METADATA
last updated: 2026-03-06 by BA
file_name: XPrize FloodLAMP Submission - Slides.md
file_date: 2020-09-08
title: FloodLAMP XPRIZE Qualifying Submission - Presentation Slides
category: various
subcategory: xprize
tags:
source_file_type: gslide
xfile_type: pptx
gfile_url: https://docs.google.com/presentation/d/1-Dd9oNqmi2FmppZ0Xpw7G6Hh5zIz2bsI044IPjb2x5U/
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pdf_gdrive_url: https://drive.google.com/file/d/1cJaAi1EGXlDuoViG8LRER1EnwJgVYmcL/
pdf_github_url: https://github.com/FocusOnFoundationsNonprofit/floodlamp-archive-wip/blob/main/various/xprize/XPrize%20FloodLAMP%20Submission%20-%20Slides.pdf
conversion_input_file_type: pptx
conversion: msmid
license: CC BY 4.0 - https://creativecommons.org/licenses/by/4.0/
tokens: 1045
words: 641
notes: Image-heavy presentation; slide titles and text content preserved, visual elements described in italics.
summary_short: FloodLAMP's 12-slide XPRIZE Qualifying Submission presentation covers the company's mission, the Rabe Cepko RT-LAMP assay technology, unique positioning for scaling community screening at low cost, pooling strategy for infectious detection, user-centered at-home sample collection workflow via custom app, field inactivation station design, and lab facilities at MBC Biolabs.


CONTENT

## Slide 1: FloodLAMP Biotechnologies
a Public Benefit Corporation
_FloodLAMP company logo_

floodlamp.bio

## Slide 2: Our Mission
To deploy mass screening to stop the spread of infectious disease.

## Slide 3: Overview of Technology Involved
Sample Collection
- Coordinated by Custom App
- Self pooling by household

Assay Chemistry - Rabe Cepko Protocol from Harvard Medical School:
- Chemical Inactivation using TCEP/EDTA
- Nucleic Acid Purification Protocol using ultra cheap Silica
- Isothermal LAMP amplification with colorimetric readout

## Slide 4: Rabe Cepko RT-LAMP Assay
_Photos showing the three-step Rabe Cepko RT-LAMP assay process_

Inactivation:
- Chemical (TCEP) + Heat
- Deployable outside a lab

Purification:
- Bulk Silica
- Allows larger volumes
- Ultra cheap

Amplification:
- Colorimetric LAMP
- Isothermal
- Instrument Free

## Slide 5: Unique Positioning
_Chart comparing testing approaches by upfront lab setup cost vs throughput, chart data transformed to table below_

| Throughput     | Upfront Lab Setup Cost | Entity/Method                                      |
|----------------|------------------------|----------------------------------------------------|
| 10-200/day     | $5-10K                 | Community Direct-LAMP                              |
| 1-3K/day       | $5-10K                 | FloodLAMP (non-pooled)                             |
| 10K/day to 50K/day | $5-10K                 | FloodLAMP (non-pooled) — Scaling at our facility while also enabling many other labs to scale through openly sharing protocols and procedures. |
| 1-3K to 10K/day| $1-50M                 | Color, Curative, LetsGetChecked                    |
| 1-3K to 10K/day| $1-50M                 | Medium Thruput Academic Labs: IGI, UCSF, Stanford  |
| 50K/day        | $100-250M              | Summer.bio                                         |
| 50K/day        | $100-250M              | Amazon Broad                                       |
||

## Slide 6: Scaling in Multiple Ways
_Diagrams illustrating three scaling strategies_

1. Increase capacity at our facility with automation
2. Enable distributed network of labs through open protocols
3. IVD EUA to widely distribute full assay kits

## Slide 7: Pooling for Infectious Detection
Threshold for "Capable to Infect Others" ~ 1e6/ml

Pooling uses assay sensitivity to scale up coverage - and detect unknown infectious people in interacting populations.

_Diagram illustrating virus kinetics within an individual over ~25 days post-infection, plotting virus concentration on a logarithmic scale through incubation, transmissible, and post-infectious phases, with curves for live virus and viral RNA copies. There's a red bar that appears between approximately days 3–5 (during early incubation/pre-peak), and a yellow bar spans from roughly day 15 to beyond day 25 (post-transmission period)._
Low sensitivity test false-negative only when taken in red/yellow times
But...Only the red area matters clinically & is a very short window of time!

Yellow time period is after transmission period has ended

## Slide 8: Benefitting Public Health
_Illustrations of public health screening scenarios_

Our open protocol and scaling-friendly set up costs mean low overhead (training, cost, equipment) to better screen the populations that need it most.

## Slide 9: User-centered Screening
_Screenshots of the FloodLAMP custom app interface_

- At-home collection
- Pooling by household or pod
- Custom software for recording samples and tracking results
- Prompts for repeat screens

## Slide 10: Sample Collection Workflow
_Illustrations showing the 6-step sample collection workflow_

1. Register
   - Visit app and register
   - Your info added
   - Your organization (if applicable)
2. Get
   - Receive your kit in the mail
   - Review instructions
3. Learn
   - Watch videos on collection techniques and process
   - Prepare other participants if you're a sponsor
4. Collect
   - Identify who you're collecting for in app
   - Collect individual samples + record in app
   - Pool samples + record in app
5. Drop off
   - Drop samples in secure drop box and record in app OR
   - Drop with staff member who records in system
6. View status
   - See state of your sample (in transit, processing, result, etc)
   - See updates for next collection
   - Sharing options for adoption spread

## Slide 11: Field Inactivation Station
_Photo showing the field inactivation station setup_

## Slide 12: FloodLAMP Facilities at MBC Biolabs
_Photos of FloodLAMP laboratory facilities at MBC Biolabs_