and 8bp in attBX). A non-palindromic central dinucleotide (5'-GT) determines the directionality of integration." [PMID:14636570]
synonym: "change induced by Bxb1 integrase recombination" EXACT []
is_a: FBcv:0000478 ! site specific recombination
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-12T10:56:07Z" xsd:dateTime

[Term]
id: FBcv:0005001
name: experimental tool descriptor
def: "Term that describes the use of an experimental tool." [FBC:GM]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005002
name: gene product detection tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that gene product by an experimental method." [FBC:GM]
synonym: "gene product detection tag" RELATED [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005003
name: RNA detection tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the RNA product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that RNA product by an experimental method." [FBC:GM]
synonym: "RNA detection tag" RELATED [FBC:TJ]
is_a: FBcv:0005002 ! gene product detection tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005004
name: protein detection tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that protein product by an experimental method." [FBC:GM]
synonym: "protein detection tag" RELATED [FBC:TJ]
is_a: FBcv:0005002 ! gene product detection tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005005
name: reporter enzyme
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity can be used to detect the presence of that protein product." [FBC:GM]
subset: common_tool_use
xref: MI:0365
is_a: FBcv:0005004 ! protein detection tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005006
name: fluorescent protein
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that exhibits the property of fluorescence, that can be used to detect the presence of that protein product. A fluorescent protein emits light following the absorption of radiation, with the wavelength of the emitted light being longer than the excitation wavelength of the absorbed radiation." [FBC:GM]
subset: common_tool_use
xref: MI:0687
is_a: FBcv:0005004 ! protein detection tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005007
name: green fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 499-519nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005008
name: blue fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 424-467nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005009
name: cyan fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 474-492nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
xref: MI:0733
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005010
name: yellow fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 524-538nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
xref: MI:0368
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005011
name: orange fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 559-572nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005012
name: red fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 574-610nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
xref: MI:0732
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005013
name: far-red fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 625-659nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005014
name: infra-red fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak equal or greater than 670nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005015
name: modulatable fluorescent protein
namespace: experimental_tool_descriptor
def: "A fluorescent protein whose spectral properties are changeable, resulting from a reversible or irreversible change in fluorophore conformation. Changes in fluorophore conformation may occur either as a function of time (in the case of fluorescent timer proteins), or in response to an external trigger such as irradiation with a specific wavelength of light (in the case of photomodulatable fluorescent proteins)." [FBC:TEMJ]
is_a: FBcv:0005006 ! fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005016
name: photomodulatable fluorescent protein
namespace: experimental_tool_descriptor
def: "A fluorescent protein whose spectral properties can be modulated by exposure to light of a specific wavelength, triggering a conformational change of the fluorophore and subsequent change in fluorescent state." [FBC:TEMJ, PMID:20539741]
is_a: FBcv:0005015 ! modulatable fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005017
name: photoactivatable fluorescent protein
namespace: experimental_tool_descriptor
def: "A protein that can be switched from an essentially non-fluorescent state to a fluorescent state by irradiation with a pulse of light of a specific wavelength. This activation is irreversible." [FBC:GM, http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/]
is_a: FBcv:0005016 ! photomodulatable fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005018
name: photoconvertible fluorescent protein
namespace: experimental_tool_descriptor
def: "A protein that can be converted from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) by irradiation with a pulse of light of a specific wavelength. This conversion is irreversible." [FBC:GM, http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/]
is_a: FBcv:0005016 ! photomodulatable fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005019
name: photoswitchable fluorescent protein
namespace: experimental_tool_descriptor
def: "A protein that can be reversibly switched between a non-fluorescent state and a fluorescent state, or between two different fluorescent states. The switch from one state to the other is triggered by irradiation with a pulse of light of a specific wavelength, and the switch back to the original state is triggered with a pulse of light of another specific wavelength." [FBC:GM, FBC:TEMJ, http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/]
is_a: FBcv:0005016 ! photomodulatable fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005020
name: fluorescent timer protein
namespace: experimental_tool_descriptor
def: "A protein that converts from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) over time." [FBC:GM]
is_a: FBcv:0005015 ! modulatable fluorescent protein
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005021
name: epitope tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an epitope that can be used to detect the presence of the tagged protein product. An epitope (SO:0001018) is defined as 'A binding site that, in the molecule, interacts selectively and non-covalently with antibodies, B cells or T cells.'" [FBC:GM]
is_a: FBcv:0005004 ! protein detection tool
is_a: FBcv:0007029 ! specific binding tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005022
name: gene product localization tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged gene product either to a specific subcellular location within the cell or for secretion to the extracellular space." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005023
name: protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein either to a specific subcellular location within the cell or for secretion to the extracellular space." [FBC:GM, http://en.wikipedia.org/wiki/Target_peptide]
xref: SO:0001527
is_a: FBcv:0005022 ! gene product localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005024
name: nuclear protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005025
name: mitochondrial protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the mitochondrion." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005026
name: peroxisomal protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the peroxisome." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005027
name: centrosome protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the centrosome." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005028
name: microtubule protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the microtubule." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005029
name: endoplasmic reticulum protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the endoplasmic reticulum." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005030
name: Golgi protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the Golgi apparatus." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005031
name: membrane protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a cellular membrane. The membrane targeting sequence may be an intrinsic component of the membrane (GO:0031224), having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane; or may be an extrinsic component of the membrane (GO:0019898), being loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [FBC:GM, GOC:dos, GOC:jl, GOC:mah]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005032
name: plasma membrane protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the plasma membrane." [FBC:GM]
is_a: FBcv:0005031 ! membrane protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005033
name: vesicle protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a vesicle." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005034
name: signal sequence
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the secretory pathway. This results in the protein either being secreted or inserted into a cellular membrane, depending on the presence of other specific sequences in the tagged protein. The signal sequence must be fused to the N-terminal end of the tagged protein." [FBC:GM, http://en.wikipedia.org/wiki/Signal_peptide]
xref: SO:0000418
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005035
name: nuclear export signal
namespace: experimental_tool_descriptor
def: "A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm." [FBC:GM, http://en.wikipedia.org/wiki/Nuclear_export_signal, SO:0001531]
synonym: "NES" EXACT []
xref: SO:0001531
is_a: FBcv:0005023 ! protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005036
name: purification tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific, novel property that facilitates purification of the gene product and/or any associated macromolecular complex by an experimental method." [FBC:GM]
synonym: "isolation tag" EXACT []
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005037
name: gene product activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to regulate the activity of the tagged gene product." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005038
name: conditional activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0005037 ! gene product activity regulation tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005039
name: light-regulated activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to irradiation with a pulse of light." [FBC:GM]
synonym: "light-dependent activity regulation tag" EXACT []
is_a: FBcv:0005038 ! conditional activity regulation tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005040
name: small molecule-regulated activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
synonym: "small molecule-dependent activity regulation tag" EXACT []
is_a: FBcv:0005038 ! conditional activity regulation tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005041
name: chromophore-assisted light inactivation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein encoded by a transgenic locus or modified endogenous locus and which allows a protein to be inactivated by the chromophore-assisted light inactivation (CALI) technique. The tag consists of a peptide sequence that specifically binds a membrane-permeable, chromophore-containing molecule. When activated using a pulse of high-intensity light that is absorbed by the chromophore but not by cellular components, the membrane-permeable molecule generates short-lived reactive oxygen species which inactivate the tagged protein to which the molecule is bound via the chromophore-assisted light inactivation tag." [FBC:GM, PMID:14625562, PMID:16605242, PMID:21226520, PMID:3399501]
synonym: "CALI tag" EXACT []
is_a: FBcv:0005039 ! light-regulated activity regulation tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005042
name: gene product degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005043
name: cell cycle-regulated gene product degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by the cell cycle." [FBC:GM]
is_a: FBcv:0009016 ! conditional gene product degradation tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005044
name: genetically encoded sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of a biologically relevant property that is not part of or directly encoded by the genome, for example pH, redox state, membrane potential, a change in concentration of a particular molecule. For experimental tools that are used to detect a gene product directly encoded by the genome, see instead 'gene product detection tag'." [FBC:GM, PMID:20664080]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005045
name: small molecule sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of a molecule that is not part of or directly encoded by the genome." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005046
name: calcium ion sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of calcium ion concentration." [FBC:GM]
is_a: FBcv:0005045 ! small molecule sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005047
name: pH sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of pH." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005048
name: voltage sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of voltage." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005049
name: redox state sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the redox state of a cell/tissue." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005050
name: mechanical force sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of changes in the mechanical force the gene product is subjected to." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005051
name: split system component
namespace: experimental_tool_descriptor
def: "Component that forms part of a 'split system'. A split system component corresponds to a non-functional fragment of a functional experimental tool that would normally be encoded by a single gene product. When combined with another appropriate split system component in vivo, a functional experimental tool is produced. The fragments of a split system can be brought together in vivo in a number of different ways; for example, by fusing fragments to peptides that physically interact in vivo." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005052
name: split fluorescent protein
namespace: experimental_tool_descriptor
def: "Non-fluorescent fragment of a fluorescent protein. A functional fluorophore can be reconstituted if a split fluorescent protein fragment is expressed with a complementary split fluorescent protein fragment and the fragments are brought together in vivo, permitting the study of biological interactions. Protein-protein interactions can be studied using the bimolecular fluorescence complementation (BiFC) technique, where a fluorescent protein is reconstituted if the two complementary split fluorescent protein fragments are fused to interacting proteins or protein domains that bring the split halves together into the same macromolecular complex. Associations between closely apposed cells can be studied if the two complementary split fluorescent protein fragments are tethered to the surface of these cells, for example to study connectivity in the nervous system using the GFP Reconstitution Across Synaptic Partners (GRASP) technique." [FBC:GM, PMID:11983170, PMID:18255029]
is_a: FBcv:0005051 ! split system component
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005053
name: split reporter enzyme
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes a catalytically inactive fragment of an enzyme whose activity can be used to detect the presence of that protein product when complementary split reporter enzyme fragments are brought together in vivo. Fragments may be brought together when fused to peptides that physically interact, permitting the study of protein-protein interactions." [FBC:GM, http://orcid.org/0000-0002-1373-1705, PMID:9237989]
is_a: FBcv:0005051 ! split system component
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005054
name: split driver - DNA-binding fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that includes a DNA-binding domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a transcription activation domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments." [FBC:GM]
is_a: FBcv:0009027 ! split driver fragment
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005055
name: split driver - transcription activation fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that includes a transcription activation domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a DNA-binding domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments." [FBC:GM]
subset: common_tool_use
is_a: FBcv:0009027 ! split driver fragment
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005056
name: gene product cleavage tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which allows the tagged gene product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process." [FBC:GM]
is_a: FBcv:0009022 ! gene product engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005057
name: protein cleavage tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process. Examples of protein cleavage tags include sequences recognized and cleaved by proteases such as the human rhinovirus (HRV) 3C protease (often produced with the tradename PreScission Protease) and the tobacco etch virus (TEV) protease. Protein product cleavage can be used for a number of different purposes, including release of a protein after purification, or removal of a detection tag to assess that the tag does not interfere with protein function." [FBC:GM, FBC:TEMJ]
is_a: FBcv:0005056 ! gene product cleavage tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005058
name: binary expression system component
namespace: experimental_tool_descriptor
def: "Component that forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005059
name: binary expression system - driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that is encoded by a transgenic locus or modified endogenous locus and which forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
subset: common_tool_use
is_a: FBcv:0005058 ! binary expression system component
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005060
name: binary expression system - regulatory region
namespace: experimental_tool_descriptor
def: "Specific DNA sequence that is used as the effector in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
synonym: "binary expression system - effector" EXACT []
is_a: FBcv:0005058 ! binary expression system component
is_a: FBcv:0005082 ! engineered transcription regulatory region
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005061
name: binary expression system - repressor
namespace: experimental_tool_descriptor
def: "Repressor that can be used to regulate expression in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
subset: common_tool_use
is_a: FBcv:0005058 ! binary expression system component
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005062
name: recombinase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site. The recognition site for a particular site-specific recombinase is defined by the enzyme itself. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
subset: common_tool_use
synonym: "site-specific recombinase" EXACT []
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005063
name: recombinase target site
namespace: experimental_tool_descriptor
def: "The recognition site for a particular site-specific recombinase, an enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a copy of the recognition site. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
synonym: "site-specific recombination target region" EXACT []
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-06-28T11:41:27Z" xsd:dateTime

[Term]
id: FBcv:0005064
name: binary expression system - conditional driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a conditional driver permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005059 ! binary expression system - driver
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005065
name: binary expression system - small molecule-regulated driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by binding to a small molecule, such as an ion or ligand. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a small molecule-regulated driver permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005064 ! binary expression system - conditional driver
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005066
name: binary expression system - conditional repressor
namespace: experimental_tool_descriptor
def: "Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a conditional repressor permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005061 ! binary expression system - repressor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005067
name: binary expression system - temperature conditional repressor
namespace: experimental_tool_descriptor
def: "Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated by temperature. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a temperature conditional repressor permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005066 ! binary expression system - conditional repressor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005068
name: insertional mutagenesis tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which is designed to impact or assess any proximate gene(s) when integrated into the genome." [FBC:GM, FBC:LC]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005069
name: enhancer trap
namespace: experimental_tool_descriptor
def: "An enhancer trap cassette is designed to report or utilize the expression of endogenous enhancer elements upon integration of the cassette into the genome. The basic components of an enhancer trap cassette are a minimal promoter element fused upstream of a gene. Upon integration into the genome, a neighboring genomic enhancer may activate expression of the gene encoded by the enhancer trap cassette. Depending on the nature of this gene, the insertion may directly report the expression pattern of the 'trapped' enhancer (e.g. if the gene encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encodes a driver that forms part of a binary expression system). An enhancer trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. An enhancer trap insertion can be mutagenic, disrupting the function of an endogenous locus, depending on the particular insertion site." [FBC:GM, FlyBase:FBrf0128252, FlyBase:FBrf0216478, PMID:10899970]
synonym: "enhancer detection tool" RELATED [FBC:GM]
xref: SO:0001479
is_a: FBcv:0005068 ! insertional mutagenesis tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005070
name: protein trap
namespace: experimental_tool_descriptor
def: "A protein trap cassette is designed to tag protein(s) encoded by an endogenous locus upon integration of the cassette into the genome. The basic structure of a protein trap cassette is an artificial exon composed of a splice acceptor site, an open reading frame without initiation and stop codons, and a splice donor site. No promoter sequences are present. Upon integration into a coding intron of an endogenous locus, the open reading frame (ORF) encoded by the artificial exon can be incorporated into ('tag') the protein encoded by the locus. This only occurs if the insertion is in the correct orientation and when the frame of the artificial exon corresponds to that of the preceeding exon. Thus, only one out of six insertions in a coding intron will function as a protein trap. To account for each reading frame, three versions of a given protein trap element, differing only in the splice phase, are typically produced for use in an insertional mutagenesis screen. Depending on the nature of the ORF encoded by the artificial exon, the tag may be used to detect the expression pattern and/or subcellular localization of the protein (e.g. if the tag is an epitope tag or fluorescent protein), to drive expression of a gene of interest (e.g. if the tag is a driver that forms part of a binary expression system), or may modify the properties of the endogenous protein (e.g. if the tag affects protein localization or stability). A protein trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. The presence of the splice acceptor and donor sites mean that a protein trap cassette is not inherently mutagenic, since it is designed to insert in frame into a protein. However, an insertion into an intron that splits a critical functional or localization domain may alter the activity of the encoded protein, and the protein trap tag sequence itself may be designed to alter function (for example targeting the protein to a new location within the cell or altering its stability)." [FBC:GM, FlyBase:FBrf0216478, FlyBase:FBrf0236840]
is_a: FBcv:0005068 ! insertional mutagenesis tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005071
name: gene trap
namespace: experimental_tool_descriptor
def: "A gene trap cassette is designed to interrupt transcription of an endogenous locus upon integration of the cassette into the genome. The basic components of a gene trap cassette are a promoterless gene with an upstream splice acceptor site. Upon integration into an intron, splicing from the genomic splice donor site to the splice acceptor site in the cassette results in a transcriptional fusion containing the endogenous exon(s) upstream of the insertion fused to the gene sequence encoded by the cassette. Any open reading frame (ORF) encoded by the trap cassette gene may be translated from this transcriptional fusion either as a translational fusion with any ORF sequence encoded by the upstream exons, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the gene trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Gene trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript. Depending on the nature of the gene encoded by the gene trap cassette, a gene trap insertion may directly report the expression pattern of the disrupted locus (e.g. if it encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest in the pattern of the trapped locus (e.g. if it is a driver that forms part of a binary expression system). A gene trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR." [FBC:GM, http://www.genetrap.org/tutorials/overview.html#vector, PMID:10899970]
xref: SO:0001477
is_a: FBcv:0005068 ! insertional mutagenesis tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005072
name: polyA trap
namespace: experimental_tool_descriptor
def: "The basic components of a polyA trap cassette are a promoter fused to a gene sequence that lacks a polyadenylation (polyA) sequence but is followed by a splice donor sequence. If the cassette is integrated into the genome outside a gene, the mRNA produced by the polyA trap is not polyadenylated and is expected to be rapidly degraded. However, if the cassette is integrated into an intron, the promoter in the polyA trap will drive expression of a transcriptional fusion containing the polyA gene trap fused to any downstream exons. The downstream terminal exon can provide a polyA signal, allowing stable expression of the gene encoded by the polyA trap. polyA trap cassettes can be used to report the expression of genes that are not normally expressed, or are expressed at very low levels, or may be used as a marker of successful integration of an insertion into a transcription unit. A polyA trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR." [FBC:GM, FlyBase:FBrf0132344, FlyBase:FBrf0206814, http://www.genetrap.org/tutorials/overview.html#vector, PMID:9560157]
is_a: FBcv:0005068 ! insertional mutagenesis tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005073
name: promoter trap
namespace: experimental_tool_descriptor
def: "The basic component of a promoter trap cassette is a promoterless gene. This gene is not flanked by splice acceptor or donor sites, and thus the gene within a promoter trap can only be expressed if the cassette integrates into the genome within an exon, resulting in a transcriptional fusion. If the promoter trap gene encodes an open reading frame (ORF) and the insertion is in the correct frame, the trap ORF may be translated from this transcriptional fusion either as a translational fusion with ORF sequence of the disrupted endogenous locus, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the promoter trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Depending on the nature of the gene encoded by the promoter trap cassette, the insertion may directly report the expression pattern of the 'trapped' locus (e.g. if the gene encoded by the cassette is a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encoded by the cassette is a driver that form part of a binary expression system). A promoter trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. Promoter trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript." [FBC:GM, PMID:10899970]
is_a: FBcv:0005068 ! insertional mutagenesis tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005074
name: misexpression element
namespace: experimental_tool_descriptor
def: "The basic components of a misexpression element are an enhancer sequence plus a minimal promoter. Upon integration into the genome, this element can activate expression of nearby endogenous loci. Typically, constructs containing misexpression elements are designed to insert at or near the 5' end of a gene, such that expression from the promoter within the misexpression element drives overexpression of the endogenous locus and causes a gain-of-function phenotype. However, if the insertion is within a locus, a truncated product may be produced, while an insertion in the opposite orientation to that of the direction of transcription of the endogenous locus can result in the production of an antisense transcript. If the enhancer present in the misexpression element forms part of a binary expression system, the misexpression pattern of the endogenous gene is controlled by combining the misexpression element insertion with a driver expressed in the desired temporal and spatial pattern." [FBC:GM, FlyBase:FBrf0090768]
is_a: FBcv:0005068 ! insertional mutagenesis tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005075
name: genome engineering tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to an modify an organism's genetic material in a defined manner. Genome engineering can occur on many levels, ranging from targeting of an individual gene with a small modification through to the engineering of chromosomal rearrangements. In addition to the manipulation of endogenous loci, genome engineering can also be used to introduce exogenous material into the genome, and to manipulate such exogenous material already introduced the genome." [FlyBase:FBrf0231034]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005076
name: integrase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
subset: common_tool_use
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005077
name: nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome." [FBC:GM, FlyBase:FBrf0231034]
subset: common_tool_use
synonym: "site-specific DNA nuclease" RELATED [FBC:GM]
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005078
name: RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest, rather than being an inherent property of the nuclease itself." [FBC:GM, FlyBase:FBrf0231034]
subset: common_tool_use
is_a: FBcv:0005077 ! nuclease
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005079
name: integrase target site
namespace: experimental_tool_descriptor
def: "A recognition site for an integrase, an enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005080
name: nuclease target site
namespace: experimental_tool_descriptor
def: "A recognition site for a site-specific DNA nuclease, an enzyme that catalyzes hydrolysis of DNA in a site-specific manner. The DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome." [FBC:GM, FlyBase:FBrf0231034]
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005081
name: engineered regulatory region
namespace: experimental_tool_descriptor
def: "Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'regulatory_region' (SO:0005836). 'regulatory_region' is defined as 'A region of sequence that is involved in the control of a biological process." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005082
name: engineered transcription regulatory region
namespace: experimental_tool_descriptor
def: "Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'transcription_regulatory_region' (SO:0001679). 'transcription_regulatory_region' is defined as 'A regulatory region that is involved in the control of the process of transcription.'." [FBC:GM]
is_a: FBcv:0005081 ! engineered regulatory region
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-13T13:17:30Z" xsd:dateTime

[Term]
id: FBcv:0005083
name: small molecule-regulated gene product degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by a small molecule." [FBC:GM]
synonym: "small molecule-dependent gene product degradation tag" EXACT []
is_a: FBcv:0009016 ! conditional gene product degradation tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-0027-0858
property_value: http://purl.org/dc/terms/date "2017-12-22T13:09:10Z" xsd:dateTime

[Term]
id: FBcv:0006000
name: abnormal copulation
namespace: phenotypic_class
def: "Phenotype that is any abnormality in copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'" [FBC:TEMJ, ISBN:0721662544]
synonym: "copulation defective" EXACT []
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0006001
name: increased fecundity
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of gametes produced." [FBC:TEMJ]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006002
name: decreased fecundity
namespace: phenotypic_class
def: "Phenotype that is a decrease in the number of gametes produced." [FBC:TEMJ]
synonym: "reduced fecundity" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006003
name: population of Drosophila

[Term]
id: FBcv:0006004
name: abnormal oviposition
namespace: phenotypic_class
def: "Phenotype that is any abnormality in oviposition (GO:0018991) despite production of eggs. 'oviposition' is defined as: 'A reproductive behavior that results in the deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.'." [FBC:TEMJ, GOC:ems, PMID:18050396, PMID:31164023]
comment: This term should only be used to report defects specifically in oviposition, as opposed to an overall loss of fertility. It is not possible to observe an oviposition abnormality if eggs are not being produced. If a difference in "oviposition rate" is measured by authors as a proxy for sterility/fertility, it would be better to use the terms "sterile", "semi-sterile", or "semi-fertile", as appropriate.
synonym: "oviposition defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0006005
name: increased occurrence of cell division
namespace: phenotypic_class
def: "A phenotype that is an increased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'." [FBC:TEMJ, GOC:di, GOC:go_curators, GOC:pr]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006006
name: decreased occurrence of cell division
namespace: phenotypic_class
def: "A phenotype that is a decreased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'." [FBC:TEMJ, GOC:di, GOC:go_curators, GOC:pr]
subset: fbcvsubset_mgiribbons
synonym: "reduced occurrence of cell division" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006007
name: population of cells

[Term]
id: FBcv:0007000
name: obsolete micropublication
namespace: pub_type
def: "A short report describing a single stand-alone research finding that is peer-reviewed and published." [FBC:SM, http://www.micropublication.org]
comment: Obsoleted, as 'paper' publication type will now be used for micropublications.
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T08:45:04Z" xsd:dateTime
is_obsolete: true
replaced_by: FBcv:0000212

[Term]
id: FBcv:0007001
name: preprint
namespace: pub_type
def: "A version of a scientific manuscript that is shared publicly on the web without peer review. In most cases, work posted as a preprint will be submitted for peer review at a journal." [FBC:SM, http://www.asapbio.org/preprint-info]
is_a: FBcv:0000189 ! publication class
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T09:00:50Z" xsd:dateTime

[Term]
id: FBcv:0007002
name: neuron activity regulation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to regulate the activity of a neuron. This is often achieved by manipulation of membrane potential or synaptic transmission dynamics." [FBC:GM]
subset: common_tool_use
synonym: "electrically signalling cell activity regulation tool" EXACT []
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T09:54:56Z" xsd:dateTime

[Term]
id: FBcv:0007003
name: neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron. This is often achieved by inducing membrane hyperpolarization (GO:0060081)." [FBC:GM]
synonym: "electrically signalling cell inhibition tool" EXACT []
is_a: FBcv:0007002 ! neuron activity regulation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:13:24Z" xsd:dateTime

[Term]
id: FBcv:0007004
name: conditional neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007003 ! neuron inhibition tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:15:49Z" xsd:dateTime

[Term]
id: FBcv:0007005
name: light-regulated neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
synonym: "optogenetic neuron inhibition tool" EXACT []
is_a: FBcv:0007004 ! conditional neuron inhibition tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:17:16Z" xsd:dateTime

[Term]
id: FBcv:0007006
name: small molecule-regulated neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007004 ! conditional neuron inhibition tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:18:34Z" xsd:dateTime

[Term]
id: FBcv:0007007
name: temperature-regulated neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by temperature." [FBC:GM]
synonym: "thermogenetic neuron inhibition tool" EXACT []
is_a: FBcv:0007004 ! conditional neuron inhibition tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:20:00Z" xsd:dateTime

[Term]
id: FBcv:0007008
name: neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron. This is often achieved by inducing membrane depolarization (GO:0051899)." [FBC:GM]
synonym: "electrically signalling cell activation tool" EXACT []
is_a: FBcv:0007002 ! neuron activity regulation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:25:57Z" xsd:dateTime

[Term]
id: FBcv:0007009
name: conditional neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007008 ! neuron activation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:26:57Z" xsd:dateTime

[Term]
id: FBcv:0007010
name: temperature-regulated neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by temperature." [FBC:GM]
synonym: "thermogenetic neuron activation tool" EXACT []
is_a: FBcv:0007009 ! conditional neuron activation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:28:57Z" xsd:dateTime

[Term]
id: FBcv:0007011
name: light-regulated neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
synonym: "optogenetic neuron activation tool" EXACT []
is_a: FBcv:0007009 ! conditional neuron activation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:31:02Z" xsd:dateTime

[Term]
id: FBcv:0007012
name: small molecule-regulated neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007009 ! conditional neuron activation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:34:48Z" xsd:dateTime

[Term]
id: FBcv:0007013
name: cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure." [FBC:GM]
subset: common_tool_use
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:53:21Z" xsd:dateTime

[Term]
id: FBcv:0007014
name: conditional cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007013 ! cell ablation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:54:32Z" xsd:dateTime

[Term]
id: FBcv:0007015
name: temperature-regulated cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by temperature." [FBC:GM]
is_a: FBcv:0007014 ! conditional cell ablation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:55:40Z" xsd:dateTime

[Term]
id: FBcv:0007016
name: light-regulated cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0007014 ! conditional cell ablation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:56:47Z" xsd:dateTime

[Term]
id: FBcv:0007017
name: small molecule-regulated cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007014 ! conditional cell ablation tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T10:57:45Z" xsd:dateTime

[Term]
id: FBcv:0007018
name: biological process activity sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific biological process." [FBC:GM]
synonym: "reporter of biological process pathway activity" EXACT []
is_a: FBcv:0005044 ! genetically encoded sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T11:38:48Z" xsd:dateTime

[Term]
id: FBcv:0007019
name: signal transduction pathway activity sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific signal transduction pathway." [FBC:GM]
synonym: "reporter of signal transduction pathway activity" EXACT []
is_a: FBcv:0007018 ! biological process activity sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T11:41:19Z" xsd:dateTime

[Term]
id: FBcv:0007020
name: gene product activity sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activation state of a specific gene product." [FBC:GM]
synonym: "gene product activation state detection tool" EXACT []
is_a: FBcv:0005044 ! genetically encoded sensor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T11:43:24Z" xsd:dateTime

[Term]
id: FBcv:0007021
name: proximity labeling tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring macromolecules, facilitating the subsequent purification or detection of the tagged macromolecules by an experimental method." [FBC:GM, PMID:30774936]
subset: common_tool_use
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T14:01:14Z" xsd:dateTime

[Term]
id: FBcv:0007022
name: proximity labeling tool (protein)
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring proteins, facilitating the subsequent purification or detection of the tagged proteins by an experimental method." [FBC:GM, PMID:29125959, PMID:30774936]
is_a: FBcv:0007021 ! proximity labeling tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T14:08:26Z" xsd:dateTime

[Term]
id: FBcv:0007023
name: proximity labeling tool (RNA)
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring RNA, facilitating the subsequent purification or detection of the tagged RNA by an experimental method." [FBC:GM, PMID:30774936]
is_a: FBcv:0007021 ! proximity labeling tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T14:18:36Z" xsd:dateTime

[Term]
id: FBcv:0007024
name: proximity labeling tool (DNA)
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring DNA, facilitating the subsequent purification or detection of the tagged DNA by an experimental method." [FBC:GM, PMID:30774936]
is_a: FBcv:0007021 ! proximity labeling tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T14:24:50Z" xsd:dateTime

[Term]
id: FBcv:0007025
name: cell labeling tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to facilitate the detection of a specific cell population by an experimental method." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T14:41:38Z" xsd:dateTime

[Term]
id: FBcv:0007026
name: multicolor cell labeling tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that can be used to stochastically label cells in the same sample with different colors of fluorescent protein. This property can be exploited to study cell morphology and to track lineages of clonally related cells." [FBC:GM, PMID:25491327]
is_a: FBcv:0007025 ! cell labeling tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T14:42:41Z" xsd:dateTime

[Term]
id: FBcv:0007027
name: small molecule-regulated protein cleavage tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process that can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0005057 ! protein cleavage tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-25T14:58:18Z" xsd:dateTime

[Term]
id: FBcv:0007028
name: split recombinase
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a recombinase. A functional recombinase can be reconstituted when complementary split recombinase fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0005051 ! split system component
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-26T07:55:34Z" xsd:dateTime

[Term]
id: FBcv:0007029
name: specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule." [FBC:GM]
subset: common_tool_use
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-26T08:11:17Z" xsd:dateTime

[Term]
id: FBcv:0007030
name: conditional specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007029 ! specific binding tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-26T08:12:05Z" xsd:dateTime

[Term]
id: FBcv:0007031
name: light-regulated specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0007030 ! conditional specific binding tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-26T08:13:06Z" xsd:dateTime

[Term]
id: FBcv:0007032
name: temperature-regulated specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by temperature." [FBC:GM]
is_a: FBcv:0007030 ! conditional specific binding tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-26T08:13:56Z" xsd:dateTime

[Term]
id: FBcv:0007033
name: small molecule-regulated specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007030 ! conditional specific binding tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-26T08:14:35Z" xsd:dateTime

[Term]
id: FBcv:0007035
name: meganuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, having a cognate recognition site of 20-30bp. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome." [FBC:GM, FlyBase:FBrf0231034]
is_a: FBcv:0005077 ! nuclease
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2019-06-26T09:17:20Z" xsd:dateTime

[Term]
id: FBcv:0007036
name: lecture
namespace: pub_type
def: "Work consisting of speeches read or delivered before an audience or class, especially for instruction or to set forth some subject." [MeSH:D019531]
is_a: FBcv:0000189 ! publication class
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-01-23T15:24:54Z" xsd:dateTime

[Term]
id: FBcv:0007037
name: antibody
namespace: experimental_tool_descriptor
def: "An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact with the antigen that induced its synthesis and with molecules containing structures similar to that antigen. An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses." [XCO:0000194]
subset: common_tool_use
xref: XCO:0000194
is_a: FBcv:0007029 ! specific binding tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-01-24T08:44:55Z" xsd:dateTime

[Term]
id: FBcv:0007038
name: light conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence or absence of light, which may be white light or particular wavelength(s)." [FBC:CP]
is_a: FBcv:0000309 ! conditional
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-01-24T09:10:41Z" xsd:dateTime

[Term]
id: FBcv:0007039
name: engineered antibody
namespace: experimental_tool_descriptor
def: "An antibody whose domain architecture has been engineered in vitro. An engineered antibody typically contains only a subset of the domains found in a naturally occurring antibody. In some cases, domains that are normally found in different chains of a naturally occurring antibody are synthesized as a single fusion protein." [FBC:GM]
is_a: FBcv:0007037 ! antibody
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-03T11:36:12Z" xsd:dateTime

[Term]
id: FBcv:0007040
name: nanobody
namespace: experimental_tool_descriptor
def: "An engineered antibody consisting of the antigen-binding variable domain (VHH domain) of a camelid single-domain heavy chain antibody (HCab)." [FBC:GM, PMID:22886243, PMID:8502296, PMID:9323027]
is_a: FBcv:0007039 ! engineered antibody
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-03T11:51:11Z" xsd:dateTime

[Term]
id: FBcv:0007041
name: single-chain variable fragment antibody
namespace: experimental_tool_descriptor
def: "An engineered antibody consisting of the heavy (VH) and light (VL) chains of an immunoglobulin, separated by a short flexible linker peptide and expressed as a single fusion protein." [FBC:GM, PMID:3045807]
synonym: "scFv antibody" EXACT [FBC:GM]
synonym: "sFv antibody" EXACT [PMID:3045807]
synonym: "single-chain variable region fragment antibody" EXACT [PMID:3045807]
is_a: FBcv:0007039 ! engineered antibody
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-03T12:25:24Z" xsd:dateTime

[Term]
id: FBcv:0007042
name: RMCE target element
namespace: experimental_tool_descriptor
def: "An RMCE target element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this target sequence cassette can be replaced with donor sequence from a compatible RMCE donor element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction." [FBC:GM, FlyBase:FBrf0231034, PMID:21445009, PMID:7947678]
synonym: "recombination-mediated cassette exchange target element" EXACT []
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-03T14:52:50Z" xsd:dateTime

[Term]
id: FBcv:0007043
name: RMCE donor element
namespace: experimental_tool_descriptor
def: "An RMCE donor element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this donor sequence cassette can be used to replace target sequence of a compatible RMCE target element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction." [FBC:GM, FlyBase:FBrf0231034, PMID:21445009, PMID:7947678]
synonym: "recombination-mediated cassette exchange donor element" EXACT []
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-03T15:00:41Z" xsd:dateTime

[Term]
id: FBcv:0007044
name: docking element
namespace: experimental_tool_descriptor
def: "A docking element is an element that has been introduced into a site in the genome to allow integration of DNA at a defined location; this neutralizes the problem of position effects that are seen with non-specific insertion techniques such as transposable-element-mediated transgenesis. A docking element contains a single target site for an integrase, allowing subsequent integration of DNA into this site from a donor element via integrase mediated recombination. The docking element in the genome typically contains the 'attB' site and the donor plasmid contains the 'attP' site, since this directionality gives higher integration rates compared to the alternative combination where the 'attB' site is integrated into the genome. A docking element insertion is typically selected to be 'benign' (that is it does not result in disruption of an endogenous locus) and to show a high rate of integration in the presence of integrase." [FBC:GM, FlyBase:FBrf0192974, FlyBase:FBrf0194996, FlyBase:FBrf0231034, PMID:11359900, PMID:12563279]
comment: This includes any element containing a single site for integrase-mediated integration, as in FBrf0231034 Fig 10a, but not elements with multiple integrase sites, as in FBrf0231034 Fig 10b (see FBcv:0007042 - RMCE target element). Elements with sites for recombinase-mediated exchange (as in FBrf0231034 Fig 10c) are only included if they additionally carry exactly one integrase site for integrase-mediated integration.
synonym: "docking site element" EXACT []
synonym: "landing site element" EXACT []
is_a: FBcv:0005075 ! genome engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-03T15:54:09Z" xsd:dateTime

[Term]
id: FBcv:0007045
name: RNA engineering tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify an RNA of interest in a defined manner. Examples of RNA engineering include the targeting of an individual transcript for knockdown, and targeted manipulation of RNA splicing or editing." [FBC:GM, PMID:30021724, PMID:30388409, PMID:31367845]
subset: common_tool_use
is_a: FBcv:0009022 ! gene product engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-04T09:01:14Z" xsd:dateTime

[Term]
id: FBcv:0007046
name: RNA-guided ribonuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of RNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the target RNA sequence of interest, rather than being an inherent property of the ribonuclease itself. This property can be used to modify an organism's transcriptome in a defined manner." [FBC:GM, PMID:30021724, PMID:30388409, PMID:31367845]
subset: common_tool_use
is_a: FBcv:0007045 ! RNA engineering tool
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-02-04T09:12:14Z" xsd:dateTime

[Term]
id: FBcv:0007047
name: light-regulated gene product degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0009016 ! conditional gene product degradation tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-10T13:05:28Z" xsd:dateTime

[Term]
id: FBcv:0007048
name: decreased number
namespace: structural_qualifier
def: "Present in the correct location but in smaller numbers than in wild-type." [FBC:CP]
is_a: FBcv:0000014 ! structural qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-14T14:38:52Z" xsd:dateTime

[Term]
id: FBcv:0007049
name: absent
namespace: structural_qualifier
def: "Anatomical structure that would be present in wild-type is not present." [FBC:CP]
xref: PATO:0000462
is_a: FBcv:0000014 ! structural qualifier
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-14T14:39:35Z" xsd:dateTime

[Term]
id: FBcv:0007050
name: somatic clone - tissue specific
namespace: clone_qualifier
def: "A clone of somatic cells that share a genotype that is different from the genotype of the animal and are intentionally generated in a specific tissue of the organism." [FBC:AO]
is_a: FBcv:0000336 ! somatic clone
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-26T09:58:12Z" xsd:dateTime

[Term]
id: FBcv:0007051
name: somatic clone - tissue specific, Minute background
namespace: clone_qualifier
def: "A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that are part of and derived from an animal with a different genotype that includes being Minute +/- and are intentionally generated in a specific tissue of the organism." [FBC:CP]
is_a: FBcv:0000722 ! somatic clone - Minute background
is_a: FBcv:0007050 ! somatic clone - tissue specific
intersection_of: FBcv:0000722 ! somatic clone - Minute background
intersection_of: FBcv:0007050 ! somatic clone - tissue specific
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-26T10:04:31Z" xsd:dateTime

[Term]
id: FBcv:0007052
name: light-regulated nuclear export signal
namespace: experimental_tool_descriptor
def: "A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm, where this property can be regulated by irradiation with a pulse of light." [FBC:GM, FlyBase:FBrf0253050, PMID:26853913]
is_a: FBcv:0005035 ! nuclear export signal
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-04-26T11:49:16Z" xsd:dateTime

[Term]
id: FBcv:0007053
name: obsolete conditional split driver - transcription activation fragment
def: "Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:32:02Z" xsd:dateTime
is_obsolete: true
consider: FBcv:0005055
consider: FBcv:0009028

[Term]
id: FBcv:0007054
name: obsolete light-regulated split driver - transcription activation fragment
def: "Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:33:41Z" xsd:dateTime
is_obsolete: true
consider: FBcv:0005055
consider: FBcv:0009029

[Term]
id: FBcv:0007055
name: obsolete small molecule-regulated split driver - transcription activation fragment
def: "Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:34:38Z" xsd:dateTime
is_obsolete: true
consider: FBcv:0005055
consider: FBcv:0009030

[Term]
id: FBcv:0007056
name: obsolete conditional split driver - DNA-binding fragment
def: "Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:35:30Z" xsd:dateTime
is_obsolete: true
consider: FBcv:0005054
consider: FBcv:0009028

[Term]
id: FBcv:0007057
name: obsolete light-regulated split driver - DNA-binding fragment
def: "Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:37:56Z" xsd:dateTime
is_obsolete: true
consider: FBcv:0005054
consider: FBcv:0009029

[Term]
id: FBcv:0007058
name: obsolete small molecule-regulated split driver - DNA-binding fragment
def: "Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:38:38Z" xsd:dateTime
is_obsolete: true
consider: FBcv:0005054
consider: FBcv:0009030

[Term]
id: FBcv:0007059
name: conditional recombinase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0005062 ! recombinase
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:52:00Z" xsd:dateTime

[Term]
id: FBcv:0007060
name: small molecule-regulated recombinase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007059 ! conditional recombinase
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:53:20Z" xsd:dateTime

[Term]
id: FBcv:0007061
name: conditional split recombinase
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007028 ! split recombinase
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:56:23Z" xsd:dateTime

[Term]
id: FBcv:0007062
name: light-regulated split recombinase
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0007061 ! conditional split recombinase
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-05-04T14:57:37Z" xsd:dateTime

[Term]
id: FBcv:0007063
name: light-regulated nuclear protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0005024 ! nuclear protein localization tag
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-19T13:19:05Z" xsd:dateTime

[Term]
id: FBcv:0007064
name: binary expression system - light-regulated driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by irradiation with a pulse of light. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a light-regulated driver permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005064 ! binary expression system - conditional driver
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2023-01-18T11:52:12Z" xsd:dateTime

[Term]
id: FBcv:0007500
name: abnormal anesthesia-resistant memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in anesthesia-resistant memory (GO:0007615). 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.'" [PMID:15143285, PMID:17088531]
is_a: FBcv:0000398 ! abnormal memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T14:46:41Z" xsd:dateTime

[Term]
id: FBcv:0007501
name: abnormal short-term memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in short-term memory (GO:0007614). 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.'" [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
is_a: FBcv:0000398 ! abnormal memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T14:50:19Z" xsd:dateTime

[Term]
id: FBcv:0007502
name: abnormal medium-term memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in medium-term memory (GO:0072375). 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).'" [GOC:sart, PMID:14659098, PMID:7923375]
is_a: FBcv:0000398 ! abnormal memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T14:51:08Z" xsd:dateTime

[Term]
id: FBcv:0007503
name: abnormal long-term memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in long-term memory (GO:0007616). 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.'" [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
is_a: FBcv:0000398 ! abnormal memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T14:51:45Z" xsd:dateTime

[Term]
id: FBcv:0007504
name: abnormal body weight
namespace: phenotypic_class
def: "Phenotype that is any abnormality in body weight compared to identically raised wild-type controls." [FBC:CP]
is_a: FBcv:0001347 ! phenotype
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T15:47:07Z" xsd:dateTime

[Term]
id: FBcv:0007505
name: increased body weight
namespace: phenotypic_class
def: "Phenotype that is an increase in body weight compared to identically raised wild-type controls." [FBC:CP]
is_a: FBcv:0007504 ! abnormal body weight
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T15:50:18Z" xsd:dateTime

[Term]
id: FBcv:0007506
name: decreased body weight
namespace: phenotypic_class
def: "Phenotype that is a decrease in body weight compared to identically raised wild-type controls." [FBC:CP]
synonym: "reduced body weight" EXACT []
is_a: FBcv:0007504 ! abnormal body weight
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T15:50:44Z" xsd:dateTime

[Term]
id: FBcv:0007507
name: increased size
namespace: phenotypic_class
def: "A phenotype that is an increase in the size of the whole body or some body part compared to wild-type." [FBC:CP]
is_a: FBcv:0000357 ! abnormal size
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T15:52:00Z" xsd:dateTime

[Term]
id: FBcv:0007508
name: decreased size
namespace: phenotypic_class
def: "A phenotype that is a decrease in the size of the whole body or some body part compared to wild-type." [FBC:CP]
synonym: "reduced size" EXACT []
is_a: FBcv:0000357 ! abnormal size
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-15T15:52:59Z" xsd:dateTime

[Term]
id: FBcv:0007509
name: increased rate of phototaxis
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.'" [FBC:CP, GOC:jl, ISBN:0192800981]
is_a: FBcv:0000413 ! abnormal phototaxis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T09:10:39Z" xsd:dateTime

[Term]
id: FBcv:0007510
name: decreased rate of phototaxis
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.'" [FBC:CP, GOC:jl, ISBN:0192800981]
synonym: "reduced rate of phototaxis" EXACT []
is_a: FBcv:0000413 ! abnormal phototaxis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T09:20:20Z" xsd:dateTime

[Term]
id: FBcv:0007511
name: increased rate of cell adhesion
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.'" [FBC:CP, GOC:hb, GOC:pf]
is_a: FBcv:0000668 ! abnormal cell adhesion
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T09:21:22Z" xsd:dateTime

[Term]
id: FBcv:0007512
name: decreased rate of cell adhesion
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.'" [FBC:CP, GOC:hb, GOC:pf]
synonym: "reduced rate of cell adhesion" EXACT []
is_a: FBcv:0000668 ! abnormal cell adhesion
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T09:22:22Z" xsd:dateTime

[Term]
id: FBcv:0007513
name: increased sleep
namespace: phenotypic_class
def: "Phenotype that is an increase in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.'" [FBC:CP, ISBN:0192800981]
is_a: FBcv:0000705 ! abnormal sleep
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T12:02:45Z" xsd:dateTime

[Term]
id: FBcv:0007514
name: decreased sleep
namespace: phenotypic_class
def: "Phenotype that is a decrease in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.'" [FBC:CP, ISBN:0192800981]
synonym: "reduced sleep" EXACT []
is_a: FBcv:0000705 ! abnormal sleep
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T12:12:40Z" xsd:dateTime

[Term]
id: FBcv:0007515
name: increased rate of feeding behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.'" [FBC:DOS, GOC:mah]
is_a: FBcv:0000419 ! abnormal feeding behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T12:14:26Z" xsd:dateTime

[Term]
id: FBcv:0007516
name: decreased rate of feeding behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.'" [FBC:DOS, GOC:mah]
synonym: "reduced rate of feeding behavior" EXACT []
is_a: FBcv:0000419 ! abnormal feeding behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2020-12-16T12:16:19Z" xsd:dateTime

[Term]
id: FBcv:0007517
name: increased efficacy of memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).'" [FBC:CP, GOC:curators, ISBN:0582227089]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with memory formation.
synonym: "improved memory" EXACT []
is_a: FBcv:0000398 ! abnormal memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T11:45:09Z" xsd:dateTime

[Term]
id: FBcv:0007518
name: decreased efficacy of memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).'" [FBC:CP, GOC:curators, ISBN:0582227089]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with memory formation.
synonym: "impaired memory" EXACT []
synonym: "reduced efficacy of memory" EXACT []
is_a: FBcv:0000398 ! abnormal memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T11:55:18Z" xsd:dateTime

[Term]
id: FBcv:0007519
name: increased efficacy of short-term memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with short-term memory formation.
is_a: FBcv:0007501 ! abnormal short-term memory
is_a: FBcv:0007517 ! increased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T11:56:41Z" xsd:dateTime

[Term]
id: FBcv:0007520
name: decreased efficacy of short-term memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with short-term memory formation.
synonym: "reduced efficacy of short-term memory" EXACT []
is_a: FBcv:0007501 ! abnormal short-term memory
is_a: FBcv:0007518 ! decreased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T11:57:17Z" xsd:dateTime

[Term]
id: FBcv:0007521
name: increased efficacy of long-term memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with long-term memory formation.
is_a: FBcv:0007503 ! abnormal long-term memory
is_a: FBcv:0007517 ! increased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T12:02:59Z" xsd:dateTime

[Term]
id: FBcv:0007522
name: decreased efficacy of long-term memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with long-term memory formation.
synonym: "reduced efficacy of long-term memory" EXACT []
is_a: FBcv:0007503 ! abnormal long-term memory
is_a: FBcv:0007518 ! decreased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T12:04:30Z" xsd:dateTime

[Term]
id: FBcv:0007523
name: increased efficacy of anesthesia-resistant memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.'" [FBC:CP, PMID:15143285, PMID:17088531]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with anesthesia-resistant memory formation.
is_a: FBcv:0007500 ! abnormal anesthesia-resistant memory
is_a: FBcv:0007517 ! increased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T12:08:22Z" xsd:dateTime

[Term]
id: FBcv:0007524
name: decreased efficacy of anesthesia-resistant memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.'" [FBC:CP, PMID:15143285, PMID:17088531]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with anesthesia-resistant memory formation.
synonym: "reduced efficacy of anesthesia-resistant memory" EXACT []
is_a: FBcv:0007500 ! abnormal anesthesia-resistant memory
is_a: FBcv:0007518 ! decreased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T12:10:03Z" xsd:dateTime

[Term]
id: FBcv:0007525
name: increased efficacy of medium-term memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).'" [FBC:CP, GOC:sart, PMID:14659098, PMID:7923375]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with medium-term memory formation.
is_a: FBcv:0007502 ! abnormal medium-term memory
is_a: FBcv:0007517 ! increased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T12:11:31Z" xsd:dateTime

[Term]
id: FBcv:0007526
name: decreased efficacy of medium-term memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).'" [FBC:CP, GOC:sart, PMID:14659098, PMID:7923375]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with medium-term memory formation.
synonym: "reduced efficacy of medium-term memory" EXACT []
is_a: FBcv:0007502 ! abnormal medium-term memory
is_a: FBcv:0007518 ! decreased efficacy of memory
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2021-08-06T12:12:48Z" xsd:dateTime

[Term]
id: FBcv:0007527
name: abnormal adult walking behavior
namespace: phenotypic_class
def: "Any abnormality in adult walking behavior (GO:0007628), which is defined as 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'." [GO:0007628, GOC:jid, GOC:pr, ISBN:0198606907]
is_a: FBcv:0007529 ! abnormal adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T08:45:06Z" xsd:dateTime

[Term]
id: FBcv:0007528
name: abnormal larval locomotory behavior
namespace: phenotypic_class
def: "Any abnormality in larval locomotory behavior (GO:0008345), which is defined as 'Locomotory behavior in a larval (immature) organism.'." [GO:0008345, GOC:ai]
is_a: FBcv:0000414 ! abnormal locomotor behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T08:46:33Z" xsd:dateTime

[Term]
id: FBcv:0007529
name: abnormal adult locomotory behavior
namespace: phenotypic_class
def: "Any abnormality in adult locomotory behavior (GO:0008344), which is defined as 'Locomotory behavior in a fully developed and mature organism.'." [GO:0008344, GOC:ai]
is_a: FBcv:0000414 ! abnormal locomotor behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T08:50:44Z" xsd:dateTime

[Term]
id: FBcv:0007530
name: increased efficacy of learning
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.'" [ISBN:0582227089, ISBN:0721662544]
synonym: "improved learning" EXACT []
is_a: FBcv:0000397 ! abnormal learning
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T08:57:36Z" xsd:dateTime

[Term]
id: FBcv:0007531
name: decreased efficacy of learning
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.'" [ISBN:0582227089, ISBN:0721662544]
synonym: "impaired learning" EXACT []
synonym: "reduced efficacy of learning" EXACT []
is_a: FBcv:0000397 ! abnormal learning
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T09:06:29Z" xsd:dateTime

[Term]
id: FBcv:0007532
name: increased rate of chemosensory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'." [GO:0007635, GOC:go_curators]
synonym: "increased rate of chemosensitive behavior" EXACT []
is_a: FBcv:0000403 ! abnormal chemosensory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:04:22Z" xsd:dateTime

[Term]
id: FBcv:0007533
name: increased rate of proboscis extension reflex
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'." [FB:FBrf0044924, GO:0007637, GOC:jid]
is_a: FBcv:0000680 ! abnormal proboscis extension reflex
is_a: FBcv:0007532 ! increased rate of chemosensory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:14:45Z" xsd:dateTime

[Term]
id: FBcv:0007534
name: increased rate of grooming behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'." [GO:0007625, GOC:jl, GOC:pr]
is_a: FBcv:0000420 ! abnormal grooming behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:16:08Z" xsd:dateTime

[Term]
id: FBcv:0007535
name: increased rate of locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'." [GO:0007626, GOC:dph]
is_a: FBcv:0000414 ! abnormal locomotor behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:19:14Z" xsd:dateTime

[Term]
id: FBcv:0007536
name: increased rate of adult walking behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'." [GO:0007628, GOC:jid, GOC:pr, ISBN:0198606907]
is_a: FBcv:0007527 ! abnormal adult walking behavior
is_a: FBcv:0007538 ! increased rate of adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:20:31Z" xsd:dateTime

[Term]
id: FBcv:0007537
name: increased rate of larval locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'." [GO:0008345, GOC:ai]
is_a: FBcv:0007528 ! abnormal larval locomotory behavior
is_a: FBcv:0007535 ! increased rate of locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:21:27Z" xsd:dateTime

[Term]
id: FBcv:0007538
name: increased rate of adult locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'." [GO:0008344, GOC:ai]
is_a: FBcv:0007529 ! abnormal adult locomotory behavior
is_a: FBcv:0007535 ! increased rate of locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:22:30Z" xsd:dateTime

[Term]
id: FBcv:0007539
name: increased rate of mating behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'." [GO:0007617, GOC:ai, GOC:dph]
is_a: FBcv:0000721 ! abnormal mating behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:23:15Z" xsd:dateTime

[Term]
id: FBcv:0007540
name: increased rate of courtship behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'." [GO:0007619, GOC:ai, GOC:dph]
is_a: FBcv:0000399 ! abnormal courtship behavior
is_a: FBcv:0007539 ! increased rate of mating behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:23:56Z" xsd:dateTime

[Term]
id: FBcv:0007541
name: increased rate of flight behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'." [GO:0007629, GOC:jid, ISBN:0198606907]
is_a: FBcv:0007538 ! increased rate of adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:25:01Z" xsd:dateTime

[Term]
id: FBcv:0007542
name: increased rate of jump response
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'." [GO:0007630, GOC:jid, ISBN:0198606907]
is_a: FBcv:0000720 ! abnormal jump response
is_a: FBcv:0007538 ! increased rate of adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:25:43Z" xsd:dateTime

[Term]
id: FBcv:0007543
name: increased rate of copulation
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'." [GO:0007620, ISBN:0721662544]
is_a: FBcv:0006000 ! abnormal copulation
is_a: FBcv:0007539 ! increased rate of mating behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:26:28Z" xsd:dateTime

[Term]
id: FBcv:0007544
name: decreased rate of chemosensory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'." [GO:0007635, GOC:go_curators]
synonym: "decreased rate of chemosensitive behavior" EXACT []
synonym: "reduced rate of chemosensory behavior" EXACT []
is_a: FBcv:0000403 ! abnormal chemosensory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:30:08Z" xsd:dateTime

[Term]
id: FBcv:0007545
name: decreased rate of proboscis extension reflex
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'." [FB:FBrf0044924, GO:0007637, GOC:jid]
synonym: "reduced rate of proboscis extension reflex" EXACT []
is_a: FBcv:0000680 ! abnormal proboscis extension reflex
is_a: FBcv:0007544 ! decreased rate of chemosensory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:30:42Z" xsd:dateTime

[Term]
id: FBcv:0007546
name: decreased rate of grooming behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'." [GO:0007625, GOC:jl, GOC:pr]
synonym: "reduced rate of grooming behavior" EXACT []
is_a: FBcv:0000420 ! abnormal grooming behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:31:07Z" xsd:dateTime

[Term]
id: FBcv:0007547
name: decreased rate of locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'." [GO:0007626, GOC:dph]
synonym: "reduced rate of locomotory behavior" EXACT []
is_a: FBcv:0000414 ! abnormal locomotor behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:31:37Z" xsd:dateTime

[Term]
id: FBcv:0007548
name: decreased rate of adult walking behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'." [GO:0007628, GOC:jid, GOC:pr, ISBN:0198606907]
synonym: "reduced rate of adult walking behavior" EXACT []
is_a: FBcv:0007527 ! abnormal adult walking behavior
is_a: FBcv:0007550 ! decreased rate of adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:31:54Z" xsd:dateTime

[Term]
id: FBcv:0007549
name: decreased rate of larval locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'." [GO:0008345, GOC:ai]
synonym: "reduced rate of larval locomotory behavior" EXACT []
is_a: FBcv:0007528 ! abnormal larval locomotory behavior
is_a: FBcv:0007547 ! decreased rate of locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:32:11Z" xsd:dateTime

[Term]
id: FBcv:0007550
name: decreased rate of adult locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'." [GO:0008344, GOC:ai]
synonym: "reduced rate of adult locomotory behavior" EXACT []
is_a: FBcv:0007529 ! abnormal adult locomotory behavior
is_a: FBcv:0007547 ! decreased rate of locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:32:30Z" xsd:dateTime

[Term]
id: FBcv:0007551
name: decreased rate of mating behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'." [GO:0007617, GOC:ai, GOC:dph]
synonym: "reduced rate of mating behavior" EXACT []
is_a: FBcv:0000721 ! abnormal mating behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:32:56Z" xsd:dateTime

[Term]
id: FBcv:0007552
name: decreased rate of courtship behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'." [GO:0007619, GOC:ai, GOC:dph]
synonym: "reduced rate of courtship behavior" EXACT []
is_a: FBcv:0000399 ! abnormal courtship behavior
is_a: FBcv:0007551 ! decreased rate of mating behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:33:17Z" xsd:dateTime

[Term]
id: FBcv:0007553
name: decreased rate of flight behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'." [GO:0007629, GOC:jid, ISBN:0198606907]
synonym: "reduced rate of flight behavior" EXACT []
is_a: FBcv:0007550 ! decreased rate of adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:33:37Z" xsd:dateTime

[Term]
id: FBcv:0007554
name: decreased rate of jump response
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'." [GO:0007630, GOC:jid, ISBN:0198606907]
synonym: "reduced rate of jump response" EXACT []
is_a: FBcv:0000720 ! abnormal jump response
is_a: FBcv:0007550 ! decreased rate of adult locomotory behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:33:59Z" xsd:dateTime

[Term]
id: FBcv:0007555
name: decreased rate of copulation
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'." [GO:0007620, ISBN:0721662544]
synonym: "reduced rate of copulation" EXACT []
is_a: FBcv:0006000 ! abnormal copulation
is_a: FBcv:0007551 ! decreased rate of mating behavior
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-1373-1705
property_value: http://purl.org/dc/terms/date "2022-08-12T10:34:20Z" xsd:dateTime

[Term]
id: FBcv:0009000
name: single-cell RNA-Seq
namespace: assay_type
def: "A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single cells are subjected to high-throughput sequencing and mapping to a reference genome." [PMID:28821273]
synonym: "scRNA-Seq" EXACT [PMID:32405060]
synonym: "single-cell RNA sequencing assay" EXACT []
xref: EFO:0008913
xref: OBI:0002631
is_a: FBcv:0003068 ! RNA-Seq
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T12:18:07Z" xsd:dateTime

[Term]
id: FBcv:0009001
name: single-nucleus RNA-Seq
namespace: assay_type
def: "A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single nuclei are subjected to high-throughput sequencing and mapping to a reference genome." [PMID:28821273]
synonym: "single-nucleus RNA sequencing assay" EXACT []
synonym: "snRNA-Seq" EXACT [PMID:32405060]
xref: EFO:0009809
is_a: FBcv:0009000 ! single-cell RNA-Seq
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T12:19:45Z" xsd:dateTime

[Term]
id: FBcv:0009002
name: cell clustering analysis
namespace: result_type
def: "A result that groups individual cells into populations sharing a similar transcriptional profile." [PMID:28821273]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T12:21:05Z" xsd:dateTime

[Term]
id: FBcv:0009003
name: transcriptional cell cluster
namespace: result_type
def: "A result that represents a population of cells sharing a similar transcriptional profile." [PMID:28821273]
is_a: FBcv:0003082 ! result type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T12:22:16Z" xsd:dateTime

[Term]
id: FBcv:0009004
name: isolated nuclei
namespace: biosample_type
def: "A biosample containing dissociated cell nuclei isolated from the organism." [FBC:DPG]
is_a: FBcv:0003044 ! biosample type
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T12:23:17Z" xsd:dateTime

[Term]
id: FBcv:0009005
name: single-cell library sequencing
namespace: assay_attribute
def: "A method to prepare and sequence a library of cDNAs obtained from single cells." [FBC:DPG]
is_a: FBcv:0003208 ! assay method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T13:40:26Z" xsd:dateTime

[Term]
id: FBcv:0009006
name: DROP-Seq
namespace: assay_attribute
def: "A method that uses the DROP-Seq platform (Macosko et al., 2015) to prepare and sequence a cDNA library." [PMID:26000488]
is_a: FBcv:0009005 ! single-cell library sequencing
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T13:41:58Z" xsd:dateTime

[Term]
id: FBcv:0009007
name: Smart-seq2
namespace: assay_attribute
def: "A method that uses the Smart-seq2 platform (Picelli et al., 2013) to prepare and sequence a cDNA library." [PMID:24056875]
is_a: FBcv:0009005 ! single-cell library sequencing
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T13:44:02Z" xsd:dateTime

[Term]
id: FBcv:0009008
name: 10x sequencing
namespace: assay_attribute
def: "A method that uses the Chromium platform from 10x Genomics to prepare and sequence a cDNA library." [PMID:29126257]
is_a: FBcv:0009005 ! single-cell library sequencing
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2021-07-26T13:45:06Z" xsd:dateTime

[Term]
id: FBcv:0009009
name: starvation
namespace: biosample_attribute
def: "A sample in which individuals have been deprived of food." [FBC:DPG]
is_a: FBcv:0003146 ! growth condition
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2022-02-03T18:11:36Z" xsd:dateTime

[Term]
id: FBcv:0009010
name: cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells." [EFO:0009091]
xref: EFO:0009091
is_a: FBcv:0009015 ! biosample preparation method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2022-02-16T14:12:02Z" xsd:dateTime

[Term]
id: FBcv:0009011
name: mechanical cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells by applying mechanical forces." [EFO:0009129]
xref: EFO:0009129
is_a: FBcv:0009010 ! cell dissociation
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2022-02-16T14:14:12Z" xsd:dateTime

[Term]
id: FBcv:0009012
name: enzymatic cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells by using enzymes." [EFO:0009128]
xref: EFO:0009128
is_a: FBcv:0009010 ! cell dissociation
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2022-02-16T14:16:03Z" xsd:dateTime

[Term]
id: FBcv:0009013
name: chemical cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells by using non-enzymatic chemicals." [EFO:0011026]
xref: EFO:0011026
is_a: FBcv:0009010 ! cell dissociation
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2022-02-16T14:19:01Z" xsd:dateTime

[Term]
id: FBcv:0009014
name: biosample treatment method
namespace: biosample_attribute
def: "Experimental treatment method that a biosample has been subjected to." [FBC:DPG]
is_a: FBcv:0003164 ! biosample method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2022-02-17T13:55:39Z" xsd:dateTime

[Term]
id: FBcv:0009015
name: biosample preparation method
namespace: biosample_attribute
def: "Method pertaining to the collection or isolation of a biosample." [FBC:DPG]
is_a: FBcv:0003164 ! biosample method
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2022-02-17T14:12:00Z" xsd:dateTime

[Term]
id: FBcv:0009016
name: conditional gene product degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0005042 ! gene product degradation tag
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-02-23T14:00:00Z" xsd:dateTime

[Term]
id: FBcv:0009017
name: cell type-specific gene expression profile
namespace: result_type
def: "A result that provides the expression values for all (or some subset of) genes in a given biological sample containing cells of a single cell type." [FBC:DPG]
is_a: FBcv:0003088 ! gene expression profile
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-02-24T19:07:31Z" xsd:dateTime

[Term]
id: FBcv:0009018
name: cell type-specific RNA-sequencing analysis
namespace: result_type
def: "An analysis that results from the sequencing of RNAs from multiple highly purified samples." [FBC:DPG]
is_a: FBcv:0003108 ! analysis
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-02-24T19:16:13Z" xsd:dateTime

[Term]
id: FBcv:0009019
name: INTACT nuclei isolation
namespace: biosample_attribute
def: "Nuclei of a single cell type have been isolated with the INTACT (Isolation of Nuclei TAgged in a specific Cell Type) strategy (Henry et al., 2012)." [FlyBase:FBrf0219710]
is_a: FBcv:0003170 ! cell isolation
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-02-24T19:27:43Z" xsd:dateTime

[Term]
id: FBcv:0009020
name: TAPIN nuclei isolation
namespace: biosample_attribute
def: "Nuclei of a single cell type have been isolated with the TAPIN (Tandem Affinity Purification of Intact Nuclei) strategy (Davis et al., 2020)." [FlyBase:FBrf0244935]
synonym: "TAPIN-seq" BROAD [FlyBase:FBrf0244935]
is_a: FBcv:0003170 ! cell isolation
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-02-24T19:29:12Z" xsd:dateTime

[Term]
id: FBcv:0009021
name: nuclear RNA isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of RNA from nuclei." [FBC:DPG]
is_a: FBcv:0003176 ! assay material
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-02-24T19:33:34Z" xsd:dateTime

[Term]
id: FBcv:0009022
name: gene product engineering tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify a gene product of interest in a defined manner." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-03-24T18:05:17Z" xsd:dateTime

[Term]
id: FBcv:0009023
name: protease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of a peptide bond." [GO:0008233]
subset: common_tool_use
synonym: "peptidase" EXACT [FBC:GM]
is_a: FBcv:0009022 ! gene product engineering tool
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-03-24T18:18:03Z" xsd:dateTime

[Term]
id: FBcv:0009024
name: protease target site
namespace: experimental_tool_descriptor
def: "A recognition site for a protease, an enzyme that catalyzes hydrolysis of a peptide bond." [FBC:GM]
is_a: FBcv:0005057 ! protein cleavage tag
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-03-24T18:24:12Z" xsd:dateTime

[Term]
id: FBcv:0009025
name: driver-specific gene expression profile
namespace: result_type
def: "A result that provides the expression values for all (or some subset of) genes in a given biological sample obtained using a specific transcriptional driver (or combination of drivers), when that driver is not associated to a clearly identified cell type." [FBC:DPG]
is_a: FBcv:0003088 ! gene expression profile
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-04-21T12:58:46Z" xsd:dateTime

[Term]
id: FBcv:0009026
name: split system combination
namespace: experimental_tool_descriptor
def: "A combination of two or more 'split system components' that together reconstitute a functional experimental tool." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-07-24T11:13:29Z" xsd:dateTime

[Term]
id: FBcv:0009027
name: split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments." [FBC:GM]
is_a: FBcv:0005051 ! split system component
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-07-31T17:10:54Z" xsd:dateTime

[Term]
id: FBcv:0009028
name: conditional split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0009027 ! split driver fragment
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-07-31T17:13:57Z" xsd:dateTime

[Term]
id: FBcv:0009029
name: light-regulated split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0009028 ! conditional split driver fragment
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-07-31T17:16:35Z" xsd:dateTime

[Term]
id: FBcv:0009030
name: small molecule-regulated split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
synonym: "small-molecule regulated split driver fragment" EXACT []
is_a: FBcv:0009028 ! conditional split driver fragment
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6095-8718
property_value: http://purl.org/dc/terms/date "2023-07-31T17:18:43Z" xsd:dateTime

[Term]
id: FBcv:0010000
name: obsolete living stock
comment: Consider - FBsv:0000002.
is_obsolete: true

[Term]
id: FBcv:0010001
name: obsolete molecular extract
comment: Consider - FBsv:0000003.
is_obsolete: true

[Term]
id: FBcv:0010002
name: obsolete preserved specimen
comment: Consider - FBsv:0000005.
is_obsolete: true

[Term]
id: FBcv:0010003
name: obsolete E cytotype stock
is_obsolete: true

[Term]
id: FBcv:0010004
name: obsolete M cytotype stock
is_obsolete: true

[Term]
id: FBcv:0010005
name: obsolete genomic DNA
comment: Consider - FBsv:0000004.
is_obsolete: true

[Term]
id: FBcv:0010006
name: obsolete ethanol-preserved specimen
comment: Consider - FBsv:0000007.
is_obsolete: true

[Term]
id: FBcv:0010007
name: obsolete pinned specimen
is_obsolete: true

[Term]
id: FBcv:0010009
name: obsolete fluorescent balancer
comment: Consider - FBsv:0001010.
is_obsolete: true

[Term]
id: FBcv:0010010
name: obsolete lacZ balancer
comment: Consider - FBsv:0001011.
is_obsolete: true

[Term]
id: FBcv:0010011
name: obsolete laboratory wild-type stock
is_obsolete: true

[Term]
id: FBcv:0010012
name: obsolete collection
comment: Consider - FBsv:0000100.
is_obsolete: true

[Term]
id: FBcv:0010013
name: obsolete stock center collection
comment: Consider - FBsv:0000101.
is_obsolete: true

[Term]
id: FBcv:0010014
name: obsolete laboratory collection
comment: Consider - FBsv:0000102.
is_obsolete: true

[Term]
id: FBcv:0010015
name: obsolete Saxton laboratory
is_obsolete: true

[Term]
id: FBcv:0010016
name: obsolete Garcia-Bellido laboratory
comment: Consider - FBsv:0000109.
is_obsolete: true

[Term]
id: FBcv:0010017
name: obsolete Nusslein-Volhard laboratory
comment: Consider - FBsv:0000108.
is_obsolete: true

[Term]
id: FBcv:0010018
name: obsolete Carpenter laboratory
comment: Consider - FBsv:0000110.
is_obsolete: true

[Term]
id: FBcv:0010019
name: obsolete Artavanis laboratory
synonym: "Harvard Medical School Exelixis Drosophila Collection" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010020
name: obsolete Exelixis Drosophila Stock Collection at Harvard Medical School
comment: Consider - FBsv:0000105.
synonym: "Artavanis-Tsakonas laboratory" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010021
name: obsolete Bloomington Drosophila Stock Center
comment: Consider - FBsv:0000103.
synonym: "BDSC" RELATED []
synonym: "Bloomington" EXACT []
synonym: "BSC" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010022
name: obsolete San Diego Drosophila Species Stock Center
comment: Consider - FBsv:0000106.
synonym: "Drosophila species stock center" RELATED []
synonym: "species stock center" EXACT []
synonym: "Tucson" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010023
name: obsolete Szeged Drosophila Stock Centre
synonym: "Szeged" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010024
name: obsolete Drosophila Genetic Resource Center
comment: Consider - FBsv:0000104.
synonym: "DGRC" RELATED []
synonym: "Kyoto" RELATED []
synonym: "Kyoto stock center" RELATED []
is_obsolete: true

[Typedef]
id: BFO:0000050
name: part of
def: "a core relation that holds between a part and its whole" []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000111 "is part of" xsd:string
property_value: IAO:0000112 "my brain is part of my body (continuant parthood, two material entities)" xsd:string
property_value: IAO:0000112 "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)" xsd:string
property_value: IAO:0000112 "this day is part of this year (occurrent parthood)" xsd:string
property_value: IAO:0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string
property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string
property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string
property_value: IAO:0000118 "part_of" xsd:string
property_value: RO:0001900 RO:0001901
property_value: RO:0040042 BFO:0000002
property_value: RO:0040042 BFO:0000003
property_value: RO:0040042 BFO:0000004
property_value: RO:0040042 BFO:0000017
property_value: RO:0040042 BFO:0000019
property_value: RO:0040042 BFO:0000020
property_value: RO:0040042 BFO:0000031
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf
property_value: seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Part_of" xsd:anyURI
is_transitive: true
is_a: RO:0002131 ! overlaps
inverse_of: BFO:0000051 ! has part

[Typedef]
id: BFO:0000051
name: has part
def: "a core relation that holds between a whole and its part" []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000111 "has part" xsd:string
property_value: IAO:0000112 "my body has part my brain (continuant parthood, two material entities)" xsd:string
property_value: IAO:0000112 "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)" xsd:string
property_value: IAO:0000112 "this year has part this day (occurrent parthood)" xsd:string
property_value: IAO:0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." xsd:string
property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string
property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." xsd:string
property_value: IAO:0000118 "has_part" xsd:string
property_value: RO:0001900 RO:0001901
is_transitive: true
is_a: RO:0002131 ! overlaps

[Typedef]
id: BFO:0000062
name: preceded by
def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
subset: ro-eco
property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string
property_value: IAO:0000111 "preceded by" xsd:string
property_value: IAO:0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string
property_value: IAO:0000118 "is preceded by" xsd:string
property_value: IAO:0000118 "preceded_by" xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent
holds_over_chain: BFO:0000050 BFO:0000062
is_transitive: true
is_a: RO:0002086 ! ends after
inverse_of: BFO:0000063 ! precedes

[Typedef]
id: BFO:0000063
name: precedes
def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
subset: ro-eco
property_value: IAO:0000111 "precedes" xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent
holds_over_chain: BFO:0000050 BFO:0000063
is_transitive: true
is_a: RO:0002222 ! temporally related to

[Typedef]
id: FBcv:0008000
name: has_age
is_functional: true

[Typedef]
id: FBdv:00018001
name: substage of
namespace: relationship
def: "A relation between a developmental stage and another, larger developmental stage during which it happens." [FBC:DPG]
comment: Creating this relation as a temporary fix, pending adding the axiom occurrent_part_of subproperty of happens_during to RO.
is_transitive: true
is_a: BFO:0000050 ! part of

[Typedef]
id: RO:0000052
name: characteristic of
def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." []
comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
property_value: IAO:0000111 "inheres in" xsd:string
property_value: IAO:0000112 "this fragility is a characteristic of this vase" xsd:string
property_value: IAO:0000112 "this red color is a characteristic of this apple" xsd:string
property_value: IAO:0000118 "inheres_in" xsd:string
property_value: RO:0001900 RO:0001901
is_functional: true
is_a: RO:0002314 ! characteristic of part of
inverse_of: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000053
name: has characteristic
def: "Inverse of characteristic_of" []
property_value: IAO:0000111 "bearer of" xsd:string
property_value: IAO:0000112 "this apple is bearer of this red color" xsd:string
property_value: IAO:0000112 "this vase is bearer of this fragility" xsd:string
property_value: IAO:0000116 "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist." xsd:string
property_value: IAO:0000118 "bearer_of" xsd:string
property_value: IAO:0000118 "is bearer of" xsd:string
property_value: RO:0001900 RO:0001901
range: BFO:0000020 ! specifically dependent continuant
is_inverse_functional: true

[Typedef]
id: RO:0000056
name: participates in
def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" []
property_value: IAO:0000111 "participates in" xsd:string
property_value: IAO:0000112 "this blood clot participates in this blood coagulation" xsd:string
property_value: IAO:0000112 "this input material (or this output material) participates in this process" xsd:string
property_value: IAO:0000112 "this investigator participates in this investigation" xsd:string
property_value: IAO:0000118 "participates_in" xsd:string
domain: BFO:0000002 ! continuant
range: BFO:0000003 ! occurrent
inverse_of: RO:0000057 ! has participant

[Typedef]
id: RO:0000057
name: has participant
def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" []
property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string
property_value: IAO:0000111 "has participant" xsd:string
property_value: IAO:0000112 "this blood coagulation has participant this blood clot" xsd:string
property_value: IAO:0000112 "this investigation has participant this investigator" xsd:string
property_value: IAO:0000112 "this process has participant this input material (or this output material)" xsd:string
property_value: IAO:0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string
property_value: IAO:0000118 "has_participant" xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000002 ! continuant
holds_over_chain: BFO:0000051 RO:0000057

[Typedef]
id: RO:0000079
name: function of
def: "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
property_value: IAO:0000112 "this catalysis function is a function of this enzyme" xsd:string
property_value: IAO:0000116 "A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists." xsd:string
property_value: IAO:0000118 "function_of" xsd:string
property_value: IAO:0000118 "is function of" xsd:string
domain: BFO:0000034 ! function
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000085 ! has function

[Typedef]
id: RO:0000080
name: quality of
def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
property_value: IAO:0000112 "this red color is a quality of this apple" xsd:string
property_value: IAO:0000116 "A quality inheres in its bearer at all times for which the quality exists." xsd:string
property_value: IAO:0000118 "is quality of" xsd:string
property_value: IAO:0000118 "quality_of" xsd:string
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000086 ! has quality

[Typedef]
id: RO:0000081
name: role of
def: "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
property_value: IAO:0000112 "this investigator role is a role of this person" xsd:string
property_value: IAO:0000116 "A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists." xsd:string
property_value: IAO:0000118 "is role of" xsd:string
property_value: IAO:0000118 "role_of" xsd:string
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000087 ! has role

[Typedef]
id: RO:0000085
name: has function
def: "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence" []
property_value: IAO:0000112 "this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)" xsd:string
property_value: IAO:0000116 "A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists." xsd:string
property_value: IAO:0000118 "has_function" xsd:string
domain: BFO:0000004 ! independent continuant
range: BFO:0000034 ! function
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000086
name: has quality
def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" []
property_value: IAO:0000112 "this apple has quality this red color" xsd:string
property_value: IAO:0000116 "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist." xsd:string
property_value: IAO:0000118 "has_quality" xsd:string
range: BFO:0000019 ! quality
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000087
name: has role
def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" []
property_value: IAO:0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)" xsd:string
property_value: IAO:0000116 "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists." xsd:string
property_value: IAO:0000118 "has_role" xsd:string
domain: BFO:0000004 ! independent continuant
range: BFO:0000023 ! role
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000091
name: has disposition
def: "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence" []
domain: BFO:0000004 ! independent continuant
range: BFO:0000016 ! disposition
is_a: RO:0000053 ! has characteristic
inverse_of: RO:0000092 ! disposition of

[Typedef]
id: RO:0000092
name: disposition of
def: "inverse of has disposition" []
comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
subset: RO:0002259
is_a: RO:0000052 ! characteristic of

[Typedef]
id: RO:0002013
name: has regulatory component activity
def: "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." []
is_a: RO:0002017 ! has component activity
is_a: RO:0002334 ! regulated by
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:30:46Z

[Typedef]
id: RO:0002014
name: has negative regulatory component activity
def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." []
comment: By convention GO molecular functions are classified by their effector function.  Internal regulatory functions are treated as components.  For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.
is_a: RO:0002013 ! has regulatory component activity
is_a: RO:0002335 ! negatively regulated by
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:01Z

[Typedef]
id: RO:0002015
name: has positive regulatory component activity
def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." []
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components.  So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
is_a: RO:0002013 ! has regulatory component activity
is_a: RO:0002336 ! positively regulated by
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:17Z

[Typedef]
id: RO:0002017
name: has component activity
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
is_a: RO:0002018 ! has component process
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:44:33Z

[Typedef]
id: RO:0002018
name: has component process
def: "w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." []
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_a: RO:0002180 ! has component
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:49:21Z

[Typedef]
id: RO:0002022
name: directly regulated by
comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="https://orcid.org/0000-0002-7073-9172"}
is_a: RO:0002334 ! regulated by
inverse_of: RO:0002578 ! directly regulates
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:24Z

[Typedef]
id: RO:0002023
name: directly negatively regulated by
def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: RO:0002630 ! directly negatively regulates
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:38Z

[Typedef]
id: RO:0002024
name: directly positively regulated by
def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: RO:0002629 ! directly positively regulates
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:47Z

[Typedef]
id: RO:0002025
name: has effector activity
def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." [https://orcid.org/0000-0002-7073-9172]
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
is_functional: true
is_a: RO:0002017 ! has component activity
created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-22T14:14:36Z

[Typedef]
id: RO:0002081
name: before or simultaneous with
comment: Primitive instance level timing relation between events
subset: ro-eco
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
property_value: IAO:0000118 "<=" xsd:string
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002083
name: before
comment: t1 before t2 iff:=  t1 before_or_simulataneous_with t2  and not (t1 simultaeous_with t2)
subset: ro-eco
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
is_transitive: true
is_a: RO:0002081 ! before or simultaneous with

[Typedef]
id: RO:0002086
name: ends after
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)
subset: ro-eco
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
is_transitive: true
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002087
name: immediately preceded by
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
property_value: IAO:0000118 "starts_at_end_of" xsd:string
is_a: BFO:0000062 ! preceded by
inverse_of: RO:0002090 ! immediately precedes

[Typedef]
id: RO:0002090
name: immediately precedes
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)
subset: ro-eco
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: IAO:0000118 "ends_at_start_of" xsd:string
property_value: IAO:0000118 "meets" xsd:string
property_value: RO:0002575 BFO:0000063
is_a: BFO:0000063 ! precedes

[Typedef]
id: RO:0002131
name: overlaps
def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
subset: ro-eco
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: BFO:0000050 BFO:0000050
holds_over_chain: BFO:0000051 BFO:0000050 {RO:0002582="true"}
holds_over_chain: BFO:0000051 RO:0002131
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
transitive_over: BFO:0000050 ! part of
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" []

[Typedef]
id: RO:0002180
name: has component
def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." []
subset: ro-eco
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." xsd:string
property_value: IAO:0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit." xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:Componency
is_a: BFO:0000051 ! has part

[Typedef]
id: RO:0002202
name: develops from
def: "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" []
comment: This is the transitive form of the develops from relation
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: IAO:0000117 https://orcid.org/0000-0003-1980-3228
domain: BFO:0000004 ! independent continuant
range: BFO:0000004 ! independent continuant
is_transitive: true
is_a: RO:0002254 ! has developmental contribution from
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002203 ! develops into

[Typedef]
id: RO:0002203
name: develops into
def: "inverse of develops from" []
subset: RO:0002259
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: IAO:0000117 https://orcid.org/0000-0003-1980-3228
is_transitive: true
is_a: RO:0002286 ! developmentally succeeded by
is_a: RO:0002387 ! has potential to develop into
is_a: RO:0002388 ! has potential to directly develop into

[Typedef]
id: RO:0002211
name: regulates
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0001-7476-6306
property_value: IAO:0000117 https://orcid.org/0000-0002-3837-8864
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "GO" xsd:string
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000232 "Regulation precludes parthood; the regulatory process may not be within the regulated process." xsd:string
property_value: IAO:0000589 "regulates (processual)" xsd:string
property_value: IAO:0000600 "false" xsd:boolean
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
holds_over_chain: RO:0002578 RO:0002578
is_transitive: true
is_a: RO:0002411 ! causally upstream of
inverse_of: RO:0002334 ! regulated by
transitive_over: RO:0002025 ! has effector activity

[Typedef]
id: RO:0002212
name: negatively regulates
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "negatively regulates (process to process)" xsd:string
property_value: RO:0004050 RO:0002211
is_a: RO:0002211 ! regulates
is_a: RO:0002305 ! causally upstream of, negative effect
inverse_of: RO:0002335 ! negatively regulated by

[Typedef]
id: RO:0002213
name: positively regulates
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "positively regulates (process to process)" xsd:string
property_value: RO:0004049 RO:0002211
holds_over_chain: RO:0002212 RO:0002212
is_transitive: true
is_a: RO:0002211 ! regulates
is_a: RO:0002304 ! causally upstream of, positive effect
inverse_of: RO:0002336 ! positively regulated by

[Typedef]
id: RO:0002215
name: capable of
def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " []
subset: ro-eco
property_value: IAO:0000112 "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)" xsd:string
property_value: IAO:0000112 "osteoclast SubClassOf 'capable of' some 'bone resorption'" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function realized in" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20123131
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/21208450
property_value: IAO:0000232 "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." xsd:string
domain: BFO:0000004 ! independent continuant
range: BFO:0000015 ! process
is_a: RO:0002216 ! capable of part of

[Typedef]
id: RO:0002216
name: capable of part of
def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
holds_over_chain: RO:0002215 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002328 ! functionally related to
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002222
name: temporally related to
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.
subset: ro-eco
property_value: http://purl.org/dc/terms/source "https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1" xsd:anyURI
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 https://en.wikipedia.org/wiki/Allen%27s_interval_algebra
property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent

[Typedef]
id: RO:0002233
name: has input
def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
subset: ro-eco
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "consumes" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Has_input" xsd:anyURI
domain: BFO:0000015 ! process
is_a: RO:0000057 ! has participant
inverse_of: RO:0002352 ! input of

[Typedef]
id: RO:0002254
name: has developmental contribution from
def: "x has developmental contribution from y iff x has some part z such that z develops from y" []
property_value: IAO:0000112 "Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: UBERON:0001062
range: UBERON:0001062
holds_over_chain: BFO:0000051 RO:0002202
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002255 ! developmentally contributes to

[Typedef]
id: RO:0002255
name: developmentally contributes to
def: "inverse of has developmental contribution from" []
subset: RO:0002259
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
holds_over_chain: RO:0002203 BFO:0000050
is_a: RO:0002286 ! developmentally succeeded by
is_a: RO:0002385 ! has potential to developmentally contribute to

[Typedef]
id: RO:0002258
name: developmentally preceded by
def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" []
comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000116 "false" xsd:boolean
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "In general you should not use this relation to make assertions - use one of the more specific relations below this one" xsd:string
domain: BFO:0000002 ! continuant
range: BFO:0000002 ! continuant
is_a: RO:0002324 ! developmentally related to
inverse_of: RO:0002286 ! developmentally succeeded by

[Typedef]
id: RO:0002263
name: acts upstream of
def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: IAO:0000112 "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." xsd:string
property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of
holds_over_chain: RO:0002327 RO:0002411
is_a: RO:0002264 ! acts upstream of or within

[Typedef]
id: RO:0002264
name: acts upstream of or within
def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
synonym: "affects" RELATED []
property_value: IAO:0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within" xsd:anyURI
holds_over_chain: RO:0002327 RO:0002418
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002286
name: developmentally succeeded by
def: "Inverse of developmentally preceded by" []
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002384 ! has developmental potential involving

[Typedef]
id: RO:0002304
name: causally upstream of, positive effect
def: "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." []
comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004049 RO:0002411
property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_positive_effect
is_a: RO:0002411 ! causally upstream of
is_a: RO:0004047 ! causally upstream of or within, positive effect

[Typedef]
id: RO:0002305
name: causally upstream of, negative effect
def: "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004050 RO:0002411
property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_negative_effect
is_a: RO:0002411 ! causally upstream of
is_a: RO:0004046 ! causally upstream of or within, negative effect

[Typedef]
id: RO:0002314
name: characteristic of part of
def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." []
property_value: IAO:0000116 "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
holds_over_chain: RO:0000052 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002323
name: mereotopologically related to
def: "A mereological relationship or a topological relationship" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" xsd:string
property_value: RO:0001900 RO:0001901

[Typedef]
id: RO:0002324
name: developmentally related to
def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development" xsd:string

[Typedef]
id: RO:0002327
name: enables
def: "c enables p iff c is capable of p and c acts to execute p." []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: IAO:0000112 "a particular instances of akt-2 enables some instance of protein kinase activity" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "catalyzes" xsd:string
property_value: IAO:0000118 "executes" xsd:string
property_value: IAO:0000118 "has" xsd:string
property_value: IAO:0000118 "is catalyzing" xsd:string
property_value: IAO:0000118 "is executing" xsd:string
property_value: IAO:0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Enables" xsd:anyURI
is_a: RO:0002215 ! capable of
inverse_of: RO:0002333 ! enabled by
transitive_over: BFO:0000051 ! has part
transitive_over: RO:0002017 ! has component activity

[Typedef]
id: RO:0002328
name: functionally related to
def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" xsd:string

[Typedef]
id: RO:0002329
name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
holds_over_chain: BFO:0000050 RO:0002215 {RO:0002581="true"}
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002331
name: involved in
def: "c involved_in p if and only if c enables some process p', and p' is part of p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "actively involved in" xsd:string
property_value: IAO:0000118 "enables part of" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Involved_in" xsd:anyURI
holds_over_chain: RO:0002327 BFO:0000050
is_a: RO:0000056 ! participates in
is_a: RO:0002431 ! involved in or involved in regulation of
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002333
name: enabled by
def: "inverse of enables" []
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: seeAlso "https://wiki.geneontology.org/Enabled_by" xsd:anyURI
is_a: RO:0000057 ! has participant
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002334
name: regulated by
def: "inverse of regulates" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000589 "regulated by (processual)" xsd:string
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_transitive: true
is_a: RO:0002427 ! causally downstream of or within

[Typedef]
id: RO:0002335
name: negatively regulated by
def: "inverse of negatively regulates" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002334 ! regulated by

[Typedef]
id: RO:0002336
name: positively regulated by
def: "inverse of positively regulates" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002334 ! regulated by

[Typedef]
id: RO:0002350
name: member of
def: "is member of is a mereological relation between a item and a collection." []
property_value: IAO:0000112 "An organism that is a member of a population of organisms" xsd:string
property_value: IAO:0000118 "is member of" xsd:string
property_value: IAO:0000118 "member part of" xsd:string
property_value: IAO:0000119 "SIO" xsd:string
property_value: RO:0001900 RO:0001901
is_a: BFO:0000050 ! part of
inverse_of: RO:0002351 ! has member

[Typedef]
id: RO:0002351
name: has member
def: "has member is a mereological relation between a collection and an item." []
property_value: IAO:0000119 "SIO" xsd:string
property_value: RO:0001900 RO:0001901
is_a: BFO:0000051 ! has part

[Typedef]
id: RO:0002352
name: input of
def: "inverse of has input" []
subset: ro-eco
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0000056 ! participates in
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002384
name: has developmental potential involving
def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: UBERON:0001062
range: UBERON:0001062
is_a: RO:0002324 ! developmentally related to

[Typedef]
id: RO:0002385
name: has potential to developmentally contribute to
def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002384 ! has developmental potential involving

[Typedef]
id: RO:0002387
name: has potential to develop into
def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002384 ! has developmental potential involving

[Typedef]
id: RO:0002388
name: has potential to directly develop into
def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002387 ! has potential to develop into

[Typedef]
id: RO:0002404
name: causally downstream of
def: "inverse of upstream of" []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: BFO:0000062 ! preceded by
is_a: RO:0002427 ! causally downstream of or within
inverse_of: RO:0002411 ! causally upstream of

[Typedef]
id: RO:0002405
name: immediately causally downstream of
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002087 ! immediately preceded by
is_a: RO:0002404 ! causally downstream of
inverse_of: RO:0002412 ! immediately causally upstream of

[Typedef]
id: RO:0002407
name: indirectly positively regulates
def: "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly activates" xsd:string
property_value: RO:0002579 RO:0002213
property_value: seeAlso "https://wiki.geneontology.org/Indirectly_positively_regulates" xsd:anyURI
holds_over_chain: RO:0002409 RO:0002409
holds_over_chain: RO:0002629 RO:0002407
holds_over_chain: RO:0002629 RO:0002629
is_transitive: true
is_a: RO:0002213 ! positively regulates
is_a: RO:0012012 ! indirectly regulates
transitive_over: RO:0002629 ! directly positively regulates

[Typedef]
id: RO:0002409
name: indirectly negatively regulates
def: "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly inhibits" xsd:string
property_value: RO:0002579 RO:0002212
property_value: seeAlso "https://wiki.geneontology.org/Indirectly_negatively_regulates" xsd:anyURI
holds_over_chain: RO:0002630 RO:0002409
holds_over_chain: RO:0002630 RO:0002630
is_transitive: true
is_a: RO:0002212 ! negatively regulates
is_a: RO:0012012 ! indirectly regulates
transitive_over: RO:0002630 ! directly negatively regulates

[Typedef]
id: RO:0002410
name: causally related to
def: "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." [https://en.wikipedia.org/wiki/Causality]
property_value: IAO:0000116 "This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.\n\nTo define causal relations in an activity-flow type network, we make use of 3 primitives:\n\n * Temporal: how do the intervals of the two occurrents relate? \n * Is the causal relation regulatory?\n * Is the influence positive or negative?\n\nThe first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.\n\nFor the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.\n\nFor the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.\n\nEach of these 3 primitives can be composed to yield a cross-product of different relation types." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string

[Typedef]
id: RO:0002411
name: causally upstream of
def: "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_transitive: true
is_a: BFO:0000063 ! precedes
is_a: RO:0002418 ! causally upstream of or within

[Typedef]
id: RO:0002412
name: immediately causally upstream of
def: "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: RO:0002575 RO:0002411
is_a: RO:0002090 ! immediately precedes
is_a: RO:0002411 ! causally upstream of

[Typedef]
id: RO:0002418
name: causally upstream of or within
def: "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." []
synonym: "affects" RELATED []
property_value: IAO:0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "influences (processual)" xsd:string
is_transitive: true
is_a: RO:0002501 ! causal relation between processes
inverse_of: RO:0002427 ! causally downstream of or within

[Typedef]
id: RO:0002427
name: causally downstream of or within
def: "inverse of causally upstream of or within" []
subset: RO:0002259
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
is_transitive: true
is_a: RO:0002501 ! causal relation between processes

[Typedef]
id: RO:0002428
name: involved in regulation of
def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
holds_over_chain: RO:0002327 RO:0002211
holds_over_chain: RO:0002331 RO:0002211
is_a: RO:0002263 ! acts upstream of
is_a: RO:0002431 ! involved in or involved in regulation of

[Typedef]
id: RO:0002429
name: involved in positive regulation of
def: "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: RO:0004049 RO:0002428
holds_over_chain: RO:0002327 RO:0002213
holds_over_chain: RO:0002331 RO:0002213
is_a: RO:0002428 ! involved in regulation of

[Typedef]
id: RO:0002430
name: involved in negative regulation of
def: "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: RO:0004050 RO:0002428
holds_over_chain: RO:0002327 RO:0002212
holds_over_chain: RO:0002331 RO:0002212
is_a: RO:0002428 ! involved in regulation of

[Typedef]
id: RO:0002431
name: involved in or involved in regulation of
def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" []
property_value: IAO:0000116 "OWL does not allow defining object properties via a Union" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "involved in or reguates" xsd:string
is_a: RO:0002264 ! acts upstream of or within
is_a: RO:0002328 ! functionally related to
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002434
name: interacts with
def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." []
subset: ro-eco
synonym: "in pairwise interaction with" EXACT []
property_value: closeMatch "http://purl.obolibrary.org/obo/MI_0914" xsd:anyURI
property_value: IAO:0000116 "Considering relabeling as 'pairwise interacts with'" xsd:anyURI
property_value: IAO:0000116 "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." xsd:string
property_value: seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/" xsd:anyURI
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_symmetric: true

[Typedef]
id: RO:0002436
name: molecularly interacts with
def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." []
property_value: closeMatch "http://purl.obolibrary.org/obo/MI_0915" xsd:anyURI
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "binds" xsd:string
property_value: IAO:0000118 "molecularly binds with" xsd:string
property_value: seeAlso ECO:0000353
is_symmetric: true
is_a: RO:0002434 ! interacts with

[Typedef]
id: RO:0002448
name: directly regulates activity of
def: "The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.\n\nA and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B." []
synonym: "molecularly controls" EXACT []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002436 ! molecularly interacts with
is_a: RO:0011002 ! regulates activity of

[Typedef]
id: RO:0002449
name: directly negatively regulates activity of
def: "The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." []
synonym: "molecularly decreases activity of" EXACT []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
property_value: IAO:0000118 "directly inhibits" xsd:string
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002448 ! directly regulates activity of

[Typedef]
id: RO:0002450
name: directly positively regulates activity of
def: "The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." []
synonym: "molecularly increases activity of" EXACT []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
property_value: IAO:0000118 "directly activates" xsd:string
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002448 ! directly regulates activity of

[Typedef]
id: RO:0002500
name: causal agent in process
def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" []
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
is_a: RO:0002595 ! causal relation between material entity and a process
inverse_of: RO:0002608 ! process has causal agent

[Typedef]
id: RO:0002501
name: causal relation between processes
def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string
domain: BFO:0000003 ! occurrent
range: BFO:0000003 ! occurrent
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002502
name: depends on
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: seeAlso BFO:0000169

[Typedef]
id: RO:0002503
name: towards
def: "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" []
property_value: IAO:0000116 "This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
is_a: RO:0002502 ! depends on

[Typedef]
id: RO:0002506
name: causal relation between entities
property_value: IAO:0000116 "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string
domain: BFO:0000002 ! continuant
range: BFO:0000002 ! continuant
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002559
name: causally influenced by
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "causally influenced by (entity-centric)" xsd:string
is_a: RO:0002506 ! causal relation between entities
inverse_of: RO:0002566 ! causally influences

[Typedef]
id: RO:0002566
name: causally influences
def: "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "causally influences (entity-centric)" xsd:string
domain: BFO:0000002 ! continuant
range: BFO:0000002 ! continuant
is_a: RO:0002506 ! causal relation between entities

[Typedef]
id: RO:0002573
name: has modifier
def: "A relation that holds between an attribute or a qualifier and another attribute." []
subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: IAO:0000232 "This relation is intended to be used in combination with PATO, to be able to refine PATO quality classes using modifiers such as 'abnormal' and 'normal'. It has yet to be formally aligned into an ontological framework; it's not clear what the ontological status of the \"modifiers\" are." xsd:string
domain: BFO:0000020 ! specifically dependent continuant
range: BFO:0000020 ! specifically dependent continuant

[Typedef]
id: RO:0002578
name: directly regulates
def: "p directly regulates q iff p is immediately causally upstream of q and p regulates q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly regulates (processual)" xsd:string
property_value: RO:0002575 RO:0002211
is_a: RO:0002211 ! regulates
is_a: RO:0002412 ! immediately causally upstream of

[Typedef]
id: RO:0002584
name: has part structure that is capable of
def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" []
property_value: IAO:0000112 "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
holds_over_chain: BFO:0000051 RO:0002215
is_a: RO:0002328 ! functionally related to
is_a: RO:0002595 ! causal relation between material entity and a process

[Typedef]
id: RO:0002595
name: causal relation between material entity and a process
def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." []
property_value: IAO:0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
domain: BFO:0000040 ! material entity
range: BFO:0000015 ! process
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002596
name: capable of regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." []
property_value: IAO:0000112 "pyrethroid -> growth" xsd:string
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
holds_over_chain: RO:0002215 RO:0002211
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002597
name: capable of negatively regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." []
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
holds_over_chain: RO:0002215 RO:0002212
is_a: RO:0002596 ! capable of regulating

[Typedef]
id: RO:0002598
name: capable of positively regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." []
property_value: IAO:0000112 "renin -> arteriolar smooth muscle contraction" xsd:string
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
holds_over_chain: RO:0002215 RO:0002213
is_a: RO:0002596 ! capable of regulating

[Typedef]
id: RO:0002608
name: process has causal agent
def: "Inverse of 'causal agent in process'" []
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002629
name: directly positively regulates
def: "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly positively regulates (process to process)" xsd:string
property_value: RO:0004049 RO:0002578
property_value: seeAlso "https://wiki.geneontology.org/Directly_positively_regulates" xsd:anyURI
is_a: RO:0002213 ! positively regulates
is_a: RO:0002578 ! directly regulates

[Typedef]
id: RO:0002630
name: directly negatively regulates
def: "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly negatively regulates (process to process)" xsd:string
property_value: RO:0004050 RO:0002578
property_value: seeAlso "https://wiki.geneontology.org/Directly_negatively_regulates" xsd:anyURI
is_a: RO:0002212 ! negatively regulates
is_a: RO:0002578 ! directly regulates

[Typedef]
id: RO:0004031
name: enables subfunction
def: "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." []
holds_over_chain: RO:0002327 BFO:0000051
is_a: RO:0002328 ! functionally related to
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-25T23:20:13Z

[Typedef]
id: RO:0004032
name: acts upstream of or within, positive effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002264
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004047
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:49:30Z

[Typedef]
id: RO:0004033
name: acts upstream of or within, negative effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002264
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004046
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:49:51Z

[Typedef]
id: RO:0004034
name: acts upstream of, positive effect
def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002263
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0002304
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004032 ! acts upstream of or within, positive effect
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:53:14Z

[Typedef]
id: RO:0004035
name: acts upstream of, negative effect
def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002263
property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0002305
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004033 ! acts upstream of or within, negative effect
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-01-26T23:53:22Z

[Typedef]
id: RO:0004046
name: causally upstream of or within, negative effect
property_value: RO:0004050 RO:0002418
property_value: seeAlso "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect" xsd:anyURI
is_a: RO:0002418 ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:05Z

[Typedef]
id: RO:0004047
name: causally upstream of or within, positive effect
property_value: RO:0004049 RO:0002418
property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect
is_a: RO:0002418 ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:19Z

[Typedef]
id: RO:0011002
name: regulates activity of
def: "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." []
property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431
domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences

[Typedef]
id: RO:0012011
name: indirectly causally upstream of
def: "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." []
is_a: RO:0002411 ! causally upstream of
created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:07:17Z

[Typedef]
id: RO:0012012
name: indirectly regulates
def: "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." []
is_a: RO:0002211 ! regulates
is_a: RO:0012011 ! indirectly causally upstream of
created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:08:01Z

[Typedef]
id: RO:0017001
name: device utilizes material
def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." []
synonym: "utilizes" BROAD []
property_value: IAO:0000112 "A diagnostic testing device utilizes a specimen." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0001-9625-1899
property_value: IAO:0000117 https://orcid.org/0000-0003-2620-0345
property_value: IAO:0000232 "A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input." xsd:string
property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-relations/issues/497" xsd:string
holds_over_chain: RO:0002215 RO:0002233
creation_date: 2021-11-08T12:00:00Z

[Typedef]
id: RO:0019000
name: regulates characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." []
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599
domain: BFO:0000015 ! process
holds_over_chain: RO:0002211 RO:0019000
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0019001
name: positively regulates characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." []
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599
holds_over_chain: RO:0002213 RO:0019001
is_a: RO:0019000 ! regulates characteristic

[Typedef]
id: RO:0019002
name: negatively regulates characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." []
property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599
holds_over_chain: RO:0002212 RO:0019001
holds_over_chain: RO:0002213 RO:0019002
is_a: RO:0019000 ! regulates characteristic

[Typedef]
id: conditionality
name: conditionality