METADATA
last updated: 2025-12-14 RT after BA fixed inconsistencies
file_name: SDS - TCEP.md
file_date: 2020-12-29
title: Safety Data Sheet - TCEP
category: guides
subcategory: sds
tags: 
source_file_type: pdf
xfile_type: NA
gfile_url: NA
xfile_github_download_url: NA
pdf_gdrive_url: https://drive.google.com/file/d/189DnIKWpB47VrvaCwIgxdtrQpn8uPSHA
pdf_github_url: https://github.com/FocusOnFoundationsNonprofit/floodlamp-archive/blob/main/guides/sds/SDS%20-%20TCEP.pdf
conversion_input_file_type: pdf
conversion: ai (claude sonnet 3.5)
license: public domain
tokens: 3450
words: 2061
notes: 
summary_short: The Safety Data Sheet for TCEP (tris(2-carboxyethyl)phosphine hydrochloride, CAS 51805-45-9) provides hazard classification, first aid, storage, PPE, spill response, and disposal guidance for laboratory and synthesis use. It identifies the substance as strongly corrosive (causes severe skin burns and serious eye damage) and recommends strict protective equipment and locked, dry storage at 2–8 °C. The sheet also lists transport requirements as UN 3261, Class 8, Packing Group II (corrosive solid, acidic, organic, n.o.s.).


CONTENT

***INTERNAL TITLE:*** Sigma-Aldrich - Safety Data Sheet

**Version 6.4**
**Revision Date 12/29/2020**
**Print Date 07/31/2021**

## SECTION 1: Identification of the substance/mixture and of the company/undertaking
### 1.1 Product identifiers
- Product name: Tris(2-carboxyethyl)phosphine hydrochloride
- Product Number: C4706
- Brand: Aldrich
- CAS-No.: 51805-45-9

### 1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Synthesis of substances

### 1.3 Details of the supplier of the safety data sheet
- Company: Sigma-Aldrich Inc.
- Address: 3050 SPRUCE ST, ST. LOUIS MO 63103, UNITED STATES
- Telephone: +1 314 771-5765
- Fax: +1 800 325-5052

### 1.4 Emergency telephone
Emergency Phone #: 800-424-9300 CHEMTREC (USA) +1-703-527-3887 CHEMTREC (International) 24 Hours/day; 7 Days/week

## SECTION 2: Hazards identification
### 2.1 Classification of the substance or mixture
**GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)**
- Skin corrosion (Category 1B), H314
- Serious eye damage (Category 1), H318

For the full text of the H-Statements mentioned in this Section, see Section 16.

### 2.2 GHS Label elements, including precautionary statements
**Pictogram**

[Pictogram placeholder]

**Signal word**: Danger

**Hazard statement(s)**:
- H314 Causes severe skin burns and eye damage.

**Precautionary statement(s)**:
- P260 Do not breathe dusts or mists.
- P264 Wash skin thoroughly after handling.
- P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
- P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
- P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
- P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.
- P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.
- P363 Wash contaminated clothing before reuse.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant.

### 2.3 Hazards not otherwise classified (HNOC) or not covered by GHS
None

## SECTION 3: Composition/information on ingredients
### 3.1 Substances
- Synonyms: TCEP
- Formula: C₉H₁₅O₆P · HCl
- Molecular weight: 286.65 g/mol
- CAS-No.: 51805-45-9

| Component | Classification | Concentration |
|-----------|----------------|---------------|
| Tris(2-carboxyethyl)phosphine hydrochloride | Skin Corr. 1B; Eye Dam. 1; H314, H318 | <= 100 % |
||

For the full text of the H-Statements mentioned in this Section, see Section 16.

## SECTION 4: First aid measures
### 4.1 Description of first-aid measures
**General advice**:
First aider needs to protect himself. Show this material safety data sheet to the doctor in attendance.

**If inhaled**:
After inhalation: fresh air. Call in physician.

**In case of skin contact**:
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

**In case of eye contact**:
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

**If swallowed**:
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.

### 4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

### 4.3 Indication of any immediate medical attention and special treatment needed
No data available

## SECTION 5: Firefighting measures
### 5.1 Extinguishing media
**Suitable extinguishing media**:
Water, Foam, Carbon dioxide (CO2), Dry powder

**Unsuitable extinguishing media**:
For this substance/mixture no limitations of extinguishing agents are given.

### 5.2 Special hazards arising from the substance or mixture
- Carbon oxides
- Oxides of phosphorus
- Hydrogen chloride gas
- Combustible
- Development of hazardous combustion gases or vapours possible in the event of fire.

### 5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

### 5.4 Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

## SECTION 6: Accidental release measures
### 6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.

### 6.2 Environmental precautions
Do not let product enter drains.

### 6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

### 6.4 Reference to other sections
For disposal see section 13.

## SECTION 7: Handling and storage
### 7.1 Precautions for safe handling
**Advice on safe handling**:
Protect from moisture.

**Hygiene measures**:
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

### 7.2 Conditions for safe storage, including any incompatibilities
**Storage conditions**:
Tightly closed. Dry.

**Storage stability**:
Recommended storage temperature 2 - 8 °C

**Storage class (TRGS 510)**: 8A: Combustible, corrosive hazardous materials

### 7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

## SECTION 8: Exposure controls/personal protection
### 8.1 Control parameters
**Ingredients with workplace control parameters**:
Contains no substances with occupational exposure limit values.

### 8.2 Exposure controls
**Appropriate engineering controls**:
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

**Personal protective equipment**:
**Eye/face protection**:
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

**Skin protection**:
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

**Full contact**:
- Material: Nitrile rubber
- Minimum layer thickness: 0.11 mm
- Break through time: 480 min
- Material tested: KCL 741 Dermatril® L

**Splash contact**:
- Material: Nitrile rubber
- Minimum layer thickness: 0.11 mm
- Break through time: 480 min
- Material tested: KCL 741 Dermatril® L

**Body Protection**:
Protective clothing

**Respiratory protection**:
Required when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

**Control of environmental exposure**:
Do not let product enter drains.

## SECTION 9: Physical and chemical properties
### 9.1 Information on basic physical and chemical properties
a) Appearance
   - Form: powder
   - Color: white

b) Odor: No data available
c) Odor Threshold: No data available
d) pH: No data available
e) Melting point/freezing point: Melting point/range: 175 - 177 °C (347 - 351 °F)
f) Initial boiling point and boiling range: No data available
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: No data available
l) Vapor density: No data available
m) Relative density: 1.041 g/cm³ at 25 °C (77 °F)
n) Water solubility: soluble
o) Partition coefficient: n-octanol/water: No data available
p) Autoignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

### 9.2 Other safety information
No data available

## SECTION 10: Stability and reactivity
### 10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

### 10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature).

### 10.3 Possibility of hazardous reactions
Violent reactions possible with: Strong oxidizing agents

### 10.4 Conditions to avoid
No information available

### 10.5 Incompatible materials
No data available

### 10.6 Hazardous decomposition products
In the event of fire: see section 5

## SECTION 11: Toxicological information
### 11.1 Information on toxicological effects
**Acute toxicity**:
- LD50 Oral - Rat - 3,500 mg/kg
- LD50 Oral - Rat - 3,500 mg/kg
  Remarks: (External MSDS)
- Inhalation: No data available
- LD50 Dermal - Rat - > 3,000 mg/kg
- LD50 Dermal - Rat - 3,000 mg/kg
  Remarks: (External MSDS)

**Skin corrosion/irritation**:
No data available

**Serious eye damage/eye irritation**:
No data available

**Respiratory or skin sensitization**:
No data available

**Germ cell mutagenicity**:
No data available

**Carcinogenicity**:
- IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
- NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
- OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA's list of regulated carcinogens.

**Reproductive toxicity**:
No data available

**Specific target organ toxicity - single exposure**:
No data available

**Specific target organ toxicity - repeated exposure**:
No data available

**Aspiration hazard**:
No data available

### 11.2 Additional Information
Not available

Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

## SECTION 12: Ecological information
### 12.1 Toxicity
No data available

### 12.2 Persistence and degradability
No data available

### 12.3 Bioaccumulative potential
No data available

### 12.4 Mobility in soil
No data available

### 12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

### 12.6 Other adverse effects
No data available

## SECTION 13: Disposal considerations
### 13.1 Waste treatment methods
**Product**:
Waste material must be disposed of in accordance with the national and local regulations. No mixing with other waste. Handle uncleaned containers like the product. See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

## SECTION 14: Transport information
**DOT (US)**
- UN number: 3261
- Class: 8
- Packing group: II
- Proper shipping name: Corrosive solid, acidic, organic, n.o.s. (Tris(2-carboxyethyl)phosphine hydrochloride)
- Reportable Quantity (RQ):
- Poison Inhalation Hazard: No

**IMDG**
- UN number: 3261
- Class: 8
- Packing group: II
- EMS-No: F-A, S-B
- Proper shipping name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (Tris(2-carboxyethyl)phosphine hydrochloride)

**IATA**
- UN number: 3261
- Class: 8
- Packing group: II
- Proper shipping name: Corrosive solid, acidic, organic, n.o.s. (Tris(2-carboxyethyl)phosphine hydrochloride)

## SECTION 15: Regulatory information
**SARA 302 Components**:
This material does not contain any components with a section 302 EHS TPQ.

**SARA 313 Components**:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

**Massachusetts Right To Know Components**:
No components are subject to the Massachusetts Right to Know Act.

## SECTION 16: Other information
**Further information**:
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
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Version: 6.4 Revision Date: 12/29/2020 Print Date: 07/31/2021